MH - Aberrant Motor Behavior in Dementia UI - D000096762 MN - F1.145.126.50 MS - Aberrant motor behaviors leading to inappropriate or purposeless activities in people with dementia. Aberrant motor behaviors in people with dementia include aggression, agitation, refusal to care and wandering. HN - 2024 BX - Aberrant Motor Behaviors in Dementia BX - Aggression in Dementia BX - Agitation in Dementia BX - Care Refusal in Dementia BX - Care Rejection in Dementia BX - Dementia Aggression BX - Dementia Agitation BX - Dementia Wandering BX - Disturbance in Motor Function in Dementia BX - Disturbances in Motor Function in Dementia BX - Rejection of Care in Dementia BX - Wandering in Dementia MH - Academia UI - D000097788 MN - I2.79 MS - The environment concerned with the pursuit of research, education, and scholarship. HN - 2024 MH - Acute Care Surgery UI - D000096725 MN - H2.403.810.104 MS - Surgical specialty generally encompassing emergency general surgery, surgical critical care and trauma care. Acute care surgery is a component of general surgery related to care of patients with acute, life-threatening or potentially life-threatening surgical conditions. HN - 2024 BX - Emergency General Surgery BX - Surgical Critical Care BX - Surgical Trauma Care BX - Trauma Surgery MH - Acylphosphatase UI - D000097024 MN - D8.811.277.40.19 MS - An enzyme that catalyzes the conversion of an acylphosphate and water to a carboxylate and phosphate. HN - 2024 (1973) BX - Acetic Phosphatase BX - Acylphosphate Phosphohydrolase BX - CAP Phosphatase BX - Carbamyl Phosphate Phosphatase MH - Aflatoxin Poisoning UI - D000096702 MN - C25.723.680.131 MS - Poisoning by AFLATOXINS most often associated with NAUSEA, abdominal pain, hepatotoxicity, immunosuppression, HEPATOCELLULAR CARCINOMA and sometimes death. HN - 2024 BX - Aflatoxicosis BX - Aflatoxin Toxicity MH - AIRE Protein UI - D000096927 MN - D12.776.930.123 MS - A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY. HN - 2024 (1997) BX - APECED Protein BX - Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein BX - Autoimmune Regulator Protein MH - Altmetrics UI - D000097783 MN - L1.462.500.682.99.325.250 MN - L1.462.750.183.291.250 MS - Non-traditional journal impact measures that include tracking of downloads; mentions in SOCIAL MEDIA, NEWS reports, BLOGS, and online ENCYCLOPEDIAS; links in bookmarking services and online reference managers; and crowd-based reviews. HN - 2024 BX - Almetric Analysis BX - Almetric Attention BX - Almetric Attention Score BX - Almetric Attention Scores BX - Almetric Study BX - Almetrics Analyses BX - Almetrics Analysis BX - Almetrics Attention BX - Almetrics Attention Score BX - Almetrics Attention Scores BX - Almetrics Scores BX - Altmetric Data BX - Altmetric Evaluation BX - Altmetric Indicators BX - Altmetric Measures BX - Altmetric Measurment BX - Altmetric Score BX - Altmetric Scores BX - Altmetrics Score MH - Amphidinolides UI - D000097442 MN - D2.540.505.113 MN - D2.540.576.500.250 MN - D4.345.674.500.250 MS - Complex macrolides produced by marine dinoflagellates such as AMPHIDINIUM. Many amphidinolides and related iriomoteolides are cytotoxic which disturb MICROTUBULE activities. HN - 2024 BX - Amphidinolide BX - Iriomoteolide BX - Iriomoteolides MH - Amphidinols UI - D000095722 MN - D2.355.291.933.63 MN - D2.540.576.625.63 MN - D4.345.241.654.63 MN - D4.345.674.625.63 MN - D23.946.580.80 MS - Long linear polyketides with polyol groups and polyolefins and core motifs of two tetrahydropyran rings produced by marine dinoflagellates such as AMPHIDINIUM. Many amphidinols are hemolytic toxins with antifungal and other cytotoxic activities. HN - 2024 BX - Amphidinol MH - Angiogenesis UI - D000096482 MN - G9.330.20 MS - Formation of new blood vessels, which is controlled by chemical signals in the body, such as VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF). This process involves the migration, growth, and differentiation of ENDOTHELIAL CELLS, which line the inside wall of blood vessels. HN - 2024 FX - Neovascularization, Pathologic FX - Neovascularization, Physiologic MH - Angucyclines and Angucyclinones UI - D000095602 MN - D2.455.426.559.847.149.401 MN - D2.540.576.375 MN - D2.806.250.45 MN - D4.345.674.313 MN - D4.615.149.401 MS - Polycyclic aromatic polyketides with tetracyclic angular benz(a)anthracene skeletons. Angucyclines and related angucyclinones are produced by Actinomycetes, e.g., STREPTOMYCES, using type II polyketide synthase involving condensation of acetyl CoA and 9 malonyl-CoA. HN - 2024 BX - Angucycline Aglycons BX - Angucycline and Angucyclinone Derivatives BX - Angucycline Antibiotics BX - Angucyclines BX - Angucyclinone Antibiotics BX - Angucyclinones FX - Anthraquinones MH - Anthrones UI - D000095322 MN - D2.455.426.559.847.117.380 MN - D4.615.125.380 MS - Anthracenes with one ketone group, typically 9,10-dihydroanthracene carrying an oxo group at C-9. HN - 2024; use ANTHRACENES 2004-2023 BX - Anthranones MH - ATP-Binding Cassette Sub-Family B Member 4 UI - D000097202 MN - D9.400.430.890.20.400.767 MN - D12.776.157.530.100.75.750 MN - D12.776.157.530.450.74.500.500.250.719 MN - D12.776.395.550.20.400.767 MN - D12.776.543.550.192.400.767 MN - D12.776.543.585.100.200.719 MN - D12.776.543.585.450.74.500.500.250.719 MS - An ATP-binding cassette, sub-family B protein that functions in translocating PHOSPHATIDYLCHOLINES from the inner to the outer leaflet of the canalicular membrane of the HEPATOCYTES. HN - 2024 (1999) BX - MDR2 Protein BX - Multidrug Resistance Protein 2 BX - P-Glycoprotein 2 BX - Pgp2 protein BX - Phosphatidylcholine Translocator ABCB4 MH - ATPase Inhibitory Protein UI - D000097795 MN - D12.776.575.140 MS - CA(2+) MG(2+)-ATPASE inhibitor found in membranes of mammalian ERYTHROCYTES. HN - 2024 (1978) BX - Epsilon Subunit, F1-ATPase BX - F(0)F(1)-Inhibitor Protein BX - F1-ATPase Epsilon Subunit BX - Inhibitor Factor 1, ATPase BX - Na-K ATPase Inhibitor MH - Avatar UI - D000095902 MN - L1.224.160.875.250 MN - L1.224.900.910.750 MN - L1.296.555.250 MS - A computer representation of users in a computer-generated world. Avatar technology is used in various applications such as in education, exercise, gaming and training. HN - 2024 BX - Humanoid Avatar FX - Caricature MH - Bacterial Lysates UI - D000095983 MN - D20.215.57 MS - Extracts derived from BACTERIA. HN - 2024 BX - Bacterial Extract BX - Bacterial Extracts MH - Benzenesulfonamides UI - D000096926 MN - D2.65.884.60 MN - D2.455.426.559.389.85 MN - D2.886.590.700.90 MS - A group of compounds that contain sulfonamide group S-linked to a benzene ring. Many benzenesulfonamide derivatives are pharmaceuticals (e.g., BOSENTAN; SULFAPYRIDINE; and SULFADIAZINE; CELECOXIB) as their sulfonamide moiety target various enzymes (e.g., CARBONIC ANHYDRASES; ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; and CYCLOOXYNENASE 2). HN - 2024(1983) BX - Benzenesulfonamide BX - Benzenesulfonamide Derivatives BX - Benzenesulfonamide Monosodium Salt BX - Benzenesulphonamides BX - Benzosulfonamides MH - Benzoisochromanequinones UI - D000095622 MN - D2.540.576.438 MN - D2.806.250.90 MN - D3.383.663.283.240.95 MN - D3.633.100.150.240.95 MN - D4.345.674.375 MS - Polycyclic aromatic polyketides with tricyclic benzoisochrome quinone skeletons. Benzoisochromanequinones are produced by Actinobacteria, e.g., STREPTOMYCES COELICOLOR, using type II minimal polyketide synthase involving condensation of 8 malonyl-CoA in actinorhodin pathway. HN - 2024 BX - Benzoisochromanequinone Antibiotics MH - beta Lactam Antibiotics UI - D000097902 MN - D27.505.954.122.85.386 MS - Bactericidal agents that contain a beta-lactam ring in their chemical structure. They inhibit bacterial cell wall synthesis by binding to PENICILLIN-BINDING PROTEINS, preventing the synthesis of peptidoglycan in bacterial cell walls. HN - 2024 BX - beta Lactam Antibacterial Agents BX - beta Lactam Antibacterials BX - beta-Lactam Antibiotics MH - Bioactive Peptides, Dietary UI - D000097482 MN - D12.644.90 MN - D12.776.256.258 MN - G7.203.300.428.540 MN - J2.500.428.540 MS - Peptides that are derived from dietary protein and which can modulate physiological functions. HN - 2024 BX - Dietary Bioactive Peptides BX - Food-Derived Bioactive Peptides MH - Biocuration UI - D000096104 MN - L1.313.124.125 MS - Translation and integration of biological information into databases or other resources that allow integration of the scientific literature as well as large datasets, enabling both humans and computers to access the data. HN - 2024 FX - Medical Informatics Computing MH - Bioenhancers UI - D000097082 MN - D26.650.64.750 MN - D27.720.744.64.750 MS - Agents that are used to increase the BIOAVAILABILITY and bioefficacy of a drug, without any therapeutic activity of its own. HN - 2024 BX - Bioavailability Enhancer BX - Bioenhancer BX - Bioenhancer Agent BX - Biopotentiators MH - Bitis UI - D000097187 MN - B1.50.50.286.875.875.875.125 MN - B1.50.150.900.833.672.125.937.875.125 MN - B1.50.150.900.833.672.562.875.875.125 MS - A genus of Viperinae subfamily. Bitis snakes are found in Africa and Arabia. Bitis includes African puff adder (Bitis arietans) and horned adder (Bitis caudalis). HN - 2024(1994) BX - Bitis gabonica BX - Gaboon Adder BX - Gaboon Viper MH - Blue Light UI - D000095743 MN - G1.358.500.505.650.220 MN - G1.590.540.100 MN - G1.750.250.650.220 MN - G1.750.770.578.220 MS - That portion of the electromagnetic spectrum with wavelengths between 450 to 495 nm. Exposure to blue light at night can suppress the secretion of melatonin, disrupt sleep, and cause shifts in CIRCADIAN RHYTHM. HN - 2024 MH - BNT162b5 UI - D000096106 MN - D12.776.828.868.228.500.875 MN - D20.215.894.815.750 MN - D20.215.894.865.450.500.875 MN - D20.215.894.899.85.750 MN - D23.50.865.450.500.875 MS - A combined mRNA vaccine, developed by Pfizer and BioNTech against SARS-CoV-2 with a mixture of the original strain of SARS-CoV-2 and BA.4 and BA.5 lineages of the omicron variant of SARS-CoV-2. HN - 2024 BX - COVID-19 Vaccine Pfizer-BioNTech, Bivalent BX - Pfizer-BioNTech COVID-19 Vaccine, Bivalent MH - Bothrops asper UI - D000097143 MN - B1.50.50.286.875.875.240.375.750 MN - B1.50.150.900.833.672.125.937.240.375.750 MN - B1.50.150.900.833.672.562.875.240.375.750 MS - A species of venomous pit viper of the BOTHROPS genus. Bothrops asper are found in Mexico, Central America and northern South America including Trinidad. B. asper is commonly called terciopelo. HN - 2024 BX - Terciopelo MH - Bothrops atrox UI - D000097142 MN - B1.50.50.286.875.875.240.375.500 MN - B1.50.150.900.833.672.125.937.240.375.500 MN - B1.50.150.900.833.672.562.875.240.375.500 MS - A species of venomous pit viper of the BOTHROPS genus. Bothrops atrox are found in the tropical lowlands of northern South America east of the Andes and Trinidad where it is called mapepire balsain. B. atrox is more commonly called common lancehead and fer-de-lance. BATROXOBIN is usually isolated from B. atrox venom. HN - 2024(1994) BX - Barba Amarilla BX - Coluber atrox BX - Common Lancehead BX - Fer-de-Lance BX - Trimeresurus atrox MH - Bothrops jararaca UI - D000097145 MN - B1.50.50.286.875.875.240.375.875 MN - B1.50.150.900.833.672.125.937.240.375.875 MN - B1.50.150.900.833.672.562.875.240.375.875 MS - A species of venomous snakes of the BOTHROPS genus. Bothrops jararaca is found in South America and commonly called jararaca. HN - 2024 BX - Bothropoides jararaca BX - Jararaca Snake MH - Bothrops jararaca Venom UI - D000097146 MN - D20.888.850.960.200.158 MN - D23.946.833.850.960.200.158 MS - Snake venoms isolated from BOTHROPS JARARACA. B. jararaca venoms contain a hemorrhagic metalloproteinase toxn jararhagin which binds to VON WILLEBRAND FACTOR. HN - 2024 BX - Bothrops jararaca Venoms BX - HF2 -Proteinase BX - Jaracetin BX - Jararaca Venom BX - Jararhagin MH - Brain Drain UI - D000096283 MN - I1.240.600.525.500.500 MN - N1.224.625.525.500.500 MN - N6.850.505.400.700.525.500.500 MS - A phenomenon of concern for migrant-sending countries, particularly for small countries where high-skilled emigration rates are highest. include those with sought after technical, professional and other skills. Economic theory suggests a number of possible benefits, in addition to costs, from skilled emigration. (From https://openknowledge.worldbank.org/handle/10986/3878?show=full). HN - Emigration and Immigration (1987-2024) BX - Human Capital Flight FX - Foreign Professional Personnel MH - Brainwashing UI - D000096965 MN - L1.143.762.500 MS - A broad class of intense and often coercive tactics intended to produce profound changes in attitudes, beliefs, and emotions. Targets of such tactics have typically been prisoners of war and members of religious cults. (From https://dictionary.apa.org/brainwashing) HN - 2024 BX - Forced Indoctrination BX - Mind Control FX - Coercion MH - Bulk Drugs UI - D000095485 MN - D26.25 MS - Any substance that is represented for use in a drug and that, when used in the manufacturing, processing, or packaging of a drug, becomes an active ingredient or a finished dosage form of the drug. Does not include intermediates used in the synthesis of such substances. HN - 2024 BX - Active Pharmaceutical Ingredients BX - Bulk Drug Substances MH - Bungarus multicinctus UI - D000097144 MN - B1.50.50.286.875.750.225.500 MN - B1.50.150.900.833.672.125.875.225.500 MN - B1.50.150.900.833.672.562.750.225.500 MS - A venomous elapid snake species of BUNGARUS genus found in the marshlands of Southeast Asia and central and southern China. Its common name many-banded krait refers to the numerous white bands across its body. B. multicinctus venom is BUNGAEOTIXINS. HN - 2024 BX - Bungarus multicinctus multicinctus BX - Bungarus multicinctus wanghaotingi BX - Bungarus wanghaotingi BX - Chinese Krait BX - Many-Banded Krait MH - Calponins UI - D000096985 MN - D5.750.78.730.266 MN - D12.776.157.125.123 MN - D12.776.210.500.187 MN - D12.776.220.525.268 MS - A family of actin binding proteins mostly in smooth muscle. Calponins include most abundant alpha-calponin (h1 or basic); beta-calponin; neutral calponin (h2 calponin); acidic calponin, SM22, and transgelin. Calponin family members have N-terminal single Calponin Homology (CH) domain and multiple C-terminus 23-amino acids long calponin-like repeats called CLICK-23. Calponins participate in modulation of smooth muscle contraction by binding to ACTINS (F- and G-Actins), CALMODULIN and TROPOMYSIN. HN - 2024 BX - Calponin BX - Calponin Family Proteins MH - Cannabinoid Hyperemesis Syndrome UI - D000096704 MN - C25.775.635.500 MN - F3.900.635.500 MS - Recurrent vomiting accompanied by nausea, abdominal pain and sometimes compulsive hot bathing behavior in chronic CANNABIS abuse. HN - 2024 BX - Cannabis Hyperemesis Syndrome MH - Carbohydrate Sulfotransferases UI - D000097811 MN - D8.811.913.817.400.650 MS - Transmembrane enzymes of the Golgi network that recognize glycans attached to LIPIDS and PROTEINS passing through the secretory pathway. HN - 2024 (1999) BX - Carbohydrate Sulfotransferase 1 BX - Carbohydrate Sulfotransferase 2 BX - Carbohydrate Sulfotransferase 3 BX - Carbohydrate Sulfotransferase 4 BX - Carbohydrate Sulfotransferase 5 BX - Carbohydrate Sulfotransferase 6 BX - Carbohydrate Sulfotransferase 7 BX - Chondroitin 6-Sulfotransferase BX - Corneal N-Acetylglucosamine 6-O-Sulfotransferase BX - GlcNAc-6-O-Sulfotransferase BX - Intestinal N-Acetylglucosamine 6-O-Sulfotransferase BX - Keratan Sulfate Gal-6 Sulfotransferase BX - Keratan Sulfate Gal-6-Sulfotransferase BX - Keratan Sulfotransferase BX - Keratan Sulfurtransferase MH - Cardio-Oncology UI - D000097562 MN - H2.403.429.163.650 MN - H2.403.429.515.125 MS - The study, diagnosis, and treatment of CARDIOTOXICITY in patients who undergo treatment for cancer. HN - 2024 BX - Cardiooncology BX - Cardiovascular Oncology MH - Cavernous Sinus Syndromes UI - D000096826 