PMID- 29815391
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29815392
TI  - The Condition Known as "Surgical Kidney".

PMID- 29815393
TI  - The Value and Dangers of "A.C.E." and "C.E." Mixtures.

PMID- 29815394
TI  - Venereal Warts.

PMID- 29815396
TI  - The Cancer Research Fund.

PMID- 29815395
TI  - Ascites-VII: The Differential Diagnosis of the Cause of Ascites (Continued).

PMID- 29815397
TI  - The Treatment of Whitlow.

PMID- 29815398
TI  - Vaccinal Eruptions.

PMID- 29815399
TI  - Anti-Vaccinationists and Modified Smallpox.

PMID- 29815400
TI  - The Ideal Graduate Study Institution.-what Germany Has Done: III. The Kaiserin
      Friedrich Haus.

PMID- 29815401
TI  - Voluntary Aid in War.

PMID- 29815402
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29815404
TI  - Fractures of the Nose.

PMID- 29815403
TI  - The Early Diagnosis of General Paralysis of the Insane.

PMID- 29815406
TI  - Annotations.

PMID- 29815405
TI  - Compound Liquorice Powder in Diabetes.

PMID- 29815407
TI  - Oleo-Brassidate of Mercury Inunctions.

PMID- 29815408
TI  - Isthmus Stenosis or Co-Arctation of the Aorta.

PMID- 29815409
TI  - Melbourne Notes.

PMID- 29815410
TI  - News and Coming Events.

PMID- 29815411
TI  - The Treatment of Patients after Abdominal Section.

PMID- 29815412
TI  - The Mystery of the Borgia Poison.

PMID- 29815414
TI  - The Report of the Commissioners in Lunacy.

PMID- 29815413
TI  - Medical Opinion and Movement.

PMID- 29815415
TI  - The Administrative Side of Sanatorium Work.

PMID- 29815416
TI  - Eruptions Due to Antipyrin.

PMID- 29815417
TI  - Intestinal Obstruction by A Gall-Stone: Symptoms Suggestive of Uraemia.

PMID- 29815418
TI  - Medical Opinion and Movement.

PMID- 29815419
TI  - The Treatment of Hepato-Intestinal Toxaemia.-II.

PMID- 29815420
TI  - Buboes: A Warning.

PMID- 29815421
TI  - Extravagance in the Training School.

PMID- 29815422
TI  - Spasm of the Glottis.

PMID- 29815423
TI  - The Vivisection Commission's Report.

PMID- 29815424
TI  - Enlargement of the Prostate-III.

PMID- 29815425
TI  - Calcium Lactate for Lymphatic Headache, Urticaria, Etc.

PMID- 29815426
TI  - The Local Government Board and Unqualified Practice.

PMID- 29815427
TI  - The Via Media of Dietetics.

PMID- 29815428
TI  - Out-Patient Operations.

PMID- 29815429
TI  - Some Unusual Features of Lead Poisoning.

PMID- 29815430
TI  - Fire Appliances for Use in Hospitals.

PMID- 29815431
TI  - New Appliances & Things Medical.

PMID- 29815433
TI  - Itching and Its Treatment.

PMID- 29815432
TI  - Annotations.

PMID- 29815434
TI  - Practical Points in Children's Feeding.

PMID- 29815435
TI  - News and Coming Events.

PMID- 29815436
TI  - Answers to Correspondents.

PMID- 29815437
TI  - Ascites-IX: The Differential Diagnosis of the Cause of Ascites (concluded).

PMID- 29815438
TI  - Rupture of the Uterus after Caesarean Section.

PMID- 29815439
TI  - Tropical Abscess of the Liver.

PMID- 29815440
TI  - Experiences of a School Medical Officer.

PMID- 29815441
TI  - "Idiopathic" Haematoporphyrinuria.

PMID- 29815442
TI  - The Unenterprising British Practitioner.

PMID- 29815443
TI  - Clinical Tests of Hearing-I.

PMID- 29815444
TI  - Annotations.

PMID- 29815445
TI  - Preventable Blindness.

PMID- 29815446
TI  - News and Coming Events.

PMID- 29815447
TI  - The Addresses at the Belfast Medical Meeting.

PMID- 29815448
TI  - The Feeble-Minded and Their Care.

PMID- 29815449
TI  - A Summer Holiday in North-West America.

PMID- 29815450
TI  - Two Remarkable Cases of Phthisis.

PMID- 29815451
TI  - The Administrative Side of Sanatorium Work.

PMID- 29815452
TI  - Eczema in Babies.

PMID- 29815453
TI  - The Home of Recovery.

PMID- 29815455
TI  - A Case of Intestinal Obstruction with Unusual Features.

PMID- 29815454
TI  - New Appliances and Things Medical.

PMID- 29815456
TI  - Teething as a Cause of Fever.

PMID- 29815457
TI  - Medical Opinion and Movement.

PMID- 29815458
TI  - Reconstruction of the Chelmsford Infirmary.

PMID- 29815459
TI  - Mental Disease Following Influenza.

PMID- 29815460
TI  - Bullous Iodide Rash.

PMID- 29815461
TI  - Gynaecological Diagnosis and the Microscope.

PMID- 29815462
TI  - Some Modern Continental Hospitals.

PMID- 29815463
TI  - Medical Opinion and Movement.

PMID- 29815464
TI  - Two Fatal Cases of Landry's Paralysis.

PMID- 29815465
TI  - Annotations.

PMID- 29815467
TI  - The Sixteenth International Congress of Medicine.

PMID- 29815466
TI  - Surgical Treatment of Acute General Peritonitis.

PMID- 29815468
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29815469
TI  - Institutional Notes and News.

PMID- 29815470
TI  - The Holt Ockley System.

PMID- 29815471
TI  - News and Coming Events.

PMID- 29815472
TI  - Medical Advertising in Japan.

PMID- 29815473
TI  - Cancer Research in the Registrar's Room.

PMID- 29815474
TI  - New Appliances and Things Medical.

PMID- 29815475
TI  - Aseptic Surgery.

PMID- 29815476
TI  - Cut Throat.

PMID- 29815477
TI  - The Strand Palace Hotel.

PMID- 29815478
TI  - The Study of Tropical Medicine.

PMID- 29815479
TI  - The Cambridge University Course.

PMID- 29815480
TI  - Higher Diplomas.

PMID- 29815481
TI  - Opportunities for Graduate Study in Special Hospitals.

PMID- 29815482
TI  - Hospitals and the Rates.

PMID- 29815483
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29815484
TI  - Graduate Study in Scotland and Ireland.

PMID- 29815485
TI  - Graduate Study Abroad.

PMID- 29815487
TI  - The Limitations of Hospital Training.

PMID- 29815486
TI  - Public Health Diplomas.

PMID- 29815488
TI  - London Post-Graduate Institutions.

PMID- 29815489
TI  - "Concentration" and the Future of Medical Education in London.

PMID- 29815490
TI  - The Public Services.

PMID- 29815491
TI  - Qualification and Registration.

PMID- 29815492
TI  - The Scientific Aspects of the Medical Curriculum.

PMID- 29815493
TI  - Oxford University.

PMID- 29815494
TI  - The London University Course.

PMID- 29815495
TI  - The Future of the Public Health Service.

PMID- 29815496
TI  - The English Conjoint Course.

PMID- 29815497
TI  - The Objects and Methods of Medical Education.

PMID- 29815498
TI  - The Medical Schools of the United Kingdom.

PMID- 29815499
TI  - System in the Medical Student's Career.

PMID- 29815500
TI  - Hope Hospital.

PMID- 29815502
TI  - A Case of Subphrenic Abscess with Interesting Features.

PMID- 29815501
TI  - The Treatment of Various Symptoms in Nervous Diseases.

PMID- 29815503
TI  - Secondary Syphilitic Nephritis.

PMID- 29815504
TI  - The Anti-Vivisection Hospital.

PMID- 29815505
TI  - Medical Men and the Workmen's Compensation Act.

PMID- 29815506
TI  - Annotations.

PMID- 29815507
TI  - The Modern Hospital.

PMID- 29815508
TI  - Literary Notes.

PMID- 29815509
TI  - Institutional Notes and News.

PMID- 29815510
TI  - Medical Opinion and Movement.

PMID- 29815511
TI  - The After-Effects of Cerebro-Spinal Meningitis.

PMID- 29815512
TI  - Sclerodermia and Raynaud's Disease.

PMID- 29815513
TI  - The Hygiene of Children's Hair.

PMID- 29815514
TI  - Kangri Cancer.

PMID- 29815515
TI  - Modern X-Ray Apparatus.

PMID- 29815516
TI  - News and Coming Events.

PMID- 29815517
TI  - Notes on Dyspareunia.

PMID- 29815518
TI  - The Medical Mind.

PMID- 29815519
TI  - Practical Notes.

PMID- 29815520
TI  - The Laundry as Part of the Matron's Department.

PMID- 29815521
TI  - The Behaviour of Sequestra.

PMID- 29815522
TI  - Budapest and Buda-Pest.

PMID- 29815523
TI  - Clearing Hospitals for the Territorial Medical Service.

PMID- 29815524
TI  - Tuberculous Disease of the Hip.

PMID- 29815525
TI  - Pregnancy from a Legal Standpoint-IV.

PMID- 29815526
TI  - The First London X-Ray Convention.

PMID- 29815527
TI  - Royal College of Surgeons.

PMID- 29815528
TI  - Annotations.

PMID- 29815530
TI  - Medical Opinion and Movement.

PMID- 29815529
TI  - West Coast Boils Due to Tumbu-Fly Larvae.

PMID- 29815531
TI  - Organic Compounds of Arsenic.

PMID- 29815533
TI  - Examination of the Pupils-I.

PMID- 29815532
TI  - Special Hospitals.

PMID- 29815534
TI  - Seven Years' Working of the Midwives Act.

PMID- 29815535
TI  - The Royal Boscombe and West Hants Hospital.

PMID- 29815536
TI  - News and Coming Events.

PMID- 29815537
TI  - Adolescence.

PMID- 29815538
TI  - London Students and Medical Degrees.

PMID- 29815540
TI  - Asthma and Its Treatment.

PMID- 29815539
TI  - A Criticism of Homoeopathy.

PMID- 29815541
TI  - Post-Graduate Ophthalmology at Oxford.

PMID- 29815542
TI  - Expenses of Motor Upkeep.-II.

PMID- 29815543
TI  - Graduate Study on the Continent-Russia.

PMID- 29815545
TI  - The Hospital Scandal at Bournemouth.

PMID- 29815544
TI  - Some Points in the Diagnosis and Treatment of Disease of the Aortic Valves.

PMID- 29815546
TI  - Torts of Hospitals.

PMID- 29815547
TI  - A Criticism of Hospital Reports.

PMID- 29815548
TI  - Some Prescriptions Discussed-I.

PMID- 29815549
TI  - Phantom Tumours.

PMID- 29815550
TI  - Some Remarks on Mentally Deficient Children.

PMID- 29815551
TI  - Enlargement of the Prostate.-I.

PMID- 29815552
TI  - Pneumococcal Otitis Media by Contagion.

PMID- 29815553
TI  - The Polyclinic Dinner.

PMID- 29815554
TI  - The Dundee Sanatorium Difficulty.

PMID- 29815555
TI  - The Voluntary Notification of Summer Diarrhoea.

PMID- 29815556
TI  - Infantile Mortality in Workhouses.

PMID- 29815557
TI  - Annotations.

PMID- 29815558
TI  - The Need for Well-Educated Probationers.

PMID- 29815559
TI  - Medical Opinion and Movement.

PMID- 29815560
TI  - Graduate Study in America.

PMID- 29815561
TI  - News and Coming Events.

PMID- 29815562
TI  - An Actualisation of the Study of Morbid Inheritance.

PMID- 29815563
TI  - The Therapeutic Value of Hope.

PMID- 29815564
TI  - New Appliances and Things Medical.

PMID- 29815565
TI  - Tonsillectomy.

PMID- 29815566
TI  - The Operative Treatment of Carcinoma Mammae.

PMID- 29815567
TI  - The Question of the Registration Fee.

PMID- 29815568
TI  - Medical Opinion and Movement.

PMID- 29815569
TI  - Medical Advertising.

PMID- 29815570
TI  - Provident and Charitable Medical Assistance or State Medicine.

PMID- 29815571
TI  - The Dental Hospital of Manchester.

PMID- 29815572
TI  - The Treatment of Whooping-Cough-I.

PMID- 29815573
TI  - Running for Boys.

PMID- 29815574
TI  - The Surgical Treatment of Tuberculous Glands.

PMID- 29815575
TI  - Potassium Iodide and Citrates in Pneumonia.

PMID- 29815576
TI  - Sheep's Thyroid Gland in the Cure of Sclerodermia.

PMID- 29815577
TI  - The Untruthfulness of Patients.

PMID- 29815579
TI  - News and Coming Events.

PMID- 29815578
TI  - Latent Diseases.

PMID- 29815580
TI  - Annotations.

PMID- 29815581
TI  - Jaundice without Bile Pigments in the Urine.

PMID- 29815582
TI  - Skodaic Resonance in Lobar Pneumonia.

PMID- 29815583
TI  - The Territorial Regimental Surgeon and Sanitary Instruction.

PMID- 29815584
TI  - London's Ambulance Service.

PMID- 29815585
TI  - Where a Certified Case May Be Treated.

PMID- 29815586
TI  - Practical Hints for Operations on the Ear.

PMID- 29815587
TI  - Apparent Amenorrhoea.

PMID- 29815588
TI  - Some More Incompatible Prescriptions.

PMID- 29815589
TI  - The Causation and Treatment of Scoliosis.

PMID- 29815590
TI  - The Relations of Cancer to Chronic Inflammation.

PMID- 29815591
TI  - A Series of Ten Cases of Complete Rupture of the Uterus.

PMID- 29815592
TI  - Annotations.

PMID- 29815593
TI  - News and Coming Events.

PMID- 29815594
TI  - A Study of Dabchicks.

PMID- 29815595
TI  - Spinal Analgesia.

PMID- 29815596
TI  - Acid-Fast Bacilli in Non-Tuberculous Sputum.

PMID- 29815597
TI  - The Cost of Nursing per Bed.

PMID- 29815598
TI  - New Appliances & Things Medical.

PMID- 29815599
TI  - Hospitals and the Budget.

PMID- 29815600
TI  - The Ideal Graduate Study Institution.-What Germany Has Done.

PMID- 29815601
TI  - Sanitation in the West Indies.

PMID- 29815602
TI  - Medical Opinion and Movement.

PMID- 29815603
TI  - The Causation of Epidemics.

PMID- 29815605
TI  - Rest and Pain.

PMID- 29815604
TI  - Illegal Cremation.

PMID- 29815606
TI  - Circumcision and Its Abuses.

PMID- 29815607
TI  - Ascites-IV.

PMID- 29815608
TI  - Acetone Applications in the Relief of Ulcerating Cancer.

PMID- 29815609
TI  - Southport Homoeopathic Hospital.

PMID- 29815610
TI  - Ascites-III.

PMID- 29815611
TI  - Haemorrhages in the Later Months of Pregnancy.

PMID- 29815612
TI  - The Use of Whey in Infant Feeding.

PMID- 29815613
TI  - The Treatment of Glottic Spasm.

PMID- 29815615
TI  - The Lost Art of Prescribing.

PMID- 29815614
TI  - The Hospital Treatment of Infectious Cases.

PMID- 29815616
TI  - Short Practical Notes for Medical Motorists.

PMID- 29815618
TI  - The Parentage of British Medical Men of Eminence.

PMID- 29815617
TI  - Clinical Demonstration of Selected Skin Cases.

PMID- 29815619
TI  - Literary Notes.

PMID- 29815620
TI  - The Cost of the Hospital Nurse.

PMID- 29815622
TI  - Medical Opinion and Movement.

PMID- 29815621
TI  - Mechanics and Dynamics of Intractable Constipation.

PMID- 29815623
TI  - Papilloma of the Bladder.

PMID- 29815624
TI  - The Electrolytic or Ionic Administration of Drugs.

PMID- 29815625
TI  - New Appliances and Things Medical.

PMID- 29815626
TI  - Annotations.

PMID- 29815627
TI  - Experiments on Living Animals.

PMID- 29815628
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29815629
TI  - Answers to Correspondents.

PMID- 29815630
TI  - News and Coming Events.

PMID- 29815631
TI  - A New Electric Horn for Motorists.

PMID- 29815632
TI  - Annotations.

PMID- 29815633
TI  - The Chemists' Exhibition.

PMID- 29815634
TI  - News and Coming Events.

PMID- 29815635
TI  - Tuberculosis in India.

PMID- 29815636
TI  - The Financial Problem of the Voluntary Hospitals.

PMID- 29815637
TI  - A Clinical Lecture on a Case of Ulcerative Colitis.

PMID- 29815638
TI  - The Prevention of Tuberculosis in Cattle.

PMID- 29815639
TI  - The Savoy Baths.

PMID- 29815640
TI  - Hepato-Intestinal Toxaemia.-I.

PMID- 29815641
TI  - Enlargement of the Prostate-II.

PMID- 29815642
TI  - Notes on an Unusual Case of Hydatid Cyst.

PMID- 29815643
TI  - The Groundwork of Eugenics.

PMID- 29815644
TI  - A Few Practical Points in Certification.

PMID- 29815645
TI  - New Appliances and Things Medical.

PMID- 29815646
TI  - Water Drinking in the Treatment of Chronic Constipation.

PMID- 29815648
TI  - Conditions Simulating Enlargement of the Liver.-II.

PMID- 29815647
TI  - The Patients' Rights.

PMID- 29815649
TI  - Medical Opinion and Movement.

PMID- 29815650
TI  - The Territorial Brigade Camp Hospitals.

PMID- 29815651
TI  - Melbourne Notes.

PMID- 29815653
TI  - Tuberculous Peritonitis Treated without Operation.

PMID- 29815652
TI  - Practical Hints.

PMID- 29815654
TI  - Journalism.

PMID- 29815655
TI  - The Motives Proper to the Physician.

PMID- 29815656
TI  - Organic Iron Compounds.

PMID- 29815657
TI  - Purley Cottage Hospital.

PMID- 29815658
TI  - An Incinerator for Infected Materials.

PMID- 29815659
TI  - Operations for Appendicitis.

PMID- 29815661
TI  - The Vaccine Treatment of Pneumonia.

PMID- 29815660
TI  - Some Intracranial Vascular Lesions.

PMID- 29815662
TI  - News and Coming Events.

PMID- 29815663
TI  - "The Hospital" Commission and Beer and Stout.

PMID- 29815664
TI  - Annotations.

PMID- 29815666
TI  - Medical Opinion and Movement.

PMID- 29815665
TI  - Paralysis Agitans.

PMID- 29815667
TI  - Speedometer and Consumeter.

PMID- 29815668
TI  - New Appliances & Things Medical.

PMID- 29815669
TI  - Anti-Vaccinationists and Modified Smallpox.

PMID- 29815671
TI  - Some General Aspects of Poisons-II.

PMID- 29815670
TI  - The Administrative Side of Sanatorium Work.

PMID- 29815673
TI  - The Teaching of Temperance.

PMID- 29815672
TI  - The Pathological Changes Which May Occur in Uterine Fibroids.

PMID- 29815674
TI  - Annotations.

PMID- 29815675
TI  - Notes on the Ophthalmological Aspects of Nystagmus.

PMID- 29815676
TI  - How to See a Larynx.

PMID- 29815677
TI  - Xanthoma Diabeticorum.

PMID- 29815678
TI  - The Diagnosis of Diseases of the Rectum and Anus.

PMID- 29815679
TI  - Practical Hints for Medical Motorists.

PMID- 29815680
TI  - Acute Non-Gonococcal Epididymo-Orchitis.

PMID- 29815681
TI  - A Case of Acute Dilatation of the Stomach.

PMID- 29815683
TI  - New Appliances & Things Medical.

PMID- 29815682
TI  - Nutrient Media in the Local Treatment of Ulcers.

PMID- 29815685
TI  - Immunisation: A Criticism of Current Theory and Practice.

PMID- 29815684
TI  - Medical Opinion and Movement.

PMID- 29815686
TI  - The Ideal Graduate Study Institution.

PMID- 29815687
TI  - Literary Notes.

PMID- 29815688
TI  - The Administrative Side of Sanatorium Work.

PMID- 29815689
TI  - Paroxysmal Sneezing and Hay Asthma.

PMID- 29815691
TI  - Demoralising Books.

PMID- 29815690
TI  - London and Counties Medical Protection Society : Notice.

PMID- 29815692
TI  - News and Coming Events.

PMID- 29815693
TI  - Ascites-V: The Differential Diagnosis of the Cause of Ascites.

PMID- 29815695
TI  - The New Pathological Block of St. Bartholomew's Hospital.

PMID- 29815694
TI  - Aural Furunculosis.

PMID- 29815696
TI  - Diagram of the Weekly Death Rate in 1909.

PMID- 29815697
TI  - The Best Splints for Bow Legs.

PMID- 29815698
TI  - Medical Expert Evidence.-I.

PMID- 29815699
TI  - Beri-Beri.

PMID- 29815700
TI  - A Special Report on Their Preparation, and Their Chemical, Physiological and
      Dietetic Properties.

PMID- 29815701
TI  - Congenital Muscular Atony.

PMID- 29815702
TI  - The Territorial Regimental Surgeon and First-Aid Instruction.

PMID- 29815703
TI  - Medical Opinion and Movement.

PMID- 29815705
TI  - The Biological Factor in Infant Feeding.

PMID- 29815704
TI  - A Criticism of Homoeopathy.

PMID- 29815706
TI  - Hospital Saturday Fund.

PMID- 29815707
TI  - Annotations.

PMID- 29815708
TI  - Social and Poor-Law Problems.

PMID- 29815709
TI  - The Revision of the British Pharmacopoeia.

PMID- 29815710
TI  - The Value of Sanatorium Treatment.

PMID- 29815711
TI  - Examination of the Pupils.-III.

PMID- 29815712
TI  - Some Unusual Swellings of the Abdominal Parietes.

PMID- 29815713
TI  - Proprietary Preparations Falsely Described.

PMID- 29815714
TI  - The Doctrine of Signatures.

PMID- 29815715
TI  - Genu Valgum.

PMID- 29815716
TI  - Another X-Ray Scare.

PMID- 29815717
TI  - News and Coming Events.

PMID- 29815718
TI  - Sulphur in the Treatment of Thread-Worms.

PMID- 29815719
TI  - Some Advantages of a Declining Birth-Rate.

PMID- 29815720
TI  - New Appliances & Things Medical.

PMID- 29815721
TI  - Graduate Study in America.

PMID- 29815722
TI  - The Inwardness of Spring Time.

PMID- 29815723
TI  - The Zittman Treatment of Syphilis.

PMID- 29815724
TI  - News and Coming Events.

PMID- 29815725
TI  - Alarming Symptoms after A Dose of Aspirin.

PMID- 29815726
TI  - Diagnosis and Treatment of Pyometra.

PMID- 29815727
TI  - The Ideal Graduate Study Institution.-What Germany Has Done.

PMID- 29815728
TI  - Buttermilk for Urticaria in Children.

PMID- 29815729
TI  - Annotations.

PMID- 29815730
TI  - Ascites-VI: The Differential Diagnosis of the Cause of Ascites (Continued).

PMID- 29815731
TI  - Reform in the West African Medical Service.

PMID- 29815732
TI  - The Significance of Peri-Renal Suppuration.

PMID- 29815734
TI  - Literary Notes.

PMID- 29815733
TI  - The Cerebellum.

PMID- 29815735
TI  - Sprained Ankle-II.

PMID- 29815736
TI  - Medical Opinion and Movement.

PMID- 29815737
TI  - Diagnosis of Diseases of the Urinary System.

PMID- 29815738
TI  - The Use and Abuse of Nursing Congresses.

PMID- 29815739
TI  - New Appliances & Things Medical.

PMID- 29815740
TI  - Self-Procured Abortion.

PMID- 29815741
TI  - Answers to Correspondents.

PMID- 29815742
TI  - Medical Opinion and Movement.

PMID- 29815743
TI  - The Popular Treatment of Medical Subjects.

PMID- 29815744
TI  - Queen Victoria's Jubilee Institute for Nurses.

PMID- 29815745
TI  - News and Coming Events.

PMID- 29815746
TI  - The Difficulties of Occipito-Posterior Presentations.

PMID- 29815747
TI  - Ascites-II.

PMID- 29815748
TI  - Nasal Discharge.-III.

PMID- 29815749
TI  - Annotations.

PMID- 29815750
TI  - Contractures and Deformities of the Hand.

PMID- 29815751
TI  - Lactic Acid Preparations.

PMID- 29815753
TI  - Hospital Sunday and Some Critics.

PMID- 29815752
TI  - Sprained Ankle.

PMID- 29815754
TI  - Prognosis in Pulmonary Tuberculosis.

PMID- 29815755
TI  - The Educational Influence of Sanatorium Treatment.

PMID- 29815756
TI  - Scopolamine for Tremor.

PMID- 29815757
TI  - The Influence of Drying upon Various Bacteria.

PMID- 29815758
TI  - The Typhoid Carrier Problem.

PMID- 29815759
TI  - Night Blindness and Day Blindness.

PMID- 29815760
TI  - Insanity as a Defence in the Criminal Courts-I.

PMID- 29815761
TI  - Some Remarks on Hernia: II. The Diagnosis and Treatment of Inguinal Hernia.

PMID- 29815762
TI  - Oxaluria-II.

PMID- 29815763
TI  - Tuberculous Disease of the Knee Joint-II.

PMID- 29815764
TI  - The Campaign against Malaria.

PMID- 29815766
TI  - News and Coming Events.

PMID- 29815765
TI  - Medical Opinion and Movement.

PMID- 29815767
TI  - X-Rays in the Treatment of Diseases of the Skin.

PMID- 29815768
TI  - The Out-Patient Problem.

PMID- 29815769
TI  - Graduate Study on the Continent.

PMID- 29815770
TI  - The Sessional Addresses.

PMID- 29815771
TI  - Notes on Brain Fever.

PMID- 29815772
TI  - The Prevention of Tuberculosis.

PMID- 29815773
TI  - The Pathology of Herpes Zoster.

PMID- 29815774
TI  - Pigmentation and the Diagnosis of Addison's Disease.

PMID- 29815775
TI  - Biliary Nephritis.

PMID- 29815776
TI  - Annotations.

PMID- 29815777
TI  - Recent Views on Cerebro-Spinal Meningitis.

PMID- 29815778
TI  - The Matron's Part in the Territorial Army.

PMID- 29815779
TI  - Induction of Labour.

PMID- 29815780
TI  - Retropharyngeal Abscess in Children.

PMID- 29815781
TI  - The Domestic Staff-VI: Economy in Numbers.

PMID- 29815782
TI  - Prescriptions and Dispensing.-Ointments.

PMID- 29815783
TI  - News and Coming Events.

PMID- 29815784
TI  - Graduate Study on the Continent-Germany.

PMID- 29815785
TI  - The X-Rays in Phthisis Pulmonalis.

PMID- 29815786
TI  - Social and Poor-Law Problems.

PMID- 29815788
TI  - Practical Hints upon Medical Examination for Life Assurance-V.

PMID- 29815787
TI  - The Relation between Vitality and Bulk.

PMID- 29815789
TI  - Acidosis, or Acetonaemia.

PMID- 29815790
TI  - Improvements at the "Dreadnought" Hospital.

PMID- 29815791
TI  - Two Minor Operations in Laryngology.

PMID- 29815793
TI  - Enlargements of the Spleen-IX: Splenic Enlargements in which the Blood Changes
      are not Distinctive.

PMID- 29815792
TI  - The Varieties, Causation, and Treatment of Appendicitis.

PMID- 29815794
TI  - Medical Opinion and Movement.

PMID- 29815795
TI  - Tuberculous Disease of the Knee-Joint.

PMID- 29815796
TI  - Annotations.

PMID- 29815797
TI  - Moribund Patients in Hospital.

PMID- 29815798
TI  - Medical Opinion and Movement.

PMID- 29815800
TI  - News and Coming Events.

PMID- 29815799
TI  - Glassworker's and Telegraphist's Diseases.

PMID- 29815801
TI  - Fleas and Babies.

PMID- 29815802
TI  - New Appliances and Things Medical.

PMID- 29815803
TI  - Registration Difficulties.-IV.

PMID- 29815804
TI  - Some Remarks on Hernia: VI. The Treatment of a Strangulated Hernia.

PMID- 29815805
TI  - On Growing Old.

PMID- 29815806
TI  - Some Notes on Phthisis-I: Tobacco-Smoking and Tuberculosis.

PMID- 29815807
TI  - Asthenic Cases.

PMID- 29815808
TI  - The Treatment of Surgical Tuberculous Affections with Tuberculin (T.R.).

PMID- 29815809
TI  - Some Modern Continental Hospitals.

PMID- 29815810
TI  - The Sterilisation of Water for Troops in the Field.

PMID- 29815811
TI  - The Causes and Treatment of Abortion.

PMID- 29815813
TI  - Renal Tube Casts without Albuminuria.

PMID- 29815812
TI  - Prescriptions and Dispensing.

PMID- 29815814
TI  - Quaint Cures and Prescriptions.

PMID- 29815815
TI  - Introductory.

PMID- 29815816
TI  - The Removal of Tophi.

PMID- 29815817
TI  - Annotations.

PMID- 29815818
TI  - Raynaud's Disease I.

PMID- 29815819
TI  - The Mode of Infection in Kala-Azar.

PMID- 29815820
TI  - Mr. Keetley's Paper on the Advantages of Appendicostomy.

PMID- 29815822
TI  - Some Chronic Joint Lesions Following Injury.-II.

PMID- 29815821
TI  - Provident Dispensaries and the Treatment of Diseases in School Children.

PMID- 29815823
TI  - A Note upon the Importance of Barium Salts.

PMID- 29815824
TI  - Sexual Perversion-II.

PMID- 29815825
TI  - The Objects of Science.

PMID- 29815827
TI  - Some Modern Continental Hospitals.

PMID- 29815826
TI  - Better Training for Matrons.

PMID- 29815828
TI  - New Appliances and Things Medical.

PMID- 29815829
TI  - News and Coming Events.

PMID- 29815830
TI  - The Immediate Treatment of Puerperal Sepsis.

PMID- 29815831
TI  - Medical Opinion and Movement.

PMID- 29815832
TI  - The Management of Cases of Chronic Aural Suppuration.

PMID- 29815833
TI  - Pyelitis in Children.

PMID- 29815834
TI  - Notes on Current Topics.

PMID- 29815835
TI  - Annotations.

PMID- 29815837
TI  - Calcium Increase in Blood.

PMID- 29815836
TI  - A Great Example.

PMID- 29815838
TI  - Laryngeal Crisis or Potassium Iodide Poisoning?

PMID- 29815839
TI  - Hydatidiform Mole.

PMID- 29815840
TI  - Conservative Dentistry.

PMID- 29815841
TI  - Marginal Blepharitis.

PMID- 29815842
TI  - Diet and Diet Fads.

PMID- 29815843
TI  - Annotations.

PMID- 29815844
TI  - Ganglion.

PMID- 29815845
TI  - Bismuth Soup and X-Rays in OEsophageal Obstruction.

PMID- 29815846
TI  - Medical Opinion and Movement.

PMID- 29815847
TI  - The Cottage Hospital at Holywell, Flintshire.

PMID- 29815848
TI  - Enlargement of the Tonsils-IV.

PMID- 29815849
TI  - The Diagnosis of Lobar Pneumonia in Children.

PMID- 29815850
TI  - News and Coming Events.

PMID- 29815851
TI  - Medical Exhibitions.

PMID- 29815852
TI  - The Causes and Treatment of Diarrhoea-III.

PMID- 29815853
TI  - Registration Difficulties.-II.

PMID- 29815854
TI  - Graduate Study on the Continent-Austria: III. The University of Vienna and its
      Courses.

PMID- 29815856
TI  - New Appliances and Things Medical.

PMID- 29815855
TI  - The Treatment of Inguinal Hernia in Young Children.

PMID- 29815857
TI  - Recent Views on Tuberculosis.

PMID- 29815858
TI  - Is Blackwater Fever a Form of Malaria?

PMID- 29815859
TI  - The Need for Monopolising the Milk Supply.

PMID- 29815860
TI  - Tuberculous Disease of the Knee-Joint.

PMID- 29815861
TI  - On Malingering.

PMID- 29815862
TI  - The Domestic Staff-VII: How to Reduce Expenditure.

PMID- 29815863
TI  - Alopecia Areata.

PMID- 29815864
TI  - The After-Results of Injuries.

PMID- 29815865
TI  - Carneous Mole.

PMID- 29815866
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29815867
TI  - The Foggy Days.

PMID- 29815868
TI  - Medical Opinion and Movement.

PMID- 29815869
TI  - The Sensory Phenomena of Tabes Dorsalis.

PMID- 29815870
TI  - Sheffield Royal Hospital Annexe at Fulwood.

PMID- 29815871
TI  - Annotations.

PMID- 29815872
TI  - Prescriptions and Dispensing.

PMID- 29815873
TI  - Enlargement of the Spleen-X: Enlargements in which the Blood Changes are not
      Distinctive (Concluded).

PMID- 29815874
TI  - News and Coming Events.

PMID- 29815875
TI  - The Hearsey Treatment of Blackwater Fever.

PMID- 29815876
TI  - Coal-Miners' Nystagmus.

PMID- 29815877
TI  - Bonney's Rapid Triple Stain.

PMID- 29815878
TI  - Strangulated Hernia-V.

PMID- 29815880
TI  - Rheumatic Nodules.

PMID- 29815879
TI  - Medical Opinion and Movement.

PMID- 29815881
TI  - Operations in the Nose and Naso-Pharynx.

PMID- 29815882
TI  - New Appliances and Things Medical.

PMID- 29815883
TI  - The Causes and Treatment of Diarrhoea-IV.

PMID- 29815884
TI  - Prognosis in Congenital Heart Disease.

PMID- 29815885
TI  - Annotations.

PMID- 29815886
TI  - Children's Wards.

PMID- 29815887
TI  - The Present-Day Treatment of Laryngeal Tuberculosis.

PMID- 29815888
TI  - Suprarenal Extract in Osteomalacia and Rickets.

PMID- 29815889
TI  - Registration Difficulties-III.

PMID- 29815890
TI  - Vaccination Rashes.

PMID- 29815891
TI  - Medical and Insurance Problems.

PMID- 29815892
TI  - News and Coming Events.

PMID- 29815893
TI  - King's Norton Union Infirmary.

PMID- 29815894
TI  - Training Schools in Relation to Size.

PMID- 29815895
TI  - The New Manchester Royal Infirmary.

PMID- 29815896
TI  - Annotations.

PMID- 29815897
TI  - Mumps.

PMID- 29815899
TI  - Calcium Soaps as a Factor in Appendicitis.

PMID- 29815898
TI  - New Appliances and Things Medical.

PMID- 29815900
TI  - Portable Electric Lamps.

PMID- 29815901
TI  - Fractures in General Practice.

PMID- 29815902
TI  - Medical Opinion and Movement.

PMID- 29815904
TI  - A Few Points in the Examination of Mental Cases.

PMID- 29815903
TI  - Sleeping Sickness.

PMID- 29815905
TI  - The Diagnosis of Perforated Gastric Ulcer.

PMID- 29815906
TI  - Insanity as a Defence in the Criminal Courts-II.

PMID- 29815907
TI  - The Causes and Treatment of Diarrhoea.-I.

PMID- 29815908
TI  - Some Drug Reactions in Urine.

PMID- 29815909
TI  - Some Remarks on Hernia: III. Bassini's Operation for Radical Cure of an Inguinal
      Hernia.

PMID- 29815910
TI  - Inflammation.

PMID- 29815911
TI  - Women and the Royal College of Surgeons.

PMID- 29815912
TI  - Larger Medicine.

PMID- 29815913
TI  - News and Coming Events.

PMID- 29815914
TI  - The So-Called Third Heart-Sound.

PMID- 29815915
TI  - Annotations.

PMID- 29815916
TI  - The Use of Ethyl Chloride by the General Practitioner.

PMID- 29815917
TI  - The Causes and Treatment of Diarrhoea-II.

PMID- 29815918
TI  - Oatmeal in Diabetes Mellitus.

PMID- 29815919
TI  - Heredity in Relation to Disease.

PMID- 29815920
TI  - New Appliances & Things Medical.

PMID- 29815921
TI  - Some Modern Continental Hospitals.

PMID- 29815922
TI  - Orthopaedic Work in General Practice-I.

PMID- 29815923
TI  - The Progress of Cancer Research.

PMID- 29815924
TI  - Prescriptions and Dispensing: Compressed Tablets.

PMID- 29815925
TI  - Some General Principles in the Treatment of Fracture Cases.

PMID- 29815926
TI  - News and Coming Events.

PMID- 29815927
TI  - Medical Opinion and Movement.

PMID- 29815928
TI  - Albuminuric Retinitis, and Its Bearing on Prognosis.

PMID- 29815930
TI  - Atoxyl in Syphilis.

PMID- 29815929
TI  - Insanity as a Defence in the Criminal Courts-III.

PMID- 29815931
TI  - Registration Difficulties-I.

PMID- 29815932
TI  - Cases Illustrating Symptoms Referable to the Ends of the Extremities.

PMID- 29815933
TI  - Tuberculous Peritonitis.

PMID- 29815934
TI  - Anaesthetisation for Operations on the Bladder and Urethra.

PMID- 29815935
TI  - Hospital Sunday Fund.

PMID- 29815936
TI  - The Influence of Position upon Pain.

PMID- 29815937
TI  - The Report of the Committee on the Inebriates Acts-II.

PMID- 29815938
TI  - An Anti-Vivisectionist Manifesto.

PMID- 29815939
TI  - Direct Examination of the Larynx, Trachea, and OEsophagus.

PMID- 29815940
TI  - Sour Milk in Rheumatoid Arthritis.

PMID- 29815942
TI  - Annotations.

PMID- 29815941
TI  - Sporotrichosis.

PMID- 29815943
TI  - Lecithin in Neurasthenia, and in Graves' Disease.

PMID- 29815944
TI  - The Business Side of Practice.

PMID- 29815945
TI  - The House Surgeon and the Stethoscope.

PMID- 29815946
TI  - The Hyperaemic Method of Treatment-II.

PMID- 29815947
TI  - Better Training for Matrons.

PMID- 29815948
TI  - Some Points about Head Injuries.

PMID- 29815949
TI  - The Heating and Lighting of Hospital Wards.

PMID- 29815950
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29815951
TI  - The City Hospital for Infectious Diseases, Walker Gate, Newcastle.

PMID- 29815952
TI  - The Therapeutic Value of the Rectum in the Treatment of Disease in Children.

PMID- 29815953
TI  - The British Medical Library Association.

PMID- 29815954
TI  - The Territorial Regimental Surgeon.

PMID- 29815955
TI  - Medical Opinion and Movement.

PMID- 29815957
TI  - News and Coming Events.

PMID- 29815956
TI  - News and Coming Events.

PMID- 29815958
TI  - Annotations.

PMID- 29815959
TI  - Some Remarks on Hernia.

PMID- 29815961
TI  - Medical Opinion and Movement.

PMID- 29815960
TI  - The Diagnosis of Facial Erysipelas.

PMID- 29815962
TI  - The Royal Army Medical Corps Training Manual.

PMID- 29815964
TI  - The Differential Diagnosis of Multiple Glandular Swellings-II.

PMID- 29815963
TI  - The Preparation and After-Treatment of Abdominal Operations.

PMID- 29815965
TI  - Registration Difficulties.

PMID- 29815966
TI  - Grants to Extra-Metropolitan Hospitals.

PMID- 29815967
TI  - Collecting Antique Furniture.

PMID- 29815968
TI  - Male Fern in Chronic Tuberculous Affections.

PMID- 29815969
TI  - The Emmanuel Idea.

PMID- 29815971
TI  - Medical Inspection of School Children.

PMID- 29815970
TI  - A Case of Enteric Fever.

PMID- 29815972
TI  - Examination of the Achillis-Jerk.

PMID- 29815973
TI  - The League of Mercy.

PMID- 29815974
TI  - The Value of the Preliminary Sciences.

PMID- 29815975
TI  - The Passing of Murphy's Button.

PMID- 29815976
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29815978
TI  - Pregnancy from a Legal Standpoint-II.

PMID- 29815977
TI  - Parents, Children and the State.

PMID- 29815979
TI  - Methylene Blue in the Cure of Ulcerative Stomatitis.

PMID- 29815981
TI  - Retention of Urine and Its Treatment.

PMID- 29815980
TI  - The Intermittent Infectiousness of Scarlet Fever.

PMID- 29815982
TI  - The Effect of Tyre Size.

PMID- 29815983
TI  - Bursal Cysts in Connection with the Knee-Joint.

PMID- 29815984
TI  - News and Coming Events.

PMID- 29815985
TI  - New Appliances & Things Medical.

PMID- 29815986
TI  - A Review of Its Medical Aspects.

PMID- 29815987
TI  - Elastic Fibres in Sputum.

PMID- 29815988
TI  - Blood Cultures in the Early Diagnosis of Enteric Fever.

PMID- 29815990
TI  - Scotch Hospitals and Registration.

PMID- 29815989
TI  - Late Childhood and Boarding Schools.

PMID- 29815991
TI  - Thiosinamine and Fibrolysin in Skin Affections.

PMID- 29815993
TI  - The Progress of the Research Defence Society.

PMID- 29815992
TI  - Annotations.

PMID- 29815995
TI  - Alcohol and Drink.

PMID- 29815994
TI  - A Plague Report from Sydney.

PMID- 29815996
TI  - Medical Opinion and Movement.

PMID- 29815998
TI  - The Immediate Treatment of Puerperal Sepsis.-I.

PMID- 29815997
TI  - The Diagnosis and Treatment of Haemorrhage in Typhoid Fever.

PMID- 29815999
TI  - Literary Notes.

PMID- 29816000
TI  - A Backward Glance at Surgery in 1908.

PMID- 29816001
TI  - Religion and Medicine.

PMID- 29816002
TI  - Administrative Progress Throughout 1908.

PMID- 29816003
TI  - Acute Otitis Media.

PMID- 29816004
TI  - News and Coming Events.

PMID- 29816005
TI  - Prescriptions and Dispensing.

PMID- 29816006
TI  - Annotations.

PMID- 29816007
TI  - The Diagnosis and Treatment of Quinsy.

PMID- 29816009
TI  - Graduate Study on the Continent-Austria.

PMID- 29816008
TI  - The Hyperaemic Method of Treatment.-I.

PMID- 29816010
TI  - Some Hospital Finance in 1908.

PMID- 29816011
TI  - The Reaction of Degeneration.

PMID- 29816012
TI  - Doctors' Cars at the Motor Show.-II.

PMID- 29816013
TI  - Rheumatic Fever and Its Treatment.

PMID- 29816014
TI  - Medical Opinion and Movement.

PMID- 29816015
TI  - The R.M.O. and outside Emergency Calls.

PMID- 29816016
TI  - A Survey of Medicine in 1908.

PMID- 29816017
TI  - Purpura Rheumatica.

PMID- 29816018
TI  - Anti-Vivisectionists and the Hospital Sunday Fund.

PMID- 29816019
TI  - The Balcony Question in Hospitals.

PMID- 29816020
TI  - Trachoma.

PMID- 29816021
TI  - A Spectroscopic Test of Colour Vision.

PMID- 29816023
TI  - Some Remarks on Hernia: IV. Irreducibility.

PMID- 29816022
TI  - Persistent Jaundice and Splenomegaly in Young Persons.

PMID- 29816025
TI  - The AEtiology of Rickets.

PMID- 29816024
TI  - A Hospital Problem.

PMID- 29816026
TI  - The Prevention of Tuberculosis in Ireland.

PMID- 29816027
TI  - News and Coming Events.

PMID- 29816028
TI  - The Congresses-And after.

PMID- 29816029
TI  - Acute Rheumatoid Arthritis.

PMID- 29816030
TI  - Graduate Study on the Continent-Austria.

PMID- 29816031
TI  - Annotations.

PMID- 29816032
TI  - The "Water Duties" Personnel of the Territorial Army.

PMID- 29816033
TI  - The Proper Treatment of Tubal Gestation.

PMID- 29816035
TI  - Medical Opinion and Movement.

PMID- 29816034
TI  - The Barber, the Surgeon, and the Taster.

PMID- 29816037
TI  - The Treatment of Eczema.

PMID- 29816036
TI  - The Registration Campaign.

PMID- 29816038
TI  - The Detection of Early Pulmonary Tubercle.

PMID- 29816039
TI  - Enlargement of the Tonsils-III.

PMID- 29816040
TI  - New Appliances and Things Medical.

PMID- 29816041
TI  - Euphorbia in Asthma and Bronchitis.

PMID- 29816042
TI  - Syphilis Maligna Praecox and Its Treatment.

PMID- 29816044
TI  - The Hospital for Diseases of the Skin, Blackfriars.

PMID- 29816043
TI  - The AEtiology of Malignant Disease.

PMID- 29816045
TI  - Graduate Study on the Continent-Austria.

PMID- 29816046
TI  - The Heating and Lighting of Hospital Wards.

PMID- 29816047
TI  - New Methods of Administration of Ether.

PMID- 29816048
TI  - Annotations.

PMID- 29816049
TI  - New Appliances and Things Medical.

PMID- 29816050
TI  - Medical Opinion and Movement.

PMID- 29816051
TI  - News and Coming Events.

PMID- 29816052
TI  - An Anti-Vivisection Manifesto.

PMID- 29816054
TI  - The Hyperaemic Method of Treatment-III.

PMID- 29816053
TI  - Some Points about Head Injuries.

PMID- 29816056
TI  - Better Training for Matrons.

PMID- 29816055
TI  - Swooning and Syncope.

PMID- 29816057
TI  - Venomous British Fishes.

PMID- 29816058
TI  - Rose-Coloured Ringworm Cultures.

PMID- 29816059
TI  - The Medicinal Mountebank.

PMID- 29816060
TI  - More about Human and Bovine Tuberculosis.

PMID- 29816061
TI  - Sulphuric Acid by the Mouth in Furunculosis.

PMID- 29816062
TI  - Chylous Ascites in Bright's Disease.

PMID- 29816064
TI  - Preliminary Schools for Probationers.

PMID- 29816063
TI  - City and Provincial Appointments.

PMID- 29816066
TI  - A Review of Its Medical Aspects.-II.

PMID- 29816065
TI  - The Relations of the Voluntary Hospitals to the Poor-Law Authorities.

PMID- 29816068
TI  - Medical Opinion and Movement.

PMID- 29816067
TI  - The Diagnosis between Pyloric Colic and Biliary Colic.

PMID- 29816069
TI  - News and Coming Events.

PMID- 29816071
TI  - Whisky, Wine and Beer.

PMID- 29816070
TI  - The Intermittent Infectiousness of Scarlet Fever.

PMID- 29816072
TI  - Annotations.

PMID- 29816073
TI  - The Appointment and Conditions of Service of the Territorial Regimental Surgeon.

PMID- 29816074
TI  - A Case for Diagnosis.

PMID- 29816075
TI  - New Infirmary, Alnwick.

PMID- 29816076
TI  - Lumbar Operations on the Kidneys.

PMID- 29816078
TI  - A Rapid Method of Curing Itch.

PMID- 29816077
TI  - Some Features of Exophthalmic Goitre.

PMID- 29816079
TI  - Cerebro-Spinal Lymphocytes in General Paralysis of the Insane.

PMID- 29816080
TI  - Some Injuries to the Vertebral Column.

PMID- 29816081
TI  - Uterine Haemorrhage at the Menopause.

PMID- 29816083
TI  - Water Softening in Hospitals.

PMID- 29816082
TI  - The Heating and Lighting of Hospital Wards.

PMID- 29816084
TI  - Valvular Lesions without Bruit.

PMID- 29816085
TI  - The Medical Graduates' College and Polyclinic.

PMID- 29816086
TI  - Innocent Laryngeal Growths-II.

PMID- 29816087
TI  - Sudden Blindness.

PMID- 29816088
TI  - Tuberculosis of the Male Genital Tract.

PMID- 29816089
TI  - Medical Opinion and Movement.

PMID- 29816090
TI  - Annotations.

PMID- 29816091
TI  - The Heating and Lighting of Hospital Wards.

PMID- 29816092
TI  - A Dietary for Mucous Colitis.

PMID- 29816093
TI  - Better Training for Matrons.

PMID- 29816094
TI  - Left-Handedness.

PMID- 29816095
TI  - News and Coming Events.

PMID- 29816097
TI  - Stomach Movements before and after Gastro-Jejunostomy.

PMID- 29816096
TI  - Itching Eruptions in Babies.

PMID- 29816098
TI  - The League of Mercy.

PMID- 29816099
TI  - Some Causes of Haematuria.

PMID- 29816100
TI  - The Barnato Legacy.

PMID- 29816102
TI  - Specific Therapeutics.

PMID- 29816101
TI  - New Appliances & Things Medical.

PMID- 29816104
TI  - Operations on the Larynx and Trachea.

PMID- 29816103
TI  - The R.M.O. and outside Emergency Calls.

PMID- 29816105
TI  - Professional Relations between Dentists and Doctors.

PMID- 29816107
TI  - The Sixteenth International Medical Congress.

PMID- 29816106
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29816109
TI  - News and Coming Events.

PMID- 29816108
TI  - The Medical Register.

PMID- 29816110
TI  - Notes on Current Topics.

PMID- 29816111
TI  - The Nature of Malignant Testicular Tumours.

PMID- 29816112
TI  - Medical Opinion and Movement.

PMID- 29816113
TI  - Endowed Research.

PMID- 29816114
TI  - The Bar of Isis.

PMID- 29816115
TI  - English Hospitals and English Diplomas.

PMID- 29816116
TI  - New Appliances and Things Medical.

PMID- 29816117
TI  - Notes on Haemoptysis, with Illustrative Cases.-I.

PMID- 29816118
TI  - The Reflexes in Recent Hemiplegia.

PMID- 29816119
TI  - Splenic Enlargement in Infancy.

PMID- 29816120
TI  - Annotations.

PMID- 29816121
TI  - Diphtheria of the Skin.

PMID- 29816122
TI  - The Heating and Lighting of Hospital Wards.

PMID- 29816123
TI  - Ophthalmic Manifestations of Syphilis.

PMID- 29816124
TI  - Is Gastrostomy Justifiable?

PMID- 29816125
TI  - Pregnancy from a Legal Standpoint.

PMID- 29816126
TI  - Australia for the Sons of Professional Men.

PMID- 29816127
TI  - Better Training for Matrons.

PMID- 29816128
TI  - Advanced Life and Its Diseases.

PMID- 29816129
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29816130
TI  - A Lesson from New Zealand.

PMID- 29816131
TI  - A Mixed Afternoon in October.

PMID- 29816132
TI  - Raynaud's Disease-II.

PMID- 29816133
TI  - Practical Points.

PMID- 29816134
TI  - News and Coming Events.

PMID- 29816135
TI  - Unqualified Practice.

PMID- 29816136
TI  - Some Remarks on Hernia: VI. The Operative Treatment of a Strangulated Hernia
      (continued).

PMID- 29816137
TI  - Infusions of Digitalis in Heart Cases.

PMID- 29816138
TI  - Annotations.

PMID- 29816139
TI  - Lupus Vulgaris Treated by Direct Sunshine.

PMID- 29816140
TI  - Literary Notes.

PMID- 29816141
TI  - Graduate Study on the Continent-Austria.-IV: The Graduate Student at Vienna.

PMID- 29816142
TI  - On Tubal Moles.

PMID- 29816143
TI  - The Adulteration of Food.

PMID- 29816144
TI  - The Intercepting Trap on Its Trial.

PMID- 29816145
TI  - Medical Opinion and Movement.

PMID- 29816146
TI  - Stammering.

PMID- 29816147
TI  - Registration Difficulties-V.

PMID- 29816148
TI  - The Treatment of Psoriasis.

PMID- 29816149
TI  - New Appliances and Things Medical.

PMID- 29816150
TI  - Bacillus Typhosus in Sputum.

PMID- 29816151
TI  - Chronic Pharyngitis.

PMID- 29816152
TI  - Breach of Medical Etiquette.

PMID- 29816153
TI  - The Middlesex Hospital.

PMID- 29816154
TI  - Intermittent Claudication.

PMID- 29816155
TI  - Why the Register Must Fail from Incompleteness.

PMID- 29816156
TI  - The Research Hospital at Cambridge.

PMID- 29816157
TI  - The General Medical Council.

PMID- 29816158
TI  - News and Coming Events.

PMID- 29816159
TI  - The Sixteenth International Congress of Medicine.

PMID- 29816160
TI  - Amyotrophy in Syringomyelia.

PMID- 29816162
TI  - Medical Opinion and Movement.

PMID- 29816161
TI  - Convalescent, Home, Hornsea.

PMID- 29816163
TI  - The R.M.O. and Emergency Calls from outside.

PMID- 29816165
TI  - New Appliances & Things Medical.

PMID- 29816164
TI  - Aberrant Dyspepsias.

PMID- 29816167
TI  - The Value of Making a Rectal Examination.

PMID- 29816166
TI  - Doctors' Cars at the Motor Show.

PMID- 29816169
TI  - Some Notes on Phthisis.-II: Hoarseness in Pulmonary Tuberculosis.

PMID- 29816168
TI  - Lymphangioplasty.

PMID- 29816170
TI  - Prescriptions and Dispensing.

PMID- 29816171
TI  - Annotations.

PMID- 29816172
TI  - The Eye during Anaesthesia.

PMID- 29816174
TI  - Graduate Courses at the Infants Hospital.

PMID- 29816173
TI  - The Actual Technique of Tuberculo-Opsonic Estimation.

PMID- 29816175
TI  - Corporate Advertising.

PMID- 29816177
TI  - Laboratory Milk.

PMID- 29816176
TI  - The Doctor and Infectious Cases.

PMID- 29816178
TI  - Medical Opinion and Movement.

PMID- 29816179
TI  - Annotations.

PMID- 29816180
TI  - The Hospital Secretary.

PMID- 29816181
TI  - The Cervical Lymphatics in Phthisis.

PMID- 29816182
TI  - Some Chronic Joint Lesions.

PMID- 29816183
TI  - Better Training for Matrons.

PMID- 29816184
TI  - An Anti-Suicide Club.

PMID- 29816185
TI  - The Report of the Committee on the Inebriates Acts-I.

PMID- 29816186
TI  - Sexual Perversion-I.

PMID- 29816187
TI  - The Psychical Element in Some Functional Disturbances and Its Bearing upon
      Treatment.

PMID- 29816189
TI  - King Edward's Hospital Fund for London.

PMID- 29816188
TI  - News and Coming Events.

PMID- 29816190
TI  - The Immediate Treatment of Puerperal Sepsis-II.

PMID- 29816191
TI  - A Healthy Year.

PMID- 29816192
TI  - Diathesis.

PMID- 29816193
TI  - Some Current Topics.

PMID- 29816194
TI  - Graduate Study on the Continent-Austria.

PMID- 29816195
TI  - Thyroid Treatment of Psoriasis.

PMID- 29816196
TI  - Goosefoot Oil in the Treatment of Round Worms.

PMID- 29816197
TI  - Flies as Disease-Carriers.

PMID- 29816198
TI  - Christmas Appeal Number.

PMID- 29816199
TI  - The Research Hospital at Cambridge.

PMID- 29816200
TI  - Innocent Laryngeal Growths.-I.

PMID- 29816201
TI  - Some Notes on Phthisis-III: The General Appearance of the Patient.

PMID- 29816202
TI  - Two Consecutive Cases of Anencephalus.

PMID- 29816203
TI  - Empty Beds in London Hospitals?

PMID- 29816204
TI  - The Serum Treatment of Cerebro-Spinal Meningitis.

PMID- 29816205
TI  - Some Remarks on Hernia.

PMID- 29816206
TI  - Annotations.

PMID- 29816208
TI  - Medical Opinion and Movement.

PMID- 29816207
TI  - News and Coming Events.

PMID- 29816209
TI  - Orthopaedics in General Practice.-II.

PMID- 29816210
TI  - King Edward's Hospital Fund for London.

PMID- 29816211
TI  - Resolutions and Replies.

PMID- 29816212
TI  - Chloroform and Morphia in Maniacal Chorea.

PMID- 29816213
TI  - New Appliances and Things Medical.

PMID- 29816214
TI  - Buttermilk in Infant Feeding.

PMID- 29816215
TI  - The Preparation and After-Treatment of Abdominal Operations.

PMID- 29816216
TI  - Medical Qualifications.

PMID- 29816217
TI  - Practical Points in the Treatment of Rheumatism.

PMID- 29816218
TI  - Notes and News.

PMID- 29816219
TI  - Progress in Cancer.

PMID- 29816220
TI  - Sciatica.

PMID- 29816221
TI  - Annotations.

PMID- 29816223
TI  - The Hospital. Nursing Section.

PMID- 29816222
TI  - Water and Air.

PMID- 29816224
TI  - Progress in Psychiatry.

PMID- 29816225
TI  - Progress of Diseases of the Throat and Nose.

PMID- 29816226
TI  - Address in Surgery.

PMID- 29816227
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29816228
TI  - Glances at the Hospitals.

PMID- 29816229
TI  - Notes and News.

PMID- 29816230
TI  - The British Medical Association.

PMID- 29816231
TI  - Address in Medicine.

PMID- 29816232
TI  - Progress in Neurology.

PMID- 29816233
TI  - Metropolitan Hospital Sunday.

PMID- 29816234
TI  - Association for the Oral Instruction of the Deaf and Dumb.

PMID- 29816235
TI  - New Appliances and Things Medical.

PMID- 29816236
TI  - Cancer Research.

PMID- 29816237
TI  - M. Metchnikoff on the Future of Man.

PMID- 29816238
TI  - President's Address.

PMID- 29816239
TI  - Annotations.

PMID- 29816240
TI  - Modern Sociology.

PMID- 29816241
TI  - Tramways and Suburban Traffic.

PMID- 29816242
TI  - The Dreadnought Hospital in the Royal Albert Dock.

PMID- 29816243
TI  - Hospital Meetings.

PMID- 29816244
TI  - British Medical Association.

PMID- 29816246
TI  - Progress in Psychiatry.

PMID- 29816245
TI  - New Appliances and Things Medical.

PMID- 29816247
TI  - Progress in Cerebral Surgery.

PMID- 29816248
TI  - Uric Acid Accumulation in Gout.

PMID- 29816249
TI  - The Antitoxin Treatment of Hay Fever.

PMID- 29816250
TI  - Notes and News.

PMID- 29816251
TI  - Phenazone Poisoning.

PMID- 29816252
TI  - The Story of the Insane from Year to Year.

PMID- 29816253
TI  - Camberwell Infirmary.

PMID- 29816255
TI  - Embolism of the Central Artery of the Retina during the Injection of Paraffin.

PMID- 29816254
TI  - Progress of Surgery.

PMID- 29816256
TI  - St. Bartholomew's Hospital.

PMID- 29816257
TI  - Annotations.

PMID- 29816258
TI  - Mr. Jonathan Hutchinson, F.R.S.

PMID- 29816259
TI  - The Hospital. Nursing Section.

PMID- 29816260
TI  - Modern Bullet Wounds.

PMID- 29816261
TI  - The Hospital. Nursing Section.

PMID- 29816262
TI  - Glances at the Hospitals.

PMID- 29816263
TI  - The Cure of Hernia.

PMID- 29816264
TI  - Notes and News.

PMID- 29816265
TI  - Mountain-Sickness.

PMID- 29816266
TI  - The Law Relating to Medical Officers of Health (Outside Metropolis).-V.

PMID- 29816267
TI  - Progress in Cancer.

PMID- 29816268
TI  - Intra-Uterine Amputations.

PMID- 29816270
TI  - Progress in Surgery.

PMID- 29816269
TI  - Diseases of the Pancreas.

PMID- 29816272
TI  - The Story of the Insane from Year to Year.

PMID- 29816271
TI  - The Heel-Jerk.

PMID- 29816273
TI  - Progress in State Medicine.

PMID- 29816275
TI  - Annotations.

PMID- 29816274
TI  - Marriages, Births and Deaths.

PMID- 29816277
TI  - Sarcoma of the Testicle.

PMID- 29816276
TI  - A Medical Examination at the Surgeons' Company in 1789.

PMID- 29816278
TI  - "Mems." for Muddled Medicals.

PMID- 29816279
TI  - The Unqualified Assistant.

PMID- 29816280
TI  - The Medical Schools of London: Arrangements for the Session, 1889-90, with the
      Special Features and Cost of Curriculum at Each Institution.

PMID- 29816281
TI  - A Dean's Opinion: An Interview with Mr. A. Pearce Gould.

PMID- 29816282
TI  - The Student as the Nurse Sees Him.

PMID- 29816283
TI  - The Medical Mind and Conscience.

PMID- 29816284
TI  - Everybody's Page.

PMID- 29816285
TI  - Her Heart's Mistake: Chapter XXII.-A Year after.

PMID- 29816286
TI  - Notes and News.

PMID- 29816287
TI  - The Medical Freshman.

PMID- 29816288
TI  - Annotations.

PMID- 29816289
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816290
TI  - The Diagnosis of Cancer.

PMID- 29816291
TI  - Getting into Practice.

PMID- 29816292
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816293
TI  - The People.

PMID- 29816294
TI  - The Princess.

PMID- 29816296
TI  - The Prince.

PMID- 29816295
TI  - The Public Life of the Prince and Princess of Wales.

PMID- 29816297
TI  - Poem-The Royal Hand.

PMID- 29816298
TI  - The Clergy.

PMID- 29816299
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816300
TI  - A New Lease of Life.

PMID- 29816301
TI  - The "Bone of Contention".

PMID- 29816302
TI  - Special Notices for Hospital Sunday, 1889 A Year's Work in the Hospitals and
      Medical Charities of London.

PMID- 29816303
TI  - Notes and News.

PMID- 29816304
TI  - The Hospitals Association: Dr. Bristowe's Address.

PMID- 29816306
TI  - The Improvement of Idiots.

PMID- 29816305
TI  - Her Heart's Mistake.

PMID- 29816307
TI  - Everybody's Page.

PMID- 29816308
TI  - The Causation of Disease.

PMID- 29816309
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816310
TI  - Man and His Enemies.

PMID- 29816312
TI  - Annotations.

PMID- 29816311
TI  - A Successful Record.

PMID- 29816313
TI  - Tendon Grafting.

PMID- 29816314
TI  - Dangers of Raw Milk.

PMID- 29816315
TI  - Hydrophobia.

PMID- 29816316
TI  - Vital Statistics.

PMID- 29816317
TI  - Annotations.

PMID- 29816318
TI  - Hysterical Men.

PMID- 29816319
TI  - Catalepsy or Death.

PMID- 29816320
TI  - Man and His Enemies: "A Faint Heart".

PMID- 29816321
TI  - Bishop Temple Reports Progress and Asks for Further Help.

PMID- 29816322
TI  - Everybody's Page.

PMID- 29816323
TI  - With the Sick Children, Great Ormond-Street.

PMID- 29816324
TI  - The National Pension Fund for Nurses.

PMID- 29816325
TI  - Her Heart's Mistake.

PMID- 29816327
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816326
TI  - The Causation of Disease.-II.

PMID- 29816328
TI  - Notes and News.

PMID- 29816329
TI  - Heredity.

PMID- 29816330
TI  - Football Brutalities.

PMID- 29816332
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816331
TI  - Student Life in Edinburgh.

PMID- 29816333
TI  - Notes and News.

PMID- 29816334
TI  - The Countess of Dufferin's Fund: The National Association for Supplying Female
      Medical Aid to the Women of India.

PMID- 29816335
TI  - Man and His Enemies: The Wager of Battle.

PMID- 29816336
TI  - Everybody's Page.

PMID- 29816337
TI  - A Woman's Clothes-Philosophy.

PMID- 29816338
TI  - Annotations.

PMID- 29816339
TI  - The "Universal Review" for April.

PMID- 29816340
TI  - The Hospital Annual.

PMID- 29816341
TI  - For Women by Women.

PMID- 29816342
TI  - A Great American Hospital.

PMID- 29816344
TI  - Her Heart's Mistake.

PMID- 29816343
TI  - Lord Mayor Whitehead and the Working Classes.

PMID- 29816345
TI  - Mr. Gladstone and the Prince of Wales.

PMID- 29816347
TI  - Notes and News.

PMID- 29816346
TI  - Her Heart's Mistake.

PMID- 29816348
TI  - Man and His Enemies: Breaking to Harness.

PMID- 29816349
TI  - Vivisectors and Their Work.

PMID- 29816350
TI  - Variations in Hospital Expenditure.-I.

PMID- 29816351
TI  - Glances at the Insane in Other Lands.-VIII: Illinois.

PMID- 29816352
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816353
TI  - Practical Socialism.

PMID- 29816354
TI  - Everybody's Page.

PMID- 29816355
TI  - Annotations.

PMID- 29816356
TI  - Strychnia in Snakebite.

PMID- 29816357
TI  - The Enthusiasm of Humanity.

PMID- 29816358
TI  - Everybody's Page.

PMID- 29816359
TI  - About Specialists and Specialism.

PMID- 29816360
TI  - Notes and News.

PMID- 29816361
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816362
TI  - Her Heart's Mistake.

PMID- 29816363
TI  - Women Physicians at Clapham.

PMID- 29816364
TI  - The Amines Treatment of Sewage.

PMID- 29816365
TI  - Sickness.

PMID- 29816366
TI  - Fun at Fifty.

PMID- 29816367
TI  - Dr. Nansen's Message.

PMID- 29816368
TI  - The Story of the Insane from Year to Year: Asylum Reports.

PMID- 29816369
TI  - Annotations.

PMID- 29816370
TI  - The Deaf and the Dumb.

PMID- 29816371
TI  - Annotations.

PMID- 29816373
TI  - In the Surgery at Guy's.

PMID- 29816372
TI  - Her Heart's Mistake.

PMID- 29816374
TI  - A Simple Difficulty.

PMID- 29816375
TI  - St. John's Hospital for Diseases of the Skin.

PMID- 29816376
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816377
TI  - The Story of the Insane from Year to Year.

PMID- 29816378
TI  - Man and His Enemies.

PMID- 29816379
TI  - Hydrophobia.

PMID- 29816380
TI  - The Archbishop on the National Hospital for the Paralysed and Epileptic.

PMID- 29816381
TI  - An American Object Lesson.

PMID- 29816382
TI  - Notes and News.

PMID- 29816383
TI  - Everybody's Page.

PMID- 29816385
TI  - In Nature's School.

PMID- 29816384
TI  - Annotations.

PMID- 29816386
TI  - Country Holidays for Town Children.

PMID- 29816387
TI  - Her Heart's Mistake.

PMID- 29816388
TI  - The Church and the River.

PMID- 29816390
TI  - Pauper's Work.

PMID- 29816389
TI  - The Anti-Vaccinators and the Royal Commission.

PMID- 29816391
TI  - Metropolitan Association for Befriending Young Servants.

PMID- 29816392
TI  - The Physician as Naturalist.

PMID- 29816393
TI  - Everybody's Page.

PMID- 29816394
TI  - Notes and News.

PMID- 29816395
TI  - Cows' Milk and Consumption.

PMID- 29816396
TI  - Among Soldiers' Children.

PMID- 29816397
TI  - Sir Andrew Clark Taken to Task.

PMID- 29816398
TI  - Hydrophobia.

PMID- 29816399
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816400
TI  - The Suppression of Vivisection.

PMID- 29816401
TI  - Notes and News.

PMID- 29816402
TI  - Children's Country Holidays Fund.

PMID- 29816403
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816404
TI  - Education by Picnic.

PMID- 29816405
TI  - Overcrowded Cemeteries.

PMID- 29816406
TI  - The Tenderness of Christ.

PMID- 29816407
TI  - The Public Servants of the Future.

PMID- 29816408
TI  - Quiet Habits: Long Life.

PMID- 29816410
TI  - Mandragora.

PMID- 29816409
TI  - Hotels and Their Critics.

PMID- 29816411
TI  - The Boarding out of Pauper Children: II. Miss Mason's Report.

PMID- 29816412
TI  - Annotations.

PMID- 29816413
TI  - Left-Leggedness.

PMID- 29816414
TI  - Everybody's Page.

PMID- 29816415
TI  - Her Heart's Mistake: Chaps. xxiii and xxiv.

PMID- 29816416
TI  - Notes and News.

PMID- 29816417
TI  - Medicine Men of the World.

PMID- 29816418
TI  - The Making of New Features.

PMID- 29816419
TI  - What Must I Do to Get Well?

PMID- 29816420
TI  - Man and His Enemies: A Youth's Catechism of Health.

PMID- 29816421
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816422
TI  - Abstainers and Life Insurance.

PMID- 29816423
TI  - Neglected Men's Wards.

PMID- 29816424
TI  - Rocks Ahead.

PMID- 29816425
TI  - Twelve Hundred Miles under Difficulties.

PMID- 29816426
TI  - Annotations.

PMID- 29816427
TI  - Vivisectors and Their Work.

PMID- 29816428
TI  - Her Heart's Mistake.

PMID- 29816429
TI  - Everybody's Page.

PMID- 29816430
TI  - Life in Modern Asylums.

PMID- 29816431
TI  - Neutral Science.

PMID- 29816432
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816433
TI  - M. Zola on French Journalism and Its Health Results.

PMID- 29816435
TI  - Man and His Enemies: Invisible Companions.

PMID- 29816434
TI  - National Eye and Ear Infirmary, Dublin.

PMID- 29816437
TI  - Everybody's Page.

PMID- 29816436
TI  - Another Cancer Cure.

PMID- 29816438
TI  - The Working Classes and the Hospitals.

PMID- 29816440
TI  - The New Electric Tramcars.

PMID- 29816439
TI  - Her Heart's Mistake.

PMID- 29816441
TI  - Annotations.

PMID- 29816442
TI  - Father Damien.-A Life Given to the Lepers.

PMID- 29816443
TI  - Notes and News.

PMID- 29816444
TI  - Scrofulus Glands.

PMID- 29816445
TI  - The Donegal Fund.

PMID- 29816446
TI  - Hospitals and Their Expenditure.

PMID- 29816447
TI  - A Lung Cavity Opened Surgically.

PMID- 29816449
TI  - Prize Day at the London.

PMID- 29816448
TI  - Should Out-Patients Pay?

PMID- 29816450
TI  - Her Heart's Mistake.

PMID- 29816451
TI  - Everybody's Page.

PMID- 29816452
TI  - A Physiological Sunday.

PMID- 29816453
TI  - Notes and News.

PMID- 29816454
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816455
TI  - At the Royal Westminster Ophthalmic Hospital.

PMID- 29816456
TI  - In Nature's School.

PMID- 29816457
TI  - Leprosy in England.

PMID- 29816459
TI  - Hospitals without Medical Schools: Unconsidered Trifles.

PMID- 29816458
TI  - English Hotels and Their Critics.

PMID- 29816460
TI  - Annotations.

PMID- 29816461
TI  - English Hotels and Their Critics.

PMID- 29816462
TI  - A Street Ambulance Service for London.

PMID- 29816463
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816464
TI  - Everybody's Page.

PMID- 29816465
TI  - How to Give Medicine to Children.

PMID- 29816466
TI  - Opium and Its Votaries.

PMID- 29816467
TI  - Annotations.

PMID- 29816468
TI  - Examinations in Elementary Schools.

PMID- 29816469
TI  - Abstainers and Life Insurance.

PMID- 29816470
TI  - Vivisectors and Their Work.

PMID- 29816471
TI  - Man and His Enemies: The "Pinafore" Period.

PMID- 29816472
TI  - Her Heart's Mistake.

PMID- 29816474
TI  - Procursive Epilepsy.

PMID- 29816473
TI  - Notes and News.

PMID- 29816475
TI  - A Snakebite Cured.

PMID- 29816476
TI  - Notes and News.

PMID- 29816477
TI  - Her Heart's Mistake.

PMID- 29816478
TI  - Everybody's Page.

PMID- 29816479
TI  - A Lay of Ye Ancient Order of St. John of Jerusalem.

PMID- 29816480
TI  - Some Preachers and Subjects for Hospital Sunday.

PMID- 29816481
TI  - A Saturday Night at the London Hospital.

PMID- 29816483
TI  - Is Leprosy Infectious?

PMID- 29816482
TI  - In Nature's School.

PMID- 29816484
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816485
TI  - Sighing for His Mother.

PMID- 29816486
TI  - Annotations.

PMID- 29816488
TI  - Hospital Sunday Fund: Sir Andrew Clark Pleads for the Hospitals.

PMID- 29816487
TI  - Congregations and Collections.

PMID- 29816489
TI  - The Plans and Purposes of the Johns Hopkins Hospital.-I : Instructions and
      Cardinal Principles.

PMID- 29816491
TI  - In Nature's School.

PMID- 29816490
TI  - Her Heart's Mistake.

PMID- 29816492
TI  - The Maybrick Case: Lawyers v. Doctors.

PMID- 29816493
TI  - Notes and News.

PMID- 29816494
TI  - Everybody's Page.

PMID- 29816496
TI  - Annotations.

PMID- 29816495
TI  - Children's Country Holidays Fund.

PMID- 29816497
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816498
TI  - The Nursing in Fever Hospitals.

PMID- 29816499
TI  - The Love of Man to Man.

PMID- 29816500
TI  - On Some Points Connected with Cholera: I. Its Definition and Symptoms.

PMID- 29816501
TI  - The Story of the Insane from Year to Year.

PMID- 29816502
TI  - Foreign Bodies in Bronchial Tubes.

PMID- 29816503
TI  - The London Hospital and the National Pension Fund for Nurses.

PMID- 29816504
TI  - What Should the Deaf Do?

PMID- 29816505
TI  - Everybody's Page.

PMID- 29816506
TI  - Dr. Richardson, F.R.S., as a Novelist.

PMID- 29816507
TI  - The "Doctor's" Dictum Questioned.

PMID- 29816509
TI  - On Some Points Connected with Cholera: II. Some Theories Examined.

PMID- 29816508
TI  - A Physiological Study.

PMID- 29816511
TI  - Annotations.

PMID- 29816510
TI  - Wanted, More Howards.

PMID- 29816512
TI  - A Doctor's Vision.

PMID- 29816513
TI  - In Nature's School.

PMID- 29816514
TI  - A Pasteur Case.

PMID- 29816516
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816515
TI  - Everybody's Page.

PMID- 29816518
TI  - Notes and News.

PMID- 29816517
TI  - Notes and News.

PMID- 29816519
TI  - The Plans and Purposes of the Johns Hopkins Hospital: II. Cardinal Principles.

PMID- 29816520
TI  - Torturing and Starving Fish.

PMID- 29816521
TI  - Her Heart's Mistake: Chap. xix.

PMID- 29816522
TI  - Nightmare.

PMID- 29816523
TI  - The Lessons Taught by Suffering.

PMID- 29816524
TI  - A Steak-Pie Story.

PMID- 29816525
TI  - What Will Trained Nurses Gain by Joining the British Nurses' Association?

PMID- 29816526
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816527
TI  - In Nature's School.

PMID- 29816529
TI  - Annotations.

PMID- 29816528
TI  - The Story of the Insane from Year to Year.

PMID- 29816530
TI  - Is "High" Game Poisonous?

PMID- 29816531
TI  - Mrs. Gladstone's Home in Epping Forest.

PMID- 29816532
TI  - Her Heart's Mistake.

PMID- 29816533
TI  - The National Hospital for the Paralysed and Epileptic.

PMID- 29816534
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816535
TI  - The Causation of Disease.

PMID- 29816536
TI  - Annotations.

PMID- 29816537
TI  - Everybody's Page.

PMID- 29816538
TI  - A Stone in the Kidney.

PMID- 29816539
TI  - Her Heart's Mistake.

PMID- 29816540
TI  - Successful Disinfection.

PMID- 29816541
TI  - Medicine Men of the World.-II.

PMID- 29816542
TI  - Man and His Enemies: Barriers against Marriage.

PMID- 29816543
TI  - A Good Friday Concert at the Edinburgh Castle.

PMID- 29816544
TI  - Life in Modern Asylums.-II.

PMID- 29816545
TI  - The House of Lords and the Hospitals.

PMID- 29816546
TI  - Notes and News.

PMID- 29816547
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816548
TI  - Notes and News.

PMID- 29816549
TI  - Children's Country Holidays Fund.

PMID- 29816550
TI  - The Story of the Insane from Year to Year.

PMID- 29816551
TI  - Crime and Criminals.

PMID- 29816552
TI  - Annotations.

PMID- 29816553
TI  - Antiseptic Dressings.

PMID- 29816555
TI  - The Love of Man to God.

PMID- 29816554
TI  - Everybody's Page.

PMID- 29816556
TI  - Bacterial Diarrhcea at Leicester.

PMID- 29816557
TI  - "Squint" and Spectacles.

PMID- 29816558
TI  - In Nature's School.

PMID- 29816560
TI  - Our Poorer Neighbours: How to Provide for the Winter's Distress.

PMID- 29816559
TI  - Her Heart's Mistake.

PMID- 29816561
TI  - Doctors as Policemen.

PMID- 29816562
TI  - Jenner and Vaccination.

PMID- 29816563
TI  - Summer Diarrhoea and Cholera.

PMID- 29816564
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816565
TI  - Her Heart's Mistake.

PMID- 29816566
TI  - About Chemical Formulae.

PMID- 29816567
TI  - Annotations.

PMID- 29816568
TI  - The Throat Department at St. Mary's Hospital.

PMID- 29816569
TI  - Flitwick Water.

PMID- 29816570
TI  - The School of Medicine for Women.

PMID- 29816571
TI  - Everybody's Page.

PMID- 29816573
TI  - Notes and News.

PMID- 29816572
TI  - The British Nurses' Association: An Argument and a Warning.

PMID- 29816574
TI  - In Nature's School.

PMID- 29816575
TI  - The Scarlet Letter.

PMID- 29816576
TI  - A Public Medical Service for England.

PMID- 29816577
TI  - Palmistry.

PMID- 29816578
TI  - The Love of God to Man.

PMID- 29816580
TI  - Lord Rosebery's Work.

PMID- 29816579
TI  - Everybody's Page.

PMID- 29816582
TI  - Particulars of the Awards for 1889.

PMID- 29816581
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816583
TI  - Her Heart's Mistake.

PMID- 29816585
TI  - The Story of the Insane from Year to Year.

PMID- 29816584
TI  - The Hospitals of London.

PMID- 29816587
TI  - Awards and Criticisms.

PMID- 29816586
TI  - Earth Voices.

PMID- 29816588
TI  - Annotations.

PMID- 29816589
TI  - In Nature's School.

PMID- 29816590
TI  - In a Hospital.

PMID- 29816592
TI  - Notes and News.

PMID- 29816591
TI  - Out-Patients at St. Thomas's.

PMID- 29816593
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816594
TI  - Everybody's Page.

PMID- 29816595
TI  - In Nature's School.

PMID- 29816596
TI  - Florence Nightingale.

PMID- 29816597
TI  - Her Heart's Mistake.

PMID- 29816598
TI  - Notes and News.

PMID- 29816599
TI  - A Protest against Pasteurism.

PMID- 29816600
TI  - The Story of the Insane from Year to Year.

PMID- 29816601
TI  - Sea-Sickness.

PMID- 29816602
TI  - The Doctor's Critic Examined.

PMID- 29816603
TI  - Two Famous Doctors.

PMID- 29816604
TI  - Annotations.

PMID- 29816605
TI  - Medical Courtship.

PMID- 29816606
TI  - Daises and Buttercups.

PMID- 29816607
TI  - The Plans and Purposes of the Johns Hopkins Hospital: III. A Training School for
      Nurses.

PMID- 29816608
TI  - The Story of the Insane from Year to Year.

PMID- 29816609
TI  - Children and Creeds.

PMID- 29816610
TI  - Annotations.

PMID- 29816612
TI  - The Boarding out of Pauper Children: I. The System Itself.

PMID- 29816611
TI  - Other Lessons of Sickness.

PMID- 29816613
TI  - Notes and News.

PMID- 29816614
TI  - On Some Points Connected with Cholera: A Modern Theory.

PMID- 29816616
TI  - In Nature's School.

PMID- 29816615
TI  - Out-Patients at the Brompton Hospital.

PMID- 29816617
TI  - Her Heart's Mistake: Chapter XX.

PMID- 29816618
TI  - Everybody's Page.

PMID- 29816619
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816620
TI  - Curiosities of Brain and Nerve.

PMID- 29816621
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29816622
TI  - The Plans and Purposes of the Johns Hopkins Hospital: IV. The Hospital and
      Medical Education.

PMID- 29816623
TI  - Awakening.

PMID- 29816624
TI  - Everybody's Page.

PMID- 29816625
TI  - The Boarding out of Pauper Children: I. The System Itself.

PMID- 29816626
TI  - Out-Patients at St. Bartholomew's.

PMID- 29816627
TI  - Her Heart's Mistake: Chap. xxi.

PMID- 29816628
TI  - In Nature's School.

PMID- 29816629
TI  - Originality of Method.

PMID- 29816630
TI  - The Pleasures of Imagination Defended.

PMID- 29816631
TI  - Notes and News.

PMID- 29816632
TI  - The Story of the Insane from Year to Year.

PMID- 29816633
TI  - Children's Country Holidays Fund.

PMID- 29816634
TI  - On Some Points Connected with Cholera.

PMID- 29816635
TI  - Annotations.

PMID- 29816636
TI  - Beef-Tea and How to Make It.

PMID- 29816638
TI  - Progress in Surgery.

PMID- 29816637
TI  - Wounds of the Peritoneum.

PMID- 29816639
TI  - Guaiacol in Phthisis.

PMID- 29816640
TI  - New Appliances and Things Medical.

PMID- 29816641
TI  - An Electrical "Hospital"??

PMID- 29816642
TI  - Progress in Ophthalmology.

PMID- 29816643
TI  - Notes and News.

PMID- 29816644
TI  - Prison Administration and the Training of Officials.-IV.

PMID- 29816645
TI  - OEsophageal Pouch.

PMID- 29816646
TI  - Osmic Acid in Neuralgia.

PMID- 29816647
TI  - Annotations.

PMID- 29816648
TI  - On Ganglion, Simple and Compound.

PMID- 29816650
TI  - The Sanitary Service.

PMID- 29816649
TI  - Outdoor Treatment of Consumption.

PMID- 29816651
TI  - Is a Small-Pox Hospital a Nuisance?

PMID- 29816652
TI  - Exercise in Heart Disease.

PMID- 29816653
TI  - The British Pharmacopoeia, 1898.

PMID- 29816655
TI  - Payment for Notification.

PMID- 29816654
TI  - The Medical Council and Midwives.

PMID- 29816656
TI  - Progress in Obstetrics.

PMID- 29816657
TI  - The Hospital. Nursing Mirror.

PMID- 29816658
TI  - Hospital Meetings, &C.

PMID- 29816659
TI  - Annotations.

PMID- 29816660
TI  - Economics of Philanthropy.

PMID- 29816661
TI  - School Boards and Medical Certificates.

PMID- 29816662
TI  - Hospital Meetings, &C.

PMID- 29816664
TI  - Prison Reform.

PMID- 29816663
TI  - Progress in Medicine.

PMID- 29816666
TI  - Chloroform Administration.

PMID- 29816665
TI  - The Story of the Insane from Year to Year.

PMID- 29816667
TI  - An Erroneous Diagnosis.

PMID- 29816669
TI  - The Hospital. Nursing Mirror.

PMID- 29816668
TI  - Medical Education and Charity.

PMID- 29816670
TI  - Yellow Fever.

PMID- 29816671
TI  - Tuberculosis in Cold-Blooded Animals.

PMID- 29816673
TI  - The Royal College of Surgeons of England.

PMID- 29816672
TI  - Molluscum Contagiosum: Its Relation to the Lower Animals.

PMID- 29816674
TI  - Anti-Streptococcic Serum.

PMID- 29816675
TI  - Notes and News.

PMID- 29816676
TI  - Progress in Surgery.

PMID- 29816677
TI  - The Disinfection of Excreta.

PMID- 29816678
TI  - On Ganglion, Simple and Compound.

PMID- 29816679
TI  - Annotations.

PMID- 29816680
TI  - New Appliances and Things Medical.

PMID- 29816681
TI  - Some Selected Cases of Amenorrhoea with Gross Lesion.

PMID- 29816683
TI  - Notes.

PMID- 29816682
TI  - Hospital Meetings, &C.

PMID- 29816684
TI  - Notes and News.

PMID- 29816685
TI  - A Question of Privilege.

PMID- 29816686
TI  - Progress in Medicine.

PMID- 29816688
TI  - Progress in Surgery.

PMID- 29816687
TI  - The Metropolitan Press and the Hospitals.

PMID- 29816690
TI  - Progress in Obstetrics.

PMID- 29816689
TI  - The Midwives' Registration Bill.

PMID- 29816691
TI  - Vaccination by Private Practitioners.

PMID- 29816692
TI  - The Treatment of Acute Inflammatory Disease of the Heart.

PMID- 29816693
TI  - The Hospital. Nursing Mirror.

PMID- 29816694
TI  - Prison Administration and the Training of Officials.-III.

PMID- 29816695
TI  - Progress in Medicine.

PMID- 29816696
TI  - The Queen's Jubilee Hospital.

PMID- 29816697
TI  - Sterilisation of Surgical Instruments by Formaldehyde.

PMID- 29816699
TI  - Technique: A Word to Students.

PMID- 29816698
TI  - Compounding a Felony!

PMID- 29816700
TI  - Operations on the Liver.

PMID- 29816701
TI  - Annotations.

PMID- 29816702
TI  - Payment for Notification.

PMID- 29816703
TI  - The Middlesbrough Epidemic.

PMID- 29816704
TI  - The Workmen's Compensation Act.

PMID- 29816705
TI  - Enucleation or Hysterectomy.

PMID- 29816706
TI  - "Splicing" the Urethra.

PMID- 29816707
TI  - Prison Administration and the Training of Officials.-V.

PMID- 29816708
TI  - The Hospital. Nursing Mirror.

PMID- 29816709
TI  - The Law as to Death Certificates.

PMID- 29816710
TI  - Notes and News.

PMID- 29816711
TI  - Hospital Meetings, &C.

PMID- 29816712
TI  - Some Legal Points in Reference to Criminal Abortion.

PMID- 29816713
TI  - The Care of the Feet.

PMID- 29816714
TI  - Hospital Administration.

PMID- 29816715
TI  - Coats, Bags, and Puerperal Fever.

PMID- 29816716
TI  - A School for the Study of Tropical Diseases.

PMID- 29816717
TI  - Progress in Neurology.

PMID- 29816718
TI  - Phthisis and Compression of the Lung.

PMID- 29816719
TI  - Charred Straw as a Surgical Dressing.

PMID- 29816721
TI  - Methods of Rescue Work.

PMID- 29816720
TI  - The Cause of Drunkenness among Women.

PMID- 29816722
TI  - Hospital Meetings, &C.

PMID- 29816723
TI  - New Appliances and Things Medical.

PMID- 29816725
TI  - Progress in Surgery.

PMID- 29816724
TI  - Annotations.

PMID- 29816726
TI  - The Legality of Unqualified Practice.

PMID- 29816728
TI  - The Hospital. Nursing Mirror.

PMID- 29816727
TI  - Notes and News.

PMID- 29816729
TI  - Progress in Surgery.

PMID- 29816730
TI  - Trephining for Apoplexy.

PMID- 29816731
TI  - Eucalyptus in Actinomycosis.

PMID- 29816732
TI  - Munyon's "Remedies".

PMID- 29816734
TI  - The Inebriates Bill.

PMID- 29816735
TI  - Annotations.

PMID- 29816736
TI  - New Appliances and Things Medical.

PMID- 29816738
TI  - Hospital Meetings, &C.

PMID- 29816737
TI  - A Clinical Lecture on Goitre.

PMID- 29816740
TI  - The Medical Council.

PMID- 29816739
TI  - Pneumonia and Broncho-Pneumonia.

PMID- 29816741
TI  - The Hospital. Nursing Mirror.

PMID- 29816742
TI  - Notes and News.

PMID- 29816743
TI  - The Alkalinity of the Blood in Gout.

PMID- 29816744
TI  - Medical Orthodoxy in the Far East.

PMID- 29816745
TI  - Periscope of Dermatology.

PMID- 29816747
TI  - Women Inspectors under the Factory Acts.

PMID- 29816746
TI  - The Nursing in Prison Infirmaries.

PMID- 29816748
TI  - Modern Operating Theatres.

PMID- 29816749
TI  - The Edinburgh Meeting.

PMID- 29816750
TI  - Public Bodies and Workmen's Dwellings.

PMID- 29816751
TI  - What Is Meant by "Open Air"?

PMID- 29816752
TI  - Progress in Surgery.

PMID- 29816753
TI  - The Hospital. Nursing Mirror.

PMID- 29816754
TI  - The Sins of Teetotalers.

PMID- 29816755
TI  - Perforation in Typhoid Fever.- Successful Operation.

PMID- 29816756
TI  - The British Medical Association, Edinburgh.

PMID- 29816757
TI  - Compulsory Vaccination.

PMID- 29816758
TI  - Classification in Board Schools.

PMID- 29816759
TI  - Progress in Medicine.

PMID- 29816760
TI  - Progress in Ophthalmology.

PMID- 29816762
TI  - Annotations.

PMID- 29816761
TI  - Prognosis in Insanity.

PMID- 29816763
TI  - Notes and News.

PMID- 29816764
TI  - Annotations.

PMID- 29816765
TI  - The Flora of Healing Wounds.

PMID- 29816766
TI  - Notes and News.

PMID- 29816767
TI  - A Word to Hospital Critics.

PMID- 29816769
TI  - The Mother in the Factory.-II.

PMID- 29816768
TI  - Operations on the Liver.

PMID- 29816771
TI  - Morphomania.

PMID- 29816770
TI  - A Three Miles' Walk with a Penetrating Wound of the Abdomen.

PMID- 29816772
TI  - Neurotics and Cardio-Vascular Neuroses.

PMID- 29816774
TI  - Progress in Medicine.

PMID- 29816773
TI  - The Out-Door Treatment of Phthisis at Cromer.

PMID- 29816775
TI  - On Three Cases of Deformity Resulting from Hip-Joint Disease.

PMID- 29816776
TI  - Progress in Ophthalmology.

PMID- 29816777
TI  - Hospital Fittings.

PMID- 29816779
TI  - Infantile Paralysis.

PMID- 29816778
TI  - New Appliances and Things Medical.

PMID- 29816780
TI  - The Hospital. Nursing Mirror.

PMID- 29816781
TI  - Hospital Meetings, &C.

PMID- 29816782
TI  - The Army Medical Department.

PMID- 29816783
TI  - Laryngeal Stridor.

PMID- 29816784
TI  - The Cry of the Children.

PMID- 29816785
TI  - Progress in Medicine.

PMID- 29816786
TI  - Annotations.

PMID- 29816787
TI  - Nurses for Board Schools.

PMID- 29816788
TI  - The Hospital. Nursing Mirror.

PMID- 29816789
TI  - Fracture of the Patella.

PMID- 29816790
TI  - The Leper Hospitals of the West Indies.

PMID- 29816791
TI  - Gunshot Wounds of the Abdomen.

PMID- 29816792
TI  - Hospital Meetings, &C.

PMID- 29816793
TI  - Notes and News.

PMID- 29816795
TI  - Iodoform Gauze in Ruptured Uterus.

PMID- 29816794
TI  - Ropner Convalescent Home, Stockton-On-Tees.

PMID- 29816796
TI  - Progress in Surgery.

PMID- 29816798
TI  - Progress in Neurology.

PMID- 29816797
TI  - Prognosis in Insanity.

PMID- 29816799
TI  - New Appliances and Things Medical.

PMID- 29816800
TI  - The Crusade against Tuberculosis.

PMID- 29816801
TI  - The Lock-Stitch in Surgery.

PMID- 29816802
TI  - Total Extirpation of the Stomach.

PMID- 29816803
TI  - Notes.

PMID- 29816805
TI  - Notes and News.

PMID- 29816804
TI  - The Hospital. Nursing Mirror.

PMID- 29816806
TI  - Economics of Philanthropy.

PMID- 29816807
TI  - Rate-Supported Hospitals.

PMID- 29816808
TI  - The Antiseptic Treatment of Typhoid Fever.

PMID- 29816809
TI  - Wounds by Small Projectiles.

PMID- 29816810
TI  - Hospital Meetings, &C.

PMID- 29816811
TI  - Progress in Medicine.

PMID- 29816812
TI  - Explosive Bullets.

PMID- 29816813
TI  - The Story of the Insane from Year to Year.

PMID- 29816814
TI  - Progress in Surgery.

PMID- 29816815
TI  - Infantile Umbilical Hernia-Its Causation, Symptoms, and Treatment.

PMID- 29816816
TI  - Homestead Law.

PMID- 29816817
TI  - Annotations.

PMID- 29816818
TI  - Street Noises.

PMID- 29816819
TI  - British Laryngological, Rhinological, and Otological Association.

PMID- 29816820
TI  - New Appliances and Things Medical.

PMID- 29816821
TI  - Tuberculous Disease of the Bladder.

PMID- 29816822
TI  - New Appliances and Things Medical.

PMID- 29816823
TI  - Saprophytic Pneumococci.

PMID- 29816824
TI  - Ladies and Tobacco.

PMID- 29816825
TI  - Private Fees in Public Hospitals.

PMID- 29816826
TI  - Progress in Surgery.

PMID- 29816828
TI  - Tropical Hygiene.

PMID- 29816827
TI  - Notes and News.

PMID- 29816829
TI  - Annotations.

PMID- 29816831
TI  - The Hospital. Nursing Mirror.

PMID- 29816830
TI  - On Certain Eye Complications That Occur during and after an Attack of Gonorrhoea.

PMID- 29816832
TI  - The Treatment of Prisoners.

PMID- 29816833
TI  - Hospital Construction.

PMID- 29816834
TI  - Progress in Medicine.

PMID- 29816835
TI  - Medical Attendance upon Servants.

PMID- 29816836
TI  - Mrs. Garrett Anderson and the Midwives.

PMID- 29816837
TI  - Hospital Meetings, &C.

PMID- 29816838
TI  - Co-Operative House Buying.

PMID- 29816839
TI  - Notes.

PMID- 29816840
TI  - The Control of Measles and Whooping-Cough.

PMID- 29816841
TI  - Progress in Ophthalmology.

PMID- 29816842
TI  - Progress in Obstetrics.

PMID- 29816843
TI  - A Clinical Lecture on Goitre.

PMID- 29816844
TI  - A Post-Graduate College for London.

PMID- 29816845
TI  - Progress in Surgery.

PMID- 29816846
TI  - Hospital Meetings, &C.

PMID- 29816847
TI  - The Preparation of Glycerinated Calf Lymph.

PMID- 29816848
TI  - Notes and News.

PMID- 29816850
TI  - Periscope of Dermatology.

PMID- 29816849
TI  - The Open-Air Treatment of Phthisis.

PMID- 29816851
TI  - Juvenile Reformatories.

PMID- 29816852
TI  - The Treatment of Tabes.

PMID- 29816853
TI  - Annotations.

PMID- 29816854
TI  - New Appliances and Things Medical.

PMID- 29816855
TI  - The Teaching of Elementary Science.

PMID- 29816857
TI  - The Laws of War Relating to the Wounded.

PMID- 29816856
TI  - London Smoke.

PMID- 29816859
TI  - Notes from Australia.

PMID- 29816858
TI  - The Hospital. Nursing Mirror.

PMID- 29816860
TI  - Notes.

PMID- 29816862
TI  - Mediaeval Remedies for the Plague.-II.

PMID- 29816861
TI  - Hints for the Treatment of Suddenly-Developed Insanity.

PMID- 29816863
TI  - Hygiene in the East and in the West.

PMID- 29816864
TI  - Hospital Meetings, &C.

PMID- 29816866
TI  - New Appliances and Things Medical.

PMID- 29816865
TI  - A Medical Mrs. Grundy.

PMID- 29816867
TI  - Notes and News.

PMID- 29816868
TI  - The County Council and Nuisances.

PMID- 29816869
TI  - Seasonal Variation in Disease.

PMID- 29816870
TI  - The Metropolitan Asylum Board.

PMID- 29816871
TI  - The Hospital. Nursing Mirror.

PMID- 29816872
TI  - Vegetables and Gout.

PMID- 29816873
TI  - Chloroform Anaesthesia.

PMID- 29816874
TI  - Progress in Medicine.

PMID- 29816876
TI  - The Title of Physician.

PMID- 29816875
TI  - Progress in Surgery.

PMID- 29816877
TI  - Annotations.

PMID- 29816878
TI  - The Bicycle in Surgery.

PMID- 29816879
TI  - The Mansion House Dinner.

PMID- 29816880
TI  - Private Fees in Public Hospitals.

PMID- 29816881
TI  - Economics of Philanthropy.

PMID- 29816882
TI  - Progress in Medicine.

PMID- 29816883
TI  - An Action for Mal-Practice.

PMID- 29816885
TI  - Hospital Meetings, &C.

PMID- 29816884
TI  - The Relationship between Variola and Vaccinia.

PMID- 29816886
TI  - Annotations.

PMID- 29816887
TI  - Midwives' Registration Bill.

PMID- 29816888
TI  - A Clinical Lecture on Recent Advances in the Surgery of the Vermiform Appendix.

PMID- 29816889
TI  - The Influence of One Disease upon Another.

PMID- 29816890
TI  - Co-Operative Production.

PMID- 29816891
TI  - Foreign Bodies Left in the Abdomen after Operation.

PMID- 29816892
TI  - New Appliances and Things Medical.

PMID- 29816893
TI  - Progress in Surgery.

PMID- 29816894
TI  - Notes and News.

PMID- 29816895
TI  - The Hospital. Nursing Mirror.

PMID- 29816896
TI  - Cautions as to Health Resorts.

PMID- 29816897
TI  - Notes and News.

PMID- 29816898
TI  - The Unqualified Assistant.

PMID- 29816899
TI  - Medical, Surgical, and Hygienic Exhibition.

PMID- 29816900
TI  - Progress in Surgery.

PMID- 29816901
TI  - Editor's Letter-Box.

PMID- 29816903
TI  - The Treatment of Gout by Alkalies.

PMID- 29816902
TI  - Progress in Medicine.

PMID- 29816904
TI  - Notes.

PMID- 29816905
TI  - The Hospital. Nursing Mirror.

PMID- 29816906
TI  - The London University.

PMID- 29816907
TI  - Mediaeval Remedies for the Plague.

PMID- 29816908
TI  - Railway By-Laws.

PMID- 29816909
TI  - Hospital Meetings, &C.

PMID- 29816910
TI  - Hints for the Treatment of Suddenly-Developed Insanity.

PMID- 29816911
TI  - Oophorectomy in Cancer.

PMID- 29816912
TI  - Anytoles.

PMID- 29816913
TI  - Annotations.

PMID- 29816914
TI  - New Appliances and Things Medical.

PMID- 29816915
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29816917
TI  - The Plea of Insanity.

PMID- 29816916
TI  - Drink and Insanity.

PMID- 29816918
TI  - A Case of Intussusception.

PMID- 29816919
TI  - Notes and News.

PMID- 29816920
TI  - Progress in Surgery.

PMID- 29816922
TI  - Progress in Obstetrics and Gynaecology.

PMID- 29816921
TI  - The Hospital. Nursing Mirror.

PMID- 29816923
TI  - Annotations.

PMID- 29816924
TI  - Notification and Isolation.

PMID- 29816925
TI  - Small-Pox Hospital for Barnsley.

PMID- 29816927
TI  - Hospital Construction.

PMID- 29816926
TI  - Legislation and Public Health.

PMID- 29816928
TI  - Progress in Medicine.

PMID- 29816929
TI  - Uraemia.

PMID- 29816930
TI  - The Methods of Obtaining Asepsis in Operations in Private Practice.-I.

PMID- 29816932
TI  - New Appliances and Things Medical.

PMID- 29816931
TI  - The Hospital. Nursing Mirror.

PMID- 29816933
TI  - The Home Treatment of Disease.

PMID- 29816934
TI  - The Selection of Lives for Insurance.

PMID- 29816935
TI  - The Open-Air Treatment of Tuberculosis.

PMID- 29816936
TI  - Progress in Obstetrics and Gynaecology.

PMID- 29816937
TI  - The Vaccination Bill.

PMID- 29816939
TI  - The Actinic Opacity of London Air.

PMID- 29816938
TI  - On the Treatment of Diabetes.

PMID- 29816940
TI  - Annotations.

PMID- 29816941
TI  - Progress in Medicine.

PMID- 29816942
TI  - Notes and News.

PMID- 29816943
TI  - Abnormal Typhoid.

PMID- 29816944
TI  - Progress in Surgery.

PMID- 29816945
TI  - Lead as an Abortifacient.

PMID- 29816946
TI  - Fracture of the Patella.

PMID- 29816947
TI  - Queen Charlotte's Lying-In Hospital.

PMID- 29816948
TI  - The Marriage of the Unfit.

PMID- 29816949
TI  - Catheter Fever.

PMID- 29816951
TI  - The Hospital. Nursing Mirror.

PMID- 29816950
TI  - Notes on the Use of Bacteriological Methods of Diagnosis in Private Practice.-I.

PMID- 29816953
TI  - Sawdust Urinals.

PMID- 29816952
TI  - Notes and News.

PMID- 29816954
TI  - Hypnotism and Crime.

PMID- 29816955
TI  - Modes of Death in Punctured Wounds of the Heart.

PMID- 29816956
TI  - People's Banks.

PMID- 29816957
TI  - The Prince of Wales's Hospital Fund.

PMID- 29816958
TI  - Progress in Surgery.

PMID- 29816960
TI  - The Waste of Water.

PMID- 29816959
TI  - Notes from Australia.

PMID- 29816961
TI  - Progress in Medicine.

PMID- 29816962
TI  - The British Association.

PMID- 29816963
TI  - Annotations.

PMID- 29816965
TI  - Progress in Surgery.

PMID- 29816964
TI  - Medical Holidays.

PMID- 29816967
TI  - Hospital Construction.

PMID- 29816966
TI  - Holocaine.

PMID- 29816968
TI  - The Question of "Gears".

PMID- 29816969
TI  - The Re-Introduction of Small Pox.-II.

PMID- 29816970
TI  - Easily Satisfied!

PMID- 29816971
TI  - Arbroath Infirmary.

PMID- 29816972
TI  - New Appliances and Things Medical.

PMID- 29816973
TI  - The Pauper Sick in London.

PMID- 29816974
TI  - The Hospital. Nursing Mirror.

PMID- 29816976
TI  - Notes.

PMID- 29816975
TI  - Progress in Medicine.

PMID- 29816977
TI  - Annotations.

PMID- 29816978
TI  - Widal's Test for Typhoid.

PMID- 29816979
TI  - Rickety Curvatures of the Legs.

PMID- 29816980
TI  - Lead-Poisoning among Compositors.

PMID- 29816981
TI  - The Causes of Prolonged Infectivity in Scarlet Fever.

PMID- 29816982
TI  - Notes and News.

PMID- 29816983
TI  - Anti-Toxin and Post-Diphtherial Paralysis.

PMID- 29816984
TI  - Prolonged Retention of the Placenta.

PMID- 29816985
TI  - A Pin in the Rectum for Thirty Years.

PMID- 29816986
TI  - Drowned in Dust.

PMID- 29816987
TI  - Lady Visitors to Her Majesty's Prisons.

PMID- 29816988
TI  - The Hospital Sunday Fund.

PMID- 29816989
TI  - Charity Midwifery in London.

PMID- 29816990
TI  - Medical Aid in Time of War.

PMID- 29816991
TI  - Plymouth Borough Hospital.

PMID- 29816992
TI  - A Public Bacteriological Laboratory.

PMID- 29816993
TI  - Progress in Anaesthetics.

PMID- 29816994
TI  - Notes and News.

PMID- 29816995
TI  - Gastro-Jejunostomy.

PMID- 29816996
TI  - New Appliances and Things Medical.

PMID- 29816997
TI  - Aphasia and Testamentary Capacity.

PMID- 29816998
TI  - Progress in Medicine.

PMID- 29816999
TI  - The Hospital. Nursing Mirror.

PMID- 29817000
TI  - Annotations.

PMID- 29817001
TI  - Progress in Surgery.

PMID- 29817002
TI  - Hospital Administration.

PMID- 29817003
TI  - Return Cases of Scarlet Fever.

PMID- 29817005
TI  - Notes and News.

PMID- 29817004
TI  - Notes on the Use of Bacteriological Methods of Diagnosis in Private Practice.-II.

PMID- 29817006
TI  - The Inorganic Constituents of Vegetable Food.

PMID- 29817008
TI  - Progress in Surgery.

PMID- 29817007
TI  - Hospital Housekeeping.

PMID- 29817010
TI  - German Hospital Bath Houses.

PMID- 29817009
TI  - The Methods of Obtaining Asepsis in Operations in Private Practice.-II.

PMID- 29817011
TI  - Progress in Medicine.

PMID- 29817012
TI  - The Hospital. Nursing Mirror.

PMID- 29817013
TI  - The Physician in Perplexity.

PMID- 29817014
TI  - Progress in State Medicine.

PMID- 29817016
TI  - The Story of the Middlesex Hospital.

PMID- 29817017
TI  - The Nauheim Treatment of Heart Disease.

PMID- 29817018
TI  - Defective and Epileptic Children.

PMID- 29817019
TI  - Annotations.

PMID- 29817020
TI  - Felonious Physicians.

PMID- 29817021
TI  - Some Forms of Tertiary Syphilis.

PMID- 29817022
TI  - The Case of "Dr." Collins.

PMID- 29817023
TI  - Notes.

PMID- 29817024
TI  - Malpraxis.

PMID- 29817025
TI  - Medical Women.

PMID- 29817026
TI  - Hospital Administration.

PMID- 29817027
TI  - The Meaning and the Treatment of Dropsy.

PMID- 29817028
TI  - Progress in Medicine.

PMID- 29817029
TI  - Notes and News.

PMID- 29817030
TI  - The Leper Hospitals of the West Indies.

PMID- 29817031
TI  - Acute Dilatation of the Heart.

PMID- 29817033
TI  - The Hospital. Nursing Mirror.

PMID- 29817032
TI  - New Appliances and Things Medical.

PMID- 29817034
TI  - A Nursery of Typhus.

PMID- 29817035
TI  - Hospital Meetings, &C.

PMID- 29817036
TI  - Annotations.

PMID- 29817037
TI  - Progress in Neurology.

PMID- 29817038
TI  - Mr. Lawson Tait on Lumbar Colotomy.

PMID- 29817040
TI  - The Hospital. Nursing Mirror.

PMID- 29817039
TI  - Progress in Surgery.

PMID- 29817041
TI  - The Best in the World.

PMID- 29817042
TI  - Hospital Meetings, &C.

PMID- 29817043
TI  - Notes and News.

PMID- 29817044
TI  - Hospital Construction.

PMID- 29817045
TI  - Progress in Surgery.

PMID- 29817046
TI  - The Tonsil in Tuberculosis.

PMID- 29817047
TI  - The Action of Harrogate Water.

PMID- 29817048
TI  - The Leper Hospitals of the West Indies.

PMID- 29817049
TI  - Mediaeval Remedies for the Plague.-III.

PMID- 29817050
TI  - On the Question of Operative Interference in the Case of Fibroid Tumours of the
      Uterus.

PMID- 29817051
TI  - Annotations.

PMID- 29817052
TI  - Virulence and Non-Virulence.

PMID- 29817054
TI  - The Education of Dentists.

PMID- 29817053
TI  - The Press Bazaar in Aid of the London Hospital.

PMID- 29817055
TI  - Secondary Education.

PMID- 29817056
TI  - Typography and Eye Weariness.

PMID- 29817057
TI  - Progress in Neurology.

PMID- 29817058
TI  - New Appliances and Things Medical.

PMID- 29817059
TI  - Notes and News.

PMID- 29817060
TI  - The Choice of a Diploma.

PMID- 29817061
TI  - Annotations.

PMID- 29817062
TI  - New Appliances and Things Medical.

PMID- 29817063
TI  - The Choice of a Medical School.

PMID- 29817064
TI  - The Choice of a Profession.

PMID- 29817065
TI  - London Medical Schools.

PMID- 29817066
TI  - Other Hospitals at Which Clinical Instruction Is Given.

PMID- 29817067
TI  - Entry at a Medical School.

PMID- 29817068
TI  - Scottish Medical Schools.

PMID- 29817070
TI  - Progress in Medicine.

PMID- 29817069
TI  - Provincial Medical Schools.

PMID- 29817071
TI  - Irish Medical Schools.

PMID- 29817073
TI  - Progress in Surgery.

PMID- 29817072
TI  - The Hospital. Nursing Mirror.

PMID- 29817075
TI  - The Prosecution of Quacks.

PMID- 29817074
TI  - On Toxic Materials Released from the Faeces by Enemata and Poisoning the System.

PMID- 29817076
TI  - Hospital Housekeeping.

PMID- 29817077
TI  - Medical Degrees and Diplomas.

PMID- 29817078
TI  - A Military Hospital a Hundred Years Ago.

PMID- 29817079
TI  - Tropical Heart.

PMID- 29817080
TI  - Hospital Housekeeping.

PMID- 29817081
TI  - The Hospital. Nursing Mirror.

PMID- 29817083
TI  - Inoculation against Rinderpest.

PMID- 29817082
TI  - Casualty Room Failures.

PMID- 29817085
TI  - New Appliances and Things Medical.

PMID- 29817084
TI  - Progress in Medicine.

PMID- 29817087
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29817086
TI  - Medical Missions.

PMID- 29817088
TI  - Annotations.

PMID- 29817090
TI  - Notes and News.

PMID- 29817089
TI  - The Administration of Anaesthetics to Children.

PMID- 29817091
TI  - Complaints against Hospitals.

PMID- 29817093
TI  - Notes.

PMID- 29817092
TI  - The Crimino-Legal Responsibility of the Mentally Defective Psychologically
      Considered.

PMID- 29817094
TI  - The Re-Introduction of Small-Pox.-I.

PMID- 29817095
TI  - Progress in Surgery.

PMID- 29817096
TI  - Progress in Surgery.

PMID- 29817097
TI  - Diphtheria Anti-Toxin.

PMID- 29817098
TI  - Companies and Medical Practice.

PMID- 29817099
TI  - Progress in State Medicine.

PMID- 29817100
TI  - Latency of Renal Calculus.

PMID- 29817102
TI  - An Ear Replaced after Complete Severance.

PMID- 29817101
TI  - A Revolution in Gas Lighting.

PMID- 29817103
TI  - The Judicial Treatment of Infanticide.

PMID- 29817104
TI  - Hospital Meetings, &C.

PMID- 29817105
TI  - New Appliances and Things Medical.

PMID- 29817106
TI  - The St. Neots Murder.

PMID- 29817107
TI  - Annotations.

PMID- 29817108
TI  - The Hospital. Nursing Mirror.

PMID- 29817109
TI  - Economics of Philanthropy.

PMID- 29817111
TI  - Medical, Surgical, and Hygienic Exhibition.

PMID- 29817110
TI  - Modern Views about Consumption.

PMID- 29817112
TI  - A Clinical Lecture on Goitre.

PMID- 29817113
TI  - Nursing in Prisons.

PMID- 29817114
TI  - Notes and News.

PMID- 29817115
TI  - Special Hospital Sunday Supplement.

PMID- 29817116
TI  - Shell Wounds in the American Navy.

PMID- 29817117
TI  - Progress in Cancer.

PMID- 29817118
TI  - Lincolnshire Justices and Belgian Labour Colonies.

PMID- 29817119
TI  - Skipping as an Exercise.

PMID- 29817120
TI  - Annotations.

PMID- 29817121
TI  - Notes and News.

PMID- 29817122
TI  - The Hospital Library and Charities Bureau.

PMID- 29817124
TI  - Rheumatism and Gout.

PMID- 29817123
TI  - Clinical Lecture on Cancer of the Tongue.

PMID- 29817125
TI  - Congenital Malformations.

PMID- 29817126
TI  - Mixed Tumours of the Salivary Glands.

PMID- 29817128
TI  - Hospital Meetings.

PMID- 29817127
TI  - The Hospital. Nursing Section.

PMID- 29817129
TI  - King Edward's Hospital Fund for London.

PMID- 29817131
TI  - Progress in Genito-Urinary Surgery.

PMID- 29817130
TI  - British Institutions for the Care of the Inebriate.-VIII.

PMID- 29817132
TI  - The National Milk Supply.

PMID- 29817133
TI  - Hampstead General Hospital.

PMID- 29817134
TI  - The Cost of Provisions in Institutions.-V.

PMID- 29817135
TI  - Diseases of the Lungs.

PMID- 29817136
TI  - Diseases of the Stomach and Intestines.

PMID- 29817137
TI  - The Treatment of Dacryocystitis.

PMID- 29817138
TI  - Intra-Cranial and Extra-Cranial Haemorrhages in the New-Born.

PMID- 29817140
TI  - The Medical Uses of the X-Rays and Their Employment for These Purposes by
      Unqualified and Unskilled Persons.

PMID- 29817139
TI  - Annotations.

PMID- 29817141
TI  - The "Hospital Penny Fund."

PMID- 29817142
TI  - Old Age.

PMID- 29817143
TI  - New Offices and Nurses' Home at the Lambeth Infirmary, Brook Street.

PMID- 29817144
TI  - Intraspinal Cocainisation.

PMID- 29817145
TI  - Is Potassium Iodide a Specific in Lobar Pneumonia?

PMID- 29817146
TI  - Hospital Sunday Fund.

PMID- 29817147
TI  - Notes and News.

PMID- 29817149
TI  - Laryngeal Crepitus as a Sign of Pulmonary Tuberculosis.

PMID- 29817148
TI  - Hospital Meetings.

PMID- 29817150
TI  - The Hospital. Nursing Section.

PMID- 29817151
TI  - The Treatment of Inebriety by Atropine and the So-Called "Gold Cure."

PMID- 29817152
TI  - Orthopaedic Surgery.

PMID- 29817153
TI  - The Optical Society.

PMID- 29817155
TI  - Chorea and Taenia Solium.

PMID- 29817154
TI  - Progress in Genito-Urinary Surgery.

PMID- 29817157
TI  - King Edward VII.'s Hospital for Officers.

PMID- 29817156
TI  - Notes and News.

PMID- 29817158
TI  - Popular Medical Lectures.

PMID- 29817159
TI  - A Case of Pyometra Due to Plugging of the Cervix by a Fibroid Polypus.

PMID- 29817160
TI  - The Recognition of Nystagmus.

PMID- 29817161
TI  - The Cost of Provisions in Institutions.-III.

PMID- 29817162
TI  - Progress in Diseases of the Nervous System.

PMID- 29817163
TI  - The Story of the Insane from Year to Year.

PMID- 29817164
TI  - Preservation of Pathological or Other Specimens.

PMID- 29817165
TI  - Practical Departments.

PMID- 29817167
TI  - The Hospital. Nursing Section.

PMID- 29817166
TI  - British Health Stations.-II.

PMID- 29817168
TI  - Hospital Meetings.

PMID- 29817169
TI  - Albuminuria in the Apparently Healthy.

PMID- 29817170
TI  - Annotations.

PMID- 29817171
TI  - Physical Characters and Morbid Proclivities.

PMID- 29817172
TI  - Progress in Psychiatry.

PMID- 29817173
TI  - Diseases of the Lungs.

PMID- 29817174
TI  - Convalescent Hospital, Radcliffe.

PMID- 29817175
TI  - Hospital Meetings.

PMID- 29817176
TI  - A "Return" Case of Scarlet Fever.

PMID- 29817177
TI  - A New Sign of Basilar Meningitis.

PMID- 29817178
TI  - Progress in Orthopaedic Surgery.

PMID- 29817179
TI  - The Middlesex Hospital.

PMID- 29817180
TI  - Diver's and "Caisson" Disease.

PMID- 29817181
TI  - Notes and News.

PMID- 29817182
TI  - Pulsating Exophthalmos.

PMID- 29817183
TI  - The Hospital Library and Charities Bureau.

PMID- 29817184
TI  - Penetrating Wounds of the Abdomen.

PMID- 29817185
TI  - Progress in Psychiatry.

PMID- 29817186
TI  - The Dispensaries and Charitable Institutions of the Punjab.

PMID- 29817188
TI  - Inguinal Trusses.

PMID- 29817187
TI  - Annotations.

PMID- 29817189
TI  - The Hospital. Nursing Section.

PMID- 29817190
TI  - The Pathology of Asylum Dysentery.

PMID- 29817191
TI  - Dental Caries and Disease.

PMID- 29817192
TI  - Royal Edinburgh Hospital for Sick Children.

PMID- 29817193
TI  - Practical Departments.

PMID- 29817194
TI  - New Appliances and Things Medical.

PMID- 29817195
TI  - The "Goutte De Lait".

PMID- 29817196
TI  - The Hospital. Nursing Section.

PMID- 29817197
TI  - Infantile Mortality.

PMID- 29817198
TI  - The Treatment of Neurasthenia.

PMID- 29817199
TI  - A Case of Remarkable Vitality.

PMID- 29817200
TI  - The Melbourne Hospital.

PMID- 29817201
TI  - Overcrowding in the Medical Profession.

PMID- 29817202
TI  - On Food and Feeding.

PMID- 29817204
TI  - Lip Reading in the Seventeenth Century.

PMID- 29817203
TI  - Annotations.

PMID- 29817205
TI  - Genito-Urinary Surgery.

PMID- 29817206
TI  - Notes and News.

PMID- 29817207
TI  - Glances at the Hospitals.

PMID- 29817208
TI  - The Story of the Insane from Year to Year.

PMID- 29817209
TI  - Dental Deterioration.

PMID- 29817210
TI  - Neurology.

PMID- 29817211
TI  - Psychiatry.

PMID- 29817212
TI  - Coma in Diabetes Insipidus.

PMID- 29817213
TI  - The Hospital. Nursing Section.

PMID- 29817214
TI  - The Primary Seat of Infection in Tuberculosis.

PMID- 29817215
TI  - Congenital Hypertrophic Stenosis of the Pylorus.

PMID- 29817216
TI  - Carcinoma of the Colon.

PMID- 29817217
TI  - Anglo-American Hospital in Cairo.

PMID- 29817218
TI  - Progress in Dietetics.

PMID- 29817219
TI  - New Appliances and Things Medical.

PMID- 29817220
TI  - Practical Departments.

PMID- 29817221
TI  - Hospital Meetings.

PMID- 29817222
TI  - Hospitals and Dispensaries in Burma.

PMID- 29817223
TI  - Complications and Sequels of Prostatectomy.

PMID- 29817225
TI  - Adenoid Growths of the Nasopharynx: When and How to Operate.

PMID- 29817224
TI  - Progress in Orthopaedic Surgery.

PMID- 29817226
TI  - The Story of the Insane from Year to Year.

PMID- 29817227
TI  - Progress in Bacteriology.

PMID- 29817228
TI  - The Modern Diagnosis and Treatment of Diseases of the Stomach.

PMID- 29817229
TI  - Insurance against Surgical Operations.

PMID- 29817230
TI  - The Cost of Provisions in Institutions.-IV.

PMID- 29817231
TI  - Annotations.

PMID- 29817232
TI  - The Salicyl-Sulphonic Acid Test for Albumen.

PMID- 29817233
TI  - Notes and News.

PMID- 29817234
TI  - Physical Education in Elementary Schools.

PMID- 29817235
TI  - Small-Pox in Germany.

PMID- 29817236
TI  - The Treatment of Pneumococcic Infection.

PMID- 29817237
TI  - New Appliances and Things Medical.

PMID- 29817238
TI  - The Hospital. Nursing Section.

PMID- 29817239
TI  - The Cost of Provisions in Institutions.-II.

PMID- 29817240
TI  - Decapsulation of the Kidney in Nephritis.

PMID- 29817242
TI  - Lorenz's Operation.

PMID- 29817241
TI  - Progress in Psychiatry.

PMID- 29817243
TI  - Surgical Treatment of Hydrocephalus.

PMID- 29817244
TI  - "Opticians" and Sight Testing.

PMID- 29817245
TI  - Progress in Genito-Urinary Surgery.

PMID- 29817246
TI  - Annotations.

PMID- 29817247
TI  - Action of Artificial Digestive Fluids on Haemoglobin.

PMID- 29817249
TI  - Pneumatic Tourniquets.

PMID- 29817248
TI  - Progress in Cancer.

PMID- 29817250
TI  - Notes and News.

PMID- 29817251
TI  - The Insane in Workhouse Infirmaries.

PMID- 29817252
TI  - Hospital for Epilepsy at Maida Vale.

PMID- 29817253
TI  - The Hospital. Nursing Section.

PMID- 29817254
TI  - Neurology.

PMID- 29817255
TI  - Glances at the Hospitals.

PMID- 29817256
TI  - Arsenic and the Pharmacopoeia.

PMID- 29817258
TI  - Evidence in Coroners' Courts.

PMID- 29817257
TI  - Annotations.

PMID- 29817259
TI  - The Hospitals and Charitable Institutions of the United Provinces of India.

PMID- 29817260
TI  - Tuberculosis.

PMID- 29817261
TI  - The Story of the Insane from Year to Year.

PMID- 29817263
TI  - Notes and News.

PMID- 29817262
TI  - Psychiatry.

PMID- 29817265
TI  - Some Cases of Hemiplegia.

PMID- 29817264
TI  - The Treatment of Haemoptysis.

PMID- 29817266
TI  - Nurses' Home: Glasgow District Asylum at Gartloch.

PMID- 29817267
TI  - New Appliances and Things Medical.

PMID- 29817268
TI  - The Treatment of Chronic Nerve Injuries.

PMID- 29817269
TI  - Notes and News.

PMID- 29817270
TI  - Fevers.

PMID- 29817271
TI  - Aniline Dyes and Tumours of the Bladder.

PMID- 29817272
TI  - Neurology.

PMID- 29817273
TI  - The Medical Session.

PMID- 29817274
TI  - The Hospital. Nursing Section.

PMID- 29817275
TI  - Annotations.

PMID- 29817276
TI  - The Treatment of Fractures.

PMID- 29817277
TI  - Genito-Urinary Surgery.

PMID- 29817278
TI  - Glances at the Hospitals.

PMID- 29817279
TI  - Instruction in Tropical Medicine.

PMID- 29817280
TI  - Thyroid Grafting in Human Beings.

PMID- 29817281
TI  - Spread of Infectious Disease.-II.

PMID- 29817282
TI  - Syphilitic Disease of the Brain.

PMID- 29817283
TI  - Post-Graduation Study.

PMID- 29817284
TI  - Medical Qualifications.

PMID- 29817286
TI  - The Medical Schools.

PMID- 29817285
TI  - Medicine as a Profession.

PMID- 29817287
TI  - The Pathology and Treatment of the Herniae of Children.

PMID- 29817288
TI  - Annotations.

PMID- 29817290
TI  - Hospital Meetings.

PMID- 29817289
TI  - Predisposing and Precancerous Conditions of the Breast.

PMID- 29817291
TI  - New Appliances and Things Medical.

PMID- 29817293
TI  - Progress in Cancer.

PMID- 29817292
TI  - The Hospital Library and Charities Bureau.

PMID- 29817294
TI  - The Pathological Department of a Modern Hospital.

PMID- 29817295
TI  - Notes and News.

PMID- 29817296
TI  - British Institutions for the Care of the Inebriate.-IX.

PMID- 29817297
TI  - Progress in Genito-Urinary Surgery.

PMID- 29817298
TI  - On Treatment with Antituberculous Serum.

PMID- 29817299
TI  - Astigmatism and Its Consequences.

PMID- 29817300
TI  - The Cost of Provisions in Institutions.-I.

PMID- 29817301
TI  - The Hospital. Nursing Section.

PMID- 29817302
TI  - Bennett's Fracture.

PMID- 29817303
TI  - Rheumatism and Gout.

PMID- 29817304
TI  - Degeneracy and Marriage.

PMID- 29817305
TI  - The Hospital. Nursing Section.

PMID- 29817307
TI  - New Appliances and Things Medical.

PMID- 29817306
TI  - The Cost of Provisions in Institutions.-VII.

PMID- 29817308
TI  - The Fifteenth International Congress of Medicine.

PMID- 29817309
TI  - Invalid Children.

PMID- 29817310
TI  - Festival Dinner.

PMID- 29817312
TI  - Surgery.-Hernia.

PMID- 29817311
TI  - Annotations.

PMID- 29817313
TI  - Hospital Meetings.

PMID- 29817314
TI  - The Needs of the Modern Health Resort.

PMID- 29817315
TI  - The Medical, Surgical, and Hygienic Exhibition.

PMID- 29817317
TI  - Notes and News.

PMID- 29817316
TI  - Intra-Cranial Tumour: A Clinical Record and Commentary.

PMID- 29817319
TI  - Psychiatry.

PMID- 29817318
TI  - Medical Electricity.

PMID- 29817320
TI  - Dionine: A New Ocular Analgesic.

PMID- 29817321
TI  - The Royal Commission on Tuberculosis.

PMID- 29817322
TI  - A Model Hospital at the Cartwright Exhibition, Bradford.

PMID- 29817324
TI  - The Hospital. Nursing Section.

PMID- 29817323
TI  - The Surgical Treatment of Gastric Ulcer.

PMID- 29817325
TI  - Spread of Infectious Disease.-I.

PMID- 29817327
TI  - A New Method of Preserving Museum Specimens.

PMID- 29817326
TI  - The Fifteenth International Medical Congress.

PMID- 29817329
TI  - Hospital Meetings.

PMID- 29817328
TI  - Prevention of Sepsis in Nasal Operations.

PMID- 29817330
TI  - Medical Electricity.

PMID- 29817331
TI  - Notes and News.

PMID- 29817332
TI  - Insufficientia Pylori.

PMID- 29817333
TI  - New Pavilions at the Victoria Hospital for Consumption, Craigleith, Edinburgh.

PMID- 29817334
TI  - Diastolic Murmurs.

PMID- 29817335
TI  - The Effects of Alcohol, Nitro-Glycerine, and Amyl Nitrite in Shock.

PMID- 29817336
TI  - The Use of Purgatives in Abdominal Operations.

PMID- 29817337
TI  - Annotations.

PMID- 29817338
TI  - Road Sanitation.

PMID- 29817339
TI  - Psychiatry.

PMID- 29817340
TI  - The Story of the Insane from Year to Year.

PMID- 29817341
TI  - Tuberculosis.

PMID- 29817343
TI  - Visits to Private Asylums.

PMID- 29817342
TI  - Bolingbroke Hospital.

PMID- 29817344
TI  - The Early Diagnosis of Peritonitis.

PMID- 29817345
TI  - New Appliances and Things Medical.

PMID- 29817346
TI  - Glances at the Hospitals.

PMID- 29817348
TI  - The Toxic Effects of Urotropin.

PMID- 29817347
TI  - Remissions and Relapses in Insular Sclerosis.

PMID- 29817350
TI  - Tuberculosis.

PMID- 29817349
TI  - The Education of Defective Children.

PMID- 29817351
TI  - The Story of the Insane from Year to Year.

PMID- 29817352
TI  - Rheumatism in Childhood.

PMID- 29817353
TI  - Diffusion of Phthisis.

PMID- 29817354
TI  - Genito-Urinary Surgery.

PMID- 29817355
TI  - Glances at the Hospitals.

PMID- 29817356
TI  - The Treatment of Exophthalmic Goitre.

PMID- 29817357
TI  - Medicine and Pharmaceutical Research.

PMID- 29817358
TI  - Dr. Barnardo's Homes.

PMID- 29817359
TI  - Citrate of Sodium in Infant Feeding.

PMID- 29817360
TI  - The Hospital. Nursing Section.

PMID- 29817361
TI  - Annotations.

PMID- 29817362
TI  - The Distribution of Fat and Strychnine in Nux Vomica Seeds.

PMID- 29817363
TI  - Notes and News.

PMID- 29817364
TI  - The Bacteriology of Panophthalmitis.

PMID- 29817365
TI  - Visits to Private Asylums.

PMID- 29817366
TI  - Fevers.

PMID- 29817367
TI  - The Hospital. Nursing Section.

PMID- 29817368
TI  - Annotations.

PMID- 29817369
TI  - Treatment of Muco-Membranous Colitis.

PMID- 29817371
TI  - Livingstone College.

PMID- 29817370
TI  - International Congress on House Sanitation.

PMID- 29817372
TI  - Post-Operative Pneumonia.

PMID- 29817373
TI  - The Therapeutic Value of Kidney Extract.

PMID- 29817374
TI  - Abdominal Pain in Acute Rheumatism.

PMID- 29817375
TI  - Hemi-Hypertrophy of Limbs and Internal Organs.

PMID- 29817376
TI  - Surgery-Hernia.

PMID- 29817377
TI  - Hospital Sunday Sermons.

PMID- 29817378
TI  - The Cost of Provisions in Institutions.-IX.

PMID- 29817379
TI  - Notes and News.

PMID- 29817380
TI  - Precautions against Fire in Hospitals and Kindred Institutions.

PMID- 29817381
TI  - New Appliances and Things Medical.

PMID- 29817383
TI  - Muscular Atrophies in Joint Disease.

PMID- 29817382
TI  - The Prognosis of Postural Albuminuria.

PMID- 29817384
TI  - Consumption among Cornish Miners.

PMID- 29817385
TI  - The Registration of Medical Students.

PMID- 29817386
TI  - Psychiatry.

PMID- 29817387
TI  - State Medicine.

PMID- 29817388
TI  - Surgery of the Stomach.

PMID- 29817390
TI  - The Hospital. Nursing Section.

PMID- 29817389
TI  - Royal Waterloo Hospital for Children and Women.

PMID- 29817392
TI  - The Mental State in Myxoedema.

PMID- 29817391
TI  - Transposition of the Viscera.

PMID- 29817393
TI  - The Surgical Treatment of Abdominal Aneurysm.

PMID- 29817394
TI  - The Social Aspects of Illness.

PMID- 29817395
TI  - Pathological Conditions of the Urine.

PMID- 29817396
TI  - Surgery of the Peritoneum.

PMID- 29817397
TI  - The Interpretation of the Term "Extractum Belladonnae."

PMID- 29817399
TI  - The Sanatorium at Frimley for Brompton Consumption Hospital.

PMID- 29817398
TI  - Plan Competitions and the Difficulties of Architects: An Example.

PMID- 29817400
TI  - Annotations.

PMID- 29817401
TI  - Notes and News.

PMID- 29817402
TI  - Hospital Meetings.

PMID- 29817403
TI  - Secondary Parotitis.

PMID- 29817404
TI  - St. George's Hospital.

PMID- 29817405
TI  - New Appliances and Things Medical.

PMID- 29817407
TI  - Brachial Neuritis.

PMID- 29817406
TI  - North-Eastern Hospital for Children.

PMID- 29817408
TI  - The Cost of Provisions in Institutions.-X.

PMID- 29817409
TI  - New Appliances and Things Medical.

PMID- 29817410
TI  - Mr. Chamberlain at the Criterion.

PMID- 29817412
TI  - The City Sanatorium, Canterbury.

PMID- 29817411
TI  - The Hospital. Nursing Section.

PMID- 29817414
TI  - How to Sterilise Catgut.

PMID- 29817413
TI  - Notes and News.

PMID- 29817415
TI  - Annotations.

PMID- 29817416
TI  - What Is the Cure for Neurasthenia?

PMID- 29817417
TI  - St. George's Hospital in Danger.

PMID- 29817418
TI  - Surgery of the Pancreas and Spleen.

PMID- 29817419
TI  - Diseases of the Heart and Circulation.

PMID- 29817420
TI  - Bacteriology.

PMID- 29817421
TI  - Nurses in the Male Wards of Lunatic Asylums.

PMID- 29817422
TI  - The Tendon Jerks.

PMID- 29817423
TI  - St. Bartholomew's Hospital.

PMID- 29817424
TI  - Charitable Institutions of Victoria.

PMID- 29817425
TI  - The Treatment of Tabes Dorsalis.

PMID- 29817426
TI  - The Prophylactic Use of Morphine in Severe Cerebral Injuries: Cerebral
      Localisation of the Mental Faculties.

PMID- 29817427
TI  - The Cost of Provisions in Institutions.-XI.

PMID- 29817429
TI  - Fevers.

PMID- 29817428
TI  - The Story of the Insane from Year to Year.

PMID- 29817430
TI  - Cough and Its Significance.

PMID- 29817432
TI  - Glances at the Hospitals.

PMID- 29817431
TI  - Peripheral Neuritis with OEdema.

PMID- 29817433
TI  - Military Surgeons and Combatant Officers.

PMID- 29817434
TI  - The Cost of Provisions in Institutions.-XVI.

PMID- 29817435
TI  - Mr. Balfour on the Future of Our Race.

PMID- 29817436
TI  - Bacteriology.

PMID- 29817437
TI  - Neurology.

PMID- 29817438
TI  - Notes and News.

PMID- 29817439
TI  - Foreign Bodies in the Eye and Their Removal with the Electro-Magnet.

PMID- 29817440
TI  - Annotations.

PMID- 29817441
TI  - The Dispensaries of Assam.

PMID- 29817442
TI  - The Hospital. Nursing Section.

PMID- 29817443
TI  - Ear Sequelae of Acute Diseases.

PMID- 29817444
TI  - Visits to Private Asylums.

PMID- 29817445
TI  - Notes and News.

PMID- 29817446
TI  - Fevers.

PMID- 29817447
TI  - Surgery.

PMID- 29817448
TI  - The Hospital. Nursing Section.

PMID- 29817450
TI  - Annotations.

PMID- 29817449
TI  - The Metropolitan Asylums Board: Some Lost Opportunities.

PMID- 29817451
TI  - New Appliances and Things Medical.

PMID- 29817452
TI  - The Aix-La-Chapelle Treatment of Syphilis.

PMID- 29817453
TI  - Practical Departments.

PMID- 29817455
TI  - The Cost of Provisions in Institutions.-XV.

PMID- 29817454
TI  - Otology.

PMID- 29817456
TI  - Some Causes of Haematuria.

PMID- 29817457
TI  - Grouse Disease.

PMID- 29817458
TI  - Glances at the Hospitals.

PMID- 29817459
TI  - Urethral Stricture: Its Treatment and Prognosis.

PMID- 29817460
TI  - The Cost of Provisions in Institutions.-XII.

PMID- 29817461
TI  - Gynaecology.

PMID- 29817462
TI  - Hospitals and Opportunities.

PMID- 29817463
TI  - Hospital Meetings.

PMID- 29817464
TI  - Notes and News.

PMID- 29817465
TI  - Annotations.

PMID- 29817467
TI  - The Treatment of Inebriety by Atropine.

PMID- 29817466
TI  - Nurses in the Male Wards of Asylums for the Insane.

PMID- 29817468
TI  - Veronal: A New Hypnotic.

PMID- 29817469
TI  - The Hospital. Nursing Section.

PMID- 29817470
TI  - Tumours of the Breast.

PMID- 29817471
TI  - The Story of the Insane from Year to Year.

PMID- 29817472
TI  - Diseases of the Heart and Circulation.

PMID- 29817473
TI  - The Deterioration of Vision during School Life.

PMID- 29817474
TI  - Women and Whisky.

PMID- 29817475
TI  - Secondary Inflammations in Chronic Renal Disease.

PMID- 29817476
TI  - The Milk Supply of a Hospital: American Method of Sterilisation.

PMID- 29817477
TI  - Cancer Research.

PMID- 29817478
TI  - Bacteriology.

PMID- 29817479
TI  - The Hospital. Nursing Section.

PMID- 29817480
TI  - Some Pancreatic Lesions and Their Clinical Aspects.

PMID- 29817482
TI  - Hospital Meetings.

PMID- 29817481
TI  - Divers' or "Caisson" Disease.

PMID- 29817483
TI  - The Gerard Hospital, Monifieth, Forfarshire, N.B.

PMID- 29817485
TI  - Notes and News.

PMID- 29817484
TI  - Annotations.

PMID- 29817486
TI  - Members of the League of Mercy at Marlborough House.

PMID- 29817487
TI  - Accidents in the Country.

PMID- 29817488
TI  - The Surgeon's Responsibilities.

PMID- 29817489
TI  - Special Hospital Sunday Supplement.

PMID- 29817490
TI  - Hot-Water Injections Vice Nutrient Enemata.

PMID- 29817492
TI  - Human and Bovine Tuberculosis.

PMID- 29817491
TI  - Tuberculosis.

PMID- 29817493
TI  - Psychiatry.

PMID- 29817494
TI  - The Cost of Provisions in Institutions.-VIII.

PMID- 29817495
TI  - Hospital for Sick Children.

PMID- 29817497
TI  - Optic Neuritis in Chlorosis.

PMID- 29817496
TI  - A Note on Beef-Tea.

PMID- 29817498
TI  - The Therapeutics of the Ichthyol Compounds.

PMID- 29817499
TI  - Surgery.-Hernia.

PMID- 29817500
TI  - Some Unusual Complications of Measles.

PMID- 29817501
TI  - New Appliances and Things Medical.

PMID- 29817502
TI  - The Cost of Provisions in Institutions.-VI.

PMID- 29817503
TI  - "Costal Resistance" in Abdominal and Thoracic Diseases.

PMID- 29817504
TI  - The Manifestations of Hysteria.

PMID- 29817505
TI  - Practical Departments.

PMID- 29817507
TI  - Historical Sketch of Some of the London Hospitals.-III.

PMID- 29817506
TI  - Notes and News.

PMID- 29817509
TI  - Surgery.-Genito-Urinary.

PMID- 29817508
TI  - The Infants' Hospital, Denning Road, Hampstead.

PMID- 29817511
TI  - Hospital Meetings.

PMID- 29817510
TI  - The Hospital. Nursing Section.

PMID- 29817512
TI  - Lanfine Cottage Hospital for Incurable Cases of Consumption.

PMID- 29817513
TI  - Obesity and Its Treatment.

PMID- 29817514
TI  - Annotations.

PMID- 29817515
TI  - The Story of the Insane from Year to Year.

PMID- 29817516
TI  - Glances at the Hospitals.

PMID- 29817517
TI  - The Hospital Officers' Association.

PMID- 29817518
TI  - Gastric Dilatation and Tetany.

PMID- 29817519
TI  - Diseases of the Stomach and Intestines.

PMID- 29817521
TI  - Psychiatry.

PMID- 29817520
TI  - King Edward's Hospital Fund for London.

PMID- 29817522
TI  - Sociological Society.

PMID- 29817524
TI  - On Gastro-Jejunostomy for Pyloric Stenosis, Gastric Ulcer, and Some Other Non -
      Malignant Conditions.

PMID- 29817523
TI  - Caisson Disease and Vivisection.

PMID- 29817525
TI  - A Carlsbad Physician on the Treatment of Gout.

PMID- 29817526
TI  - Medical Education.

PMID- 29817527
TI  - Hospital Meetings.

PMID- 29817528
TI  - Nurses in the Male Wards of Public Asylums.

PMID- 29817529
TI  - Opening of Sanatorium and Convalescent Home, Heatherside, Camberley.

PMID- 29817530
TI  - Pancreatic Cysts.

PMID- 29817531
TI  - The Surgery of the Intestines.

PMID- 29817532
TI  - The New Sanatorium at Heatherside.

PMID- 29817533
TI  - Annotations.

PMID- 29817534
TI  - Pathological Conditions of the Urine.

PMID- 29817535
TI  - Earlswood Asylum.

PMID- 29817537
TI  - Distribution of Prizes at St. Thomas's Hospital Medical School.

PMID- 29817536
TI  - Notes and News.

PMID- 29817538
TI  - The Salt Tax in India.

PMID- 29817539
TI  - Sialolithiasis.

PMID- 29817540
TI  - Bacteriology.

PMID- 29817541
TI  - The Prevention of Rheumatic Endocarditis.

PMID- 29817542
TI  - The Heart in Acute Lobar Pneumonia.

PMID- 29817544
TI  - The Work of the Deptford Fund.

PMID- 29817543
TI  - The Royal Orthopaedic Hospital.

PMID- 29817545
TI  - The Hospital. Nursing Section.

PMID- 29817546
TI  - The Metropolitan Hospital.

PMID- 29817547
TI  - Medical Charities in Victoria.

PMID- 29817548
TI  - Scarborough Hospital for Infectious Diseases.

PMID- 29817549
TI  - Hydatid Disease of the Lung.

PMID- 29817550
TI  - Surgical or Traumatic Rheumatism.

PMID- 29817551
TI  - Glances at the Hospitals.

PMID- 29817552
TI  - New Appliances and Things Medical.

PMID- 29817553
TI  - Annotations.

PMID- 29817554
TI  - The Hospital. Nursing Section.

PMID- 29817555
TI  - Treatment of Puerperal Infection.

PMID- 29817556
TI  - An Examination of the Apparatus Proposed for the Quantitative Administration of
      Chloroform.

PMID- 29817557
TI  - Diphtheritic Paralysis.

PMID- 29817558
TI  - Surgery of the Liver and Bile Ducts.

PMID- 29817559
TI  - Notes and News.

PMID- 29817560
TI  - Cerebral Surgery.

PMID- 29817561
TI  - A Great Sanitarian.

PMID- 29817562
TI  - High Temperature and Hygiene in Dress.

PMID- 29817563
TI  - The Mental Effects of Alcohol.

PMID- 29817564
TI  - The Habit of Reticence.

PMID- 29817565
TI  - The Story of the Insane from Year to Year.

PMID- 29817566
TI  - Diseases of the Heart and Circulation.

PMID- 29817567
TI  - British Health Stations.-IV.

PMID- 29817568
TI  - The Hospital. Nursing Section.

PMID- 29817570
TI  - Medical Diplomates and University Degrees.

PMID- 29817569
TI  - The British Medical Association at Oxford.

PMID- 29817571
TI  - Glances at the Hospitals.

PMID- 29817572
TI  - Physical Deterioration.

PMID- 29817573
TI  - Hospital Meetings.

PMID- 29817574
TI  - New Appliances and Things Medical.

PMID- 29817575
TI  - Fevers.

PMID- 29817577
TI  - Annotations.

PMID- 29817576
TI  - Otology.

PMID- 29817579
TI  - Diseases of the Heart and Circulation.

PMID- 29817578
TI  - Notes and News.

PMID- 29817580
TI  - Practical Departments.

PMID- 29817581
TI  - The Cost of Provisions in Institutions.-XIV.

PMID- 29817582
TI  - The Bishop of London's Urgent Appeal on Behalf of His Diocesan Boys' Camps.

PMID- 29817583
TI  - Practical Departments.

PMID- 29817584
TI  - Diseases of the Heart and Circulation.

PMID- 29817585
TI  - Notes and News.

PMID- 29817586
TI  - Royal United Hospital, Bath.

PMID- 29817587
TI  - Surgery.

PMID- 29817589
TI  - Diseases of the Lungs.

PMID- 29817588
TI  - Annotations.

PMID- 29817590
TI  - Holidays and Holiday-Makers.

PMID- 29817591
TI  - Municipal Creches.

PMID- 29817592
TI  - Appendicitis.

PMID- 29817594
TI  - New Appliances and Things Medical.

PMID- 29817593
TI  - The Hospital. Nursing Section.

PMID- 29817595
TI  - Pneumothorax.

PMID- 29817596
TI  - Diphtheria of the Conjunctiva.

PMID- 29817597
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29817598
TI  - Syphilis of the Eye.

PMID- 29817599
TI  - The Treatment of Syphilis.

PMID- 29817600
TI  - Practical Departments.

PMID- 29817601
TI  - Primary Muscular Tuberculosis.

PMID- 29817603
TI  - The Sanitary Institute.

PMID- 29817602
TI  - Enlarged Prostate.

PMID- 29817604
TI  - Hospital Meetings.

PMID- 29817605
TI  - The Cost of Provisions in Institutions.-XIII.

PMID- 29817606
TI  - The Hospital. Nursing Section.

PMID- 29817607
TI  - Cerebral Surgery.

PMID- 29817608
TI  - New Appliances and Things Medical.

PMID- 29817610
TI  - Bradford Union Sanatorium for Pauper Consumptives at Eastby.

PMID- 29817609
TI  - Rheumatism as a Cause of Epistaxis in Children.

PMID- 29817612
TI  - Venesection in Opium Poisoning.

PMID- 29817611
TI  - The Treatment of Congenital Equinovarus during Early Infancy.

PMID- 29817613
TI  - The Failure of London County Council Administration.

PMID- 29817614
TI  - The Surgery of the Vermiform Appendix.

PMID- 29817615
TI  - Annotations.

PMID- 29817617
TI  - Physic at Oxford.

PMID- 29817616
TI  - The Treatment of Gonorrhoea and Gonorrhoeal Arthritis.

PMID- 29817618
TI  - Notes and News.

PMID- 29817619
TI  - A League of Mercy in the Colonies.

PMID- 29817620
TI  - Hygienic Education.

PMID- 29817621
TI  - Acute Thyroidism Following Curettage.

PMID- 29817622
TI  - Acute Balanitis Treated Locally with Ethyl Chloride.

PMID- 29817623
TI  - Diseases of the Heart and Circulation.

PMID- 29817624
TI  - Treatment of Vesical Calculus in Children.

PMID- 29817625
TI  - New Appliances and Things Medical.

PMID- 29817626
TI  - Diseases of Certain Glands.

PMID- 29817627
TI  - Hospital Meetings.

PMID- 29817628
TI  - Notes and News.

PMID- 29817630
TI  - Premature Burial.

PMID- 29817629
TI  - An Obscure Multiple Joint Disease of Childhood.

PMID- 29817631
TI  - The Causation of Peritonitis.

PMID- 29817632
TI  - Acute Lymphatic Leukaemias.

PMID- 29817633
TI  - Early Sequelae of Faucial Diphtheria and Their Treatment.

PMID- 29817634
TI  - Typhoid Fever at Lincoln.

PMID- 29817636
TI  - Glances at the Hospitals.

PMID- 29817635
TI  - The Hospital Library and Charities Bureau.

PMID- 29817637
TI  - The Hospital. Nursing Section.

PMID- 29817638
TI  - The Engineering Side of Hospital Work: V. Refuse Destructors and Disinfectors.

PMID- 29817639
TI  - Appendicitis up to Date.

PMID- 29817640
TI  - Diseases of the Kidney.

PMID- 29817641
TI  - Anaesthetics.

PMID- 29817642
TI  - Practical Departments.

PMID- 29817643
TI  - The Story of the Insane from Year to Year.

PMID- 29817644
TI  - Man versus the Microbe.

PMID- 29817645
TI  - Annotations.

PMID- 29817646
TI  - The Pains of Tabes Dorsalis.

PMID- 29817648
TI  - Hospital Meetings.

PMID- 29817647
TI  - Hospital Expenditure and Efficiency.

PMID- 29817649
TI  - Notes and News.

PMID- 29817650
TI  - Respiratory Diseases.

PMID- 29817651
TI  - Alcohol and Digestion.

PMID- 29817652
TI  - Diseases of Circulatory System.

PMID- 29817654
TI  - The Engineering Side of Hospital Work: VII. Disinfectors and Sterilisers.

PMID- 29817653
TI  - Congenital Hypertrophic Stenosis of the Pylorus.

PMID- 29817655
TI  - The Function of the Thyroid and Parathyroids.

PMID- 29817656
TI  - The Hospital Library and Charities Bureau.

PMID- 29817657
TI  - Convulsive Tic.

PMID- 29817658
TI  - The Hospital. Nursing Section.

PMID- 29817660
TI  - Annotations.

PMID- 29817659
TI  - The National Hospital.

PMID- 29817661
TI  - Neurology.

PMID- 29817662
TI  - Hospital Questions Which Press.

PMID- 29817663
TI  - Myasthenia Gravis.

PMID- 29817664
TI  - New Appliances and Things Medical.

PMID- 29817665
TI  - A Curiosity of Immunisation.

PMID- 29817666
TI  - Premature Burial.

PMID- 29817667
TI  - Hernia.

PMID- 29817668
TI  - Economy in Scottish Hospitals.

PMID- 29817669
TI  - Hospital Meetings.

PMID- 29817670
TI  - The Homeless Poor of London.

PMID- 29817671
TI  - Annotations.

PMID- 29817672
TI  - Diseases of Circulatory System.

PMID- 29817673
TI  - Septicaemia.

PMID- 29817674
TI  - On Shifting Percussion Dulness.

PMID- 29817675
TI  - Perforation of the Intestine in Typhoid Fever.

PMID- 29817676
TI  - The Hospital. Nursing Section.

PMID- 29817677
TI  - Diseases of the Kidney.

PMID- 29817678
TI  - Great Northern Central Hospital.

PMID- 29817679
TI  - Hospital Expenditure and Efficiency.

PMID- 29817680
TI  - The Royal Infirmary, Glasgow.

PMID- 29817681
TI  - Notes and News.

PMID- 29817682
TI  - The Dundee "Social Union".

PMID- 29817684
TI  - The Engineering Side of Hospital Work: VII. Disinfectors adn Sterilisers.

PMID- 29817683
TI  - Pneumococcal Arthritis.

PMID- 29817685
TI  - Respiratory Diseases.

PMID- 29817686
TI  - Intravesical Separation of the Urines.

PMID- 29817687
TI  - Annotations.

PMID- 29817688
TI  - Hospital Meetings.

PMID- 29817689
TI  - Notes and News.

PMID- 29817690
TI  - The Control of Hospital Expenditure with Efficiency.

PMID- 29817691
TI  - Diseases of the Kidney.

PMID- 29817692
TI  - The Hospital Library and Charities Bureau.

PMID- 29817694
TI  - Diseases of the Respiratory Organs.

PMID- 29817693
TI  - Iodine Bath Treatment of Empyema.

PMID- 29817695
TI  - British Medical Association.

PMID- 29817696
TI  - Surgery of the Intestines.

PMID- 29817698
TI  - Convalescent Homes.

PMID- 29817697
TI  - The Etiology of Carcinoma.

PMID- 29817699
TI  - The Engineering Side of Hospital Work: VI. Refuse, Destructors, or Incinerators.

PMID- 29817700
TI  - The Hospital. Nursing Section.

PMID- 29817702
TI  - The Infant at Birth.

PMID- 29817701
TI  - The Therapeutic Value of Relaxing Climates.

PMID- 29817703
TI  - The Treatment of Incipient Insanity.

PMID- 29817704
TI  - The Proposed Royal Society of Medicine.

PMID- 29817705
TI  - Hospital Control and Efficiency.

PMID- 29817706
TI  - The Treatment of Locomotor Ataxy.

PMID- 29817707
TI  - A Posterior Incision in Operations for Appendicitis.

PMID- 29817708
TI  - High-Frequency Currents and the Treatment of Sciatica.

PMID- 29817709
TI  - Surgical Operations in Private Practice: II. Compound Fracture and Psoas Abscess.

PMID- 29817710
TI  - Tottenham Hospital.

PMID- 29817711
TI  - Addenbrooke's Hospital, Cambridge.

PMID- 29817713
TI  - Hospitals and Medical Schools.

PMID- 29817712
TI  - Annotations.

PMID- 29817714
TI  - Diseases of the Pancreas.