MN - C10.228.140.232 MS - Disease processes of the CAVERNOUS SINUS. HN - 2024 BX - Cavernous Sinus Syndrome MH - CD68 Molecule UI - D000097382 MN - D9.400.430.890.550.125 MN - D12.776.395.550.550.125 MN - D12.776.543.550.527.125 MN - D12.776.543.750.705.940.718.500 MN - D12.776.543.750.710.450.750.718.500 MN - D23.50.301.264.35.567 MN - D23.50.301.264.900.23 MN - D23.101.100.110.567 MN - D23.101.100.900.23 MS - A single-pass type 1 transmembrane glycoprotein that localizes to LYSOSOMES; ENDOSOMES; and cell surface CELL MEMBRANES. It is a member of the lysosomal associated membrane glycoprotein family and the scavenger receptor family. The highly glycosylated extracellular domain binds to tissue- and organ-specific LECTINS or SELECTINS. HN - 2024 (1991) BX - CD68 Antigen BX - LAMP4 Protein BX - Lysosomal-Associated Membrane Protein 4 BX - Macrosialin BX - SCARD1 Protein BX - Scavenger Receptor Class D, Member 1 MH - CD83 Antigen UI - D000097802 MN - D9.400.430.890.15 MN - D12.776.124.486.485.256 MN - D12.776.124.790.651.256 MN - D12.776.377.715.548.256 MN - D12.776.395.550.15 MN - D12.776.543.550.68 MN - D23.50.301.264.35.783 MN - D23.101.100.110.783 MS - A glycoprotein member of the immunoglobulin superfamily that is primarily expressed on the surface of DENDRITIC CELLS. It is believed to play a role in ANTIGEN PRESENTATION and CELL-TO-CELL INTERACTION following LYMPHOCYTE ACTIVATION. HN - 2024 (1995) BX - Antigen, CD83 BX - Cell Surface Protein HB15 MH - CEACAM1 Protein UI - D000096723 MN - D9.400.430.890.200.107 MN - D12.776.395.550.200.107 MN - D12.776.543.550.200.126 MN - D23.50.301.350.107 MS - A cell adhesion protein that is cross-reactive with CARCINOEMBRYONIC ANTIGEN, involved in regulating VEGFR2 signaling pathway and insulin functions. Also, play a role as coinhibitory receptor in immune response and as an activator during angiogenesis. HN - 2024 BX - Biliary Glycoprotein A BX - Biliary Glycoprotein I BX - Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 BX - CD66a Antigen BX - CEA-Related Cell Adhesion Molecule 1 BX - Cell-CAM 105 BX - CellCAM 105 BX - Nonspecific Cross-Reacting Antigen 160 MH - Cefiderocol UI - D000097602 MN - D2.65.589.99.249.175 MN - D2.886.665.74.175 MN - D3.633.100.300.249.175 MN - D27.505.519.914.500.410.750.500 MN - D27.720.832.500.410.750.500 MS - A siderophore cephalosporin with enhanced activity against GRAM-NEGATIVE AEROBIC BACTERIA. HN - 2024 (2016) BX - Cefiderocol Sulfate Tosylate BX - Fetroja MH - Cefozopran UI - D000097586 MN - D2.65.589.99.249.179 MN - D2.886.665.74.179 MN - D3.383.129.617.264 MN - D3.633.100.300.249.179 MS - A fourth-generation cephalosporin antibacterial agent with a broad spectrum of activity against Gram-positive and Gram-negative bacteria. Cefozopran has a 1-methyltetrazolethiol (MTT) moiety at C-3 of its cephalosporin core. HN - 2024 (1991) BX - Cefozopran (CZOP) BX - Cefozopran HCL BX - Cefozopran Hydrochloride MH - Cefpirome UI - D000097572 MN - D2.65.589.99.249.181 MN - D2.886.665.74.181 MN - D3.633.100.300.249.181 MS - A fourth-generation cephalosporin antibacterial agent. Appears to be more active in vitro against Staphylococci, some Enterococci, some ENTEROBACTERIACEAE, and PSEUDOMONAS AERUGINOSA.Cefpirome has a pyridinium group attached to C-3 position of its cephalosporin core. HN - 2024 (1983) BX - Cefpirome Sulfate MH - Cefpodoxime UI - D000097623 MN - D2.65.589.99.249.176 MN - D2.886.665.74.176 MN - D3.633.100.300.249.176 MS - A third-generation cephalosporin antibiotic. Cefpodoxime contains a methoxy group at C-3 of its cephalosporin core. HN - 2024 BX - 5-Thia-1-Azabicyclo(4.2.0)oct-2-ene-2-Carboxylic Acid, 7-(((2-Amino-4-Thiazolyl)(Methoxyimino)Acetyl)Amino)-3-(Methoxymethyl)-8-oxo-, Monosodium Salt, (6R-(6alpha,7beta(Z)))- BX - Cefpodoxime Sodium BX - Cefpodoxime Sodium Salt MH - Cefpodoxime Proxetil UI - D000097627 MN - D2.65.589.99.249.176.500 MN - D2.886.665.74.176.500 MN - D3.633.100.300.249.176.500 MS - A prodrug of its active metabolite CEFPODOXIME. HN - 2024 (1987) BX - 1-(Isopropoxycarbonyloxy)ethyl-7-(2-(2-Amino-4-thiazolyl)-2-(Methoxyimino)Acetamido)-3-Methoxymethyl-8-oxo-5-thia-1-Azabicyclo(4,2,0)-oct-2-ene-2-Carboxylate BX - Cephalosporin 807 BX - Orelox BX - Otreon BX - U-76252 MH - Cefprozil UI - D000097670 MN - D2.65.589.99.249.183 MN - D2.886.665.74.183 MN - D3.633.100.300.249.183 MS - A second-generation cephalosporin antibacterial agent. Cefprozil has a phenyl ring at the C-3 position of its cephalosporin core. HN - 2024 (1987) BX - Cefprozil Monohydrate BX - Cefprozil Sulfate MH - Ceftaroline UI - D000097583 MN - D2.65.589.99.249.186 MN - D2.886.665.74.186 MN - D3.633.100.300.249.186 MS - A fifth-generation cephalosporin antibacterial agent that is used to treat skin infections caused by bacteria in adults and newborns. Ceftaroline has a 1,3-thiazolidine ring attached to the C-7 position of its cephalosporin core. HN - 2024 (2004) BX - Ceftaroline Fosamil BX - Zinforo MH - Centrosomal Associated Proteins UI - D000097402 MN - D12.776.220.148 MS - Proteins that are localized in the CENTROSOME. They help with processes such as MITOSIS and CELL MOTILITY. HN - 2024 BX - Centrosomal Proteins BX - Centrosome Proteins MH - Cerastes UI - D000097189 MN - B1.50.50.286.875.875.875.250 MN - B1.50.150.900.833.672.125.937.875.250 MN - B1.50.150.900.833.672.562.875.875.250 MS - A genus of Viperinae found mostly in Africa, Arabia and India with characteristic horny scale over each eye. Cerastes genus includes Saharan sand viper (Cerastes vipera) and horned desert viper (Cerastes cerastes). A desert sidewinder Crotalus cerastes also has horny scale over its eyes but is a species in sister subfamily Crotalinae and found in Southwest American desert. HN - 2024(1994) MH - Ceriodaphnia dubia UI - D000096622 MN - B1.50.500.131.365.150.100 MS - A freshwater water flea in genus Ceriodaphnia, family Daphniidae, suborder Cladocera. It has postabdominal claw with central pecten, absent rostrum and cervical sinus. It is often used as an indicator organism in toxicological bioassays of FRESHWATERS. HN - 2024 BX - Ceriodaphnia richardi MH - Channa punctatus UI - D000095982 MN - B1.50.150.900.493.105 MS - A species of fish in the snakehead family Channidae, known as the spotted snakehead. HN - 2024 BX - Blotched Snakehead BX - Channa punctata BX - Mud Murrel BX - Spotted Snakehead MH - Chelidonium majus UI - D000097563 MN - B1.875.800.575.912.250.836.500.249.500 MS - A plant species of the family PAPAVERACEAE. The common name greater celandine is similar to lesser celandine (Ficaria verna), and celandine poppy (Stylophorum diphyllum). It has been used in folk medicine and its latex contains biologically active compounds including BENZOPHENANTHRIDINES alkaloids (e.g., Chelerythrine). HN - 2024 BX - Chelidonium majus subsp. asiaticum BX - Chelidonium majus subsp. majus BX - Greater Celandine MH - Chemokine Receptor D6 UI - D000097628 MN - D12.776.543.750.695.160.150.50 MN - D12.776.543.750.705.852.125.150.50 MS - A broad-specificity receptor for inflammatory CC CHEMOKINE. HN - 2024 BX - Atypical Chemokine Receptor 2 BX - Chemokine Binding Protein 2 BX - Chemokine Receptor CCR-9 BX - D6 Chemokine Receptor MH - Chronic Cough UI - D000096822 MN - C8.618.248.500 MN - C23.888.852.293.500 MS - Cough lasting for greater than 8 weeks in adults potentially impacting HEALTH-RELATED QUALITY OF LIFE. Chronic cough generally is associated with eosinophilic airway inflammation (e.g., asthma (COUGH-VARIANT ASTHMA) and non-asthmatic BRONCHITIS, upper airway disorders, GERD and cough hypersensitivity syndrome). HN - 2024 BX - Nagging Cough BX - Persistent Cough MH - Cognitive Reflection UI - D000095486 MN - F2.463.188.318 MS - Deliberate and careful consideration of previous actions, events, experiences, or decisions and the thinking that accompanied these activities. (https://eric.ed.gov/?qt=reflection&ts=on&td=on&ti=Reflection). HN - 2024 BX - Reflection Process BX - Reflection, Cognitive BX - Reflective Practice BX - Reflective Thinking MH - Cohesins UI - D000097722 MN - D12.776.167.163 MN - D12.776.660.235.350 MN - D12.776.664.235.350 MS - Protein complex constituents that bind chromosomes from late G1 until the metaphase - anaphase transition. The cohesin complex regulates sister chromatid cohesion, HOMOLOGOUS RECOMBINATION and DNA looping. HN - 2024 (1999) BX - Cohesin BX - Cohesin Protein Complex MH - Cold Urticaria UI - D000096703 MN - C17.800.862.945.766 MN - C20.543.480.904.766 MS - Various skin flares developing after exposure to cold temperature. While most are characterized by a limited episodic cutaneous condition characterized by URTICARIAL WHEALS, such as in allergic urticaria, other types are more severe and generalized and rarely familial, e.g., cryopyrin-associated periodic syndromes. HN - 2024 MH - Collagen Type XVII UI - D000097805 MN - D12.776.860.300.250.400.544 MN - D23.50.422.93 MS - A 220 kDa non-fibrillar collagen and basement membrane component. It is involved in healing wounds of the EPITHELIUM, CORNEAL. HN - 2024 (1984) BX - 180 kDa Bullous Pemphigoid Autoantigen BX - BP180 Antigen BX - BP180 Autoantigen BX - Bullous Pemphigoid Autoantigen, BP180 BX - Collagen Alpha-1(XVII) Chain BX - Collagen XVII BX - Collagen, Type XVII, Alpha 1 Chain BX - Type XVII Collagen MH - Comic Book UI - D000095493 MN - V2.700.225 MS - Narrative works that employ sequential art, and often prose, to tell a story. (https://id.loc.gov/authorities/genreForms) HN - 2024 MH - Comic Books as Topic UI - D000096103 MN - J1.897.280.500.117.250 MN - L1.462.500.682.192.289.250 MS - Works about narrative works that employ sequential art, and often prose, to tell a story. (LCSH, 2023) HN - 2024 MH - Community of Practice UI - D000097163 MN - F2.784.629.529.663.500 MN - L1.143.910.125 MS - Core concept of learning and knowledge management, a repository where knowledge is developed, maintained and reproduced. It is an important platform for knowledge sharing within an organization or among peers in other settings. HN - 2024 MH - Compulsive Sexual Behavior Disorder UI - D000096583 MN - F1.145.527.100.120.375 MN - F3.835.750.500 MS - Persistent pattern of failure to control intense, repetitive sexual impulses or urges resulting in repetitive sexual behavior. Symptoms may include repetitive sexual activities becoming a central focus of the person’s life to the point of neglecting health and personal care or other interests, activities and responsibilities; numerous unsuccessful efforts to significantly reduce repetitive sexual behavior; and continued repetitive sexual behavior despite adverse consequences or deriving little or no satisfaction from it. (https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1630268048) HN - Compulsive Behavior (2018-2024) BX - Addictive Sex BX - Compulsive Sexual Behavior BX - Hypersexuality Disorder BX - Sex Addiction BX - Sexaholism BX - Sexual Addiction BX - Sexual Compulsiveness BX - Sexual Obsession MH - Continuous Glucose Monitoring UI - D000095583 MN - E1.370.225.124.100.203 MN - E1.370.374.228 MN - E1.370.520.150 MN - E5.200.124.100.203 MS - GLUCOSE MONITORING device that measures interstitial glucose concentration continuously throughout the entire day and night. It does not replace traditional HOME BLOOD GLUCOSE MONITORING. HN - 2024 BX - CGM Device BX - Continuous Glucose Monitoring Device MH - Coping Skills UI - D000097813 MN - F1.58.72 MN - F4.754.137.436 MS - Various techniques for actively managing a stressful event or situation. HN - 2024(1992) BX - Anticipatory Coping BX - Approach Coping BX - Behavioral Coping BX - Cognitive Coping BX - Constructive Coping BX - Coping Behavior BX - Coping Strategies BX - Coping Techniques BX - Primary Coping BX - Proactive Coping BX - Social Coping MH - Cough-Variant Asthma UI - D000096823 MN - C8.127.108.784 MN - C8.381.495.108.750 MN - C8.674.95.784 MN - C20.543.480.680.95.688 MS - Asthma which is characterized by CHRONIC COUGH that is nonproductive without other asthmatic symptoms, e.g., WHEEZING, and PAROXYSMAL DYSPNEA. Cough-variant asthma is accompanied by AIRWAY HYPERSENSITIVITY and may progress to classical asthma without treatment. HN - 2024 MH - Cyclophanes UI - D000097566 MN - D2.455.426.559.542 MS - Hydrocarbons consisting of aromatic unit(s) and cross-linked ansa chain(s), derived from two nonadjacent positions of the aromatic ring(s), e.g., p-cyclophane and m-cyclophane. HN - 2024 BX - Cyclophane MH - Cystitis, Hemorrhagic UI - D000096722 MN - C12.50.351.968.829.495.250 MN - C12.200.777.829.495.250 MN - C12.950.829.495.250 MS - A diffuse inflammation of the URINARY BLADDER characterized by HEMATURIA due to bleeding from the bladder mucosa. Hemorrhagic cystitis is most often associated with infections, e.g., HUMAN ADENOVIRUS INFECIONS, but may also be due to other noninfectious etiologies: CHEMOTHERAPY with certain drugs, e.g., CYCLOPHOSPHAMIDE and IFOSFAMIDE, and RADIOTHERAPY. HN - 2024 BX - Hemorrhagic Cystitis MH - Cytopenia UI - D000095542 MN - C15.378.243 MS - A deficiency in or reduction of the number of blood cells. HN - 2024 MH - Dammaranes UI - D000097669 MN - D2.455.849.919.208 MS - Tetracyclic triterpenes named after dammar resin, a natural resin first isolated from tropical trees of the DIPTEROCARPACEAE family. HN - 2024 (1997) BX - Dammarane BX - Dammarane-Type Triterpenes MH - Daphnia magna UI - D000096602 MN - B1.50.500.131.365.150.200.500 MS - A relatively large freshwater water flea with characteristic transparent chitin CARAPACE that extends into the head shields. It is found both in ephemeral rock pools, ponds and lakes. Daphnia magna is a model system for various ecological, ecotoxicological and biomedical studies. HN - 2024 MH - Daphnia pulex UI - D000096604 MN - B1.50.500.131.365.150.200.750 MS - A freshwater water flea with distinctly stout middle pecten of the postabdominal claw and small symmetrical polygonal markings on the rostrum. D. pulex and several closely related species such as D. pulicaria belong to what is sometimes known as D. pulex complex and can hybridize. Daphnia pulex is found ubiquitously and is often the most common species in ephemeral pools and is a model system for various ecological, ecotoxicological and biomedical studies. HN - 2024 BX - Common Water Flea BX - Daphnia pulicaria MH - Dashboard Systems UI - D000095489 MN - L1.224.900.280.500 MN - N4.452.515.110.500 MS - A platform that integrates multiple datasets, data structures, and sources into a single interface that is easily visualized and understood. HN - 2024 BX - Clinical Dashboard BX - Electronic Dashboard BX - Health Dashboard MH - Deaf Culture UI - D000096282 MN - I1.76.201.450.350.250 MN - I1.880.853.100.450.250 MS - Networking and deep connections within the Deaf community. Valuing the sign language of the region and supporting sign language use in educational settings, support of bilingual ASL/English programs, and use of technology to overcome traditional communication barriers. (https://nationaldeafcenter.org/resource-items/deaf-community-introduction/) HN - 2024 BX - Deaf Community MH - Degrons UI - D000097791 MN - G2.111.570.820.709.275.625 MS - Minimal elements within a protein that are sufficient for recognition and degradation by a proteolytic apparatus. Inherent degrons are comprised of short linear amino acid sequences and secondary protein structural features that increase the affinity to E3 LIGASE; and are involved in regulating the specificity and timing of PROTEIN DEGRADATION. Acquired degrons are mostly transient and conferred by post-translational modifications of specific amino acids within proteins. (From Mol Cell. 2016 Sep 15;63(6):1055-65) HN - 2024 BX - C-Degrons BX - D-Box Motif BX - Destruction Box BX - Destruction Box Motif BX - Destruction Boxes BX - N-Degrons BX - PEST Motif BX - PEST Sequence MH - delta-1-Pyrroline-5-Carboxylate Reductase UI - D000097502 MN - D8.811.682.662.695.500 MS - An enzyme that catalyzes the last step in proline biosynthesis which catalyzes the NADPH-dependent reduction of delta-1-pyrroline-5-carboxylate to L-Proline. HN - 2024 (1986) BX - L-Pro-NAD(P)-5-Oxidoreductase BX - P5C Reductase BX - P5CR Enzyme MH - Deltainfluenzavirus UI - D000097023 MN - B4.820.480.968.430 MS - A genus of the family ORTHOMYXOVIRIDAE comprising viruses similar to type C, lacking NEURAMINIDASE and using hemagglutinin-esterase fusion (HEF) protein for attachment. Unlike in other influenza virus genera viral NEP is not produced via alternatively spliced non-structural protein mRNA (NS1). Deltainfluenzavirus mostly infect nonhuman hosts, e.g., cattle and swine and in human causes acute febrile respiratory tract infection. Influenza D virus is the type species. HN - 2024(1994) BX - Deltainfluenzavirus influenzae BX - Influenza C like virus C-OK BX - Influenza D virus BX - Influenza Viruses Type D BX - Influenzavirus D BX - Orthomyxoviruses Type D MH - Dexpramipexole UI - D000097662 MN - D3.383.129.708.89.111 MN - D3.633.100.185.111 MS - The (R)-(+) enantiomer of PRAMIPEXOLE. Dexpramipexole has lower affinity for DOPAMINE RECEPTORS than pramipexole. HN - 2024; use PRAMIPEXOLE 2019-2023 BX - (6R)-4,5,6,7-Tetrahydro-N6-Propyl-2,6-Benzothiazole-Diamine BX - (R)-2-Amino-6-Propylamino-4,5,6,7-Tetrahydrobenzothiazole BX - (R)-Pramipexole BX - R-(+)-Pramipexole MH - Diet, Plant-Based UI - D000095500 MN - E2.642.249.278 MN - G7.203.650.240.278 MS - A diet that emphasizes consumption of plant foods, such as grains, fruits, vegetables, nuts, and LEGUMES while reducing intake of animal-based foods. HN - 2024; use DIET, VEGETARIAN 2020-2023 BX - Plant-Based Diet BX - Plant-Based Nutrition FX - Herbivory FX - Vegetarians MH - Dietary Patterns UI - D000095362 MN - G7.203.650.240.329 MN - G7.203.650.353.350 MS - Foods and beverages that an individual or group of humans or animals habitually consume. HN - 2024 BX - Dietary Pattern BX - Food Patterns MH - Digital Health UI - D000097103 MN - L1.313.375 MN - L1.462.500.847.125 MN - N4.590.374.178 MN - N5.300.291 MS - Use of digital technologies in medicine and other health professions to manage illnesses and health risks and to promote wellness; includes the use of WEARABLE DEVICES; HEALTH INFORMATION TECHNOLOGY; ELECTRONIC HEALTH RECORDS; TELEMEDICINE; and PERSONALIZED MEDICINE. HN - 2024 BX - Digital Health Technology FX - Precision Medicine FX - Telemedicine FX - Wearable Electronic Devices MH - Dignity Therapy UI - D000096225 MN - F4.754.286 MS - Evidence-based psychotherapeutic modality for patients who are classified as terminally ill. Such patients may have loss of autonomy, severe physical pain, and challenging existential and spiritual experience, which contribute to disintegration of patient's sense of self. HN - 2024 BX - Dignity Psychotherapy MH - Disability Discrimination UI - D000096222 MN - F1.145.813.550.328 MN - F1.145.813.629.531 MS - Discrimination against persons with physical, intellectual, or psychiatric disabilities. HN - 2024 BX - Ableism MH - Disaster Nursing UI - D000095582 MN - H2.478.676.194 MN - N2.421.533.188 MS - The specialty or practice of nursing in the care of patients at the site of a disaster. HN - 2024 FX - Disaster Medicine MH - DNA Damage Tolerance UI - D000097122 MN - G2.111.225.380 MN - G5.226.380 MS - Strategies that cells use to continue DNA replication when replicative DNA polymerases stall at DNA damage-blocked replication forks. These DNA damage tolerant replication mechanisms bypass the DNA DAMAGE, which may be repaired subsequently by various DNA REPAIR mechanisms. HN - 2024 BX - DNA Damage Bypass Pathways BX - DNA Damage Tolerance Pathways BX - DNA Damage Tolerant Replication BX - Post Replication Repair BX - Post-Replication Repair BX - Postreplication Repair BX - Postreplicative Repair BX - Postreplicative Template Switching BX - Replication Fork Reversal BX - Replication Template Switching FX - DNA Repair MH - DNA Methyltransferase 3B UI - D000097584 MN - D8.811.913.555.500.350.100.500.625 MS - A DNA (cytosine 5) Methyltransferase that has an essential role in the establishment of DNA methylation patterns during development. HN - 2024 (1999) MH - DNA Polymerase theta UI - D000097462 MN - D8.811.913.696.445.308.300.622 MS - A specialized DNA polymerase that in humans is encoded by the POLQ gene. It is involved in DNA repair pathways, including DNA END-JOINING REPAIR and RECOMBINATIONAL DNA REPAIR. HN - 2024 (1999) BX - DNA Polymerase POLQ MH - Dyrk Kinases UI - D000097603 MN - D8.811.913.696.620.682.700.288 MN - D8.811.913.696.620.682.725.37 MN - D12.776.476.563.288 MN - D12.776.476.568.37 MS - PROTEIN KINASES that can phosphorylate aromatic amino acid residue TYROSINE as well as aliphatic amino acid residues SERINE and THREONINE. HN - 2024 (1996) BX - Dual Specificity Protein Kinase Dyrk BX - Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A BX - Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1B BX - Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 2 BX - Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 3 BX - Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 4 BX - Dual Specificity Tyrosine-Phosphorylation Regulated Kinases BX - Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 4A BX - Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 4B MH - Echis UI - D000097185 MN - B1.50.50.286.875.875.875.750 MN - B1.50.150.900.833.672.125.937.875.750 MN - B1.50.150.900.833.672.562.875.875.750 MS - A genus of vipers found in Africa, Arabia and India. Echis snakes include venomous saw-scale viper and carpet viper. HN - 2024 MH - Ectodermal Placodes UI - D000097863 MN - A16.216 MS - A series of thickened ECTODERM patches in the developing cranial region that appears during week 4 in human embryo. Ectodermal placodes are the primordium of many ectodermal sensory systems including the INNER EAR, the EYE LENS, the OLFACTORY EPITHELIUM, as well as the PITUITARY GLAND and THYROID GLAND. HN - 2024 BX - Adenohypophyseal Placodes BX - Cranial Ectodermal Placodes BX - Neural Placodes BX - Neurogenic Placode BX - Olfactory Placodes BX - Optic Placodes BX - Otic Placodes MH - Edible Seaweeds UI - D000097342 MN - B5.80.750.225 MS - Various seaweeds either wild-harvested or cultured (AQUACULTURE) for direct human consumption. HN - 2024(2004) MH - Education, Biological and Biomedical Sciences, Graduate UI - D000096782 MN - I2.358.337.125 MS - Educational programs for graduates entering a master’s or PhD level biological and biomedical science graduate programs. HN - 2024 BX - Biological and Biomedical Sciences Graduate Education BX - Biological Sciences Graduate Education BX - Biomedical and Biological Sciences Graduate Education BX - Biomedical Sciences, Graduate Education BX - Education, Biological Sciences, Graduate BX - Education, Biomedical and Biological Sciences, Graduate BX - Education, Biomedical Sciences, Graduate BX - Graduate Education, Biological Sciences BX - Graduate Education, Biomedical Sciences MH - Efferocytosis UI - D000097242 MN - G4.11.688 MN - G4.417.350.545.500 MN - G9.188.665.500.500 MN - G12.450.564.809.500.500 MS - Phagocytosis and clearance of apoptotic cells. HN - 2024 BX - Apoptotic Cell Clearance MH - Ejaculatory Dysfunction UI - D000097910 MN - C12.100.500.150 MN - C12.100.875.364 MN - C12.200.294.150 MS - The inability in males to ejaculate, or to have a normal time to EJACULATION. HN - 2024 BX - Anejaculation BX - Delayed Ejaculation BX - Ejaculation Dysfunction BX - Ejaculatory Incompetence MH - Elastin-Like Polypeptides UI - D000097825 MN - D5.750.78.421.500 MN - D12.776.860.300.350.350 MN - D26.255.260.259 MN - E2.319.300.380.388 MS - Synthetic biopolymers that are formed by repeating amino acid sequences that are naturally found in TROPOELASTIN. They are useful for various purposes, including DRUG DELIVERY SYSTEMS, TISSUE SCAFFOLDS, and ANTINEOPLASTIC AGENTS. HN - 2024 BX - Elastin-Like Polypeptides (ELPs) MH - Emergency Room Visits UI - D000096924 MN - N2.421.297.127 MN - N2.421.585.294 MN - N4.452.289.500 MS - Visits made by patients to hospital emergency rooms for diagnosis and treatment. HN - 2024 BX - Emergency Department Visits BX - Hospital Emergency Department Visits MH - Emotional Exhaustion UI - D000097815 MN - C23.888.369.250 MN - F1.145.126.990.620 MN - F1.470.309 MN - F2.830.900.459 MS - A state of feeling emotionally overextended and drained. HN - 2024 BX - Emotional Fatigue MH - Endothelial-Mesenchymal Transition UI - D000096382 MN - G4.356.500.500 MS - Phenotypic changes of ENDOTHELIAL CELLS to MESENCHYME type during development or during disease states such as INFLAMMATION; CANCER; FIBROSIS or CARDIOVASCULAR DISEASE. HN - 2024 BX - EndMT BX - Endothelial-Mesenchymal Transformation MH - Enhancer RNAs UI - D000095499 MN - D13.444.735.790.100 MS - Noncoding RNAs transcribed from ENHANCER SEQUENCES. HN - 2024 BX - Enhancer RNA BX - eRNAs MH - Epicardial Adipose Tissue UI - D000095543 MN - A10.165.114.915 MS - A fat deposit localized between the MYOCARDIUM and the visceral layer of the serous PERICARDIUM. Epicardial adipose tissue is a risk factor for various CARDIOVASCULAR DISEASES. HN - 2024 BX - Epicardial Adipocytes BX - Epicardial Fat BX - Epicardial Fat Tissue BX - Epicardial Visceral Adipose Tissue BX - Intra-Pericardial Adipose Tissue BX - Intrapericardial Adipose Tissue BX - Intrapericardial Fat BX - Intrapericardial Fat Tissue BX - Pericoronary Adipose Tissue BX - Pericoronary Fat BX - Pericoronary Fat Tissue MH - ERRalpha Estrogen-Related Receptor UI - D000097983 MN - D12.776.826.750.350.87 MN - D12.776.930.778.350.500 MS - An orphan nuclear receptor that belongs to the ERR subfamily. It has enriched expression in tissues with high oxidative metabolic capacity. HN - 2024 (1996) BX - ERR1 Protein BX - Estrogen-Related Receptor 1 BX - Estrogen-Related Receptor alpha MH - ETS Translocation Variant 6 Protein UI - D000097764 MN - D12.776.260.665.50 MN - D12.776.260.703.400 MN - D12.776.624.664.700.175.50 MN - D12.776.930.720.50 MN - D12.776.930.780.766 MS - A transcriptional repressor in the ETS transcription factor family. Contains a unique ETS domain and HLH domain that can interfere with protein-protein interactions. HN - 2024 (1994) BX - ETS Variant Gene 6 (TEL Oncogene) Protein MH - Eukaryotic Translation Initiation Factor 5A UI - D000097574 MN - D12.644.360.325.150.300.500 MN - D12.776.476.325.150.300.500 MN - D12.776.835.725.868.750.500 MS - A component of eukaryotic initiation factor 5A that is involved in the elongation, termination, and stimulation of peptide bond formation. This factor is essential for cell proliferation HN - 2024 BX - Eukaryotic Initiation Factor-4D MH - Excision Repair UI - D000097147 MN - G2.111.222.460 MN - G5.219.460 MS - A major DNA repair mechanism in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand. HN - 2024; use DNA REPAIR 1991-2023 BX - Nucleotide Excision Repair BX - Transcription Coupled Excision Repair BX - Transcription Coupled Repair BX - Transcription-Coupled Excision Repair BX - Transcription-Coupled Repair MH - Excoriation Disorder UI - D000096705 MN - F1.145.126.980.375 MN - F3.80.600.125 MN - F3.250.150 MS - Compulsion to pick one's skin. HN - 2024 BX - Dermatillomania BX - Pathologic Skin Picking BX - Pathologic Skin Picking Disorder BX - Pathological Skin Picking Disorder BX - Skin Picking BX - Skin Picking Behaviors BX - Skin Picking Disorder MH - Exportin 1 Protein UI - D000097606 MN - D12.776.157.530.750.500.624 MN - D12.776.543.585.750.500.624 MN - D12.776.660.502.750 MN - D12.776.826.90 MS - A karyopherin that functions in nuclear export of proteins and several classes of RNAs. HN - 2024: use KARYOPHERINS 2021-2023 BX - Chromosome Region Maintenance 1 Protein BX - Exportin 1 MH - Extravillous Trophoblasts UI - D000097862 MN - A11.382.992.500 MN - A16.254.500.766.500 MN - A16.710.802.500 MS - Differentiated trophoblast cells originally from trophoblastic cell columns of anchoring CHORIONIC VILLI of the DECIDUA basalis of the PLACENTA. Extravillous trophoblasts invade into the uterine structures, attaching the placenta to the UTERUS. They are also found in chorionic plate, MYOMETRIUM, and spiral arteries. HN - 2024 MH - Ficolins UI - D000097604 MN - D12.776.503.210 MS - Soluble oligomeric defense proteins with lectin-like activity. They initiate the LECTIN pathway of COMPLEMENT ACTIVATION through attached serine proteases and a primitive OPSONIZATION. HN - 2024 (1993) BX - Collagen-Fibrinogen Domain Containing Lectins BX - Ficolin A BX - Ficolin-A BX - Ficolin-alpha BX - Ficolin-beta BX - Hucolin BX - L-Ficolin BX - M-Ficolin MH - Fire Ants UI - D000097582 MN - B1.50.50.286.250 MN - B1.50.500.131.617.720.500.500.875.205.500 MS - Two members of ant genus Solenopsis in the family Formicidae, order Hymenoptera, accidentally introduced into the United States at Mobile, Alabama. Fire ants are now found in many states from California to Florida. Fire ant bites typically cause a burning sensation, welts and blisters but can cause systemic or life-threatening reactions. HN - 2024 BX - Black Imported Fire Ant BX - Imported Black Fire Ant BX - Imported Fire Ants BX - Imported Red Fire Ant BX - Red Imported Fire Ant BX - Solenopsis invicta BX - Solenopsis richteri MH - First Generation Cephalosporins UI - D000097904 MN - D27.505.954.122.85.386.500 MS - CEPHALOSPORIN agents with excellent coverage against gram-positive cocci, such as STAPHYLOCOCCUS and STREPTOCOCCUS. They have some activity against the gram-negative bacteria, but in general, gram-negative activity is decreased compared to 2nd, 3rd, and 4th generation cephalosporins. HN - 2024 BX - First Generation Cephalosporin MH - Flighted Spongy Moth Complex UI - D000097664 MN - B1.50.500.131.617.720.500.500.937.650.50 MS - Asian moths known to cause extensive damage in trees and shrubs by defoliation. Flighted spongy moth complex females are active fliers unlike spongy moths of European origin, enabling their rapid spread. HN - 2024 BX - Asian Gypsy Moth BX - Asian Gypsy Moths BX - Asian Spongy Moth BX - Lymantria albescens BX - Lymantria dispar BX - Lymantria dispar asiatica BX - Lymantria dispar japonica BX - Lymantria post-alba BX - Lymantria postalba BX - Lymantria umbrosa BX - Phalaena dispar BX - Porthetria umbrosa MH - Fluoride Treatment UI - D000097182 MN - E6.761.382.500 MS - The topical application of fluorides, usually in pastes, gels, varnishes, TOOTHPASTES or MOUTHWASHES, to reduce the incidence of DENTAL CARIES. Fluoride Treatment may occur in the dental office or at home. (https://jada.ada.org/article/S0002-8177(14)62166-8/fulltext) HN - 2024 BX - Fluoride Application BX - Fluoride Application, Topical FX - Fluorides, Topical MH - Food Loss and Waste UI - D000097798 MN - D20.944.190 MN - J1.576.423.350 MN - N6.850.460.710.285 MS - Reductions in edible FOOD post-harvesting anywhere along the food supply chain, e.g., due to spoilage, improper storage, excessive food preparation, resulting in REFUSE DISPOSAL of potentially useful food mass. HN - 2024 BX - Food Loss BX - Food Waste BX - Food Waste and Loss MH - Forensic Imaging UI - D000097785 MN - E1.370.350.295 MN - I1.198.780.922 MS - The use of various imaging and image enhancement techniques in forensic investigative disciplines. It often includes FORENSIC MEDICINE platforms such as X-RAYS; CT XRAY; and MRI. HN - 2024 BX - Forensic Radiology FX - Postmortem Imaging MH - Frataxin UI - D000096923 MN - D12.776.157.427.374.375.959 MN - D12.776.556.579.374.375.789 MN - D12.776.575.609 MS - A protein involved in the transfer of iron and sulfur to iron-sulfur cluster (ISC) assembly complex for de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. Deficiency leads to the neurodegenerative disease FRIEDREICH ATAXIA. HN - 2024 (1996) BX - Frataxin Protein BX - Friedreich Ataxia Protein BX - FXN Frataxin MH - Fundulus heteroclitus UI - D000096403 MN - B1.50.150.900.493.850.280.214.500 MN - B1.50.150.900.493.850.280.500.500 MS - A killifish species in topminnows genus Fundulus which is native to Atlantic saltwater marshes and tidal creeks. It is commonly known as mummichog or Atlantic killifish. Fundulus heteroclitus is a model organism for toxicogenomics and related fields because of its high resistance to environmental toxins; short intervals between spawning (10 days); large number of eggs (up to 300 each spawning) and relatively long lifespan (4 years). HN - 2024(2002) BX - Cobitis heteroclita heteroclita BX - Cobitis macrolepidota BX - Fundulus heteroclitus heteroclitus BX - Fundulus heteroclitus macrolepidotus BX - Mummichog MH - GADD45 Proteins UI - D000097642 MN - D12.776.167.254 MN - D12.776.660.338 MS - Nuclear proteins that act as critical stress sensors that mediate various cellular responses, including DNA REPAIR; CELL CYCLE ARREST; and APOPTOSIS. HN - 2024 (1994) BX - Gadd45 gamma Protein BX - GADD45G Protein BX - Growth Arrest and DNA-Damage-Inducible 45 gamma Protein MH - Galactoside 2-alpha-L-fucosyltransferase UI - D000097631 MN - D8.811.913.400.450.300.500 MS - Catalyzes the transfer of L-fucose to the terminal galactose residue of glycoconjugates through an alpha-(1,2) linkage leading to H antigen synthesis. HN - 2024 (1977) BX - Blood Group H alpha-2-fucosyltransferase BX - Blood Group H Fucosyltransferase BX - Galactoside 2-fucosyltransferase BX - Guanosine Diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase BX - Secretor Blood Group alpha-2-fucosyltransferase MH - Ganglionic Eminence UI - D000097803 MN - A8.186.211.200.885.287.500.420.500 MN - A16.254.875 MS - A transitory embryonic structure that appears during the 5th week post-fertilization. The ganglionic eminence plays an important in the development of the nervous system by guiding tangential cell and axon migration during embryonic development and give rise to BASAL GANGLIA and cortical GABAergic and thalamic and olfactory INTERNEURONS. HN - 2024 BX - Ganglionic Eminences BX - Ventricular Eminences MH - Gap Junction alpha-4 Protein UI - D000097006 MN - D12.776.543.585.250.300 MS - A GAP JUNCTION alpha subunit containing four transmembrane domains expressed in the adipose cells and myocardium. Mutations in the human gene GJA4 are risk factors for ATHEROSCLEROSIS and MYOCARDIAL INFARCTION. HN - 2024(2008) BX - Connexin 37 BX - Connexin 37 Protein BX - Gap Junction A4 BX - Gap Junction alpha4 Protein BX - GJA4 Protein MH - Gap Junction alpha-5 Protein UI - D000097003 MN - D12.776.543.585.250.400 MS - A GAP JUNCTION alpha subunit containing four transmembrane domains expressed in the atrial myocardium and ventricular HEART CONDUCTION SYSTEM including PURKINJE FIBERS. Mutations in the human gene GJA5 are associated with cardiac conduction abnormalities such as a familial ATRIAL FIBRILLATION. HN - 2024(2010) BX - Connexin 40 BX - Connexin 40 Protein BX - Gap Junction A5 BX - Gap Junction alpha5 Protein BX - GJA5 Protein MH - Gap Junction beta-1 Protein UI - D000097002 MN - D12.776.543.585.250.600 MS - A GAP JUNCTION beta subunit containing four transmembrane domains expressed in myelinating SCHWANN CELLS and is localized to peripheral MYELIN (e.g., noncompact myelin in the paranode and Schmitt-Lanterman incisures). Mutations in the human gene GJB1 are associated with X-linked CHARCOT-MARIE-TOOTH DISEASE type 1 (CMT1X). HN - 2024(1993) BX - Connexin 32 BX - Connexin 32 Protein BX - Cx32 Protein BX - Gap Junction B1 BX - Gap Junction beta1 Protein BX - GJB1 Protein MH - Gap Junction delta-2 Protein UI - D000097004 MN - D12.776.543.585.250.800 MS - A GAP JUNCTION delta subunit containing four transmembrane domains expressed in the PANCREATIC BETA CELLS, retinal CONE PHOTORECEPTOR CELLS, hippocampal INTERNEURONS, and dendrites in the OLIVARY NUCLEUS and THALAMIC NUCLEI. HN - 2024(2000) BX - Connexin 36 BX - Connexin 36 Protein BX - Gap Junction D2 BX - Gap Junction Protein delta 2 BX - GJD2 Protein MH - Gender-Affirming Care UI - D000097962 MN - N4.590.374.268 MN - N5.300.361 MS - A supportive healthcare, consisting of medical, surgical, mental health, and non-medical services for TRANSGENDER PERSONS and GENDER-NONCONFORMING PERSONS. Medical and psychosocial gender affirming healthcare practices may lower rates of adverse mental health outcomes, build SELF ESTEEM, and improve overall QUALITY OF LIFE for transgender and gender diverse youth (https://opa.hhs.gov/sites/default/files/2022-03/gender-affirming-care-young-people-march-2022.pdf). HN - 2024 BX - Gender-Affirmative Care BX - Gender-Affirming Healthcare BX - Gender-Confirming Care MH - Gender-Nonconforming Persons UI - D000096224 MN - M1.270.988.188 MS - Individuals whose external manifestation of their gender identity does not conform to society’s expectations of GENDER ROLES. Persons whose gender expression differs from conventional expectations of masculinity and femininity. HN - 2024 BX - Gender Non conforming BX - Gender Non-conforming People BX - Non-Binary Persons FX - Gender Identity FX - Transgender Persons MH - Genetic Risk Score UI - D000096442 MN - C23.550.291.687.500.750 MN - E5.318.740.600.800.725.250 MN - G5.380.355.500 MN - N5.715.360.750.625.700.700.250 MN - N6.850.520.830.600.800.725.250 MS - Estimate of an individual's genetic liability to a trait or disease, calculated according to their genotype profile and relevant genome-wide association study data. (from Tutorial: a guide to performing polygenic risk score analyses. Nat Protoc. 2020 Sep;15(9):2759.) HN - 2024 BX - Polygenic Risk Score MH - Geriatric Anesthesia UI - D000097870 MN - E3.155.253 MS - Conducting anesthesia procedures in AGED adults, typically those aged 65 years and older. HN - 2024 BX - Anesthesia, Geriatric BX - Anesthesia, Geriatrics MH - Ginkgo Extract UI - D000096983 MN - D20.215.784.500.375 MS - Preparations of GINKGO BILOBA. They contain various ANTIOXIDANTS including FLAVONOIDS and TERPENES (e.g., XANTHOPHYLLS). HN - 2024 MH - Glucagon-Like Peptide-1 Receptor Agonists UI - D000097789 MN - D27.505.696.422.125 MS - Compounds that stimulate the activity of GLUCAGON-LIKE PEPTIDE-1 RECEPTOR. Glucagon-like peptide-1 receptor agonists are used to treat TYPE 2 DIABETES and OBESITY. HN - 2024 BX - GLP-1 Analogs BX - GLP-1 Receptor Agonists BX - Incretin Mimetics MH - GluK2 Kainate Receptor UI - D000097806 MN - D12.776.157.530.400.400.500.200.500 MN - D12.776.543.550.450.500.200.200.500 MN - D12.776.543.585.400.500.200.200.500 MN - D12.776.543.750.720.200.450.400.200.500 MS - A high-affinity KAINATE and GLUTAMATE receptor that functions as ligand-gated ion channel in the CENTRAL NERVOUS SYSYEM and plays an essential role in NEURONAL PLASTICITY. HN - 2024 (1996) BX - GluR6 Kainate Receptor BX - GluR6 Kainate Receptors BX - GluR6 Receptor BX - Ionotropic Glutamate Receptor GluR6 MH - GluK3 Kainate Receptor UI - D000097808 MN - D12.776.157.530.400.400.500.200.750 MN - D12.776.543.550.450.500.200.200.750 MN - D12.776.543.585.400.500.200.200.750 MN - D12.776.543.750.720.200.450.200 MN - D12.776.543.750.720.200.450.400.200.750 MS - A high-affinity KAINATE and GLUTAMATE receptor that functions as ligand-gated ion channel in the CENTRAL NERVOUS SYSYEM and modulates excitatory synaptic transmission. HN - 2024 (1995) BX - EAA5 Receptor BX - EAA5 Receptors BX - GluR7 Receptor MH - Glyphosate UI - D000097797 MN - D2.705.400.321 MN - D12.125.481.400 MS - Active compound in herbicidal formulations that inhibits 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE. HN - 2024 (1976) BX - Gliphosate BX - Glyphosate Hydrochloride (2:1) BX - Glyphosate, Calcium Salt BX - Glyphosate, Calcium Salt (1:1) BX - Glyphosate, Copper (2+) Salt BX - Glyphosate, Dilithium Salt BX - Glyphosate, Disodium Salt BX - Glyphosate, Magnesium Salt BX - Glyphosate, Magnesium Salt (2:1) BX - Glyphosate, Monoammonium Salt BX - Glyphosate, Monopotassium Salt BX - Glyphosate, Monosodium Salt BX - Glyphosate, Sodium Salt BX - Glyphosate, Zinc Salt BX - Yerbimat MH - Green Light UI - D000096585 MN - G1.358.500.505.650.836.500 MN - G1.590.540.387 MN - G1.750.250.650.836.500 MN - G1.750.770.578.836.500 MS - That portion of the electromagnetic spectrum with wavelengths between 495 to 570 nm. HN - 2024 MH - Haemaphysalis longicornis UI - D000097622 MN - B1.50.500.131.166.132.832.400.313 MS - A species of tick (TICKS) in the family IXODIDAE, distributed in AUSTRALASIA but establishing in the Eastern UNITED STATES. It is an aggressive biter and can cause severe infestations in livestock. It is also a known/suspected vector of various livestock and human diseases. HN - 2024 BX - Asian Long Horned Tick BX - Long Horned Tick MH - Health Services for Prisoners UI - D000096245 MN - N2.421.755 MS - Health services provided for PRISONERS. The services include the promotion of health and the delivery of health care. HN - 2024 BX - Prison Health Services BX - Prisoner Health Services BX - Prisoner's Health Services MH - Hearing Loss, Hidden UI - D000097942 MN - C9.218.458.341.975 MN - C10.597.751.418.341.975 MN - C23.888.592.763.393.341.975 MS - Hearing loss that is difficult to diagnose by standard hearing tests as it most often pertains to difficulties in hearing only in certain situations such as in noisy environments. HN - 2024 BX - Auditory Synaptopathy BX - Cochlear Synaptopathy BX - Hidden Hearing Loss BX - Noise-Induced Cochlear Synaptopathy MH - Helicoverpa armigera UI - D000097666 MN - B1.50.500.131.617.720.500.500.937.650.207 MS - Widely distributed old world bollworm which bore into the wide variety of host’s flowers and fruit and feed within the plant. Old world bollworm was detected in Puerto Rico in 2014 and Florida in 2015 but now eradicated in the United States. HN - 2024 BX - American Bollworm BX - Corn Ear Worm BX - Heliothis (Helicoverpa) armigera BX - Heliothis armigera BX - Noctua armigera BX - Old World Bollworm BX - Tobacco Budworm MH - Heloderma suspectum UI - D000097282 MN - B1.50.50.286.625 MN - B1.50.150.900.833.393.250 MS - Large nocturnal, venomous lizard found in the deserts of the Southwestern United States and northern Mexico. A synthetic version of Gila monster venom component exendin-4 is EXENATIDE. HN - 2024 BX - Banded Gila Monster BX - Heloderma suspectum cinctum BX - Heloderma suspectum suspectum BX - Reticulate Gila Monster MH - Hemosiderosis, Pulmonary UI - D000097545 MN - C8.381.367 MN - C18.452.565.500.500.500 MS - Iron deposition within the lung. Primary pulmonary hemosiderosis is characterized by HEMOPTYSIS; IRON-DEFICIENCY ANEMIA, and diffuse pulmonary hemorrhage as seen as transient pulmonary infiltrates on RADIOGRAPHY. Even though large amounts of iron are laid down in the lung, with normal or increased total body iron, anemia occurs because of inability of the erythron to use iron sequestered in pulmonary MACROPHAGES. HN - 2024(2010) BX - Idiopathic Pulmonary Hemosiderosis BX - Primary Pulmonary Hemosiderosis BX - Pulmonary Hemosiderosis BX - Secondary Pulmonary Hemosiderosis MH - Himalayas UI - D000096266 MN - Z1.252.245.782.813 MS - Mountain system in southern Asia that forms a barrier between the Plateau of Tibet to the north and the plains of the Indian subcontinent to the south. It constitutes the greatest mountain system on Earth and includes more than 110 peaks rising to elevations above 24,000 feet, including Mount Everest. The system extends some 1,550 miles to west and covers about 230,000 sq miles. Between the eastern and western extremities are several provinces of INDIA and the kingdoms of NEPAL and BHUTAN. The glaciers and snows are the source of 19 major rivers, including the Indus, Ganges (Ganga), and Brahmaputra. (www.britannica.com/place/Himalayas, accessed 12/30/2022) HN - 2024 BX - Himalaya Mountain Range BX - Himalayan Mountain Range BX - Himalayan Mountains MH - HLA-E Antigens UI - D000097625 MN - D9.400.430.890.489.850 MN - D12.776.395.550.489.850 MN - D12.776.543.550.439.850 MN - D23.50.301.500.100.850 MN - D23.50.705.552.100.850 MS - Class I human histocompatibility (HLA) antigens encoded by genes at the E locus on chromosome 6. They bind a restricted subset of peptides derived from the leader peptides of other class I molecules. They primarily are involved with down-regulating cytolytic activity of NK CELLS and restricting non-canonical CD8-POSITIVE T LYMPHOCYTES. HN - 2024 (1988) BX - HLA E Antigens MH - Home Schooling UI - D000096682 MN - I2.531 MS - It is a program of regular, through instruction during the school year in the studies usually taught in public and private schools to children of the same age. (https://dsd.maryland.gov/regulations/pages/13a.10.01.01.aspx) HN - 2024 BX - Homeschool BX - Homeschooling MH - Homeobox Protein PITX2 UI - D000097577 MN - D12.776.260.400.228 MN - D12.776.930.320 MS - A homeodomain transcription factor involved in cardiac development. HN - 2024 (1996) BX - Pituitary Homeobox 2 Protein MH - Homeobox Protein SIX3 UI - D000097607 MN - D12.776.260.400.242 MN - D12.776.306.450 MN - D12.776.631.530 MS - A homeodomain protein that functions in embryonic eye and forebrain development. HN - 2024 (1996) BX - Sine Oculis Homeobox Homolog 3 Protein BX - SIX3 Protein MH - Honor-Based Violence UI - D000096242 MN - I1.198.240.856.350.570 MN - I1.198.240.856.463.500 MS - Crimes against a family member which are, or have been, justified by the perpetrators to protect the honor of the family. The targets may be children or adults of either gender. HN - 2024 BX - Honor Crime BX - Honor Crimes BX - Honor Killing MH - Host Tropism UI - D000096502 MN - G6.462.380.500 MN - G7.443 MN - G16.527.200.380.500 MS - The specificity of certain pathogens for infecting a particular type of cell or tissue. HN - 2024 (2009) BX - Amphotropic BX - Amphotropic Host Range BX - Amphotropism BX - Bacterial Tropism BX - Ecotropic Host Range BX - Ecotropism BX - Pantropic Host Range BX - Pantropism BX - Species Tropism MH - Hypertensive Crisis UI - D000096003 MN - C14.907.489.723 MS - A severe, acute increase in BLOOD PRESSURE that may result in STROKE or MYOCARDIAL ISCHEMIA. HN - 2024 BX - Hypertensive Emergency BX - Hypertensive Urgency MH - Immune System Exhaustion UI - D000095842 MN - G12.590 MS - A spectrum of functional deterioration in various lymphocyte populations that is induced by continuous antigenic stimulation. There are overlapping similarities with CELLULAR SENESCENCE; IMMUNOSENESCENCE; T-CELL SENESCENCE; and CLONAL ANERGY. HN - 2024 BX - B-Cell Exhaustion BX - Immune Exhaustion BX - Lymphocyte Exhaustion BX - Monocyte Exhaustion BX - NK Cell Exhaustion BX - Poly-Lymphocyte Exhaustion MH - Immunoinformatics UI - D000095763 MN - H1.158.273.180.475 MN - H2.403.44.750 MN - L1.313.124.250 MS - The interface between INFORMATICS and IMMUNOLOGY. Otherwise known as computational immunology, it is the use of computational methods and resources for studying IMMUNE SYSTEM PHENOMENA. HN - 2024 BX - Computational Immunology BX - Systems Immunology MH - Imprinting Disorders UI - D000096803 MN - C16.320.447 MS - Disorders caused by transcriptional silencing of one parental gene allele (imprinted gene). Imprinted genes show genetic expression from only one parent of the gene pair through epigenetic processes with no change in the DNA sequence. HN - 2024 BX - Genetic Imprinting Disorders BX - Genomic Imprinting Disorders BX - Imprinting Diseases BX - Imprinting Syndromes MH - In Vitro Meat UI - D000096904 MN - G7.203.300.600.250 MN - J2.500.600.250 MS - Meat produced by growing MUSCLE CELLS isolated from animal muscle tissue, in THREE-DIMENSIONAL CELL CULTURE. HN - 2024 BX - Cell-Based Meat BX - Cultivated Meat BX - Cultured Meat BX - Lab-Grown Meat BX - Laboratory-Grown Meat MH - Incarceration UI - D000097787 MN - I1.880.604.501 MN - I1.880.735.433 MS - The state of being imprisoned or confined. HN - 2024 BX - Imprisonment BX - Solitary Confinement of Prisoners