PMID- 29817715
TI  - Shelters and Lodging Houses.

PMID- 29817717
TI  - Glances at the Hospitals.

PMID- 29817716
TI  - The Hospital Penny Fund.

PMID- 29817718
TI  - Medical Practitioners and Hospital Abuse.

PMID- 29817719
TI  - The Hospital. Nursing Section.

PMID- 29817720
TI  - Lord Kelvin at St. George's Hospital.

PMID- 29817721
TI  - Notes and News.

PMID- 29817723
TI  - Bacteriology.

PMID- 29817722
TI  - Some Ocular Paralyses.

PMID- 29817724
TI  - Separate Courts of Justice for Children.

PMID- 29817725
TI  - Neurology.

PMID- 29817727
TI  - Antivivisection Statistics.

PMID- 29817726
TI  - Traumatic Apoplexy.

PMID- 29817728
TI  - Diseases of the Respiratory System.

PMID- 29817729
TI  - The "Goutte De Lait".

PMID- 29817730
TI  - Neurology.

PMID- 29817731
TI  - Glances at the Hospitals.

PMID- 29817733
TI  - Some Rarer Forms of Nephritis.

PMID- 29817732
TI  - Regimental Homes.

PMID- 29817734
TI  - Argyrol in Ulcerative Colitis; the Vomiting of Enemata.

PMID- 29817735
TI  - The Story of the Insane from Year to Year.

PMID- 29817737
TI  - Ophthalmology.

PMID- 29817736
TI  - Bacteria in the Atmosphere.

PMID- 29817739
TI  - The Hospital. Nursing Section.

PMID- 29817738
TI  - Strychnine as an Evacuant.

PMID- 29817740
TI  - Anti-Vivisection Statistics.

PMID- 29817741
TI  - Notes and News.

PMID- 29817742
TI  - The Treatment of Rectal Prolapse by the Submucous Injection of Paraffin.

PMID- 29817743
TI  - Annotations.

PMID- 29817744
TI  - Practical Departments.

PMID- 29817745
TI  - Amaurosis and Retro-Bulbar Neuritis.

PMID- 29817746
TI  - New Appliances and Things Medical.

PMID- 29817747
TI  - The Conference on Tuberculosis.

PMID- 29817748
TI  - Forty-Sixth Annual Report of the Commissioners in Lunacy for Scotland.

PMID- 29817749
TI  - The Hospital. Nursing Section.

PMID- 29817750
TI  - The Small Hospitals and the Funds.

PMID- 29817751
TI  - Diseases of the Pancreas.

PMID- 29817753
TI  - Opening of New Jewish Wards at the London Hospital.

PMID- 29817752
TI  - Annotations.

PMID- 29817754
TI  - Syphilitic Synovitis in Children.

PMID- 29817755
TI  - New Home for Nurses at the Cancer Hospital, Fulham Road, S.w.

PMID- 29817756
TI  - Anti-Typhoid Inoculation.

PMID- 29817757
TI  - Psychiatry.

PMID- 29817758
TI  - Surgery of Bone.

PMID- 29817759
TI  - Vagrants and Disease.

PMID- 29817761
TI  - National Hospital for the Paralysed and Epileptic.

PMID- 29817760
TI  - Superheated Compressed Air and Comminuted Medicated Vapours in the Treatment of
      Diseases of the Respiratory Tract.

PMID- 29817762
TI  - Umbilical Hernia.

PMID- 29817763
TI  - Medical Practitioners and Hospital Abuse.

PMID- 29817764
TI  - Hospital Penny Fund.

PMID- 29817765
TI  - The Mechanism of Exophthalmos.

PMID- 29817766
TI  - Puerperal Eclampsia.

PMID- 29817767
TI  - The Salop Infirmary, Shrewsbury.

PMID- 29817768
TI  - Notes and News.

PMID- 29817769
TI  - Diet and Drugs in Diabetes.

PMID- 29817770
TI  - The Hospital. Nursing Section.

PMID- 29817772
TI  - A Suggested New Departure in Hospital Administration: II. The Chairman
      Superintendent.-Objections.

PMID- 29817771
TI  - Notes and News.

PMID- 29817773
TI  - Annotations.

PMID- 29817774
TI  - Psychiatry.

PMID- 29817775
TI  - The General Medical Council.

PMID- 29817776
TI  - Neurology.

PMID- 29817777
TI  - The Central Funds and Special Hospitals.

PMID- 29817778
TI  - Hospital Meetings.

PMID- 29817780
TI  - The Birth-Rate in New South Wales.

PMID- 29817779
TI  - Visits to Private Asylums.

PMID- 29817781
TI  - Prize-Giving at Charing Cross Hospital Medical School.

PMID- 29817782
TI  - Glances at the Hospitals.

PMID- 29817783
TI  - Surgical Operations in Private Practice: IV. The Preparation of Rooms and
      Instruments.

PMID- 29817784
TI  - Cerebral and Nerve Surgery.

PMID- 29817786
TI  - Glances at the Hospitals.

PMID- 29817785
TI  - Beri-Beri.

PMID- 29817788
TI  - Psychiatry.

PMID- 29817787
TI  - Diseases of the Colon.

PMID- 29817790
TI  - A Red Cross Society.

PMID- 29817789
TI  - Examinations in Tropical Medicine.

PMID- 29817791
TI  - Meeting of Clergy at the North-Eastern Hospital for Children, Hackney Road, E.

PMID- 29817792
TI  - Neurology.

PMID- 29817793
TI  - Internal Secretion and the Thyroid Gland.

PMID- 29817794
TI  - Notes and News.

PMID- 29817796
TI  - The Story of the Insane from Year to Year.

PMID- 29817795
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29817797
TI  - A Suggested New Departure in Hospital Administration: I. The Chairman
      Superintendent.-Advantages.

PMID- 29817798
TI  - The Hospital. Nursing Section.

PMID- 29817799
TI  - King Edward's Hospital Fund for London.

PMID- 29817800
TI  - Surgical Operations in Private Practice: III. Surgical Interference with the
      Pleural Cavity.

PMID- 29817801
TI  - Annotations.

PMID- 29817802
TI  - The Treatment of Pruritus Ani.

PMID- 29817804
TI  - The Hospital Funds and the Special Hospitals.

PMID- 29817803
TI  - National Hospital for the Paralysed and Epileptic.

PMID- 29817805
TI  - Glances at the Hospitals.

PMID- 29817806
TI  - Hospital Meetings.

PMID- 29817807
TI  - Proposed Emergency Hospital for Ilford.

PMID- 29817808
TI  - The Hospital. Nursing Section.

PMID- 29817810
TI  - Pneumococcus Peritonitis.

PMID- 29817809
TI  - Diseases of the Stomach and Intestines.

PMID- 29817812
TI  - Rats on Shipboard.

PMID- 29817811
TI  - The Control of the Inebriate.

PMID- 29817813
TI  - Obstetrics.

PMID- 29817814
TI  - New Appliances and Things Medical.

PMID- 29817815
TI  - Parotitis and Gastric Ulcer.

PMID- 29817816
TI  - Therapeutic Fasting in Enteric Fever.

PMID- 29817817
TI  - Surgical Operations in Private Practice: V. Varicose Veins.

PMID- 29817818
TI  - Annotations.

PMID- 29817819
TI  - Notes and News.

PMID- 29817821
TI  - Diabetes.

PMID- 29817820
TI  - Hospital Records and Medical Research.

PMID- 29817822
TI  - Hospitals and Medical Schools.

PMID- 29817823
TI  - St. Bartholomew's Hospital.

PMID- 29817825
TI  - Cancer Research.

PMID- 29817824
TI  - X-Rays as an Aid to Medical Diagnosis.

PMID- 29817826
TI  - Genito-Urinary Diseases.

PMID- 29817827
TI  - East London Medical Society and Hospital Abuse.

PMID- 29817828
TI  - Rheumatism and Gout.

PMID- 29817829
TI  - Pathological Research in London County Asylums.

PMID- 29817831
TI  - The Hospital. Nursing Section.

PMID- 29817830
TI  - Annotations.

PMID- 29817832
TI  - Epithelioma of the Tongue in Women.

PMID- 29817833
TI  - How St. Bartholomew's Hospital Can Be Saved.

PMID- 29817834
TI  - A Lecture on Albuminuria as a Complication of Pregnancy.

PMID- 29817835
TI  - Gross Cleanliness in Surgery.

PMID- 29817836
TI  - Philosophy and Medicine.

PMID- 29817837
TI  - Notes and News.

PMID- 29817838
TI  - The Distinction between Incomplete Fracture of the Neck of the Femur and
      Separation of the Epiphysis.

PMID- 29817839
TI  - Chorion-Epithelioma, Vesicular Mole, and Lutein Cysts.

PMID- 29817840
TI  - Lectures on the Feeding of Infants: I. Breast Feeding and Weaning.

PMID- 29817841
TI  - Hospital Meetings.

PMID- 29817842
TI  - Diabetes.

PMID- 29817844
TI  - Annotations.

PMID- 29817843
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29817845
TI  - The Hospital. Nursing Section.

PMID- 29817846
TI  - King Edward's Hospital Fund for London.

PMID- 29817847
TI  - Genito-Urinary Surgery.

PMID- 29817848
TI  - Notes and News.

PMID- 29817850
TI  - Bacteriology.

PMID- 29817849
TI  - The League of Mercy.

PMID- 29817851
TI  - Sudden and Unexpected Death in Children.

PMID- 29817852
TI  - The King's Fund and the Hospitals.

PMID- 29817854
TI  - Food and Feeding.

PMID- 29817853
TI  - Acute Diphtheritic Whitlow.

PMID- 29817855
TI  - Syphilis of Upper Air Passages.

PMID- 29817856
TI  - The Hospital Penny Fund.

PMID- 29817857
TI  - Apoplectic Motation.

PMID- 29817858
TI  - Hospital for the Insane in British Columbia.

PMID- 29817860
TI  - The Hull Fishermen's Hospital.

PMID- 29817859
TI  - Wolverhampton Hospital for Women.

PMID- 29817862
TI  - The Ethics of Chloroform Administration.

PMID- 29817861
TI  - The Hospital Officers' Association.

PMID- 29817863
TI  - Annotations.

PMID- 29817864
TI  - Notes and News.

PMID- 29817865
TI  - Orthoform in the Diagnosis of Gastric Ulcer.

PMID- 29817866
TI  - Surgical Operations in Private Practice.

PMID- 29817868
TI  - The Hospital. Nursing Section.

PMID- 29817867
TI  - Prolonged Jaundice.

PMID- 29817869
TI  - The Feeble-Minded.

PMID- 29817870
TI  - Cancer Research.

PMID- 29817871
TI  - Glances at the Hospitals.

PMID- 29817872
TI  - Guild of St. Luke's.

PMID- 29817873
TI  - Diseases of the Stomach.

PMID- 29817874
TI  - Diseases of the Blood.

PMID- 29817875
TI  - The Relief of Distress.

PMID- 29817876
TI  - Bacterial Contamination of Milk.

PMID- 29817877
TI  - Droitwich as a Health Resort.

PMID- 29817878
TI  - King Edward's Hospital Fund for London.

PMID- 29817879
TI  - Surgery of Stomach.

PMID- 29817880
TI  - Construction Notes.

PMID- 29817881
TI  - Notes and News.

PMID- 29817882
TI  - Organo-Therapy in Ancient Times.

PMID- 29817884
TI  - The Hospital Sunday Fund and the "Medical Press".

PMID- 29817883
TI  - Argyrol in Eye-Work.

PMID- 29817885
TI  - Annotations.

PMID- 29817886
TI  - The Story of the Insane from Year to Year.

PMID- 29817887
TI  - New Appliances and Things Medical.

PMID- 29817888
TI  - Fog and Smoke.

PMID- 29817889
TI  - The Passage of Blood by the Bowel.

PMID- 29817890
TI  - The Visit of French Doctors to London.

PMID- 29817891
TI  - The Hospital. Nursing Section.

PMID- 29817892
TI  - Hospital Pharmacopoeias.

PMID- 29817893
TI  - School Hygiene.

PMID- 29817894
TI  - Lectures on the Feeding of Infants: II. Artificial Feeding.

PMID- 29817895
TI  - The League of Mercy.

PMID- 29817896
TI  - Glances at the Hospitals.

PMID- 29817897
TI  - The Influence of Dentition in the Etiology of Epilepsy.

PMID- 29817898
TI  - Surgery.-Hernia.

PMID- 29817899
TI  - Psychiatry.

PMID- 29817900
TI  - Antistreptococcic Serum.

PMID- 29817901
TI  - St. John's Hospital for Diseases of the Skin.

PMID- 29817902
TI  - Fractures and Dislocations of the Carpal Bones.

PMID- 29817903
TI  - Diseases of the Respiratory System.

PMID- 29817904
TI  - Fire Protection at the Royal Portsmouth Hospital.

PMID- 29817905
TI  - Bacteriology.

PMID- 29817906
TI  - Kernig's Sign.

PMID- 29817907
TI  - The Brighton Hospitals.

PMID- 29817908
TI  - Notification of Disease.

PMID- 29817909
TI  - Manchester Hospital for Skin Diseases.

PMID- 29817910
TI  - Osteoplastic Amputations.

PMID- 29817911
TI  - The Hospital. Nursing Section.

PMID- 29817912
TI  - Cerebral and Nerve Surgery.

PMID- 29817913
TI  - Annotations.

PMID- 29817914
TI  - Notes and News.

PMID- 29817915
TI  - Intestinal Obstruction Following Appendicitis.

PMID- 29817916
TI  - Glances at the Hospitals.

PMID- 29817917
TI  - Cirrhosis of the Liver.

PMID- 29817918
TI  - The Story of the Insane from Year to Year.

PMID- 29817919
TI  - L'Entente Cordiale.

PMID- 29817920
TI  - New Appliances and Things Medical.

PMID- 29817921
TI  - Axbridge Workhouse Infirmary.

PMID- 29817922
TI  - Notes and News.

PMID- 29817923
TI  - The Treatment of Sciatica.

PMID- 29817924
TI  - Olive Oil Injections in Constipation.

PMID- 29817925
TI  - The Hospital. Nursing Section.

PMID- 29817926
TI  - Genito-Urinary Diseases.

PMID- 29817927
TI  - The Story of the Insane from Year to Year.

PMID- 29817928
TI  - Our French Visitors.

PMID- 29817929
TI  - New Out-Patient Department at Charing Cross Hospital.

PMID- 29817930
TI  - The Opportunity of St. Bartholomew's.

PMID- 29817931
TI  - Invalid Children's and Association.

PMID- 29817932
TI  - The English of an Elizabethan Physician.

PMID- 29817933
TI  - The Hospital Penny Fund.

PMID- 29817934
TI  - Diseases of the Blood.

PMID- 29817936
TI  - The Small-Pox Epidemic at Dewsbury.

PMID- 29817935
TI  - Diseases of the Stomach.

PMID- 29817937
TI  - Rigor Mortis in Still-Born Children.

PMID- 29817938
TI  - The British Hospital at Sunny Bank, Cannes.

PMID- 29817939
TI  - Glances at the Hospitals.

PMID- 29817940
TI  - Subcutaneous Fibrous Nodules.

PMID- 29817941
TI  - Annotations.

PMID- 29817943
TI  - Hospital Expenditure and Its Reduction.

PMID- 29817942
TI  - Hospital Attendants and Male Servants.

PMID- 29817944
TI  - Cerebral Surgery.

PMID- 29817945
TI  - Glances at the Hospitals.

PMID- 29817947
TI  - Notes on Poor-Law Administration.

PMID- 29817946
TI  - School Hygiene.

PMID- 29817948
TI  - Schistosoma Cattoi : A New Blood Fluke of Man.

PMID- 29817949
TI  - Lectures on the Feeding of Infants: III. Artificial Foods.

PMID- 29817951
TI  - Surgery.-Hernia.

PMID- 29817950
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29817952
TI  - Notes and News.

PMID- 29817953
TI  - More Cancer Research.

PMID- 29817954
TI  - Rodent Ulcer.

PMID- 29817955
TI  - The Hospital. Nursing Section.

PMID- 29817956
TI  - The Cultivation of Trypanosoma from the Leishman-Donovan Body.

PMID- 29817957
TI  - The Central Funds and the Special Hospitals.

PMID- 29817959
TI  - Movable Kidney.

PMID- 29817958
TI  - Dried Milk.

PMID- 29817961
TI  - Psychiatry.

PMID- 29817960
TI  - Proprietary Preparations and the Medical Profession.

PMID- 29817963
TI  - The Story of the Insane from Year to Year.

PMID- 29817962
TI  - Annotations.

PMID- 29817964
TI  - Notes and News.

PMID- 29817965
TI  - Glances at the Hospitals.

PMID- 29817967
TI  - The London Commercial Travellers and the Hospital Sunday Fund.

PMID- 29817966
TI  - Surgery of the Peritoneum.

PMID- 29817968
TI  - 1904.

PMID- 29817969
TI  - The Hospital. Nursing Section.

PMID- 29817971
TI  - Surgery of Stomach.

PMID- 29817970
TI  - The Infant Orphan Asylum, Wanstead.

PMID- 29817973
TI  - Annotations.

PMID- 29817972
TI  - Genito-Urinary Surgery.

PMID- 29817974
TI  - The League of Mercy.

PMID- 29817975
TI  - New Hospital in Rome.

PMID- 29817977
TI  - Practical Departments.

PMID- 29817976
TI  - The Dustbin in "Progressive" Putney.

PMID- 29817978
TI  - Looking Back.

PMID- 29817979
TI  - The Constitution of the Hospital Sunday Fund.

PMID- 29817980
TI  - The Overlaying of Infants.

PMID- 29817981
TI  - The Health of India.

PMID- 29817982
TI  - The Nursing at Woodilee Asylum.

PMID- 29817983
TI  - New Appliances and Things Medical.

PMID- 29817985
TI  - The Hospital. Nursing Section.

PMID- 29817984
TI  - Diseases of the Respiratory System.

PMID- 29817987
TI  - Mosquitoes and Yellow Fever.

PMID- 29817986
TI  - The Hospital Penny Fund.

PMID- 29817988
TI  - The Doncaster and Mexboro' Infectious Hospital.

PMID- 29817989
TI  - The Knee-Jerks in Pneumonia.

PMID- 29817990
TI  - Sir James Crichton Browne on Physical Education.

PMID- 29817991
TI  - Diseases of the Blood.

PMID- 29817992
TI  - Glances at the Hospitals.

PMID- 29817993
TI  - The National Hospital for the Paralysed and Epileptic, Queen Square, Bloomsbury.

PMID- 29817994
TI  - The Use of Tuberculin.

PMID- 29817995
TI  - Anaemic Vomiting.

PMID- 29817996
TI  - Eucaine Lactate.

PMID- 29817997
TI  - Gonorrhoeal Salpingitis in Children.

PMID- 29817998
TI  - The Ophthalmoscope in Medical Practice.

PMID- 29817999
TI  - The Visit of French Medical Men to London.

PMID- 29818000
TI  - Construction Notes.

PMID- 29818001
TI  - Annotations.

PMID- 29818002
TI  - The Story of the Insane from Year to Year.

PMID- 29818003
TI  - Trypanosomiasis in the Congo.

PMID- 29818004
TI  - Dermatology.

PMID- 29818005
TI  - The League of Mercy.

PMID- 29818006
TI  - Doctors in Ancient Ireland.

PMID- 29818007
TI  - Notes and News.

PMID- 29818008
TI  - Congenital Hypertrophic Stenosis of the Pylorus.

PMID- 29818009
TI  - Aerated Waters.

PMID- 29818010
TI  - School and Home.

PMID- 29818011
TI  - Movable Kidney.

PMID- 29818012
TI  - Improvements at the Westminster General Dispensary.

PMID- 29818013
TI  - Opening of the New Isolation Hospital, Acton.

PMID- 29818014
TI  - The Heart and Its Examination.

PMID- 29818015
TI  - Hospital Saturday Fund.

PMID- 29818016
TI  - Diseases of the Kidneys.

PMID- 29818017
TI  - The Hospital. Nursing Section.

PMID- 29818018
TI  - The Engineering Side of Hospital Work: I. Introduction.

PMID- 29818019
TI  - The Symptoms Caused by Intestinal Parasites.

PMID- 29818020
TI  - Annotations.

PMID- 29818021
TI  - Excess of Fat in the Artificial Feeding of Infants.

PMID- 29818022
TI  - Notes and News.

PMID- 29818023
TI  - Construction Notes.

PMID- 29818024
TI  - New Appliances and Things Medical.

PMID- 29818025
TI  - The Decimal Association.

PMID- 29818026
TI  - Diseases of the Blood and Blood-Vessels.

PMID- 29818027
TI  - The Treatment of Pneumonia.

PMID- 29818028
TI  - How to Close Wounds of the Larger Arteries.

PMID- 29818029
TI  - The Winsley Sanatorium for Consumptives at Limpley Stoke, near Bath.

PMID- 29818030
TI  - Tetany Due to Foreign Bodies in the Stomach.

PMID- 29818031
TI  - Royal Orthopaedic Hospital.

PMID- 29818032
TI  - Guardians' Subscriptions to Voluntary Hospitals.

PMID- 29818033
TI  - Diseases of the Blood.

PMID- 29818034
TI  - Notes of 100 Consecutive Successful Operations from over 2,000 Aggregate Labours.

PMID- 29818036
TI  - Annotations.

PMID- 29818035
TI  - St. Bartholomew's Hospital.

PMID- 29818037
TI  - The Causation of Carcinoma.

PMID- 29818038
TI  - Medical Directions for a Toilette in the Seventeenth Century.

PMID- 29818040
TI  - OEdema of the Glottis.

PMID- 29818039
TI  - Diseases of the Kidneys.

PMID- 29818041
TI  - The Engineering Side of Hospital Work: Cold Storage and Refrigeration.

PMID- 29818042
TI  - Medical Inspection of Schools.

PMID- 29818043
TI  - Diseases of the Blood.

PMID- 29818044
TI  - Notes and News.

PMID- 29818046
TI  - Measles in London.

PMID- 29818045
TI  - Hospital Meetings.

PMID- 29818048
TI  - A Ten Years' Review of the Expenditure of the London Hospitals and Its Lessons.

PMID- 29818047
TI  - New Appliances and Things Medical.

PMID- 29818049
TI  - Myelopathic Albumosuria.

PMID- 29818050
TI  - Public Baths in the United States.

PMID- 29818051
TI  - The Hospital. Nursing Section.

PMID- 29818052
TI  - Surgery of the Vermiform Appendix.

PMID- 29818054
TI  - Hospital Expenditure and Its Reduction.

PMID- 29818053
TI  - Diseases of Nerves and Electrical Treatment.

PMID- 29818055
TI  - Psychiatry.

PMID- 29818056
TI  - On Excretion.

PMID- 29818057
TI  - Tracheotomy and Intubation.

PMID- 29818058
TI  - London Orphan Asylum, Watford.

PMID- 29818059
TI  - Seamen's Hospital Society.

PMID- 29818060
TI  - The Hospital. Nursing Section.

PMID- 29818061
TI  - Hospital Meetings.

PMID- 29818062
TI  - Hospital Expenditure and Its Reduction.

PMID- 29818063
TI  - Employers and Employed in America.

PMID- 29818064
TI  - The Use of Raw Meat in the Treatment of Phthisis.

PMID- 29818065
TI  - The Visit of French Doctors to London.

PMID- 29818066
TI  - Annotations.

PMID- 29818067
TI  - Diseases of the Blood and Blood-Vessels.

PMID- 29818068
TI  - The Health of London.

PMID- 29818069
TI  - Feverishness in Children.

PMID- 29818070
TI  - Notes and News.

PMID- 29818071
TI  - Glasgow Western Infirmary.

PMID- 29818072
TI  - Hospital Attendants and Male Servants.

PMID- 29818073
TI  - Diseases of Animals in 1904.

PMID- 29818074
TI  - Names and Theories.

PMID- 29818075
TI  - Medical Education in London.

PMID- 29818077
TI  - Genito-Urinary Surgery.

PMID- 29818076
TI  - Queen's Jubilee Hospital.

PMID- 29818078
TI  - Hospital Meetings.

PMID- 29818079
TI  - Anaesthetics.

PMID- 29818080
TI  - Glances at the Hospitals.

PMID- 29818081
TI  - Hospital Subscriptions and Medical Schools.

PMID- 29818082
TI  - Hospital Questions Which Press.

PMID- 29818083
TI  - The Queen's Jubilee Hospital.

PMID- 29818085
TI  - The Hospital. Nursing Section.

PMID- 29818084
TI  - Free Hospital Patients and the Medical Profession.

PMID- 29818086
TI  - Mucous Disease or Chronic Intestinal Dyspepsia in Children.

PMID- 29818087
TI  - Diseases of the Blood.

PMID- 29818089
TI  - Hospitals and Medical Schools.

PMID- 29818088
TI  - Enteroptosis and Neurasthenia.

PMID- 29818091
TI  - Annotations.

PMID- 29818090
TI  - Chorea.

PMID- 29818093
TI  - Notes and News.

PMID- 29818092
TI  - The Tenure of Sanitary Office.

PMID- 29818094
TI  - The Hospital. Nursing Section.

PMID- 29818095
TI  - Annotations.

PMID- 29818096
TI  - The International Congress of Medicine, Lisbon, 1906.

PMID- 29818097
TI  - Diseases of the Blood.

PMID- 29818098
TI  - The Italian Hospital.

PMID- 29818099
TI  - The Diagnosis of Scarlet Fever.

PMID- 29818101
TI  - A Case for Diagnosis.

PMID- 29818100
TI  - The Resources and Requirements of the Voluntary Hospitals of London.

PMID- 29818102
TI  - The Treatment of Laryngeal Tuberculosis.

PMID- 29818103
TI  - The Story of the Insane from Year to Year.

PMID- 29818104
TI  - A Catalogue of Quacks.

PMID- 29818105
TI  - Notes on Sciatica and Lumbago.

PMID- 29818106
TI  - New Appliances and Things Medical.

PMID- 29818107
TI  - Surgery of the Liver.

PMID- 29818108
TI  - The Medical Aspects of Religious Revivals.

PMID- 29818109
TI  - Aerated Waters.

PMID- 29818110
TI  - The Surgery of the Spleen and Pancreas.

PMID- 29818111
TI  - Practical Points.

PMID- 29818112
TI  - Functional Mental Disorders.

PMID- 29818113
TI  - Notes and News.

PMID- 29818114
TI  - The Engineering Side of Hospital Work: III. Cold Storage and Refrigeration.

PMID- 29818115
TI  - Hospital Meetings, &c.

PMID- 29818116
TI  - School Hygiene.

PMID- 29818117
TI  - Interlobar Empyema.

PMID- 29818118
TI  - The Hospital. Nursing Section.

PMID- 29818119
TI  - New Appliances and Things Medical.

PMID- 29818120
TI  - Bacteriology.

PMID- 29818121
TI  - Convulsions in Infancy and Childhood.

PMID- 29818122
TI  - Hospital Meetings.

PMID- 29818123
TI  - Gastro-Jejunostomy.

PMID- 29818124
TI  - Nurses' Home at the South Shields Union Infirmary.

PMID- 29818125
TI  - Annotations.

PMID- 29818126
TI  - Genito-Urinary Surgery.

PMID- 29818127
TI  - Notes and News.

PMID- 29818128
TI  - The Engineering Side of Hospital Work: IV. The Use of Cold Storage in Hospitals.

PMID- 29818129
TI  - Diseases of the Blood and Blood-Vessels.

PMID- 29818130
TI  - Lesions of the Cervical Sympathetic Nerves.

PMID- 29818131
TI  - Practical Departments.

PMID- 29818132
TI  - Construction Notes.

PMID- 29818133
TI  - Sanitation in the Field.

PMID- 29818135
TI  - Imbecile Children.

PMID- 29818134
TI  - Hospital Questions Which Press.

PMID- 29818136
TI  - The Hospital Funds and the Special Hospitals.

PMID- 29818137
TI  - Annotations.

PMID- 29818139
TI  - A Suggested New Departure in Hospital Administration: III. The Medical
      Superintendent-An Indispensable Official.

PMID- 29818138
TI  - Diabetes.

PMID- 29818141
TI  - Proposed Extension of the Glasgow Maternity Hospital.

PMID- 29818140
TI  - Rheumatism and Gout.

PMID- 29818142
TI  - The Treatment of Cancer.

PMID- 29818143
TI  - Bridging Nerve Defects.

PMID- 29818145
TI  - The Preliminary Education of Medical Students.

PMID- 29818144
TI  - Notes and News.

PMID- 29818146
TI  - Diseases of the Stomach and Intestines.

PMID- 29818147
TI  - The Hospital. Nursing Section.

PMID- 29818148
TI  - Construction Notes.

PMID- 29818149
TI  - Practical Departments.

PMID- 29818150
TI  - Christmas Appeal Supplement.

PMID- 29818151
TI  - The Surgical Aid Society.

PMID- 29818152
TI  - The Bacteriology of Inflammatory Processes in the Abdomen.

PMID- 29818154
TI  - The Medicinal Treatment of Cancer.

PMID- 29818153
TI  - A Model Milk Supply.

PMID- 29818155
TI  - North London or University College Hospital.

PMID- 29818156
TI  - The Treatment of Cancer.

PMID- 29818157
TI  - The Story of the Insane from Year to Year.

PMID- 29818158
TI  - Progress in Psychiatry.

PMID- 29818159
TI  - Loose Prescribing.

PMID- 29818160
TI  - The Effect of Variations in Food on the Digestive Glands.

PMID- 29818161
TI  - "Drunk or Dying" Cases.

PMID- 29818162
TI  - Annotations.

PMID- 29818164
TI  - Hemiplegias.

PMID- 29818163
TI  - Progress in Neurology.

PMID- 29818166
TI  - Notes and News.

PMID- 29818165
TI  - Hospital Meetings.

PMID- 29818168
TI  - Surgery of the Paralyses of Children.

PMID- 29818167
TI  - The Hospital. Nursing Section.

PMID- 29818169
TI  - The Housing Question.

PMID- 29818170
TI  - King Edward's Hospital Fund for London.

PMID- 29818172
TI  - Progress of Surgery.

PMID- 29818171
TI  - Practical Departments.

PMID- 29818173
TI  - Notes and News.

PMID- 29818174
TI  - Hemianopsia.

PMID- 29818175
TI  - Heat Stroke.

PMID- 29818176
TI  - Adherent Pericardium.

PMID- 29818177
TI  - Bacteria and Butter-Making.

PMID- 29818179
TI  - The Hospital. Nursing Section.

PMID- 29818178
TI  - The Law Relating to Lunatics and Persons of Unsound Mind.-III.

PMID- 29818180
TI  - Progress at Guy's Hospital.

PMID- 29818181
TI  - Annotations.

PMID- 29818182
TI  - Tumours of the Abdomen.

PMID- 29818183
TI  - Cataract.

PMID- 29818184
TI  - The Advantages of Poverty.

PMID- 29818185
TI  - Progress in Ophthalmology.

PMID- 29818186
TI  - The Migration of Hospitals.

PMID- 29818187
TI  - Progress in Skin Diseases.

PMID- 29818188
TI  - New Appliances and Things Medical.

PMID- 29818189
TI  - Hospital Meetings.

PMID- 29818190
TI  - Progress in State Medicine.

PMID- 29818191
TI  - The Gelatin Treatment of Haemoptysis.

PMID- 29818193
TI  - What Happens under Mr. Holland's System.

PMID- 29818192
TI  - Syphilis, Tuberculosis, and Fresh Air.

PMID- 29818194
TI  - Progress in Neurology.

PMID- 29818195
TI  - St. Bartholomew's Hospital Committee of Inquiry.

PMID- 29818197
TI  - "Drunk or Dying" Cases.

PMID- 29818196
TI  - Small-Pox at Purfleet.

PMID- 29818199
TI  - Some Points in the Pathology and Therapeutics of Digestion.

PMID- 29818198
TI  - Diseases of the Kidney.

PMID- 29818201
TI  - Hospital Meetings.

PMID- 29818200
TI  - Appendicitis.

PMID- 29818202
TI  - Sites and Population in London.

PMID- 29818203
TI  - St. Bartholomew's Hospital.

PMID- 29818204
TI  - Eclampsia.

PMID- 29818205
TI  - Annotations.

PMID- 29818206
TI  - Progress in Surgery of the Liver and Gall Bladder.

PMID- 29818207
TI  - Notes and News.

PMID- 29818209
TI  - New Appliances and Things Medical.

PMID- 29818208
TI  - The Hospital. Nursing Section.

PMID- 29818211
TI  - The Hospital Officers' Association.

PMID- 29818210
TI  - Notes on Medicine for Medical and Dental Students.

PMID- 29818213
TI  - Modern Sociology.

PMID- 29818212
TI  - Recent Applications of Electricity: III. Static Electricity.

PMID- 29818215
TI  - Progress in Ophthalmology.

PMID- 29818214
TI  - New Appliances and Things Medical.

PMID- 29818216
TI  - Progress in Surgery.

PMID- 29818217
TI  - Hospital Support: Individual and Collective Efforts.

PMID- 29818219
TI  - Annotations.

PMID- 29818218
TI  - The Discovery of the Human Trypanosome.

PMID- 29818220
TI  - The Law Affecting Medical Practitioners.-II.

PMID- 29818221
TI  - Progress in Phototherapy.

PMID- 29818223
TI  - The League of Mercy.

PMID- 29818222
TI  - Pneumonia.

PMID- 29818224
TI  - Notes and News.

PMID- 29818225
TI  - The Registrar-General's Return.

PMID- 29818226
TI  - Post-Operative Non-Septic Leucocytosis.

PMID- 29818227
TI  - Glances at the Hospitals.

PMID- 29818228
TI  - The Introductories.

PMID- 29818229
TI  - The Story of the Insane from Year to Year.

PMID- 29818230
TI  - Notes and News.

PMID- 29818231
TI  - The Hull Sanatorium for Consumption at Withernsea.

PMID- 29818232
TI  - The X-Rays in Sarcoma.

PMID- 29818233
TI  - New Appliances and Things Medical.

PMID- 29818234
TI  - The Hospital. Nursing Section.

PMID- 29818235
TI  - Cancer of the Breast Treated by Removal of Ovaries.

PMID- 29818236
TI  - Enteroptosis.

PMID- 29818237
TI  - Progress in Fevers.

PMID- 29818239
TI  - Orthodox and Unorthodox Medicine.

PMID- 29818238
TI  - The Medicine Stamp Question.

PMID- 29818240
TI  - Annotations.

PMID- 29818241
TI  - The Use of Zinc Gelatine.

PMID- 29818242
TI  - Does Contract Practice Pay?

PMID- 29818243
TI  - Traumatic Ulcerations of the Tongue.

PMID- 29818244
TI  - Compulsory but Unpaid Medical Services.

PMID- 29818245
TI  - Progress in Surgery.

PMID- 29818246
TI  - The Nordrach Sanatorium.

PMID- 29818247
TI  - Contract Medical Practice.

PMID- 29818248
TI  - Progress in Pediatrics.

PMID- 29818249
TI  - Sanatorium for Consumptives at Auchterhouse, Dundee.

PMID- 29818251
TI  - Ligature of Internal Saphenous Vein.

PMID- 29818250
TI  - Surgery of Gall-Bladder and Bile-Ducts.

PMID- 29818252
TI  - Notes and News.

PMID- 29818253
TI  - "Drunk or Dying" Cases.

PMID- 29818255
TI  - London Locomotion.

PMID- 29818254
TI  - New Appliances and Things Medical.

PMID- 29818256
TI  - The Hospital. Nursing Section.

PMID- 29818257
TI  - The Vaccination Act.

PMID- 29818258
TI  - Annotations.

PMID- 29818259
TI  - The Phenomena of Digestion and Their Significance.

PMID- 29818260
TI  - Diseases of the Kidney.

PMID- 29818261
TI  - Visits to Private Asylums.

PMID- 29818262
TI  - Hospital Meetings.

PMID- 29818263
TI  - From a "Resident's" Point of View.

PMID- 29818265
TI  - The After-Care Association.

PMID- 29818264
TI  - Progress in Gynaecology.

PMID- 29818266
TI  - Progress in Genito-Urinary Surgery.

PMID- 29818267
TI  - Heredity and the Question of Forced Labour.

PMID- 29818268
TI  - Annotations.

PMID- 29818269
TI  - Bacterial Toxins.

PMID- 29818270
TI  - Progress in Bacteriology.

PMID- 29818271
TI  - Progress in Gynaecology.

PMID- 29818272
TI  - Spinal Cocainisation in Obstetrics.

PMID- 29818273
TI  - New Appliances and Things Medical.

PMID- 29818274
TI  - The Prevention of Tuberculosis.

PMID- 29818275
TI  - Hospital Meetings.

PMID- 29818277
TI  - The Extinction of Tuberculosis.

PMID- 29818276
TI  - St. Bartholomew's Hospital.

PMID- 29818278
TI  - Notes and News.

PMID- 29818279
TI  - Progress in Genito-Urinary Surgery.

PMID- 29818280
TI  - The Hospital. Nursing Section.

PMID- 29818281
TI  - Diseases of the Breast.

PMID- 29818282
TI  - Bill Relating to Officers of Health.

PMID- 29818283
TI  - If We Had State-Aided Hospitals.

PMID- 29818284
TI  - Progress in Psychiatry.

PMID- 29818285
TI  - Consumption in the Navy.

PMID- 29818286
TI  - Health Resorts.

PMID- 29818287
TI  - Modern Sociology.

PMID- 29818288
TI  - New Appliances and Things Medical.

PMID- 29818289
TI  - Institutional Notes and Queries.

PMID- 29818290
TI  - "Knowing" and "Looking".

PMID- 29818291
TI  - Dr. Vivian Poore's Views.

PMID- 29818292
TI  - Glances at the Hospitals.

PMID- 29818293
TI  - Annotations.

PMID- 29818294
TI  - The Choice of Operation for Uterine Fibroids.

PMID- 29818295
TI  - The Treatment of Typhoid Excreta.

PMID- 29818297
TI  - The Hospital. Nursing Section.

PMID- 29818296
TI  - Progress in Medicine.

PMID- 29818298
TI  - Abbreviations.

PMID- 29818299
TI  - Progress in Pediatrics.

PMID- 29818300
TI  - Spastic and Syphilitic Spinal Paralysis.

PMID- 29818301
TI  - Reaction against Hysterectomy.

PMID- 29818302
TI  - Notes and News.

PMID- 29818303
TI  - The Story of the Insane from Year to Year.

PMID- 29818304
TI  - After-Care Association for the Insane.

PMID- 29818305
TI  - Medical Department of the Royal Navy.

PMID- 29818306
TI  - Notes and News.

PMID- 29818307
TI  - Glances at the Hospitals.

PMID- 29818308
TI  - Progress in Psychiatry.

PMID- 29818309
TI  - The Hospital. Nursing Section.

PMID- 29818310
TI  - The Mansion House and the Hospitals.

PMID- 29818311
TI  - Cancer of Breasts and Ovary.

PMID- 29818312
TI  - Fogs and Gas-Poisoning.

PMID- 29818313
TI  - Inversion of the Uterus.

PMID- 29818314
TI  - Progress in Pediatrics.

PMID- 29818315
TI  - Unexpected Results from Taking Drugs.

PMID- 29818316
TI  - Pleasure as a Vaso-Dilator.

PMID- 29818317
TI  - The Harveian Oration.

PMID- 29818318
TI  - Opening of a New Hospital at Sevenoaks.

PMID- 29818319
TI  - Annotations.

PMID- 29818320
TI  - The Nasal Treatment of Asthma.

PMID- 29818321
TI  - Inflammable Eructations.

PMID- 29818322
TI  - New Appliances and Things Medical.

PMID- 29818323
TI  - Progress in Medicine.

PMID- 29818324
TI  - Hospital Reports.

PMID- 29818325
TI  - The Current from the Main.

PMID- 29818326
TI  - The Congress on Tuberculosis.

PMID- 29818327
TI  - Progress in Diseases of the Blood.

PMID- 29818328
TI  - Progress in Medicine.

PMID- 29818329
TI  - The Hospital. Nursing Section.

PMID- 29818330
TI  - Progress in Bacteriology.

PMID- 29818331
TI  - Annotations.

PMID- 29818332
TI  - Diseases of the Abdomen.

PMID- 29818333
TI  - The Story of the Insane from Year to Year.

PMID- 29818334
TI  - The Place of Arsenic in the Production of Disease.

PMID- 29818335
TI  - New Appliances and Things Medical.

PMID- 29818336
TI  - Tottenham Hospital: Bazaar for the Ladies' Association.

PMID- 29818337
TI  - The Hospital Treatment of Lunacy.

PMID- 29818338
TI  - Cancer and the Quakers.

PMID- 29818339
TI  - Knee-Jerk in Early Tabes.

PMID- 29818340
TI  - Notes and News.

PMID- 29818341
TI  - Hospital Expenditure.

PMID- 29818342
TI  - Notes and News.

PMID- 29818343
TI  - The Bradshaw Lecture.

PMID- 29818344
TI  - Health Resorts.

PMID- 29818345
TI  - Annotations.

PMID- 29818346
TI  - The Hospital. Nursing Section.

PMID- 29818347
TI  - Recent Applications of Electricity: II. Current from the Main.-High Frequency
      Currents.

PMID- 29818348
TI  - (In)temperance among Women.

PMID- 29818349
TI  - The London County Council and the Tottenham Hospital.

PMID- 29818350
TI  - Diseases of the Abdomen.

PMID- 29818351
TI  - Progress in Surgery.

PMID- 29818352
TI  - Progress in Ophthalmology.

PMID- 29818354
TI  - Modern Sociology.

PMID- 29818353
TI  - The Law Affecting Medical Practitioners.-I.

PMID- 29818355
TI  - Gloves in Operative Surgery.

PMID- 29818356
TI  - Notes and News.

PMID- 29818357
TI  - The Civil Hospitals and Dispensaries of the Madras Presidency.

PMID- 29818358
TI  - Progress in Tropical Diseases.

PMID- 29818360
TI  - Diseases of the Abdomen.

PMID- 29818359
TI  - Annotations.

PMID- 29818362
TI  - Diseases of the Heart and Circulation.

PMID- 29818361
TI  - Pneumococcal Peritonitis.

PMID- 29818364
TI  - The Story of the Insane from Year to Year.

PMID- 29818363
TI  - The Law Affecting Medical Practitioners.-IV.

PMID- 29818365
TI  - A New Application of the Electromagnet.

PMID- 29818366
TI  - AEsthetic Surgery.

PMID- 29818367
TI  - Manual Compression of the Heart in Syncope Due to Anaesthetics.

PMID- 29818368
TI  - Visits to Private Asylums.

PMID- 29818369
TI  - The Hospital. Nursing Section.

PMID- 29818370
TI  - Enuresis in Childhood.

PMID- 29818371
TI  - "Sleeping Sickness" in Uganda.

PMID- 29818372
TI  - Forcible Straightening of the Spine in Paraplegia.

PMID- 29818373
TI  - The Task of the New Water Authority.

PMID- 29818374
TI  - Annotations.

PMID- 29818375
TI  - The Hospital. Nursing Section.

PMID- 29818376
TI  - The Power of Unanimity.

PMID- 29818377
TI  - Hospital Meetings.

PMID- 29818379
TI  - Progress in State Medicine.

PMID- 29818378
TI  - Beef Tea.

PMID- 29818380
TI  - New Appliances and Things Medical.

PMID- 29818381
TI  - Thrombosis after Typhoid Fever.

PMID- 29818382
TI  - The General Medical Council.

PMID- 29818383
TI  - The Municipalisation of All Hospitals.

PMID- 29818384
TI  - Atonic Dilatation of the Stomach.

PMID- 29818385
TI  - Progress in Phototherapy.

PMID- 29818386
TI  - A Handy Method of Sterilising Instruments.

PMID- 29818387
TI  - Notes and News.

PMID- 29818388
TI  - The Pathological Society.

PMID- 29818389
TI  - The Law Affecting Medical Practitioners.-III.

PMID- 29818390
TI  - The Treatment of Early Cancer of the Larynx.

PMID- 29818391
TI  - Progress in Diseases of the Blood.

PMID- 29818392
TI  - Notes and News.

PMID- 29818393
TI  - King Edward's Hospital Fund.

PMID- 29818395
TI  - Sir W. R. Gowers on Syphilitic Diseases of the Nervous System.

PMID- 29818394
TI  - Alcohol in Surgery.

PMID- 29818396
TI  - The Fire at the Royal Free Hospital.

PMID- 29818397
TI  - Progress in Phototherapy.

PMID- 29818398
TI  - A Dermatological Mystery Solved.

PMID- 29818399
TI  - Annotations.

PMID- 29818400
TI  - Progress in State Medicine.

PMID- 29818401
TI  - The King's Hospital Fund.

PMID- 29818402
TI  - Malignant Disease of the Pylorus.

PMID- 29818403
TI  - Diseases of the Abdomen.

PMID- 29818404
TI  - Municipalisation or Mooshine?

PMID- 29818405
TI  - Alcohol as a Medicine.

PMID- 29818406
TI  - The Hospital. Nursing Section.

PMID- 29818407
TI  - Certification in Lunacy.

PMID- 29818409
TI  - Progress in Diseases of the Blood.

PMID- 29818408
TI  - Recent Applications of Electricity.

PMID- 29818410
TI  - The London Life Table.

PMID- 29818411
TI  - Annotations.

PMID- 29818412
TI  - Diseases of the Abdomen.

PMID- 29818413
TI  - The Prevention of Typhoid Fever in Armies.

PMID- 29818414
TI  - Modern Sociology.

PMID- 29818415
TI  - Glances at the Hospitals.

PMID- 29818416
TI  - Progress in Surgery.

PMID- 29818417
TI  - New Appliances and Things Medical.

PMID- 29818418
TI  - Lunatic Asylums in the Bombay Presidency.

PMID- 29818419
TI  - Malignant Adenoma of the Kidney.

PMID- 29818421
TI  - The History of Plague.

PMID- 29818420
TI  - Exophthalmic Goitre.

PMID- 29818422
TI  - The Hospital. Nursing Section.

PMID- 29818423
TI  - Notes and News.

PMID- 29818424
TI  - Lunatic Asylums in the North-Western Provinces of India and Oudh.

PMID- 29818425
TI  - Plague Inoculation.

PMID- 29818426
TI  - Mr. Howard Marsh on Infective Arthritis.

PMID- 29818427
TI  - The London Ambulance Service.

PMID- 29818428
TI  - The Sterilisation of Under-Clothing.

PMID- 29818429
TI  - Diseases of the Heart and Circulation.

PMID- 29818430
TI  - Annotations.

PMID- 29818431
TI  - Notes and News.

PMID- 29818432
TI  - The Story of the Insane from Year to Year.

PMID- 29818433
TI  - Visits to Private Asylums.

PMID- 29818434
TI  - Diseases of the Abdomen.

PMID- 29818435
TI  - The Hospital. Nursing Section.

PMID- 29818437
TI  - Progress in Tropical Diseases.

PMID- 29818436
TI  - Beef Tea.

PMID- 29818438
TI  - The Surgical Treatment of Dilated Stomach.

PMID- 29818439
TI  - Glances at the Hospitals.

PMID- 29818440
TI  - The League of Mercy.

PMID- 29818441
TI  - Antiseptics in Chronic Dyspepsia.

PMID- 29818442
TI  - The Royal Infirmary, Dundee.

PMID- 29818443
TI  - Amendment of the Medical Acts.

PMID- 29818444
TI  - "Aseptic" and "Antiseptic" Surgery.

PMID- 29818446
TI  - Empyema in Childhood.

PMID- 29818445
TI  - A Remarkable Epitaph.

PMID- 29818447
TI  - The Typhoid Bacillus.

PMID- 29818448
TI  - A Waning Superstition.

PMID- 29818449
TI  - The Liverpool Infirmary for Sick Children.

PMID- 29818450
TI  - Modern Sociology.

PMID- 29818451
TI  - Progress in Skin Diseases.

PMID- 29818452
TI  - New Appliances and Things Medical.

PMID- 29818454
TI  - Progress in Surgery.

PMID- 29818453
TI  - The Selection of Consumptive Cases for Sanatorium Treatment.

PMID- 29818455
TI  - The Finsen Light.

PMID- 29818456
TI  - The Hospital. Nursing Section.

PMID- 29818457
TI  - The Persistence of the Diphtheria Bacillus.

PMID- 29818458
TI  - Practical Departments.

PMID- 29818459
TI  - The Uncertainties of Bacteriological Diagnosis.

PMID- 29818461
TI  - Notes and News.

PMID- 29818460
TI  - Royal Orthopaedic Hospital.

PMID- 29818462
TI  - Progress in Surgery of the Brain and Nerves.

PMID- 29818463
TI  - Ablation of the Jugular Vein.

PMID- 29818464
TI  - Annotations.

PMID- 29818465
TI  - The Law Relating to Infectious Diseases.-VII.

PMID- 29818466
TI  - The Natural Enemies of the Mosquito.

PMID- 29818467
TI  - Annotations.

PMID- 29818469
TI  - 1902.

PMID- 29818468
TI  - St. George's Hospital.

PMID- 29818470
TI  - The Hospital. Nursing Section.

PMID- 29818471
TI  - Health Resorts.

PMID- 29818472
TI  - Wage Earners and Sickness.

PMID- 29818473
TI  - Inebriate Homes.

PMID- 29818474
TI  - Diseases of the Abdomen.

PMID- 29818475
TI  - The Story of the Insane from Year to Year.

PMID- 29818476
TI  - Progress in Surgery.

PMID- 29818477
TI  - Modern Sociology.

PMID- 29818478
TI  - Theatre Fires and Their Prevention.

PMID- 29818479
TI  - Notes and News.

PMID- 29818480
TI  - The Testing of Drains.

PMID- 29818481
TI  - Progress in State Medicine.

PMID- 29818483
TI  - The Treatment of Gonorrhoeal Synovitis.

PMID- 29818482
TI  - Beef Tea.

PMID- 29818484
TI  - London's New Pay Hospital.

PMID- 29818485
TI  - Diseases of the Heart and Circulation.

PMID- 29818486
TI  - The Immunity to Tuberculosis Possessed by Healthy Men.

PMID- 29818487
TI  - The London Health Report.

PMID- 29818488
TI  - Sanitary Expenditure and Local Indebtedness.

PMID- 29818489
TI  - Practical Departments.

PMID- 29818490
TI  - The Hospital. Nursing Section.

PMID- 29818491
TI  - Laryngotomy as a Preliminary to Mouth and Throat Operations.

PMID- 29818492
TI  - Cancer of the Uterus Treated by "Rays".

PMID- 29818493
TI  - Notes and News.

PMID- 29818494
TI  - Progress in Fevers.

PMID- 29818495
TI  - Progress in Neurology.

PMID- 29818496
TI  - The Future of St. Bartholomew's Hospital.

PMID- 29818497
TI  - The London Hospital.

PMID- 29818498
TI  - The Use of Aspirin in the Treatment of Glycosuria and Diabetes Mellitus.

PMID- 29818499
TI  - Annotations.

PMID- 29818500
TI  - Ankylostomiasis.

PMID- 29818501
TI  - The Etiology of Empyema.

PMID- 29818502
TI  - Intestinal Bacteria.

PMID- 29818503
TI  - Addenbrooke's Hospital, Cambridge.

PMID- 29818504
TI  - New Appliances and Things Medical.

PMID- 29818505
TI  - Two Ways of Looking at an Oyster.

PMID- 29818506
TI  - A Pay Hospital for London.

PMID- 29818507
TI  - The Prize Plans for the King's Sanatorium.

PMID- 29818508
TI  - Annotations.

PMID- 29818509
TI  - The Catheter in Abdomino-Pelvic Operations in Women.

PMID- 29818511
TI  - Suturing a Wounded Heart.

PMID- 29818510
TI  - Diseases of the Heart and Circulation.

PMID- 29818512
TI  - Visits to Private Asylums.

PMID- 29818513
TI  - Notes and News.

PMID- 29818514
TI  - Progress in Surgery.

PMID- 29818515
TI  - A Gunshot Wound of the Heart.

PMID- 29818516
TI  - The Hospital. Nursing Section.

PMID- 29818517
TI  - Fracture of the Greater Process of the Calcaneum.

PMID- 29818518
TI  - Doctors and Education Committees.

PMID- 29818519
TI  - The Question of Hospital Sites in London.

PMID- 29818520
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29818521
TI  - The Roentgen Ray Treatment of Rodent Ulcer.

PMID- 29818522
TI  - Progress in Neurology.

PMID- 29818524
TI  - Orthodoxy and Dissent.

PMID- 29818523
TI  - The Temperature of Workrooms.

PMID- 29818526
TI  - Progress in Surgery of the Stomach.

PMID- 29818525
TI  - The Law Relating to Lunatics and Persons of Unsound Mind.-I.

PMID- 29818527
TI  - Annotations.

PMID- 29818528
TI  - Remarks on Proposed Amendments in the Lunacy Act Relating to Single Patients.

PMID- 29818529
TI  - Rheumatism and Gout.

PMID- 29818530
TI  - Progress in Fevers.

PMID- 29818532
TI  - Modern Sociology.

PMID- 29818531
TI  - Remarks on the Seasonal Incidence of Diarrhoea, and the Part Played by Flies.

PMID- 29818534
TI  - The Hospital. Nursing Section.

PMID- 29818533
TI  - Notes and News.

PMID- 29818536
TI  - Gastric Symptoms in Spinal Disease.

PMID- 29818535
TI  - The Asylum Holocaust.

PMID- 29818537
TI  - New Appliances and Things Medical.

PMID- 29818538
TI  - The Rise of Blood Pressure in Later Life.

PMID- 29818539
TI  - Adenoids and Trachoma.

PMID- 29818540
TI  - Dr. Barnardo and His Work.

PMID- 29818541
TI  - The Voluntary Hospitals.

PMID- 29818542
TI  - Non-Epileptic Convulsions in Growing Children.

PMID- 29818543
TI  - Progress in Radiotherapy.

PMID- 29818544
TI  - Practical Departments.

PMID- 29818546
TI  - The Hospital. Nursing Section.

PMID- 29818545
TI  - Notes and News.

PMID- 29818547
TI  - The Story of the Insane from Year to Year.

PMID- 29818548
TI  - Nottinghamshire Sanatorium for Consumptives at Ratcher Hill, Mansfield.

PMID- 29818549
TI  - Annotations.

PMID- 29818550
TI  - "So-Called" Aseptic Surgery.

PMID- 29818551
TI  - The Medical Inspection of Schools.

PMID- 29818552
TI  - The Micrococcus of Acute Rheumatism.

PMID- 29818554
TI  - Progress in Psychiatry.

PMID- 29818553
TI  - Addenbrooke's Hospital.

PMID- 29818555
TI  - Birth Paralysis of the Upper Extremity.

PMID- 29818556
TI  - Progress of Surgery.

PMID- 29818557
TI  - A Grave Scandal.

PMID- 29818558
TI  - New Appliances and Things Medical.

PMID- 29818559
TI  - Subphrenic Abscess in Appendicitis.

PMID- 29818560
TI  - The Lyon-Cadett Method of Ventilation.

PMID- 29818562
TI  - The Hospital. Nursing Section.

PMID- 29818561
TI  - Operation for Perforation in Typhoid Fever.

PMID- 29818564
TI  - A New Way of Sealing Wounds.

PMID- 29818563
TI  - Progress in Bacteriology.

PMID- 29818565
TI  - The Notification of Measles.

PMID- 29818566
TI  - Phlyctenular Ophthalmia.

PMID- 29818567
TI  - Notes and News.

PMID- 29818568
TI  - Hospitals and the Aristocracy of the Poor.

PMID- 29818570
TI  - Congenital Tuberculosis.

PMID- 29818569
TI  - Modern Sociology.

PMID- 29818571
TI  - Progress in Surgery of the Stomach.

PMID- 29818572
TI  - Paraffin Noses.

PMID- 29818573
TI  - Progress in Fevers.

PMID- 29818576
TI  - Beef Tea.

PMID- 29818574
TI  - Remarks on Proposed Amendments in the Lunacy Act Relating to Single Patients.

PMID- 29818575
TI  - Annotations.

PMID- 29818577
TI  - St. Bartholomew's Hospital.

PMID- 29818578
TI  - When to Operate in Appendicitis.

PMID- 29818579
TI  - A Question for Boards of Guardians.

PMID- 29818580
TI  - Mr. Long and Vaccination.

PMID- 29818581
TI  - Visits to Private Asylums.

PMID- 29818583
TI  - The Hospital. Nursing Section.

PMID- 29818582
TI  - Hemiplegias.

PMID- 29818584
TI  - The Treatment of Puerperal Fever by Formalin.

PMID- 29818585
TI  - The Law Relating to Lunatics and Persons of Unsound Mind.-II.

PMID- 29818586
TI  - Intussusception.

PMID- 29818587
TI  - The Preparation of De-Haemoglobinised Blood Films.

PMID- 29818589
TI  - Progress in Surgery of the Intestines.

PMID- 29818588
TI  - Practical Departments.

PMID- 29818590
TI  - Notes and News.

PMID- 29818591
TI  - Modern Sociology.

PMID- 29818592
TI  - Early Diagnosis in Cancer of the Tongue.

PMID- 29818593
TI  - Alcohol in Diet.

PMID- 29818594
TI  - Hospital Meetings.

PMID- 29818595
TI  - "Drunk or Dying" Cases.

PMID- 29818596
TI  - Treatment by Mechanical Vibration.

PMID- 29818597
TI  - Progress in Radiotherapy.

PMID- 29818599
TI  - St. Bartholomew's Hospital: A Strange Rumour.

PMID- 29818598
TI  - Progress in Surgery of the Pancreas and Spleen.

PMID- 29818600
TI  - The Story of the Insane from Year to Year.

PMID- 29818601
TI  - Annotations.

PMID- 29818602
TI  - New Appliances and Things Medical.

PMID- 29818603
TI  - Light and Heat as Causes of Cataract.

PMID- 29818604
TI  - Progress of the Surgery of the Vermiform Appendix.

PMID- 29818605
TI  - Progress in Abdominal Surgery.

PMID- 29818606
TI  - Notes and News.

PMID- 29818607
TI  - Rural Education.

PMID- 29818609
TI  - New Appliances and Things Medical.

PMID- 29818608
TI  - Hospital Meetings.

PMID- 29818610
TI  - Sporadic Typhoid.

PMID- 29818611
TI  - Modern Sociology.

PMID- 29818613
TI  - Annotations.

PMID- 29818612
TI  - The Hospital. Nursing Section.

PMID- 29818615
TI  - Rheumatism and Gout.

PMID- 29818614
TI  - Alleged Hospital Abuse in Bradford.

PMID- 29818617
TI  - Hospital Questions Which Press.

PMID- 29818616
TI  - Surgery in Rheumatic Fever.

PMID- 29818618
TI  - Auto-Intoxication.

PMID- 29818619
TI  - The Archbishop-Designate and the League of Mercy.

PMID- 29818620
TI  - "Drunk or Dying" Cases.

PMID- 29818621
TI  - Puerperal Insanity.

PMID- 29818622
TI  - The Story of the Insane from Year to Year.

PMID- 29818623
TI  - The Treatment of Tumours of the Bladder.

PMID- 29818625
TI  - Wellingborough Cottage Hospital.

PMID- 29818624
TI  - Remarks on the Seasonal Incidence of Diarrhoea, and the Part Played by Flies.

PMID- 29818626
TI  - Progress in Diseases of the Blood.

PMID- 29818627
TI  - The Commissariat.

PMID- 29818628
TI  - Notes and News.

PMID- 29818629
TI  - Progress in Bacteriology.

PMID- 29818630
TI  - Our Christmas Supplement.

PMID- 29818631
TI  - The Relations between Acute and Chronic Diseases.

PMID- 29818633
TI  - Liverpool Hospital for Consumptives at Delamere Forest.

PMID- 29818632
TI  - The Surgical Treatment of Dilated Stomach.

PMID- 29818635
TI  - The Dangers of Taxis.

PMID- 29818634
TI  - Modern Sociology.

PMID- 29818636
TI  - Preliminary Medical Education.

PMID- 29818637
TI  - X-Rays in Cancer.

PMID- 29818638
TI  - Hospital Meetings.

PMID- 29818639
TI  - Annotations.

PMID- 29818640
TI  - The Metropolitan Hospital Sunday Fund.

PMID- 29818641
TI  - The Hospital. Nursing Section.

PMID- 29818643
TI  - Practical Departments.

PMID- 29818642
TI  - The Surgical Aid Society.

PMID- 29818644
TI  - The Repair of Ruptured Crucial Ligaments by Open Operation.

PMID- 29818645
TI  - New Appliances and Things Medical.

PMID- 29818646
TI  - The Treatment of Hepatic Abscess.

PMID- 29818647
TI  - Race and Mortality.

PMID- 29818648
TI  - Public Health Diplomas.

PMID- 29818649
TI  - The English Conjoint Course.

PMID- 29818651
TI  - The Choice of a Medical School.

PMID- 29818650
TI  - Medicine as a Profession.

PMID- 29818652
TI  - Details of His Majesty's Services.

PMID- 29818654
TI  - Tropical Medicine.

PMID- 29818653
TI  - The Public Health Service as a Career for Medical Men.

PMID- 29818655
TI  - Lectures and Examinations.

PMID- 29818656
TI  - Handbooks for Senior Students and Practitioners.

PMID- 29818657
TI  - Higher Qualifications for Practitioners.

PMID- 29818658
TI  - Post-Graduate Study in Scotland and Ireland.

PMID- 29818659
TI  - Qualification and Registration.

PMID- 29818660
TI  - Graduate Study on the Continent.

PMID- 29818661
TI  - The Cost of Medical Education.

PMID- 29818662
TI  - Medical Education in London.

PMID- 29818663
TI  - The Medical Schools of the United Kingdom.

PMID- 29818664
TI  - The London University Course.

PMID- 29818665
TI  - The Selection of Medical Books.

PMID- 29818666
TI  - London Post-Graduate Institutions.

PMID- 29818667
TI  - The Fellowship.

PMID- 29818668
TI  - The Naval and Military Services as a Career.

PMID- 29818670
TI  - The Cambridge Course.

PMID- 29818669
TI  - Opportunities for Graduate Study in Special Hospitals.

PMID- 29818672
TI  - Alcohol and Exaggeration.

PMID- 29818671
TI  - Some General Considerations.

PMID- 29818673
TI  - Association for Promoting Employment of the Defective.

PMID- 29818674
TI  - Milk, Fresh from the Cow.

PMID- 29818675
TI  - Medical Opinion and Movement.

PMID- 29818676
TI  - Nineteen Cases of Sudden Death.

PMID- 29818677
TI  - Notes on Clinical Methods: Wassermann's Syphilis Serum-Reaction.

PMID- 29818678
TI  - Appendicostomy: The Operation, Its Indications and Its Results.

PMID- 29818679
TI  - Relapsing Eczema.

PMID- 29818680
TI  - Practical Hints upon Medical Examination for Life Assurance.-IV.

PMID- 29818681
TI  - The Domestic Staff-III.

PMID- 29818682
TI  - New Remedies.

PMID- 29818683
TI  - Intussusception: Some Remarks on Its Diagnosis and Treatment.

PMID- 29818684
TI  - Sepsis Neonatorum.

PMID- 29818685
TI  - Some Modern Continental Hospitals.

PMID- 29818686
TI  - The Medical Directory.

PMID- 29818687
TI  - Annotations.

PMID- 29818688
TI  - Enlargements of the Spleen-VI: Splenic Enlargments with Distinctive Blood Changes
      (continued).

PMID- 29818689
TI  - Natural Mineral Waters.

PMID- 29818690
TI  - Cards and the Doctor.

PMID- 29818691
TI  - News and Coming Events.

PMID- 29818692
TI  - Enlargement of the Tonsils-II.

PMID- 29818693
TI  - British Pharmaceutical Conference.

PMID- 29818694
TI  - Some Aspects of Intestinal Obstruction.

PMID- 29818696
TI  - The British Association and Anaesthetics.

PMID- 29818695
TI  - Parotitis after Operations.

PMID- 29818697
TI  - Annotations.

PMID- 29818699
TI  - Medical Opinion and Movement.

PMID- 29818698
TI  - Milk, Fresh from the Cow.

PMID- 29818700
TI  - Graduate Study on the Continent-Germany: X. Strasburg and Freiburg.

PMID- 29818701
TI  - Enlargements of the Spleen-VII: Splenic Enlargements with Distinctive Blood
      Changes (continued).

PMID- 29818703
TI  - The Lunacy Commission.

PMID- 29818702
TI  - The Injuries Incidental to Athletic Exercises.

PMID- 29818704
TI  - Points in the AEtiology of Puerperal Sepsis.

PMID- 29818705
TI  - The Domestic Staff-IV: Meals and Recreation.

PMID- 29818707
TI  - Pigmentation and the Diagnosis of Addison's Disease.

PMID- 29818706
TI  - Sick-Room Cookery.

PMID- 29818708
TI  - News and Coming Events.

PMID- 29818709
TI  - Corneal Ulcerations.

PMID- 29818710
TI  - The Territorial Medical Schools of Instruction.

PMID- 29818711
TI  - Annotations.

PMID- 29818712
TI  - Rectal Drainage of Pelvic Appendicular Abscesses.

PMID- 29818713
TI  - Some Remarks on Hernia: I. Inguinal Hernia.

PMID- 29818714
TI  - Deaths Registration and Burials Bill.

PMID- 29818715
TI  - Some Modern Continental Hospitals.

PMID- 29818716
TI  - Cancer of the Biliary Ducts.

PMID- 29818717
TI  - Lunatics at Large.

PMID- 29818718
TI  - Medical Opinion and Movement.

PMID- 29818720
TI  - Dental Prophylaxis.

PMID- 29818719
TI  - Oxaluria-I.

PMID- 29818721
TI  - The Evolution of a Civic Medical Service.

PMID- 29818723
TI  - A Question of Clothing.

PMID- 29818722
TI  - Points in Prescribing.

PMID- 29818724
TI  - News and Coming Events.

PMID- 29818725
TI  - The Domestic Staff-V: The Cost of Service.

PMID- 29818726
TI  - Cholangitis without Jaundice.

PMID- 29818727
TI  - Enlargements of the Spleen-VIII.

PMID- 29818729
TI  - New Appliances and Things Medical.

PMID- 29818728
TI  - A Hint for Hospital Secretaries.

PMID- 29818731
TI  - Aneurysm: Some Factors in its Causation.

PMID- 29818730
TI  - The Proposed London Hospital for the Insane.

PMID- 29818733
TI  - Man's Superiority.

PMID- 29818732
TI  - Carcinoma of the Uterus. The Importance of Early Diagnosis: Symptoms and
      Treatment.

PMID- 29818734
TI  - News and Coming Events.

PMID- 29818735
TI  - The Pathological Aspect of Primogeniture.

PMID- 29818736
TI  - A New Clinical Thermometer.

PMID- 29818737
TI  - The Uniform Certificate-I.

PMID- 29818738
TI  - Ankylosis.

PMID- 29818739
TI  - The Operative Surgery of Labyrinthitis.

PMID- 29818740
TI  - The R.M.O. and the County Court-III: Evidence and Cross-Examination.

PMID- 29818741
TI  - Medical Opinion and Movement.

PMID- 29818742
TI  - The Nature of "Idiopathic" Epilepsy.

PMID- 29818743
TI  - The Uses of Hydrogen Peroxide.

PMID- 29818744
TI  - The Tissue Changes in Diphtheria.

PMID- 29818745
TI  - Bier's Method and Ulcers of the Leg.

PMID- 29818746
TI  - Social and Poor Law Problems.

PMID- 29818747
TI  - Annotations.

PMID- 29818748
TI  - Rubella and Its Relations to Scarlet Fever and Measles.

PMID- 29818749
TI  - Fiji: Its Hospitals and Diseases.

PMID- 29818750
TI  - A Case for Diagnosis.

PMID- 29818751
TI  - The Uniform Certificate-II.

PMID- 29818753
TI  - Some Aspects of General Peritonitis.

PMID- 29818752
TI  - "Cracked Nipples" and the Management of the Breasts.

PMID- 29818754
TI  - Annotations.

PMID- 29818755
TI  - Medical Opinion and Movement.

PMID- 29818756
TI  - Peculiarities of Children in Disease.

PMID- 29818757
TI  - Bier's Treatment or Unna's Paste.

PMID- 29818758
TI  - The United Kingdom Hospitals Conference, 1908.

PMID- 29818759
TI  - Scabies in General Practice.

PMID- 29818760
TI  - Recovery from Diabetic Coma.

PMID- 29818761
TI  - Aneurysm: Varieties and Symptoms.

PMID- 29818762
TI  - Perineal Prostatectomy.

PMID- 29818763
TI  - Leucopenia in Typhoid Fever.

PMID- 29818764
TI  - Anaesthetisation for Operations within the Abdomen.

PMID- 29818766
TI  - A Machine for Inducing Artificial Respiration.

PMID- 29818765
TI  - The Resident Medical Officers and the Nursing Staff.

PMID- 29818767
TI  - Some Aspects of the Criminal.

PMID- 29818768
TI  - The Hospital Conference, 1908.

PMID- 29818770
TI  - The Operation for Adenoids.

PMID- 29818769
TI  - Prescriptions and Dispensing.

PMID- 29818772
TI  - The Vaccine Treatment of Gonococcal Arthritis.

PMID- 29818771
TI  - News and Coming Events.

PMID- 29818773
TI  - News and Coming Events.

PMID- 29818774
TI  - A Uniform Certificate for Hospital Nurses.

PMID- 29818775
TI  - Perineal Prostatectomy.

PMID- 29818777
TI  - Medical Opinion and Movement.

PMID- 29818776
TI  - Two Cases of Restlessness-II.

PMID- 29818778
TI  - Hyperemesis Gravidarum.

PMID- 29818779
TI  - Some Alkaloidal Specialities.

PMID- 29818780
TI  - Secret Remedies and Branded Products-V.

PMID- 29818781
TI  - Annotations.

PMID- 29818782
TI  - Acute Dilatation of the Stomach.

PMID- 29818783
TI  - The Sense of Death.

PMID- 29818784
TI  - Mercurial Cream for Injection in Syphilis.

PMID- 29818785
TI  - Some Aspects of General Peritonitis-II.

PMID- 29818787
TI  - The Common Task.

PMID- 29818786
TI  - The Voluntary Hospitals, Patients, Payments and State Aid.

PMID- 29818789
TI  - The Apex Beat of the Heart.

PMID- 29818788
TI  - Fiji: Its Hospitals and Diseases-II.

PMID- 29818790
TI  - Pregnancy Complicated by Ovarian Tumours.

PMID- 29818791
TI  - Functional Aphonia.

PMID- 29818792
TI  - Early Tuberculosis of the Kidney.

PMID- 29818793
TI  - The Ophthalmo-Tuberculin Reaction in Private Practice.

PMID- 29818794
TI  - Graduate Study on the Continent.-Germany: I. Graduate Study in Germany.

PMID- 29818795
TI  - Annotations.

PMID- 29818796
TI  - A Case of Cancer of the Liver.

PMID- 29818798
TI  - Medical Opinion and Movement.

PMID- 29818797
TI  - New Appliances and Things Medical.

PMID- 29818800
TI  - Aneurysm: Constitutional Treatment.

PMID- 29818799
TI  - The Personality of the Physician.

PMID- 29818801
TI  - Social and Poor-Law Problems.

PMID- 29818802
TI  - Disorders of the Heart.

PMID- 29818803
TI  - Some Aspects of General Peritonitis-III.

PMID- 29818804
TI  - Difficulty in Micturition in Nervous Patients Admitted to Hospital Wards.

PMID- 29818805
TI  - Australia for the Sons of Professional Men.

PMID- 29818806
TI  - The Predominance of the Clinician.

PMID- 29818807
TI  - News and Coming Events.

PMID- 29818808
TI  - Acne Vulgaris.

PMID- 29818809
TI  - Prescriptions and Dispensing.

PMID- 29818810
TI  - Manslaughter by Administering Noxious Drugs.

PMID- 29818811
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29818812
TI  - Queen Victorias Jubilee Institute for Nurses.

PMID- 29818813
TI  - Annotations.

PMID- 29818814
TI  - The Bedding and Linen Department: I. Muddle or Organisation.

PMID- 29818815
TI  - Hampstead General Hospital.

PMID- 29818816
TI  - Territorial Cavalry Ambulance.

PMID- 29818817
TI  - Superfluous Medical Literature.

PMID- 29818819
TI  - Research Defence Society.

PMID- 29818818
TI  - The North-West London Hospital.

PMID- 29818820
TI  - The Amblyopia Produced by Certain Drugs.

PMID- 29818821
TI  - The Indications and Contra-Indications for Curetting the Uterus.

PMID- 29818822
TI  - The Eosinophilia of Hydatid Disease.

PMID- 29818823
TI  - Aneurysm: Treatment by Ligature.

PMID- 29818824
TI  - Diagram of the Weekly Death Rate in 1908.

PMID- 29818825
TI  - Early and Mild Cases of Mental Disorder.

PMID- 29818827
TI  - Hemiplegia from Tuberculous Meningitis.

PMID- 29818826
TI  - Filariasis-I.

PMID- 29818828
TI  - Graduate Study on the Continent-Germany: II. Berlin as a Centre for Medical
      Study.

PMID- 29818829
TI  - Notes on Treatment.

PMID- 29818830
TI  - Sudden Death in Pleural Effusion Cases.

PMID- 29818832
TI  - The Research Defence Society.

PMID- 29818831
TI  - Cow's Milk and Rickets.

PMID- 29818833
TI  - News and Coming Events.

PMID- 29818834
TI  - Syphilis of the Throat and Nose-I.

PMID- 29818835
TI  - Polyuria.

PMID- 29818836
TI  - A Plea for the Extended Use of Atomised Drugs.

PMID- 29818837
TI  - Medical Opinion and Movement.

PMID- 29818838
TI  - General Practitioners and the Out-Patient Department.

PMID- 29818839
TI  - Obstetrics at Queen Charlotte's Hospital.

PMID- 29818840
TI  - Modern Gas Cooking Stoves.

PMID- 29818842
TI  - Medical Opinion and Movement.

PMID- 29818841
TI  - Hepatic Abscess.

PMID- 29818843
TI  - The Early Diagnosis of Carcinoma Ventriculi.

PMID- 29818844
TI  - South London Practitioners and the Removal of King's College Hospital.

PMID- 29818845
TI  - Glasgow Maternity and Women's Hospital.

PMID- 29818846
TI  - Filing of Newspaper Cuttings.

PMID- 29818847
TI  - The Bedding and Linen Department.

PMID- 29818848
TI  - The AEtiology and Treatment of Nocturnal Enuresis.

PMID- 29818849
TI  - News and Coming Events.

PMID- 29818850
TI  - Aneurysm: Fantastic Surgical Treatment.

PMID- 29818851
TI  - Cow's Milk and Rickets.

PMID- 29818853
TI  - Combretum Sundaicum in the Cure of the Opium Habit.

PMID- 29818852
TI  - Local Treatment of the Commoner Acute Throat Affections.

PMID- 29818854
TI  - Annotations.

PMID- 29818855
TI  - The Surgical Significance of Vomiting.

PMID- 29818856
TI  - Notes on Treatment.

PMID- 29818857
TI  - Opium and Alcohol.

PMID- 29818858
TI  - The Diagnosis of Ringworm of the Scalp.

PMID- 29818859
TI  - Cow's Milk and Rickets.

PMID- 29818860
TI  - Annotations.

PMID- 29818861
TI  - Sudden Death in Infectious Diseases.

PMID- 29818862
TI  - Prescriptions and Dispensing.

PMID- 29818863
TI  - The Evelina Hospital for Sick Children.

PMID- 29818865
TI  - The Bedding and Linen Department-IV.

PMID- 29818864
TI  - Urotropine in Biliary and Pancreatic Inflammations.

PMID- 29818866
TI  - The Examination of Patients during Pregnancy.

PMID- 29818867
TI  - Filariasis-II.

PMID- 29818868
TI  - A Case of Cardiac Arrhythmia.

PMID- 29818869
TI  - Industrial Lead Poisoning.

PMID- 29818870
TI  - Some Special Aneurysms.

PMID- 29818871
TI  - The Surgical Significance of Vomiting.

PMID- 29818872
TI  - Cammidge's Pancreatic Reaction in the Urine.

PMID- 29818873
TI  - The Hot Compressed Air Treatment of Diabetic Gangrene.

PMID- 29818874
TI  - Medical Opinion and Movement.

PMID- 29818875
TI  - The Country's Children.

PMID- 29818876
TI  - News and Coming Events.

PMID- 29818877
TI  - New Appliances and Things Medical.

PMID- 29818878
TI  - The Surgical Significance of Vomiting.-II.

PMID- 29818879
TI  - Graduate Study on the Continent.-Germany: III. Graduate Study Associations of
      Berlin.

PMID- 29818880
TI  - The Control of Infantile Mortality.

PMID- 29818882
TI  - Medical Opinion and Movement.

PMID- 29818881
TI  - Social and Poor-Law Problems.

PMID- 29818884
TI  - On the Management and Treatment of Haemoptysis.

PMID- 29818883
TI  - Radiography and the Early Diagnosis of Phthisis.

PMID- 29818885
TI  - The Diagnosis and Significance of Enlarged Mediastinal Glands.

PMID- 29818886
TI  - Annotations.

PMID- 29818887
TI  - Dietetic Notes.

PMID- 29818888
TI  - Functional or Hysterical Pyrexia.

PMID- 29818889
TI  - Some Medico-Legal Points.

PMID- 29818890
TI  - Local Treatment of Acute Throat Affections.

PMID- 29818891
TI  - Some Conditions under Which Infants Are Nursed Away from Home.

PMID- 29818892
TI  - The Bedding and Linen Department.-II.

PMID- 29818893
TI  - News and Coming Events.

PMID- 29818894
TI  - Reducing Substances in the Urines of Alcoholics.

PMID- 29818895
TI  - Hallucinations.

PMID- 29818896
TI  - Syphilis of the Throat and Nose.-II.

PMID- 29818897
TI  - "Confessio Medici".

PMID- 29818898
TI  - Cow's Milk and Rickets.

PMID- 29818899
TI  - Massage of the Heart.

PMID- 29818900
TI  - Dietl's Crises.

PMID- 29818901
TI  - Some Aspects of Intestinal Obstruction: III. Obstruction due to Conditions in the
      Lumen of the Bowel.

PMID- 29818902
TI  - Sheffield's Opportunity.

PMID- 29818904
TI  - Coxa Vara.

PMID- 29818903
TI  - On Diseases of the Pancreas.

PMID- 29818905
TI  - The Faculty of the Investigator.

PMID- 29818906
TI  - The Sequelae of Enteric Fever-III.

PMID- 29818907
TI  - Nasal Obstruction-I.

PMID- 29818908
TI  - The Treatment of Acute Intussusception.

PMID- 29818909
TI  - The Refusal of Food in Infancy.

PMID- 29818910
TI  - Annotations.

PMID- 29818911
TI  - Abortion from a Legal Point of View.

PMID- 29818912
TI  - News and Coming Events.

PMID- 29818914
TI  - Medical Opinion and Movement.

PMID- 29818913
TI  - New Appliances and Things Medical.

PMID- 29818915
TI  - The Medical Examination of Employees.

PMID- 29818916
TI  - Recommendations and Testimonials.

PMID- 29818918
TI  - Some Aspects of Intestinal Obstruction: Obstruction of the Bowel due to
      Compression from Without.

PMID- 29818917
TI  - Medical Opinion and Movement.

PMID- 29818919
TI  - Overlay or Overlie.

PMID- 29818920
TI  - Graduate Study on the Continent-Germany: IV. A "Ferien Kursus".

PMID- 29818922
TI  - News and Coming Events.

PMID- 29818921
TI  - Secret Remedies and Branded Products-VI.

PMID- 29818924
TI  - Saline Infusion.

PMID- 29818923
TI  - Social and Poor-Law Problems.

PMID- 29818925
TI  - Serous Haemorrhage.

PMID- 29818926
TI  - Two Cases of Acute Abdominal Disease.

PMID- 29818927
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29818928
TI  - The Endowment of Pathological Research.

PMID- 29818929
TI  - Annotations.

PMID- 29818930
TI  - The Bedding and Linen Department-V.

PMID- 29818931
TI  - An Interesting Case of Cerebral Tumour.

PMID- 29818933
TI  - Nasal Polypi.

PMID- 29818932
TI  - Syphilitic Cachexia.

PMID- 29818935
TI  - Phthisis with Perforation of the Bowel.

PMID- 29818934
TI  - Cow's Milk and Rickets.

PMID- 29818936
TI  - New Appliances and Things Medical.

PMID- 29818937
TI  - The Present Condition of the Dental Profession.

PMID- 29818938
TI  - Ammonia in Bismuth Subnitrate.

PMID- 29818939
TI  - Annotations.

PMID- 29818940
TI  - Social and Poor-Law Problems.

PMID- 29818941
TI  - Prescriptions and Dispensing.

PMID- 29818942
TI  - Deaths after Operations.

PMID- 29818943
TI  - Some Aspects of Intestinal Obstruction: Faecal Accumulation and its Treatment.

PMID- 29818944
TI  - Filariasis-III.

PMID- 29818945
TI  - The Relation of Pregnancy to Fibromyomata of the Uterus.

PMID- 29818946
TI  - The Bedding and Linen Department-VII.

PMID- 29818947
TI  - The Effects of Syphilis upon Phthisis.

PMID- 29818948
TI  - News and Coming Events.

PMID- 29818950
TI  - A New View of Diabetes.

PMID- 29818949
TI  - A Case of Tubercular Tumour of the Cerebellum.

PMID- 29818951
TI  - Tetany.

PMID- 29818952
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29818953
TI  - How to See a Post-Nasal Space.

PMID- 29818955
TI  - Graduate Study on the Continent-Germany: V. Special Work in Berlin.

PMID- 29818954
TI  - The Oldest Hospital for Sick Children in the United Kingdom.

PMID- 29818956
TI  - The Sequelae of Enteric Fever-II.

PMID- 29818957
TI  - Anaesthetisation for Operations on the Central Nervous System.

PMID- 29818958
TI  - Medical Opinion and Movement.

PMID- 29818959
TI  - The General Hospitals of the Territorial Army.

PMID- 29818960
TI  - Solutions to Cases Described on Page 238.

PMID- 29818961
TI  - Intermarriage of Cousins.

PMID- 29818962
TI  - Theocin-Sodium Acetate in the Relief of Dropsy.

PMID- 29818963
TI  - The Bedding and Linen Department-VI.

PMID- 29818965
TI  - Cow's Milk and Rickets.

PMID- 29818964
TI  - Lung Disease and Unequal Pupils.

PMID- 29818966
TI  - Cammidge's Pancreatic Reaction.

PMID- 29818967
TI  - New Appliances and Things Medical.

PMID- 29818968
TI  - Medical Opinion and Movement.

PMID- 29818969
TI  - The Causation of Gastric Ulcer.

PMID- 29818971
TI  - Green Plover and Stone-Curlew.

PMID- 29818970
TI  - The Retina in Cases of Albuminuria.

PMID- 29818972
TI  - Infection of the Upper Urinary Tract during Pregnancy.

PMID- 29818973
TI  - The Sequelae of Enteric Fever-I.

PMID- 29818974
TI  - The Case for the Tuberculous Child.

PMID- 29818975
TI  - Pityriasis Rosea.

PMID- 29818976
TI  - Refusal of Food and Forcible Feeding.

PMID- 29818977
TI  - The Surgical Significance of Vomiting.

PMID- 29818978
TI  - Accident Cases.

PMID- 29818979
TI  - News and Coming Events.

PMID- 29818980
TI  - A Case of Carcinoma of the OEsophagus.

PMID- 29818981
TI  - Annotations.

PMID- 29818982
TI  - The Medical Congress at Budapest.

PMID- 29818984
TI  - The Need for Uniformity in the Quality of Drugs.

PMID- 29818983
TI  - Delusions.

PMID- 29818985
TI  - Treatment of Ringworm of the Scalp by Means of the X-Rays.

PMID- 29818986
TI  - Enlargements of the Spleen-III.

PMID- 29818988
TI  - Golf and Physique.

PMID- 29818987
TI  - Myocarditis and Myocardial Diseases-I.

PMID- 29818989
TI  - Medical Opinion and Movement.

PMID- 29818990
TI  - Wanted, a Constructive Policy.

PMID- 29818992
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29818991
TI  - OEsophageal Obstruction.-II.

PMID- 29818993
TI  - The Territorial Army and Camp Sanitation.

PMID- 29818994
TI  - The Care and Control of the Feeble-Minded.

PMID- 29818995
TI  - News and Coming Events.

PMID- 29818996
TI  - Annotations.

PMID- 29818997
TI  - Sick-Room Cookery.

PMID- 29818998
TI  - Practical Hints upon Medical Examination for Life Assurance-II.

PMID- 29818999
TI  - A Dialogue in Blank Verse.

PMID- 29819001
TI  - Some Aspects of Intestinal Obstruction: General Treatment of a Case in which
      Operation has been Refused; and the Choice of Operations.

PMID- 29819000
TI  - The Care of the Children during a Hot Summer.

PMID- 29819002
TI  - The Registration of Deaths Bill.

PMID- 29819003
TI  - Responsibility and Authority.

PMID- 29819004
TI  - Cyclitis and Irido-Cyclitis-I.

PMID- 29819005
TI  - Graduate Study on the Continent-Germany: VIII. Some Other German Universities.

PMID- 29819007
TI  - The Dignity of Medicine.

PMID- 29819006
TI  - Paralysis in Children.

PMID- 29819009
TI  - The Civic Hospital of Venice.

PMID- 29819008
TI  - Calculation of the Date of Labour.

PMID- 29819010
TI  - Acute Retention of Urine-III: Operative Treatment.

PMID- 29819011
TI  - The Varieties of Anaemia in Chronic Tuberculosis.

PMID- 29819012
TI  - A Chemical Theory of Scurvy.

PMID- 29819014
TI  - Annotations.

PMID- 29819013
TI  - The Admission of Women to the Royal College of Surgeons.

PMID- 29819015
TI  - Nursing as a Collegiate Course.

PMID- 29819016
TI  - Infective Endocarditis.

PMID- 29819017
TI  - Some Aspects of Intestinal Obstruction: The History of a Typical Case of Chronic
      Obstruction.

PMID- 29819018
TI  - Nutmeg Poisoning.

PMID- 29819020
TI  - Social and Poor-Law Problems.

PMID- 29819019
TI  - News and Coming Events.

PMID- 29819021
TI  - Medical Opinion and Movement.

PMID- 29819022
TI  - The Prevalence and Cause of Dental Caries.

PMID- 29819023
TI  - New Appliances and Things Medical.

PMID- 29819024
TI  - Enlargements of the Spleen-II: The Physical Signs (continued).

PMID- 29819025
TI  - Annotations.

PMID- 29819026
TI  - Cystitis Due to Bacillus Coli Communis.

PMID- 29819027
TI  - The Preparation of Hot Compressed Air.

PMID- 29819028
TI  - Medical Opinion and Movement.

PMID- 29819029
TI  - The Alkalinity of the Blood in Disease.

PMID- 29819030
TI  - Nasal Obstruction-III.

PMID- 29819031
TI  - A Disease of the Skin Occurring on the Hands of Workers among Sheep.

PMID- 29819032
TI  - Practical Hints upon Medical Examination for Life Assurance-I.

PMID- 29819034
TI  - Prof. P. F. Richter on Some New Ideas on Diseases of Metabolism.

PMID- 29819033
TI  - The Teaching of Stoicism.

PMID- 29819035
TI  - The Administration of Anaesthetics to Children.

PMID- 29819037
TI  - Unsuspected Fractures.

PMID- 29819036
TI  - The Treatment of Acute Pneumonia.

PMID- 29819039
TI  - Cyclitis and Irido-Cyclitis-II.

PMID- 29819038
TI  - Probationers in Excess-II.

PMID- 29819040
TI  - Some Modern Continental Hospitals.

PMID- 29819041
TI  - News and Coming Events.

PMID- 29819042
TI  - The British Medical Association.

PMID- 29819043
TI  - OEsophageal Obstruction.-I.

PMID- 29819044
TI  - Inevitable Abortion and Its Treatment.

PMID- 29819045
TI  - Conjunctivitis in Children.

PMID- 29819047
TI  - Medical Opinion and Movement.

PMID- 29819046
TI  - Tuberculides.

PMID- 29819048
TI  - The Workroom.

PMID- 29819049
TI  - Graduate Study on the Continent-Germany: VI. The Private Clinic.

PMID- 29819050
TI  - The Research Defence Society.

PMID- 29819051
TI  - Clean Milk, Pasteurised Milk, and Sterilised Milk.

PMID- 29819052
TI  - Nauheim Treatment in London.

PMID- 29819054
TI  - Annotations.

PMID- 29819053
TI  - Visit of French Doctors.

PMID- 29819055
TI  - Some Aspects of Intestinal Obstruction: Carcinoma of the Intestine.

PMID- 29819056
TI  - Acute Mania.

PMID- 29819057
TI  - A Proposed Nursing Service for the Territorial Army.

PMID- 29819058
TI  - New Appliances and Things Medical.

PMID- 29819059
TI  - Medical Defence Societies.

PMID- 29819060
TI  - Urethral Caruncle and Urethral Prolapse.

PMID- 29819062
TI  - Prevention or Cure.

PMID- 29819061
TI  - Print-Collecting as a Hobby.

PMID- 29819063
TI  - Acute Rheumatism and Pneumonia.

PMID- 29819064
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29819065
TI  - News and Coming Events.

PMID- 29819066
TI  - The Sequelae of Enteric Fever-IV.

PMID- 29819068
TI  - The Early Signs of Measles.

PMID- 29819067
TI  - A New View of Diabetes.

PMID- 29819069
TI  - League of Mercy Garden Party.

PMID- 29819070
TI  - Suicide.

PMID- 29819071
TI  - The Nervous Manifestations of Rickets.

PMID- 29819072
TI  - The Duty of Hospitals in Regard to Thrift.

PMID- 29819073
TI  - News and Coming Events.

PMID- 29819074
TI  - The Civic Hospital of Venice.

PMID- 29819075
TI  - Secret Remedies and Branded Products-VII.

PMID- 29819077
TI  - The Sequelae of Enteric Fever-V.

PMID- 29819076
TI  - Chronic Laryngitis.

PMID- 29819078
TI  - The Local Treatment of Pain in Gout.

PMID- 29819079
TI  - Tubercle Bacilli in Cardiac Vegetations.

PMID- 29819081
TI  - X-Rays and Hepatic Abscesses.

PMID- 29819080
TI  - Medical Opinion and Movement.

PMID- 29819082
TI  - New Appliances and Things Medical.

PMID- 29819083
TI  - Acute Retention of Urine-I.

PMID- 29819084
TI  - Prescriptions and Dispensing.

PMID- 29819085
TI  - The Temperamental Factor in Disease.

PMID- 29819086
TI  - Annotations.

PMID- 29819087
TI  - Some Aspects of Intestinal Obstruction: Carcinoma as it Affects the Different
      Regions of the Bowel.

PMID- 29819088
TI  - Cases for Diagnosis.

PMID- 29819089
TI  - The Treatment of Labour Complicated by Fibroid Tumours of the Uterus.

PMID- 29819090
TI  - King Edward's Hospital Fund for London.

PMID- 29819091
TI  - Consultations.

PMID- 29819093
TI  - Ringworm Fungus in a Strange Situation.

PMID- 29819092
TI  - Doctors and Socialism.

PMID- 29819094
TI  - New Appliances & Things Medical.

PMID- 29819095
TI  - Some Aspects of Intestinal Obstruction: Obstruction due to Disease of the
      Intestinal Wall other than Carcinoma.

PMID- 29819096
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29819097
TI  - News and Coming Events.

PMID- 29819099
TI  - Lung Troubles after Anaesthetics.

PMID- 29819098
TI  - Annotations.

PMID- 29819100
TI  - Nasal Obstruction-II: The Cause of Nasal Obstruction.

PMID- 29819102
TI  - Medical Opinion and Movement.

PMID- 29819101
TI  - The War on Rats.

PMID- 29819103
TI  - Fat Absorption after Gastrojejunostomy.

PMID- 29819104
TI  - Artificial Respiration.

PMID- 29819105
TI  - The British Red Cross Society and the Territorial General Hospitals.

PMID- 29819106
TI  - The Arbitrament of the Magistrate.

PMID- 29819108
TI  - Some Laundry Statistics.

PMID- 29819107
TI  - Some Common Diseases of the Eye: Their Diagnosis and Treatment.

PMID- 29819109
TI  - Graduate Study on the Continent.

PMID- 29819110
TI  - Acute Retention of Urine-II.

PMID- 29819112
TI  - The Treatment of Whooping Cough.

PMID- 29819111
TI  - Secondary Deposits in Left Supra-Clavicular Glands in Cases of Malignant Disease
      of Abdominal Organs.

PMID- 29819113
TI  - Tuberculin Treatment in General Practice.

PMID- 29819114
TI  - Hemiplegia after Scarlet Fever.

PMID- 29819115
TI  - The Interim Report or the Whisky Commission.

PMID- 29819117
TI  - News and Coming Events.

PMID- 29819116
TI  - Hospitals and Medical Education.

PMID- 29819119
TI  - Some Aspects of Intestinal Obstruction: The History of a Typical Case of Chronic
      Obstruction.

PMID- 29819118
TI  - The Common Task.

PMID- 29819120
TI  - Social and Poor-Law Problems.

PMID- 29819121
TI  - Cerebral Abscess.

PMID- 29819122
TI  - New Appliances and Things Medical.

PMID- 29819123
TI  - A Week in a Caravan.

PMID- 29819124
TI  - Fees Payable to Medical Men as Witnesses.

PMID- 29819125
TI  - Probationers in Excess.

PMID- 29819127
TI  - Enlargements of the Spleen-I.

PMID- 29819126
TI  - Medical Opinion and Movement.

PMID- 29819128
TI  - Finsen Light in the Treatment of Lupus Vulgaris.

PMID- 29819129
TI  - Prescriptions and Dispensing.

PMID- 29819130
TI  - Annotations.

PMID- 29819131
TI  - Bronchiectasis.

PMID- 29819132
TI  - Christian Science.

PMID- 29819133
TI  - Melancholia.

PMID- 29819134
TI  - "Let There Be Light".

PMID- 29819136
TI  - The Laryngeal Affections of Voice-Users.

PMID- 29819135
TI  - A General Practitioner's Views about Locums.

PMID- 29819137
TI  - Annotations.

PMID- 29819138
TI  - News and Coming Events.

PMID- 29819139
TI  - Cyclitis and Irido-Cyclitis.

PMID- 29819140
TI  - New Appliances and Things Medical.

PMID- 29819141
TI  - Tradesmen's Books.

PMID- 29819142
TI  - Medical Opinion and Movement.

PMID- 29819143
TI  - Myocarditis and Myocardial Diseases-II.

PMID- 29819144
TI  - Prescriptions and Dispensing.

PMID- 29819146
TI  - Pelvic Haematocele; with a Somewhat Unusual Case.

PMID- 29819145
TI  - The Inheritance of Insanity.

PMID- 29819148
TI  - Some Modern Continental Hospitals.

PMID- 29819147
TI  - The Value of Buttermilk in Disease.

PMID- 29819149
TI  - The Mode of Entry of the Tubercle Bacillus.

PMID- 29819150
TI  - Some Aspects of Intestinal Obstruction: Operative Treatment (continued).

PMID- 29819151
TI  - Enlargements of the Spleen-IV.

PMID- 29819152
TI  - OEsophageal Obstruction.-III.

PMID- 29819153
TI  - Enlargements of the Spleen-V.

PMID- 29819154
TI  - News and Coming Events.

PMID- 29819155
TI  - Practical Hints upon Medical Examination for Life Assurance.-III.

PMID- 29819156
TI  - The Problem of Heredity.

PMID- 29819157
TI  - The Poisons and Pharmacy Bill.

PMID- 29819158
TI  - Venomous Caterpillars.

PMID- 29819159
TI  - Myocarditis and Myocardial Disease-III.

PMID- 29819160
TI  - The Domestic Staff.

PMID- 29819161
TI  - Labour in Minor Degrees of Pelvic Contraction.

PMID- 29819163
TI  - Conservative Surgery.

PMID- 29819162
TI  - The Psychology of Failure and Success.

PMID- 29819165
TI  - Annotations.

PMID- 29819164
TI  - Useful Methods of Diagnosis and Treatment.

PMID- 29819167
TI  - Graduate Study on the Continent-Germany: IX. Munich and Leipsic.

PMID- 29819166
TI  - Notes on Medical Inspection of School Children.

PMID- 29819168
TI  - Medical Opinion and Movement.

PMID- 29819169
TI  - Epulis.

PMID- 29819171
TI  - The Organisation of a Territorial Army General Hospital.

PMID- 29819170
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29819172
TI  - Prescriptions and Dispensing.

PMID- 29819173
TI  - New Appliances and Things Medical.

PMID- 29819174
TI  - News and Coming Events.

PMID- 29819175
TI  - The X-Rays in Exophthalmic Goitre.

PMID- 29819176
TI  - The Treatment of Trachoma.

PMID- 29819177
TI  - Practical Hints on the Management of Normal and Complicated Breech Cases.

PMID- 29819178
TI  - The Treatment of an Impending Calamity.

PMID- 29819179
TI  - On History in Acute Cases.

PMID- 29819180
TI  - Points in the Treatment of Fistula-In-Ano.

PMID- 29819182
TI  - Medical Opinion and Movement.

PMID- 29819181
TI  - Myocarditis and Myocardial Disease-IV.

PMID- 29819184
TI  - The Domestic Staff-II: Superintendence.

PMID- 29819183
TI  - The Results of Operations for Cancer of the Breast.

PMID- 29819185
TI  - Annotations.

PMID- 29819186
TI  - Enlargement of the Tonsils-I.

PMID- 29819188
TI  - New Appliances and Things Medical.

PMID- 29819187
TI  - The Burden of General Practice.

PMID- 29819189
TI  - Warts and the X-Rays.

PMID- 29819190
TI  - Answers to Correspondents.

PMID- 29819191
TI  - Polygonum Cuspidatum as a Laxative.

PMID- 29819192
TI  - The London Fever Hospital.

PMID- 29819193
TI  - The Health of the Army.

PMID- 29819194
TI  - OEsophageal Obstruction.-IV.

PMID- 29819195
TI  - The Diagnosis of Small-Pox.

PMID- 29819196
TI  - Gastralgia.

PMID- 29819198
TI  - Ladies on Hospital Boards.

PMID- 29819197
TI  - The Story of the Insane from Year to Year.

PMID- 29819199
TI  - Belgrave Hospital for Children, Clapham Road, S.W.

PMID- 29819200
TI  - Diseases of the Heart and Circulation.

PMID- 29819201
TI  - Operation for Tuberculous Glands in the Neck.

PMID- 29819202
TI  - The Hospital. Nursing Section.

PMID- 29819203
TI  - Glances at the Hospitals.

PMID- 29819204
TI  - The Treatment of Burns.

PMID- 29819205
TI  - The Transition to Winter.

PMID- 29819206
TI  - The Byways of Infection.

PMID- 29819207
TI  - Notes and News.

PMID- 29819208
TI  - Annotations.

PMID- 29819209
TI  - A Model Factory.

PMID- 29819210
TI  - Modern Sociology.

PMID- 29819211
TI  - Progress in Bacteriology.

PMID- 29819212
TI  - Operations on Uterine Fibroids.

PMID- 29819213
TI  - The Destruction of Rats.

PMID- 29819214
TI  - Obstinate Prolapse of the Uterus.

PMID- 29819215
TI  - The "One Portal" Panacea.

PMID- 29819216
TI  - New Appliances and Things Medical.

PMID- 29819217
TI  - Progress in Surgery.

PMID- 29819218
TI  - Practical Departments.

PMID- 29819219
TI  - New Lamps for the Light Treatment.

PMID- 29819220
TI  - Progress in Bacteriology.

PMID- 29819222
TI  - Isolation Hospital, Royston.

PMID- 29819221
TI  - Treatment by Light and X-Rays.

PMID- 29819224
TI  - Self-Drugging by the Public.

PMID- 29819223
TI  - English and South African Dysentery.

PMID- 29819226
TI  - Progress in State Medicine.

PMID- 29819225
TI  - The Yellow Fever Experiments in Havanna.

PMID- 29819227
TI  - Annotations.

PMID- 29819228
TI  - Diseases of the Heart and Circulation.

PMID- 29819229
TI  - Notes and News.

PMID- 29819230
TI  - The Management of Lateral Curvature of the Spine (Scoliosis).

PMID- 29819231
TI  - The Hospital Library and Charities Bureau.

PMID- 29819233
TI  - New Appliances and Things Medical.

PMID- 29819232
TI  - Modern Developments of the Voluntary Hospital System.

PMID- 29819234
TI  - Reorganisation of the Army Medical Service.

PMID- 29819235
TI  - Modern Sociology.

PMID- 29819236
TI  - The Rest Cure.

PMID- 29819237
TI  - The Hospital. Nursing Section.

PMID- 29819238
TI  - Antivaccinators.

PMID- 29819239
TI  - The Hospital. Nursing Section.

PMID- 29819240
TI  - Annotations.

PMID- 29819241
TI  - Notes and News.

PMID- 29819242
TI  - Practical Departments.

PMID- 29819244
TI  - New Appliances and Things Medical.

PMID- 29819243
TI  - Progress in Psychiatry.

PMID- 29819245
TI  - Progress in Surgery.

PMID- 29819246
TI  - Progress in Dermatology.

PMID- 29819248
TI  - Ankylostomiasis.

PMID- 29819247
TI  - To Arrest Acute Endocarditis.

PMID- 29819249
TI  - The Obstetrical Society of London.

PMID- 29819250
TI  - Calomel as a Panacea.

PMID- 29819251
TI  - Chronic Bronchitis.

PMID- 29819252
TI  - Rangoon Lunatic Asylum.

PMID- 29819253
TI  - The Story of the Insane from Year to Year.

PMID- 29819254
TI  - Caesarian Section.

PMID- 29819255
TI  - Glances at the Hospitals.

PMID- 29819256
TI  - Professional Reputation.

PMID- 29819257
TI  - The Stourfield Park Sanatorium, Pokesdown, Bournemouth.

PMID- 29819258
TI  - Hospital Meetings.

PMID- 29819259
TI  - The Royal Army Medical Corps.

PMID- 29819260
TI  - The Metropolitan Hospital Saturday Fund.

PMID- 29819261
TI  - Intussusception in Infants.

PMID- 29819262
TI  - Modern Sociology.

PMID- 29819263
TI  - New Appliances and Things Medical.

PMID- 29819264
TI  - Annotations.

PMID- 29819266
TI  - The Toxic Origin of Insanity.

PMID- 29819265
TI  - How Does Small-Pox Spread?

PMID- 29819267
TI  - Notes and News.

PMID- 29819268
TI  - The Hospital. Nursing Section.

PMID- 29819269
TI  - Whey as a Diet in Typhoid Fever.

PMID- 29819270
TI  - Progress in Surgery.

PMID- 29819271
TI  - The Story of the Insane from Year to Year.

PMID- 29819272
TI  - Reversed Test Types.

PMID- 29819274
TI  - Birdlime.

PMID- 29819273
TI  - When to Remove Adenoids.

PMID- 29819275
TI  - Anti-Typhoid Inoculation.

PMID- 29819276
TI  - Aneurysm of the Aorta.

PMID- 29819277
TI  - Diseases of the Kidney.

PMID- 29819278
TI  - Progress in Obstetrics.

PMID- 29819279
TI  - Progress in Roentgen Ray Work.

PMID- 29819280
TI  - The Macclesfield Infirmary Dispute.

PMID- 29819281
TI  - Mediaeval Hospitals in France.

PMID- 29819282
TI  - Hospital Saturday Fund.

PMID- 29819283
TI  - The Medical Year.

PMID- 29819284
TI  - Consultations and Consultants.

PMID- 29819286
TI  - The "Lachnanthes Cure" of Consumption.

PMID- 29819285
TI  - Glances at the Hospitals.

PMID- 29819287
TI  - Annotations.

PMID- 29819288
TI  - National Hospital for the Paralysed and Epileptic.

PMID- 29819289
TI  - The Story of the Insane from Year to Year.

PMID- 29819290
TI  - Progress in State Medicine.

PMID- 29819291
TI  - The Hospital. Nursing Section.

PMID- 29819292
TI  - Lancashire County Asylums.

PMID- 29819293
TI  - The Work of the Metropolitan Asylums Board.-I.

PMID- 29819294
TI  - The Treatment of Albuminuria in Pregnancy.

PMID- 29819295
TI  - Progress of Diseases of the Throat and Nose.

PMID- 29819296
TI  - Intestinal Peristalsis.

PMID- 29819297
TI  - Alcohol in the Causation of Disease.

PMID- 29819298
TI  - A Martyr to Duty.

PMID- 29819299
TI  - Medical Psychology.

PMID- 29819300
TI  - Notes and News.

PMID- 29819301
TI  - Experiments on Hospital Patients.

PMID- 29819302
TI  - Annotations.

PMID- 29819303
TI  - London Fogs.

PMID- 29819304
TI  - Diseases of the Kidney.

PMID- 29819305
TI  - Massage in Simple Fractures of the Leg.

PMID- 29819306
TI  - Stricture of the OEsophagus.

PMID- 29819308
TI  - Notes and News.

PMID- 29819307
TI  - Progress in State Medicine.

PMID- 29819310
TI  - Venous Thrombosis.

PMID- 29819309
TI  - Glances at the Hospitals.

PMID- 29819311
TI  - Rectal Feeding.

PMID- 29819312
TI  - The Hospital. Nursing Section.

PMID- 29819313
TI  - Progress in Bacteriology.

PMID- 29819314
TI  - Age and Activity.

PMID- 29819315
TI  - The Hospitals Association.

PMID- 29819316
TI  - Domestic Ventilation.

PMID- 29819317
TI  - The Story of the Insane from Year to Year.

PMID- 29819318
TI  - Sea Voyages for Inebriety.

PMID- 29819319
TI  - Acute Dilatation of the Stomach.

PMID- 29819320
TI  - The Story of the Insane from Year to Year.

PMID- 29819321
TI  - Notes and News.

PMID- 29819322
TI  - The Hospital. Nursing Section.

PMID- 29819323
TI  - Epidemic Bronchocele.

PMID- 29819324
TI  - Practical Departments.

PMID- 29819325
TI  - Glances at the Hospitals.

PMID- 29819326
TI  - Yellow Fever at Rio.

PMID- 29819327
TI  - The London School of Tropical Medicine.

PMID- 29819328
TI  - Chorea : Rheumatism of the Brain.

PMID- 29819329
TI  - Progress in Dermatology.

PMID- 29819330
TI  - Infection and Predisposition.

PMID- 29819332
TI  - The Prevention of Shock during Operations.

PMID- 29819331
TI  - Hemiplegia.

PMID- 29819333
TI  - The Treatment of Wounded Joints.

PMID- 29819334
TI  - Hospital Meetings, &c.

PMID- 29819335
TI  - Annotations.

PMID- 29819336
TI  - Rheumatoid Arthritis.

PMID- 29819337
TI  - Inoperable Cancer.

PMID- 29819338
TI  - Progress in Diseases of the Thyroid.

PMID- 29819339
TI  - Progress in Psychiatry.

PMID- 29819340
TI  - Oophorectomy in Cancer.

PMID- 29819342
TI  - Matlock House Hydropathic Establishment.

PMID- 29819341
TI  - The State of the Circulatory System in Incurably Deaf Children.

PMID- 29819343
TI  - Progress in Psychiatry.

PMID- 29819345
TI  - Glances at the Hospitals.

PMID- 29819344
TI  - Modern Sociology.

PMID- 29819346
TI  - The Work of the Metropolitan Asylums Board.-II.

PMID- 29819347
TI  - Electric Railways.

PMID- 29819348
TI  - Diseases of the Heart and Circulation.

PMID- 29819349
TI  - Editor's Letter-Box.

PMID- 29819351
TI  - The Hospital. Nursing Section.

PMID- 29819350
TI  - The Cure of Bright's Disease by Operation.

PMID- 29819353
TI  - Progress of Diseases of the Throat and Nose.

PMID- 29819352
TI  - The Cheap Doctor.

PMID- 29819354
TI  - The Story of the Insane from Year to Year.

PMID- 29819355
TI  - Annotations.

PMID- 29819356
TI  - The Fish Theory of Leprosy.

PMID- 29819357
TI  - New Appliances and Things Medical.

PMID- 29819359
TI  - Notes and News.

PMID- 29819358
TI  - Notes and News.

PMID- 29819360
TI  - Prognosis in Nervous Diseases.

PMID- 29819361
TI  - The Treatment of Obstinate Ringworm.

PMID- 29819362
TI  - Progress in Surgery.

PMID- 29819363
TI  - Nervous Diseases and Lunacy Law.

PMID- 29819364
TI  - Lady House Surgeons.

PMID- 29819365
TI  - The Fatality of the Notifiable Diseases.

PMID- 29819366
TI  - Sir Dyce Duckworth on Diatheses.

PMID- 29819367
TI  - Harmless Parasites.

PMID- 29819368
TI  - The Hospital. Nursing Section.

PMID- 29819369
TI  - Diseases of the Kidney.

PMID- 29819370
TI  - Practical Departments.

PMID- 29819371
TI  - New Appliances and Things Medical.

PMID- 29819372
TI  - The Story of the Insane from Year to Year.

PMID- 29819373
TI  - Progress in Neurology.

PMID- 29819375
TI  - Music and Mosquitos.

PMID- 29819374
TI  - Annotations.

PMID- 29819376
TI  - Glances at the Hospitals.

PMID- 29819377
TI  - The Prince of Wales's Hospital Fund.

PMID- 29819378
TI  - The Early Diagnosis of Cancer of the Pylorus.

PMID- 29819379
TI  - Vaccination: Public and Private.

PMID- 29819380
TI  - A "Milk Epidemic" of Scarlet Fever.

PMID- 29819381
TI  - Progress in Diseases of the Blood.

PMID- 29819382
TI  - New Appliances and Things Medical.

PMID- 29819383
TI  - Modern Sociology.

PMID- 29819384
TI  - Domestic Medicine in South Africa.

PMID- 29819385
TI  - Jewish Home for Incurables, Tottenham.

PMID- 29819386
TI  - The Story of the Insane from Year to Year.

PMID- 29819387
TI  - Glances at the Hospitals.

PMID- 29819389
TI  - Progress in Diseases of the Nervous System.

PMID- 29819388
TI  - Roof Gardens.

PMID- 29819390
TI  - Chronic Serpiginous Ulcer of the Cornea.

PMID- 29819391
TI  - The Hospital. Nursing Section.

PMID- 29819392
TI  - School for the Indigent Blind.

PMID- 29819393
TI  - Annotations.

PMID- 29819394
TI  - Exercises for Weak Feet.

PMID- 29819395
TI  - Notes and News.

PMID- 29819396
TI  - The Kidneys and the Cardiovascular System.

PMID- 29819397
TI  - Progress in Neurology.

PMID- 29819398
TI  - Carbonate of Creasote in Pneumonia.

PMID- 29819399
TI  - The Early Home Treatment of Consumption.

PMID- 29819400
TI  - Our Christmas Supplement.

PMID- 29819401
TI  - The Hospital. Nursing Section.

PMID- 29819403
TI  - The Prince of Wales at St. Bartholomew's Hospital.

PMID- 29819402
TI  - Hospital Meetings.

PMID- 29819404
TI  - Progress in Diseases of the Blood.

PMID- 29819405
TI  - Defective Union in Fractures.

PMID- 29819406
TI  - Canvassing.

PMID- 29819407
TI  - The Treatment of Tuberculosis by the Administration of Urea.

PMID- 29819408
TI  - Progress in Ophthalmology.

PMID- 29819409
TI  - Telephones.

PMID- 29819410
TI  - East Anglian Sanatorium for Consumptives at Broomfields, Nayland, Suffolk.

PMID- 29819411
TI  - Notes and News.

PMID- 29819412
TI  - Progress in Disease of Digestive Organs.

PMID- 29819413
TI  - X-Rays in Cancer.

PMID- 29819414
TI  - Foreign Bodies in the Nose.

PMID- 29819415
TI  - New Appliances and Things Medical.

PMID- 29819416
TI  - Annotations.

PMID- 29819417
TI  - Practical Departments.

PMID- 29819419
TI  - The Lessons of Beri-Beri.

PMID- 29819418
TI  - Lady House Surgeons in General Hospitals.

PMID- 29819420
TI  - Laminectomy in Fracture of the Spine.

PMID- 29819421
TI  - Consumptive Cases in Convalescent and Other Homes.

PMID- 29819423
TI  - Progress in Surgery.

PMID- 29819422
TI  - The Bolingbroke Hospital, Wandsworth.

PMID- 29819424
TI  - Annotations.

PMID- 29819425
TI  - Notes and News.

PMID- 29819426
TI  - Progress in Psychiatry.

PMID- 29819427
TI  - Progress in Neurology.

PMID- 29819428
TI  - The Electrocution of Czolgosz.

PMID- 29819429
TI  - An Electric Hot-Water Bottle.

PMID- 29819431
TI  - How to Examine the Mouth of an Infant.

PMID- 29819430
TI  - The Association of Pleurisy with Appendicitis.

PMID- 29819432
TI  - Victoria Hospital for Children.

PMID- 29819433
TI  - Medicine and Sociology.

PMID- 29819434
TI  - The Hospital. Nursing Section.

PMID- 29819435
TI  - Treatment of Enlargement of the Prostate.

PMID- 29819436
TI  - The Election to the General Medical Council.

PMID- 29819437
TI  - Derangements of the Thyroid Gland.

PMID- 29819438
TI  - Dispensaries and Charitable Institutions of the Punjab.

PMID- 29819439
TI  - Notes and News.

PMID- 29819440
TI  - Hospital Meetings.

PMID- 29819441
TI  - Annotations.

PMID- 29819442
TI  - Progress in Surgery.

PMID- 29819443
TI  - Antiseptics on the Battlefield.

PMID- 29819444
TI  - The Story of the Insane from Year to Year.

PMID- 29819445
TI  - Leprosy.

PMID- 29819446
TI  - Glances at the Hospitals.

PMID- 29819447
TI  - Modern Sociology.

PMID- 29819448
TI  - Progress in Ophthalmology.

PMID- 29819450
TI  - Progress in Psychiatry.

PMID- 29819449
TI  - The Hospital. Nursing Section.

PMID- 29819452
TI  - The General Medical Council.

PMID- 29819451
TI  - Syphilitic Brain Disease.

PMID- 29819453
TI  - The Frequency of Gall Stones.

PMID- 29819454
TI  - New Appliances and Things Medical.

PMID- 29819456
TI  - Wynnstay Sanatorium, Burgess Hill, Sussex.

PMID- 29819455
TI  - Our Children.

PMID- 29819458
TI  - Progress in Cerebral Surgery.

PMID- 29819457
TI  - Irrigation of the Urethra.

PMID- 29819459
TI  - Annotations.

PMID- 29819460
TI  - Hospital Meetings.

PMID- 29819461
TI  - National Hospital for the Paralysed and Epileptic: Reorganisation Committee's
      Report and Rules Adopted.

PMID- 29819462
TI  - The Story of the Insane from Year to Year.

PMID- 29819464
TI  - Tight-Lacing, Cycling, and Nephroptosis.

PMID- 29819463
TI  - The Accidental Dislodgement of Renal Calculi.

PMID- 29819465
TI  - How to Examine for Movable Kidney.

PMID- 29819466
TI  - The Hospital. Nursing Section.

PMID- 29819468
TI  - A Model Hospital.

PMID- 29819467
TI  - The National Hospital-The Outlook.

PMID- 29819469
TI  - The Treatment of Chronic Bright's Disease.

PMID- 29819470
TI  - Progress in Pediatrics.

PMID- 29819472
TI  - Notes and News.

PMID- 29819471
TI  - New Appliances and Things Medical.

PMID- 29819474
TI  - The Treatment of Movable Kidney.

PMID- 29819473
TI  - Crabbed Age and Youth.

PMID- 29819475
TI  - Modern Vaccination.

PMID- 29819476
TI  - Progress in Anaesthetics.

PMID- 29819477
TI  - The Hospital. Nursing Section.

PMID- 29819478
TI  - The Charitable Dispensaries of Bengal.

PMID- 29819479
TI  - Rupture of the Tendo Achillis.

PMID- 29819480
TI  - The Story of the Insane from Year to Year.

PMID- 29819481
TI  - Beef Tea and Meat Preparations: I. Introductory.

PMID- 29819483
TI  - Hospital Meetings.

PMID- 29819482
TI  - Annotations.

PMID- 29819484
TI  - Modern Sociology.

PMID- 29819485
TI  - Progress of Diseases of the Throat and Nose.

PMID- 29819486
TI  - Notes and News.

PMID- 29819487
TI  - How to Vaccinate.

PMID- 29819488
TI  - Premature Senility.

PMID- 29819489
TI  - Progress in Psychiatry.

PMID- 29819490
TI  - Changing Fashions in Medical Treatment.

PMID- 29819491
TI  - Tuberculosis among the Jews.

PMID- 29819492
TI  - The "Housing" Question.

PMID- 29819493
TI  - Obstructive Jaundice.

PMID- 29819495
TI  - The Lunacy Bill.

PMID- 29819494
TI  - New Appliances and Things Medical.

PMID- 29819496
TI  - The Administration of Iodide of Potassium in Cases with Obstructed Bronchi.

PMID- 29819497
TI  - Notes and News.

PMID- 29819498
TI  - "The Hospital" Nursing Mirror.

PMID- 29819499
TI  - Annotations.

PMID- 29819500
TI  - The Story of the Insane from Year to Year.

PMID- 29819501
TI  - The Use of Taxis in Reducing Herniae.

PMID- 29819503
TI  - Progress in Surgery.

PMID- 29819502
TI  - Rupture of the Uterus.

PMID- 29819505
TI  - Periscope of Dermatology.

PMID- 29819504
TI  - London School of Tropical Medicine.

PMID- 29819506
TI  - Hospital Meetings, &c.

PMID- 29819507
TI  - Sessional Lectures.

PMID- 29819508
TI  - Modern Sociology.

PMID- 29819509
TI  - Hospital Construction.

PMID- 29819510
TI  - Progress in Medicine.

PMID- 29819511
TI  - Aphasia in Some of Its Practical and Less Known Aspects.

PMID- 29819512
TI  - Chloral Sleep in the Treatment of Chorea.

PMID- 29819513
TI  - The David Lewis Hospital, Liverpool.

PMID- 29819514
TI  - The Hospital. Nursing Section.

PMID- 29819515
TI  - Progress in Surgery.

PMID- 29819517
TI  - An Evil Consequence of Pince-Nez.

PMID- 29819516
TI  - Doctors, Midwives, and Patients.

PMID- 29819518
TI  - Notes and News.

PMID- 29819519
TI  - University College Hospital.

PMID- 29819521
TI  - Plants and Fevers.

PMID- 29819520
TI  - The Hospital Saturday Fund.

PMID- 29819522
TI  - The Abuse of Prescriptons.

PMID- 29819523
TI  - The Relation between Foetus and Pelvis.

PMID- 29819524
TI  - Convalescence at the Sea-Side.

PMID- 29819525
TI  - Annotations.

PMID- 29819526
TI  - Progress in Disease of Digestive Organs.

PMID- 29819527
TI  - St. Mary's Hospital, Paddington.

PMID- 29819528
TI  - The Nervous System in Anaemia.

PMID- 29819529
TI  - New Appliances and Things Medical.

PMID- 29819531
TI  - Progress in Diabetes.

PMID- 29819530
TI  - The Royal Sea-Bathing Hospital, Margate.

PMID- 29819532
TI  - The Royal Eye Hospital.

PMID- 29819533
TI  - Widal's Reaction.

PMID- 29819534
TI  - New Appliances and Things Medical.

PMID- 29819535
TI  - Forsythe versus Law.

PMID- 29819536
TI  - Hospital Meetings.

PMID- 29819537
TI  - Notes and News.

PMID- 29819538
TI  - Progress in Medicine.

PMID- 29819539
TI  - Traumatic Neurasthenia.

PMID- 29819540
TI  - The Central Midwives' Board.

PMID- 29819541
TI  - Feeding in Gastric Ulcer.

PMID- 29819542
TI  - The Hospital. Nursing Section.

PMID- 29819543
TI  - Annotations.

PMID- 29819544
TI  - Progress in Obstetrics.

PMID- 29819545
TI  - New Appliances and Things Medical.

PMID- 29819546
TI  - Hospital Construction.

PMID- 29819547
TI  - Progress in Surgery.

PMID- 29819548
TI  - Coleman v. Coldwell.

PMID- 29819549
TI  - Hospital Meetings, &c.

PMID- 29819550
TI  - The AEtiology of Cancer.

PMID- 29819551
TI  - Cancer Fields.

PMID- 29819552
TI  - Modern Sociology.

PMID- 29819553
TI  - Notes and News.

PMID- 29819554
TI  - Medical Fees in Cottage Hospitals.

PMID- 29819555
TI  - Progress in Medicine.

PMID- 29819556
TI  - A Question of Custom.

PMID- 29819557
TI  - Lobar-Pneumonia, an Acute Specific Fever.

PMID- 29819558
TI  - Annotations.

PMID- 29819559
TI  - Antituberculous Serum.

PMID- 29819560
TI  - "The Hospital" Nursing Mirror.

PMID- 29819561
TI  - Superannuation under the Poor Law.

PMID- 29819562
TI  - Cancer Houses.

PMID- 29819563
TI  - What Can Surgery Do?

PMID- 29819564
TI  - Adenoids and Enuresis.

PMID- 29819565
TI  - Surgical Cleanliness.

PMID- 29819566
TI  - Hospital Meetings.

PMID- 29819567
TI  - New Appliances and Things Medical.

PMID- 29819568
TI  - Passing the Stomach Tube.

PMID- 29819569
TI  - The Sequel in Cases of Pylorectomy.

PMID- 29819570
TI  - Progress of Diseases of the Throat and Nose.

PMID- 29819571
TI  - Enema Rashes.

PMID- 29819573
TI  - Zymotic Disease in London.

PMID- 29819572
TI  - Deaths from Chloroform.

PMID- 29819574
TI  - Dr. Roger Williams on Oophorectomy for Cancer of the Breast.

PMID- 29819575
TI  - Progress in Bacteriology.

PMID- 29819576
TI  - Susceptibility to Re-Vaccination.

PMID- 29819577
TI  - The Control of Intemperance.

PMID- 29819578
TI  - The Work of the Metropolitan Asylums Board.-III.

PMID- 29819579
TI  - Guy's Hospital.

PMID- 29819580
TI  - Annotations.

PMID- 29819581
TI  - Respiratory Troubles after an AEsthetics.

PMID- 29819582
TI  - The Hospital. Nursing Section.

PMID- 29819583
TI  - Progress in Psychiatry.

PMID- 29819584
TI  - Notes and News.

PMID- 29819585
TI  - Modern Sociology.

PMID- 29819586
TI  - Inoculation for Enteric Fever.

PMID- 29819587
TI  - The Story of the Insane from Year to Year.

PMID- 29819588
TI  - Modern Sociology.

PMID- 29819589
TI  - The Sins of the Binaural Stethescope.

PMID- 29819590
TI  - Mr. Buckston Browne's Views.

PMID- 29819591
TI  - The Hospital. Nursing Section.

PMID- 29819593
TI  - Adenoids in Infancy.

PMID- 29819592
TI  - Hospital Meetings.

PMID- 29819594
TI  - Clay versus Gravel.

PMID- 29819595
TI  - Annotations.

PMID- 29819596
TI  - Disease of the Lungs.

PMID- 29819597
TI  - Progress in Fevers.

PMID- 29819598
TI  - Notes and News.

PMID- 29819599
TI  - Progress in Surgery.

PMID- 29819601
TI  - A Hospital for the Insane.

PMID- 29819600
TI  - Glances at the Hospitals.

PMID- 29819602
TI  - Dr. Freyer on His Operation for Enucleation of the Prostate.

PMID- 29819603
TI  - The Treatment of Enlarged Prostate.

PMID- 29819604
TI  - Modern Sociology.

PMID- 29819605
TI  - Notes and News.

PMID- 29819606
TI  - Progress in Medicine.

PMID- 29819607
TI  - Progress in Surgery.

PMID- 29819608
TI  - Institutional Questions.

PMID- 29819609
TI  - Annotations.

PMID- 29819610
TI  - Scarlet Fever in the Tropics.

PMID- 29819611
TI  - The Naval Medical Service.

PMID- 29819612
TI  - Hospital Construction.

PMID- 29819613
TI  - Psilosis or Sprue.

PMID- 29819615
TI  - Lord Rosebery on Hospitals.

PMID- 29819614
TI  - An Address on Aseptic Midwifery.

PMID- 29819616
TI  - Insects and the Dissemination of Infectious Diseases.

PMID- 29819617
TI  - Editor's Letter-Box.

PMID- 29819618
TI  - "The Hospital" Nursing Mirror.

PMID- 29819619
TI  - The Notification of Infectious Diseases.

PMID- 29819621
TI  - The Punishment of the Insane.

PMID- 29819620
TI  - Filarial Periodicity.

PMID- 29819622
TI  - A Brief History of the Metropolitan Hospital Sunday Fund.

PMID- 29819623
TI  - Concentrated Foods.

PMID- 29819624
TI  - The Bacteriological Diagnosis of Diphtheria.

PMID- 29819625
TI  - Notes and News.

PMID- 29819626
TI  - Progress in Surgery.

PMID- 29819627
TI  - Koplik's Sign in Measles.

PMID- 29819628
TI  - Progress in Medicine.

PMID- 29819630
TI  - The Opening of the Bedford County Hospital.

PMID- 29819629
TI  - Ankylosis and Its Treatment.

PMID- 29819631
TI  - Water as a Medicine.

PMID- 29819632
TI  - Muzzling and Rabies.

PMID- 29819633
TI  - Annotations.

PMID- 29819634
TI  - Diet in the Typhoid State.

PMID- 29819635
TI  - "The Hospital" Nursing Mirror.

PMID- 29819636
TI  - Hospital Meetings, &c.

PMID- 29819637
TI  - Private Hospitals and Nursing Homes.

PMID- 29819638
TI  - "The Hospital" Nursing Mirror.

PMID- 29819639
TI  - Hospital Meetings, &c.

PMID- 29819640
TI  - Rapid or Sudden Death in Infants from Unsuspected Causes.

PMID- 29819641
TI  - Prince of Wales's Hospital Fund.

PMID- 29819642
TI  - Notes.

PMID- 29819643
TI  - Practical Points.

PMID- 29819644
TI  - Inversion of the Uterus.

PMID- 29819645
TI  - Annotations.

PMID- 29819646
TI  - The Open-Air Treatment of Consumption.

PMID- 29819648
TI  - Inunction of Creasote in Malarial Fevers.

PMID- 29819647
TI  - Progress in Medicine.

PMID- 29819650
TI  - Civil Hospitals and Dispensaries in Madras Presidency.

PMID- 29819649
TI  - Notes and News.

PMID- 29819652
TI  - The Cause of Cancer.

PMID- 29819651
TI  - New Appliances and Things Medical.

PMID- 29819653
TI  - The Story of the Insane from Year to Year.

PMID- 29819654
TI  - Insomnia.

PMID- 29819655
TI  - Progress in Surgery.

PMID- 29819656
TI  - Modern Sociology.

PMID- 29819657
TI  - The Case of Dr. Lamont.

PMID- 29819658
TI  - Progress in Anaesthetics.

PMID- 29819660
TI  - Queen Charlotte's Nurses' Home.

PMID- 29819659
TI  - Schultze's Method of Artificial Respiration.

PMID- 29819661
TI  - Progress in Anaesthetics.

PMID- 29819662
TI  - Guaiacol Vapour Baths in Bronchiectasis.

PMID- 29819663
TI  - Progress in Medicine.

PMID- 29819664
TI  - Notes and News.

PMID- 29819665
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29819666
TI  - The Colonial Nursing Association: Mr. Chamberlain's Speech.

PMID- 29819667
TI  - Progress in Surgery.

PMID- 29819668
TI  - The Oldest Eye-Hospital in England.

PMID- 29819670
TI  - "The Hospital" Nursing Mirror.

PMID- 29819669
TI  - Tracheotomy in Scarlet Fever.

PMID- 29819672
TI  - Sale of Food and Drugs Bill.

PMID- 29819671
TI  - Drink and Heredity.

PMID- 29819674
TI  - Spirit of Soap as an Antiseptic.

PMID- 29819673
TI  - The Pathology of Suppuration in the Nasal Accessory Sinuses and Its Relationship
      to Nasal Polypus.

PMID- 29819675
TI  - Modern Sociology.

PMID- 29819676
TI  - The Portsmouth Meeting of the British Medical Association.

PMID- 29819677
TI  - Annotations.

PMID- 29819678
TI  - New Appliances and Things Medical.

PMID- 29819679
TI  - Annotations.

PMID- 29819680
TI  - A Porro's Operation with Intraperitoneal Treatment of the Stump.

PMID- 29819681
TI  - Tetranitrate of Erythrol.

PMID- 29819682
TI  - Hospital Meetings, &c.

PMID- 29819683
TI  - The Medical Institutions of Calcutta.

PMID- 29819684
TI  - New Appliances and Things Medical.

PMID- 29819685
TI  - Progress in Medicine.

PMID- 29819687
TI  - Cremation.

PMID- 29819686
TI  - On the Methods of Isolation and the Present Treatment of Infectious Diseases.

PMID- 29819688
TI  - Notes and News.

PMID- 29819689
TI  - Charitable Dispensaries of Bengal.

PMID- 29819691
TI  - An American Commission for the Study of Tropical Diseases.

PMID- 29819690
TI  - Tuberculosis and the Dairy-Farm.

PMID- 29819692
TI  - "The Hospital" Nursing Mirror.

PMID- 29819693
TI  - Progress in Surgery.

PMID- 29819695
TI  - The Queue System at Hospitals.

PMID- 29819694
TI  - Diet for the Fat.

PMID- 29819696
TI  - Modern Sociology.

PMID- 29819697
TI  - Death from Functional Nervous Disease.

PMID- 29819699
TI  - Practical Departments.

PMID- 29819698
TI  - New Appliances.

PMID- 29819701
TI  - Annotations.

PMID- 29819700
TI  - Ventilation.

PMID- 29819703
TI  - The Methods of Examining the Stomach.

PMID- 29819702
TI  - "The Hospital" Nursing Mirror.

PMID- 29819704
TI  - Progress in Medicine.

PMID- 29819705
TI  - Progress in Surgery.

PMID- 29819706
TI  - Hospital Meetings, &c.

PMID- 29819707
TI  - Editor's Letter-Box.

PMID- 29819709
TI  - Notes and News.

PMID- 29819708
TI  - The Origin of Cancer.

PMID- 29819710
TI  - Modern Sociology.

PMID- 29819711
TI  - Influenza.

PMID- 29819712
TI  - On the Nature of Pulmonary Emphysema.

PMID- 29819713
TI  - The Nemesis of Specialism.

PMID- 29819714
TI  - Which Mosquito Is the Enemy?

PMID- 29819715
TI  - The Early Diagnosis and Treatment of Deformities of the Spine.

PMID- 29819716
TI  - Saline Injections in Puerperal Eclampsia.

PMID- 29819717
TI  - Annotations.

PMID- 29819718
TI  - Progress in Surgery.

PMID- 29819719
TI  - Eye Strain and the Rest Cure.

PMID- 29819721
TI  - Summer Diarrhoea.

PMID- 29819720
TI  - New Appliances and Things Medical.

PMID- 29819722
TI  - The Inebriates Act.

PMID- 29819723
TI  - Progress in Medicine.

PMID- 29819724
TI  - Notes.

PMID- 29819725
TI  - The Women's Congress.

PMID- 29819726
TI  - Notes and News.

PMID- 29819727
TI  - Medical Officers and Workhouse Nursing.

PMID- 29819728
TI  - Immediate Personal Supervision.

PMID- 29819729
TI  - Progress in Ophthalmology.

PMID- 29819730
TI  - Practical Points.

PMID- 29819731
TI  - Modern Sociology.

PMID- 29819732
TI  - "The Hospital" Nursing Mirror.

PMID- 29819733
TI  - The Ever-Growing Cost of Hospital Construction.

PMID- 29819734
TI  - The Story of the Insane from Year to Year.

PMID- 29819735
TI  - Progress in Medicine.

PMID- 29819736
TI  - Annotations.

PMID- 29819737
TI  - "The Hospital" Nursing Mirror.

PMID- 29819738
TI  - Lunacy in the Central Provinces of India.

PMID- 29819739
TI  - Progress in Bacteriology.

PMID- 29819741
TI  - The Musculo-Spiral Nerve in Fracture of the Humerus.

PMID- 29819740
TI  - Notes and News.

PMID- 29819742
TI  - The Result of Removal of the Appendages.

PMID- 29819743
TI  - On the Localisation of the Seat of Haemorrhage in Haematuria.

PMID- 29819744
TI  - Typhus Fever.

PMID- 29819745
TI  - Physiology in Education.

PMID- 29819746
TI  - Medical Advertising on the Continent.

PMID- 29819747
TI  - Hospital Meetings, &c.

PMID- 29819748
TI  - Modern Sociology.

PMID- 29819749
TI  - Periscope of Dermatology.

PMID- 29819751
TI  - New Appliances and Things Medical.

PMID- 29819750
TI  - Special Hospital Sunday Supplement.

PMID- 29819752
TI  - Annotations.

PMID- 29819753
TI  - The Medical Council.

PMID- 29819754
TI  - Some Points of Preventive Treatment in the Diseases of Women.

PMID- 29819755
TI  - The Rational Treatment of Consumption.

PMID- 29819756
TI  - Overcrowding in St. Pancras.

PMID- 29819758
TI  - Clinical Society.

PMID- 29819757
TI  - Operation for the Ascites of Cirrhosis.

PMID- 29819760
TI  - On Climate and Sea Voyages in the Treatment of Tuberculosis.

PMID- 29819759
TI  - "The Hospital" Nursing Mirror.

PMID- 29819761
TI  - Notes and News.

PMID- 29819762
TI  - Progress in Obstetrics.

PMID- 29819764
TI  - Progress in Medicine.

PMID- 29819763
TI  - Temperance in the Army.

PMID- 29819766
TI  - Sources of Fallacy in Regard to the Results of Treatment by Climate.

PMID- 29819765
TI  - Hospital Meetings, &c.

PMID- 29819767
TI  - The Story of the Insane from Year to Year.

PMID- 29819768
TI  - Notes.

PMID- 29819769
TI  - New Appliances and Things Medical.

PMID- 29819770
TI  - Hospital Construction.

PMID- 29819772
TI  - Gruel as an Infants' Food.

PMID- 29819771
TI  - Some Ulcers of the Tongue.

PMID- 29819774
TI  - Annotations.

PMID- 29819773
TI  - Hospital Laundries.

PMID- 29819775
TI  - The Prevention and Treatment of Syphilis.

PMID- 29819776
TI  - Spontaneous Fracture in Phosphorus Workers.

PMID- 29819777
TI  - Modern Sociology.

PMID- 29819778
TI  - Institutional Questions.

PMID- 29819780
TI  - Progress in Medicine.

PMID- 29819779
TI  - Compulsory Removal and Detention of Fever Patients.

PMID- 29819781
TI  - The Choice of Bromides in the Treatment of Epilepsy.

PMID- 29819782
TI  - Reciprocity.

PMID- 29819783
TI  - Progress in Surgery.

PMID- 29819784
TI  - Editor's Letter-Box.

PMID- 29819785
TI  - "The Hospital" Nursing Mirror.

PMID- 29819786
TI  - Notes and News.

PMID- 29819787
TI  - Progress in Gynaecology.

PMID- 29819788
TI  - Transfusion in Diabetic Coma.

PMID- 29819789
TI  - Notes and News.

PMID- 29819790
TI  - Annotations.

PMID- 29819791
TI  - The Medical Profession.

PMID- 29819792
TI  - The Medical Schools.

PMID- 29819793
TI  - Modern Sociology.

PMID- 29819794
TI  - "The Hospital" Nursing Mirror.

PMID- 29819795
TI  - Periscope of Dermatology.

PMID- 29819796
TI  - Medical Degrees and Other Qualifications.

PMID- 29819797
TI  - Roentgen Rays.

PMID- 29819798
TI  - The Relation between the Use of Antitoxin and the Occurrence of Diphtheritic
      Paralysis.

PMID- 29819800
TI  - Progress in Surgery.

PMID- 29819799
TI  - New Appliances and Things Medical.

PMID- 29819802
TI  - Prickly Heat.

PMID- 29819801
TI  - The Medical Curriculum.

PMID- 29819803
TI  - Notes.

PMID- 29819804
TI  - The "Domestic" Mosquito.

PMID- 29819805
TI  - The Pathology of Suppuration in the Nasal Accessory Sinuses and Its Relationship
      to Nasal Polypus.

PMID- 29819806
TI  - Notes and News.

PMID- 29819807
TI  - Exploration of the Knee Joint.

PMID- 29819809
TI  - Annotations.

PMID- 29819808
TI  - New Appliances and Things Medical.

PMID- 29819811
TI  - Sir R. Douglas Powell on Recent Advances in Practical Medicine.

PMID- 29819810
TI  - "The Hospital" Nursing Mirror.

PMID- 29819812
TI  - Temperature and Health.

PMID- 29819813
TI  - The British Medical Association Meeting at Portsmouth.

PMID- 29819815
TI  - Progress in Surgery.

PMID- 29819814
TI  - Progress in Medicine.

PMID- 29819816
TI  - Progress in State Medicine.

PMID- 29819817
TI  - Dr. Ward Cousins on the Century's Progress.

PMID- 29819820
TI  - Notes and News.

PMID- 29819819
TI  - The Congress on Tuberculosis.

PMID- 29819818
TI  - Hospital Meetings, &c.

PMID- 29819821
TI  - The Treatment of Superfluous Hairs.

PMID- 29819822
TI  - Prognosis in Operation for Appendicitis.

PMID- 29819823
TI  - Hospital Meetings, &c.

PMID- 29819824
TI  - Annotations.

PMID- 29819826
TI  - Progress in Surgery.

PMID- 29819825
TI  - Hospital Administration.

PMID- 29819827
TI  - "The Hospital" Nursing Mirror.

PMID- 29819828
TI  - Workhouse Infirmaries and Consultants.

PMID- 29819829
TI  - The Treatment of Symptoms.

PMID- 29819830
TI  - New Appliances and Things Medical.

PMID- 29819831
TI  - The Story of the Insane from Year to Year.

PMID- 29819833
TI  - The Detection of Renal Calculi by Aid of Radiography.

PMID- 29819832
TI  - Some Points of Preventive Treatment in the Diseases of Women.

PMID- 29819834
TI  - Progress in Obstetrics.

PMID- 29819835
TI  - Modern Sociology.

PMID- 29819836
TI  - Tuberculin.

PMID- 29819837
TI  - Surgery of the Large Intestine.

PMID- 29819839
TI  - The Diagnosis of Small-Pox.

PMID- 29819838
TI  - Beef Tea and Meat Preparations: III. Nourishing Meat Preparations.

PMID- 29819840
TI  - Progress in Gynaecology.

PMID- 29819841
TI  - Tuberculosis among the Jews.

PMID- 29819842
TI  - Practical Departments.

PMID- 29819843
TI  - Hospital Sunday Fund.

PMID- 29819844
TI  - The Salt Pack in Rheumatic Gout.

PMID- 29819845
TI  - Re-Vaccination.

PMID- 29819846
TI  - Progress in Surgery.

PMID- 29819847
TI  - Modern Sociology.

PMID- 29819848
TI  - Suprarenal Extract as a Haemostatic.

PMID- 29819849
TI  - More Cancer Cures.

PMID- 29819851
TI  - Notes and News.

PMID- 29819850
TI  - Hospital Meetings.

PMID- 29819853
TI  - Obesity.

PMID- 29819852
TI  - Progress in Diseases of the Heart.

PMID- 29819854
TI  - Glances at the Hospitals.

PMID- 29819855
TI  - Annotations.

PMID- 29819857
TI  - Heart Disease in Children.

PMID- 29819856
TI  - The Hospital. Nursing Section.

PMID- 29819858
TI  - Notes and News.

PMID- 29819859
TI  - Progress of Diseases of the Throat and Nose.

PMID- 29819861
TI  - Glances at the Hospitals.

PMID- 29819860
TI  - Beef Tea and Meat Preparations: II. Beef Tea and Meat Preparations Compared.

PMID- 29819863
TI  - Tabes Mesenterica.

PMID- 29819862
TI  - Progress in Surgery.

PMID- 29819864
TI  - Lancashire County Asylums.

PMID- 29819865
TI  - Practical Departments.

PMID- 29819866
TI  - Midwives and Infantile Ophthalmia.

PMID- 29819867
TI  - New Appliances and Things Medical.

PMID- 29819869
TI  - Institutional Notes.

PMID- 29819868
TI  - Annotations.

PMID- 29819870
TI  - Phlegmonous Gastritis.

PMID- 29819871
TI  - A Hair Ball Removed from the Stomach.

PMID- 29819872
TI  - Re-Vaccination.

PMID- 29819873
TI  - The Hospital. Nursing Section.

PMID- 29819874
TI  - Modern Sociology.

PMID- 29819875
TI  - The Story of the Insane from Year to Year.

PMID- 29819877
TI  - Phthisiophobia.

PMID- 29819876
TI  - At Last a Teaching University.

PMID- 29819878
TI  - An Englishman's Account of Some American Hospitals.

PMID- 29819879
TI  - Progress in Diseases of the Heart.

PMID- 29819880
TI  - Modern Sociology.

PMID- 29819881
TI  - How to Thread a Needle.

PMID- 29819882
TI  - The Story of the Insane from Year to Year.

PMID- 29819883
TI  - Progress in Surgery.

PMID- 29819885
TI  - Leprosy in the Baltic Provinces.

PMID- 29819884
TI  - Institutional Questions.

PMID- 29819887
TI  - The Physiological Standardisation of Drugs.

PMID- 29819886
TI  - An Address on Aseptic Midwifery.

PMID- 29819888
TI  - New Appliances and Things Medical.

PMID- 29819889
TI  - Fibroid Phthisis in the Gold Mines.

PMID- 29819890
TI  - Hospital Construction.

PMID- 29819891
TI  - "The Hospital" Nursing Mirror.

PMID- 29819892
TI  - The Borderland of Insanity.

PMID- 29819893
TI  - Notes and News.

PMID- 29819894
TI  - War, Pestilence, and Famine.

PMID- 29819895
TI  - Notes.

PMID- 29819896
TI  - The Importance of Intestinal Bacteria in Digestion.

PMID- 29819897
TI  - Annotations.

PMID- 29819899
TI  - A Study in Insanity.

PMID- 29819900
TI  - Progress in Medicine.

PMID- 29819901
TI  - The Diagnosis of Tumours.

PMID- 29819902
TI  - Progress in Surgery.

PMID- 29819903
TI  - Hospital Meetings, &c.

PMID- 29819905
TI  - Medical Practice by Companies.

PMID- 29819904
TI  - On Removal of the Stomach.

PMID- 29819906
TI  - The Vagaries of Typhoid.

PMID- 29819907
TI  - Notes and News.

PMID- 29819908
TI  - Sporadic Trichinosis.

PMID- 29819909
TI  - Annotations.

PMID- 29819911
TI  - Modern Sociology.

PMID- 29819910
TI  - Prophylactic Cauterisation in Rabies.

PMID- 29819912
TI  - Midwifery and General Practice.

PMID- 29819913
TI  - "The Hospital" Nursing Mirror.

PMID- 29819914
TI  - The National Tobacco Bill.

PMID- 29819915
TI  - Progress in Medicine.

PMID- 29819916
TI  - Pylorectomy.

PMID- 29819917
TI  - The Lord Mayor and "Hospital Saturday".

PMID- 29819919
TI  - Employees and the National Insurance Act.

PMID- 29819918
TI  - Government (Teaching) and Municipal (Non-Teaching) Hospitals.

PMID- 29819920
TI  - British Hospitals Association.

PMID- 29819921
TI  - Institutional Housekeeping.

PMID- 29819923
TI  - The Child under School Age.

PMID- 29819922
TI  - Tuberculin in Arthritis Deformans: Tuberculosis as an AEtiological Factor.

PMID- 29819924
TI  - Hospital and Institutional News.

PMID- 29819925
TI  - Research and Remedies.

PMID- 29819927
TI  - The British Hospitals Association: Conference at Birmingham.

PMID- 29819926
TI  - The Institutional Worker.

PMID- 29819928
TI  - Fire Risks at Hospitals.

PMID- 29819929
TI  - Fitting up the X-Ray Department.

PMID- 29819930
TI  - New Appliances and Things Medical.

PMID- 29819931
TI  - Feeding in Gastric Ulcer.

PMID- 29819932
TI  - Notes and News.

PMID- 29819934
TI  - East London Hospital for Children.

PMID- 29819933
TI  - Chromidrosis.

PMID- 29819935
TI  - Popular Medicine.

PMID- 29819936
TI  - The Radical Treatment of Polypoid Disease of the Nose.

PMID- 29819937
TI  - The Relation of Alcoholism to Suicide.

PMID- 29819938
TI  - Progress in Obstetrics.

PMID- 29819939
TI  - Progress in Cancer.

PMID- 29819940
TI  - The Hospital. Nursing Section.

PMID- 29819941
TI  - The London Hospital.

PMID- 29819942
TI  - Royal Westminster Ophthalmic Hospital.

PMID- 29819943
TI  - The Prince and the Hospitals.

PMID- 29819944
TI  - West Ham Hospital.

PMID- 29819945
TI  - Annotations.

PMID- 29819946
TI  - New Hospital for Women.

PMID- 29819947
TI  - King Edward's Hospital Fund for London.

PMID- 29819948
TI  - Progress in Medicine.

PMID- 29819950
TI  - Preventive Inoculation.

PMID- 29819949
TI  - The Mount Vernon Hospital.

PMID- 29819951
TI  - New Appliances and Things Medical.

PMID- 29819952
TI  - Cocainising the Spinal Cord.

PMID- 29819953
TI  - Annotations.

PMID- 29819954
TI  - The Influence of One Disease upon Another.

PMID- 29819956
TI  - Dangerous Industries.

PMID- 29819955
TI  - Progress in Surgery.

PMID- 29819959
TI  - Notes.

PMID- 29819958
TI  - Hospital Meetings, &c.

PMID- 29819957
TI  - Notes and News.

PMID- 29819960
TI  - The Early Diagnosis and Treatment of Deformities of the Spine.

PMID- 29819961
TI  - Modern Sociology.

PMID- 29819962
TI  - Progress in Medicine.

PMID- 29819964
TI  - The Midland Counties' Home for Incurables.

PMID- 29819963
TI  - The University of London.

PMID- 29819965
TI  - The Twang of the Yankee.

PMID- 29819966
TI  - The Royal College of Surgeons.

PMID- 29819967
TI  - "The Hospital" Nursing Mirror.

PMID- 29819968
TI  - Payments by Patients.

PMID- 29819969
TI  - The Treatment of Iritis.

PMID- 29819970
TI  - Annotations.

PMID- 29819972
TI  - Anti-Tuberculous Vaccines and Sera.

PMID- 29819971
TI  - Notes and News.

PMID- 29819973
TI  - Modern Dietetics.

PMID- 29819974
TI  - The Rational Treatment of Pyrexia in Phthisis.

PMID- 29819975
TI  - The Possibilities of Anti-Typhoid Serum.

PMID- 29819976
TI  - The Agnes Memorial Sanatorium at Denver, Colorado.

PMID- 29819977
TI  - "The Hospital" Nursing Section.

PMID- 29819978
TI  - Doomed before Birth.

PMID- 29819979
TI  - Poor Law Topics.

PMID- 29819980
TI  - Diseases of Children.

PMID- 29819981
TI  - Rheumatism.

PMID- 29819982
TI  - The Heating and Ventilating of the New Harvard Medical Schools.

PMID- 29819983
TI  - The Fifteenth International Congress of Medicine.

PMID- 29819984
TI  - Motor Cars for Doctors: Hints on Buying a Car.

PMID- 29819985
TI  - Diseases of the Circulation.

PMID- 29819986
TI  - Hospital Meetings.

PMID- 29819987
TI  - School Children and Their Industries.

PMID- 29819988
TI  - The Prince of Wales's Hospital Fund of London.

PMID- 29819989
TI  - Micawberism.

PMID- 29819990
TI  - New Appliances and Things Medical.

PMID- 29819991
TI  - Notes and News.

PMID- 29819992
TI  - Progress in Medicine.

PMID- 29819993
TI  - A Case of Lobar Pneumonia and Its Treatment.

PMID- 29819994
TI  - The Clinical Relations of Ataxy.

PMID- 29819995
TI  - St. Thomas's Hospital.

PMID- 29819996
TI  - Modern Sociology.

PMID- 29819997
TI  - Annotations.

PMID- 29819998
TI  - Red Cross Societies in War.

PMID- 29819999
TI  - Hospital Meetings, &c.

PMID- 29820000
TI  - "The Hospital" Nursing Mirror.

PMID- 29820001
TI  - Hospital Construction.

PMID- 29820002
TI  - The Problem of Radiant Heat v. Warmed Air.

PMID- 29820004
TI  - Diet.

PMID- 29820003
TI  - Diseases of Children.

PMID- 29820005
TI  - "The Hospital" Nursing Section.

PMID- 29820006
TI  - The Value of Condensed Milk.

PMID- 29820007
TI  - Genito-Urinary Surgery.

PMID- 29820008
TI  - Diseases of the Intestines.

PMID- 29820009
TI  - Hospital Meetings.

PMID- 29820010
TI  - Hospital Diets in 1764.

PMID- 29820012
TI  - New Poor-Law Infirmary, Leicester.

PMID- 29820011
TI  - Notes and News.

PMID- 29820013
TI  - The Uncertainties of Therapeutics.

PMID- 29820014
TI  - A Study in Poor-Law Expenditure.

PMID- 29820016
TI  - Citrate of Soda in the Feeding of Infants.

PMID- 29820015
TI  - Annotations.

PMID- 29820017
TI  - Diseases Associated with Lymphatic Enlargement.

PMID- 29820018
TI  - The Heart in the Tuberculous.

PMID- 29820019
TI  - Simple Fractures.

PMID- 29820020
TI  - The General Medical Council.

PMID- 29820021
TI  - Hospital Meetings, &c.

PMID- 29820022
TI  - Progress in Medicine.

PMID- 29820023
TI  - National Society for Employment of Epileptics.

PMID- 29820024
TI  - Annotations.

PMID- 29820026
TI  - New Appliances and Things Medical.

PMID- 29820025
TI  - Myopathy.

PMID- 29820027
TI  - Notes and News.

PMID- 29820028
TI  - The Privileges of the Royal Colleges.

PMID- 29820029
TI  - Notes on Health Resorts.

PMID- 29820030
TI  - Progress in Surgery.

PMID- 29820031
TI  - Friedenheim Hospital.

PMID- 29820032
TI  - "The Hospital" Nursing Mirror.

PMID- 29820033
TI  - "Medical Aid" and "Friendly" Societies.

PMID- 29820034
TI  - Metropolitan Provident Medical Association.

PMID- 29820036
TI  - Seven-Day Newspapers.

PMID- 29820035
TI  - Some Points of Preventive Treatment in the Diseases of Women.

PMID- 29820037
TI  - Alkaptonuria.

PMID- 29820038
TI  - Encysted Vesical Calculi.

PMID- 29820039
TI  - A Case of Lobar Pneumonia and Its Treatment.

PMID- 29820040
TI  - Annotations.

PMID- 29820041
TI  - Notes and News.

PMID- 29820042
TI  - The Use of the Veil by Operating Surgeons.

PMID- 29820043
TI  - New Appliances and Things Medical.

PMID- 29820044
TI  - "The Hospital" Nursing Mirror.

PMID- 29820045
TI  - A Consulting Institute.

PMID- 29820046
TI  - Progress in Surgery.

PMID- 29820047
TI  - Progress in Medicine.

PMID- 29820048
TI  - Hospital Meetings, &c.

PMID- 29820049
TI  - The Roentgen Rays and Colour-Blindness.

PMID- 29820050
TI  - Remedies and Their Uses.

PMID- 29820051
TI  - Medical Opinion and Movement.

PMID- 29820052
TI  - Free Spectacles for Children in Public Schools.

PMID- 29820053
TI  - Current Hospital Topics.

PMID- 29820054
TI  - The Value of Anti-Malarial Public Works.

PMID- 29820055
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29820056
TI  - How Progress Came in English Medicine.

PMID- 29820057
TI  - British and American Hospitals: From an Australian Standpoint.

PMID- 29820058
TI  - Underfed Children.

PMID- 29820059
TI  - Graduate Teaching Facilities in London Hospitals: Seamen's Hospital
      (Dreadnought), Greenwich: the London School of Tropical Medicine.

PMID- 29820060
TI  - Special Analytical and Health Commission on Tinned and Preserved Food: III.
      Canned Fish.

PMID- 29820061
TI  - New Appliances and Things Medical.

PMID- 29820063
TI  - Social and Poor-Law Problems.

PMID- 29820062
TI  - Annotations.

PMID- 29820064
TI  - "The Hospital" Nursing Section.

PMID- 29820065
TI  - A Clinical Lecture on Rheumatic Pericarditis.

PMID- 29820066
TI  - Ankylosis and Its Treatment.

PMID- 29820067
TI  - Modern Sociology.

PMID- 29820068
TI  - Acetanilid.

PMID- 29820069
TI  - Annotations.

PMID- 29820070
TI  - Epileptic Lunatics.

PMID- 29820071
TI  - "Contagion" or "Infection".

PMID- 29820072
TI  - Specialism.

PMID- 29820073
TI  - "The Hospital" Nursing Mirror.

PMID- 29820074
TI  - Notes and News.

PMID- 29820075
TI  - The Sanitary Lessons of the Late War in Cuba.

PMID- 29820076
TI  - Long Tube Feeding Bottles.

PMID- 29820077
TI  - Hospital Construction.

PMID- 29820078
TI  - Progress in Medicine.

PMID- 29820079
TI  - Cerebro-Spinal Fever.

PMID- 29820080
TI  - Phosgene Gas.

PMID- 29820082
TI  - The Results of the Antitoxin Treatment of Diphtheria in Germany.

PMID- 29820081
TI  - The Voluntary Notification of Consumption.

PMID- 29820083
TI  - Wanted, a Climate for Bronchitis.

PMID- 29820084
TI  - What Is "Immediate Personal Supervision"?

PMID- 29820086
TI  - Progress in Bacteriology.

PMID- 29820085
TI  - Hospital Meetings, &c.

PMID- 29820088
TI  - Tending Wounded Belligerents under the Protection of the Convention of Geneva.

PMID- 29820087
TI  - The London County Council and the Metropolitan Asylums Board.

PMID- 29820089
TI  - The Dental Clinic Abroad and at Home.

PMID- 29820090
TI  - The Dearth of Candidates for Poor-Law Posts.

PMID- 29820092
TI  - Medical and Sickness Benefits.

PMID- 29820091
TI  - The Voluntary Hospitals and Parliament: Mr. Masterman Turns His Back upon
      Himself.

PMID- 29820093
TI  - An Important Local Government Appointment: Miss Lucy W. Wamsley.

PMID- 29820094
TI  - The Institutional Worker.

PMID- 29820096
TI  - The Chancellor to Confer with the Greater Hospitals.

PMID- 29820095
TI  - The Hospital Almoners' Council.

PMID- 29820097
TI  - Government (Teaching) and Municipal (Non-Teaching) German Hospitals : IX. British
      and German Hospitals: Some Contrasts.

PMID- 29820099
TI  - Consumption and Charity.

PMID- 29820098
TI  - Radiography.

PMID- 29820101
TI  - Hospital and Institutional News.

PMID- 29820100
TI  - Research and Remedies.

PMID- 29820103
TI  - The Hospital Spirit in Torquay: Mr. H. J. Packe on the Progress of the Torbay
      Hospital.

PMID- 29820102
TI  - A Demand for State Aid: Conference at the Guildhall.

PMID- 29820104
TI  - New Workhouse Infirmary at Stepping Hill, Stockport.

PMID- 29820105
TI  - The Fitting and Furnishing of Wards and Operating Theatres.

PMID- 29820107
TI  - Remedies and Their Uses.

PMID- 29820106
TI  - Notes on Liquid Articles of Dietary.

PMID- 29820109
TI  - "The Hospital" Nursing Section.

PMID- 29820108
TI  - Bread-Making in Country Districts.

PMID- 29820111
TI  - The Depreciation of Medicine-Its Causes and Remedies.

PMID- 29820110
TI  - Special Analytical and Health Commission on Tinned and Preserved Food: XI.
      Preserved Fruits.

PMID- 29820112
TI  - Annotations.

PMID- 29820113
TI  - The Methylene Blue Reaction of Russo in Enteric Fever.

PMID- 29820115
TI  - Medical Opinion and Movement.

PMID- 29820114
TI  - A Sanatorium and Market Garden.

PMID- 29820116
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29820117
TI  - The Unliveable Misery.

PMID- 29820118
TI  - Observations on the Declining Birth-Rate.

PMID- 29820119
TI  - A Key to the Theory of Opsonins.

PMID- 29820120
TI  - Doctors Aboard Ship.

PMID- 29820121
TI  - Crippled Children's Hampers.

PMID- 29820123
TI  - The Neglect of Asepsis in Ward Work.

PMID- 29820122
TI  - The Chadwick Trust Lectures.

PMID- 29820124
TI  - The Fight for Free Choice of Doctor: Mr. E. B. Turner, F.R.C.S., Describes the
      London Campaign.

PMID- 29820125
TI  - The Institutional Worker.

PMID- 29820126
TI  - An Australian Parliament and a Charities Bill: The Managers' Attitude to Its
      Proposals.

PMID- 29820127
TI  - Insanity and the Neuropathic Inheritance.

PMID- 29820128
TI  - Complaints and the Saturday Fund.

PMID- 29820129
TI  - The Alterations to Bromley Cottage Hospital.

PMID- 29820130
TI  - An Efficient Ambulance Service for London: The County Council Blocks the Way.

PMID- 29820132
TI  - A Recent Outbreak of Typhus Fever.

PMID- 29820131
TI  - Private Arrangements for Medical Benefit.

PMID- 29820134
TI  - The Function of Lactation and Artificial Feeding.

PMID- 29820133
TI  - The Future of the Small Friendly Societies.

PMID- 29820136
TI  - Hospital and Institutional News.

PMID- 29820135
TI  - Institutional Needs.

PMID- 29820137
TI  - New Aspects of the Consumption Problem.

PMID- 29820138
TI  - The Press, the Working Classes, and Parliament.

PMID- 29820140
TI  - Hospital Needs.

PMID- 29820139
TI  - The Clinical Laboratory: Its Value in the Actual Treatment of the Patient.

PMID- 29820141
TI  - Research and Remedies.

PMID- 29820142
TI  - By the Way.

PMID- 29820143
TI  - Marr's Patent Drying Machine.

PMID- 29820144
TI  - Government (Teaching) and Municipal (Non-Teaching German Hospitals : A German
      Critic on Voluntary Methods.-VI. German Practitioners' Fees from Hospital
      Patients.

PMID- 29820145
TI  - Readers' Questions with Practical Answers.

PMID- 29820147
TI  - Legal Notes for Institutional Workers.

PMID- 29820146
TI  - Chichester General Infirmary: The New Laundry.

PMID- 29820148
TI  - The Gloves-Bill: All-Gloves Versus No Gloves.

PMID- 29820149
TI  - Coventry and Warwickshire Hospital Laundry.

PMID- 29820150
TI  - Hospital and Institutional News.

PMID- 29820151
TI  - Proposed Memorial to Dr. Ranking.

PMID- 29820152
TI  - The Differential Diagnosis of Intestinal Haemorrhage: Some Symptoms of
      Obstruction and Disease.

PMID- 29820153
TI  - National Insurance: A Warning from Germany: The Lesson of Leipzig.

PMID- 29820154
TI  - The Dangers of Electricity in Treatment: Address by Professor Jellinek, of
      Vienna.

PMID- 29820155
TI  - Should Intercepting Traps Be Omitted?

PMID- 29820157
TI  - A Hospital Letters Exchange Bureau.

PMID- 29820156
TI  - The Government and the Voluntary Hospitals.

PMID- 29820158
TI  - The Institutional Worker.

PMID- 29820159
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29820160
TI  - The Lessons of a Rebuilding Scheme: Mr. H. Jennings on the Chelsea Hospital
      Extension.

PMID- 29820161
TI  - The New York School Medical Service.

PMID- 29820162
TI  - Doctors and Insurance: Remuneration Increased to 8s. 6d. Per Member.

PMID- 29820163
TI  - Research and Remedies.

PMID- 29820164
TI  - Pain and Medical Research.

PMID- 29820165
TI  - Government (Teaching) and Municipal (Non-Teaching) German Hospitals : III. No
      Free but all Pay Patients.

PMID- 29820166
TI  - Fitting up the X-Ray Department.

PMID- 29820168
TI  - The Red Cross Society of Japan During Peace and War. By a Life Member.

PMID- 29820167
TI  - The Status of the Workhouse Medical Officer: Dr. C. Thackray Parsons, Medical
      Superintendent of Fulham Infirmary, on the Opportunity of To-Day.

PMID- 29820170
TI  - Unemployment Insurance.

PMID- 29820169
TI  - Hospital and Institutional News.

PMID- 29820171
TI  - The Alterations at the Royal Berkshire Hospital.

PMID- 29820172
TI  - A Housekeeper's Criticisms on Food by Contract.

PMID- 29820173
TI  - The Recovery Rate in Mental Hospitals.

PMID- 29820175
TI  - The Question of Senior Partnership.

PMID- 29820174
TI  - Enteric Fever.-II.

PMID- 29820176
TI  - The Institutional Worker.

PMID- 29820177
TI  - Mount Vernon Hospital and the Case for Paying Consumptives.

PMID- 29820179
TI  - The York County Hospital.

PMID- 29820178
TI  - An Independent and Public Enquiry Called for.

PMID- 29820180
TI  - The Organisation of the British Red Cross Hospitals in Turkey.

PMID- 29820182
TI  - Ireland and Medical Benefit.

PMID- 29820181
TI  - Bennett's Fracture.

PMID- 29820183
TI  - Hospital and Institutional News.

PMID- 29820184
TI  - Laboratory Methods in Relation to Tuberculosis.

PMID- 29820186
TI  - Adenoid Disease in School Children.

PMID- 29820185
TI  - The Treatment of Tuberculosis.

PMID- 29820187
TI  - Expenses of Administration.

PMID- 29820188
TI  - The Work of the New County Council.

PMID- 29820189
TI  - Tuberculosis Hospital & Sanatorium Construction: Inexpensive Buildings for
      Tuberculosis Patients.

PMID- 29820190
TI  - A Hospital in the Making.

PMID- 29820191
TI  - The Institutional Worker.

PMID- 29820192
TI  - Motor Hysteria.

PMID- 29820193
TI  - Nervous Diseases.

PMID- 29820194
TI  - Graduate Teaching Facilities in London Hospitals: National Hospital for
      Paralysis, Queen Square, Bloomsbury.

PMID- 29820195
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29820196
TI  - Current Hospital Topics.

PMID- 29820197
TI  - Medical Opinion and Movement.

PMID- 29820198
TI  - Diseases of the Blood.

PMID- 29820200
TI  - Annotations.

PMID- 29820199
TI  - Carcinoma.

PMID- 29820201
TI  - "The Hospital" Nursing Section.

PMID- 29820202
TI  - Some Cancer Studies.

PMID- 29820203
TI  - X-Rays.

PMID- 29820204
TI  - The Treatment of Ringworm of the Scalp.

PMID- 29820206
TI  - Medical Opinion and Movement.

PMID- 29820205
TI  - The Cost of Lunacy.

PMID- 29820207
TI  - Hospital Meetings.

PMID- 29820208
TI  - Annotations.

PMID- 29820209
TI  - Cerebral Symptoms and Haemoptysis in Pneumonia.

PMID- 29820211
TI  - "The Hospital" Nursing Section.

PMID- 29820210
TI  - Fractures in the Vicinity of the Elbow-Joint.

PMID- 29820213
TI  - King Edward VII. Sanatorium: Opening by the King.

PMID- 29820212
TI  - Tinned and Preserved Foods: Difficulties, Poisoning, and a Moral.

PMID- 29820215
TI  - Comparative Medicine.

PMID- 29820214
TI  - Current Hospital Topics.

PMID- 29820216
TI  - Remedies and Their Uses.

PMID- 29820217
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29820218
TI  - The Prevention of Trade Accidents.

PMID- 29820219
TI  - Hospital Meetings.

PMID- 29820220
TI  - Annotations.

PMID- 29820221
TI  - House and Office Heating.

PMID- 29820222
TI  - "The Hospital" Nursing Section.

PMID- 29820223
TI  - Local Anaesthesia in General Surgery.

PMID- 29820224
TI  - Military Sanitation.

PMID- 29820225
TI  - The Present Position of Radiation in Treatment: III. X-Rays.

PMID- 29820226
TI  - Current Hospital Topics.

PMID- 29820227
TI  - Aids to Poor Sufferers: Some Invalid Contrivances.

PMID- 29820228
TI  - Wanted: Annual Subscriptions.

PMID- 29820229
TI  - Practical Notes on Remedies.

PMID- 29820230
TI  - The Royal Infirmary, Liverpool.

PMID- 29820231
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29820232
TI  - Medical Opinion and Movement.

PMID- 29820233
TI  - Current Hospital Topics.

PMID- 29820234
TI  - New Appliances and Things Medical.

PMID- 29820235
TI  - Structural and Practical Departments.

PMID- 29820236
TI  - Hospital Meetings.

PMID- 29820238
TI  - Additions to the Victoria Infirmary, Glasgow.

PMID- 29820237
TI  - Medical Opinion and Movement.

PMID- 29820239
TI  - Annotations.

PMID- 29820240
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29820241
TI  - Patent Medicines.

PMID- 29820242
TI  - University College Hospital.

PMID- 29820243
TI  - Practical Notes on Remedies.

PMID- 29820244
TI  - The British Medical Association and the General Medical Council.

PMID- 29820246
TI  - "The Hospital" Nursing Section.

PMID- 29820245
TI  - The Present Position of Radiation in Treatment: II. Finsen Light.

PMID- 29820247
TI  - Purulent Pleurisy.

PMID- 29820248
TI  - New Appliances and Things Medical.

PMID- 29820249
TI  - Vaccination in Germany.-How Compulsion Is Managed.

PMID- 29820250
TI  - Diphtheria.

PMID- 29820251
TI  - "The Hospital" Nursing Mirror.

PMID- 29820252
TI  - Progress in State Medicine.

PMID- 29820253
TI  - Institutional Questions.

PMID- 29820254
TI  - The Lunatic at Large.

PMID- 29820255
TI  - Aseptic Vaccination in New York.

PMID- 29820257
TI  - Sympathetic Ophthalmia.

PMID- 29820256
TI  - Progress in Surgery.

PMID- 29820258
TI  - Skin Grafting.

PMID- 29820259
TI  - At What Age to Operate for Squint.

PMID- 29820260
TI  - Annotations.

PMID- 29820261
TI  - Hospital Construction.

PMID- 29820262
TI  - Modern Sociology.

PMID- 29820263
TI  - Notes and News.

PMID- 29820264
TI  - Field Surgery in South Africa.

PMID- 29820265
TI  - Notes.

PMID- 29820266
TI  - Free Spectacles for Children in Public Schools.

PMID- 29820267
TI  - Special Analytical and Health Commission on Tinned and Preserved Food: V. Canned
      Meats.

PMID- 29820269
TI  - The Medical Inspection of Scholars.

PMID- 29820268
TI  - Some Remarks on the Diagnosis and Complications of Diphtheria.

PMID- 29820270
TI  - Leucocytosis after Operations.

PMID- 29820271
TI  - Annotations.

PMID- 29820272
TI  - Structural and Practical Departments.

PMID- 29820273
TI  - Social and Poor-Law Problems.

PMID- 29820274
TI  - New Sanitary Wing at the Boston Hospital.

PMID- 29820275
TI  - A Plea for the Eye.

PMID- 29820277
TI  - "The Hospital" Nursing Section.

PMID- 29820276
TI  - An Ideal Health Resort.

PMID- 29820279
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29820278
TI  - Graduate Teaching Facilities in London Hospitals: Central London Hospital for
      Diseases of the Throat, Ear, and Nose.

PMID- 29820280
TI  - Medical Opinion and Movement.

PMID- 29820281
TI  - Current Hospital Topics.

PMID- 29820282
TI  - The York County Hospital.

PMID- 29820284
TI  - The Mortury Unit: Different Type Compared.

PMID- 29820283
TI  - The Use of Tuberculin in Poor-Law Infirmaries.

PMID- 29820285
TI  - Assassination and "Militantism."

PMID- 29820286
TI  - The Curious History of L'Hotel-Dieu De Paris: II. The Accommodation for Patients.

PMID- 29820288
TI  - Research and Remedies.

PMID- 29820287
TI  - Surgical Operations and the Workmen's Compensation Act.

PMID- 29820290
TI  - Mr. George Butchart, Chairman of the House Committee.

PMID- 29820289
TI  - The Surgical Treatment of Obesity.

PMID- 29820291
TI  - The Technique of the Artificial Pneumothorax Treatment of Consumption.

PMID- 29820292
TI  - The Editor's Letter-Box.

PMID- 29820293
TI  - The London Hospitals of Earlier Days.

PMID- 29820294
TI  - Hospital and Institutional News.

PMID- 29820295
TI  - An Excellent Type for the Small General Hospital.

PMID- 29820296
TI  - The Living-Out System at Leavesden: Dr. F. A. Elkins on the Theory and Practice
      of the Scheme.

PMID- 29820297
TI  - The Institutional Worker.

PMID- 29820298
TI  - Institutional Needs.

PMID- 29820299
TI  - Villous Papilloma of the Rectum.

PMID- 29820300
TI  - A Test Case and Its Issues.

PMID- 29820301
TI  - The Editor's Letter-Box.

PMID- 29820302
TI  - Panel Servitude without Anaesthetics.

PMID- 29820303
TI  - The Institutional Worker.

PMID- 29820304
TI  - Government (Teaching) and Municipal (Non-Teaching) Hospitals : II. The Present
      Position of Hospitals in Germany.

PMID- 29820305
TI  - Nursing Homes and Our "Approved Homes".

PMID- 29820306
TI  - Diet in the Second Year of Life.

PMID- 29820307
TI  - Hospital Resources in the Eastern War.

PMID- 29820309
TI  - Hospital Needs.

PMID- 29820308
TI  - The Medical Management of Consumptives.

PMID- 29820311
TI  - Pain and Medical Research.

PMID- 29820310
TI  - Elegant Prescriptions.

PMID- 29820312
TI  - Unemployment Insurance.

PMID- 29820314
TI  - Hospital and Institutional News.

PMID- 29820313
TI  - Enteric Fever.

PMID- 29820315
TI  - The Old and the New: A Comparison in Out-Patient Departments.

PMID- 29820316
TI  - Research and Remedies.

PMID- 29820318
TI  - Meals with Less Meat.

PMID- 29820317
TI  - Sanatoria and Landscape Architecture.

PMID- 29820319
TI  - The New South London Hospital for Women.

PMID- 29820320
TI  - Legal Notes for Institutional Workers.

PMID- 29820321
TI  - Mental Hospitals for Incurable Patients.

PMID- 29820322
TI  - The Doctor and His Work.

PMID- 29820323
TI  - The Royal Society of Medicine.

PMID- 29820324
TI  - Keeping the Feast at Salisbury Infirmary.

PMID- 29820325
TI  - Self-Help in Institutional Economy: III. Do Hospital Dairies Pay?

PMID- 29820326
TI  - Fulham Infirmary.

PMID- 29820327
TI  - The Christmas Choirs at Cardiff.

PMID- 29820328
TI  - Hospital and Institutional News.

PMID- 29820329
TI  - Christmas at the London, 1912.

PMID- 29820330
TI  - Meeting at St. Bartholomew's Hospital.

PMID- 29820331
TI  - The Art of Decorating Wards.

PMID- 29820332
TI  - Christmas in a "Wessex" County Hospital.

PMID- 29820333
TI  - The Cinematograph at Charing Cross Hospital.

PMID- 29820334
TI  - "The Play's the Thing" at Bath.

PMID- 29820335
TI  - Elizabethan Decorations at the Gravesend Hospital.

PMID- 29820336
TI  - Dispensing and the Insurance Act: The Future of Pharmacy.

PMID- 29820337
TI  - An Isolation Hospital's Ideas.

PMID- 29820338
TI  - Christmas 1912 at Cambridge.

PMID- 29820339
TI  - In a Bulgarian Hospital.

PMID- 29820340
TI  - Christmas under Difficulties at Chichester.

PMID- 29820341
TI  - The Bar of History: "The Hospital's" Review of 1912.

PMID- 29820342
TI  - At a London Children's Hospital.

PMID- 29820344
TI  - The Aim and Working of a Festivities Fund: A Lesson from the Warrington
      Infirmary.

PMID- 29820343
TI  - A Sanatorium Christmas in the North.

PMID- 29820346
TI  - Soils and Sanitation.

PMID- 29820345
TI  - Christmas in a Yorkshire Cottage Hospital.

PMID- 29820347
TI  - Hospital Porters and Solicitors' Touts.

PMID- 29820348
TI  - What Is a Major Operation?

PMID- 29820349
TI  - With Daffodil and Dragon at Walthamstow.

PMID- 29820350
TI  - The Play at West Norfolk and Lynn Hospital.

PMID- 29820351
TI  - A Fortnight's Festivities at Leicester.

PMID- 29820352
TI  - The Institutional Worker.

PMID- 29820353
TI  - Christmas at the National Sanatorium.

PMID- 29820354
TI  - Disease of the Lungs.

PMID- 29820355
TI  - Progress in Surgery.

PMID- 29820356
TI  - The Subcutaneous Injection of Quinine.

PMID- 29820357
TI  - Inflammable Celluloid.

PMID- 29820358
TI  - Hospitals with Special Acts of Parliament.

PMID- 29820359
TI  - Epistaxis in Rheumatism in Children.

PMID- 29820360
TI  - Notes and News.

PMID- 29820361
TI  - Annotations.

PMID- 29820362
TI  - Infantile Scurvy and "Sterilised" Milk.

PMID- 29820363
TI  - Hospital Meetings.

PMID- 29820364
TI  - What to Do with the Appendix.

PMID- 29820365
TI  - The Hospital. Nursing Section.

PMID- 29820366
TI  - University Matriculation.

PMID- 29820367
TI  - The Story of the Insane from Year to Year.

PMID- 29820368
TI  - A Clinical Lecture on Spasmodic Dysmenorrhoea.

PMID- 29820369
TI  - Progress in Bacteriology.

PMID- 29820370
TI  - Hospital Expenditure.-I.

PMID- 29820372
TI  - Night Terrors and Nightmares.

PMID- 29820371
TI  - New Appliances and Things Medical.

PMID- 29820373
TI  - The Superficial Form of Rodent Ulcer.

PMID- 29820374
TI  - New Appliances and Things Medical.

PMID- 29820376
TI  - The Liabilities for the Treatment of Pay Patients in Hospitals.

PMID- 29820375
TI  - Notes and News.

PMID- 29820377
TI  - A Single-Handed Operation.

PMID- 29820378
TI  - Annotations.

PMID- 29820379
TI  - The Causes of Cough in Children.

PMID- 29820380
TI  - A New and Safe Method of Delivery in Placenta Praevia.

PMID- 29820381
TI  - Notes.

PMID- 29820382
TI  - Tuberculosis as Discussed at Portsmouth.

PMID- 29820383
TI  - Progress in Medicine.

PMID- 29820385
TI  - The Poor Laws.

PMID- 29820384
TI  - Modern Sociology.

PMID- 29820386
TI  - Infectious Cases in General Hospitals.

PMID- 29820387
TI  - Progress in Surgery.

PMID- 29820388
TI  - Editor's Letter-Box.

PMID- 29820389
TI  - The Treatment of Cervical Adenitis.

PMID- 29820391
TI  - "The Hospital" Nursing Mirror.

PMID- 29820390
TI  - A Plea for Speed in Operating.

PMID- 29820393
TI  - The Story of the Insane from Year to Year.

PMID- 29820392
TI  - Institutional Questions.

PMID- 29820394
TI  - Progress in Gynaecology.

PMID- 29820395
TI  - The Malaria Problem.

PMID- 29820396
TI  - Notes and News.

PMID- 29820397
TI  - Annotations.

PMID- 29820399
TI  - New Appliances and Things Medical.

PMID- 29820398
TI  - Hospital Construction.

PMID- 29820400
TI  - Progress in Surgery.

PMID- 29820401
TI  - "The Hospital" Nursing Mirror.

PMID- 29820402
TI  - Vaccination and Small-Pox in the United States Army.

PMID- 29820403
TI  - Notes.

PMID- 29820405
TI  - Autumnal Diarrhoea.

PMID- 29820404
TI  - The North-Western Fever Hospital.

PMID- 29820406
TI  - Notes on Health Resorts.

PMID- 29820407
TI  - The Chelsea Workhouse Infirmary.

PMID- 29820408
TI  - Conservative Gynaecology.

PMID- 29820409
TI  - Gunshot Wounds of the Abdomen.

PMID- 29820411
TI  - Progress in Gynaecology.

PMID- 29820410
TI  - Lumbar Puncture.

PMID- 29820412
TI  - The Serum Treatment of Fever after Delivery.

PMID- 29820413
TI  - Disease and Insanity.

PMID- 29820414
TI  - The Story of the Insane from Year to Year.

PMID- 29820415
TI  - Progress in Medicine.

PMID- 29820417
TI  - The Voluntary Hospitals and the Government: the Gist of the Matter.

PMID- 29820416
TI  - The Present Difficulties of Clinical Pathology: Divided Responsibility or
      Laboratory Beds?

PMID- 29820419
TI  - The Rise of Clinical Pathology.

PMID- 29820418
TI  - The Institutional Worker.

PMID- 29820420
TI  - A Staff Question at Cardiff.

PMID- 29820421
TI  - CO2 Fire Extincteurs.

PMID- 29820423
TI  - King Edward's Hospital Fund for London: The Speaker on a Diminishing Charitable
      Public.

PMID- 29820422
TI  - Anti-English Feeling in Greece.

PMID- 29820424
TI  - Self-Help in Institutional Economy: II. The Meat Supply: A Suggestion.

PMID- 29820425
TI  - Southwark Guardians and "The Hospital."

PMID- 29820426
TI  - The Teaching of Operative Surgery.

PMID- 29820427
TI  - The Poor, Our Voluntary Hospitals and Nurses.

PMID- 29820429
TI  - Christmas Festivities: Their Helpfulness and Injustice.

PMID- 29820428
TI  - The League of Mercy.

PMID- 29820430
TI  - Research and Remedies.

PMID- 29820431
TI  - A Christmas "Caution."

PMID- 29820432
TI  - Remember the Poor.

PMID- 29820433
TI  - Hospital and Institutional News.

PMID- 29820434
TI  - Annotations.

PMID- 29820435
TI  - Everybody's Page.

PMID- 29820436
TI  - Gonorrhoeal Arthritis, Gout and Rheumatoid Arthritis.

PMID- 29820437
TI  - The Etiology of Empyema.

PMID- 29820438
TI  - The Consumers' League.

PMID- 29820439
TI  - London's Great Problems: North Kensington Friendly Workers.

PMID- 29820440
TI  - The Relation of Lupus to Tubercle.

PMID- 29820442
TI  - Cambridge University Medical Society.

PMID- 29820441
TI  - Special Preachers.

PMID- 29820443
TI  - Salt as an Antiseptic.

PMID- 29820444
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29820446
TI  - Surgical Treatment of Tuberculous Peritonitis.

PMID- 29820445
TI  - The Tomato and Cancer.

PMID- 29820448
TI  - Lysol.

PMID- 29820447
TI  - Notes and News.

PMID- 29820449
TI  - The Infirmary Medical Superintendents' Society.

PMID- 29820450
TI  - Intubation in Diphtheria.

PMID- 29820451
TI  - Action of Salol on the Kidneys.

PMID- 29820452
TI  - Jenner, Pasteur, and Koch.

PMID- 29820454
TI  - Addenbrooke's Hospital.

PMID- 29820453
TI  - The Press and the Hospitals.

PMID- 29820455
TI  - Notes and News.

PMID- 29820456
TI  - The Hospital. Nursing Section.

PMID- 29820457
TI  - Surgery in Heart Disease.

PMID- 29820458
TI  - The Story of the Insane from Year to Year.

PMID- 29820459
TI  - Annotations.

PMID- 29820460
TI  - Ichthyol in Skin Diseases.

PMID- 29820461
TI  - Fourth Disease.

PMID- 29820462
TI  - Co-Operative Research.

PMID- 29820464
TI  - Progress in Disease of Digestive Organs.

PMID- 29820463
TI  - Modern Methods of Vaccination.

PMID- 29820465
TI  - Circumcision for the Relief of Acne.

PMID- 29820466
TI  - Progress in Fevers.

PMID- 29820468
TI  - Modern Sociology.

PMID- 29820467
TI  - Progress in State Medicine.

PMID- 29820469
TI  - Beef Tea and Meat Preparations: IV. The Economy of Meat Extracts and
      Preparations.

PMID- 29820470
TI  - Glances at the Hospitals.

PMID- 29820471
TI  - The Small-Pox Panic.

PMID- 29820472
TI  - Isolation Hospitals.

PMID- 29820473
TI  - The Other Side of the Vaccination Question.

PMID- 29820474
TI  - Medical Opinion and Movement.

PMID- 29820475
TI  - Physical Culture and Spinal Curvature.

PMID- 29820476
TI  - St. George's Hospital.

PMID- 29820477
TI  - Remedies and Their Uses.

PMID- 29820478
TI  - Treatment at Health Resorts.

PMID- 29820479
TI  - Current Hospital Topics.

PMID- 29820480
TI  - The King Edward VII. Sanatorium.

PMID- 29820481
TI  - St. Thomas's Hospital Medical School.

PMID- 29820482
TI  - Annotations.

PMID- 29820483
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29820484
TI  - Special Analytical and Health Commission on Tinned and Preserved Food: II.
      Preserved Meat Foods Prepared in England.

PMID- 29820485
TI  - St. Thomas's Hospital and Medical School: Professor Osler, M.D., F.R.S., on its
      Work.

PMID- 29820487
TI  - New Appliances and Things Medical.

PMID- 29820486
TI  - Structural and Practical Departments.

PMID- 29820488
TI  - Metropolitan Hospital.

PMID- 29820489
TI  - Teaching Men How to Live.

PMID- 29820490
TI  - Hospital Appeals and Hospital Abuse.

PMID- 29820491
TI  - "The Hospital" Nursing Section.

PMID- 29820493
TI  - Northerner v. Southerner.

PMID- 29820492
TI  - On the Practical Value of the Corneal Reflex in Examining the Eyes of Children.

PMID- 29820494
TI  - Annotations.

PMID- 29820495
TI  - Everybody's Page.

PMID- 29820496
TI  - Hospitals from a Statistical Point of View.

PMID- 29820497
TI  - A Hospital Garden.

PMID- 29820498
TI  - The History and Capabilities of Herbal Simples: XXIV.-Cress.

PMID- 29820499
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29820500
TI  - The Poor Man's Christmas.

PMID- 29820502
TI  - Working Women in Large Towns: XVIII. Aids for Working Women.

PMID- 29820501
TI  - The Convulsive Cough of Puberty.

PMID- 29820504
TI  - Charity's Much-Injured Name.

PMID- 29820503
TI  - Sussex County Hospital.

PMID- 29820505
TI  - The Physical Diagnosis of Diseases of the Lungs and Pleura.

PMID- 29820506
TI  - Notes and News.

PMID- 29820507
TI  - Clap-Trap Criticism.

PMID- 29820508
TI  - House Ventilation and Warming.

PMID- 29820509
TI  - Starving.

PMID- 29820510
TI  - The Story of the Insane from Year to Year.

PMID- 29820511
TI  - Manual Training in Schools: II. In America, Sweden, and France.

PMID- 29820512
TI  - Thanksgiving.

PMID- 29820513
TI  - Starvation in Enteric Fever.

PMID- 29820514
TI  - Curability of Hepatic Cirrhosis by Iodide of Potassium and Jaborandi.

PMID- 29820515
TI  - Working Women in Large Towns: XII. Economic Aspects of the Subject.

PMID- 29820516
TI  - Are Lady Doctors Clever?

PMID- 29820517
TI  - Notes and News.

PMID- 29820518
TI  - Resection of the Liver.

PMID- 29820519
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29820520
TI  - A Celebrated Matron.

PMID- 29820522
TI  - Death from Burns.

PMID- 29820521
TI  - The Administrative Advance.

PMID- 29820524
TI  - October.

PMID- 29820523
TI  - Thyroid Grafting.

PMID- 29820525
TI  - Annotations.

PMID- 29820526
TI  - Saline Subcutaneous Injections.

PMID- 29820527
TI  - The Hospital Movement in the United States: The McLean Hospital for the Insane at
      Waverley.

PMID- 29820528
TI  - Portugal as a Holiday and Health Resort.

PMID- 29820530
TI  - Haemorrhagic Pancreatitis.

PMID- 29820529
TI  - Current Hospital Topics.

PMID- 29820531
TI  - Annotations.

PMID- 29820532
TI  - "The Hospital" Nursing Section.

PMID- 29820533
TI  - Ataxia in Childhood.

PMID- 29820534
TI  - New Appliances and Things Medical.

PMID- 29820536
TI  - Carcinoma.

PMID- 29820535
TI  - Diseases of the Digestive Organs.

PMID- 29820537
TI  - Pharmacopoeial Doses.

PMID- 29820538
TI  - Special Societies and the Amalgamation Scheme.

PMID- 29820539
TI  - John Banister: The Troubles of a Seventeenth Century Oculist.

PMID- 29820540
TI  - Physical Deterioration.

PMID- 29820542
TI  - North-Eastern Hospital for Children.

PMID- 29820541
TI  - The Prognosis in a Case of Cerebral Haemorrhage.

PMID- 29820543
TI  - A Central School of Medicine for London.

PMID- 29820544
TI  - Prognosis in Albuminuric Retinitis.

PMID- 29820546
TI  - Inebriates.

PMID- 29820545
TI  - Fourth Disease.

PMID- 29820547
TI  - The Health of London.

PMID- 29820548
TI  - The Legislation of 1902.

PMID- 29820549
TI  - Annotations.

PMID- 29820550
TI  - Progress in Disease of Digestive Organs.

PMID- 29820551
TI  - Glances at the Hospitals.

PMID- 29820552
TI  - Yellow Fever: Precautions to Be Taken in Countries Where It Is Prevalent.

PMID- 29820553
TI  - Prince of Wales's Hospital Fund for London.

PMID- 29820554
TI  - The Story of the Insane from Year to Year.

PMID- 29820555
TI  - Life Saving in the London Streets.

PMID- 29820556
TI  - The Essentials of Sanatorium Treatment.

PMID- 29820557
TI  - Progress in State Medicine.

PMID- 29820559
TI  - The Hospital. Nursing Section.

PMID- 29820558
TI  - Modern Sociology.

PMID- 29820561
TI  - Notes and News.

PMID- 29820560
TI  - Progress in Pediatrics.

PMID- 29820562
TI  - Unemployment Insurance.

PMID- 29820563
TI  - Government (Teaching) and Municipal (Non-Teaching) German Hospitals : V. The
      Growing Cost of State Hospitals and its Consequences.

PMID- 29820564
TI  - The Voluntary Hospitals and Insured Persons.

PMID- 29820565
TI  - The North Wimbledon Hospital.

PMID- 29820566
TI  - The British Red Cross Society and the Balkan War: The Staffing, Pay, and
      Equipment of the Units.

PMID- 29820567
TI  - The Differential Diagnosis of Intestinal Haemorrhage: Some Symptoms of
      Obstruction and Disease.

PMID- 29820568
TI  - Some Interesting Institutions.

PMID- 29820569
TI  - The Institutional Worker.

PMID- 29820571
TI  - Paulus AEgineta: Four Examples of His Skill.

PMID- 29820570
TI  - Circumcision in Girls.

PMID- 29820572
TI  - Institutional Housekeeping.

PMID- 29820574
TI  - The Royal Free Hospital's New Out-Patient Department.

PMID- 29820573
TI  - Powers of Insurance Committees.

PMID- 29820576
TI  - The Huxley Lecture and Charing Cross Hospital Dinner.

PMID- 29820575
TI  - Hospital and Institutional News.

PMID- 29820577
TI  - Hedonal and Its Limitations.

PMID- 29820578
TI  - Fluoroscopy and Radiography.

PMID- 29820579
TI  - Graduate Teaching Facilities in London Hospitals.

PMID- 29820580
TI  - Annotations.

PMID- 29820581
TI  - Medical Opinion and Movement.

PMID- 29820582
TI  - New Workhouse Infirmary at Stepping Hill, Stockport.

PMID- 29820584
TI  - The Relation of Insanity to Civilisation.-III.

PMID- 29820583
TI  - New Appliances and Things Medical.

PMID- 29820585
TI  - Special Analytical and Health Commission on Tinned and Preserved Food: Sweetness
      and Sugar.

PMID- 29820586
TI  - "The Hospital" Nursing Section.

PMID- 29820587
TI  - Remedies and Their Uses.

PMID- 29820588
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29820589
TI  - Notes on Liquid Articles of Dietary.

PMID- 29820590
TI  - Intestinal Parasites.

PMID- 29820591
TI  - Bakers' Exhibition.

PMID- 29820592
TI  - The Story of the Insane from Year to Year.

PMID- 29820593
TI  - School Diseases-Preventable, but Not Prevented.

PMID- 29820594
TI  - Professor Behring's "Tulase"-New Remedy for Consumption.

PMID- 29820596
TI  - Psoriasis.

PMID- 29820595
TI  - Spastic Constipation.

PMID- 29820597
TI  - Notes and News.

PMID- 29820598
TI  - Speyer Prize Competition.

PMID- 29820599
TI  - Practical Departments.

PMID- 29820600
TI  - The Hospital Special Analytical Commission on Whisky.

PMID- 29820601
TI  - Spirochaeta Pallida of Schaudiun.

PMID- 29820602
TI  - Daily Practice and Clinical Expert Teaching.

PMID- 29820603
TI  - The Growth of Hospital Expenditure Considered in Relation to Greater London.

PMID- 29820604
TI  - New Appliances and Things Medical.

PMID- 29820605
TI  - Hospital Meetings.

PMID- 29820607
TI  - Annotations.

PMID- 29820608
TI  - "The Hospital" Nursing Section.

PMID- 29820606
TI  - Pay Pavilions of General Hospitals.

PMID- 29820609
TI  - The Facial Aspect in Diseases of Children.

PMID- 29820610
TI  - League of Mercy.

PMID- 29820611
TI  - King Edward's Hospital Fund for London.

PMID- 29820612
TI  - Preventable Social Ills: Prevention as a New Art.

PMID- 29820613
TI  - The Institutional Worker.

PMID- 29820614
TI  - The Cape Hospital Ordinance.

PMID- 29820615
TI  - Lord Crewe on National Insurance and the Voluntary Hospitals: Opening of the New
      Wing at Beckett Hospital, Barnsley.

PMID- 29820617
TI  - The Case against Provisional Arrangements.

PMID- 29820616
TI  - Hospital and Institutional News.

PMID- 29820619
TI  - An Extraordinary Case of Brain Surgery.

PMID- 29820618
TI  - The Care of Rheumatic Children: Particularly of Those with Heart Disease and
      Chorea.

PMID- 29820621
TI  - The Central Hospital Council for London.

PMID- 29820620
TI  - The Sphere of Institutional Treatment: The "Wretched Life" of Pit Doctors.

PMID- 29820622
TI  - Is the Race Decaying?

PMID- 29820623
TI  - The Payment of Benefits.

PMID- 29820624
TI  - Hospital Regulations and the Insurance Act.

PMID- 29820625
TI  - Hospital Almoners and Insured Patients.

PMID- 29820626
TI  - Self-Help in Institutional Economy: IV. Hospital Gardening and the Supply of
      Vegetables.

PMID- 29820627
TI  - The Care of Rheumatic Children.

PMID- 29820629
TI  - The Arts of the Theatre at Fulham Infirmary: A Remarkable Example of Rehearsing
      and Staging.

PMID- 29820628
TI  - The Editor's Letter-Box.

PMID- 29820630
TI  - Institutional Needs.

PMID- 29820631
TI  - L'Hopital De La Charite De Paris.

PMID- 29820632
TI  - Social and Poor-Law Problems.

PMID- 29820633
TI  - "The Hospital" Nursing Section.

PMID- 29820634
TI  - Special Analytical and Health Commission on Tinned and Preserved Food: IV.
      Preserved Foods Consisting Largely of Fat.

PMID- 29820635
TI  - An Appeal for the Child.

PMID- 29820637
TI  - Graduate Teaching Facilities in London Hospitals: Seamen's Hospital
      (Dreadnought), Greenwich: The London School of Clinical Medicine.

PMID- 29820636
TI  - Current Hospital Topics.

PMID- 29820638
TI  - Medical Opinion and Movement.

PMID- 29820639
TI  - Opening of the Royal Victoria-Infirmary, Newcastle.

PMID- 29820641
TI  - The Compulsory Notification of Tuberculosis.

PMID- 29820640
TI  - Irregularities of the Heart.

PMID- 29820642
TI  - Cerebro-Spinal Meningitis in Great Britain.

PMID- 29820643
TI  - Annotations.

PMID- 29820644
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29820645
TI  - Remedies and Their Uses.

PMID- 29820646
TI  - By the Way.

PMID- 29820647
TI  - Curiosities of Cancer: Two Cases of Extraordinary Duration.

PMID- 29820648
TI  - The Bad Case of the Baker.

PMID- 29820649
TI  - Cardiff Hospital and Viscount Tredegar.

PMID- 29820650
TI  - The Home Hospitals Association.

PMID- 29820651
TI  - Compensated Accidents.

PMID- 29820652
TI  - Research and Remedies.

PMID- 29820653
TI  - Institutional Needs.

PMID- 29820654
TI  - Hospital and Institutional News.

PMID- 29820655
TI  - Gastric Surgery in Institutional Treatment.

PMID- 29820656
TI  - The Institutional Worker.

PMID- 29820657
TI  - The Poor-Law Infirmary: II. Fire Risks in Infirmaries-Neglected Precautions.

PMID- 29820658
TI  - The Departmental Report on Tuberculosis.

PMID- 29820659
TI  - British Hospitals & National Insurance: Sir Henry Burdett Outlines a New Scheme
      of Co-Operation.

PMID- 29820660
TI  - A New Invalid Dress.

PMID- 29820661
TI  - Disease of the Pancreas.

PMID- 29820662
TI  - Mental Derangement and Outward Surroundings.

PMID- 29820664
TI  - A Hint for British Artists.

PMID- 29820663
TI  - Pugilistic Science.

PMID- 29820666
TI  - Manual Training in Schools: I. Its Use and Abuse.

PMID- 29820665
TI  - There and Back.

PMID- 29820668
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29820669
TI  - Deglutitio Impedita.

PMID- 29820667
TI  - Death Certificates and Murder.

PMID- 29820670
TI  - Notes and News.

PMID- 29820671
TI  - The C.O.S.'s Protest.

PMID- 29820672
TI  - Props and Buttresses.

PMID- 29820673
TI  - Annotations.

PMID- 29820674
TI  - No Gentleman Keeps a Bull Dog.

PMID- 29820676
TI  - The Story of the Insane from Year to Year.

PMID- 29820675
TI  - Everybody's Page.

PMID- 29820678
TI  - The History and Capabilities of Herbal Simples: XX.-Club Moss.

PMID- 29820677
TI  - Loneliness.

PMID- 29820679
TI  - Hospital Meetings, &c.

PMID- 29820680
TI  - Legal Intelligence.

PMID- 29820681
TI  - Arthrotomy for the Relief of Pain.

PMID- 29820682
TI  - The Urine and the Faeces as Vehicles of Typhoid Infection.

PMID- 29820684
TI  - Notes and News.

PMID- 29820683
TI  - Some Facts Concerning Marriage in the Case of Woman.

PMID- 29820685
TI  - The After-Care Association for the Insane.

PMID- 29820686
TI  - Song Birds as a Source of Tuberculosis.

PMID- 29820688
TI  - Pseudo-Tuberculosis.

PMID- 29820687
TI  - Progress in Toxicology.

PMID- 29820689
TI  - The Troubles of the Masseuses.

PMID- 29820690
TI  - Editor's Letter-Box.

PMID- 29820691
TI  - Right Colotomy for Chronic Colitis.

PMID- 29820692
TI  - The Cure of Consumption.

PMID- 29820693
TI  - Modern Sociology.

PMID- 29820694
TI  - The Choice of a Health Resort.

PMID- 29820695
TI  - New Appliances and Things Medical.

PMID- 29820696
TI  - Progress in Surgery.

PMID- 29820698
TI  - Progress in Medicine.

PMID- 29820697
TI  - The Medical, Surgical, and Hygienic Exhibition.

PMID- 29820700
TI  - "The Hospital" Nursing Mirror.

PMID- 29820699
TI  - Annotations.

PMID- 29820701
TI  - Scotch Cottage Hospital Movement.

PMID- 29820702
TI  - The Editor's Letter-Box.

PMID- 29820703
TI  - Hospitals and Insured Patients.

PMID- 29820704
TI  - The Prevention of Fire.

PMID- 29820706
TI  - The Prevention of Fire.

PMID- 29820705
TI  - The Editor's Letter-Box.

PMID- 29820707
TI  - Poor-Law Infirmaries and Voluntary Hospitals: Co-Operation in the Treatment of
      the Sick.

PMID- 29820708
TI  - Architectural Designs in Maddox Street: Some Tendencies of Institutional
      Planning.

PMID- 29820709
TI  - Preventable Social Ills.

PMID- 29820710
TI  - Institutional Needs.

PMID- 29820711
TI  - The Care of Rheumatic Children.

PMID- 29820712
TI  - Baking Bread in a Steam Oven.

PMID- 29820713
TI  - The Sphere of Institutional Treatment: III. Medical Attendance on a Collectivist
      Basis.

PMID- 29820714
TI  - The X-Rays.

PMID- 29820715
TI  - Hospital and Institutional News.

PMID- 29820716
TI  - The Behaviour of Diphtheria in Schools.

PMID- 29820717
TI  - The Institutional Worker.

PMID- 29820718
TI  - Panel Practitioners and Hospital Beds.

PMID- 29820719
TI  - Self-Help in Institutional Economy: V. The Co-Operative Laundry.

PMID- 29820720
TI  - Freedom of Speech at St. Bartholomew's Hospital.

PMID- 29820721
TI  - The Housing of Staffs in Mental Hospitals.

PMID- 29820722
TI  - Maternity Benefit in Intention and Fact.

PMID- 29820724
TI  - An Institutional Celebrity's Birthday.

PMID- 29820723
TI  - The Clinical Laboratory: II. Diseases Due to Bacterial Infections.

PMID- 29820725
TI  - Working Women in Large Towns: XVI. Social, Moral, and Physical Aspects of the
      Subject.

PMID- 29820726
TI  - Pensions for Hospital Workers.-I.

PMID- 29820727
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29820728
TI  - A New Champion of Medical Women's Rights.

PMID- 29820730
TI  - Mr. Besant on Drunkenness.

PMID- 29820729
TI  - The History and Capabilities of Herbal Simples: XXIII.-Cowslip.

PMID- 29820731
TI  - Pathology.

PMID- 29820732
TI  - Notes and News.

PMID- 29820733
TI  - Koch's Cure: Its Nature and Its Limits.

PMID- 29820734
TI  - Medical Syndicates.

PMID- 29820736
TI  - Everybody's Page.

PMID- 29820735
TI  - Annotations.

PMID- 29820737
TI  - Tubercular Affection of the Larynx.

PMID- 29820738
TI  - Dr. Koch on Tuberculosis.

PMID- 29820739
TI  - Remedies and Their Uses.

PMID- 29820740
TI  - Ringworm and Its Cure.

PMID- 29820742
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29820741
TI  - The Uniform System of Accounts.

PMID- 29820743
TI  - Annotations.

PMID- 29820744
TI  - New Appliances and Things Medical.

PMID- 29820745
TI  - Harrogate and Knaresborough Isolation Hospital.

PMID- 29820746
TI  - Social and Poor Law Problems.

PMID- 29820747
TI  - Spectacles through Charity for School-Children.

PMID- 29820748
TI  - "The Hospital" Nursing Section.

PMID- 29820749
TI  - Hospital Meetings.

PMID- 29820751
TI  - Current Hospital Topics.

PMID- 29820750
TI  - Two Cases of Grave Complications of Purulent Ear Disease.

PMID- 29820752
TI  - Complete Hospital Co-Operation.

PMID- 29820753
TI  - Medical Opinion and Movement.

PMID- 29820754
TI  - To-Day and To-Morrow.

PMID- 29820755
TI  - A Clinical Lecture on the Disinfection and Care of the Hands.

PMID- 29820756
TI  - Special Analytical Health Commission on Tinned and Preserved Food: I. Preserved
      Meat Foods Prepared in England.

PMID- 29820757
TI  - The British Medical Association in Toronto.

PMID- 29820758
TI  - The Celebrations of the Quatro-Centenary of Aberdeen: Medical Interests and
      Medical Men: an Historical Retrospect.

PMID- 29820759
TI  - Sanitary Inspectors and Public Funds.

PMID- 29820760
TI  - Lumbar Puncture.

PMID- 29820761
TI  - Payments for Vaccination.

PMID- 29820762
TI  - Trips for Health and Pleasure.

PMID- 29820763
TI  - The Fitting and Furnishing of Wards and Operating Theatres.

PMID- 29820764
TI  - The Royal Hospital for Incurables.

PMID- 29820765
TI  - "The Hospital" Nursing Section.

PMID- 29820767
TI  - Annotations.

PMID- 29820766
TI  - Medical Opinion and Movement.

PMID- 29820769
TI  - The Clinical Laboratory: I. Rampant Pathology.

PMID- 29820768
TI  - The Treatment of Exophthalmic Goitre.

PMID- 29820770
TI  - The Old Mill.

PMID- 29820771
TI  - The Recovery Rate in Mental Hospitals.

PMID- 29820772
TI  - A Public Warning.

PMID- 29820773
TI  - Medical Aid for Soldiers in the Field: Its Principles and Organisation for a
      Field Force.

PMID- 29820774
TI  - The Chancellor's Offer to the Doctors.

PMID- 29820775
TI  - Sun-Planning for Hospitals.

PMID- 29820776
TI  - Research and Remedies.

PMID- 29820777
TI  - Guy's and the Southwark Guardians.

PMID- 29820778
TI  - The Institutional Worker.

PMID- 29820779
TI  - Unemployment Insurance.

PMID- 29820780
TI  - Hospital Needs.

PMID- 29820781
TI  - Government (Teaching) and Municipal (Non-Teaching) German Hospitals : IV. State
      versus Voluntary Hospitals.

PMID- 29820782
TI  - Housekeeping Queries.

PMID- 29820783
TI  - The Public's Medical Guides.

PMID- 29820784
TI  - Hospital and Institutional News.

PMID- 29820785
TI  - A Deficiency in the Hospital Service.

PMID- 29820786
TI  - Notes and News.

PMID- 29820787
TI  - Royal National Hospital for Consumption, Ventnor.

PMID- 29820789
TI  - Royal Chest Hospital, City Road.

PMID- 29820788
TI  - The Midwives Bill.

PMID- 29820790
TI  - Progress in State Medicine.

PMID- 29820791
TI  - Bacteriological Diphtheria.

PMID- 29820792
TI  - St. Mary's Paddington.

PMID- 29820793
TI  - The Registration and Inspection of Children's Homes.

PMID- 29820794
TI  - Annotations.

PMID- 29820795
TI  - Royal Dental Hospital of London.

PMID- 29820796
TI  - The Spread of Infection from Small-Pox Hospitals.

PMID- 29820797
TI  - The Diagnosis of Hydrophobia by Rapid Examination.

PMID- 29820798
TI  - French Hospital.

PMID- 29820799
TI  - Victoria Park Hospital.

PMID- 29820800
TI  - Progress in Surgery.

PMID- 29820801
TI  - The Hospital. Nursing Section.

PMID- 29820803
TI  - The Regeneration of Divided Nerves.

PMID- 29820802
TI  - The Influence of Posture on Heart Murmurs.

PMID- 29820805
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29820804
TI  - Home Hospitals Association.

PMID- 29820806
TI  - Notes and News.

PMID- 29820807
TI  - The London Post-Graduate Course at the Paddington Infirmary.

PMID- 29820808
TI  - No Gentleman Keeps a Bulldog.

PMID- 29820809
TI  - How to Keep Well.

PMID- 29820810
TI  - The History and Capabilities of Herbal Simples: XXI. Clover-Comfrey.

PMID- 29820812
TI  - Annotations.

PMID- 29820811
TI  - What? When? And How?

PMID- 29820813
TI  - Male Nurses.-I.

PMID- 29820814
TI  - The Medical Education of Women.

PMID- 29820816
TI  - Working Women in Large Towns: XIII. Some Sources of Distress.

PMID- 29820815
TI  - Low Birthrates and Population.

PMID- 29820818
TI  - The Story of the Insane from Year to Year.

PMID- 29820817
TI  - The Drink Question.

PMID- 29820819
TI  - The Attitude of Insurance Committees Towards Medical Benefit.

PMID- 29820820
TI  - A New Career for Women.

PMID- 29820822
TI  - The Patients and the Hospitals.

PMID- 29820821
TI  - Tuberculin Dispensaries.

PMID- 29820823
TI  - Self-Help in Institutional Economy: VI. The Information Bureau.

PMID- 29820824
TI  - A Legacy to the Metropolitan Asylums Board.

PMID- 29820825
TI  - The Institutional Worker.

PMID- 29820827
TI  - Recent Researches on Poliomyelitis.

PMID- 29820826
TI  - Printing by and for the Blind.

PMID- 29820828
TI  - The Mortuary Unit: The Public Part of the Mortuary.-III.

PMID- 29820830
TI  - Metropolitan Consumption Hospitals and the Insurance Act.

PMID- 29820829
TI  - Legacy Duty-The Rights of the Voluntary Hospitals.

PMID- 29820831
TI  - Inspections for Scarlet Fever.

PMID- 29820832
TI  - The L.C.C. and an Efficient Ambulance Service.

PMID- 29820834
TI  - The League of Mercy Collections.

PMID- 29820833
TI  - Some Dangers of Spoon-Feeding.

PMID- 29820836
TI  - Medical Service under the Poor Law: Interview with Dr. Frederic Orton.

PMID- 29820835
TI  - Hospital Weakness and Hospital Strength: Some Committees Which Fail: Two Amazing
      Examples.

PMID- 29820837
TI  - The Institutional Worker.

PMID- 29820838
TI  - Faradic Electricity.

PMID- 29820839
TI  - Hospital and Institutional News.

PMID- 29820840
TI  - Assistant Medical Officers in Asylums: The Need for Higher Emoluments and Better
      Accommodation.

PMID- 29820841
TI  - Are Lady Almoners Discourteous?

PMID- 29820843
TI  - Pathology.

PMID- 29820842
TI  - A Legacy to the Metropolitan Asylums Board.

PMID- 29820845
TI  - Mrs. Fawcett and Socialism.

PMID- 29820844
TI  - Diphtheria at Public Schools.

PMID- 29820846
TI  - November.

PMID- 29820847
TI  - Weil's Disease.

PMID- 29820848
TI  - Hemiatrophia Facialis.

PMID- 29820849
TI  - The Story of the Insane from Year to Year.

PMID- 29820850
TI  - The Relation of Modern Pathology and Pathological Anatomy to Practical Medicine.

PMID- 29820851
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29820852
TI  - Annotations.

PMID- 29820853
TI  - Flat-Foot.

PMID- 29820854
TI  - Iodides and Salicylates.

PMID- 29820855
TI  - Everybody's Page.

PMID- 29820856
TI  - The Hertford British Hospital.

PMID- 29820857
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29820858
TI  - Medical Schools in the United States.

PMID- 29820859
TI  - Tattlers.

PMID- 29820861
TI  - Notes and News.

PMID- 29820860
TI  - Menthol in Diphtheria.

PMID- 29820863
TI  - London as a Surgical Teaching Centre.

PMID- 29820862
TI  - The Study of Tropical Medicine.

PMID- 29820864
TI  - Post-Graduate Opportunities in Special Hospitals.

PMID- 29820865
TI  - Handbooks for Medical Students.

PMID- 29820867
TI  - Notes on Medical Schools and Colleges.

PMID- 29820866
TI  - Schools for Recent Graduates.

PMID- 29820869
TI  - Occupation for the Recent Graduate.

PMID- 29820868
TI  - "The Hospital" Nursing Section.

PMID- 29820870
TI  - Literary Workers.

PMID- 29820871
TI  - Qualification and Registration.

PMID- 29820873
TI  - Opportunities for Recent Graduates.

PMID- 29820872
TI  - London as a Medical Centre.

PMID- 29820874
TI  - The Two Oldest English Medical Books.

PMID- 29820875
TI  - Notes and News.

PMID- 29820876
TI  - Some Nerve Diseases.

PMID- 29820877
TI  - The Hospitals of Bristol.

PMID- 29820878
TI  - Annotations.

PMID- 29820879
TI  - Working Women in Large Towns: XV. Social, Moral, and Physical Aspects of the
      Subject.

PMID- 29820880
TI  - The Story of the Insane from Year to Year.

PMID- 29820881
TI  - Pathology.

PMID- 29820882
TI  - A Case of Supposed Indigenous Leprosy.

PMID- 29820883
TI  - What Not to Expect from Koch.

PMID- 29820884
TI  - Can Science Resolve the Doubt?

PMID- 29820885
TI  - Fifteen per Cent.

PMID- 29820886
TI  - Eyes and Noses.

PMID- 29820887
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29820889
TI  - Everybody's Page.

PMID- 29820888
TI  - Medical Schools: Bristol.

PMID- 29820890
TI  - "The Hospital" Nursing Section.

PMID- 29820891
TI  - Special Analytical and Health Commission on Tinned and Preserved Food: VII.
      Hogs', Boars', and Calves' Heads.

PMID- 29820892
TI  - Diseases of Abdomen.

PMID- 29820893
TI  - British Methods and Men of Science.

PMID- 29820894
TI  - The Natural History Museum.

PMID- 29820895
TI  - Structural and Practical Departments.

PMID- 29820896
TI  - British and American Hospitals: From an Australian Standpoint.

PMID- 29820897
TI  - New Appliances and Things Medical.

PMID- 29820898
TI  - Longevity.

PMID- 29820900
TI  - The Plane Tree of Hippocrates.

PMID- 29820899
TI  - Annotations.

PMID- 29820901
TI  - Abdominal Epilepsy.

PMID- 29820902
TI  - Chronic Suppuration in the Nasal Accessory Sinuses and Its Treatment.

PMID- 29820904
TI  - Fire Prevention: Appliances, Separating Partitions, and Staircases.

PMID- 29820903
TI  - Studies in Poor-Law Expenditure.

PMID- 29820906
TI  - The Medical Aspects of the Divorce Question.

PMID- 29820905
TI  - Hospital and Institutional News.

PMID- 29820907
TI  - The Crime of Administrative Blindness.

PMID- 29820908
TI  - Government (Teaching) and Municipal (Non-Teaching) German Hospitals: VII. Medical
      Treatment and Allowances for Kasse Patients.

PMID- 29820909
TI  - What the National Insurance Commissioners Cannot Do.

PMID- 29820910
TI  - The Weir Cottage Hospital, Balham, S.W.

PMID- 29820911
TI  - The Treatment of Acute Coryza.

PMID- 29820912
TI  - Athletics and Motherhood: An American View.

PMID- 29820913
TI  - The Institutional Worker.

PMID- 29820914
TI  - The Voluntary Hospitals' Opportunity.

PMID- 29820915
TI  - Workmen's Subscriptions and Representation.

PMID- 29820916
TI  - The Practical Training of the Territorial Voluntary Aid Detachments.

PMID- 29820917
TI  - Why Are the Voluntary Hospital Managers Inactive?

PMID- 29820918
TI  - The Removal of Westminster Hospital.

PMID- 29820919
TI  - Research and Remedies.

PMID- 29820920
TI  - The Truth about Child Protection.

PMID- 29820921
TI  - Radiography: A Plea for the Adoption of a Standard System of Units.

PMID- 29820923
TI  - Treatment of Flat-Foot.

PMID- 29820922
TI  - Scarlatina without Fever.

PMID- 29820924
TI  - Hypertrophy of the Prostate Gland.

PMID- 29820925
TI  - Everybody's Page.

PMID- 29820926
TI  - Poisons as Required.

PMID- 29820927
TI  - Ganglions.

PMID- 29820928
TI  - Infants' Food.

PMID- 29820929
TI  - Doctors and the Peerage.

PMID- 29820930
TI  - Treatment of Club-Foot.

PMID- 29820931
TI  - Mothers' Milk.

PMID- 29820933
TI  - Growth of Femur after Resection of Knee-Joint.

PMID- 29820932
TI  - Spina Ventosa.

PMID- 29820935
TI  - Spina Bifida.

PMID- 29820934
TI  - New Loves and Old.

PMID- 29820937
TI  - Hysterical Aphonia.

PMID- 29820936
TI  - Intratracheal Injections.

PMID- 29820938
TI  - Loeffler on Diphtheria.

PMID- 29820939
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29820940
TI  - The Microscope in Medicine: I. Introductory.

PMID- 29820942
TI  - The Infirmary Medical Superintendents' Society.

PMID- 29820941
TI  - The History and Capabilities of Herbal Simples: XXVI. Currants.

PMID- 29820943
TI  - Annotations.

PMID- 29820944
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29820945
TI  - Notes and News.

PMID- 29820946
TI  - Hospital and Institutional News.

PMID- 29820948
TI  - The Institutional Worker.

PMID- 29820947
TI  - Out-Patients and an Extension of the Almoner System.

PMID- 29820949
TI  - Research and Remedies.

PMID- 29820950
TI  - The Management of Young Infants.

PMID- 29820951
TI  - The Sphere of Institutional Treatment: II. The Collier in His Brick Box.

PMID- 29820952
TI  - How Government Grinds the Poor.

PMID- 29820953
TI  - The Use of the Bath in Medicine.

PMID- 29820954
TI  - The Prevention of Fire.

PMID- 29820955
TI  - The Treatment of Meningitis of Otitic Origin.

PMID- 29820956
TI  - The Hospital System in South Africa: Conditions of Work in the Cape Province.

PMID- 29820957
TI  - The Legal Duties of Hospital Governors.

PMID- 29820958
TI  - Service in Hospital Wards.

PMID- 29820959
TI  - The Campaign of the London Medical Committee.

PMID- 29820960
TI  - The Original Panelites: An Indignant Protest.

PMID- 29820961
TI  - Wake Up, Chancellor! Business First.

PMID- 29820962
TI  - The Hospital Treatment of Persons Who Have Attempted to Commit Suicide.

PMID- 29820963
TI  - The Voluntary Hospitals and Legacy Duty: Memorial to the Chancellor of the
      Exchequer.

PMID- 29820964
TI  - Away with Legacy Duty for Voluntary Hospitals: The Attitude of the Treasury.

PMID- 29820965
TI  - Hospital Laundries, Metropolitan and Provincial.

PMID- 29820966
TI  - Nelson Hospital.

PMID- 29820967
TI  - Hospital Needs.

PMID- 29820968
TI  - Research and Remedies.

PMID- 29820969
TI  - Laundry Accessories.

PMID- 29820970
TI  - The German System: V. The Financial Aspect of the German Hospitals.

PMID- 29820971
TI  - The Middlesex Hospital Laundry, Hendon.

PMID- 29820973
TI  - A Provincial Laundry Experience.

PMID- 29820972
TI  - Wake Up, Sleepers! The Time Has Come.

PMID- 29820975
TI  - The Use of Shunt Rheostats for Hydro-Electric Baths.

PMID- 29820974
TI  - Service by Retirement.

PMID- 29820976
TI  - A Question of Economy for Hospital Boards.

PMID- 29820978
TI  - The Institutional Worker.

PMID- 29820977
TI  - Reports on the Hospitals of the United Kingdom: LXVIII. Royal Victoria Infirmary,
      Newcastle-on-Tyne.

PMID- 29820980
TI  - The London Hospital Laundry, Whitechapel, E.

PMID- 29820979
TI  - Hospital and Institutional News.

PMID- 29820981
TI  - The "Times" on the Medical Profession.

PMID- 29820982
TI  - Hospital Benefit for Insured Persons by Pro Rata Payments and Not as Charity.

PMID- 29820983
TI  - A Loss to the Seamen's Hospital.

PMID- 29820984
TI  - The Heating and Ventilation of Hospital Wards.

PMID- 29820985
TI  - Insurance Committees.

PMID- 29820986
TI  - The Ipswich and East Suffolk Hospital.

PMID- 29820987
TI  - Research and Remedies.

PMID- 29820988
TI  - What Is British National Insurance to Be?: Less Than Nothing for Men and Women
      Workers Plus Degradation-Or What?

PMID- 29820989
TI  - The Institutional Worker.

PMID- 29820990
TI  - The Expenditure on Vaccine Therapeutics.

PMID- 29820991
TI  - Hospital and Institutional News.

PMID- 29820992
TI  - The British Hospitals Association.

PMID- 29820993
TI  - The British Hospitals Association and the Act.

PMID- 29820995
TI  - In-Patient Hospital Treatment for Insured Persons.

PMID- 29820994
TI  - Government (Teaching) and Municipal (Non-Teaching) German Hospitals : VIII. The
      Classification of In-patients and Conditions of Admission.

PMID- 29820996
TI  - Self-Help and Co-Operation in Institutional Economy: I. The Question of Initial
      Expenses.

PMID- 29820997
TI  - Special Analytical and Health Commission on Tinned and Preserved Food: VIII.
      Sauces and Pickles.

PMID- 29820998
TI  - Meeting of the British Medical Association, Toronto.

PMID- 29820999
TI  - Social and Poor Law Problems.

PMID- 29821000
TI  - Ancient Methods of Treatment: The Management of an English Leper House.

PMID- 29821001
TI  - New Appliances and Things Medical.

PMID- 29821002
TI  - Morocco and the Canary Islands as Health or Holiday Resorts.

PMID- 29821003
TI  - "The Hospital" Nursing Section.

PMID- 29821004
TI  - The Relation of Insanity to Civilisation-I.

PMID- 29821005
TI  - Infantile Mortality.

PMID- 29821006
TI  - Chronic Suppuration in the Nasal Accessory Sinuses and Its Treatment: II. The
      Treatment.

PMID- 29821007
TI  - Annotations.

PMID- 29821008
TI  - New Out-Patients' Department at the Middlesbrough Infirmary.

PMID- 29821009
TI  - The Story of the Insane from Year to Year.

PMID- 29821010
TI  - The Townshend Case.

PMID- 29821011
TI  - Medical Opinion and Movement.

PMID- 29821012
TI  - A Recent Epidemic of Measles at Rotuma.

PMID- 29821013
TI  - The Symptoms and Treatment of Cervical Rib.

PMID- 29821014
TI  - Hospital Reports and National Insurance: Newcastle, Sheffield, and West Ham.

PMID- 29821016
TI  - The Poor-Law Infirmary: I. The Present Position of the Infirmary Doctor.

PMID- 29821015
TI  - Some Dangers of Spoon-Feeding.

PMID- 29821018
TI  - The Curious History of L'Hotel-Dieu De Paris : I. Its Foundation and Early Days.

PMID- 29821017
TI  - The Metropolitan Hospital Sunday Fund Meeting.

PMID- 29821019
TI  - The Status of Assistant Medical Officers in Mental Hospitals.

PMID- 29821020
TI  - Staff Elections at King Edward VII.'s Hospital, Cardiff.

PMID- 29821021
TI  - The Prolongation of Useless Lives.

PMID- 29821022
TI  - The Use of X-Rays in the Diagnosis of Pulmonary Tuberculosis.

PMID- 29821023
TI  - Benefits for Nurses.

PMID- 29821024
TI  - The Institutional Worker.

PMID- 29821025
TI  - The King and the Chichester Infirmary.

PMID- 29821027
TI  - Electrical Plant for Cottage Hospitals.

PMID- 29821026
TI  - The Insurance Act and Poor-Law Infirmaries.

PMID- 29821029
TI  - A Comic History of British Nursing.

PMID- 29821028
TI  - Irregular Action of the Heart: The New Views, Terminology, and Instruments.

PMID- 29821030
TI  - At What Age Should a Baby Be Vaccinated?

PMID- 29821032
TI  - Hospital and Institutional News.

PMID- 29821031
TI  - Wanted, a Hospital Architect.

PMID- 29821033
TI  - Hospital Administration.

PMID- 29821034
TI  - Periscope of Dermatology.

PMID- 29821035
TI  - A Real Medical Strike.

PMID- 29821036
TI  - Hospital Construction.

PMID- 29821037
TI  - Notes.

PMID- 29821038
TI  - The Diagnosis of Gonococcus Infection.

PMID- 29821039
TI  - Progress in Medicine.

PMID- 29821040
TI  - Secret Commissions.

PMID- 29821041
TI  - A Sanitary Record of House Conditions.

PMID- 29821042
TI  - Notes and News.

PMID- 29821043
TI  - "The Hospital" Nursing Mirror.

PMID- 29821044
TI  - Annotations.

PMID- 29821047
TI  - Institutional Questions.

PMID- 29821046
TI  - Temporary Hospitals.

PMID- 29821048
TI  - Australian Inebriates Bill.

PMID- 29821049
TI  - The Likeness between Alcoholism and General Paralysis of the Insane.

PMID- 29821050
TI  - Precautions against Plague.

PMID- 29821051
TI  - New Appliances and Things Medical.

PMID- 29821052
TI  - Progress in Surgery.

PMID- 29821053
TI  - Modern Sociology.

PMID- 29821054
TI  - By the Way.

PMID- 29821055
TI  - Radiography.

PMID- 29821057
TI  - The Mortuary Unit: Institutional Interests-II.

PMID- 29821056
TI  - Cinema Theatres and Infectious Diseases.

PMID- 29821059
TI  - Hospital and Institutional News.

PMID- 29821058
TI  - Coal, Gas, and Electricity for Cooking.

PMID- 29821060
TI  - L'Hopital De La Charite De Paris.

PMID- 29821061
TI  - Is the Race Decaying?

PMID- 29821062
TI  - The Ethics of Local Anaesthesia.

PMID- 29821063
TI  - The Voluntary Hospitals Point the Way.

PMID- 29821064
TI  - A Retrospect of Christmas at Bristol.

PMID- 29821065
TI  - Panel Servitude: A Prophecy.

PMID- 29821066
TI  - The Institutional Worker.

PMID- 29821067
TI  - The Order of Mercy.

PMID- 29821068
TI  - Is Teething an Illness?

PMID- 29821069
TI  - Attitude of Marlborough, Pewsey, and Swindon Doctors.

PMID- 29821070
TI  - A New Departure at St. George's Infirmary.

PMID- 29821071
TI  - "Tree-Day" at Manchester Children's Hospital.

PMID- 29821072
TI  - The Salt of Their Profession.

PMID- 29821073
TI  - The Commencement of Benefits.

PMID- 29821074
TI  - "The Hospital" Nursing Section.

PMID- 29821075
TI  - New Appliances and Things Medical.

PMID- 29821077
TI  - Amaurotic Family History.

PMID- 29821076
TI  - Annotations.

PMID- 29821078
TI  - Notes and News.

PMID- 29821079
TI  - Professor Sims Woodhead at the Hospital Saturday Fund.

PMID- 29821080
TI  - The Fifteenth International Congress of Medicine.

PMID- 29821081
TI  - Endemic Goitre.

PMID- 29821082
TI  - Obstacles to Hygienic Achievement.

PMID- 29821083
TI  - X-Rays and Blood.

PMID- 29821084
TI  - Discussion on Syphilis.

PMID- 29821085
TI  - Isolation Hospital for the Ampthill District of Bedfordshire.

PMID- 29821086
TI  - Hospital Saturday Fund.

PMID- 29821087
TI  - The Role of Alcohol in the Treatment of Certain Diseases.

PMID- 29821088
TI  - Rheumatism.

PMID- 29821089
TI  - The Shortcomings of Plenum Ventilation.

PMID- 29821090
TI  - Hospital Meetings.

PMID- 29821091
TI  - Euthanasia.

PMID- 29821093
TI  - The Microscope in Medicine: V. Staining Sections.

PMID- 29821092
TI  - Everybody's Column.

PMID- 29821094
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821095
TI  - Treatment of Malignant Diseases.

PMID- 29821096
TI  - Veratrum Viride.

PMID- 29821097
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821099
TI  - The Lords' Committee.

PMID- 29821098
TI  - A Word for Poor Women.

PMID- 29821100
TI  - Sciatica.

PMID- 29821101
TI  - A Counsel of Despair.

PMID- 29821102
TI  - Recreation in Relation to the Health of the People: III. Working Up.

PMID- 29821103
TI  - Legal Restrictions on Gifts to Charity.

PMID- 29821104
TI  - Annotations.

PMID- 29821105
TI  - Notes and News.

PMID- 29821106
TI  - Impressions of a Novice.

PMID- 29821107
TI  - Hospital and Institutional News.

PMID- 29821108
TI  - The Institutional Worker.

PMID- 29821109
TI  - Colliers and Cardiff Hospitals.

PMID- 29821111
TI  - The Metropolitan Hospital Sunday Fund Crisis.

PMID- 29821110
TI  - A Retrospect.

PMID- 29821112
TI  - Death of a London Hospital Foundress.

PMID- 29821113
TI  - Annual Meeting and Distribution of Grants.

PMID- 29821114
TI  - An Animated Meeting of Constituents.

PMID- 29821115
TI  - The Views of the Working Classes: Their Demand for Hospital Benefit Not as a
      Matter of Charity, but of Right.

PMID- 29821116
TI  - The Doctors' Decision.

PMID- 29821117
TI  - Aprosexia in Children.

PMID- 29821118
TI  - Notes and News.

PMID- 29821119
TI  - Antiseptic Surgery.

PMID- 29821120
TI  - The Microscope in Medicine: VIII.-The Examination of Sputum.

PMID- 29821122
TI  - On the Right Track.

PMID- 29821121
TI  - Some Risks of Middle Age.

PMID- 29821124
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821123
TI  - Ignatia Amara.

PMID- 29821125
TI  - Fissures of the Tongue.

PMID- 29821126
TI  - Registration of Nurses.

PMID- 29821127
TI  - Annotations.

PMID- 29821128
TI  - The Lords' Committee.

PMID- 29821129
TI  - On Diseases of the Pancreas.

PMID- 29821130
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821132
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821131
TI  - Body and Mind at Cambridge.

PMID- 29821133
TI  - Granular Ophthalmia.

PMID- 29821134
TI  - The Other Side of the Shield.

PMID- 29821136
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821135
TI  - The Parting Message.

PMID- 29821138
TI  - Give and Take.

PMID- 29821137
TI  - Notes and News.

PMID- 29821140
TI  - Annotations.

PMID- 29821139
TI  - The Doctor's Difflculties in Town and Country.

PMID- 29821141
TI  - Antiseptic Surgery.

PMID- 29821142
TI  - Gastric Ulcer.

PMID- 29821143
TI  - Escholtzia Californica.

PMID- 29821144
TI  - Everybody's Page.

PMID- 29821145
TI  - The Microscope in Medicine: VII. Methods of Staining Sections of the Nervous
      System.

PMID- 29821146
TI  - The Lords' Committee.

PMID- 29821148
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821147
TI  - A Critic Criticised.

PMID- 29821149
TI  - On the Treatment of Cough.

PMID- 29821150
TI  - Medical Book-Keeping.

PMID- 29821151
TI  - Cardiovascular Vertigo.

PMID- 29821152
TI  - Reflex Epilepsy from Dental Caries.

PMID- 29821153
TI  - Anomalous Ataxies.

PMID- 29821154
TI  - The Microscope in Medicine: IV. "Cutting Sections".

PMID- 29821155
TI  - Everybody's Page.

PMID- 29821156
TI  - A Dream: Perhaps a Delusion.

PMID- 29821158
TI  - Working Women in Large Towns: XIX. What the General Public May Do.

PMID- 29821157
TI  - Diabetic Coma.

PMID- 29821159
TI  - Notes and News.

PMID- 29821160
TI  - Annotations.

PMID- 29821161
TI  - Primary Acute Encephalitis.

PMID- 29821162
TI  - A New Cause of Tabes.

PMID- 29821163
TI  - Medical Women at the Johns Hopkins University.

PMID- 29821164
TI  - Euphorine.

PMID- 29821165
TI  - Diseases of Digestive Organs.

PMID- 29821166
TI  - Hospital Meetings.

PMID- 29821167
TI  - The Bolingbroke Hospital.

PMID- 29821168
TI  - Gallant's Corsets in the Treatment of Enteroptosis.

PMID- 29821170
TI  - South Staffordshire Hospital for Small-Pox.

PMID- 29821169
TI  - Annotations.

PMID- 29821172
TI  - Stigmata of Degeneration and the Pregnesis of Epilepsy.

PMID- 29821171
TI  - On the Causes and Treatment of Gangrene of the Leg.

PMID- 29821173
TI  - Current Hospital Topics.

PMID- 29821174
TI  - The Prolongation of Life.

PMID- 29821175
TI  - Social and Poor Law Problems.

PMID- 29821176
TI  - "The Hospital" Nursing Section.

PMID- 29821177
TI  - Notes and News.

PMID- 29821178
TI  - Motor Cars for Doctors: Cars Suitable for Practitioners.

PMID- 29821180
TI  - Diseases of the Blood.

PMID- 29821179
TI  - New Appliances and Things Medical.

PMID- 29821181
TI  - Discussion on Syphilis.

PMID- 29821182
TI  - Treatment of Detached Retina by Iodine Injections into the Bulb.

PMID- 29821183
TI  - The Life Problem at Forty.

PMID- 29821184
TI  - The Story of the Insane from Year to Year.

PMID- 29821186
TI  - Everybody's Page.

PMID- 29821185
TI  - The History and Capabilities of Herbal Simples: XXII.-Coltsfoot.

PMID- 29821188
TI  - Poisoning by Colchicin.

PMID- 29821187
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821189
TI  - Notes and News.

PMID- 29821190
TI  - Physical Education in America.

PMID- 29821191
TI  - Working Women in Large Towns: XIV. Some Sources of Distress.

PMID- 29821192
TI  - Pathology.

PMID- 29821193
TI  - Entries, Winter Session, 1890-91.

PMID- 29821194
TI  - What Says the Student?

PMID- 29821195
TI  - Diseases of the Bladder and Prostate.

PMID- 29821196
TI  - Hospital Choirs.

PMID- 29821197
TI  - The Greatest Medical Library of the World.

PMID- 29821198
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821199
TI  - Annotations.

PMID- 29821200
TI  - Metropolitan Hospital for the Insane.

PMID- 29821202
TI  - Annotations.

PMID- 29821201
TI  - Torticollis.

PMID- 29821203
TI  - Notes and News.

PMID- 29821204
TI  - The College of Physicians in a New Character.

PMID- 29821205
TI  - A Feat to Be Considered.

PMID- 29821207
TI  - The Microscope in Medicine: X.-The Examination of Urinary Deposits.

PMID- 29821206
TI  - An Unhappy Juxtaposition.

PMID- 29821209
TI  - Everybody's Page.

PMID- 29821208
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821210
TI  - Rhus Toxicodendron.

PMID- 29821211
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821212
TI  - The Lords' Committee.

PMID- 29821213
TI  - On the Therapeutical Action of Koch's Remedy.

PMID- 29821214
TI  - Employees and the National Insurance Act.

PMID- 29821215
TI  - Conference at Birmingham.

PMID- 29821216
TI  - Reports on the Hospitals of the United Kingdom.

PMID- 29821217
TI  - The Draft Poor-Law Order: A Workhouse Medical Officer's View.

PMID- 29821218
TI  - The Institutional Worker.

PMID- 29821219
TI  - Formamint in the Treatment of Oral Conditions.

PMID- 29821220
TI  - Collector or Secretary?

PMID- 29821221
TI  - Hospital and Institutional News.

PMID- 29821222
TI  - National Insurance in Germany and Great Britain.

PMID- 29821223
TI  - Research and Remedies.

PMID- 29821225
TI  - Heart Cases in School Life.

PMID- 29821224
TI  - The Sessional Medical Addresses.

PMID- 29821226
TI  - Hospital Almoners and Saturday Fund Subscribers.

PMID- 29821227
TI  - Foreign Books for the Institutional Library.

PMID- 29821228
TI  - The Royal Victoria Infirmary, Newcastle: A Little Known Literary Association.

PMID- 29821229
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821230
TI  - The Pineal Body.

PMID- 29821232
TI  - The Metropolitan Hospital Sunday Fund.

PMID- 29821231
TI  - The Hospital Saturday Fund.

PMID- 29821233
TI  - On Starting a Medical Library.

PMID- 29821234
TI  - The Institutional Library.

PMID- 29821235
TI  - Some Architectural and Sanitation Pamphlets.

PMID- 29821236
TI  - The Progress of Lung Surgery.

PMID- 29821237
TI  - The Hospital Saturday Fund and Lady Almoners.

PMID- 29821238
TI  - Benefits in Respect of Persons in Hospital.

PMID- 29821239
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29821240
TI  - Hospital and Institutional News.

PMID- 29821241
TI  - The Institutional Worker.

PMID- 29821243
TI  - Are Saturday Fund Subscribers Entitled to Free Medical Relief?

PMID- 29821242
TI  - Planning for Sunlight: The Orientation of Buildings.

PMID- 29821244
TI  - Surgery.

PMID- 29821245
TI  - Annotations.

PMID- 29821247
TI  - The Story of the Insane from Year to Year.

PMID- 29821246
TI  - Education General and Medical.

PMID- 29821248
TI  - Special Analytical and Health Commission on Tinned and Preserved Food: IX.
      Condiments-Preserved Fish-Preserved Rabbit.

PMID- 29821249
TI  - Isolation Hospital for Burslem.

PMID- 29821250
TI  - The "Respectability" of the Out-Patient.

PMID- 29821251
TI  - Some Notes on Common Skin Diseases.

PMID- 29821252
TI  - The Fitting and Furnishing of Wards and Operating Theatres.

PMID- 29821253
TI  - Medical Opinion and Movement.

PMID- 29821254
TI  - The Aertex Cellular Clothing Factory, Swindon.

PMID- 29821255
TI  - New Appliances and Things Medical.

PMID- 29821256
TI  - Some Observations on Diseases of the Digestive Organs: Dyspepsia and the Nervous
      System.

PMID- 29821257
TI  - The Relation of Insanity to Civilisation.-II.

PMID- 29821259
TI  - Pathology.

PMID- 29821258
TI  - "The Hospital" Nursing Section.

PMID- 29821260
TI  - Koch's Notes of Warning.

PMID- 29821261
TI  - Notes and News.

PMID- 29821262
TI  - Captain Cook.

PMID- 29821263
TI  - Twenty-One or Twenty-Three?

PMID- 29821264
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821265
TI  - Diphtheria at Marlborough College.

PMID- 29821267
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821266
TI  - The National Pension Fund and Workers.-II.

PMID- 29821268
TI  - A New Antiseptic Treatment of Wounds.

PMID- 29821269
TI  - Nurses' Food, Work, and Hours of Recreation.

PMID- 29821270
TI  - Pulmonary Phthisis.

PMID- 29821272
TI  - Annotations.

PMID- 29821271
TI  - Rheumatism.

PMID- 29821273
TI  - British Red Cross Society: Message from the Prince of Wales.

PMID- 29821274
TI  - King's College Hospital.

PMID- 29821275
TI  - Hospital Meetings.

PMID- 29821276
TI  - Surgical Homes.

PMID- 29821277
TI  - Nervous Diseases.

PMID- 29821278
TI  - The Present Position of Radiation in Treatment.

PMID- 29821280
TI  - The Visit of Metchnikoff.

PMID- 29821279
TI  - The American Ambassador on Hospitals.

PMID- 29821281
TI  - Notes and News.

PMID- 29821282
TI  - Current Hospital Topics.

PMID- 29821283
TI  - Annotations.

PMID- 29821284
TI  - Medical Opinion and Movement.

PMID- 29821285
TI  - "The Hospital" Nursing Section.

PMID- 29821286
TI  - Broncho Pneumonia and Abscess of the Lung.

PMID- 29821287
TI  - Help the Defectives.

PMID- 29821288
TI  - On Typhoid Fever.

PMID- 29821289
TI  - Alcohol in Relation to Therapeutics.

PMID- 29821290
TI  - New Appliances and Things Medical.

PMID- 29821291
TI  - Social and Poor-Law Problems.

PMID- 29821292
TI  - Criminals: How to Make and How to Mend Them.

PMID- 29821293
TI  - The Approach of Cholera.

PMID- 29821294
TI  - The New Loves Gain the Day.

PMID- 29821295
TI  - Suggestions to the Lords.

PMID- 29821296
TI  - Notes and News.

PMID- 29821297
TI  - Tubercular Diseases of the Bones and Joints.

PMID- 29821298
TI  - Winter Feedings.

PMID- 29821300
TI  - Everybody's Page.

PMID- 29821299
TI  - The History and Capabilities of Herbal Simples: XXVII. The Common Daisy.

PMID- 29821302
TI  - Erysipelas: New Methods of Treatment.

PMID- 29821301
TI  - Annotations.

PMID- 29821303
TI  - Ouabaine.

PMID- 29821304
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821305
TI  - The Story of the Insane from Year to Year.

PMID- 29821306
TI  - Cold Treatment of Pneumonia.

PMID- 29821308
TI  - Notes and News.

PMID- 29821307
TI  - German Universities and English Students.

PMID- 29821309
TI  - The Climatology of England.

PMID- 29821310
TI  - Women and Nerves.

PMID- 29821311
TI  - A Department of Public Safety.

PMID- 29821312
TI  - Some Curious Patents.

PMID- 29821313
TI  - Heart Disease.

PMID- 29821314
TI  - Everybody's Page.

PMID- 29821315
TI  - The Story of the Insane from Year to Year.

PMID- 29821316
TI  - Life Preservation from a Business Point of View.

PMID- 29821318
TI  - The Perfection of Human Happiness.

PMID- 29821317
TI  - Pathology.

PMID- 29821319
TI  - Ought Women to Be on Hospital Committees?

PMID- 29821320
TI  - Annotations.

PMID- 29821321
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821322
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821323
TI  - Male Nurses.-II.

PMID- 29821324
TI  - On the Non-Contagiousness of Cancer.

PMID- 29821325
TI  - On Cancer.

PMID- 29821326
TI  - Crude Science.

PMID- 29821327
TI  - Northerner and Southerner.

PMID- 29821328
TI  - The Workhouse Infirmary Nursing Association: Interview with Miss J. Wilson.

PMID- 29821329
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821330
TI  - Work and Food.

PMID- 29821332
TI  - Has a New Day Dawned?

PMID- 29821331
TI  - The National Pension Fund and Workers.-III.

PMID- 29821333
TI  - The Lords and the Hospitals.

PMID- 29821334
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821335
TI  - Everybody's Page.

PMID- 29821336
TI  - December.

PMID- 29821338
TI  - Notes and News.

PMID- 29821337
TI  - Working Women in Large Towns: XVII. Aids for Working Women.

PMID- 29821339
TI  - Pathology.

PMID- 29821340
TI  - Annotations.

PMID- 29821341
TI  - The Saturday Fund and the Hospitals.

PMID- 29821343
TI  - Hospital and Institutional News.

PMID- 29821342
TI  - The Metropolitan Hospital Sunday Fund Meeting.

PMID- 29821345
TI  - Fibrositis.

PMID- 29821344
TI  - The Treatment of Tuberculosis.

PMID- 29821347
TI  - The Editor's Letter-Box.

PMID- 29821346
TI  - The Use of Seleniol Injections for Sarcoma.

PMID- 29821349
TI  - The Problem of the Mentally Defective: Discussion at Central Poor-Law Conference.

PMID- 29821348
TI  - Views of Some British Architects.

PMID- 29821350
TI  - The London Hospital Saturday Fund and the National Insurance Act: Some Views and
      Fears of the Saturday Fund Executive.

PMID- 29821352
TI  - Post-Mortem Examinations without Permission.

PMID- 29821351
TI  - Medical Benefits for Nursing Staffs.

PMID- 29821353
TI  - The Voluntary Hospitals and Legacy Duty: Away with Legacy Duty on Hospital
      Legacies!

PMID- 29821354
TI  - The Institutional Worker.

PMID- 29821355
TI  - An Efficient Ambulance Service for London: Not Politics but Business.

PMID- 29821356
TI  - Mr. Lewcock's Letter and the Hospital Saturday Executive.

PMID- 29821358
TI  - King Edward VII's Hospital, Cardiff.

PMID- 29821357
TI  - Poor-Law Infirmaries and Voluntary Hospitals.

PMID- 29821359
TI  - Institutional Needs.

PMID- 29821360
TI  - Concerning Tuberculin.

PMID- 29821362
TI  - Human Effort in Polar Climates.

PMID- 29821361
TI  - The Clinical Laboratory: III. The Clinical Laboratory in Diabetes.

PMID- 29821363
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821364
TI  - The Mark of the Beast: Some Notes on Criminal Anthropology.

PMID- 29821365
TI  - Everybody's Page.

PMID- 29821366
TI  - Some Medical Aspects of Tropical Colonisation.

PMID- 29821367
TI  - Poisoning by Antipyrin.

PMID- 29821369
TI  - Chronic Disease of the Knee Joint in Children.

PMID- 29821368
TI  - The Microscope in Medicine: VI.-Mounting Specimens.

PMID- 29821370
TI  - Annotations.

PMID- 29821371
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821373
TI  - Notes and News.

PMID- 29821372
TI  - Some Functional Disorders of the Heart.

PMID- 29821374
TI  - Where Do We Stand?

PMID- 29821375
TI  - The Hospital Saturday Fund Disagreement.

PMID- 29821376
TI  - The Lords' Committee.

PMID- 29821377
TI  - Are Doctors so Very Bad?

PMID- 29821378
TI  - Science in Straits.

PMID- 29821379
TI  - Strychnine as an Antidote.

PMID- 29821380
TI  - Chorea.

PMID- 29821381
TI  - Infants' Food.

PMID- 29821382
TI  - Association of Gangrene and Tetanus.

PMID- 29821383
TI  - Surgical Treatment of Hydrocephalus.

PMID- 29821385
TI  - The Etiology of Cancer.

PMID- 29821384
TI  - The Microscope in Medicine: III. The Microtome and Hardening Specimens.

PMID- 29821386
TI  - Notes and News.

PMID- 29821387
TI  - A Mild Rebuke.

PMID- 29821389
TI  - Annotations.

PMID- 29821388
TI  - Rickets: Treatment by Phosphorus.

PMID- 29821390
TI  - The Metropolitan Hospital Saturday Fund.

PMID- 29821391
TI  - The London Poor.

PMID- 29821392
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821393
TI  - Recreation in Relation to the Health of the People: II. Beginning at the Bottom.

PMID- 29821394
TI  - Current Hospital Topics.

PMID- 29821395
TI  - "The Hospital" Nursing Section.

PMID- 29821396
TI  - New Appliances and Things Medical.

PMID- 29821397
TI  - The Society for the Study of Diseases in Children.

PMID- 29821398
TI  - Broncho-Pneumonia.

PMID- 29821399
TI  - Current Professional Opinion.

PMID- 29821400
TI  - New Remedies and Results.

PMID- 29821401
TI  - The Treatment of Shock and Collapse Following Surgical Operations.

PMID- 29821402
TI  - Motor-Cars for Doctors: General Description.

PMID- 29821403
TI  - Hospital Meetings.

PMID- 29821404
TI  - Annotations.

PMID- 29821405
TI  - Mr. P. J. Michelli: At Home at the Royal Victoria and Albert Docks Hospital.

PMID- 29821406
TI  - Chemists and Companies.

PMID- 29821407
TI  - Malignant Endocarditis Treated by Antistreptococcic Serum.

PMID- 29821408
TI  - Hospital Dinners and Annual Meetings.

PMID- 29821409
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821410
TI  - Typhlitis, Perityphlitis, and Appendicitis.

PMID- 29821412
TI  - Intestinal Antisepsis in Dyspepsia.

PMID- 29821411
TI  - The London County Council and Hospital Assessment.

PMID- 29821413
TI  - Notes and News.

PMID- 29821414
TI  - The Lords' Committee.

PMID- 29821416
TI  - Medical Women in England.

PMID- 29821415
TI  - The History and Capabilities of Herbal Simples: XXVIII.-The Dandelion.

PMID- 29821418
TI  - The Gnat and the Camel.

PMID- 29821417
TI  - The Microscope in Medicine: IX.-Examination of the Sputum.

PMID- 29821420
TI  - Annotations.

PMID- 29821419
TI  - Membranous Ophthalmia.

PMID- 29821421
TI  - Midwives Registration-A General Practitioner's Protest.

PMID- 29821422
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821423
TI  - Annotations.

PMID- 29821424
TI  - Notes and News.

PMID- 29821425
TI  - Dithiosalicylate of Soda.

PMID- 29821426
TI  - The Midwives' Bill: A Select Committee.

PMID- 29821428
TI  - The Lords' Committee.

PMID- 29821427
TI  - Medical Women and the Royal Free Hospital.

PMID- 29821429
TI  - The Jubilee Institute for Nurses.

PMID- 29821431
TI  - The Registration of Midwives.

PMID- 29821430
TI  - Body and Mind at Cambridge.

PMID- 29821432
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821433
TI  - Erythro-Melalgia.

PMID- 29821435
TI  - The Pathological and Surgical Treatment of Suppurative Tonsilitis.

PMID- 29821434
TI  - Herpes.

PMID- 29821437
TI  - A New Interpreter of Faith.

PMID- 29821436
TI  - The History and Capabilities of Herbal Simples: XXIX.-Dill.

PMID- 29821438
TI  - Everybody's Page.

PMID- 29821439
TI  - Diseases of the Intracranial Vessels in Children.

PMID- 29821440
TI  - The Surgical Treatment of Encephalocele.

PMID- 29821441
TI  - Pennyroyal.

PMID- 29821442
TI  - Annotations.

PMID- 29821443
TI  - Everybody's Page.

PMID- 29821444
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29821445
TI  - Lupus and Tuberculosis.

PMID- 29821446
TI  - Treatment of Diphtheria.

PMID- 29821447
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821448
TI  - Strychnine Poisoning.

PMID- 29821449
TI  - Uniformity in Accounts.

PMID- 29821450
TI  - Pilocarpine in Skin Diseases.

PMID- 29821451
TI  - Notes and News.

PMID- 29821452
TI  - Bromethyl.

PMID- 29821453
TI  - Virchow and Koch.

PMID- 29821454
TI  - Spontaneous Expulsion of a Foreign Body from the Bronchi.

PMID- 29821455
TI  - Recreation in Relation to the Health of the People: I. Introductory.

PMID- 29821456
TI  - The Microscope in Medicine: II. The Use of the Microscope.

PMID- 29821457
TI  - Lanolin and Vaseline.

PMID- 29821458
TI  - The Uses of a Year-Book.

PMID- 29821459
TI  - King Edward's Hospital Fund for London: The Annual Meeting.

PMID- 29821460
TI  - Genito-Urinary Surgery.

PMID- 29821461
TI  - The Opportunity of Clinical Pathology.

PMID- 29821462
TI  - "The Hospital" Nursing Section.

PMID- 29821463
TI  - Notes and News.

PMID- 29821464
TI  - Diseases of the Nervous System.

PMID- 29821465
TI  - Hospital Saturday Fund.

PMID- 29821467
TI  - Hospital Meetings.

PMID- 29821466
TI  - Hernia in Children.

PMID- 29821468
TI  - Annotations.

PMID- 29821469
TI  - "The Hospital" Nursing Section.

PMID- 29821470
TI  - Remedies and Their Uses.

PMID- 29821472
TI  - Special Analytical and Health Commission on Tinned and Preserved Food: VI.
      "Special" Canned Meat Foods.

PMID- 29821471
TI  - The Treatment of Diphtheria.

PMID- 29821473
TI  - Smell in Health and Disease.

PMID- 29821474
TI  - A Clinical Lecture on Infantile Paralysis.

PMID- 29821475
TI  - Current Hospital Topics.

PMID- 29821476
TI  - Social and Poor Law Problems.

PMID- 29821477
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821478
TI  - Medical Opinion and Movement.

PMID- 29821479
TI  - British and American Hospitals: From an Australian Standpoint.

PMID- 29821481
TI  - Annotations.

PMID- 29821480
TI  - New Appliances and Things Medical.

PMID- 29821482
TI  - Psychic Effects of the San Francisco Earthquake.

PMID- 29821483
TI  - Boston Hospital, Boston.

PMID- 29821484
TI  - Annotations.

PMID- 29821485
TI  - Epilogue.

PMID- 29821486
TI  - Mr. Gladstone: Sir George Stokes.

PMID- 29821487
TI  - General Hospitals.

PMID- 29821488
TI  - Hypnotism.

PMID- 29821489
TI  - Pay Hospitals.

PMID- 29821491
TI  - A Few Other Charities.

PMID- 29821490
TI  - The C.O.S. as Collector for Charities.

PMID- 29821493
TI  - The Registration of Midwives.

PMID- 29821492
TI  - Nursing Institutions.

PMID- 29821494
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821495
TI  - Koch and the Consumption Cure.

PMID- 29821496
TI  - The Luxury of Giving.

PMID- 29821497
TI  - Who Are the Philanthropists?

PMID- 29821499
TI  - Asylum for Idiots.

PMID- 29821498
TI  - The National Pension Fund.

PMID- 29821500
TI  - Hospitals for Consumption.

PMID- 29821501
TI  - Miscellaneous Special Hospitals.

PMID- 29821502
TI  - Pasteur and Hydrophobia.

PMID- 29821503
TI  - Black Clouds over Hospitals.

PMID- 29821504
TI  - Nurses' Registration.

PMID- 29821505
TI  - The Dead.

PMID- 29821507
TI  - Lying-In Hospitals.

PMID- 29821506
TI  - Hospitals for Children.

PMID- 29821508
TI  - Nervous Diseases, Epilepsy, and Paralysis.

PMID- 29821509
TI  - Kosher and Trifa.

PMID- 29821510
TI  - Hepatic Cirrhosis.

PMID- 29821511
TI  - Everybody's Page.

PMID- 29821512
TI  - Removal of Deformity of Rickety Limbs.

PMID- 29821514
TI  - Noises in the Ears.

PMID- 29821513
TI  - Treatment of Cold Abscess by Iodoform.

PMID- 29821515
TI  - Urticaria.

PMID- 29821517
TI  - Spontaneous Restoration of the Membrana Tympani.

PMID- 29821516
TI  - The History and Capabilities of Herbal Simples: XXV.-Cress.

PMID- 29821518
TI  - A Sober Critic of Koch.

PMID- 29821519
TI  - Notes and News.

PMID- 29821520
TI  - A Wandering Liver.

PMID- 29821521
TI  - Annotations.

PMID- 29821522
TI  - Hypnotism.

PMID- 29821523
TI  - Cataract.

PMID- 29821524
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29821525
TI  - Hydatid Cysts of Liver.

PMID- 29821526
TI  - Has Pasteur Failed?

PMID- 29821527
TI  - The Season of Appeals.

PMID- 29821528
TI  - Gorlaston Cottage Hospital.

PMID- 29821529
TI  - Fibroid Lung.

PMID- 29821530
TI  - Institutional Notes and News.

PMID- 29821531
TI  - Annotations.

PMID- 29821532
TI  - Medical Opinion and Movement.

PMID- 29821533
TI  - The Hospital World.

PMID- 29821534
TI  - The Differential Diagnosis of Vertigo.

PMID- 29821536
TI  - The Anaesthetist's Ante-Room.

PMID- 29821535
TI  - Whitlow: II. Complications and Treatment.

PMID- 29821538
TI  - Judgment and Observation.

PMID- 29821537
TI  - Cervical Ribs.

PMID- 29821539
TI  - The Complications of Operations for Glands in Neck.

PMID- 29821540
TI  - Lunacy Reformation.

PMID- 29821541
TI  - The Week's Work.

PMID- 29821542
TI  - Reports on the Hospitals of the United Kingdom: Some Smaller Hospitals.

PMID- 29821544
TI  - News and Events of the Week.

PMID- 29821543
TI  - Hospitals and the Doctrine of "Cy-Pres".

PMID- 29821545
TI  - Institutional Notes and News.

PMID- 29821546
TI  - The Treatment of Sepsis.

PMID- 29821547
TI  - Doctor and Parson.

PMID- 29821548
TI  - Quack Medicines.

PMID- 29821550
TI  - The Week's Work.

PMID- 29821549
TI  - Medical Opinion and Movement.

PMID- 29821551
TI  - The Hospital World.

PMID- 29821553
TI  - The Military Training of the Officers of the R.A.M.C. (T.F.).

PMID- 29821552
TI  - Medical Men and Midwives.

PMID- 29821554
TI  - The Rating of Voluntary Hospitals.

PMID- 29821555
TI  - Whitlow: I. Varieties and Diagnosis.

PMID- 29821556
TI  - A Note on a Case of Traumatic Encephalocele.

PMID- 29821557
TI  - An International Committee for Graduate Study.

PMID- 29821558
TI  - A Lecture on Placenta Praevia.

PMID- 29821559
TI  - Fourth Annual Conference of the Canadian Hospital Association in Montreal.

PMID- 29821560
TI  - New Appliances and Things Medical.

PMID- 29821562
TI  - Hospital Contracts and Prices-II.

PMID- 29821561
TI  - Reports on the Hospitals of the United Kingdom: XXXIX. Worcester General
      Infirmary.

PMID- 29821564
TI  - Organising Graduate Instruction.

PMID- 29821563
TI  - News and Events of the Week.

PMID- 29821565
TI  - Annotations.

PMID- 29821566
TI  - Post-Graduate Study in the Rotunda Hospital.

PMID- 29821567
TI  - New Appliances & Things Medical.

PMID- 29821568
TI  - News and Events of the Week.

PMID- 29821569
TI  - The Week's Work.

PMID- 29821570
TI  - National Hospital for the Paralysed and Epileptic, Queen Square.

PMID- 29821571
TI  - Prognostic Difficulties in Atypical Pneumonia.

PMID- 29821572
TI  - The Hospital World.

PMID- 29821573
TI  - Medical Opinion and Movement.

PMID- 29821574
TI  - Popularising the Annual Report.

PMID- 29821575
TI  - The Present and Future of Graduate Medical Study.

PMID- 29821576
TI  - Institutional Notes and News.

PMID- 29821577
TI  - Hospital Contracts and Prices.

PMID- 29821579
TI  - The Future of Graduate Instruction in Medicine.

PMID- 29821578
TI  - Eye Injuries.

PMID- 29821581
TI  - Reports on the Hospitals of the United Kingdom: XXXVIII. The Manchester Royal
      Infirmary.

PMID- 29821580
TI  - Old Needlework.

PMID- 29821582
TI  - The Medical Inspection and Treatment of School Children.

PMID- 29821583
TI  - Annotations.

PMID- 29821584
TI  - The Hospital World.

PMID- 29821586
TI  - Weil's Disease.

PMID- 29821585
TI  - Tobacco Amblyopia.

PMID- 29821587
TI  - Annotations.

PMID- 29821588
TI  - Reports on the Hospitals of the United Kingdom: XL. David Lewis Northern
      Hospital, Liverpool.

PMID- 29821589
TI  - Institutional Notes and News.

PMID- 29821590
TI  - The Medical Student and His Work.

PMID- 29821591
TI  - Some Practical Notes.

PMID- 29821592
TI  - The English and German Physician through French Eyes.

PMID- 29821593
TI  - Medical Opinion and Movement.

PMID- 29821594
TI  - Hospital Contracts and Prices: III. The Purchase of Drugs.

PMID- 29821595
TI  - Calomel in Heart Cases.

PMID- 29821596
TI  - Therapeutic Discrimination.

PMID- 29821598
TI  - News and Events of the Week.

PMID- 29821597
TI  - Sporo-Thrichotic Arthritis of the Knee.

PMID- 29821600
TI  - The Foundling Hospital in Florence.

PMID- 29821599
TI  - The Week's Work.

PMID- 29821601
TI  - The Late Dr. T. D. Savill.

PMID- 29821603
TI  - Institutional Notes and News.

PMID- 29821602
TI  - Annotations.

PMID- 29821605
TI  - News and Events of the Week.

PMID- 29821604
TI  - The Week's Work.

PMID- 29821607
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821606
TI  - The Surgical Problem Presented by the Acutely Distended Abdomen.

PMID- 29821608
TI  - Albumosuria.

PMID- 29821609
TI  - Voluntary Aid Detachments.

PMID- 29821610
TI  - The Significance of the Epiphyses.

PMID- 29821611
TI  - The Blood-Pressure during Pregnancy and the Puerperium.

PMID- 29821612
TI  - Pregnancy and Diabetes.

PMID- 29821613
TI  - Pavor Nocturnus in Children.

PMID- 29821615
TI  - Medical Opinion and Movement.

PMID- 29821614
TI  - International Congress of Pharmacy.

PMID- 29821616
TI  - The Hospital World.

PMID- 29821617
TI  - So-Called Influenzal Attacks Which Are Really Indicative of Phthisis.

PMID- 29821619
TI  - The British Hospitals Association Conference.

PMID- 29821618
TI  - Acute Intestinal Obstruction-II.

PMID- 29821620
TI  - Some Common Causes of Pain in the Foot.-I.

PMID- 29821621
TI  - A Rapid and Delicate Method of Detecting Bile Pigment in Urine.

PMID- 29821623
TI  - The Payment of Hospital Staffs.

PMID- 29821622
TI  - Medical Opinion and Movement.

PMID- 29821624
TI  - Sanatoria for Kent.

PMID- 29821625
TI  - Parliament and Publications.

PMID- 29821626
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821627
TI  - Acute Intestinal Obstruction.

PMID- 29821628
TI  - The Payment of Hospital Staffs.

PMID- 29821630
TI  - News and Events of the Week.

PMID- 29821629
TI  - Some Points in the Treatment of Enteric Fever.

PMID- 29821632
TI  - The New Territorial Force Regulations.

PMID- 29821631
TI  - Solid Carbon Dioxide.

PMID- 29821633
TI  - The Hospital World.

PMID- 29821634
TI  - Annotations.

PMID- 29821635
TI  - Some Prescriptions Discussed-II.

PMID- 29821636
TI  - Fresh Air in Railway Carriages.

PMID- 29821637
TI  - The Week's Work.

PMID- 29821638
TI  - Liverpool Royal Infirmary.

PMID- 29821639
TI  - Institutional Notes and News.

PMID- 29821640
TI  - A Bird-Watcher's Camp-I.

PMID- 29821641
TI  - The Results of Stomach Surgery.

PMID- 29821642
TI  - Medical School Scholarships.

PMID- 29821643
TI  - The Week's Work.

PMID- 29821644
TI  - The Hospital World.

PMID- 29821645
TI  - Hospital Contracts and Prices: VI. Domestic.

PMID- 29821646
TI  - Reports on the Hospitals of the United Kingdom: XLVII. Manchester Children's
      Hospital, Pendlebury.

PMID- 29821647
TI  - A Case of Impacted Gall-Stone.

PMID- 29821648
TI  - The Heart during Convalescence from Febrile Disorders.

PMID- 29821649
TI  - Infantile Scurvy, or Barlow's Disease.

PMID- 29821650
TI  - The King's Death.

PMID- 29821651
TI  - Coma Due to Malaria.

PMID- 29821653
TI  - Medical Morphomaniacs.

PMID- 29821652
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821655
TI  - School Clinics in London.

PMID- 29821654
TI  - A Lecture on Lateral Curvature of the Spine.

PMID- 29821656
TI  - Institutional Notes and News.

PMID- 29821657
TI  - Syphilis and Epilepsy.

PMID- 29821659
TI  - Annotations.

PMID- 29821658
TI  - Medical Opinion and Movement.

PMID- 29821660
TI  - News and Events of the Week.

PMID- 29821661
TI  - A Conference on Hospital Diet.

PMID- 29821662
TI  - Exercise and the Pulse-Rate.

PMID- 29821663
TI  - Reports on the Hospitals of the United Kingdom: Some Smaller Hospitals.

PMID- 29821664
TI  - Nature Studies.-VI.

PMID- 29821666
TI  - The Hospital World.

PMID- 29821665
TI  - On the Treatment of Certain Fractures.

PMID- 29821668
TI  - Should Medical Practitioners Dispense?: I. The Professional Standpoint.

PMID- 29821667
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821669
TI  - Holidays for Slum Children.

PMID- 29821670
TI  - Annotations.

PMID- 29821671
TI  - Medical Opinion and Movement.

PMID- 29821672
TI  - The Week's Work.

PMID- 29821673
TI  - The Inheritance of Sex.

PMID- 29821674
TI  - Should Medical Practitioners Dispense?: II. The Pharmacists Point of View.

PMID- 29821675
TI  - Notes on Sanatorium Management.

PMID- 29821676
TI  - Institutional Notes and News.

PMID- 29821677
TI  - Legitimacy from a Medical and Legal Standpoint.

PMID- 29821679
TI  - Institutional Notes and News.

PMID- 29821678
TI  - News and Events of the Week.

PMID- 29821681
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821680
TI  - Chronic Nasal Diphtheria.

PMID- 29821682
TI  - An Easy Method of Destroying Tsetse Flies.

PMID- 29821683
TI  - A Serious Question for the Glasgow Infirmary Managers.

PMID- 29821684
TI  - The Week's Work.

PMID- 29821685
TI  - News and Events of the Week.

PMID- 29821687
TI  - Hospital Contracts and Prices.

PMID- 29821686
TI  - A Complicated Case of Labour.

PMID- 29821688
TI  - Annotations.

PMID- 29821689
TI  - The Middlesex Hospital Appeal.

PMID- 29821690
TI  - Medical Opinion and Movement.

PMID- 29821691
TI  - The Treatment of Epilepsy.

PMID- 29821693
TI  - The Hospital World.

PMID- 29821692
TI  - The Indications for Infusion.

PMID- 29821694
TI  - Should Medical Practitioners Dispense?: III. Prescriber and Dispenser.

PMID- 29821695
TI  - Sclavo's Serum in the Cure of Anthrax without Operation.

PMID- 29821696
TI  - Annals of Quackery-III.

PMID- 29821697
TI  - The Week's Parliament and Publications.

PMID- 29821698
TI  - The Birthday Honours.

PMID- 29821699
TI  - Pre-Asylum Treatment.

PMID- 29821700
TI  - Hospital Fittings.

PMID- 29821701
TI  - The Week's Work.

PMID- 29821702
TI  - Annotations.

PMID- 29821703
TI  - The Death of King Edward VII.

PMID- 29821704
TI  - Recent Progress in Anaesthetics.

PMID- 29821705
TI  - The Hospital World.

PMID- 29821706
TI  - Some Minor Manifestations of Epilepsy.

PMID- 29821707
TI  - The Treatment of Indolent Ulcer.

PMID- 29821708
TI  - News and Events of the Week.

PMID- 29821710
TI  - The Present Position of the Territorial Medical Service.

PMID- 29821709
TI  - Peptone Injections in Haemoglobinuria.

PMID- 29821711
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821712
TI  - Medical Entomology.

PMID- 29821713
TI  - Medical Opinion and Movement.

PMID- 29821714
TI  - Experiences of Long Ago: Erysipelas.

PMID- 29821715
TI  - Hospital Contracts and Prices.

PMID- 29821716
TI  - Reports on the Hospitals of the United Kingdom: XLVIII. The Royal Albert Edward
      Infirmary, Wigan.

PMID- 29821717
TI  - Haematology.-V.

PMID- 29821718
TI  - King Edward's Vaccine Treatment.

PMID- 29821719
TI  - Hospital Sunday in London.

PMID- 29821720
TI  - Hospital Contracts and Prices.

PMID- 29821721
TI  - Medical Opinion and Movement.

PMID- 29821722
TI  - Annotations.

PMID- 29821723
TI  - Operations for Tuberculous Glands in the Neck.

PMID- 29821724
TI  - News and Events of the Week.

PMID- 29821726
TI  - Annals of Quackery-I.

PMID- 29821725
TI  - Reports on the Hospitals of the United Kingdom: L. Leeds Union University.

PMID- 29821727
TI  - The Week's Work.

PMID- 29821728
TI  - Pellagra and Uncinariasis in America.

PMID- 29821730
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821729
TI  - Objections to Compulsory Notification of Phthisis.

PMID- 29821731
TI  - New Appliances and Things Medical.

PMID- 29821733
TI  - An Object-Lesson for the Profession.

PMID- 29821732
TI  - Cancer of the Intestines.

PMID- 29821734
TI  - Failure to Notify Infectious Disease.

PMID- 29821735
TI  - A Plea for More Method in Drug Prescribing.

PMID- 29821736
TI  - Institutional Notes and News.

PMID- 29821737
TI  - The Hospital World.

PMID- 29821738
TI  - Aniline Poisoning and Its Treatment.

PMID- 29821739
TI  - The Treatment of Everyday Cases.

PMID- 29821740
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821741
TI  - News and Events of the Week.

PMID- 29821743
TI  - The Week's Work.

PMID- 29821742
TI  - Tropical Haematology.-III.

PMID- 29821745
TI  - Operations for the Results of Cholelithiasis.

PMID- 29821744
TI  - Difficult Diagnosis in a Case of Pregnancy.

PMID- 29821746
TI  - The Clinical Examination of the Chest.

PMID- 29821747
TI  - The General Hospital, Toronto.

PMID- 29821748
TI  - Reports on the Hospitals of the United Kingdom: Leatherhead (Victoria Memorial)
      Cottage Hospital; The Bridgewater Hospital; Wells General Hospital.

PMID- 29821749
TI  - Peripheral Neuritis Due to Sulphide of Carbon.

PMID- 29821750
TI  - Foreign Bodies in the Ear.

PMID- 29821751
TI  - The Coroners' Commission.

PMID- 29821752
TI  - Hospitals and Poor Law Reform.

PMID- 29821753
TI  - Albuminous and Non-Albuminous Sputa.

PMID- 29821754
TI  - New Appliances & Things Medical.

PMID- 29821755
TI  - Medical Opinion and Movement.

PMID- 29821756
TI  - Institutional Notes and News.

PMID- 29821757
TI  - Annotations.

PMID- 29821758
TI  - Flies and Their Breeding Places.

PMID- 29821759
TI  - London University and the Royal Colleges.

PMID- 29821760
TI  - Pure Food.

PMID- 29821761
TI  - The Hospital World.

PMID- 29821763
TI  - Annotations.

PMID- 29821762
TI  - A Home for Feeble-Minded Girls.

PMID- 29821764
TI  - Medical Opinion and Movement.

PMID- 29821765
TI  - The Treatment of Tuberculous Fistulae by Potassium Permanganate.

PMID- 29821767
TI  - The Good Old Times.

PMID- 29821766
TI  - Eosinophilia in a Case of Strongyloides Stercoralis.

PMID- 29821768
TI  - The Combat against National Deterioration: Lessons Learnt in the Out-Patient
      Department.

PMID- 29821769
TI  - News and Events of the Week.

PMID- 29821771
TI  - Institutional Notes and News.

PMID- 29821770
TI  - The Week's Parliament and Publications.

PMID- 29821772
TI  - The Week's Work.

PMID- 29821773
TI  - "The Christian World" and Mr. Alabone.

PMID- 29821774
TI  - Exercises and the Blood-Pressure in Heart Cases.

PMID- 29821775
TI  - By the Way.

PMID- 29821776
TI  - School Children: Some Reflections on Present Arrangements.

PMID- 29821777
TI  - The Hospital World.

PMID- 29821778
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821779
TI  - British Pharmaceutical Conference.

PMID- 29821780
TI  - Mental Healing.

PMID- 29821781
TI  - The Medico-Psychological Association.

PMID- 29821783
TI  - Laryngeal Papillomata in Children.

PMID- 29821782
TI  - The L.C.C. and Public Slaughter-Houses.

PMID- 29821784
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29821785
TI  - Aortic Incompetence and Its Lessons.

PMID- 29821786
TI  - Nonconformity and Medicine.

PMID- 29821787
TI  - The Hospital World.

PMID- 29821788
TI  - The Week's Work.

PMID- 29821789
TI  - The Cause of Cancer.

PMID- 29821790
TI  - Premature Burial.

PMID- 29821791
TI  - Medical Opinion and Movement.

PMID- 29821792
TI  - Haemoptysis-II.

PMID- 29821793
TI  - Bolton Infirmary Inquiry.

PMID- 29821794
TI  - Suppository Bases, Especially for the Tropics.

PMID- 29821795
TI  - The Year's Work as Shown in Local Reports.

PMID- 29821796
TI  - News and Events of the Week.

PMID- 29821797
TI  - Institutional Notes and News.

PMID- 29821798
TI  - Potassium Permanganate in Tuberculous Fistulae.

PMID- 29821799
TI  - The Fusion of Medicine and Surgery.

PMID- 29821800
TI  - The Week's Parliament and Publications.

PMID- 29821801
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821802
TI  - Annotations.

PMID- 29821803
TI  - A Minister of Public Health.

PMID- 29821804
TI  - A Modern French Analysis of the English Mind.

PMID- 29821806
TI  - Prices for Surgical Dressings.

PMID- 29821805
TI  - Most Serious Objection.

PMID- 29821808
TI  - Twenty-Five Tapeworms in One Patient.

PMID- 29821807
TI  - New Children's Wards at the Royal Portsmouth, Portsea, and Gosport Hospital.

PMID- 29821809
TI  - Hospital Contracts and Prices.

PMID- 29821811
TI  - The Hospital World.

PMID- 29821810
TI  - Reports on the Hospitals of the United Kingdom: XLIX. Radcliffe Infirmary and
      County Hospital, Oxford.

PMID- 29821812
TI  - King George V.

PMID- 29821813
TI  - The Care of the Motor-Car Body.

PMID- 29821815
TI  - Occasional Jerks of Local Muscle Groups as a Sign of Epilepsy.

PMID- 29821814
TI  - Common Difficulties in Forceps Delivery.

PMID- 29821816
TI  - Electrical Treatment of Naevi.

PMID- 29821817
TI  - Medical Opinion and Movement.

PMID- 29821819
TI  - The British Medical Benevolent Fund Guild.

PMID- 29821818
TI  - The Week's Work.

PMID- 29821821
TI  - Photography.

PMID- 29821820
TI  - The Vaccine Treatment of the Common Cold.

PMID- 29821822
TI  - Food Adulteration.

PMID- 29821823
TI  - Annotations.

PMID- 29821824
TI  - The Death of King Edward VII.

PMID- 29821825
TI  - The Objection Answered.

PMID- 29821826
TI  - Institutional Notes and News.

PMID- 29821827
TI  - The Possibility of Influencing the Malignant Neoplasmata by Inoculation.

PMID- 29821829
TI  - Annotations.

PMID- 29821828
TI  - Institutional Notes and News.

PMID- 29821831
TI  - Reports on the Hospitals of the United Kingdom: XLIII. Chorlton Union Infirmary,
      West Didsbury (Manchester).

PMID- 29821830
TI  - Hospital Contracts and Prices: IV. Surgical Dressings.

PMID- 29821832
TI  - The Hospital for Sick Children, Toronto.

PMID- 29821833
TI  - Diagram of the Weekly Death-Rate in 1910.

PMID- 29821834
TI  - Spiritualism and Insanity.

PMID- 29821835
TI  - The Doctor in Fiction.

PMID- 29821836
TI  - The Claims of Tuberculosis.

PMID- 29821838
TI  - Haematology.-IV.

PMID- 29821837
TI  - Christian Science.

PMID- 29821839
TI  - The Hospital World.

PMID- 29821840
TI  - News and Events of the Week.

PMID- 29821841
TI  - Electric Lifts for Hospital Use.

PMID- 29821842
TI  - Dysmenorrhoea.

PMID- 29821843
TI  - The Week's Work.

PMID- 29821844
TI  - Post-Mortem Examinations.

PMID- 29821845
TI  - Medical Opinion and Movement.

PMID- 29821846
TI  - Haematuria in Renal Tuberculosis.

PMID- 29821847
TI  - New Appliances and Things Medical.

PMID- 29821848
TI  - The Supervision of Hospital Alterations.

PMID- 29821849
TI  - Hospital Accommodation for Diphtheria Patients.

PMID- 29821851
TI  - Dynamic Catalepsy.

PMID- 29821850
TI  - Lunacy Reform.

PMID- 29821852
TI  - The King's Last Illness.

PMID- 29821853
TI  - Institutional Notes and News.

PMID- 29821855
TI  - The Hospital World.

PMID- 29821854
TI  - His Majesty's Practical Interest in Science.

PMID- 29821856
TI  - From All Quarters.

PMID- 29821857
TI  - Tight Neck-Clothing.

PMID- 29821859
TI  - Hospitals and the Law of Negligence.

PMID- 29821858
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821860
TI  - Dysmenorrhoea.

PMID- 29821861
TI  - Reports on the Hospitals of the United Kingdom: XLIV. Staffordshire General
      Infirmary, Stafford; Two Cottage Hospitals.

PMID- 29821862
TI  - A Complaint of a Criticism.

PMID- 29821864
TI  - New Appliances & Things Medical.

PMID- 29821863
TI  - The Late King Edward VII.

PMID- 29821866
TI  - His Late Majesty as Hospital Patron.

PMID- 29821865
TI  - King Edward VII.

PMID- 29821868
TI  - Long Live the King!

PMID- 29821867
TI  - Medical Degrees at Cambridge.

PMID- 29821869
TI  - The Week's Work.

PMID- 29821870
TI  - Hospital Contracts and Prices: V. Surgical Instruments, Wines, and Sundries.

PMID- 29821871
TI  - Annotations.

PMID- 29821872
TI  - News and Events of the Week.

PMID- 29821873
TI  - News and Events of the Week.

PMID- 29821874
TI  - Venereal Prophylaxis.

PMID- 29821875
TI  - New Appliances & Things Medical.

PMID- 29821876
TI  - Hospital Contracts and Prices.

PMID- 29821877
TI  - Purpura.

PMID- 29821878
TI  - The Hospital World.

PMID- 29821879
TI  - Institutional Notes and News.

PMID- 29821880
TI  - Professional Benevolence.

PMID- 29821881
TI  - Medical Opinion and Movement.

PMID- 29821882
TI  - The Nauheim Treatment in Heart Cases.

PMID- 29821883
TI  - The Influence of Hospital Sunday.

PMID- 29821884
TI  - Nasal Neuroses.

PMID- 29821885
TI  - Some Clinical Forms of Tabes.

PMID- 29821887
TI  - Fibrolysin in Obesity.

PMID- 29821886
TI  - Annotations.

PMID- 29821889
TI  - Annals of Quackery-II.

PMID- 29821888
TI  - Anaesthetics and Apparent Death.

PMID- 29821891
TI  - The Week's Work.

PMID- 29821890
TI  - Reports on the Hospitals of the United Kingdom: LI. Royal Alexandra Hospital for
      Sick Children, Brighton.

PMID- 29821892
TI  - Haematology-VI.

PMID- 29821893
TI  - New Appliances & Things Medical.

PMID- 29821894
TI  - Aluminium Acetate Solution in the Treatment of Wounds.

PMID- 29821895
TI  - The Payment of Hospital Staffs.-A Rejoinder to Dr. Heron.

PMID- 29821896
TI  - The Tactical Employment of the Medical Service in War Operations.

PMID- 29821898
TI  - Parliament and Publications.

PMID- 29821897
TI  - Gas and Electricity.

PMID- 29821899
TI  - Institutional Notes and News.

PMID- 29821900
TI  - Paroxysmal Haemoglobinuria.

PMID- 29821902
TI  - Camp Life for Medical Students.

PMID- 29821901
TI  - Covenants Relating to Hospitals.

PMID- 29821903
TI  - The Physical Treatment of Sciatica.

PMID- 29821904
TI  - Cancer Research.

PMID- 29821905
TI  - Legitimacy from a Medical and Legal Standpoint.-II.

PMID- 29821906
TI  - By the Way.

PMID- 29821907
TI  - Annotations.

PMID- 29821908
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821910
TI  - Reminiscences of Half a Century Ago.

PMID- 29821909
TI  - The Diagnosis and Prognosis of Acute Pneumonia-II.

PMID- 29821911
TI  - News and Events of the Week.

PMID- 29821912
TI  - The Week's Work.

PMID- 29821913
TI  - Medical Opinion and Movement.

PMID- 29821914
TI  - Poisoning by Organic Compounds of Arsenic.

PMID- 29821915
TI  - Post-Partum Haemorrhage.

PMID- 29821916
TI  - The Week's Parliament and Publications.

PMID- 29821917
TI  - Erratum: Potassium Permanganate in Tuberculous Fistulae.
AB  - [This corrects the article on p. 462a in vol. 48.].

PMID- 29821919
TI  - The Medical Profession and Secret Commissions.

PMID- 29821918
TI  - Appendicitis: Some Points about the Non-Operative Treatment.

PMID- 29821921
TI  - By the Way.

PMID- 29821920
TI  - The Voluntary Aid Detachments.

PMID- 29821922
TI  - New Appliances & Things Medical.

PMID- 29821923
TI  - Medical Opinion and Movement.

PMID- 29821924
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29821925
TI  - News and Events of the Week.

PMID- 29821927
TI  - Annotations.

PMID- 29821926
TI  - Who Benefits? Or, Cash, Not Criticism, for Our Hospitals.

PMID- 29821928
TI  - Institutional Notes and News.

PMID- 29821929
TI  - Cheltenham General Hospital.

PMID- 29821930
TI  - Theories of Sex.

PMID- 29821931
TI  - The Hospital World.

PMID- 29821933
TI  - Asphyxia Neonatorum.

PMID- 29821932
TI  - The Combat against National Deterioration: I. The Work of the Lady Almoner.

PMID- 29821935
TI  - Bone Deposits in Carcinoma of the Breast.

PMID- 29821934
TI  - The Week's Work.

PMID- 29821936
TI  - The English Conjoint Course.

PMID- 29821937
TI  - Qualification and Registration.

PMID- 29821938
TI  - Special Departments.

PMID- 29821939
TI  - Graduate Study in Scotland and Ireland.

PMID- 29821940
TI  - London Post-Graduate Institutions.

PMID- 29821941
TI  - The London University Course.

PMID- 29821942
TI  - Opportunities for Graduate Study in Special Hospitals.

PMID- 29821943
TI  - Authority and the Medical Student.

PMID- 29821945
TI  - Handbooks for Senior Students and Practitioners.

PMID- 29821944
TI  - Public Health Diplomas.

PMID- 29821946
TI  - The Cambridge University Course.

PMID- 29821947
TI  - Ward and Clinical Work.

PMID- 29821948
TI  - The Medical Schools of the United Kingdom.

PMID- 29821949
TI  - The Preliminary Education of a Medical Man.

PMID- 29821950
TI  - Medical Journalism.

PMID- 29821951
TI  - A Prologue of Practice.

PMID- 29821952
TI  - The Study of Languages.

PMID- 29821953
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29821955
TI  - The Study of Tropical Medicine.

PMID- 29821954
TI  - Opportunities for Post-Graduate Study.

PMID- 29821956
TI  - Oxford University.

PMID- 29821957
TI  - Higher Diplomas.

PMID- 29821958
TI  - The Public Services.

PMID- 29821959
TI  - A Medical Career and Its Prospects.

PMID- 29821960
TI  - News and Events of the Week.

PMID- 29821961
TI  - Some Health Reports-I.

PMID- 29821962
TI  - A Bird-Watcher's Camp-II.

PMID- 29821963
TI  - The Prevention of Cholera.

PMID- 29821964
TI  - The Cholera.

PMID- 29821965
TI  - The Asylum World.

PMID- 29821966
TI  - The Treatment of Cholera.

PMID- 29821967
TI  - The Week's Work.

PMID- 29821969
TI  - Institutional Notes and News.

PMID- 29821968
TI  - The Opening of the Medical Schools.

PMID- 29821970
TI  - Medical Opinion and Movement.

PMID- 29821971
TI  - The Hospital World.

PMID- 29821972
TI  - Myelogenous Leukaemia and Its Treatment.

PMID- 29821973
TI  - Parliament and Publications.

PMID- 29821974
TI  - A Note on Continuous Proctoclysis.

PMID- 29821975
TI  - New Appliances & Things Medical.

PMID- 29821976
TI  - Cholera.

PMID- 29821977
TI  - The Whole Truth.

PMID- 29821978
TI  - Japan-British Exhibition Awards.

PMID- 29821980
TI  - Annotations.

PMID- 29821979
TI  - Osteopathy.

PMID- 29821981
TI  - Haematology-VIII.

PMID- 29821982
TI  - Some Prescriptions Discussed-III.

PMID- 29821984
TI  - A War Office Advisory Committee for the Voluntary Aid Detachments.

PMID- 29821983
TI  - Heliotropism.

PMID- 29821985
TI  - The Hospital World.

PMID- 29821987
TI  - News and Events of the Week.

PMID- 29821986
TI  - The British Medical Association Meeting.

PMID- 29821988
TI  - The Future of the Hospitals.

PMID- 29821989
TI  - The Week's Work.

PMID- 29821990
TI  - How to Puncture the Maxillary Antrum.

PMID- 29821991
TI  - King George's Visit to the London Hospital.

PMID- 29821993
TI  - The Future of the Hospitals.

PMID- 29821992
TI  - The Local Application of Salicylates.

PMID- 29821994
TI  - Medical Opinion and Movement.

PMID- 29821995
TI  - Enucleation of the Tonsil.

PMID- 29821996
TI  - A Burmese Practice of Medicine.

PMID- 29821997
TI  - By the Way.

PMID- 29821998
TI  - The Week's Parliament and Publications.

PMID- 29821999
TI  - Annotations.

PMID- 29822000
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29822001
TI  - Institutional Notes and News.

PMID- 29822002
TI  - Haematology-VII.

PMID- 29822003
TI  - Polyuria in Sciatica.

PMID- 29822004
TI  - Institutional Notes and News.

PMID- 29822005
TI  - Doctors and the Speed Limit.

PMID- 29822006
TI  - New Appliances and Things Medical.

PMID- 29822007
TI  - Canadian Notes.

PMID- 29822008
TI  - Testimonials.

PMID- 29822009
TI  - Successful Passage per Rectum of a Key.

PMID- 29822010
TI  - Annotations.

PMID- 29822011
TI  - Persistence of the Knee-Jerks in Tabes Dorsalis.

PMID- 29822013
TI  - The Week's Work.

PMID- 29822012
TI  - Open-Air Sanatorium and Graduated Labour.

PMID- 29822014
TI  - An All-Metal Inhaler.

PMID- 29822015
TI  - Chronic Laryngitis.

PMID- 29822016
TI  - Annals of Quackery-IV.

PMID- 29822017
TI  - An Educational Problem.

PMID- 29822018
TI  - Premature Burial.

PMID- 29822019
TI  - The Leeds Maternity Hospital.

PMID- 29822020
TI  - Medical Opinion and Movement.

PMID- 29822022
TI  - The Week's Parliament and Publications.

PMID- 29822021
TI  - The Hospital World.

PMID- 29822023
TI  - Nonconformity of Medicine.

PMID- 29822024
TI  - Haemoptysis.

PMID- 29822025
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29822026
TI  - News and Events of the Week.

PMID- 29822027
TI  - Nature Studies-VII.

PMID- 29822028
TI  - Maternity Pensions.

PMID- 29822030
TI  - Medical Opinion and Movement.

PMID- 29822029
TI  - Crewkerne Hospital-An Explanation.

PMID- 29822031
TI  - Mental Treatment.

PMID- 29822032
TI  - Jacksonian Epilepsy in Idiopathic Epilepsy.

PMID- 29822033
TI  - The Week's Work.

PMID- 29822034
TI  - By the Way.

PMID- 29822036
TI  - Inequality in the Length of the Lower Extremities.

PMID- 29822035
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29822037
TI  - Pneumococcal Pyaemia.

PMID- 29822038
TI  - Inquest on a Nurse.

PMID- 29822039
TI  - The Mystery of the Royal Touch.

PMID- 29822041
TI  - Annotations.

PMID- 29822040
TI  - The "Christian World" and Consumption Sanatoriums.

PMID- 29822042
TI  - News and Events of the Week.

PMID- 29822043
TI  - Prolapse and Procidentia.

PMID- 29822045
TI  - Parliament and Publications.

PMID- 29822044
TI  - The "Christian World" and Consumption Sanatoriums.

PMID- 29822046
TI  - The Hospital World.

PMID- 29822047
TI  - Pauperism and Crime.

PMID- 29822048
TI  - New Appliances and Things Medical.

PMID- 29822049
TI  - The Choice of a Doctor's Motor-Car.

PMID- 29822050
TI  - Local History as a Relaxation for the Practitioner.

PMID- 29822051
TI  - Bethlem and Insanity.

PMID- 29822052
TI  - Acute Streptococcal Jaundice.

PMID- 29822053
TI  - The Diagnosis and Prognosis of Acute Pneumonia-I.

PMID- 29822054
TI  - Institutional Notes and News.

PMID- 29822056
TI  - Miss Nightingale.

PMID- 29822055
TI  - The Future of Hospitals: A Disclaimer.

PMID- 29822057
TI  - Mosquitoes.

PMID- 29822058
TI  - Florence Nightingale, O.M.

PMID- 29822059
TI  - Annotations.

PMID- 29822060
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29822061
TI  - The Hospital World.

PMID- 29822062
TI  - The Complications of Scarlet Fever.

PMID- 29822064
TI  - Bi-Nitrobenzene Poisoning.

PMID- 29822063
TI  - The Week's Work.

PMID- 29822065
TI  - Circumcision and Its Advantages.

PMID- 29822066
TI  - New Appliances and Things Medical.

PMID- 29822067
TI  - Medical Opinion and Movement.

PMID- 29822068
TI  - Anti-Vivisection Hospital.

PMID- 29822069
TI  - The Medical Unit of the O.T.C.

PMID- 29822070
TI  - Preparation 606.

PMID- 29822071
TI  - News and Events of the Week.

PMID- 29822072
TI  - Hospitals and the Law.

PMID- 29822073
TI  - Cold-Storage Problems.

PMID- 29822074
TI  - Authorship and Authority.

PMID- 29822075
TI  - London Hospitals of To-Day.

PMID- 29822077
TI  - The Week's Work.

PMID- 29822076
TI  - The Hospital Problem: Weighing and Venturing.

PMID- 29822079
TI  - News and Events of the Week.

PMID- 29822078
TI  - The Rational Treatment of Common Symptoms among Infants.

PMID- 29822081
TI  - By the Way.

PMID- 29822080
TI  - The Late King and the Hospitals.

PMID- 29822082
TI  - Purifying Buildings by Ozone.

PMID- 29822083
TI  - The Hospital World.

PMID- 29822085
TI  - Medical Opinion and Movement.

PMID- 29822084
TI  - The Week in the Courts.

PMID- 29822086
TI  - A Charge of Malingering.

PMID- 29822087
TI  - The Choice of a Hospital Secretary.

PMID- 29822088
TI  - Annotations.

PMID- 29822089
TI  - Water-Supply.

PMID- 29822090
TI  - In General Practice.

PMID- 29822091
TI  - Institutional Notes and News.

PMID- 29822092
TI  - White Bread and Its Impurities.

PMID- 29822093
TI  - Work and Hobbies.

PMID- 29822094
TI  - The Hospital Problem: Bogeys.

PMID- 29822095
TI  - The Week in the Courts.

PMID- 29822096
TI  - The Hospital World.

PMID- 29822097
TI  - A Dead Philanthropist.

PMID- 29822098
TI  - Public Hospitals and Their Maintenance.

PMID- 29822099
TI  - Removal of Plaster-Of-Paris Bandages.

PMID- 29822100
TI  - The Treatment of OEdema in Chronic Nephritis.

PMID- 29822101
TI  - Annotations.

PMID- 29822102
TI  - Nurses' Home, Salop Infirmary, Shrewsbury.

PMID- 29822104
TI  - Medical Opinion and Movement.

PMID- 29822103
TI  - Paraplegia in Connection with Potts' Disease.

PMID- 29822105
TI  - Hospitals of To-Day.

PMID- 29822106
TI  - New Appliances & Things Medical.

PMID- 29822107
TI  - The Practice Market : IV. Medical Partnership Agreements.

PMID- 29822108
TI  - The Week's Work.

PMID- 29822109
TI  - Institutional Notes and News.

PMID- 29822110
TI  - News and Events of the Week.

PMID- 29822111
TI  - Eminent Chairmen Series : Sir George White, Bart., President and Treasurer of
      Bristol Royal Infirmary.

PMID- 29822112
TI  - News and Events of the Week.

PMID- 29822113
TI  - The Views of Hospital Secretaries.

PMID- 29822115
TI  - Special Interview with Mr. Conrad W. Thies.

PMID- 29822114
TI  - A Complete Ward Unit for a Modern General Hospital.

PMID- 29822116
TI  - The Artificial Illumination of the Small Hospital.

PMID- 29822117
TI  - Some Points on Various Affections of the Lungs.-II.

PMID- 29822118
TI  - Home and Continental Spas : V. Harrogate.

PMID- 29822119
TI  - Institutional Notes and News.

PMID- 29822120
TI  - Racial Immunity.

PMID- 29822121
TI  - The National Insurance Bill.

PMID- 29822122
TI  - The Week's Work.

PMID- 29822123
TI  - The Hospital World.

PMID- 29822124
TI  - The Seventieth Anniversary of the Pharmaceutical Society.

PMID- 29822125
TI  - Medical Opinion and Movement.

PMID- 29822126
TI  - Contract-Provident Medical Service.

PMID- 29822127
TI  - Annotations.

PMID- 29822128
TI  - By the Way.

PMID- 29822129
TI  - The Week in the Courts.

PMID- 29822130
TI  - The Hospital World.

PMID- 29822131
TI  - Institutional Notes and News.

PMID- 29822132
TI  - The Week's Work.

PMID- 29822133
TI  - Metropolitan Radical Federation and the Funds.

PMID- 29822134
TI  - Eminent Chairmen Series : VII. Perceval Alleyne Nairne, Chairman of the Seamen's
      Hospital Society.

PMID- 29822135
TI  - News and Events of the Week.

PMID- 29822137
TI  - Home and Continental Spas : IV. Oeynhausen.

PMID- 29822136
TI  - The Rational Treatment of Common Symptoms among Infants-II.

PMID- 29822138
TI  - Practitioners, the Hospitals, and the Poor Law.

PMID- 29822139
TI  - Annotations.

PMID- 29822140
TI  - Hospitals of To-Day.

PMID- 29822141
TI  - Soldier's Heart.

PMID- 29822142
TI  - Some Spinal Cord Lesions: II. Amyotrophic Lateral Sclerosis.

PMID- 29822143
TI  - Medical Opinion and Movement.

PMID- 29822144
TI  - Cold-Storage Problems.

PMID- 29822145
TI  - Problems of Hospital Policy.

PMID- 29822146
TI  - The National Insurance Scheme.

PMID- 29822147
TI  - Hospitals of To-Day.

PMID- 29822148
TI  - Onchocerciasis.

PMID- 29822149
TI  - Fire Extinguishing Appliances.

PMID- 29822151
TI  - Institutional Notes and News.

PMID- 29822150
TI  - The Minimum Age for School Children.

PMID- 29822152
TI  - The Hospital World.

PMID- 29822153
TI  - The Week's Work.

PMID- 29822154
TI  - Avoidable Accidents.

PMID- 29822155
TI  - On Position during Anaesthesia.

PMID- 29822156
TI  - A Few Points Concerning Affections of the Lungs.

PMID- 29822158
TI  - The Insurance Bill.

PMID- 29822157
TI  - A Complete Ward Unit for a Modern Hospital.

PMID- 29822159
TI  - Rotheln or German Measles.

PMID- 29822160
TI  - Parliament and Publications.

PMID- 29822161
TI  - Medical Opinion and Movement.

PMID- 29822162
TI  - Annotations.

PMID- 29822164
TI  - Doctors and the Bill.

PMID- 29822163
TI  - Hospitals' Association Conference.

PMID- 29822165
TI  - Some Omissions in the National Insurance Bill.

PMID- 29822167
TI  - Medical Opinion and Movement.

PMID- 29822166
TI  - Appendicitis and Pseudo-Appendicitis in Certain Infectious Diseases.-II.

PMID- 29822168
TI  - Hospital Building.

PMID- 29822169
TI  - Hospitals and State Insurance.

PMID- 29822170
TI  - The Views of Hospital Secretaries.

PMID- 29822171
TI  - The Hospital World.

PMID- 29822172
TI  - The National Insurance Bill.

PMID- 29822173
TI  - The Week's Work.

PMID- 29822174
TI  - News and Events of the Week.

PMID- 29822175
TI  - Minor Injuries in Children.

PMID- 29822176
TI  - A Warning.

PMID- 29822177
TI  - Institutional Notes and News.

PMID- 29822178
TI  - The British Hospitals' Association Conference.

PMID- 29822179
TI  - The British Hospitals' Association.

PMID- 29822180
TI  - Annotations.

PMID- 29822181
TI  - Hospitals and the Treatment of Children under the Insurance Bill.

PMID- 29822182
TI  - How Hospitals Help the Englishman Abroad.

PMID- 29822184
TI  - The Needs of To-Day.

PMID- 29822183
TI  - 1910. A Year's Work in the Hospitals and Medical Charities of London.

PMID- 29822185
TI  - The Convalescent Home as a Hospital Department.

PMID- 29822186
TI  - Hospitals and the Sunday Fund.

PMID- 29822187
TI  - The Income of Our Hospitals and Dispensaries.

PMID- 29822188
TI  - Why Should I Help the Hospitals?

PMID- 29822189
TI  - Two-And-A-Quarter Million Sufferers Helped by the Hospitals.

PMID- 29822190
TI  - The Queen's Visit to the Coombe Hospital.

PMID- 29822191
TI  - Medicine and the State.

PMID- 29822192
TI  - The Committee Stage of the National Insurance Bill.

PMID- 29822193
TI  - The Practice Market.-VII: The Relations between the Purchaser and the Agent.

PMID- 29822194
TI  - Annotations.

PMID- 29822195
TI  - The Week's Work.

PMID- 29822196
TI  - News and Events of the Week.

PMID- 29822197
TI  - Institutional Notes and News.

PMID- 29822198
TI  - The German System.

PMID- 29822199
TI  - Pharmacists and the Insurance Bill.

PMID- 29822200
TI  - Medical Opinion and Movement.

PMID- 29822201
TI  - The Voluntary Hospitals in Danger; "Wake Up" Everybody!

PMID- 29822202
TI  - The Canadian Hospital Association.

PMID- 29822204
TI  - Deaths at Cricket.

PMID- 29822203
TI  - Some Points in the Treatment of Diphtheritic Laryngeal Obstruction.-I.

PMID- 29822205
TI  - The Hospital World.

PMID- 29822206
TI  - Hospital Officers' Association Visit to Richmond.

PMID- 29822208
TI  - Sulphaemoglobinaemia.

PMID- 29822207
TI  - A Complete Ward Unit for a Modern General Hospital.

PMID- 29822210
TI  - The Position of the Ormond Street Hospital.

PMID- 29822209
TI  - Maternity Insurance.

PMID- 29822211
TI  - Institutional Notes and News.

PMID- 29822212
TI  - Annotations.

PMID- 29822214
TI  - The Week's Work.

PMID- 29822213
TI  - Hospital Versus Private Practice.

PMID- 29822215
TI  - The Hospitals and the Insurance Scheme.

PMID- 29822216
TI  - Medical Opinion and Movement.

PMID- 29822217
TI  - Cerebral Congestion and Tight Neck-Clothing.

PMID- 29822219
TI  - The Hospital World.

PMID- 29822218
TI  - The National Insurance Bill and the Voluntary Hospitals.

PMID- 29822221
TI  - The Views of Hospital Secretaries.

PMID- 29822220
TI  - Retroversion of the Uterus Complicated by a Cystic Ovary and Salpingitis.

PMID- 29822222
TI  - The Annual Cost of a Doctor's Motor-Car.

PMID- 29822223
TI  - The Present Hospital at Melbourne.

PMID- 29822224
TI  - Discussion at the Medico-Legal Society.

PMID- 29822225
TI  - Parliament and Publications.

PMID- 29822226
TI  - Some Experiences of a Bird Collector.

PMID- 29822228
TI  - News and Events of the Week.

PMID- 29822227
TI  - Hospitals and Flannelette.

PMID- 29822229
TI  - News and Events of the Week.

PMID- 29822230
TI  - The Week's Work.

PMID- 29822231
TI  - The Serological Test for the Blood.

PMID- 29822232
TI  - Medical Opinion and Movement.

PMID- 29822234
TI  - The Hospital Problem: The Future of the Funds.

PMID- 29822233
TI  - The Ancient Office of Coroner.

PMID- 29822235
TI  - Hospitals of To-Day.

PMID- 29822236
TI  - Tubercle Bacilli in Sputum.

PMID- 29822237
TI  - L'hopital Saint-Louis De Paris (1607-1911).

PMID- 29822238
TI  - Functional Dyspepsia.

PMID- 29822239
TI  - The Hospital World.

PMID- 29822240
TI  - Institutional Notes and News.

PMID- 29822241
TI  - A Complete Ward Unit for a Modern General Hospital.

PMID- 29822243
TI  - Paraplegia in Connection with Potts' Disease.

PMID- 29822242
TI  - Movable Kidneys.

PMID- 29822244
TI  - Annotations.

PMID- 29822245
TI  - The Territorial Medical Officer's Examinations.

PMID- 29822247
TI  - Appendicitis in Children.-II.

PMID- 29822246
TI  - Martyrs to Science and the Workmen's Compensation Act.

PMID- 29822249
TI  - The Hospital World.

PMID- 29822248
TI  - The Home Hospitals Association for Paying Patients.

PMID- 29822250
TI  - "The Hospital" Medico-Sociological Supplement (No. IV.).

PMID- 29822251
TI  - News and Events of the Week.

PMID- 29822252
TI  - Medical Opinion and Movement.

PMID- 29822253
TI  - New Appliances & Things Medical.

PMID- 29822254
TI  - Wanted-Co-Operation.

PMID- 29822255
TI  - Annotations.

PMID- 29822256
TI  - The Week's Work.

PMID- 29822257
TI  - Institutional Notes and News.

PMID- 29822258
TI  - The Sign of the Spinal Muscles in Pleurisy.

PMID- 29822259
TI  - Parliament and Publications.

PMID- 29822260
TI  - The League of Mercy.

PMID- 29822261
TI  - The Week in the Courts.

PMID- 29822263
TI  - New Appliances & Things Medical.

PMID- 29822262
TI  - Water Supply: III. Storage.

PMID- 29822264
TI  - King Edward's Hospital Fund for London.

PMID- 29822265
TI  - The Standing of the Profession.

PMID- 29822266
TI  - The Hospital Sunday Fund.

PMID- 29822267
TI  - News and Events of the Week.

PMID- 29822268
TI  - The Week's Work.

PMID- 29822269
TI  - Stage Management at a Hospital.

PMID- 29822270
TI  - The Practice Market: III. Taking a Partner.

PMID- 29822271
TI  - Appendicitis in Children.-I.

PMID- 29822272
TI  - Causes Preventive of Maternal Nursing.

PMID- 29822273
TI  - Annotations.

PMID- 29822274
TI  - Ordinary Infant Dietaries.

PMID- 29822275
TI  - Institutional Notes and News.

PMID- 29822276
TI  - A Cruise to the Canaries.

PMID- 29822277
TI  - The Hospital World.

PMID- 29822278
TI  - Medical Opinion and Movement.

PMID- 29822279
TI  - Parliament and Publications.

PMID- 29822280
TI  - The King's Fund and Hospitals with Medical Schools.

PMID- 29822281
TI  - The Committee Stage of the National Insurance Bill.

PMID- 29822283
TI  - Proptosis of the Left Broad Ligament as a Cause of Constipation.

PMID- 29822282
TI  - Medical Opinion and Movement.

PMID- 29822284
TI  - The Hospital World.

PMID- 29822285
TI  - Institutional Notes and News.

PMID- 29822286
TI  - Bee-Keeping as a Relaxation.

PMID- 29822287
TI  - Some Points in the Treatment of Diphtheritic Laryngeal Obstruction.-II.

PMID- 29822288
TI  - A New Sign of Scarlet Fever.

PMID- 29822289
TI  - The House of Commons and the Voluntary Hospitals.

PMID- 29822290
TI  - State Insurance.

PMID- 29822291
TI  - Some Spinal Cord Lesions.-III: Insular, Multiple, or Disseminate Sclerosis.

PMID- 29822292
TI  - The King's Fund and the Bill.

PMID- 29822293
TI  - The National Insurance Scheme and the Supply of Drugs.

PMID- 29822294
TI  - Annotations.

PMID- 29822295
TI  - The National Insurance Bill.

PMID- 29822296
TI  - Special Meeting of the Hospital Saturday Fund.

PMID- 29822297
TI  - Modern Osteopathy.

PMID- 29822298
TI  - Field Cookery in the Territorial Force.

PMID- 29822299
TI  - New Appliances.

PMID- 29822300
TI  - The Week's Work.

PMID- 29822301
TI  - Women and the Insurance Bill.

PMID- 29822303
TI  - The Voluntary Hospitals and the House of Commons.

PMID- 29822302
TI  - The Voluntary Principle and the Bill.

PMID- 29822304
TI  - Recent Alterations in the Insurance Bill.