MH - Indolosesquiterpenes UI - D000097848 MN - D2.455.849.765.674.250 MN - D3.633.100.473.416 MN - D4.663.250 MS - Sesquiterpene compounds that contain an INDOLE. HN - 2024 BX - Indole Sesquiterpenes MH - Inferior Olivary Complex UI - D000095746 MN - A8.186.211.132.810.591.500.430 MN - A8.186.211.132.810.591.750.250 MS - A brainstem nucleus in the superior medulla and a part of the OLIVARY NUCLEUS complex. Inferior olivary complex integrates motor and proprioceptive inputs and provides feedback to cerebellar neurons. HN - 2024 BX - Complexus Olivaris Inferior BX - Dorsal Accessory Olivary Nuclei BX - Dorsal Accessory Olivary Nucleus BX - Dorsal Accessory Olives BX - Inferior Olivary Body BX - Inferior Olivary Nuclei BX - Inferior Olivary Nucleus BX - Medial Accessory Olivary Nuclei BX - Medial Accessory Olivary Nucleus BX - Medial Accessory Olive BX - Olivary Complex Inferior BX - Principal Olivary Nuclei BX - Principal Olivary Nucleus BX - Principal Olive MH - Influenza A Virus, H5N6 Subtype UI - D000097025 MN - B4.820.480.968.405.400.552 MS - A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 6. The H5N6 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. H5N6 does not usually infect humans, but some cases have been reported with high mortality rate similar to another highly pathogenic avian influenza A(H5) virus H5N1 AVIAN INFLUENZA VIRUS. HN - 2024 BX - H5N6 Avian Influenza Virus BX - H5N6 subtype BX - H5N6 Virus MH - Inosine Triphosphatase UI - D000097630 MN - D8.811.277.40.600.500 MS - A pyrophosphatase that catalyzes the conversion of inosine triphosphate and deoxy-inosine triphosphate to inosine monophosphate and deoxy-inosine monophosphate, respectively. HN - 2024 (1975) BX - Inosine Triphosphate Pyrophosphohydrolase BX - ITP Pyrophosphohydrolase MH - Insulin-Like Peptides UI - D000096764 MN - D12.644.276.742 MN - D12.776.467.742 MN - D23.529.742 MS - Peptides that include INSULIN-LIKE GROWTH FACTOR 1 (IGF1), and IGF2. They influence brain development through their effects on CELL PROLIFERATION; CELL SURVIVAL; and NEUROGENESIS. They also influence post-embryonic development by serving as HORMONES; NEUROTRANSMITTERS, and GROWTH FACTORS. HN - for INSULIN-LIKE GROWTH FACTORS use SOMATOMEDINS 2022-2024 BX - Central ILPs BX - Central Insulin-Like Peptides BX - Insulin Like Growth Factor BX - Insulin Like Peptides BX - Insulin-Like Growth Factor BX - Insulin-Like Growth Factors BX - Insulin-Like Peptides (ILPs) BX - Peripheral ILPs BX - Peripheral Insulin-Like Peptides MH - Interferon gamma Receptor UI - D000096743 MN - D12.776.543.750.705.852.400.250 MS - A heterodimeric receptor composed of two subunits IFNGR1 and IFNGR2. Activated IFNGR1 subunit is believed to form a docking site for SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1). IFNGR2 associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). HN - 2024 (1993) BX - CD119 Antigen BX - CDw119 Antigen BX - IFN-gamma Receptor 1 BX - IFNGR2 Protein BX - Interferon gamma Receptor 2 BX - Interferon gamma Receptors BX - Receptor, Interferon gamma MH - Interleukin-22 UI - D000097043 MN - D12.644.276.374.465.925 MN - D12.776.467.374.465.925 MN - D23.529.374.465.925 MS - An interleukin that plays a critical role in modulating tissue responses during inflammation, and in WOUND HEALING. HN - 2024 (2000) BX - Cytokine Zcyto18 BX - IL-10-Related T-Cell-Derived-Inducible Factor BX - IL-22 BX - ILTIF MH - Intestinal Barrier Function UI - D000095644 MN - G3.143.464 MN - G10.261.454 MS - The role of the intestinal wall as a selective barrier defending against infiltration of bacteria and toxic molecules while allowing the passage or transport of nutrients, electrolytes, and water. HN - 2024 BX - Intestinal Barrier Permeability BX - Intestinal Mucosa Barrier Function BX - Intestinal Mucosa Barrier Permeability BX - Intestinal Mucosa Permeability BX - Intestinal Mucosal Barrier Function BX - Intestinal Mucosal Barrier Permeability BX - Intestinal Mucosal Permeability BX - Intestinal Permeability FX - Intestinal Absorption MH - Intracameral Injection UI - D000097807 MN - E2.319.267.530.475.250 MS - A medical procedure in which medication is delivered directly into the ANTERIOR CHAMBER of the eye. HN - 2024 BX - Anterior Chamber Injection BX - Intra-Cameral Injection BX - Intracameral (IC) Injection MH - Iodothyronine Deiodinase Type II UI - D000097564 MN - D8.811.682.732.525.500 MS - An enzyme responsible for T4 (3,5,3',5'-tetraiodothyronine) to T3 (3,5,3'-TRIIODOTHYRONINE) conversion. May contribute to increasing T3 THYROID HORMONE production in patients with GRAVES DISEASE. HN - 2024 (1996) BX - DIO2 Enzyme BX - Selenodeiodinase Type 2 BX - TXDI2 Enzyme BX - Type 2 Deiodinase (D2) BX - Type 2 Selenodeiodinase BX - Type II 5'-Deiodinase BX - Type II Iodothyronine Deiodinase MH - Job Security UI - D000097814 MN - N1.824.245.475 MS - The extent to which job separations are involuntary. The primary measure of job security is the rate of job loss (https://www.bls.gov/osmr/research-papers/2002/pdf/ec020050.pdf). HN - 2024(2017) BX - Employment Retention BX - Employment Security BX - Employment Stability BX - Employment Tenure BX - Job Insecurity BX - Job Retention BX - Job Stability BX - Job Tenure MH - K Cl- Cotransporters UI - D000096922 MN - D12.776.157.530.450.625.875.500 MN - D12.776.157.530.937.572 MN - D12.776.543.585.450.625.171 MN - D12.776.543.585.937.657 MS - A subclass of symporters that specifically transport POTASSIUM and CHLORIDE ions across cellular membranes. Potassium chloride cotransporters play roles in regulating cell volume and intracellular chloride concentration. HN - 2024(1989) BX - Electroneutral Potassium-Chloride Co-transporter 3 BX - Electroneutral Potassium-Chloride Cotransporter 3 BX - K Cl- Co-transporters BX - K(+), Cl(-)-Co-transporters BX - K(+), Cl(-)-Cotransporters BX - K-Cl Co-transporter BX - K-Cl Co-transporter 3 BX - K-Cl Cotransporter BX - K-Cl Cotransporter 3 BX - KCC2 Co-transporter BX - KCC2 Cotransporter BX - KCC3 Co-transporter BX - KCC3 Cotransporter BX - KCC4 Co-transporter BX - KCC4 Cotransporter BX - Potassium-Chloride Co-transporter 2 BX - Potassium-Chloride Co-transporter 4 BX - Potassium-Chloride Co-transporters BX - Potassium-Chloride Cotransporter 2 BX - Potassium-Chloride Cotransporter 4 BX - Potassium-Chloride Cotransporters BX - Potassium-Chloride Symporters BX - SLC12A5 Protein BX - SLC12A6 Protein BX - SLC12A7 Protein BX - Solute Carrier Family 12 Member 5 BX - Solute Carrier Family 12 Member 6 BX - Solute carrier family 12 member 7 MH - Kalinin UI - D000097794 MN - D9.400.430.890.530.500 MN - D12.776.395.550.530.500 MN - D12.776.543.550.500.500 MN - D12.776.860.300.675.500 MS - An epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. Consists of 3 subunits (A, B2, & B1). HN - 2024 (1992) BX - Epiligrin BX - Kalinin B1 BX - Laminin 332 BX - Laminin 5 BX - Laminin B1k BX - Laminin-5 BX - Laminin-5 beta3 Protein BX - Nicein MH - Kir5.1 Channel UI - D000097062 MN - D12.776.157.530.400.600.450.525 MN - D12.776.543.550.450.750.450.525 MN - D12.776.543.585.400.750.450.525 MS - An inwardly-rectifying potassium channel that allows potassium to flow into rather than out of a cell. It selectively co-assembles with two other inward-rectifier type potassium channels, Kir4.1 or Kir4.2, to form heteromeric channels. HN - 2024 (2004) BX - Inward Rectifier K(+) Channel Kir5.1 BX - Inward Rectifier Potassium Channel 16 BX - KCNJ16 Protein MH - Lacanian Theory UI - D000095494 MN - F2.739.594 MS - Psychoanalytic theory begun by Jacques Lacan as a philosophical linguistic re-interpretation of Freud's original teachings. HN - 2024 MH - Lamin B Receptor UI - D000097682 MN - D8.811.682.660.495 MN - D12.776.826.187 MS - A 58 kDa membrane protein and delta(14)-sterol reductase that is found in the NUCLEAR ENVELOPE. Deficiencies of this receptor cause PELGER-HUET ANOMALY. HN - 2024 (1990) BX - Lamin B Receptors BX - p58 Receptor, Lamin B FX - Receptors, KIR MH - Left Atrial Appendage Closure UI - D000097546 MN - E2.148.442.582 MN - E5.157.250.582 MS - A procedure that blocks the left ATRIAL APPENDAGE to reduce the risk of MYOCARDIAL INFARCTION associated with ATRIAL FIBRILLATION (AF). The left atrial appendage is often the site of BLOOD CLOT formation in AF. HN - 2024 BX - LAA Closure BX - Left Atrial Appendage Occlusion Intervention MH - Legumins UI - D000097793 MN - D12.776.765.510 MS - CASEIN-like globular storage proteins from leguminous seeds such as peas. HN - 2024: LEGUMINS was LEGUMIN PROTEIN, PLANT 1978-2023 BX - Legumin BX - Legumin Protein MH - Liquid Chromatography-Mass Spectrometry UI - D000097922 MN - E5.196.181.400.777 MN - E5.196.566.575 MS - A microanalytical technique combining mass spectrometry and liquid chromatography for the qualitative as well as quantitative determinations of compounds. HN - 2024 BX - High Performance Liquid Chromatography-Mass Spectrometry BX - High Pressure Liquid Chromatography-Mass Spectrometry BX - HPLC-MS BX - LC-MS BX - Ultra Performance Liquid Chromatography-Mass Spectrometry BX - Ultra-Performance Liquid Chromatography-Mass Spectrometry BX - UPLC-MS MH - Lobesia botrana UI - D000097663 MN - B1.50.500.131.617.720.500.500.937.650.313 MS - A species of tortrix or leafroller moths of the family Tortricidae. These insects cause significant agricultural damage throughout the world feeding on the flower or fruit of host plants, most often grapes (VITIS VINIFERA). HN - 2024 BX - European Grape Vine Moth BX - European Grapevine Moth MH - Maggot Debridement Therapy UI - D000096383 MN - E2.95.533 MS - Medical use of live MAGGOTS for cleaning non-healing wounds. HN - 2024 BX - Larva Therapy BX - Larvae Therapy BX - Larval Debridement Therapy BX - Larval Therapy BX - Maggot Therapy MH - Magnetic Resonance Myelography UI - D000095497 MN - E1.370.350.578.937.505.500 MN - E1.370.350.700.560.505.500 MN - E1.370.350.825.500.633 MN - E1.370.376.537.750.505.500 MN - E5.629.937.505.500 MS - A modified magnetic resonance imaging method for generating myelogram like images, characterized by high signal intensity of the CEREBROSPINAL FLUID, which permits visualization of spinal subarachnoid spaces and nerve root sheaths. HN - 2024 BX - Heavily T2-Weighted Magnetic Resonance Myelography BX - Heavily T2-Weighted MRM BX - HT2W-MRM BX - MR Myelography BX - MRI Myelography MH - Mandatory Vaccination UI - D000095498 MN - I1.880.604.622.750 MN - N3.706.657.750 MS - Vaccination compelled by direct or indirect threat of restrictions in cases of non-compliance. HN - 2024 BX - Compulsory Vaccination BX - Mandated Vaccination BX - Vaccine Mandate MH - Mass Shooting Events UI - D000097907 MN - I1.198.240.470.786 MN - I1.198.240.856.519.500 MN - I1.198.240.856.800.537.500 MN - I1.880.735.344.750 MN - I1.880.735.900.632.500 MN - I1.880.735.900.800.575.500 MN - N6.230.100.160.500 MS - A mass killing by firearm that consists of 3 or more killings in a single incident (H.R.2076 – 112th U.S. Congress (2011-2012): Investigative Assistance for Violent Crimes Act of 2012). HN - 2024 BX - Active Shooter Event BX - Mass Shooting BX - School Shooting BX - Shooting Spree FX - Wounds, Gunshot MH - Matrix Gla Protein UI - D000097568 MN - D12.776.157.125.444 MN - D12.776.860.300.716 MS - A 79-residue, vitamin K-dependent protein containing a single disulfide bond & 4.8 gamma-carboxyglutamate (Gla) residues. AN - Do not confuse with OSTEOCALCIN. HN - 2024 (1986) BX - Matrix gamma-Carboxyglutamic Acid Protein MH - Meat Substitutes UI - D000095866 MN - G7.203.300.631 MN - J2.500.631 MS - Bacterial, fungal, algal or plant-based alternatives to MEAT from animals. HN - 2024 BX - Meat Alternatives BX - Meat Analogs BX - Meat-Free Products BX - Plant-Based Meat Alternatives BX - Plant-Based Meat Analogs BX - Plant-Based Meat Substitutes BX - Simulated Meat BX - Vegan Meat MH - Medecins Sans Frontieres UI - D000095744 MN - N3.540.514.401 MN - N3.540.630.780.403 MS - An international humanitarian medical non-governmental organization of French origin that provides emergency aid and medical care around the globe. HN - 2024 BX - Doctors Without Borders BX - Médecins Sans Frontières MH - Media Exposure UI - D000097822 MN - F4.96.879.757.250 MN - I1.880.529 MN - L1.462.500.636 MS - The extent to which individuals encounter messages and content via COMMUNICATION MEDIA. HN - 2024 BX - Social Media Exposure MH - Medical Neglect UI - D000097824 MN - I1.198.240.540 MN - I1.880.735.191.127 MS - Failure to seek timely and appropriate care or allow such care for medical, dental or psychological needs by family members, legal guardian and other caregivers. Negligence by professionals is PROFESSIONAL NEGLIGENCE. HN - 2024 MH - Medicine, Thai Traditional UI - D000096262 MN - E2.190.488.769 MN - I1.76.201.450.654.762 MS - A system of traditional medicine which is based on the beliefs and practices of the Thai culture. HN - 2024 BX - Thai Massage BX - Thai Medicine BX - Thai Medicine Traditional BX - Thai Traditional Medicine BX - Traditional Medicine, Thai BX - Traditional Thai Massage MH - Melanogenesis UI - D000095868 MN - G2.111.545 MN - G3.474 MN - G4.536 MS - The biosynthesis of MELANINS in insects and higher animals. The key chemical step of melanogenesis is the initial conversion of TYROSINE to DOPAQUINONE by TYROSINASE, distinguishing melanogenesis from pathways for melanin synthesis in plants. Melanogenesis is complex process involving several stages from the formation of MELANOCYTES during EMBRYONIC DEVELOPMENT to the synthesis of MELANINS in the MELANOSOMES and their distribution via transport of the melanosomes to surrounding KERATINOCYTES. HN - 2024 BX - Eumelanogenesis BX - Phaeomelanogenesis MH - Melanoma, Cutaneous Malignant UI - D000096142 MN - C4.557.465.625.650.510.520 MN - C4.557.580.625.650.510.520 MN - C4.557.665.510.520 MN - C4.588.805.444 MN - C17.800.882.534 MS - A primary melanoma that originates from atypical skin MELANOCYTES, especially from acquired and congenital MELANOCYTIC NEVI, and DYSPLASTIC NEVI. HN - 2024 (2012) BX - Familial Atypical Mole-Malignant Melanoma Syndrome BX - FAMMM Syndrome MH - Mental Health Teletherapy UI - D000095882 MN - F4.408.674 MN - H2.403.840.300 MN - L1.462.500.847.652.275 MN - N2.421.461.472 MN - N4.590.374.800.275 MS - Providing mental health services via TELECOMMUNICATIONS. HN - 2024 BX - Telepsychology BX - Telepsychotherapy BX - Teletherapy, Mental Health FX - Distance Counseling MH - Metabolic Reprogramming UI - D000097784 MN - G3.295.484 MN - G4.152.262.500 MN - G5.135.500 MS - Various cellular responses cells undergo in order to sustain energy production under cellular METABOLIC STRESS. Oncogenic metabolic reprogramming is one of the hallmarks of cancer progression and metastasis. HN - 2024 BX - Metabolic Programming BX - Metabolism Programming BX - Metabolism Reprogramming MH - Micropeptides UI - D000096903 MN - D12.888 MS - Polypeptides 100 amino acids or less in length that are encoded by SHORT OPEN READING FRAME. HN - 2024(2023) BX - lncRNA-Encoded Micropeptides BX - Microproteins BX - Short ORF-Encoded Peptides BX - Small ORF-Encoded Micropeptides BX - Small ORF-Encoded Peptides BX - smORF-Encoded Micropeptides BX - smORF-Encoded Peptides BX - sORF-Encoded Micropeptides BX - sORF-Encoded Peptides MH - Mitochondria Associated Membranes UI - D000096322 MN - A11.284.149.450.349.500 MN - A11.284.430.214.190.875.248.655 MN - A11.284.835.514.349.500 MS - Specialized areas of the endoplasmic reticulum in close physical contact with MITOCHONDRIA. These inter-organelle contact sites participate in the regulation of various processes such as MITOCHONDRIAL DYNAMICS; CALCIUM SIGNALING; ENERGY METABOLISM and INFLAMMATION. HN - 2024 BX - Endoplasmic Reticulum Mitochondrial Contact Sites BX - Endoplasmic Reticulum-Mitochondria Contacts BX - ER Mitochondria Encounter Structure BX - ER Mitochondria Membrane Contact Sites BX - ERMCSs BX - ERMES