PMID- 29822305
TI  - Some Spinal Cord Lesions.-IV: Syringomyelia.

PMID- 29822306
TI  - The Week's Work.

PMID- 29822307
TI  - Medical Opinion and Movement.

PMID- 29822309
TI  - Cooking in the Territorial Medical Service.

PMID- 29822308
TI  - The National Insurance Bill.

PMID- 29822310
TI  - The Feeding of School Children.

PMID- 29822311
TI  - A Hospital Officer's Career.

PMID- 29822312
TI  - Annotations.

PMID- 29822313
TI  - Progress of the National Insurance Bill.

PMID- 29822314
TI  - Bone Transplantation.

PMID- 29822316
TI  - The Metropolitan Hospital Sunday Fund.

PMID- 29822315
TI  - Injection of the Broad Ligaments for Prolapsus Uteri.-II.

PMID- 29822317
TI  - The Hospital World.

PMID- 29822318
TI  - New Appliances & Things Medical.

PMID- 29822320
TI  - News and Events of the Week.

PMID- 29822319
TI  - Resignation of a Dispensing Staff.

PMID- 29822321
TI  - Westminster Hospital Stand.

PMID- 29822322
TI  - Medical Opinion and Movement.

PMID- 29822324
TI  - The Week's Work.

PMID- 29822323
TI  - The Manchester Meeting.

PMID- 29822326
TI  - The National Insurance Bill.

PMID- 29822325
TI  - The Use of Paraffin in Scars and Other Facial Blemishes.

PMID- 29822327
TI  - Hospitals and State Aid.-III: Conditions under which Government Aid is Given to
      Hospitals.

PMID- 29822328
TI  - The Hospital World.

PMID- 29822330
TI  - Health Committees under the Insurance Bill.

PMID- 29822329
TI  - Annotations.

PMID- 29822332
TI  - The Medical Profession and the Bill.

PMID- 29822331
TI  - The German System.

PMID- 29822333
TI  - Mr. West's Address.

PMID- 29822334
TI  - The Comparative Function of Each Kidney.

PMID- 29822335
TI  - Institutional Notes and News.

PMID- 29822336
TI  - An Ethical Point.

PMID- 29822337
TI  - Pneumococcal Septicaemia Starting from a Uterine Focus.

PMID- 29822338
TI  - The British Medical Association at Birmingham.

PMID- 29822339
TI  - New Appliances and Things Medical.

PMID- 29822341
TI  - Home and Foreign Spas : IX. Llangammarch Wells.

PMID- 29822340
TI  - The British Pharmaceutical Conference.

PMID- 29822342
TI  - Institutional Notes and News.

PMID- 29822343
TI  - The Hospital World.

PMID- 29822345
TI  - Injection of the Broad Ligaments for Prolapsus Uteri.

PMID- 29822344
TI  - The Voluntary Hospitals and the Insurance Bill.

PMID- 29822346
TI  - The Week's Work.

PMID- 29822347
TI  - Hospital Deputation to the Chancellor of the Exchequer.

PMID- 29822348
TI  - Eminent Chairmen Series : IX. Lieut.-Colonel E. M. Bruce Vaughan, V.D.

PMID- 29822349
TI  - Annotations.

PMID- 29822350
TI  - Maternity and the Teaching Profession.

PMID- 29822351
TI  - The Medical and Social Aspects of Consumption.

PMID- 29822352
TI  - Progress of the National Insurance Bill.

PMID- 29822353
TI  - Medical Opinion and Movement.

PMID- 29822354
TI  - The National Insurance Bill.

PMID- 29822356
TI  - The Royal Sanitary Institute at Belfast.

PMID- 29822355
TI  - The Views of Hospital Secretaries.

PMID- 29822357
TI  - The Hospital World.

PMID- 29822358
TI  - Progress of the National Insurance Bill.

PMID- 29822359
TI  - The Albany Hospital and the Blaauwkrantz Accident.

PMID- 29822360
TI  - Orientirung.

PMID- 29822361
TI  - Medical Opinion and Movement.

PMID- 29822362
TI  - A Mediaeval Hospital.

PMID- 29822363
TI  - The Week's Work.

PMID- 29822364
TI  - The Practice Market.-V : The Purchaser's Point of View.

PMID- 29822365
TI  - The Expansion of the Kensington Hospital.

PMID- 29822366
TI  - The Problems of Private Practice : Hospitals: From the Point of View of the G. P.

PMID- 29822367
TI  - Water Softening.

PMID- 29822368
TI  - Severe Pyodermia from Bromides.

PMID- 29822369
TI  - The Views of Hospital Secretaries.

PMID- 29822370
TI  - Annotations.

PMID- 29822372
TI  - Institutional Notes and News.

PMID- 29822371
TI  - The Standard of Preliminary Education.

PMID- 29822373
TI  - Home and Foreign Spas.

PMID- 29822374
TI  - Hospitals and State Aid: Conditions under Which Government Aid Is Given to
      Hospitals.

PMID- 29822375
TI  - Rectal Incontinence and Its Treatment.

PMID- 29822376
TI  - Medicine and the Liberal Spirit.

PMID- 29822377
TI  - Hospitals and the Insurance Bill.

PMID- 29822379
TI  - Provident Dispensaries and the Bill.

PMID- 29822378
TI  - The Medical Profession and the Insurance Bill.

PMID- 29822380
TI  - Institutional Notes and News.

PMID- 29822381
TI  - Home and Foreign Spas : VIII. Woodhall Spa.

PMID- 29822383
TI  - Practitioners, Friendly Societies, and the Bill.

PMID- 29822382
TI  - The Growth of the West Ham Hospital.

PMID- 29822385
TI  - Parliament and Publications.

PMID- 29822384
TI  - The Committee Stage of the National Insurance Bill.

PMID- 29822386
TI  - The Hospital Conference in Cork.

PMID- 29822387
TI  - The Week's Work.

PMID- 29822388
TI  - The Manchester Meeting.

PMID- 29822389
TI  - Some Medical Aphorisms and Experiences.

PMID- 29822390
TI  - B. M. A. v. L. C. C.

PMID- 29822391
TI  - The German System.

PMID- 29822392
TI  - Annotations.

PMID- 29822393
TI  - Medical Opinion and Movement.

PMID- 29822394
TI  - The Views of Hospital Secretaries.

PMID- 29822395
TI  - Meeting of the Central Hospital Council.

PMID- 29822396
TI  - Parliament and Publications.

PMID- 29822397
TI  - The National Insurance Bill.

PMID- 29822398
TI  - The Important Role of the Larynx in General Anaesthesia.

PMID- 29822399
TI  - Hospitals and State Aid.-II: Conditions under which Government Aid is Given to
      Hospitals.

PMID- 29822400
TI  - Midland Hospitals on the National Insurance Bill.

PMID- 29822401
TI  - News and Events of the Week.

PMID- 29822402
TI  - The Coronation.

PMID- 29822403
TI  - Hospitals and the Problem of Reform.

PMID- 29822404
TI  - Bruits over Thoracic Aneurysm.

PMID- 29822406
TI  - Annotations.

PMID- 29822405
TI  - Buildings Contemplated and in Progress.

PMID- 29822407
TI  - Peptonised Iodine in Tuberculosis.

PMID- 29822409
TI  - Institutional Notes and News.

PMID- 29822408
TI  - The German System.

PMID- 29822410
TI  - The Week's Work.

PMID- 29822411
TI  - The Hospital World.

PMID- 29822413
TI  - The Practice Market.-VI : Further Considerations for the Purchaser.

PMID- 29822412
TI  - Coronation Honours.

PMID- 29822415
TI  - Home and Foreign Spas.

PMID- 29822414
TI  - Hospitals and a Paid Staff.

PMID- 29822417
TI  - Hospital Doors.

PMID- 29822416
TI  - The New Radium Institute.

PMID- 29822418
TI  - Medical Opinion and Movement.

PMID- 29822419
TI  - Grave Situation in the Liverpool District.

PMID- 29822420
TI  - Annotations.

PMID- 29822421
TI  - The Week's Work.

PMID- 29822422
TI  - Alleged Infective Dangers of the Communion Cup.

PMID- 29822423
TI  - Institutional Notes and News.

PMID- 29822424
TI  - The Insurance Bill and Charitable Institutions.

PMID- 29822425
TI  - Thirty Years of Provident Dispensary Work.

PMID- 29822426
TI  - Parliament and Publications.

PMID- 29822427
TI  - Ptomaine Poisoning.-I.

PMID- 29822428
TI  - The New Laboratories at the London School of Tropical Medicine.

PMID- 29822429
TI  - West Riding Hospitals and the Insurance Bill.

PMID- 29822430
TI  - The Hospital World.

PMID- 29822432
TI  - News and Events of the Week.

PMID- 29822431
TI  - The National Insurance Bill.

PMID- 29822434
TI  - Annotations.

PMID- 29822433
TI  - Some Selected Skin Cases.

PMID- 29822435
TI  - The Saturday Fund and the Insurance Bill.

PMID- 29822436
TI  - Vaccination Officers' Grievances.

PMID- 29822438
TI  - Mr. Conrad W. Thies.

PMID- 29822437
TI  - How We Adopted the Uniform System of Accounts.

PMID- 29822440
TI  - Twenty-Three Years at Bethlem Hospital.

PMID- 29822439
TI  - Queen's Hospital, Birmingham.

PMID- 29822441
TI  - Institutional Notes and News.

PMID- 29822442
TI  - Medical Opinion and Movement.

PMID- 29822443
TI  - The Hospital World.

PMID- 29822444
TI  - The Week's Work.

PMID- 29822445
TI  - Progress of the National Insurance Bill.

PMID- 29822446
TI  - Wake up! Voluntary Hospital Managers.

PMID- 29822448
TI  - How Ships' Surgeons Are Appointed.

PMID- 29822447
TI  - Insurance Bill Developments.

PMID- 29822449
TI  - London Post-Graduate Institutions.

PMID- 29822450
TI  - The English Conjoint Course.

PMID- 29822451
TI  - The Study of Tropical Medicine.

PMID- 29822452
TI  - The Study of Legal Medicine.

PMID- 29822453
TI  - Higher Diplomas.

PMID- 29822454
TI  - Oxford University.

PMID- 29822455
TI  - Qualification and Registration.

PMID- 29822456
TI  - The London University Course.

PMID- 29822457
TI  - Facts and Factors in Medicine.

PMID- 29822458
TI  - The Study of Morbid Anatomy.

PMID- 29822459
TI  - How to Obtain a Degree or Diploma in Public Health.

PMID- 29822460
TI  - The Cambridge University Course.

PMID- 29822461
TI  - Opportunities for Graduate Study in Special Hospitals.

PMID- 29822462
TI  - The Study of Medicine.

PMID- 29822463
TI  - The Colonial Medical Service.

PMID- 29822464
TI  - Graduate Study in Scotland and Ireland.

PMID- 29822465
TI  - How to Choose and Use a Microscope.

PMID- 29822466
TI  - The Medical Schools of the United Kingdom.

PMID- 29822467
TI  - The Public Services.

PMID- 29822468
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29822469
TI  - The Insurance Bill.

PMID- 29822470
TI  - The Sandow Case.

PMID- 29822471
TI  - National Insurance Bill-Second Reading.

PMID- 29822473
TI  - The Problems of Private Practice.

PMID- 29822472
TI  - Institutional Notes and News.

PMID- 29822474
TI  - The Paddington Green Hospital for Children.

PMID- 29822475
TI  - Home and Foreign Spas : VI. Llandrindod Wells.

PMID- 29822476
TI  - Midwives and the National Insurance Bill.

PMID- 29822477
TI  - Annotations.

PMID- 29822478
TI  - The Hospital World.

PMID- 29822479
TI  - Appendicitis and Pseudo-Appendicitis in Certain Infectious Diseases.-I.

PMID- 29822481
TI  - Death from Gall-Stone Colic.

PMID- 29822480
TI  - The Cancer Hospital, Fulham.

PMID- 29822482
TI  - Electro-Therapy and Radiography.

PMID- 29822483
TI  - Lodgings for Women.

PMID- 29822484
TI  - Medical Opinion and Movement.

PMID- 29822485
TI  - The Homoeopathic Hospital New Nurses' Home.

PMID- 29822486
TI  - Parliament and Publications.

PMID- 29822487
TI  - News and Events of the Week.

PMID- 29822488
TI  - The Insurance Bill.

PMID- 29822490
TI  - The Week's Work.

PMID- 29822489
TI  - How It Will Affect the Worker.

PMID- 29822491
TI  - Leicester Infirmary.

PMID- 29822492
TI  - The Hospital World.

PMID- 29822493
TI  - Some Spinal Cord Lesions.-V.

PMID- 29822494
TI  - Institutional Outdoor Work and Administration.

PMID- 29822495
TI  - The Territorial Soldier and the Care of the Feet.

PMID- 29822497
TI  - Royal Hants County Hospital, Winchester-Nurses' Home.

PMID- 29822496
TI  - Ptomaine Poisoning.-II.

PMID- 29822498
TI  - Annotations.

PMID- 29822499
TI  - The Asylums Board Report.

PMID- 29822501
TI  - Allosan in the Treatment of Gonorrhoea.

PMID- 29822500
TI  - The Emigration of Young Women.

PMID- 29822502
TI  - The Care of Hospital Floors.

PMID- 29822503
TI  - The Week's Work.

PMID- 29822504
TI  - Workmen's Compensation Cases.

PMID- 29822505
TI  - The Practice Market.-VIII : The Investigation of a Medical Practice.

PMID- 29822507
TI  - Occipito-Posterior Presentations.

PMID- 29822506
TI  - Medical Opinion and Movement.

PMID- 29822508
TI  - The Hospital World.

PMID- 29822509
TI  - Spiritual Healing.

PMID- 29822510
TI  - Acid-Resisting Mackintosh.

PMID- 29822511
TI  - Validol in Dipsomania.

PMID- 29822512
TI  - Institutional Outdoor Work and Administration.

PMID- 29822514
TI  - "The Hospital" at One Penny.

PMID- 29822513
TI  - Workmen's Compensation.

PMID- 29822515
TI  - The Ward Wall.

PMID- 29822516
TI  - On the History of Syphilis in Europe.

PMID- 29822517
TI  - Annotations.

PMID- 29822518
TI  - The Nutritive Value of "Standard" Bread.

PMID- 29822520
TI  - Medical Opinion and Movement.

PMID- 29822519
TI  - Queer Definitions in Hospital Diet.

PMID- 29822521
TI  - King Edward VII.'s Hospital, Cardiff.

PMID- 29822523
TI  - A Claim in Respect of Tetanus.

PMID- 29822522
TI  - The Dietetics of the Channel Swim.

PMID- 29822524
TI  - Progress of the National Insurance Bill.

PMID- 29822525
TI  - Some Spinal Cord Lesions: VII. Hereditary Ataxy (Friedreich's Disease).

PMID- 29822527
TI  - Home for Epileptic Boy.

PMID- 29822526
TI  - Cystoscopy.

PMID- 29822528
TI  - A Question for Hospital Treasurers.

PMID- 29822529
TI  - Some Trade Unionists on Doctors.

PMID- 29822530
TI  - The Papers and Discussions.

PMID- 29822531
TI  - Post-Graduate Examinations.

PMID- 29822533
TI  - Annotations.

PMID- 29822532
TI  - Splanchnoptosis (Enteroptosis).

PMID- 29822534
TI  - The Miller General Hospital, Greenwich.

PMID- 29822535
TI  - The Hospital World.

PMID- 29822536
TI  - Rival Systems of Ward Ventilation.

PMID- 29822537
TI  - Medical Opinion and Movement.

PMID- 29822538
TI  - The Royal Navy Medical Service.

PMID- 29822539
TI  - The Navy Medical Service.

PMID- 29822540
TI  - Acid Resisting Mackintoshes.

PMID- 29822541
TI  - The Week's Work.

PMID- 29822542
TI  - Mercurial Poisoning Amongst Hatters.

PMID- 29822544
TI  - Impressions of the British Association Meeting.

PMID- 29822543
TI  - Suggestions for the Treatment of Insomnia.

PMID- 29822545
TI  - Queer Definitions in Hospital Diet.

PMID- 29822546
TI  - Medical Opinion and Movement.

PMID- 29822548
TI  - Charity and the Industrial Classes.

PMID- 29822547
TI  - Hospitals and the Insurance Bill.

PMID- 29822549
TI  - News and Events of the Week.

PMID- 29822550
TI  - Imperial Health Problems.

PMID- 29822551
TI  - Parliament and Publications.

PMID- 29822552
TI  - The Progress of the Metropolitan Hospital.

PMID- 29822553
TI  - Some Queer Definitions in Hospital Diet.

PMID- 29822554
TI  - The Physiological Value of Beer.

PMID- 29822555
TI  - Obstetric and Gynaecological Studies in Berlin.

PMID- 29822556
TI  - The Week's Work.

PMID- 29822557
TI  - A Model of Judicious Advertising.

PMID- 29822558
TI  - Acute Mastoiditis.

PMID- 29822559
TI  - Hospital Progress Abroad.

PMID- 29822560
TI  - Annotations.

PMID- 29822561
TI  - Some Gastric Symptoms and Gastric Diseases.

PMID- 29822562
TI  - Some Queer Definitions in Hospital Diet.

PMID- 29822563
TI  - Insuring Patients against Accidents.

PMID- 29822564
TI  - Hints for Hospital Stewards.

PMID- 29822565
TI  - Acid-Resisting Mackintosh.

PMID- 29822566
TI  - Institutional Outdoor Work and Administration.

PMID- 29822567
TI  - Medical Opinion and Movement.

PMID- 29822568
TI  - Concentrated Meat Foods.

PMID- 29822569
TI  - Medical Revolution.

PMID- 29822570
TI  - The Best Illuminant for Small Hospitals.

PMID- 29822571
TI  - Winchester Nurses' Home.

PMID- 29822572
TI  - Some Spinal Cord Lesions.-VI: Compression Paraplegia.

PMID- 29822573
TI  - The Royal Navy Medical Service.

PMID- 29822574
TI  - Annotations.

PMID- 29822575
TI  - American Work in Eugenics.

PMID- 29822576
TI  - The Hospital World.

PMID- 29822577
TI  - Local Government Medical Officers and the Central Authorities.

PMID- 29822579
TI  - Sewage Disposal.

PMID- 29822578
TI  - The Week's Work.

PMID- 29822580
TI  - Eminent Chairmen Series : X. Mr. Alderman Joseph Jones, Late Chairman of the
      Wolverhampton and Midland Counties' Eye Infirmary.

PMID- 29822581
TI  - Hospital Concerts and Yorkshire Wakes.

PMID- 29822582
TI  - The "Complaints Book" at the South Infirmary, Cork.

PMID- 29822583
TI  - The Silly Season Again.

PMID- 29822584
TI  - Ptomaine Poisoning-III.

PMID- 29822585
TI  - The Ideal Car for General Practice.

PMID- 29822586
TI  - The Effects upon the Royal Infirmary, Bradford.

PMID- 29822587
TI  - Hospital Benefit and the Insurance Act.

PMID- 29822588
TI  - Insurance Provision for Hospital Workers.

PMID- 29822589
TI  - Maternity and Mothering: Nervous Vomiting in Childhood.

PMID- 29822590
TI  - On Megaloblastic Degeneration.

PMID- 29822591
TI  - Legal Notes for Institutional Workers.

PMID- 29822592
TI  - Hospital and Institutional News.

PMID- 29822593
TI  - The Protection of the Successful.

PMID- 29822594
TI  - Our Bureau of Information.

PMID- 29822595
TI  - Reports on the Hospitals of the United Kingdom: LX. The Hull Royal Infirmary.

PMID- 29822597
TI  - The Solution to the Waste Problem.

PMID- 29822596
TI  - A Metropolitan Secretary's Optimism.

PMID- 29822598
TI  - Apparatus for Light and Current from the Main.

PMID- 29822599
TI  - The Institutional Worker.

PMID- 29822600
TI  - Country Clergy and Secret Remedies.

PMID- 29822601
TI  - Hospital Work in East Anglia.

PMID- 29822602
TI  - The Medical Training of Missionaries.

PMID- 29822603
TI  - An Improved Form of Shelter for Use in the Open-Air Treatment of Phthisis.

PMID- 29822604
TI  - The Surgical Treatment of Stone: A Review of Its Practice during the Last Sixty
      Years.-I.

PMID- 29822606
TI  - The Rheumatic Diathesis.

PMID- 29822607
TI  - Hospital and Institutional News.

PMID- 29822605
TI  - Reply to "Thirty Years a Hospital Superintendent."

PMID- 29822608
TI  - Practical Points.

PMID- 29822609
TI  - Medical Opinion and Movement.

PMID- 29822610
TI  - Relaxation and Hobbies: Applied Photography.

PMID- 29822611
TI  - The Colour of the Hair.

PMID- 29822612
TI  - The Hon. Sydney Holland on Differences of Opinion.

PMID- 29822613
TI  - The Royal Army Medical Corps Section.

PMID- 29822614
TI  - The Institutional Worker.

PMID- 29822615
TI  - Hospitals under the National Insurance Act.

PMID- 29822617
TI  - The Male Staff of Hospitals.

PMID- 29822616
TI  - Voluntary Hospitals and National Insurance.

PMID- 29822618
TI  - Hospital Clerks: Their Duties and Responsibilities.-II.

PMID- 29822619
TI  - Institutional Housekeeping.

PMID- 29822620
TI  - Our Bureau of Information.

PMID- 29822621
TI  - Maternity and Mothering: An American System of Infant Feeding.

PMID- 29822622
TI  - The Making of a Modern Hospital : The Ward Itself.

PMID- 29822623
TI  - Hospital and Institutional News.

PMID- 29822624
TI  - Our Bureau of Information.

PMID- 29822625
TI  - The Patients' Christmas Day.

PMID- 29822626
TI  - Reports on the Hospitals of the United Kingdom: LIX. The Victoria Hospital for
      Sick Children, Hull.

PMID- 29822627
TI  - The Position and Prospects of Hospitals in 1912.

PMID- 29822628
TI  - The Value of Weighing Patients.

PMID- 29822630
TI  - Legal Notes for Institutional Workers.

PMID- 29822629
TI  - Apparatus for Cautery and Light.

PMID- 29822632
TI  - The Metropolitan Hospital Sunday Fund.

PMID- 29822631
TI  - Paying Patients at Cardiff Infirmary: How the New System Was Instituted.

PMID- 29822634
TI  - Phthisis Simulated by Oidium Lesions in Ceylon.

PMID- 29822633
TI  - Great Gifts during Life and after Death.

PMID- 29822635
TI  - The Institutional Worker.

PMID- 29822636
TI  - Metropolitan Hospital Sunday Fund Procedure and Its Amendment.

PMID- 29822637
TI  - The Government and the Voluntary Hospitals.

PMID- 29822638
TI  - The Brewers' Exhibition.

PMID- 29822639
TI  - The Jewish Hospital, Manchester.

PMID- 29822640
TI  - Disease, the Voluntary Hospitals, and Mr. Lloyd George.

PMID- 29822641
TI  - The School Clinic: II. The General Practitioner's Point of View.

PMID- 29822642
TI  - The Institutional Worker.

PMID- 29822644
TI  - Institutional Housekeeping.

PMID- 29822643
TI  - Our Bureau of Information.

PMID- 29822645
TI  - Legal Notes for Institutional Workers.

PMID- 29822646
TI  - The League of Mercy.

PMID- 29822647
TI  - Unoccupied Buildings and Vacant Beds.

PMID- 29822648
TI  - Maternity and Mothering: II. The Care of Children's Teeth.

PMID- 29822649
TI  - The Making of a Modern Hospital: IV. The Departments of the Modern Hospital.

PMID- 29822650
TI  - Sanatoria for the People: What They Can and Cannot Accomplish.

PMID- 29822651
TI  - Science and the Soul.

PMID- 29822652
TI  - The Making of the Modern Practitioner: The Results of Gastric Operations.

PMID- 29822653
TI  - Dispensers and the Insurance Bill.

PMID- 29822654
TI  - Hospital and Institutional News.

PMID- 29822655
TI  - Institutional Outdoor Work and Administration.

PMID- 29822656
TI  - The Scandal of Out-Patients: A Suggestion.

PMID- 29822657
TI  - Maternity and Mothering: The Men and Women of To-morrow.

PMID- 29822659
TI  - The Institutional Worker.

PMID- 29822658
TI  - The Poor Law Infirmary.

PMID- 29822660
TI  - Good Accounting and the Uniform System.

PMID- 29822661
TI  - The British Hospitals Association.

PMID- 29822662
TI  - A New Sub-Department of Medicine.

PMID- 29822663
TI  - The Passing of a Great Teacher.

PMID- 29822665
TI  - The Making of a Modern Hospital: II. Classification of Modern Hospitals.

PMID- 29822664
TI  - Scandal of Out-Patients.

PMID- 29822667
TI  - Hospital and Institutional News.

PMID- 29822666
TI  - Medical Opinion and Movement.

PMID- 29822669
TI  - What Will the Chancellor of the Exchequer Do? The Two Alternatives.

PMID- 29822668
TI  - A Correction.

PMID- 29822670
TI  - Co-Operation Invited.

PMID- 29822671
TI  - The School Clinic: I. Why School Clinics are Necessary.

PMID- 29822672
TI  - Legal Notes for Institutional Workers.

PMID- 29822673
TI  - Hospital Officers' Visit to Southport.

PMID- 29822674
TI  - Hospital Architecture and Construction.

PMID- 29822675
TI  - The Insane and the Law: How Organised Treatment of the Insane Began.

PMID- 29822676
TI  - Institutional Life at Its Best.

PMID- 29822677
TI  - The Scandal of Out-Patients.

PMID- 29822678
TI  - The London Medical Exhibition.

PMID- 29822679
TI  - Byways of Medical Relief.

PMID- 29822680
TI  - Co-Operation and Inter-Communication.

PMID- 29822682
TI  - Twenty-Five Years' Institutional Progress.

PMID- 29822681
TI  - The Re-Opening of the School of Pharmacy.

PMID- 29822683
TI  - Reunion of Charing Cross Hospital Students.

PMID- 29822684
TI  - The British Hospitals Association.

PMID- 29822685
TI  - The Value of Sanatoriums under the Insurance Bill.

PMID- 29822686
TI  - New Appliances.

PMID- 29822687
TI  - Practical Points.

PMID- 29822688
TI  - Notes on News from the Institutional World.

PMID- 29822689
TI  - The Making of a Modern Hospital: Introductory.

PMID- 29822690
TI  - Housekeeping from the Higher Standpoint.

PMID- 29822692
TI  - The League of Mercy.

PMID- 29822691
TI  - Some Conditions Resembling Hip-Joint Disease in Children.

PMID- 29822693
TI  - Hospital and Institutional News.

PMID- 29822694
TI  - Dispensers and the Insurance Bill.

PMID- 29822696
TI  - Research and Remedies.

PMID- 29822695
TI  - News and Events.

PMID- 29822697
TI  - The Defective and Dependent: Introductory.

PMID- 29822699
TI  - Institutional Housekeeping.

PMID- 29822698
TI  - Reports on the Hospitals of the United Kingdom: LVI. Boston Hospital,
      Lincolnshire.

PMID- 29822700
TI  - Maternity and Mothering: The Care of Children's Teeth.-III.

PMID- 29822701
TI  - Certification and the Responsibilities Involved.

PMID- 29822702
TI  - The Death-Rate from Phthisis.

PMID- 29822703
TI  - The Institutional Worker.

PMID- 29822704
TI  - Our Bureau of Information.

PMID- 29822705
TI  - Mental Hospital Matters.

PMID- 29822706
TI  - Home Treatment.

PMID- 29822707
TI  - The Duty of the Physician in Cases of Hopeless Pain.

PMID- 29822709
TI  - Practical Points.

PMID- 29822708
TI  - Medical Opinion and Movement.

PMID- 29822711
TI  - Hospital and Institutional News.

PMID- 29822710
TI  - The Making of a Modern Hospital: IV. The Departments of a Modern Hospital.

PMID- 29822712
TI  - The Scandal of Out-Patients.

PMID- 29822713
TI  - Maternity and Mothering: The Care of Children's Teeth.

PMID- 29822715
TI  - Legal Notes for Institutional Workers.

PMID- 29822714
TI  - Hospital Architecture and Construction: Malvern Hospital.

PMID- 29822716
TI  - Institutional Housekeeping.

PMID- 29822718
TI  - Shall the Florence Nightingale Memorial Fail?

PMID- 29822717
TI  - The Insurance Bill and Voluntary Hospitals.

PMID- 29822719
TI  - Byways of Medical Relief.

PMID- 29822720
TI  - What the Destruction of the Voluntary Hospitals May Cost the State.

PMID- 29822722
TI  - Practical Points.

PMID- 29822721
TI  - An Appreciation.

PMID- 29822723
TI  - The Capital Cost of London and Provincial Hospitals.

PMID- 29822724
TI  - Medical Legal Points.

PMID- 29822725
TI  - Hospitals and the Insurance of Patients.

PMID- 29822726
TI  - The Making of a Modern Hospital: III. Modern Hospital Systems.

PMID- 29822727
TI  - The Institutional Worker.

PMID- 29822728
TI  - The National Insurance Bill.

PMID- 29822729
TI  - Hospitals and Street Noises.

PMID- 29822730
TI  - Mental Hospital Matters.

PMID- 29822731
TI  - The Royal Naval Medical Service.

PMID- 29822733
TI  - The General Medical Council and Voluntary Hospitals.

PMID- 29822732
TI  - Pharmaceutical Disorganisation: Its Causes and a Suggested Remedy.

PMID- 29822734
TI  - The Institutional Worker.

PMID- 29822735
TI  - A Radical Newspaper and British Workmen's Interests.

PMID- 29822737
TI  - Our Bureau of Information.

PMID- 29822736
TI  - The Making of a Modern Hospital : VI. The Ward Unit.

PMID- 29822738
TI  - The Problem of the Very Sick Citizen.

PMID- 29822739
TI  - Electricity in Modern Medicine: II. Sources of Electricity.

PMID- 29822740
TI  - Legal Aid Societies.

PMID- 29822742
TI  - The British Hospitals Association and the National Insurance Bill: A Bill
      Injurious to the Voluntary Hospitals and Grievously Cruel to British Workmen.

PMID- 29822741
TI  - Hospital and Institutional News.

PMID- 29822743
TI  - The School Clinic: The Teachers' Point of View.

PMID- 29822744
TI  - Institutional Housekeeping.

PMID- 29822746
TI  - The Secretary's Role at a Board Meeting.

PMID- 29822745
TI  - Natural Selection in Man.

PMID- 29822747
TI  - The London Hospital Chairman's View.

PMID- 29822749
TI  - The National Insurance Bill and Hospital Benefit.

PMID- 29822748
TI  - The Hospital Crisis: The Dangers of Unbelief.

PMID- 29822750
TI  - Hospital and Institutional News.

PMID- 29822751
TI  - The Outlook for Voluntary Hospitals.

PMID- 29822753
TI  - The Institutional Worker.

PMID- 29822752
TI  - The Truth about Sanatoria: Three Essential Points to Success.

PMID- 29822754
TI  - The Patients' Christmas Week.

PMID- 29822755
TI  - Institutional Housekeeping.

PMID- 29822756
TI  - Hospital Clerks: Their Duties and Responsibilities.

PMID- 29822757
TI  - Medical Opinion and Movement.

PMID- 29822758
TI  - By the House Governor of a Northern Hospital.

PMID- 29822759
TI  - The Fever Hospitals of the Metropolitan Asylums Board.-II.

PMID- 29822760
TI  - The School Clinic : VI. The Managers' Point of View.

PMID- 29822761
TI  - Borough Hospital, Waddon.

PMID- 29822762
TI  - Our Bureau of Information.

PMID- 29822763
TI  - The National Insurance Medical Association.

PMID- 29822764
TI  - The Defective and Dependent : IV. Education of the Mentally Defective.

PMID- 29822765
TI  - Byways of Medical Relief.

PMID- 29822766
TI  - A Scottish Treasurer's View of the Outlook.

PMID- 29822768
TI  - Legal Notes for Institutional Workers.

PMID- 29822767
TI  - The Voluntary Hospitals and National Insurance.

PMID- 29822769
TI  - Our Bureau of Information.

PMID- 29822770
TI  - The Making of a Modern Hospital: V. Where Should the Hospital be Placed?

PMID- 29822771
TI  - Children's Hospital, Paddington Green.

PMID- 29822772
TI  - Hospital Managers and Probationer's Contracts.

PMID- 29822773
TI  - Institutional Housekeeping.

PMID- 29822774
TI  - The Institutional Worker.

PMID- 29822775
TI  - Dispensers and the Insurance Bill.

PMID- 29822776
TI  - The British Hospitals Association in Glasgow.

PMID- 29822777
TI  - Reports on the Hospitals of the United Kingdom: LVII. Johnson Hospital, Spalding.

PMID- 29822779
TI  - Maternity and Mothering: Rest and Exercise after Confinement-I.

PMID- 29822778
TI  - Hospital and Institutional News.

PMID- 29822781
TI  - Medical Legal Points: II. Death from a Medico-Legal Aspect.

PMID- 29822780
TI  - The Problems of Modern Psychiatry-II.

PMID- 29822782
TI  - The Insurance Bill and the Hospitals.

PMID- 29822783
TI  - The Defective and Dependent: II. The Ameliorative Treatment of Defectives.

PMID- 29822785
TI  - By-Ways of Medical Relief.

PMID- 29822784
TI  - The New Boarding-Out Order.

PMID- 29822786
TI  - Thirty-Two Years of Public Health.

PMID- 29822787
TI  - Hospital Architecture and Construction.

PMID- 29822788
TI  - Our Hospitals and Christmas Day.

PMID- 29822789
TI  - Our Bureau of Information.

PMID- 29822791
TI  - The League of Mercy.

PMID- 29822790
TI  - Hospital and Institutional News.

PMID- 29822793
TI  - Milk and Tuberculosis.

PMID- 29822792
TI  - The Practitioner's Relaxations and Hobbies.

PMID- 29822794
TI  - The Washing of New-Born Infants.

PMID- 29822795
TI  - A Phthisical Bureau for London.

PMID- 29822796
TI  - The Queen's Hall Meeting: The Real Significance of the Demonstration.

PMID- 29822797
TI  - A Case of Nystagmus.

PMID- 29822798
TI  - A Swiss Hospital for Paying Patients.

PMID- 29822799
TI  - The Institutional Worker.

PMID- 29822801
TI  - The King's Hospital Fund for London and St. George's Hospital.

PMID- 29822800
TI  - A Foreword to Workers for the Sick!

PMID- 29822802
TI  - Welsh Hospital Managers.

PMID- 29822803
TI  - Compensation for a Broken Back.

PMID- 29822805
TI  - The Institutional Worker.

PMID- 29822804
TI  - The Colour of the Hair.

PMID- 29822807
TI  - The Making of the Modern Practitioner: Degrees and Diplomas-I.

PMID- 29822806
TI  - The Male Staff of Hospitals.

PMID- 29822808
TI  - Legal Notes for Institutional Workers.

PMID- 29822810
TI  - The Cottage Hospital in Fiction.

PMID- 29822809
TI  - The Surgical Treatment of Stone: A Review of Its Practice during the Last Sixty
      Years.-II.

PMID- 29822812
TI  - Anatomy in the Training of the Medical Man.

PMID- 29822811
TI  - The Grouping of Subjects in Home Science.

PMID- 29822814
TI  - Hospital and Institutional News.

PMID- 29822813
TI  - Muzzling the School Doctor.

PMID- 29822816
TI  - Preventible Social Ills: The Spirit of Pauperism.

PMID- 29822815
TI  - Openings for the Sons of Medical Men.

PMID- 29822817
TI  - Reports on the Hospitals of the United Kingdom: LXI. York County Hospital.

PMID- 29822818
TI  - Maternity and Mothering: Some Problems of Birth.

PMID- 29822819
TI  - Schools for Tubercular Children.

PMID- 29822820
TI  - Our Bureau of Information.

PMID- 29822821
TI  - Current from the Main.

PMID- 29822823
TI  - The Additions to Radcliffe Infirmary, Oxford.

PMID- 29822822
TI  - Infirmary Patients Sleeping on the Floor.

PMID- 29822824
TI  - Practical Points.

PMID- 29822825
TI  - The Value of Management in the Workroom.

PMID- 29822827
TI  - Hospital and Institutional News.

PMID- 29822826
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29822828
TI  - Research and Remedies.

PMID- 29822829
TI  - The Institutional Worker.

PMID- 29822830
TI  - Little Homes for Ailing Children.

PMID- 29822831
TI  - Surgery's Debt to the Late Sir Henry Butlin.

PMID- 29822832
TI  - The Evolution of a County Hospital.

PMID- 29822833
TI  - Our Bureau of Information.

PMID- 29822834
TI  - A Foreigner's View on English Cottage Hospitals.

PMID- 29822835
TI  - The National Insurance Act and the Voluntary Hospitals: Conference, Opinions,
      Policy and Security.

PMID- 29822836
TI  - The Stake of Professional Reputation.

PMID- 29822837
TI  - The Hospital Pay of Shorthand-Typists.

PMID- 29822838
TI  - Legal Notes for Institutional Workers.

PMID- 29822839
TI  - The Surgical Treatment of Stone: A Review of Its Practice during the Last Sixty
      Years.-III.

PMID- 29822840
TI  - The Vomiting of Pregnancy.

PMID- 29822841
TI  - Byways of Medical Relief.

PMID- 29822843
TI  - Hospital and Institutional News.

PMID- 29822842
TI  - A Good Book on Massage.

PMID- 29822844
TI  - A New Electrical Instrument: The German Invention for Utilising High-frequency
      Currents.

PMID- 29822845
TI  - An Original Open-Air Shelter for a Number of Patients Simultaneously.

PMID- 29822846
TI  - The Institutional Worker.

PMID- 29822847
TI  - The Voluntary Hospitals and an Amending Act.

PMID- 29822848
TI  - The School Clinic: Diseases of the Eye.

PMID- 29822849
TI  - The Late Mr. Arthur Reade.

PMID- 29822850
TI  - The Making of a Modern Hospital.

PMID- 29822851
TI  - The Defective and Dependent : V. The Education of the Blind.

PMID- 29822852
TI  - Our Bureau of Information.

PMID- 29822853
TI  - A Case of Milroy's Disease: With Notes on Trophoedema.

PMID- 29822854
TI  - Institutional Housekeeping.

PMID- 29822856
TI  - Research and Remedies.

PMID- 29822855
TI  - Reports on the Hospitals of the United Kingdom: LXII. The Royal Hospital,
      Sheffield.

PMID- 29822858
TI  - The Position of St. Bartholomew's Hospital.

PMID- 29822857
TI  - The German System. How the New Insurance Regulations Affect the German Hospitals.

PMID- 29822860
TI  - The Making of the Modern Practitioner: Degrees and Diplomas.-II.

PMID- 29822859
TI  - Hospital and Institutional News.

PMID- 29822862
TI  - The Institutional Worker.

PMID- 29822861
TI  - Post-Anaesthetic Broncho-Pneumonia: I. Its Causation and Prevention.

PMID- 29822863
TI  - The Additions to Radcliffe Infirmary, Oxford.

PMID- 29822864
TI  - The Syngros Hospital, Athens.

PMID- 29822865
TI  - Recent Progress in Hospital Construction.

PMID- 29822866
TI  - Byways of Medical Relief.

PMID- 29822867
TI  - A New Building Material.-Plate Porcelain.

PMID- 29822868
TI  - Institutional Housekeeping.

PMID- 29822869
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29822870
TI  - The Urgent Need for Dental Clinics.

PMID- 29822871
TI  - Some Red Cross Activities.

PMID- 29822873
TI  - Our Bureau of Information.

PMID- 29822872
TI  - A Hospital as a Cinema-Theatre.

PMID- 29822874
TI  - The Rev. G. E. Aspinall's Speech.

PMID- 29822875
TI  - Current from the Main.

PMID- 29822876
TI  - Muzzling the School Doctor.

PMID- 29822877
TI  - King Edward's Fund and the Evelina Hospital.

PMID- 29822878
TI  - A Hospital as a Cinema Theatre.

PMID- 29822879
TI  - Institutional Housekeeping.

PMID- 29822880
TI  - Local Anaesthesia with Cocaine and Adrenalin.

PMID- 29822881
TI  - Economical Sanatorium Construction.

PMID- 29822882
TI  - Plans for New British Hospitals: The Reforms Urgently Needed in Selecting Plans.

PMID- 29822883
TI  - Hospital and Institutional News.

PMID- 29822884
TI  - A Serious Misapprehension.

PMID- 29822885
TI  - A State Nursing Service.

PMID- 29822887
TI  - The Ideal Operating-Theatre.

PMID- 29822886
TI  - Who Should Have Charge of the Clinic?

PMID- 29822889
TI  - The Defective and Dependent : VI. The Education of the Deaf.

PMID- 29822888
TI  - Our Bureau of Information.

PMID- 29822890
TI  - Books on Swedish Treatment.

PMID- 29822891
TI  - Voluntary Hospital Employees and the National Insurance Act.

PMID- 29822892
TI  - Noise and Public Hospitals.

PMID- 29822893
TI  - Byways of Medical Relief.

PMID- 29822894
TI  - The Institutional Worker.

PMID- 29822896
TI  - The Making of the Modern Practitioner: The Internal Secretions in Therapeutics.

PMID- 29822895
TI  - Institutional Outdoor Work and Administration.

PMID- 29822897
TI  - Mental Hospital Matters.

PMID- 29822898
TI  - The School Clinic: IV. The Educative Value of the Clinic.

PMID- 29822900
TI  - Princess Louise at Paddington Children's Hospital.

PMID- 29822899
TI  - The Problems of Modern Psychiatry-III.

PMID- 29822901
TI  - Hospitals and Water Supply.

PMID- 29822902
TI  - Our Bureau of Information.

PMID- 29822903
TI  - The Royal Army Medical Corps Section.

PMID- 29822904
TI  - Faults in Institution Menus.

PMID- 29822905
TI  - Malvern Hospital.

PMID- 29822906
TI  - Have We a Responsible Government?

PMID- 29822907
TI  - Legal Notes for Institutional Workers.

PMID- 29822909
TI  - The Institutional Worker.

PMID- 29822908
TI  - Co-Education.

PMID- 29822910
TI  - Practical Points.

PMID- 29822911
TI  - Certificated Dispensers and the Insurance Bill.

PMID- 29822912
TI  - Hospital and Institutional News.

PMID- 29822913
TI  - Electricity in Modern Medicine: II. Sources of Electricity.

PMID- 29822914
TI  - Specimen Menus-Good and Bad.

PMID- 29822916
TI  - Maternity and Mothering: Rest and Exercise after Confinement.

PMID- 29822915
TI  - Hospitals and the Bill.

PMID- 29822917
TI  - Institutional Housekeeping.

PMID- 29822918
TI  - The National Insurance Bill: Our Editor Cross-examined by the King Editor of
      Weekly Journals.

PMID- 29822919
TI  - The Institutional Worker.

PMID- 29822920
TI  - Hospital Crests and Badges.

PMID- 29822921
TI  - Guy's Hospital "Scandals" and the Southwark Guardians.

PMID- 29822922
TI  - The Medical Profession in Relation to Inquests.

PMID- 29822923
TI  - Hospital and Institutional News.

PMID- 29822924
TI  - The Great Meeting of Voluntary Hospital Managers.

PMID- 29822925
TI  - Certificated Dispensers and the Insurance Bill.

PMID- 29822927
TI  - The Compulsory Notification of Pulmonary Tuberculosis.

PMID- 29822926
TI  - Reports on the Hospitals of the United Kingdom: Johnson Hospital, Spalding-II.

PMID- 29822928
TI  - Our Bureau of Information.

PMID- 29822929
TI  - Byways of Medical Relief.

PMID- 29822930
TI  - The Defective and Dependent: III. Mentally Defective Children.

PMID- 29822931
TI  - Death from a Medico-Legal Aspect.-III: I. Saponification of the Body.

PMID- 29822933
TI  - Legal Notes for Institutional Workers.

PMID- 29822932
TI  - Death from a Medico-Legal Aspect.-III: II. Death by Hanging.

PMID- 29822934
TI  - Practitioners, Consultants, and Fees.

PMID- 29822935
TI  - Maternity and Mothering: Nocturnal Incontinence.

PMID- 29822936
TI  - King Edward's Hospital Fund for London.

PMID- 29822937
TI  - The Making of the Modern Practitioner: A New Series of Medical Text Books.

PMID- 29822938
TI  - The Voluntary Hospitals and National Insurance.

PMID- 29822939
TI  - The Insurance Bill and the Hospitals.

PMID- 29822941
TI  - Research and Remedies.

PMID- 29822940
TI  - Our Bureau of Information.

PMID- 29822942
TI  - How to Amend the Insurance Bill.

PMID- 29822943
TI  - The Durbar Honours.

PMID- 29822944
TI  - The Brownhill Case at Birmingham.

PMID- 29822945
TI  - The Teaching of Pathology at St. Bartholomew's Hospital.

PMID- 29822946
TI  - Memorials to King Edward.

PMID- 29822947
TI  - Institutional Housekeeping.

PMID- 29822948
TI  - The Institutional Worker.

PMID- 29822949
TI  - Common-Sense Dietetics.

PMID- 29822950
TI  - Hospital and Institutional News.

PMID- 29822951
TI  - The Fever Hospitals of the Metropolitan Asylums Board.

PMID- 29822953
TI  - Thirty-Two Years of Public Health.

PMID- 29822952
TI  - Reports on the Hospitals of the United Kingdom: LVIII. The Alexandra Bromo-Iodine
      Hospital, Woodhall Spa.

PMID- 29822955
TI  - The King to His People.

PMID- 29822954
TI  - The Admission of In-Patients under National Insurance.

PMID- 29822957
TI  - The Health of School Children: Sir George Newman's Report.

PMID- 29822956
TI  - Institutional Housekeeping: Answers to Correspondents.

PMID- 29822958
TI  - Our Bureau of Information.

PMID- 29822959
TI  - The Axminster Cottage Hospital: A Transition to the New from the Old.

PMID- 29822960
TI  - The Hospital Officers Association.

PMID- 29822961
TI  - Electricity in Modern Medicine.

PMID- 29822962
TI  - The School Clinic: III. The Parents' Point of View.

PMID- 29822964
TI  - Legal Notes for Institutional Workers.

PMID- 29822963
TI  - The Problems of Modern Psychiatry.

PMID- 29822965
TI  - Institutional Housekeeping.

PMID- 29822966
TI  - Hospital Treatment for Insured Persons, and Mr. Lloyd George's Bill.

PMID- 29822967
TI  - Hospital Architecture and Construction: King Edward Memorial Hospital, Ealing.

PMID- 29822968
TI  - Hospital and Institutional News.

PMID- 29822970
TI  - Warneford, Leamington and South Warwickshire Hospital.

PMID- 29822969
TI  - Medico-Legal Section: Traumatic Neurasthenia.

PMID- 29822971
TI  - The Institutional Worker.

PMID- 29822972
TI  - The Memorial to Florence Nightingale.

PMID- 29822973
TI  - The Rebuilt Wing at Leeds Infirmary.

PMID- 29822975
TI  - Employees and the National Insurance Act: I. Some Preliminary Points of Interest.

PMID- 29822974
TI  - Certificated Dispensers and the Insurance Bill.

PMID- 29822976
TI  - Our Bureau of Information.

PMID- 29822977
TI  - The Cottage Hospital in Fact: The Management and Administration of a Typical
      Institution.

PMID- 29822978
TI  - The Making of the Modern Practitioner.

PMID- 29822979
TI  - Continuous Current from the Main.

PMID- 29822981
TI  - Post-Anaesthetic Broncho-Pneumonia.

PMID- 29822980
TI  - The Institutional Worker.

PMID- 29822982
TI  - Legal Notes for Institutional Workers.

PMID- 29822983
TI  - The Reck System of Heating.

PMID- 29822984
TI  - Hospital Architecture and Construction.

PMID- 29822985
TI  - Institutional Housekeeping.

PMID- 29822986
TI  - The Dangers of Ignorance at Portsmouth.

PMID- 29822988
TI  - A Hospital Chairman's Grievances : II. Complaints and their Investigation.

PMID- 29822987
TI  - Reports on the Hospitals of the United Kingdom: The Children's Hospital,
      Sheffield; Hospital for Sick Children, Newcastle-on-Tyne.

PMID- 29822990
TI  - A Disclaimer.

PMID- 29822989
TI  - Politics and the Doctor.

PMID- 29822991
TI  - The National Insurance Act Department.

PMID- 29822992
TI  - The Bradford and Other Competitions.

PMID- 29822993
TI  - A Point in Mental Cases: Continuous Administration of Sulphonal.

PMID- 29822994
TI  - The Milk of Eclamptic Mothers: Its Toxicity to Infants Considered.

PMID- 29822995
TI  - Hospital and Institutional News.

PMID- 29822996
TI  - Maternity and Mothering: The Up-to-date Treatment of Ringworm.

PMID- 29822997
TI  - Practical Points: III. How Shorts are Produced.

PMID- 29822998
TI  - King Edward's Fund and the Evelina Hospital.

PMID- 29822999
TI  - National Insurance and the Voluntary Hospitals: Speech by Mr. Worthington Evans,
      M.P.

PMID- 29823000
TI  - A Hospital Chairman's Grievances: I. Complaints and Their Investigation.

PMID- 29823001
TI  - Reports on the Hospitals of the United Kingdom: LXIII. Sunderland and Durham
      County Eye Infirmary.

PMID- 29823002
TI  - The Value of Working-Men's Support.

PMID- 29823003
TI  - Our Bureau of Information.

PMID- 29823004
TI  - A Hospital as a Cinema Theatre.

PMID- 29823005
TI  - Research and Remedies.

PMID- 29823006
TI  - A Reminiscence of Lister.

PMID- 29823007
TI  - The Sick Room Helps Society's New Maternity Home.

PMID- 29823008
TI  - The Institutional Worker.

PMID- 29823009
TI  - A Very "Moderate" Policy.

PMID- 29823010
TI  - Post-Anaesthetic Broncho-Pneumonia : II. Some Points Regarding its Treatment.

PMID- 29823012
TI  - The Jewish Hospital at Berlin.

PMID- 29823011
TI  - Some Thoughts on Public Funerals: A Famous Scientific Surgeon and a Great General
      Practitioner.

PMID- 29823013
TI  - Hospital and Institutional News.

PMID- 29823014
TI  - The Economy of Different Types Compared.

PMID- 29823015
TI  - The Ship's Doctor.

PMID- 29823016
TI  - Some Mental and Moral Aspects of the Strike.

PMID- 29823017
TI  - Management by Committee.

PMID- 29823019
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29823018
TI  - Modern Methods of Treatment: How they Affect the Hospitals and their Patients.

PMID- 29823021
TI  - The Defective and Dependent : VII. The Education of the Physically Defective.

PMID- 29823020
TI  - The Care of Children's Backs.

PMID- 29823023
TI  - The Editor's Letter-Box.

PMID- 29823022
TI  - Hospital Officers: Their Training and Work: The Ideal Hospital Chairman.

PMID- 29823024
TI  - Legal Notes for Institutional Workers.

PMID- 29823025
TI  - Employees and the National Insurance Act: III. Benefits Receivable under the Act.

PMID- 29823027
TI  - League of Mercy.

PMID- 29823026
TI  - Medical Attendance in Cottage Hospitals.

PMID- 29823028
TI  - Reports on the Hospitals of the United Kingdom: LXV. Royal Infirmary, Sunderland.

PMID- 29823030
TI  - The Institutional Worker.

PMID- 29823029
TI  - The Dispensary Keys.

PMID- 29823031
TI  - Institutional Housekeeping.

PMID- 29823032
TI  - Hospital and Institutional News.

PMID- 29823034
TI  - Our Bureau of Information.

PMID- 29823033
TI  - Anti-Vivisection Ethics.

PMID- 29823035
TI  - A Competitor's Point.

PMID- 29823036
TI  - Some Points of View of the Medical Profession.

PMID- 29823038
TI  - Byways of Medical Relief.

PMID- 29823037
TI  - Calcium Carbide as a Caustic in Surgery.

PMID- 29823039
TI  - The X-Rays.

PMID- 29823040
TI  - Medical Opinion and Movement.

PMID- 29823041
TI  - Competitions for Hospital Buildings.

PMID- 29823042
TI  - The Institutional Worker.

PMID- 29823043
TI  - The Insurance of Motherhood.

PMID- 29823044
TI  - Overcrowding in Poor Law Infirmaries.

PMID- 29823045
TI  - The School Clinic.

PMID- 29823046
TI  - The Royal Portsmouth Hospital.

PMID- 29823047
TI  - Employees and the National Insurance Act: IV. Benefits Receivable under the Act
      (Continued).

PMID- 29823048
TI  - The Practitioner's Relaxations and Hobbies.

PMID- 29823049
TI  - Hospital and Institutional News.

PMID- 29823050
TI  - Congenital Stenosis of the Pylorus.

PMID- 29823051
TI  - The Popular Conception of the Specialist.

PMID- 29823052
TI  - Our Bureau of Information.

PMID- 29823053
TI  - Bedford County Hospital.

PMID- 29823054
TI  - Putney to Mortlake: Competitive Athletics.

PMID- 29823055
TI  - How Hospital Income May Be Affected.

PMID- 29823056
TI  - The Hospital Sunday Fund.

PMID- 29823058
TI  - The Diagnosis of Throat and Nose Cases at a School Clinic.

PMID- 29823057
TI  - Competitions for Hospital Buildings: Further Opinions.

PMID- 29823059
TI  - Interested, Though Not Competing.

PMID- 29823060
TI  - The Royal Portsmouth Hospital.

PMID- 29823061
TI  - The Making of a Modern Hospital : The Ward Windows and Doors.

PMID- 29823062
TI  - Employees and the National Insurance Act: II. The Constitution of Approved
      Societies.

PMID- 29823063
TI  - Hospital and Institutional News.

PMID- 29823064
TI  - St. George's Hospital and the Sunday Fund.

PMID- 29823065
TI  - The Institutional Worker.

PMID- 29823067
TI  - Byways of Medical Relief.

PMID- 29823066
TI  - The Treatment of General Peritonitis.

PMID- 29823068
TI  - Research and Remedies.

PMID- 29823069
TI  - National Insurance and the Employees of Hospitals.

PMID- 29823071
TI  - The Report of the Vivisection Commission.

PMID- 29823070
TI  - Our Bureau of Information.

PMID- 29823072
TI  - Round the Hospitals.

PMID- 29823073
TI  - The Medical Profession and the Army.

PMID- 29823074
TI  - Charing Cross Hospital.

PMID- 29823075
TI  - The College of Nursing and State Registration.

PMID- 29823076
TI  - Poking Fun at the Matrons.

PMID- 29823077
TI  - Linen Leagues for Hospitals.

PMID- 29823078
TI  - Hospital and Institutional News.

PMID- 29823079
TI  - Education and Infant Welfare: The Views of the Board of Education on Mothercraft.

PMID- 29823081
TI  - The Chemical Treatment of Tuberculosis.

PMID- 29823080
TI  - Parliament and the Profession.

PMID- 29823082
TI  - Tuberculosis in Wales: Activities of the National Memorial Association.

PMID- 29823083
TI  - Military Medical Notes.

PMID- 29823084
TI  - Textile Supplies for Hospitals: VIII. Sheets and Quilts.

PMID- 29823085
TI  - Orthodoxies and Heresies.

PMID- 29823086
TI  - Hospital Responsibilities-Direct and Indirect.

PMID- 29823087
TI  - A Difficult Problem of Diagnosis.

PMID- 29823089
TI  - Parliament and the Profession.

PMID- 29823088
TI  - Dresses for Hospital Children.

PMID- 29823091
TI  - Industrial Fatigue.

PMID- 29823090
TI  - The Royal National Hospital for Consumption, Ventnor.

PMID- 29823093
TI  - Another Food Fad.

PMID- 29823092
TI  - Additional Responsibility for Hospital Managers.

PMID- 29823095
TI  - The Food Bill at St. George's.

PMID- 29823094
TI  - The Child Delinquent.

PMID- 29823096
TI  - A Medical Causerie.

PMID- 29823097
TI  - Danger of Excess of Economy in Child Welfare Work.

PMID- 29823098
TI  - Hospital and Institutional News.

PMID- 29823099
TI  - Safely Launched and in Port.

PMID- 29823100
TI  - Round the Hospitals.

PMID- 29823101
TI  - The Leicester Royal Infirmary.

PMID- 29823102
TI  - The Leprosy Case.

PMID- 29823104
TI  - Military Amputations. I. A Reversion to Pre-Listerian Methods.

PMID- 29823103
TI  - Withholding the Annual Report: An Explanation Asked for.

PMID- 29823105
TI  - Work for the College of Nursing?

PMID- 29823106
TI  - Parliament and the Profession.

PMID- 29823107
TI  - Hospital and Institutional News.

PMID- 29823108
TI  - On Acute Nephritis in Children: The Importance of Urinalysis in Diseases of the
      Young.

PMID- 29823109
TI  - Shall We Sweat the Crippled Soldier?

PMID- 29823110
TI  - State Registration in Great Britain.

PMID- 29823111
TI  - Round the Hospitals.

PMID- 29823112
TI  - From across the Seas.

PMID- 29823113
TI  - The School Doctor and the Mentally Defective Child.

PMID- 29823114
TI  - The National Medical Union.

PMID- 29823116
TI  - Human Temperaments. III.-The Temperament of the Artist.

PMID- 29823115
TI  - The Bishop's Last.

PMID- 29823118
TI  - The Institutional Treatment of Consumption: V. The Disposal of Sputum.

PMID- 29823117
TI  - Textile Supplies for Hospitals: XII. The Purchasing of Stores.

PMID- 29823120
TI  - Parliament and the Profession.

PMID- 29823119
TI  - A Medical Causerie.

PMID- 29823121
TI  - On Euthanasia.

PMID- 29823122
TI  - Round the Hospitals.

PMID- 29823123
TI  - Some Remarkable Figures and Facts.

PMID- 29823124
TI  - The Mobilisation of the Medical Profession.

PMID- 29823125
TI  - The Nature of the Soul: Some Primitive Ideas.

PMID- 29823126
TI  - From across the Seas.

PMID- 29823128
TI  - The Pioneer of the Sanatorium Idea.

PMID- 29823127
TI  - Where Was the Editor?

PMID- 29823129
TI  - Florence Nightingale and the Royal National Pension Fund for Nurses: Letters and
      Correspondence of Historic Value.

PMID- 29823130
TI  - Welsh Education.

PMID- 29823131
TI  - Advertisements in Voluntary Hospitals.

PMID- 29823133
TI  - Hospital and Institutional News.

PMID- 29823132
TI  - Women Patrols and Women Police.

PMID- 29823134
TI  - The Royal British Nurses' Association.-II.

PMID- 29823135
TI  - Epidemic Jaundice in the Mediterranean Expeditionary Force: Research under
      Difficulties.

PMID- 29823137
TI  - Parliament and the Profession.

PMID- 29823136
TI  - The Interim Report of the Committee of Inquiry.

PMID- 29823138
TI  - Round the Hospitals.

PMID- 29823139
TI  - The Education of the Probationer.

PMID- 29823141
TI  - A Medical Causerie.

PMID- 29823140
TI  - New South London Hospital for Women: The Operation Unit.

PMID- 29823142
TI  - The Institutional Treatment of Consumption: VI. Records and Classification of
      Patients.

PMID- 29823143
TI  - Patriotism and Nurse-Training Schools: VII. Training Schools South and West.

PMID- 29823144
TI  - Hospital and Institutional News.

PMID- 29823145
TI  - The Twilight Sleep Propaganda: A Danger to the Race.

PMID- 29823146
TI  - The Public and the General Practitioner.

PMID- 29823147
TI  - Textile Supplies for Hospitals: X. Sheets, Towels, and Table Linens.

PMID- 29823148
TI  - Round the Hospitals.

PMID- 29823149
TI  - Hospital and Institutional News.

PMID- 29823150
TI  - The College of Nursing Meeting.

PMID- 29823151
TI  - Parliament and the Profession.

PMID- 29823152
TI  - Ideals for the Future.

PMID- 29823153
TI  - With the Wounded: The Growing and Propagation of Bulbs.

PMID- 29823154
TI  - The Matrons' Experiences.

PMID- 29823155
TI  - A Garden Colony for Consumptives.

PMID- 29823156
TI  - Cerebro-Spinal Meningitis: Some of Its Problems.

PMID- 29823157
TI  - The Civil Hospitals and the War Office.

PMID- 29823158
TI  - "Riders" by Coroners' Juries.

PMID- 29823159
TI  - The College of Nursing, Limited.

PMID- 29823160
TI  - From Across the Seas: Where Babies Thrive-Antipodean Salaries-The Surgeon's
      Pledge.

PMID- 29823161
TI  - The Inquiry and after.

PMID- 29823162
TI  - London and Counties Medical Protection Society.

PMID- 29823163
TI  - St. George's Hospital.

PMID- 29823164
TI  - Necessitous Ladies' Holiday Fund.

PMID- 29823165
TI  - Some Disabilities from War Injuries.

PMID- 29823167
TI  - Mixed Classes in Medical Education.

PMID- 29823166
TI  - Nurse Training in War-Time.

PMID- 29823168
TI  - Textile Supplies for Hospitals: XIII. The Care of Textiles.

PMID- 29823170
TI  - Economic Conditions in Nurse-Training.

PMID- 29823169
TI  - The Reduction of Infant Mortality: The Priestley Lecture, by the Duchess of
      Marlborough.

PMID- 29823171
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29823172
TI  - Human Temperaments. VI.-The Man of Business.

PMID- 29823173
TI  - Hospital and Institutional News.

PMID- 29823174
TI  - Round the Hospitals.

PMID- 29823175
TI  - South London Hospital for Women.

PMID- 29823176
TI  - The Convalescent Soldier: Wakeswood Home, near Andover.

PMID- 29823177
TI  - Methods Military and Medical.

PMID- 29823178
TI  - The Incorporated Society of Trained Masseuses.

PMID- 29823179
TI  - Round the Hospitals.

PMID- 29823180
TI  - Hospital Construction.

PMID- 29823181
TI  - Defects of Hearing.

PMID- 29823182
TI  - Self-Denial in a Minor Key.

PMID- 29823183
TI  - Hospital and Institutional News.

PMID- 29823184
TI  - Insanity and Temperament. II.-The Artistic Temperament.

PMID- 29823186
TI  - Parliament and the Profession.

PMID- 29823185
TI  - Nurse-Training, Small Hospitals, and the College of Nursing.

PMID- 29823187
TI  - Shakespeare's Medical Knowledge: "One of Our Greatest Masters of Medicine".

PMID- 29823188
TI  - Nursing in the United States.

PMID- 29823189
TI  - The Miller General Hospital.

PMID- 29823190
TI  - The Surgery of Fractures.

PMID- 29823191
TI  - The Editor's Letter-Box.

PMID- 29823192
TI  - Textile Supplies for Hospitals: XI. Surgical Dressings.

PMID- 29823193
TI  - University Education in Wales: A Royal Commission Appointed.

PMID- 29823194
TI  - The Problem of Tuberculosis: The Patient, the Nurse, and Questions of Economy.

PMID- 29823195
TI  - A Matron's Worries.

PMID- 29823196
TI  - Legal Notes for Institutional Workers.

PMID- 29823197
TI  - Child Welfare Work in Bradford: Hospital and Municipal Work Compared.

PMID- 29823198
TI  - Easter Day, 1916.

PMID- 29823199
TI  - Erratum: A Correction.
AB  - [This corrects the article on p. 63 in vol. 60.].

PMID- 29823200
TI  - Parliament and the Profession.

PMID- 29823201
TI  - National Egg Scandal.

PMID- 29823202
TI  - Ambulance Dogs.

PMID- 29823203
TI  - Medical Fees within the Profession.

PMID- 29823204
TI  - The Editor's Letter-Box.

PMID- 29823205
TI  - Hospital and Institutional News.

PMID- 29823206
TI  - A Medical Causerie.

PMID- 29823207
TI  - The Human Body: Its Plan of Organisation.

PMID- 29823208
TI  - The Enrolment Scheme and the Profession.

PMID- 29823210
TI  - Round the Hospitals.

PMID- 29823209
TI  - Some Difficulties with V.A.D. Workers.

PMID- 29823211
TI  - The Hospital Laundry: I. Its Constituent Parts, Equipment, and Staff.

PMID- 29823212
TI  - Charing Cross Hospital.

PMID- 29823213
TI  - Gas in Military Mines: The Symptoms of Carbon Monoxide Poisoning.

PMID- 29823214
TI  - The Institutional Treatment of Consumption: II. Routine Time-Tables and Diet
      Scales.

PMID- 29823215
TI  - Hospital and Institutional News.

PMID- 29823216
TI  - Nursing in the United States.

PMID- 29823217
TI  - The Medical Profession: Compulsory or Voluntary Service?

PMID- 29823218
TI  - Diagnosis and Personality.

PMID- 29823220
TI  - Round the Hospitals.

PMID- 29823219
TI  - The "Artistic Temperament": The Real Artist's Temperament Analysed.

PMID- 29823221
TI  - Remodelling a Hospital Garden: A Practical Example at Hertford.

PMID- 29823222
TI  - A Great Meeting in Edinburgh.

PMID- 29823223
TI  - A Medical Causerie.

PMID- 29823224
TI  - A Decision of the Court of Appeal and Its Effects on the Right to Benefits.

PMID- 29823225
TI  - A Desecration of Florence Nightingale's Statue.

PMID- 29823226
TI  - The Radcliffe Infirmary, Oxford.

PMID- 29823227
TI  - Parliament and the Profession.

PMID- 29823228
TI  - Hospital and Institutional News.

PMID- 29823229
TI  - The Institutional Treatment of Consumption: VII. Notes on Administration in a
      Sanatorium.

PMID- 29823230
TI  - The Alimentary Rest Treatment of Diabetes: Some Details of a Promising Regimen.

PMID- 29823231
TI  - Children's Country Holidays Fund: Letter from the Bishop of London.

PMID- 29823232
TI  - The Praise of Fools.

PMID- 29823233
TI  - The Hospital Drug Supply: A Word of Caution to Buyers.

PMID- 29823235
TI  - A Satisfactory Financial Position.

PMID- 29823234
TI  - Round the Hospitals.

PMID- 29823236
TI  - Cheap Prescribing.

PMID- 29823237
TI  - A Medical Causerie.

PMID- 29823239
TI  - Nurses' Looks.

PMID- 29823238
TI  - The Control of Lay Women in Hospitals.

PMID- 29823240
TI  - Names in Nursing: A Call for Definitions in Terms.

PMID- 29823241
TI  - The Feeding of Patients and Staff.

PMID- 29823242
TI  - Economy in the Annual Report.

PMID- 29823244
TI  - Institutional Needs.

PMID- 29823243
TI  - The National Egg Collection for the Wounded.

PMID- 29823245
TI  - A Medical Causerie.

PMID- 29823246
TI  - The Interim Report of the Committee of Inquiry.

PMID- 29823247
TI  - Hospital and Institutional News.

PMID- 29823248
TI  - The Certificate of the Cause of Death.

PMID- 29823249
TI  - The Military Service Acts and the Profession.

PMID- 29823250
TI  - Internal Secretions and Their Functions: A New Chapter in Modern Physiology.

PMID- 29823252
TI  - The Royal Free Hospital and the War.

PMID- 29823251
TI  - School Medical Inspection in the Transvaal: A Record of Progress.

PMID- 29823253
TI  - The Institutional Treatment of Consumption: IV. Sanatorium Buildings and
      Equipment.

PMID- 29823254
TI  - The General Nursing Council and College of Nursing: A Draft Registration Bill
      Agreed to.

PMID- 29823255
TI  - Round the Hospitals.

PMID- 29823256
TI  - The English of Medical Writers.

PMID- 29823257
TI  - First Draft of Agreed Bill.

PMID- 29823258
TI  - Charity Commission's Memorandum.

PMID- 29823260
TI  - The Clean Milk Campaign.

PMID- 29823259
TI  - Neurasthenia: A Distinct and Specific Pathological Condition.

PMID- 29823261
TI  - Mental Nurses in Military Hospitals.

PMID- 29823262
TI  - Doctors and Friendly Societies in New Zealand.

PMID- 29823263
TI  - The Future of British Nursing : III.-Training and Certification.

PMID- 29823264
TI  - Hospital and Institutional News.

PMID- 29823265
TI  - A Federal Report on Veneral Diseases: Drastic Proposals.

PMID- 29823267
TI  - The College of Nursing.

PMID- 29823266
TI  - The Notification of Venereal Diseases.

PMID- 29823269
TI  - Royal United Hospital, Bath.

PMID- 29823268
TI  - Patients and Nurses: Complaints of Familiarity.

PMID- 29823270
TI  - Twilight Anaesthesia in Labour.

PMID- 29823271
TI  - The New Unemployment Insurance Act.

PMID- 29823273
TI  - County Councils and Public Health.

PMID- 29823272
TI  - Macedonia in War-Time: Its Country and Inhabitants.

PMID- 29823274
TI  - The Institutional Treatment of Consumption: III. Gradation of Work and Exercise.

PMID- 29823275
TI  - Organisation in the Medical Profession.

PMID- 29823276
TI  - Hospital and Institutional News.

PMID- 29823277
TI  - Epsom College.

PMID- 29823279
TI  - Military Amputations. II. The Treatment of Stumps in Preparation for Artificial
      Limbs.

PMID- 29823278
TI  - A Medical Causerie.

PMID- 29823281
TI  - Annual Meeting of Governors and General Council.

PMID- 29823280
TI  - Foods, Fats, and Feeding.

PMID- 29823283
TI  - Round the Hospitals.

PMID- 29823282
TI  - Household Management.

PMID- 29823284
TI  - Legal Notes for Institutional Workers.

PMID- 29823285
TI  - Nursing in the United States.

PMID- 29823287
TI  - The Institutional Treatment of Consumption: I. The Sorting of the Patients.

PMID- 29823286
TI  - A Medical Causerie.

PMID- 29823288
TI  - Parliament and the Profession.

PMID- 29823289
TI  - Round the Hospitals.

PMID- 29823291
TI  - Toronto General Hospital: Accommodation 700 Patients.

PMID- 29823290
TI  - St. Thomas's and the War.

PMID- 29823292
TI  - State Registration in America.

PMID- 29823293
TI  - The Tragic Tale of Wittenberg: Shall There Be Medical Reprisals?

PMID- 29823294
TI  - St. George's Hospital.

PMID- 29823295
TI  - The State Endowment of Motherhood.

PMID- 29823296
TI  - Some Messages of the War.

PMID- 29823297
TI  - Hospital and Institutional News.

PMID- 29823298
TI  - Edward Livingston Trudeau, M.D., and R. L. Stevenson: Fellow-Sufferers from
      Tuberculosis.

PMID- 29823299
TI  - Insanity and Temperament. I.-Mediaeval v. Modern Ideas in Medicine.

PMID- 29823300
TI  - The Norfolk and Norwich Hospital, 1771-1847.

PMID- 29823302
TI  - A Medical Writer Who Missed His Vocation.

PMID- 29823301
TI  - How to Run a Laundry: II. The Week's Work.

PMID- 29823303
TI  - Guy's Hospital.

PMID- 29823304
TI  - St. Thomas's Hospital.

PMID- 29823305
TI  - A Leading Case at Edinburgh.

PMID- 29823306
TI  - Mental Nurses in Military Hospitals.

PMID- 29823307
TI  - Hospital and Institutional News.

PMID- 29823308
TI  - The Hospital of the Future.

PMID- 29823309
TI  - Sir George Newman on the School Child: The Arousing of the National Conscience.

PMID- 29823310
TI  - The Work of the Canadian Medical Service.

PMID- 29823312
TI  - Some Human Lessons in War-Time: II. The Physician and the Preacher.

PMID- 29823311
TI  - Round the Hospitals.

PMID- 29823314
TI  - A Municipal Milk Supply.

PMID- 29823313
TI  - The Final Court of Appeal.

PMID- 29823316
TI  - From Across the Seas: Meat Prices; Cooking; the Staff's Liabilities.

PMID- 29823315
TI  - The Example of the American Hospital Association.

PMID- 29823318
TI  - Hospital and Institutional News.

PMID- 29823317
TI  - Some Difficulties with V.A.D. Workers.

PMID- 29823320
TI  - Round the Hospitals.

PMID- 29823319
TI  - Parliament and the Profession.

PMID- 29823322
TI  - Textile Supplies for Hospitals: IX. Cotton Uniforms.

PMID- 29823321
TI  - The New Taxes.

PMID- 29823323
TI  - The Man and the Moment.

PMID- 29823324
TI  - Who Is Insane?

PMID- 29823326
TI  - The College of Nursing: Great Meeting at St. Thomas's Hospital: Full Verbatim
      Report.

PMID- 29823325
TI  - Tubercular Patients on a Hill.

PMID- 29823327
TI  - Scotland's First Open-Air Hospital.

PMID- 29823329
TI  - Vacancies for Midwives.

PMID- 29823328
TI  - Criminal Germans and British Prisoners: A Terrible Story of Brutal Cruelty:
      Heroic British Practitioners.

PMID- 29823331
TI  - The Glad Eye of Observation.

PMID- 29823330
TI  - The Royal Hospital for Incurables.

PMID- 29823332
TI  - Typhoid Fever: Treatment in the Army.

PMID- 29823333
TI  - Highland and Islands Medical Service Board: A Policy of Cautiousness.

PMID- 29823334
TI  - The School Doctor and the Tuberculous Child.

PMID- 29823335
TI  - The Royal British Nurses' Association.-I.

PMID- 29823336
TI  - Human Temperaments. V.-The Faddist.

PMID- 29823338
TI  - The Compulsory Removal of Phthisical Patients.

PMID- 29823337
TI  - National Training School for District Midwives.

PMID- 29823340
TI  - Special Hospital Sunday Supplement.

PMID- 29823339
TI  - The Lady House Surgeon.

PMID- 29823341
TI  - Hospital Nursing in War-Time: Disadvantages of Depleted Staffs.

PMID- 29823342
TI  - What Is Medical Responsibility?

PMID- 29823343
TI  - Round the Hospitals.

PMID- 29823344
TI  - The Doctor's Indifference.

PMID- 29823345
TI  - The Extensor Response (Babinski's Sign): Its Positive and Negative Value.

PMID- 29823346
TI  - Hospital and Institutional News.

PMID- 29823347
TI  - A Shortage of Catgut.

PMID- 29823349
TI  - Research and Remedies.

PMID- 29823348
TI  - Children's Country Holidays Fund.

PMID- 29823350
TI  - Bristol General Hospital.

PMID- 29823351
TI  - The Drug Resources of the Colonies.

PMID- 29823353
TI  - Human Temperaments. VII.-The Religious Temperament.

PMID- 29823352
TI  - Parliament and the Profession.

PMID- 29823354
TI  - Post-Mortem Caesarean Section: A Question of Law for Institutional Officers.

PMID- 29823355
TI  - Australian Notes.

PMID- 29823357
TI  - Some Encouraging Experiences.

PMID- 29823356
TI  - The Twilight Sleep Propaganda.

PMID- 29823358
TI  - Hospital and Institutional News.

PMID- 29823359
TI  - War, Warriors, and Nurses.

PMID- 29823360
TI  - The Hospitals and Women Students.

PMID- 29823361
TI  - The Equipment of Research Laboratories: Some Applications of Gas Heating.

PMID- 29823362
TI  - The War Charities Committee.

PMID- 29823364
TI  - Round the Hospitals.

PMID- 29823363
TI  - The Editor's Letter-Box.

PMID- 29823365
TI  - Sir Perceval A. Nairne: Our Sailors and Their Benefactors.

PMID- 29823366
TI  - The Cocaine Habit: Government Action at Last.

PMID- 29823367
TI  - The Training for Masseuses.

PMID- 29823368
TI  - The Bill Approved by the College Council.

PMID- 29823369
TI  - From across the Seas.

PMID- 29823370
TI  - Human Temperaments. VIII.-The Practical Man.

PMID- 29823371
TI  - Well Done, Nursing Staff! Next Please.

PMID- 29823373
TI  - Round the Hospitals.

PMID- 29823372
TI  - The Leeds Infirmary and a Justice of Assize.

PMID- 29823375
TI  - Medical Studies and Mnemonics.

PMID- 29823374
TI  - The London Hospital: An Immediate Need.

PMID- 29823376
TI  - Commandant and Matron.

PMID- 29823377
TI  - Hospital and Institutional News.

PMID- 29823378
TI  - More V.A.D.s of All Ranks Wanted.

PMID- 29823380
TI  - How the Law Regards the Loss of One Eye.

PMID- 29823379
TI  - The Control of Lay Women in Hospitals.

PMID- 29823382
TI  - The Sale of Medicated Wines.

PMID- 29823381
TI  - Surgical Operations without Shock.

PMID- 29823383
TI  - The Catholicity of Medicine.

PMID- 29823384
TI  - Round the Hospitals.

PMID- 29823386
TI  - NOT "Good Enough for the War."

PMID- 29823385
TI  - Local War Committees and Local Authorities.

PMID- 29823387
TI  - Parliament and the Profession.

PMID- 29823388
TI  - Hospital and Institutional News.

PMID- 29823389
TI  - Distribution of Awards.

PMID- 29823390
TI  - The Case of St. Bartholomew's Hospital.

PMID- 29823391
TI  - Human Temperaments. IX.-The Envious Temperament.

PMID- 29823392
TI  - Free Drugs and State Control.

PMID- 29823393
TI  - A New Treatment for Infected Wounds: Bismuth and Iodoform Paste.

PMID- 29823394
TI  - The National Medical Union and the Insurance Acts.

PMID- 29823395
TI  - Grave Crisis for Poor-Law Nurses.

PMID- 29823396
TI  - Our Hospitals and the National Relief Fund.

PMID- 29823397
TI  - The College of Nursing: Some Absurdities and a Warning.

PMID- 29823399
TI  - Hospital and Institutional News.

PMID- 29823398
TI  - Matters to Be Discussed.

PMID- 29823400
TI  - Round the Hospitals.

PMID- 29823401
TI  - The Editor's Letter-Box.

PMID- 29823402
TI  - On Ocular Symptoms in Tabes Dorsalis: Local Symptoms of a General Import.

PMID- 29823403
TI  - Hospital for Tropical Diseases, Calcutta.

PMID- 29823404
TI  - Haematuria in Tumours of the Bladder.

PMID- 29823405
TI  - Remedies for the Neglect of Science.

PMID- 29823406
TI  - The Penal Powers of the General Medical Council.

PMID- 29823407
TI  - Economy in the Annual Report.

PMID- 29823409
TI  - Points from the Quarterly Report.

PMID- 29823408
TI  - Fire Extinguishers: A Point for Institutional Managers.

PMID- 29823411
TI  - The English of Medical Writings.

PMID- 29823410
TI  - Qualifications for Admission to the Register.

PMID- 29823413
TI  - Human Temperaments. IV.-Cleverness and Capability.

PMID- 29823412
TI  - Auxiliary and Other Military Hospitals.

PMID- 29823415
TI  - The School Doctor and the Mentally Defective Child.

PMID- 29823414
TI  - Parliament and the Profession.

PMID- 29823417
TI  - The Percy Treatment of Carcinoma of the Uterus: An Ingenious Adaptation of the
      Cautery.

PMID- 29823416
TI  - An Unhappy Subscription Method.

PMID- 29823418
TI  - Some Human Lessons in War-Time: I. The Nation and the Great War.

PMID- 29823419
TI  - The Sphagnum-Moss Gatherers.

PMID- 29823420
TI  - The Supply of Nurses Committee.

PMID- 29823421
TI  - Two Military Hospital Gazettes.

PMID- 29823422
TI  - The School Doctor and School Feeding.

PMID- 29823423
TI  - The Birmingham General Hospital.

PMID- 29823424
TI  - Legal Notes for Institutional Workers.

PMID- 29823425
TI  - The National Mission.

PMID- 29823427
TI  - Hospital and Institutional News.

PMID- 29823426
TI  - The College of Nursing: A Glasgow View.

PMID- 29823428
TI  - Human Temperaments. XI.-The Man of Action.

PMID- 29823429
TI  - Round the Hospitals.

PMID- 29823430
TI  - Hospitals and the Spirit Tax.

PMID- 29823432
TI  - Round the Hospitals.

PMID- 29823431
TI  - Mental Nurses and War Hospital Work.

PMID- 29823433
TI  - Hospital and Institutional News.

PMID- 29823434
TI  - Nurses' Indoor Uniform in the Streets: Unhygienic and Unprofessional.

PMID- 29823435
TI  - Out-Patients and the War: The Experiences of Westminster Hospital.

PMID- 29823436
TI  - The State Treatment of Venereal Diseases: The New Regulations.

PMID- 29823438
TI  - Some Hospital Statistics: Their Use and Value.

PMID- 29823437
TI  - Surbiton Cottage Hospital and the Sunday Fund Award.

PMID- 29823440
TI  - Mental Nurses in Military Hospitals.

PMID- 29823439
TI  - Parliament and the Profession.

PMID- 29823442
TI  - A New Use for Hospital Gardens: The Cultivation of Medicinal Herbs.

PMID- 29823441
TI  - Increased Income for Charitable Institutions: The Fulfilment of a Patriotic Duty.

PMID- 29823443
TI  - Some Ward Sisters and Staff Nurses Protest.

PMID- 29823445
TI  - The Future of British Nursing : II.-Training and Certification.

PMID- 29823444
TI  - National Poor-Law Officers' Association, Incorporated.

PMID- 29823446
TI  - Human Temperaments. X.-The Jealous Temperament.

PMID- 29823447
TI  - The Fourth Annual Report.

PMID- 29823448
TI  - Hospital and Institutional News.

PMID- 29823449
TI  - Round the Hospitals.

PMID- 29823450
TI  - Work of the past Quarter.

PMID- 29823451
TI  - Anthrax in the Shaving-Brush-Japanese Shave without Soap.

PMID- 29823452
TI  - The Horton Infirmary, Banbury.

PMID- 29823453
TI  - Sir Peter Eade.

PMID- 29823455
TI  - Experimental Tuberculous Meningitis.

PMID- 29823454
TI  - Some Hospital Statistics: Their Use and Value.

PMID- 29823456
TI  - Why It Cannot Represent Trained Nurses.

PMID- 29823457
TI  - Infantile Paralysis or Acute Anterior Poliomyelitis: Its Symptoms and Treatment.

PMID- 29823458
TI  - The Hospitals' Harvest Time.

PMID- 29823459
TI  - Our Hospitals and the National Relief Fund: More Facts and Figures.

PMID- 29823460
TI  - Hospital and Institutional News.

PMID- 29823461
TI  - Parliament and the Profession.

PMID- 29823462
TI  - Infantile Diphtheria: A Special Danger in the First Year of Life.

PMID- 29823463
TI  - Economy in the Isolation Hospital.

PMID- 29823464
TI  - Relief in Belgium.

PMID- 29823465
TI  - The Future of British Nursing: I. Nurses and Central Examinations.

PMID- 29823466
TI  - Our Hospitals and the National Relief Fund.

PMID- 29823467
TI  - The Representative Meeting of the British Medical Association.

PMID- 29823468
TI  - Children of the State: The Nation's Debt to Its Warriors.

PMID- 29823469
TI  - Round the Hospitals.

PMID- 29823470
TI  - The Middlesex Hospital Reports.

PMID- 29823472
TI  - Tropical Medicine.

PMID- 29823471
TI  - Our Hospitals and the National Relief Fund: A Provincial Hospital Secretary's
      Views.

PMID- 29823473
TI  - Sir James Mackenzie on Heart Affections.

PMID- 29823474
TI  - Woman's Work in Medicine after the War.

PMID- 29823476
TI  - Qualifications and Regulations.

PMID- 29823475
TI  - The Medical Schools of the United Kingdom.

PMID- 29823478
TI  - An Early Eighteenth-Century Anatomy Lecture Room.

PMID- 29823477
TI  - Dentistry as a Profession: Its Drawbacks and Preparations to Qualify.

PMID- 29823480
TI  - Compulsory Service in the R.A.M.C.: How the Profession Has Avoided Direct
      Governmental Control.

PMID- 29823479
TI  - The Medical School's Entry in War Time.

PMID- 29823481
TI  - A Jumbled Argument.

PMID- 29823482
TI  - The Royal Naval Medical Service: Its Claims and Advantages.

PMID- 29823483
TI  - Erratum.
AB  - [This corrects the article on p. 401 in vol. 60.].

PMID- 29823484
TI  - Royal Army Medical Corps.

PMID- 29823486
TI  - Hospital and Institutional News.

PMID- 29823485
TI  - The Editor's Letter-Box.

PMID- 29823487
TI  - Indian Medical Service.

PMID- 29823488
TI  - Colonial Medical Service.

PMID- 29823489
TI  - Research in Medicine: Its Need of Endowment and Outlook.

PMID- 29823491
TI  - The British Hospitals Association.

PMID- 29823490
TI  - The Future of Insurance Practice.

PMID- 29823493
TI  - Graduate Study in London Special Hospitals.

PMID- 29823492
TI  - The Medical Curriculum.

PMID- 29823494
TI  - London Post-Graduate Institutions.

PMID- 29823495
TI  - The Public Health Service: Its Wide Field, Needs and Future.

PMID- 29823496
TI  - The Royal Army Medical Corps: How Matters Stand To-Day.

PMID- 29823497
TI  - The Report of the Recent Committee.

PMID- 29823499
TI  - The Salaries of Deputising Medical Officers.

PMID- 29823498
TI  - My Experiences in a Field Ambulance.

PMID- 29823500
TI  - Hospitals and the War.

PMID- 29823501
TI  - Hospital and Institutional News.

PMID- 29823503
TI  - A Good Clinician.

PMID- 29823502
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823504
TI  - The Welsh War Hospital, Netley: The Movable Hospital to Be Opened Next Week.

PMID- 29823505
TI  - Scenes in the Busiest Week of the War.

PMID- 29823507
TI  - The Cumberland Infirmary, Carlisle.

PMID- 29823506
TI  - The Ambulance Dog in War.

PMID- 29823509
TI  - The Royal Infirmary, Preston.

PMID- 29823508
TI  - The London Panel Committee.

PMID- 29823511
TI  - The British Pharmacopoeia.

PMID- 29823510
TI  - The Transport of Wounded: The Official Descriptive Statement by the Press Bureau.

PMID- 29823512
TI  - Types of Motor Ambulance Waggons: The St. Andrew's Association's Models.

PMID- 29823513
TI  - Unqualified Assistants for Infirmary Staffs.

PMID- 29823515
TI  - Hospital and Institutional News.

PMID- 29823514
TI  - A Comparison of Hospital Expenditure in 1913 with 1912.

PMID- 29823516
TI  - Conditions of Service of Army Compounders.

PMID- 29823518
TI  - The Institutional Library.

PMID- 29823517
TI  - Erratum: The Cumberland Infirmary, Carlisle.
AB  - [This corrects the article on p. 677 in vol. 56.].

PMID- 29823519
TI  - New Government Grants.

PMID- 29823520
TI  - The Work of London and Provincial Hospitals.

PMID- 29823522
TI  - Physical Fitness and the Healing of Wounds.

PMID- 29823521
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823524
TI  - With a British Field Ambulance in August.

PMID- 29823523
TI  - The Cottage Hospital, Staines.

PMID- 29823525
TI  - The Care of the Soldiers in Provincial Hospitals.

PMID- 29823526
TI  - The Role of the Physician in Time of War.

PMID- 29823527
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823528
TI  - Hospital and Institutional News.

PMID- 29823529
TI  - The Use of the Red Cross.

PMID- 29823531
TI  - Radio-Therapeutic Department at New King's: Official Account of Its Plan and
      Equipment.

PMID- 29823530
TI  - Experiences on H.M.S. "Aboukir": The Action of Torpedoes and Submarines.

PMID- 29823533
TI  - The Tuberculosis Danger among Recruits.

PMID- 29823532
TI  - Proposed Special Service (Cholera) Corps.

PMID- 29823535
TI  - The London Panel Committee: Tuesday's Decisions.

PMID- 29823534
TI  - The Needs of Wounded Women.

PMID- 29823536
TI  - Latest Arrivals in London Hospitals.

PMID- 29823537
TI  - The Value of Active Co-Operation by Civilians.

PMID- 29823538
TI  - Report of the King's Fund Convalescent Homes Committee.

PMID- 29823539
TI  - Annual Meeting to Award Grants.

PMID- 29823540
TI  - The New Pharmacopoeia: Its Omissions, Additions, Changes, and Other Features.

PMID- 29823541
TI  - Hospitals and the War.

PMID- 29823542
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823543
TI  - Report of the King's Fund Distribution Committee.

PMID- 29823545
TI  - Annual Meeting of Presidents at St. James's Palace.

PMID- 29823544
TI  - "Canvassing Will Disqualify" (?).

PMID- 29823546
TI  - The Medical Profession and Public Holidays.

PMID- 29823547
TI  - The Local Government Board's Opportunity.

PMID- 29823548
TI  - Hospital and Institutional News.

PMID- 29823549
TI  - Benzol in Leukaemia.

PMID- 29823550
TI  - The Advancement of the Science of Healing.

PMID- 29823551
TI  - Grants Recommended by the Distribution Committee.

PMID- 29823552
TI  - Faulty Administration from Ignorance of Modern Hospital Progress.

PMID- 29823553
TI  - Work for the Wounded of the Allied Armies.

PMID- 29823554
TI  - The Work of the R.A.M.C. in the War: The Regimental Medical Officer's Duties.

PMID- 29823556
TI  - Wounded Transferred to Dreadnought Hospital: Excellence of the Navy Transport
      System.

PMID- 29823555
TI  - The Naval Red Cross Train in London: Great Northern Central Hospital.

PMID- 29823557
TI  - Dr. Ellwood on Medical Gardening: Public Pharmacists' and Dispensers'
      Association.

PMID- 29823558
TI  - Work of the Heaviest Week of the War.

PMID- 29823559
TI  - Medical Men as Prisoners of War.

PMID- 29823560
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823562
TI  - Hospital and Institutional News.

PMID- 29823561
TI  - What the London Hospitals Are Doing.

PMID- 29823563
TI  - The Institutional Future.

PMID- 29823564
TI  - The Territorial Hospital, Leicester.

PMID- 29823565
TI  - A Foreword to Fellow-Workers.

PMID- 29823566
TI  - An Irish Hospital Train.

PMID- 29823567
TI  - Journalism and the Hospitals.

PMID- 29823568
TI  - Louisa Warnes, 1836-1914.

PMID- 29823569
TI  - What a Storehouse Is the Voluntary Hospital!

PMID- 29823570
TI  - Hospital and Institutional News.

PMID- 29823572
TI  - The Motor-Cycle Ambulance.

PMID- 29823571
TI  - The Growth of Hospital Literature: The New Tendency and Its Significance.

PMID- 29823574
TI  - Some Home-Made Hospital Equipment: Examples from Leicester.

PMID- 29823573
TI  - The Work of London and Provincial Hospitals.

PMID- 29823575
TI  - King Edward's Hospital Fund for London Statistics (First Notice).

PMID- 29823576
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823577
TI  - The Southern Territorial Hospital, Portsmouth.

PMID- 29823578
TI  - The Guiding Principles of the Scheme.

PMID- 29823580
TI  - Imperfections in the Cumberland Infirmary.

PMID- 29823579
TI  - Soldiers and the Provincial Hospitals.

PMID- 29823581
TI  - Institutional Needs.

PMID- 29823582
TI  - The Fifth Northern General Hospital, Leicester.

PMID- 29823584
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823585
TI  - Hospital and Institutional News.

PMID- 29823583
TI  - The Cumberland Infirmary, Carlisle.

PMID- 29823587
TI  - Hints for Prospective Followers of the Newcastle Plan.

PMID- 29823586
TI  - The Recreations of Convalescing Soldiers.

PMID- 29823588
TI  - Work for the Wounded of the Allied Armies.

PMID- 29823589
TI  - Bones of Contention in Institution Discipline.

PMID- 29823591
TI  - Motor-Cars as Ambulance Wagons.

PMID- 29823590
TI  - The Unallotted Fund and Excessive Prescribing.

PMID- 29823592
TI  - The Special Wards for Wounded Soldiers.

PMID- 29823593
TI  - A Critical View of the King's Fund.

PMID- 29823594
TI  - Mental Institutions and the War.

PMID- 29823595
TI  - Panel Doctors and Panel Chemists.

PMID- 29823596
TI  - The National Medical Union and the L90,000 to Panel Doctors.

PMID- 29823598
TI  - The Specification for the Newcastle Temporary Wards.

PMID- 29823597
TI  - Poor-Law Infirmaries and Union Hospitals: An Inquiry and Scheme Suggested.

PMID- 29823600
TI  - A Brighton Infirmary for Indian Troops.

PMID- 29823599
TI  - A Suggested New Flag for Hospitals.

PMID- 29823601
TI  - Hospital and Institutional News.

PMID- 29823602
TI  - Non-Official Hospitals and the British Red Cross Society.

PMID- 29823603
TI  - The Place of Appeals in Hospital Support.

PMID- 29823604
TI  - Work for the Wounded of the Allied Armies.

PMID- 29823605
TI  - Discipline in Sanatoria : The Grumbles of Working-Class Patients.

PMID- 29823606
TI  - Review of the Problems at the Quarterly Court.

PMID- 29823607
TI  - Vacant Appointments : Should Canvassing Be Encouraged or Forbidden?

PMID- 29823608
TI  - Surgical Experiences in the Present War: A Fruitful Field of Research.

PMID- 29823609
TI  - The Resignation of Sir Edward Wood, J.P.

PMID- 29823611
TI  - Hospital Pharmacists and Olive Oil: Official Tests.

PMID- 29823610
TI  - Seasonable Appeals in 1914.

PMID- 29823613
TI  - How Not to Face a Consultant.

PMID- 29823612
TI  - A Hospital for Soldiers Suffering from Shock.

PMID- 29823614
TI  - The Mental Deficiency Act: Difficulties of Administration. Much Work- Small
      Results.

PMID- 29823615
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823617
TI  - Some Smaller Hospitals and the Wounded.

PMID- 29823616
TI  - Institutional Needs.

PMID- 29823618
TI  - "Really Heroic Work": The Unequalled Efficiency of the R.A.M.C.

PMID- 29823619
TI  - The New Pathological Building at Glasgow Royal Infirmary.

PMID- 29823620
TI  - The London Panel Committee.

PMID- 29823621
TI  - Work for the Wounded of the Allied Armies.

PMID- 29823623
TI  - The War and Nervous Diseases.

PMID- 29823622
TI  - Discipline in Convalescent Homes.

PMID- 29823624
TI  - Hospital and Institutional News.

PMID- 29823625
TI  - The State Control of Research.

PMID- 29823626
TI  - Sidelights upon the War: Reflections and Reminiscences.

PMID- 29823627
TI  - Hospital Statistics.

PMID- 29823628
TI  - The Wounded, the Women of England, and the Voluntary Hospitals.

PMID- 29823629
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823630
TI  - Some Special Features of Importance.

PMID- 29823631
TI  - A "Close" Time for Emotional Givers.

PMID- 29823632
TI  - A Voluntary Insurance Bill.

PMID- 29823633
TI  - The London Panel Committee.

PMID- 29823634
TI  - The Questions of Age and Maximum Efficiency.

PMID- 29823635
TI  - Care for Nerve Cases.

PMID- 29823636
TI  - Hospital and Institutional News.

PMID- 29823637
TI  - Hospitals and the War: Work for the Wounded of the Allied Armies.

PMID- 29823638
TI  - The Royal Infirmary, Glasgow: The Genesis of the Scheme.

PMID- 29823639
TI  - The Fees of Institution Medical Officers.

PMID- 29823641
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823640
TI  - State Children and the War.

PMID- 29823642
TI  - The Drug Treatment of Disease.

PMID- 29823643
TI  - The Making of a Military Hospital: How the Transformation at Cardiff Was
      Effected.

PMID- 29823644
TI  - Christmas in the Institutions.

PMID- 29823645
TI  - Annual Meeting of Constituents.

PMID- 29823646
TI  - Hospitals and the War.

PMID- 29823647
TI  - Evacuation Difficulties : The Triumph of the Motor Ambulance.

PMID- 29823648
TI  - Soldiers' Dental Aid Fund.

PMID- 29823650
TI  - Hospital and Institutional News.

PMID- 29823649
TI  - New Year's Day 1915.

PMID- 29823651
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823652
TI  - The Metropolitan Asylums Board and Permanent Invalid Children.

PMID- 29823654
TI  - Ambulance Work, the Public, and the National Guard.

PMID- 29823653
TI  - Institutions for Sailors.

PMID- 29823656
TI  - The War and Hospitals for Nervous Diseases.

PMID- 29823655
TI  - Latest Type of German Tuberculosis Pavilions.

PMID- 29823658
TI  - British Wounded in a French Hospital at St. Malo.

PMID- 29823657
TI  - Early-Closing Day at Chemists' Shops.

PMID- 29823659
TI  - With a British Field Ambulance in Retreat.

PMID- 29823660
TI  - Metaphysics and Mental Disease.

PMID- 29823661
TI  - Duty-Free Rectified Spirit in Hospitals: Objections Answered and New Points
      Urged.

PMID- 29823663
TI  - The Institutional Problem of Mental Defectives.

PMID- 29823662
TI  - St. Bartholomew's Hospital and the Wounded: Two Months' Experience of War Work.

PMID- 29823664
TI  - The Recent Heavy Rush of Work at Cambridge.

PMID- 29823665
TI  - The Birmingham Scheme of Classified Institutions: What It Does, and Where It
      Fails.

PMID- 29823667
TI  - Hospital and Institutional News.

PMID- 29823666
TI  - From the Patient's Point of View: A Nurse's Experience as a Patient.

PMID- 29823669
TI  - Work for the Wounded of the Allied Armies.

PMID- 29823668
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823671
TI  - The Medical Research Committee and the War.

PMID- 29823670
TI  - The Iodine Method of Skin Sterilisation: Its Value against Septic Infection.

PMID- 29823673
TI  - Hospital and Institutional News.

PMID- 29823672
TI  - Vacant Appointments: Canvassing or Non-Canvassing for Elections.

PMID- 29823674
TI  - The Halifax Union Poor-Law Hospital.

PMID- 29823676
TI  - Women Doctors and the Present Crisis.

PMID- 29823675
TI  - King Edward's Hospital Fund for London Statistics.

PMID- 29823677
TI  - A Hospital for Soldiers Suffering from Shock: Dr. Edwin Ash's Reply to Lord
      Knutsford.

PMID- 29823678
TI  - Abdominal Caesarean Section for Eclampsia.

PMID- 29823679
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823680
TI  - A Suggested New Flag for Hospitals.

PMID- 29823681
TI  - Taxation and the Voluntary Hospitals.

PMID- 29823683
TI  - Hospitals and the War: Work for the Wounded of the Allied Armies.

PMID- 29823682
TI  - "The War's Effect on a London Eye Hospital".

PMID- 29823685
TI  - Some Provincial Hospital Chapels.

PMID- 29823684
TI  - Mental Stress Associated with Shock: Some Obscure Results of Violence in Peace
      and War.

PMID- 29823686
TI  - War and Disease. II.-The Russo-Japanese and South African Campaigns.

PMID- 29823687
TI  - A Visit to Stockholm Hospitals.

PMID- 29823688
TI  - Discrepancies as to the Number of the Insured.

PMID- 29823689
TI  - The Department of Modern Nursing: VIII. London Homoeopathic Hospital.

PMID- 29823691
TI  - Some Home-Made Hospital Equipment: Examples from Leicester Infirmary: Heating
      Apparatus for Theatre-A Radiant Heat Novelty-Hospital Doors.

PMID- 29823690
TI  - Hospital and Institutional News.

PMID- 29823692
TI  - The Editor's Letter-Box.

PMID- 29823693
TI  - Civil Hospitals and Military Officials.

PMID- 29823694
TI  - Clinical Records in Poor-Law Infirmaries: A Rejoinder.

PMID- 29823695
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823696
TI  - Pharmacopoeial Doses.

PMID- 29823697
TI  - Section 12 of the National Insurance Act : A Year's Experience.

PMID- 29823698
TI  - Damage to Hospitals by Hostile Air-Craft.

PMID- 29823699
TI  - Hospital and Institutional News.

PMID- 29823700
TI  - Erratum: Halifax Union Poor-Law Hospital.
AB  - [This corrects the article on p. 243 in vol. 57.].

PMID- 29823701
TI  - Boots for the Belgian Wounded.

PMID- 29823702
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823703
TI  - Surgical Experiences in the Present War: Modern Bullet Wounds of the Soft Parts.

PMID- 29823704
TI  - Gravesend Hospital and the War: Mr. W. Pearson and Miss Davidson on Its Work.

PMID- 29823705
TI  - Special Hospital for Officers Suffering from Shock-Rejoinder to Dr. Ash.

PMID- 29823706
TI  - The London Panel Committee: An Important Series of Decisions.

PMID- 29823707
TI  - Effects of the War on National Insurance.

PMID- 29823709
TI  - Some General Influences of the War.

PMID- 29823708
TI  - The European War Fund Formed by the St. John Ambulance Department.

PMID- 29823711
TI  - Work for the Wounded of the Allied Armies.

PMID- 29823710
TI  - The New Pharmacopoeia.

PMID- 29823712
TI  - Two Months of War Work at Manchester: The Royal Infirmary's Aid for the Wounded.

PMID- 29823714
TI  - Christmas Day 1914.

PMID- 29823713
TI  - Impressions of a German Hospital: The Eppendorf Hospital in Hamburg.

PMID- 29823716
TI  - A Women's Volunteer Reserve.

PMID- 29823715
TI  - The Need for Young Qualified Medical Men.

PMID- 29823718
TI  - Proposed Women's Voluntary Hospital Brigade.

PMID- 29823717
TI  - Institutional Needs.

PMID- 29823720
TI  - The Hallucinations of Hearing.

PMID- 29823719
TI  - Hospital Account Keeping and the War: The Allocation of War Expenditure.

PMID- 29823721
TI  - Boots for Belgian Wounded : Thanks from Worcester.

PMID- 29823722
TI  - The Department of Modern Nursing: VII. The Middlesex Hospital.

PMID- 29823723
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823725
TI  - Some Influences of the Darkened Streets.

PMID- 29823724
TI  - Bleaching and Disinfecting by the Aid of Electrolysis: Experiments at Bexley
      Mental Hospital.

PMID- 29823727
TI  - Impressions from a Field Ambulance: Tyres, Equipment, and the Health of an Army.

PMID- 29823726
TI  - Art Stamps for Charitable Purposes.

PMID- 29823729
TI  - Legal Notes for Institutional Workers.

PMID- 29823728
TI  - The Involution of the Uterus and Its Influence on Practical Therapy.

PMID- 29823730
TI  - Hospital and Institutional News.

PMID- 29823731
TI  - The Reconstruction of the Metropolitan Asylums Board.

PMID- 29823732
TI  - Practical Points in Hospital Matters: An Improved Type of Motor Ambulance.

PMID- 29823733
TI  - Hospital and Institutional News.

PMID- 29823735
TI  - The Sick and Wounded in War: International Law and Usage.

PMID- 29823734
TI  - The Cost of Christmas Festivities.

PMID- 29823737
TI  - The Rewards of Institutional Life.

PMID- 29823736
TI  - The Hospitals and the Wounded: How to Safeguard Civilian Patients.

PMID- 29823739
TI  - Medical Students and the War.

PMID- 29823738
TI  - Clark's Fluorescent Screen Bullet Localiser.

PMID- 29823740
TI  - Sir Duncombe Mann's Record of Work.

PMID- 29823741
TI  - Hospitals and the War.

PMID- 29823742
TI  - Report of Departmental Committee on Sickness Benefit Claims.

PMID- 29823743
TI  - Bristol General Hospital: The Recent Extension.

PMID- 29823744
TI  - The Action of Chloroform on the Blood.

PMID- 29823745
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823747
TI  - Institutional Needs.

PMID- 29823746
TI  - A New Method of Tuberculin Treatment: The Deycke-Much Programme in Germany.

PMID- 29823749
TI  - Hospital and Institutional News.

PMID- 29823748
TI  - A Visit to Stockholm Hospitals.

PMID- 29823750
TI  - The Professional Life of London: How It Is Reacting to the War.

PMID- 29823751
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823752
TI  - Report of Departmental Committee on Sickness Benefit Claims.

PMID- 29823753
TI  - War and Disease. III.-The Great European War.

PMID- 29823754
TI  - Clinical Value of Poor-Law Infirmaries.

PMID- 29823755
TI  - The Hampstead Appointment.

PMID- 29823756
TI  - Smallpox and Vaccination in Siam: A Remarkable Educational Campaign.

PMID- 29823758
TI  - Rearrangements by the Metropolitan Asylums Board.

PMID- 29823757
TI  - Statistics and Their Critics: King Edward's Hospital Fund for London Statistics
      Fourth Notice.

PMID- 29823759
TI  - The Medical Lessons of the War.

PMID- 29823760
TI  - The Editor's Letter-Box.

PMID- 29823761
TI  - The Editor's Letter-Box.

PMID- 29823762
TI  - Hospital Experience and Higher Appointments.

PMID- 29823763
TI  - Some Provincial Hospital Chapels.

PMID- 29823764
TI  - Ethics of Giving: The Ratio of Generosity to Income.

PMID- 29823766
TI  - The Clinical Value of Poor-Law Infirmaries.

PMID- 29823765
TI  - A New Supply of Leeches: The Medical Aspects of Their Use.

PMID- 29823767
TI  - The Telephone in Medical Practice.

PMID- 29823768
TI  - Hospitals and Charitable Aid in New Zealand: A Glance at State Aid in the
      Colonies.

PMID- 29823769
TI  - Mr. Samuel at the Poor-Law Conference.

PMID- 29823770
TI  - Medical Inventiveness in War: Some Minor Examples of Ingenuity.

PMID- 29823771
TI  - General Hospital, Rangoon.

PMID- 29823772
TI  - Economy in the Generation and Use of Steam: The Condensation of Steam.

PMID- 29823774
TI  - Hospital and Institutional News.

PMID- 29823773
TI  - Legal Notes for Institutional Workers.

PMID- 29823775
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823776
TI  - Deaths under Anaesthetics: The Relation of Coroners and Hospital Staffs.

PMID- 29823777
TI  - By Belgians for Belgians.

PMID- 29823778
TI  - Professional Titles, Pleasant and Unpleasant.

PMID- 29823779
TI  - Sir St. Clair Thomson's Harveian Lecture.

PMID- 29823781
TI  - A Medical Causerie.

PMID- 29823780
TI  - The Evolution of the Modern Hospital: IV. Medical Education, Administration, and
      Finance.

PMID- 29823783
TI  - Home-Made Hospital Equipment: A Cold-Storage Plant at a Provincial Hospital.

PMID- 29823782
TI  - Soldiers at the London Hospital: The Method and Procedure Adopted.

PMID- 29823784
TI  - Hospital and Institutional News.

PMID- 29823785
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823786
TI  - Six Months of Hospital War Work.

PMID- 29823787
TI  - The Division of In-Patient and Out-Patient Expenditure: King Edward's Hospital
      Fund for London Statistics.

PMID- 29823788
TI  - The Belgian Field Hospital from within: The Surgeon-In-Chief's Experiences.

PMID- 29823789
TI  - Sanitary Features of the Present Campaign.

PMID- 29823790
TI  - The French Medical Service: The Organisation through French Eyes.

PMID- 29823791
TI  - Legal Notes for Institutional Workers.

PMID- 29823792
TI  - The Roll of Honour of the Royal College of Surgeons in Ireland.

PMID- 29823793
TI  - Surgical Experiences in the Present War: Anti-Typhoid Inoculation in the Field.

PMID- 29823794
TI  - The War and the Rainfall.

PMID- 29823795
TI  - The War and Medical Teaching.

PMID- 29823796
TI  - Economy in the Generation and Use of Steam: Waste of Heat in the Boiler.

PMID- 29823797
TI  - The Ophthalmic Problem for Hospitals and Doctors.

PMID- 29823798
TI  - India-Rubber Flooring for Hospital Work.

PMID- 29823799
TI  - Some Provincial Hospital Chapels.

PMID- 29823800
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823801
TI  - Hospital Policy during the War.

PMID- 29823802
TI  - The Cost of Hospitals with Medical Schools: King Edward's Hospital Fund for
      London Statistics-Third Notice.

PMID- 29823803
TI  - The Neurological Institute in New York City.

PMID- 29823804
TI  - Hospital and Institutional News.

PMID- 29823805
TI  - War and Disease. I.-Continental Wars of the Nineteenth Century.

PMID- 29823806
TI  - The Clinical Value of Poor-Law Infirmaries: Their Lack of System and Suggested
      Reforms.

PMID- 29823807
TI  - Election of Vice-Chairman and Officers.

PMID- 29823808
TI  - War and the Anti-Tuberculosis Crusade: The Effect of Military Enlistment.

PMID- 29823810
TI  - Three Weeks at a Seaside Convalescent Home.

PMID- 29823809
TI  - Chronic Catarrhal Appendicitis in School Children.

PMID- 29823811
TI  - The Education of Hospital Officers.

PMID- 29823813
TI  - The Clinical Value of Poor-Law Infirmaries.

PMID- 29823812
TI  - Hospital Administrators at the Base Hospitals in South Africa.

PMID- 29823815
TI  - Hospital and Institutional News.

PMID- 29823814
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823816
TI  - Hygienic Conditions at the Crystal Palace: Have Sufficient Precautions Been
      Taken?

PMID- 29823817
TI  - A Gravesend Good Samaritan.

PMID- 29823818
TI  - Military Medical Heroism.

PMID- 29823819
TI  - Open Posts and Poor-Law Volunteers.

PMID- 29823820
TI  - The New Soldiers' Wards at Norwich Hospital: A Suggestive Type for Continued
      Treatment.

PMID- 29823821
TI  - Gunshot Wounds of the Head: The Collective Experience of Surgeons.

PMID- 29823822
TI  - The Department of Modern Nursing: IX. Guy's Hospital: The Preliminary Training
      School.

PMID- 29823823
TI  - The London Panel Committee Meeting.

PMID- 29823824
TI  - Liverpool Royal Infirmary and the Wounded.

PMID- 29823825
TI  - Perth Royal Infirmary.

PMID- 29823826
TI  - St. Columba's Hospital, Home of Peace.

PMID- 29823827
TI  - Urinary Antiseptics.

PMID- 29823828
TI  - Active Service and Medical Officers' Pensions.

PMID- 29823830
TI  - The Department of Modern Nursing: IX: Guy's Hospital: The Preliminary Training
      School.

PMID- 29823829
TI  - Hospital and Institutional News.

PMID- 29823831
TI  - Traumatic Neurasthenia and Mental Disease: The Need for More Precise Definition.

PMID- 29823832
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823833
TI  - The London School of Medicine for Women.

PMID- 29823834
TI  - Stewart's Bedding.

PMID- 29823835
TI  - The Education of the Hospital Officer: Examinations and a Three Years' Course.

PMID- 29823836
TI  - With the Burgher Commandoes in South Africa: My Medical Experiences in the
      Campaign.

PMID- 29823837
TI  - The Evolution of the Modern Hospital: III. The New Epoch in Equipment and
      Expense.

PMID- 29823839
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823838
TI  - The Chapel of St. Luke the Physician, Camberwell House.

PMID- 29823841
TI  - Guardians and the Demand for Nurses.

PMID- 29823840
TI  - Hospitals and Payment for Wounded.

PMID- 29823843
TI  - Massage and Mechano-Therapeutics at the Front: The Importance of Hastening
      Convalescence.

PMID- 29823842
TI  - Hospital and Institutional News.

PMID- 29823844
TI  - School Medical Inspection and the War: The Part of the Medical Inspector.

PMID- 29823845
TI  - The New Amendment Act.

PMID- 29823846
TI  - The Evolution of the Modern Hospital: IV. Medical Education, Administration, and
      Finance.

PMID- 29823847
TI  - Restricting Admissions to Poor-Law Infirmaries.

PMID- 29823848
TI  - London Panel Committee.

PMID- 29823849
TI  - The Contract System in War-Time: How It Is Working and the Future Outlook.

PMID- 29823850
TI  - Institutional Needs.

PMID- 29823851
TI  - The Case for Day Nurseries.

PMID- 29823852
TI  - The Medical Work of the Education Department.

PMID- 29823854
TI  - King Edward VII.'s Hospital, Cardiff.

PMID- 29823853
TI  - The Army and the Medical Profession.

PMID- 29823855
TI  - The Education of Hospital Officers.

PMID- 29823856
TI  - The Editor's Letter-Box.

PMID- 29823857
TI  - The Investigation of England's Vitality: Actual Results of Public Health Work.

PMID- 29823858
TI  - A Medical Causerie.

PMID- 29823859
TI  - The Royal College of Surgeons Ward.

PMID- 29823860
TI  - Hospital and Institutional News.

PMID- 29823861
TI  - The Work of Radium Institutes: The Cases Received and the Results of Treatment.

PMID- 29823862
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823863
TI  - Points in the Quarterly Report.

PMID- 29823864
TI  - St. George's Hospital and the Wounded.

PMID- 29823865
TI  - The Public Relations of Post-Mortem Examinations.

PMID- 29823866
TI  - The Clinical Value of Poor-Law Infirmaries.

PMID- 29823867
TI  - A Debate on Cerebro-Spinal Meningitis: The Problems of Military Epidemics.

PMID- 29823869
TI  - Institutional Pharmacists and the "B.P."

PMID- 29823868
TI  - The Evolution of the Modern Hospital: II. The Nightingale School and a New Epoch.

PMID- 29823871
TI  - The Electro-Cardiograph: Laboratory Findings and Clinical Applications.

PMID- 29823870
TI  - Institutional Needs.

PMID- 29823872
TI  - Leicester as a Hospital Town: The Problem of Extended Accommodation.

PMID- 29823874
TI  - What Is "Ophthalmic Medicine"?

PMID- 29823873
TI  - The Values of Stocks at Given Times: King Edward's Hospital Fund for London
      Statistics.-Fifth Notice.

PMID- 29823876
TI  - The King at Cambridge.

PMID- 29823875
TI  - The Clinical Value of Poor-Law Infirmaries: The Root of the Medical Difficulty.

PMID- 29823877
TI  - The Pharmaceutical Society.

PMID- 29823878
TI  - Resident Appointments and the Present Emergency.

PMID- 29823879
TI  - The Editor's Letter-Box.

PMID- 29823880
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823881
TI  - Hospital and Institutional News.

PMID- 29823882
TI  - The Telephone in Medical Practice.

PMID- 29823883
TI  - Medical Gymnastics and Massage.

PMID- 29823884
TI  - A Township for the Blind.

PMID- 29823885
TI  - The Editor's Letter-Box.

PMID- 29823886
TI  - The Paddington Infirmary System.

PMID- 29823887
TI  - The Bombardment of Coast Towns: Brighton's Medical Emergency Scheme.

PMID- 29823889
TI  - St. George's Hospital.

PMID- 29823890
TI  - Ancoats Hospital and the War.

PMID- 29823888
TI  - The Clinical Value of Poor-Law Infirmaries.

PMID- 29823891
TI  - Royal Infirmary, Liverpool.

PMID- 29823893
TI  - The American Women's War Hospital.

PMID- 29823892
TI  - Medico-Social Questions and the War: The Profession and the Politicians.

PMID- 29823894
TI  - A Medical Causerie.

PMID- 29823895
TI  - The Evolution of the Modern Hospital: I. The Internal Revolution.

PMID- 29823896
TI  - Some Medical Lessons of the War: The Control of Camp Diseases.

PMID- 29823897
TI  - The Statistical Report for 1914.

PMID- 29823898
TI  - The Home Production of Food.

PMID- 29823899
TI  - Nurses' Accommodation at Glasgow Hospitals: An Educative Contrast and a
      Revelation.

PMID- 29823900
TI  - A Medical Causerie.

PMID- 29823901
TI  - Phthisis in the Boot and Shoe Industry: Medical Research Committee (First
      Report).

PMID- 29823902
TI  - A British Hospital at Limoges.

PMID- 29823904
TI  - Hospital and Institutional News.

PMID- 29823905
TI  - Hughlings Jackson.

PMID- 29823903
TI  - Parliament and the Profession.

PMID- 29823906
TI  - The Blind Soldier.

PMID- 29823907
TI  - Unqualified Practice.

PMID- 29823908
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823909
TI  - The British Hospitals Association: Mr. Wade Deacon's Address.

PMID- 29823910
TI  - The D.C.M. for Field Ambulance Men.

PMID- 29823911
TI  - Instruction in Medical Ethics.

PMID- 29823912
TI  - Emergency Military Hospital Construction.

PMID- 29823913
TI  - St. Bartholomew's Hospital: Precautions against Air Raids.

PMID- 29823914
TI  - A "Revolt" of Sanatorium Patients.

PMID- 29823915
TI  - Almeric Paget Massage Corps.

PMID- 29823916
TI  - The Use of Abbreviations in Prescribing.

PMID- 29823918
TI  - Hospital and Institutional News.

PMID- 29823917
TI  - Effects of the Increase in Employment of Women.

PMID- 29823919
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823920
TI  - The Strain on the Institutions.

PMID- 29823922
TI  - How the R.A.M.C. Saves Combatant Wastage.

PMID- 29823921
TI  - Patriotism and the Nurse-Training Schools: IV. Some London Poor-Law Infirmaries.

PMID- 29823923
TI  - Royal Victoria and West Hants Hospital.

PMID- 29823924
TI  - The Right to Change Your Doctor.

PMID- 29823925
TI  - Parliament and the Profession.

PMID- 29823926
TI  - Hospitals and the Poets.-II. The Medical Career of Oliver Goldsmith.

PMID- 29823927
TI  - Credulity and Credibility: By a Medical Officer from France.

PMID- 29823928
TI  - Textile Supplies for Hospitals: III. The Raw Materials: Cotton and Linen.

PMID- 29823930
TI  - The National Relief Fund in Scotland.

PMID- 29823929
TI  - Hospital and Institutional News.

PMID- 29823931
TI  - Parliament and the Profession.

PMID- 29823932
TI  - Poisons and Poisoning: Some Legal Difficulties Explained.

PMID- 29823933
TI  - Patriotism and the Nurse-Training Schools: VI. Guy's Hospital.

PMID- 29823934
TI  - Honours and the Nursing Profession.

PMID- 29823935
TI  - Clinical Tests of New Drugs.

PMID- 29823936
TI  - Robbing the Hospitals.

PMID- 29823937
TI  - A Great Extension Scheme at Cardiff: Colonel Bruce Vaughan's Enterprise and
      Success.

PMID- 29823938
TI  - Appeal and Accountancy Methods Examined.

PMID- 29823939
TI  - Allen and Hanburys' Bicentenary.

PMID- 29823940
TI  - Junior Students and Recruiting.

PMID- 29823941
TI  - An Extraordinary Case at Bradford.

PMID- 29823943
TI  - The London County Council.

PMID- 29823942
TI  - The Army and Territorial Nurses' Cape.

PMID- 29823944
TI  - The Medical Schools of British Hospitals: St. Bartholomew's Medical School.

PMID- 29823945
TI  - Legal Notes for Pharmacists.

PMID- 29823946
TI  - A Medical Causerie.

PMID- 29823947
TI  - Education in the Transvaal: Mr. C. Louis Leipoldt's Report as Medical Inspector.

PMID- 29823948
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823949
TI  - The Editor's Letter-Box.

PMID- 29823950
TI  - King George's Bed.

PMID- 29823951
TI  - Hospital and Institutional News.

PMID- 29823952
TI  - The Irish Matrons' Association and the Martyr Nurse.

PMID- 29823953
TI  - Chelsea Hospital for Women.

PMID- 29823954
TI  - The Royal Infirmary, Glasgow.

PMID- 29823955
TI  - About Rheumatism.

PMID- 29823956
TI  - Women Doctors after the War.

PMID- 29823957
TI  - Parliament and the Profession.

PMID- 29823958
TI  - Hospital and Institutional News.

PMID- 29823959
TI  - The Treatment of Naevi.

PMID- 29823960
TI  - Parliament and the Profession.

PMID- 29823961
TI  - Edith Cavell Home for Nurses: London Hospital.

PMID- 29823962
TI  - Mothercraft and Child-Welfare Centres: II. Difficulties and Problems.

PMID- 29823963
TI  - A Medical Causerie.

PMID- 29823964
TI  - The Profession and Titular Distinctions.

PMID- 29823965
TI  - Our Voluntary Hospitals: Some General Effects of the War.

PMID- 29823966
TI  - The Engineer's Department at Guy's Hospital.

PMID- 29823967
TI  - Round the World.

PMID- 29823968
TI  - The Royal Infirmary, Edinburgh.

PMID- 29823970
TI  - The Whistling Nuisance.

PMID- 29823969
TI  - The New King's College Hospital at Denmark Hill.

PMID- 29823971
TI  - A College of Nursing.

PMID- 29823973
TI  - The Enteric Fevers in the War: A Triumph of Scientific Medicine.

PMID- 29823972
TI  - An Important Military Research: The Control of Bilharzia Disease.

PMID- 29823974
TI  - The Women's Maternity Unit for Russia.

PMID- 29823975
TI  - Institutional Needs.

PMID- 29823976
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29823978
TI  - Making the Unfit into Serviceable Recruits.

PMID- 29823977
TI  - Robbing the Hospitals: The Homoeopathic Hospital Case.

PMID- 29823979
TI  - Hospital and Institutional News.

PMID- 29823980
TI  - A Medical Causerie.

PMID- 29823981
TI  - Parliament and the Profession.

PMID- 29823982
TI  - The Western Hospital, Torquay.

PMID- 29823983
TI  - Possible Changes of the Future.

PMID- 29823984
TI  - Research at the Seat of War: The Combating of Wound Infections.

PMID- 29823985
TI  - Abnormal Times and Their Burdens.

PMID- 29823986
TI  - Coventry and Warwickshire Hospital.

PMID- 29823987
TI  - Honours and the Nursing Profession.

PMID- 29823988
TI  - Rules as to Behaviour during Sickness.

PMID- 29823989
TI  - The Termination of Honorary Staff Appointments.

PMID- 29823990
TI  - Voluntary Work for Military Hospitals: A Bournemouth Workshop.

PMID- 29823991
TI  - The Supply of Medical Students.

PMID- 29823993
TI  - The Settlement of Disputes.

PMID- 29823992
TI  - Legal Notes for Institutional Workers.

PMID- 29823994
TI  - Samaritan Free Hospital for Women.

PMID- 29823995
TI  - American Ideals and Hospital Efficiency: Looking Forward.

PMID- 29823997
TI  - The Hospital System of India.

PMID- 29823996
TI  - The Regimental Medical Officer: An Outline of His Duties.

PMID- 29823998
TI  - Something New in Medicine.

PMID- 29823999
TI  - A Medical Causerie.

PMID- 29824000
TI  - Mothercraft and Child-Welfare Centres: I. How to Manage Schools for Mothers.

PMID- 29824001
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824002
TI  - Hospital and Institutional News.

PMID- 29824003
TI  - The Work of the R.A.M.C.: Another Record of Gallant Deeds.

PMID- 29824004
TI  - Parliament and the Profession.

PMID- 29824005
TI  - Uniform Compliments Invite Criticism on Dublin Hospitals.

PMID- 29824006
TI  - Modern Tendencies in Hospital Administration.

PMID- 29824007
TI  - Hospitals and the Conversion of Consols: Pros and Cons by a Secretary.

PMID- 29824008
TI  - Voluntary Hospitals and Local Health Authorities: What University College
      Hospital Is Doing.

PMID- 29824009
TI  - The Hospital for Sick Children.

PMID- 29824011
TI  - The Value of Percussion.

PMID- 29824010
TI  - Efficient Care Committees.

PMID- 29824012
TI  - Acute Nephritis in the Army: A Curious Outbreak in Flanders.

PMID- 29824013
TI  - Professional and Popular Freedom.

PMID- 29824014
TI  - How to Prepare an Annual Report: A Secretary Gives His View.

PMID- 29824015
TI  - Middlesex Hospital Medical School.

PMID- 29824016
TI  - Institutional Needs.

PMID- 29824017
TI  - Parliament and the Profession.

PMID- 29824018
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824020
TI  - Mind Blindness and Visual Memories: How the Brain Works: The Exceptional Child.

PMID- 29824019
TI  - The Population Problem.

PMID- 29824021
TI  - Hospital and Institutional News.

PMID- 29824022
TI  - The Medical Profession and the New Taxes.

PMID- 29824023
TI  - How the Germans Treat Wounded Prisoners: The Testimony of a French Doctor.

PMID- 29824024
TI  - Passing Topics of the Day.

PMID- 29824026
TI  - The Royal Hospital for Sick Children, Glasgow.

PMID- 29824025
TI  - A Clinical Pilgrimage in War Time: The Children's Hospitals of Europe.

PMID- 29824027
TI  - Some Comparisons between London and Liverpool.

PMID- 29824029
TI  - Doctors and the War.

PMID- 29824028
TI  - Our Limbless Sailors and Soldiers: An Appeal.

PMID- 29824030
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824031
TI  - Hospital and Institutional News.

PMID- 29824032
TI  - The Distribution of Medical Officers in the Expeditionary Force.

PMID- 29824033
TI  - The Current Week's Proceedings.

PMID- 29824035
TI  - A Reminiscence of 1914: Christmas Morning with an Ambulance.

PMID- 29824034
TI  - The Living and Dead Hands.

PMID- 29824037
TI  - Meeting of the Governors and General Council.

PMID- 29824036
TI  - Kitchen and Stores Department: "Tip and Non-Tip" Kitchen Boilers.

PMID- 29824039
TI  - Hospital Cost and Hospital Statistics.

PMID- 29824038
TI  - The League of Mercy: Annual Meeting at St. James's Palace.

PMID- 29824040
TI  - Hospital Administration in War-Time.

PMID- 29824041
TI  - King Edward's Hospital Fund for London: The Distribution Committee's Report.

PMID- 29824042
TI  - Annual Meeting of Constituents.

PMID- 29824043
TI  - Sir Ernest Cassel's Further Gifts to Hospitals.

PMID- 29824044
TI  - Hospital and Institutional News.

PMID- 29824045
TI  - What Should They Publish about Their Work and Needs?

PMID- 29824047
TI  - The Medical Examination of Recruits.

PMID- 29824046
TI  - A Talk about Voluntary Hospitals.

PMID- 29824048
TI  - What Should They Publish about Their Work and Needs?

PMID- 29824049
TI  - Cost of London and Glasgow Hospitals Compared.

PMID- 29824050
TI  - The Nation's Awakening: An Opportunity for the Churches.

PMID- 29824051
TI  - Christmas with the Wounded and Sick.

PMID- 29824052
TI  - Entertainments in Hospitals.

PMID- 29824053
TI  - Round the London Hospitals.

PMID- 29824054
TI  - Christmas Day at Guy's Hospital: A Wonderful Atmosphere of Unselfish Effort.

PMID- 29824055
TI  - Some Military and Provincial Hospitals.

PMID- 29824056
TI  - Institutional Needs.

PMID- 29824058
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824057
TI  - Manchester and the Wounded.

PMID- 29824059
TI  - Hospital and Institutional News.

PMID- 29824060
TI  - Christmas in the Hospitals: England's Greeting.

PMID- 29824061
TI  - Parliament and the Profession.

PMID- 29824062
TI  - Hospital Equipment in War-Time.

PMID- 29824063
TI  - Bristol Royal Infirmary.

PMID- 29824064
TI  - Round the World.

PMID- 29824065
TI  - The Numbers of Practitioners and Students.

PMID- 29824066
TI  - Matrons and Sisters.

PMID- 29824067
TI  - Textile Supplies for Hospitals: IV. The Animal Fibres.

PMID- 29824068
TI  - The Will to Recover: Its Victories and Limitations.

PMID- 29824069
TI  - Hospital and Institutional News.

PMID- 29824070
TI  - "The Greatest Sin against Our Country".

PMID- 29824072
TI  - Tobacco and the Soldier: The Medico-Military Problem.

PMID- 29824071
TI  - Parliament and the Profession.

PMID- 29824073
TI  - The Medical Examination of Recruits: An Effort to Amend the Muddle.

PMID- 29824074
TI  - Hospitals and the Poets.-III. Keats' Seven Years of Medicine.

PMID- 29824075
TI  - Round the Hospitals.

PMID- 29824076
TI  - Parliament and the Profession.

PMID- 29824078
TI  - Cubic Air Space for Institutional Infants.

PMID- 29824077
TI  - Hospital and Institutional News.

PMID- 29824080
TI  - The War and Voluntary Hospital Beds: Military Convalescents v. Urgent Cases.

PMID- 29824079
TI  - The Army and Territorial Nurses' Cape.

PMID- 29824081
TI  - Rheumatism in Its Professional and Popular Aspects.

PMID- 29824082
TI  - Patriotism and the Nurse-Training Schools: II. The London Hospital.

PMID- 29824084
TI  - The Grievances of Poor-Law Medical Officers.

PMID- 29824083
TI  - A Medical Causerie.

PMID- 29824085
TI  - Institutional Needs.

PMID- 29824086
TI  - Heroism in Hospital Workers.

PMID- 29824087
TI  - Some Problems Which Press.

PMID- 29824088
TI  - Under the Red Cross: A Record of Wonderful Achievements.

PMID- 29824090
TI  - Some Military Medical Economies: The Value of Criticism.

PMID- 29824089
TI  - Medical Service during War and Peace.

PMID- 29824091
TI  - A Medical Causerie.

PMID- 29824092
TI  - Professional Handwriting.

PMID- 29824093
TI  - Matrons and Sisters.

PMID- 29824094
TI  - The Florence Nightingale Memorial.

PMID- 29824096
TI  - Recent Attacks on the Uniform System: Some Criticisms and Suggestions.

PMID- 29824095
TI  - How to Obtain Laundry Hands.

PMID- 29824097
TI  - Legal Notes for Institutional Workers.

PMID- 29824099
TI  - Domestic Economy in the Isolation Hospital: An Example of Prudent Housekeeping.

PMID- 29824098
TI  - Reports on Hospitals of the United Kingdom: The New Hospital Wards at Newcastle
      Union Workhouse.

PMID- 29824100
TI  - Hospital and Institutional News.

PMID- 29824101
TI  - Some Nursing Developments.

PMID- 29824102
TI  - Medical Papers in Public Libraries.

PMID- 29824103
TI  - How to Buy Textiles Cheaply.

PMID- 29824104
TI  - Ambulance Detachment on Duty Every Night at St. Bartholomew's Hospital.

PMID- 29824105
TI  - Hospital and Institutional News.

PMID- 29824106
TI  - The Real King Edward the VIIth: Lord Redesdale's Experiences.

PMID- 29824107
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824108
TI  - Patriotism and the Nurse-Training Schools: V. Some Provincial Poor-Law
      Infirmaries.

PMID- 29824109
TI  - Institutional Needs.

PMID- 29824111
TI  - Memorials to Nurse Cavell.

PMID- 29824110
TI  - The Population Problem: The Importance of Maternal Mortality as a Factor.

PMID- 29824113
TI  - Parliament and the Profession.

PMID- 29824112
TI  - Hospital Meetings.

PMID- 29824115
TI  - Childbed Mortality.

PMID- 29824114
TI  - A Lay Journal on Medical Education.

PMID- 29824117
TI  - Royal College of Surgeons: Annual Meeting.

PMID- 29824116
TI  - Hospital Weakness and Hospital Strength: When the Voluntary Hospital Triumphs.

PMID- 29824118
TI  - The New Medical Benefit Regulations.

PMID- 29824119
TI  - "Frost-Bite" in the Trenches.

PMID- 29824121
TI  - Hospital and Institutional News.

PMID- 29824120
TI  - The Statistical Report for 1914.

PMID- 29824123
TI  - Parliament and the Profession.

PMID- 29824122
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824124
TI  - The Examination of Fatigued Children.

PMID- 29824126
TI  - Institutional Needs.

PMID- 29824125
TI  - The 3rd London General Hospital.

PMID- 29824127
TI  - The Practitioner and the Professional Soldier: Their Relations in the R.A.M.C.

PMID- 29824128
TI  - Military and Medical Recruiting.

PMID- 29824129
TI  - Eye-Strain as a Cause of Disease: Factors in Successful Treatment.

PMID- 29824130
TI  - Personal Service in Leicester: Some Fruits of War-Time.

PMID- 29824131
TI  - Patriotism and the Nurse-Training Schools: III. A Group of North-Country
      Hospitals.

PMID- 29824132
TI  - Should Pyrexia Be Treated?

PMID- 29824133
TI  - Another Raid on the Civil Hospitals.

PMID- 29824134
TI  - Tetanus in War: Value of the Serum Treatment.

PMID- 29824135
TI  - The Training of Memory.

PMID- 29824136
TI  - A Glance at Some Contemporaries.

PMID- 29824138
TI  - The Manchester Royal Infirmary.

PMID- 29824137
TI  - Hospital Economy in War-Time.

PMID- 29824139
TI  - The Vacant Secretaryship at Norwich: Hundreds of Applications or None?

PMID- 29824140
TI  - The "Massage Establishments" Scandal: Lords' Select Committee's Inquiry and
      Decision.

PMID- 29824141
TI  - The Editor's Letter-Box.

PMID- 29824143
TI  - Hospital and Institutional News.

PMID- 29824142
TI  - Hospital Saturday, 1915.

PMID- 29824144
TI  - War Equipment.

PMID- 29824145
TI  - The Regimental Stretcher-Bearers: Their Heroism and Grit.

PMID- 29824147
TI  - Some General Effects of War Upon the Voluntary Hospitals.

PMID- 29824146
TI  - Hospital Barges for the Wounded.

PMID- 29824148
TI  - Pubiotomy, Caesarean Section, and Induction.

PMID- 29824149
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824150
TI  - Hospitals and the Poets.- The Poet Laureate, Henley, and Two Famous Hospitals.

PMID- 29824151
TI  - Hospital and Institutional News.

PMID- 29824153
TI  - A Revival in Antiseptics: Two Interesting Papers.

PMID- 29824152
TI  - The Treatment of Wounds Controversy.

PMID- 29824155
TI  - Round the World.

PMID- 29824154
TI  - Textile Supplies for Hospitals: II. The Basis of Values.

PMID- 29824156
TI  - The Tubercular Patients Problem.

PMID- 29824157
TI  - The Vanquishing of Ophthalmia: A Crusade against One of the Plagues of Egypt.

PMID- 29824158
TI  - The Treatment of Abdominal Wounds: The Contrasts of Two Campaigns.

PMID- 29824159
TI  - The Finance of a Year's Red Cross Work: The Administration of Two Millions of
      Money.

PMID- 29824160
TI  - St. Mary's Hospital for Women and Children, Plaistow.

PMID- 29824161
TI  - A General Survey of Developments during the Year 1915.

PMID- 29824163
TI  - Errata.
AB  - [This corrects the article on p. 301 in vol. 59.].

PMID- 29824162
TI  - Parliament and the Profession.

PMID- 29824165
TI  - Hours of Work for Women: Night Work for Nurses and Munition Workers.

PMID- 29824164
TI  - The Prevention of Venereal Diseases: The Report of the Royal Commission.

PMID- 29824166
TI  - To the R.N. Division.

PMID- 29824167
TI  - The Canonisation of Research.

PMID- 29824168
TI  - A Nursing Mess and Its Teaching.

PMID- 29824169
TI  - The Price of Gas.

PMID- 29824170
TI  - Where a Nursing Sister Was Not Even a Nurse.

PMID- 29824171
TI  - A Word of Caution to Hospital Buyers: Have Drugs Passed Their Highest Price?

PMID- 29824172
TI  - Parliament and the Profession.

PMID- 29824173
TI  - The Pressure on the Profession.

PMID- 29824174
TI  - War Wastage.

PMID- 29824175
TI  - A Medical Causerie.

PMID- 29824176
TI  - Hospital and Institutional News.

PMID- 29824177
TI  - Trench Fever: A Diagnostic Dumping Ground?

PMID- 29824179
TI  - Institutional Needs.

PMID- 29824178
TI  - Round the Hospitals.

PMID- 29824180
TI  - St. Marylebone Health Society.

PMID- 29824181
TI  - Exclusions.

PMID- 29824182
TI  - The Judge's Summing-Up.

PMID- 29824184
TI  - Is Goitre an Infective Disease?: A Revolutionary Hypothesis and Its Consequences.

PMID- 29824183
TI  - Cancer and the Scientific Spirit.

PMID- 29824185
TI  - Mortuaries: Their Equipment and Management.

PMID- 29824186
TI  - Secret Terms in Physicians' Prescriptions.

PMID- 29824188
TI  - Hospitals and the Poets. VI. Walt Whitman as a Hospital Orderly.

PMID- 29824187
TI  - A Famous Foundling Hospital: Vospitatel'nie Dom, Moscow.

PMID- 29824189
TI  - Hospitals and the Spirit Tax.

PMID- 29824190
TI  - Before Mr. Justice Ridley and a Special Jury.

PMID- 29824191
TI  - Parliament and the Profession.

PMID- 29824192
TI  - The "Dreadnought" Hospital. A Successful and Busy Year.

PMID- 29824193
TI  - Hospital and Institutional News.

PMID- 29824194
TI  - Round the Hospitals.

PMID- 29824195
TI  - Textile Supplies for Hospitals: VII. Wool Clothing.

PMID- 29824196
TI  - The Meaning of "Infectious".

PMID- 29824198
TI  - Parliament and the Profession.

PMID- 29824197
TI  - Poor-Law Infirmaries in War-Time: How Difficulties Have Been Surmounted.

PMID- 29824200
TI  - Hospital and Institutional News.

PMID- 29824199
TI  - The Third London General Hospital, Wandsworth Common, S.W.

PMID- 29824201
TI  - The Universities and Medicine.

PMID- 29824202
TI  - Administrative and Medical Staff.

PMID- 29824203
TI  - Patriotism and the Nurse-Training Schools: I. Examples in Great Britain and
      Ireland.

PMID- 29824204
TI  - The Temporary War Hospital Attached to the General Hospital, Nottingham.

PMID- 29824205
TI  - The Nursing System: Some Difficulties and Differences.

PMID- 29824206
TI  - Some General Effects of War Upon the Voluntary Hospitals.

PMID- 29824207
TI  - Some Plans, Practical and Otherwise.

PMID- 29824208
TI  - The Red Cross and St. John's Organisation: The Joint Societies' Varied Field.

PMID- 29824210
TI  - Poor-Law Buildings and Military Hospitals.

PMID- 29824209
TI  - War Influences on Medical Staffs and the Profession.

PMID- 29824211
TI  - Hospital Provision: Its Difficulties and Limitations.

PMID- 29824213
TI  - The Fifth Northern General Hospital, Leicester: The Recent Additions.

PMID- 29824212
TI  - The Treatment of Wounds Controversy.

PMID- 29824214
TI  - Hospital and Institutional News.

PMID- 29824215
TI  - St. Bartholomew's Hospital Action.

PMID- 29824216
TI  - Florence Nightingale, O.M.: The Memorial Service at St. Paul's Cathedral.

PMID- 29824217
TI  - Textile Supplies for Hospitals: V. The Methods of Manufacture.

PMID- 29824218
TI  - Margarine versus Butter.

PMID- 29824219
TI  - A Matron's Problem.

PMID- 29824220
TI  - The Treatment of Disabled Soldiers.

PMID- 29824221
TI  - Royal Mineral Water Hospital, Bath.

PMID- 29824223
TI  - The Incorporated Society of Trained Masseuses.

PMID- 29824222
TI  - South London Hospital for Women.

PMID- 29824224
TI  - A Medical Aspect of War Wastage.

PMID- 29824225
TI  - Round the Hospitals.

PMID- 29824226
TI  - Nurses Not in the Lime Light.

PMID- 29824227
TI  - How Not to Seek Promotion.

PMID- 29824229
TI  - Food Economy in Institutions: How to Prepare a Menu.

PMID- 29824228
TI  - Form of Service Used at the Unveiling by Her Majesty the Queen of the Memorial to
      Miss Florence Nightingale, O.M.: St. Paul's Cathedral, February 14, 1916, at 2:15
      p.m.

PMID- 29824230
TI  - Hospitals and the Poets.-IV.Crabbe, Akenside, and Armstrong.

PMID- 29824231
TI  - Are Assistant Matrons Unbusinesslike?

PMID- 29824232
TI  - The Law in Institutional Practice: An Important Pronouncement.

PMID- 29824233
TI  - Infectious Disease and Its Notification.

PMID- 29824234
TI  - Medical Papers in Public Libraries.

PMID- 29824235
TI  - An Appeal for L200,000.

PMID- 29824237
TI  - Textile Supplies for Hospitals: VI. Hospital Blankets.

PMID- 29824236
TI  - The Analogy between the Legal and Nursing Professions.

PMID- 29824238
TI  - Schools of Massage: National Hospital for the Paralysed and Epileptic.

PMID- 29824239
TI  - Hospital and Institutional News.

PMID- 29824240
TI  - Vaccines for the Allied Armies: The Inoculation Department at St. Mary's
      Hospital.

PMID- 29824241
TI  - Traumatic Neurasthenia: The Borderline of Malingering.

PMID- 29824242
TI  - Hospitals and the Poets.-V. Dr. Erasmus Darwin, Scientist, Physician, and Poet.

PMID- 29824243
TI  - The Middlesex Hospital.

PMID- 29824244
TI  - Domestic Economy in Isolation Hospitals.

PMID- 29824246
TI  - The Florence Nightingale Memorial.

PMID- 29824245
TI  - The Inherent Statistical Difference of Particular Hospitals.

PMID- 29824247
TI  - Round the Hospitals.

PMID- 29824248
TI  - The Influence of Evidence in Medical Practice.

PMID- 29824250
TI  - The Cancer Problem.

PMID- 29824249
TI  - Parliament and the Profession.

PMID- 29824252
TI  - The London Hospital.

PMID- 29824251
TI  - Lincoln County Hospital.

PMID- 29824253
TI  - The Record of the Arnold Hospital, Doncaster.

PMID- 29824254
TI  - The Population Problem.

PMID- 29824256
TI  - Work and Economy in War-Time: How to Secure Both by Co-Operation.

PMID- 29824255
TI  - The Hospital's Example in War-Time: A More Excellent Way.

PMID- 29824257
TI  - Some Older London Hospitals: How They Have Been Re-Created.

PMID- 29824258
TI  - Hospital and Institutional News.

PMID- 29824260
TI  - War Disadvantages at King's College Hospital.

PMID- 29824259
TI  - Hospital Needs and Hospital Appeals.

PMID- 29824262
TI  - Our Voluntary Hospitals and Institutions.

PMID- 29824261
TI  - Set Your Shoulder at the Wheel, to Advance the Business.

PMID- 29824263
TI  - A War Hospital Supply Depot.

PMID- 29824264
TI  - Every Hospital's Own Gazette: A Great Success at the Military Hospitals.

PMID- 29824265
TI  - A Layman's Account of a Ward's Equipment: What He Found at University College
      Hospital.

PMID- 29824266
TI  - Lord Derby's Grand Effort: The Medical Profession and Recruiting.

PMID- 29824267
TI  - The New King's College Hospital, London.

PMID- 29824268
TI  - Patriotism and Personal Service: How the Giving Public Were Recruited.

PMID- 29824269
TI  - Educational Value of Mr. Pite's Creation.

PMID- 29824270
TI  - Remember Absent Friends.

PMID- 29824271
TI  - Textile Supplies for Hospitals: Chapter I. With Subjects Still to Be Dealt with.

PMID- 29824272
TI  - Round the Hospitals.

PMID- 29824273
TI  - A Good Deodoriser.

PMID- 29824274
TI  - The Claim of the Doctor.

PMID- 29824275
TI  - The War's Effect on a Special Hospital: Phenomenal Increase in the Cost of
      Treatment.

PMID- 29824276
TI  - Carbolic-Acid Poisoning: An Experimental Investigation.

PMID- 29824277
TI  - Praise and Blame.

PMID- 29824278
TI  - The Unconscious Mental Life of the Child: Platform of Child Study Society.

PMID- 29824279
TI  - Research and Remedies.

PMID- 29824281
TI  - Schools of Massage.-II. St. Thomas's Hospital Physical Exercises and Massage
      School.

PMID- 29824280
TI  - Parliament and the Profession.

PMID- 29824283
TI  - Hospital and Institutional News.

PMID- 29824282
TI  - Linen Leagues for Hospitals: Their Growing Activities and Value.

PMID- 29824284
TI  - A Medical Causerie.

PMID- 29824285
TI  - Legal Notes for Institutional Workers.

PMID- 29824286
TI  - Patriotism and the Nurse-Training Schools: VII. A Typical Instance of Good
      Organisation.

PMID- 29824287
TI  - Twenty Years' Experience and Results.

PMID- 29824289
TI  - The War Office and the Poor-Law Infirmary: Military and Civilian Standards.

PMID- 29824288
TI  - Empire Hospital for Paying Patients, Vincent Square, S.W.

PMID- 29824291
TI  - Medical Papers in Public Libraries.

PMID- 29824290
TI  - A Committee of Inquiry Appointed.

PMID- 29824292
TI  - Florence Nightingale and the War.

PMID- 29824294
TI  - The Future of Medical Education.

PMID- 29824293
TI  - The Hospitalisation of the Asylum.

PMID- 29824296
TI  - The Institutional Treatment of Venereal Disease: Isolation and Other Knotty
      Problems.

PMID- 29824295
TI  - The Uniform System of Accounts.

PMID- 29824298
TI  - A Medical Causerie.

PMID- 29824297
TI  - Rat Extermination in Institutions.

PMID- 29824299
TI  - Objections and Difficulties.

PMID- 29824300
TI  - The New Wards at Newcastle Union.

PMID- 29824301
TI  - Round the Hospitals.

PMID- 29824302
TI  - Domestic Economy in the Isolation Hospital.

PMID- 29824303
TI  - Is State Recognition in Sight?

PMID- 29824304
TI  - How to Sell Waste Paper.

PMID- 29824305
TI  - The Pharmaceutical Society and the Sale of Laudanum.

PMID- 29824306
TI  - Colonel Bruce Vaughan's Assured Victory.

PMID- 29824308
TI  - St. Mary's Hospital Medical School.

PMID- 29824307
TI  - Training in Surgical Efficiency: An Original College of Surgery.

PMID- 29824309
TI  - Parliament and the Profession.

PMID- 29824310
TI  - Hospital and Institutional News.

PMID- 29824311
TI  - Female Nurses in the Male Wards of Mental Hospitals in Scotland.

PMID- 29824312
TI  - Hospital and Institutional News.

PMID- 29824313
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824315
TI  - Hospitals V. School Clinics.

PMID- 29824314
TI  - Adelaide Hospital, South Australia.

PMID- 29824316
TI  - The Royal Society of Medicine.

PMID- 29824317
TI  - Payments to Hospitals by Insured In-Patients without Dependants.

PMID- 29824318
TI  - The Limitations of Medical Opinion.

PMID- 29824319
TI  - Case Notes of an Obscure Disease.

PMID- 29824320
TI  - The Work of the R.A.M.C.: Another Record of Gallant Deeds.

PMID- 29824321
TI  - History of Case 2.

PMID- 29824322
TI  - The War and Infant Welfare.

PMID- 29824323
TI  - Institutional Needs.

PMID- 29824324
TI  - The Insurance Act Drug Tariff: Drastic Changes Proposed.

PMID- 29824325
TI  - A Medical Causerie.

PMID- 29824326
TI  - Royal Hospital for Sick Children, Glasgow.

PMID- 29824327
TI  - R.M.O. and the War Office: Something Wrong Somewhere?

PMID- 29824329
TI  - A Rural Tuberculosis Dispensary: A Guide to Its Equipment and Cost.

PMID- 29824328
TI  - A War Emergency Committee for London.

PMID- 29824331
TI  - Mumps and Parotitis.

PMID- 29824330
TI  - The Gloucestershire Royal Infirmary and Eye Institution.

PMID- 29824332
TI  - The Enlistment of Insured Persons.

PMID- 29824333
TI  - Fires Due to Air Raids.

PMID- 29824334
TI  - Disease Germs and Evolution: Epidemics, War, and the Public Health.

PMID- 29824335
TI  - Hospital and Health Law in the Empire and U.S.A.

PMID- 29824336
TI  - How to Sign a Prescription: The Latest Insurance Act Problem.

PMID- 29824337
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824338
TI  - London and Counties Medical Protection Society: The Profession and Its
      Safeguards.

PMID- 29824339
TI  - The Provision for Cases of Senile Insanity.

PMID- 29824340
TI  - Hospital and Institutional News.

PMID- 29824341
TI  - St. Magnus the Martyr and Hospital Sunday.

PMID- 29824343
TI  - St. Thomas's Hospital as a Type.

PMID- 29824342
TI  - The Voluntary Hospitals' Budget.

PMID- 29824344
TI  - The Seamen's Hospital.

PMID- 29824345
TI  - The Gospel of Personal Service.

PMID- 29824346
TI  - The Merriment of Mr. Stephen Coleridge.

PMID- 29824348
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824347
TI  - Royal Devon and Exeter Hospital.

PMID- 29824350
TI  - Hospital and Institutional News.

PMID- 29824349
TI  - Manchester Hospital War Work.

PMID- 29824351
TI  - The New Huts at St. Thomas's Hospital: The Problem of Additional Accommodation.

PMID- 29824352
TI  - A Medical Causerie.

PMID- 29824353
TI  - Professional Procedure and Panel Patients.

PMID- 29824354
TI  - My Commando Experiences in the Rebellion.

PMID- 29824355
TI  - The Hospital Life of the Wounded: Comradeship, Cheerfulness, and Cigarette
      Smoking.

PMID- 29824356
TI  - A Medical Causerie.

PMID- 29824357
TI  - The Treatment of Wounds in War.

PMID- 29824358
TI  - The War and Dietaries in Poor-Law Institutions: The Proper Way to Economise.

PMID- 29824359
TI  - Sir William Osler, Bart., on Some Results of the War.

PMID- 29824360
TI  - Hospital and Institutional News.

PMID- 29824361
TI  - The Military Cross for Medical Heroism: Decorations for Colonial Doctors.

PMID- 29824362
TI  - The New Chelsea Hospital for Women.

PMID- 29824364
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824363
TI  - Scottish Medical Service Emergency Committee.

PMID- 29824366
TI  - Suicide Made Easy.

PMID- 29824365
TI  - A List of Medical Offers of Service.

PMID- 29824367
TI  - Hospitals and the Spirit Tax: Mr. F. A. Hocking's Proposals.

PMID- 29824368
TI  - Bravery in the Ranks: the Work of the Overseas Medical Corps.

PMID- 29824369
TI  - The Position of War Consultants: The Government's New Policy.

PMID- 29824370
TI  - The Medical Profession and the War Office.

PMID- 29824371
TI  - Zeppelin Raids: Fire Precautions at the London Hospital.

PMID- 29824372
TI  - National Insurance Committees: Injustice and Unreason.

PMID- 29824373
TI  - A Medical Causerie.

PMID- 29824374
TI  - An Appreciation of Mr. W. G. Carnt.