Endoplasmic Reticulum Mitochondria Encounter Structure BX - MERCs Mitochondria-Endoplasmic Reticulum Contacts BX - MICOS BX - MINOS BX - Mitochondria Associated Endoplasmic Reticulum Membranes BX - Mitochondria-Associated ER Membranes BX - Mitochondria-Associated Membranes BX - Mitochondria-Endoplasmic Reticulum Contacts BX - Mitochondria-ER Contact Sites BX - Mitochondrial Associated Endoplasmic Reticulum Membranes BX - Mitochondrial Associated Membranes BX - Mitochondrial Contact Site BX - Mitochondrial Inner Membrane Organizing System BX - Mitochondrial Organizing Structure BX - MITOS MH - Mitochondrial Processing Peptidase UI - D000096122 MN - D8.811.277.656.300.480.563 MN - D8.811.277.656.675.374.563 MN - D12.776.575.758 MS - A hetero-dimeric protein consisting of two subunits, alpha and beta, which are referred to as PMPCA and PMPCB in humans. It plays an essential role in removing the N-terminal targeting peptidase from precursor proteins imported into the mitochondria. HN - 2024 (1990) BX - Matrix Processing Peptidase BX - Mitochondrial Processing Protease MH - Mitogen-Activated Protein Kinase Kinase Kinase 11 UI - D000097767 MN - D8.811.913.696.620.682.700.559.650 MN - D12.776.476.563.554.650 MS - A MAP kinase kinase kinase that activates the SAPK/JNK and p38/ERK SIGNAL TRANSDUCTION pathways. It has multiple interaction domains, including a Cdc42 binding motif. HN - 2024 (1997) BX - Mixed Lineage Kinase 3 BX - Mixed Lineage Kinase-3 MH - Mosquito-Borne Diseases UI - D000096724 MN - C1.920.852 MS - Infectious diseases transmitted by mosquito vectors. Mosquito-borne human viral diseases include Chikungunya, Dengue, viral encephalitis (e.g., Japanese and St. Louis types), West Nile, Yellow fever, Zika virus infections. Mosquito-borne human parasitic diseases include malaria and lymphatic filariasis. Equine encephalomyelitis and dirofilariasis are mosquito-borne viral diseases mostly in animals. HN - 2024(2023) BX - Aedes-Borne Diseases BX - Anopheles-Borne Diseases BX - Mosquito Borne Diseases BX - Mosquito-Borne Parasitic Diseases BX - Mosquito-Borne Viral Diseases MH - Myokines UI - D000097724 MN - D12.644.276.857 MN - D12.776.467.854 MN - D23.529.841 MS - Signaling proteins that are synthesized and released by muscle fibers in response to exercise or other forms of physical activity. HN - 2024 BX - Myokine MH - Myrmecophytes UI - D000097543 MN - B1.650.305 MS - Plants that host ANTS by providing shelter in specialized nesting structures or domatia (e.g., Beltian or Mullerian bodies) and sometimes provide food (e.g., food and pearl bodies; and EXTRAFLORAL NECTARS). Ant colony in turn provides the host plant with defense against encroaching foliage, nutrients via waste by-product and help with SEED DISPERSAL. HN - 2024 BX - Ant Plants BX - Ant-Plants BX - Myrmecophytic Ant-Plants BX - Myrmecophytic Plants MH - Nanovaccines UI - D000097007 MN - D20.215.894.468 MN - D26.255.260.750.500 MN - E2.319.300.380.800.500 MS - Vaccines that use NANOPARTICLES as carriers and IMMUNOLOGIC ADJUVANTS. HN - 2024 BX - Nano-Particle Vaccine BX - Nano-Vaccine BX - Nanoparticle Vaccine BX - Nanovaccine MH - Narcissistic Personality Disorder UI - D000097165 MN - F3.675.500 MS - A pattern of grandiosity, need for admiration, and lack of empathy. (ncbi.nlm.nih.gov/books/NBK556001/) HN - See Personality Disorders 1998-2023: 2024 BX - Malignant Narcissism BX - Pathological Narcissism MH - Neurexins UI - D000096784 MN - D9.400.430.890.200.250.640 MN - D12.776.395.550.200.250.640 MN - D12.776.543.550.200.250.760 MN - D12.776.631.609 MN - D23.50.301.350.250.760 MS - Presynaptic cell-adhesion molecules that bind postsynaptic NEUROLIGINS to form calcium-dependent trans-synaptic adhesions. Neurexins recruit synaptic scaffolding proteins via their PDZ DOMAINS. Distribution and interaction with neuroligins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neurexins are associated with cognitive diseases such AUTISM SPECTRUM DISORDER; SCHIZOPHRENIA and Pitt-Hopkins-like syndrome 2. HN - 2024 MH - Neuroanesthesia UI - D000097867 MN - E3.155.837 MS - Anesthesia methods that are used for neurologic medical procedures. HN - 2024 BX - Neurosurgical Anesthesia MH - Neuroligins UI - D000096785 MN - D9.400.430.890.200.250.520.894 MN - D12.776.395.550.200.250.520.894 MN - D12.776.543.550.200.250.520.894 MN - D12.776.631.641 MN - D23.50.301.350.250.520.894 MS - Postsynaptic cell-adhesion molecules that bind presynaptic NEUREXINS to form calcium-dependent trans-synaptic adhesions. Neuroligins recruit synaptic scaffolding proteins (e.g., PSD-95) via their PDZ DOMAIN. The distribution and interaction with neurexins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neuroligins or neurexins are associated with cognitive diseases such as AUTISM SPECTRUM DISORDER. HN - 2024 BX - Neuroligin MH - Neuroserpin UI - D000097522 MN - D12.644.861.488 MN - D12.776.872.488 MS - An inhibitory serpin that inhibits PLASMINOGEN ACTIVATORS (tPA) in the brain. HN - 2024 (1996) BX - Peptidase Inhibitor 12 BX - PI12 Protein BX - SERPINI1 Protein MH - NF-kappaB-Inducing Kinase UI - D000097782 MN - D8.811.913.696.620.682.700.579 MN - D12.776.476.563.579 MS - A protein serine-threonine kinase that catalyzes the activation of canonical and non-canonical NF-kappaB pathways. HN - 2024 (1994) BX - MAP3K14 Kinase BX - Mitogen-Activated Protein Kinase Kinase Kinase 14 BX - NF-kappa B Kinase BX - NF-kappa-B-Inducing Kinase (NIK) BX - NFkB Kinase BX - NIK Protein BX - Nuclear Factor kappa B Kinase MH - Nicotine Replacement Therapy UI - D000095488 MN - E2.319.597 MS - Replacing NICOTINE from TOBACCO with an alternate source in order to reduce the severity of tobacco withdrawal during TOBACCO USE CESSATION. HN - 2024 FX - Smoking Cessation FX - Tobacco Use Cessation FX - Tobacco Use Cessation Devices MH - Nociceptin UI - D000097629 MN - D12.644.400.575.640 MN - D12.776.631.650.575.640 MS - A pronociceptive peptide that acts as a specific endogenous agonist to the NOCICEPTIN RECEPTOR. HN - 2024 (1995) BX - N-OFQ Peptide BX - Nociceptin-Orphanin FQ BX - Orphanin FQ MH - Non-Erosive Reflux Disease UI - D000096663 MN - C6.405.117.119.500.484.750 MS - A type of gastroesophageal reflux disease with acid reflux-related symptoms, but that does not affect the integrity of the ESOPHAGEAL MUCOSA. HN - 2024 BX - NERD Non-Erosive Reflux Disease BX - Non Erosive Reflux Disease BX - Non-Erosive GERD MH - Non-Medical Prescribing UI - D000096402 MN - E2.319.307.406 MN - E2.637 MN - N2.421.668.778.875 MS - Prescribing by a healthcare professional other than a doctor or dentist. HN - 2024 BX - Non-Medical Prescribers BX - Supplementary Prescribing MH - Nucleolin UI - D000097796 MN - D12.776.157.725.448 MN - D12.776.660.691 MN - D12.776.664.962.450 MS - Phosphoprotein found in nucleoli, on the cell membrane, and in cytoplasm of all higher eukaryotes. They act as a receptor for some viruses, bacteria, and toxins. HN - 2024 (1986) BX - C23 Protein MH - Nudix Hydrolases UI - D000096964 MN - D8.811.277.40.600.600 MS - A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder. HN - 2024 BX - Nucleoside Diphosphates-Linked to Moiety-X Hydrolases BX - Nudix Hydrolase BX - Nudix Proteins MH - Olivary Degeneration UI - D000095747 MN - C10.574.672 MS - Degeneration of the OLIVARY NUCLEUS typically involving INFERIOR OLIVARY COMPLEX. It is associated with various syndromes and neurodegenerative disorders including hypertrophic olivary degeneration secondary to a Guillain-Mollaret triangle lesion. HN - 2024 BX - Hypertrophic Olivary Degeneration BX - Hypertrophic Olivary Nucleus Degeneration BX - Inferior Olivary Hypertrophy BX - Olivary Nucleus Degeneration FX - Olivopontocerebellar Atrophies MH - Open Waste Burning UI - D000095865 MN - N6.230.216.625 MN - N6.850.860.510.900.600.500.500 MS - Incineration of materials such as GARBAGE or HAZARDOUS WASTES as in an open-air fire such as in a fire pit, barrel, or outdoor fireplace where AIR POLLUTANTS are not captured or contained. HN - 2024 BX - Burn Pits BX - Open Burning FX - Persian Gulf Syndrome MH - Oppositional Defiant Disorder UI - D000096865 MN - F3.625.94.475 MS - A repetitive and persistent pattern of behavior that develops in childhood and is characterized as recurrent disobedient, overall negative or agitated mood, a quarrelsome attitude or being vengeful toward authority figures. Unlike in conduct disorder defiant behaviors in oppositional defiant disorders typically do not involve aggression, destruction, theft, or deceit. Oppositional defiant disorder, CONDUCT DISORDER and ATTENTION DEFICIT AND HYPERACTIVITY DISORDER sometimes co-occur. HN - 2024 MH - Oral Frenectomy UI - D000095782 MN - E4.545.225 MN - E6.645.225 MS - Surgical procedures to release or remove abnormally short or tightly attached frenum (e.g., LINGUAL FRENUM or LABIAL FRENUM) associated with a pathological condition (e.g., TONGUE TIE and lip tie). HN - 2024 BX - Labial Frenectomy BX - Lingual Frenectomy BX - Lip Tie Release BX - Oral Frenotomy BX - Oral Frenulectomy BX - Oral Frenuloplasty BX - Oral Frenumectomy BX - Tongue Tie Release FX - Breast Feeding MH - Overlapping Surgery UI - D000096584 MN - E4.582 MS - SURGICAL PROCEDURES performed on two or more patients that overlap in their start and finish times, but the critical portions or those activities which require the skill and expertise of the primary surgeon do not overlap. The primary surgeon initiates and participates in another operation when the surgeon has completed the critical portions of the first procedure and is no longer an essential participant in the final phase of the first operation. HN - 2024 BX - Concurrent Surgery BX - Simultaneous Surgery FX - General Surgery FX - Intraoperative Complications FX - Operating Rooms FX - Postoperative Complications FX - Surgeons MH - Pandemic Preparedness UI - D000096763 MN - N6.230.100.35.250 MN - N6.850.780.200.625 MS - Various plans outlined for the care of casualties and the maintenance of services in a PANDEMIC. Pandemic preparedness plan includes CAPACITY BUILDING in flexible infrastructure and SENTINEL SURVEILLANCE. HN - 2024 BX - COVID-19 Pandemic Preparedness BX - COVID-19 Preparedness BX - Epidemic Preparedness BX - Epidemic Response Plan BX - Pandemic Influenza Preparedness BX - Pandemic Response Plan MH - Paraptosis UI - D000097924 MN - G4.146.954.625 MS - A type of programmed cell death resembling NECROSIS, with mitochondrial and ENDOPLASMIC RETICULUM swelling and accumulation of CYTOPLASMIC VACUOLES. Distinctive morphological changes to the CELL NUCLEUS are absent. HN - 2024 BX - Caspase-Independent Programmed Cell Death MH - Parthenium hysterophorus UI - D000097762 MN - B1.875.800.575.912.250.100.519 MS - An annual species in the family ASTERACEA, genus Parthenium which sometimes is referred to as feverfew, not to be confused with the medicinal herb often cultivated in the garden, TANACETUM PARTHENIUM. Parthenium hysterophorus is an invasive allelopathic weed indigenous to the Caribbean, Central and South America and has similar rosette stage structures as COMMON RAGWEED. It contains sesquiterpene lactones including parthenin which is poisonous to grazing animals and allergenic and irritant, causing Parthenium dermatitis in humans. HN - 2024 BX - Ragweed Parthenium BX - Santa Maria Feverfew FX - Tanacetum parthenium MH - Pathologic Complete Response UI - D000095384 MN - C23.550.291.656.525 MN - E1.789.800.262 MN - N4.761.559.590.800.427 MN - N5.715.360.575.575.800.427 MS - The disappearance of all signs of a disease upon REMISSION INDUCTION as supported by pathological examination. HN - 2024 BX - In Complete Remission BX - In Full Remission MH - Patient-Ventilator Asynchrony UI - D000097742 MN - C8.618.846.644 MN - C23.888.852.770 MS - A time mismatch between patient's inspiratory effort and MECHANICAL VENTILATOR's inspiratory time. HN - 2024 BX - Patient-Ventilator Asynchronies BX - Patient-Ventilator Dyssynchronies BX - Patient-Ventilator Dyssynchrony MH - Pediatric Anesthesia UI - D000097872 MN - E3.155.422 MS - Conducting anesthesia procedures in infants, children, and adolescents. HN - 2024 BX - Anesthesia, Pediatric MH - Peptidyl-Prolyl Isomerase D UI - D000097322 MN - D8.811.399.325.500.400.300.813 MN - D12.776.543.750.705.400.350.813 MN - D12.776.827.344.300.813 MS - A cytoplasmic cyclophilin with molecular chaperoning properties. It is found along with other MOLECULAR CHAPERONES, in steroid aporeceptor complexes and plays a role in maintaining the nonnative folding-competent intermediate state of the steroid aporeceptors. The protein has the alias name cyclophilin D which is also the alias name for the related protein Peptidyl-Prolyl Isomerase F. HN - 2024; use PEPTIDYL-PROLYL ISOMERASE F 2020-2023 BX - Cyclophilin 40 BX - Cyclophilin D, PPID BX - Cyclophilin-40 BX - CyP40 BX - PPIase D MH - Percutaneous Collagen Induction UI - D000097244 MN - E2.190.728 MN - E2.779.950 MN - E2.800.554 MN - E2.831.535.950 MS - An alternative treatment for skin dysfunctions that stimulates COLLAGEN production by encouraging normal WOUND HEALING that occurs after any trauma by inducing microlesions. HN - 2024 BX - Microneedling BX - Needling BX - Skin Needling MH - Periostin UI - D000096562 MN - D12.776.860.300.773 MS - A multifunctional extracellular matrix protein that modulates CELL ADHESION to induce attachment to the EXTRACELLULAR MATRIX and CELL MIGRATION. It has a role INFLAMMATION and NEOPLASM METASTASIS HN - 2024 BX - POSTN Protein MH - Peroxidasin UI - D000097423 MN - D8.811.682.732.700.500 MN - D12.776.860.300.779 MS - A peroxidase originally isolated from DROSOPHILA that catalyzes the oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate. Its functions include a role in EXTRACELLULAR MATRIX assembly of COLLAGEN TYPE IV; LAMININ; and FIBRONECTIN. HN - 2024 (1994) BX - Peroxidasins MH - Phase Separation UI - D000095496 MN - G1.618 MS - Processes by which homogeneous mixtures of immiscible components (solids, liquids, or gases) separate into distinct phases. HN - 2024 MH - Photomechanical Print UI - D000095463 MN - V2.697.500 MS - Printed image made using photographic images. HN - 2024 MH - Physician Engagement UI - D000096002 MN - I3.946.562.500 MN - N4.452.677.896.500 MN - N4.590.374.434 MN - N5.300.568 MS - A strategy to create more positive, stable relationships between health care organizations and physicians. The goal is to increase efficiency and productivity, improve PATIENT CARE and safety, create higher physician satisfaction and retention, and reduce operational costs. HN - 2024 BX - Physician Satisfaction FX - Attitude of Health Personnel FX - Burnout, Professional MH - Pleuromutilins UI - D000097567 MN - D2.455.849.291.564 MS - A tricyclic diterpene natural product isolated from Pleurotus mutilus (now referred to as Clitopilus scyphoides). Possesses modest antibacterial activity against primarily gram-positive bacterial organisms. HN - 2024 (1973) BX - Octahydro-5,8-dihydroxy-4,6,9,10- tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopenta- cycloocten-1(4H)-one 8-glycolate BX - Pleuromutilin BX - Pleuromutilin Antibiotics MH - Poison Frogs UI - D000097702 MN - B1.50.150.900.90.180.659 MS - Frogs that sequester and secrete POISONS (e.g., BATRACHOTOXINS). Poison frogs include Australian Pseudophryne, Central and South American Dendrobates, Epipedobates, and Phyllobates and Madagascan Mantella. Melanophyrniscus is a poison toad in the family of Bufonidae. All poison dart frogs are from rain forest of western Colombia and are members of Phyllobates. HN - 2024 BX - Dart Frogs BX - Poison Dart Frogs BX - Poison Toads BX - Venomous Frogs MH - Polo-Like Kinase 1 UI - D000097869 MN - D8.811.913.696.620.682.700.616.500 MN - D12.776.476.563.616.500 MS - Plays a crucial role in the regulation of proliferative activity of normal and malignant cells. Proposed as a new target for antineoplastic treatment