PMID- 29824375
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824377
TI  - The Western Infirmary, Glasgow.

PMID- 29824376
TI  - Hospital and Institutional News.

PMID- 29824379
TI  - Endowed Beds with a History: II. In the Provincial and Scotch Hospitals.

PMID- 29824378
TI  - Tincture of Opium and Laudanum.

PMID- 29824381
TI  - Disabled Warriors and Parliament: Their First Claim on the Nation's Resources.

PMID- 29824380
TI  - The Pneumococcus Carrier.

PMID- 29824382
TI  - Leicester Panel Doctor Sued.

PMID- 29824384
TI  - Legal Notes for Institutional Workers.

PMID- 29824383
TI  - The Organisation of Hospital Fire Brigades.

PMID- 29824386
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824385
TI  - Tuberculin in Ophthalmic Practice: The Method Adopted and Results.

PMID- 29824387
TI  - The Evolution of the Modern Hospital: V. Medical Education, Administration, and
      Finance.

PMID- 29824388
TI  - A Territorial's "Internment" in an Isolation Hospital.

PMID- 29824389
TI  - The Easter Holiday.

PMID- 29824390
TI  - A Medical Causerie.

PMID- 29824392
TI  - The "Notes" in the Annual Returns: King Edward's Hospital Fund for London
      Statistics.

PMID- 29824391
TI  - The Colony for Cripples, Chailey.

PMID- 29824393
TI  - Hospital and Institutional News.

PMID- 29824394
TI  - The Medical Needs of the Army.

PMID- 29824395
TI  - The Department of Modern Nursing: XI. The Royal Infirmary of Edinburgh.

PMID- 29824397
TI  - Case Notes of an Obscure Disease.

PMID- 29824396
TI  - The Welsh Anti-Tuberculosis Campaign: The Measure of the Memorial Association's
      Activities.

PMID- 29824398
TI  - Some Points from Recent Circulars.

PMID- 29824399
TI  - Of Functional Nervous Disease.

PMID- 29824400
TI  - Possibly Abortive Cerebro-Spinal Fever.

PMID- 29824401
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824402
TI  - A Profitable Hospital Garden.

PMID- 29824403
TI  - The Metropolitan Asylums Board Report: 1914 a Strenuous Year.

PMID- 29824404
TI  - The Medical Needs of the Army and of the Hospitals.

PMID- 29824405
TI  - Hospital and Institutional News.

PMID- 29824406
TI  - The Need of More Facilities for Post-Graduate Study.

PMID- 29824407
TI  - A Doctor's Fear of Premature Cremation.

PMID- 29824408
TI  - From Pharmacy to Medicine.

PMID- 29824409
TI  - Some Public Health Reports.

PMID- 29824410
TI  - The Reserves of Beds in London Hospitals: King Edward's Hospital Fund for London
      Statistics.

PMID- 29824411
TI  - Dr. F. J. Waldo's Experiences in 1914.

PMID- 29824412
TI  - The Early Diagnosis of Pulmonary Tuberculosis from the View Point of General
      Practice.

PMID- 29824413
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824414
TI  - The Speech Clinic at St. Thomas's Hospital: The Case for General Adoption.

PMID- 29824416
TI  - A Medical Causerie.

PMID- 29824415
TI  - The Royal Hospital for Incurables.

PMID- 29824418
TI  - Military Methods in Medicine.

PMID- 29824417
TI  - Hospital and Institutional News.

PMID- 29824419
TI  - Birds in My Garden.

PMID- 29824420
TI  - Service and Silence.

PMID- 29824421
TI  - The Late Sir William Gowers, M.D., F.R.S.

PMID- 29824422
TI  - A Hospital for Belgian Soldiers.

PMID- 29824423
TI  - The London University Course.

PMID- 29824424
TI  - Graduate Study in London Special Hospitals.

PMID- 29824425
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29824426
TI  - The Royal Naval Medical Service In War and Peace.

PMID- 29824428
TI  - Cambridge University Course.

PMID- 29824427
TI  - Some Consequences of the War.

PMID- 29824430
TI  - Hospital and Institutional News.

PMID- 29824429
TI  - The Poor-Law Medical Service: Its Hospital Branch.

PMID- 29824431
TI  - The Medical Schools of the United Kingdom.

PMID- 29824432
TI  - Higher Diplomas.

PMID- 29824434
TI  - Manchester's Misfortune: The Retirement of Mr. Walter G. Carnt.

PMID- 29824433
TI  - Qualification and Registration.

PMID- 29824435
TI  - The Royal Army Medical Corps: How Matters Stand To-Day.

PMID- 29824436
TI  - London Post-Graduate Institutions.

PMID- 29824438
TI  - The Public Services.

PMID- 29824437
TI  - The Choice of Medicine as a Career.

PMID- 29824439
TI  - Oxford University Course.

PMID- 29824440
TI  - The English Conjoint Course.

PMID- 29824441
TI  - The Study of Tropical Medicine: Some Colonial Office Requirements.

PMID- 29824442
TI  - The Market Value of Hospital Service.

PMID- 29824444
TI  - Women's Future in Medicine: Achievements and Opportunities.

PMID- 29824443
TI  - Women in Pharmacy.

PMID- 29824445
TI  - The Educative Work of the School Doctor: Nasal Troubles in School Children.

PMID- 29824447
TI  - The Laundry Expenses of Hospitals: King Edward's Hospital Fund Statistics.

PMID- 29824446
TI  - Two Curious Bullet Wounds of the Neck.

PMID- 29824448
TI  - War Service at Home.

PMID- 29824449
TI  - How the Hospital Is Helping in the War.

PMID- 29824451
TI  - Open-Air Wards in Peace and War: The Lessons of the Cambridge Experiment.

PMID- 29824450
TI  - A Reduction in a Drug Account.

PMID- 29824452
TI  - The Hospital Egg: An Egg-Farmer's View.

PMID- 29824453
TI  - Hospitals and the Spirit Tax.

PMID- 29824455
TI  - Hospital and Institutional News.

PMID- 29824454
TI  - Research and Remedies.

PMID- 29824457
TI  - Legal Notes for Institutional Workers.

PMID- 29824456
TI  - Disablement Pensions and Reduced Sickness Benefit.

PMID- 29824458
TI  - Oldham's Work for the Wounded.

PMID- 29824459
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824460
TI  - The Responsibility for the Medical Care of Hospital Patients.

PMID- 29824461
TI  - The Education of the Defective in Canada: The Benefits of Auxiliary Classes.

PMID- 29824463
TI  - Hospitals and the Holiday Season.

PMID- 29824462
TI  - The Annual Dinner and the War.

PMID- 29824464
TI  - The New Sanatorium at Leicester.

PMID- 29824465
TI  - Nurse Training in Three Cottage Hospitals: Teignmouth, Dawlish, Newton Abbot.

PMID- 29824466
TI  - City Sanatorium, Birmingham.

PMID- 29824467
TI  - Discipline in the New Military Hospitals: Problems Arising from an Initial
      Mistake.

PMID- 29824468
TI  - Traumatism and Disease: Difficulties under the Workmen's Compensation Act.

PMID- 29824469
TI  - Hospital and Institutional News.

PMID- 29824470
TI  - The Pharmaceutical Society and the War.

PMID- 29824471
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824472
TI  - Queen Mary's Convalescent Auxiliary Hospitals.

PMID- 29824473
TI  - A Medical Causerie.

PMID- 29824474
TI  - The Hospital Needs of Our British Forces.

PMID- 29824476
TI  - The Teutonic Health Resorts: British Substitutes That Need Awakening.

PMID- 29824475
TI  - The Military Hospital, Sierra Leone.

PMID- 29824478
TI  - Institutions and the Drug Supply.

PMID- 29824477
TI  - Medical Baths for Invalid Soldiers.

PMID- 29824479
TI  - The Military Cross for an Army Doctor.

PMID- 29824480
TI  - Surgical Experiences: The Septic Infection of Wounds.

PMID- 29824481
TI  - Practical Points in Diagnosis and Treatment.

PMID- 29824482
TI  - Four Remarkable Cases: Genito-Urinary Sporotrichosis in New Zealand.

PMID- 29824483
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824484
TI  - Institutional Needs.

PMID- 29824486
TI  - Public Pharmacists' "Open Evening".

PMID- 29824485
TI  - The John Coupland Hospital, Gainsborough.

PMID- 29824488
TI  - Hypnosis Produced in Battle.

PMID- 29824487
TI  - The Performance of Operations.

PMID- 29824490
TI  - Condensed and Dried Milk and Tuberculosis: The Infectivity of Preserved
      Specimens.

PMID- 29824489
TI  - Hospital and Institutional News.

PMID- 29824491
TI  - The Handicap of the First-Born: The Small Family and Racial Progress.

PMID- 29824492
TI  - Legal Notes for Institutional Workers.

PMID- 29824494
TI  - Medical Service in the Highlands and Islands: Life and Needs of the Remote
      Doctors.

PMID- 29824493
TI  - Notes by a Surgeon on Active Service.

PMID- 29824495
TI  - The Cause of Poor-Law Reform: Two Typical Needs and the Remedy.

PMID- 29824497
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824496
TI  - The Hanbury Medallist.

PMID- 29824498
TI  - Voyages and Equipment of the Hospital Ship Madras.

PMID- 29824499
TI  - The Organisation of Military Medical Services.

PMID- 29824500
TI  - Women Students at Charing Cross Hospital.

PMID- 29824501
TI  - The Hospital Egg: Merchants' Views.

PMID- 29824503
TI  - The Parliamentary Debate on the Cost of National Insurance.

PMID- 29824502
TI  - Hospital and Institutional News.

PMID- 29824504
TI  - A Red Cross Memorial.

PMID- 29824505
TI  - Hospitals and the Spirit Tax.

PMID- 29824506
TI  - Pickled Eggs-And Preserving Jam.

PMID- 29824507
TI  - A Medical Causerie.

PMID- 29824508
TI  - Institutional Needs.

PMID- 29824509
TI  - Hospitals and the Spirit Duties.

PMID- 29824510
TI  - Hospital Sunday Special Number.

PMID- 29824511
TI  - Derbyshire Royal Infirmary.

PMID- 29824512
TI  - Professional Secrecy and Public Justice.

PMID- 29824513
TI  - Dispensary Attendances.

PMID- 29824515
TI  - Research and Remedies.

PMID- 29824514
TI  - Economy and Hospital Gardens.

PMID- 29824516
TI  - The Editor's Letter-Box.

PMID- 29824517
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824518
TI  - Economy and Hospital Gardens.

PMID- 29824519
TI  - Hospitals and the Spirit Tax: Where the British Medical Association's Case Fails.

PMID- 29824520
TI  - Hospital and Institutional News.

PMID- 29824521
TI  - Mental Hospitals and Recruiting: Replacing Attendants by Women Nurses.

PMID- 29824522
TI  - The Hospital Egg.

PMID- 29824524
TI  - Memorials to Medical Men: Westminster Abbey.

PMID- 29824523
TI  - Dispensary Attendances.

PMID- 29824525
TI  - The School Doctor's Outfit: I. The Lesson of Experience.

PMID- 29824526
TI  - Leicester Infirmary: Heating by Steam below Atmospheric Pressure.

PMID- 29824527
TI  - Mental Hospitals and Recruiting.

PMID- 29824528
TI  - The West London Hospital and the Three Examining Boards in London.

PMID- 29824529
TI  - The Hospital Egg.

PMID- 29824530
TI  - The Co-Operative Holiday System.

PMID- 29824531
TI  - The Responsibility of Names.

PMID- 29824532
TI  - Hospital Investments and Trustees: A Practical View of Depreciation.

PMID- 29824533
TI  - Voluntary Field Hospitals and Military Hygiene.

PMID- 29824534
TI  - Observation Wards in Isolation Hospitals: The Cruciform Plan.

PMID- 29824535
TI  - Hospitals and the Spirit Tax: The Government Amendment to the Finance Bill.

PMID- 29824536
TI  - Anti-Tuberculosis Organisation in London: Comprehensive Scheme for Adults and
      Children.

PMID- 29824537
TI  - Mentioned in Dispatches.

PMID- 29824538
TI  - Medical Organisation in German S.W. Africa: The Transport Problem.

PMID- 29824540
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824539
TI  - Hospital and Institutional News.

PMID- 29824542
TI  - A Medical Causerie.

PMID- 29824541
TI  - H.R.H. the Prince of Wales.

PMID- 29824543
TI  - The London Panel Committee.

PMID- 29824544
TI  - National Insurance Act Developments.

PMID- 29824545
TI  - A Testator's Intention.

PMID- 29824546
TI  - What Is a Clinical Lecture?

PMID- 29824548
TI  - War Work at the London Hospital: Staff, Salaries, and Air-Raid Decisions.

PMID- 29824547
TI  - Water-Cures in Peace and War: The Medical Bath in History.

PMID- 29824549
TI  - The Professional Classes Relief Fund: Dr. Scharlieb on Its Maternity Work.

PMID- 29824550
TI  - Hospital and Institutional News.

PMID- 29824551
TI  - Medical Schools and Medical Protection: "The Hospital"'s Criticism Endorsed.

PMID- 29824552
TI  - The Nature and Claims of Its Work.

PMID- 29824553
TI  - The Shortage in Hospital Medical Staffs: The Facts and the Remedies.

PMID- 29824554
TI  - The Sphygmometer and Aortic Regurgitation: An Opportunity for Valuable Work.

PMID- 29824555
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824556
TI  - National Service and the Hospitals.

PMID- 29824557
TI  - Anomalies and Curiosities of Medical Literature.

PMID- 29824558
TI  - Chapel of Great Barr Hall Institution, near Birmingham.

PMID- 29824559
TI  - The War Work of the Voluntary Hospitals.

PMID- 29824560
TI  - More Doctors Wanted-A Suggestion.

PMID- 29824561
TI  - The Standard of Mental Administration: Sir Thomas Clouston's Theories and
      Practice.

PMID- 29824563
TI  - Hospital and Institutional News.

PMID- 29824562
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824564
TI  - Legal Notes for Institutional Workers.

PMID- 29824565
TI  - A Plea for Co-Operation between the War Office and the National Insurance
      Commissioners.

PMID- 29824566
TI  - Treatment by Organic Extracts: A Fatal Case.

PMID- 29824567
TI  - A Medical Causerie.

PMID- 29824568
TI  - Eye Injuries in Warfare: The Reports at the Ophthalmological Congress.

PMID- 29824569
TI  - The After-Care of the Wounded.

PMID- 29824571
TI  - Military Medical Rank and Civil Practice.

PMID- 29824570
TI  - The Welfare of Blinded Soldiers.

PMID- 29824573
TI  - Derbyshire Children's Hospital.

PMID- 29824572
TI  - Public Pharmacists' Session Ends.

PMID- 29824574
TI  - Hospital and Institutional News.

PMID- 29824575
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824576
TI  - Radiology and Electro-Therapeutics in War-Time: Lessons from the Military
      Hospitals.

PMID- 29824577
TI  - Some Criticisms of Medical Fees.

PMID- 29824579
TI  - The Hospitals and Dispensaries of Bengal.

PMID- 29824578
TI  - Painless Childbirth in Twilight Sleep.

PMID- 29824580
TI  - Lateral Spinal Curvature-Urethroplasty.

PMID- 29824581
TI  - The Administration of the Lunacy Acts: Are Further Safeguards Needed?

PMID- 29824582
TI  - Enterprise in American Hospital Management: The Hutchinson Museum and Its
      Lessons.

PMID- 29824584
TI  - Albert Thomas, Our First Hospital Warrior: His Memorial, His Work and His
      Friends.

PMID- 29824583
TI  - Research and Remedies.

PMID- 29824585
TI  - The Royal Devon and Exeter Hospital.

PMID- 29824586
TI  - The Chancellor's Difficulties and a Way out.

PMID- 29824587
TI  - The Army, Hospital Governors and Resident Staffs.

PMID- 29824588
TI  - Cerebro-Spinal Meningitis: Its Infectivity and the Serum Treatment.

PMID- 29824589
TI  - The Call to the Medical Profession.

PMID- 29824590
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824591
TI  - Institutional Needs.

PMID- 29824592
TI  - Hospital and Institutional News.

PMID- 29824593
TI  - The Army Pharmaceutical Service.

PMID- 29824594
TI  - A Review of Its Poor-Law Medical Work.

PMID- 29824596
TI  - The Standard Opaque Meal for X-Ray Examination: The Cheapness of Barium Sulphate.

PMID- 29824595
TI  - Medical Reports on Hospital Patients.

PMID- 29824598
TI  - London Panel Committee.

PMID- 29824597
TI  - Building a Hospital in India: II. The Story of the Karnal District Hospital.

PMID- 29824599
TI  - St. Bartholomew's Hospital: Reports on Patients: Text of the Rules for the
      Medical Staff.

PMID- 29824600
TI  - Annual Meeting of Governors and General Council.

PMID- 29824602
TI  - Antiseptics and the War.

PMID- 29824601
TI  - Khaki, Rank, and Recognition for Dispensers in Military Hospitals.

PMID- 29824603
TI  - New Work and Its Problems at Ipswich.

PMID- 29824604
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824606
TI  - The Local Government Board and Guardians' Contracts.

PMID- 29824605
TI  - The Change of System on Its Trial.

PMID- 29824607
TI  - Hospital and Institutional News.

PMID- 29824608
TI  - Legal Notes for Institutional Workers.

PMID- 29824609
TI  - The New Physiological Buildings at Cardiff: The Question of a Treasury Grant.

PMID- 29824610
TI  - Hindrances to Medical Recruiting.

PMID- 29824611
TI  - Religio Medici Modereni.

PMID- 29824612
TI  - Heating of Leicester Infirmary.

PMID- 29824613
TI  - Female Nurses in Asylum Male Wards.

PMID- 29824615
TI  - A Medical Causerie.

PMID- 29824614
TI  - Endowed Beds with a History: I. In the London Hospitals.

PMID- 29824617
TI  - The Discharge of Tuberculous Soldiers from the French Army.

PMID- 29824616
TI  - Air-Raids and Bombardment of Institutions: The Government Insurance Scheme.

PMID- 29824618
TI  - The Educative Work of the School Doctor: II. Lantern Slides for Parents'
      Lectures.

PMID- 29824619
TI  - Hospitals and Spirit Tax.

PMID- 29824621
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824620
TI  - Hospitals and General Practitioners.

PMID- 29824622
TI  - Notes by a Surgeon on Active Service.

PMID- 29824623
TI  - Voluntary Hospitals and Military Hygiene.

PMID- 29824624
TI  - The Causes of Success and Failure.

PMID- 29824625
TI  - The Test of Conduct and Difficulty of Definition.

PMID- 29824626
TI  - Hospital and Institutional News.

PMID- 29824627
TI  - A Reduction in a Drug Account.

PMID- 29824628
TI  - Hospital Ships and the Right of Search: The Practical Lesson of the Ophelia Case.

PMID- 29824629
TI  - The Annual Conference and Exhibition.

PMID- 29824630
TI  - Hospitals and the Spirit Tax.

PMID- 29824631
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824632
TI  - General Medical Council and the Supply of Doctors.

PMID- 29824633
TI  - Medical Administration in the Trenches.

PMID- 29824634
TI  - Fires Due to Air Raids.

PMID- 29824636
TI  - The Cost to the State of National Health Insurance.

PMID- 29824635
TI  - The Editor's Letter-Box.

PMID- 29824637
TI  - The Medical Profession and the Notification of Births Act.

PMID- 29824638
TI  - The Educative Work of the School Doctor: Practical Points on Lectures to Parents.

PMID- 29824639
TI  - Hospital Unification in Cape Town: The Method of Control.

PMID- 29824641
TI  - The Rule in Bathing.

PMID- 29824640
TI  - War Service Badges for Hospital Staffs.

PMID- 29824642
TI  - Hospital and Institutional News.

PMID- 29824643
TI  - War Service Badges for Hospital Staffs: What to Avoid and What to Do.

PMID- 29824645
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824644
TI  - The Evolution of the Modern Hospital: VIII. The Problem of the Unpaid Staff.

PMID- 29824646
TI  - Arrears of Contributions and the Compulsory System.

PMID- 29824647
TI  - County Asylums as War Hospitals.

PMID- 29824648
TI  - Death Certificates and Insurance Companies: The Companies' Attitude and the
      Doctor's Rights.

PMID- 29824649
TI  - The Official Conditions for Obtaining Grants.

PMID- 29824650
TI  - The Valuation of Gifts in Kind.

PMID- 29824651
TI  - Hospital and Institutional News.

PMID- 29824652
TI  - The Training of the Health Visitor.

PMID- 29824653
TI  - Note by a Surgeon on Active Service.

PMID- 29824654
TI  - The Price of Coal (Limitation) Act, 1915: A Hospital Superintendent's Plea for
      Action.

PMID- 29824655
TI  - Female Nurses in Male Asylum Wards.

PMID- 29824656
TI  - Frauds on German Soldiers.

PMID- 29824657
TI  - Food Faddists and Something Worse.

PMID- 29824658
TI  - Bravery in the Ranks.

PMID- 29824659
TI  - Combined Coal and Gas Kitchener.

PMID- 29824661
TI  - The War Pinch on the Huns.

PMID- 29824660
TI  - Drug Values in the Treatment of Disease.

PMID- 29824662
TI  - War Service for Resident Medical Officers.

PMID- 29824664
TI  - Hospital and Institutional News.

PMID- 29824663
TI  - "The Uric Acid Fetish": The Decline of Its Flesh-Creeping Power.

PMID- 29824665
TI  - Shortage in X-Ray Operators.

PMID- 29824666
TI  - Miss Lena Ashwell's Concert Parties.

PMID- 29824667
TI  - The Public and Doctors for the Army.

PMID- 29824668
TI  - The Revised Uniform System of Accounts: The Three Funds Satisfied.

PMID- 29824669
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824670
TI  - War Effects on Sickness.

PMID- 29824671
TI  - The Finances of the Voluntary War Funds.

PMID- 29824672
TI  - Research and Remedies.

PMID- 29824673
TI  - On Hemiplegia in Childhood.

PMID- 29824674
TI  - Treatment of Tuberculous Bone Disease.

PMID- 29824675
TI  - The New Physiological Buildings at Cardiff: Sir William Osler's Wise Counsel.

PMID- 29824676
TI  - Organisation of a Red Cross Train: The Transit by Rail.

PMID- 29824677
TI  - How to Utilise Fat and Fish-Bones?

PMID- 29824678
TI  - The Comforts and Feeding of the Wounded during Transit: A Review of the Supply
      Organisation.

PMID- 29824680
TI  - Food in War-Time.

PMID- 29824679
TI  - A Medical Causerie.

PMID- 29824681
TI  - The Legal Status of the Hospital Ship in War-Time.

PMID- 29824682
TI  - Institutional Needs.

PMID- 29824683
TI  - Hospital and Institutional News.

PMID- 29824684
TI  - The Overseas Transport of Wounded: Life and Procedure on a Hospital Ship.

PMID- 29824685
TI  - Organising a Voluntary Aid Detachment: The Last Link in the Transport Service.

PMID- 29824686
TI  - The War Office and Its Temporary Hospitals.

PMID- 29824687
TI  - The After-Care of the Wounded.

PMID- 29824688
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824690
TI  - The Evolution of the Modern Hospital: VII. The Problem of the Unpaid Staff.

PMID- 29824689
TI  - Building a Hospital in India: I. The Story of the Karnal District Hospital.

PMID- 29824691
TI  - The National Care of the Sick and Wounded.

PMID- 29824692
TI  - A Red Cross Field Soup Kitchen: The Design and Equipment in Detail.

PMID- 29824694
TI  - Awards Recommended by the Committee for the Year 1915.

PMID- 29824693
TI  - Economy and the Food Question.

PMID- 29824695
TI  - British Hospitals Association: The Discussion on Mr. Buchanan's Paper.

PMID- 29824696
TI  - A Conversation at Charing Cross Hospital?

PMID- 29824698
TI  - The Shortage of Resident Medical Officers.

PMID- 29824697
TI  - The Hospital Egg: Imports and the Contract System.

PMID- 29824699
TI  - Report of the Committee of Distribution to the Council.

PMID- 29824700
TI  - A Medical Causerie.

PMID- 29824701
TI  - The Medical Corporations and the West London Hospital.

PMID- 29824702
TI  - A Year of War and Drug Prices.

PMID- 29824703
TI  - Larger Collections and Increased Grants: The Total of L70,600.

PMID- 29824704
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29824705
TI  - Hospital and Institutional News.

PMID- 29824706
TI  - The School Doctor's Outfit: II. The Contents of the Doctor's Bag.

PMID- 29824707
TI  - Nurses' and Probationers' Food.

PMID- 29824709
TI  - The Discipline of Suffering.

PMID- 29824708
TI  - Alcohol at Certain General and Special Metropolitan Hospitals, 1875-6 to 1885.

PMID- 29824710
TI  - Invalid Passengers on Board Ship.

PMID- 29824711
TI  - From a Hospital for the Insane: The Few November Flowers.

PMID- 29824712
TI  - Difficult Cases.

PMID- 29824713
TI  - Annotations: The Out-Patient Question.-The Exhibition of Competition Plans.
      Incurable and Chronic v. Acute Diseases.

PMID- 29824715
TI  - The Hospitals of Our Grandfathers.

PMID- 29824714
TI  - Infectious Fevers and Diseases in London.

PMID- 29824716
TI  - Notes and News: The Registration Fee System.-Cottage Hospitals.-New Children's
      Hospital.-Statue of Sister Dora.-Out-Patients' Subscription Boxes.-Miller
      Hospital at Greenwich.-Vacancies.-Sheffield School of Medicine.-Cremation Society
      of England.-Church Parades.-New Chapel for Dublin.-The Bishop of Durham and the
      Newcastle Infirmary.-The Highgate Infirmary.-Professor Dyce-Davidson.-Mr. Emil
      Behnke.-Doctor Collie on Enteric Fever.-Temporary Hospitals in Liverpool, etc.,
      etc.

PMID- 29824717
TI  - Discharged. Not Where to Lay His Head: Chapter VI.

PMID- 29824718
TI  - Fruit for Hospitals.

PMID- 29824719
TI  - The Registration Fee System.

PMID- 29824720
TI  - Good Work Done, and to Be Done.

PMID- 29824722
TI  - Disorders of Digestion: First Notice.-Introductory.

PMID- 29824721
TI  - The Classes and the Masses: A Word to the Wise: II. A Christmas Appeal: Help the
      Hospitals.

PMID- 29824724
TI  - Sympathy.

PMID- 29824723
TI  - National Hospital for Paralysed and Epileptic.

PMID- 29824725
TI  - Isolation Huts: An Inquiry from America.

PMID- 29824726
TI  - A Hospital Matron on Hospital Morals.

PMID- 29824727
TI  - Notes and News: Miscellaneous-Medicine Bottles for Hospitals.-The Fleming
      Memorial Hospital.-The Workington Infirmary.-Dictionaries for Hospitals.-The
      Surgical Aid Society.-The Burnley Mills and Workshops.-New Hospital for Dublin.
      Bazaars.-Hospital Imposture.-Bequests.-Tradesmen's Presents.-Vacancies.-Mercer's
      Hospital, Dublin.-Penzance Convalescents' 'Home.-Hospital Collections.-New
      Cottage Hospital for Ripon.-The Royal Albert Hospital, Devonport.-Bazaar and
      Fancy Fair at the Rink, Dublin.-Presentation to Mrs. Mercier, etc. etc.

PMID- 29824729
TI  - Sister Olive: A Hospital Romance: Chapter V.

PMID- 29824728
TI  - The Story of the Hospitals.

PMID- 29824730
TI  - Santa Claus' Garner.

PMID- 29824731
TI  - Our First Christmas Day.

PMID- 29824732
TI  - Incidents of Animal Life: Stories about Rats.

PMID- 29824733
TI  - Notes and News: Miscellaneous.-London School of Medicine for Women.-Large
      Legacies.-Durham County Hospital.-West Bromwich District Hospital.-The Proposed
      Hospital for West Ham.-New Cottage Hospital at Abingdon.-"Sister Dora."-Wanted:
      Fruit and Linen for Hospitals.-Pictures in the Wards.-Mental Excitement: A
      Competition Item, etc., etc.

PMID- 29824734
TI  - Flowers, Ferns, and Ward Decorations.

PMID- 29824736
TI  - Good Asylum Attendants for the Insane: Of Interest to All.-Published Facts.-Fifty
      Years Ago, and Since. The Ideal Attendant.-The Present Want.

PMID- 29824735
TI  - The Story of the Hospitals.

PMID- 29824738
TI  - Diseases of Children: Feverishness.-Teething.-The First Teeth.-Thrush.-Discharge
      from the Eyes.-Eczema of Head.

PMID- 29824737
TI  - A Noble Profession: Nursing the Sick: Half a Century Ago.-Later Developments.
      Training of Nurses.

PMID- 29824739
TI  - Discharged. Not Where to Lay His Head: Chapter V.

PMID- 29824740
TI  - Annotations: The Metropolitan Local Press.-Advertising Doctors and Secret
      Remedies.-A Just Complaint.-Hospitals and Dispensers.

PMID- 29824741
TI  - The Divine Purpose.

PMID- 29824742
TI  - Poor-Law Infirmaries, Medical Education, and the People.

PMID- 29824743
TI  - In a Hospital Ward.

PMID- 29824744
TI  - What Should Be the Training for Cottage Hospital Matrons?

PMID- 29824745
TI  - Hospital Worthies.

PMID- 29824746
TI  - Flowers, Ferns, and Ward Decorations.

PMID- 29824747
TI  - Annotations.

PMID- 29824749
TI  - Wanted a Home for a Lady with Creeping Paralysis.

PMID- 29824748
TI  - Words of Consolation.

PMID- 29824751
TI  - Difficult Cases.

PMID- 29824750
TI  - Discharged. Not Where to Lay His Head: Chapters II, III.

PMID- 29824752
TI  - Well Done!

PMID- 29824753
TI  - Notes and News.

PMID- 29824754
TI  - Till the Doctor Comes.

PMID- 29824755
TI  - Medical Books and General Readers.

PMID- 29824757
TI  - The Case of Spinal Curvature.

PMID- 29824756
TI  - Incidents of Animal Life.

PMID- 29824758
TI  - The Privilege of Suffering.

PMID- 29824759
TI  - The Story of the Hospitals.

PMID- 29824760
TI  - Hospital Worthies.

PMID- 29824761
TI  - Flowers, Ferns, and Ward Decorations.

PMID- 29824762
TI  - Notes and News: The Queen at Longmore Hospital.-Miscellaneous.-The Late W. H.
      Vanderbilt.-New Clinical Hospital.-The Hospital Sunday Movement in Birmingham.
      Munificent Bequests.-The Nottingham General Hospital.-Upton Lunatic Asylum.
      Trained Nurses' Club.-West Ham Hospital Sustentation Fund.-Proposed Hospital for
      Bournemouth.-John Howard on Registration-Fee Payments.-New Hospital at Hastings.
      The Working Classes and the Hospitals, etc., etc.

PMID- 29824763
TI  - Annotations: Hospitals, Provident Dispensaries, and the Pay System.-Hospital
      Sunday and Individual Contributions.-Hospital Sunday Practices to Be Avoided.-The
      Asylums Board and Clinical Teaching.

PMID- 29824764
TI  - The Importance of Maintaining Medical Charities.

PMID- 29824765
TI  - Dolly in the Hospital.

PMID- 29824766
TI  - The Hospitals of Our Grandfathers, at Home and Abroad.

PMID- 29824767
TI  - Ought Asylums to Rank as Hospitals?

PMID- 29824768
TI  - Alcohol at the London Hospital.

PMID- 29824769
TI  - Officers' Food and the Regulation of Meals.

PMID- 29824770
TI  - Difficult Cases.

PMID- 29824771
TI  - Discharged. Not Where to Lay His Head: Chapter IV.

PMID- 29824772
TI  - Notes and News: H.R.H. the Prince of Wales and the Exhibition Boxes.-Prince
      Albert Victor at Burnley.-Successful Architects.-Dr. Hazlerigg and Devonshire
      Hospital, Buxton.-The Earl of Derby at Manchester.-Staff-Nurses Promoted.-Bath
      Hospital, Harrogate.-Resignation of Mr. Worthington.-Devonshire Hospital, Buxton.
      An Accident.-Amalgamation in Sunderland.-Improvements at Westminster Hospital,
      etc.

PMID- 29824773
TI  - Flowers, Ferns, and Ward Decorations: The Charm and Beauty of Flowers.-Christ and
      the Flowers.

PMID- 29824774
TI  - Annotations: Dangerous Reticence.-Hospitals and Rates.-Hope for the Hopeless.

PMID- 29824775
TI  - "The Hospital," Elementary Schools and the Public.

PMID- 29824776
TI  - Words of Consolation.

PMID- 29824778
TI  - The Groan of the Willing Horse.

PMID- 29824777
TI  - The Hospital Problem: The Utility and Necessity of Hospitals.-The Facts Stated.
      Few Voluntary Supporters.

PMID- 29824779
TI  - Nurses' Food.

PMID- 29824780
TI  - The Out-Patient Registration Fee System.

PMID- 29824782
TI  - Old-Fashioned Pauper Infirmaries.

PMID- 29824781
TI  - A Plea for the Dumb Animals.

PMID- 29824783
TI  - Annotations: Residential Accommodation for Medical Students.-Infected Cabs.
      Lodging-House Keepers and Their Consciences.

PMID- 29824785
TI  - Nurses' Food and Feeding.

PMID- 29824784
TI  - Nursing at St. Mary's Hospital.

PMID- 29824787
TI  - The Privilege of Suffering.

PMID- 29824786
TI  - Milk and Alcohol in Children's Hospitals, etc.

PMID- 29824788
TI  - Hospital Saturday Fund.

PMID- 29824789
TI  - Diseases of Children.

PMID- 29824790
TI  - Homes on the Riviera.

PMID- 29824791
TI  - Subscription-Boxes in Out-Patient Departments.

PMID- 29824792
TI  - Notes and News: H.R.H. the Duke of Cambridge.-Miscellaneous.-Fever Cases in the
      Metropolis.-Affairs at the Western Asylum.-Trade Societies' Demonstrations.
      Friendly Societies and the Hospitals.-The Dudley Dispensary.-Toys for Poor
      Children.-Vacancies.-The Prince's Cinderellas.-Royal Aberdeen Infirmary.-Taunton
      and Somerset Hospital.-"The Darlington Hospital Scandal," etc.

PMID- 29824794
TI  - Medical Students, Their Schools and Schoolmasters.

PMID- 29824793
TI  - Discharged. Not Where to Lay His Head: Chapters VII, VIII, IX.

PMID- 29824795
TI  - Flowers, Ferns, and Ward Decorations.

PMID- 29824796
TI  - Nurses' Trials-Weariness.

PMID- 29824797
TI  - Annotations: A Libel on Hospital Sunday.-The Home and the Hospital at Bristol.

PMID- 29824799
TI  - The Hospital.

PMID- 29824798
TI  - The Wesleyans and Hospital Sunday.

PMID- 29824800
TI  - He Laid down His Life: An Infirmary Story.

PMID- 29824801
TI  - Nursing at Queen Charlotte's Lying-In Hospital.

PMID- 29824802
TI  - Notes and News: Items.-The Duke of Cambridge and the German Hospital.-The
      Metropolitan Convalescent Institution.-Hospital Saturday at New York.-Vacancies.
      Hospital Sunday in the Metropolis.-Lord Chelmsford and the Covalescent Dinner
      Society.-The Royal Maternity Charity.-Medical Charities.-The Bristol Dispensary.
      Overcrowding at Hospitals.-Fancy Bazaars in Aid of the Hospitals.-Memorial at
      Leicester Infirmary, etc., etc.

PMID- 29824803
TI  - Workers v., Beggars.

PMID- 29824804
TI  - The Latest of the Water Cures.

PMID- 29824806
TI  - Workhouse Visiting and Management.

PMID- 29824805
TI  - Incidents of Animal Life.

PMID- 29824808
TI  - Ulcerated Legs : Their Care and Cure.

PMID- 29824807
TI  - The Common Accidents of Every-Day Life: Early Misadventures.

PMID- 29824809
TI  - General Inquiries.

PMID- 29824810
TI  - To Our Readers.

PMID- 29824811
TI  - Officers' Food, and the Regulation of Meals.

PMID- 29824812
TI  - Notes and News.

PMID- 29824813
TI  - Flowers, Ferns, and Ward Decorations.

PMID- 29824814
TI  - The Story of the Hospitals.

PMID- 29824816
TI  - Words of Consolation.

PMID- 29824815
TI  - Difficult Cases.

PMID- 29824817
TI  - Hospital Administration: Mr. Sturge and the Alcohol Question.

PMID- 29824818
TI  - Hospital Worthies.

PMID- 29824819
TI  - Help at Hand, Brother.

PMID- 29824820
TI  - Discharged. Not Where to Lay His Head: Chapter I.

PMID- 29824821
TI  - The Blind.

PMID- 29824822
TI  - Sympathy.

PMID- 29824823
TI  - Flowers, Ferns, and Ward Decorations.

PMID- 29824824
TI  - Feeding: Preservation of Ice.

PMID- 29824825
TI  - The Gratitude of Hospital Patients.

PMID- 29824826
TI  - The System of Nursing at the London Hospital.

PMID- 29824827
TI  - Notes and News: Miscellaneous.-Donations.-Fancy Dress Ball in Aid of the Chelsea
      Hospital for Women.-The City Orthopaedic Hospital.-Guy's Hospital.-Entertainment
      in Aid of Charing Cross Hospital.-New Home for English and American Girls in
      Berlin.-Ancient Order of Foresters' Convalescent Home.-Queen Victoria Maternity
      Hospital at Bristol.-Hospital Appeals.-The Great Northern Central Hospital.
      Competition among Doctors.-The Ancoats Hospital.-The Children's Ministering
      Angels League.-The Hull Children's Hospital.-Testimonial to Sir Andrew Clark.-The
      Thronemount Consumption Hospital, etc., etc.

PMID- 29824828
TI  - The New Year: The Association and "The Hospital".

PMID- 29824829
TI  - Should "Sisters" and "Nurses" Marry?: The Story of "Sister Olive".

PMID- 29824830
TI  - Remedies: New and Old.

PMID- 29824831
TI  - Sister Olive: A Hospital Romance: Chapter VI.

PMID- 29824832
TI  - Lancaster Town: Its Mayor and Its Hospital.

PMID- 29824833
TI  - Child Torture in Christian England.

PMID- 29824834
TI  - The Story of the Hospitals: The British Home for Incurables.

PMID- 29824835
TI  - More Christmas Festivities at the Hospitals.

PMID- 29824836
TI  - Sympathy.

PMID- 29824837
TI  - Notes and News: The Duke of Westminster and the Hospital for Women, Soho.
      Miscellaneous Items.-Presentation of Busts to the Manchester Royal Infirmary.
      Vacancies.-Hospital Enlargements.-Retirement of Mrs. Rahn.-The Norwich Hospital
      Sunday Fund Collection.-Chard and the Jubilee.-The "Elephant Man."-Edinburgh
      Royal Infirmary Report.-Income of London Hospitals.-Towns without Hospitals.
      Hospital Bazaar at Hastings.-The Edinburgh Provident Dispensary.-The Founder of
      Guy's Hospital.-Dramatic Entertainments in Aid of the Hospitals.-The Nursery
      Hospital at Nottingham.-Christmas Entertainments at the Hospitals.-The Newcastle
      Infirmary.-Improvements at the Suffolk General Hospital, etc.

PMID- 29824838
TI  - Practical Hints for the Sick-Room.

PMID- 29824839
TI  - A Good Work Well Finished: "Finis Coronat Opus".

PMID- 29824840
TI  - Hospital Support a Public Duty.

PMID- 29824841
TI  - The Past, the Present, and the Future of Hospitals.

PMID- 29824843
TI  - Flowers, Ferns, and Ward Decorations.

PMID- 29824842
TI  - Annotations: Books and Periodicals.-Who Is Responsible?-Eight Years an Out
      Patient.-Lunatics and Doctors.-Take Care of Your False Teeth.

PMID- 29824844
TI  - Hospital Co-Operation and Mutual Help.

PMID- 29824846
TI  - The Provision for Nursing Fevers in London.

PMID- 29824845
TI  - Notes and News: Miscellaneous.-Munificent Bequests.-"The Queen's Bed" at the
      North London Hospital.-The Children's Hospital at Paddington Green.-Lord Meath on
      the Maintenance of Hospitals.-The Netherfield Road Hospital.-Gifts to the
      Kilmarnock Infirmary.-Vacancies.-The St. John's Ambulance Association.-Increase
      of Pauper Lunatics.-The Stratford Dispensary.-The Great Northern Central
      Hospital.-Medical Classes at Aberdeen University-Hospital Architects.-The Kyrle
      Society, etc.

PMID- 29824847
TI  - Concerning Medical Students.

PMID- 29824848
TI  - Willie: A True Story.

PMID- 29824849
TI  - A Case of Paralysis.

PMID- 29824850
TI  - Recent Novelties in Sick-Room Appliances.

PMID- 29824851
TI  - Hope.

PMID- 29824852
TI  - Fomentations, Lotions, and Bed-Sores.

PMID- 29824853
TI  - Nurses' Trials-Martha and Mary.

PMID- 29824854
TI  - Growing Old.

PMID- 29824855
TI  - Nursing Institutions and Metropolitan Hospitals.

PMID- 29824857
TI  - Unite and Co-Operate.

PMID- 29824856
TI  - Annotations: Waking up at the Dorset County Hospital.-A Third Hospital for
      Glasgow.-Nurses at Play.

PMID- 29824858
TI  - A Great Opportunity for Good.

PMID- 29824859
TI  - Employment for Epileptics.

PMID- 29824861
TI  - Deaf-Mutes and Consanguineous Marriages.

PMID- 29824860
TI  - Notes and News: Miscellaneous Items.-The Payment of Nurses.-Lectures for Nurses.
      The Frome Cottage Hospital.-Derbyshire Hospital for Sick Children.-Vacancies.
      Queen's Hospital, Birmingham.-Cremation.-Pianos in Hospitals, etc., etc.

PMID- 29824862
TI  - Digestion and Dyspepsia.

PMID- 29824863
TI  - Infectious Fevers and Diseases in London.

PMID- 29824864
TI  - The Mildmay Mission Hospital.

PMID- 29824865
TI  - Sister Olive: A Hospital Romance: Chapters II, III.

PMID- 29824866
TI  - Creeping Paralysis in a Lady.

PMID- 29824868
TI  - Cheerfulness.

PMID- 29824867
TI  - Counsel's Opinion.

PMID- 29824869
TI  - How to Enter the Medical Profession.

PMID- 29824870
TI  - Among the Out-Patients.

PMID- 29824872
TI  - Lord Salisbury's Article.

PMID- 29824871
TI  - Hospital Revenues Today and Ten Years Ago.

PMID- 29824873
TI  - The Solicitor's Statement of Facts.

PMID- 29824874
TI  - Notes and News: The Late Mr. O. E. Coope.-Lord Salisbury's Appeal for the
      Hospitals.-The Queen's Jubilee Memorials.-Miscellaneous.-Enlargement of the
      Bristol Eye Hospital.-Vacancies.-Competition Prizes for Orphanage Designs.-The
      Globe Parcel Delivery Co.-Appeals.-Sherburn Hospital and the Charity
      Commissioners.-The Kyrle Society.-The New Infirmary at Workington.-Aberdeen Royal
      Infirmary, etc.

PMID- 29824875
TI  - Sermon by the Lord Bishop of London at St. Thomas's Hospital.

PMID- 29824876
TI  - A Hospital Impostor.

PMID- 29824877
TI  - Annotations: Coventry's Care for Its Sick Children.-The First Medical General
      Election.

PMID- 29824878
TI  - Flowers, Ferns, and Ward Decorations.

PMID- 29824879
TI  - The Queen's Jubilee: How Will the Hospitals Celebrate It?

PMID- 29824880
TI  - Employment for a Poor Half-Witted Girl.

PMID- 29824881
TI  - Homes for Incurables: Free Payments v. The Voting System.

PMID- 29824882
TI  - Sympathy.

PMID- 29824883
TI  - Incidents of Animal Life: Stories about Dogs.

PMID- 29824884
TI  - Hospitals, Schools, and Boys and Girls.

PMID- 29824885
TI  - From the Home to the Hospital.

PMID- 29824886
TI  - Annotations: Is Alcohol a Food?-Word Puzzles and Gambling.-A Royal Commission on
      Hospitals.

PMID- 29824887
TI  - The Common Accidents of Every-Day Life: Early Misadventures; the Infant; the
      Dangers Connected with Swallowing; Causes of Choking: Their Symptoms and
      Treatment.

PMID- 29824888
TI  - The Peoples' Want in North London.

PMID- 29824889
TI  - Metropolitan Poor-Law Infirmaries and Medical Teaching.

PMID- 29824891
TI  - Notes and News.

PMID- 29824890
TI  - Nursing in America.

PMID- 29824892
TI  - The Wesleyans and Hospital Sunday.

PMID- 29824893
TI  - Hospital Funds and the Working Classes.

PMID- 29824894
TI  - The After-Care of Asylum Convalescents: An Interview with Lord Brabazon.

PMID- 29824895
TI  - The Financial Depression at the Metropolitan Hospitals To-Day and Ten Years Ago.

PMID- 29824896
TI  - Seasonable Decorations.

PMID- 29824897
TI  - Bathing.

PMID- 29824898
TI  - Reminiscences of the Insane.

PMID- 29824900
TI  - Contentment.

PMID- 29824899
TI  - The Classes and the Masses: A Word to the Wise: I. The Lessons of the Times.

PMID- 29824902
TI  - Sister Olive: A Hospital Romance: Chapter IV.

PMID- 29824901
TI  - A District Nurse and Her Patients.

PMID- 29824903
TI  - Annotations: The Hospitals Week Movement-Temperance and Total Abstinence.-A
      Hospital for Oban.

PMID- 29824904
TI  - "The Hospital" and "The Globe": Lord Salisbury's Article.

PMID- 29824905
TI  - Doctors' Workshops: Poor-Law Infirmaries.

PMID- 29824906
TI  - Metropolitan Hospital Sunday Fund, 1886.

PMID- 29824907
TI  - Hospitals for Lady Probationers.

PMID- 29824908
TI  - Help the Hospitals.

PMID- 29824909
TI  - Notes and News: Miscellaneous-Legacies to the Manchester Hospitals.-Bazaars.
      Vacancies.-The West London Hospital.-The Truth Toy Fund.-Hospital Students and
      Their Patients.-Miss Wood on the Management of Infants and Children.-Nairn
      Hospital and the Sanitary Committee.-Wellington Dispensary and the Resignation of
      Dr. Rider.-New Cottage Hospital for Abingdon, etc.

PMID- 29824910
TI  - The Story of the Hospitals: The London Hospital.

PMID- 29824911
TI  - The General Hospital, Nottingham.

PMID- 29824913
TI  - Special Notices.

PMID- 29824912
TI  - The Golden Age of Pauperism.

PMID- 29824914
TI  - Total Abstinence and Common Sense.

PMID- 29824915
TI  - Harvey Interviewed.

PMID- 29824916
TI  - The "Truth" Toy Fund.

PMID- 29824917
TI  - Notes and News: H.R.H. Princess Christian and the after Care Association.
      Bequests.-Miscellaneous.-Brompton Hospital and Trained Nurses.-Vacancies.-The
      Guest Hospital at Dudley.-Jubilee Cottage Hospital for Melton.-The Driffield
      Cottage Hospital.-Concert at the Wrexham Infirmary.-Legacies to the Brompton
      Consumption Hospital.-Improvements at the Chichester Infirmary.-Hospital and
      Infirmary Reports, etc.

PMID- 29824919
TI  - Annotations: The Analysts on Their Defence.-Flogging in Board Schools.
      Hydrophobia: Society for Its Prevention.

PMID- 29824918
TI  - In the Night Time.

PMID- 29824920
TI  - Reminiscences of the Insane.

PMID- 29824922
TI  - General Hints on Nursing.

PMID- 29824921
TI  - Sister Olive: A Hospital Romance: Chapter I.

PMID- 29824923
TI  - The Training of Midwives.

PMID- 29824924
TI  - Cheerfulness.

PMID- 29824925
TI  - Flowers for Hospitals and Schools.

PMID- 29824926
TI  - Sympathy in the Physician.

PMID- 29824928
TI  - The Story of "Sister Olive".

PMID- 29824927
TI  - Who Did It?

PMID- 29824930
TI  - Christmas Day in a London Hospital.

PMID- 29824929
TI  - Christmas at "The Foundling".

PMID- 29824931
TI  - Hospital Centralisation at Aberdeen.

PMID- 29824932
TI  - The Hospitals' Celebration of the Queen's Jubilee.

PMID- 29824933
TI  - Glasgow University and Medical School.

PMID- 29824935
TI  - The Story of "Sister Olive".

PMID- 29824934
TI  - An Intractable Child.

PMID- 29824936
TI  - Management of the Eye, Ear, and Throat.

PMID- 29824937
TI  - Notes and News: Miscellaneous.-Donations.-Queen's Jubilee Proposals.-The
      Hospitals Association.-Marvellous Calculations.-Four Christmas Days in Hospital.
      Vacancies.-The Camberwell Infirmary.-New Hospital for St. Albans.-The Lord Mayor
      and the Marylebone Infirmary.-Proposed Hospital for Southend.-The "Sister Olive"
      Question.-Christmas Day at the Oldham Infirmary.-Westminster Hospital.-Hospital
      Smuggling, etc., etc.

PMID- 29824938
TI  - A Poor Half-Witted Girl.

PMID- 29824939
TI  - Hospital Funds and the Working Classes.

PMID- 29824940
TI  - Christmas Festival at the Hospitals.

PMID- 29824941
TI  - Reminiscences of the Insane.

PMID- 29824942
TI  - Reminiscences of the Insane.

PMID- 29824943
TI  - The Training of Midwives.

PMID- 29824944
TI  - Morphio-Mania.

PMID- 29824945
TI  - The Hull Infirmary.

PMID- 29824946
TI  - The Medicinal Properties of Woodall Spa Waters.

PMID- 29824947
TI  - A Hospital Appeal.

PMID- 29824948
TI  - Nurses' Wages Fixed by a Dutch Auction.

PMID- 29824949
TI  - A Relic of John Hunter.

PMID- 29824950
TI  - Annotations: Sir James Picton on Homoeopathy.-The Proposal to Change Hospital
      Sunday.-Is Medical Practice Humbug?

PMID- 29824951
TI  - Hopeless, Offensive, and Incurable.

PMID- 29824952
TI  - Among the Out-Patients.

PMID- 29824953
TI  - Erratum: The Richmond Hospital: A Correction.
AB  - [This corrects the article on p. 300 in vol. 1.].

PMID- 29824954
TI  - In the Children's Ward.

PMID- 29824955
TI  - Nurses' Trials.-Weariness and Prayer.

PMID- 29824956
TI  - Notes and News: Munificent Donation to Morley House.-Stock Exchange Collection.
      Vacancies, etc.

PMID- 29824957
TI  - The Best Tank for Disinfecting Linen.

PMID- 29824958
TI  - Poultices.

PMID- 29824959
TI  - Worthy of Sympathy and Support.

PMID- 29824960
TI  - The Story of the Hospitals: The Cancer Hospital, Brompton.

PMID- 29824961
TI  - Hospitals, the Sick Poor, and All England.

PMID- 29824962
TI  - The One Law of Life.

PMID- 29824963
TI  - The All Saints Sisters' Home for Trained Nurses.

PMID- 29824964
TI  - Hospital Housekeeping.

PMID- 29824965
TI  - Sympathy with Nurses.

PMID- 29824966
TI  - Annotations: The Battle of St. Albans.-Hospital Sunday in Birmingham.-The
      Spectator and Vivisection.

PMID- 29824968
TI  - Sick Appliances for the Household.

PMID- 29824967
TI  - Disorders of Digestion: The Mouth.

PMID- 29824969
TI  - The Story of the Hospitals: The British Home for Incurables.

PMID- 29824970
TI  - Reminiscences of the Insane.

PMID- 29824972
TI  - Flowers, Ferns, and Ward Decorations.

PMID- 29824971
TI  - Clothing and Health.

PMID- 29824973
TI  - America and Its Charities: A Suggestive Experience.

PMID- 29824975
TI  - Poor-Law Infirmaries and General Hospitals: Discussion on Colonel Montefiore's
      Paper.

PMID- 29824974
TI  - Notes and News: Miscellaneous Items.-Presentation to the Founders of the Stanley
      Hospital.-Hospital Reports.-Vacancies.-The Great Northern Central Hospital..
      Kensington District Nursing Association.-Proposed Hospital for Mine Women, etc.,
      etc.

PMID- 29824976
TI  - A Retrospect of Christmas.

PMID- 29824977
TI  - Reminiscences of the Insane.

PMID- 29824978
TI  - Uniformity in Hospital Accounts.

PMID- 29824979
TI  - Nurses' Pension Funds.

PMID- 29824980
TI  - Faith-Healing.

PMID- 29824981
TI  - Annotations: Provident Dispensaries.-Aurard's Incubator.-Town v. Country.

PMID- 29824982
TI  - Nurses' Pension Funds.

PMID- 29824984
TI  - Heart Disease: A Word of Comfort.

PMID- 29824983
TI  - Nursing Institutions and Hospitals.

PMID- 29824985
TI  - An Ambulance at Work.

PMID- 29824987
TI  - Notes and News: Royalty and the Hospitals.-Miscellaneous Items.-Hospital and
      Infirmary Balls.-The Charing Cross Hospital.-The Essex Convalescent Home.-Lord
      Halsbury and the National Hospital for Paralysed and Epileptic.-The Beau Site
      Convalescent Home.-Vacancies.-Hospitals in India.-An Unexpected Donation.-The
      Cancer Hospital.-Donations and Legacies to Medical Charities.-The Bethnal Green
      Working Men's Society.-Hospital Saturday Fund: Meeting of Delegates.-The
      Worcester Ophthalmic Hospital.-The Peterborough Infirmary.-Jubilee Hospital
      Proposals, etc.

PMID- 29824986
TI  - Nurses' Pension Funds.

PMID- 29824988
TI  - The Coster's Customer: Or, How I Earned Twenty Pounds.

PMID- 29824989
TI  - Nurses' Trials-No Drudgery.

PMID- 29824990
TI  - Nurses' Pension Funds.

PMID- 29824991
TI  - Incubators for Infants.

PMID- 29824992
TI  - Notes and News: Miscellaneous Items.-Madame Roze at the Jaffray Hospital.
      Entertainment at Lowther Lodge.-The Seamen's Hospital.-Vacancies.-The Stroud
      General Hospital.-The British Hospital at Port Said.-Donations and Legacies to
      Medical Charities.-The Macclesfield Infirmary.-The Lord Provost of Glasgow and
      the Hospitals, etc., etc.

PMID- 29824994
TI  - An Acrostic.

PMID- 29824993
TI  - Minor Injuries, etc.

PMID- 29824996
TI  - Nurses' Trials-Temper.

PMID- 29824995
TI  - Infectious v. Non-Infectious Convalescents.

PMID- 29824997
TI  - Hospital Huts.

PMID- 29824998
TI  - Nurses' Recreations.

PMID- 29824999
TI  - Nursing Institutions and Hospitals: The Case for the Private Institutions and
      Nurses.

PMID- 29825001
TI  - In the Children's Ward: Chap. I.

PMID- 29825000
TI  - Incidents of Animal Life.

PMID- 29825002
TI  - Farthing Dinners.

PMID- 29825003
TI  - Chats about Medical Museums.

PMID- 29825005
TI  - Our Skin, and How to Take Care of It.

PMID- 29825004
TI  - Doctors Described by Nurses and Patients.

PMID- 29825006
TI  - Annotations: Miss Manson and Trained Nurses.-Drinks Wanted.-Who Stands Sponsor
      for the Matrons?

PMID- 29825007
TI  - A Few November Flowers.

PMID- 29825008
TI  - The Hospitals Association: The Conversazione.

PMID- 29825009
TI  - Country Physicians: The Colchester Imbroglio.

PMID- 29825010
TI  - The Ethics of the Sewage Question.

PMID- 29825011
TI  - The Modern Workhouse Infirmary.

PMID- 29825012
TI  - Reminiscences of the Insane.

PMID- 29825013
TI  - Nurses' Remuneration and Pensions.

PMID- 29825014
TI  - Children's Food and Management.

PMID- 29825015
TI  - Patience.

PMID- 29825017
TI  - The Training of Midwives.

PMID- 29825016
TI  - The Editor's Letter-Box.

PMID- 29825018
TI  - Notes and News: Donation to the Longmore Hospital by the Queen.-Miscellaneous.
      Brackley Cottage Hospital.-New Eye Hospital for Cardiff.-Musical Entertainments
      at Brompton Hospital.-The Mogg Memorial Hospital.-Llanelly Hospital.-Champagne at
      the Eastern Hospital.-Fever and Small-Pox Hospitals.-Reopening of the West London
      Hospital.-Vacancies.-The Kensington District Nursing Association, etc., etc.

PMID- 29825019
TI  - Annotations: Wanted, L50,000.-Cottage Hospitals.-Lady Doctors and Nurses.-Teeth
      at the General and Special Hospitals.

PMID- 29825020
TI  - Employment for Epileptics.

PMID- 29825021
TI  - Alleged Cruelty of a Hospital Sister.

PMID- 29825022
TI  - The Best Colour for Sick-Room Walls.

PMID- 29825023
TI  - Hospital Promotion: A Wag's Experience.

PMID- 29825024
TI  - Children's Hospitals in England.

PMID- 29825025
TI  - The Modern Samaritan.

PMID- 29825027
TI  - Monotony.

PMID- 29825026
TI  - Notes and News: Miscellaneous Items.-The Baroness Burdett-Coutts and the Great
      Northern Central Hospital.-The East London Nursing Society.-Curious Hospital
      Incidents.-Vacancies.-The East London Hospital for Children.-The Royal London
      Ophthalmic Hospital.-The Bristol Children's Hospital.-Donations and Legacies to
      Medical Charities.-Children's Hospitals.-The North London Association for the
      Sick Poor, etc., etc.

PMID- 29825029
TI  - Nurses' Trials-Responsibility.

PMID- 29825028
TI  - Nursing in Workhouse Infirmaries.

PMID- 29825030
TI  - Nurse Farms, Hospitals, and Private Nursing Institutions: Miss Manson's Reply.

PMID- 29825031
TI  - In the Children's Ward: Chapter III.

PMID- 29825032
TI  - Incidents of Animal Life: Superstitions about Birds.

PMID- 29825033
TI  - Hospital Patients and Medical Students.

PMID- 29825034
TI  - Faintings and Fits.

PMID- 29825035
TI  - A Good Exchange.

PMID- 29825036
TI  - A National Pension Fund for Hospital Officials and Nurses.

PMID- 29825037
TI  - The Public and Its Physic.

PMID- 29825038
TI  - Annotations: Teeth and Their Guardians.-A Sane Woman in a Lunatic Asylum.-What Is
      a Physician?

PMID- 29825039
TI  - Jonah and the Whale: A True Shark Story.

PMID- 29825040
TI  - The Stomach.

PMID- 29825041
TI  - The Story of the Hospitals: The Central London Throat and Ear Hospital.

PMID- 29825042
TI  - A National Pension Fund for Hospital Officials and Nurses: The Views of
      Secretaries, Sisters, Nurses, and Others.

PMID- 29825043
TI  - Annotations: Newcastle Leads the Van.-Annuities for a Term of Years.-Chemists and
      Druggists.

PMID- 29825044
TI  - Nurses' Trials-Responsibility.

PMID- 29825045
TI  - Nurse Farms, Hospitals, and Private Nursing Institutions: The Views of Patients,
      Superintendents, and Private Nurses.

PMID- 29825047
TI  - Notes and News: Meeting of the Hospitals Association.-Lectures at the Midwives'
      Institute.-The West London Hospital.-The Hampstead Home Hospital.-Hospital
      Collecting-Box Thefts.-The Queen and the East-End Hospitals.-The City of London
      Lying-In Hospital.-Vacancies.-The Ashburton and Buckfastleigh Cottage Hospital.
      The Burnley Hospital.-Donations and Legacies to Medical Charities.-The Birmingham
      General Hospital.-Hospitals and the Jubilee Celebration, etc., etc.

PMID- 29825046
TI  - Mischievous Misstatements: A Word of Counsel to the City Companies.

PMID- 29825048
TI  - In the Children's Ward: Chapter II.

PMID- 29825049
TI  - A World of Babies.

PMID- 29825050
TI  - Nursing in Workhouse Infirmaries: Discussion on Miss Manson's Paper.

PMID- 29825051
TI  - Patience.

PMID- 29825052
TI  - Death.

PMID- 29825053
TI  - Chats about Medical Museums: No. II.

PMID- 29825054
TI  - Notes and News: Items.-Jubilee Commemorations.-The Mold Cottage Hospital.
      University College Hospital.-Hospital Enlargement.-Vacancies.-The Late Dr. R. E.
      Carrington.-Hospital Anecdotes.-The Brompton Cancer Hospital.-The London Dental
      Hospital.-Hospital Alms-Boxes.-Royal Hospital for Diseases of the Chest.
      Donations to Medical Charities.-A Newsvendor's Legacy, etc., etc.

PMID- 29825055
TI  - Nurse Marion's Romance.

PMID- 29825056
TI  - Persistence, Not Panic.

PMID- 29825058
TI  - Difficult Cases.

PMID- 29825057
TI  - Annotations: Faith Healing.-Alleged Inhumanity at Guy's.

PMID- 29825059
TI  - Nurse Farms, Hospitals, and Private Nursing Institutions.

PMID- 29825060
TI  - National Pension Fund for Hospital Officials and Nurses.

PMID- 29825062
TI  - Hospital and Institutional News.

PMID- 29825061
TI  - Round the Hospitals.

PMID- 29825064
TI  - Typhus and Other Pestilences.

PMID- 29825063
TI  - Some Human Lessons in War-Time: IV. Riches and Wealth. Their Limitations, Use,
      and Impotence.

PMID- 29825065
TI  - Life and Death: Some Human Lessons in War-Time: Suggestion and Faith.

PMID- 29825066
TI  - Suggested Isolation of Wounded Canadians.

PMID- 29825068
TI  - Report of the County Medical Officer of Health and School Medical Officer
      (L.C.C.) for 1915.

PMID- 29825067
TI  - British Hospital and Ambulance Work in France: Some Impressions of a Visit.

PMID- 29825070
TI  - Medical Science and Ethics in War.

PMID- 29825069
TI  - The College of Nursing, Limited: Constitution of the Scottish Board.

PMID- 29825071
TI  - Comfort versus Appearance.

PMID- 29825072
TI  - The British Hospitals Association: A New Departure during War-Time.

PMID- 29825073
TI  - British Hospital and Ambulance Work in France: Some Impressions of a Visit.

PMID- 29825074
TI  - Mental Nurses in Military Hospitals.

PMID- 29825075
TI  - War Savings Associations.

PMID- 29825076
TI  - Methods and Machines in Surgery.

PMID- 29825077
TI  - Some Human Lessons in War-Time: III. Childhood and the Children.

PMID- 29825079
TI  - A Visit of Inspection.

PMID- 29825078
TI  - Human Temperaments. XII.-The Philosopher.

PMID- 29825080
TI  - Hospital and Institutional News.

PMID- 29825081
TI  - Round the Hospitals.

PMID- 29825082
TI  - The Adventures of the "Berry Mission."

PMID- 29825083
TI  - The Inflammability of Flannelette: An Ex Parte Statement.

PMID- 29825085
TI  - Nurses' Leagues and Matrons' Letters.

PMID- 29825084
TI  - The Delineation of Internal Organs: A New Electrical Aid to Diagnosis and
      Treatment.

PMID- 29825086
TI  - Be Ready for Emergencies.

PMID- 29825087
TI  - Round the Hospitals.

PMID- 29825088
TI  - The Treatment and Control of Venereal Diseases: From the Standpoint of the
      Voluntary Hospitals.

PMID- 29825089
TI  - The Dreadnought and the Explosion.

PMID- 29825090
TI  - The Treatment of Delirium Tremens.

PMID- 29825091
TI  - Meeting in Dublin.

PMID- 29825092
TI  - The Report of the Medical Officer to the Local Government Board.

PMID- 29825093
TI  - Sanatorium Troubles.

PMID- 29825094
TI  - The Charge of Lay Control Demonstrably a Myth.

PMID- 29825095
TI  - The Depreciation of Institutional Investments.

PMID- 29825096
TI  - New Ideas in Obstetrics from America: Current Views on Caesarean Section.

PMID- 29825097
TI  - Hospital and Institutional News.

PMID- 29825098
TI  - The Explosion on January 19.

PMID- 29825099
TI  - An Unfortunate Controversy at Leeds.

PMID- 29825100
TI  - Lessening the Tedium of Hospital Life: The Birmingham System at Work.

PMID- 29825101
TI  - The Notification of Venereal Diseases.

PMID- 29825102
TI  - An Inspiring Address.

PMID- 29825104
TI  - Conditions of Registration Applicable during the Period of Grace to Existing
      Nurses.

PMID- 29825103
TI  - Hospital Policy in America: Problems of the Future.

PMID- 29825105
TI  - Hospital and Institutional News.

PMID- 29825106
TI  - District Nurses and Their Work.

PMID- 29825107
TI  - Round the Hospitals.

PMID- 29825108
TI  - Names and Things: The Universal Craving for Euphemisms.

PMID- 29825109
TI  - Parliament and the Profession.

PMID- 29825110
TI  - The West London Hospital.

PMID- 29825112
TI  - The Professional Fees of Physicians and Surgeons.

PMID- 29825111
TI  - The College of Nursing, Limited, and State Registration of Nurses.

PMID- 29825113
TI  - Moral: II. Factors in Its Destruction.

PMID- 29825114
TI  - Recent German Work on Tuberculosis.

PMID- 29825115
TI  - A State Asylum Service: A Change That Would Promote Efficiency.

PMID- 29825116
TI  - The Training of Hospital Matrons.

PMID- 29825118
TI  - Hospital and Institutional News.

PMID- 29825117
TI  - Some Zander Machines Described and Illustrated.

PMID- 29825119
TI  - Statistics of 109 London Hospitals in 1915.

PMID- 29825121
TI  - Decorations for Hospital Secretaries.

PMID- 29825120
TI  - Zander Mechanotherapy.

PMID- 29825122
TI  - Round the Hospitals.

PMID- 29825123
TI  - Peter Bent Brigham Hospital.

PMID- 29825125
TI  - Knighthoods for Hospital Secretaries.

PMID- 29825124
TI  - Sanatorium Buildings at L12 per Bed.

PMID- 29825126
TI  - The Refining of Crude Statistics.

PMID- 29825128
TI  - Parliament and the Profession.

PMID- 29825127
TI  - The Hospital and the Surgeon: II. Service and Administration.

PMID- 29825129
TI  - Poor-Law Institutions and Nurse-Training.

PMID- 29825130
TI  - Hospital and Institutional News.

PMID- 29825131
TI  - Round the Hospitals.

PMID- 29825132
TI  - Clairvoyance and the War.

PMID- 29825133
TI  - The Position of the Territorial Medical Officer.

PMID- 29825134
TI  - Malnutrition.

PMID- 29825136
TI  - Christmas in the Hospitals.

PMID- 29825135
TI  - Is There a Shortage in the Supply of Nurses?

PMID- 29825137
TI  - A Memorable Christmas Day.

PMID- 29825138
TI  - How Increases in Railway Fares Affect the Devonshire Hospital.

PMID- 29825139
TI  - The Responsibilities of Voluntary Hospitals.

PMID- 29825140
TI  - The Peter Bent Brigham Hospital, Boston.

PMID- 29825141
TI  - Macedonia in War-Time.

PMID- 29825143
TI  - Practitioners and Earning Power.

PMID- 29825142
TI  - Annual Meeting of Constituents.

PMID- 29825144
TI  - Hospital and Institutional News.

PMID- 29825145
TI  - Accident to Mr. A. W. Faire, Deputy-Lieutenant of Leicestershire.

PMID- 29825146
TI  - Patriotism of the Nurse-Training Schools: XI. War Work in Glasgow Institutions.

PMID- 29825147
TI  - Round the Hospitals.

PMID- 29825148
TI  - The Editor and His Readers.

PMID- 29825149
TI  - The School Doctor and the Compulsion of Parents.

PMID- 29825150
TI  - Royal Albert Edward Infirmary, Wigan.

PMID- 29825151
TI  - The Dispensary Chain in London.

PMID- 29825153
TI  - The Statement Issued by the Central Committee for State Registration in London:
      The Committee's Attitude Defined.

PMID- 29825152
TI  - Strong Protest by the Royal British Nurses' Association.

PMID- 29825155
TI  - Hospital Dietetics.

PMID- 29825154
TI  - Round the Hospitals.

PMID- 29825157
TI  - The Causation of Tabes and of General Paralysis: A New Observation from Fiji.

PMID- 29825156
TI  - Establishments for Massage or Special Treatment.

PMID- 29825159
TI  - The War Work of the M.O.H.

PMID- 29825158
TI  - Business of the Quarterly Court.

PMID- 29825160
TI  - A Group of London Medical Schools.

PMID- 29825161
TI  - A State Medical Service: More Kite-Flying.

PMID- 29825162
TI  - Hospital and Institutional News.

PMID- 29825163
TI  - The Will to Destroy: Mrs. Fenwick's and the Central Committee's Statement
      Examined.

PMID- 29825164
TI  - Trained Nurses and the Anglo-French Committee.

PMID- 29825166
TI  - Further Report of the Committee of Inquiry.

PMID- 29825165
TI  - The Hospital Dietary: II. Educational Aspects.

PMID- 29825168
TI  - Surprise Packets of Wartime.

PMID- 29825167
TI  - Parliament and the Profession.

PMID- 29825169
TI  - Sir Alfred Keogh, G.C.B., M.D.: The Director-General of the Army Medical Service.

PMID- 29825170
TI  - Patriotism in British Hospitals: Two London Medical Schools.

PMID- 29825171
TI  - The New Electrical Department at Guy's: A Veteran among Hospitals Keeping up to
      Date.

PMID- 29825172
TI  - New Regulations of the Secretary of State.

PMID- 29825174
TI  - Re-Education in Walking.

PMID- 29825173
TI  - On Guard in Wartime.

PMID- 29825175
TI  - Leicester and County Hospital Saturday Society.

PMID- 29825176
TI  - Hospital and Institutional News.

PMID- 29825178
TI  - An Eastern County Hospital's Preparations.

PMID- 29825177
TI  - How German Hospital Ships Are Fitted.

PMID- 29825180
TI  - The Medical Profession and the War.

PMID- 29825179
TI  - Further Questions and Answers.

PMID- 29825181
TI  - Round the Hospitals.

PMID- 29825182
TI  - Independent Audit of Asylum Accounts.

PMID- 29825183
TI  - The Matrons and the College.

PMID- 29825184
TI  - The Royal British College of Nursing.

PMID- 29825185
TI  - A School for Massage: Developments at Guy's Hospital.

PMID- 29825186
TI  - Naval Medicine in the Great War.

PMID- 29825187
TI  - Round the Hospitals.

PMID- 29825188
TI  - Cats as Carriers of Disease: Inflammation of the Eye from Infected Fur.

PMID- 29825189
TI  - Military Hospitals in India.

PMID- 29825190
TI  - The Mobilisation of the Medical Profession.

PMID- 29825191
TI  - Hospital and Institutional News.

PMID- 29825192
TI  - From across the Seas.

PMID- 29825193
TI  - The Russian Union of Zemstvos: A Fine Organisation for the Care of the Wounded.

PMID- 29825194
TI  - Money and Trusteeship.

PMID- 29825195
TI  - Parliament and the Profession.

PMID- 29825196
TI  - Some Observations of Bird Life.

PMID- 29825197
TI  - The Hospital Dietary: A Too Much Neglected Study.

PMID- 29825198
TI  - Round the Hospitals.

PMID- 29825199
TI  - Hospital and Institutional News.

PMID- 29825200
TI  - Report of the Medical Research Committee.

PMID- 29825201
TI  - The Treatment of Lunatics.

PMID- 29825202
TI  - Asylum Workers.

PMID- 29825203
TI  - Patients' Payments and Contributions.

PMID- 29825204
TI  - The School Doctor and Sex Education.

PMID- 29825205
TI  - The College of Nursing: A Call to Action.

PMID- 29825206
TI  - Gifts in Kind: Their Valuation in Hospital Accounts.

PMID- 29825207
TI  - Text of the Correspondence.

PMID- 29825209
TI  - Legal Notes for Institutional Workers.

PMID- 29825208
TI  - The Local Incidence of Infectious Diseases.

PMID- 29825211
TI  - Hospital Managers in Municipal Office.

PMID- 29825210
TI  - Parliament and the Profession.

PMID- 29825213
TI  - Moral: Its First Reinforcement.

PMID- 29825212
TI  - Patriotism and the Nurse-Training Schools: X. Leicester, Sheffield, Salisbury.

PMID- 29825214
TI  - The Future Is Youth's Freehold.

PMID- 29825215
TI  - Medical Degrees and Diplomas.

PMID- 29825217
TI  - Patients' Payments and Contributions.

PMID- 29825216
TI  - The Need for Businesslike Methods.

PMID- 29825218
TI  - Hospital and Institutional News.

PMID- 29825219
TI  - Round the Hospitals.

PMID- 29825221
TI  - Hospital and Institutional News.

PMID- 29825220
TI  - State Registration: The Central Committee and the College of Nursing.

PMID- 29825223
TI  - Human Temperaments. XIII.-The Suspicious Temperament.

PMID- 29825222
TI  - Patriotism and Nurse-Training Schools: IX. Royal Infirmary, Edinburgh.

PMID- 29825224
TI  - Some Human Lessons in War-Time: V. The Pleasures of Life.

PMID- 29825225
TI  - The American Hospital Association: Its Progress and Present Position.

PMID- 29825226
TI  - Round the Hospitals.

PMID- 29825227
TI  - Discharged Soldiers' Allowances.

PMID- 29825228
TI  - Mental Nurses in War Hospitals.

PMID- 29825230
TI  - The Great Extension at Leeds.

PMID- 29825229
TI  - OEdema and Anasarca: Some Overlooked Factors in Causation.

PMID- 29825231
TI  - A Notable Contest.

PMID- 29825232
TI  - Parliament and the Profession.

PMID- 29825234
TI  - Some Military Hospital Gazettes.

PMID- 29825233
TI  - The Future of School Medical Inspection.

PMID- 29825235
TI  - Parliament and the Profession.

PMID- 29825236
TI  - Philosophy in Hospital Architecture.

PMID- 29825238
TI  - Round the Hospitals.

PMID- 29825237
TI  - Military Hospital Construction.

PMID- 29825239
TI  - Poor-Law Institutions and Nurse-Training.

PMID- 29825240
TI  - The Peter Bent Hospital, Boston, Mass.

PMID- 29825242
TI  - The Selection of Hospital Staffs.

PMID- 29825241
TI  - Derbyshire Sanatorium, Walton, Chesterfield.

PMID- 29825244
TI  - The New Arbroath Infirmary.

PMID- 29825243
TI  - Hospital and Institutional News.

PMID- 29825245
TI  - Port Sunlight Cottage Hospital.

PMID- 29825246
TI  - The Hospital and the Surgeon: I. The Selection of the Staff.

PMID- 29825247
TI  - The District Nurse.

PMID- 29825248
TI  - Ham Green Hospital and Sanatorium, Bristol.

PMID- 29825249
TI  - Knighthoods for Hospital Secretaries.

PMID- 29825250
TI  - Military Hospital Construction.

PMID- 29825251
TI  - Leicester Royal Infirmary Children's Hospital.

PMID- 29825252
TI  - Some Human Lessons in War-Time: VI. When Life Is and Is Not a Failure.

PMID- 29825253
TI  - Surgeons, Hospitals, and Patients: The Road to Standardisation.

PMID- 29825255
TI  - Parliament and the Profession.

PMID- 29825254
TI  - Christmas in the Hospitals.

PMID- 29825256
TI  - Erratum.
AB  - [This corrects the article on p. 272 in vol. 61.].

PMID- 29825257
TI  - Erratum.
AB  - [This corrects the article on p. 255a in vol. 61.].

PMID- 29825258
TI  - The Nation and Its Nurses: Their Enemies' Tactics Are Identical.

PMID- 29825259
TI  - Professional Prospects and Anticipations.

PMID- 29825261
TI  - Round the Hospitals.

PMID- 29825260
TI  - Immoralities in Church Management.

PMID- 29825262
TI  - Hospital and Institutional News.

PMID- 29825263
TI  - Prevention and Arrest of Epidemic Disease in Wartime.

PMID- 29825265
TI  - The Final Report of the Committee of Inquiry.

PMID- 29825264
TI  - University of Birmingham.

PMID- 29825266
TI  - The Ethics of the New Criminal Law Amendment Bill.

PMID- 29825267
TI  - Hospital and Institutional News.

PMID- 29825268
TI  - Nursing Problems in Ireland.

PMID- 29825269
TI  - Round the Hospitals.

PMID- 29825270
TI  - Head-Mistresses and the Nurse.

PMID- 29825272
TI  - John Hunter and War Surgery.

PMID- 29825271
TI  - The Sanitation of Camps.

PMID- 29825273
TI  - St. Thomas's Hospital and the Victory Loan.

PMID- 29825274
TI  - Addenbrooke's Hospital, Cambridge.

PMID- 29825275
TI  - War Savings Associations: The Action of Two Great Hospitals.

PMID- 29825276
TI  - The Employment of Consumptives.

PMID- 29825278
TI  - Medical Home-Truths.-I.

PMID- 29825277
TI  - Some War Problems in Food: The Bread Ration.

PMID- 29825280
TI  - Round the Hospitals.

PMID- 29825279
TI  - The Problem of Repopulation.

PMID- 29825281
TI  - Professional Registrationists and Others.

PMID- 29825282
TI  - Manchester Royal Infirmary.

PMID- 29825283
TI  - Pinewood Sanatorium.

PMID- 29825284
TI  - Small-Pox and War: What Has Happened and May Happen Again.

PMID- 29825285
TI  - Compulsion for Medical Men?

PMID- 29825286
TI  - War's Effect on Relative Cost of London Hospitals.

PMID- 29825288
TI  - Maidenhead Cottage Hospital.

PMID- 29825287
TI  - Hospital and Institutional News.

PMID- 29825290
TI  - New Hospital for Women.

PMID- 29825289
TI  - Reform in Tuberculosis Work: I. The Sanatorium.

PMID- 29825291
TI  - Our Women, Warriors, and Workers.

PMID- 29825292
TI  - Sleeplessness: A Difficult Problem in Therapeutics.

PMID- 29825293
TI  - Industrial Efficiency and Eyesight.

PMID- 29825294
TI  - Annual Meeting at St. James's Palace.

PMID- 29825296
TI  - An Avoided Danger to Voluntary Hospitals.

PMID- 29825295
TI  - Report of the Convalescent Homes Committee.

PMID- 29825297
TI  - Round the Hospitals.

PMID- 29825298
TI  - Grants to Hospitals Recommended by the Distribution Committee.

PMID- 29825299
TI  - Distribution Meeting of the Governors and General Council: Increase in Awards of
      L30,000.

PMID- 29825300
TI  - Hospital and Institutional News.

PMID- 29825301
TI  - Report of the Distribution Committee.

PMID- 29825302
TI  - The Triumph of the Voluntary Principle.

PMID- 29825304
TI  - Round the Hospitals.

PMID- 29825303
TI  - Grants Recommended by the Convalescent Homes Committee.

PMID- 29825305
TI  - The "Mobilisation" of the Medical Profession.

PMID- 29825306
TI  - Important Meeting at Leeds: Large Funds Forthcoming.

PMID- 29825307
TI  - Reform in Tuberculosis Work: III. The Tuberculosis Officer.

PMID- 29825308
TI  - Hospital and Institutional News.

PMID- 29825309
TI  - How the London Hospital Organised and Suffered.

PMID- 29825311
TI  - The Johns Hopkins Hospital, Baltimore: Unique, up to Date, and Inspiring.

PMID- 29825310
TI  - The Explosion on January 19.

PMID- 29825312
TI  - The Royal British College of Nursing Born.

PMID- 29825313
TI  - Maternity and Child Welfare.

PMID- 29825314
TI  - Churches and Charity Funds.

PMID- 29825315
TI  - Deaths from Fire: Are Trained Nurses' Uniform Dangerous?

PMID- 29825316
TI  - Dishonesty in Testimonials.

PMID- 29825317
TI  - The Editor's Letter-Box.

PMID- 29825318
TI  - Enter the Royal British College of Nursing.

PMID- 29825320
TI  - Round the Hospitals.

PMID- 29825319
TI  - Churches and Charity Funds.

PMID- 29825321
TI  - The Rise of State Preventive Medicine.

PMID- 29825322
TI  - Pressing Need at the Front for Mufflers.

PMID- 29825323
TI  - The Remedy of Recognition an Imperative Duty.

PMID- 29825324
TI  - Hospital and Institutional News.

PMID- 29825325
TI  - Pension Problems.

PMID- 29825326
TI  - War, Alcohol, and Criminals.

PMID- 29825327
TI  - How Blinded Soldiers Are Cared for.

PMID- 29825328
TI  - The Problem of Population.

PMID- 29825329
TI  - Irish Local Government Boards and Disloyal Boards of Guardians.

PMID- 29825331
TI  - The Practice in the Free Churches.

PMID- 29825330
TI  - Reform in Tuberculosis Work: II. The Sanatorium.

PMID- 29825332
TI  - Churches and Charity Funds.

PMID- 29825333
TI  - Medical Home-Truths.-II. Medicine in General.

PMID- 29825335
TI  - St. Jude's Offertories.

PMID- 29825334
TI  - Legal Notes for Institutional Workers.

PMID- 29825336
TI  - Infant Mortality: Groping for a Safe Basis of Indubitable Fact.

PMID- 29825337
TI  - Round the Hospitals.

PMID- 29825338
TI  - Mr. Squealer the Rat-Catcher.

PMID- 29825339
TI  - Registration: Its Limitations and a Plan of Campaign.

PMID- 29825340
TI  - Venereal Diseases at Guy's Hospital: The Working of the New Scheme.

PMID- 29825342
TI  - The Royal College of British Nursing.

PMID- 29825341
TI  - The Training of Probationers.

PMID- 29825344
TI  - Poor-Law Nurses and the N.P.L.O.A.

PMID- 29825343
TI  - What Is Truth?

PMID- 29825346
TI  - The Report of the Unofficial Commission of Investigation.

PMID- 29825345
TI  - Parliament and the Profession.

PMID- 29825347
TI  - Hospital and Institutional News.

PMID- 29825348
TI  - Claim for Rebate of Spirit Duty.

PMID- 29825349
TI  - The National Poor-Law Officers' Association.

PMID- 29825350
TI  - The Brain Worker and His Food.

PMID- 29825352
TI  - The Hospital Spirit in National Affairs.

PMID- 29825351
TI  - The New Hospital for Women: Sir Alfred Keogh, K.C.B., on Its Jubilee and Value.

PMID- 29825353
TI  - The Eradication of Venereal Disease.

PMID- 29825354
TI  - Hospital Work in East Africa: Kikuyu and Limoru.

PMID- 29825355
TI  - General Charities.

PMID- 29825356
TI  - Humorous Medical Epitaphs.

PMID- 29825357
TI  - St. Thomas's Hospital.

PMID- 29825359
TI  - Hospitals under 150 Beds.

PMID- 29825358
TI  - How the Russian Red Cross Gets Its Wants Supplied.

PMID- 29825360
TI  - The Trials of a Hospital Physician.

PMID- 29825361
TI  - British and Foreign Sailors' Society.

PMID- 29825362
TI  - Hospitals with 150 Beds and Upwards.

PMID- 29825363
TI  - Hospital Music and Christmas Festivities.

PMID- 29825364
TI  - Round the Hospitals.

PMID- 29825365
TI  - Hospital and Institutional News.

PMID- 29825366
TI  - Earning Power in Women Workers: A Momentous Opportunity.

PMID- 29825367
TI  - Hospitals under 50 Beds.

PMID- 29825369
TI  - Compulsory Latin for Medical Students.

PMID- 29825368
TI  - Nature Studies in Macedonia.

PMID- 29825371
TI  - Christmas Number of the War Hospital Gazettes.

PMID- 29825370
TI  - Christmas in War-Time.

PMID- 29825373
TI  - Parliament and the Profession.

PMID- 29825372
TI  - First Eastern General Hospital (T), Cambridge.

PMID- 29825374
TI  - Awards for Valuable Services in Connection with the War.

PMID- 29825375
TI  - The College's Barometer of Progress: The Anti-College Party Steadily Loses
      Ground.

PMID- 29825377
TI  - The Nation's Food and the War.

PMID- 29825376
TI  - Round the Hospitals.

PMID- 29825379
TI  - Hospital and Institutional News.

PMID- 29825378
TI  - The Criminal Law Amendment Bill: State Recognition of Preventive Medicine.

PMID- 29825380
TI  - Children's Eyesight and the Cinematograph.

PMID- 29825381
TI  - Military Medicine at Waterloo.

PMID- 29825382
TI  - The Work of the Elizabeth Barclay Home of Industry.

PMID- 29825383
TI  - Unorganised: Its Difficulties and a Pernicious System.

PMID- 29825384
TI  - The Prevention of Venereal Disease.

PMID- 29825385
TI  - Hospitals and the Spirit Tax.

PMID- 29825386
TI  - The Royal British Nurses' Association and the College of Nursing, Limited.

PMID- 29825388
TI  - The Criminal Law Amendment Bill.

PMID- 29825387
TI  - The Profession of British Nurses: I. Plain Words on Registration.

PMID- 29825389
TI  - The Future Citizen.

PMID- 29825390
TI  - The "Runwell" Semi-Rotary Hand Pump.

PMID- 29825391
TI  - The Operative Treatment of Inguinal Hernia in Hospital.

PMID- 29825392
TI  - Manipulative Surgery.

PMID- 29825393
TI  - A Ministry of Health.

PMID- 29825395
TI  - Flies and Food: Grievous Dangers and How to Prevent Them.

PMID- 29825394
TI  - The Editor's Letter-Box.

PMID- 29825396
TI  - The Sugar Ration.

PMID- 29825397
TI  - The Patriotism of the Nurse-Training Schools: XII. London Training Schools.

PMID- 29825398
TI  - Emotion and Belief.

PMID- 29825400
TI  - What Is Truth?

PMID- 29825399
TI  - The Editor's Letter-Box.

PMID- 29825401
TI  - Round the Hospitals.

PMID- 29825402
TI  - Hospital and Institutional News.

PMID- 29825404
TI  - Round the Hospitals.

PMID- 29825403
TI  - The Editor's Letter-Box.

PMID- 29825406
TI  - Unveiling of Bas-Relief of Florence Nightingale.

PMID- 29825405
TI  - Nursing in Ireland: The Guinea-Pigs and the Mansion House Cat.

PMID- 29825407
TI  - Some Great Hospitals of America: British Types and New Departures.

PMID- 29825408
TI  - The New Call to the Medical Profession.

PMID- 29825409
TI  - Its Work, Its Ambitions, and Its Outlook.

PMID- 29825410
TI  - Great Britain and the United States.

PMID- 29825411
TI  - Hospital and Institutional News.

PMID- 29825412
TI  - The Pay Hospital System in Great Britain: It Should Become Widespread after the
      War.

PMID- 29825413
TI  - Where America Leads Great Britain.

PMID- 29825414
TI  - The Service of Dedication at St. Paul's: A Momentous Event in the World's
      History.

PMID- 29825415
TI  - America's Awakening to Hospital Values: The Spread of Efficiency.

PMID- 29825417
TI  - From across the Seas.

PMID- 29825416
TI  - Nursing Progress in America.

PMID- 29825418
TI  - The Irish Medical Association.

PMID- 29825419
TI  - Parliament and the Profession.

PMID- 29825420
TI  - Municipalities and the Voluntary Principle.

PMID- 29825421
TI  - The Editor's Letter-Box.

PMID- 29825422
TI  - Parliament and the Profession.

PMID- 29825423
TI  - Easter Day 1917: The Murder of Non-Combatants.

PMID- 29825424
TI  - Hospital and Institutional News.

PMID- 29825425
TI  - Disseminated Sclerosis: A Knotty Problem of Causation and Treatment.

PMID- 29825427
TI  - Leicester Royal Infirmary: A Largely Attended Annual Meeting.

PMID- 29825426
TI  - Nurses Boxing with Patients.

PMID- 29825428
TI  - Round the Hospitals.

PMID- 29825429
TI  - Two Sorts of Waste of Children.

PMID- 29825430
TI  - The Operative Treatment of Inguinal Hernia in Hospital.

PMID- 29825432
TI  - The Profession of British Nurses: II. Plain Words on Registration.

PMID- 29825431
TI  - Manipulative Surgery.

PMID- 29825433
TI  - A Foreword, with Some Hospital Reminiscences.

PMID- 29825434
TI  - Hospital and Institutional News.

PMID- 29825435
TI  - An Attack on the Army Medical Service.

PMID- 29825436
TI  - Voluntary Hospital Finance: I. Some Reflections and a Foreword.

PMID- 29825437
TI  - The Profession of British Nurses: Plain Words on Registration.-IV.

PMID- 29825438
TI  - Pain and Shock.

PMID- 29825439
TI  - The Royal Hospital for Incurables, Putney.

PMID- 29825440
TI  - War and Eugenics: A Paroxysm of Paradox.

PMID- 29825441
TI  - Legal Notes for Institutional Workers.

PMID- 29825442
TI  - Bread as the Staple Food.

PMID- 29825444
TI  - A Ministry of Health.

PMID- 29825443
TI  - Manipulative Surgery.

PMID- 29825446
TI  - The Guild of Social Workers.

PMID- 29825445
TI  - Noble Women Workers in the War.

PMID- 29825447
TI  - Labour-Saving Appliances.

PMID- 29825448
TI  - The Patriotism of the Nurse-Training Schools: XIII. Some Lancashire Institutions.

PMID- 29825449
TI  - The Profession of British Nurses: Plain Words on Registration.-III.

PMID- 29825451
TI  - From Across the Seas.

PMID- 29825450
TI  - Summer Knitting.

PMID- 29825452
TI  - Leeds General Infirmary Extensions.

PMID- 29825453
TI  - Medical Research in India.

PMID- 29825454
TI  - Recent Work on Artificial Pneumothorax: Benefits and Their Limitations.

PMID- 29825455
TI  - The Easter Bank Holiday, 1917.

PMID- 29825457
TI  - The Uniting of the Nations: Will Britons in the Homeland Awake and Act?

PMID- 29825456
TI  - Parliament and the Profession.

PMID- 29825458
TI  - Guardians and Economy.

PMID- 29825459
TI  - Hospital and Institutional News.

PMID- 29825460
TI  - Round the Hospitals.

PMID- 29825461
TI  - The Necessity for Amending Legislation.

PMID- 29825462
TI  - The Surgery of Military Spinal Injuries: Some Indications for Its Employment.

PMID- 29825463
TI  - The Fabian Report on Professional Associations.

PMID- 29825464
TI  - The Medical Profession and the Uncertified Midwife.

PMID- 29825465
TI  - Hospital and Institutional News.

PMID- 29825467
TI  - The Preliminary Training School for Nurses. II. Some Early and Later Experiences.

PMID- 29825466
TI  - Parliament and the Profession.

PMID- 29825469
TI  - Round the Hospitals.

PMID- 29825468
TI  - The General Medical Council and the Supply of Doctors.

PMID- 29825471
TI  - Memorandum by the Council on the Petition to the Prime Minister.

PMID- 29825470
TI  - Occupational Therapy.

PMID- 29825472
TI  - Hospital Chapels and Hospital Sunday.

PMID- 29825473
TI  - Round the Hospitals.

PMID- 29825475
TI  - Life in a Korean Hospital: A Medical Mission in the East.

PMID- 29825474
TI  - The Church's Attitude Towards Disease.

PMID- 29825477
TI  - 1916.-A Year's Work in the Hospitals and Medical Charities of London.

PMID- 29825476
TI  - A Single Year's Roll-Call of the Sick.

PMID- 29825478
TI  - The Chapel of Guy's Hospital.

PMID- 29825479
TI  - Hospitals and Their Special Needs.

PMID- 29825480
TI  - The Churches' Opportunity: Hospital Sunday, 1917.

PMID- 29825481
TI  - Poor-Law Nursing in England. Poor-Law Nursing To-Day.-II.

PMID- 29825482
TI  - Resignation of Mr. J. G. Wainwright, the Treasurer.

PMID- 29825483
TI  - Hospital and Institutional News.

PMID- 29825485
TI  - Science and Pseudo-Science: The Hereditary Criminal Again?

PMID- 29825484
TI  - M.A.B. Economy: Its Excellent Results.

PMID- 29825486
TI  - National Insurance and the Proposed Ministry of Health.

PMID- 29825487
TI  - Parliament and the Profession.

PMID- 29825488
TI  - Mens Sana in Corpore Sano.

PMID- 29825489
TI  - Plain Words on Registration.-V.

PMID- 29825490
TI  - Round the Hospitals.

PMID- 29825491
TI  - Child Mortality and Child Welfare.

PMID- 29825492
TI  - The Doctor's Vade-Mecum: Simple Rules for Medical Practitioners.

PMID- 29825493
TI  - The Medical Profession and Legislation against Contraceptives.

PMID- 29825495
TI  - The Patriotism of the Nurse-Training Schools: XIV. Some Yorkshire Institutions.

PMID- 29825494
TI  - Hospital and Institutional News.

PMID- 29825497
TI  - The Work of Hospital Almoners-III: Address by Miss Cummins at the London School
      of Economics.

PMID- 29825496
TI  - Hospital Pharmacists and Food Economy.

PMID- 29825498
TI  - Subacute Endocarditis in Children.

PMID- 29825499
TI  - The Worst War of the World: I. Its Teachings and Momentous Issues.

PMID- 29825500
TI  - Three Plays with a Purpose.

PMID- 29825502
TI  - The B.M.A. Annual Representative Meeting.

PMID- 29825501
TI  - Hospital and Institutional News.

PMID- 29825504
TI  - Leicester Royal Infirmary.

PMID- 29825503
TI  - The College of British Nursing.

PMID- 29825505
TI  - The War Cripple: His Restoration, Occupations, and Future.

PMID- 29825506
TI  - Round the Hospitals.

PMID- 29825507
TI  - National Health Work for Women.

PMID- 29825508
TI  - The Responsibility of the Anaesthetist.

PMID- 29825509
TI  - Parliament and the Profession.

PMID- 29825510
TI  - Recuperative Hostels.

PMID- 29825511
TI  - The Revised Pension Arrangements, and a New Act.

PMID- 29825512
TI  - Industrial Efficiency and Fatigue: Overwork and Overstrain.

PMID- 29825514
TI  - Recuperative Hostels: Has the Law Been Violated?

PMID- 29825513
TI  - Baby Week.

PMID- 29825516
TI  - Centralisation versus Decentralisation: How to Fight Tuberculosis.

PMID- 29825515
TI  - A Fall in Infant Mortality.

PMID- 29825517
TI  - Report of the Highlands and Islands Medical Service Board.

PMID- 29825519
TI  - Round the Hospitals.

PMID- 29825518
TI  - The Editor's Letter-Box.

PMID- 29825520
TI  - The Foodstuffs Advisory Board Specimen Menu.

PMID- 29825521
TI  - Hospital and Institutional News.

PMID- 29825522
TI  - Poor-Law Nursing in England: I. Sixty Years of Its History.

PMID- 29825523
TI  - The Recreation Rooms.

PMID- 29825524
TI  - The Fruits of "The Hospital's" Teaching.

PMID- 29825525
TI  - Round the Hospitals.

PMID- 29825526
TI  - Guy's Hospital and the Calling-Up of Doctors: Correspondence with the Local
      Government Board.

PMID- 29825528
TI  - The Second Annual Report of the Council.

PMID- 29825527
TI  - The Position of British Nursing.

PMID- 29825530
TI  - St. Thomas's Hospital. An Historic Group.

PMID- 29825529
TI  - Blood Investigations in Flying Men.

PMID- 29825531
TI  - Physical Exercises from a National Standpoint.

PMID- 29825532
TI  - British Nurses and Nursing. A Campaign of Misrepresentation and Personal
      Ambitions.

PMID- 29825533
TI  - Concerning Woman Suffrage.

PMID- 29825534
TI  - The Mesopotamia Commission Report.

PMID- 29825535
TI  - Hospital and Institutional News.

PMID- 29825536
TI  - The I.C.A.A. as a Clearing House.

PMID- 29825537
TI  - Venereal Disease in Scotland: The Trend of Progress in Treatment.

PMID- 29825538
TI  - Round the Hospitals.

PMID- 29825540
TI  - Miss Matheson Speaks at Belfast.

PMID- 29825539
TI  - Parliament and the Profession.

PMID- 29825541
TI  - The Law Society and Solicitors' Touts.

PMID- 29825542
TI  - Rotten Food for Londoners, Why?

PMID- 29825543
TI  - Hospital and Institutional News.

PMID- 29825545
TI  - The Leicester Home for Neurasthenic Soldiers.

PMID- 29825544
TI  - Recruiting by the New Method: Civilian Doctors to Replace Military Officers.

PMID- 29825547
TI  - Medical Politics.

PMID- 29825546
TI  - German Medical Officers for Prisoners' Camps?

PMID- 29825548
TI  - Children's Country Holidays Fund.

PMID- 29825549
TI  - Nursing Affairs in Ireland.

PMID- 29825550
TI  - Matrons in Council: Sparks from a Nurse's Anvil.

PMID- 29825551
TI  - Bird Life in Macedonia.

PMID- 29825552
TI  - Hospital and Institutional News.

PMID- 29825553
TI  - The Consumption of Beer.

PMID- 29825554
TI  - Twenty Years' Progress of a Great Charity.

PMID- 29825555
TI  - A War Emergency Benevolent Fund.

PMID- 29825556
TI  - Legal Notes for Institutional Workers.

PMID- 29825557
TI  - The Uniform of the British Nurse.

PMID- 29825558
TI  - The Problem of the Midwife.

PMID- 29825559
TI  - Help for Our Sailors: The Mansion House Meeting.

PMID- 29825561
TI  - The Work of Hospital Almoners: Address by Miss Cummins at the London School of
      Economics.

PMID- 29825560
TI  - The Illegitimate Child.

PMID- 29825562
TI  - Every Landsman's Duty and Opportunity.

PMID- 29825564
TI  - Round the Hospitals.

PMID- 29825563
TI  - How to Raise Birth-Rates after the War: Interesting Figures and Sober Facts.

PMID- 29825565
TI  - The Select Committee on the Medical Examination of Recruits: Some Notes on the
      Evidence.

PMID- 29825566
TI  - Annual Meeting of Governors and General Council.

PMID- 29825568
TI  - Optimism and Pessimism.

PMID- 29825567
TI  - Round the Hospitals.

PMID- 29825570
TI  - The College of Nursing, Limited.

PMID- 29825569
TI  - Proposed Diploma for Irish Nurses.

PMID- 29825571
TI  - A Medical Aspect of the Education Proposal: By a Tuberculosis Worker.

PMID- 29825572
TI  - Children's Country Holidays Fund.

PMID- 29825574
TI  - The Medical Profession and the War Office.

PMID- 29825573
TI  - Parliament and the Profession.

PMID- 29825575
TI  - The Problem of Substitutes.

PMID- 29825576
TI  - Hospital and Institutional News.

PMID- 29825578
TI  - The Nation's Fund for Nurses.

PMID- 29825577
TI  - The Great Concert and Two Important Speeches.

PMID- 29825579
TI  - Institutional Needs.

PMID- 29825580
TI  - Plastic Surgery.

PMID- 29825581
TI  - The Parent: Supported or Supplanted.

PMID- 29825582
TI  - A Kitchen Committee.

PMID- 29825583
TI  - The Preliminary Training School for Nurses: III. The Week's Work.

PMID- 29825584
TI  - The War and the Future of Poor-Law Infirmaries.

PMID- 29825586
TI  - Birthday Honours.

PMID- 29825585
TI  - The National Clean Milk Society's Investigation.

PMID- 29825588
TI  - The Prevention of Venereal Disease.

PMID- 29825587
TI  - Round the Hospitals.

PMID- 29825590
TI  - The Case against the Voluntary Hospital.

PMID- 29825589
TI  - A "Hut" Hospital: How the 3rd London General Hospital Came into Being.

PMID- 29825591
TI  - Mothercraft and Child Welfare: Maternity as State Service.

PMID- 29825592
TI  - Hospital and Institutional News.

PMID- 29825593
TI  - Quarterly Report of the House Committee.

PMID- 29825594
TI  - The Venereal Clinics of the Seamen's Hospital Society.

PMID- 29825596
TI  - Recuperative Hostels: The Hankering after Euphemisms.

PMID- 29825595
TI  - The Working Boy.

PMID- 29825597
TI  - The Criminal Law Amendment Bill.

PMID- 29825598
TI  - Co-Operation of City Corporation and Freemen.

PMID- 29825599
TI  - The Nethern Asylum.

PMID- 29825600
TI  - The Part and the Whole.

PMID- 29825602
TI  - Parliament and the Profession.

PMID- 29825601
TI  - Hospital and Institutional News.

PMID- 29825603
TI  - French Anti-Tuberculosis Measures.

PMID- 29825604
TI  - From across the Seas.

PMID- 29825605
TI  - A New Patent Electrolyser.

PMID- 29825606
TI  - Round the Hospitals.

PMID- 29825608
TI  - Plain Words on Registration.-VI.

PMID- 29825607
TI  - A Conflict of Opinion.

PMID- 29825609
TI  - The Cost of War Rations.

PMID- 29825610
TI  - The Service at Westminster Abbey.

PMID- 29825612
TI  - Addenbrooke's Hospital, Cambridge.

PMID- 29825611
TI  - Round the Hospitals.

PMID- 29825613
TI  - The Irish Anti-College Scheme.

PMID- 29825614
TI  - Soldiers' Heart: A Question of AEtiology.

PMID- 29825615
TI  - The Naval M.O. in Action.

PMID- 29825617
TI  - Personal Rights and the Criminal Law Amendment Bill.

PMID- 29825616
TI  - Warrior Patients in Hospitals: Their Temperatures and Maladies.

PMID- 29825618
TI  - Hospital and Institutional News.

PMID- 29825619
TI  - The Anti-Venereal Campaign: The Annual Oration before the Medical Society.

PMID- 29825620
TI  - The New Education and Its Teachers.

PMID- 29825621
TI  - The Supply of Doctors.

PMID- 29825623
TI  - Liverpool Royal Infirmary.

PMID- 29825622
TI  - The Preliminary Training School for Nurses: I. Its Uses and Developments.

PMID- 29825624
TI  - Criminals Are Made, Not Born.

PMID- 29825625
TI  - Parliament and the Profession.

PMID- 29825627
TI  - The Worst War of the World: II. Its Third Anniversary in Westminster Abbey.

PMID- 29825626
TI  - Matrons in Council.-Some Return Sparks: A Matron's View.

PMID- 29825628
TI  - Awards Recommended by the Committee of Distribution for the Year 1917.

PMID- 29825629
TI  - Essential Defects of the Theatre and Cinema.

PMID- 29825631
TI  - The Payment of Medical Officers in V.A.D. Hospitals.

PMID- 29825630
TI  - Hospital and Institutional News.

PMID- 29825632
TI  - The Hygiene of Play.

PMID- 29825633
TI  - Round the Hospitals.

PMID- 29825635
TI  - The Abbey Service.

PMID- 29825634
TI  - A Grave National Deficiency.-I.

PMID- 29825636
TI  - What Is Rat-Bite Fever?

PMID- 29825637
TI  - The New Offensive against Disease: King Edward VII.'s Hospital, Cardiff.

PMID- 29825638
TI  - Parliament and the Doctors.

PMID- 29825639
TI  - The Crusade against Venereal Disease: Addresses by Surg.-General Sir Alfred Keogh
      and Mrs. Creighton.

PMID- 29825640
TI  - Neurasthenia and the Army.

PMID- 29825641
TI  - Parliament and the Profession.

PMID- 29825642
TI  - Hospital and Institutional News.

PMID- 29825643
TI  - When the Wounded Arrive.

PMID- 29825644
TI  - Round the Hospitals.

PMID- 29825645
TI  - Poor-Law Nursing in England. III. The Sick Wards.

PMID- 29825646
TI  - Report on the Physical Welfare of Women and Children.

PMID- 29825647
TI  - The Hon. Arthur Stanley, C.B., M.V.O., M.P., Appointed Treasurer.

PMID- 29825648
TI  - Summer Knitting.

PMID- 29825649
TI  - The Chapel of Guy's Hospital.

PMID- 29825650
TI  - A London Holiday for Hospital Men.

PMID- 29825651
TI  - The Royal Infirmary and Our Prisoners in Germany: An Example Which Might Be
      Followed.

PMID- 29825653
TI  - The Second Annual General Meeting.

PMID- 29825652
TI  - Blind, Deaf, Defective, and Epileptic Children: Their Education and Training.

PMID- 29825654
TI  - The Work of Hospital Almoners-II: Address by Miss Cummins at the London School of
      Economics.

PMID- 29825655
TI  - Asylum Workers' Union.

PMID- 29825656
TI  - Has Cotton Grass a Commercial Value?

PMID- 29825657
TI  - The Future of Medical Benefit.

PMID- 29825658
TI  - Hospital and Institutional News.

PMID- 29825659
TI  - Are Baby Shows Vulgar and Valueless?

PMID- 29825661
TI  - Parliamentary Inquiry on the Medical Examination of Recruits: Some Lay Evidence.

PMID- 29825660
TI  - The Profession, the Public, and the Politicians.

PMID- 29825662
TI  - Round the Hospitals.

PMID- 29825663
TI  - Dr. Mercier and Sir Oliver Lodge.

PMID- 29825664
TI  - Institutional Needs.

PMID- 29825665
TI  - Nurse Democrats Voice Their Problems. Important Questions and Clear Answers.

PMID- 29825666
TI  - From across the Seas.

PMID- 29825667
TI  - Round the Hospitals.

PMID- 29825668
TI  - Addenbrooke's Hospital, Cambridge.

PMID- 29825669
TI  - The Strain of War on the Nervous System: Efficiency in Politicians and Soldiers.

PMID- 29825671
TI  - London as a Health Centre: By a Social Worker.

PMID- 29825670
TI  - A Vital Question for Some Voluntary Hospitals.

PMID- 29825672
TI  - Hospital and Institutional News.

PMID- 29825673
TI  - Matron's in Council: IV. The Love and Sympathy of a Noble Woman.

PMID- 29825675
TI  - A Jungle Hospital: The Travelling Dispensary Officer's Work.-I.

PMID- 29825674
TI  - A Rejoinder to "An Old Shoe's" Thoughts.

PMID- 29825677
TI  - Institutional Appliances.

PMID- 29825676
TI  - A Hospital Dispute in Tasmania.

PMID- 29825678
TI  - Parliament and the Profession.

PMID- 29825679
TI  - Round the Hospitals.

PMID- 29825680
TI  - The War Office and the Medical Profession.

PMID- 29825681
TI  - Matrons in Council: VII the Future of the Nursing Profession.

PMID- 29825682
TI  - Auxiliary Hospitals and Their Uses.

PMID- 29825683
TI  - Hospital and Institutional News.

PMID- 29825684
TI  - Medical Officers and the Supply of Drugs.

PMID- 29825685
TI  - Nature Studies in Macedonia-II.

PMID- 29825686
TI  - German Genius and Methods: Is Their Reputation Justified by Their Real Worth?

PMID- 29825687
TI  - How the Problem Of the Blind Can Be Solved: The Report of the Departmental
      Committee.

PMID- 29825688
TI  - A State of Unrest. A New Movement on Foot.

PMID- 29825690
TI  - New Board of Trade Rules.

PMID- 29825689
TI  - Communal Cookery: A New Opportunity for Educated Women.

PMID- 29825692
TI  - Nerve-Shattered Soldiers and Their Treatment: Dr. Lumsden's Excellent Scheme.

PMID- 29825691
TI  - The Catgut Ligature: A Technique for Its Use in Civil Practice.

PMID- 29825693
TI  - The Y.M.C.A. Anti-Tuberculosis Campaign: An Educational Biograph Film.

PMID- 29825694
TI  - The Bath Case and Its Lessons.

PMID- 29825696
TI  - Hospital and Institutional News.

PMID- 29825695
TI  - Air-Raids on Hospitals and Non-Combatants.

PMID- 29825697
TI  - The Question of Economics.

PMID- 29825698
TI  - Far-Reaching War Activities.

PMID- 29825699
TI  - Round the Hospitals.

PMID- 29825700
TI  - A Children's Hospital in Difficulties.

PMID- 29825701
TI  - The British Nursing Profession: The Two Voices.

PMID- 29825702
TI  - The Theatre and the Cinema: Some Hygienic Defects, Their Causes and Prevention.

PMID- 29825703
TI  - A Campaign for Food Economy.

PMID- 29825704
TI  - Education and National Morality.

PMID- 29825705
TI  - Asylum Treatment: What Is the Explanation?

PMID- 29825706
TI  - Matrons in Council: VI. Modern Ideas Needed, Though Not Favoured in Our
      Hospitals.

PMID- 29825707
TI  - A Plea for Raising War Office Payments with a Flat Rate.

PMID- 29825708
TI  - The Worst War of the World: III. The United States Troops Visit London.

PMID- 29825709
TI  - The Exhaustion of the Medical Profession.

PMID- 29825710
TI  - The Work of the Metropolitan Asylums Board.

PMID- 29825711
TI  - The Oldest Coroner in England.

PMID- 29825712
TI  - Nursing Affairs in Ireland.

PMID- 29825713
TI  - Sir Alfred Keogh and the R.A.M.C.

PMID- 29825714
TI  - Colonel Bruce Vaughan Has a Good Time.

PMID- 29825715
TI  - Hospital and Institutional News.

PMID- 29825716
TI  - Some History and Its Teachings.

PMID- 29825717
TI  - No State Licence Given to Murder.

PMID- 29825718
TI  - Round the Hospitals.

PMID- 29825719
TI  - Matrons in Council: III. From an Old Shoe.

PMID- 29825720
TI  - Nature Studies in Macedonia.

PMID- 29825721
TI  - What the Fighting Man Thinks of War.

PMID- 29825722
TI  - II-A Grave National Deficiency.

PMID- 29825723
TI  - Round the Hospitals.

PMID- 29825724
TI  - The Disinfection of Sick-Rooms.

PMID- 29825725
TI  - Parliament and the Profession.

PMID- 29825726
TI  - The Main Irish Grievance-Economic.

PMID- 29825727
TI  - Physical Methods in Deformity and Disease: Some Hindrances to Their More Extended
      Employment.

PMID- 29825728
TI  - A Jungle Hospital: II. Causes of Plague, Former Residencies, and Some Sport.

PMID- 29825729
TI  - The Army Medical Service Inquiry.

PMID- 29825730
TI  - The Worst War of the World: IV. The Germans' Barbarities and the World's Press.

PMID- 29825732
TI  - Many Honours for Hospital Workers.

PMID- 29825731
TI  - Rational Economy.

PMID- 29825733
TI  - Physical Orthopaedics.

PMID- 29825734
TI  - Matrons in Council: V. The Elements Must Be in the Woman.

PMID- 29825735
TI  - Hospital and Institutional News.

PMID- 29825737
TI  - Round the Hospitals.

PMID- 29825736
TI  - The Society of Women Journalists.

PMID- 29825738
TI  - The After-Care of Consumptives: The Economy of Developing Existing Institutions.

PMID- 29825739
TI  - Matrons in Council: VIII. An All-Round View of Reconstruction.

PMID- 29825740
TI  - Give the College a Chance.

PMID- 29825741
TI  - C.N.A. Nurses and the "Roll of Merit".

PMID- 29825742
TI  - Sweaters and Other Comforts.

PMID- 29825743
TI  - Civilian Practitioners and Military Hospitals.

PMID- 29825744
TI  - The Destruction of Medical Certificates.

PMID- 29825745
TI  - Efficiency and Individual Freedom.

PMID- 29825746
TI  - Smoking in Hospital.

PMID- 29825747
TI  - The Institution Food Controller.

PMID- 29825748
TI  - Hospital and Institutional News.

PMID- 29825749
TI  - Meat Inspection: A Department of Preventive Medicine.

PMID- 29825750
TI  - National Insurance and the Local Government Board.

PMID- 29825751
TI  - The English Conjoint Course.

PMID- 29825752
TI  - His Majesty's Visit. Many Difficulties Overcome.

PMID- 29825753
TI  - The True Line of Medical Progress.

PMID- 29825754
TI  - The Public Services.

PMID- 29825755
TI  - Its Claims and Advantages.

PMID- 29825756
TI  - Oxford University Course.

PMID- 29825757
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29825758
TI  - Dentistry as a Profession: Its Drawbacks and Preparations to Qualify.

PMID- 29825759
TI  - The Medical Schools of the United Kingdom.

PMID- 29825760
TI  - The Difficulties of the Schools.

PMID- 29825761
TI  - How Matters Stand To-Day.

PMID- 29825762
TI  - Qualification and Registration.

PMID- 29825763
TI  - The Irish Nursing Board.

PMID- 29825764
TI  - The Public Health Services: Their Attraction for Practitioners.

PMID- 29825765
TI  - Woman's Work in Medicine after the War: Memory Pictures and the Worker.

PMID- 29825766
TI  - Tropical Medicine.

PMID- 29825768
TI  - Medical Education in the Time of the Great War.

PMID- 29825767
TI  - Graduate Study in London Special Hospitals.

PMID- 29825769
TI  - Cambridge University Course.

PMID- 29825770
TI  - The Spoken Word and the Printed Page.

PMID- 29825772
TI  - Graduate Institutions in London.

PMID- 29825771
TI  - London University Course.

PMID- 29825774
TI  - Qualifications and Regulations.

PMID- 29825773
TI  - Higher Diplomas.

PMID- 29825775
TI  - The Food and Nutritional Diseases of an Army: How the British Soldier Is Cared
      for.

PMID- 29825776
TI  - Commandeered Hospitals: the Question of Compensation.

PMID- 29825777
TI  - The Nightingale School and St. Thomas's Hospital -III.

PMID- 29825778
TI  - The Hospital.

PMID- 29825780
TI  - Their Influence upon Methods of Amputation.

PMID- 29825779
TI  - Mental and Muscular Work in Relation to Food.

PMID- 29825781
TI  - Hospital and Institutional News.

PMID- 29825782
TI  - Irish Nurses' League.

PMID- 29825783
TI  - Round the Hospitals.

PMID- 29825784
TI  - Decorations and Titular Honours: Some New Developments and Their Relation to the
      Hospital World.

PMID- 29825785
TI  - Village Practice: An Autobiographical Fragment.

PMID- 29825786
TI  - Parliament and the Profession.

PMID- 29825787
TI  - The Midwives Bill.

PMID- 29825788
TI  - School Attendance and Health.

PMID- 29825789
TI  - The Homeland in War-Time.

PMID- 29825791
TI  - Cleanliness in Public Buildings.

PMID- 29825790
TI  - The R.B.N.A. and the College.

PMID- 29825793
TI  - Rations and Health.

PMID- 29825792
TI  - Tetanus in Civilian Practice.

PMID- 29825794
TI  - Hospital and Institutional News.

PMID- 29825795
TI  - Parliament and the Profession.

PMID- 29825797
TI  - Lord Lister: II. The Lessons of His Early Life.

PMID- 29825796
TI  - Myalgia: A Clinical Study.

PMID- 29825798
TI  - Treatment of Disabled Sailors and Soldiers.

PMID- 29825799
TI  - Treatment of Disabled Sailors and Soldiers.

PMID- 29825801
TI  - The Hospital.

PMID- 29825800
TI  - Sister Children's.

PMID- 29825802
TI  - Massage: A Branch of Physical Treatment: Its Principles and Its Value.

PMID- 29825803
TI  - Nursing Progress and Its Developments: VII. The Probationer's Third Year.

PMID- 29825804
TI  - Round the Hospitals.

PMID- 29825805
TI  - King George's Fund for Sailors.

PMID- 29825806
TI  - Victories of the Doctor and the Sanitarian.

PMID- 29825807
TI  - Hospital and Institutional News.

PMID- 29825808
TI  - Reredos in King's College Hospital Chapel.

PMID- 29825809
TI  - The Causes of Disease.

PMID- 29825810
TI  - From across the Seas.

PMID- 29825811
TI  - The Value of Registration.

PMID- 29825812
TI  - The Nightingale School and St. Thomas's Hospital-II.

PMID- 29825814
TI  - Facts for Food Economists.

PMID- 29825813
TI  - The R.B.N.A. and the College.

PMID- 29825815
TI  - Round the Hospitals.

PMID- 29825816
TI  - The Hospital.

PMID- 29825817
TI  - King George's Fund for Sailors.

PMID- 29825818
TI  - War Emergency Medicines.

PMID- 29825819
TI  - Parliament and the Profession.

PMID- 29825820
TI  - Treatment of War Pensioners and Other.

PMID- 29825821
TI  - The Physical Side of Social Regeneration.

PMID- 29825822
TI  - Education and Examination.

PMID- 29825824
TI  - The New Year, 1918: What to Read and Study.

PMID- 29825823
TI  - The Hospital.

PMID- 29825826
TI  - Round the Hospitals.

PMID- 29825825
TI  - The League of Mercy: Eighteenth Annual Meeting of Presidents.

PMID- 29825828
TI  - Parliament and the Profession.

PMID- 29825827
TI  - The Worst War of the World: An Enduring Commemoration. Our Old Army and Our First
      Defence.

PMID- 29825830
TI  - Once a Ward in Middlesex Hospital.

PMID- 29825829
TI  - Hospital and Institutional News.

PMID- 29825831
TI  - Prospects and Promises.

PMID- 29825832
TI  - Metropolitan Hospital Sunday Fund: Annual Meeting of Constituents: L76,354
      Distributed.

PMID- 29825834
TI  - Memorials to Hospital Worthies.

PMID- 29825833
TI  - "Raising a Ghost It Were Better to Lay".

PMID- 29825835
TI  - British Nursing Advancing: What "British Women's Hospital" Stands for.

PMID- 29825837
TI  - Parliament and the Profession.

PMID- 29825836
TI  - War Questions-Payments for Hospital Patients.

PMID- 29825839
TI  - Hospital Treatment for Wounded and Pensioned Soldiers.

PMID- 29825838
TI  - A Plea for Action Based on Knowledge.

PMID- 29825840
TI  - Hospital and Institutional News.

PMID- 29825841
TI  - The Irish Board of the College of Nursing.

PMID- 29825842
TI  - The Hospital.

PMID- 29825843
TI  - Report of the Medical Department of the Board of Education.

PMID- 29825844
TI  - Round the Hospitals.

PMID- 29825845
TI  - "Refusal to Attend Chapel": The Home's Reply.

PMID- 29825846
TI  - Generalism and Specialism.

PMID- 29825847
TI  - Hospital and Institutional News.

PMID- 29825848
TI  - The Hospital.

PMID- 29825849
TI  - Round the Hospitals.

PMID- 29825850
TI  - Unqualified Medical Practice: Should It Be Suppressed by Law?

PMID- 29825851
TI  - Two Types of Medical Leader: I. The Hero.

PMID- 29825852
TI  - The Position of the Smaller Institutions.

PMID- 29825853
TI  - "A Children's Hospital in Difficulties".

PMID- 29825854
TI  - For Irish Sailors and Soldiers Who Have Lost a Limb.

PMID- 29825855
TI  - Medical Controversies.

PMID- 29825857
TI  - The Combined Scheme of Two Well-Known Hospitals.

PMID- 29825858
TI  - The Organisation of the Leicester Saturday Society.

PMID- 29825856
TI  - Matrons in Council: IX. Some Criticisms Examined. Needs of the Future.

PMID- 29825859
TI  - Creche or Nursery School?

PMID- 29825860
TI  - Matrons in Council.

PMID- 29825861
TI  - What One Secretary Is Thinking.

PMID- 29825862
TI  - The Rotunda and Coombe Hospitals.

PMID- 29825864
TI  - Legal Notes for Institutional Workers.

PMID- 29825863
TI  - Raising a Ghost It Were Better to Lay.

PMID- 29825866
TI  - Round the Hospitals.

PMID- 29825865
TI  - The Hospital.

PMID- 29825868
TI  - The Lighting of Operating Theatres: by Day and by Night.

PMID- 29825867
TI  - A Hospital Day in Salonika.

PMID- 29825870
TI  - An Interpretation of Medicine to the Lay Public.

PMID- 29825869
TI  - King George's Fund for Sailors.

PMID- 29825872
TI  - Food in Wartime.

PMID- 29825871
TI  - The County Infirmaries and the College.

PMID- 29825873
TI  - Hospital and Institutional News.

PMID- 29825874
TI  - "He Was Bought a Bun".

PMID- 29825875
TI  - National Service under New Management.

PMID- 29825877
TI  - Medical Certificates for Insurance Purposes.

PMID- 29825876
TI  - The Royal British Nurses' Association.

PMID- 29825878
TI  - Hospital and Institutional News.

PMID- 29825879
TI  - "Raising a Ghost It Were Better to Lay".

PMID- 29825881
TI  - The Suffrage and Florence Nightingale.

PMID- 29825880
TI  - North Staffordshire Infirmary: The Way to Get Money.

PMID- 29825882
TI  - Why British Public Sanatoria Have Failed.

PMID- 29825883
TI  - The Military Position of the Medical Student in Great Britain and in America: A
      Contrast in Policy and Methods.

PMID- 29825884
TI  - A State Censorship Favoured.

PMID- 29825886
TI  - Round the Hospitals.

PMID- 29825885
TI  - Nursing Affairs in Ireland.

PMID- 29825888
TI  - The Hospital.

PMID- 29825887
TI  - "He Was Bought a Bun".

PMID- 29825889
TI  - Practical Food of Real Value: I. Why and Where Hospitals Cost More.

PMID- 29825890
TI  - "Raising a Ghost"-And Laying a Controversy.

PMID- 29825892
TI  - The Way to Kill Waiting-Lists, and How to Pay for Additional Upkeep.

PMID- 29825891
TI  - Nitrous Oxide and Oxygen.

PMID- 29825893
TI  - Advantages and Disadvantages.

PMID- 29825894
TI  - The College of Nursing, Limited.

PMID- 29825896
TI  - On Certainties and Probabilities.

PMID- 29825895
TI  - The Statistics of 109 Metropolitan Hospitals for 1916.

PMID- 29825898
TI  - Thinking in Calories.

PMID- 29825897
TI  - Hospital and Institutional News.

PMID- 29825900
TI  - Parliament and the Profession.

PMID- 29825899
TI  - The Hospital.

PMID- 29825901
TI  - Round the Hospitals.

PMID- 29825902
TI  - Sir Arthur Newsholme's Annual Report, 1916-17.

PMID- 29825903
TI  - Parliament and the Profession.

PMID- 29825904
TI  - A Study of Nursing Progress and Its Development.

PMID- 29825905
TI  - Payment for Military Patients and Treatment of Discharged Warriors.

PMID- 29825906
TI  - The Economic Use of the Medical Profession.

PMID- 29825907
TI  - Hospital and Institutional News.

PMID- 29825908
TI  - Hammock Suspension of Fractures.

PMID- 29825909
TI  - A War-Time Christmas in Hospitals.

PMID- 29825911
TI  - The Churches and Venereal Marriages: Do They Treat Marriage as a Sacrament or
      Not?

PMID- 29825910
TI  - Treatment of Severe Facial Injuries.

PMID- 29825912
TI  - Round the Hospitals.

PMID- 29825913
TI  - Midwifery in London.

PMID- 29825914
TI  - The Hospital.

PMID- 29825915
TI  - "As Age Creeps On": Possible Troubles and How to Treat Them.

PMID- 29825916
TI  - American and British Doctors and the G.M.C.

PMID- 29825917
TI  - Practical Food of Real Value: II. Why and Where Hospitals Cost More.

PMID- 29825919
TI  - "Raising a Ghost It Were Better to Lay".

PMID- 29825918
TI  - The College of Nursing, Limited.

PMID- 29825920
TI  - Miss Matheson's Address.

PMID- 29825921
TI  - Parliament and the Profession.

PMID- 29825923
TI  - The Hospital.

PMID- 29825922
TI  - Medicine in the Great War.

PMID- 29825924
TI  - Round the Hospitals.

PMID- 29825925
TI  - Two Types of Medical Leader: No. 2. The Humbug.

PMID- 29825926
TI  - A Vital Question for Voluntary Hospitals.

PMID- 29825927
TI  - A Ministry of Health and Its Operations.

PMID- 29825929
TI  - Hun Surgeon's Murder.

PMID- 29825928
TI  - Women's Hospital, Dundee.

PMID- 29825931
TI  - The Royal British Nurses' Association: The Story of Recent Happenings.

PMID- 29825930
TI  - The Nightingale School and St. Thomas's Hospital.

PMID- 29825932
TI  - Hospital and Institutional News.

PMID- 29825933
TI  - A New Year Message.

PMID- 29825935
TI  - The Hospital.

PMID- 29825934
TI  - Salerno and Medical Women.

PMID- 29825936
TI  - A Straight Talk on Hospital Finances.

PMID- 29825938
TI  - Hospital and Institutional News.

PMID- 29825937
TI  - The Modern Jew: A Sociological and Biological Study.

PMID- 29825939
TI  - Round the Hospitals.

PMID- 29825940
TI  - The Best of the Old Year.

PMID- 29825942
TI  - Bolo Buried and Forgotten Everywhere.

PMID- 29825941
TI  - A New Children's Hospital.

PMID- 29825943
TI  - Vindication of the Medical Staff.

PMID- 29825944
TI  - Nursing Progress and Its Developments: IV. Endowments for the College.

PMID- 29825945
TI  - That Is Sound Which Works.

PMID- 29825946
TI  - An Interlude and Two Reminiscences.

PMID- 29825947
TI  - Parliament and the Profession.

PMID- 29825948
TI  - The Prophylaxis of Venereal Diseases: An Offence against the General Interest.

PMID- 29825949
TI  - The Royal Statistical Society's National Value.

PMID- 29825950
TI  - Is Thy Secretary a Dog?

PMID- 29825951
TI  - Bringing down the Infantile Death-Rate: The Priestley Lecture of the National
      Health Society.

PMID- 29825952
TI  - A Pharmacist's Contribution to Hospital Economy.

PMID- 29825954
TI  - Hospital and Institutional News.

PMID- 29825953
TI  - The Hospital.

PMID- 29825956
TI  - The Amendment Bill Now before Parliament.

PMID- 29825955
TI  - A Home Sister of the Bygones.

PMID- 29825957
TI  - The College of Nursing and Its Opponents: A Remarkable Volte Face.

PMID- 29825959
TI  - Round the Hospitals.

PMID- 29825958
TI  - Westminster Hospital's Special Appeal.

PMID- 29825960
TI  - Prompt Action by Voluntary Hospitals Essential.

PMID- 29825961
TI  - The Story of the Red Cross.

PMID- 29825963
TI  - Sir Arthur Stanley's Letter: The Status of Nurses.

PMID- 29825962
TI  - Nursing Affairs in Ireland.

PMID- 29825964
TI  - A Complete System of Nursing: The Physician's View-What the Trained Nurse Thinks.

PMID- 29825966
TI  - Hospital and Institutional News.

PMID- 29825965
TI  - The London Hospital's Quinquennial Appeal: A Million Half-Crowns-Viscount
      Knutsford's Appeal.

PMID- 29825968
TI  - The Physical Fitness of the Nation.

PMID- 29825967
TI  - Some Unfounded Statements at Liverpool.

PMID- 29825969
TI  - The Hospital.

PMID- 29825970
TI  - List No. 4 of Training-Schools of Registered Nurses.

PMID- 29825971
TI  - The Unification of the Public Health Services.

PMID- 29825972
TI  - Institutional Needs.

PMID- 29825973
TI  - The Lords' Amendments to the New Bill.

PMID- 29825974
TI  - Round the Hospitals.

PMID- 29825975
TI  - Lord Lister: IV. Surgery in Pre-Listerian Days.

PMID- 29825976
TI  - The Medieval Attitude to Science.

PMID- 29825977
TI  - R.B.N.A. Speakers' Hostility to the College: Lay Governors and Hospital Chairmen
      Attacked.

PMID- 29825978
TI  - Having It out.

PMID- 29825980
TI  - Unrecognised Unilateral Blindness.

PMID- 29825979
TI  - Mr. Smallwood's Complaint.

PMID- 29825981
TI  - Hospital and Institutional News.

PMID- 29825982
TI  - The Hospital.

PMID- 29825984
TI  - Words and Things.

PMID- 29825983
TI  - The Midwives Bill.

PMID- 29825985
TI  - The Growth of the Nursing Profession: III. The Work of Reorganisation.

PMID- 29825986
TI  - Compensation and Aid for Air-Raid Victims.

PMID- 29825987
TI  - Parliament and the Profession.

PMID- 29825988
TI  - Lord Lister: III. Thirty Momentous Years.

PMID- 29825989
TI  - Round the Hospitals.

PMID- 29825991
TI  - Mission Hospitals and Publicity.

PMID- 29825992
TI  - Nerve-Shattered Pensioners: More "Country Hosts" Needed.

PMID- 29825990
TI  - The Voluntary Hospitals.

PMID- 29825993
TI  - War Office Increases Payments to Hospitals.

PMID- 29825994
TI  - The Great War: Wonderful Progress in Evacuation and Care of the Wounded.

PMID- 29825995
TI  - Promotion of Officers.

PMID- 29825996
TI  - Parliament and the Profession.

PMID- 29825997
TI  - The Royal Lancaster Infirmary (Temporary Wing).

PMID- 29825998
TI  - Round the Hospitals.

PMID- 29825999
TI  - The Belgian Doctors and Pharmacists.

PMID- 29826000
TI  - The Prevention of Scurvy: Some Recent Researches upon Vitamines.

PMID- 29826001
TI  - The Hospital.

PMID- 29826002
TI  - Hospital and Institutional News.

PMID- 29826003
TI  - Consumptive Combatants.

PMID- 29826004
TI  - How to Secure Efficient Surgery.

PMID- 29826006
TI  - The Growth of the Nursing Profession. II. Become Founders and Helpers of
      Democratic Government.

PMID- 29826005
TI  - "London" Nurses and Their Emoluments.

PMID- 29826007
TI  - New Powers for Urban and District Councils.

PMID- 29826008
TI  - The Year's Work and War Prices.

PMID- 29826009
TI  - The Organisation in North Lambeth.

PMID- 29826011
TI  - Lord Lister: His Work, His Teaching, and Benefits to Mankind.

PMID- 29826010
TI  - The Medico-Psychological Association.

PMID- 29826012
TI  - Nursing Progress and Its Developments: VI. The Probationer's First Two Years.

PMID- 29826013
TI  - Report of the Distribution Committee.

PMID- 29826014
TI  - The Medical Ward Sister: "A Sermon on the Mount."

PMID- 29826015
TI  - In a Territorial Hospital.

PMID- 29826017
TI  - An Idle Rumour Resting on Malice.

PMID- 29826016
TI  - Prison for Boys-and the Remedy.

PMID- 29826018
TI  - Personal Service Triumphant.

PMID- 29826019
TI  - Distribution of Medals in an Auxiliary Hospital.

PMID- 29826020
TI  - Report of the Convalescent Homes Committee.

PMID- 29826022
TI  - Grants Recommended by the Convalescent Homes Committee.

PMID- 29826021
TI  - The Training of Recruits for Nursing Orderlies.

PMID- 29826023
TI  - Parliament and the Profession.

PMID- 29826024
TI  - Hospital and Institutional News.

PMID- 29826025
TI  - Should the Doctor Tell?

PMID- 29826026
TI  - A Moment of Leisure.

PMID- 29826027
TI  - Round the Hospitals.

PMID- 29826028
TI  - Nursing Affairs in Ireland.

PMID- 29826029
TI  - Grants to Hospitals Recommended by the Distribution Committee.

PMID- 29826030
TI  - Nursing Progress and Its Developments: III. Nursing as a Science.

PMID- 29826031
TI  - Village Practice.-II: An Autobiographical Fragment.

PMID- 29826032
TI  - The Distribution Meeting.-L190,000 Awarded.

PMID- 29826033
TI  - Middlesex Hospital.

PMID- 29826034
TI  - The Orphan Working School.

PMID- 29826036
TI  - Round the Hospitals.

PMID- 29826035
TI  - University Developments.

PMID- 29826037
TI  - The Two Pathways: Which Will the World Choose?

PMID- 29826038
TI  - Mr. H. J. Paterson, F.R.C.S., with His Camera: Some Remarkable Views.

PMID- 29826039
TI  - More Enemy War-Cries: Lay Control.

PMID- 29826040
TI  - Hospital and Institutional News.

PMID- 29826041
TI  - The Hospital.

PMID- 29826042
TI  - Sir Alfred Keogh, G.C.B. M.D.: Rector of the Imperial College of Science and
      Technology.

PMID- 29826043
TI  - The Growth of the Nursing Profession: The Habit of Talking Too Much.

PMID- 29826044
TI  - The Home Sister of My Alma Mater.

PMID- 29826045
TI  - Some Masters of Mediaeval Surgery.

PMID- 29826046
TI  - The "Rewa" Outrage.

PMID- 29826048
TI  - Nursing Progress and Its Development: V. The Nurse-Pupil's First Stage.

PMID- 29826047
TI  - Institutional Needs.

PMID- 29826050
TI  - Hundreds of Nurses Join Its Register.

PMID- 29826049
TI  - The Shortage of Doctors.

PMID- 29826051
TI  - Bolo Buried and Forgotten Everywhere.

PMID- 29826052
TI  - The Order of the British Empire.

PMID- 29826053
TI  - The Hospital.

PMID- 29826054
TI  - Institutional Housekeeping under the Poor-Law.

PMID- 29826055
TI  - The Speaker and the Hospitals.

PMID- 29826056
TI  - Hospital and Institutional News.

PMID- 29826057
TI  - Physical Culture in Education: Greek, French, and German Systems.

PMID- 29826058
TI  - Round the Hospitals.

PMID- 29826059
TI  - The Medical Profession and a Ministry of Health.

PMID- 29826060
TI  - The Organisation of Gifts in Kind.

PMID- 29826061
TI  - What Every Trained Nurse Should Know.

PMID- 29826062
TI  - The Practice of Percussion: As Influenced by the Newer Methods.

PMID- 29826063
TI  - Parliament and the Profession.

PMID- 29826064
TI  - Hospital Needs and Hospital Appeals.

PMID- 29826065
TI  - The Hospital.

PMID- 29826066
TI  - Nursing Progress and Its Developments: II. The Probationer as Student.

PMID- 29826067
TI  - The Third London Artists and Their Work.

PMID- 29826069
TI  - Nursing Affairs in Ireland.

PMID- 29826068
TI  - The Medical Problems of Flying.

PMID- 29826071
TI  - When Wounded-And Afterward.

PMID- 29826070
TI  - Their Place in the War Industries To-Day.

PMID- 29826073
TI  - Our Food and Ourselves.

PMID- 29826072
TI  - Work at Gaza.

PMID- 29826074
TI  - Round the Hospitals.

PMID- 29826076
TI  - Some Penal Cases.

PMID- 29826075
TI  - Hospital and Institutional News.

PMID- 29826077
TI  - The Churches and Venereal Marriages.

PMID- 29826079
TI  - Lady Roberts' Field Glass Fund.

PMID- 29826078
TI  - A Medical Officer's Libel Action.

PMID- 29826080
TI  - The Fourth War Christmas: Its Celebration in Some Representative Institutions.

PMID- 29826081
TI  - Lord Lister: VI. Lister's Hypothesis of the Cause of Suppuration.

PMID- 29826083
TI  - Nursing Progress and Its Developments: VIII. Supporters of the College.

PMID- 29826082
TI  - The Hospital.

PMID- 29826085
TI  - Camouflage.

PMID- 29826084
TI  - Hospital and Institutional News.

PMID- 29826087
TI  - Of Medical Certificates.

PMID- 29826086
TI  - The General Practitioner and Consumption.

PMID- 29826088
TI  - Liverpool Centre Inaugurated.

PMID- 29826089
TI  - Madhouses before A.D. 1846.

PMID- 29826091
TI  - Church Missions Hospital, Jerusalem.

PMID- 29826090
TI  - Food Problem Notes.

PMID- 29826092
TI  - Man-Power and Men with Defective Physique.

PMID- 29826093
TI  - Round the Hospitals.

PMID- 29826094
TI  - Tact in Sanatorium Management.

PMID- 29826096
TI  - Round the Hospitals.

PMID- 29826095
TI  - Increase in War Office Capitation Grant.

PMID- 29826097
TI  - Temporary Hospital Staff Appointments.

PMID- 29826098
TI  - Increased Capitation Grants to Civil Hospitals.

PMID- 29826099
TI  - Lord Lister: V. His Early Researches and Conclusions.

PMID- 29826100
TI  - The Great War: II. With the Wounded at the Front.

PMID- 29826101
TI  - Lunacy in 1916.

PMID- 29826102
TI  - Parliament and the Profession.

PMID- 29826104
TI  - Some Medical Difficulties of Life Assurance.

PMID- 29826103
TI  - The Growth of the Nursing Profession: IV. Some Economic and Practical Aspects.

PMID- 29826106
TI  - The First Annual Report.

PMID- 29826105
TI  - Hospital and Institutional News.

PMID- 29826107
TI  - Words and Things.

PMID- 29826108
TI  - The Temptation of Economical Management.

PMID- 29826109
TI  - Leicester Saturday Hospital Society.

PMID- 29826111
TI  - The Importance of the Vegetable Course.

PMID- 29826110
TI  - Addenbrooke's Hospital, Cambridge: Quarterly Court.

PMID- 29826112
TI  - Public Pharmacists' Association.

PMID- 29826113
TI  - The Shortage of Husbands.

PMID- 29826114
TI  - The College of Nursing Election.

PMID- 29826115
TI  - East and West in the Medical School.

PMID- 29826116
TI  - The Growth of the Nursing Profession: V. Knowledge and Practice in Nursing.

PMID- 29826117
TI  - Education in Food Economy.

PMID- 29826118
TI  - His Majesty the Pig: His Paramount Importance in the Great War.

PMID- 29826119
TI  - A Short History by the Viscountess Cowdray.

PMID- 29826120
TI  - What Nurses Should Seek and Find.

PMID- 29826121
TI  - From a Sanatorium.

PMID- 29826123
TI  - Round the Hospitals.

PMID- 29826122
TI  - Alcohol and the Human Body.

PMID- 29826124
TI  - The Institution Garden: I. What to Do and How to Do It.

PMID- 29826125
TI  - Men, Women, and Bastards: Some Pressing Questions of Great Importance.

PMID- 29826126
TI  - Hospital and Institutional News.

PMID- 29826127
TI  - War Charities.

PMID- 29826128
TI  - List No. 5 of Training-Schools of Registered Nurses.

PMID- 29826129
TI  - Parliament and the Profession.

PMID- 29826130
TI  - Games for the Men.

PMID- 29826132
TI  - Medical Treatment in the Home.

PMID- 29826131
TI  - Lord Lister: VIII: Through Pus to Surgical Cleanliness.

PMID- 29826134
TI  - Parliament and the Profession.

PMID- 29826133
TI  - The Hospital.

PMID- 29826135
TI  - Lord Lister: X. His Search for Three Ideals.

PMID- 29826136
TI  - Hospital and Institutional News.

PMID- 29826137
TI  - Meeting at Plymouth.

PMID- 29826138
TI  - Meeting of the Liverpool Centre.

PMID- 29826139
TI  - The Mental Deficiency Act at Work: A Surprising War-Time Achievement.

PMID- 29826140
TI  - Nursing Progress and Its Developments: XI. The Grandeur of the Nation's Nursing
      Services.

PMID- 29826142
TI  - Propaganda: The Effort Towards Union.

PMID- 29826141
TI  - Mr. G. Q. Roberts on St. Thomas's Hospitals History: A Few of His Interesting
      Photographs.

PMID- 29826143
TI  - The Territorial Medical Officers.

PMID- 29826144
TI  - Psychological Tests or Rubbish?

PMID- 29826145
TI  - The Problem of the Town-Bred Child.

PMID- 29826146
TI  - Bone-Grafting in Relation to Sepsis.

PMID- 29826148
TI  - A Study of the "End Result" System.

PMID- 29826147
TI  - Round the Hospitals.

PMID- 29826150
TI  - Mr. D'Arcy Power's Evokement of "Bart.'s."

PMID- 29826149
TI  - Reports of Scottish Asylums.

PMID- 29826151
TI  - Lord Lister: IX. The Drainage Tube, and Ligatures.

PMID- 29826152
TI  - Parliament and the Profession.

PMID- 29826153
TI  - Nursing Progress and Its Developments: X. Local Centres for Examinations.

PMID- 29826154
TI  - The Hospital.

PMID- 29826156
TI  - Organisation: Voluntary, or Compelled?

PMID- 29826155
TI  - Toward Union.

PMID- 29826157
TI  - The Great War: IV. Sickness.

PMID- 29826158
TI  - The Navy and Our Sailors: A Memorable Annual Meeting.

PMID- 29826160
TI  - Round the Hospitals.

PMID- 29826159
TI  - Hospital and Institutional News.

PMID- 29826162
TI  - The Institution Garden: II. What to Do and How to Do It.

PMID- 29826161
TI  - The Material Value of AEsthetics.

PMID- 29826163
TI  - Payment of the Medical Staff.

PMID- 29826164
TI  - Hospital and Institutional News.

PMID- 29826165
TI  - Food Problem Notes.

PMID- 29826166
TI  - Parliament and the Profession.

PMID- 29826167
TI  - Lord Lister: VII. Antisepis and Asepsis.

PMID- 29826168
TI  - Dangers from Ligature of Main Arteries.

PMID- 29826169
TI  - Prince of Wales' Hospital, Cardiff: Opening by the Prince in Person.

PMID- 29826170
TI  - The Great War: III. The Expeditionary Force Base.

PMID- 29826171
TI  - The Hospital.

PMID- 29826172
TI  - The Enemy of the Race.

PMID- 29826173
TI  - Round the Hospitals.

PMID- 29826174
TI  - The Informed Verdict.

PMID- 29826175
TI  - Nursing Progress and Its Developments: IX. The Local Centres of the College of
      Nursing.

PMID- 29826176
TI  - Work of the past Quarter.

PMID- 29826178
TI  - Meeting at the Dreadnought Hospital.

PMID- 29826177
TI  - Democratic Ideals.

PMID- 29826179
TI  - Miss Agnes Jones' Great Work.

PMID- 29826181
TI  - Points from the Quarterly Report.

PMID- 29826180
TI  - The After-Care of the Disabled Soldier.

PMID- 29826183
TI  - Hospitals and the Spirit Tax.

PMID- 29826182
TI  - Awards for Valuable Services in Connection with the War.

PMID- 29826184
TI  - Mother of "a Living or Viable Child," Aged Forty-Eight, or over?

PMID- 29826185
TI  - Round the Hospitals.

PMID- 29826186
TI  - The Criminal Law Amendment Bill.

PMID- 29826187
TI  - The White City Case.

PMID- 29826188
TI  - The Care of the Disabled Soldier.

PMID- 29826189
TI  - Certificated Trained Nurses and the Poor Law.

PMID- 29826190
TI  - The Patients' Meat Ration.

PMID- 29826191
TI  - Hospital and Institutional News.

PMID- 29826192
TI  - Red Cross Accountancy: The Policy of the Big Balance.

PMID- 29826193
TI  - Parliament and the Profession.

PMID- 29826194
TI  - Suggested Irish Board to Grant Diplomas to Nurses.

PMID- 29826196
TI  - Doctors in Fiction.

PMID- 29826195
TI  - Cerebro-Spinal Fever in the Newer Light: The Community Versus the Microbe.

PMID- 29826197
TI  - Flower Services and Hospitals.

PMID- 29826198
TI  - The National Pension Fund.

PMID- 29826199
TI  - A Friendly Alias: Chapters I and II.

PMID- 29826200
TI  - Nerves: Their Uses and Troubles.

PMID- 29826201
TI  - Philanthropy as a Career.

PMID- 29826202
TI  - The Work of the Holy Ghost.

PMID- 29826203
TI  - The Story of the Hospitals: Guy's Hospital.

PMID- 29826204
TI  - The Medical Treatment of Women in India.

PMID- 29826205
TI  - Annotations: The Hospitals Association and Its Future Work.-Cook Your Milk.-Who
      Nurses the Sick Nurse? -Bald Heads.

PMID- 29826206
TI  - Notes and News: Miscellaneous Hospital Items.- Opening of the National Hospital,
      Bloomsbury, by the Duchess of Albany.-Bazaars, Festivals, etc., in Aid of the
      Hospitals.-Vacancies.-Medical Relief and the Charity Organisation Society.-The
      Miners' Hospital. -Convalescent Home or Hospital.-The Mary Wardell Convalescent
      Home.-Prize Day at St. Thomas's Medical School.-The Nottingham General Hospital.
      New Hospital at Bournemouth.-The Bath Mineral Water Hospital.- Hospital Saturday
      Fund Returns.- The Rugby Provident Dispensary.- Artificial Respiration for the
      Drowned.-The Worcester Infirmary and the Monthly Visitors.-Annual Meetings and
      Reports, etc.

PMID- 29826207
TI  - Reminiscences of the Insane.

PMID- 29826208
TI  - Some Dangers of Spring.

PMID- 29826209
TI  - Nurse Marion's Romance: Chapter VII. The Acme of Selfishness.

PMID- 29826210
TI  - Annotations: The Hospital Porter.-Glasgow Charities and Doctors.

PMID- 29826211
TI  - The Work of the Holy Ghost.

PMID- 29826212
TI  - Insanity in Child-Bearing: Part I. Puerperal Forms.

PMID- 29826213
TI  - Chats about Medical Museums: IV. University College.

PMID- 29826214
TI  - A National Pension Fund for Hospital Officials and Nurses: The Views of
      Officials, Sisters, Nurses, and Others.

PMID- 29826215
TI  - Fever Nurses: Their Dangers and Defences.

PMID- 29826216
TI  - Shall We Give up the Novel?

PMID- 29826217
TI  - Natural and Artificial Ventilation of Hospitals.

PMID- 29826218
TI  - Curiosities of Ancient Leechcraft.

PMID- 29826219
TI  - Notes and News: The Prince and Princess of Wales and the London Hospital.-Gifts
      to Hospitals.-The Islington Dispensary.-" First Aid."-Hospital Appeals. 
      Vacancies.-The British Ophthalmic Hospital, etc.

PMID- 29826220
TI  - A National Pension Fund for Hospital Officials and Nurses: The Views of
      Officials, Sisters, Nurses, and Others.

PMID- 29826221
TI  - Notes and News: Miscellaneous Items.-The Jaffa Medical Mission Hospital.-The
      National Pension Fund, etc., etc.

PMID- 29826222
TI  - Curiosities of Ancient Leechcraft.

PMID- 29826223
TI  - Saints on Earth.

PMID- 29826225
TI  - Disinfection in and after Fever Cases.

PMID- 29826224
TI  - Insanity in Child-Bearing: Other Forms of Mental Disorders.

PMID- 29826226
TI  - The Work of the Holy Ghost.

PMID- 29826227
TI  - Incidents of Animal Life: Dogs and Their Doings.

PMID- 29826228
TI  - The Poor in Towns.

PMID- 29826229
TI  - Hospital Worthies.

PMID- 29826230
TI  - Annotations: Hospital Book-Keeping.-Hospital Sunday.-Dynamite as a Life
      Preserver.

PMID- 29826231
TI  - The Children's Ward.

PMID- 29826232
TI  - Nursing Institutions in the Country.

PMID- 29826233
TI  - Novel or No Novel.

PMID- 29826235
TI  - Death.

PMID- 29826234
TI  - The Ventilation of Hospitals.

PMID- 29826236
TI  - Nurse Marion's Romance: Chapter VI. The Widow Explains.

PMID- 29826237
TI  - The Artificial and Natural Ventilation of Hospitals.

PMID- 29826238
TI  - A National Pension Fund for Hospital Officials and Nurses: The Views of
      Officials, Sisters, Nurses, and Others.

PMID- 29826239
TI  - A Noble Dog.

PMID- 29826240
TI  - Annotations: Ambulance and Self-Help at Leeds.-Still Unreformed.-Grumblers.

PMID- 29826241
TI  - Death against Doctors.

PMID- 29826242
TI  - Infection and Disinfection.

PMID- 29826243
TI  - The Hospital Saturday Fund.

PMID- 29826245
TI  - "The Hospital's" Nursery Rhymes.

PMID- 29826244
TI  - The Medical Student's Complaint.

PMID- 29826246
TI  - Notes and News: Hospital Appointments.-The Liverpool Foundling Hospital.
      Miscellaneous Hospital Intelligence.-Vacancies.-Morley House Seaside Home.
      Entertainments in Aid Guy's Hospital.-Donations, Legacies, etc., to Medical
      Charities.-The Pembrokeshire and Haverfordwest Infirmary, etc.

PMID- 29826248
TI  - Anaesthetics: A Stimulus to Voluntary Effort.

PMID- 29826247
TI  - One Year Probationers.

PMID- 29826249
TI  - Miss Manson's Paper: Two Protests.

PMID- 29826250
TI  - The National Pension Fund.

PMID- 29826251
TI  - The Ventilation of Hospitals.

PMID- 29826252
TI  - The Time of Lenten Lilies.

PMID- 29826253
TI  - Nurse Marion's Romance: Chapter V. Complications.

PMID- 29826255
TI  - Notes and News: Appointments.-Miscellaneous Items.-The French Protestant
      Hospital.-Newton Cottage Hospital Report.-Vacancies.-Curious Advertising.-The
      Late Duchess of Norfolk.-Donations, Legacies, Etc., to Medical Charities, Etc.,
      Etc.

PMID- 29826254
TI  - Moral and Physical Massage.

PMID- 29826257
TI  - Kilts and Physic.

PMID- 29826256
TI  - Half a Million of Money in Sight.

PMID- 29826258
TI  - Woodhall Spa.

PMID- 29826259
TI  - Death.

PMID- 29826260
TI  - Annotations: The King of the Belgians at the London Hospital.-Admission and
      Discharge of Patients.-Religion in French Hospitals.

PMID- 29826261
TI  - The Song of the Iron Pill.

PMID- 29826263
TI  - Hospital Saturday.

PMID- 29826262
TI  - A National Pension Fund for Hospital Officials and Nurses: The Views of
      Officials, Sisters, Nurses, and Others.

PMID- 29826265
TI  - Drugs or No Drugs?

PMID- 29826264
TI  - Chats about Medical Museums: No. VII. King's College.

PMID- 29826266
TI  - Counterparts: Chap. I.

PMID- 29826267
TI  - Words for the Wise.

PMID- 29826268
TI  - Annotations: Co-Operation among the Working Classes.-A New Cure for Consumption.

PMID- 29826269
TI  - A Crusade against Indifference: Meetings in Aid of the Hospital Sunday Fund.

PMID- 29826270
TI  - Notes and News: Miscellaneous Hospital News.- Jubilee Celebrations.-The Hospital
      Campaign.- Hospital Extension in the Isle of Man.-Concert at Grosvenor House.
      Hospital Subjects at Burlington House.- Vacancies. -The Royal Family at the
      Tottenham Hospital.-"Instantaneous" Remedies.- The Seamen's Hospital.- The Poplar
      Hospital.- Donitiois, Legacies, etc., to Medical Charities.-Proposed Convalescent
      Home for Barmouth.- Hospital Reports.- New England Hospital for Women and
      Children.-Ladv Doctors, etc., etc.

PMID- 29826271
TI  - Treatment of Emergencies.

PMID- 29826272
TI  - The Archbishop of Canterbury on Hospitals.

PMID- 29826273
TI  - The Work of the Holy Ghost.

PMID- 29826274
TI  - Let There Be Light.

PMID- 29826276
TI  - Objects and List of Meetings.

PMID- 29826275
TI  - Life in Hospital: Mrs. Johnson Argues the Point.-A Good Investment.- Can't It Be
      Done at Home?-The Pavilion Plan.- A Model Ward.-Sister Grace.-No Respect of
      Persons. -A Melancholy Night.-The Tight-Rope Dancer.- Early Morning in the Ward.
      The House Surgeon.- To Pay for Your Keep.-Amateur Chaplains: Sunday Afternoon.-No
      Cakes Allowed.-The Operation.- Spray v. Germs: A Lilliputian Battle.-"He Prayeth
      Best Who Loveth Best."-The Convalescent Home.- School in the Ward, etc., etc.

PMID- 29826277
TI  - The Origin of Hospitals.

PMID- 29826279
TI  - Hospital Sunday and the Queen's Jubilee.

PMID- 29826278
TI  - The Sick and the Hospitals.

PMID- 29826281
TI  - The National Pension Fund.

PMID- 29826280
TI  - Notices to the Clergy and Ministers of Religion.

PMID- 29826283
TI  - Mr. Spurgeon on Hospitals.

PMID- 29826282
TI  - Buttercups and Daisies.

PMID- 29826284
TI  - Annotations: Hospitals "Sitting on the Fence."- A Happy Thought.-Provident
      Dispensaries.

PMID- 29826285
TI  - Incidents of the Hospital Meetings.

PMID- 29826286
TI  - Notes and News: Hospital Appointments.-Hospital Saturday Bazaar at Lincoln.
      Hospital Collecting-Boxes in Wimbledon Camp.-The Ormsby Cottage Hospital. -The
      Supply of Goods to Hospitals.-The Paddington Children's Hospital.-Vacancies.-The
      Poplar Accident Hospital.-The Wigan Infirmary.-The City Orthopaedic Hospital.
      Hospital Collections at Worthing. -Proposed New Hospitals.-The Royal South Hants
      Infirmary.-Bazaars and Entertainments in Aid of Hospitals.-Annual Report of the
      Birmingham and Midland Skin Hospital.-The Edinburgh Association for Incurables.
      The Sunderland Infirmary.-The Glasgow Hospitals, etc., etc.

PMID- 29826287
TI  - After the Battle.

PMID- 29826288
TI  - The Work of the Holy Ghost.

PMID- 29826289
TI  - Hospital Sunday at the Synagogue.

PMID- 29826290
TI  - Rheumatism.

PMID- 29826292
TI  - Hospital Sunday.

PMID- 29826291
TI  - Counterparts: Chap. III.

PMID- 29826294
TI  - The Work of the Holy Ghost.

PMID- 29826293
TI  - Facts about Hospitals: For Preachers, etc.

PMID- 29826295
TI  - Trained Nurses' Fund.

PMID- 29826296
TI  - Notes and News: Prince Albert Victor and the Donnybrook Hospital.-Entertainments
      in Aid of the Hospitals.-Hospital Enlargement.-Vacancies, etc., etc.

PMID- 29826297
TI  - The Metropolitan Hospital Sunday Fund.

PMID- 29826298
TI  - Annotations: Who Cares for the Pauper Children?- A New Lunatic Asylum for
      Middlesex.-Good Women.

PMID- 29826299
TI  - Heroism.

PMID- 29826301
TI  - A Preaching Match: The Sunday Fund.

PMID- 29826300
TI  - Counterparts: Chap. II.

PMID- 29826302
TI  - A Crusade against Indifference.

PMID- 29826303
TI  - Are There More Lunatics Than Formerly?

PMID- 29826304
TI  - Notes and News: Hospital Appointments.-Working Men and the Hospitals.-Vacancies.
      Photographs and Albums for Hospitals.-The Princess Alice Hospital Jubilee Fete.
      State-Supported Hospitals.- Church Parade in Aid of the Children's Hospital. 
      Hospital Collection-Boxes in Theatres.-Distribution of the Sunday Fund Number of
      The Hospital.-The Dundee Royal Infirmary, etc.

PMID- 29826306
TI  - The National Pension Fund.

PMID- 29826305
TI  - The Out-Patient Department.

PMID- 29826307
TI  - Patients: From the Doctor's Point of View.

PMID- 29826308
TI  - Treatment of Emergencies.

PMID- 29826309
TI  - Flowers for the London Poor.

PMID- 29826310
TI  - Annotations: Careless Dispensing.-The Growth of the Sunday Fund.-Doctors "Out in
      the Cold".

PMID- 29826312
TI  - Two Guineas, Madam.

PMID- 29826311
TI  - Unlicensed Practitioners.

PMID- 29826314
TI  - The Work of the Holy Ghost.

PMID- 29826313
TI  - Counterparts: Chap. IV. A Discovery.

PMID- 29826316
TI  - The Story of the Hospitals: The London Hospital.

PMID- 29826315
TI  - The Nurse and the Sick-Room.

PMID- 29826317
TI  - Glass Eyes: Their Manufacture and Cost.

PMID- 29826318
TI  - The Work of the Holy Ghost.

PMID- 29826319
TI  - Hospital Charity: The Best Means of Preventing Its Abuse.

PMID- 29826321
TI  - A National Pension Fund for Hospital Officials and Nurses: The Views of
      Officials, Sisters, Nurses, and Others.

PMID- 29826320
TI  - Notes and News: The Queen and the French Hospital.-Miscellaneous Items.
      Vacancies.-Bazaar in Aid of King's College Hospital.-The Bristol Royal Infirmary.
      Hospital Building Tenders.-Subscription Ball at Prince's Hall.-Friendly and Trade
      Societies' Demonstrations.-Donations and Legacies to Medical Charities.-Police
      Sergeant Barker.-Hospital Entertainments, etc.

PMID- 29826322
TI  - Annotations: The Vienna Hospital Scandal.-A Book of Grievances.-The Registration
      of Trained Nurses.

PMID- 29826323
TI  - A Lady Doctor on Health and Disease.

PMID- 29826324
TI  - And Who Is My Neighbour?

PMID- 29826325
TI  - Chats about Medical Museums: No. 5. Guy's Hospital.

PMID- 29826326
TI  - Moral and Physical Massage: I. Explanatory and Descriptive.

PMID- 29826328
TI  - Public and Private Nursing Institutions.

PMID- 29826327
TI  - Notes and News: Miscellaneous Items.-Hospital Enlargement.-Lecture in Aid of the
      Royal Hospital for Children.-New Hospital for Glasgow.-Annual Report of the
      Shrophire and Wales Eye Hospital-Vacancies.-"Give Your Gold to the Hospitals."
      The North-West London Hospital.-The Wolverhampton and Staffordshire General
      Hospital.-The Bristol Royal Infirmary.-Donations, Legacies, etc., to Medical
      Charities.-The Midwives' Institute and Trained Nurses' Club.-Convalescent Home
      for Working Men.-The Children's Hospital at Chelsea.-Lunacy in Russia, etc.

PMID- 29826330
TI  - Sydney Smith as a Doctor.

PMID- 29826329
TI  - Nurse Marion's Romance: Chapter III. Jack Holtayne in Hospital.

PMID- 29826331
TI  - Chats about Medical Museums: No. III.

PMID- 29826332
TI  - Small Economies in Cottage Hospital Management.

PMID- 29826333
TI  - Annotations: The National Pension Fund.-Private Wards for Lying-In Cases.
      Hospital Locum Tenens.

PMID- 29826335
TI  - Sleep and Sleeplessness.

PMID- 29826334
TI  - The Advertisements of Endowed Hospitals.

PMID- 29826337
TI  - Early Rising: Cheerful Health.

PMID- 29826336
TI  - Death.

PMID- 29826338
TI  - Nurse Marion's Romance: Chapter IV. The Crisis.

PMID- 29826339
TI  - The Harley Street Establishment for Invalid Gentlewomen.

PMID- 29826340
TI  - Easter Eggs.

PMID- 29826341
TI  - Annotations: Free Criticism.-The Aberdeen Royal Infirmary.-Amusements in
      Hospitals.

PMID- 29826343
TI  - Every-Day Ailments.

PMID- 29826342
TI  - A National Pension Fund for Hospital Officials and Nurses: The Views of
      Officials, Sisters, Nurses, and Others.

PMID- 29826344
TI  - Death.

PMID- 29826345
TI  - Notes and News: Miscellaneous Items.- Jubilee "Banner Service."-Entertainment at
      the Cancer Hos- pital.-The St. John's Ambulance Association.-Hospital Saturday
      Fund and the London Cabmen.-Origin of Hospital Sunday.-Hospital Reports.
      Donations, etc., to Medical Charities.-Concert in Aid of the Miller Hos- pital.
      Lectures.-The Silloth Convalescent Institution. -Hospital Construction, etc.,
      etc.

PMID- 29826346
TI  - Bury Me in the Churchyard at Home.

PMID- 29826347
TI  - A Word to Hospital Patients.

PMID- 29826348
TI  - Trusses and Stockings.

PMID- 29826349
TI  - Moral and Physical Massage.

PMID- 29826350
TI  - Stories about Dogs.

PMID- 29826352
TI  - More Light.

PMID- 29826351
TI  - The Work of the Holy Ghost.

PMID- 29826353
TI  - Treatment of Emergencies.

PMID- 29826354
TI  - A Good Prescription.

PMID- 29826356
TI  - The Story of the Hospitals: Guy's Hospital.

PMID- 29826355
TI  - Wasted Holidays.

PMID- 29826357
TI  - Children's Diarrhoea.

PMID- 29826358
TI  - The National Pension Fund.

PMID- 29826359
TI  - Disinfectants.

PMID- 29826360
TI  - Dangerous Drugs: Bromide of Potassium.

PMID- 29826361
TI  - Annotations: Dishonourable Consultants.-Untrained Bathers.-"Sir Oracle."-Lemon
      Juice.

PMID- 29826362
TI  - Doctors in Fiction.

PMID- 29826363
TI  - Notes and News: Hospital Appointments.- The After-Care Association.- The
      Hospitals Association Meetings.- A Thank-Offering. Vacancies.- New Hospitals.--
      The Working Men and *he Hospitals.- Annual Meetings and Reports.-The London
      School of Medicine for Women.-The Devonshire Hcspital.- Scarlet Fever and School
      Fees.-Church Parade.- Grimsby Hospital and the Licensed Victuallers' Association.
      The Working People's Hospital Fund.- Fete at the Dublin Royal Hospital for
      Incurables.- Fancy Bazaar in Aid of Northallerton Cottage Hospital.

PMID- 29826364
TI  - A Friendly Alias: Chapter III.-Altered Lives.

PMID- 29826365
TI  - Hospital Worthies: John Radcliffe, M.D.

PMID- 29826366
TI  - The National Pension Fund.

PMID- 29826367
TI  - A Friendly Alias: Chapter IV and V.

PMID- 29826368
TI  - Alarming Result of Tight-Lacing.

PMID- 29826369
TI  - "Sponsors" for Out-Patients.

PMID- 29826370
TI  - Lanoline.

PMID- 29826371
TI  - Notes and News: Hospital Appointments.- The Croydon Children's Convalescent Home.
      The West Bromwich Self-Supporting Dispensary.-Charity Cup Competitions.-
      Hospital Meetings and Reports.- Vacancies.- The Cork Dispensary.- The United
      Friendly Societies and Medical Charities.-The Jenny Lind Infirmary.-Concerts and
      Bazaars in Aid of the Hospitals.-Metropolitan Police Convalescent Seaside Home.
      New Infirmary for Rutherglen.-The Bristol Royal Infirmary, etc., etc.

PMID- 29826372
TI  - Working Women: Their Present and Their Future.

PMID- 29826374
TI  - Annotations: Tweedledum or Tweedledee?-Wonderful Cure: Physic, Faith, or Neither?
      Women and Work.

PMID- 29826373
TI  - Llanfairfechan Convalescent Home.

PMID- 29826376
TI  - Hay-Fever.

PMID- 29826375
TI  - The Work of the Holy Ghost.

PMID- 29826377
TI  - Doctors in Fiction.

PMID- 29826378
TI  - Every-Day Ailments.

PMID- 29826379
TI  - The Brabazon Home of Comfort.

PMID- 29826380
TI  - Annotations: Endowed Beds.-Aberdeen and Its Hospitals.-Chronic Hospitals.

PMID- 29826381
TI  - A National Pension Fund for Hospital Officials and Nurses: By the Secretary of
      St. Mary's Hospital, the Matron of Oldham Infirmary, etc.

PMID- 29826383
TI  - An Italian Quack Doctor at Home.

PMID- 29826382
TI  - The Children's Jubilee Hymn.

PMID- 29826384
TI  - Public and Private Nursing Institutions.

PMID- 29826385
TI  - Notes and News: Items.-The Prince of Wales and the Victoria Hospital for
      Children.-Tooth Powders.-The East London Nursing Society.-Jubilee Dinners.
      Amputating under Difficulties, etc., etc.

PMID- 29826386
TI  - Reminiscences of the Insane.

PMID- 29826387
TI  - A Little Holiday in the Spring.

PMID- 29826388
TI  - Death.

PMID- 29826389
TI  - Nurse Marion's Romance: Chapter II. Marion's Home.

PMID- 29826390
TI  - Flowers, Ferns, and Ward Decorations.

PMID- 29826391
TI  - Nerves: Their Uses and Troubles.

PMID- 29826392
TI  - Annotations: Wooden Hospitals.-Convalescent Aid. -A Krupp Gun Wanted.

PMID- 29826393
TI  - Notes and News: Miscellaneous Hospital Intelligence.- Va ancies.- The Duke of
      Cambridge and the Chelsea Royal Hospital.-Prize Distribution at Charing Cross
      Hospital.-Hospital Resources.-Hospital Saturday Fund State Procession and
      Demonstration.-The Prince of Wales and the Sunderland Infirmary.-" The Repeated
      Jubilee Service" at Westminster Abbey.-The North-Eastern Hospital for Children. 
      Provident Dispensaries and the Hospitals, etc., etc.

PMID- 29826394
TI  - The Pension Fund for Nurses.

PMID- 29826395
TI  - More Knowledge and Thought Wanted.

PMID- 29826396
TI  - Begging Parsons.

PMID- 29826397
TI  - The Work of the Holy Ghost.

PMID- 29826398
TI  - Doctors in Fiction.

PMID- 29826399
TI  - Erratum: Norfolk and Norwich Hospital: A Correction.
AB  - [This corrects the article on p. 232 in vol. 2.].

PMID- 29826400
TI  - Children's Descriptions of Jubilee Celebrations.

PMID- 29826401
TI  - The Nurse and the Sick-Room.

PMID- 29826402
TI  - Old London Houses.

PMID- 29826403
TI  - The Chadwick Home Hospital, Liverpool.

PMID- 29826405
TI  - The National Pension Fund.

PMID- 29826404
TI  - Counterparts: Chapter V. How It All Ended.

PMID- 29826406
TI  - Annotations: Medical Men and Infectious Diseases. -Infectious Hospitals.-To Avoid
      Infection.

PMID- 29826407
TI  - A Children's Sermon. - Fairy Rings and Ringworms.

PMID- 29826408
TI  - Hospitals for Children.

PMID- 29826409
TI  - Notes and News: Miscellaneous Jottings.- The Royal Isle of Wight Infirmary.- The
      Beau Site Convalescent Home.- Bazaars.- Vacancies.- Church Parades.- The New
      Hospital at Blackpool.- The Medical Naval Service.-The Swindon Dissension.- The
      Tbaria Topun Hospital.- A Garden Party.- Hospital Reports. - Friendly and Trade
      Societies' Demonstrations.-Trained Nurses and the Royal Berks Hospital, etc.,
      etc.

PMID- 29826410
TI  - Chats about Medical Museums: VIII. The London Hospital.

PMID- 29826412
TI  - Treatment of Emergencies.

PMID- 29826411
TI  - The Condition of Midwives.

PMID- 29826413
TI  - The National Pension Fund.

PMID- 29826414
TI  - Fever Hospitals in Large Towns.

PMID- 29826415
TI  - A Hospital Scandal.

PMID- 29826416
TI  - The Sufferings of Christ.

PMID- 29826418
TI  - Ethel's Experiment.

PMID- 29826417
TI  - A Dog as an Out-Patient.

PMID- 29826419
TI  - A Parrot Story.

PMID- 29826420
TI  - Joseph Warren, M.D.

PMID- 29826421
TI  - Public and Private Nursing Institutions.

PMID- 29826423
TI  - Words for the Wise.

PMID- 29826422
TI  - The Story of the Hospitals: The London Hospitals.

PMID- 29826424
TI  - Annotations: The Hospitals Association.-The Hospitals Weeks.-Do Nothings.

PMID- 29826425
TI  - Notes and News: Hospital Items.-The Aberdeen Royal Infirmary.-Vacancies.-The
      Irving Dramatic Club.-Donations to Medical Charities, Etc.

PMID- 29826426
TI  - Chats about Medical Museums: No. VI. St. Bartholomew's Hospital.

PMID- 29826428
TI  - Novel or No Novel?

PMID- 29826427
TI  - A National Pension Fund for Hospital Officials and Nurses: The Views of
      Officials, Sisters, Nurses, and Others.

PMID- 29826430
TI  - Grateful Patients.

PMID- 29826429
TI  - Somebody's Darling.

PMID- 29826432
TI  - Fooling with a Panther.

PMID- 29826431
TI  - The Out-Patient Department.

PMID- 29826433
TI  - Hospital Worthies: Messenger Monsey, M.D., F.R.S.

PMID- 29826434
TI  - The Work of the Holy Ghost.

PMID- 29826436
TI  - Notes and News: Miscellaneous Items.-House-to-House Hospital Collections.-Open
      Air Concert in Aid of the Batley Cottage Hospital.-The Glasgow Medical Charities
      Committee.-Vacancies.-Game for Hospitals. -The Stratford-upon-Avon Infirmary.
      Cheap Trips.- Annual Sermons.-Hospital Exhibition.-Workshop Collections.
      Collecting Dogs.-The Scarlet Fever Epidemic.- The London Temperance Hospital.
      Donations in Aid of the Building Fund of the Great Northern Central Hospital.-Mr.
      F. R. Russell on Scarlet Fever.

PMID- 29826435
TI  - Treatment of Emergencies.

PMID- 29826437
TI  - A Holiday Sermon.

PMID- 29826438
TI  - Sober Science.

PMID- 29826439
TI  - Palmistry Notes.

PMID- 29826441
TI  - The National Pension Fund.

PMID- 29826440
TI  - Annotations: More Pasteur Failures.-Doctors and Druggists.-Anti-Vaccinators.

PMID- 29826443
TI  - Books for Hospitals.

PMID- 29826442
TI  - The Rod of Health.

PMID- 29826444
TI  - Kate Mountstephen: Chap. III. A Hard Question.

PMID- 29826445
TI  - A "Matron's Corner".

PMID- 29826447
TI  - Immediate Treatment in Cases of the More Common Poisons.

PMID- 29826446
TI  - The Sufferings of Christ.

PMID- 29826448
TI  - Unmarried Women.

PMID- 29826449
TI  - The Sufferings of Christ.

PMID- 29826451
TI  - Annotations: Costly Patient. - Where Is the Colchester Physician?-Doctors in
      Council.-Unparalleled Scepticism.

PMID- 29826450
TI  - The National Pension Fund.

PMID- 29826452
TI  - Invalid Children.

PMID- 29826453
TI  - Cruel Treatment of a Female Patient by Her Parents.

PMID- 29826454
TI  - Notes and News: Competitive Designs for Hospitals. - Hospital Annual Reports.-The
      Bute Hospital.-Guy's Hospital and the Special Appeal Fund.-Vacancies. -Beach Rock
      Convalescent Home. - The Lowestoft Convalescent Home. - Demonstration in Aid of
      the Huddersfield Infirmary.-The Liverpool Royal Infirmary and Its Officials.
      Proposed New Special Hospital for Nottingham, etc., etc.

PMID- 29826456
TI  - Religio Medici.

PMID- 29826455
TI  - Floating Hospital on the River Tyne.

PMID- 29826457
TI  - Hypochondriasis.

PMID- 29826458
TI  - What Live I for?

PMID- 29826460
TI  - The Stethoscope Song: A Professional Ballad.

PMID- 29826459
TI  - Guild of Friends of the Infirm in Mind.

PMID- 29826461
TI  - Religio Medici.

PMID- 29826462
TI  - The National Pension Fund.

PMID- 29826463
TI  - Chats about Medical Museums: IX.-The Middlesex Hospital.

PMID- 29826464
TI  - Notes and News: Miscellaneous Items. - Private Nursing Engagements.-Flower-Shows,
      Bazaars, etc., in Aid of Hospitals.-Special Hospitals.-The Hartlepools Hospital.
      Vacancies.-The Casualties at Whiteley's.-The Hospitals Association Meetings.
      Nurses and Their Work.-The Great Northern Central Hospital.-Annual Meetings and
      Reports.-The Norfolk and Norwich Hospital.-The Falkirk Association of Trained
      Nurses.-The Sandygate Sanatorium, etc.

PMID- 29826465
TI  - A Heroic Fireman.

PMID- 29826467
TI  - "Well-Guessed" or "Well-Done"?

PMID- 29826466
TI  - The Condition of Midwives.

PMID- 29826468
TI  - The Story of the Hospitals: The Royal National Hospital for Consumption, Ventnor.

PMID- 29826469
TI  - The Origin of Hospitals.

PMID- 29826471
TI  - Annotations: A Deluge of Doctors.-Men Must Do Something.-Why Don't Doctors
      Emigrate?-A Short Way with Medical Aspirants.

PMID- 29826470
TI  - Palmistry Notes.

PMID- 29826472
TI  - The Sufferings of Christ.

PMID- 29826473
TI  - An Army of Women.

PMID- 29826474
TI  - Blood-Letting.

PMID- 29826476
TI  - Kate Mountstephen: Chapter I.-The Test of Time.

PMID- 29826475
TI  - About Birds.

PMID- 29826477
TI  - Tinker or Prophet?

PMID- 29826478
TI  - A French Hospital: An Inside View.

PMID- 29826480
TI  - Annotations: Registered Plumbers.-Sea Water for Inland Towns.-Swimming Baths.

PMID- 29826479
TI  - Notes and News: Donations in Aid of the Proposed Cottage Hospital at
      Wellingborough.-The Study of Deep-Sea Animals.-Jubilee Memorial Cottage Hospital
      at Falkirk.-The Queen and the Women's Jubilee Offering.-The Launceston General
      Hospital, Tasmania. -Vacancies.-Scarlet Fever in London.-Munificent Donation to
      the Montrose Infirmary.-Decorations for Nuising Sisters.-The Edinburgh Roval
      Hospital for Sick Children.-Lady Brooke and the Southend Hospital. -The
      Bournemouth Hospital Scheme.- Meeting of the Hospital Saturday Fund Delegates.-
      The Hospitals Association Reference Library.- West Bromwich Hospital, etc.

PMID- 29826481
TI  - Blood-Making.

PMID- 29826482
TI  - Incidents of Animal Life.

PMID- 29826483
TI  - Farinaceous Foods.

PMID- 29826484
TI  - The National Pension Fund.

PMID- 29826485
TI  - Religio Medici.

PMID- 29826486
TI  - The Honoured Dead.

PMID- 29826487
TI  - The Armour Skeleton.

PMID- 29826489
TI  - The Sufferings of Christ.

PMID- 29826488
TI  - Dispensaries for Sailors.

PMID- 29826490
TI  - Annotations: Medical Students.-Medical Teachers. -Medical Examiners.

PMID- 29826491
TI  - The Sufferings of Christ.

PMID- 29826492
TI  - A Woman's Sacrifice.-For Duty's Sake.

PMID- 29826493
TI  - Kate Mountstephen: Chap. IV. Sister Katherine.

PMID- 29826494
TI  - Nursing Institutions, Nurses, and the Women's Jubilee Offering.

PMID- 29826495
TI  - Notes and News: Miscellaneous Items.-Dogs as Collectors.-Guessing Competitions.
      Hospital Fetes and Demonstrations.-Horncastle and the Lincoln County Hospital.
      The Brighton Dental Hospital.- Vacancies.-Volunteer Collectors.-The Folkestone
      Hospital Dispute.-The Royal Cornwall Infirmary.- The Pudsey Football Club.-The
      Workmen's Industrial Exhibition.-The Glasgow Medical Charities, etc., etc.

PMID- 29826496
TI  - Hospital Administration.-Alcohol and Milk Consumption.

PMID- 29826497
TI  - Where to Buy "The Hospital".

PMID- 29826498
TI  - A Matron's Corner.

PMID- 29826499
TI  - About Scarlet Fever.

PMID- 29826500
TI  - The Destruction of the Poor.

PMID- 29826501
TI  - King Solomon's Physic.

PMID- 29826502
TI  - Annotations: The Queen's Fund and the Pension Fund.-Twenty Thousand Hospital
      Supporters.- Working Men and Their Manners.

PMID- 29826504
TI  - Scarlet Fever.

PMID- 29826503
TI  - A New Home Hospital.

PMID- 29826506
TI  - Lunatic Literature.

PMID- 29826505
TI  - The National Pension Fund.

PMID- 29826507
TI  - Visiting Day.

PMID- 29826508
TI  - Something about Eyes.

PMID- 29826509
TI  - The New Journalism.

PMID- 29826510
TI  - Kate Mountstephen: Chapter II. "An Ounce of Practice".

PMID- 29826511
TI  - The Mission Parcel Society.

PMID- 29826512
TI  - Native Medical Practice in India.

PMID- 29826513
TI  - The Norfolk and Norwich Hospital.

PMID- 29826514
TI  - A "Matron's Corner".

PMID- 29826516
TI  - The Sufferings of Christ.

PMID- 29826515
TI  - Notes and News: Miscellaneous Items.-Scarlet Fever in the Metropolis.-Hospital
      Sunday Church Collections at Lowestoft.-"Queen Victoria's Bounty."-Church Parade
      Collections.-Vacancies.-The Tavistock Cottage Hospital.-Honorary Honorary
      Hospital Appointments.-The Gloucester Free Hospital, etc., etc.

PMID- 29826517
TI  - Safe from Scarlet Fever.

PMID- 29826518
TI  - The Sufferings of Christ.

PMID- 29826519
TI  - First Days in Africa.

PMID- 29826520
TI  - Kate Mountstephen: Chapter V.-The Hospital on Fire.

PMID- 29826521
TI  - Sceptical Doctors.

PMID- 29826522
TI  - St. Mary's and the Working Classes.

PMID- 29826524
TI  - Palmistry Notes.

PMID- 29826523
TI  - Massage and Medical Electricity.

PMID- 29826525
TI  - Hospital Administration.-Alcohol at Provincial Hospitals.

PMID- 29826527
TI  - A Divided House in a Cathedral City.

PMID- 29826526
TI  - Incidents of Animal Life.

PMID- 29826528
TI  - Annotations: Honest Yorkshire Farmers.-"The Cow with the Iron Tail."-Wholesale
      Poisoning.

PMID- 29826529
TI  - Notes and News: Miscellaneous Items. -Photographic Views and Albums.-The
      Hospitals Association Meetings.- The Bridgewater State Procession.- Vacancies.
      Sea-Water Baths, etc., etc.

PMID- 29826530
TI  - The National Pension Fund.

PMID- 29826531
TI  - In a Hospital Mortuary.

PMID- 29826532
TI  - Sympathetic Surgery.-I.

PMID- 29826533
TI  - The History and Capabilities of Herbal Simples: XVIII.-Chervil-Celandine; the
      Greater.

PMID- 29826535
TI  - A Question about Out-Patients.

PMID- 29826534
TI  - The London Is Bold.

PMID- 29826536
TI  - Everybody's Page.

PMID- 29826537
TI  - Diabetes.

PMID- 29826539
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826538
TI  - Salvation.

PMID- 29826541
TI  - Ear Disease.

PMID- 29826540
TI  - The Story of the Insane from Year to Year.

PMID- 29826542
TI  - Nephrolithotomy.

PMID- 29826543
TI  - Annotations.

PMID- 29826545
TI  - Cancer Curers.

PMID- 29826544
TI  - Leprosy Investigation.

PMID- 29826546
TI  - Chronic Bright's Disease.

PMID- 29826547
TI  - Recent Research.

PMID- 29826548
TI  - Notes and News.

PMID- 29826549
TI  - Working Women in Large Towns: X. Domestic Servants.

PMID- 29826551
TI  - Out-Patients in Hospitals.

PMID- 29826550
TI  - Commonplace.

PMID- 29826553
TI  - New Drugs, Appliances, and Things Medical: Bontha.

PMID- 29826552
TI  - The History and Capabilities of Herbal Simples: XIX.-The Horse Chestnut.

PMID- 29826554
TI  - Everybody's Page.

PMID- 29826555
TI  - God's Ministers.

PMID- 29826556
TI  - Annotations.

PMID- 29826557
TI  - The Treatment of Cysts.

PMID- 29826558
TI  - Abscess of Bone.

PMID- 29826559
TI  - Zenana Bible and Medical Mission.

PMID- 29826560
TI  - Sympathetic Surgery.-II.

PMID- 29826561
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826562
TI  - A Canterbury Tale.

PMID- 29826563
TI  - Optic Neuritis.

PMID- 29826564
TI  - Guinea-Worm.

PMID- 29826565
TI  - Working Women in Large Towns: XI.-Shop Assistants.

PMID- 29826566
TI  - An Endless Quest.

PMID- 29826567
TI  - Notes and News.

PMID- 29826568
TI  - Carcinoma of the Larynx.

PMID- 29826569
TI  - Vesical Tumours.

PMID- 29826570
TI  - The Story of the Insane from Year to Year.

PMID- 29826571
TI  - Pulsating Exophthalmos.

PMID- 29826572
TI  - Solution of Gall Stones.

PMID- 29826573
TI  - Notes and News.

PMID- 29826574
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826575
TI  - Epsom College.

PMID- 29826576
TI  - A Rare Case of Symblepharon.

PMID- 29826577
TI  - The New Hospital for Women.

PMID- 29826578
TI  - A Dead Journalist.

PMID- 29826579
TI  - Annotations.

PMID- 29826581
TI  - Aspiration in Pneumothorax.

PMID- 29826580
TI  - Neurotic Pruritus.

PMID- 29826582
TI  - Sodium versus Potassium Salts.

PMID- 29826583
TI  - Cystotomy and Cystectomy.

PMID- 29826585
TI  - Everybody's Page.

PMID- 29826584
TI  - Education and Benevolence for Doctors.

PMID- 29826586
TI  - May.

PMID- 29826587
TI  - Pneumotomy.

PMID- 29826588
TI  - Poisoning by Bad Meat.

PMID- 29826589
TI  - Inflammatory Exophthalmos.

PMID- 29826590
TI  - Patience.

PMID- 29826591
TI  - The Sussex County Hospital.

PMID- 29826592
TI  - Phosphorus Necrosis.

PMID- 29826593
TI  - The History and Capabilities of Herbal Simples: VIII.-Blackberries-Brooklime.

PMID- 29826594
TI  - Paralysis after Diphtheria.

PMID- 29826595
TI  - Glaucoma in Early Life.

PMID- 29826596
TI  - Splenectomy.

PMID- 29826597
TI  - Salicylates in Pleurisy.

PMID- 29826598
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826599
TI  - More Life and Fuller.

PMID- 29826600
TI  - Annotations.

PMID- 29826601
TI  - Life in the New Hebrides.

PMID- 29826602
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29826603
TI  - The Story of the Insane from Year to Year.

PMID- 29826604
TI  - Antipyrin.

PMID- 29826605
TI  - Free Trade in Medicine.

PMID- 29826606
TI  - At the Lords' Committee.

PMID- 29826607
TI  - Diarrhoea.

PMID- 29826608
TI  - Heart Disease in Children.

PMID- 29826609
TI  - Working Women in Large Towns: IX. Domestic Servants.

PMID- 29826611
TI  - Notes and News.

PMID- 29826610
TI  - The Attack on the Matron of the London: The Governors Support the House
      Committee.

PMID- 29826612
TI  - Foods, Drugs, Instruments, &c.

PMID- 29826613
TI  - Failure.

PMID- 29826614
TI  - September.

PMID- 29826615
TI  - Everybody's Page.

PMID- 29826616
TI  - Working Women in Large Towns: II. Street Workers.

PMID- 29826617
TI  - Vaccination in Italy.

PMID- 29826618
TI  - Do the Sick Fear Death?

PMID- 29826619
TI  - Notes and News.

PMID- 29826621
TI  - A Standard of Sanity.

PMID- 29826620
TI  - Patience in Sickness.

PMID- 29826622
TI  - Annotations.

PMID- 29826623
TI  - Retiring Allowances to Charity Officials.

PMID- 29826624
TI  - Pelvic Inflammation.

PMID- 29826625
TI  - Addison's Disease.

PMID- 29826626
TI  - A Doctor "On the Stump".

PMID- 29826627
TI  - Watching the Insane by Reflecting Shafts.

PMID- 29826628
TI  - Stroud General Hospital.

PMID- 29826629
TI  - Everybody's Page.

PMID- 29826630
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826631
TI  - Annotations.

PMID- 29826633
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826632
TI  - Notes and News.

PMID- 29826634
TI  - Tropical Diarrhoea.

PMID- 29826635
TI  - The Two Knowledges.

PMID- 29826636
TI  - The Gateways of Medicines.

PMID- 29826637
TI  - Excision of the Mamma under Hypnotic Anaesthesia.

PMID- 29826638
TI  - Come.

PMID- 29826639
TI  - Short Trips for Short Holidays: I. The Norman Archipelago.

PMID- 29826640
TI  - Work, Play, and Success.

PMID- 29826641
TI  - Sunflowers as an Antiperiodic.

PMID- 29826642
TI  - Everybody's Page.

PMID- 29826643
TI  - Zenana Medical Mission.

PMID- 29826644
TI  - The B.M.A. and the B.N.A.

PMID- 29826645
TI  - Plucked!

PMID- 29826646
TI  - An American Medical Journal.

PMID- 29826647
TI  - Recent Therapeutics.

PMID- 29826648
TI  - The History and Capabilities of Herbal Simples: XVII.-Chickweed and Groundsel.

PMID- 29826650
TI  - Notes and News.

PMID- 29826649
TI  - Reparation of Bone after Trephining.

PMID- 29826651
TI  - Annotations.

PMID- 29826652
TI  - The Hebrew Wards at the London Hospital.

PMID- 29826654
TI  - Use of Alcohol.

PMID- 29826653
TI  - Stricter Control.

PMID- 29826656
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826655
TI  - Before the Lords' Committee: IV.-Mr. William Bousfield and Dr. W. B. Clarke.

PMID- 29826657
TI  - Those That Travel by Water.

PMID- 29826658
TI  - Skin Grafting.

PMID- 29826659
TI  - Everybody's Page.

PMID- 29826660
TI  - A Dangerous Hospital.

PMID- 29826661
TI  - Administration of Santonin.

PMID- 29826662
TI  - Iodide of Calcium as an Antiseptic.

PMID- 29826663
TI  - Redemption.

PMID- 29826664
TI  - Working Women in Large Towns. IV: Class II. Factory and Workroom Hands.

PMID- 29826666
TI  - A Wage Limit for In-Patients.

PMID- 29826665
TI  - Midwives of Old.

PMID- 29826668
TI  - A Tale of Chivalry.

PMID- 29826667
TI  - New Drugs, Appliances, and Things Medical: Messrs. Down Brothers' Surgical
      Instruments.

PMID- 29826670
TI  - Mesmerism at the Westminster Aquarium.

PMID- 29826669
TI  - The Derby Infirmary.

PMID- 29826671
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826672
TI  - Hypnotism.

PMID- 29826673
TI  - Working Women in Large Towns: V. Women as Tailors.

PMID- 29826674
TI  - Question No. 23.

PMID- 29826675
TI  - Prayer.

PMID- 29826676
TI  - Everybody's Page.

PMID- 29826677
TI  - Annotations.

PMID- 29826678
TI  - Before the Lords' Committee: V. Sir Sydney H. Waterlow, Bart.

PMID- 29826679
TI  - The History and Capabilities of Herbal Simples: XII.-Buckthorn.

PMID- 29826680
TI  - Recent Views of Enteric Fever.

PMID- 29826681
TI  - The Medical Calf.

PMID- 29826682
TI  - Notes and News.

PMID- 29826683
TI  - The Year's Work of the Medical Charities of London.

PMID- 29826684
TI  - A Christian City.

PMID- 29826685
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826686
TI  - Hospitals and Sick Children.

PMID- 29826687
TI  - Imperial Provision for the Sick.

PMID- 29826688
TI  - Do the Sick Fear Death?

PMID- 29826689
TI  - Before the Lords' Committee: II.-Some Interesting Facts.

PMID- 29826691
TI  - Wearisome Days.

PMID- 29826690
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826692
TI  - Notes and News.

PMID- 29826693
TI  - The Military Exhibition.

PMID- 29826695
TI  - Glances at Foreign Asylums.

PMID- 29826694
TI  - Everybody's Page.

PMID- 29826696
TI  - Golden Pheasants and Clerical Guns.

PMID- 29826697
TI  - Annotations.

PMID- 29826699
TI  - Annotations.

PMID- 29826698
TI  - Everybody's Page.

PMID- 29826700
TI  - Cannabis Indica.

PMID- 29826701
TI  - The Month of May in India.

PMID- 29826702
TI  - Progress of Surgery.

PMID- 29826703
TI  - Cremation or "Decent Burial"?

PMID- 29826705
TI  - Working Women in Large Towns: III. Factory Girls.

PMID- 29826704
TI  - Before the Lords' Committee.

PMID- 29826706
TI  - Weary Nights.

PMID- 29826707
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826709
TI  - Myxoedema.

PMID- 29826708
TI  - Notes and News.

PMID- 29826711
TI  - Charitable Trusts and Charity Commissioners.

PMID- 29826710
TI  - The London Post-Graduate Course.

PMID- 29826712
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826713
TI  - Glances at Foreign Asylums.

PMID- 29826714
TI  - Twelve English Statesmen: William I., Henry II., and Henry VII.

PMID- 29826715
TI  - Antisepsine.

PMID- 29826716
TI  - Phosphorus in Rickets.

PMID- 29826717
TI  - Notes and News.

PMID- 29826719
TI  - Temporary Resection of the Skull.

PMID- 29826718
TI  - Everybody's Page.

PMID- 29826721
TI  - Diet in Gout.

PMID- 29826720
TI  - Paracresotinic Acid.

PMID- 29826722
TI  - Treatment of Traumatic Tetanus by Subcutaneous Injection of Carbolic Acid.

PMID- 29826723
TI  - Treatment of Varicose Veins by Enucleation.

PMID- 29826724
TI  - Indirect Mortality from Influenza.

PMID- 29826725
TI  - The Prevention of Orphanhood.

PMID- 29826726
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29826727
TI  - June.

PMID- 29826729
TI  - Before the Lords' Committee: III.-Mr. Timothy Holmes, Mr. Nelson Hardy, and Mr.
      Hugh Woods.

PMID- 29826728
TI  - The History and Capabilities of Herbal Simples: XI.-White Byrony.

PMID- 29826730
TI  - When Ought Appeals to Cease?

PMID- 29826731
TI  - Calomel in Cardiac Dropsy.

PMID- 29826733
TI  - Annotations.

PMID- 29826732
TI  - Diuretin.

PMID- 29826735
TI  - A New Antidote for Morphine.

PMID- 29826734
TI  - Salicylates.

PMID- 29826736
TI  - Atropine in Poisoning by Aconite.

PMID- 29826737
TI  - A Physician's Apologia.

PMID- 29826738
TI  - Reading the Scriptures.

PMID- 29826739
TI  - A Provident Out-Patient Department.

PMID- 29826740
TI  - Annotations.

PMID- 29826741
TI  - Notes and News.

PMID- 29826743
TI  - Surgical Treatment of Diphtheria.

PMID- 29826742
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826745
TI  - The Qualification Question.

PMID- 29826744
TI  - Plausibility or Honesty?

PMID- 29826746
TI  - Aix-Les-Bains.

PMID- 29826747
TI  - Jottings from Sweden and Denmark.

PMID- 29826748
TI  - The History and Capabilities of Herbal Simples: IX.-Borage.

PMID- 29826749
TI  - Hepatic Fever.

PMID- 29826750
TI  - Friend and Foe.

PMID- 29826751
TI  - Everybody's Page.

PMID- 29826752
TI  - New Drugs, Appliances, and Things Medical: "Vinolia" Toilet Soap.

PMID- 29826754
TI  - Medicinal Soap.

PMID- 29826753
TI  - Country v. Town Practice.

PMID- 29826755
TI  - Helps to Gain Patience.

PMID- 29826756
TI  - On the March.

PMID- 29826758
TI  - Nature of Phthisis, 235.

PMID- 29826757
TI  - Is Marriage a Sin?

PMID- 29826760
TI  - Everybody's Page.

PMID- 29826759
TI  - Spelthorne Sanatorium.

PMID- 29826761
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826762
TI  - Annotations.

PMID- 29826764
TI  - Notes and News.

PMID- 29826763
TI  - General Charities.

PMID- 29826765
TI  - Probationer Nurses.

PMID- 29826766
TI  - Prayer for Recovery.

PMID- 29826768
TI  - Unreduced Dislocations of the Femur.

PMID- 29826767
TI  - The History and Capabilities of Herbal Simples: XV.-Celandine-Celery.

PMID- 29826770
TI  - Ovariotomy.

PMID- 29826769
TI  - Ureametry.

PMID- 29826772
TI  - Malarious Haemophilia.

PMID- 29826771
TI  - Before the Lords' Committee: VII.-Nursing at the London Hospital.

PMID- 29826773
TI  - Sudden Deaths in Laryngeal Disease.

PMID- 29826774
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29826775
TI  - Popliteal Aneurysm.

PMID- 29826776
TI  - Inebriety.

PMID- 29826777
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826778
TI  - The Sussex County Hospital, Brighton.

PMID- 29826779
TI  - Everybody's Page.

PMID- 29826780
TI  - Death.

PMID- 29826781
TI  - Epilepsy.

PMID- 29826782
TI  - Annotations.

PMID- 29826783
TI  - Baden-Baden.

PMID- 29826784
TI  - A Gossip about Pills.

PMID- 29826785
TI  - Medical Relief in London.

PMID- 29826786
TI  - Notes and News.

PMID- 29826787
TI  - A Skulking Accuser.

PMID- 29826788
TI  - The General Infirmary, Gloucester.

PMID- 29826789
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29826790
TI  - Vaccination in Germany.

PMID- 29826791
TI  - Tracheotomy.

PMID- 29826792
TI  - The Provident Principle in Connection with Hospitals.

PMID- 29826794
TI  - Notes and News.

PMID- 29826793
TI  - Annotations.

PMID- 29826795
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29826796
TI  - Gastric Catarrh.

PMID- 29826798
TI  - Women's Uncongenial Occupations.

PMID- 29826797
TI  - The C.O.S. and the Preparation of Charitable Accounts.

PMID- 29826799
TI  - The Bacillus of Typhoid.

PMID- 29826800
TI  - Country Roads.

PMID- 29826801
TI  - The History and Capabilities of Herbal Simples: VII. Wood Betony.

PMID- 29826802
TI  - Renal Calculus.

PMID- 29826803
TI  - Colotomy.

PMID- 29826805
TI  - A Hint from America.

PMID- 29826804
TI  - School of Science v. Society of Science, Letters, and Art of London.

PMID- 29826807
TI  - Hysteria and Organic Disease.

PMID- 29826806
TI  - The Children's Hospital, Birmingham.

PMID- 29826808
TI  - Calomel for Diphtheria.

PMID- 29826809
TI  - The Lord Is Risen.

PMID- 29826811
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826810
TI  - Everybody's Page.

PMID- 29826812
TI  - Enlarged Glands.

PMID- 29826813
TI  - Histeria.

PMID- 29826815
TI  - A Visit to the Hospital at Zurich University.

PMID- 29826814
TI  - The Sanitary Condition of the London Hospital.

PMID- 29826816
TI  - Truth.

PMID- 29826817
TI  - Annotations.

PMID- 29826819
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826818
TI  - Royal Medical Benevolent College.

PMID- 29826821
TI  - New Drugs. Appliances, and Things Medical: The Automatic Respirator.

PMID- 29826820
TI  - The Dangers of Kissing.

PMID- 29826822
TI  - The New Disease, "Nona".

PMID- 29826823
TI  - Science and a Future Life.

PMID- 29826825
TI  - Typhlitis.

PMID- 29826824
TI  - Notes and News.

PMID- 29826827
TI  - Acute Tonsilitis.

PMID- 29826826
TI  - Cares and Coffins.

PMID- 29826829
TI  - Everybody's Page.

PMID- 29826828
TI  - The Connection of Burns with Ulceration of the Duodenum.

PMID- 29826830
TI  - April.

PMID- 29826831
TI  - Doctoring John Chinaman.

PMID- 29826832
TI  - Scaff's Leather and Rubber Boots.

PMID- 29826833
TI  - Retiring Allowances to Charity Officials.

PMID- 29826834
TI  - Gangrene.

PMID- 29826835
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826836
TI  - Royal Medical Benevolent College, Epsom.

PMID- 29826837
TI  - Constipation.

PMID- 29826838
TI  - Examination of the Liver.

PMID- 29826839
TI  - "For the Complexion" : A Rival to Pears.

PMID- 29826841
TI  - Sclerema and OEdema Neonatorum.

PMID- 29826840
TI  - A Hospital Inquisition.

PMID- 29826842
TI  - Description of the New Hospital Wings of the Royal Asylum, Perth.

PMID- 29826843
TI  - The Power of Pain.

PMID- 29826844
TI  - Annotations.

PMID- 29826845
TI  - Notes and News.

PMID- 29826846
TI  - Working Women in Large Towns: I. In England and in America.

PMID- 29826847
TI  - Glances at Foreign Asylums.

PMID- 29826848
TI  - Home and Pay Hospitals: Mr. Burdett on the Pay System.

PMID- 29826849
TI  - Notes and News.

PMID- 29826850
TI  - How Suicides Are Made.

PMID- 29826851
TI  - Life in a London Hospital. I.

PMID- 29826852
TI  - Spina Bifida.

PMID- 29826853
TI  - Everybody's Page.

PMID- 29826854
TI  - A New Medical Term.

PMID- 29826856
TI  - Annotations.

PMID- 29826855
TI  - The History and Capabilities of Herbal Simples: XVI.-Camomile.

PMID- 29826857
TI  - Kindness Shown in Suffering.

PMID- 29826858
TI  - Gas Poisoning.

PMID- 29826859
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826860
TI  - Example before Precept.

PMID- 29826862
TI  - New Drugs, Appliances, and Things Medical: Aerated Waters.

PMID- 29826861
TI  - Before the Lords' Committee: VIII. The Nurses of the London Hospital.

PMID- 29826863
TI  - A Mean and Miserable Diet.

PMID- 29826864
TI  - Recent Views of Leprosy.

PMID- 29826865
TI  - Notes and News.

PMID- 29826866
TI  - Trivialities.

PMID- 29826867
TI  - Fair Play.

PMID- 29826868
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826869
TI  - Baby Brains.

PMID- 29826870
TI  - Everybody's Page.

PMID- 29826871
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29826872
TI  - Submission.

PMID- 29826873
TI  - The Metropolitan Hospital Sunday Fund, 1890.

PMID- 29826874
TI  - Nephrolithotomy.

PMID- 29826876
TI  - Recent Research.

PMID- 29826875
TI  - Before the Lords' Committee: IX.-Hospital and District Work.

PMID- 29826877
TI  - The Neglect of the Poor in Workhouse Infirmaries.

PMID- 29826878
TI  - Annotations.

PMID- 29826879
TI  - Nocturnal Incontinence of Children.

PMID- 29826880
TI  - Editor's Letter-Box.

PMID- 29826881
TI  - Annotations.

PMID- 29826882
TI  - Race Rivalries.

PMID- 29826884
TI  - Goitre Treated by Electricity.

PMID- 29826883
TI  - Everybody's Page.

PMID- 29826885
TI  - Insect Stings.

PMID- 29826886
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29826887
TI  - Treatment of Fractured Legs.

PMID- 29826888
TI  - The Moral Basis of Private Property: II.-The Good of the Community.

PMID- 29826889
TI  - Working Women in Large Towns: VII. Matchbox, Brush, and Box Makers.

PMID- 29826890
TI  - Notes and News.

PMID- 29826892
TI  - Unbelief.

PMID- 29826891
TI  - Abroad and at Home.

PMID- 29826893
TI  - A New Name, If Not a New Disease.

PMID- 29826894
TI  - Hemiplegia in Pneumonia of Children.

PMID- 29826895
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826896
TI  - Frivolity's Labours.

PMID- 29826897
TI  - New Drugs, Appliances, and Things Medical: The "Rapid" Clinical Thermometer.

PMID- 29826898
TI  - Resorcin.

PMID- 29826900
TI  - Nitrate of Silver in Tabes.

PMID- 29826899
TI  - Advantages of Warm Sublimate Solutions.

PMID- 29826902
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826901
TI  - The History and Capabilities of Herbal Simples: XIII.-The Cabbage.

PMID- 29826903
TI  - Can Tropical Africa Be Colonised?

PMID- 29826904
TI  - OEdima Glottidis as a Result of Iodism.

PMID- 29826905
TI  - As Might Be Reasonably Expected.

PMID- 29826906
TI  - Exalgin.

PMID- 29826907
TI  - Absorption of Fat.

PMID- 29826908
TI  - Insanity Cured by Influenza.

PMID- 29826909
TI  - Before the Lords' Committee: VI. Sir Sydney Waterlow.

PMID- 29826910
TI  - Sulphonal in Diabetes.

PMID- 29826911
TI  - Annotations.

PMID- 29826912
TI  - July.

PMID- 29826913
TI  - Everybody's Page.

PMID- 29826914
TI  - The Bacillus of Diphtheria.

PMID- 29826915
TI  - Hope.

PMID- 29826916
TI  - Mountain or Sea?

PMID- 29826917
TI  - Resection of the Lungs.

PMID- 29826918
TI  - A Modern Miracle.

PMID- 29826919
TI  - Notes and News.

PMID- 29826920
TI  - A New Nasal Douche.

PMID- 29826922
TI  - Care.

PMID- 29826921
TI  - Injection of Varicose Veins.

PMID- 29826923
TI  - Notes and News.

PMID- 29826924
TI  - Thoughts on Ill-Health: II. Audi Alteram Partem.

PMID- 29826925
TI  - The Fairy Tales of Science.

PMID- 29826926
TI  - Dr. Bevan Rake on Leprosy.

PMID- 29826928
TI  - Valued Officials.

PMID- 29826927
TI  - New Drugs, Appliances, and Things Medical: Bovril-Florador.

PMID- 29826929
TI  - Everybody's Page.

PMID- 29826931
TI  - An Interview with Mrs. Dacre Craven (With Portrait).

PMID- 29826930
TI  - The Metropolitan Workhouse Infirmaries: Resolution of the Paddington Board of
      Guardians.

PMID- 29826933
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826932
TI  - Gastrotomy.

PMID- 29826935
TI  - The Expansion of Medicine.

PMID- 29826934
TI  - Annotations.

PMID- 29826937
TI  - Thoughts on Ill-Health: III. Moral Health.

PMID- 29826936
TI  - Dangerous Lunatics at Large.

PMID- 29826939
TI  - Metropolitan Workhouse Infirmaries.

PMID- 29826938
TI  - Annotations.

PMID- 29826940
TI  - Albuminuria and Life Assurance.

PMID- 29826941
TI  - Notes and News.

PMID- 29826942
TI  - Wasted Opportunities.

PMID- 29826943
TI  - Cholera Prevention.

PMID- 29826944
TI  - Use of Ether.

PMID- 29826945
TI  - Foods, Drugs, Instruments, &c.

PMID- 29826946
TI  - New Drugs, Appliances, and Things Medical: Knight's Antiseptic Eucalyptus
      Tablets.

PMID- 29826947
TI  - Use of Aloes.

PMID- 29826949
TI  - Everybody's Page.

PMID- 29826948
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826950
TI  - Working Women in Large Towns: VIII. Shirt, Sack, and Umbrella Makers.

PMID- 29826951
TI  - Consumption: A Step Forward.

PMID- 29826953
TI  - Salol.

PMID- 29826952
TI  - A Hospital in the Black Forest.

PMID- 29826954
TI  - Venesection.

PMID- 29826955
TI  - The Treatment of Diabetes.

PMID- 29826956
TI  - Lanolin.

PMID- 29826957
TI  - Poisoning by Antifebrin.

PMID- 29826959
TI  - Annotations.

PMID- 29826958
TI  - Tested by Results.

PMID- 29826960
TI  - Injections of Ether in Neuralgia.

PMID- 29826961
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826962
TI  - God's Hand.

PMID- 29826963
TI  - Everybody's Page.

PMID- 29826965
TI  - Prevention of the Toxic Effects of Cocaine.

PMID- 29826964
TI  - "The Lancet" and Hospital Nurses.

PMID- 29826967
TI  - Cure of Cancer by Erysipelas.

PMID- 29826966
TI  - Bright's Disease and Life Insurance.

PMID- 29826968
TI  - August.

PMID- 29826969
TI  - Notes and News.

PMID- 29826970
TI  - Thoughts on Ill-Health: I. Not Quite "Fit".

PMID- 29826971
TI  - Before the Lords' Committee: X.-The Last of This Session.

PMID- 29826972
TI  - Restoration of Bone after Trephining.

PMID- 29826973
TI  - Life in a London Hospital. II.

PMID- 29826974
TI  - The Man and the Book.

PMID- 29826975
TI  - Annotations.

PMID- 29826976
TI  - Albuminaria.

PMID- 29826977
TI  - Right or Left?

PMID- 29826978
TI  - Extra Supplement-The Nursing Mirror.

PMID- 29826979
TI  - Podophyllin Poisoning.

PMID- 29826980
TI  - A Fortunate Hospital.

PMID- 29826981
TI  - Cure of Arterio Venous Aneurism by Extirpation.

PMID- 29826982
TI  - Arterial Suture.

PMID- 29826984
TI  - Hepatic Surgery.

PMID- 29826983
TI  - North-Eastern Hospital for Children.

PMID- 29826985
TI  - The New Lunacy Laws.

PMID- 29826986
TI  - The Princess and the First Thousand.

PMID- 29826987
TI  - Effects of Arsenic.

PMID- 29826988
TI  - The History and Capabilities of Herbal Simples: XIV.-Carraway-Carrot.

PMID- 29826990
TI  - Notes and News.

PMID- 29826989
TI  - Working Women in Large Towns: VI. Needlewomen-Fur Sewers, etc.

PMID- 29826992
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29826991
TI  - Hot Air Treatment of Phthisis.

PMID- 29826993
TI  - The Burthen of Life.

PMID- 29826994
TI  - Electric Prostration.

PMID- 29826996
TI  - A Substitute for Quinine.

PMID- 29826995
TI  - Powders in Papers.

PMID- 29826998
TI  - Hospital and Institutional News.

PMID- 29826997
TI  - Everybody's Page.

PMID- 29826999
TI  - The Evolution of a City Hospital: Mr. Arthur Hulme on the Queen's Hospital,
      Birmingham.

PMID- 29827000
TI  - The X-Rays.

PMID- 29827002
TI  - Hospital Needs.

PMID- 29827001
TI  - Hospitals and the State: Sir William Collins' Paper and the Discussion.

PMID- 29827004
TI  - Personalities at the Conference: An Impression from the Hearers' Point of View.

PMID- 29827003
TI  - The Institutional Worker.

PMID- 29827005
TI  - An International Hospital Congress.

PMID- 29827006
TI  - The Draft Poor-Law Order.

PMID- 29827008
TI  - Hospital Needs.

PMID- 29827007
TI  - Conference at Birmingham: Full Report of the Proceedings and Discussions.

PMID- 29827009
TI  - Anaesthesia in American Hospitals.

PMID- 29827010
TI  - Medical Officers under the Poor Law.

PMID- 29827011
TI  - Operations and Christian Science.

PMID- 29827012
TI  - The General Hospitals of the Territorial Army.

PMID- 29827013
TI  - The Administration of Drugs to Nursing Mothers.

PMID- 29827014
TI  - Fatal Accident to a Senior Physician.

PMID- 29827015
TI  - To Medical Freemasons.

PMID- 29827016
TI  - The Legal Position as to Medical Benefit.

PMID- 29827017
TI  - The Auxiliary Symptoms of Early Organic Heart Disease.

PMID- 29827018
TI  - Research and Remedies.

PMID- 29827019
TI  - The Inefficient Cook-From a Matron's Point of View.

PMID- 29827020
TI  - Welsh Firms and the Insurance Act.

PMID- 29827021
TI  - Hospital and Institutional News.

PMID- 29827022
TI  - The New Nelson Hospital, Wimbledon.

PMID- 29827023
TI  - Employees and the National Insurance Act: XXVIII. The Contract of Membership of
      Approved Societies.

PMID- 29827024
TI  - In an East Borneo Hospital.-II.

PMID- 29827026
TI  - The Red Cross Society in Yorkshire.

PMID- 29827025
TI  - Premature Burial Precautions.

PMID- 29827028
TI  - The "Mucous Disease" of Children: A Summary of Symptoms and Treatment.

PMID- 29827027
TI  - The Institutional Worker.

PMID- 29827029
TI  - The Metropolitan Hospital Sunday Fund: Report and Awards of the Distribution
      Committee.

PMID- 29827030
TI  - Cooling Drinks with Simple Recipes.

PMID- 29827032
TI  - Hospital and Institutional News.

PMID- 29827031
TI  - The X-Rays.

PMID- 29827033
TI  - The Library.-I.

PMID- 29827034
TI  - The Hospitals of Insulinde: Their Construction, Administration, and Mortality.

PMID- 29827035
TI  - The Reform of Out-Patients.

PMID- 29827036
TI  - The General Practitioner and Sanatorium Benefit.

PMID- 29827037
TI  - The Institutional Worker.

PMID- 29827038
TI  - Acute Pancreatitis-III: Its Diagnosis and Surgical Treatment.

PMID- 29827039
TI  - Research and Remedies.

PMID- 29827040
TI  - Employees and the National Insurance Act: XXII. Substituted Benefits.

PMID- 29827041
TI  - Legal Notes for Institutional Workers.

PMID- 29827042
TI  - The Institutional Worker.

PMID- 29827044
TI  - The Advance of the Poor-Law Infirmary: Dr. W. R. Jordan on the Value of a
      Visiting Staff.

PMID- 29827043
TI  - Comfortable Meals in an Institution-Supper.

PMID- 29827045
TI  - Hospital Construction in Germany.

PMID- 29827047
TI  - Doctors' Fees and Nursing Homes.

PMID- 29827046
TI  - The X-Rays.

PMID- 29827049
TI  - Employees and the National Insurance Act: XXIV. The Financial Provisions.

PMID- 29827048
TI  - Preventive Methods in Provincial Institutions.

PMID- 29827050
TI  - Hospital and Institutional News.

PMID- 29827051
TI  - Wasted Holidays.

PMID- 29827052
TI  - The Mortuary Unit. Some Preliminary Considerations-I.

PMID- 29827053
TI  - The Library.-II.

PMID- 29827054
TI  - East Suffolk Hospital, Ipswich.

PMID- 29827055
TI  - Post-Graduate Study in Medicine.-I: The Continental and English Systems of Study
      Compared.

PMID- 29827057
TI  - Government-Guaranteed Sera: A National Need.

PMID- 29827056
TI  - The King's Wish.

PMID- 29827058
TI  - The Institutional Worker.

PMID- 29827059
TI  - The New Research Hospital at Cambridge: Its Development, Opening, and Aims.

PMID- 29827060
TI  - Employees and the National Insurance Act: XIII. The Insurance of Hospital Nurses.

PMID- 29827061
TI  - Research and Remedies.

PMID- 29827062
TI  - The Ward Laboratory versus the Institutional Laboratory.

PMID- 29827064
TI  - Dry Heat and Conservative Cooking.

PMID- 29827063
TI  - A Sixty-Hour Week for Mental Hospital Workers.

PMID- 29827065
TI  - The Planning of Institution Laundries.

PMID- 29827066
TI  - The Problem of the Elderly Primipara.

PMID- 29827067
TI  - Hospital and Institutional News.

PMID- 29827068
TI  - St. George's Hospital and King Edward's Fund.

PMID- 29827069
TI  - Special Hospitals and Their Advertisements.

PMID- 29827070
TI  - Professional Conduct in the Seventeenth Century.

PMID- 29827071
TI  - A New Compendium of Treatment: Medical and Surgical Therapeutics of To-Day.

PMID- 29827072
TI  - Manual of Surgical Treatment.

PMID- 29827073
TI  - The Institutional Worker.

PMID- 29827074
TI  - The Diagnosis of Smallpox.

PMID- 29827075
TI  - A Motor-Cycle in a Country Practice: Its Specifications and Value to the General
      Practitioner.

PMID- 29827076
TI  - Derby Day and "Recreative Betting."

PMID- 29827077
TI  - Hospital and Institutional News.

PMID- 29827078
TI  - The X-Rays.

PMID- 29827079
TI  - The Housekeeper's Time-Table.

PMID- 29827081
TI  - Who Should Be Responsible for Its Support?

PMID- 29827080
TI  - Hospital Managers and the Insurance Act.

PMID- 29827082
TI  - Employees and the National Insurance Act: XIV. The Domestic Staffs in Hospitals.

PMID- 29827083
TI  - The Relation of Medical Men to Nurses.

PMID- 29827085
TI  - The Operative Treatment of Acute Epididymo-Orchitis.

PMID- 29827084
TI  - Cure by Obliteration.

PMID- 29827086
TI  - A Novel Caesarean Section.

PMID- 29827087
TI  - Hospital and Institutional News.

PMID- 29827088
TI  - Research and Remedies.

PMID- 29827089
TI  - The Royal Infirmary, Sunderland.

PMID- 29827090
TI  - Cremation: Its Cost and How It Is Carried out.

PMID- 29827091
TI  - Employees and the National Insurance Act: V. Benefits Receivable under the Act.

PMID- 29827093
TI  - Territorial Compensation for Injuries.

PMID- 29827092
TI  - The Ward Floor in All Materials.

PMID- 29827094
TI  - A Comparison of Prices Paid by London Hospitals for Their Food Supplies.-I.

PMID- 29827095
TI  - The Institutional Worker.

PMID- 29827096
TI  - The Silence of the Insurance Commission.

PMID- 29827097
TI  - Legal Notes for Institutional Workers.

PMID- 29827098
TI  - Premature Burial and the Law.

PMID- 29827100
TI  - Nature Notes.-X.

PMID- 29827099
TI  - Hospital Staffs and Fees at Inquests.

PMID- 29827101
TI  - The Select Committee on Secret Remedies.

PMID- 29827102
TI  - Our Insurance Act Department.

PMID- 29827104
TI  - The Management of Creches and Day Nurseries: A Critical Comparison, with
      Suggested Reforms.

PMID- 29827103
TI  - Out-Patients and Solicitors' Touts.

PMID- 29827105
TI  - Premature Burial and the Law.

PMID- 29827107
TI  - Cerebral Haemorrhage.-II.

PMID- 29827106
TI  - The Institutional Worker.

PMID- 29827109
TI  - Departments Which Do Not Always Pay.

PMID- 29827108
TI  - A Metropolitan Police Hospital.

PMID- 29827110
TI  - Hospital Accommodation on Merchant Ships.

PMID- 29827111
TI  - The Ward Bathroom in Design and Detail.

PMID- 29827112
TI  - Employees and the National Insurance Act: VII. Benefits Receivable under the Act.

PMID- 29827113
TI  - Hospital and Institutional News.

PMID- 29827115
TI  - Employees and the National Insurance Act: XV. The Domestic Staffs in Hospitals.

PMID- 29827114
TI  - The X-Rays.

PMID- 29827116
TI  - Residential Institutions for Mental Defectives.

PMID- 29827117
TI  - The Ward Ceiling, the Roof and Walls.

PMID- 29827118
TI  - The Work-Room: Hints on Repairing.

PMID- 29827119
TI  - Medical Education under Home Rule.

PMID- 29827120
TI  - Post-Graduate Study in Medicine.-II: The Continental and English Systems of Study
      Compared.

PMID- 29827121
TI  - Research and Remedies.

PMID- 29827122
TI  - The Modernising of Old Buildings.

PMID- 29827124
TI  - The "Genius Loci" and the Patient.

PMID- 29827123
TI  - The King and Queen Privately Attend the Morning Service.

PMID- 29827126
TI  - A Hospital Function at the Mansion House: The Dinner in Aid of St. Bartholomew's
      Hospital.

PMID- 29827125
TI  - Hospital and Institutional News.

PMID- 29827128
TI  - The Institutional Worker.

PMID- 29827127
TI  - The Insurance of Nurses.

PMID- 29827129
TI  - Special Hospitals and Their Advertisements.

PMID- 29827130
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29827132
TI  - The Institutional Worker.

PMID- 29827131
TI  - Dispensers under the Insurance Act.

PMID- 29827133
TI  - Research and Remedies.

PMID- 29827134
TI  - Health Insurance and Preventive Medicine.

PMID- 29827135
TI  - Economy of Labour in Hospital Management: An Assistant Secretary's Further
      Suggestions.

PMID- 29827136
TI  - Acute Pancreatitis-II: Its Diagnosis and Surgical Treatment.

PMID- 29827137
TI  - A School Doctor on the General Practitioner.

PMID- 29827139
TI  - Comfortable Meals in an Institution-Tea.

PMID- 29827138
TI  - The Prevention of Cross-Infection: The "Barrier" System at Ham Green Fever
      Hospital, Bristol.

PMID- 29827140
TI  - The Children's Ward as a Special Department.

PMID- 29827142
TI  - Visitors at Surgical Operations.

PMID- 29827141
TI  - The Decision and Discussion of the Liverpool Meeting.

PMID- 29827144
TI  - Legal Notes for Institutional Workers.

PMID- 29827143
TI  - The Nottingham and Midland Eye Infirmary.

PMID- 29827145
TI  - The New Eye Infirmary in Detail and Illustration.

PMID- 29827146
TI  - Hospital and Institutional News.

PMID- 29827147
TI  - The Voluntary Contributor.

PMID- 29827148
TI  - The Editor's Letter-Box.

PMID- 29827149
TI  - The Ward Laboratory.-I.

PMID- 29827150
TI  - Research and Remedies.

PMID- 29827151
TI  - The Utilisation of Isolation Hospitals as Sanatoria.

PMID- 29827152
TI  - Industrial Training and After-Care.

PMID- 29827154
TI  - Departments Which Do Not Always Pay.

PMID- 29827153
TI  - The X-Rays.

PMID- 29827156
TI  - Hospital Construction Competitions.

PMID- 29827155
TI  - Employees and the National Insurance Act: IX. The Contributions Payable.

PMID- 29827157
TI  - The Institutional Worker.

PMID- 29827158
TI  - The Progress of the Tuberculosis Committee.

PMID- 29827159
TI  - Legal Notes for Institutional Workers.

PMID- 29827160
TI  - The Treatment of Sarcoma: The Use of Coley's Fluid in Inoperable Cases.

PMID- 29827161
TI  - Hospital and Institutional News.

PMID- 29827162
TI  - The Insurance Act and Party Politics.

PMID- 29827163
TI  - The Home and Infirmary for Sick Children, Sydenham.

PMID- 29827165
TI  - Employees and the National Insurance Act: XVII. Awakened Interest in Health
      Insurance.

PMID- 29827164
TI  - Hospitals and Paying Pupils: An Absurd Proposal.

PMID- 29827166
TI  - Comfortable Meals in an Institution-Breakfast.

PMID- 29827167
TI  - The Insurance of Nurses: A Hospital Chairman's Suggestion.

PMID- 29827169
TI  - St. John's Brigade Reviewed in Windsor Great Park.

PMID- 29827168
TI  - Summer "Sickness and Diarrhoea.": The Treatment of the Disease in Children.

PMID- 29827170
TI  - The Institutional Use of Alcoholic Liquors.

PMID- 29827171
TI  - Applied Physiology in Practice.

PMID- 29827173
TI  - The Mural Decoration of Hospitals.

PMID- 29827172
TI  - The Children's Ward in Design and Decoration.

PMID- 29827174
TI  - Medical Problems for Public Consumption.

PMID- 29827175
TI  - Chelsea Hospital and Women Workers.

PMID- 29827176
TI  - The Institutional Worker.

PMID- 29827177
TI  - Hospital and Institutional News.

PMID- 29827178
TI  - The Storm on Hospital Sunday.

PMID- 29827180
TI  - The King Edward Memorial Infirmary at Bristol: A Tour of the New Block with Mr.
      W. E. Budgett, Secretary and House Governor.

PMID- 29827179
TI  - Research and Remedies.

PMID- 29827181
TI  - Preventive Methods in Provincial Institutions.

PMID- 29827182
TI  - The Cult of the Sun-Bath.

PMID- 29827183
TI  - An Italian Hospital Experience.

PMID- 29827184
TI  - A Plea for the Private Nursing Home.

PMID- 29827185
TI  - Employees and the National Insurance Act: XXIII. The Insurance of Aliens.

PMID- 29827187
TI  - Hospital Schools for Domestics.

PMID- 29827186
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29827188
TI  - The Dioradin Treatment.

PMID- 29827189
TI  - The Institutional Worker.

PMID- 29827191
TI  - The Dangers of "Comforters."

PMID- 29827190
TI  - The Royal Commission Report.

PMID- 29827192
TI  - The Insurance Act and Poor-Law Infirmaries.

PMID- 29827193
TI  - Hospital and Institutional News.

PMID- 29827195
TI  - Home and Foreign Spas: XI. Bad-Kreuznach.

PMID- 29827194
TI  - Dislocation of Acromio-Clavicular Joint: Two Cases Treated by Fixation with a
      Lane's Bone Plate.

PMID- 29827196
TI  - The Hunger Strike-A Psychological Problem.

PMID- 29827197
TI  - The "Royal" Medical Benevolent Fund.

PMID- 29827198
TI  - Suction-Gas Plant v. Boiler Engine.

PMID- 29827200
TI  - Employees and the National Insurance Act: X. Arrears of Contribution.

PMID- 29827199
TI  - Registration: A Plea for Unity.

PMID- 29827201
TI  - The Institutional Worker.

PMID- 29827202
TI  - Ulster Hospital for Children and Women, Belfast.

PMID- 29827204
TI  - The Examination Rooms, Theatre, and Lavatories.

PMID- 29827203
TI  - The "Normyl Treatment" of Alcoholism.

PMID- 29827205
TI  - Vertigo: Giddiness in Relation to General Medicine.

PMID- 29827207
TI  - The Recent British Geneva Convention Act, 1911.

PMID- 29827206
TI  - The Asylum Workers' Association.

PMID- 29827209
TI  - Hospital and Institutional News.

PMID- 29827208
TI  - The Waste of Clinical Material in Poor-Law Infirmaries.

PMID- 29827210
TI  - The Lighting of Wards.-I.

PMID- 29827211
TI  - Symptoms and Diagnosis.

PMID- 29827213
TI  - Insurance Day by Day.

PMID- 29827212
TI  - Spring Cleaning in Small Institutions.

PMID- 29827214
TI  - My Motor-Cycling Experiences: By a Country Practitioner.

PMID- 29827215
TI  - Hospital Construction Competitions.

PMID- 29827217
TI  - A Medical Inspector on the School Nurse.

PMID- 29827216
TI  - Hospital Dispensers and the Insurance Act.

PMID- 29827218
TI  - The Latest Types of the Ward Window.

PMID- 29827219
TI  - Hospital and Institutional News.

PMID- 29827221
TI  - Complaints: By a Hospital Chairman: III. Some Recurrent Difficulties.

PMID- 29827220
TI  - Dr. Robert Jones and the Mentally Defective.

PMID- 29827223
TI  - The Intelligence of Rickety Children.

PMID- 29827222
TI  - The Institutional Worker.

PMID- 29827224
TI  - Cerebral Haemorrhage.

PMID- 29827225
TI  - A Comparison of Prices Paid by London Hospitals for Their Food Supplies.-II.

PMID- 29827226
TI  - Little Homes as Centres of Influence.

PMID- 29827228
TI  - Angina Pectoris.

PMID- 29827227
TI  - The National Children's Home at Edgworth, Lancashire.

PMID- 29827229
TI  - Employees and the National Insurance Act: VI. Benefits Receivable under the Act.

PMID- 29827231
TI  - The Reform of Club Practice.

PMID- 29827230
TI  - The King's Fund and Lord Rosebery.

PMID- 29827232
TI  - Legal Notes for Institutional Workers.

PMID- 29827233
TI  - The Abertillery School Clinic: Its Buildings, Organisation, and Advantages.

PMID- 29827235
TI  - Cottage Hospitals as Sanatoria.

PMID- 29827234
TI  - The Architecture of Mental Wards.

PMID- 29827236
TI  - The Endless Pleasures of Photomicrography.

PMID- 29827237
TI  - Dispensing Anomalies in Public Institutions: The Need for a Uniform System.

PMID- 29827238
TI  - The Institutional Worker.

PMID- 29827240
TI  - The British Red Cross Society's Duties in Time of Peace.

PMID- 29827239
TI  - The New Cottage Hospital, Axminster.

PMID- 29827242
TI  - Legal Notes for Institutional Workers.

PMID- 29827243
TI  - Research and Remedies.

PMID- 29827241
TI  - Women Pharmacists and Hospital Dispensing.

PMID- 29827245
TI  - Nurses' Diet at Six Shillings a Head.

PMID- 29827244
TI  - The Hospital Mortuary.

PMID- 29827246
TI  - Hospital and Institutional News.

PMID- 29827247
TI  - The Results of Gastric Surgery.

PMID- 29827249
TI  - Employees and the National Insurance Act: XXVI.-Transfers.

PMID- 29827248
TI  - The X-Rays.

PMID- 29827250
TI  - Some Fever Hospitals and Their Work: A Summary of Recent Improvements.

PMID- 29827251
TI  - Death of the Senior Surgeon to St. George's Hospital: A Many-Sided Career.

PMID- 29827252
TI  - Hospital Needs.

PMID- 29827253
TI  - Sanatoria in the Light of the Departmental Report.

PMID- 29827254
TI  - Hospital and Institutional News.

PMID- 29827255
TI  - Mental Hospitals and the Insurance Act.

PMID- 29827256
TI  - Preventive Methods in Provincial Institutions.

PMID- 29827257
TI  - The Defective and Dependent: XII. Relations of Mental-Defectiveness to
      Unemployment, Immorality, and Crime.

PMID- 29827258
TI  - The Importance of the Natural Feeding of Infants.

PMID- 29827259
TI  - The Library.

PMID- 29827260
TI  - Sister Mary (Miss Mary P. Thomson), for Forty Years Lady Superintendent, Royal
      Infirmary, Sunderland.

PMID- 29827261
TI  - Employees and the National Insurance Act: XXV. Existing Funds of Friendly
      Societies.

PMID- 29827262
TI  - The Lessons of the Measles Epidemic.

PMID- 29827263
TI  - Legal Notes for Institutional Workers.

PMID- 29827264
TI  - Without Encumbrance.

PMID- 29827265
TI  - Nurses' Diet at Six Shillings a Head.

PMID- 29827267
TI  - The Skin Department: Its Object, Staffing, and Cost.

PMID- 29827266
TI  - The Seaford Mock-Marriage Case.

PMID- 29827269
TI  - The Institutional Worker.

PMID- 29827268
TI  - Economy of Labour in Hospital Management.

PMID- 29827271
TI  - The Institutional Worker.

PMID- 29827270
TI  - Research and Remedies.

PMID- 29827273
TI  - The New Cottage Hospital, Axminster.

PMID- 29827272
TI  - A Design for Emergency Hospitals in Industrial Districts.

PMID- 29827274
TI  - What a Mother-Expectant Should Know.

PMID- 29827275
TI  - The Laryngoscope in Theory and Practice: Some Hints on Its Manipulation.

PMID- 29827277
TI  - Legal Notes for Institutional Workers.

PMID- 29827276
TI  - The Walrus and the Carpenter.

PMID- 29827279
TI  - The Ipswich Conference.

PMID- 29827278
TI  - Research and Remedies.

PMID- 29827280
TI  - St. George's Hospital and King Edward's Fund.

PMID- 29827281
TI  - Philately as a Hobby for Medical Men.

PMID- 29827282
TI  - The Latest Work of the British Red Cross Society.

PMID- 29827284
TI  - Hospital and Institutional News.

PMID- 29827283
TI  - St. Bartholomew's Hospital and Its Nurses.

PMID- 29827285
TI  - The Practical Possibilities of Cancer Research.

PMID- 29827287
TI  - Teachers, School Desks, and Lateral Curvature.

PMID- 29827286
TI  - Dispensers under the Insurance Act.

PMID- 29827289
TI  - St. George's Hospital and King Edward's Fund.

PMID- 29827288
TI  - Employees and the National Insurance Act: XVI. How to Choose an Approved Society.

PMID- 29827291
TI  - Economy in the Patients' Diet.

PMID- 29827292
TI  - Pain and Medical Research.

PMID- 29827290
TI  - Water Softening for Institutions: The Type and Cost of Various Appliances
      Compared.

PMID- 29827294
TI  - The Financial Report of the King's Fund.

PMID- 29827293
TI  - Economy of Labour in Hospital Management.

PMID- 29827295
TI  - Life and the British Association.

PMID- 29827296
TI  - In Private Practice: Reflections by a Late Assistant.

PMID- 29827297
TI  - In an East Borneo Hospital.-I.

PMID- 29827298
TI  - The Treatment of Enteric Fever.

PMID- 29827300
TI  - The Proper Planning of Store-Rooms.

PMID- 29827299
TI  - The Institutional Worker.

PMID- 29827301
TI  - Employees and the National Insurance Act: XXVII.-Interpretation of the Act.

PMID- 29827302
TI  - Diet and Service in Mental Hospitals: Dr. J. Francis Dixon on an Experiment at
      West Humberstone.

PMID- 29827304
TI  - The Task of Social Hygiene: Havelock Ellis on the Health of Society.

PMID- 29827303
TI  - Hospital and Institutional News.

PMID- 29827305
TI  - Diagnosis and Treatment of Acute Pancreatitis.

PMID- 29827306
TI  - Lord Salisbury and Paying Patients.

PMID- 29827307
TI  - Dr. William Butchart and "The Milne Treatment.": Honour for a Scotch
      Superintendent.

PMID- 29827308
TI  - The Institutional Worker.

PMID- 29827309
TI  - Swiss Hospitals and Their Administration: With Special Reference to the Cantonal
      Hospital of Geneva.

PMID- 29827310
TI  - Tempera Decorations in Hospitals.

PMID- 29827311
TI  - The Conduct of Competitions: A Suggestion.

PMID- 29827313
TI  - A Hospital Villa for Bexley Mental Hospital.

PMID- 29827312
TI  - Medicine and the Empire.

PMID- 29827314
TI  - Tredegar House, Bow: The London Hospital's New Preliminary Training School.

PMID- 29827315
TI  - The Scientific Treatment of Sea-Sickness.

PMID- 29827316
TI  - Legal Notes for Institutional Workers.

PMID- 29827318
TI  - The Control of the Feeble-Minded.

PMID- 29827317
TI  - Employees and the National Insurance Act: XX. How Rates of Remuneration Affect
      Contributions.

PMID- 29827319
TI  - A Hospital for Poor Mothers.

PMID- 29827320
TI  - Hospital and Institutional News.

PMID- 29827321
TI  - Convalescent Diet.

PMID- 29827322
TI  - Some Fever Hospitals and Their Work: II. Preventive Methods in Provincial
      Institutions.

PMID- 29827324
TI  - Employees and the National Insurance Act: XIX. Insurance Cards and Books.

PMID- 29827323
TI  - Scoliosis and the Crawl Treatment.

PMID- 29827325
TI  - Industrial Colonies for Mental Defectives.

PMID- 29827326
TI  - The Popularity of "The Services."

PMID- 29827327
TI  - Research and Remedies.

PMID- 29827328
TI  - Comfortable Meals in an Institution-Dinner.

PMID- 29827329
TI  - Hospital and Institutional News.

PMID- 29827330
TI  - Some Sanatorium Topics.

PMID- 29827331
TI  - The Institutional Worker.

PMID- 29827333
TI  - The Orthopaedics of the Future: A New Book by Professor Spitzy.

PMID- 29827332
TI  - Some Fever Hospitals and Their Work: I. Cross-Infection in Special Wards.

PMID- 29827334
TI  - The Clearing Hospitals for the Territorial Medical Service.

PMID- 29827335
TI  - The Chancellor of the Exchequer's Lack of Statesmanship.

PMID- 29827336
TI  - The Planning of the Modern Operating Theatre Unit.

PMID- 29827337
TI  - Economy of Labour in Hospital Management.

PMID- 29827338
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29827339
TI  - Oxford University.

PMID- 29827340
TI  - The Royal Naval Medical Service: What It Offers to the Newly Qualified Medical
      Man.

PMID- 29827341
TI  - The Study of Tropical Medicine.

PMID- 29827342
TI  - Higher Diplomas.

PMID- 29827343
TI  - The London University Course.

PMID- 29827344
TI  - Women Resident Doctors in Poor-Law Infirmaries.

PMID- 29827345
TI  - The School Service: What It Offers to the Newly Qualified.

PMID- 29827347
TI  - The Public Services.

PMID- 29827346
TI  - Doctors' Fees and Nursing Homes.

PMID- 29827348
TI  - Obstetrics and Gynaecology: The Education and Training of the Specialist.

PMID- 29827350
TI  - The Institutional Worker.

PMID- 29827349
TI  - Tea at the Hall: Some Recollections of a Far-Distant Final.

PMID- 29827351
TI  - Qualification and Registration.

PMID- 29827352
TI  - Opportunities for Graduate Study in Special Hospitals.

PMID- 29827354
TI  - The English Conjoint Course.

PMID- 29827353
TI  - Hospital and Institutional News.

PMID- 29827355
TI  - The Remuneration of the Institutional Dispenser.

PMID- 29827356
TI  - Mental Work as a Young Man's Career: The Life and Progress of the Assistant
      Medical Officer.

PMID- 29827357
TI  - London Post-Graduate Institutions.

PMID- 29827358
TI  - The Medical Student and His Work: The Medical Schools of the United Kingdom.

PMID- 29827359
TI  - The Choice of Medicine.

PMID- 29827360
TI  - Resident Medical Officership in the Future: The Advantages and Disadvantages of
      Such a Career.

PMID- 29827361
TI  - The Cambridge University Course.

PMID- 29827362
TI  - Doctors' Fees and Nursing Homes.

PMID- 29827363
TI  - The Royal Army Medical Corps: Admission, Pay, Prospects, and Terms of Retirement.

PMID- 29827364
TI  - The West Ham Hospital's Jubilee.

PMID- 29827365
TI  - St. George's Hospital and King Edward's Fund.

PMID- 29827366
TI  - Employees and the National Insurance Act: XII. The Insurance of Hospital Nurses.

PMID- 29827367
TI  - The Diphtheria Bacillus and Its Media.

PMID- 29827368
TI  - Departments Which Do Not Always Pay.

PMID- 29827369
TI  - No. 1 Wimpole Street: The New Premises of the Royal Society of Medicine.

PMID- 29827370
TI  - The Disconnection of Sanitary Towers.

PMID- 29827372
TI  - A Sixty-Hour Week for Mental Hospital Workers.

PMID- 29827371
TI  - The "Normyl Treatment" of Alcoholism.

PMID- 29827374
TI  - Vaccine Therapy and Sanatoria: The Inoculation Department of St. Mary's Hospital.

PMID- 29827373
TI  - The X-Rays.

PMID- 29827376
TI  - The Institutional Worker.

PMID- 29827375
TI  - The Asylum Workers' Association.

PMID- 29827378
TI  - Hospital and Institutional News.

PMID- 29827377
TI  - The Plans of the Sheffield Royal Hospital.

PMID- 29827379
TI  - The Feeble-Minded in Poor-Law Infirmaries.

PMID- 29827380
TI  - Its Time-Table, Attendance, and Staff-III.

PMID- 29827381
TI  - Research and Remedies.

PMID- 29827382
TI  - Diseases of the Larynx: The Cardinal Symptoms of Throat Disease.

PMID- 29827383
TI  - New Remedies and Old Diseases.

PMID- 29827384
TI  - The Training and Work of a Hospital Almoner.

PMID- 29827385
TI  - Employees and the National Insurance Act: XI. The Insurance of Nurses.

PMID- 29827387
TI  - Hospital Dispensers and the Insurance Act.

PMID- 29827386
TI  - Some Reflections on Boarding School Diet.

PMID- 29827389
TI  - Hospital and Institutional News.

PMID- 29827388
TI  - Legal Notes for Institutional Workers.

PMID- 29827390
TI  - Midland Hospitals and the Insurance Act.

PMID- 29827391
TI  - Economy in Baked Meats.

PMID- 29827393
TI  - The Resident Medical Officer of the Future.

PMID- 29827392
TI  - The Charges against Hinckley Isolation Hospital.

PMID- 29827395
TI  - The Lighting of Wards.-II.

PMID- 29827394
TI  - Institutional Laundries.

PMID- 29827396
TI  - The Ward Laboratory.-II.

PMID- 29827397
TI  - Letters from the Honorary Secretaries of King's Fund and the Treasurer of St.
      George's.

PMID- 29827399
TI  - The Progress of the Sanatorium Idea.

PMID- 29827398
TI  - The Institutional Worker.

PMID- 29827400
TI  - The Provision of Sanatoria.

PMID- 29827401
TI  - The Institutional Worker.

PMID- 29827403
TI  - Lateral Curvature and the Clinic.

PMID- 29827402
TI  - Legal Notes for Institutional Workers.

PMID- 29827404
TI  - The X-Rays.

PMID- 29827405
TI  - A Private Visit to the Hamadryad Seamen's Hospital.

PMID- 29827406
TI  - King Edward VII.'s Hospital, Cardiff, Begins a New Era.

PMID- 29827407
TI  - The British Hospitals Association Meeting.

PMID- 29827408
TI  - The Cavendish Lecture.

PMID- 29827409
TI  - Employees and the National Insurance Act: XVIII. Important Points for Immediate
      Consideration.

PMID- 29827410
TI  - The Editor's Letter-Box.

PMID- 29827411
TI  - Housekeeping Queries.

PMID- 29827412
TI  - A Sixteenth-Century Complaint.

PMID- 29827413
TI  - The London Dermatological Society.

PMID- 29827415
TI  - Hospital and Institutional News.

PMID- 29827414
TI  - A Midland Hospital and the Commissioners.

PMID- 29827416
TI  - Dr. Albert Moll and a Neglected Aspect of Pedagogy.

PMID- 29827417
TI  - Reports on the Hospitals of the United Kingdom.

PMID- 29827418
TI  - Research Laboratories for Mental Hospitals.

PMID- 29827419
TI  - Petrox.

PMID- 29827420
TI  - The Institutional Worker.

PMID- 29827421
TI  - A Good Method of Cooking Frozen Meat.

PMID- 29827422
TI  - The Mental Hospital Kitchen.

PMID- 29827423
TI  - Its Architecture, Planning, and Control.

PMID- 29827424
TI  - Cerebral Haemorrhage.-III.

PMID- 29827425
TI  - Russo's Methylene Blue Reaction.

PMID- 29827426
TI  - Hospital Construction Competitions.

PMID- 29827427
TI  - Employees and the National Insurance Act: VIII. The Contributions Payable.

PMID- 29827428
TI  - Hospital and Institutional News.

PMID- 29827430
TI  - King Edward's Hospital Fund for London.

PMID- 29827429
TI  - Suction-Gas Plant v. Boiler Engine.

PMID- 29827432
TI  - Up-To-Date Kitchen Specialties.

PMID- 29827431
TI  - John Marshall, Chairman of the Royal Infirmary, Sheffield.

PMID- 29827433
TI  - Notes in Reply to Mr. Hall's Strictures on the Criticisms of F.R.I.B.A. "Nos. 1
      and 2."

PMID- 29827434
TI  - The Kitchen Equipment for a Large Hospital.

PMID- 29827436
TI  - Research and Remedies.

PMID- 29827435
TI  - Institutional Laundries.

PMID- 29827437
TI  - The National Health Week.

PMID- 29827438
TI  - Some Continental Hospitals: The Rudolf Virchow and Beelitz-i-Mark Kitchens.

PMID- 29827439
TI  - The Inspection of Meat: The Present System and Where It Needs Reform.

PMID- 29827441
TI  - The Institutional Worker.

PMID- 29827440
TI  - Our Work Here and Hereafter.

PMID- 29827443
TI  - London's Institutional Medical Relief: Proposals for Its Reform.

PMID- 29827442
TI  - A Remarkable Organisation.

PMID- 29827444
TI  - On the Fringe of the Empire.

PMID- 29827445
TI  - Food in War-Time.

PMID- 29827446
TI  - The Territorial Medical Officers.

PMID- 29827447
TI  - Institutional Needs.

PMID- 29827448
TI  - Round the Hospitals.

PMID- 29827449
TI  - National Necessities and Sacrifices.

PMID- 29827450
TI  - Hospital and Institutional News.

PMID- 29827451
TI  - King Edward VII.'s Hospital, Cardiff.

PMID- 29827452
TI  - Lord Lister: XII. His Triumph, Complete and Universal.

PMID- 29827453
TI  - Memorial Service for Nurses Who Have Fallen in the War.

PMID- 29827454
TI  - Phrases and Realities.

PMID- 29827455
TI  - The Absence of Esprit De Corps.

PMID- 29827457
TI  - Round the Hospitals.

PMID- 29827456
TI  - Nursing Progress and Its Developments: XII. The Local Aims of Local Centres.

PMID- 29827458
TI  - The Growth of the Nursing Profession: VI. Opportunities of Study for the Graduate
      Nurse.

PMID- 29827459
TI  - Lord Lister: XI. London's Indifference to Listerism.

PMID- 29827460
TI  - Hospital and Institutional News.

PMID- 29827461
TI  - The Crucifixion of Love.

PMID- 29827462
TI  - Propaganda: The Effort Towards Union.

PMID- 29827463
TI  - The Abuse of Salt and Vinegar.

PMID- 29827465
TI  - Parliament and the Profession.

PMID- 29827464
TI  - Fitness for Military Service.

PMID- 29827466
TI  - Reports of Scottish Asylums.

PMID- 29827467
TI  - The Great War: V. Sickness.

PMID- 29827468
TI  - The Pioneers of America's United Effort.

PMID- 29827469
TI  - Beckett Hospital, Barnsley.

PMID- 29827470
TI  - Some Annual Meetings.

PMID- 29827472
TI  - The Silence of the Nurse: One Suggested Reason.

PMID- 29827471
TI  - The Institutional Worker.

PMID- 29827473
TI  - Round the Hospitals.

PMID- 29827474
TI  - Social Service at St. Thomas's Hospital.

PMID- 29827475
TI  - Matrons and Nurses Who Prefer the "London" Training.

PMID- 29827476
TI  - Sir George Newman Performs a Miracle.

PMID- 29827477
TI  - The Minister of Pensions and Poor-Law Infirmary Accommodation.

PMID- 29827478
TI  - London's Hospital Sunday Yields L85,000.

PMID- 29827479
TI  - The Institutional Worker.

PMID- 29827480
TI  - Her Health, Common Dangers and Salvation.

PMID- 29827482
TI  - Hospital and Institutional News.

PMID- 29827481
TI  - Medicine in America.

PMID- 29827483
TI  - "Ierne's" Prodding Processes.

PMID- 29827484
TI  - Its Incidence during Recent Years.

PMID- 29827486
TI  - How to Organise Both.

PMID- 29827485
TI  - Who Fears to Speak?

PMID- 29827488
TI  - The Cry for Freedom.

PMID- 29827487
TI  - The Woman Worker's World.

PMID- 29827489
TI  - Maternity and Child Welfare.

PMID- 29827490
TI  - Nursing Progress and Its Developments: The Local Executive Committee.

PMID- 29827491
TI  - Australian Notes.

PMID- 29827492
TI  - A Boycotted Hospital.

PMID- 29827493
TI  - Round the Hospitals.

PMID- 29827494
TI  - Hospital and Institutional News.

PMID- 29827495
TI  - The Origin of the Act of 1890.

PMID- 29827496
TI  - A Summary of the L.G.B. Circular.

PMID- 29827497
TI  - Arterio-Sclerosis and Blood Pressure.

PMID- 29827498
TI  - The Institutional Worker.

PMID- 29827499
TI  - Some Medical Aspects of Malingering.

PMID- 29827500
TI  - The Institutional Worker.

PMID- 29827502
TI  - Training-Schools and Public Health Work.

PMID- 29827501
TI  - Hospital and Institutional News.

PMID- 29827503
TI  - The "Effort Syndrome" in Relation to Blood Quality.

PMID- 29827504
TI  - A Display in Domestic Economy.

PMID- 29827506
TI  - The Men of Fifty.

PMID- 29827505
TI  - Parliament and the Profession.

PMID- 29827507
TI  - "Ierne" and Nurses All.

PMID- 29827508
TI  - National Baby Week.

PMID- 29827510
TI  - United and Joyous.

PMID- 29827509
TI  - Round the Hospitals.

PMID- 29827512
TI  - Census of Limbless Civilians in Wales.

PMID- 29827511
TI  - The Training of an Asylum Matron.

PMID- 29827513
TI  - A Village Committee.

PMID- 29827514
TI  - As Made at the Pavilion General Hospital, Brighton.

PMID- 29827515
TI  - The Public Health.

PMID- 29827516
TI  - Infirmary Medical Superintendents' Recommendations.

PMID- 29827517
TI  - The Institutional Worker.

PMID- 29827518
TI  - The Fate of the Agitator.

PMID- 29827519
TI  - The Medical Professions after the War.

PMID- 29827520
TI  - The Awakening of the People.

PMID- 29827521
TI  - The Pension Minister at Leicester.

PMID- 29827522
TI  - Parliament and the Profession.

PMID- 29827523
TI  - The Emotional Temperament.

PMID- 29827524
TI  - Leicester Health Advisory Committee.

PMID- 29827526
TI  - Why Did America Declare War?

PMID- 29827525
TI  - The Woman Worker's World.

PMID- 29827528
TI  - Silver Wedding Portrait of Their Majesties.

PMID- 29827527
TI  - Round the Hospitals.

PMID- 29827529
TI  - The Nineteenth and Twentieth Centuries.

PMID- 29827530
TI  - Not a Gorgon Sister.

PMID- 29827531
TI  - Place Aux Enfants.

PMID- 29827532
TI  - Hospital and Institutional News.

PMID- 29827533
TI  - Some Experiences of Training School Life: III. Are the Hardening Influences
      Remedial?

PMID- 29827535
TI  - A Nurses' Charter of Liberty.

PMID- 29827534
TI  - Academic Distinction in Medicine.

PMID- 29827536
TI  - Horrors and Abuses of the Old Madhouses.

PMID- 29827537
TI  - Westminster and King's College Hospitals.

PMID- 29827539
TI  - Round the Hospitals.

PMID- 29827538
TI  - The "Women's Ambulance" in a Shell Factory.

PMID- 29827540
TI  - The Institutional Worker.

PMID- 29827542
TI  - The State and the Malingerer.

PMID- 29827541
TI  - The Insurance Act and Its Administrators.

PMID- 29827543
TI  - The B.M.A. Representative Meeting.

PMID- 29827544
TI  - The Constitution of the Local Centre.

PMID- 29827545
TI  - State Aid for the Working Man's Child.

PMID- 29827546
TI  - Hospital and Institutional News.

PMID- 29827548
TI  - British Science during the War.

PMID- 29827547
TI  - London Hospital Nurses: Miss Lynette Gould's View; Miss McKinley Withdraws Her
      Statements.

PMID- 29827549
TI  - The Editor's Letter-Box.

PMID- 29827550
TI  - Guest Hospital, Dudley.

PMID- 29827551
TI  - The Public Health.

PMID- 29827552
TI  - Unfavourable Breeding Ground for Malaria.

PMID- 29827553
TI  - Overdone Advocacy v. Common Sense.

PMID- 29827555
TI  - Institutional Needs.

PMID- 29827554
TI  - The South African Military Nursing Service.

PMID- 29827556
TI  - The Louse: Its Habits and Methods.

PMID- 29827557
TI  - Panel Doctors and Insurance Committees.

PMID- 29827558
TI  - Orthopaedics "Napoo" at Leicester.

PMID- 29827559
TI  - Hospital and Institutional News.

PMID- 29827560
TI  - The Control of V.A.D. Hospitals.

PMID- 29827561
TI  - Sir Henry Morris' Decision.

PMID- 29827562
TI  - Passing Topics and Movements.

PMID- 29827563
TI  - Parliament and the Profession.

PMID- 29827566
TI  - Independence or Contumacy?

PMID- 29827565
TI  - Round the Hospitals.

PMID- 29827564
TI  - Much Educational Matter Addressed to the Public.

PMID- 29827567
TI  - Inter-Allied Scientific Food Commission.

PMID- 29827568
TI  - Sir Arthur Stanley's Visit. Who Has Been "Done"?

PMID- 29827569
TI  - The Institutional Worker.

PMID- 29827570
TI  - District Nursing: III. The Labourer and Her Hire.

PMID- 29827571
TI  - A Case of Huntington's Chorea: Sir Clifford Allbutt's Clinical Lecture.

PMID- 29827573
TI  - War Bread.

PMID- 29827572
TI  - Ireland's Prosperity Unexampled: Ireland for the Irish-With British Millions for
      Irish Cultivators!

PMID- 29827574
TI  - Housekeepers, Cooks, and the Death-Rate.

PMID- 29827575
TI  - The Institutional Worker.

PMID- 29827577
TI  - Round the Hospitals.

PMID- 29827576
TI  - Some Problems of To-Day: The Unmarried Mother.

PMID- 29827578
TI  - Annual Meetings.

PMID- 29827579
TI  - The Employment of the Waiting Years.

PMID- 29827580
TI  - English Mission Hospital, Baghdad.

PMID- 29827581
TI  - The Question of Population.

PMID- 29827583
TI  - The Future of the Medical Profession.

PMID- 29827582
TI  - An Imperial Union of Nurses.

PMID- 29827585
TI  - Hospital and Institutional News.

PMID- 29827584
TI  - Deaths in Cottage Hospitals.

PMID- 29827586
TI  - The Growth of the Nursing Profession: VIII. The Deeper and Wider Wants of the
      Nurse.

PMID- 29827587
TI  - Parliament and the Profession.

PMID- 29827588
TI  - Nurses' Tribute Fund.

PMID- 29827589
TI  - Hospital and Institutional News.

PMID- 29827591
TI  - The Doings of St. Dunstan's Men.

PMID- 29827590
TI  - Nursing Progress and Its Developments: XIII. The Local Centre System for London.

PMID- 29827592
TI  - Defects in the Lunacy Law: Some Changes Held to Be Desirable.

PMID- 29827593
TI  - A New Disease or Food Poisoning?: The Position Defined and the Public Directed.

PMID- 29827594
TI  - Round the Hospitals.

PMID- 29827596
TI  - Parliament and the Profession.

PMID- 29827595
TI  - The Shortage of Domestic Help.

PMID- 29827597
TI  - The Organisation of British Ophthalmologists: A Representative Council Formed.

PMID- 29827598
TI  - Report of the Prime Minister's Committee: I. Subjects to be Taught.

PMID- 29827600
TI  - The Institutional Worker.

PMID- 29827599
TI  - Tea Not a Food but by Order.

PMID- 29827601
TI  - Civil Hospitals and the Care of Military Patients: Some United States' Problems.

PMID- 29827602
TI  - Round the Hospitals.

PMID- 29827603
TI  - The Cultivation of Legacies: Help the Lawyers to Help the Hospitals.

PMID- 29827604
TI  - Some Problems of To-Day.

PMID- 29827606
TI  - Report of the Prime Minister's Committee: III. Abolish Present Waste of Intellect
      and Provide Better System.

PMID- 29827605
TI  - The Case against the Comforts Depot.

PMID- 29827607
TI  - A Nurse's Charter of Liberty.

PMID- 29827608
TI  - Which Is the Oldest Hospital?

PMID- 29827609
TI  - Parliament and the Profession.

PMID- 29827610
TI  - Changes in the System of Nurse Training at the London Hospital.

PMID- 29827611
TI  - The Growth of the Nursing Profession: IX. Some War Thoughts and a New Spirit.

PMID- 29827612
TI  - A Challenge to the Colleges.

PMID- 29827614
TI  - Fewer Suicides: Due to Less Drinking and Increased Employment.

PMID- 29827613
TI  - With the Red Cross in Palestine.

PMID- 29827615
TI  - Hospital and Institutional News.

PMID- 29827616
TI  - The Scheme of the British Medical Association.-II.

PMID- 29827617
TI  - The Great War: VIII. Sanitation.

PMID- 29827618
TI  - Drawing-Room Meeting in Edinburgh.

PMID- 29827619
TI  - The Institutional Worker.

PMID- 29827620
TI  - King Edward's Hospital Fund for London: Its Majority. Some Wonderful Results.

PMID- 29827621
TI  - Parliament and the Profession.

PMID- 29827623
TI  - Annual Meeting of the Governors and General Council.

PMID- 29827622
TI  - Democratic and Non-Democratic Elections.

PMID- 29827625
TI  - An Open Letter from "Ierne": To the Hon. Sir Arthur Stanley, G.B.E., M.P.,
      Chairman of the College of Nursing.

PMID- 29827624
TI  - Bird Migration Seen South of Gaza.

PMID- 29827627
TI  - Round the Hospitals.

PMID- 29827626
TI  - Medical Fees to Fellow Practitioners.

PMID- 29827629
TI  - New Zealand Nursing Service.

PMID- 29827628
TI  - Report of the Prime Minister's Committee: II: The Choice of a Profession:
      English, Natural Science, and Mathematics.

PMID- 29827631
TI  - The Treatment of Neurasthenics.

PMID- 29827630
TI  - The Scheme of the British Medical Association.

PMID- 29827632
TI  - Hospital and Institutional News.

PMID- 29827633
TI  - A Section of the Future Imperial War Museum.

PMID- 29827634
TI  - The Re-Education of the Defective.

PMID- 29827635
TI  - The Institutional Worker.

PMID- 29827636
TI  - Annual Meetings of Four Children's Hospitals.

PMID- 29827637
TI  - The Hon. Sir Arthur Stanley's Reply to "Ierne's" Open Letter.

PMID- 29827639
TI  - Devil's Work.

PMID- 29827638
TI  - The London and Counties Medical Protection Society, Limited.

PMID- 29827640
TI  - A National Tribute Fund.

PMID- 29827641
TI  - Round the Hospitals.

PMID- 29827642
TI  - The College of Nursing.

PMID- 29827643
TI  - The Public Spirit of Property Owners.

PMID- 29827644
TI  - The College Conferences and Subsequent Gains.

PMID- 29827645
TI  - Hospital and Institutional News.

PMID- 29827646
TI  - The Institutional Care of the Insane in the United States and Canada.

PMID- 29827647
TI  - Cost of Military Patients in Civil Hospitals: The Inquiry upon Which the Present
      Grant Was Based.

PMID- 29827648
TI  - Round the Hospitals.

PMID- 29827649
TI  - Some Experiences of Training-School Life: II. Some Hardening Influences in
      Training.

PMID- 29827650
TI  - Medical Reform and the Individual Patient.

PMID- 29827651
TI  - A Hospital Meeting at Downing Street.

PMID- 29827652
TI  - Parliament and the Profession.

PMID- 29827653
TI  - London Hospital Nurses.

PMID- 29827654
TI  - Sophia Jex-Blake: A Great Personality: She Opened the Medical Profession to
      Women.

PMID- 29827655
TI  - We Call Our Colonel 'Charlie,' and We Obey Orders.

PMID- 29827656
TI  - The Greatest Hardship of the Assistant Medical Officer.

PMID- 29827658
TI  - A Medical Witness on Medical Ethics and Things in General.

PMID- 29827657
TI  - Children's Country Holidays Fund.

PMID- 29827659
TI  - More Rescue Stations Urgently Required.

PMID- 29827660
TI  - From Major Chapple, M.P., R.A.M.C.

PMID- 29827661
TI  - From Viscount Knutsford.

PMID- 29827662
TI  - From Samaritan Fund to Social Service Department.

PMID- 29827663
TI  - Hospital and Institutional News.

PMID- 29827665
TI  - Promotion in the R.A.M.C.

PMID- 29827664
TI  - Meeting in Leeds: Local Centre to Be Formed.

PMID- 29827667
TI  - The Great War: VI. The Progress of the Sick (concluded).

PMID- 29827666
TI  - Botulism: Its Nature, Symptoms and Treatment.

PMID- 29827669
TI  - The Employment of the Waiting Years.

PMID- 29827668
TI  - The Problem of Advanced Consumption.

PMID- 29827670
TI  - The Great War: VII. Sanitation.

PMID- 29827672
TI  - Round the Hospitals.

PMID- 29827671
TI  - The Shortage of Domestic Help: Work of National Importance.

PMID- 29827673
TI  - H M. Queen Mary, British Mothers, and Their Warrior Sons.

PMID- 29827674
TI  - Rations for Hospitals.

PMID- 29827675
TI  - The Australian Nursing Service in the War.

PMID- 29827676
TI  - The Making of a Trained Nurse: Possible Changes Due to the War.

PMID- 29827677
TI  - Hospital and Institutional News.

PMID- 29827678
TI  - The Economics of Nursing.

PMID- 29827680
TI  - War-Time Work in an Infirmary.

PMID- 29827679
TI  - Meeting in Manchester.

PMID- 29827681
TI  - The Worthy Person.

PMID- 29827682
TI  - The Site of St. Mark's Hospital.

PMID- 29827683
TI  - The Institutional Worker.

PMID- 29827684
TI  - The New Clinic at Liverpool Royal Infirmary.

PMID- 29827685
TI  - Institutional Medical Relief in London.

PMID- 29827686
TI  - London Baby Week: Some Lessons of the Conference.

PMID- 29827687
TI  - Parliament and the Profession.

PMID- 29827688
TI  - By What Process Would Registration Contribute to the Prosperity of the British
      Nurse?

PMID- 29827689
TI  - The College of Nursing in Scotland.

PMID- 29827690
TI  - The Great War: X. Personal Cleanliness: Vermin.

PMID- 29827691
TI  - Nurse Registration in America.

PMID- 29827692
TI  - As Made at the Pavilion General Hospital, Brighton: II. Above-the-Knee Legs.

PMID- 29827693
TI  - Round the Hospitals.

PMID- 29827694
TI  - News from Australia.

PMID- 29827695
TI  - King George and Queen Mary.

PMID- 29827696
TI  - Funds of the Past, Present, and Future.

PMID- 29827697
TI  - Hospital and Institutional News.

PMID- 29827699
TI  - Questions in Parliament.

PMID- 29827698
TI  - Viscount Knutsford's Reply in the Times.

PMID- 29827700
TI  - The "Llandovery Castle" Outrage: Survivor's Story to the King.

PMID- 29827701
TI  - Industrial Accidents in War-Time.

PMID- 29827703
TI  - Hospital and Institutional News.

PMID- 29827702
TI  - Its Relation to Applicants for Training.

PMID- 29827705
TI  - Mother and Child in Scotland.

PMID- 29827704
TI  - Food Rationing and National Efficiency.

PMID- 29827706
TI  - The Institutional Worker.

PMID- 29827707
TI  - Nervous and Mental Disorders.

PMID- 29827708
TI  - A Case of Strangulated Femoral Hernia.

PMID- 29827709
TI  - Round the Hospitals.

PMID- 29827710
TI  - Shylock's Argument out of Court.

PMID- 29827711
TI  - Nursing Progress and Its Developments: A Year's Work at the College of Nursing.

PMID- 29827712
TI  - Village Practice.-III: An Autobiographical Fragment.

PMID- 29827713
TI  - A Public Medical Service in Being: Leicester's Useful Example.

PMID- 29827714
TI  - The Effects of Colour on Individuals.

PMID- 29827715
TI  - What Nurses Should Seek and Find.

PMID- 29827716
TI  - The Growth of the Nursing Profession: VII. The Employment of the Waiting Years.

PMID- 29827717
TI  - Pernicious Propaganda.

PMID- 29827718
TI  - New President of Royal College of Physicians.

PMID- 29827719
TI  - A Volume to Be Read and Studied.

PMID- 29827721
TI  - The New Man-Power Scheme.

PMID- 29827720
TI  - Hospital Life in Macedonia.

PMID- 29827722
TI  - Hahnemann and Public Confidence.

PMID- 29827723
TI  - Germans and Others behind the Age.

PMID- 29827724
TI  - The Great War: VI. The Progress of the Sick.

PMID- 29827725
TI  - The Institutional Worker.

PMID- 29827726
TI  - The Valley of Ajalon.

PMID- 29827727
TI  - Medicine and Politics.

PMID- 29827728
TI  - Important Letter from the Chairman, with the Report of the Medical Board.

PMID- 29827729
TI  - Hospital Finance in 1917.

PMID- 29827730
TI  - Round the Hospitals.

PMID- 29827731
TI  - Some Annual Meetings.

PMID- 29827732
TI  - Hospital and Institutional News.

PMID- 29827733
TI  - Parliament and the Profession.

PMID- 29827734
TI  - H.M. King George at Lincoln.

PMID- 29827735
TI  - The London Hospital.

PMID- 29827736
TI  - Domestic Service in Military Hospitals.

PMID- 29827738
TI  - The Second Inter-Allied Conference.

PMID- 29827737
TI  - British Home and Hospital for Incurables, Streatham.

PMID- 29827739
TI  - The Trained Nurse the Nation's Creditor.

PMID- 29827740
TI  - The Economic Relations of Functional Nervous Diseases.

PMID- 29827741
TI  - National Medical Union.

PMID- 29827742
TI  - District Nursing: I. A Historical Sketch.

PMID- 29827743
TI  - The Great War: IX. Flies and Disease.

PMID- 29827744
TI  - Irish Nursing Affairs.

PMID- 29827745
TI  - Round the Hospitals.

PMID- 29827746
TI  - A Nurse's Charter of Liberty: Viscount Knutsford's Reply to "Ierne."

PMID- 29827747
TI  - Higher Salaries for Mental Nurses.

PMID- 29827748
TI  - The General Medical Council's Problems.

PMID- 29827749
TI  - Hospital and Institutional News.

PMID- 29827750
TI  - The Shy Person.

PMID- 29827752
TI  - An Indian Civil Medical Service.

PMID- 29827751
TI  - H.M. Queen Alexandra's Letter.

PMID- 29827753
TI  - The Notification of Ophthalmia Neonatorum in Scotland.

PMID- 29827754
TI  - The Sole Test of Sanity.

PMID- 29827755
TI  - The Problem of the Discharged Soldier.

PMID- 29827756
TI  - Sir Guy Calthrop's Appeal to the Medical Profession.

PMID- 29827757
TI  - The Power of the College of Nursing.

PMID- 29827759
TI  - Doctors and Lodges: The Commission's Finding.

PMID- 29827758
TI  - Antique Hunting and Its Philosophy.

PMID- 29827760
TI  - Nursing Progress and Its Developments: The Local Finance Committee.

PMID- 29827761
TI  - Hospital and Institutional News.

PMID- 29827762
TI  - Round the Hospitals.

PMID- 29827763
TI  - Matrons, and Nurse Agitators.

PMID- 29827765
TI  - The Nomenclature of Diseases.

PMID- 29827764
TI  - The Sacrifice of the Civilian.

PMID- 29827766
TI  - The Institutional Worker.

PMID- 29827767
TI  - Higher Diplomas.

PMID- 29827768
TI  - Specialism and Graduate Work.

PMID- 29827769
TI  - Dentistry as a Profession: Its Drawbacks and Preparations to Qualify.

PMID- 29827771
TI  - The Future of Medicine.

PMID- 29827770
TI  - The Public Health Services.

PMID- 29827773
TI  - London University Course.

PMID- 29827772
TI  - Cambridge University Course.

PMID- 29827774
TI  - The Public Services.

PMID- 29827775
TI  - Graduate Study in London Special Hospitals.

PMID- 29827776
TI  - The Subjective Influence of the Study of Medicine.

PMID- 29827777
TI  - Hopes for Modifications That Are Yet to Come.

PMID- 29827779
TI  - Present Conditions and Prospects.

PMID- 29827778
TI  - Graduate Institutions in London.

PMID- 29827780
TI  - The English Conjoint Course.

PMID- 29827781
TI  - Medical Education in War-Time.

PMID- 29827782
TI  - Oxford University Course.

PMID- 29827783
TI  - The Medical Schools of the United Kingdom.

PMID- 29827784
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29827785
TI  - The Royal Naval Medical Service.

PMID- 29827786
TI  - Education and Other Matters.

PMID- 29827787
TI  - Qualification and Registration.

PMID- 29827788
TI  - Tropical Medicine.

PMID- 29827789
TI  - Parliament and the Profession.

PMID- 29827790
TI  - Australian Troops' Bravery.

PMID- 29827791
TI  - Hospital and Institutional News.

PMID- 29827792
TI  - The Woman Workers' World.

PMID- 29827793
TI  - From Sir Henry Burdett, K.C.B.

PMID- 29827794
TI  - Letter from Sir Henry Burdett, K.C.B.

PMID- 29827795
TI  - From Viscount Knutsford.

PMID- 29827796
TI  - Value of First Aid in the Management of Mental Cases and Hospitals.-Part II.

PMID- 29827797
TI  - The British Pharmaceutical Conference.

PMID- 29827798
TI  - The Call to Strengthen the Nursing Profession.

PMID- 29827800
TI  - The Making of Profit and the British Nurse: The Argument and the Moral.

PMID- 29827799
TI  - The Ministry of Health.

PMID- 29827801
TI  - Round the Hospitals.

PMID- 29827802
TI  - As Made at the Pavilion General Hospital, Brighton: IV. Details of Organisation.

PMID- 29827804
TI  - The Royal Sanitary Institute.

PMID- 29827803
TI  - The Great War: XI. Personal Cleanliness: II. Vermin.

PMID- 29827806
TI  - Medical Women in the Army.

PMID- 29827805
TI  - Progressive Developments from 1090 Onwards.

PMID- 29827807
TI  - The Institutional Worker.

PMID- 29827808
TI  - Interesting Points from Half-Yearly Meeting.

PMID- 29827809
TI  - Institutional Needs.

PMID- 29827810
TI  - Round the Hospitals.

PMID- 29827812
TI  - Changes at the Pharmaceutical Society.

PMID- 29827811
TI  - Lord Knutsford's Reply to "Ierne's" Shylock's Article.

PMID- 29827813
TI  - The Annual Reminder of Hospital Sunday.

PMID- 29827814
TI  - District Nursing: II. Some Aspects of the Work.

PMID- 29827815
TI  - The Great War: IX. Flies and Disease (concluded).

PMID- 29827816
TI  - A Single Year's Roll-Call of the Sick.

PMID- 29827818
TI  - Hospital Appeals.

PMID- 29827817
TI  - Designed by Hogarth.

PMID- 29827819
TI  - Hospitals and Their Special Needs.

PMID- 29827820
TI  - The Voluntary Hospitals' Budget.

PMID- 29827821
TI  - The Claims of Qualified Dentistry.

PMID- 29827822
TI  - The Annual Meeting.

PMID- 29827824
TI  - Dr. Mercier and Asylum Workers: A Mansion House Speech and Some Reminiscences.

PMID- 29827823
TI  - The Institutional Worker.

PMID- 29827825
TI  - The Hon. Sir Arthur Stanley's Visit.

PMID- 29827827
TI  - Hospital and Institutional News.

PMID- 29827826
TI  - 1917. A Year's Work in the Hospitals and Medical Charities of London.

PMID- 29827828
TI  - Parliament and the Profession.

PMID- 29827829
TI  - The Churches and the War: Hospital Sunday.

PMID- 29827830
TI  - Some Foreign Hospitals in Jerusalem.

PMID- 29827831
TI  - The House-Governor Makes a Defence.

PMID- 29827832
TI  - The Design of the Quadrangle.

PMID- 29827833
TI  - A M.O.H. On Boots or No Boots.

PMID- 29827834
TI  - Drunk or Dying? A Common Conclusion on Insufficient Evidence.

PMID- 29827835
TI  - A Member of the Hospital Nursing Staff Articulates.

PMID- 29827836
TI  - A Ministry of Health for Scotland.

PMID- 29827837
TI  - Hospital and Institutional News.

PMID- 29827838
TI  - The Institutional Worker.

PMID- 29827839
TI  - The Local Honorary Secretary.

PMID- 29827840
TI  - The Commonplace Book.

PMID- 29827841
TI  - Round the Hospitals.

PMID- 29827842
TI  - The Right Policy. Choose Honest Workers and Trust Them.

PMID- 29827843
TI  - Unsound Conduct and Unsound Mind.

PMID- 29827844
TI  - The Guest Hospital, Dudley.

PMID- 29827846
TI  - The Voluntary Hospitals and the War.

PMID- 29827845
TI  - A "London" Certificated Nurse on "London" Nurses and Their Treatment.

PMID- 29827847
TI  - Building New Jerusalem: A Great Ideal to Be Attained.

PMID- 29827848
TI  - Letter from Colonel Maurice, C.M.G.

PMID- 29827849
TI  - Hospital and Institutional News.

PMID- 29827850
TI  - The Woman Workers' World.

PMID- 29827851
TI  - British Medical Students and Military Service.

PMID- 29827852
TI  - Games for the Men.

PMID- 29827853
TI  - From Viscount Knutsford.

PMID- 29827854
TI  - A Document of History.

PMID- 29827855
TI  - Teaching Hospitals.

PMID- 29827856
TI  - Erratum.
AB  - [This corrects the article on p. 331 in vol. 64.].

PMID- 29827858
TI  - Round the Hospitals.

PMID- 29827857
TI  - From Viscount Knutsford.

PMID- 29827859
TI  - Parliament and the Profession.

PMID- 29827860
TI  - From Major Chapple, M.P., R.A.M.C.

PMID- 29827861
TI  - As Made at the Pavilion General Hospital, Brighton: III. Amputation below the
      Knee-Syme's Excluded.

PMID- 29827862
TI  - The Medical Services of the Forces during the War.

PMID- 29827864
TI  - The Gospel of Self-Help.

PMID- 29827865
TI  - Some Experiences of Training-School Life: I. Does Training Harden Character?

PMID- 29827863
TI  - A Certain Liveliness in Blackburn.

PMID- 29827866
TI  - Gripped by Destructive Forces and Threatened with Disruption of Their
      Organisations.

PMID- 29827867
TI  - London as a Post-Graduation Medical School.

PMID- 29827869
TI  - Highlands and Islands Medical Service Board.

PMID- 29827868
TI  - The Institutional Worker.

PMID- 29827871
TI  - A State Medical Service in Detail.

PMID- 29827870
TI  - London Hospital Nurses.

PMID- 29827872
TI  - The Public Health.

PMID- 29827873
TI  - The Economic Value of the Penny.

PMID- 29827874
TI  - The Nurse and Her Newspaper.

PMID- 29827875
TI  - Case Records in a Teaching Hospital.

PMID- 29827877
TI  - The Harvest-Time for Voluntary Hospitals.

PMID- 29827876
TI  - The Order on Parasitic Mange.

PMID- 29827878
TI  - The Institutional Worker.

PMID- 29827879
TI  - Its Work and Development.

PMID- 29827880
TI  - Mothers, Babies, and the Little Bill.

PMID- 29827881
TI  - Matrons, and Nurse Agitators.

PMID- 29827882
TI  - The Legal Aspect of Madness.

PMID- 29827883
TI  - Hospital and Institutional News.

PMID- 29827885
TI  - Australian Notes.

PMID- 29827884
TI  - The Local Representative.

PMID- 29827887
TI  - Round the Hospitals.

PMID- 29827886
TI  - Should Nurses Live out?

PMID- 29827889
TI  - York County Hospital Inquiry: Report of Sir E. Cooper Perry, M.D., Commissioner,
      and Mr. Basil Watson, Legal Assessor.

PMID- 29827888
TI  - Substitutes for Lard and Olive Oil.

PMID- 29827891
TI  - Eastes v. Russ: An Interesting Case.

PMID- 29827890
TI  - From the Patient's Point of View.

PMID- 29827892
TI  - A Delayed Mental Hospital Appointment.

PMID- 29827893
TI  - A Loss to the Leeds Infirmary.

PMID- 29827894
TI  - The York County Hospital Inquiry.

PMID- 29827896
TI  - Bristol General Hospital.

PMID- 29827895
TI  - Mr. Balfour's Speech at the Opening of Guy's Hospital Medical School.

PMID- 29827898
TI  - The Institutional Worker.

PMID- 29827897
TI  - Guy's Hospital Medical School: The New Buildings of the Medical and Dental
      Schools Described.

PMID- 29827899
TI  - Hospital and Institutional News.

PMID- 29827900
TI  - The New Cardiff Medical School.

PMID- 29827902
TI  - Recent Legal Decisions.

PMID- 29827901
TI  - The Mayo Hospital, Rochester, U.S.A.: A Wonderful Example of Specialisation.

PMID- 29827903
TI  - Hospital and Institutional News.

PMID- 29827904
TI  - Wheeled Chairs for Paralytics.

PMID- 29827905
TI  - Institutional Needs.

PMID- 29827906
TI  - The Medico-Social Aspects of the Consumption Problem: II. The Incidence of
      Consumption.

PMID- 29827907
TI  - Amendment and Development of National Insurance.

PMID- 29827908
TI  - New Developments in Medicine.

PMID- 29827910
TI  - The New York System of Treatment.

PMID- 29827909
TI  - The Present and Future of the Poor-Law Infirmary.

PMID- 29827911
TI  - Hounslow Hospital, New Buildings.

PMID- 29827912
TI  - The Institutional Worker.

PMID- 29827913
TI  - Research and Remedies.

PMID- 29827914
TI  - The Mortality of the Tuberculous.

PMID- 29827915
TI  - The Value of a Man.

PMID- 29827916
TI  - The Haunt of the Ring Ouzel.

PMID- 29827917
TI  - Herbalists and Insured Persons.

PMID- 29827919
TI  - The Alcohol Treatment of Burns.

PMID- 29827918
TI  - Adenoid Disease in School Children.

PMID- 29827920
TI  - Hospital Sunday Special Number.

PMID- 29827921
TI  - Agreements between Approved Societies and Hospitals.

PMID- 29827922
TI  - Viscount Hill's and Dr. Giles's Speeches.

PMID- 29827923
TI  - The New Children's Hospital, Birmingham.

PMID- 29827924
TI  - York County Hospital: "Truth" on the Inquiry.

PMID- 29827925
TI  - Marasmus and Diphtheria.

PMID- 29827926
TI  - The Institutional Worker.

PMID- 29827927
TI  - The House-Fly and Public Health.

PMID- 29827929
TI  - The Modern Hospital in Metaphors.

PMID- 29827928
TI  - Hospital and Institutional News.

PMID- 29827930
TI  - Electricity in Modern Medicine: XXXI. Electricity in Ophthalmic Practice.

PMID- 29827931
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29827932
TI  - Valuation of Investments in Hospital Accounts: A Suggestion for Securing
      Uniformity.

PMID- 29827933
TI  - The New Tuberculosis Specialist.

PMID- 29827934
TI  - The Practical Training of the Royal Army Medical Corps.

PMID- 29827936
TI  - Its Site Can Accommodate 400 Beds.

PMID- 29827935
TI  - Septic and Aseptic Operating Theatres for Poor-Law Infirmaries: The Theory and
      Practice in England and Germany.

PMID- 29827937
TI  - The Hospital Isolation of Infectious Diseases: I. The History of Isolation.

PMID- 29827938
TI  - Every Man His Own Doctor.

PMID- 29827939
TI  - Will the Lord Lieutenant, the Bishop, or the Mayor of Worcester -One or All-Take
      Effective Action?

PMID- 29827940
TI  - Lady Williamson Memorial Home, Liverpool.

PMID- 29827941
TI  - The B.M.A. and the Medical Guild.

PMID- 29827942
TI  - The Extension of Radcliffe Infirmary, Oxford: A Tour of the New Block with
      Captain G. C. Rynd, Secretary.

PMID- 29827943
TI  - British Workers in Foreign Countries: With the Wounded in Montenegro-I.

PMID- 29827945
TI  - The Encouragement and Management of Breast-Feeding.

PMID- 29827944
TI  - A Woman's Experience in a Surgical Ward.

PMID- 29827946
TI  - The Report of the Departmental Committee on Poor-Law Orders.

PMID- 29827947
TI  - The Institutional Worker.

PMID- 29827948
TI  - The Haldane Commission and Medical Education in London: The Established System or
      the "University Ideal"?

PMID- 29827949
TI  - Research and Remedies.

PMID- 29827950
TI  - Probable Uses of Aerial Transport to the Medical Profession.

PMID- 29827951
TI  - Hospital and Institutional News.

PMID- 29827952
TI  - The Brighter Side of Mental Hospital Life: Patients' Tastes and Faculties for
      Amusement.

PMID- 29827954
TI  - The Hospitals and the Homes of England: Mr. Burns on Hospitals and Town Life.

PMID- 29827953
TI  - The Two Adjuncts of Sanatorium Treatment.

PMID- 29827956
TI  - The Proposed Amalgamation of St. George's and Westminster Hospitals.

PMID- 29827955
TI  - The Local Government Board Draft Nursing Order.

PMID- 29827957
TI  - The Control of Winsley Sanatorium: Breach of Agreement or Confiscation?

PMID- 29827958
TI  - Hospital and Institutional News.

PMID- 29827959
TI  - Powers and Immunities of Trade Unions.

PMID- 29827960
TI  - Almoners and Children's Aid Committees.

PMID- 29827961
TI  - Milk and Milk-Contracts : VIII. The Terms of a Milk-Contract.

PMID- 29827963
TI  - Oxford Conference, 1913.

PMID- 29827962
TI  - Paying Patients in General Hospitals: An Example from Kimberley.

PMID- 29827964
TI  - The Amending Bill.

PMID- 29827965
TI  - Resident Medical Officers and Ward Sisters: Friction the Exception: One Such
      Case.

PMID- 29827967
TI  - A New Vaccination Report.

PMID- 29827966
TI  - Legal Notes for Institutional Workers.

PMID- 29827968
TI  - Appointments and Their Confirmation.

PMID- 29827969
TI  - The Memorial to Sir Alfred Jones.

PMID- 29827970
TI  - The Control of Measles: The Value, as a Safeguard, of a Mild Epidemic.

PMID- 29827971
TI  - The Institutional Worker.

PMID- 29827972
TI  - Classification of the Phases of Diabetes.

PMID- 29827973
TI  - Experiences in a Metropolitan Asylums Board Hospital.

PMID- 29827974
TI  - "Hospitals from the Patients' Point of View" in a Provincial Hospital's
      Infectious Block.

PMID- 29827976
TI  - Model Locomotives as a Garden Hobby.

PMID- 29827975
TI  - Outline of a Scheme for Detection and Treatment.

PMID- 29827977
TI  - The Institutional Worker.

PMID- 29827978
TI  - Insomnia: Especially in Its Relationship to Dyspepsia.

PMID- 29827979
TI  - The Report on Poor-Law Orders: Points of Institutional Interest.

PMID- 29827980
TI  - A Moribund Community: Are the Citizens of Worcester Unique?

PMID- 29827982
TI  - The Decline in the Birth-Rate.

PMID- 29827981
TI  - British Workers in Foreign Countries: With the Wounded in Montenegro-II.

PMID- 29827983
TI  - Non-Panel Practitioners.

PMID- 29827984
TI  - Hospital and Institutional News.

PMID- 29827986
TI  - Research and Remedies.

PMID- 29827985
TI  - The Amendment Act.

PMID- 29827988
TI  - Electrically Self-Propelled Vehicles: American Experience of the Electrical
      Ambulance.

PMID- 29827987
TI  - The Institutional Life.

PMID- 29827989
TI  - Wandsworth Guardians and Administrative Reform.

PMID- 29827990
TI  - "Alexandra Day" for Cardiff.

PMID- 29827991
TI  - The Art of Drawing up Special Reports.

PMID- 29827992
TI  - Recent Advances in Cardiac Surgery.

PMID- 29827993
TI  - The Value of Open Spaces in Great Cities.

PMID- 29827994
TI  - Hospital and Institutional News.

PMID- 29827995
TI  - To Prevent Beds Damaging Walls.

PMID- 29827996
TI  - Should Panel Doctors Be Eligible for Honorary Staff Appointments?: The Duties of
      the Two Posts Compared.

PMID- 29827997
TI  - Institutional Needs.

PMID- 29827998
TI  - Wanted-A Revolution in British Nursing.

PMID- 29828000
TI  - Milk and Milk-Contracts: II. The Source of Institution Milk Supplies.

PMID- 29827999
TI  - The Institutional Worker.

PMID- 29828001
TI  - Present and Future of the Poor-Law Infirmary: Poor Law and Research.

PMID- 29828002
TI  - The Medico-Social Aspects of the Consumption Problem: III. Consumption Cures in
      Relation to Treatment.

PMID- 29828003
TI  - The New Ogilvie Children's Home: The Co-Operation between Health and Education.

PMID- 29828004
TI  - Arrangements with Herbalists.

PMID- 29828005
TI  - Tuberculin Dispensaries and the Public.

PMID- 29828006
TI  - Sir James Porter's Record as Medical Director-General.

PMID- 29828007
TI  - Amendment of Medical Benefit Regulations.

PMID- 29828008
TI  - Nature Notes.

PMID- 29828009
TI  - Hospital and Institutional News.

PMID- 29828010
TI  - Institutional Needs.

PMID- 29828011
TI  - The Reconstruction of Wolverhampton Hospital: Mr. J. S. Neil, Secretary, on the
      Transition.

PMID- 29828012
TI  - The Needs of the Queen's Hospital for Children.

PMID- 29828013
TI  - "Contraception" and Consumptives.

PMID- 29828015
TI  - Experiences in a London Nursing Home and Also in the Pay Wing of a Metropolitan
      General Hospital.

PMID- 29828014
TI  - Representation of Insured Persons on Insurance Committees.

PMID- 29828016
TI  - Research and Remedies.

PMID- 29828017
TI  - Eastes v. Russ.

PMID- 29828018
TI  - Modern Methods of Physical Treatment in Lung Diseases.

PMID- 29828019
TI  - The Hospital Patient's Point of View.

PMID- 29828020
TI  - Royal Society of Medicine.

PMID- 29828021
TI  - Mental Research and Government Aid.

PMID- 29828022
TI  - The New Mental Deficiency Bill.

PMID- 29828023
TI  - The Comic History of British Nursing.

PMID- 29828024
TI  - The Institutional Worker.

PMID- 29828025
TI  - Hydro-Electric Baths; Ionic Medication.

PMID- 29828026
TI  - Milk and Milk-Contracts : V. The Carriage of Milk.

PMID- 29828028
TI  - The Southwark Guardians and Guy's Hospital: Report by the Distribution Committee
      of King Edward's Hospital Fund.

PMID- 29828027
TI  - Hospitals and Unsold Newspapers: Lord Rowallan's Suggestion.

PMID- 29828029
TI  - Present and Future of the Poor-Law Infirmary: Septic Operations in Infirmaries.

PMID- 29828030
TI  - Guy's Hospital Appeal and Its Basis: What the Completion of the New Buildings
      Means.

PMID- 29828031
TI  - The Institutional Worker.

PMID- 29828033
TI  - National Insurance, Hospital Saturday and Insured Persons.

PMID- 29828032
TI  - The York County Hospital: Inquiry by Special Commission.

PMID- 29828034
TI  - The Medical Faculty of London University.

PMID- 29828035
TI  - Hospital and Institutional News.

PMID- 29828036
TI  - Approved Societies and District Nurses.

PMID- 29828037
TI  - Wealth's Opportunity.

PMID- 29828038
TI  - Research and Remedies.

PMID- 29828039
TI  - London Street Accidents.

PMID- 29828040
TI  - Present and Future of the Poor-Law Infirmary: Should Extra Fees Be Abolished?

PMID- 29828041
TI  - Diathermy.

PMID- 29828042
TI  - Red Cross Work in Turkey: The Experience of Two "Lay Helpers".

PMID- 29828043
TI  - Milk and Milk-Contracts : III. The Treatment of Institution Milk.

PMID- 29828044
TI  - The Institutional Worker.

PMID- 29828046
TI  - By the Way.

PMID- 29828045
TI  - Parents and Vivisection.

PMID- 29828048
TI  - Hospital and Institutional News.

PMID- 29828047
TI  - Wandsworth Guardians and Administrative Reform.

PMID- 29828050
TI  - The Mortuary Unit.

PMID- 29828049
TI  - Superfluous Hair: Some Methods of Treatment.

PMID- 29828051
TI  - The Value of the Patient's Criticism.

PMID- 29828052
TI  - The Research Defence Society.

PMID- 29828054
TI  - The Relation of Inspectors to Infirmary Superintendents: Dr. E. E. Norton,
      Brentford Union Infirmary, Gives His Views.

PMID- 29828053
TI  - Modern Campaign against Tuberculosis: The Work of a Tuberculosis Officer.

PMID- 29828056
TI  - Research and Remedies.

PMID- 29828055
TI  - The Idea of the Surgical "At Home."

PMID- 29828057
TI  - Proposed Pay-Wards at Charing Cross Hospital.

PMID- 29828058
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29828060
TI  - The Institutional Worker.

PMID- 29828059
TI  - Dr. Macqueen's Reply.

PMID- 29828061
TI  - Feeding and Insurance.

PMID- 29828063
TI  - The Haunt of the Ring Ouzel.

PMID- 29828062
TI  - York County Hospital: A Sister's View.

PMID- 29828065
TI  - Physical Exercises in Schools: Ceremonial Drill and Violin Playing.

PMID- 29828064
TI  - Co-Operation Once More.

PMID- 29828066
TI  - General Considerations-Static Electricity.

PMID- 29828067
TI  - Hampstead General and North-West London Hospital New Out-Patient Department.

PMID- 29828068
TI  - Hospital and Institutional News.

PMID- 29828070
TI  - Laboratory Methods in Relation to Tuberculosis: II. Sputum.

PMID- 29828069
TI  - York County Hospital: "Truth" and the Chairman of the House Committee.

PMID- 29828071
TI  - The Amendment of the Act.

PMID- 29828072
TI  - The Curious History of L'Hotel-Dieu De Paris : III. Its Connection with Medical
      Teaching.

PMID- 29828073
TI  - Institutional Needs.

PMID- 29828074
TI  - Present and Future of the Poor-Law Infirmary: A Poor-Law Pathological Institute.

PMID- 29828075
TI  - Fabian Deliverances on Sanatoria.

PMID- 29828076
TI  - The Ladies' Working Guild at Leeds.

PMID- 29828077
TI  - The Saturday Fund and Hospital Almoners.

PMID- 29828078
TI  - Research and Remedies.

PMID- 29828079
TI  - His Relations with the Teachers, Parents, and Children.

PMID- 29828080
TI  - The Annual Meeting of the Pharmaceutical Society.

PMID- 29828081
TI  - An Attack on the Almoner System: Adjourned Meeting of the Hospital Saturday Fund.

PMID- 29828082
TI  - The Doctor at Burlington House: Hospital Interest at the Academy.

PMID- 29828084
TI  - The Metropolitan Sunday Fund: New Draft Laws of the Constitution.

PMID- 29828083
TI  - The York County Hospital: A Mother's Statement.

PMID- 29828085
TI  - Hospital and Institutional News.

PMID- 29828086
TI  - The National Medical Guild: The First Success of the New Trade Union.

PMID- 29828087
TI  - Reforms in the Provision of Surgical Appliances.

PMID- 29828089
TI  - The Friendly Societies' Conferences.

PMID- 29828088
TI  - A Reasonable Limit for Panel Doctors.

PMID- 29828091
TI  - The Institutional Worker.

PMID- 29828090
TI  - Milk and Milk-Contracts.

PMID- 29828092
TI  - The Lighting of the Chiswick Hospital.

PMID- 29828093
TI  - Anterior Crural Neuritis.

PMID- 29828095
TI  - Clinical Clerks in Infirmaries.

PMID- 29828094
TI  - Institutional Needs.

PMID- 29828096
TI  - The Medico-Social Aspects of the Consumption Problem: Improvising Home
      Accommodation.

PMID- 29828097
TI  - Parliament and Research.

PMID- 29828098
TI  - A. Cornelius Celsus.

PMID- 29828099
TI  - Poor-Law Infirmary-Publications in 1912.

PMID- 29828100
TI  - Research and Remedies.

PMID- 29828101
TI  - Infirmary v. Hospital Architecture.

PMID- 29828102
TI  - The Present and Future of the Poor-Law Infirmary.

PMID- 29828103
TI  - The Scope of Infirmary Surgery To-Day.

PMID- 29828104
TI  - Preparation of Eye Instruments before Usage.

PMID- 29828106
TI  - The Case for the Ward Dressing Room.

PMID- 29828105
TI  - Hospital and Institutional News.

PMID- 29828107
TI  - The Institutional Worker.

PMID- 29828108
TI  - The Infirmary and Signs of Change.

PMID- 29828109
TI  - The Fulham Infirmary.

PMID- 29828110
TI  - Nursing under the Poor Law.

PMID- 29828112
TI  - A Result of National Insurance.

PMID- 29828111
TI  - Medical Missions.

PMID- 29828114
TI  - Institutional Needs.

PMID- 29828113
TI  - The Medico-Social Aspects of the Consumption Problem: I. Ideals and
      Possibilities.

PMID- 29828115
TI  - A Practical Reform in Casual Wards: Mr. John Burns as Administrator.

PMID- 29828116
TI  - The Royal Photographic Society's Exhibition: Examples of Radiographs,
      Photomicrography, and Colour Work.

PMID- 29828117
TI  - Remodelling of North Staffordshire Infirmary: The Raising and Results of a
      Successful Appeal.

PMID- 29828118
TI  - The Log of the Ship's Surgeon.

PMID- 29828120
TI  - Hospital and Institutional News.

PMID- 29828119
TI  - Modern Economy in Sanatorium Management.

PMID- 29828121
TI  - The Institutional Worker.

PMID- 29828122
TI  - The Constitution of the B.M.A.

PMID- 29828123
TI  - Insomnia: Especially in Relation to Dyspepsia.

PMID- 29828125
TI  - Representation and the Voluntary System: A Share in the Management as a Bait for
      Income.

PMID- 29828124
TI  - The Decline in the Birth-Rate.

PMID- 29828126
TI  - Arrears of Contribution.

PMID- 29828127
TI  - Poor-Law Infirmaries as Training Schools.

PMID- 29828128
TI  - The Asylums Board and Sick Children: Inhumanity or Progress?

PMID- 29828130
TI  - Trade Unionism: What Its Absence Permits.

PMID- 29828129
TI  - Panel Doctors and Prescription Writing.

PMID- 29828131
TI  - The Liverpool Policy and the Voluntary System.

PMID- 29828132
TI  - Hospital and Institutional News.

PMID- 29828133
TI  - Prompt Reform Needed in Poor-Law Nursing of the Sick.

PMID- 29828134
TI  - An Instance of Infirmary Development and Progress.

PMID- 29828136
TI  - Reflections in a Surgical Ward.

PMID- 29828135
TI  - Errata.
AB  - [This corrects the article on p. 293 in vol. 54.].

PMID- 29828137
TI  - The South London Hospital for Women.

PMID- 29828138
TI  - Verification of Death.

PMID- 29828139
TI  - Following up.

PMID- 29828140
TI  - Dr. Harding, Berry Wood, Northampton, Gives His Views.

PMID- 29828141
TI  - Conflict of Medical Evidence as to Personal Injury.

PMID- 29828142
TI  - Erratum: A Comic History of British Nursing.
AB  - [This corrects the article on p. 622 in vol. 53.].

PMID- 29828143
TI  - New Canadian Hospital Opened by the Queen.

PMID- 29828144
TI  - York County Hospital.

PMID- 29828145
TI  - Research and Remedies.

PMID- 29828146
TI  - The Institutional Worker.

PMID- 29828147
TI  - The Role of the General Practitioner.

PMID- 29828148
TI  - The Four Insurance Commissions.

PMID- 29828149
TI  - West London Hospital: The Late Duke of Abercorn.

PMID- 29828150
TI  - Milk and Milk-Contracts.

PMID- 29828151
TI  - The London Hospital and the National Insurance Act.

PMID- 29828152
TI  - State Registration.

PMID- 29828153
TI  - Annual Meeting of the Governors and General Council.

PMID- 29828154
TI  - The State Registration of Nurses.

PMID- 29828155
TI  - Hospital Staffs and Medical Benefit.

PMID- 29828156
TI  - Encouraging Children to Support the Hospitals.

PMID- 29828157
TI  - National Insurance and Unqualified Practitioners.

PMID- 29828158
TI  - The Institutional Worker.

PMID- 29828159
TI  - York County Hospital Inquiry.

PMID- 29828161
TI  - The Cure of Gall-Stones: An Alternative Diagnostic Method.

PMID- 29828160
TI  - Research and Remedies.

PMID- 29828162
TI  - Static Electricity-High Frequency Currents.

PMID- 29828163
TI  - Mr. Asquith and Nurse Registration.

PMID- 29828164
TI  - Institutional Needs.

PMID- 29828165
TI  - The Artificial Lighting of Hospital Wards.

PMID- 29828166
TI  - The Twining Memorial Clock.

PMID- 29828167
TI  - Herbalists and the Panels.

PMID- 29828168
TI  - Appendicitis in Young Children.

PMID- 29828169
TI  - Malingering as an Actual Risk.

PMID- 29828170
TI  - Milk and Milk-Contracts: I. Institution Milk Supplies.

PMID- 29828171
TI  - The Metropolitan Asylums Board and Their Staff.

PMID- 29828172
TI  - Fulham Parish Infirmary Nurses' Home.

PMID- 29828173
TI  - The Wandsworth Guardians and Administrative Reform: A Suggested Scheme of
      Centralised Control.

PMID- 29828174
TI  - Hospital and Institutional News.

PMID- 29828175
TI  - Poor-Law Infirmaries as Training Schools: A Consultative Staff for Poor-Law
      Institutions.

PMID- 29828176
TI  - Representation and the Voluntary System.

PMID- 29828177
TI  - The Control of Venereal Disease in Denmark: Provision for Treatment and
      Impersonal Notification.

PMID- 29828178
TI  - Hospital and Institutional News.

PMID- 29828179
TI  - The National Medical Guild: A Cash Alternative to Medical Benefit.

PMID- 29828181
TI  - The True Anti-Phthisis Unit.

PMID- 29828180
TI  - A Hospital Officer's Experiences in a Nursing Home.

PMID- 29828182
TI  - The Hospital Isolation of Infectious Diseases: IV. Administrative Difficulties in
      Small Isolation Hospitals.

PMID- 29828183
TI  - The Metropolitan Asylums Board and Sick Children: Inhumanity or Progress?

PMID- 29828184
TI  - An Aid to Economy: The Importance of Analysing Expenditure.

PMID- 29828185
TI  - The New General Hospital, Toronto.

PMID- 29828186
TI  - The Proposed Royal Commission in Relation to Maternity.

PMID- 29828188
TI  - Quinine and Insomnia.

PMID- 29828187
TI  - Further Advantages Conferred by the Amendment Act.

PMID- 29828189
TI  - The Institutional Worker.

PMID- 29828190
TI  - The Control of Overcrowding in Workhouses.

PMID- 29828192
TI  - Poor-Law Out-Patient Departments.

PMID- 29828191
TI  - Defects of the Eye and Methods of Test.

PMID- 29828193
TI  - The Institutional Worker.

PMID- 29828194
TI  - Hospital and Institutional News.

PMID- 29828195
TI  - Examination of the Respiratory System.

PMID- 29828196
TI  - The British Hospitals Association: Fourth Annual Conference at Oxford.

PMID- 29828197
TI  - Tuberculosis and the General Hospital.

PMID- 29828198
TI  - Its Origin, History, and Objects.

PMID- 29828199
TI  - The Malingering Problem.

PMID- 29828200
TI  - The Notification of Puerperal Fever: Some Arguments in Favour of Its Abolition.

PMID- 29828202
TI  - The Historical Medical Museum.

PMID- 29828201
TI  - Erratum.
AB  - [This corrects the article on p. 383 in vol. 54.].

PMID- 29828203
TI  - Guild Notes.

PMID- 29828204
TI  - The Amending Bill.

PMID- 29828205
TI  - The Tenure of Hospital Staff Appointments: Staff Elections in the United States.

PMID- 29828206
TI  - Institutional Needs.

PMID- 29828208
TI  - A Necessary Reform in the Telephone Directory.

PMID- 29828207
TI  - The British Hospital System, Its Efficiency and Need for Development.

PMID- 29828209
TI  - The Gymnasium at the Virchow Krankenhaus.

PMID- 29828210
TI  - The London School of Tropical Medicine: Its Latest Developments in Building and
      Teaching.

PMID- 29828211
TI  - Efficiency in First-Aid Work.

PMID- 29828212
TI  - The Profession and Government "Blacklegs".

PMID- 29828213
TI  - Dissenters and Medical Authority.

PMID- 29828214
TI  - Dr Neal and the Poor-Law Service.

PMID- 29828216
TI  - Research and Remedies.

PMID- 29828215
TI  - The Growth of Municipal Sanatoria: Their Administration, Work, and Aims.

PMID- 29828218
TI  - The Institutional Worker.

PMID- 29828217
TI  - Telephones in Hospitals: Rival Systems and Improvements Compared.

PMID- 29828219
TI  - Open-Air Wards in Australia: The New Surgical Pavilion at Brisbane Hospital,
      Queensland.

PMID- 29828220
TI  - The Report on the Draft Poor-Law Order: The Needs of the Sick in the Smaller
      Rural Workhouses.

PMID- 29828221
TI  - Institutional Needs.

PMID- 29828222
TI  - Hospital and Institutional News.

PMID- 29828223
TI  - Advantages Conferred by the Amendment Act.

PMID- 29828224
TI  - Foods Department of the Local Government Board.

PMID- 29828225
TI  - The English Conjoint Course.

PMID- 29828226
TI  - Panel Practice and the Future of Partnerships.

PMID- 29828228
TI  - Hospital and Institutional News.

PMID- 29828227
TI  - A Patient's Sanatorium Experiences.

PMID- 29828230
TI  - London Post-Graduate Institutions.

PMID- 29828229
TI  - Medical Journalism as a Career: The Available Openings on the Hospital Press.

PMID- 29828231
TI  - Higher Diplomas.

PMID- 29828232
TI  - The Position and Future of the Panel: A Survey of Conditions in Town and Country.

PMID- 29828233
TI  - The Medical Guild and the B.M.A.

PMID- 29828235
TI  - The Position of Panel and Non-Panel Practitioners.

PMID- 29828234
TI  - The Institutional Worker.

PMID- 29828237
TI  - The Study of Tropical Medicine.

PMID- 29828236
TI  - Antagonists of Medical Authority.

PMID- 29828238
TI  - The Scarcity of Resident Medical Officers: The Facts, the Cause, and the Remedy.

PMID- 29828240
TI  - The Tendency of Medical Education.

PMID- 29828239
TI  - Hospital Branch of the Poor-Law Medical Service.

PMID- 29828241
TI  - The Funds of Trade Unions.

PMID- 29828242
TI  - The Asylums Board and Sick Children: Inhumanity or Progress?

PMID- 29828243
TI  - Ships' Surgeons: A Holiday or a Profession.

PMID- 29828244
TI  - The London University Course.

PMID- 29828245
TI  - Qualification and Registration.

PMID- 29828246
TI  - The Tuberculosis Service.

PMID- 29828247
TI  - The National Medical Guild.

PMID- 29828248
TI  - The Public Services.

PMID- 29828249
TI  - The Cambridge University Course.

PMID- 29828250
TI  - Views of the Midlands on Worcester Infirmary.

PMID- 29828251
TI  - The Medical Schools of the United Kingdom.

PMID- 29828252
TI  - The Hop-Pickers' Hospital Dilemma.

PMID- 29828253
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29828254
TI  - Opportunities for Graduate Study in Special Hospitals.

PMID- 29828255
TI  - Oxford University.

PMID- 29828257
TI  - The Treatment of the Puerpeirum.

PMID- 29828256
TI  - The Institutional Worker.

PMID- 29828259
TI  - New Views of Chronic Bright's Disease: Functional Tests as a Basis of
      Classification.

PMID- 29828258
TI  - Investigation of Complaints against Panel Doctors.

PMID- 29828260
TI  - The Medical Research Committee.

PMID- 29828261
TI  - Mr. Lloyd George's Amending Bill.

PMID- 29828262
TI  - Present and Future of the Poor-Law Infirmary: Bacteriological Research in
      Infirmaries.

PMID- 29828263
TI  - Hospital and Institutional News.

PMID- 29828264
TI  - The Hospital Sunday Fund.

PMID- 29828265
TI  - The Work of Incurable Patients: Inmates' Sale of Work at the Royal Hospital,
      Putney.

PMID- 29828266
TI  - Revision of the Laws of the Constitution.

PMID- 29828267
TI  - Research and Remedies.

PMID- 29828268
TI  - Eddowes and Others v. St. John's Hospital: The Tenure of Hospital Staff
      Appointments.

PMID- 29828269
TI  - Milk and Milk-Contracts : VII. The Rational Basis of a Milk-Contract.

PMID- 29828270
TI  - Warm Weather Dietetics: The Scientific Apportioning of a Summer Diet.

PMID- 29828272
TI  - A Question of Sanatorium Control.

PMID- 29828271
TI  - The St. John's Hospital Case: A Legal Synopsis.

PMID- 29828274
TI  - A Question of Sanatorium Control.

PMID- 29828273
TI  - Recent Legal Decisions.

PMID- 29828275
TI  - A Nurse's Experiences in Nursing Homes.

PMID- 29828276
TI  - Professional Mental Instability and Its Dangers.

PMID- 29828277
TI  - County Hospital Administration at Worcester.

PMID- 29828278
TI  - A Woman's Experience in a Surgical Ward.

PMID- 29828280
TI  - The Coming Control of Syphilis.

PMID- 29828279
TI  - Hospital and Institutional News.

PMID- 29828282
TI  - The Position of the School Doctor: The Board of Education Supports "The
      Hospital."