strategies. HN - 2024 MH - Polo-like Kinases UI - D000097868 MN - D8.811.913.696.620.682.700.616 MN - D12.776.167.469 MN - D12.776.476.563.616 MS - Protein serine-threonine kinases which regulate entry into M phase, spindle pole biogenesis and function, mitotic chromosome dynamics, mitotic exit, and cytokinesis. They contain a characteristic Polo-box protein interaction domain. HN - 2024 MH - Polyamine Oxidase UI - D000097667 MN - D8.811.682.662.611 MS - An FAD-dependent enzyme in the polyamine catabolism pathway that generates hydrogen peroxide. Present with high activity in most tissues of vertebrate organisms. HN - 2024 (1977) BX - Aminoacetone Oxidase BX - N(1)-acetylpolyamine Oxidase BX - Non-Specific Polyamine Oxidase BX - Polyamine Oxidase (Propane-1,3-diamine-forming) BX - Spermidine Oxidase BX - Spermine Oxidase MH - Polyether Polyketides UI - D000095662 MN - D2.355.291.933 MN - D2.540.576.625 MN - D4.345.241.654 MN - D4.345.674.625 MS - Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins. HN - 2024 BX - Marine Ladder Polyethers BX - Polyether Antibiotics BX - Polyether Ionophore Antibiotics BX - Polyether Ionophores MH - Polyether Toxins UI - D000095702 MN - D2.355.291.933.875 MN - D2.540.576.625.937 MN - D4.345.241.654.937 MN - D4.345.674.625.937 MN - D23.946.580.800 MS - Polycyclic polyether polyketides most often produced by marine organisms, e.g., DINOFLAGELLATES. Many polyether marine toxins are ionophores and neurotoxins and responsible for seafood poisoning. HN - 2024 BX - Marine Polyether Toxins MH - Polypeptide N-acetylgalactosaminyltransferase UI - D000097763 MN - D8.811.913.400.100.200.650 MS - Family of enzymes that catalyze the formation of GalNAcAlpha1-serine/threonine linkages in glycoproteins. HN - 2024 (1970) BX - Galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase BX - Globoside beta GalNAc Transferase BX - Globoside Synthase BX - Protein-UDPacetylgalactosaminyltransferase MH - Post-Exercise Recovery UI - D000096062 MN - G7.25.566 MN - G11.427.410.698.277.421 MN - G16.12.500.767 MN - I3.350.421 MS - The subsequent return to a resting or recovered state following a bout of exercise as the body adapts to the stress associated with exercise, replenishes muscle glycogen, and repairs body tissue. HN - 2024 BX - Post-Workout Recovery BX - Recovery From Exercise FX - Rest MH - Post-Exercise Recovery Techniques UI - D000096063 MN - E2.779.966 MN - E2.831.535.966 MS - Therapeutic modalities following a bout of exercise to reduce markers of muscle damage, soreness, fatigue, and inflammation. HN - 2024 MH - Postdoctoral Training UI - D000096783 MN - I2.358.337.125.500 MS - Training for terminal degree holders in biological and biomedical science specialties who have already obtained a doctoral degree. HN - 2024 BX - Postdoctoral Fellows Training MH - Postmortem Imaging UI - D000097873 MN - E1.370.60.500 MN - E1.370.350.650 MN - E5.70.500 MN - I1.198.780.937.120.500 MS - The generation of images of the body's structures, organs, and tissues after death. HN - 2024 BX - Post-Mortem Computed Tomography BX - Post-Mortem Computed Tomography Imaging BX - Post-Mortem CT BX - Post-Mortem CT Imaging BX - Post-Mortem Imaging BX - Post-Mortem Magnetic Resonance Imaging BX - Post-Mortem MRI BX - Post-Mortem Radiological Imaging BX - Postmortem Computed Tomography BX - Postmortem Computed Tomography Imaging BX - Postmortem CT BX - Postmortem CT Imaging BX - Postmortem Magnetic Resonance Imaging BX - Postmortem MRI BX - Postmortem Radiological Imaging FX - Forensic Imaging MH - Power Plant Operators UI - D000096246 MN - M1.526.780 MS - Operators of industrial equipment to generate electrical power. HN - 2024 BX - Coal-fired Power Plant Workers BX - Nuclear Power Plant Operators BX - Nuclear Power Plant Workers BX - Nuclear Power Workers BX - Power Plant Workers MH - Pradimicins and Benanomicins UI - D000095643 MN - D2.455.426.559.847.562.50.825 MN - D2.540.576.750 MN - D2.806.550.469 MN - D4.345.674.750 MN - D4.615.562.50.825 MN - D9.408.51.59.825 MS - Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria, e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g., D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins and benanomicins have anti-HIV activities. HN - 2024 BX - Benanomicin and Pradimicin Antibiotics BX - Benanomicin Antibiotics BX - Benanomicinones BX - Benanomicins BX - Benanomicins and Pradimicins BX - Pradimicin and Benanomicin Antibiotics BX - Pradimicin Antibiotics BX - Pradimicin-Like Polyketides BX - Pradimicin-Type Polyphenols BX - Pradimicinones BX - Pradimicins MH - Pre-Registration Publication UI - D000095962 MN - L1.737.640.500 MS - Editorial decisions based on rigorous evaluation of submitted research question and methodology but before the research is conducted and a final submission is available. HN - 2024 BX - Frontloading Editorial Selection BX - Registered Reports MH - Propionyl-Coenzyme A Carboxylase UI - D000095562 MN - D8.811.464.257.50.500 MS - Mitochondrial carboxylase that is involved in the catabolism of odd chain fatty acids and branched amino acids. Dysfunction of propionyl-CoA carboxylase leads to the inherited metabolic disorder PROPIONIC ACIDEMIA. In bacteria it is an ATP-dependent carboxylase in CO2 fixation reactions where propionyl-CoA is converted to (S)-methylmalonyl-CoA. HN - 2024; use Methylmalonyl-CoA Decarboxylase 2004-2023 BX - Propionyl-CoA Carboxylase MH - Protein Phosphatase Inhibitory Proteins UI - D000097847 MN - D12.644.360.606 MN - D12.776.476.561 MS - A group of proteins that control the activity of PROTEIN PHOSPHATASES. HN - 2024 BX - Protein Phosphatase Inhibitor Proteins MH - Protein Subunit Vaccines UI - D000096202 MN - D20.215.894.860.900.633 MS - Vaccines that contain polypeptide chains, which are derived from specific pathogen's protein subunits. HN - 2024 BX - Peptide Vaccine BX - Peptide Vaccines BX - Recombinant Protein Subunit Vaccines BX - Recombinant Protein Vaccines BX - Vaccines, Peptide BX - Vaccines, Subunit, Protein MH - ProTides UI - D000095802 MN - D13.695.623 MN - D26.675.500 MS - A class of prodrugs consisting of a 5'-nucleoside monophosphate in which the two hydroxyl groups are masked with an amino acid ester and an aryloxy component which once in the cell is enzymatically metabolized to deliver free 5'-monophosphate, and further transformed to the active 5'-triphosphate form of the nucleoside analogue. HN - 2024 BX - Pro-Tide BX - Pro-Tides BX - Prodrug Nucleotide BX - Prodrug Nucleotides BX - ProTide MH - Pseudomonas aeruginosa Exotoxin A UI - D000097668 MN - D8.811.913.400.725.115.826 MN - D23.946.123.574 MN - D23.946.350.625 MN - D23.946.896.245 MS - An NAD-dependent ADP-ribosyltransferase that catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD onto elongation factor 2 (EF-2) thus arresting protein synthesis. Commonly used as the toxin in immunotoxins. HN - 2024 (2022) BX - Exotoxin A, Pseudomonas BX - Exotoxin A, Pseudomonas aeruginosa BX - Recombinant Truncated Pseudomonas Exotoxin A, Form PE38QQR BX - Recombinant Truncated Pseudomonas Exotoxin A, Form PE40 BX - ToxA protein, Pseudomonas aeruginosa MH - Psychiatrists UI - D000096244 MN - M1.526.485.810.843 MN - N2.360.810.843 MS - Qualified medical professionals specializing in maintaining MENTAL HEALTH and treating MENTAL DISORDERS. HN - 2024 BX - Psychiatrist MH - Psychological Growth UI - D000097812 MN - F1.58.736 MS - A process of actively learning and adapting to new ways to function following a challenging life crisis. HN - 2024 BX - Growth Opportunities BX - Mental Growth BX - Stress-Related Growth MH - Psychological Safety UI - D000095422 MN - F1.829.612 MN - F4.96.628.829.500 MS - An environment where people are able to act and engage without fear of punishment or humiliation from others. HN - 2024 MH - Puberty Inhibitors UI - D000097770 MN - D6.347.855 MN - D27.505.696.399.450.783 MS - Agents that are used to temporarily suppress puberty in adolescents. HN - 2024 BX - Pubertal Blockers BX - Puberty Blockers MH - Puberty Suppression UI - D000097765 MN - E2.906.250 MN - N4.590.374.268.250 MN - N5.300.361.250 MS - A non-intensive, reversible medical intervention achieved by using compounds that mimic the actions of GONADOTROPIN-RELEASING HORMONE (GnRH), which in turn slows or stops the physical changes associated with puberty such as the development of breasts or facial hair. HN - 2024 BX - Puberty Blocking MH - Public Health Infrastructure UI - D000096102 MN - N2.814 MS - Systems built on capacity of workforce, information systems, organizational resources and include public health programs, policies and resources that enable public health agencies to perform their core functions and essential services. HN - 2024 BX - Health Care Infrastructure BX - Health Infrastructure BX - Healthcare Infrastructure BX - Public Health Infrastructures FX - Health Resources MH - Quantitative Phase Imaging UI - D000097913 MN - E1.370.350.515.513.784 MN - E5.595.513.784 MS - Contrast imaging generated from the measurements of phase shift changes of light waves as they pass through transparent objects of varying thickness and refractivity. HN - 2024 BX - Digital Holographic Microscopy BX - Digital Holography BX - Holographic Microscopy BX - Microscopy, Quantitative Phase Contrast BX - Quantitative Phase Contrast Microscopy BX - Quantitative Phase Microscopy MH - Rabphilin-3A UI - D000097624 MN - D12.644.360.24.322 MN - D12.776.157.57.150 MN - D12.776.476.24.409 MN - D12.776.543.990.12 MN - D12.776.631.656 MS - A putative target protein for RAB3A GTP-BINDING PROTEIN. Implicated in regulated secretion, particularly in neurotransmitter release. HN - 2024 (1993) MH - RAC2 GTP-Binding Protein UI - D000097766 MN - D8.811.277.40.330.300.400.700.100.750 MN - D12.776.157.325.515.700.100.550 MN - D12.776.476.338.400.700.100.750 MS - A small rac GTP-binding protein that forms one of the components of the NADPH oxidase enzyme system. HN - 2024 (1991) MH - Radiomics UI - D000097188 MN - E1.370.350.705 MS - Extraction of a large number of features from patient images using data characterization algorithms to uncover tumoral patterns and characteristics that improve diagnosis. HN - 2024 MH - Ramucirumab UI - D000096662 MN - D12.776.124.486.485.114.224.60.866 MN - D12.776.124.790.651.114.224.60.866 MN - D12.776.377.715.548.114.224.200.866 MS - A humanized monoclonal antibody and antagonist of VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 (VEGFR2). HN - 2024 (2009) MH - Receptor, Serotonin, 5-HT1F UI - D000096642 MN - D12.776.543.750.670.800.100.600 MN - D12.776.543.750.695.800.100.600 MN - D12.776.543.750.720.850.100.600 MS - A serotonin receptor subtype found in the GLOBUS PALLIDUS; HIPPOCAMPUS; PUTAMEN; SUBSTANTIA NIGRA; and TRIGEMINAL NUCLEUS, SPINAL that can modulate the release of CALCITONIN GENE-RELATED PEPTIDE from these nerves. Unlike 5-HT1B RECEPTORS, the activation of 5-HT1F receptors does not cause VASOCONSTRICTION. 5-HT1F receptor antagonists are used for the treatment of MIGRAINE. HN - 2024 (1997) BX - 5-HT(1F) Receptor BX - 5-HT1F Receptor BX - Receptor, Serotonin 1F BX - Receptors, Serotonin 5-HT1F BX - Serotonin 1F Receptor BX - Serotonin 1F Receptors MH - Red Fluorescent Protein UI - D000097573 MN - D12.776.532.755 MS - Protein analogs and derivatives of the Disocosoma red fluorescent protein that emit a red-orange light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used as REPORTER GENES and FLUORESCENT PROBES for MICROSCOPY of living cells and organisms. HN - 2024 (2000) MH - Red Light UI - D000095742 MN - G1.358.500.505.650.809 MN - G1.590.540.837 MN - G1.750.250.650.809 MN - G1.750.770.578.809 MS - That portion of the electromagnetic spectrum with wavelengths between 620 to 750 nm. Red light is used therapeutically to improve the appearance of SKIN by reducing wrinkles, scars, redness, and ACNE. It is often used in conjunction with PHOTOSENSITIZING AGENTS for PHOTOCHEMOTHERAPY. HN - 2024 FX - Low-Level Light Therapy FX - Photochemotherapy MH - Retinoic Acid Receptor gamma UI - D000097768 MN - D12.776.826.701.375 MN - D12.776.930.775.375 MS - A retinoic acid receptor that regulates transcriptional activity by heterodimerizing with nuclear RETINOID X RECEPTORS. HN - 2024 (1993) MH - Retrograde Ejaculation UI - D000097908 MN - C12.100.500.150.750 MN - C12.100.875.364.750 MN - C12.200.294.150.750 MS - The flow of SEMINAL FLUID, from the posterior URETHRA, backwards into the BLADDER. Causes include injuries such as from SPINAL CORD INJURIES; DIABETIC NEUROPATHIES; surgeries in adjacent tissues such as AORTIC ANEURYSM surgeries and transurethral bladder neck incisions; or drug side effects. HN - 2024 MH - Rhinosinusitis UI - D000096825 MN - C1.748.674.500 MN - C1.748.749.703 MN - C8.460.692.752.703 MN - C8.460.799.955 MN - C8.730.674.500 MN - C8.730.749.703 MN - C9.603.692.752.703 MN - C9.603.799.955 MS - Obstruction of sinus drainage into the NASAL CAVITY and inflammation of the NASAL MUCOSA in the PARANASAL SINUSES. HN - 2024 BX - Rhino-sinusitis MH - RNA Methylation UI - D000097906 MN - G2.111.35.538.580 MN - G2.111.760.475 MN - G2.607.94.538.500 MN - G3.59.538.580 MN - G3.839.475 MN - G5.308.700.475 MS - The addition of a methyl group to one of the NITROGEN atoms on a NUCLEOTIDE base in an RNA molecule. HN - 2024 BX - m1A RNA Methylation BX - m3G RNA Methylation BX - m5C RNA Methylation BX - m6A Methylation of RNA BX - m6A Methylation, RNA BX - m6A Modification of RNA BX - m6A RNA Methylation BX - m6A RNA Modification BX - m7G RNA Methylation BX - N6-Methyladenosine RNA Methylation MH - RNA, Competitive Endogenous UI - D000095482 MN - D13.444.735.477 MS - Coding or noncoding RNAs which regulate the expression of other RNA transcripts by competing for shared MICRORNAS. HN - 2024 BX - ceRNA BX - Competing Endogenous RNA BX - Competitive Endogenous RNA MH - Role Conflict UI - D000097823 MN - F1.658.209.500 MS - A state of tension or distress that occurs when fulfilling roles of one status making it difficult to fulfill the roles of another. HN - 2024 BX - Inter-Role Conflict BX - Inter-Sender Conflict BX - Interrole Conflict BX - Intersender Conflict BX - Intra-Role Conflict BX - Intra-Sender Conflict BX - Intrarole Conflict BX - Intrasender Conflict BX - Role Strain MH - Rosmarinic Acid UI - D000097123 MN - D2.241.223.100.300.100.500 MN - D2.241.223.200.690 MN - D2.241.511.390.100.500 MN - D2.455.426.559.389.127.281.100.500 MN - D2.455.426.559.389.657.410.100.500 MS - A polyphenol compound that naturally occurs in rosemary with ANTIOXIDANT and anti-inflammatory properties.  