PMID- 29828281
TI  - Beginners' Mistakes in Tuberculosis Work.

PMID- 29828283
TI  - Tuberculin Treatment in Sheffield.

PMID- 29828284
TI  - The Amendment Bill.

PMID- 29828285
TI  - The Exhibition of the Seventeenth International Congress of Medicine: An
      Attractive Display at the Imperial Institute.

PMID- 29828287
TI  - Institutional Needs.

PMID- 29828286
TI  - The Institutional Worker.

PMID- 29828288
TI  - Should Workhouse Matrons Be Trained Nurses?

PMID- 29828289
TI  - The International Congress of Medicine: An Expert Synopsis of the Proceedings.

PMID- 29828290
TI  - East Suffolk and Ipswich Hospital.

PMID- 29828291
TI  - The British Medical Association Meeting at Brighton: A Great Address by Sir
      Berkeley Moynihan.

PMID- 29828293
TI  - Hospital and Institutional News.

PMID- 29828292
TI  - Worcester Hospitals' Monthly Collections Scheme.

PMID- 29828294
TI  - National Insurance and the Voluntary Hospitals: The Hon. Harry Lawson Defends the
      Hospitals.

PMID- 29828295
TI  - The Institutional Worker.

PMID- 29828296
TI  - Crime and Punishment.

PMID- 29828297
TI  - Hospitals in Relation to the State, the Public, and the Medical Profession.

PMID- 29828298
TI  - The Proposed Royal Commission.

PMID- 29828299
TI  - Guild Notes.

PMID- 29828300
TI  - Our Hospitals: Their Future Organisation and Work.

PMID- 29828301
TI  - The Editor's Letter-Box.

PMID- 29828302
TI  - The Annual Meeting of the B.M.A. at Brighton.

PMID- 29828304
TI  - Saline Injections in Infantile Diarrhoea.

PMID- 29828303
TI  - Women as Doctors.

PMID- 29828305
TI  - The Amending Bill.

PMID- 29828306
TI  - St. Andrew's Hospital, Dollis Hill, Willesden.

PMID- 29828307
TI  - Institutional Needs.

PMID- 29828308
TI  - Amalgamation of St. George's and Westminster Hospitals: Unanimous Approval by the
      St. George's Governors.

PMID- 29828310
TI  - An Exposition of the Guild Rules.

PMID- 29828309
TI  - The Institutional Worker.

PMID- 29828311
TI  - Poor-Law Infirmaries as Training Schools.

PMID- 29828312
TI  - Research and Remedies.

PMID- 29828313
TI  - Saline Injections in Infantile Diarrhoea.

PMID- 29828314
TI  - The Mount Vernon Hospital Dispute.

PMID- 29828315
TI  - A Warning from "Bart.'s".

PMID- 29828316
TI  - The Michael Reese Hospital, Chicago.

PMID- 29828317
TI  - A. Cornelius Celsus.

PMID- 29828318
TI  - St. George's and Westminster Hospitals' Amalgamation.

PMID- 29828319
TI  - Acidosis in Children.

PMID- 29828320
TI  - The Hospital Isolation of Infectious Diseases: Some Arguments for and against
      Isolation.

PMID- 29828321
TI  - Hospital and Institutional News.

PMID- 29828322
TI  - A Woman's Experience in a General Hospital.

PMID- 29828323
TI  - Hospital and Institutional News.

PMID- 29828324
TI  - Institutional Needs.

PMID- 29828325
TI  - Prognosis in Heart Cases.

PMID- 29828326
TI  - Queen Mary's Hospital for Children, Carshalton.

PMID- 29828328
TI  - An Exposition of the Guild Rules.

PMID- 29828327
TI  - The Newer Treatments of Syphilis: Some Possible Sociological Effects.

PMID- 29828329
TI  - Maternity Endowments under the Insurance Act.

PMID- 29828330
TI  - Women as Doctors: Professor Hochenegg's Views on This Question.

PMID- 29828332
TI  - Should Leeds Have a Children's Hospital?

PMID- 29828331
TI  - Central London Ophthalmic Hospital.

PMID- 29828334
TI  - Legal Notes for Institutional Workers.

PMID- 29828333
TI  - Income Raising for Voluntary Hospitals.

PMID- 29828335
TI  - The First Report on the Administration of the Act.

PMID- 29828336
TI  - Research and Remedies.

PMID- 29828337
TI  - Medical Administrators: A Lesson from the Poor Law.

PMID- 29828338
TI  - The Seventeenth International Congress of Medicine: Notabilities and Notable
      Items.

PMID- 29828340
TI  - The Lady Chichester Hospital, Brighton.

PMID- 29828339
TI  - Royal Infirmary, Edinburgh, and Insured Persons.

PMID- 29828341
TI  - The Institutional Worker.

PMID- 29828342
TI  - Saline Injections in Infantile Diarrhoea.

PMID- 29828343
TI  - Are Hospital Patients Over-Fed?

PMID- 29828344
TI  - The Metropolitan Hospital Sunday Fund: List of Awards Distributed.

PMID- 29828346
TI  - The Institutional Worker.

PMID- 29828345
TI  - Report of the Committee of Distribution to the Council.

PMID- 29828348
TI  - The Editor's Letter-Box.

PMID- 29828347
TI  - The International Medical Congress.

PMID- 29828349
TI  - The Safeguards of Maternity Benefit.

PMID- 29828350
TI  - Hospital and Institutional News.

PMID- 29828351
TI  - The Editor's Letter-Box.

PMID- 29828353
TI  - The Financial Crisis at Worcester Infirmary: Its Future as a Training School.

PMID- 29828352
TI  - The Hospital Isolation of Infectious Diseases: III. Recent Methods of Isolation
      and Nursing.

PMID- 29828354
TI  - The Society for the State Registration of Trained Nurses.

PMID- 29828355
TI  - Hospital for Epilepsy and Paralysis: Princess Louise Opens the Completed
      Building.

PMID- 29828356
TI  - The Editor's Letter-Box.

PMID- 29828357
TI  - Mount Vernon Hospital.

PMID- 29828359
TI  - The Progress of Cancer Research: The Need for International Co-Operation.

PMID- 29828358
TI  - Backward Displacement of the Womb and the Mineral Salts of Our Foods.

PMID- 29828361
TI  - The King at Royal West Sussex Hospital: The Reconstruction Scheme Described in
      Detail.

PMID- 29828360
TI  - Special Treatments of Consumption: The Continental Expedient of Rib-Cutting.

PMID- 29828363
TI  - The Objections of the Profession to Trade Unions.

PMID- 29828362
TI  - Institutional Needs.

PMID- 29828364
TI  - The Amending Bill in Committee.

PMID- 29828365
TI  - The Medico-Sociological Section at Brighton.

PMID- 29828367
TI  - Hospital and Institutional News.

PMID- 29828366
TI  - Huge Task for Ministry of Pensions.

PMID- 29828369
TI  - The Pure Milk Problem.

PMID- 29828368
TI  - Presentation to Miss Ray.

PMID- 29828370
TI  - The Judge's Report.

PMID- 29828371
TI  - The Right to Send Private Patients to District Hospitals.

PMID- 29828372
TI  - The Prize Winners with Selected Papers.

PMID- 29828373
TI  - The Communion Cup and Infection.

PMID- 29828374
TI  - Medical Reconstruction and Graduate Teaching.

PMID- 29828375
TI  - Round the Hospitals.

PMID- 29828376
TI  - Discharged Officers and Their Outlook: Hundreds Seeking Employment.

PMID- 29828377
TI  - The Histrionic Temperament: The Poseur.

PMID- 29828378
TI  - Another Experiment in Articulation.

PMID- 29828379
TI  - Tuberculosis Topics.

PMID- 29828380
TI  - Notes and Memoranda for Hospital Buyers.

PMID- 29828382
TI  - Many Races at the War: I. With Native Labour Corps in France.

PMID- 29828381
TI  - State or National Medical Service.

PMID- 29828383
TI  - The B.M.A. and the Law of the Land.

PMID- 29828384
TI  - Mind Your Own Business!

PMID- 29828386
TI  - Searching for the Solution.

PMID- 29828385
TI  - Round the Hospitals.

PMID- 29828387
TI  - The Voluntary Hospital System and the Proposed Ministry of Health.

PMID- 29828388
TI  - Its International Aims and Position To-Day.

PMID- 29828389
TI  - An Appreciation of "Ierne," by a Nurse with Service and Decorations.

PMID- 29828391
TI  - The Rural Population.

PMID- 29828390
TI  - A Fulham Infirmary Nursing League.

PMID- 29828392
TI  - Mr. Morris and Lord Knutsford.

PMID- 29828393
TI  - British Hospitals after the War.

PMID- 29828394
TI  - Parliament and the Profession.

PMID- 29828395
TI  - The History of Epidemic Influenza.

PMID- 29828396
TI  - Ireland's "Lusitania".

PMID- 29828397
TI  - Hospital and Institutional News.

PMID- 29828399
TI  - The Treatment of Incipient Madness.

PMID- 29828398
TI  - The Training-Schools Must Lead.

PMID- 29828400
TI  - Sir James Barr and the Medical Profession.

PMID- 29828401
TI  - A Record of Personal Experiences.

PMID- 29828402
TI  - Serving the King's Men.

PMID- 29828403
TI  - Where the College of Nursing Stands.

PMID- 29828404
TI  - Statement by Dr. Addison.

PMID- 29828405
TI  - Aberdeen Shows the Way: One Day a Week off Duty.

PMID- 29828406
TI  - Jezreel.

PMID- 29828407
TI  - Special Knowledge of Flying Conditions Imperative.

PMID- 29828408
TI  - The Present Position and Some Resulting Troubles.

PMID- 29828409
TI  - "Nurses Are Shamefully Underpaid": A Step on the Way.

PMID- 29828410
TI  - Major Chapple, M.P.'s, Reply to Mr. Morris.

PMID- 29828411
TI  - Round the Hospitals.

PMID- 29828412
TI  - Hospital and Institutional News.

PMID- 29828413
TI  - The Medical Profession in Parliament: Sir Henry Morris, Bart., F.R.C.S., on Its
      Representation.

PMID- 29828414
TI  - The Local Honorary Treasurer.

PMID- 29828415
TI  - The Hollow Square: A Rejoinder.

PMID- 29828417
TI  - Wake up, College of Nursing.

PMID- 29828416
TI  - The League of Mercy and Its Future.

PMID- 29828418
TI  - A Woman's Ideas of Peace.

PMID- 29828419
TI  - King Edward's Hospital Fund for London.

PMID- 29828420
TI  - Lady Roberts' Field Glass Fund.

PMID- 29828421
TI  - The Strike in Lloyd's Tobacco Factory.

PMID- 29828423
TI  - What We Expect from the College of Nursing.

PMID- 29828422
TI  - Annual Meeting of the Constituents.

PMID- 29828424
TI  - National Thanksgiving and How to Show It.

PMID- 29828425
TI  - Hospital and Institutional News.

PMID- 29828427
TI  - The Chaplain's Story.

PMID- 29828426
TI  - Round the Hospitals.

PMID- 29828428
TI  - The First Christmas after the Armistice.

PMID- 29828429
TI  - The Editor's Letter-Box.

PMID- 29828431
TI  - Keep Your Friendships in Repair.

PMID- 29828430
TI  - A Pioneer Matron: Thirty-Five Years' Hospital Work.

PMID- 29828432
TI  - Hospital and Institutional News.

PMID- 29828433
TI  - Progress and Policy.

PMID- 29828434
TI  - The Woman Worker's World.

PMID- 29828435
TI  - The Shortage of M.A.B. Nurses.

PMID- 29828436
TI  - Some Probationers Articulate.

PMID- 29828437
TI  - Prevention of Lice-Borne Diseases: Two Disinfectors That Kill.

PMID- 29828438
TI  - The London Hospital's Nurses.

PMID- 29828439
TI  - Round the Hospitals.

PMID- 29828440
TI  - The Nightingale Legend: The Reaction and the Reality.

PMID- 29828442
TI  - The Hospitals' Future and Medical Practice.

PMID- 29828441
TI  - The Treatment of Incipient Madness.

PMID- 29828443
TI  - Provisional Artificial Limbs.

PMID- 29828445
TI  - Dr. Voelcker's Address on Regeneration.

PMID- 29828444
TI  - Boots or No Boots: The Advantages of Clogs.

PMID- 29828446
TI  - Four Ceremonies: The Cavell Statue, Her Memorial, King Edward VII. Ward, and the
      Bishop's Palace.

PMID- 29828447
TI  - The Public Health.

PMID- 29828448
TI  - Round the Hospitals.

PMID- 29828449
TI  - The Hospitals and the Epidemic.

PMID- 29828450
TI  - Mr. Brudenell Carter, F.R.C.S.: A Man of Principle in Medical Practice.

PMID- 29828451
TI  - A Place to Which Ambulant Patients Come.

PMID- 29828453
TI  - A Ministry of Health.

PMID- 29828452
TI  - Some of "Ierne's" Questions Answered?

PMID- 29828454
TI  - Parliament and the Profession.

PMID- 29828455
TI  - Economics and a Vocation.

PMID- 29828457
TI  - Many Races at the War: II. With Native Labour Corps in France.

PMID- 29828456
TI  - Additional Fuel Allowances.

PMID- 29828459
TI  - Hospital and Institutional News.

PMID- 29828458
TI  - Nine Months' Work and Progress.

PMID- 29828460
TI  - The Health of the People and the Ministry of Health.

PMID- 29828461
TI  - Public Health and Public Opinion.

PMID- 29828462
TI  - Some Things Training-Schools Have Done.

PMID- 29828463
TI  - Conference at Hull.

PMID- 29828465
TI  - Summaries of "Case" Medicine.

PMID- 29828464
TI  - Probationer Nurses Who Need a Champion.

PMID- 29828466
TI  - A Public-Spirited Governor.

PMID- 29828467
TI  - Doctors in Parliament.

PMID- 29828468
TI  - Two Provincial Workers Join in.

PMID- 29828469
TI  - The London Hospital's Nurses.

PMID- 29828471
TI  - Metropolitan Asylums Board Contracts.

PMID- 29828470
TI  - "Ierne" Taken to Task.

PMID- 29828472
TI  - Round the Hospitals.

PMID- 29828473
TI  - Some Staff Nurses' Views.

PMID- 29828474
TI  - Children's Departments.

PMID- 29828475
TI  - The Nation's Tribute. Importance of Locality.

PMID- 29828476
TI  - Science and the Prevention and Cure of Disease.

PMID- 29828477
TI  - Hospital and Institutional News.

PMID- 29828478
TI  - Nurses' Emoluments, Hours, and Holidays.

PMID- 29828479
TI  - Viscount Knutsford's Letter.

PMID- 29828480
TI  - An Autobiographical Discussion.

PMID- 29828482
TI  - The Medical Profession as a National Service.

PMID- 29828481
TI  - The Irish Nurses' Tribute Fund.

PMID- 29828484
TI  - Things Spiritual and Economic.

PMID- 29828483
TI  - The Case of the Discharged Consumptive.

PMID- 29828486
TI  - The Post of Matron.

PMID- 29828485
TI  - A Vision of State Medical Service.

PMID- 29828487
TI  - Parliament and the Profession.

PMID- 29828488
TI  - The Incidence and Treatment of Disease.

PMID- 29828490
TI  - Mrs. George at Cardiff.

PMID- 29828489
TI  - On Physiognomy.

PMID- 29828491
TI  - Round the Hospitals.

PMID- 29828492
TI  - Hospital and Institutional News.

PMID- 29828493
TI  - What Ministry of Health Bill Must Not Be.

PMID- 29828494
TI  - Military and Overseas Matrons-In-Chief.

PMID- 29828495
TI  - Military Nursing Services of the Crown.

PMID- 29828496
TI  - Parliament and the Professions.

PMID- 29828498
TI  - From Amazon to Hospital Nurse.

PMID- 29828497
TI  - State Medical Service.

PMID- 29828500
TI  - The Universities and Parliament.

PMID- 29828499
TI  - Higher Education and Nurses' Needs.

PMID- 29828502
TI  - Round the Hospitals.

PMID- 29828501
TI  - Human Incineration.

PMID- 29828503
TI  - The Late Miss Atkinson.

PMID- 29828505
TI  - An Absence of Statesmanship in B.M.A. Policy.

PMID- 29828504
TI  - Co-Operative Appeals.

PMID- 29828506
TI  - Hospital and Institutional News.

PMID- 29828507
TI  - Asylum Visiting Committees in Conference.

PMID- 29828508
TI  - Hospital Clinical Services and the New Age.

PMID- 29828509
TI  - The Nurses' Tribute, Everybody's Business.

PMID- 29828510
TI  - Nurse Alice Petitt's Articulation.

PMID- 29828511
TI  - A Fragment.

PMID- 29828512
TI  - Some American Methods.

PMID- 29828513
TI  - A New and Instructive Study by Dr. Brownlee.

PMID- 29828514
TI  - Is the National Stamina Lowered?

PMID- 29828516
TI  - Royal British Nurses' Association Meeting.

PMID- 29828515
TI  - The Influenza Crisis at Birmingham.

PMID- 29828518
TI  - Is Every Woman a Nurse?

PMID- 29828517
TI  - The Treatment of Disabled Men.

PMID- 29828519
TI  - The Nurse's Part in Nursing Reforms.

PMID- 29828520
TI  - A Plea for Co-Operative Homes for Workers.

PMID- 29828522
TI  - Heredity and Health.

PMID- 29828521
TI  - The Ministry of Health and the Teaching Hospitals.

PMID- 29828523
TI  - Should the Nurse Articulate?

PMID- 29828524
TI  - The Epidemic and the Public.

PMID- 29828525
TI  - My Fellow-Probationer.

PMID- 29828526
TI  - Hospital and Institutional News.

PMID- 29828527
TI  - Round the Hospitals.

PMID- 29828528
TI  - A State Medical Service.

PMID- 29828529
TI  - Each British Woman to Be Stirred up?

PMID- 29828531
TI  - The Future and the Nation's Choice.

PMID- 29828530
TI  - School Medical Inspection and Its Influences.

PMID- 29828532
TI  - Influenza and Pneumonia Rampant: Five Days without a Nurse.

PMID- 29828533
TI  - "The Hospital" and the Present Position.

PMID- 29828535
TI  - Hospital and Institutional News.

PMID- 29828534
TI  - State Medical Service.

PMID- 29828537
TI  - The Need for Organisation.

PMID- 29828536
TI  - The Leeds General Infirmary.

PMID- 29828538
TI  - Can Treaties Abolish Gas Warfare?

PMID- 29828539
TI  - Meeting of Council.

PMID- 29828540
TI  - A Front Line Club Suggested.

PMID- 29828541
TI  - The Spirit of Co-Operation.

PMID- 29828542
TI  - An Open Discussion Invited.

PMID- 29828543
TI  - Round the Hospitals.

PMID- 29828544
TI  - Meeting at St. Thomas's Hospital.

PMID- 29828545
TI  - Should the Nurse Articulate?

PMID- 29828546
TI  - Heavy Influenza Death Roll.

PMID- 29828547
TI  - Fenwickism and How to Fight It.

PMID- 29828548
TI  - A Patient's Protest.

PMID- 29828549
TI  - The Work of St. Thomas's in Lambeth, by Mr. G. Q. Roberts.

PMID- 29828550
TI  - The Place of the Hospitals.

PMID- 29828551
TI  - Hospital and Institutional News.

PMID- 29828552
TI  - Wake up, College of Nursing.

PMID- 29828553
TI  - An American Nurse's View.

PMID- 29828555
TI  - Round the Hospitals.

PMID- 29828554
TI  - The Editor's Letter-Box.

PMID- 29828556
TI  - The Call for Reconstruction.

PMID- 29828557
TI  - Our Hospitals' Christmas, 1918.

PMID- 29828558
TI  - Developments in Heliotherapy.

PMID- 29828559
TI  - An Evil Which Must Be Ended.

PMID- 29828560
TI  - The College Programme.

PMID- 29828561
TI  - The Editor's Letter-Box.

PMID- 29828562
TI  - Sir George Newman's Report.

PMID- 29828563
TI  - The Ministry of Pensions. Prompt Reorganisation Essential.

PMID- 29828564
TI  - Medicines, Morals and Manifestoes.

PMID- 29828565
TI  - The Swan-Song of a Great Matron-In-Chief.

PMID- 29828567
TI  - Hospital and Institutional News.

PMID- 29828566
TI  - The Institutional Treatment of Tuberculosis.

PMID- 29828568
TI  - Medicine and Politics.

PMID- 29828569
TI  - Demobilisation or Resurrection in Ireland.

PMID- 29828570
TI  - Influenza Epidemic in South Africa: Fifty Thousand Deaths.

PMID- 29828571
TI  - A Moralisation on Games.

PMID- 29828572
TI  - On Titular and Other Decorations.

PMID- 29828573
TI  - Control of Post-War Venereal Disease.

PMID- 29828574
TI  - A Crisis and Its Solution.

PMID- 29828575
TI  - Medico-Political Union's Action.

PMID- 29828576
TI  - Effect of Higher Education on Salaries.

PMID- 29828577
TI  - Our Hospitals' Christmas, 1918.

PMID- 29828578
TI  - The London Hospital Nurses.

PMID- 29828580
TI  - Round the Hospitals.

PMID- 29828579
TI  - The Editor's Letter-Box.

PMID- 29828582
TI  - Six Years of Panel Practice: Advantages, Disadvantages, and the Remedies.

PMID- 29828581
TI  - Wake up, College of Nursing! Further Signs of Awakening.

PMID- 29828583
TI  - Report of the Distribution Committee.

PMID- 29828584
TI  - The Coming of Age of the Fund.-A Distribution of L200,000.

PMID- 29828585
TI  - Grants to Hospitals Recommended by the Distribution Committee.

PMID- 29828587
TI  - Night Duty and the Patient's Sufferings Increasing Terrors of Each Night.

PMID- 29828586
TI  - Reconstruction and the Voluntary Hospitals.

PMID- 29828589
TI  - Round the Hospitals.

PMID- 29828588
TI  - Overworked and Underpaid Hospital Nurses.

PMID- 29828591
TI  - Hospitals under 50 Beds.

PMID- 29828590
TI  - General Charities.

PMID- 29828592
TI  - Grants Recommended by the Convalescent Homes Committee.

PMID- 29828593
TI  - Flying Machines and Flying Men.

PMID- 29828595
TI  - Hospitals with 150 Beds and Upwards.

PMID- 29828594
TI  - "Ierne"-An Appreciation.

PMID- 29828596
TI  - Should the Nurse Articulate?

PMID- 29828597
TI  - Hospitals under 150 Beds.

PMID- 29828598
TI  - Nurse-Training in Small Hospitals.

PMID- 29828600
TI  - Scottish Nurses in London.

PMID- 29828599
TI  - Report of the Convalescent Homes Committee.

PMID- 29828601
TI  - Hospital and Institutional News.

PMID- 29828602
TI  - Medicinal Preparations and Substitutes.

PMID- 29828603
TI  - Important Developments Foreshadowed.

PMID- 29828604
TI  - The Coming Elections.

PMID- 29828605
TI  - The Percentage of Militarily Inefficients.

PMID- 29828606
TI  - The Hygiene of Modern Armies in the Field.

PMID- 29828607
TI  - Vocation or Profession?

PMID- 29828608
TI  - Appeals.

PMID- 29828609
TI  - An Evil Which Must Be Ended: A Colonial Experience.

PMID- 29828610
TI  - The Gift of Sleep.

PMID- 29828611
TI  - Round the Hospitals.

PMID- 29828612
TI  - Hospital and Institutional News.

PMID- 29828613
TI  - The Popular and Medical Uses of Narcotics.

PMID- 29828614
TI  - Articles on Hospital Construction.

PMID- 29828615
TI  - Where Night Torments for Patients Are Absent.

PMID- 29828616
TI  - Medical Research; American Red Cross Commission's Report.

PMID- 29828617
TI  - A Medical Fellowship.

PMID- 29828618
TI  - Eightieth Anniversary Birthday Gift.

PMID- 29828619
TI  - The Nursing Service in the Dawn of Peace.

PMID- 29828620
TI  - The Reception of the Armistice.

PMID- 29828622
TI  - Qualifications and Administrators.

PMID- 29828621
TI  - The Clare Hall Sanatorium Inquiry: Result.

PMID- 29828623
TI  - Hospital and Institutional News.

PMID- 29828624
TI  - Welfare Work in Factories.

PMID- 29828626
TI  - The Annual Statistical Return.

PMID- 29828625
TI  - Australian Notes.

PMID- 29828627
TI  - Nursing Services of the Crown.

PMID- 29828629
TI  - The Art of Endowment.

PMID- 29828628
TI  - The Repatriation of the Serbians.

PMID- 29828630
TI  - Parliament and the Professions.

PMID- 29828631
TI  - Military versus Medical Titles.

PMID- 29828633
TI  - A Vision of State Medical Service.

PMID- 29828632
TI  - A Remarkable Forecast.

PMID- 29828635
TI  - The Nation's Million for Nurses.

PMID- 29828634
TI  - The Champions of Silence.

PMID- 29828636
TI  - Round the Hospitals.

PMID- 29828637
TI  - Influences of War on Medical Practice.

PMID- 29828638
TI  - Should Diseases Be Named by Their Discoverers?

PMID- 29828639
TI  - "Is Every Woman a Nurse"?

PMID- 29828640
TI  - Round the Hospitals.

PMID- 29828641
TI  - Hospital and Institutional News.

PMID- 29828643
TI  - Order of the British Empire.

PMID- 29828642
TI  - Why Not Every Trained Nurse Awake and Active?

PMID- 29828644
TI  - Discharged Officers and Their Outlook.

PMID- 29828645
TI  - The Hygienic Criterion of Air; Its Capacity for Drying the Skin.

PMID- 29828646
TI  - The Advancement of Medicine by Research.

PMID- 29828647
TI  - A Vision of State Medical Service.

PMID- 29828648
TI  - The Study of Industrial Fatigue.

PMID- 29828649
TI  - An Evil Which Must Be Ended: Night Duty Torments for Patients.

PMID- 29828651
TI  - Cancer of the Tongue and Tobacco.

PMID- 29828650
TI  - Curiosities of Native Treatment in Fiji.

PMID- 29828652
TI  - The Prophylactic Value of Protective Injections.

PMID- 29828653
TI  - Night Sister.

PMID- 29828654
TI  - Many Health Visitors Untrained.

PMID- 29828655
TI  - A Mile-Stone on the Road to Registration.

PMID- 29828656
TI  - Tobacco and Clear Thinking.

PMID- 29828657
TI  - Village Life and Industries: A London Show.

PMID- 29828658
TI  - Relative Virulence of the New Wave.

PMID- 29828659
TI  - Nursing Homes: Criticism with Suggestions.

PMID- 29828660
TI  - War Demobilisation: Payments for Nurses.

PMID- 29828661
TI  - The Case of the Children's Hospitals.

PMID- 29828662
TI  - Politeness to Patients.

PMID- 29828664
TI  - Tethelin.

PMID- 29828663
TI  - Is Nursing a Profession?

PMID- 29828665
TI  - Woolwich Death-Rate Lowest.

PMID- 29828666
TI  - Hospital and Institutional News.

PMID- 29828668
TI  - A Children's Nurse's View of Registration.

PMID- 29828667
TI  - Industrial Hygiene: Factory Nursing.

PMID- 29828669
TI  - The Wassermann Reaction: Simple Aspects of Its Application and Reliability.

PMID- 29828670
TI  - Londoners' Hospital Beds Threatened.

PMID- 29828671
TI  - Some Records at Warrington.

PMID- 29828672
TI  - Round the Hospitals.

PMID- 29828674
TI  - From across the Seas.

PMID- 29828673
TI  - Their Functions and Limitations.

PMID- 29828675
TI  - More Hospital Beds for Civilian Patients?

PMID- 29828676
TI  - Things Doing and to Be Done.

PMID- 29828677
TI  - College Nurses and the Bill.

PMID- 29828678
TI  - The Case of the Children's Hospitals.

PMID- 29828680
TI  - A Preliminary Reform Only.

PMID- 29828681
TI  - A Great Matron's Personality: Thirty-Nine Years' Matronship.

PMID- 29828679
TI  - The Somme: January 1919.

PMID- 29828682
TI  - Curiosities of Native Treatment in Fiji: III. Native Surgery, Pain-Bearing
      Capacity and Customs.

PMID- 29828683
TI  - Is Nursing a Profession? Some Obvious Omissions.

PMID- 29828684
TI  - Points for Members of Parliament.

PMID- 29828685
TI  - Hospital and Institutional News.

PMID- 29828686
TI  - Expectations and Disappointments: The War and the Strikes.

PMID- 29828687
TI  - Round the Hospitals.

PMID- 29828689
TI  - Scopolamine-Morphine Narcosis in Childbirth.

PMID- 29828688
TI  - On Results during 1917 and 1918.

PMID- 29828690
TI  - The Ghoul Type of Nurse.

PMID- 29828691
TI  - Visiting Committee's Proposals for a Central Body for Discussion.

PMID- 29828692
TI  - Co-Operative Appeals.

PMID- 29828693
TI  - Great Achievements Accomplished.

PMID- 29828694
TI  - Self-Help for the General Practitioner.

PMID- 29828695
TI  - A New State Medical Service Plan.

PMID- 29828697
TI  - The First, Though Belated, Account of past Dangers.

PMID- 29828696
TI  - Public Money and Research.

PMID- 29828698
TI  - American War Nurses.

PMID- 29828699
TI  - The College Bill Fully Discussed.

PMID- 29828700
TI  - Two False Statements.

PMID- 29828702
TI  - The Effect of Higher Education on Probationers' Salaries.

PMID- 29828701
TI  - The Efficient Matron Who Creates Happiness.

PMID- 29828703
TI  - Hospital and Institutional News.

PMID- 29828704
TI  - Round the Hospitals.

PMID- 29828705
TI  - Wake up! Messrs. Walter Long and Winston Churchill.

PMID- 29828706
TI  - Round the Hospitals.

PMID- 29828707
TI  - From across the Seas.

PMID- 29828708
TI  - One of the Successes of the War.

PMID- 29828709
TI  - Hospital and Institutional News.

PMID- 29828710
TI  - The Enfield Cottage Hospital Scandal.

PMID- 29828711
TI  - Parliament and the Professions.

PMID- 29828712
TI  - The Next Step.

PMID- 29828713
TI  - An Indian Mission and "The Hospital."

PMID- 29828714
TI  - The Dublin Meeting: The Menace of Trades Unionism.

PMID- 29828715
TI  - Action by the Great Hospitals.

PMID- 29828716
TI  - Proposed New Club for Nurses.

PMID- 29828717
TI  - A Public Duty to Practitioners.

PMID- 29828718
TI  - Is Nursing a Profession: Students or Probationers?

PMID- 29828720
TI  - The Cultivation of Reticence.

PMID- 29828719
TI  - The Research Committee's Future.

PMID- 29828722
TI  - Medicine and the Individual.

PMID- 29828721
TI  - The Meaning of "Efficiency."

PMID- 29828723
TI  - Rats and Mice as Enemies of Mankind.

PMID- 29828724
TI  - A Ship's Dark Hours: Coaling.

PMID- 29828725
TI  - Venereal Cases in General Institutions. A Public Danger?

PMID- 29828726
TI  - Nurses without a Voice.

PMID- 29828727
TI  - Legal Notes for Institutional Workers.

PMID- 29828728
TI  - Tetanus and Its Treatment: A War-Time Retrospect.

PMID- 29828729
TI  - Parliament and the Profession.

PMID- 29828731
TI  - The British Warrior as He Is To-Day.

PMID- 29828730
TI  - Curiosities of Native Treatment in Fiji.

PMID- 29828732
TI  - Hospital Annual Meetings.

PMID- 29828733
TI  - Round the Hospitals.

PMID- 29828734
TI  - The London's Experiment with Paid Doctors.

PMID- 29828735
TI  - The Factory Nurse's Salary.

PMID- 29828737
TI  - Embodying a Part-Time State Medical Service and State Insurance Scheme.

PMID- 29828736
TI  - Ierne Propounds Causes and a Remedy.

PMID- 29828738
TI  - Hospital and Institutional News.

PMID- 29828739
TI  - The Demobilised Doctor.

PMID- 29828740
TI  - Health and Advertised Remedies.

PMID- 29828741
TI  - School Nursing.

PMID- 29828743
TI  - Articles on Hospital Construction.

PMID- 29828742
TI  - The Struggle to Rise.

PMID- 29828744
TI  - The Effects of Indulgence in Alcohol.

PMID- 29828745
TI  - Curiosities of Native Treatment in Fiji.

PMID- 29828746
TI  - Hospital and Institutional News.

PMID- 29828747
TI  - A "Sick House" for Private Nurses.

PMID- 29828748
TI  - The Reproach of Nurses' Poor Pay.

PMID- 29828750
TI  - Some Necessary Qualifications.

PMID- 29828749
TI  - Grave Injustices to Medical Men.

PMID- 29828752
TI  - Hospital Night Nursing; Anxious to Enjoy a Modern Improved System.

PMID- 29828751
TI  - The Case of the Children's Hospitals.

PMID- 29828753
TI  - The Prize Papers.

PMID- 29828754
TI  - The Wigmore Hall Medical Meeting: A Lively Discussion.

PMID- 29828755
TI  - Round the Hospitals.

PMID- 29828756
TI  - Cinderella: Attacking the Servant Problem.

PMID- 29828757
TI  - Filter-Passing Virus in Disease.

PMID- 29828759
TI  - The Wrong Spirit.

PMID- 29828758
TI  - The Health of the Nation: The Essential Food to Maintain Health.

PMID- 29828760
TI  - The Medical Parliamentary Committee.

PMID- 29828761
TI  - The Meeting in Wigmore Hall, London.

PMID- 29828762
TI  - Two Generations of Lunacy Legislation: Its Absurdities and Reform.

PMID- 29828763
TI  - Round the Hospitals.

PMID- 29828764
TI  - Venereal Clinics in U.S.A.: The Value of State Control.

PMID- 29828765
TI  - Memorial Service to the Late Miss Luckes.

PMID- 29828766
TI  - Conciliation or Palliation?

PMID- 29828767
TI  - The Exclusive Title of Nursing Sister.

PMID- 29828768
TI  - Early Diagnosis of Syphilis: The Means in Practitioners' Hands.

PMID- 29828769
TI  - Restrictions on the Sale of Poisonous Drugs: How the Law Stands.

PMID- 29828770
TI  - Articles on Hospital Construction.

PMID- 29828771
TI  - The Ministry of Health Bill.

PMID- 29828772
TI  - Hospital and Institutional News.

PMID- 29828773
TI  - Trade Unionism and the Medical Profession.

PMID- 29828774
TI  - Religion and the Housing Question.

PMID- 29828775
TI  - Registration for Children's Trained Nurses: A Matron's View.

PMID- 29828776
TI  - More Ethics of Controversy.

PMID- 29828777
TI  - Influenza: The Latest Memorandum.

PMID- 29828778
TI  - R.B.N.A. Secretary's Preference for Many Words and Small Type.

PMID- 29828779
TI  - L150,000 Required.

PMID- 29828780
TI  - The College's Attitude to the Bill.

PMID- 29828781
TI  - Bringing the Training Schools into Line.

PMID- 29828782
TI  - Royal Chest Hospital.

PMID- 29828784
TI  - State Registration of Trained Nurses.

PMID- 29828783
TI  - Cutaneous Tuberculosis: A Review of Modern Treatment.

PMID- 29828785
TI  - The Work of the Factory Nurse.

PMID- 29828786
TI  - Consumption in Miners.

PMID- 29828787
TI  - Nerve-Strain and Heredity.

PMID- 29828788
TI  - Round the Hospitals.

PMID- 29828789
TI  - Parliament and the Professions.

PMID- 29828790
TI  - The Control of a Hospital.

PMID- 29828791
TI  - Electricity and Medicine.

PMID- 29828792
TI  - The Hermit Crab.

PMID- 29828793
TI  - Accommodation for Paying Patients.

PMID- 29828794
TI  - Hospital and Institutional News.

PMID- 29828795
TI  - The Reconstruction of Probation.

PMID- 29828796
TI  - Shell-Shock and Suggestion Treatment.

PMID- 29828798
TI  - The Glories of the Profession and Non-Combatants.

PMID- 29828797
TI  - Personal Experiences on the Macedonian Front.

PMID- 29828799
TI  - Hospital Annual Meeting.

PMID- 29828800
TI  - Floor Surfaces.

PMID- 29828801
TI  - On Reading in Bed.

PMID- 29828802
TI  - Parliamentary Report on the Dentists Act.

PMID- 29828803
TI  - The Dublin Meeting: "Facts Turned into Virtual Falsehoods"?

PMID- 29828804
TI  - Hospital and Institutional News.

PMID- 29828805
TI  - The Factory Nurse's Salary.

PMID- 29828806
TI  - Round the Hospitals.

PMID- 29828807
TI  - Our Duty to Our Fellow Workers.

PMID- 29828808
TI  - Parliament and the Profession.

PMID- 29828809
TI  - Gift of a New Tropical Diseases Hospital for London.

PMID- 29828811
TI  - Health in War Industries.

PMID- 29828810
TI  - The Position of Nurses in Great Britain: Is the Government Partially Responsible?

PMID- 29828812
TI  - A League of Public Health Nurses.

PMID- 29828813
TI  - Public Health Report.

PMID- 29828814
TI  - Moral or Legal Responsibility?

PMID- 29828815
TI  - "Do-Nothings" and the College. A Striking Condemnation of Tactics.

PMID- 29828816
TI  - The Problem of Influenza.

PMID- 29828817
TI  - The Cult of the Ugly: Let Parents and Teachers Beware.

PMID- 29828818
TI  - Is Nursing a Profession?

PMID- 29828819
TI  - Nurses in Combination.

PMID- 29828820
TI  - The Approaching End of Boards of Guardians.

PMID- 29828821
TI  - The Right Road to Reform.

PMID- 29828822
TI  - A Plea for Caesarian Section: Its Popularity and Justification.

PMID- 29828823
TI  - Masks: What They Can and Cannot Do.

PMID- 29828824
TI  - Construction Notes.

PMID- 29828825
TI  - "The Hospital" Nursing Mirror.

PMID- 29828826
TI  - Progress in Medicine.

PMID- 29828829
TI  - A Half-Century Cholera Controversy.

PMID- 29828827
TI  - Sanitary Officers and the Law.

PMID- 29828830
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29828831
TI  - New Appliances and Things Medical.

PMID- 29828832
TI  - Annotations.

PMID- 29828833
TI  - Criminal Mania: IV. Illustrative Cases.

PMID- 29828834
TI  - Progress in Surgery.

PMID- 29828835
TI  - Well-Marked and Severe Chicken Pox Occurring in an Adult Pregnant Woman.

PMID- 29828836
TI  - The Central Hospitals Board Question.

PMID- 29828837
TI  - The Hospitals Association.

PMID- 29828838
TI  - Notes and News.

PMID- 29828839
TI  - Construction Notes.

PMID- 29828841
TI  - Progress in Surgery.

PMID- 29828840
TI  - Qualifying for Practice.

PMID- 29828843
TI  - Progress in Medicine.

PMID- 29828842
TI  - A Central Hospital Board for London.

PMID- 29828844
TI  - Annotations.

PMID- 29828845
TI  - New Appliances and Things Medical.

PMID- 29828847
TI  - Practical Departments.

PMID- 29828846
TI  - Professional Advertising.

PMID- 29828848
TI  - The Volunteer Medical Staff Corps at Walmer.

PMID- 29828850
TI  - Notes and News.

PMID- 29828851
TI  - A Sanitary Shibboleth.-Small-Pox Infection.

PMID- 29828852
TI  - Clinical Lecture on Pneumothorax: II. Symptoms of Pneumothorax.

PMID- 29828853
TI  - Criminal Mania: II. The Plea of Insanity.

PMID- 29828854
TI  - "The Hospital" Nursing Mirror.

PMID- 29828855
TI  - Dipththeria Antitoxin.

PMID- 29828856
TI  - Progress in Medicine.

PMID- 29828858
TI  - "The Hospital" Nursing Mirror.

PMID- 29828857
TI  - Kitson versus Playfair.

PMID- 29828859
TI  - Hospital Meetings.

PMID- 29828860
TI  - The Physiological Cost of the Boat-Race.

PMID- 29828861
TI  - The Life and Death of Jewish Babies.

PMID- 29828862
TI  - Notes and News.

PMID- 29828863
TI  - Special Departments at Small Hospitals.

PMID- 29828865
TI  - Annotations.

PMID- 29828864
TI  - The Treatment of Acquired Flat-Foot.

PMID- 29828867
TI  - Progress in Surgery.

PMID- 29828868
TI  - New Appliances and Things Medical.

PMID- 29828869
TI  - Carbohydrate Starvation in Typhoid Fever.

PMID- 29828870
TI  - The Central Hospitals Board.

PMID- 29828871
TI  - Progress in Medicine.

PMID- 29828872
TI  - The New Theology and the New Medicine.

PMID- 29828873
TI  - Progress in Surgery.

PMID- 29828875
TI  - Marriage by Doctor's Consent.

PMID- 29828874
TI  - Suicidal and Dangerous Impulses in Insanity.

PMID- 29828876
TI  - Clipping the Wings of the Midwives.

PMID- 29828877
TI  - "The Hospital" Nursing Mirror.

PMID- 29828878
TI  - New Appliances and Things Medical.

PMID- 29828879
TI  - Notes and News.

PMID- 29828881
TI  - Hospital Meetings.

PMID- 29828880
TI  - Annotations.

PMID- 29828883
TI  - "The Hospital" Nursing Mirror.

PMID- 29828882
TI  - Within the Hospitals.

PMID- 29828884
TI  - On the Treatment of Femoral Hernia.

PMID- 29828886
TI  - Notes and News.

PMID- 29828885
TI  - Clinical Lecture on Pneumothorax: I. The Causes of Pneumothorax.

PMID- 29828887
TI  - New Appliances and Things Medical.

PMID- 29828891
TI  - Street Collections.

PMID- 29828889
TI  - Annotations.

PMID- 29828890
TI  - The Hospital.

PMID- 29828894
TI  - The Place of "The Hospital" in Medical Journalism.

PMID- 29828888
TI  - Construction Notes.

PMID- 29828893
TI  - Progress in Surgery.

PMID- 29828892
TI  - Practical Departments.

PMID- 29828895
TI  - Criminal Mania: I. Elastic Theories.

PMID- 29828897
TI  - The Physiological Cost of the Boat-Race.

PMID- 29828896
TI  - Progress in Medicine.

PMID- 29828898
TI  - The Report on Diphtheria Antitoxin.

PMID- 29828899
TI  - Hospital Meetings.

PMID- 29828900
TI  - Clinical Lecture on Pneumothorax: III. Physical Signs of Pneumothorax.

PMID- 29828902
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29828901
TI  - Hospital Administration.

PMID- 29828903
TI  - New Appliances and Things Medical.

PMID- 29828904
TI  - Hospital Meetings.

PMID- 29828905
TI  - Annotations.

PMID- 29828906
TI  - "The Hospital" Nursing Mirror.

PMID- 29828907
TI  - Hospital Construction.

PMID- 29828908
TI  - Progress in Surgery.

PMID- 29828909
TI  - Construction Notes.

PMID- 29828910
TI  - Why Hospital Patients Complain.

PMID- 29828911
TI  - The Water Supply of Small Towns.

PMID- 29828912
TI  - The Leucocyte in Disease.-II.

PMID- 29828913
TI  - Progress in Medicine.

PMID- 29828914
TI  - Criminal Mania: III. The Doctor's Difficulty.

PMID- 29828915
TI  - Notes and News.

PMID- 29828916
TI  - Tuberculous Milk: Report of the Royal Commission.

PMID- 29828917
TI  - The Examination of Medical Students.

PMID- 29828918
TI  - Progress in Gynaecology.

PMID- 29828919
TI  - Progress in Surgery.

PMID- 29828921
TI  - Annotations.

PMID- 29828920
TI  - Capital Punishment.

PMID- 29828923
TI  - "The Hospital" Nursing Mirror.

PMID- 29828924
TI  - Notes and News.

PMID- 29828922
TI  - Notes on the Treatment of Bronchitis.

PMID- 29828926
TI  - The Medical Care of Children in Durham.

PMID- 29828925
TI  - Guy's Hospital.

PMID- 29828927
TI  - New Appliances and Things Medical.

PMID- 29828928
TI  - "The Hospital" Nursing Mirror.

PMID- 29828929
TI  - Progress in Surgery.

PMID- 29828930
TI  - Prison Labour.

PMID- 29828931
TI  - Jenner: A Hundred Years after.

PMID- 29828932
TI  - The Vaccination Question.

PMID- 29828933
TI  - Clinical Recollections: III. The Alcoholic Habit.

PMID- 29828934
TI  - Annotations.

PMID- 29828935
TI  - Picric Acid in the Treatment of Burns.

PMID- 29828936
TI  - The Future of Vaccination.

PMID- 29828937
TI  - Progress in Medicine.

PMID- 29828938
TI  - The Comparative Nutrient Value of Meat Preparations.

PMID- 29828939
TI  - The Central Hospitals Board.

PMID- 29828940
TI  - Notes and News.

PMID- 29828941
TI  - Hospital Meetings.

PMID- 29828943
TI  - The Breaking Strain.

PMID- 29828945
TI  - "The Hospital" Nursing Mirror.

PMID- 29828944
TI  - Joint Action against Small-Pox.

PMID- 29828946
TI  - The Jenner Society.

PMID- 29828948
TI  - Hospital Meetings.

PMID- 29828949
TI  - Notes and News.

PMID- 29828950
TI  - The Story of the Insane from Year to Year.

PMID- 29828952
TI  - Progress in Surgery.

PMID- 29828951
TI  - The Pathology of Appendicitis.

PMID- 29828953
TI  - Hospital Construction.

PMID- 29828954
TI  - Annotations.

PMID- 29828955
TI  - Oysters and Typhoid: Proposed Legislation.

PMID- 29828956
TI  - The Progress of Cremation in America.

PMID- 29828958
TI  - Progress in Medicine.

PMID- 29828957
TI  - The Central Hospitals Board.

PMID- 29828961
TI  - Progress in Medicine.

PMID- 29828959
TI  - New Appliances and Things Medical.

PMID- 29828962
TI  - Diet for Schoolboys: II. The Question of Meals and Food.

PMID- 29828963
TI  - Metropolitan Hospital Sunday Fund, 1896.

PMID- 29828964
TI  - Progress in Surgery.

PMID- 29828965
TI  - Hospital Meetings.

PMID- 29828966
TI  - Annotations.

PMID- 29828967
TI  - The Election of Direct Representatives.

PMID- 29828968
TI  - New Appliances and Things Medical.

PMID- 29828969
TI  - The Prevention of Colliery Explosions.

PMID- 29828970
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29828971
TI  - Notes and News.

PMID- 29828973
TI  - "The Hospital" Nursing Mirror.

PMID- 29828972
TI  - Alcoholic Stimulation.

PMID- 29828974
TI  - The London University.

PMID- 29828975
TI  - Progress in Medicine.

PMID- 29828976
TI  - Notes and News.

PMID- 29828977
TI  - The Voice of Medical Science at Pretoria.

PMID- 29828979
TI  - "The Hospital" Nursing Mirror.

PMID- 29828978
TI  - Notes on the Treatment of Bronchitis.

PMID- 29828980
TI  - New Appliances and Things Medical.

PMID- 29828981
TI  - Progress in Surgery.

PMID- 29828983
TI  - The Central Hospitals Board.

PMID- 29828984
TI  - Hospital Meetings.

PMID- 29828985
TI  - The Pathology of Appendicitis.

PMID- 29828986
TI  - Prison Labour: Observations of the Prison Commissioners on the Recommendation of
      the Departmental Committee on Prisons Appointed by the Secretary of State on June
      6, 1894.

PMID- 29828987
TI  - Annotations.

PMID- 29828988
TI  - Notes and News.

PMID- 29828989
TI  - The Early Diagnosis of Bright's Disease.

PMID- 29828990
TI  - Case of Purpura Haemorrhagica Following "Malta" or "Mediterranean" Fever.

PMID- 29828991
TI  - Sewage Farming and Sanitation.

PMID- 29828992
TI  - Practical Departments.

PMID- 29828993
TI  - The Story of the Insane from Year to Year.

PMID- 29828994
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29828995
TI  - Progress in Surgery.

PMID- 29828996
TI  - Hospital Construction.

PMID- 29828997
TI  - Hospital Meetings.

PMID- 29828998
TI  - New Appliances and Things Medical.

PMID- 29829000
TI  - Home Industry and the Sweating System.

PMID- 29828999
TI  - Asthma.

PMID- 29829001
TI  - Progress in Medicine.

PMID- 29829003
TI  - Annotations.

PMID- 29829004
TI  - Some Prolegomena to a Philosophy of Medicine.

PMID- 29829005
TI  - "The Hospital" Nursing Mirror.

PMID- 29829006
TI  - Hospital Meetings.

PMID- 29829007
TI  - The Children of the State.

PMID- 29829008
TI  - New Appliances and Things Medical.

PMID- 29829009
TI  - Annotations.

PMID- 29829011
TI  - Notes and News.

PMID- 29829012
TI  - The Municipal Control of Measles.

PMID- 29829010
TI  - Progress in Surgery.

PMID- 29829013
TI  - Lady Warwick's Home for Crippled Children.

PMID- 29829014
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829015
TI  - Should English Doctors Dispense?

PMID- 29829016
TI  - Progress in Medicine.

PMID- 29829017
TI  - Latent Squint.

PMID- 29829019
TI  - Construction Notes.

PMID- 29829018
TI  - The Story of the Insane from Year to Year.

PMID- 29829022
TI  - The Nature and Surgical Treatment of Tumours of the Spinal Cord.

PMID- 29829021
TI  - "The Hospital" Nursing Mirror.

PMID- 29829023
TI  - Notes and News.

PMID- 29829024
TI  - Street Collections.

PMID- 29829026
TI  - Practical Departments.

PMID- 29829025
TI  - Hospital Construction: Mechanical Ventilation of Hospital Wards.

PMID- 29829027
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829029
TI  - Sea Travel without Sea Sickness.

PMID- 29829031
TI  - Annotations.

PMID- 29829030
TI  - "The Hospital" Nursing Mirror.

PMID- 29829033
TI  - The Battle of the Clubs.

PMID- 29829032
TI  - Progress in Medicine.

PMID- 29829034
TI  - Construction Notes.

PMID- 29829035
TI  - Progress in Otology.

PMID- 29829036
TI  - Tumours of the Groin and Their Differential Diagnosis.

PMID- 29829038
TI  - "The Hospital" Nursing Mirror.

PMID- 29829037
TI  - Hospitals in India.

PMID- 29829039
TI  - Annotations.

PMID- 29829040
TI  - Construction Notes.

PMID- 29829042
TI  - Practical Departments.

PMID- 29829041
TI  - Disinfection by the Vapour of Formaldehyde.

PMID- 29829044
TI  - The Eyesight of School Children.

PMID- 29829043
TI  - The British Medical Association and Medical Defence.

PMID- 29829045
TI  - Notes and News.

PMID- 29829046
TI  - New Appliances and Things Medical.

PMID- 29829047
TI  - The Diet of Schoolboys: I. Introductory.

PMID- 29829048
TI  - Progress in Medicine.

PMID- 29829050
TI  - Progress in Surgery.

PMID- 29829049
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829051
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829052
TI  - A Dispensary Clinic.-Cancer of the Rectum.

PMID- 29829054
TI  - The Medical Attitude Towards Compulsory Vaccination.

PMID- 29829053
TI  - Construction Notes.

PMID- 29829056
TI  - Notes and News.

PMID- 29829055
TI  - Annotations.

PMID- 29829058
TI  - Progress in Medicine.

PMID- 29829057
TI  - New Appliances and Things Medical.

PMID- 29829059
TI  - "The Hospital" Nursing Mirror.

PMID- 29829060
TI  - Classification in Workhouses.-How to Make It Effective.

PMID- 29829061
TI  - Hospital Construction.

PMID- 29829062
TI  - Students and Maternity Departments.

PMID- 29829063
TI  - Progress in Surgery.

PMID- 29829064
TI  - Hospital Administration: Provision for Incurables.

PMID- 29829065
TI  - Construction Notes.

PMID- 29829066
TI  - Annotations.

PMID- 29829067
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829068
TI  - Around the Hospitals.

PMID- 29829069
TI  - The Notification of Tuberculosis.

PMID- 29829070
TI  - The Story of the Insane from Year to Year.

PMID- 29829071
TI  - "The Hospital" Nursing Mirror.

PMID- 29829072
TI  - Juvenile Crime.

PMID- 29829073
TI  - The Treatment of Ulcers, Wounds, and Other Surgical Cases by Oxygen.

PMID- 29829074
TI  - Tumours of the Groin and Their Differential Diagnosis.

PMID- 29829075
TI  - Progress in Otology.

PMID- 29829076
TI  - The British Medical Association and Their Midwives Bills.

PMID- 29829078
TI  - Notes and News.

PMID- 29829077
TI  - New Appliances and Things Medical.

PMID- 29829079
TI  - Progress in Surgery.

PMID- 29829080
TI  - Hospital Meetings.

PMID- 29829082
TI  - Progress in Surgery.

PMID- 29829081
TI  - Construction Notes.

PMID- 29829083
TI  - New Appliances and Things Medical.

PMID- 29829085
TI  - Notes and News.

PMID- 29829086
TI  - Progress in Medicine.

PMID- 29829087
TI  - Annotations.

PMID- 29829088
TI  - The Young Ravens of Physic.

PMID- 29829089
TI  - Progress in Dermatology.

PMID- 29829090
TI  - Some Byeways of Practice.

PMID- 29829091
TI  - Disinfection of Rooms by Formaldehyde Vapour.

PMID- 29829092
TI  - "The Hospital" Nursing Mirror.

PMID- 29829093
TI  - The Evolution of the Modern Hospital: II. The Latest Hospital.

PMID- 29829094
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829095
TI  - Hospital Construction.

PMID- 29829096
TI  - The Story of the Insane from Year to Year.

PMID- 29829097
TI  - Progress in Medicine.

PMID- 29829099
TI  - Progress in Surgery.

PMID- 29829100
TI  - "The Hospital" Nursing Mirror.

PMID- 29829101
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829103
TI  - The Evolution of the Modern Hospital: III. Its Benefits and Lessons.

PMID- 29829102
TI  - Various Wounds of Various Joints at Torbay Hospital, Torquay.

PMID- 29829105
TI  - Compulsory Re-Vaccination.

PMID- 29829104
TI  - Annotations.

PMID- 29829107
TI  - Alcoholic Stimulation.

PMID- 29829106
TI  - The Early Diagnosis of Small-Pox.

PMID- 29829108
TI  - Notes and News.

PMID- 29829109
TI  - Practical Departments.

PMID- 29829110
TI  - Hydronephrosis: Its Causes, Diagnosis, and Treatment.

PMID- 29829111
TI  - Doctors and Midwives.

PMID- 29829112
TI  - The Story of the Insane from Year to Year.

PMID- 29829113
TI  - Notes and News.

PMID- 29829114
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829115
TI  - "The Hospital" Nursing Mirror.

PMID- 29829116
TI  - Annotations.

PMID- 29829117
TI  - The Evolution of the Modern Hospital: I. The Growth of the Hospital Idea.

PMID- 29829118
TI  - Sir Dyce Duckworth on Prognosis.

PMID- 29829119
TI  - Progress in Dermatology.

PMID- 29829120
TI  - Practical Points.

PMID- 29829121
TI  - Hospital Meetings.

PMID- 29829122
TI  - Progress in Surgery.

PMID- 29829123
TI  - Professional Advertising.

PMID- 29829124
TI  - New Appliances and Things Medical.

PMID- 29829126
TI  - The Story of the Insane from Year to Year.

PMID- 29829125
TI  - On Cancer of the Tongue.

PMID- 29829127
TI  - Charity, Capacity, Continuity.

PMID- 29829128
TI  - The Foundations of Modern Sociology.

PMID- 29829129
TI  - Progress in Surgery.

PMID- 29829130
TI  - Special Hospital Sunday Supplement.

PMID- 29829131
TI  - Around the Hospitals.

PMID- 29829132
TI  - New Appliances and Things Medical.

PMID- 29829134
TI  - Hospital Meetings.

PMID- 29829133
TI  - Asthma.

PMID- 29829135
TI  - Hospital Sunday.

PMID- 29829136
TI  - Notes on the Treatment of Bronchitis.

PMID- 29829137
TI  - "The Hospital" Nursing Mirror.

PMID- 29829138
TI  - Notes and News.

PMID- 29829139
TI  - Progress in Obstetrics.

PMID- 29829140
TI  - Construction Notes.

PMID- 29829141
TI  - Unqualified Practice and the Law.

PMID- 29829142
TI  - Metropolitan Hospital Sunday Fund: Presentation by the Prince of Wales to Mr.
      Burdett.

PMID- 29829143
TI  - Annotations.

PMID- 29829145
TI  - Around the Hospitals.

PMID- 29829144
TI  - The Birmingham Hospital Saturday Fund.

PMID- 29829146
TI  - Hospital Construction.

PMID- 29829147
TI  - Notes and News.

PMID- 29829149
TI  - The Phoenician and Carthaginian Influence.

PMID- 29829148
TI  - The Treatment of Chronic Varicose Ulcers of the Leg.

PMID- 29829150
TI  - Progress in Medicine.

PMID- 29829152
TI  - "The Hospital" Nursing Mirror.

PMID- 29829153
TI  - Sir Joseph Lister's Address.

PMID- 29829154
TI  - Annotations.

PMID- 29829156
TI  - Progress in Surgery.

PMID- 29829155
TI  - New Appliances and Things Medical.

PMID- 29829157
TI  - Homes for the Dying.

PMID- 29829158
TI  - Hospital Ships.

PMID- 29829159
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829160
TI  - Mechanical Ventilation of Hospital Wards.

PMID- 29829161
TI  - Pershore Cottage Hospital.

PMID- 29829162
TI  - Annotations.

PMID- 29829164
TI  - Notes and News.

PMID- 29829163
TI  - Life and the Municipality.

PMID- 29829166
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829165
TI  - Homes for the Dying.

PMID- 29829167
TI  - New Appliances and Things Medical.

PMID- 29829168
TI  - The State of the Streets.

PMID- 29829170
TI  - "The Hospital" Nursing Mirror.

PMID- 29829169
TI  - The Surgical Diseases of the Sub-Maxillary Gland.

PMID- 29829171
TI  - Practical Points.

PMID- 29829172
TI  - Progress in Medicine.

PMID- 29829173
TI  - The Hebrew Influence.

PMID- 29829174
TI  - Progress in Surgery.

PMID- 29829175
TI  - Hospital Meetings.

PMID- 29829176
TI  - The Etiology of Diphtheria.

PMID- 29829177
TI  - Practical Departments.

PMID- 29829178
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829180
TI  - Foreign Hospitals.

PMID- 29829181
TI  - The Treatment of Congenital Club Foot in Infancy.

PMID- 29829182
TI  - Ectopic Gestation.

PMID- 29829184
TI  - A Hospital Saturday Fund in Danger.

PMID- 29829183
TI  - The Story of the Insane from Year to Year.

PMID- 29829185
TI  - Progress in Surgery.

PMID- 29829186
TI  - Annotations.

PMID- 29829188
TI  - Notes and News.

PMID- 29829187
TI  - "The Hospital" Nursing Mirror.

PMID- 29829190
TI  - Is Our Knowledge of Lunacy Stationary?

PMID- 29829189
TI  - Country Holidays for Town Children.

PMID- 29829191
TI  - Progress in Medicine.

PMID- 29829192
TI  - Progress in Surgery.

PMID- 29829193
TI  - The Report of the Royal Commission on Vaccination.

PMID- 29829194
TI  - Penal Servitude and Insanity.

PMID- 29829195
TI  - Notes and News.

PMID- 29829196
TI  - Hospital Construction.

PMID- 29829197
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29829198
TI  - Annotations.

PMID- 29829199
TI  - Medicine as a Science or an Art.

PMID- 29829200
TI  - "The Hospital" Nursing Mirror.

PMID- 29829201
TI  - The Royal Commission on Vaccination.

PMID- 29829202
TI  - New Appliances and Things Medical.

PMID- 29829203
TI  - The Story of the Insane from Year to Year.

PMID- 29829204
TI  - Hospital Meetings.

PMID- 29829206
TI  - The Metropolitan Medical Schools: Medical Study in London.

PMID- 29829205
TI  - Progress in Medicine.

PMID- 29829207
TI  - Medical Schools for Women.

PMID- 29829208
TI  - The Irish Medical Schools: Medical Study in Ireland.

PMID- 29829209
TI  - Practical Departments.

PMID- 29829211
TI  - Hospital Construction.

PMID- 29829212
TI  - Medicine as a Profession.

PMID- 29829213
TI  - Classification in Workhouses: II. What It Might Accomplish.

PMID- 29829215
TI  - The Provincial Medical Schools: Medical Study in the Provinces.

PMID- 29829214
TI  - Construction Notes.

PMID- 29829216
TI  - Annotations.

PMID- 29829217
TI  - From Student to Practitioner.

PMID- 29829218
TI  - "The Hospital" Nursing Mirror.

PMID- 29829219
TI  - Progress in Surgery.

PMID- 29829220
TI  - The Scotch Medical Schools: Medical Study in Scotland.

PMID- 29829221
TI  - The Career of the Medical Student: The Choice of a Qualification.

PMID- 29829222
TI  - Public Health in Ireland.

PMID- 29829223
TI  - How to Attract Suitable Women to the Nursing Profession.

PMID- 29829224
TI  - The General Practitioner and the New Health Bill.

PMID- 29829225
TI  - Women and Nursing.

PMID- 29829226
TI  - Hospital and Institutional News.

PMID- 29829227
TI  - District Nursing.

PMID- 29829228
TI  - Round the Hospitals.

PMID- 29829229
TI  - B.M.A. and the National Scheme.

PMID- 29829230
TI  - Hospital Sites.

PMID- 29829231
TI  - The Thirty-Third Annual Meeting.

PMID- 29829232
TI  - A Review of Interest to Health Workers.

PMID- 29829233
TI  - Should a Doctor Tell?

PMID- 29829234
TI  - Overseas Nursing Association.

PMID- 29829235
TI  - Annual Meeting of Members.

PMID- 29829236
TI  - Medical Fashions.

PMID- 29829237
TI  - Recruiting for the Training-Schools.

PMID- 29829238
TI  - The Reform of Medical Teaching.

PMID- 29829239
TI  - Baby Clinic Experiences.

PMID- 29829240
TI  - Parliament and the Professions.

PMID- 29829241
TI  - The Late Sir Henry Burdett.

PMID- 29829242
TI  - Children's Rights.

PMID- 29829243
TI  - Views of Dr. Addison.

PMID- 29829244
TI  - Parliament and the Professions.

PMID- 29829245
TI  - Institutional Needs.

PMID- 29829246
TI  - The Purpose of Nursery Schools.

PMID- 29829247
TI  - Outlying Sanatoria.

PMID- 29829248
TI  - A Private Nurse's Earnings.

PMID- 29829249
TI  - Hospital and Institutional News.

PMID- 29829251
TI  - More Maternity Hospitals Wanted.

PMID- 29829250
TI  - The Present Scarcity of Nurses.

PMID- 29829252
TI  - A "Model Scheme" in Gloucestershire.

PMID- 29829253
TI  - General Survey of England and Wales.

PMID- 29829254
TI  - A Sketch of a Future Policy.

PMID- 29829255
TI  - Prevention after Cure.

PMID- 29829256
TI  - The "New Hospitals."

PMID- 29829257
TI  - A Novel Scheme of Re-Organisation.

PMID- 29829259
TI  - The Smoke Pall.

PMID- 29829258
TI  - The Conversazione at Burlington House.

PMID- 29829260
TI  - Against Milk Grading.

PMID- 29829261
TI  - Certum Est, Quia Impossibile Est.-Tertullian.

PMID- 29829262
TI  - Round the Hospitals.

PMID- 29829264
TI  - Hospital Annual Meetings.

PMID- 29829263
TI  - A Rejoinder to "A Friendly Cross-Examination."

PMID- 29829266
TI  - Tied Houses in Surgical Practice.

PMID- 29829265
TI  - The Guest Hospital, Dudley.

PMID- 29829268
TI  - Fight against Epidemics.

PMID- 29829267
TI  - Illegitimate Parents.

PMID- 29829269
TI  - Hospital and Institutional News.

PMID- 29829270
TI  - The Late Sir Henry Burdett.

PMID- 29829271
TI  - Some Rare Varieties.

PMID- 29829273
TI  - The New Poor.

PMID- 29829272
TI  - The Position of the Hospital Saturday Fund.

PMID- 29829275
TI  - Home Life.

PMID- 29829274
TI  - Industrial Hygiene.

PMID- 29829276
TI  - A Central Hospital Board for London.

PMID- 29829277
TI  - Clean Milk Advice.

PMID- 29829278
TI  - The Danger of the Dead Tooth.

PMID- 29829279
TI  - A Forty-Eight Hours' Week.

PMID- 29829280
TI  - Suggestions by the Board of Control.

PMID- 29829281
TI  - An Army of 53,000 Always in the Trenches.

PMID- 29829283
TI  - Recent Teaching on Their Surgical Diagnosis and Treatment.

PMID- 29829282
TI  - Massage Establishments.

PMID- 29829284
TI  - The Changed Probationer.

PMID- 29829285
TI  - Round the Hospitals.

PMID- 29829286
TI  - Official Resolutions and Messages.

PMID- 29829287
TI  - A Private Nurse's Earnings.

PMID- 29829288
TI  - A Proposed New Staff of Outdoor Medical Officers.

PMID- 29829289
TI  - A Preliminary Look.

PMID- 29829291
TI  - The Crowded Medical Schools.

PMID- 29829290
TI  - Institutional Training for Pharmacists.

PMID- 29829292
TI  - The Weekly Day off.

PMID- 29829293
TI  - Florence Nightingale.

PMID- 29829294
TI  - Some Interesting Experiments in Physical Efficiency.

PMID- 29829295
TI  - The Holiday Tax.

PMID- 29829297
TI  - Healthy London.

PMID- 29829296
TI  - Parliament and the Professions.

PMID- 29829298
TI  - The Position of St. George's Hospital.

PMID- 29829299
TI  - Health Minister's Statement.

PMID- 29829300
TI  - A Hospital Secretary's View.

PMID- 29829301
TI  - Colonial Hospital Laws.

PMID- 29829302
TI  - General Hospital, Birmingham.

PMID- 29829303
TI  - The Nurse as Health Visitor.

PMID- 29829304
TI  - Smith's Duty to His Neighbour.

PMID- 29829305
TI  - Erratum.
AB  - [This corrects the article on p. 401 in vol. 68.].

PMID- 29829306
TI  - The Ministry of Health.

PMID- 29829307
TI  - Some National Aspects of Transport.

PMID- 29829308
TI  - Hospital Patients' Sick Insurance.

PMID- 29829310
TI  - National Health and Modern Problems.

PMID- 29829309
TI  - The De La Rue Scheme of Medical Service.

PMID- 29829311
TI  - Round the Hospitals.

PMID- 29829312
TI  - St. Mary's Hospital Musical and Dramatic Society.

PMID- 29829313
TI  - The Need for Education.

PMID- 29829314
TI  - Voluntary Insurance by Patients.

PMID- 29829315
TI  - Hospital and Institutional News.

PMID- 29829316
TI  - The Cult of Middle-Age.

PMID- 29829317
TI  - Poor-Law Almoners.

PMID- 29829319
TI  - The Art of Convalescence.

PMID- 29829318
TI  - Venereal Prevention.

PMID- 29829320
TI  - Scheme for Assisting Voluntary Hospitals.

PMID- 29829321
TI  - Teaching the Careless.

PMID- 29829322
TI  - The "Full-Time" Teacher.

PMID- 29829323
TI  - A Friendly Cross-Examination: By a Special Correspondent.

PMID- 29829325
TI  - Payments by Patients.

PMID- 29829324
TI  - Parliament and the Professions.

PMID- 29829326
TI  - The College Election.

PMID- 29829327
TI  - The Successes of the Organised Profession.

PMID- 29829328
TI  - Population and Parenthood.

PMID- 29829329
TI  - Hospital Chaplains to the Rescue.

PMID- 29829330
TI  - Round the Hospitals.

PMID- 29829331
TI  - The Outbreak of Influenza.

PMID- 29829333
TI  - Hospital and Institutional News.

PMID- 29829332
TI  - Progress in the Construction of General Appliances.

PMID- 29829334
TI  - Some Conclusions Drawn at the Manchester Meeting.

PMID- 29829335
TI  - A Royal Appeal.

PMID- 29829336
TI  - Hospital Annual Meetings.

PMID- 29829337
TI  - Tied Houses in Surgical Practice.

PMID- 29829338
TI  - A Remarkable Clinical Test Described.

PMID- 29829339
TI  - Nurse-Training in Special Hospitals.

PMID- 29829341
TI  - A Joint Council for After-War Service.

PMID- 29829340
TI  - Our Defence against Smallpox.

PMID- 29829342
TI  - Professional Dualities.

PMID- 29829343
TI  - The Tuberculosis Congress.

PMID- 29829344
TI  - Leicester Royal Infirmary.

PMID- 29829346
TI  - Some New Uses for X-Rays.

PMID- 29829345
TI  - Industrial Welfare.

PMID- 29829348
TI  - The New Income Tax Rules.

PMID- 29829347
TI  - The Divorce Controversy.

PMID- 29829349
TI  - The Lady Priestley Lecture.

PMID- 29829350
TI  - Cancer Research.

PMID- 29829352
TI  - Boy Labour in Mines.

PMID- 29829351
TI  - The Professional Union of Trained Nurses.

PMID- 29829354
TI  - Hospital and Institutional News.

PMID- 29829353
TI  - Sanatorium Treatment.

PMID- 29829355
TI  - Baby Week.

PMID- 29829356
TI  - The Increased Cost of the Probationer.

PMID- 29829357
TI  - The Budget.

PMID- 29829358
TI  - The Brussels Health Congress.

PMID- 29829360
TI  - Parliament and the Professions.

PMID- 29829359
TI  - A Notable Institution.

PMID- 29829361
TI  - Round the Hospitals.

PMID- 29829362
TI  - University College Hospital and the Royal Ear Hospital.

PMID- 29829363
TI  - An Employee's Industrial Views.

PMID- 29829364
TI  - The Strike of Mine Rescuers.

PMID- 29829365
TI  - Theories and Practice.

PMID- 29829366
TI  - Parenthood, Economics, and Knowledge.

PMID- 29829367
TI  - What the Public Forget.

PMID- 29829369
TI  - Protecting the Children.

PMID- 29829368
TI  - Venereal Disease.

PMID- 29829370
TI  - The City Coroner's Annual Report.

PMID- 29829371
TI  - The College and Nurses' Hours.

PMID- 29829372
TI  - A Recent Lecture.

PMID- 29829373
TI  - A Slashing Document.

PMID- 29829375
TI  - Annual Meetings of Hospitals.

PMID- 29829374
TI  - Birth-Rate and Sex Education.

PMID- 29829376
TI  - Scrapping the Trained Nurse: The Only Alternative.

PMID- 29829377
TI  - The Sanitary Blocks of Hospitals.

PMID- 29829379
TI  - A Cancer Crusade: Many Facts and More Possibilities.

PMID- 29829378
TI  - Round the Hospitals.

PMID- 29829380
TI  - Regulating Employment of Children.

PMID- 29829381
TI  - The District Nurse in the Outer Hebrides.

PMID- 29829383
TI  - Hospital and Institutional News.

PMID- 29829382
TI  - Gun-Shot Wounds of the Jaw and Facial Injuries: II. Some Nursing Aspects.

PMID- 29829384
TI  - Development at Walsall General Hospital.

PMID- 29829385
TI  - Damnable!

PMID- 29829387
TI  - Children's Fears.

PMID- 29829386
TI  - A Factor in Disease Control.

PMID- 29829389
TI  - As Others See Us.

PMID- 29829388
TI  - The Democratic Ideal.

PMID- 29829390
TI  - David Williams, the Queer Philanthropist.

PMID- 29829391
TI  - Corporate Medical Lead.

PMID- 29829393
TI  - The Turning-Point in the Hospital Campaign.

PMID- 29829392
TI  - Changes in the Statistical Report.

PMID- 29829394
TI  - A Debatable Poor-Law Plan.

PMID- 29829395
TI  - Drunkenness Statistics.

PMID- 29829396
TI  - Quack Medicines.

PMID- 29829397
TI  - Abstract of a Noteworthy Presidential Address.

PMID- 29829398
TI  - Round the Hospitals.

PMID- 29829399
TI  - The Father's Responsibilities.

PMID- 29829400
TI  - Sex Hygiene for the Young.

PMID- 29829401
TI  - The Medical Examination of Civilian Airmen.

PMID- 29829402
TI  - The Proprietary Medicines Bill.

PMID- 29829403
TI  - Erratum: A Correction.
AB  - [This corrects the article on p. 343 in vol. 68.].

PMID- 29829404
TI  - Parliament and the Professions.

PMID- 29829405
TI  - National Health and Modern Problems.

PMID- 29829406
TI  - The Dilemma of the Little Hospitals.

PMID- 29829407
TI  - Distribution of L110,000.

PMID- 29829408
TI  - The Stimulus to Growth.

PMID- 29829410
TI  - Hospital and Institutional News.

PMID- 29829409
TI  - The Dilemma at Gravesend.

PMID- 29829411
TI  - The Sunday Fund's Success.

PMID- 29829412
TI  - A Diversion.

PMID- 29829414
TI  - Clean Milk Film.

PMID- 29829413
TI  - Advanced Consumptives.

PMID- 29829416
TI  - A Comparison between Gas and Electricity.

PMID- 29829415
TI  - Child Welfare in India.

PMID- 29829417
TI  - The Value of Vaccination.

PMID- 29829418
TI  - Hospital Annual Meetings.

PMID- 29829419
TI  - The Foolish Recoil from Registration.

PMID- 29829420
TI  - The Administration of Gas and Oxygen.

PMID- 29829422
TI  - The Line to Salonica.

PMID- 29829421
TI  - Smoking in Hospital Wards.

PMID- 29829423
TI  - The Fees of Practitioner and Consultant.

PMID- 29829424
TI  - State Assistance to Voluntary Hospitals. Free Donations from Income- and Super
      Taxes.

PMID- 29829425
TI  - Times of Regeneration.

PMID- 29829426
TI  - Welfare of Workers.

PMID- 29829427
TI  - National Health Week.

PMID- 29829428
TI  - Round the Hospitals.

PMID- 29829430
TI  - A Prevalent Habit Condemned.

PMID- 29829429
TI  - Hospital and Institutional News.

PMID- 29829431
TI  - The Spiritual Side of Nursing.

PMID- 29829432
TI  - Australian News.

PMID- 29829434
TI  - Hospitals and the Honours List.

PMID- 29829433
TI  - Bastardy Laws.

PMID- 29829435
TI  - Medical Research.

PMID- 29829436
TI  - Wage-Earning Children.

PMID- 29829437
TI  - Gun-Shot Wounds of the Jaw and Facial Injuries: Some Nursing Aspects.

PMID- 29829438
TI  - Legal Notes for Institutional Workers.

PMID- 29829440
TI  - Parliament and the Professions.

PMID- 29829439
TI  - Studies in Mental Ineffic Ency.

PMID- 29829442
TI  - A Teeth Conference.

PMID- 29829441
TI  - Medicine's Opportunity.

PMID- 29829443
TI  - Manchester's Milk Supply.

PMID- 29829445
TI  - Life of Social Service.

PMID- 29829444
TI  - Is the Trained Nurse Barred?

PMID- 29829446
TI  - The Fees of Practitioner and Consultant.

PMID- 29829447
TI  - A Recent Meeting at the New York Academy.

PMID- 29829449
TI  - Literature and Public Welfare.

PMID- 29829448
TI  - In Defence of Mothers.

PMID- 29829450
TI  - Institutional Returns for 1919.

PMID- 29829451
TI  - Round the Hospitals.

PMID- 29829452
TI  - War on Disease.

PMID- 29829453
TI  - Hospital Annual Meetings.

PMID- 29829454
TI  - Public Pharmacists' Association.

PMID- 29829455
TI  - Employment of the Disabled.

PMID- 29829456
TI  - Hospital and Institutional News.

PMID- 29829457
TI  - The College of Nursing Badge.

PMID- 29829459
TI  - A Great Wave of Enthusiasm.

PMID- 29829458
TI  - Is It State Aid?

PMID- 29829460
TI  - A University Appeal.

PMID- 29829461
TI  - The Keeping of Personal Records.

PMID- 29829463
TI  - Leicester Royal Infirmary.

PMID- 29829462
TI  - Primary and Cutaneous Lesions in the Male.

PMID- 29829464
TI  - A Stable Vitamine.

PMID- 29829465
TI  - Homes for Mothers.

PMID- 29829467
TI  - The Future of Salisbury Infirmary.

PMID- 29829466
TI  - Sanatorium Figures.

PMID- 29829468
TI  - Hospital and Institutional News.

PMID- 29829469
TI  - Its Utility in the Feeding of Infants.

PMID- 29829470
TI  - Hospitals and a Coal Strike.

PMID- 29829471
TI  - The Gift of Expression.

PMID- 29829473
TI  - Johannesburg Hospital Board's Experiment.

PMID- 29829472
TI  - A New Call for Nurses.

PMID- 29829474
TI  - Asylum War Hospitals.

PMID- 29829475
TI  - Doctors and Sympathy.

PMID- 29829477
TI  - Australian Notes.

PMID- 29829476
TI  - Nursing under the M.A.B.

PMID- 29829478
TI  - Round the Hospitals.

PMID- 29829479
TI  - State Registration and Its Values.

PMID- 29829480
TI  - Royal Devon and Exeter Hospital.

PMID- 29829481
TI  - The Infectious Diseases Reports.

PMID- 29829482
TI  - Incipient Mental Disease.

PMID- 29829483
TI  - The Typhus Danger.

PMID- 29829484
TI  - Dispensaries for Hop-Pickers.

PMID- 29829485
TI  - Domestic Service in Institutions.

PMID- 29829487
TI  - An Announcement by the Ministry of Health.

PMID- 29829486
TI  - The Permanent Memorial.

PMID- 29829488
TI  - Inspections in America and Germany.

PMID- 29829489
TI  - Recollections.

PMID- 29829490
TI  - The Value of Journalism to Hospitals.

PMID- 29829491
TI  - The Housing Campaign.

PMID- 29829492
TI  - Care of Young Invalids.

PMID- 29829494
TI  - Annual Meeting of the President and General Council.

PMID- 29829493
TI  - King Edward's Fund Grants.

PMID- 29829495
TI  - Parliament and the Professions.

PMID- 29829496
TI  - The Departmental Method.

PMID- 29829497
TI  - Last Visit to Hospitals.

PMID- 29829498
TI  - A Visit to the Front.

PMID- 29829499
TI  - Hospital and Institutional News.

PMID- 29829500
TI  - Some Novel Relations in Human Pathology.

PMID- 29829501
TI  - Housing Facts and Fancy.

PMID- 29829502
TI  - Sir Henry Burdett, K.C.B., K.C.V.O. 1847-1920.

PMID- 29829503
TI  - Report of the General Council.

PMID- 29829504
TI  - Crippled Children.

PMID- 29829506
TI  - Appreciations from the Lay Press.

PMID- 29829505
TI  - Mayoral Health Meeting.

PMID- 29829507
TI  - The Years at the Seamen's Hospital.

PMID- 29829508
TI  - The Floral Tributes.

PMID- 29829510
TI  - Parliament and the Professions.

PMID- 29829509
TI  - Round the Hospitals.

PMID- 29829512
TI  - Economics and Motherhood.

PMID- 29829511
TI  - On the Track of a Ward-Maid.

PMID- 29829514
TI  - King in Manchester.

PMID- 29829513
TI  - Mrs. Humphry Ward.

PMID- 29829515
TI  - Leicester Saturday Hospital Society.

PMID- 29829516
TI  - Nursing Conditions in Pay Hospitals.

PMID- 29829518
TI  - Defining the New Poor.

PMID- 29829517
TI  - Cardiac Efficiency: Some Modern Methods of Examination.

PMID- 29829519
TI  - Public Health Administration in Australia.

PMID- 29829521
TI  - Round the Hospitals.

PMID- 29829520
TI  - Safe Milk.

PMID- 29829522
TI  - Motherhood a Lost Art?

PMID- 29829523
TI  - Children in the Cotton Trade.

PMID- 29829525
TI  - Post-Graduate Assistance.

PMID- 29829524
TI  - Scrapping the Trained Nurse.

PMID- 29829526
TI  - New Health Provisions.

PMID- 29829527
TI  - The Wards as a Patient Sees Them.

PMID- 29829528
TI  - Hospital and Institutional News.

PMID- 29829529
TI  - Sanitary Blocks of Hospitals.

PMID- 29829530
TI  - Gun-Shot Wounds of the Jaw and Facial Injuries: I. Some Nursing Aspects.

PMID- 29829531
TI  - Annual Meetings of Hospitals.

PMID- 29829532
TI  - A Larger Income and Smaller Debt.

PMID- 29829533
TI  - More Expert Opinion.

PMID- 29829535
TI  - The Editor's Letter-Box.

PMID- 29829534
TI  - Contributions from Patients.

PMID- 29829537
TI  - Child-Welfare Progress.

PMID- 29829536
TI  - Acute Encephalitis Lethargica.

PMID- 29829538
TI  - Contributions from Patients.

PMID- 29829540
TI  - The History of the British Officers' Library, Stralsund, Germany.

PMID- 29829539
TI  - School Medical and Nursing Service in the Transvaal.

PMID- 29829541
TI  - World Health.

PMID- 29829542
TI  - The Value of a Nursing Certificate.

PMID- 29829543
TI  - The Bias Towards Disease.

PMID- 29829544
TI  - Hospital and Institutional News.

PMID- 29829545
TI  - Parliament and the Professions.

PMID- 29829546
TI  - The Capital of the Central Funds.

PMID- 29829548
TI  - In Medical and Surgical Practice.

PMID- 29829547
TI  - Altar of Domestic Dirt.

PMID- 29829550
TI  - The Medical Streets.

PMID- 29829549
TI  - Venereal Diseases among Seamen.

PMID- 29829551
TI  - The Passing of Prejudice.

PMID- 29829552
TI  - The Reform of Prison Life.

PMID- 29829553
TI  - British Pharmaceutical Conference.

PMID- 29829554
TI  - Pestilential Streams.

PMID- 29829556
TI  - The National Physique.

PMID- 29829555
TI  - The Status of Hospital Domestic Service.

PMID- 29829557
TI  - Decision Not to Realise Capital.

PMID- 29829558
TI  - Difficulties at Lambeth Infirmary.

PMID- 29829560
TI  - An Excellent Lecture and Demonstration.

PMID- 29829559
TI  - Venereal Prevention.

PMID- 29829562
TI  - Round the Hospitals.

PMID- 29829561
TI  - Derby Sanatorium Inquiry.

PMID- 29829563
TI  - Round the Hospitals.

PMID- 29829565
TI  - Demobilised Men.

PMID- 29829564
TI  - Patient's Payments.

PMID- 29829566
TI  - The Choice before Us.

PMID- 29829567
TI  - Baby Clinic Experiences.

PMID- 29829569
TI  - Two Schemes in Hereford and Suffolk.

PMID- 29829568
TI  - Women and Night Work.

PMID- 29829570
TI  - Hospital and Institutional News.

PMID- 29829571
TI  - A Tribute to English Medical Science.

PMID- 29829572
TI  - Science and the Nation.

PMID- 29829573
TI  - Parliament and the Professions.

PMID- 29829575
TI  - The Views of a Hospital Secretary.

PMID- 29829574
TI  - Hospital Finance.

PMID- 29829576
TI  - Memorandum of Arrangements Proposed by the Minister of Pensions.

PMID- 29829577
TI  - The French Memorial of Edith Cavell.

PMID- 29829578
TI  - The Specialist.

PMID- 29829579
TI  - Institutional Needs.

PMID- 29829580
TI  - Vertigo.

PMID- 29829581
TI  - A Step on the Road to Success.

PMID- 29829583
TI  - Medical War Service.

PMID- 29829582
TI  - What the Vitamine Theories Mean in Practice.

PMID- 29829584
TI  - The Conference Habit.

PMID- 29829585
TI  - A Question of Eugenics.

PMID- 29829587
TI  - Round the Hospitals.

PMID- 29829586
TI  - News from South Africa.

PMID- 29829589
TI  - A Capitation Grant Fallacy.

PMID- 29829588
TI  - Some Advice of a Practical Nature.

PMID- 29829590
TI  - Children's Hospital for Johannesburg.

PMID- 29829591
TI  - The Journal of Neurology and Psychopathology.

PMID- 29829593
TI  - Ideals in the Operating-Theatre.

PMID- 29829592
TI  - The New Outlook.

PMID- 29829595
TI  - To-Day and Yesterday.

PMID- 29829594
TI  - Payments by Patients.

PMID- 29829596
TI  - The Appeal for Ex-Service Men.

PMID- 29829597
TI  - The Summer School of Civics.

PMID- 29829598
TI  - American View of His Work.

PMID- 29829599
TI  - State Registration and Its Values.

PMID- 29829600
TI  - Dr. Hamer's Report for the Year 1919.

PMID- 29829601
TI  - Status of Hospital Domestic Service.

PMID- 29829603
TI  - The Welsh School of Social Service.

PMID- 29829602
TI  - Hospital and Institutional News.

PMID- 29829605
TI  - Cholera in Korea.

PMID- 29829604
TI  - Saving the Children.

PMID- 29829606
TI  - An Analysis of Ophthalmic Cases.

PMID- 29829607
TI  - Making the Public Understand.

PMID- 29829608
TI  - The Hospitals Problem.

PMID- 29829609
TI  - Medical Officers Object to Whole-Time Service.

PMID- 29829610
TI  - Chemists' Scholarships Go Begging.

PMID- 29829611
TI  - A Hospital Fete Story.

PMID- 29829612
TI  - The New Feminism.

PMID- 29829613
TI  - Domestic Animals and Human Infection.

PMID- 29829615
TI  - An Epidemic Experiment.

PMID- 29829614
TI  - Three Weeks in an Eye Hospital.

PMID- 29829616
TI  - A Strange Conditional Legacy.

PMID- 29829617
TI  - The St. Andrew's Association's Work.

PMID- 29829618
TI  - Eurhythmics and Health.

PMID- 29829619
TI  - Shorter Hours for Welsh Mothers.

PMID- 29829620
TI  - Working-Boys' Club.

PMID- 29829621
TI  - A Brighter Outlook on the Hospital's Position.

PMID- 29829622
TI  - New Rates for Army Nurses.

PMID- 29829623
TI  - A Kindly Glasgow Citizen.

PMID- 29829624
TI  - The Teaching of Physiology.

PMID- 29829625
TI  - Recent Observations in Immunity Production.

PMID- 29829627
TI  - A Surgical Tuberculosis Scheme.

PMID- 29829626
TI  - Making the Public Understand.

PMID- 29829628
TI  - The Limitations of a Voluntary Register.

PMID- 29829629
TI  - Hospital and Institutional News.

PMID- 29829630
TI  - The Scandal of Empty Houses.

PMID- 29829631
TI  - Needs Must When.

PMID- 29829632
TI  - Progress of the London's Experiment.

PMID- 29829633
TI  - Heard in the Corridor.

PMID- 29829634
TI  - Round the Hospitals.

PMID- 29829635
TI  - What Smoke Costs.

PMID- 29829636
TI  - Business Houses and the Hospitals.

PMID- 29829637
TI  - Perils of the Restaurant.

PMID- 29829638
TI  - Condensed Milk as Infants' Food.

PMID- 29829639
TI  - The Extended Term of Training.

PMID- 29829640
TI  - Hospital and Institutional News.

PMID- 29829641
TI  - Eighteenth Century Methods.

PMID- 29829642
TI  - Doctor's Heroism.

PMID- 29829643
TI  - A Question of Contact Isolation.

PMID- 29829645
TI  - Honorary Medical Staffs of Hospitals.

PMID- 29829644
TI  - The Gradual Changes and Their Unknown Cause.

PMID- 29829646
TI  - Round the Hospitals.

PMID- 29829647
TI  - Proposed New Rule for C.M.B. Candidates.

PMID- 29829649
TI  - Lord Dawson's Scheme.

PMID- 29829648
TI  - Important National Congress.

PMID- 29829650
TI  - A Recent and Valuable Method.

PMID- 29829651
TI  - Hospital Annual Meetings.

PMID- 29829652
TI  - The Lay Contributor.

PMID- 29829653
TI  - The National Scheme.

PMID- 29829654
TI  - The Hospital Saturday Fund.

PMID- 29829655
TI  - The London Hospital's Appeal.

PMID- 29829656
TI  - The Status of the Trained Nurse.

PMID- 29829657
TI  - Mr. G. Q. Roberts's Interesting Lecture.

PMID- 29829658
TI  - A Sneer at Doctors.

PMID- 29829659
TI  - A Great Hospital's Work under Trying Conditions.

PMID- 29829660
TI  - The Dangerous Telephone-Box.

PMID- 29829662
TI  - Nurses as Health Visitors.

PMID- 29829661
TI  - The Idea of Progress.

PMID- 29829663
TI  - The West Midland Region Meeting at Birmingham.

PMID- 29829664
TI  - Life in a Chinese Hospital.

PMID- 29829665
TI  - Coming Developments in Port Sanitary Administration.

PMID- 29829666
TI  - Dame Swift on Nursing Abuses.

PMID- 29829668
TI  - The Hospital Problem.

PMID- 29829667
TI  - Cinema to Help a Hospital.

PMID- 29829669
TI  - Children in Workhouses.

PMID- 29829670
TI  - The Danger of Typhus.

PMID- 29829672
TI  - Anaemia as a True Disease.

PMID- 29829671
TI  - State Registration and Its Values.

PMID- 29829674
TI  - Payments at Norwich.

PMID- 29829673
TI  - To Combat Industrial Fatigue.

PMID- 29829675
TI  - The Gift of Expression.

PMID- 29829676
TI  - The Gastric Function.

PMID- 29829677
TI  - An Ideal Elementary School.

PMID- 29829678
TI  - Mental Patients in War Hospitals.

PMID- 29829680
TI  - Round the Hospitals.

PMID- 29829679
TI  - Domestic Arts and Housing.

PMID- 29829682
TI  - Vivisection.

PMID- 29829681
TI  - The Ex-Soldier.

PMID- 29829684
TI  - An Autumn Campaign.

PMID- 29829683
TI  - Hospital and Institutional News.

PMID- 29829686
TI  - Training the Blind.

PMID- 29829685
TI  - Should Voluntary and Poor-Law Hospitals Combine?

PMID- 29829687
TI  - Venereal Prevention.

PMID- 29829688
TI  - The Wages and Employment Conditions of Unskilled Workers.

PMID- 29829689
TI  - The Opening of the Princess Alice Home, Middlesex Hospital.

PMID- 29829690
TI  - Sir Napier Burnett and Employers' Subscriptions.

PMID- 29829691
TI  - Unrest in Infirmary Wards.

PMID- 29829692
TI  - Parliament and the Professions.

PMID- 29829693
TI  - Startling Suggestion.

PMID- 29829694
TI  - Big Public Welfare Programme.

PMID- 29829696
TI  - An Unsolved Mystery.

PMID- 29829695
TI  - A Hospital Treasurer's Suggestion.

PMID- 29829697
TI  - The Art of Healing.

PMID- 29829698
TI  - The Uses of Freedom in Nursing Administration.

PMID- 29829699
TI  - Hospital and Institutional News.

PMID- 29829700
TI  - A Treasurer's Valuable Suggestions.

PMID- 29829701
TI  - The Domestic Grate.

PMID- 29829702
TI  - Some Comments and a Criticism.

PMID- 29829703
TI  - Protection of Vaccination Wounds.

PMID- 29829704
TI  - The Hospital Magazines and Journals.

PMID- 29829705
TI  - Employers' Subscriptions at Sheffield.

PMID- 29829706
TI  - The Lessons of the Hospital Survey.

PMID- 29829707
TI  - National Health and Modern Problems.

PMID- 29829708
TI  - Round the Hospitals.

PMID- 29829709
TI  - Adopted Children and State Control.

PMID- 29829710
TI  - Report of the Committee of Selection.

PMID- 29829711
TI  - Social Welfare.

PMID- 29829712
TI  - The Dangerous Telephone Box.

PMID- 29829713
TI  - The Status of Hospital Domestic Service.

PMID- 29829714
TI  - Earl Haig at Cardiff.

PMID- 29829715
TI  - Poor-Law Nurses and Trade Unions.

PMID- 29829717
TI  - A National Responsibility.

PMID- 29829716
TI  - Children and Strong Drink.

PMID- 29829718
TI  - Recreation at School Age.

PMID- 29829719
TI  - Salaries at the General Hospital, Wellington.

PMID- 29829720
TI  - Group Infection by the Bacillus Suipestifer.

PMID- 29829721
TI  - Invalid and Crippled Children.

PMID- 29829723
TI  - Parliament and the Professions.

PMID- 29829722
TI  - Vital Statistics.

PMID- 29829724
TI  - The Nurse-Apprentice.

PMID- 29829725
TI  - Round the Hospitals.

PMID- 29829727
TI  - The Way of Attainment.

PMID- 29829726
TI  - Crawling Exercises for Scoliosis.

PMID- 29829729
TI  - A New Milk Combine.

PMID- 29829728
TI  - Results Obtained with Protective Serum.

PMID- 29829730
TI  - Hospital and Institutional News.

PMID- 29829731
TI  - Welfare and Labour.

PMID- 29829732
TI  - Employers and the Ex-Service Man.

PMID- 29829733
TI  - Co-Operative Colonies for Incurable Neurasthenics.

PMID- 29829734
TI  - Parliament and the Professions.

PMID- 29829735
TI  - How Voluntary Workers and the State Can Help.

PMID- 29829736
TI  - The Grants Recommended.

PMID- 29829737
TI  - A Quarter of a Million for Extensions and Improvements.

PMID- 29829739
TI  - The Woman Worker's World.

PMID- 29829738
TI  - New Zealand Hospital Board's Conference.

PMID- 29829741
TI  - Hospital and Institutional News.

PMID- 29829740
TI  - Women Doctors.

PMID- 29829742
TI  - The Vision of Cleanliness.

PMID- 29829743
TI  - The Editor's Letter-Box.

PMID- 29829744
TI  - The Legal Aspects.

PMID- 29829745
TI  - National Health and Modern Problems.

PMID- 29829746
TI  - An Entrance Examination for Probationers.

PMID- 29829747
TI  - The Guy's Appeal.

PMID- 29829748
TI  - The Aftermath of War.

PMID- 29829749
TI  - Opening of Two New Buildings.

PMID- 29829750
TI  - Schemes for Co-Operation.

PMID- 29829752
TI  - Plain Speaking on Tuberculosis Matters.

PMID- 29829751
TI  - Income-Raising Device in the Antipodes.

PMID- 29829753
TI  - Malarial Fever in England.

PMID- 29829754
TI  - The De La Rue Scheme of Medical Service.

PMID- 29829756
TI  - Birth Control.

PMID- 29829755
TI  - Male Nursing.

PMID- 29829757
TI  - Venereal Prevention.

PMID- 29829758
TI  - Round the Hospitals.

PMID- 29829759
TI  - The Conquest of Venereal Disease.

PMID- 29829760
TI  - Hospital Problems in India.

PMID- 29829761
TI  - Vitamines and Domestic Education.

PMID- 29829763
TI  - Venereal Prevention.

PMID- 29829762
TI  - Research Records as They Stand To-Day.

PMID- 29829764
TI  - The Preparation of the Patient.

PMID- 29829765
TI  - The Nurses' Resolution.

PMID- 29829766
TI  - The Ugly Word.

PMID- 29829767
TI  - The Editor's Letter-Box.

PMID- 29829769
TI  - The Hospital Survey and Its Lessons.

PMID- 29829768
TI  - The Finances of the Voluntary Hospitals.

PMID- 29829770
TI  - Maternity and Welfare Work.

PMID- 29829771
TI  - Public Sanitation.

PMID- 29829772
TI  - Hardships of the Middle Class.

PMID- 29829773
TI  - Hospital and Institutional News.

PMID- 29829775
TI  - Modern Urology.

PMID- 29829774
TI  - The Cambridge Discussion Summarised.

PMID- 29829776
TI  - The Story of Hospital Sunday.

PMID- 29829777
TI  - The Universities in Research and in Practice.

PMID- 29829778
TI  - A Successful View Day.

PMID- 29829779
TI  - Round the Hospitals.

PMID- 29829780
TI  - Its Objects Attained.

PMID- 29829781
TI  - Why There Is No Poor Law.

PMID- 29829782
TI  - The Dangerous Telephone-Box.

PMID- 29829784
TI  - Professional Secrecy and Professional Confidences.

PMID- 29829783
TI  - Union in the Nursing Profession.

PMID- 29829786
TI  - The Medical Curriculum.

PMID- 29829785
TI  - Parliament and the Professions.

PMID- 29829787
TI  - Health Insurance.

PMID- 29829788
TI  - King's Fund Emergency Distribution.

PMID- 29829789
TI  - Tax-Free Benefactions.

PMID- 29829790
TI  - Liverpool Child Welfare.

PMID- 29829792
TI  - Six Short Welfare Conferences.

PMID- 29829791
TI  - The Doctor and His Patient.

PMID- 29829794
TI  - Health Versus Disease.

PMID- 29829793
TI  - World Housing Conference.

PMID- 29829795
TI  - The "Will to Health."

PMID- 29829796
TI  - The Place of Industrial Medicine.

PMID- 29829797
TI  - Some Essential Considerations.

PMID- 29829798
TI  - Hygiene and the Elementary School Teacher.

PMID- 29829799
TI  - Parliament and the Professions.

PMID- 29829800
TI  - Hostels for Unmarried Mothers.

PMID- 29829801
TI  - The National Relief Fund.

PMID- 29829802
TI  - Nurses' Hours.

PMID- 29829804
TI  - The Obstetric Training of the Medical Student.

PMID- 29829803
TI  - The Supply of Doctors.

PMID- 29829806
TI  - Sportsmen and Charity.

PMID- 29829805
TI  - Round the Hospitals.

PMID- 29829808
TI  - The Views of a Provincial Hospital Secretary.

PMID- 29829807
TI  - News from South Africa.

PMID- 29829809
TI  - Severe Criticism.

PMID- 29829811
TI  - Impressions from Brussels.

PMID- 29829810
TI  - Experiments on Animals.

PMID- 29829812
TI  - Specially Communicated by an M.O.H.

PMID- 29829813
TI  - From across the Seas.

PMID- 29829814
TI  - Not Substitutes for Mothers.

PMID- 29829815
TI  - Nurses and an Eight-Hour Day.

PMID- 29829816
TI  - Hospital and Institutional News.

PMID- 29829817
TI  - Self-Determination for Nurses.

PMID- 29829819
TI  - General Nursing Council for Scotland.

PMID- 29829818
TI  - A Promising Aid to Therapy.

PMID- 29829821
TI  - The Backbone of the College Finances.

PMID- 29829820
TI  - Round the Hospitals.

PMID- 29829822
TI  - Welfare in Factories.

PMID- 29829823
TI  - Hospital and Institutional News.

PMID- 29829824
TI  - Behind the Scenes on Hospital Sunday.

PMID- 29829825
TI  - Child Welfare in Manchester.

PMID- 29829826
TI  - A Sanatorium Protest.

PMID- 29829827
TI  - The Spirit of Sacrifice and Service.

PMID- 29829828
TI  - Great Men and Movements of the past.

PMID- 29829829
TI  - Parliament and the Professions.

PMID- 29829830
TI  - Should They Be Relinquished for the Countryside?

PMID- 29829831
TI  - Hospitals and Their Special Needs.

PMID- 29829832
TI  - A Wider Field.

PMID- 29829833
TI  - The Chivalrous Lord Chancellor.

PMID- 29829834
TI  - London Needs L350,000 Now.

PMID- 29829835
TI  - Annual Meeting of Governors.

PMID- 29829837
TI  - An Emergency Distribution of L250,000.

PMID- 29829836
TI  - Royal British Nurses' Association.

PMID- 29829838
TI  - A Suggestion to the Three Funds.

PMID- 29829839
TI  - Fifth Annual Meeting.

PMID- 29829841
TI  - 1919. A Year's Work in the Hospitals and Medical Charities of London.

PMID- 29829840
TI  - Do the People Understand?

PMID- 29829842
TI  - The Threat from the East and the Tropics.

PMID- 29829843
TI  - Special Hospitals and Graduate Study.

PMID- 29829844
TI  - The Opportunities and Outlook.

PMID- 29829845
TI  - Its Attractions and Prospects.

PMID- 29829846
TI  - State Registration and Its Values.

PMID- 29829847
TI  - Cambridge University Course.

PMID- 29829848
TI  - The Royal Naval Medical Service.

PMID- 29829849
TI  - Graduate Education and Institutions.

PMID- 29829850
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29829851
TI  - Bishops and the Birth-Rate.

PMID- 29829852
TI  - The Future of Medicine and the Medical Profession.

PMID- 29829853
TI  - The Work of the Fellowship of Medicine.

PMID- 29829855
TI  - Medical Schools in Scotland.

PMID- 29829854
TI  - Increases in Nurses' Retired Pay.

PMID- 29829857
TI  - Psychology in Tuberculosis.

PMID- 29829856
TI  - Navy, Army, Air and Colonial Services.

PMID- 29829858
TI  - The Royal Army Medical Corps.

PMID- 29829859
TI  - The Infirmary Branch and Its Attractions for the Newly Qualified.

PMID- 29829861
TI  - The English Conjoint Course.

PMID- 29829860
TI  - Needs Must When.

PMID- 29829862
TI  - Needs Must When.

PMID- 29829864
TI  - London.

PMID- 29829863
TI  - Making the Public Understand.

PMID- 29829866
TI  - Oxford University Course.

PMID- 29829865
TI  - Research and the Medical Student.

PMID- 29829867
TI  - Medical Schools in the Provinces.

PMID- 29829868
TI  - Medical Schools in Ireland.

PMID- 29829870
TI  - Qualification and Registration.

PMID- 29829869
TI  - Some Advice to Those Now Entering.

PMID- 29829871
TI  - What It Offers to the Newly-Qualified and Others.

PMID- 29829872
TI  - Higher Diplomas.

PMID- 29829873
TI  - School Medical and Nursing Services in South Africa.

PMID- 29829874
TI  - Hospital and Institutional News.

PMID- 29829875
TI  - London University Course.

PMID- 29829876
TI  - Work of the Port of London Sanitary Committee.

PMID- 29829878
TI  - The Uses of a Syllabus.

PMID- 29829877
TI  - The New Local Hospital Committees.

PMID- 29829879
TI  - A Complete Programme of Child Welfare.

PMID- 29829880
TI  - Round the Hospitals.

PMID- 29829882
TI  - Notes of the Week.

PMID- 29829881
TI  - Distribution of L100,170.

PMID- 29829884
TI  - The Relation of the Medical Profession.

PMID- 29829883
TI  - Buying Difficulties of the Present Day.

PMID- 29829886
TI  - Doctors' Fees and Patients' Payments.

PMID- 29829885
TI  - Parliament and the Professions.

PMID- 29829887
TI  - The Westminster Conference.

PMID- 29829888
TI  - General Nursing Council for Scotland.

PMID- 29829890
TI  - The Pay of the Nurse. V.-A Comparison with Other Occupations.

PMID- 29829889
TI  - Literature and License.

PMID- 29829891
TI  - The Refuse Disposal of London.

PMID- 29829892
TI  - Resident Operating Surgeons?

PMID- 29829894
TI  - The Doctor and the Strike.

PMID- 29829893
TI  - The Truth about Venereal Disease.

PMID- 29829895
TI  - A Public Warning.

PMID- 29829896
TI  - A New Light on Florence Nightingale.

PMID- 29829897
TI  - Dr. Addison Goes.

PMID- 29829898
TI  - Notes of the Week.

PMID- 29829899
TI  - Some Valuable Notes for Practitioners.

PMID- 29829900
TI  - Annual Meetings of Hospitals.

PMID- 29829902
TI  - The Repair of Graves and Head-Stones.

PMID- 29829901
TI  - Nurses Want a Career.

PMID- 29829903
TI  - Caring for the Adolescent.

PMID- 29829904
TI  - Dublin Castle and the Royal College of Surgeons.

PMID- 29829905
TI  - Should Nurses Smoke?

PMID- 29829906
TI  - The Cause of Medicine.

PMID- 29829907
TI  - A Reflection.

PMID- 29829908
TI  - Round the Hospitals.

PMID- 29829909
TI  - The Registered Children's Nurse.

PMID- 29829910
TI  - Round the Hospitals.

PMID- 29829911
TI  - The New Methods of Treatment.

PMID- 29829912
TI  - An Appreciation.

PMID- 29829913
TI  - Educational Films.

PMID- 29829914
TI  - Two Methods of Nursing Insured Persons.

PMID- 29829915
TI  - Harley Street.

PMID- 29829916
TI  - The Moral of Recent Experience.

PMID- 29829918
TI  - Notes of the Week.

PMID- 29829917
TI  - Mr. Keyser's Proposal.

PMID- 29829919
TI  - Fighting a Universal Plague.

PMID- 29829921
TI  - The Federation of Medical and Allied Societies.

PMID- 29829920
TI  - The Hospital Pageant Meeting.

PMID- 29829923
TI  - The Search for the Soul.

PMID- 29829922
TI  - Closing of Wards at the London Hospital.

PMID- 29829924
TI  - The Departmental Committee's Report.

PMID- 29829925
TI  - The Best Methods for Newly Claimed Areas.

PMID- 29829926
TI  - The Royal British Nurses' Association Club.

PMID- 29829927
TI  - The Economy of Child-Saving.

PMID- 29829929
TI  - The Hospital Pageant.

PMID- 29829928
TI  - "Saving" Half-A-Million.

PMID- 29829930
TI  - General Agreement.

PMID- 29829931
TI  - The Year's Work of the College of Nursing.

PMID- 29829932
TI  - Lectures for Mothers.

PMID- 29829933
TI  - The Typhus Situation.

PMID- 29829934
TI  - Conferences at the Nursing and Midwifery Exhibition.

PMID- 29829935
TI  - Parliament and the Professions.

PMID- 29829936
TI  - Round the Hospitals.

PMID- 29829937
TI  - The Profession and the Ministry.

PMID- 29829939
TI  - Annual Meetings of Hospitals.

PMID- 29829938
TI  - From the Patient's Point of View.

PMID- 29829940
TI  - X-Ray and Radium Protection Committee.

PMID- 29829941
TI  - Industrially Employed Mothers.

PMID- 29829942
TI  - Customs, Fashions and Colds.

PMID- 29829943
TI  - Notes of the Week.

PMID- 29829944
TI  - Happy Old Age.

PMID- 29829945
TI  - The New Secretary of Westminster Hospital.

PMID- 29829947
TI  - A Hospital Pageant?

PMID- 29829946
TI  - Customs to Be Condemned.

PMID- 29829949
TI  - Parliament and the Professions.

PMID- 29829948
TI  - Freedom of the General Nursing Council Imperilled.

PMID- 29829951
TI  - The New Spirit of Reciprocity.

PMID- 29829950
TI  - Brightening Medical Reports.

PMID- 29829953
TI  - Why Animal Experiment Is Necessary.

PMID- 29829952
TI  - Is a Workable Scheme Still to Be Found?

PMID- 29829954
TI  - Notes of the Week.

PMID- 29829955
TI  - A "Red Cross" Warning.

PMID- 29829956
TI  - Annual Meetings of Hospitals.

PMID- 29829957
TI  - Industrial Health.

PMID- 29829958
TI  - Round the Hospitals.

PMID- 29829959
TI  - The College Council Elections.

PMID- 29829960
TI  - An Address to the Kensington Branch of the League of Nations Union.

PMID- 29829961
TI  - On Looking the Age of Consent.

PMID- 29829962
TI  - The Pay of the Nurse. VI.-The Lack of Superannuation.

PMID- 29829963
TI  - Notes of the Week.

PMID- 29829964
TI  - Some Orthopaedic Principles Explained.

PMID- 29829965
TI  - Round the Hospitals.

PMID- 29829966
TI  - A First Publication by the International Labour Office.

PMID- 29829967
TI  - Annual Meetings of Hospitals.

PMID- 29829968
TI  - A C 3 "Bogey".

PMID- 29829969
TI  - Health in the Schools.

PMID- 29829970
TI  - Lectures to Patients.

PMID- 29829972
TI  - The City Road.

PMID- 29829971
TI  - Should Nurses Strike?

PMID- 29829973
TI  - The Edinburgh Tuberculosis Decision.

PMID- 29829974
TI  - Village and Country Town Concerts.

PMID- 29829976
TI  - Parliament and the Professions.

PMID- 29829975
TI  - The Events of a Critical Period.

PMID- 29829978
TI  - The Rat Pest.

PMID- 29829977
TI  - A General Effort.

PMID- 29829979
TI  - Draft Rules Now Available.

PMID- 29829980
TI  - The Notification of Measles.

PMID- 29829982
TI  - The Economic Waste of Illness.

PMID- 29829981
TI  - Round the Hospitals.

PMID- 29829983
TI  - An Active Building Programme at Leicester.

PMID- 29829984
TI  - The Government and the Hospitals.

PMID- 29829986
TI  - The Federation of Medical and Allied Societies.

PMID- 29829985
TI  - What Recent Announcements Really Mean.

PMID- 29829987
TI  - Crime and Unemployment.

PMID- 29829988
TI  - The Folkestone Health Congress.

PMID- 29829989
TI  - The Conference at Manchester.

PMID- 29829990
TI  - The Anthrax Order.

PMID- 29829992
TI  - The Manchester Conference of 1911.

PMID- 29829991
TI  - Notes of the Week.

PMID- 29829993
TI  - Fever Nurses and the General Register.

PMID- 29829994
TI  - Mr. Keyser's Proposal.

PMID- 29829995
TI  - Notes of the Week.

PMID- 29829996
TI  - The Spirit of Charity and Its Origin.

PMID- 29829997
TI  - A Blind Policy.

PMID- 29829998
TI  - The Voluntary Hospitals Committee.

PMID- 29829999
TI  - The Cirencester Experiment.

PMID- 29830000
TI  - The Forthcoming State Register.

PMID- 29830002
TI  - Some Essentials in Diagnosing Abdominal Cases.

PMID- 29830001
TI  - Refinements in Radiography.

PMID- 29830003
TI  - Call in the Doctor.

PMID- 29830004
TI  - Meeting of the General Nursing Council for England and Wales.

PMID- 29830005
TI  - The Widening Fields of Public Health.

PMID- 29830007
TI  - A New International Nursing Course.

PMID- 29830006
TI  - Recreation and Juvenile Crime.

PMID- 29830008
TI  - The Cave Report.

PMID- 29830009
TI  - Round the Hospitals.

PMID- 29830010
TI  - The Death-Rate of Mothers.

PMID- 29830011
TI  - The Dangerous Drugs Hospital Scheme.

PMID- 29830013
TI  - Bacteriological Pitfalls.

PMID- 29830012
TI  - Official Advice.

PMID- 29830014
TI  - Round the Hospitals.

PMID- 29830015
TI  - Parliament and the Professions.

PMID- 29830016
TI  - Annual Meeting.

PMID- 29830017
TI  - Doctor and Patient.

PMID- 29830019
TI  - Some Light on a Recent Controversy.

PMID- 29830018
TI  - The King's Fund and a Hospital Policy.

PMID- 29830020
TI  - Maternity and Child-Welfare Centres.

PMID- 29830021
TI  - The Future of the Infirmary.

PMID- 29830022
TI  - The Plea of Impulse.

PMID- 29830023
TI  - Notes of the Week.

PMID- 29830024
TI  - Red Cross Conference on Venereal Diseases.

PMID- 29830025
TI  - The Onus of Helping Necessitous Nurses.

PMID- 29830026
TI  - Sympathetic Encouragement to Group Clinics.

PMID- 29830027
TI  - The Practice of Birth-Control.

PMID- 29830028
TI  - Instructing the Public.

PMID- 29830029
TI  - Superannuation and the Young Nurse.

PMID- 29830030
TI  - Conditions of Admission to the Register.

PMID- 29830031
TI  - Interim Report by King's Fund Policy Committee.

PMID- 29830032
TI  - King Edward's Fund Policy.

PMID- 29830033
TI  - Annual Meetings of Hospitals.

PMID- 29830035
TI  - Medical Officers and Food Problems.

PMID- 29830034
TI  - Parliament and the Professions.

PMID- 29830037
TI  - Notes of the Week.

PMID- 29830036
TI  - Facts for and against.

PMID- 29830038
TI  - Round the Hospitals.

PMID- 29830039
TI  - Waist-Bands for Fat Men.

PMID- 29830040
TI  - The Absence of Educational Grades.

PMID- 29830041
TI  - The Short Cut to Sanity.

PMID- 29830043
TI  - The Organised Practice of Massage.

PMID- 29830042
TI  - Possible Economies with Steam Boilers.

PMID- 29830044
TI  - The Pay of the Nurse. VII.-Causes of Low Salaries.

PMID- 29830045
TI  - Some Notes on an Everyday Problem.

PMID- 29830047
TI  - The Almoners' Council and Patients' Payments.

PMID- 29830046
TI  - Consult the Doctor.

PMID- 29830049
TI  - Athletics for Girls.

PMID- 29830048
TI  - Security for the Masseur and the Masseuse.

PMID- 29830050
TI  - A Plea for More Drastic Control.

PMID- 29830051
TI  - School Clinics.

PMID- 29830052
TI  - The Employer's Liability.

PMID- 29830053
TI  - The Crisis Once More.

PMID- 29830054
TI  - Hospital Claims and the Insurance Surplus.

PMID- 29830055
TI  - Possible Economies with Steam Boilers.

PMID- 29830056
TI  - Notes of the Week.

PMID- 29830057
TI  - Government Food Pamphlets.

PMID- 29830058
TI  - Human Ideals in Industry.

PMID- 29830059
TI  - Counter-Irritation as a Means to Co-Ordination.

PMID- 29830060
TI  - "Carriers" of Disease.

PMID- 29830061
TI  - The Next Step at the "London".

PMID- 29830062
TI  - First-Year Training-Schools.

PMID- 29830063
TI  - The Fly Pest.

PMID- 29830064
TI  - The Modern Treatment of Ringworm.

PMID- 29830065
TI  - Parliament and the Professions.

PMID- 29830066
TI  - Is a Hospital Pageant Practicable?

PMID- 29830067
TI  - Round the Hospitals.

PMID- 29830068
TI  - Annual Meetings of Hospitals.

PMID- 29830069
TI  - Is a Hospital Pageant Practicable?

PMID- 29830070
TI  - Is a Hospital Pageant Practicable?

PMID- 29830071
TI  - Is a Hospital Pageant Practicable?

PMID- 29830072
TI  - King Edward's Memorial Homes for Nurses.

PMID- 29830073
TI  - The Practice of Birth-Control.

PMID- 29830074
TI  - The Elixir of Youth.

PMID- 29830075
TI  - Parliament and the Professions.

PMID- 29830076
TI  - The General Nursing Council of England and Wales.

PMID- 29830077
TI  - Doctor and Patient.

PMID- 29830078
TI  - Sir George Newman's Annual Report.

PMID- 29830079
TI  - The King's Fund and the Government Grant.

PMID- 29830081
TI  - Notes of the Week.

PMID- 29830080
TI  - Unveiling by the Duke of York.

PMID- 29830082
TI  - The Use and Abuse of Medical Literature.

PMID- 29830083
TI  - Powers Obtained by Grimsby Corporation.

PMID- 29830084
TI  - Acquisitions and Research.

PMID- 29830085
TI  - Competition Thesis in Radiography and Electro-Therapy.

PMID- 29830086
TI  - A Still Greater Effort Required.

PMID- 29830087
TI  - The Non-Residential Preliminary School.

PMID- 29830088
TI  - Official Policy Defined.

PMID- 29830089
TI  - Round the Hospitals.

PMID- 29830090
TI  - A Note on Scottish Hospital History.

PMID- 29830091
TI  - As Organised by and Worked at the Radcliffe Infirmary.

PMID- 29830092
TI  - Parliament and the Professions.

PMID- 29830093
TI  - A Lesson from America.

PMID- 29830094
TI  - Some Reflections by an Ex-Patient.

PMID- 29830095
TI  - "The Surgeon's Daughter," by Sir Walter Scott.

PMID- 29830096
TI  - Some Results of Nurses' Insurance.

PMID- 29830097
TI  - The Prince at Bristol and Cardiff.

PMID- 29830099
TI  - The Financial Crisis.

PMID- 29830098
TI  - Co-Operation Schemes.

PMID- 29830100
TI  - An Age of Specialism.

PMID- 29830101
TI  - Notes of the Week.

PMID- 29830102
TI  - Dangerous Drugs Act.

PMID- 29830103
TI  - The Voluntary Hospitals Committee.

PMID- 29830104
TI  - Notes on the Cave Committee's Report.

PMID- 29830105
TI  - Opening of the Official Home.

PMID- 29830106
TI  - Closed Ward Reopened at Norwich.

PMID- 29830108
TI  - A Temple of Harmony.

PMID- 29830107
TI  - Cholera at Salonica.

PMID- 29830110
TI  - Electrical Thermometers and Boiler Temperatures.

PMID- 29830111
TI  - The Registration of Scottish Fever Nurses.

PMID- 29830109
TI  - Discharging Patients for Lack of Nurses.

PMID- 29830112
TI  - Round the Hospitals.

PMID- 29830113
TI  - Sanitary Reform.

PMID- 29830114
TI  - Round the Hospitals.

PMID- 29830115
TI  - Waist-Bands for Fat Men.

PMID- 29830117
TI  - The Fight against Disease.

PMID- 29830116
TI  - Research on the Common Fevers.

PMID- 29830118
TI  - Annual Meetings of Hospitals.

PMID- 29830119
TI  - What Is a Colloid?

PMID- 29830120
TI  - Parliament and the Professions.

PMID- 29830121
TI  - War Memorial Hospital in Zululand.

PMID- 29830123
TI  - The Practice of Birth-Control.

PMID- 29830122
TI  - An Address to the Kensington Branch of the League of Nations Union.

PMID- 29830124
TI  - Children and Crime.

PMID- 29830125
TI  - The Healthy Mind.

PMID- 29830127
TI  - The Editor's Letter-Box.

PMID- 29830126
TI  - The Appeal of the Invalid Child.

PMID- 29830128
TI  - The Pay of the Nurse. VIII.-The Outlook for the Future.

PMID- 29830129
TI  - A Training for Hospital Executives.

PMID- 29830131
TI  - Popular Health Methods.

PMID- 29830130
TI  - Notes of the Week.

PMID- 29830132
TI  - The Illegitimate Child.

PMID- 29830133
TI  - A Paying Hospital for All Classes and All Incomes.

PMID- 29830135
TI  - The Hospital Profession.

PMID- 29830134
TI  - An Industrial Clinic.

PMID- 29830137
TI  - The Effects of Invisible Solar Rays.

PMID- 29830136
TI  - The British Hospitals Association.

PMID- 29830139
TI  - The "Newman Policy".

PMID- 29830138
TI  - The Fly Pest.

PMID- 29830140
TI  - The Editor's Letter-Box.

PMID- 29830142
TI  - Annual Meetings of Hospitals.

PMID- 29830141
TI  - The Guardianship of Children.

PMID- 29830144
TI  - Parliament and the Profession.

PMID- 29830143
TI  - The Editor's Letter-Box.

PMID- 29830145
TI  - Medical Representation.

PMID- 29830146
TI  - Round the Hospitals.

PMID- 29830148
TI  - Notes of the Week.

PMID- 29830147
TI  - The Editor's Letter-Box.

PMID- 29830149
TI  - One Portal-with a Difference.

PMID- 29830151
TI  - Paying Patients in Poor-Law Infirmaries.

PMID- 29830150
TI  - The Royal Hospital for Incurables.

PMID- 29830152
TI  - The Draft Syllabus: Official Explanation.

PMID- 29830153
TI  - Alternative and Reciprocal Training.

PMID- 29830154
TI  - The Hospital Pageant.

PMID- 29830155
TI  - The National Children Adoption Association.

PMID- 29830156
TI  - "Qualified Nurses" and Their Qualifications.

PMID- 29830157
TI  - A "Revolting" Crime in Scotland.

PMID- 29830159
TI  - A Newcastle Programme.

PMID- 29830158
TI  - Is a Hospital Pageant Practicable?

PMID- 29830161
TI  - Some Public-Health Questions Discussed.

PMID- 29830160
TI  - Child Welfare at Brussels.

PMID- 29830162
TI  - The Hospital Debates.

PMID- 29830163
TI  - The Testamentary Habits of Legators.

PMID- 29830164
TI  - Diplomas in Radiography.

PMID- 29830165
TI  - Notes of the Week.

PMID- 29830166
TI  - How Co-Operation Must Begin.

PMID- 29830168
TI  - Round the Hospitals.

PMID- 29830167
TI  - Non-Residential Preliminary Schools.

PMID- 29830170
TI  - Parliament and the Professions.

PMID- 29830169
TI  - The New Territorial Force Nursing Service.

PMID- 29830172
TI  - Executive Committee Formed.

PMID- 29830171
TI  - The Record of an Active Year.

PMID- 29830173
TI  - A Feature of Recent Progress.

PMID- 29830174
TI  - The Derelict Child and the State.

PMID- 29830175
TI  - The International Union against Tuberculosis.

PMID- 29830176
TI  - Scotland and the College.

PMID- 29830178
TI  - The Census.

PMID- 29830177
TI  - Incipient Insanity and Home Life.

PMID- 29830179
TI  - The International Journal of Public Health.

PMID- 29830180
TI  - The Nile from the Point of View of Health.

PMID- 29830182
TI  - Ireland's Early Provision for the Sick.

PMID- 29830181
TI  - Registration of Fever Nurses.

PMID- 29830183
TI  - A University Diploma for Nurses.

PMID- 29830184
TI  - Welfare Work in Jeopardy.

PMID- 29830185
TI  - Medical Secrecy.

PMID- 29830186
TI  - Hospital Sunday Special Supplement.

PMID- 29830187
TI  - Nursing Diploma of the University of Leeds.

PMID- 29830188
TI  - Round the Hospitals.

PMID- 29830189
TI  - A New Light on Vitamines.

PMID- 29830190
TI  - Games for Girls.

PMID- 29830191
TI  - Notes of the Week.

PMID- 29830192
TI  - The Private Clinic System in Great Britain.

PMID- 29830194
TI  - Prevention of V.D.

PMID- 29830193
TI  - Dentistry and the Dentists Bill.

PMID- 29830195
TI  - Post-Graduate Medical Education.

PMID- 29830196
TI  - Their Uses and Manufacture.

PMID- 29830198
TI  - The Institutional Worker.

PMID- 29830197
TI  - The Value of the Little Hospitals.

PMID- 29830199
TI  - The Ministry of Health Bill.

PMID- 29830200
TI  - The General Nursing Council for England and Wales.

PMID- 29830201
TI  - A Clinic for Mothers.

PMID- 29830202
TI  - Queen Square.

PMID- 29830204
TI  - Parliament and the Professions.

PMID- 29830203
TI  - Should Nurses Smoke?

PMID- 29830206
TI  - The American Plan of Hospital Service.

PMID- 29830205
TI  - The New Health Act.

PMID- 29830207
TI  - The American Plan of Hospital Service.

PMID- 29830208
TI  - The Planning of Cottage Hospitals.

PMID- 29830210
TI  - Abdominal Pain in Children.

PMID- 29830209
TI  - India's Vital Statistics.

PMID- 29830211
TI  - Post-War "Nerves".

PMID- 29830212
TI  - Crime and Psycho-Analysis.

PMID- 29830214
TI  - More about Flogging.

PMID- 29830213
TI  - The Peril of the Pocket-Handkerchief.

PMID- 29830215
TI  - Scottish Matrons' Association.

PMID- 29830216
TI  - The Pay of the Nurse.-IV. The Ill-Effects of the Late Start in Life.

PMID- 29830218
TI  - A Physician's Anthology.

PMID- 29830217
TI  - Round the Hospitals.

PMID- 29830219
TI  - Notes of the Week.

PMID- 29830220
TI  - Headmistresses on Nursing as a Profession.

PMID- 29830221
TI  - Annual Meetings of Hospitals.

PMID- 29830222
TI  - Eye Injuries in Film Production.

PMID- 29830223
TI  - Hospital Conditions in London Sixty Years Ago.

PMID- 29830224
TI  - Past and Future Work.

PMID- 29830225
TI  - Scientific Massage versus Ineffectual Rubbing.

PMID- 29830227
TI  - The Limitations of Dentistry.

PMID- 29830226
TI  - Sister Tutors for Mental Hospitals.

PMID- 29830228
TI  - The Amended Syllabus of Nursing Education.

PMID- 29830229
TI  - Notes of the Week.

PMID- 29830230
TI  - The Panel Doctor.

PMID- 29830231
TI  - The Energy Values of Food.

PMID- 29830232
TI  - Health and Education in Yugo-Slavia.

PMID- 29830233
TI  - From Weekly Journal to Monthly Review.

PMID- 29830235
TI  - An Eighteenth-Century Hospital.

PMID- 29830234
TI  - Round the Hospitals.

PMID- 29830236
TI  - The Plight of a Bombay Hospital.

PMID- 29830237
TI  - Purifying Tidal Rivers.

PMID- 29830239
TI  - Insanity and Research.

PMID- 29830238
TI  - Grants for Nurse-Training Schools.

PMID- 29830241
TI  - The Cure and Control of Cancer.

PMID- 29830240
TI  - The Nursing Department in the Annual Report.

PMID- 29830243
TI  - A Year's Work of the Ministry of Health.

PMID- 29830242
TI  - A Note on Its Treatment and Prevalence.

PMID- 29830245
TI  - Lord Onslow and Local Committees.

PMID- 29830244
TI  - Diplomas in Radiography.

PMID- 29830247
TI  - Round the Hospitals.

PMID- 29830246
TI  - Notes of the Week.

PMID- 29830249
TI  - The Voluntary Hospitals Commission.

PMID- 29830248
TI  - Institutional Needs.

PMID- 29830251
TI  - Practical Points.

PMID- 29830250
TI  - Higher Charges for Distant Patients?

PMID- 29830252
TI  - Provisions Relating to Hospitals and Institutions.

PMID- 29830253
TI  - Work for Disabled Soldiers.

PMID- 29830254
TI  - Present Considerations and Future Outlook.

PMID- 29830255
TI  - The Question of Mass Contributions.

PMID- 29830256
TI  - Nurses' Registration Act, 1919.

PMID- 29830257
TI  - The Letters of a Layman.

PMID- 29830259
TI  - Doctors in the Witness-Box.

PMID- 29830258
TI  - A Necessary Part of Preventive Medicine.

PMID- 29830261
TI  - Parliament and the Professions.

PMID- 29830260
TI  - Round the Hospitals.

PMID- 29830263
TI  - The National Network of Nurses and Midwives.

PMID- 29830262
TI  - The Progress of Psycho-Analysis.

PMID- 29830264
TI  - Notes of the Week.

PMID- 29830265
TI  - The Sequel to the Mansion House Meeting.

PMID- 29830266
TI  - The Association of Hospital Matrons.

PMID- 29830267
TI  - More Letters of a Layman: A Postscript.

PMID- 29830269
TI  - War Pensions Administration.

PMID- 29830268
TI  - The Sister-Tutor as an Aid to Economy.

PMID- 29830270
TI  - A Layman's Letter Answered.

PMID- 29830272
TI  - The Conference on Child Welfare.

PMID- 29830271
TI  - The Period between School-Leaving and Hospital Training.

PMID- 29830273
TI  - Round the Hospitals.

PMID- 29830274
TI  - Health Problems in India.

PMID- 29830276
TI  - The Census Report.

PMID- 29830275
TI  - Modified Optimism.

PMID- 29830278
TI  - Hospital Treatment as an Additional Benefit.

PMID- 29830277
TI  - A Cheerful Report from Ipswich.

PMID- 29830280
TI  - Higher Charges for Distant Patients.

PMID- 29830279
TI  - Statistics and Conclusions.

PMID- 29830282
TI  - The Charity Organisation Society.

PMID- 29830281
TI  - Notes of the Week.

PMID- 29830283
TI  - Asylum Medical Work.

PMID- 29830284
TI  - A New Departure and a Valuable Analysis.

PMID- 29830285
TI  - Insanity Can Be Cured.

PMID- 29830286
TI  - The Prohibition Issue.

PMID- 29830288
TI  - Round the Hospitals.

PMID- 29830287
TI  - The Bonus Decrease.

PMID- 29830289
TI  - What the Peace Programme Has Done.

PMID- 29830290
TI  - The Battle of Jutland Film.

PMID- 29830291
TI  - Tuberculous Cripples.

PMID- 29830292
TI  - The Inspiration of Example.

PMID- 29830293
TI  - An Analysis of Seventy-Three Appeals.

PMID- 29830294
TI  - The National Provident Scheme.

PMID- 29830296
TI  - Economies and Sources of Income.

PMID- 29830295
TI  - Floors and Walls of Operating-Theatres.

PMID- 29830297
TI  - A Dream of Health.

PMID- 29830298
TI  - Notes of the Week.

PMID- 29830300
TI  - The Welfare of Migrants: World's Y.W.C.A. Report.

PMID- 29830299
TI  - Medical Manners and Mystery.

PMID- 29830301
TI  - Nurses as the Pioneer New Women.

PMID- 29830302
TI  - Rays from the Eye.

PMID- 29830303
TI  - The Mental Hospitals Association.

PMID- 29830304
TI  - The Metropolitan Asylums Board Report for 1920-21.

PMID- 29830306
TI  - Colonies for Mental Defectives.

PMID- 29830305
TI  - The Sites of Mental Hospitals.

PMID- 29830307
TI  - Parliament and the Professions.

PMID- 29830308
TI  - The Attitude of the Public.

PMID- 29830309
TI  - Qualifications and Study.

PMID- 29830310
TI  - Round the Hospitals.

PMID- 29830311
TI  - Health Administration by County Councils.

PMID- 29830312
TI  - Co-Ordination in Local Units.

PMID- 29830314
TI  - Publicity and Public Health.

PMID- 29830313
TI  - A County Tuberculosis Scheme.

PMID- 29830315
TI  - Diplomas in Radiography.

PMID- 29830316
TI  - A Mass of Interesting Detail.

PMID- 29830317
TI  - Women in Medicine.

PMID- 29830318
TI  - Notes of the Week.

PMID- 29830319
TI  - Prison Reform.

PMID- 29830320
TI  - The Scottish Syllabus.

PMID- 29830321
TI  - Nurses Entitled to Registration.

PMID- 29830322
TI  - How Do They Really Arise?

PMID- 29830323
TI  - To Readers of "The Hospital."

PMID- 29830324
TI  - Scotland's Care for Sanitary Science.

PMID- 29830325
TI  - Barrier Nursing in Fever Cases.

PMID- 29830326
TI  - Institutional Needs.

PMID- 29830328
TI  - Municipal Hospital and Clinical Benefits.

PMID- 29830327
TI  - The Hospital Position at Wakefield.

PMID- 29830329
TI  - Our Unvaccinated Population Steadily Increasing.

PMID- 29830330
TI  - Under Ideal Conditions.

PMID- 29830331
TI  - Planning the Autumn Campaign.

PMID- 29830332
TI  - Better Teaching in the Schools.

PMID- 29830333
TI  - Condition of the Patients.

PMID- 29830334
TI  - The Finances of Metropolitan Hospitals.

PMID- 29830335
TI  - Ringworm Clinics.

PMID- 29830336
TI  - An Encyclical from Charing Cross.

PMID- 29830338
TI  - Converting Coal-Burning Boiler Furnaces to Oil.

PMID- 29830337
TI  - Parliament and the Professions.

PMID- 29830339
TI  - Round the Hospitals.

PMID- 29830340
TI  - "Progress" and the Hospital Pageant.

PMID- 29830341
TI  - Notes of the Week.

PMID- 29830342
TI  - Suggested Methods of Development.

PMID- 29830343
TI  - An Exchange with "The Hospital."

PMID- 29830344
TI  - Unconscious Malingering in Childhood.

PMID- 29830346
TI  - Navy, Army, Air and Colonial Services.

PMID- 29830345
TI  - The Military and Civil Services.

PMID- 29830347
TI  - Cambridge University Course.

PMID- 29830348
TI  - The Medical Profession and the Public Well-Being.

PMID- 29830349
TI  - Medical Schools in the Provinces.

PMID- 29830350
TI  - Special Hospitals.

PMID- 29830351
TI  - Oxford University Course.

PMID- 29830352
TI  - Graduate Education and Institutions.

PMID- 29830353
TI  - The Medical Schools of the United Kingdom.

PMID- 29830354
TI  - A New Career for Medical Men.

PMID- 29830355
TI  - Research and the Medical Student.

PMID- 29830356
TI  - Medical Schools in Ireland.

PMID- 29830357
TI  - Inside the Asylum.

PMID- 29830358
TI  - Higher Diplomas.

PMID- 29830360
TI  - Medical Schools in Scotland.

PMID- 29830359
TI  - Parliament and the Professions.

PMID- 29830361
TI  - Notes of the Week.

PMID- 29830362
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29830363
TI  - Nursing under the Ministry of Health.

PMID- 29830364
TI  - The English Conjoint Course.

PMID- 29830366
TI  - Qualification and Registration.

PMID- 29830365
TI  - London University Course.

PMID- 29830367
TI  - Appendicitis.

PMID- 29830368
TI  - Construction Notes.

PMID- 29830369
TI  - Hospital Festivals and Meetings.

PMID- 29830370
TI  - Progress in Medicine.

PMID- 29830372
TI  - Water Pressure Accumulator.

PMID- 29830371
TI  - Notes and News.

PMID- 29830373
TI  - Case of Hysterical Knee.

PMID- 29830374
TI  - New Appliances and Things Medical.

PMID- 29830375
TI  - Ventro-Fixation of the Uterus.

PMID- 29830376
TI  - The New Institution for Epileptics in Berlin.

PMID- 29830377
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Inflammation of the Iris.

PMID- 29830379
TI  - Annotations.

PMID- 29830378
TI  - Some Later Herbalists.

PMID- 29830380
TI  - Practical Points.

PMID- 29830381
TI  - The Story of the Insane from Year to Year.

PMID- 29830382
TI  - The Hospital Nursing Supplement.

PMID- 29830383
TI  - The Chelsea Hospital for Women.

PMID- 29830384
TI  - The Power of the General Medical Council.

PMID- 29830385
TI  - Malignant Growths.

PMID- 29830387
TI  - Therapeutics and the Lesser Circulation: II.

PMID- 29830386
TI  - Walnut Lodge Hospital Hartford, Ct.

PMID- 29830388
TI  - Notes and News.

PMID- 29830389
TI  - Annotations.

PMID- 29830390
TI  - The Hospital Nursing Supplement.

PMID- 29830391
TI  - Where the Silky Cotton Grows.

PMID- 29830392
TI  - Progress in Medicine.

PMID- 29830393
TI  - Burning Questions.

PMID- 29830395
TI  - Hospital Festivals and Meetings.

PMID- 29830394
TI  - Progress in Surgery.

PMID- 29830397
TI  - On Hemiplegia.

PMID- 29830396
TI  - Bedsteads and Bedding.

PMID- 29830398
TI  - New Drugs and Preparations.

PMID- 29830399
TI  - Channels of Infection.

PMID- 29830400
TI  - Progress in Medicine.

PMID- 29830401
TI  - The Future of Serum Therapeutics.

PMID- 29830402
TI  - The Radcliffe Infirmary, Oxford.

PMID- 29830403
TI  - Chronic Catarrh of the Middle Ear: VI.-Treatment.

PMID- 29830404
TI  - The Genesis and Treatment of Hyperpyrexia.

PMID- 29830405
TI  - Unqualified Practice at Hospitals.

PMID- 29830406
TI  - Emigrants: Whence They Come and Where They Go.

PMID- 29830407
TI  - Hospital Festivals and Meetings.

PMID- 29830409
TI  - Progress in Surgery.

PMID- 29830408
TI  - Notes and News.

PMID- 29830410
TI  - Practical Departments.

PMID- 29830411
TI  - New Appliances and Things Medical.

PMID- 29830412
TI  - Great Northern Central Hospital.

PMID- 29830414
TI  - Annotations.

PMID- 29830413
TI  - The Hospital Nursing Supplement.

PMID- 29830415
TI  - The Story of the Insane from Year to Year.

PMID- 29830416
TI  - Bedsteads.

PMID- 29830417
TI  - Traumatic Ulnar Nerve Paralysis.-II.

PMID- 29830418
TI  - New Drugs and Appliances.

PMID- 29830419
TI  - Progress in Surgery.

PMID- 29830420
TI  - Cystitis.

PMID- 29830422
TI  - The Divorce between Medicine and Surgery.

PMID- 29830421
TI  - Construction Notes.

PMID- 29830423
TI  - Progress in Medicine.

PMID- 29830424
TI  - The Middlesex Hospital.

PMID- 29830425
TI  - Notes and News.

PMID- 29830426
TI  - Hypertrophy of the Prostrate.

PMID- 29830427
TI  - All Saints Convalescent Hospital, Eastbourne.

PMID- 29830428
TI  - Language and Race in Europe.

PMID- 29830429
TI  - The Library of the Good Huswife.

PMID- 29830430
TI  - The Hospital Nursing Supplement.

PMID- 29830432
TI  - Hospitals in Australia.

PMID- 29830431
TI  - Annotations.

PMID- 29830433
TI  - Annotations.

PMID- 29830434
TI  - Electric Lighting for Hospitals.

PMID- 29830435
TI  - Disease of the Heart and Vascular System.

PMID- 29830436
TI  - Practical Points.

PMID- 29830438
TI  - Progress in Surgery.

PMID- 29830437
TI  - The Field of Science.

PMID- 29830440
TI  - The "Red Chamber" Treatment of Small-Pox Patients.

PMID- 29830439
TI  - The New Craig House Asylum, Edinburgh.

PMID- 29830442
TI  - The Senile Heart.

PMID- 29830441
TI  - New Drugs and Preparations.

PMID- 29830443
TI  - Notes and News.

PMID- 29830444
TI  - New Appliances and Things Medical.

PMID- 29830445
TI  - Nurses' Home at Burmantofts (Leeds Union Infirmary).

PMID- 29830446
TI  - The Drug Treatment of Consumption.

PMID- 29830447
TI  - The Hospital Nursing Supplement.

PMID- 29830448
TI  - Periscope of Dermatology.

PMID- 29830449
TI  - On Toxic Neutralisations: III. Physiological Modification, or Catalysis.

PMID- 29830451
TI  - Around the Hospitals.

PMID- 29830450
TI  - On Toxic Neutralisations: II. Reconstitution.

PMID- 29830452
TI  - Hospital Sunday: Who Were Its Founders and Originators?

PMID- 29830453
TI  - The Story of the Insane from Year to Year.

PMID- 29830455
TI  - The Hospital Nursing Supplement.

PMID- 29830454
TI  - Injuries of Joints.

PMID- 29830457
TI  - Criminal Responsibility in the Insane.

PMID- 29830456
TI  - New Appliances and Things Medical.

PMID- 29830458
TI  - Domestic Economy.

PMID- 29830459
TI  - Notes on the Methods of Performing Paracentesis of the Various Cavities.

PMID- 29830461
TI  - Progress in Surgery.

PMID- 29830460
TI  - Annotations.

PMID- 29830463
TI  - The Kings of Spain.

PMID- 29830462
TI  - Notes and News.

PMID- 29830465
TI  - New Drugs and Preparations.

PMID- 29830464
TI  - Progress in Medicine.

PMID- 29830467
TI  - Around the Hospitals.

PMID- 29830466
TI  - Domestic Economy in Hospitals: A Reply to Mr. Ryan.

PMID- 29830468
TI  - Progress in Medicine.

PMID- 29830469
TI  - The Hospital Nursing Supplement.

PMID- 29830470
TI  - Progress in Surgery.

PMID- 29830471
TI  - The Czar's Illness and Its Lessons.

PMID- 29830472
TI  - Canadian Hospitals.

PMID- 29830473
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Iritis.

PMID- 29830474
TI  - Within the Hospitals.

PMID- 29830475
TI  - Notes and News.

PMID- 29830476
TI  - Chronic Catarrh of the Middle Ear.-V.

PMID- 29830477
TI  - Electric Lighting for Hospitals.

PMID- 29830478
TI  - Theories of Sanitation.

PMID- 29830479
TI  - Annotations.

PMID- 29830480
TI  - Albuminuria and Life Assurance.

PMID- 29830481
TI  - Progress in Medicine.

PMID- 29830482
TI  - Electric Lighting in Hospitals.

PMID- 29830484
TI  - Around the Hospitals.

PMID- 29830483
TI  - Conditions of Mental Enfeeblement.

PMID- 29830486
TI  - Sober by Act of Parliament.

PMID- 29830485
TI  - Ingrowing Toenail and Its Radical Cure.

PMID- 29830487
TI  - Construction Notes.

PMID- 29830488
TI  - A Visit to the Hospitals of Montreal-II.

PMID- 29830489
TI  - Progress in Surgery.

PMID- 29830490
TI  - Treatment of Perforation Peritonitis.

PMID- 29830491
TI  - The Hospital Nursing Supplement.

PMID- 29830492
TI  - The Harveian Oration.

PMID- 29830493
TI  - Notes and News.

PMID- 29830494
TI  - New Appliances and Things Medical.

PMID- 29830496
TI  - Cactus Grandiflorus: A Study in Therapeutics.

PMID- 29830495
TI  - Annotations.

PMID- 29830498
TI  - The Story of the Insane from Year to Year.

PMID- 29830497
TI  - Who Are We to Believe?

PMID- 29830500
TI  - New Appliances and Things Medical.

PMID- 29830499
TI  - Sir James Crichton Browne's Cure for Quackery.

PMID- 29830501
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Laminar Cataract.

PMID- 29830502
TI  - Hospital Construction.

PMID- 29830503
TI  - Progress in Surgery.

PMID- 29830505
TI  - Practical Departments.

PMID- 29830504
TI  - The Hospital Nursing Supplement.

PMID- 29830507
TI  - Hospital Meetings.

PMID- 29830506
TI  - Progress in Medicine.

PMID- 29830508
TI  - The Story of the Insane from Year to Year.

PMID- 29830509
TI  - Notes on the Methods of Performing Paracentesis of the Various Cavitives.

PMID- 29830510
TI  - The Opening of the Medical Schools.

PMID- 29830511
TI  - Passive Motion.

PMID- 29830513
TI  - Annotations.

PMID- 29830512
TI  - Notes and News.

PMID- 29830515
TI  - Editor's Letter-Box.

PMID- 29830514
TI  - Modern Medico-Psychology and Psychiatry: XII. Mental States of Alternation,
      Rhythm, and Periodicity.

PMID- 29830516
TI  - Periscope of Dermatology.

PMID- 29830517
TI  - The Value of Optic Neuritis in Medical Diagnosis.

PMID- 29830518
TI  - Domestic Economy in Hospitals.

PMID- 29830519
TI  - The Problem of the Poor in London.

PMID- 29830520
TI  - Annotations.

PMID- 29830521
TI  - Notes and News.

PMID- 29830522
TI  - The Hospital Nursing Supplement.

PMID- 29830524
TI  - Constuction Notes.

PMID- 29830523
TI  - Inheritance.

PMID- 29830525
TI  - Language and Race.

PMID- 29830526
TI  - Muscular Rheumatism.

PMID- 29830528
TI  - The "Red Chamber" Treatment of Small-Pox Patients.

PMID- 29830527
TI  - Progress in Medicine.

PMID- 29830529
TI  - The Pay System and the Profession.

PMID- 29830530
TI  - Devon and Exeter Hospital.

PMID- 29830531
TI  - Foreign Hospitals.

PMID- 29830532
TI  - Progress in Surgery.

PMID- 29830533
TI  - Practical Departments.

PMID- 29830534
TI  - Are Suicides Mad?

PMID- 29830536
TI  - Hospital Administration.

PMID- 29830535
TI  - New Drugs and Preparations.

PMID- 29830537
TI  - Annotations.

PMID- 29830538
TI  - Falmouth Cottage Hospital.

PMID- 29830540
TI  - The Hospital Nursing Supplement.

PMID- 29830539
TI  - Notes and News.

PMID- 29830541
TI  - The General Medical Council.

PMID- 29830542
TI  - Surgical Aid Society.

PMID- 29830543
TI  - Practical Points.

PMID- 29830544
TI  - On the Differential Diagnosis of Swellings in the Neck.-I.

PMID- 29830545
TI  - In the Law Courts.

PMID- 29830547
TI  - Tumours of the Breast.

PMID- 29830546
TI  - Diseases of the Nervous System.

PMID- 29830549
TI  - Medical and Hospital Progress at Oxford.

PMID- 29830548
TI  - On Modern Progress in Ophthalmic Medicine: Iritis.

PMID- 29830551
TI  - Theory of the Universal Medicine.

PMID- 29830550
TI  - The Pathology of Carcinoma.

PMID- 29830553
TI  - The Great Northern Central's Pay Wards.

PMID- 29830552
TI  - Radcliffe Infirmary, Oxford.

PMID- 29830554
TI  - The Anti-Toxin Treatment of Diphtheria.

PMID- 29830555
TI  - The Hospital Nursing Supplement.

PMID- 29830556
TI  - Notes and News.

PMID- 29830557
TI  - Poisoning from Subnitrate of Bismuth.

PMID- 29830558
TI  - Children's Cots.

PMID- 29830559
TI  - Annotations.

PMID- 29830560
TI  - The Radcliffe Infirmary, Oxford.

PMID- 29830561
TI  - The Financial Strength of Our Voluntary Charities.

PMID- 29830562
TI  - Diseases of the Liver.

PMID- 29830563
TI  - General Surgery.

PMID- 29830565
TI  - Construction Notes.

PMID- 29830564
TI  - Annus Medicus, 1894.

PMID- 29830566
TI  - Diphtheritic Paralysis in Children.

PMID- 29830567
TI  - Hospital Construction.

PMID- 29830568
TI  - Practical Departments.

PMID- 29830569
TI  - New Appliances and Things Medical.

PMID- 29830570
TI  - Traumatic Ulnar Nerve Paralysis.-I.

PMID- 29830571
TI  - The Medical Inspection of Schools.

PMID- 29830572
TI  - The Early Diagnosis of Cancer of the Rectum.

PMID- 29830574
TI  - Notes and News.

PMID- 29830573
TI  - Diseases of the Nervous System.

PMID- 29830576
TI  - Construction Notes.

PMID- 29830575
TI  - Around the Hospitals.

PMID- 29830578
TI  - Hospital Meetings.

PMID- 29830577
TI  - Annotations.

PMID- 29830580
TI  - Practical Points.

PMID- 29830579
TI  - Toxicological Memoranda.

PMID- 29830581
TI  - An Episcopal Surgeon.

PMID- 29830582
TI  - Therapeutics and the Lesser Circulation: I. Preliminary Considerations.

PMID- 29830584
TI  - The Hospital Nursing Supplement.

PMID- 29830583
TI  - Surgery of the Liver and Gall Bladder.

PMID- 29830585
TI  - Radcliffe Infirmary, Oxford.

PMID- 29830587
TI  - Intestinal Diseases.

PMID- 29830586
TI  - Some Causes of Febrile Disturbance in Women during the Lying-In Period.

PMID- 29830589
TI  - Cranial Surgery.

PMID- 29830588
TI  - Annotations.

PMID- 29830590
TI  - Ferratin.

PMID- 29830591
TI  - The Story of the Insane from Year to Year.

PMID- 29830593
TI  - Construction Notes.

PMID- 29830592
TI  - Poplar Hospital for Accidents.

PMID- 29830595
TI  - A Typhoid Fever Bath.

PMID- 29830594
TI  - The Financial Strength of Our Voluntary Charities.

PMID- 29830596
TI  - Diphtheritic Paralysis in Children.

PMID- 29830597
TI  - Around the Hospitals.

PMID- 29830598
TI  - Conculcation or Inoculation?

PMID- 29830599
TI  - Gold.

PMID- 29830600
TI  - The Early Symptoms of General Paralysis.

PMID- 29830602
TI  - The Hospital Nursing Supplement.

PMID- 29830601
TI  - Modern Medico-Psychology and Psychiatry: States of Defective Inhibition and of
      Uncontrollable Impulse.

PMID- 29830603
TI  - Notes and News.

PMID- 29830604
TI  - Spinal Surgery.

PMID- 29830606
TI  - Renal Surgery.

PMID- 29830605
TI  - The Financial Strength of Our Voluntary Charities.

PMID- 29830608
TI  - Hospital Festivals and Meetings.

PMID- 29830607
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29830609
TI  - Diseases of Children.

PMID- 29830610
TI  - New Appliances and Things Medical.

PMID- 29830611
TI  - Education and Disease.

PMID- 29830612
TI  - The Medical Congress at Calcutta.

PMID- 29830613
TI  - The Problem of the Poor.

PMID- 29830614
TI  - Post Office and the Work of the Blind.

PMID- 29830615
TI  - Rectal Surgery.

PMID- 29830616
TI  - Adventures of a Tenth Century Medical Student.

PMID- 29830617
TI  - Notes and News.

PMID- 29830618
TI  - Hospital Construction: The Rotunda Hospital, Dublin.

PMID- 29830619
TI  - Annotations.

PMID- 29830620
TI  - The Radcliffe Infirmary.

PMID- 29830621
TI  - The Hospital Nursing Supplement.

PMID- 29830622
TI  - Practical Points.

PMID- 29830624
TI  - Annotations.

PMID- 29830623
TI  - The Great Northern Central Hospital.

PMID- 29830625
TI  - The Study of Man.

PMID- 29830626
TI  - Nervous Diseases and Modern Life.

PMID- 29830629
TI  - Boarding Schools as Disseminators of Disease.

PMID- 29830627
TI  - Hospital Festivals and Meetings.

PMID- 29830630
TI  - The Ethical in Modern Medicine.

PMID- 29830631
TI  - The Hospital Nursing Supplement.

PMID- 29830633
TI  - Neuritis and Neuralgia.

PMID- 29830632
TI  - Notes and News.

PMID- 29830634
TI  - On Some Minor Anal and Rectal Ailments-II.

PMID- 29830636
TI  - Paying Patients in General Hospitals.

PMID- 29830635
TI  - Progress in Medicine.

PMID- 29830637
TI  - New Appliances and Things Medical.

PMID- 29830638
TI  - The Treatment of Chronic Cystitis.

PMID- 29830640
TI  - Portable Fire Escape.

PMID- 29830639
TI  - The Plague of Consumption.

PMID- 29830641
TI  - Hospital Festivals and Meetings.

PMID- 29830642
TI  - The Story of the Insane from Year to Year.

PMID- 29830643
TI  - Notes and News.