HN - 2024 (1984) BX - Rosemary Acid BX - Rosmarinate BX - Rosmarinic Acid, (R-(E))-Isomer MH - Ross River Virus Infection UI - D000096745 MN - C1.920.313.78.685 MN - C1.920.852.32.685 MN - C1.925.81.895 MN - C1.925.782.930.100.685 MS - Virus diseases caused by Ross River virus of the ALPHAVIRUS genus. It is the most common endemic arboviral infection in Australia. HN - 2024(2020) BX - Ross River Virus Disease MH - Roundabout Proteins UI - D000097905 MN - D12.776.543.750.916 MS - A family of single-pass transmembrane receptors that act as the cognate receptors for the secreted guidance factor Slit emanating from central nervous system midlines. HN - 2024 (2004) BX - Robo Proteins BX - Robo-1 Protein BX - Robo1 Protein BX - Roundabout 1 Protein MH - Second Generation Cephalosporins UI - D000097909 MN - D27.505.954.122.85.386.750 MS - Agents with less activity against gram-positive cocci than FIRST GENERATION CEPHALOSPORINS but have increased activity against gram-negative bacilli. HN - 2024 BX - Second Generation Cephalosporin BX - Second-Generation Cephalosporins MH - Secreted Aspartic Proteases UI - D000097790 MN - D8.811.277.656.74.500.890 MS - Enzymes that are produced and secreted by organisms, including bacterial and fungi.They are involved in a variety of biological processes, such as nutrient acquisition, pathogenesis of candida, and host tissue invasion. HN - 2024 BX - Secreted Aspartyl Proteases MH - Sigma-1 Receptor UI - D000097605 MN - D12.776.543.750.695.620.775.500 MN - D12.776.543.750.720.600.610.775.500 MN - D12.776.543.750.750.555.610.775.500 MS - A sigma receptor that regulates neuroinflammation, neurotransmitters, neurogenesis, ENDOPLASMIC RETICULUM stress and MITOCHONDRIA function. HN - 2024 (1997) BX - Receptor 1, Sigma MH - Social Genomics UI - D000097826 MN - H1.158.273.180.350.962 MN - H1.158.273.343.350.850 MS - Field of genetics studying correlates between variations in SOCIOLOGICAL FACTORS and differences in GENOME-wide GENE EXPRESSION REGULATION. HN - 2024 BX - Sociogenomics MH - Soft Computing UI - D000097786 MN - L1.224.850 MS - Computing that deals with approximate models and gives solutions to complex real-life problems. Has greater tolerance for imprecision, uncertainty, partial truth, and approximations. Based on techniques such as FUZZY LOGIC, genetic algorithms, NEURAL NETWORKS, COMPUTER, MACHINE LEARNING, and EXPERT SYSTEMS. HN - 2024 MH - Solute Carrier Family 12 UI - D000096925 MN - D12.776.157.530.450.250.910 MN - D12.776.157.530.450.625.875 MN - D12.776.543.585.450.250.918 MN - D12.776.543.585.450.625.875 MS - Inorganic cation-chloride cotransporters mediating the movement of inorganic SODIUM and/or POTASSIUM cations, coupled to the movement of CHLORIDE anions. The solute carrier 12 (SLC12) family can be divided into Na+-dependent SLC12A1-A3 (NKCC1, NKCC2, and NCC) and Na+-independent SLC12A4-A7 (KCC1-KCC4). HN - 2024 MH - Solute Carrier Family 44, Member 2 Protein UI - D000097871 MN - D12.776.157.530.937.828 MN - D12.776.543.585.475.719 MN - D12.776.543.585.937.926 MN - D12.776.575.750.719 MS - A mitochondrion and plasma membrane protein that enables choline transmembrane transporter activity. HN - 2024 BX - Choline Transporter-Like Protein 2 BX - SLC44A2 Protein MH - Spirooxindoles UI - D000096563 MN - D2.455.426.779.900 MN - D3.132.436.511.500 MN - D3.633.100.473.402.528.500 MN - D3.633.100.496.500.500.511.500 MN - D4.711.900 MS - Compounds that consist of cycloalkyl or heterocyclic moieties fused at the C-3 position of an oxindole. Their applications include use as scaffolds in drug design processes. HN - 2024 BX - Spiro-Oxindoles MH - SS-B Antigen UI - D000097585 MN - D12.776.157.725.500.914 MN - D12.776.664.962.500.914 MN - D23.50.422.875 MS - Nuclear autoantigens implicated in nascent RNA protection. It is a target of AUTOANTIBODIES in patients with SJOGREN'S SYNDROME. HN - 2024 (1982) BX - LA Antigen BX - La(SSB) Antigen BX - Lupus Antigen La BX - Sjogren's Syndrome-B Antigen BX - SS-B La Antigen MH - Stemona Alkaloids UI - D000097843 MN - D3.132.795 MS - Structurally related ALKALOIDS derived from the plants of the monocotyledonous family STEMONACEAE, characterized by the presence of a pyrrolo(1,2-a)azepine or a pyrido(1,2-a)azepine nucleus. HN - 2024 BX - Stemonaceae Alkaloids MH - Sterilizing Immunity UI - D000096064 MN - G12.450.850 MS - A type of immunity involving NEUTRALIZING ANTIBODIES that completely prevents a disease-causing pathogen from establishing an infection, including ASYMTOMATIC INFECTIONS. HN - 2024 MH - Sterol O-Acyltransferase 2 UI - D000097587 MN - D8.811.913.50.799.500 MS - A sterol O-acyltransferase that catalyzes reaction of Acyl-CoA and cholesterol into CoA and cholesterol ester. It is a distinct enzyme from Acetyl-CoA C-Acetyltransferase 2, which is also referred to as ACAT2. HN - 2024 (2001) BX - Acyl-CoA Cholesterol Acyltransferase-2 BX - Acyl-Coenzyme A:Cholesterol Acyltransferase 2 (ACAT-2) BX - Acyl-Coenzyme A:Cholesterol Acyltransferase 2 (ACAT2) BX - SOAT-2 Protein BX - SOAT2 Protein MH - Subjective Stress UI - D000097844 MN - F1.145.126.990.867 MN - F2.830.900.833 MS - Perceptions of PSYCHOLOGICAL STRESS based on the individual's own personal values, beliefs and past and current experiences and circumstances. HN - 2024 MH - Super Enhancers UI - D000095483 MN - G2.111.570.80.689.330.850 MN - G5.360.80.689.330.850 MN - G5.360.340.24.340.137.750.249.882 MS - Large clusters of transcriptional enhancers which drive expression of genes that define cell identity. HN - 2024 BX - Superenhancers MH - Symptom Burden UI - D000096042 MN - E5.318.308.980.438.475.456.750 MN - N5.715.360.300.800.438.375.364.750 MN - N6.850.520.308.980.438.475.364.750 MS - The subjective, quantifiable prevalence, frequency, and severity of symptoms placing a physiologic burden on patients and producing multiple negative, physical, and emotional patient responses. HN - 2024 FX - Severity of Illness Index FX - Sickness Impact Profile MH - T-Cell Senescence UI - D000095843 MN - G4.43.538 MN - G7.345.124.390.500 MN - G12.460.500.500 MS - Permanent G1 CELL CYCLE ARREST of the T-cell, resulting from ageing, oncogene activation, telomere degradation, epigenomic changes, or exposure to stressful stimuli including reactive-oxygen species, ionizing radiation, or certain chemicals. HN - 2024 BX - T-Cell Ageing BX - T-Cell Aging BX - T-Lymphocyte Aging BX - T-Lymphocyte Senescence FX - T-Cell Exhaustion MH - Task Shifting UI - D000096286 MN - I3.946.506 MS - The rational redistribution of tasks among health workforce teams. World Health Organization. https://apps.who.int/iris/handle/10665/43821. HN - 2024 MH - Third Generation Cephalosporins UI - D000097911 MN - D27.505.954.122.85.386.875 MS - Agents that are structurally similar to other CEPHALOSPORINS but have a broader spectrum of activity against bacteria than the first and second generation cephalosporins. These agents cover more resistant STREPTOCOCCUS, STAPHYLOCOCCUS, gram-positive anaerobes, and more resistant strains of HAEMOPHILUS, NEISSERIA, PROTEUS, ESCHERICHIA COLI, and KLEBSIELLA (HNPEK). HN - 2024 BX - Third Generation Cephalosporin MH - Thyroid Hormone-Binding Proteins UI - D000097810 MN - D12.776.157.774 MN - D12.776.543.935 MS - Membrane-bound proteins found in the ENDOPLASMIC RETICULUM of CULTURED CELLS and NEOPLASMS. They were identified originally based on their capacity to bind THYROID HORMONE. AN - Do not confuse with C-TERMINAL BINDING PROTEIN. HN - 2024 (1987) BX - 3,5,3'-triiodothyronine-Binding Protein BX - Cytosolic Thyroid Hormone-Binding Protein BX - Pyruvate Kinase Muscle Isozyme BX - Pyruvate Kinase, M1 Isozyme BX - T3-Binding Protein p55 BX - T4-Binding Protein p55 BX - Thyroid Hormone-Binding Protein BX - Thyroid Hormone-Binding Protein p55 BX - Thyroid Hormone-Binding Protein p58 BX - Triiodothyronine-Binding Protein p55 MH - Tibiofemoral Joint UI - D000097547 MN - A2.835.583.475.825 MS - The articulation between the articular surfaces of the TIBIA and the FEMUR. HN - 2024 BX - Tibiofemoral Articulation BX - Tibiofemoral Contact BX - Tibiofibular Articulation BX - Tibiofibular Joint MH - Time Pressure UI - D000098002 MN - F1.145.126.990.933 MN - F2.830.900.916 MS - Sense of time urgency to complete a task. This sense of time urgency creates psychological pressure affecting performance (https://www.nrc.gov/docs/ML2112/ML21127A272.pdf). HN - 2024 BX - Deadline Pressure BX - Time Constraint MH - Tissue Inhibitor of Metalloproteinase-4 UI - D000097792 MN - D12.776.815.875.775 MS - An inhibitor of matrix metalloproteinases involved in regulation of PLATELET AGGREGATION and recruitment. HN - 2024 BX - Tissue Inhibitor of Metalloproteinase 4 MH - Toll-Like Receptor Agonists UI - D000097912 MN - D27.505.519.952 MN - D27.505.696.477.396.500 MS - Agents that stimulate TOLL-LIKE RECEPTOR signaling, and the activity of both the INNATE IMMUNE RESPONSE and ADAPTIVE IMMUNITY. HN - 2024 BX - TLR Agonists BX - Toll-Like Receptor Agonist MH - Trace Amine-Associated Receptors UI - D000095383 MN - D12.776.543.750.695.600.500 MS - G-protein coupled receptors that interact with trace amine compounds (e.g., P-OCTOPAMINE; BETA-PHENYLETHYLALMINE; TRYPTAMINE; P-TYRAMINE) which are present at low tissue levels in mammals. Most human trace amine-associated receptors are expressed in olfactory epithelium neurons. HN - 2024 BX - TAARs Trace Amine-Associated Receptors BX - Trace Amine Associated Receptor FX - Receptors, Biogenic Amine MH - Transcription Factor MTF-1 UI - D000097809 MN - D12.776.260.768 MN - D12.776.930.919 MS - A zinc dependent transcription factor involved in the regulation of intracellular signaling pathways. Regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. HN - 2024 (1993) BX - Metal-Responsive Transcription Factor-1 BX - MRE-Binding Transcription Factor MH - Translesion DNA Synthesis UI - D000096963 MN - G2.111.225.380.500 MN - G5.226.380.500 MS - DNA damage tolerant, error-prone DNA replication by specialized DNA POLYMERASES that can accommodate damaged bases in their active sites and insert NUCLEOTIDES in the strand directly opposite the DNA DAMAGE. HN - 2024 BX - Trans-Lesion DNA Replication BX - Trans-Lesion DNA Synthesis BX - Trans-Lesion Synthesis BX - Trans-Lesional DNA Replication BX - Trans-Lesional DNA Synthesis BX - Translesion DNA Replication BX - Translesion Synthesis BX - Translesion Synthesis Pathway BX - Translesional DNA Synthesis BX - Translesional Synthesis BX - Translesional Synthesis Pathway MH - Treatment Delay UI - D000096182 MN - E2.760.928.500 MN - N2.421.585.928.500 MS - A longer or slower than expected, or desired, amount of time between onset of symptoms and initiation of therapy. HN - 2024; use TIME-TO-TREATMENT 2019-2023 BX - Delayed Treatment FX - Time-to-Treatment MH - Treatment Effect Heterogeneity UI - D000096962 MN - N5.715.360.575.575.800.737 MS - The varying of responses to a given intervention or treatment that occurs across patients or patient subgroups. HN - 2024 BX - Heterogeneity in Treatment Effects BX - Heterogeneity of Treatment Effects BX - Heterogeneous Treatment Effects MH - Treatment Interruption UI - D000097042 MN - N5.300.150.800.688 MS - A deliberate decision between the patient and health care provider to stop medication for a defined period of time and for a specific clinical purpose. HN - 2024 BX - Drug Holiday BX - Interrupted Treatment BX - Medication Holiday BX - Planned Treatment Interruption BX - Scheduled Treatment Interruption BX - Structured Treatment Interruption MH - Truck Drivers UI - D000095402 MN - M1.526.959 MS - Persons skilled or qualified to operate trucks. HN - 2024 MH - Tuft Cells UI - D000095491 MN - A8.675.650.915.500.900 MN - A8.800.950.500.900 MN - A11.436.940 MN - A11.671.650.915.500.900 MS - Epithelial chemosensory cells with apical microvilli. They are found in many different organs and they share characteristics with the chemosensory cells in taste buds. These cells can be activated by infections in the gastrointestinal tract. HN - 2024 BX - Brush Cells BX - Caveolated Cells MH - Two-Pore Channels UI - D000097903 MN - D12.776.157.530.400.950 MN - D12.776.543.550.450.937 MN - D12.776.543.585.400.950 MS - Ligand-gated cation-selective ION CHANNELS located in ENDOSOMES and LYSOSOMES of plant and animal cells. HN - 2024 BX - Two-Pore Channel MH - UDP Xylose-Protein Xylosyltransferase UI - D000097608 MN - D8.811.913.400.725.925 MS - A pentosyltransferase that initiates a series of post-translational modifications necessary for transport and secretion of proteoglycans. It is a key enzyme for glycosylation of the proteoglycan core. HN - 2024 (1974) BX - beta-D-Xylosyltransferase BX - UDPxylose-Core Protein Xylosyltransferase BX - Xylosyltransferase MH - UK Biobank UI - D000097849 MN - L1.313.500.750.300.188.400.753 MN - L1.470.750.750.753 MS - A biomedical database and research resource that contains genetic and health data on participants aged 40-69 years with a roughly even number of men and women recruited between 2006 and 2010 throughout the UK. HN - 2024 MH - Undertreatment UI - D000097864 MN - N2.421.380.725 MN - N5.300.150.395.725 MS - Remedial treatment or preventive procedures of a disease which is done too infrequently or not enough to control disease diagnosis or treatment. Many factors contribute to medical undertreatment including lack of ACCESS TO HEALTH SERVICES and PATIENT PREFERENCE. HN - 2024 BX - Medical Under-Treatment BX - Medical Undertreatment BX - Under-Treatment MH - Unvaccinated Persons UI - D000096967 MN - M1.927 MS - People who have not been vaccinated against a communicable disease. HN - 2024 BX - Non-Immunized Persons MH - Urea Transporters UI - D000096982 MN - D12.776.157.530.937.941 MN - D12.776.543.585.937.969 MS - Transmembrane carrier proteins responsible for urea movement across the cell membrane. Urea transporters are divided into renal tubular/testicular type (urea transporter 2 consisting of (UT) A1 to A5, encoded by SLC14A2 gene) and erythrocyte type (urea transporter 2 or UT-B1 encoded by the SLC14A1 gene). In humans mutations on the SLC14A1 gene determines KIDD BLOOD-GROUP SYSTEM. HN - 2024 BX - Solute Carrier Family 14 BX - Urea Transporter A BX - Urea Transporter B BX - Urea Transporter Protein A BX - Urea Transporter Protein B BX - Urea Transporter Proteins MH - Ursolic Acid UI - D000097245 MN - D2.455.849.919.530.866 MN - D2.455.849.919.650.800 MS - A pentacyclic triterpene that co-occurs with its isomer OLEANOLIC ACID in several plant species, and occurs in large amounts in FRUITS (such as CRANBERRIES; PEARS; PLUMS; and OLIVES), MEDICINAL HERBS, and other plants. HN - 2024 (1974) BX - (+)-Ursolic Acid BX - (3 beta)-3-Hydroxyurs-12-en-28-oic Acid BX - 3-Epi-Ursolic Acid BX - 3-Epiursolic Acid BX - 3alpha-Ursolic Acid BX - 3beta-Ursolic Acid BX - Olean-12-en-28-oic Acid, 3-Hydroxy-, Sodium Salt (1:1), (3beta)- BX - Sodium Oleanolate BX - Ursolic Acid Monosodium Salt BX - Ursolic Acid Sodium Salt BX - Ursolic Acid, (3beta)-Isomer, 2-(14)C-Labeled BX - Ursolic Acid, (3beta)-Isomer, Monopotassium Salt MH - Venomous Snakes UI - D000097222 MN - B1.50.50.286.875 MN - B1.50.150.900.833.672.562 MS - Snakes that produce SNAKE VENOMS. Venomous snakes are most often members of ELAPIDAE (e.g., cobras) including sea snakes in HYDROPHIINAE and VIPERIDAE (e.g., vipers). HN - 2024 BX - Poisonous Snakes MH - Vernalization UI - D000096384 MN - G7.345.625.968 MN - G15.589.750 MS - The process of thermal induction in plants in which flowering is promoted by prolonged exposure to COLD TEMPERATURE. HN - 2024 BX - Devernalisation BX - Devernalization BX - Seed Stratification BX - Thermomorphogenesis BX - Vernalisation MH - Vipera UI - D000097186 MN - B1.50.50.286.875.875.875.875 MN - B1.50.150.900.833.672.125.937.875.875 MN - B1.50.150.900.833.672.562.875.875.875 MS - A genus of venomous and viviparous vipers in subfamily VIPERINAE. Vipera are found in Africa, Europe and Asia. HN - 2024 MH - Viperinae UI - D000097183 MN - B1.50.50.286.875.875.875 MN - B1.50.150.900.833.672.125.937.875 MN - B1.50.150.900.833.672.562.875.875 MS - A subfamily of snakes commonly known as true vipers or crotaline snakes in the family VIPERIDAE. They are distinguished from sister subfamily CROTALINAE or pit vipers by their lack the heat-sensing pit organs. HN - 2024(1994) MH - Voting UI - D000096264 MN - I1.738.902 MS - Method by which an individual or a group, such as in a meeting or an electorate, can engage for the purpose of making a collective decision or expressing an opinion. HN - 2024 BX - Voter BX - Voters MH - Workforce Diversity UI - D000096966 MN - I1.76.201.450.350.750 MN - I1.880.853.100.450.750 MN - N1.824.245.925.500.500 MN - N4.452.677.975.500.500 MS - Diversity encompasses the range of similarities and differences each individual brings to the workplace, including but not limited to national origin, language, race, color, disability, ethnicity, gender, age, religion, sexual orientation, gender identity, socioeconomic status, veteran status, and family structures. (hud.gov/program_offices/administration/admabout/diversity_inclusion/definitions#diversity) HN - 2024 BX - Diverse Workforce BX - Work Force Diversity BX - Work Place Diversity BX - Workplace Diversity