PMID- 29830644
TI  - The Medical Care of Idiots, Imbeciles, and Feeble-Minded Children.

PMID- 29830645
TI  - Annotations.

PMID- 29830646
TI  - Progress in Medicine.

PMID- 29830647
TI  - The Dangers of Electricity.

PMID- 29830648
TI  - Progress in Surgery.

PMID- 29830649
TI  - Is Insanity Increasing in Scotland?

PMID- 29830651
TI  - The Hospital Nursing Supplement.

PMID- 29830650
TI  - Origin and Classification of Aneurisms.

PMID- 29830652
TI  - Pay Wards in General Hospitals.

PMID- 29830653
TI  - Construction Notes.

PMID- 29830655
TI  - The Alice Memorial and the Nethersole Hospitals, Hong Kong.

PMID- 29830654
TI  - Progress in Surgery.

PMID- 29830656
TI  - New Drugs and Preparations.

PMID- 29830657
TI  - Notes and News.

PMID- 29830658
TI  - The Story of the Insane from Year to Year.

PMID- 29830659
TI  - A Teaching University: A New Hope for London Medicine.

PMID- 29830660
TI  - The Hospital Nursing Supplement.

PMID- 29830661
TI  - Progress in Medicine.

PMID- 29830662
TI  - Around the Hospitals.

PMID- 29830663
TI  - The Case for the Eight Hours Day.

PMID- 29830665
TI  - Modern Medico-Psychology and Psychiatry.

PMID- 29830664
TI  - Hospital Administration.

PMID- 29830666
TI  - The Indian Medical Congress at Calcutta-The Fevers of India-The National Health
      Society.

PMID- 29830667
TI  - Hospital Festivals and Meetings.

PMID- 29830668
TI  - The Lettsomian Lectures.

PMID- 29830669
TI  - Malignant Disease of the Spine.

PMID- 29830670
TI  - Progress in Ophthalmology.

PMID- 29830671
TI  - Annotations.

PMID- 29830672
TI  - New Appliances and Things Medical.

PMID- 29830673
TI  - Epilepsy and Paralysis.

PMID- 29830674
TI  - Notes and News.

PMID- 29830676
TI  - Annotations.

PMID- 29830675
TI  - A Medical Duel.

PMID- 29830678
TI  - Miscellaneous, &c.

PMID- 29830677
TI  - The Hospital Nursing Supplement.

PMID- 29830679
TI  - Consumption.

PMID- 29830680
TI  - Insanity and Inoculation.

PMID- 29830681
TI  - Lying-In.

PMID- 29830682
TI  - Modern Medico-Psychology and Psychiatry: XIII.-States of Defective Control and of
      Morbid and Uncontrollable Impulse.

PMID- 29830683
TI  - A Few Other Charities.

PMID- 29830684
TI  - The Flowing Tide of Christmas Charity.

PMID- 29830685
TI  - The Treatment of Migraine.

PMID- 29830686
TI  - Gastrostomy.

PMID- 29830687
TI  - On the Differential Diagnosis of Swellings in the Neck.

PMID- 29830688
TI  - Children.

PMID- 29830689
TI  - Women.

PMID- 29830690
TI  - General Hospitals.

PMID- 29830691
TI  - Communism or Christianity?: A Story of the Future.

PMID- 29830693
TI  - Progress in Medicine.

PMID- 29830692
TI  - The Disposal and Treatment of the Insane.

PMID- 29830694
TI  - The Reports of Hospitals.

PMID- 29830695
TI  - Assistant Physicians to Provincial Infirmaries.

PMID- 29830696
TI  - Foreign Hospitals.

PMID- 29830697
TI  - Notes and News.

PMID- 29830699
TI  - Progress in Ophthalmology.

PMID- 29830698
TI  - Practical Departments.

PMID- 29830701
TI  - The Metropolitan Asylums Board and the Anti-Toxin Treatment.

PMID- 29830700
TI  - Head Injuries.

PMID- 29830702
TI  - Hospital Festivals and Meetings.

PMID- 29830703
TI  - The Story of the Insane from Year to Year.

PMID- 29830705
TI  - New Drugs and Preparations.

PMID- 29830704
TI  - Tracheotomy.

PMID- 29830707
TI  - The Hospital Nursing Supplement.

PMID- 29830706
TI  - Annotations.

PMID- 29830709
TI  - Decorative Art.

PMID- 29830708
TI  - The Planning of Hospitals.

PMID- 29830710
TI  - Hospital Sunday Amenities.

PMID- 29830711
TI  - Progress in Surgery.

PMID- 29830712
TI  - New Appliances and Things Medical.

PMID- 29830713
TI  - Infective Diseases.

PMID- 29830714
TI  - Notes and News.

PMID- 29830715
TI  - Wound Infection.

PMID- 29830716
TI  - New Eye Infirmary, Sunderland.

PMID- 29830717
TI  - Club Foot: Its Nature and Treatment.

PMID- 29830719
TI  - The Hospital Nursing Supplement.

PMID- 29830718
TI  - A Deadly Disease of Our Own Times.

PMID- 29830721
TI  - Hospital Festivals and Meetings.

PMID- 29830720
TI  - The Livingstone Cottage Hospital, Dartford.

PMID- 29830723
TI  - Heating and Ventilation.

PMID- 29830722
TI  - Progress in Dermatology.

PMID- 29830724
TI  - Modern Medico-Psychology and Psychiatry: States of Fixed Delusion.

PMID- 29830726
TI  - New Appliances and Things Medical.

PMID- 29830725
TI  - Hernia. II.

PMID- 29830727
TI  - The Derbyshire Royal Infirmary.

PMID- 29830728
TI  - Tar.

PMID- 29830729
TI  - Annotations.

PMID- 29830730
TI  - Therapeutics and the Lesser Circulation.

PMID- 29830731
TI  - Hospital Festivals and Meetings.

PMID- 29830732
TI  - Professional Infamy: The Medical Council and the Obstetrical Society.

PMID- 29830734
TI  - The Financial Strength of Our Voluntary Charities.

PMID- 29830733
TI  - New Drugs and Preparations.

PMID- 29830735
TI  - Medical News from India.

PMID- 29830736
TI  - General Hospitals and Infectious Cases.

PMID- 29830737
TI  - Some Imperfections of Medical Education.

PMID- 29830738
TI  - Heredity in Consumption.

PMID- 29830740
TI  - Progress in Medicine.

PMID- 29830739
TI  - Skin Grafting and Allied Procedures.

PMID- 29830741
TI  - Annotations.

PMID- 29830742
TI  - The Hospital Nursing Supplement.

PMID- 29830743
TI  - Progress in Surgery.

PMID- 29830744
TI  - Notes and News.

PMID- 29830747
TI  - Children's Cots.

PMID- 29830745
TI  - Rain Baths.

PMID- 29830748
TI  - Hospital Festivals and Meetings.

PMID- 29830749
TI  - Miss Shannon and the Grantham Infirmary.

PMID- 29830751
TI  - The Hospital Nursing Supplement.

PMID- 29830750
TI  - Boarding Schools as Disseminators of Disease.

PMID- 29830752
TI  - Localised OEdema.

PMID- 29830753
TI  - Progress in Gynaecology.

PMID- 29830754
TI  - Progress in Surgery.

PMID- 29830755
TI  - Darwinism and Race Progress.

PMID- 29830756
TI  - The Noises of Great Cities.

PMID- 29830757
TI  - New Appliances and Things Medical.

PMID- 29830758
TI  - The Livingstone Cottage Hospital, Dartford.

PMID- 29830759
TI  - Micro-Organisms of Sewage.

PMID- 29830760
TI  - Cottage Hospitals and General Practitioners.

PMID- 29830762
TI  - Annotations.

PMID- 29830761
TI  - Notes and News.

PMID- 29830763
TI  - Derbyshire Royal Infirmary.

PMID- 29830764
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Diseases of the Cornea.

PMID- 29830766
TI  - The Price of the Publican.

PMID- 29830765
TI  - Barrack Schools as Fever Hospitals!

PMID- 29830768
TI  - The Perils of the Post.

PMID- 29830767
TI  - Hernia.

PMID- 29830769
TI  - Dry Sanitation.

PMID- 29830770
TI  - New Appliances and Things Medical.

PMID- 29830772
TI  - Hospital Festivals and Meetings.

PMID- 29830771
TI  - On Some Minor Anal and Rectal Ailments.-I.

PMID- 29830773
TI  - Vaginal Douching.

PMID- 29830774
TI  - The Hospital Nursing Supplement.

PMID- 29830776
TI  - Notes and News.

PMID- 29830775
TI  - Special Hospitals: Robbers of the Poor.

PMID- 29830778
TI  - Isolation Hospitals as Centres of Infection.

PMID- 29830777
TI  - The Hospital Locker.

PMID- 29830780
TI  - The Midwifery Muddle.

PMID- 29830779
TI  - Paying Patients at the Great Northern Central Hospital.

PMID- 29830781
TI  - Progress in Dermatology.

PMID- 29830782
TI  - Treatment and the Pulmonary Circulation: IV.

PMID- 29830783
TI  - Annotations.

PMID- 29830785
TI  - Progress in Surgery.

PMID- 29830786
TI  - Chronic Cerebral Abscess.

PMID- 29830787
TI  - Hospital Festivals and Meetings.

PMID- 29830788
TI  - The Planning of Fever Hospitals.

PMID- 29830789
TI  - The Devon and Exeter Hospital.

PMID- 29830790
TI  - New Appliances and Things Medical.

PMID- 29830791
TI  - Heating and Ventilation.

PMID- 29830793
TI  - Facts about Families.

PMID- 29830792
TI  - Workshops and Drink.

PMID- 29830794
TI  - The Vaccination Question.

PMID- 29830795
TI  - The Hospital Nursing Supplement.

PMID- 29830796
TI  - Progress in Medicine.

PMID- 29830797
TI  - Treatment and the Pulmonary Circulation.

PMID- 29830798
TI  - Annotations.

PMID- 29830799
TI  - Notes and News.

PMID- 29830800
TI  - The Story of the Insane from Year to Year.

PMID- 29830802
TI  - Dr. Klein on Antitoxin.

PMID- 29830801
TI  - Practical Points.

PMID- 29830803
TI  - The Vaccination Question.

PMID- 29830804
TI  - Hospital Finance.

PMID- 29830805
TI  - Annotations.

PMID- 29830806
TI  - Notes and News.

PMID- 29830807
TI  - Society and the Beggar.

PMID- 29830808
TI  - Hospital Festivals and Meetings.

PMID- 29830809
TI  - Manchester Royal Infirmary.

PMID- 29830810
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29830812
TI  - The Definition of Puerperal Fever.

PMID- 29830811
TI  - Otology.

PMID- 29830814
TI  - The Plague of 1167.

PMID- 29830813
TI  - Devon and Exeter Hospital.

PMID- 29830815
TI  - The Hospital Nursing Supplement.

PMID- 29830816
TI  - Aneurism.

PMID- 29830817
TI  - Infective Diseases.

PMID- 29830818
TI  - New Appliances and Things Medical.

PMID- 29830819
TI  - Health by Act of Parliament.

PMID- 29830820
TI  - The Holloway Sanatorium Inquiry.

PMID- 29830822
TI  - Annotations.

PMID- 29830821
TI  - New Appliances and Things Medical: The "Compactum" Midwifery Case.

PMID- 29830823
TI  - Notes and News.

PMID- 29830824
TI  - Wry-Neck.

PMID- 29830826
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29830825
TI  - Plastic or Fibrinous Bronchitis: With Notes of a Case.

PMID- 29830827
TI  - Surgery of the Stomach.

PMID- 29830828
TI  - A Medical Programme.

PMID- 29830829
TI  - Operative Treatment of Tuberculous Joint Diseases.

PMID- 29830830
TI  - The Field of Science.

PMID- 29830831
TI  - Pulmonary Tuberculosis: General Therapeutics.

PMID- 29830832
TI  - The Making of American Doctors.

PMID- 29830833
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29830835
TI  - Notes on Cases of Necrosis of the Lower Jaw in Children.

PMID- 29830834
TI  - The McLean Hospital, Waverley, Mass., U.S.A.

PMID- 29830837
TI  - Agathin.

PMID- 29830836
TI  - The Royal Hospital for Incurables.

PMID- 29830838
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29830840
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29830839
TI  - Midwives Registration Association.

PMID- 29830842
TI  - Disease of the Vermiform Appendix.

PMID- 29830841
TI  - Endowments.

PMID- 29830843
TI  - Around the Hospitals.

PMID- 29830844
TI  - Annotations.

PMID- 29830845
TI  - Thyroid Feeding in Skin Diseases.

PMID- 29830846
TI  - Imperial Typhoid: The Unemployed.

PMID- 29830847
TI  - Art and Disease: III. Modified Forms of Possession.

PMID- 29830848
TI  - The History and Capabilities of Herbal Simples: Goose-Grass.

PMID- 29830849
TI  - Modern Medico-Psychology and Psychiatry: I.-Introductory.

PMID- 29830850
TI  - Notes and News.

PMID- 29830851
TI  - Chlaralose.

PMID- 29830852
TI  - The Story of the Insane from Year to Year.

PMID- 29830853
TI  - A Munificent Gift.

PMID- 29830854
TI  - Appliances at Poplar.

PMID- 29830855
TI  - The Drainage of Wounds and Cavities.

PMID- 29830856
TI  - Haemoptysis.

PMID- 29830857
TI  - The Hospital Saturday Fund.

PMID- 29830859
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29830858
TI  - Diphtheria : Some Points in the Pathology and Treatment.

PMID- 29830861
TI  - Art and Disease: VI. Healing of the Sick.

PMID- 29830860
TI  - Three Provincial Hospitals: Alnwick Infirmary.

PMID- 29830863
TI  - The Field of Science.

PMID- 29830862
TI  - The Red Cross Ambulance.

PMID- 29830864
TI  - The Preparation of Patients for Operation.

PMID- 29830865
TI  - The Opium Problem.

PMID- 29830866
TI  - Voluntary Support.

PMID- 29830867
TI  - The Stockport Infirmary.

PMID- 29830868
TI  - The Minds of Nations.

PMID- 29830869
TI  - Cancer of the Cervix Uteri.

PMID- 29830870
TI  - Notes and News.

PMID- 29830871
TI  - Progress in Surgery.

PMID- 29830873
TI  - The Shipwrecked Fishermen and Mariners' Benevolent Society.

PMID- 29830872
TI  - Annotations.

PMID- 29830874
TI  - Around the Hospitals.

PMID- 29830875
TI  - The Sir Titus Salt Hospital.

PMID- 29830876
TI  - Is Darwinism a Dying Faith?

PMID- 29830877
TI  - Medical Progress.

PMID- 29830878
TI  - Hospital Meetings.

PMID- 29830879
TI  - New Appliances and Things Medical.

PMID- 29830880
TI  - Art and Disease: A Solution Offered.

PMID- 29830882
TI  - Annotations.

PMID- 29830881
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29830883
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29830884
TI  - The Field of Science.

PMID- 29830885
TI  - Origin and Development.

PMID- 29830886
TI  - Animal Temperature under Narcotics.

PMID- 29830887
TI  - Pulmonary Diseases: Pneumonia.

PMID- 29830888
TI  - Ventilation and Ventilators.

PMID- 29830890
TI  - Hospital Festivals and Meetings.

PMID- 29830889
TI  - New Hospitals v. The Extension of Existing Hospitals in London.

PMID- 29830891
TI  - The Royal Alfred Aged Merchant Seamen's Institution.

PMID- 29830892
TI  - Diphtheria, Scarlet Fever, and Sore Throat.

PMID- 29830894
TI  - New Appliances and Things Medical: Patent "Ozonised" Digestive Tea-Food Florador
      "Champetier de Ribes" Bags.

PMID- 29830893
TI  - Art and Disease: IV. Artistic Deformity.

PMID- 29830896
TI  - Notes and News.

PMID- 29830895
TI  - Acute Infective Periostitis in Children: Its Causation and Treatment.

PMID- 29830897
TI  - Surgery of Intestines.

PMID- 29830898
TI  - Erratum: Hospital Week at Northampton.
AB  - [This corrects the article on p. 272a in vol. 15.].

PMID- 29830900
TI  - Hydrastinine and Calcium Chloride.

PMID- 29830899
TI  - The Cochin Hospital, Paris.

PMID- 29830901
TI  - The Opium Problem.

PMID- 29830902
TI  - Insomnia: Its Causes and Treatment.

PMID- 29830903
TI  - On the Treatment of Rupture of Urethra.

PMID- 29830904
TI  - Bristol General Hospital.

PMID- 29830905
TI  - Empyema of the Antrum.

PMID- 29830907
TI  - Hospital Festivals, Meetings, &c.

PMID- 29830906
TI  - The Field of Science.

PMID- 29830909
TI  - Insanity and Its Kinships.

PMID- 29830908
TI  - Notes and News.

PMID- 29830910
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29830911
TI  - The Story of the Insane from Year to Year.

PMID- 29830912
TI  - Annotations.

PMID- 29830913
TI  - New Drugs and Preparations.

PMID- 29830914
TI  - Diseases of the Tonsils.

PMID- 29830915
TI  - Tubercular Peritonitis, &c.

PMID- 29830916
TI  - Nerve Diseases.

PMID- 29830917
TI  - New Appliances and Things Medical.

PMID- 29830918
TI  - Drugs and Their Uses.

PMID- 29830919
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29830920
TI  - Around the Hospitals.

PMID- 29830921
TI  - Art and Disease: VII. Aspects of Death.

PMID- 29830923
TI  - Construction Notes.

PMID- 29830922
TI  - Medical Progress.

PMID- 29830924
TI  - New Drugs and Preparations.

PMID- 29830926
TI  - Progress in Surgery.

PMID- 29830925
TI  - Diuretin and Diuresis-The Theoretical Side.

PMID- 29830927
TI  - The Corpus Sanum.

PMID- 29830928
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29830929
TI  - The Health of the Navy.

PMID- 29830930
TI  - The Treatment of Disease by Animal Extracts.

PMID- 29830931
TI  - The Story of the Insane from Year to Year.

PMID- 29830932
TI  - Around the Hospitals.

PMID- 29830933
TI  - West Ham, Stratford, and South Essex Hospital.

PMID- 29830934
TI  - New Appliances and Things Medical.

PMID- 29830936
TI  - Practical Aspects of Medical Science.

PMID- 29830935
TI  - Hospital Festivals and Meetings.

PMID- 29830938
TI  - The Electrolytic Treatment of Hirsuties and of Trichiasis.

PMID- 29830937
TI  - Notes and News.

PMID- 29830940
TI  - Modern Methods of Treatment of Simple Fractures.

PMID- 29830939
TI  - Practical Departments.

PMID- 29830942
TI  - Around the Hospitals.

PMID- 29830941
TI  - Annotations.

PMID- 29830943
TI  - Should Civilization Suppress Quackery?

PMID- 29830944
TI  - Modern Methods of Treatment of Compound Fracture.

PMID- 29830946
TI  - New Appliances and Things Medical: Kingzett's Improved Sulphur Fumigating
      Candles.

PMID- 29830945
TI  - Trional and Tetronal.

PMID- 29830947
TI  - New Hospitals v. Hospital Extension for London: II.-Station Hospitals.

PMID- 29830948
TI  - The Field of Science.

PMID- 29830949
TI  - Hospital Festivals and Meetings.

PMID- 29830950
TI  - Ward Fittings at Middlesex Hospital.

PMID- 29830951
TI  - Medical Progress.

PMID- 29830952
TI  - Professor Unna's Gelatines.

PMID- 29830953
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29830954
TI  - Progress in Surgery.

PMID- 29830955
TI  - Construction Notes.

PMID- 29830956
TI  - Art and Disease: V. The Lame and the Blind.

PMID- 29830957
TI  - Modern Aspects of Pernicious Anaemia.

PMID- 29830958
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29830959
TI  - The Story of the Insane from Year to Year.

PMID- 29830961
TI  - Notes and News.

PMID- 29830960
TI  - Inflamed Eyes.

PMID- 29830962
TI  - Annotations.

PMID- 29830963
TI  - Diseases of Children.

PMID- 29830965
TI  - Around the Hospitals.

PMID- 29830964
TI  - Leaderless Medicine.

PMID- 29830967
TI  - The Field of Science.

PMID- 29830966
TI  - Empyema of the Antrum.

PMID- 29830969
TI  - New Drugs and Preparations.

PMID- 29830968
TI  - Temperature and Anaesthesia.

PMID- 29830971
TI  - Hospital Festivals, Meetings, &c.

PMID- 29830970
TI  - Edinburgh Royal Infirmary.

PMID- 29830973
TI  - Art and Disease: VIII. In the National Gallery.

PMID- 29830972
TI  - Practical Aspects of Medical Science.

PMID- 29830975
TI  - Annotations.

PMID- 29830974
TI  - Notes and News.

PMID- 29830977
TI  - Aberdeen and Its Institutions.

PMID- 29830976
TI  - New Appliances and Things Medical.

PMID- 29830979
TI  - Asthma.

PMID- 29830978
TI  - The Red Cross Ambulance.

PMID- 29830980
TI  - Modern Aspects of the Treatment of Graves' Disease.

PMID- 29830981
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29830983
TI  - Practical Departments.

PMID- 29830982
TI  - Wrexham Infirmary.

PMID- 29830984
TI  - Liver and Gall Bladder.

PMID- 29830985
TI  - Hospital Abuse and the Working Class.

PMID- 29830986
TI  - Notes and News.

PMID- 29830987
TI  - Diseases of the Brain Due to Diseases of the Ear.

PMID- 29830988
TI  - Construction Notes: Tooting Fever Hospital.

PMID- 29830989
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29830990
TI  - Salophen.

PMID- 29830991
TI  - A Plaster Bed in the Treatment of Pott's Disease.

PMID- 29830992
TI  - Appliances at Poplar.

PMID- 29830993
TI  - New Appliances and Things Medical: Germ White Bread.

PMID- 29830994
TI  - The Serum and Antitoxin Treatment of Tetanus.

PMID- 29830996
TI  - Annotations.

PMID- 29830995
TI  - Midwives Registration Association.

PMID- 29830998
TI  - Pulmonary Tuberculosis.

PMID- 29830997
TI  - Ophthalmology.

PMID- 29830999
TI  - Art and Disease: II. Possession or Hysteria.

PMID- 29831000
TI  - Treatment of Poisoning by Chloral Hydrate.

PMID- 29831001
TI  - Sir Andrew Clark: A Monument.

PMID- 29831002
TI  - The Field of Science.

PMID- 29831004
TI  - The Poor in London.

PMID- 29831003
TI  - Around the Hospitals.

PMID- 29831006
TI  - The Magdalen Hospital, Streatham.

PMID- 29831005
TI  - Drainage in Surgical Treatment.

PMID- 29831008
TI  - Annotations.

PMID- 29831007
TI  - Modern Aspects of Pain in Medicine. II.

PMID- 29831009
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831010
TI  - Notes and News.

PMID- 29831011
TI  - Borax and Bromides in Epilepsy.

PMID- 29831012
TI  - The Straight Position in Injuries of the Elbow-Joint.

PMID- 29831013
TI  - The Field of Science.

PMID- 29831014
TI  - The Medical Work of the Local Government Board: IV. Locality and Disease.

PMID- 29831015
TI  - Sir Andrew Clark.

PMID- 29831016
TI  - King's College Hospital.

PMID- 29831018
TI  - New Appliances and Things Medical: Carbolic Disinfectants -Glenfield's
      Disinfecting and Cleansing Fluid-Borax Preparations.

PMID- 29831017
TI  - The Treatment of Myxoedema.

PMID- 29831019
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29831021
TI  - Cottage Hospital Construction.

PMID- 29831020
TI  - The Story of the Insane from Year to Year.

PMID- 29831022
TI  - New Home for Incurables, Newcastle-On-Tyne.

PMID- 29831023
TI  - Glass-Topped Locker.

PMID- 29831024
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831025
TI  - The London Hospital New Buildings.

PMID- 29831026
TI  - Around the Hospitals.

PMID- 29831027
TI  - St. George's Hospital.

PMID- 29831028
TI  - Notes and News.

PMID- 29831029
TI  - The Treatment of Erysipelas.

PMID- 29831031
TI  - Annotations.

PMID- 29831030
TI  - Object and Scope.

PMID- 29831032
TI  - The Treatment of Pneumonia.

PMID- 29831033
TI  - Uric Acid Solvents in Gout and Gravel.

PMID- 29831034
TI  - A Learned Profession.

PMID- 29831035
TI  - Modern Biology: III. On the Minute Structure of Cells.

PMID- 29831037
TI  - The Field of Science.

PMID- 29831036
TI  - Middlesex Hospital.

PMID- 29831039
TI  - New Appliances and Things Medical: The Improved Clinical Chart Block and Case.

PMID- 29831038
TI  - Therapeutics in Diphtheria.

PMID- 29831040
TI  - Some Metropolitan, Provincial, Scotch, and Irish Special Hospitals Compared.

PMID- 29831041
TI  - Cruelty in Irish Parents.

PMID- 29831042
TI  - The Field of Science.

PMID- 29831043
TI  - On the Cellular Structure of Living Organisms.-II.

PMID- 29831044
TI  - Hospitals in India: I. The Bengal Presidency (4).

PMID- 29831045
TI  - The Medical Work of the Local Government Board: The Incidence of Disease and
      Sanitation.

PMID- 29831046
TI  - The General Infirmary, Leeds.

PMID- 29831047
TI  - The General Hospital, Birmingham.

PMID- 29831048
TI  - Annotations.

PMID- 29831049
TI  - Some Dangers Attending the Use of the Rectangular Position in Injuries of the
      Elbow-Joint.

PMID- 29831051
TI  - Notes and News.

PMID- 29831050
TI  - Injection of Hydrogen Peroxide into the Peritoneal Cavity.

PMID- 29831053
TI  - Construction Notes.

PMID- 29831052
TI  - Washstands.

PMID- 29831054
TI  - Consultants and General Practitioners.

PMID- 29831055
TI  - The Treatment of Hare Lip.

PMID- 29831056
TI  - Borax and Bromides in Epilepsy.

PMID- 29831057
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831058
TI  - West Ham Hospital, Stratford, E.

PMID- 29831059
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831060
TI  - The Field of Science.

PMID- 29831061
TI  - Construction Notes.

PMID- 29831062
TI  - Notes and News.

PMID- 29831063
TI  - The Radical Cure of Hernia.

PMID- 29831064
TI  - The Story of the Insane from Year to Year.

PMID- 29831065
TI  - Treatment of Dilated Stomach.

PMID- 29831066
TI  - The Uniform System of Accounts for Hospitals and Institutions.

PMID- 29831067
TI  - Nurses' Home, Edinburgh Royal Infirmary.

PMID- 29831068
TI  - Modern Aspects of Appendicitis.-I.

PMID- 29831069
TI  - New Appliances and Things Medical: Scotch Oatmeal.

PMID- 29831070
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29831072
TI  - The "Quarterly Review" on Hospitals.

PMID- 29831071
TI  - Annotations.

PMID- 29831073
TI  - Around the Hospitals.

PMID- 29831074
TI  - Some Remarks on Hernia.

PMID- 29831075
TI  - The Medical Work of the Local Government Board: V. Diphtheria and Infective
      Endocarditis.

PMID- 29831076
TI  - Westminster Hospital Students' Dinner.

PMID- 29831077
TI  - Anniversary Meeting of the Salop Infirmary.

PMID- 29831078
TI  - Uric Acid Solvents in Gout and Gravel.

PMID- 29831080
TI  - Empirical and Chemical Theories.

PMID- 29831079
TI  - British Home for Incurables, Clapham.

PMID- 29831082
TI  - The Treatment of Ringworm at Bristol General Hospital and Elsewhere.

PMID- 29831081
TI  - Asylums in India: IV. The Central Provinces.

PMID- 29831084
TI  - Contemporary Theory and Research.

PMID- 29831083
TI  - Notes and News.

PMID- 29831085
TI  - On the Cellular Structure of Living Organisms. I.

PMID- 29831086
TI  - The Medical Work of the Local Government Board: Vaccination.

PMID- 29831088
TI  - Hospital Saturday and Street Collections.

PMID- 29831087
TI  - Law, Medicine, and Humanity.

PMID- 29831089
TI  - Provincial, Scotch, and Irish Hospitals.

PMID- 29831090
TI  - Annotations.

PMID- 29831091
TI  - On the Treatment of Aural Suppuration. II.-The Chronic Form.

PMID- 29831093
TI  - The Treatment of Erysipelas.

PMID- 29831092
TI  - New Home for Incurables, Newcastle-On-Tyne.

PMID- 29831094
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831095
TI  - Pirated Inventions.

PMID- 29831097
TI  - Treatment of Hip-Joint Disease.

PMID- 29831096
TI  - East London Hospital for Children, and Dispensary for Women.

PMID- 29831098
TI  - Village Poor and London Hospitals.

PMID- 29831099
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831100
TI  - Steam Disinfector.

PMID- 29831101
TI  - Thirty-Fifth Annual Report of the Commissioners in Lunacy for Scotland.

PMID- 29831102
TI  - Disease of Dietetic Origin.

PMID- 29831103
TI  - The Field of Science.

PMID- 29831104
TI  - Infectious Disease Hospitals in London.

PMID- 29831107
TI  - Notes and News.

PMID- 29831106
TI  - Construction Notes.

PMID- 29831105
TI  - Around the Hospitals.

PMID- 29831108
TI  - On Oxygen Administration.

PMID- 29831109
TI  - Free or Sober?

PMID- 29831110
TI  - Democracy and the Hospitals.

PMID- 29831111
TI  - The Medical Defence Union and the London and Counties Medical Protection Society.

PMID- 29831112
TI  - Lavage of the Intestinal Tube.

PMID- 29831113
TI  - Annotations.

PMID- 29831114
TI  - Hospitals in India: I. The Bengal Presidency (5).

PMID- 29831115
TI  - Modern Aspects of Inflammation.

PMID- 29831116
TI  - Consumption.

PMID- 29831117
TI  - Notes and News.

PMID- 29831118
TI  - Women.

PMID- 29831119
TI  - Christmas Cheer.

PMID- 29831120
TI  - Children.

PMID- 29831121
TI  - General Hospitals.

PMID- 29831122
TI  - Epilepsy and Paralysis.

PMID- 29831124
TI  - Figures That Feel and Work.

PMID- 29831123
TI  - A Few Other Charities.

PMID- 29831126
TI  - Miscellaneous-Special.

PMID- 29831125
TI  - Annotations.

PMID- 29831128
TI  - Lying-In.

PMID- 29831127
TI  - England and Her Christmas.

PMID- 29831129
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29831131
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831130
TI  - Nature and Treatment of Flat Foot.

PMID- 29831132
TI  - Around the Hospitals.

PMID- 29831133
TI  - Medical Defence Union and the London and Counties Medical Protection Society
      (Limited).

PMID- 29831134
TI  - Chorea.

PMID- 29831135
TI  - Treatment of Diphtheria.

PMID- 29831136
TI  - The Royal Hospital for Incurables.

PMID- 29831137
TI  - Construction Notes.

PMID- 29831138
TI  - Diseases of the Brain Due to Diseases of the Ear.

PMID- 29831140
TI  - Hospitals in India: I. The Bengal Presidency (6).

PMID- 29831139
TI  - Famous Poisoners in Fiction: VIII. Poisoner and Physician.

PMID- 29831141
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831142
TI  - The Story of the Insane from Year to Year.

PMID- 29831143
TI  - Notes and News.

PMID- 29831144
TI  - Window Ventilation in Sick Rooms.

PMID- 29831145
TI  - The Field of Science.

PMID- 29831146
TI  - Report on Leprosy and the Trinidad Leper Asylum for 1892.

PMID- 29831147
TI  - New Appliances and Things Medical: Almond Pound Cake.

PMID- 29831148
TI  - Annotations.

PMID- 29831149
TI  - Ars Longa.

PMID- 29831150
TI  - The Infection of Phthisis.

PMID- 29831151
TI  - Modern Anthropology.

PMID- 29831152
TI  - Other People's Children.

PMID- 29831153
TI  - Annotations.

PMID- 29831154
TI  - Modes of Administering Oxygen.

PMID- 29831155
TI  - Ophthalmology: On Blepharitis, Its Causes and Treatment.

PMID- 29831156
TI  - Abdominal Surgery.

PMID- 29831157
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831159
TI  - Construction Notes.

PMID- 29831158
TI  - Spasm in the Diagnosis of Acute Meningitis in Children.

PMID- 29831160
TI  - Sources of Hospital Revenne.

PMID- 29831161
TI  - Art and Disease: I. Possession or Hysteria.

PMID- 29831162
TI  - Practical Departments: Appliances at Poplar Hospital.

PMID- 29831163
TI  - Notes and News.

PMID- 29831164
TI  - Hospitals in India: I. The Bengal Presidency (7).

PMID- 29831165
TI  - Injury as a Factor in the Production of New Growths of Bone.

PMID- 29831166
TI  - Sanitary Deficiences and Puerperal Diseases.

PMID- 29831167
TI  - Annus Medicus: 1893.

PMID- 29831168
TI  - Pleurisy.

PMID- 29831169
TI  - Some Scotch Asylums.

PMID- 29831170
TI  - Case of Tubercular Peritonitis Complicated by Periosteal Abscess of the Thigh
      Laparotomy-Recovery.

PMID- 29831172
TI  - Annotations.

PMID- 29831171
TI  - Treatment of Contraction of the Fingers.

PMID- 29831173
TI  - The Field of Science.

PMID- 29831174
TI  - The Royal Hospital for Incurables.

PMID- 29831175
TI  - Notes and News.

PMID- 29831176
TI  - Hospital Convalescent Home, Parkwood, Swanley, Kent.

PMID- 29831177
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831178
TI  - Construction Notes.

PMID- 29831179
TI  - Modern Biology: IV. Cell Division.

PMID- 29831180
TI  - Ward Cupboards.-I. Medicine Cupboards.

PMID- 29831181
TI  - Recent Uses of Thyroid Preparations.

PMID- 29831182
TI  - The Medical Work of the Local Government Board: VI. Inoculation and
      Insusceptibility.

PMID- 29831183
TI  - The Treatment of Acute Maniacal Delirium: Means Directed to Relieve the Acute
      Symptoms and the Subsequent Treatment.

PMID- 29831184
TI  - The East London Hospital for Children.

PMID- 29831185
TI  - Medical Protection and Defence.

PMID- 29831186
TI  - The Metropolitan Hospital Sunday Fund.

PMID- 29831187
TI  - Royal Hospital for Incurables.

PMID- 29831188
TI  - Inhalation of Oxygen for Therapeutical Purposes.

PMID- 29831189
TI  - Hospital Convalescent Home, Parkwood, Swanley, Kent.

PMID- 29831191
TI  - The Field of Science.

PMID- 29831190
TI  - The Medical Defence Union and the London and Counties Medical Protection Society
      (Limited).

PMID- 29831192
TI  - The Medical Defence Union and the London and Counties Medical Protection Society
      (Limited).

PMID- 29831194
TI  - Modern Aspects of Appendicitis. II.

PMID- 29831193
TI  - Treatment of Erysipelas.

PMID- 29831195
TI  - Notes and News.

PMID- 29831196
TI  - Annotations.

PMID- 29831198
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29831197
TI  - First Studies in Anthropology.

PMID- 29831199
TI  - Mattei Remedies and Cure for Drunkenness.

PMID- 29831200
TI  - The Surgical Aid Society.

PMID- 29831201
TI  - Salicylic Acid for Preserving.

PMID- 29831202
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831203
TI  - The Treatment of Acute Maniacal Delerium: Means Directed to Relieve the Acute
      Symptoms and the Subsequent Treatment.

PMID- 29831204
TI  - Construction Notes.

PMID- 29831206
TI  - An Anxious Succession.

PMID- 29831205
TI  - Around the Hospitals.

PMID- 29831207
TI  - Military and Naval Hospitals.

PMID- 29831208
TI  - New Appliances and Things Medical.

PMID- 29831210
TI  - The London Dental Hospital Students' Dinner.

PMID- 29831209
TI  - The London Hospital.

PMID- 29831211
TI  - Newcastle Royal Infirmary.

PMID- 29831213
TI  - Notes and News.

PMID- 29831212
TI  - The Formation of Uric Acid and Its Effects on the System.

PMID- 29831214
TI  - The Treatment of Post-Partum Haemorrhage.

PMID- 29831215
TI  - Inguinal Colotomy in Carcinoma of the Rectum.

PMID- 29831217
TI  - Great Achievements under Suffering: V. Leopold, Duke of Albany.

PMID- 29831216
TI  - Medical Protection for School Morals.

PMID- 29831218
TI  - Treatment of Chloroform Collapse.

PMID- 29831219
TI  - On the Diagnostic Value of the Degree of Acidity of the Gastric Juice.

PMID- 29831220
TI  - Tetanus.

PMID- 29831222
TI  - New Appliances and Things Medical.

PMID- 29831221
TI  - Typhoid.

PMID- 29831223
TI  - Around the Hospitals.

PMID- 29831224
TI  - Construction Notes.

PMID- 29831225
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831226
TI  - Modern Medico-Psychology and Psychiatry: II.-Legislative and State Measures and
      Their Effects.

PMID- 29831227
TI  - Hospital Festivals, Meetings, &c.

PMID- 29831228
TI  - Annotations.

PMID- 29831229
TI  - Around the Hospitals.

PMID- 29831230
TI  - Annotations.

PMID- 29831232
TI  - New Appliances and Things Medical.

PMID- 29831231
TI  - London Ambulance: "Benefits Forgot".

PMID- 29831233
TI  - Hospital Festivals, Meetings, &c.

PMID- 29831234
TI  - Edinburgh Royal Infirmary-Treatment of Acute Rheumatism.

PMID- 29831235
TI  - A Case of Neuroma of the External Popliteal Nerve.

PMID- 29831237
TI  - The Poor and the Poor Law.

PMID- 29831236
TI  - On Modern Progress of Ophthalmic Medicine and Surgery.

PMID- 29831238
TI  - Malaria.

PMID- 29831239
TI  - Notes and News.

PMID- 29831241
TI  - Construction Notes.

PMID- 29831240
TI  - Rhinology.

PMID- 29831242
TI  - Practical Departments.

PMID- 29831243
TI  - The Field of Science.

PMID- 29831244
TI  - Voluntary Offerings.

PMID- 29831245
TI  - The Educational Treatment of Idiots. Imbeciles, and Feeble-Minded Children.

PMID- 29831246
TI  - The Treatment of Pneumonia.

PMID- 29831247
TI  - New Drugs and Preparations: Caffeine.

PMID- 29831248
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831250
TI  - Annotations.

PMID- 29831249
TI  - Caries of the Spine.

PMID- 29831251
TI  - Modern Aspects of Diabetes.

PMID- 29831252
TI  - Around the Hospitals.

PMID- 29831253
TI  - Construction Notes.

PMID- 29831254
TI  - Notes and News.

PMID- 29831255
TI  - Mr. T. Holmes on John Hunter.

PMID- 29831256
TI  - Hospital Administration.

PMID- 29831257
TI  - Cost of Administration.-Hospitals for Consumption.

PMID- 29831258
TI  - Ingrowing Toe-nail: II. Treatment.

PMID- 29831259
TI  - Famous Poisoners in Fiction: VII. The Child of Crime.

PMID- 29831260
TI  - New Bed Rest.

PMID- 29831261
TI  - The London and Counties Medical Protection Society.

PMID- 29831262
TI  - The Treatment of Naevi.

PMID- 29831263
TI  - St. Thomas's Hospital: Presentation to Dr. Bristowe.

PMID- 29831264
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831265
TI  - The Microscope in Relation to Modern Biology.

PMID- 29831266
TI  - Poultice Warmer and Inhaler.

PMID- 29831267
TI  - The Field of Science.

PMID- 29831269
TI  - The Lunacy Blue Book.

PMID- 29831268
TI  - The Use and Administration of Creasote.

PMID- 29831271
TI  - A New Method of Treating the Insane.

PMID- 29831270
TI  - The Royal Free Hospital.

PMID- 29831272
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831273
TI  - Special Hospitals: VI. Miscellaneous. Cost of Management.

PMID- 29831275
TI  - Annotations.

PMID- 29831274
TI  - Around the Hospitals.

PMID- 29831276
TI  - Who Creates Criminal Children?

PMID- 29831277
TI  - Notes and News.

PMID- 29831278
TI  - A Case for Medical Discipline.

PMID- 29831279
TI  - The Treatment of Ringworm at Bristol General Hospital and Elsewhere.

PMID- 29831281
TI  - Some Modern Aspects of Diabetes. II.

PMID- 29831280
TI  - Instrument Table.

PMID- 29831282
TI  - The Dead or the Living?

PMID- 29831283
TI  - Construction Notes.

PMID- 29831285
TI  - Cocaine in Ophthalmic Work.

PMID- 29831284
TI  - On the Treatment of Otorrhoea in the Aural Department.

PMID- 29831286
TI  - Around the Hospitals.

PMID- 29831287
TI  - The Treatment of the Summer Diarrhoea of Children.

PMID- 29831288
TI  - Notes and News.

PMID- 29831289
TI  - The Story of the Insane from Year to Year.

PMID- 29831290
TI  - Mr. Henry Dobbin.

PMID- 29831291
TI  - Many Internal Improvements.

PMID- 29831292
TI  - Annotations.

PMID- 29831293
TI  - Modern Aspects of Pain in Medicine.

PMID- 29831294
TI  - Death Certification and Murder.

PMID- 29831295
TI  - The Medical Work of the Local Government Board: The Manure Conundrum.

PMID- 29831296
TI  - On the Treatment of Otorrhoea in the Aural Department. III.

PMID- 29831297
TI  - The History and Capabilities of Herbal Simples: Good King Henry.

PMID- 29831298
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831299
TI  - Gas Stove.

PMID- 29831300
TI  - Hospitals in India: I. The Bengal Presidency (3).

PMID- 29831301
TI  - The Poplar Hospital.

PMID- 29831302
TI  - The Field of Science.

PMID- 29831304
TI  - Annotations.

PMID- 29831303
TI  - The Treatment of Empyema.

PMID- 29831305
TI  - Diseases of the Tonsils.

PMID- 29831306
TI  - Surgery of the Genito-Urinary Organs.

PMID- 29831307
TI  - New Appliances and Things Medical.

PMID- 29831308
TI  - Medical Ideals Unrealised.

PMID- 29831310
TI  - Diuretin and Diuretics-Practical.

PMID- 29831309
TI  - Royal Infirmary, Bristol.

PMID- 29831312
TI  - Hospital Festivals, Meetings, &c.

PMID- 29831311
TI  - Scientific Temperance.

PMID- 29831314
TI  - Around the Hospitals.

PMID- 29831313
TI  - Who Invented Vaccination?

PMID- 29831315
TI  - Some General Considerations as to the Various Methods of Treatment to Be Adopted
      in Skin Affections.

PMID- 29831316
TI  - Modern Aspects of Pernicious Anaemia.-II.

PMID- 29831317
TI  - Notes and News.

PMID- 29831319
TI  - Practical Departments.

PMID- 29831318
TI  - Painful Menstruation and Its Treatment.

PMID- 29831321
TI  - Perchloride of Mercury.

PMID- 29831320
TI  - Practical Aspects of Medical Science.

PMID- 29831322
TI  - Extra Supplement.-The Nursing Mirror.

PMID- 29831323
TI  - Vaccination in India.

PMID- 29831324
TI  - Nerve Disease.

PMID- 29831325
TI  - Methylacetanilide.

PMID- 29831327
TI  - The Value of a Time-Table.

PMID- 29831326
TI  - The Medical Profession and National Service.

PMID- 29831328
TI  - Hospital and Institutional News.

PMID- 29831329
TI  - The War and Our Supply of Drugs.

PMID- 29831331
TI  - From across the Seas.

PMID- 29831330
TI  - The Psychology of Fear: the Effects of Panic Fear in Wartime.

PMID- 29831332
TI  - Round the Hospitals.

PMID- 29831333
TI  - Some War Problems in Food: II. Meat Rations for the Staff.

PMID- 29831335
TI  - Parliament and the Profession.

PMID- 29831334
TI  - The Problem of Poor-Law Infirmaries: The Workhouse Influence.

PMID- 29831337
TI  - The Royal Gwent Hospital, Newport, Mon.

PMID- 29831336
TI  - The Institutional Worker.

PMID- 29831338
TI  - Flavine: the Ideal Antiseptic.

PMID- 29831339
TI  - Insane Soldiers and the Law.

PMID- 29831340
TI  - A Century of Rebuilding at Leeds.

PMID- 29831341
TI  - Eminent Chairman Series: V. Mr. Charles Lupton.

PMID- 29831343
TI  - A Defender of the Profession.

PMID- 29831342
TI  - A Rough Day on the Upper Kennet.

PMID- 29831344
TI  - Institutional Notes and News.

PMID- 29831345
TI  - A Note on the Prophylactic Value of Sclavo's Serum.

PMID- 29831346
TI  - The Week's Work.

PMID- 29831348
TI  - Parliament and Publications.

PMID- 29831347
TI  - Rosenmuller's Fossa and the Middle Ear.

PMID- 29831350
TI  - The Hospital World.

PMID- 29831349
TI  - Annotations.

PMID- 29831351
TI  - Adrenalin in Asthma.

PMID- 29831352
TI  - Conditions in Non-Phthisical Patients Suggesting Tuberculosis of the Lungs.

PMID- 29831354
TI  - Medical Opinion and Movement.

PMID- 29831353
TI  - The League of Mercy and Contributions from Hospital Funds to Medical Schools.

PMID- 29831355
TI  - News and Events of the Week.

PMID- 29831356
TI  - New Appliances & Things Medical.

PMID- 29831358
TI  - "The Hospital" Medico-Sociological Supplement (No. II).

PMID- 29831357
TI  - Anaphylaxis.

PMID- 29831359
TI  - An Appeal for a Change of Tactics.

PMID- 29831360
TI  - Annotations.

PMID- 29831361
TI  - Medical Opinion and Movement.

PMID- 29831362
TI  - News and Events of the Week.

PMID- 29831363
TI  - A Little-Known Form of "Cold Abscess."

PMID- 29831364
TI  - Institutional Notes and News.

PMID- 29831365
TI  - Medical Sociology.

PMID- 29831366
TI  - The Sanatorium Village.

PMID- 29831367
TI  - The Week's Work.

PMID- 29831368
TI  - Eminent Chairman Series : IV. Mr. James Gadesden Wainwright, J.P.

PMID- 29831369
TI  - A Central Medical School for New York.

PMID- 29831370
TI  - The Hospital World.

PMID- 29831371
TI  - The Klapp Treatment of Scoliosis.

PMID- 29831373
TI  - The Operative Treatment of Fractures.

PMID- 29831372
TI  - Drug Eruptions: Their Nature and Varieties-II.

PMID- 29831374
TI  - Royal Southern Hospital, Liverpool.

PMID- 29831376
TI  - Progress in Dermatology.

PMID- 29831375
TI  - "The Hospital" Medico-Sociological Supplement (No. I).

PMID- 29831377
TI  - Progress in Cerebral, Spinal, and Nerve Surgery.

PMID- 29831378
TI  - Ascending Renal Infection.

PMID- 29831379
TI  - Muscular Atrophy and Sclerodermia.

PMID- 29831380
TI  - Tetanus Treated by Injections of Antitoxin into the Spinal Theca.

PMID- 29831381
TI  - Removal of King's College Hospital.

PMID- 29831382
TI  - Notes and News.

PMID- 29831383
TI  - League of Mercy.

PMID- 29831384
TI  - The Etiology of Alopecia Areata.

PMID- 29831385
TI  - The Hospital. Nursing Section.

PMID- 29831386
TI  - New Appliances and Things Medical.

PMID- 29831387
TI  - Insurance against Surgical Operations.

PMID- 29831388
TI  - The Physical Signs of Lobar Pneumonia.

PMID- 29831389
TI  - Progress in Pediatrics.

PMID- 29831390
TI  - Annotations.

PMID- 29831392
TI  - Re-Vaccination.

PMID- 29831391
TI  - Hospital Meetings.

PMID- 29831393
TI  - Annotations.

PMID- 29831394
TI  - Diet in Disease: II-Food and Food Values.

PMID- 29831395
TI  - The Treatment of Chronic Constipation.

PMID- 29831396
TI  - Notes and News.

PMID- 29831398
TI  - The New Isolated Building at the "Oresund Hospital," Copenhagen.

PMID- 29831397
TI  - Everybody's Page.

PMID- 29831399
TI  - Aberdeen and Its Institutions.

PMID- 29831400
TI  - Special Hospitals-Lying in and Women.

PMID- 29831401
TI  - Treatment of Rheumatoid Arthritis.

PMID- 29831402
TI  - A Plea for the "Practical" Man.

PMID- 29831404
TI  - The Hospital Nursing Supplement.

PMID- 29831403
TI  - Medical History from the Earliest Times: XXVI.-The Eclectics and Compilers.

PMID- 29831405
TI  - Employments for Women: IV. Lecturing for the County Councils.

PMID- 29831406
TI  - The Cost of Trained Nurses.

PMID- 29831407
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29831408
TI  - Magic Cures.

PMID- 29831409
TI  - Cooking by Gas. III: Private Households.

PMID- 29831410
TI  - The General Infirmary, Northampton.

PMID- 29831411
TI  - The Hospital Nursing Supplement.

PMID- 29831413
TI  - Annotations.

PMID- 29831412
TI  - Medical History from the Earliest Times: XXXIX.-The Arabo-Scholastic Revival. (2)
      Surgery.

PMID- 29831415
TI  - The Use of Spermina.

PMID- 29831414
TI  - Everybody's Page.

PMID- 29831416
TI  - In the Abstract.

PMID- 29831417
TI  - On the Treatment of Knock Knee.

PMID- 29831418
TI  - A New Use for Telepathy.

PMID- 29831419
TI  - Treatment of Tuberculous Glands.

PMID- 29831421
TI  - Notes and News.

PMID- 29831420
TI  - Pasteur and Jenner.

PMID- 29831423
TI  - The Story of the Insane from Year to Year.

PMID- 29831422
TI  - Treatment of Acute Pneumonia.

PMID- 29831425
TI  - Around the Hospitals.

PMID- 29831424
TI  - Mr. Chamberlain on Friendly Workers.

PMID- 29831426
TI  - Too Few Frenchmen.

PMID- 29831427
TI  - The Treatment of Chorea.

PMID- 29831428
TI  - The Hospital Nursing Supplement.

PMID- 29831429
TI  - Treatment of Fracture of the Patella.

PMID- 29831431
TI  - A Wise Resolve.

PMID- 29831430
TI  - The Efficacy of Vaccination.

PMID- 29831432
TI  - The Laundry.

PMID- 29831433
TI  - Medical History from the Earliest Times: XXV.-Nestorian Medical Schools.

PMID- 29831435
TI  - Special Hospitals-Children.

PMID- 29831434
TI  - An Account of the North Kensington Friendly Workers among the Poor.

PMID- 29831436
TI  - Annotations.

PMID- 29831437
TI  - Diet in Disease: I. Food and Food Values.

PMID- 29831438
TI  - The Treatment of the Dropsy of Bright's Disease.

PMID- 29831439
TI  - The Miraculous Cures of Lourdes.

PMID- 29831440
TI  - The Attitude of Great Writers Towards Disease: XII. Dumas on the Art of the
      Poisoner.

PMID- 29831441
TI  - The Public School-Boy's Body.

PMID- 29831442
TI  - Notes and News.

PMID- 29831443
TI  - Church of England Sanitary Association.

PMID- 29831444
TI  - The Children's Hospital. Great Ormend Street.

PMID- 29831446
TI  - The Marquis of Salisbury at Oxford.

PMID- 29831445
TI  - Overstrained Brains : A Cry for More Institutions.

PMID- 29831447
TI  - Medical History from the Earliest Times: XLVI.-The Mystics, Sympathy, and
      Signatures.

PMID- 29831448
TI  - Treatment of the Bowel in Operations for Strangulated Hernia.

PMID- 29831449
TI  - Pensions for Old Age: I. Three Schemes Considered.

PMID- 29831450
TI  - Notes and News.

PMID- 29831451
TI  - Around the Hospitals.

PMID- 29831452
TI  - The Hospital Nursing Supplement.

PMID- 29831453
TI  - Hospitals of the World: I. Early Hospitals in Europe.

PMID- 29831454
TI  - Annotations.

PMID- 29831455
TI  - Everybody's Page.

PMID- 29831456
TI  - The Treatment of Fractures of the Femur.

PMID- 29831457
TI  - Diet in Disease: XV.-Diabetes.

PMID- 29831458
TI  - Treatment of Pleurisy.

PMID- 29831459
TI  - Everybody's Page.

PMID- 29831461
TI  - Opening of the Royal Eye Hospital, Southwark.

PMID- 29831460
TI  - The Hospital Nursing Supplement.

PMID- 29831462
TI  - Medical History from the Earliest Times: XXXVIII.-The Arabo-Scholastic Revival.
      (1) Medicine.

PMID- 29831463
TI  - Cooking by Gas. II.

PMID- 29831464
TI  - The Chemistry and Therapeutics of Gout.

PMID- 29831465
TI  - Annotations.

PMID- 29831466
TI  - The Treatment of Tonsillitis.

PMID- 29831467
TI  - Water Supply and Waste.

PMID- 29831468
TI  - Notes and News.

PMID- 29831469
TI  - The Treatment of Gastric Ulcer.

PMID- 29831470
TI  - Construction Notes.

PMID- 29831471
TI  - Taken on Trust.

PMID- 29831473
TI  - The Warneford Hospital, Leamington.

PMID- 29831472
TI  - The Treatment of Strumous Disease of the Knee-Joint.

PMID- 29831475
TI  - Literary Intelligence.

PMID- 29831474
TI  - The Feeding of Girls at Schools.

PMID- 29831476
TI  - Bedford and Its Medical Institutions.

PMID- 29831477
TI  - Margarine Adulteration.

PMID- 29831478
TI  - Asylums in India: I. The Bombay Presidency.

PMID- 29831480
TI  - Everybody's Page.

PMID- 29831479
TI  - Annotations.

PMID- 29831481
TI  - The Mildmay Medical Mission Hospital, Austin Street, Shoreditch.

PMID- 29831482
TI  - The Treatment of Hernia.

PMID- 29831483
TI  - The Recognition of Scientific Research.

PMID- 29831484
TI  - The Attitude of Great Writers Towards Disease: XX. The Plague at Milan, 1630.

PMID- 29831486
TI  - Construction Notes.

PMID- 29831485
TI  - The Hospital Nursing Supplement.

PMID- 29831488
TI  - Naphthalin as a Sedative.

PMID- 29831487
TI  - Medical History from the Earliest Times: XLI.-Mediaeval Military Medicine.

PMID- 29831490
TI  - New Drugs, Appliances, and Things Medical: The Newton-Nixon Thermometer Case.

PMID- 29831489
TI  - Treatment of Pott's Fracture.

PMID- 29831491
TI  - Royal Medical Benevolent College.

PMID- 29831492
TI  - The Beginnings of Disease.

PMID- 29831493
TI  - Notes and News.

PMID- 29831494
TI  - The Treatment of Strangulated Hernia.

PMID- 29831495
TI  - Notes and News.

PMID- 29831497
TI  - Construction Notes.

PMID- 29831496
TI  - The Durham County Hospital.

PMID- 29831498
TI  - Empyema.

PMID- 29831499
TI  - Hospital Uncharity.

PMID- 29831500
TI  - The Parson and the Public House.

PMID- 29831501
TI  - The Hospital Nursing Supplement.

PMID- 29831503
TI  - Treatment of Typhoid Fever.

PMID- 29831502
TI  - Annotations.

PMID- 29831504
TI  - Lying-In Hospital at Helsingfors. Finland.

PMID- 29831505
TI  - The Story of the Insane from Year to Year.

PMID- 29831506
TI  - Contemporary Theory and Research.

PMID- 29831507
TI  - Operative Treatment of Mucous Polypi of the Nose.

PMID- 29831508
TI  - Asylums in India: III. The Bengal Presidency.

PMID- 29831509
TI  - Medical History from the Earliest Times: XLIII.-The Medical Profession in the
      Middle Ages.

PMID- 29831511
TI  - Everybody's Page.

PMID- 29831510
TI  - Huddersfield Infirmary.

PMID- 29831512
TI  - Research-A Challenge to the Press.

PMID- 29831513
TI  - The Treatment of Conjunctivitis.

PMID- 29831514
TI  - The Progress and Policy of the Hospitals Association.

PMID- 29831515
TI  - New Drugs, Appliances, and Things Medical: An Admirable Hot-Water Bottle.

PMID- 29831516
TI  - Hypnotism for the Insane.

PMID- 29831517
TI  - Treatment of Dilatation of the Stomach.

PMID- 29831519
TI  - The Hospital Nursing Supplement.

PMID- 29831518
TI  - Annotations.

PMID- 29831521
TI  - Magic Cures II.

PMID- 29831520
TI  - The Treatment of Hip Disease.

PMID- 29831523
TI  - The Treatment of Hip Joint Disease.

PMID- 29831522
TI  - A Central Hospitals Board for London.

PMID- 29831524
TI  - Dermographism.

PMID- 29831525
TI  - No Quarantine.

PMID- 29831526
TI  - Hospitals and Asylums of the World.

PMID- 29831528
TI  - The Picture Magazine.

PMID- 29831527
TI  - Medical History from the Earliest Times: XL.-The Close of the Middle Ages.

PMID- 29831530
TI  - Hypnotism and Drunkenness.

PMID- 29831529
TI  - The International Congress of Charities, Correction, and Philanthropy, June 12
      18, 1893: Section Four on the Hospital Care of the Sick, the Training of Nurses,
      Dispensary Work, and First Aid to the Injured.

PMID- 29831531
TI  - Cooking by Gas. IV.

PMID- 29831532
TI  - Everybody's Page.

PMID- 29831533
TI  - Notes and News.

PMID- 29831534
TI  - The Treatment of Pott's Fracture.

PMID- 29831535
TI  - Annotations.

PMID- 29831536
TI  - The Poor of London and Their Medical Needs.

PMID- 29831537
TI  - Treatment of Purulent Conjunctivitis.

PMID- 29831538
TI  - The Virchow Banquet.

PMID- 29831539
TI  - Construction Notes.

PMID- 29831540
TI  - The Treatment of Pneumonia.

PMID- 29831541
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29831542
TI  - Radcliffe Infirmary, Oxford.

PMID- 29831543
TI  - Kitchen Ranges and Stoves.

PMID- 29831544
TI  - The Home Hospitals Association.

PMID- 29831545
TI  - Diet in Disease: XVII.-Gout.

PMID- 29831546
TI  - Hospital and Staff Liability for Negligence.

PMID- 29831547
TI  - Notes and News.

PMID- 29831549
TI  - Hospitals of the World: III. The Progress of English Nursing.

PMID- 29831548
TI  - The Hospital Nursing Supplement.

PMID- 29831550
TI  - Treatment of Pleurisy.

PMID- 29831551
TI  - Contemporary Theory and Research.

PMID- 29831552
TI  - The Treatment of Gastric Ulcer.

PMID- 29831553
TI  - Construction Notes.

PMID- 29831554
TI  - The Treatment of Rickets.

PMID- 29831555
TI  - Prehistoric Trepanning.

PMID- 29831556
TI  - The Hospital Nursing Supplement.

PMID- 29831557
TI  - Medical History from the Earliest Times: XLIV.-Unprofessional Medicine in the
      Middle Ages.

PMID- 29831559
TI  - Waste Products.

PMID- 29831558
TI  - The Institute of Preventive Medicine.

PMID- 29831561
TI  - Hypnal or Monochloral-Antipyrin.

PMID- 29831560
TI  - The Story of the Insane from Year to Year.

PMID- 29831562
TI  - The Mildmay Mission Hospital.

PMID- 29831563
TI  - Everybody's Page.

PMID- 29831564
TI  - The Cumberland Infirmary, Carlisle.

PMID- 29831565
TI  - Progress in Bacteriology.

PMID- 29831566
TI  - Notes and News.

PMID- 29831567
TI  - Treatment of Otorrhoea (Discharge from the Ear).

PMID- 29831568
TI  - Annotations.

PMID- 29831570
TI  - Physic's Lenten Pastoral.

PMID- 29831569
TI  - Royal Sea-Bathing Infirmary at Margate.

PMID- 29831571
TI  - Around the Hospitals.

PMID- 29831572
TI  - Diet in Disease: XIII.-Diabetes.

PMID- 29831573
TI  - Annotations.

PMID- 29831574
TI  - Children's Cots.

PMID- 29831576
TI  - Rates versus Subscriptions.

PMID- 29831575
TI  - The Treatment of Fractured Patella.

PMID- 29831577
TI  - Vivisection: An Appeal to Reason.

PMID- 29831578
TI  - On Amputation.

PMID- 29831580
TI  - The Royal Frederick's Hospital, Copenhagen.

PMID- 29831579
TI  - Notes and News.

PMID- 29831581
TI  - Everybody's Page.

PMID- 29831582
TI  - The Attitude of Great Writers Towards Disease: XIV. Sir Thomas Browne.

PMID- 29831583
TI  - The Hospital Nursing Supplement.

PMID- 29831584
TI  - Medical History from the Earliest Times: XXIX.-Arabic Medicine-(2) The Eastern
      Caliphate.

PMID- 29831585
TI  - Leeds General Infirmary.

PMID- 29831586
TI  - Assistants' Manners and Nurses' Fees.

PMID- 29831587
TI  - The Fruits of Vivisection.

PMID- 29831589
TI  - Varicose Veins.

PMID- 29831588
TI  - The Treatment of Flat Foot.

PMID- 29831591
TI  - Everybody's Page.

PMID- 29831590
TI  - The Radcliffe Infirmary, Oxford.

PMID- 29831592
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29831593
TI  - Construction Notes.

PMID- 29831595
TI  - Annotations.

PMID- 29831594
TI  - The Treatment of Bronchitis.

PMID- 29831597
TI  - Mr. Lawson Tait and Vivisection.

PMID- 29831596
TI  - Around the Hospitals.

PMID- 29831599
TI  - The Prevention of Consumption.

PMID- 29831598
TI  - The Hull Royal Infirmary.

PMID- 29831600
TI  - Contemporary Theory and Research.

PMID- 29831601
TI  - Treatment of Rickets: III.-Medicines.

PMID- 29831602
TI  - Treatment of Naevus.

PMID- 29831604
TI  - Notes and News.

PMID- 29831603
TI  - Diet in Disease: XIV.-Diabetes.

PMID- 29831605
TI  - Lockers.

PMID- 29831606
TI  - Medical History from the Earliest Times: XLV.-The Revival of Learning.

PMID- 29831607
TI  - The Hospital Nursing Supplement.

PMID- 29831608
TI  - Around the Hospitals.

PMID- 29831609
TI  - The Hospital Nursing Supplement.

PMID- 29831610
TI  - The Attitude of Great Writers Towards Disease: XV. The Sick in Utopia.

PMID- 29831611
TI  - Annotations.

PMID- 29831612
TI  - Children's Cots.

PMID- 29831613
TI  - The Schoolmaster Very Much Abroad.

PMID- 29831614
TI  - Notes and News.

PMID- 29831615
TI  - Treatment of Chronic Ulcers of the Leg.

PMID- 29831616
TI  - Sheffield General Infirmary.

PMID- 29831617
TI  - Everybody's Page.

PMID- 29831618
TI  - Medical History from the Earliest Times: XXXI.-Arabic Medicine. (4) The Western
      Caliphate.

PMID- 29831619
TI  - Aix-La-Chapelle and Its Waters.

PMID- 29831620
TI  - Mind, Matter, and Medicine.

PMID- 29831622
TI  - The Choice of an Antiseptic.

PMID- 29831621
TI  - New Medicine for the New Times.

PMID- 29831623
TI  - The Feeding of Infants and Children. I.-Health.

PMID- 29831624
TI  - The Vibrating Helmet.

PMID- 29831625
TI  - Glasgow and Its Medical Institutions.

PMID- 29831626
TI  - The Birthplace of Cholera.

PMID- 29831627
TI  - Personalities.

PMID- 29831628
TI  - Hospitals in New Zealand.

PMID- 29831629
TI  - Treatment of Fractures of the Leg.

PMID- 29831630
TI  - Annotations.

PMID- 29831631
TI  - Fleming Memorial Hospital, Newcastle-On-Tyne.

PMID- 29831633
TI  - Children's Cots.

PMID- 29831632
TI  - Diet in Disease: V.-Restoratives. Tea.

PMID- 29831635
TI  - Treatment of Enteric Fever.

PMID- 29831634
TI  - Notes and News.

PMID- 29831636
TI  - Vivisection: An Appeal to Reason.

PMID- 29831637
TI  - The Hospital Nursing Supplement.

PMID- 29831638
TI  - The Morality of Vivisection.

PMID- 29831639
TI  - The Treatment of Chronic Suppuration of the Middle Ear.

PMID- 29831640
TI  - A Danger to Be Averted.

PMID- 29831641
TI  - Medical History from the Earliest Times: XXX.-Arabic Medicine-(3) Haly Abbas and
      Avicenna.

PMID- 29831642
TI  - The Hospital Nursing Supplement.

PMID- 29831644
TI  - Hospital Dresser's Table.

PMID- 29831643
TI  - Construction Notes.

PMID- 29831645
TI  - Annotations.

PMID- 29831646
TI  - Treatment of Intussusception.

PMID- 29831648
TI  - Medical History from the Earliest Times: XLVII.-Paracelsus.

PMID- 29831647
TI  - The Treatment of Headaches.

PMID- 29831649
TI  - Hospitals of the World: II. The Progress of English Nursing.

PMID- 29831650
TI  - Outpost Hospitals in Large Towns.

PMID- 29831651
TI  - The Treatment of Chorea.

PMID- 29831652
TI  - Diet in Disease: XVI.-Diabetes.

PMID- 29831653
TI  - Contemporary Theory and Research.

PMID- 29831654
TI  - Notes and News.

PMID- 29831655
TI  - Pensions for Old Age: II. Essential Points.

PMID- 29831656
TI  - The Treatment of Acute Rheumatism and Its Complications.

PMID- 29831658
TI  - What Is the Pension Fund Doing?

PMID- 29831657
TI  - Around the Hospitals.

PMID- 29831660
TI  - New Drugs, Appliances, and Things Medical: A New Form of Soda-Water Machine.

PMID- 29831659
TI  - New Drugs, Appliances, and Things Medical: Christia Tissue.

PMID- 29831661
TI  - The Hospital Nursing Supplement.

PMID- 29831662
TI  - The Last New Thing in Hospitals.

PMID- 29831663
TI  - The Feeding of Infants and Children. II.-In Disease.

PMID- 29831664
TI  - Faithfulness and Kingship.

PMID- 29831666
TI  - Berrywood Asylum.

PMID- 29831665
TI  - The Treatment of Pleurisy.

PMID- 29831667
TI  - The Fruits of Vivisection: A Reply to Sir Andrew Clark, Bart.

PMID- 29831668
TI  - Sheffield General Infirmary.

PMID- 29831669
TI  - Diet in Disease: VI.-Restoratives: Coffee, Cocoa. Chocolate.

PMID- 29831670
TI  - Attendants in the Olden Times.

PMID- 29831671
TI  - Notes and News.

PMID- 29831672
TI  - Annotations.

PMID- 29831673
TI  - The Treatment of Granular Lids.

PMID- 29831675
TI  - Medical History from the Earliest Times: XXXII.-Arabic Medicine. (5) Hospitals
      and Institutions.

PMID- 29831674
TI  - Around the Hospitals.

PMID- 29831677
TI  - The Story of the Insane from Year to Year.

PMID- 29831676
TI  - The Health of India.

PMID- 29831679
TI  - Engenolacetic Acid.

PMID- 29831678
TI  - Cottage Hospital. Keswick.

PMID- 29831680
TI  - Spinal Caries in Sick Children, Diagnosis and Treatment.

PMID- 29831682
TI  - General Civil Hospital, Colombo, Ceylon.

PMID- 29831681
TI  - Diet in Disease: XII.-Diabetes.

PMID- 29831683
TI  - Everybody's Page.

PMID- 29831684
TI  - Sunderland Infirmary.

PMID- 29831685
TI  - Colour Blindness.

PMID- 29831686
TI  - The Treatment of Morbus Coxae.

PMID- 29831687
TI  - Bedfordshire Hospital Trained Nurses' Institute.

PMID- 29831688
TI  - Schoolgirls' Food and Work.

PMID- 29831689
TI  - Annotations.

PMID- 29831690
TI  - Notes and News.

PMID- 29831691
TI  - Around the Hospitals.

PMID- 29831692
TI  - New Drugs, Appliances, and Things Medical: Safety Lamps.

PMID- 29831694
TI  - Medical History from the Earliest Times: XLII.-The Mediaeval Physician.

PMID- 29831693
TI  - The Hospital Nursing Supplement.

PMID- 29831695
TI  - Another Hint to the Oxford Infirmary.

PMID- 29831696
TI  - Asylums in India: II. The Madras Presidency.

PMID- 29831697
TI  - Why Do We Shiver?

PMID- 29831698
TI  - Bedford and Its Medical Institutions.

PMID- 29831699
TI  - Paying Patients at Special Hospitals.

PMID- 29831701
TI  - Notes and News.

PMID- 29831700
TI  - Edinburgh Royal Infirmary.

PMID- 29831702
TI  - The Treatment of Acute Rheumatism and Its Complications.

PMID- 29831703
TI  - The Hospital Nursing Supplement.

PMID- 29831705
TI  - Everybody's Page.

PMID- 29831704
TI  - The Treatment of Typhoid Fever.

PMID- 29831706
TI  - The Attitude of Great Writers Towards Disease: XVIII. Milton.

PMID- 29831707
TI  - Mr. Graham-Bennett.

PMID- 29831708
TI  - Annotations.

PMID- 29831709
TI  - Victoria Hospital, Folkestone.

PMID- 29831710
TI  - The Treatment of Pleurisy.

PMID- 29831711
TI  - Poor London!

PMID- 29831712
TI  - Royal Eye Hospital. Southwark.

PMID- 29831713
TI  - Medical History from the Earliest Times: XXXV.-The Darkest Age.

PMID- 29831715
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29831714
TI  - Railway Servants' Vision.

PMID- 29831716
TI  - Diet in Disease: IX. Digestion.

PMID- 29831717
TI  - Faces in the Crowd.

PMID- 29831718
TI  - Autobiographical.

PMID- 29831719
TI  - The Hospital Nursing Supplement.

PMID- 29831720
TI  - The Royal Infirmary, Dundee.

PMID- 29831721
TI  - Cooking by Gas.

PMID- 29831722
TI  - Musical Amnesia.

PMID- 29831723
TI  - Annotations.

PMID- 29831724
TI  - 1892.

PMID- 29831726
TI  - The Treatment of Tubercular Disease of the Joints.

PMID- 29831725
TI  - Hospitals in India: The Bengal Presidency-(1) Calcutta Medical Institutions.

PMID- 29831727
TI  - Haemorrhoids.

PMID- 29831728
TI  - The Other Side.

PMID- 29831729
TI  - Notes and News.

PMID- 29831730
TI  - Bradford Infirmary.

PMID- 29831731
TI  - The Hospital Nursing Supplement.

PMID- 29831732
TI  - The Attitude of Great Writers Towards Disease: XIX. Charles Lamb.

PMID- 29831734
TI  - The Guinea.

PMID- 29831733
TI  - Medical History from the Earliest Times: XXXVI.-The School of Salerno.

PMID- 29831735
TI  - The Madness of the Millionaire.

PMID- 29831736
TI  - The Treatment of the Complications.

PMID- 29831737
TI  - The Treatment of Some of the Complications and Sequelae of Middle Ear
      Suppuration.

PMID- 29831738
TI  - The Treatment of Rickets.

PMID- 29831740
TI  - The Treatment by Drugs.

PMID- 29831739
TI  - The Treatment of Acute Chorea.

PMID- 29831742
TI  - Annotations.

PMID- 29831741
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29831743
TI  - Charles Hamilton Fasson.

PMID- 29831744
TI  - Bedsteads.

PMID- 29831745
TI  - Diet in Disease: X.-Digestion-Absorption-Excretion.

PMID- 29831746
TI  - Notes and News.

PMID- 29831747
TI  - Miss Ethel M. Warner and Mr. Lawson Tait.

PMID- 29831748
TI  - The Attitude of Great Writers Towards Disease: XVII. Charles Kingsley.

PMID- 29831749
TI  - The Treatment of Spinal Disease.

PMID- 29831750
TI  - The Hospital Nursing Supplement.

PMID- 29831751
TI  - Bedsteads I.

PMID- 29831752
TI  - Everybody's Page.

PMID- 29831753
TI  - The Hospital for Curing the Poor in Their Own Homes of Loss of Movement from
      Paralysis, Rheumatism, and Deformity.

PMID- 29831754
TI  - Notes and News.

PMID- 29831755
TI  - Anti-Vivisectionists and Their Mistakes.

PMID- 29831757
TI  - Cremation or Burial?

PMID- 29831756
TI  - Annotations.

PMID- 29831758
TI  - Asylums of New Zealand.

PMID- 29831759
TI  - Bollingbroke House Pay Hospital.

PMID- 29831760
TI  - The Middlesex Hospital.

PMID- 29831761
TI  - Diet in Disease: VIII.-Digestion.

PMID- 29831762
TI  - Treatment of Inflammation of the Middle Ear.

PMID- 29831763
TI  - The Sunday Fund Meeting.

PMID- 29831764
TI  - Medical History from the Earliest Times: XXXIV.-The Darkest Age.

PMID- 29831765
TI  - The Treatment of Enteric Fever.

PMID- 29831766
TI  - The Hospital Nursing Supplement.

PMID- 29831768
TI  - Diet in Disease: XI.-Invalid Foods.

PMID- 29831767
TI  - Medical History from the Earliest Times: XXXVII.-The Ladies of Salerno.

PMID- 29831769
TI  - Annotations.

PMID- 29831770
TI  - Foul Language in Public Places.

PMID- 29831771
TI  - Everybody's Page.

PMID- 29831772
TI  - Notes and News.

PMID- 29831774
TI  - The Treatment of Some Forms of Heart Disease.

PMID- 29831773
TI  - The Social Horizon.

PMID- 29831775
TI  - New Drugs, Appliances, and Things Medical: An Antiseptic Hypodermic Syringe.

PMID- 29831777
TI  - The Treatment of Injuries to the Hand.

PMID- 29831776
TI  - Cheyne Hospital for Sick and Incurable Children, Cheyne Walk, Chelsea.

PMID- 29831778
TI  - The Treatment of Slighter Forms of In-Knee.

PMID- 29831779
TI  - Christmas Fare for the Children.

PMID- 29831781
TI  - To Will and to Do.

PMID- 29831780
TI  - This above All.

PMID- 29831783
TI  - The "W. H. Smith" Isolation Hospital, Henley-On-Thames.

PMID- 29831782
TI  - Diet in Disease: IV.-Stimulants: The Coca of Peru-Coca Wine.

PMID- 29831784
TI  - The Aberdeen Hospital for Sick Children.

PMID- 29831785
TI  - Morningside Asylum, Edinburgh.

PMID- 29831786
TI  - The Public School Boy's Body.

PMID- 29831787
TI  - Everybody's Page.

PMID- 29831788
TI  - Annotations.

PMID- 29831790
TI  - The Wisdom of the Moderns.

PMID- 29831789
TI  - Medical History from the Earliest Times: XXVIII.-Arabic Medicine-(1) The
      Translators.

PMID- 29831791
TI  - Treatment of Burns and Scalds.

PMID- 29831792
TI  - The Hospital Nursing Supplement.

PMID- 29831793
TI  - The Treatment of Typhoid Fever.

PMID- 29831794
TI  - The Central London Throat and Ear Hospital.

PMID- 29831796
TI  - The Treatment of Sprains of the Ankle.

PMID- 29831795
TI  - Notes and News.

PMID- 29831797
TI  - New Drugs, Appliances, and Things Medical: The "Carboline" Disinfectant.

PMID- 29831798
TI  - Construction Notes.

PMID- 29831800
TI  - The Worth of Inflammation.

PMID- 29831799
TI  - British Home for Incurables, Clapham Rise.

PMID- 29831802
TI  - Notes and News.

PMID- 29831801
TI  - The "Ordeal of Pauperism".

PMID- 29831803
TI  - Annotations.

PMID- 29831804
TI  - The Treatment of Post Nasal Adenoids.

PMID- 29831806
TI  - Moral Antiseptics.

PMID- 29831805
TI  - The Treatment of Colles's Fracture.

PMID- 29831807
TI  - The Treatment of Tubercular Disease of the Knee-Joint.

PMID- 29831809
TI  - The Attitude of Great Writers Towards Disease: XVI. Boccaccio.

PMID- 29831808
TI  - Medical History from the Earliest Times: XXXIII.-General Survey of Arabic
      Medicine.

PMID- 29831810
TI  - Diet in Disease: VI.-Water.-Salts.

PMID- 29831811
TI  - Opening of the New Medical Wing University College, Bristol.

PMID- 29831812
TI  - New Drugs. Appliances. And Things Medical.

PMID- 29831813
TI  - The Hospital Nursing Supplement.

PMID- 29831814
TI  - Notes and News.

PMID- 29831816
TI  - Where Are the Donors?

PMID- 29831815
TI  - Diet in Disease: III.-Stimulants: Alcohol.

PMID- 29831817
TI  - The Attitude of Great Writers Towards Disease: XIII. Elizabeth Barrett Browning.

PMID- 29831818
TI  - The Treatment of Corneal Ulcers.

PMID- 29831819
TI  - Medical History from the Earliest Times: XXVII-Byzantine Medicine.

PMID- 29831820
TI  - The Bitter Cry of Motherhood.

PMID- 29831821
TI  - Turning over New Leaves.

PMID- 29831822
TI  - The Treatment of Fractures of the Shaft of the Femur.

PMID- 29831823
TI  - Around the Hospitals.

PMID- 29831824
TI  - Special Hospitals: Ophthalmic and Miscellaneous: Cost of Management.

PMID- 29831825
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29831826
TI  - Devon and Exeter Hospital.

PMID- 29831827
TI  - The London Homoeopathic Hospital.

PMID- 29831828
TI  - The Treatment of Diphtheria.

PMID- 29831829
TI  - The Hospital Nursing Supplement.

PMID- 29831830
TI  - Annotations.

PMID- 29831831
TI  - The Ethics of Controversy.

PMID- 29831832
TI  - The Under-Five Citizen.

PMID- 29831833
TI  - President of King Edward's Hospital Fund.

PMID- 29831834
TI  - The Outbreak of Rabies: Are More Widespread Measures Necessary?

PMID- 29831835
TI  - The War and German Child-Life.

PMID- 29831836
TI  - Round the Hospitals.

PMID- 29831837
TI  - The Labour Party and a State Medical Service.

PMID- 29831838
TI  - The Therapeutic Value of a Becoming Costume.

PMID- 29831839
TI  - The Heating of Operating-Theatres.

PMID- 29831840
TI  - Hospital Annual Meetings.

PMID- 29831842
TI  - Critics of Present Conditions: Dawn of a Brighter Era: College Plans.

PMID- 29831841
TI  - A Final Duty on Demobilisation.

PMID- 29831844
TI  - Legal Notes for Institutional Workers.

PMID- 29831843
TI  - Its Frequency and a Remedy.

PMID- 29831846
TI  - Hospital and Institutional News.

PMID- 29831845
TI  - A Modern Idea of Gout.

PMID- 29831847
TI  - Hospitals in Native Regiments.

PMID- 29831848
TI  - Inclusive Fees for Private Patients.

PMID- 29831849
TI  - A Grave Scandal.

PMID- 29831850
TI  - Parliament and the Professions.

PMID- 29831852
TI  - Round the Hospitals.

PMID- 29831851
TI  - The Pneumonia Mortality: With Special Reference to the Influenza Complication.

PMID- 29831853
TI  - The Mechanical Genius and the Pen.

PMID- 29831854
TI  - The River past and God Forgotten.

PMID- 29831855
TI  - Australian Notes.

PMID- 29831856
TI  - Wound Shock: Lessons Derived from the War.

PMID- 29831858
TI  - Scheme of Development.

PMID- 29831857
TI  - Hospital and Institutional News.

PMID- 29831859
TI  - A Eugenic Problem.

PMID- 29831860
TI  - Rooks in Brighton.

PMID- 29831862
TI  - Betrayal Not Compromise.

PMID- 29831861
TI  - Health and the House.

PMID- 29831864
TI  - Subsidies for Consumptives.

PMID- 29831863
TI  - The Awakening of the Hospitals.

PMID- 29831865
TI  - The Treatment of Suppuration: With a Note on Maggots.

PMID- 29831867
TI  - Discussion in Standing Committee-Second Reading.

PMID- 29831866
TI  - The Army Chaplain.

PMID- 29831869
TI  - Hospital Annual Meetings.

PMID- 29831868
TI  - The Danger Lurking in the Bill.

PMID- 29831871
TI  - The Special Meeting of the B.M.A.

PMID- 29831870
TI  - The Dysenteries: A Review of Recent Experience.

PMID- 29831873
TI  - New Building Decided on.

PMID- 29831872
TI  - The Position of the Factory Nurse.

PMID- 29831874
TI  - Parliament and the Professions.

PMID- 29831875
TI  - Hospital and Institutional News.

PMID- 29831877
TI  - Wall Surfaces.

PMID- 29831876
TI  - High Sea Wanderings.

PMID- 29831879
TI  - The Need for Play.

PMID- 29831878
TI  - The Red Cross and the Nurse.

PMID- 29831881
TI  - Dangers of Middle Class Restaurants, Coffee Stalls and Some Public Houses.

PMID- 29831880
TI  - Round the Hospitals.

PMID- 29831882
TI  - Anaesthesia: The Promise of Future Refinement.

PMID- 29831883
TI  - The Real Test of the Nursing Spirit.

PMID- 29831884
TI  - District Nursing.

PMID- 29831885
TI  - The House of Lords Proves Its Value.

PMID- 29831887
TI  - Round the Hospitals.

PMID- 29831886
TI  - The Appearance of Plague.

PMID- 29831888
TI  - The College Bill in the House of Lords.

PMID- 29831889
TI  - No Gentlemen Need Apply.

PMID- 29831890
TI  - Margarine.

PMID- 29831891
TI  - V.A.D.'s Casualty Clearing Stations.

PMID- 29831893
TI  - Hospital and Institutional News.

PMID- 29831892
TI  - Landlords and Slums.

PMID- 29831894
TI  - The Ministry of Health and the Medical Profession.

PMID- 29831895
TI  - Edith Cavell's Home-Coming: With Many Illustrations.

PMID- 29831896
TI  - The Causes of Industrial Accidents.

PMID- 29831897
TI  - A Year's Work at Guy's Hospital.

PMID- 29831898
TI  - Re Working Hours of Private Nurses.

PMID- 29831899
TI  - Presentation at the Royal Society of Medicine.

PMID- 29831900
TI  - St. Dunstan's Methods for Civilian Institutions.

PMID- 29831901
TI  - Hospital Airships.

PMID- 29831902
TI  - Reform in Welfare Teaching.

PMID- 29831903
TI  - Well-Paid Matrons.

PMID- 29831904
TI  - Improvement in Drainage Systems.

PMID- 29831905
TI  - Parliament and the Profession.

PMID- 29831907
TI  - Civil Treatment of Accident Cases.

PMID- 29831906
TI  - Round the Hospitals.

PMID- 29831908
TI  - Prohibition or Freedom.

PMID- 29831909
TI  - The Marriage of Syphilitics.

PMID- 29831910
TI  - Gymkhana at Cardiff.

PMID- 29831911
TI  - Ierne Finds a Task for Every Member of the College.

PMID- 29831912
TI  - A Notable Anniversary.

PMID- 29831913
TI  - The Duties of a Sister-Tutor: The Strain of Constant Teaching.

PMID- 29831915
TI  - Hospital and Institutional News.

PMID- 29831914
TI  - The Question of Alcohol.

PMID- 29831916
TI  - Training-Schools and Business Habits.

PMID- 29831917
TI  - Hospital and Institutional News.

PMID- 29831918
TI  - The Standing Committee.

PMID- 29831920
TI  - Poor-Law Buildings and State Hospitals.

PMID- 29831919
TI  - The College Salaries Committee.

PMID- 29831922
TI  - Cerebro-Spinal Fever: A Triumph for Medical Investigation.

PMID- 29831921
TI  - Nursing Staff Salaries: Increase from the Top.

PMID- 29831924
TI  - The Action of King Edward's Hospital Fund for London.

PMID- 29831923
TI  - State Registration: A Jeremiad.

PMID- 29831926
TI  - Parliament and the Professions.

PMID- 29831925
TI  - Amendments to Be Moved by Colonel Raw on Behalf of the College of Nursing,
      Limited.

PMID- 29831928
TI  - Mental Nursing.

PMID- 29831927
TI  - Scheme for the Counties: The Needs of London.

PMID- 29831929
TI  - Committee Proceedings on the Bill.

PMID- 29831930
TI  - The Future of Vaccine Therapy.

PMID- 29831932
TI  - Water Supply on Active Service: Purification and Distribution Problems.

PMID- 29831931
TI  - Round the Hospitals.

PMID- 29831934
TI  - The Proposal to Erect the New Hospital on Clapham Common.

PMID- 29831933
TI  - Hospital Annual Meetings.

PMID- 29831935
TI  - The Two Registration Bills: A Matron's View.

PMID- 29831937
TI  - Round the Hospitals.

PMID- 29831936
TI  - From Sir Henry Burdett, to the Editor, "The Times".

PMID- 29831938
TI  - State Controlled and Voluntary Hospitals.

PMID- 29831939
TI  - Immunisation against Measles.

PMID- 29831941
TI  - Report of the Work of the past Quarter.

PMID- 29831940
TI  - From Mr. Herbert J. Paterson, to the Editor, "The Times."

PMID- 29831942
TI  - Stockport Infirmary.

PMID- 29831943
TI  - Hospital and Institutional News.

PMID- 29831944
TI  - The Carrel-Dakin and Allied Methods.

PMID- 29831945
TI  - The Working Hours of Private Nurses.

PMID- 29831946
TI  - The House of Lords and Nurse Registration.

PMID- 29831947
TI  - Toxidermias.

PMID- 29831948
TI  - Summer Time.

PMID- 29831949
TI  - A Substitute for Finsen Light.

PMID- 29831950
TI  - Report of the Salaries Committee of the College of Nursing.

PMID- 29831951
TI  - The Present Fate of the British Nurse?

PMID- 29831952
TI  - The Clearing of the Slums.

PMID- 29831953
TI  - A Supplementary Register for Fever Nursing.

PMID- 29831954
TI  - New Era Dawning under State Auspices: Nurses' Pensions: The Poor-Law Nurse.

PMID- 29831955
TI  - Conference at Central Hall, Westminster.

PMID- 29831956
TI  - The Power of Personal Service.

PMID- 29831958
TI  - Nurses and the League of Nations.

PMID- 29831957
TI  - An Historic Annual Meeting.

PMID- 29831960
TI  - Minor Thyroid Insufficiency: A Condition Met with Daily.

PMID- 29831959
TI  - Metropolitan Tuberculosis Difficulties.

PMID- 29831961
TI  - The Prevention of Cholera.

PMID- 29831962
TI  - Gum-Saline in Wound-Shock and Similar States.

PMID- 29831963
TI  - Rays and the Cancer Problem: Their Value and Limitations.

PMID- 29831964
TI  - Hospital and Institutional News.

PMID- 29831965
TI  - Round the Hospitals.

PMID- 29831966
TI  - The Health of the Collier: His Comparative Immunity from Phthisis.

PMID- 29831967
TI  - Impressions of a Visitor from the Provinces.

PMID- 29831968
TI  - Further Meditations on Gout.

PMID- 29831969
TI  - The Dangers of Big Panels.

PMID- 29831970
TI  - Poplar's Measures of Disinfection.

PMID- 29831972
TI  - Round the Hospitals.

PMID- 29831971
TI  - Hospital and Institutional News.

PMID- 29831974
TI  - Specially Trained Matrons in Demand.

PMID- 29831973
TI  - Convert Probation into Pupilage: A Golden Opportunity.

PMID- 29831976
TI  - Tuberculous Soldiers on the Land.

PMID- 29831975
TI  - The Patient's Posture in Bed.

PMID- 29831978
TI  - Cytology of the Blood.

PMID- 29831977
TI  - Formalin Treatment of Bed Sores.

PMID- 29831979
TI  - Hospital Reconstruction and Rebuilding: Cost per Bed for Building Alone.

PMID- 29831980
TI  - Charges of Medical Breakdown: The Official Reply.

PMID- 29831981
TI  - Special Building Materials.

PMID- 29831983
TI  - The Afghan War Scandals.

PMID- 29831982
TI  - The Action of Poison Gases.

PMID- 29831985
TI  - What Happens to Patients' Leavings?

PMID- 29831984
TI  - The Association of Hospital Matrons.

PMID- 29831987
TI  - Will Influenza Return?

PMID- 29831986
TI  - Practitioners, and the Marriage of Syphilitics.

PMID- 29831989
TI  - Round the Hospitals.

PMID- 29831988
TI  - Gun-Shot Fractures of the Femur.

PMID- 29831991
TI  - Tuberculosis Notes.

PMID- 29831990
TI  - The Royal British Nurses' Association.

PMID- 29831992
TI  - Newman's Fortreviver.

PMID- 29831993
TI  - Hospital and Institutional News.

PMID- 29831995
TI  - Overseas Nursing Association.

PMID- 29831994
TI  - Who Can the Lady Be?

PMID- 29831997
TI  - An Attractive Field for Research.

PMID- 29831996
TI  - Miller General Hospital.

PMID- 29831999
TI  - The Future of the Voluntary System.

PMID- 29831998
TI  - The Central Committee's Bill.

PMID- 29832000
TI  - Nurses and University Training.

PMID- 29832001
TI  - Great Possibilities in Prospect for the Nursing Profession.

PMID- 29832003
TI  - Hospital Gazettes for July.

PMID- 29832002
TI  - Madness and Marriage.

PMID- 29832005
TI  - Compulsory Segregation of Consumptives: Powers of Health Authorities.

PMID- 29832004
TI  - The Escape.

PMID- 29832006
TI  - Round the Hospitals.

PMID- 29832007
TI  - A Demonstration of Artificial Limbs.

PMID- 29832009
TI  - Hospital and Institutional News.

PMID- 29832008
TI  - Parliament and the Professions.

PMID- 29832011
TI  - The Preserving of Food: A Sketch of Some Objects in Research.

PMID- 29832010
TI  - The River's Tale.

PMID- 29832012
TI  - The Great Water Pageant: Tens of Thousands of People Present.

PMID- 29832013
TI  - A Business Girl's Views on the Slum Troubles.

PMID- 29832014
TI  - The Physical Side of the Probationer's Training.

PMID- 29832015
TI  - Some Points in Artificial Immunity.

PMID- 29832016
TI  - The Art of Diagnosis.

PMID- 29832017
TI  - Hospital Annual Meetings.

PMID- 29832018
TI  - The Choice of Names.

PMID- 29832019
TI  - Hospital and Institutional News.

PMID- 29832020
TI  - State Registration at Hand.

PMID- 29832021
TI  - Round the Hospitals.

PMID- 29832022
TI  - Barrasford Sanatorium's Finances.

PMID- 29832024
TI  - Rickets as a Dietetic Disease: An Outline of Recent Research.

PMID- 29832023
TI  - Parliament and the Professions.

PMID- 29832026
TI  - The College of Nursing and the State Recognition of Nurses.

PMID- 29832025
TI  - The Apotheosis of Kipps.

PMID- 29832028
TI  - A Remarkable Meeting.

PMID- 29832027
TI  - The Nursing Profession: Reconstruction v. Destruction.

PMID- 29832029
TI  - Second Reading Passed on Friday, March 28: The Debate.

PMID- 29832030
TI  - A Deliberate Suppression of the Facts.

PMID- 29832032
TI  - A Chapter on Business Method.

PMID- 29832031
TI  - Is This the End of an Old Difficulty?

PMID- 29832033
TI  - Our Defences against Smallpox.

PMID- 29832034
TI  - The Pocket-Handkerchief-A Seed-Sack of Death.

PMID- 29832035
TI  - Fees for Notification of Infectious Diseases.

PMID- 29832036
TI  - New Scale of Salaries at the London Hospital: Increase of L7,259 a Year.

PMID- 29832037
TI  - War Gratuities for Regular Officers.

PMID- 29832038
TI  - The Medical Research Committee: Fourth Annual Report.

PMID- 29832039
TI  - The Victimisation of V.A.D.s.

PMID- 29832040
TI  - Malaria in England.

PMID- 29832041
TI  - Erratum.
AB  - [This corrects the article on p. 566 in vol. 66.].

PMID- 29832042
TI  - Queen Charlotte's Hospital and Its Nursing Staff.

PMID- 29832043
TI  - Celluloid Splinting from Plaster Casts.

PMID- 29832044
TI  - Some Possible Clinical Units.

PMID- 29832045
TI  - Round the Hospitals.

PMID- 29832046
TI  - Nuns as Nurses: Trained Nurses Superseded?

PMID- 29832047
TI  - Twenty-One Years' Financial Progress.

PMID- 29832048
TI  - A Million for the Hospitals.

PMID- 29832049
TI  - A Small Independent Inquiry Commission Called for.

PMID- 29832050
TI  - A General's Criticism.

PMID- 29832051
TI  - Hospital and Institutional News.

PMID- 29832053
TI  - Pensions for All Mothers.

PMID- 29832052
TI  - Vincent's Angina: A Note of Recent Observations.

PMID- 29832055
TI  - How to Pay for Memorial Schemes: A Criticism and a Suggestion.

PMID- 29832054
TI  - The Open Coal-Fire.

PMID- 29832057
TI  - The Reorganisation of the Teaching of Medicine and Surgery.

PMID- 29832056
TI  - A Nurses' Club for Dublin.

PMID- 29832058
TI  - The Art of Attracting Probationers.

PMID- 29832060
TI  - The Voluntary Hospital Essential to Public Safety: Its Position of Financial
      Strength.

PMID- 29832059
TI  - The Secretary's Statements.

PMID- 29832062
TI  - After-War Reorganisation.

PMID- 29832061
TI  - Charles Mercier's Life Reflected in His Work.

PMID- 29832063
TI  - What of the Man?

PMID- 29832064
TI  - Report of the County Medical Officer of Health.

PMID- 29832065
TI  - The Filter-Passing Virus.

PMID- 29832066
TI  - Round the Hospitals.

PMID- 29832067
TI  - A Suggestion within Their Means.

PMID- 29832068
TI  - Tenement Houses: Some Drastic Changes Called for.

PMID- 29832070
TI  - Ca'-ing Canny Throughout the Nation?

PMID- 29832069
TI  - The Meaning of an Eight-Hour Day.

PMID- 29832071
TI  - Leicester Royal Infirmary.

PMID- 29832072
TI  - Hospital and Institutional News.

PMID- 29832074
TI  - Apothecaries' Assistants and Pharmacists.

PMID- 29832073
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29832076
TI  - Parliament and the Professions.

PMID- 29832075
TI  - Should the Garden Cities Be Extended?

PMID- 29832077
TI  - Women in Industry: A Review of Cause and Effect.

PMID- 29832078
TI  - Plague and the I.M.S.

PMID- 29832079
TI  - The Policy of Waiting.

PMID- 29832080
TI  - Cases Which May Benefit from Surgical Measures.

PMID- 29832081
TI  - Average Occupied Beds at St. George's Hospital.

PMID- 29832082
TI  - The Demobilisation of Temporary Officers in the R.A.M.C.

PMID- 29832084
TI  - Plastic and Reconstructive Surgery.

PMID- 29832083
TI  - Road to Efficient Health Maintenance Via the Hospitals.

PMID- 29832085
TI  - Hospital and Institutional News.

PMID- 29832086
TI  - A Convert to the Voluntary System.

PMID- 29832087
TI  - A Warning to the Government.

PMID- 29832088
TI  - The After-Effects of Lumbar Puncture.

PMID- 29832089
TI  - Its Coat of Arms and Badge. An Attractive Competition.

PMID- 29832091
TI  - The Exceptional Child in Ontario.

PMID- 29832090
TI  - State Registration and Mystery.

PMID- 29832092
TI  - Urgent Work for Press and Parliament.

PMID- 29832093
TI  - The Opportunity of the Smaller Hospitals.

PMID- 29832095
TI  - Hospital and Institutional News.

PMID- 29832094
TI  - Round the Hospitals.

PMID- 29832097
TI  - Effects of Louse Bites.

PMID- 29832096
TI  - The Church, Practitioners, and the Marriage of Syphilitics.

PMID- 29832099
TI  - The Society of Chemical Industry and Its Work.

PMID- 29832098
TI  - Round the Hospitals.

PMID- 29832100
TI  - Peace Celebrations at King Edward VII. Hospital, Cardiff.

PMID- 29832101
TI  - Foundation Meeting.

PMID- 29832103
TI  - Disease and Accident.

PMID- 29832102
TI  - Functional Diagnosis in Albuminuria.

PMID- 29832105
TI  - The Plague of Examinations.

PMID- 29832104
TI  - The Peace Celebration, July 19, 1919.

PMID- 29832107
TI  - The Voluntary Spirit v. State Control.

PMID- 29832106
TI  - Peace and Local Saturday Societies. The New Value of Money.

PMID- 29832109
TI  - Ante-Natal and Intra-Natal Care.

PMID- 29832108
TI  - The Conference at Leicester.

PMID- 29832110
TI  - The Endowment of Motherhood.

PMID- 29832111
TI  - Women in the Victory March, July 19, 1919.

PMID- 29832112
TI  - Parliament and the Profession.

PMID- 29832114
TI  - The Control of Hydrophobia: A More Simplified Procedure Necessary.

PMID- 29832113
TI  - Women's Holidays.

PMID- 29832115
TI  - Convalescence Amid Trees and Flowers.

PMID- 29832116
TI  - The Red Cross in Ireland: Something Wrong Somewhere.

PMID- 29832117
TI  - The New Health Regime: Consultative Councils.

PMID- 29832118
TI  - The Localisation of Missiles.

PMID- 29832120
TI  - The British Science Guild's Second Exhibition.

PMID- 29832119
TI  - Night Nurses' Meals.

PMID- 29832122
TI  - External Toxidermias.

PMID- 29832121
TI  - Round the Hospitals.

PMID- 29832124
TI  - Central Committee's Bill.

PMID- 29832123
TI  - Thanksgiving for Peace.

PMID- 29832125
TI  - The Hospital Treatment of Epidemic Diarrhoea.

PMID- 29832126
TI  - The Victory of King Edward's Hospital Fund for London.

PMID- 29832127
TI  - Parliament and the Profession.

PMID- 29832128
TI  - Tuberculosis and the War: Some Views on Future Developments.

PMID- 29832130
TI  - Should the Probationary System Be Revolutionised?

PMID- 29832129
TI  - Peace and the Profession.

PMID- 29832132
TI  - The Coming of Peace and Its Awakening Powers.

PMID- 29832131
TI  - Hospital and Institutional News.

PMID- 29832134
TI  - The Ministry of Health and National Baby Week.

PMID- 29832133
TI  - Physiognomy.

PMID- 29832136
TI  - The Necessity for Making Registration Attractive.

PMID- 29832135
TI  - The Marriage of Syphilitics.

PMID- 29832137
TI  - Bilharziasis and Its History: An Example of Recent Success.

PMID- 29832138
TI  - A Passive but Grave Menace.

PMID- 29832139
TI  - Hospital Affairs in Ireland: Radical Reforms Called for.

PMID- 29832140
TI  - The Eight-Hours' Day in Private Nursing.

PMID- 29832142
TI  - Queen Charlotte's Hospital and its Nursing Staff.

PMID- 29832141
TI  - Pearls in Food.

PMID- 29832143
TI  - Round the Hospitals.

PMID- 29832144
TI  - An Economical Substitute for Fresh Milk.

PMID- 29832146
TI  - Hospital and Institutional News.

PMID- 29832145
TI  - Structure and Management of Modern Dwellings.

PMID- 29832147
TI  - The White Operating-Theatre.

PMID- 29832148
TI  - Heatstroke and Allied Conditions: Types Seen in the Eastern Campaigns.

PMID- 29832149
TI  - A Bulwark of Security for the Patient.

PMID- 29832150
TI  - Staff Conditions in Hospitals.

PMID- 29832151
TI  - Ranyard Nurses.

PMID- 29832153
TI  - Free Midwives: The Practice in Big Towns.

PMID- 29832152
TI  - Tuberculosis at Home and Abroad.

PMID- 29832154
TI  - The Effort Syndrome: Soldier's Heart.

PMID- 29832155
TI  - An Insufficient Medical Service.

PMID- 29832157
TI  - The Details of Splint Application.

PMID- 29832156
TI  - Hospital and Institutional News.

PMID- 29832158
TI  - Headquarters' Failure in India.

PMID- 29832159
TI  - Royal Gwent Hospital: Grant of Arms.

PMID- 29832160
TI  - Hospitals' Reply to Lord Crawford.

PMID- 29832161
TI  - Tuberculosis in Private Practice: Some Points in Early Diagnosis and Prevention.

PMID- 29832162
TI  - The Future of Unqualified Nurses.

PMID- 29832163
TI  - Parliament and the Professions.

PMID- 29832164
TI  - Results; and Proposed Chair of Tuberculosis.

PMID- 29832166
TI  - Round the Hospitals.

PMID- 29832165
TI  - Income-Tax Liabilities and Claims.

PMID- 29832167
TI  - Neurasthenia and Its Cure: The Effect of Handicraft on Mind and Body.

PMID- 29832168
TI  - The Novice in General Practice.

PMID- 29832170
TI  - The Kata-Thermometer.

PMID- 29832169
TI  - Nurses the Exclusive Occupiers of a New Field.

PMID- 29832171
TI  - From Mr. Herbert J. Paterson, to the Editor of "The Times."

PMID- 29832172
TI  - The Mortality of Child-Bearing: Reasons for Continued High Figures.

PMID- 29832173
TI  - Hospital and Institutional News.

PMID- 29832175
TI  - Self-Determination for Nurses.

PMID- 29832174
TI  - The New Nurses' Prospects.

PMID- 29832176
TI  - The Need for Common Sense Extension.

PMID- 29832177
TI  - Royal Hospital and Home for Incurables, Putney.

PMID- 29832178
TI  - Nurses v. Trade Unions.

PMID- 29832179
TI  - Lessons Learnt and the Need to Apply Them.

PMID- 29832180
TI  - Report of the Salaries Committee of the College of Nursing.

PMID- 29832181
TI  - Round the Hospitals.

PMID- 29832182
TI  - Professional Secrecy.

PMID- 29832183
TI  - Helping the Architect.

PMID- 29832184
TI  - The Individual and the Homestead.

PMID- 29832185
TI  - Hospital Libraries: A Scheme for Centralisation.

PMID- 29832187
TI  - Parliament and the Professions.

PMID- 29832186
TI  - From Sir Henry Burdett, to the Editor of "The Times."

PMID- 29832188
TI  - The River Past, God Forgotten, and the Ferryman Punished.

PMID- 29832189
TI  - Parliament and the Profession.

PMID- 29832191
TI  - The Differential Diagnosis of Smallpox.

PMID- 29832190
TI  - Gum-Saline in Wound-Shock and Similar States.

PMID- 29832193
TI  - Teaching of Preventive Medicine.

PMID- 29832192
TI  - The Decline in Population.

PMID- 29832195
TI  - The New Union among Matrons.

PMID- 29832194
TI  - Representative Inaugural Meeting at St. Thomas's Hospital.

PMID- 29832197
TI  - At the Ocean Gates of Britain.

PMID- 29832196
TI  - The R.A.M.C. War Memorial.

PMID- 29832198
TI  - A General Introduction.

PMID- 29832199
TI  - Hospital and Institutional News.

PMID- 29832200
TI  - The Central Committee's Nurse Registration Bill.

PMID- 29832201
TI  - The Housing Bill: Objects and Finance.

PMID- 29832202
TI  - Sitting Tight While Others Fight.

PMID- 29832204
TI  - The British Farmers' Hospital.

PMID- 29832203
TI  - The Working Hours of the Private Nurse: A Problem to Be Solved.

PMID- 29832206
TI  - Round the Hospitals.

PMID- 29832205
TI  - One-Story versus Many-Story Methods.

PMID- 29832207
TI  - Hospital Annual Meetings.

PMID- 29832208
TI  - The Victory Parade and After: Something Worth Attention by Each Man and Woman.

PMID- 29832209
TI  - Round the Hospitals.

PMID- 29832210
TI  - How Immediate and Urgent Needs Are Met.

PMID- 29832211
TI  - Wound Shock and Surgical Shock.

PMID- 29832212
TI  - The New Spirit among Probationers.

PMID- 29832213
TI  - Hospital and Institutional News.

PMID- 29832214
TI  - As They Are Viewed by Their Fellow-Nurses.

PMID- 29832215
TI  - Work for the V.A.D.s.

PMID- 29832216
TI  - Blood Transfusion: An Outline of the Technique and Applications.

PMID- 29832218
TI  - The Super-Child: Progressive Ideas and a Nation's Simple Duty.

PMID- 29832217
TI  - Surgery of the Knee: Notes of a Recent Development.

PMID- 29832219
TI  - Some of the Examination Questions.

PMID- 29832220
TI  - Books and the War.

PMID- 29832221
TI  - Pensions Problems.

PMID- 29832222
TI  - The London Hospital "Gazette."

PMID- 29832223
TI  - The Case of the Neurasthenic.

PMID- 29832224
TI  - Compound Fractures.

PMID- 29832225
TI  - The Improvement of Food Supplies.

PMID- 29832226
TI  - Masked Men at Guy's Hospital.

PMID- 29832227
TI  - Are Many Hospitals to Be Closed?

PMID- 29832228
TI  - The Call to Members of the College.

PMID- 29832229
TI  - The Church, Practitioners, and the Marriage of Syphilitics.

PMID- 29832230
TI  - Nurses' Registration.

PMID- 29832231
TI  - The Church and the Marriage of Syphilitics.

PMID- 29832232
TI  - The College of Nursing.

PMID- 29832233
TI  - The Royal Army Medical Corps.

PMID- 29832234
TI  - Registration and the Ministry of Health.

PMID- 29832235
TI  - Islington War Memorial.

PMID- 29832236
TI  - Doctors' War Bonus Increased.

PMID- 29832237
TI  - Hospital and Institutional News.

PMID- 29832238
TI  - Demobilisation and the Y.M.C.A.

PMID- 29832240
TI  - Report of the Salaries Committee of the College of Nursing.

PMID- 29832239
TI  - Hospitals and Dental Service.

PMID- 29832241
TI  - Round the Hospitals.

PMID- 29832242
TI  - Modern Treatment of Burns.

PMID- 29832243
TI  - The Modern London Training-School for Nurses.

PMID- 29832244
TI  - The Primary Suture of Wounds.

PMID- 29832245
TI  - An Optimum Population.

PMID- 29832246
TI  - Hospital and Institutional News.

PMID- 29832247
TI  - The Relation of Voluntary Hospitals to the State.

PMID- 29832248
TI  - The Working Hours of the Private Nurse.

PMID- 29832249
TI  - The Editor's Letter-Box.

PMID- 29832250
TI  - Association of Hospital Matrons.

PMID- 29832251
TI  - Hospital Annual Meetings.

PMID- 29832252
TI  - The Vulgar Person.

PMID- 29832253
TI  - Hospitals in the Arctic.

PMID- 29832254
TI  - The Control of the Sale of Drink.

PMID- 29832255
TI  - Edith Cavell: At Erpingham Gate, Norwich Cathedral.

PMID- 29832256
TI  - Viscount Burnham and Maitre De Leval on Nurse Cavell: Her Last Words Recorded.

PMID- 29832257
TI  - The Smoking Habit.

PMID- 29832258
TI  - An Outline of the Allen Method.

PMID- 29832259
TI  - Round the Hospitals.

PMID- 29832261
TI  - Hospital and Institutional News.

PMID- 29832260
TI  - Norfolk and Norwich Hospital.

PMID- 29832262
TI  - The Uses of Costing.

PMID- 29832263
TI  - In War and in the Future.

PMID- 29832265
TI  - A Comparison with Civil Practice.

PMID- 29832264
TI  - Prospects and Opportunities Soon to Be Encountered.

PMID- 29832266
TI  - The Medical Schools of the United Kingdom.

PMID- 29832267
TI  - Oxford University Course.

PMID- 29832268
TI  - Dentistry as a Profession.

PMID- 29832269
TI  - Medical Schools in Scotland.

PMID- 29832270
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29832271
TI  - The Certainties and Uncertainties of the Medical Outlook.

PMID- 29832272
TI  - Medical Schools in Ireland.

PMID- 29832273
TI  - The Future Outlook.

PMID- 29832274
TI  - London University Course.

PMID- 29832275
TI  - Qualification and Registration.

PMID- 29832276
TI  - Navy, Army, Air and Colonial Services.

PMID- 29832277
TI  - Higher Diplomas.

PMID- 29832278
TI  - More Evils of German and Austrian Clinics.

PMID- 29832279
TI  - Ophthalmic Education in Egypt.

PMID- 29832280
TI  - The Public Health Services.

PMID- 29832281
TI  - Some Outstanding Points in Clinical Medicine.

PMID- 29832282
TI  - The English Conjoint Course.

PMID- 29832284
TI  - Medical Schools in the Provinces.

PMID- 29832283
TI  - The College of Nursing: Wanted Potential Energy!

PMID- 29832285
TI  - Cambridge University Course.

PMID- 29832286
TI  - New Orders Affecting Service Nurses.

PMID- 29832288
TI  - The Clifford Allbutt Presentation.

PMID- 29832287
TI  - Fourth Annual Meeting at Manchester.

PMID- 29832290
TI  - Hospitals and Their Special Needs.

PMID- 29832289
TI  - Vitamines: A Brief Summary with a Forecast.

PMID- 29832291
TI  - Medical Mission Work in Frontier Hospitals.

PMID- 29832292
TI  - The Importance of a Low Registration Fee.

PMID- 29832293
TI  - The Voluntary Hospitals' Budget.

PMID- 29832294
TI  - The Central Committee's Bill and Nurses in Practice.

PMID- 29832296
TI  - Hospital and Institutional News.

PMID- 29832295
TI  - Professional Secrecy-Dr. Hawthorne's View.

PMID- 29832298
TI  - Round the Hospitals.

PMID- 29832297
TI  - St. Paul's Cathedral, June 13, 1919.

PMID- 29832299
TI  - The Archbishop of Canterbury Speaks to the People.

PMID- 29832300
TI  - Annual and Other Meetings.

PMID- 29832301
TI  - Hospital Sunday, 1919.

PMID- 29832302
TI  - Ierne Speaks out and Strikes Home.

PMID- 29832303
TI  - Over 1,600,000 Sufferers Helped by Our Hospitals: A Single Year's Roll-Call of
      the Sick.

PMID- 29832304
TI  - 1918. A Year's Work in the Hospitals and Medical Charities of London.

PMID- 29832305
TI  - On Physiognomy.

PMID- 29832306
TI  - Reconstruction and the Sunday Fund.

PMID- 29832308
TI  - The Medico-Psychological Society.

PMID- 29832307
TI  - Hospital Life in Jerusalem.

PMID- 29832309
TI  - The Poor Man's Home.-II.

PMID- 29832310
TI  - The Art of Longevity.

PMID- 29832311
TI  - Progress in Surgery.

PMID- 29832312
TI  - Asylum Officials and Their Pensions.

PMID- 29832313
TI  - "The Hospital" Nursing Mirror.

PMID- 29832314
TI  - Notes and News.

PMID- 29832315
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832316
TI  - The Story of the Insane from Year to Year.

PMID- 29832317
TI  - Around the Hospitals.

PMID- 29832318
TI  - New Appliances and Things Medical.

PMID- 29832319
TI  - The Truth of Sensational Paragraphs.

PMID- 29832320
TI  - Notes of Hospital Clinics.

PMID- 29832321
TI  - Progress in Medicine.

PMID- 29832322
TI  - Annotations.

PMID- 29832323
TI  - Notes and News.

PMID- 29832324
TI  - The Chemists' Exhibition.

PMID- 29832325
TI  - Execution by Electricity.

PMID- 29832326
TI  - "The Hospital" Nursing Mirror.

PMID- 29832327
TI  - The Morals of Children.

PMID- 29832328
TI  - Progress in Medicine.

PMID- 29832329
TI  - Annotations.

PMID- 29832330
TI  - Around the Hospitals.

PMID- 29832331
TI  - Notes of Hospital Clinics.

PMID- 29832332
TI  - Progress in Surgery.

PMID- 29832333
TI  - The Poor Man's Home.-I.

PMID- 29832334
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832335
TI  - The Story of the Insane from Year to Year.

PMID- 29832336
TI  - Doctor or Not Doctor?

PMID- 29832337
TI  - Annotations.

PMID- 29832338
TI  - Sea-Sickness.

PMID- 29832340
TI  - New Appliances and Things Medical.

PMID- 29832339
TI  - Progress in Medicine.

PMID- 29832341
TI  - Notes and News.

PMID- 29832342
TI  - "The Hospital" Nursing Mirror.

PMID- 29832343
TI  - The Plague and Anti-Toxic Serum.

PMID- 29832344
TI  - The Abuse of the Forceps.

PMID- 29832345
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832346
TI  - The Poor Man's Home.-V: Health Laws in Many Lands.

PMID- 29832347
TI  - The Story of the Insane from Year to Year.

PMID- 29832348
TI  - Mutual Admiration Societies.

PMID- 29832350
TI  - Chemistry and Pathology.

PMID- 29832349
TI  - Sanitary Administration in America.

PMID- 29832351
TI  - Progress in Surgery.

PMID- 29832352
TI  - Royal Medical and Chirurgical Society.

PMID- 29832353
TI  - Serum Treatment and Its Limitations.

PMID- 29832354
TI  - Practical Departments.

PMID- 29832355
TI  - Hospital Meetings, &c.

PMID- 29832356
TI  - Sanitation for Scotland.

PMID- 29832357
TI  - Medical Education.

PMID- 29832358
TI  - Progress in Medicine.

PMID- 29832359
TI  - Annotations.

PMID- 29832360
TI  - The Oration of the Medical Society of London.

PMID- 29832362
TI  - Asylums Board Report on Antitoxic Serum.

PMID- 29832361
TI  - Notes and News.

PMID- 29832363
TI  - "The Hospital" Nursing Mirror.

PMID- 29832364
TI  - Progress in Surgery.

PMID- 29832365
TI  - Hereditary Neuroses in Children.-III.

PMID- 29832366
TI  - Periscope of Dermatology.

PMID- 29832367
TI  - The Treatment of Synovitis of the Knee-Joint.

PMID- 29832368
TI  - Nursing in Workhouses.

PMID- 29832369
TI  - "The Hospital" Nursing Mirror.

PMID- 29832371
TI  - The Medical Schools of the Metropolis.

PMID- 29832370
TI  - Guy's Hospital: A Case of Rupture of the Bladder.

PMID- 29832373
TI  - Annotations.

PMID- 29832372
TI  - The Poor Man's Home.-III.

PMID- 29832374
TI  - Cottage Hospital Administration.

PMID- 29832375
TI  - The Victoria Hospital, Blackpool.

PMID- 29832377
TI  - Notes and News.

PMID- 29832376
TI  - Medical Education in Scotland.

PMID- 29832379
TI  - The Qualified Dentist.

PMID- 29832378
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832381
TI  - The Expenditure at the Mary Wardell Convalescent Home.

PMID- 29832380
TI  - New Appliances and Things Medical.

PMID- 29832383
TI  - Progress in Medicine.

PMID- 29832382
TI  - Progress in Surgery.

PMID- 29832385
TI  - Medicine as a Profession.

PMID- 29832384
TI  - Medicine as a Study.

PMID- 29832386
TI  - Editor's Letter-Box.

PMID- 29832387
TI  - Education of the Judgment.

PMID- 29832388
TI  - Annotations.

PMID- 29832389
TI  - Notes and News.

PMID- 29832390
TI  - Hereditary Neuroses in Children.-II.

PMID- 29832391
TI  - The Charity Organisation Society and the Hospitals.

PMID- 29832392
TI  - The Blackwall Tunnel from a Medical Point of View.

PMID- 29832393
TI  - Periscope of Dermatology.

PMID- 29832394
TI  - Some Resources in the Diagnosis of Nervous Diseases.

PMID- 29832395
TI  - Hospital Meetings, &c.

PMID- 29832396
TI  - Progress in Surgery.

PMID- 29832397
TI  - The Workmen's Compensation Bill.

PMID- 29832398
TI  - The Housing of the Working Classes Act.

PMID- 29832399
TI  - The Prince of Wales' Hospital Stamps.

PMID- 29832400
TI  - "The Hospital" Nursing Mirror.

PMID- 29832401
TI  - Progress in Medicine.

PMID- 29832402
TI  - The Story of the Insane from Year to Year.

PMID- 29832403
TI  - Progress in Surgery.

PMID- 29832405
TI  - The Rating of Voluntary Hospitals.

PMID- 29832404
TI  - Notes and News.

PMID- 29832406
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832408
TI  - Practical Departments.

PMID- 29832407
TI  - The "Medical Press" and the Hospital Sunday Fund.

PMID- 29832410
TI  - Notes from the Congresses.

PMID- 29832409
TI  - The Poor Man's Home.-IV.

PMID- 29832412
TI  - "The Hospital" Nursing Mirror.

PMID- 29832411
TI  - Annotations.

PMID- 29832414
TI  - The Congresses.

PMID- 29832413
TI  - Holidays.

PMID- 29832415
TI  - Annotations.

PMID- 29832416
TI  - Around the Hospitals.

PMID- 29832418
TI  - Church and Sanitation.

PMID- 29832417
TI  - The Dietetic Treatment of Diabetes.

PMID- 29832420
TI  - Diphtheria and Sanitation.

PMID- 29832419
TI  - Progress in Surgery.

PMID- 29832421
TI  - The Poor Man's Home.-VI: Health Laws in Many Lands (continued).

PMID- 29832422
TI  - New Appliances and Things Medical.

PMID- 29832424
TI  - The Rating of Voluntary Hospitals.

PMID- 29832423
TI  - "The Hospital" Nursing Mirror.

PMID- 29832426
TI  - Hospitals, Charity, and Organisations.

PMID- 29832425
TI  - Yellow Fever.

PMID- 29832427
TI  - Progress in Medicine.

PMID- 29832428
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832429
TI  - Impressions of a Russian Hospital.

PMID- 29832430
TI  - Progress in State Medicine.

PMID- 29832431
TI  - Notes and News.

PMID- 29832432
TI  - The Radical Cure of Femoral Hernia.

PMID- 29832433
TI  - The Vacancy in the General Medical Council.

PMID- 29832434
TI  - The Story of the Insane from Year to Year.

PMID- 29832436
TI  - Skin Transplantation.

PMID- 29832435
TI  - "Official" or "Unofficial".

PMID- 29832438
TI  - Hospital Meetings, &c.

PMID- 29832437
TI  - Hospital Reform Association.

PMID- 29832439
TI  - The Yarrow Convalescent Home.

PMID- 29832440
TI  - Immunity to Bee Stings.

PMID- 29832441
TI  - Progress in Medicine.

PMID- 29832442
TI  - Intra-Muscular Injections of Mercury in the Treatment of Syphilis.

PMID- 29832443
TI  - The Plague in India.

PMID- 29832444
TI  - "The Hospital" Nursing Mirror.

PMID- 29832446
TI  - Blocking of the Larynx by a Caseous Gland.

PMID- 29832447
TI  - The Dangers of Uterine Myomata.

PMID- 29832449
TI  - Notes.

PMID- 29832448
TI  - Serous Pleuritic Effusion Treated by Incision.

PMID- 29832450
TI  - A Case of Pneumonia with Cerebral Complications.

PMID- 29832452
TI  - West African Fevers.

PMID- 29832451
TI  - Annotations.

PMID- 29832453
TI  - Progress in Surgery.

PMID- 29832454
TI  - The Manchester Royal Infirmary.

PMID- 29832456
TI  - Notes and News.

PMID- 29832455
TI  - The Poor Man's Home.-XXVII: Building Societies.

PMID- 29832457
TI  - The "Treatment" of Measles by Nurses.

PMID- 29832458
TI  - Annotations.

PMID- 29832460
TI  - Progress in Medicine.

PMID- 29832459
TI  - "Official" or "Unofficial".

PMID- 29832461
TI  - Lady Doctors in Germany.

PMID- 29832462
TI  - The Darenth Scandal.

PMID- 29832464
TI  - The Plague.

PMID- 29832463
TI  - Editor's Letter-Box.

PMID- 29832465
TI  - Hospital Meetings, &c.

PMID- 29832466
TI  - "The Hospital" Nursing Mirror.

PMID- 29832467
TI  - The Poor Man's Home.-XXIV: Model Lodging-Houses (continued).

PMID- 29832468
TI  - Progress in Surgery.

PMID- 29832469
TI  - The Maidstone Epidemic.

PMID- 29832470
TI  - Notes and News.

PMID- 29832471
TI  - Deaths from Anaesthetics.

PMID- 29832472
TI  - Progress in Ophthalmology.

PMID- 29832473
TI  - Prince of Wales's Hospital Fund for London.

PMID- 29832474
TI  - New Appliances and Things Medical.

PMID- 29832476
TI  - Extra-Uterine Gestation.

PMID- 29832475
TI  - The Diagnosis of Syphilitic Skin Affections.

PMID- 29832478
TI  - The Poor Man's Home.-XXVI: Ticketed Rooms and Other Lodgings.

PMID- 29832477
TI  - Rectal Surgery.

PMID- 29832479
TI  - Progress in Medicine.

PMID- 29832480
TI  - A Case of Pneumonia with Cerebral Complications.

PMID- 29832483
TI  - The British Laryngological, Rhinological, and Otological Society.

PMID- 29832481
TI  - Libel Actions by Medical Practitioners.

PMID- 29832484
TI  - Progress in Surgery.

PMID- 29832485
TI  - Notes and News.

PMID- 29832487
TI  - Hospital Meetings, &c.

PMID- 29832486
TI  - Asylum Worthies.

PMID- 29832489
TI  - The Regulation or the Abolition of Midwives.

PMID- 29832488
TI  - "Complete" and "Incomplete" Operations.

PMID- 29832490
TI  - Annotations.

PMID- 29832491
TI  - The "Star" on Vivisection.

PMID- 29832492
TI  - "The Hospital" Nursing Mirror.

PMID- 29832493
TI  - Economics of Philanthropy.

PMID- 29832495
TI  - New Appliances and Things Medical.

PMID- 29832494
TI  - Operations for Breast Cancer.

PMID- 29832496
TI  - Notes and News.

PMID- 29832497
TI  - Progress in Medicine.

PMID- 29832499
TI  - Hospital Meetings, &c.

PMID- 29832498
TI  - The Colony for Epileptics.

PMID- 29832501
TI  - Disinfection.

PMID- 29832500
TI  - New Appliances and Things Medical.

PMID- 29832502
TI  - The Prince of Wales's Hospital Fund Stamps.

PMID- 29832503
TI  - "The Hospital" Nursing Mirror.

PMID- 29832505
TI  - The Hospitals and Vivisection.

PMID- 29832504
TI  - Royal Medical and Chirurgical Society.

PMID- 29832507
TI  - Hereditary Neuroses in Children.-I.

PMID- 29832506
TI  - Annotations.

PMID- 29832508
TI  - The Neuroses of the Menopause.

PMID- 29832509
TI  - Progress in Surgery.

PMID- 29832510
TI  - Periscope of Dermatology.

PMID- 29832511
TI  - The Question of Operation in Chronic Non-Suppurative Ear Disease.

PMID- 29832512
TI  - Death by Fire.

PMID- 29832513
TI  - Co-Operation and Charity.

PMID- 29832515
TI  - Lunatics in Unlicensed Houses.

PMID- 29832514
TI  - Nursing in Workhouses.

PMID- 29832516
TI  - "The Hospital" Nursing Mirror.

PMID- 29832517
TI  - Annotations.

PMID- 29832518
TI  - Notes and News.

PMID- 29832519
TI  - The Poor Man's Lawyer.

PMID- 29832520
TI  - German Statistics Regarding Anaesthetics.

PMID- 29832521
TI  - Hospital Construction.

PMID- 29832522
TI  - A Note on the Bacteriological Conditions Present in Ulcers Treated by Oxygen Gas.

PMID- 29832523
TI  - Epidemiological Society.

PMID- 29832524
TI  - Progress in Medicine.

PMID- 29832526
TI  - The Fumigation of an Ambassador.

PMID- 29832525
TI  - Hospital Meetings, &c.

PMID- 29832528
TI  - Workmen's Compensation: Its Medical Aspect.

PMID- 29832527
TI  - Harveian Society.

PMID- 29832530
TI  - Progress in Surgery.

PMID- 29832529
TI  - The Story of the Insane from Year to Year.

PMID- 29832532
TI  - Annotations.

PMID- 29832531
TI  - Phimosis.

PMID- 29832533
TI  - Pitfalls in Bacteriological Diagnosis.

PMID- 29832534
TI  - The Workhouse Swill-Tub.

PMID- 29832536
TI  - Progress in Gynaecology.

PMID- 29832535
TI  - Notes and News.

PMID- 29832538
TI  - "The Hospital" Nursing Mirror.

PMID- 29832537
TI  - The Furnishing and Appliances of a Cottage Hospital.

PMID- 29832540
TI  - New Appliances and Things Medical.

PMID- 29832539
TI  - The Muzzling Order and Its Effects.

PMID- 29832542
TI  - Progress in Medicine.

PMID- 29832541
TI  - Vibrator Massage of the Uterus.

PMID- 29832544
TI  - The Decadence of the Negro.

PMID- 29832543
TI  - The Story of the Insane from Year to Year.

PMID- 29832545
TI  - Child Life under Queen Victoria: XI. The Society for the Prevention of Cruelty to
      Children.

PMID- 29832546
TI  - Progress in Surgery.

PMID- 29832547
TI  - Treatment before Diagnosis.

PMID- 29832548
TI  - Malaria and Its Mode of Access.

PMID- 29832550
TI  - Annotations.

PMID- 29832549
TI  - The Means by Which the Temperature of the Body Is Maintained in Health and
      Disease: Lecture IV.

PMID- 29832552
TI  - New Appliances and Things Medical.

PMID- 29832551
TI  - The Adelaide Hospital and the British Medical Association.

PMID- 29832554
TI  - Around the Hospitals.

PMID- 29832553
TI  - Progress in Surgery.

PMID- 29832555
TI  - Notes and News.

PMID- 29832556
TI  - Technical Education in London.

PMID- 29832558
TI  - Oxygen Home.

PMID- 29832557
TI  - Hospital Construction.

PMID- 29832559
TI  - The Story of the Insane from Year to Year.

PMID- 29832560
TI  - Sanitation and Superstition.

PMID- 29832561
TI  - Modern Views as to the Surgical Treatment of Fibro-Myomata of the Uterus.

PMID- 29832563
TI  - Spectacles and Asthenopia.

PMID- 29832562
TI  - Street Collections.

PMID- 29832565
TI  - "The Hospital" Nursing Mirror.

PMID- 29832564
TI  - Some Cape Town Institutions.

PMID- 29832567
TI  - Electricity and Dust.

PMID- 29832566
TI  - Progress in Medicine.

PMID- 29832568
TI  - Child Life under Queen Victoria: XII. What Remains to Be Done.

PMID- 29832569
TI  - "The Hospital" Nursing Mirror.

PMID- 29832571
TI  - Population Statistics for 1895.

PMID- 29832570
TI  - Progress in Gynaecology.

PMID- 29832573
TI  - Annotations.

PMID- 29832572
TI  - New Appliances and Things Medical.

PMID- 29832575
TI  - The Causes and Treatment of Chloroform Syncope.

PMID- 29832574
TI  - The Pay System in Hospitals.

PMID- 29832577
TI  - Royal Medical and Chirurgical Society.

PMID- 29832576
TI  - Notes and News.

PMID- 29832578
TI  - Manual Training in Surgery.

PMID- 29832579
TI  - Progress in Medicine.

PMID- 29832581
TI  - The Story of the Insane from Year to Year.

PMID- 29832580
TI  - Hospital Construction.

PMID- 29832583
TI  - Construction Notes.

PMID- 29832582
TI  - A Healthy Little Town!

PMID- 29832585
TI  - Deaths under Anaesthetics.

PMID- 29832584
TI  - The Microbes of Seborrhoea and of Acne.

PMID- 29832587
TI  - The Distribution of the Hospital Sunday Fund.

PMID- 29832586
TI  - Solitary Confinement and Insanity.

PMID- 29832589
TI  - The Story of the Insane from Year to Year.

PMID- 29832588
TI  - Hospital Meetings, &c.

PMID- 29832590
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29832591
TI  - Typhus Fever.

PMID- 29832593
TI  - "The Hospital" Nursing Mirror.

PMID- 29832592
TI  - Notes and News.

PMID- 29832594
TI  - Progress in Medicine.

PMID- 29832595
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832596
TI  - Notes of Hospital Clinics.

PMID- 29832597
TI  - Annotations.

PMID- 29832599
TI  - Metropolitan Asylums Board.

PMID- 29832598
TI  - New Appliances and Things Medical.

PMID- 29832600
TI  - The Causes of Sudden Death.

PMID- 29832601
TI  - The Means by Which the Temperature of the Body Is Maintained in Health and
      Disease: Lecture III.

PMID- 29832602
TI  - Annotations.

PMID- 29832603
TI  - "The Hospital" Nursing Mirror.

PMID- 29832604
TI  - Progress in Surgery.

PMID- 29832605
TI  - English Doctors Abroad.

PMID- 29832607
TI  - Hospital Construction.

PMID- 29832606
TI  - Notes and News.

PMID- 29832608
TI  - Practical Departments.

PMID- 29832609
TI  - Around the Hospitals.

PMID- 29832610
TI  - The Treatment of Intestinal Obstruction.

PMID- 29832611
TI  - The Story of the Insane from Year to Year.

PMID- 29832612
TI  - Progress in Medicine.

PMID- 29832613
TI  - Gratitude to the Hospitals.

PMID- 29832614
TI  - Hereditary Neuroses in Children.-VII.

PMID- 29832615
TI  - Progress in Medicine.

PMID- 29832616
TI  - Hereditary Neuroses in Children.-VI.

PMID- 29832617
TI  - Technical Education.

PMID- 29832618
TI  - Medico-Legal Intelligence.

PMID- 29832619
TI  - Practical Observations on the Treatment of Common Deformities Caused by Rickets.

PMID- 29832620
TI  - The Means by Which the Temperature of the Body Is Maintained in Health and
      Disease: Lecture II.

PMID- 29832621
TI  - The Rontgen Society.

PMID- 29832622
TI  - Notes and News.

PMID- 29832623
TI  - Practical Points.

PMID- 29832624
TI  - Medical Science and the Anti-Vivisectionists.

PMID- 29832626
TI  - Hospital Sunday and the Queen's Commemoration.

PMID- 29832625
TI  - "The Hospital" Nursing Mirror.

PMID- 29832628
TI  - Hospital Reports.

PMID- 29832627
TI  - Progress in Surgery.

PMID- 29832629
TI  - Annotations.

PMID- 29832630
TI  - Off His Game.

PMID- 29832632
TI  - The Hospitals and Their Supporters in South London.

PMID- 29832631
TI  - New Appliances and Things Medical.

PMID- 29832634
TI  - Dermatology.

PMID- 29832633
TI  - Epidemiological Society.

PMID- 29832636
TI  - Practical Departments.

PMID- 29832635
TI  - On Renal Calculus.

PMID- 29832638
TI  - Progress in Medicine.

PMID- 29832637
TI  - Child Life under Queen Victoria: VIII. Ragged and Industrial Schools.

PMID- 29832639
TI  - The Serum Test for Typhoid Fever.

PMID- 29832640
TI  - Hospital Meetings, &c.

PMID- 29832642
TI  - The Story of the Insane from Year to Year.

PMID- 29832641
TI  - Royal Medical and Chirurgical Society.

PMID- 29832643
TI  - The Hospital Saturday Fund's System of Distribution.

PMID- 29832645
TI  - Annotations.

PMID- 29832644
TI  - Clinical Remarks on Vasectomy or Division of the Vasa Deferentia for Some Forms
      of Vesical Fistulae Associated with a Large Prostate.

PMID- 29832646
TI  - The Conveyance of Infection.

PMID- 29832647
TI  - Notes and News.

PMID- 29832648
TI  - Clinical Society.

PMID- 29832650
TI  - "The Hospital" Nursing Mirror.

PMID- 29832649
TI  - Delusional Insanity.

PMID- 29832651
TI  - Progress in Surgery.

PMID- 29832652
TI  - "The Hospital" to Its Readers.

PMID- 29832653
TI  - Construction Notes.

PMID- 29832654
TI  - State Control of Medical Practice.

PMID- 29832655
TI  - Hospital Meetings, &c.

PMID- 29832656
TI  - "The Hospital" Nursing Mirror.

PMID- 29832657
TI  - Progress in State Medicine.

PMID- 29832658
TI  - The Army Medical Service.

PMID- 29832659
TI  - Notes and News.

PMID- 29832660
TI  - Progress in Medicine.

PMID- 29832661
TI  - Child Life under Queen Victoria: IX. Canal-Boat Children.

PMID- 29832662
TI  - Editor's Letter-Box.

PMID- 29832663
TI  - Hospital Construction.

PMID- 29832664
TI  - The Surgical Uses of Anti-Streptococcic Serum.

PMID- 29832665
TI  - The Hospital Saturday Fund's Method of Distribution.

PMID- 29832666
TI  - Harveian Society.

PMID- 29832667
TI  - Some Points of Preventive Treatment in the Diseases of Women.

PMID- 29832669
TI  - The Specialist and the Practitioner.

PMID- 29832668
TI  - The Clinical Research Association.

PMID- 29832670
TI  - Surgical Aid Society.

PMID- 29832671
TI  - Progress in Surgery.

PMID- 29832672
TI  - Annotations.

PMID- 29832673
TI  - Progress in State Medicine.

PMID- 29832675
TI  - Annotations.

PMID- 29832674
TI  - Notes and News.

PMID- 29832677
TI  - Progress in Surgery.

PMID- 29832676
TI  - Remedies for Cancer.

PMID- 29832678
TI  - Progress in Gynaecology.

PMID- 29832679
TI  - Progress in Medicine.

PMID- 29832680
TI  - New Appliances and Things Medical.

PMID- 29832681
TI  - Clinical Society.

PMID- 29832682
TI  - "The Hospital" Nursing Mirror.

PMID- 29832683
TI  - Hospital Meetings, &c.

PMID- 29832685
TI  - The R.B.N.A. and Mental Nurses.

PMID- 29832684
TI  - A Question of Administration.

PMID- 29832686
TI  - Child Life under Queen Victoria: X. The Law and Education.

PMID- 29832687
TI  - The Hospital Saturday Fund's System of Distribution.

PMID- 29832688
TI  - Public Swimming Baths.

PMID- 29832689
TI  - Purification of Sewage.

PMID- 29832691
TI  - Notification of Measles.

PMID- 29832690
TI  - The Medical Council and the Apothecaries' Hall of Ireland.

PMID- 29832693
TI  - Medical Debts.

PMID- 29832692
TI  - Royal Medical and Chirurgical Society.

PMID- 29832694
TI  - The Medico-Psychological Society and Mental Nurses.

PMID- 29832695
TI  - Construction Notes.

PMID- 29832697
TI  - Endocarditis.

PMID- 29832696
TI  - The Council of the Royal College of Surgeons.

PMID- 29832698
TI  - "The Hospital" Nursing Mirror.

PMID- 29832699
TI  - Progress in Medicine.

PMID- 29832700
TI  - Medical Science in the Queen's Reign.

PMID- 29832701
TI  - Notes and News.

PMID- 29832702
TI  - Antiseptics in Medical Cases.

PMID- 29832703
TI  - Diphtheria and Anti-Toxin.

PMID- 29832704
TI  - Hospital Construction.

PMID- 29832705
TI  - Hereditary Neuroses in Children.-V.

PMID- 29832706
TI  - The Means by Which the Temperature of the Body Is Maintained in Health and
      Disease: Lecture I.

PMID- 29832707
TI  - Optic Neuritis in Typhoid Fever.

PMID- 29832708
TI  - Annotations.

PMID- 29832709
TI  - Special Hospital Sunday Supplement.

PMID- 29832710
TI  - Hospital Meetings, &c.

PMID- 29832712
TI  - New Appliances and Things Medical.

PMID- 29832711
TI  - Practical Observations on the Treatment of Common Deformities Caused by Rickets.

PMID- 29832713
TI  - What to Do with the Jubilee Stamps.

PMID- 29832714
TI  - Progress in Surgery.

PMID- 29832716
TI  - Notes and News.

PMID- 29832715
TI  - Progress in State Medicine.

PMID- 29832717
TI  - "The Hospital" Nursing Mirror.

PMID- 29832718
TI  - To Tap or to Explore?

PMID- 29832719
TI  - Annotations.

PMID- 29832720
TI  - Societies and Transactions.

PMID- 29832721
TI  - Hospital Meetings, &c.

PMID- 29832722
TI  - The Dangers of Hairdressing.

PMID- 29832724
TI  - Practical Points.

PMID- 29832723
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832725
TI  - Improved Accommodation for Inquests.

PMID- 29832726
TI  - Dandruff and Baldness.

PMID- 29832727
TI  - The Story of the Insane from Year to Year.

PMID- 29832728
TI  - Adaptation in Pathology.

PMID- 29832730
TI  - The Medical, Surgical, and Hygienic Exhibition.

PMID- 29832729
TI  - The Education of the Dairymaid.

PMID- 29832731
TI  - Progress in Medicine.

PMID- 29832732
TI  - Doctors in Camera.

PMID- 29832734
TI  - The London General Hospitals and the Central Hospital Board.

PMID- 29832733
TI  - Water Supply and Typhoid Fever.

PMID- 29832736
TI  - A Manoeuvre in Abdominal Surgery.

PMID- 29832735
TI  - Progress in Medicine.

PMID- 29832737
TI  - The Story of the Insane from Year to Year.

PMID- 29832738
TI  - Notes and News.

PMID- 29832740
TI  - New Appliances and Things Medical.

PMID- 29832739
TI  - An "Anti-Vivisection" Hospital.

PMID- 29832741
TI  - Construction Notes.

PMID- 29832742
TI  - Glycerinated Calf Lymph.

PMID- 29832743
TI  - Royal Medical and Chirurgical Society.

PMID- 29832744
TI  - Annotations.

PMID- 29832746
TI  - Asylum Construction.

PMID- 29832745
TI  - Hereditary Neuroses in Children.-IV.

PMID- 29832747
TI  - Lumbago.

PMID- 29832748
TI  - "The Hospital" Nursing Mirror.

PMID- 29832750
TI  - Medical Education in America.

PMID- 29832749
TI  - The New Light on the Nervous System.

PMID- 29832751
TI  - The Treatment of Gout by Hot Dry Air.

PMID- 29832752
TI  - Notes of Hospital Clinics.

PMID- 29832753
TI  - Progress in Surgery.

PMID- 29832754
TI  - Notes and News.

PMID- 29832755
TI  - Progress in Medicine.

PMID- 29832756
TI  - The Story of the Insane from Year to Year.

PMID- 29832758
TI  - The Prince of Wales's Hospital Fund for London.

PMID- 29832757
TI  - The Treatment of Fracture.

PMID- 29832759
TI  - Annotations.

PMID- 29832760
TI  - That Mystery-The Child.

PMID- 29832761
TI  - What Happens to All the Bromides?

PMID- 29832762
TI  - Hospital Construction.

PMID- 29832763
TI  - "The Hospital" Nursing Mirror.

PMID- 29832764
TI  - Verminous Persons.

PMID- 29832766
TI  - New Appliances and Things Medical.

PMID- 29832765
TI  - Epidemic Infantile Paralysis.

PMID- 29832767
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832768
TI  - The St. John Ambulance Association.

PMID- 29832770
TI  - Annotations.

PMID- 29832769
TI  - The Deep Effects of the "X" Rays.

PMID- 29832771
TI  - Notes and News.

PMID- 29832772
TI  - Fever Hospitals and the Profession.

PMID- 29832773
TI  - A Court Appointment.

PMID- 29832774
TI  - Progress in Medicine.

PMID- 29832775
TI  - Hospital Meetings, &c.

PMID- 29832776
TI  - Is the Plague Contagious?

PMID- 29832777
TI  - "The Hospital" Nursing Mirror.

PMID- 29832778
TI  - The Health of the Army in India.

PMID- 29832779
TI  - Erratum: Books Received.
AB  - [This corrects the article on p. 307 in vol. 22.].

PMID- 29832780
TI  - The Problems of Burial Insurance.

PMID- 29832781
TI  - A Jubilee Eviction.

PMID- 29832782
TI  - The Question of the Slaughter-Houses.

PMID- 29832783
TI  - Progress in Surgery.

PMID- 29832784
TI  - Progress in Medicine.

PMID- 29832785
TI  - The Perils of Medical Practice.

PMID- 29832787
TI  - Annotations.

PMID- 29832788
TI  - The Story of the Insane from Year to Year.

PMID- 29832786
TI  - The Increase in Lunacy.

PMID- 29832790
TI  - "The Hospital" Nursing Mirror.

PMID- 29832789
TI  - Hospital Meetings, &c.

PMID- 29832791
TI  - Notes and News.

PMID- 29832793
TI  - The Growth and Scope of Voluntary Hospital in London.

PMID- 29832792
TI  - Cholera Nostras and Cholera Asiatica.

PMID- 29832794
TI  - The Aseptic Finger as a Tourniquet.

PMID- 29832795
TI  - Hospital Meetings, &c.

PMID- 29832796
TI  - Practical Departments.

PMID- 29832797
TI  - The Prince of Wales's Hospital Fund for London.

PMID- 29832799
TI  - Epidemiological Society.

PMID- 29832798
TI  - The Suppression of Quackery.

PMID- 29832800
TI  - "The Hospital" Nursing Mirror.

PMID- 29832801
TI  - The Charity Organisation Society and the Hospitals.

PMID- 29832803
TI  - Annotations.

PMID- 29832802
TI  - The Prince and Princess See the Stamps Printed.

PMID- 29832805
TI  - Meeting at Marlborough House.

PMID- 29832804
TI  - The Session of the General Medical Council.

PMID- 29832807
TI  - In the Hospitals Sixty Years Ago.

PMID- 29832806
TI  - Progress in State Medicine.

PMID- 29832809
TI  - Notes and News.

PMID- 29832808
TI  - Periscope of Dermatology.

PMID- 29832811
TI  - Umbilical Sepsis.

PMID- 29832810
TI  - Progress in Surgery.

PMID- 29832812
TI  - Shelter for the Homeless.

PMID- 29832813
TI  - Treatment of Ulcers of the Leg by Scabbing.

PMID- 29832814
TI  - New Appliances and Things Medical.

PMID- 29832815
TI  - Counter Irritants in Sciatica.

PMID- 29832816
TI  - Hospitals for Measles-Infected Children.

PMID- 29832817
TI  - Notes and News.

PMID- 29832818
TI  - The Poor Man's Home.-XV: Housing in France (continued).

PMID- 29832819
TI  - The Prince of Wales's Hospital Fund.

PMID- 29832821
TI  - Hospital Construction.

PMID- 29832820
TI  - Periscope of Dermatology.

PMID- 29832823
TI  - Hospital Reform.

PMID- 29832822
TI  - Cardiac Pain and Angina Pectoris.

PMID- 29832824
TI  - Practical Departments.

PMID- 29832825
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832827
TI  - The Pollution of Water Supplies.

PMID- 29832826
TI  - The Diagnosis and Treatment of Diphtheria.

PMID- 29832828
TI  - "The Hospital" Nursing Mirror.

PMID- 29832829
TI  - The Royal British Nurses' Association.

PMID- 29832830
TI  - Medical Society: The Treatment of Pyo-pneumothorax.

PMID- 29832832
TI  - Annotations.

PMID- 29832831
TI  - Tuberculous Peritonitis.

PMID- 29832834
TI  - Annotations.

PMID- 29832833
TI  - Progress in Medicine.

PMID- 29832835
TI  - Reform of the Medical Acts.

PMID- 29832836
TI  - Hospital Construction.

PMID- 29832838
TI  - Progress in Medicine.

PMID- 29832837
TI  - A Lepers' Home.

PMID- 29832839
TI  - Notes and News.

PMID- 29832840
TI  - Mental Nursing.

PMID- 29832842
TI  - The Incidence of Plague on Different Classes.

PMID- 29832841
TI  - The Identification of Children at Fever Hospitals.

PMID- 29832844
TI  - The Prevention of Rabies.

PMID- 29832843
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832845
TI  - Progress in Surgery.

PMID- 29832846
TI  - The Poor Man's Home.-XX: Housing in Germany (continued).

PMID- 29832847
TI  - Complete Removal of the Stomach.

PMID- 29832848
TI  - "The Hospital" Nursing Mirror.

PMID- 29832849
TI  - New Appliances and Things Medical.

PMID- 29832850
TI  - The Maidstone Epidemic.

PMID- 29832851
TI  - The Recrudescence of Quarantine.

PMID- 29832852
TI  - A Tropical Poor House.

PMID- 29832854
TI  - The Outbreak of Typhoid at University College Hospital.

PMID- 29832853
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832856
TI  - Progress in Surgery.

PMID- 29832855
TI  - Annotations.

PMID- 29832857
TI  - A Lying-In Hospital for Leeds.

PMID- 29832858
TI  - "The Hospital" Nursing Mirror.

PMID- 29832860
TI  - Hospital Reform.

PMID- 29832859
TI  - Oophorectomy for Cancer.

PMID- 29832861
TI  - Practical Points.

PMID- 29832862
TI  - Varicose Veins and Their Complications.-II.

PMID- 29832863
TI  - New Appliances and Things Medical.

PMID- 29832864
TI  - Notes and News.

PMID- 29832865
TI  - The Initial Defect in Weak-Sighted Children.

PMID- 29832867
TI  - Hospital Administration.

PMID- 29832868
TI  - The Clinical Society.

PMID- 29832870
TI  - Vomiting While under an AEsthetics.

PMID- 29832869
TI  - On the Investigation of Some of the Nervous Disorders of the Heart.

PMID- 29832872
TI  - Typhoid Fever and London Water.

PMID- 29832871
TI  - The Poor Man's Home.-IX: The Municipal Landlord.

PMID- 29832873
TI  - Boils, Carbuncles, and Whitlows.

PMID- 29832874
TI  - The Local Government Board on Country Water Supplies.

PMID- 29832876
TI  - Diphtheria Anti-Toxin in Epidemic Measles.

PMID- 29832875
TI  - Progress in Ophthalmology.

PMID- 29832878
TI  - The New Pharmacopoeia.

PMID- 29832877
TI  - Progress in Surgery.

PMID- 29832879
TI  - The Diminishing Mortality from Infectious Diseases.

PMID- 29832880
TI  - Sequelae of Typhoid Fever.

PMID- 29832881
TI  - Sterilisation by "Frying".

PMID- 29832882
TI  - The Treatment of Measles a "Mere Matter of Routine".

PMID- 29832884
TI  - Notes and News.

PMID- 29832883
TI  - "The Hospital" Nursing Mirror.

PMID- 29832886
TI  - New Appliances and Things Medical.

PMID- 29832885
TI  - Hospital Meetings, &c.

PMID- 29832887
TI  - Annotations.

PMID- 29832888
TI  - Progress in State Medicine.

PMID- 29832890
TI  - The Hospitals on Christmas Day.

PMID- 29832889
TI  - The Poor Man's Home.-XXI: Housing in Germany (concluded).

PMID- 29832891
TI  - Fever Instruction at the Metropolitan Asylums Board Hospitals.

PMID- 29832892
TI  - Buildings and Fittings in the Older Hospitals.

PMID- 29832893
TI  - Prince of Wales's Hospital Fund.

PMID- 29832894
TI  - "The Hospital" Nursing Mirror.

PMID- 29832896
TI  - Editor's Letter-Box.

PMID- 29832895
TI  - Progress in Medicine.

PMID- 29832898
TI  - Progress in Surgery.

PMID- 29832897
TI  - Annotations.

PMID- 29832900
TI  - Alcohol and Cirrhosis.

PMID- 29832899
TI  - Notes and News.

PMID- 29832901
TI  - 1897: A Retrospect.

PMID- 29832902
TI  - Workhouse Infirmaries.

PMID- 29832903
TI  - New Appliances and Things Medical.

PMID- 29832904
TI  - Unqualified Medical "Assistants".

PMID- 29832906
TI  - Hospital Construction.

PMID- 29832905
TI  - Reciprocity in Medicine.

PMID- 29832907
TI  - Infection by Third Persons.

PMID- 29832908
TI  - Asylum Construction.

PMID- 29832909
TI  - The General Medical Council.

PMID- 29832910
TI  - "The Hospital" Nursing Mirror.

PMID- 29832912
TI  - Clinical Society.

PMID- 29832911
TI  - Editor's Letter-Box.

PMID- 29832913
TI  - Hospitals and Their Detractors.

PMID- 29832914
TI  - A Woman's Reason.

PMID- 29832916
TI  - Deaths from Chloroform.

PMID- 29832915
TI  - New Appliances and Things Medical.

PMID- 29832917
TI  - Cardiac Pain and Angina Pectoris.

PMID- 29832918
TI  - Moveable Kidney.

PMID- 29832920
TI  - Notes and News.

PMID- 29832919
TI  - Progress in Medicine.

PMID- 29832921
TI  - The Story of the Insane from Year to Year.

PMID- 29832922
TI  - The Poor Man's Home.-XVI: Housing in France (concluded).

PMID- 29832923
TI  - Annotations.

PMID- 29832924
TI  - Hospital Reform.

PMID- 29832925
TI  - British Laryngological, Rhinological, and Otological Association.

PMID- 29832926
TI  - Hospital Reform.

PMID- 29832928
TI  - "The Hospital" Nursing Mirror.

PMID- 29832927
TI  - Periscope of Dermatology.

PMID- 29832929
TI  - Hospital Construction.

PMID- 29832930
TI  - Annotations.

PMID- 29832931
TI  - Guardians and Operation Fees.

PMID- 29832932
TI  - Facts and Principles as to Hospital Reform.

PMID- 29832934
TI  - New Appliances and Things Medical.

PMID- 29832933
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832936
TI  - Progress in Surgery.

PMID- 29832935
TI  - Gynaecology in General Practice.

PMID- 29832938
TI  - Clinical Society.

PMID- 29832937
TI  - Notes and News.

PMID- 29832939
TI  - The Poor Man's Home.-XIV: Housing in France.

PMID- 29832941
TI  - Progress in Medicine.

PMID- 29832940
TI  - Cardiac Pain and Angina Pectoris.

PMID- 29832943
TI  - Granular Kidney and Vascular Changes.

PMID- 29832942
TI  - Hospital Meetings, &c.

PMID- 29832945
TI  - Successful Ovariotomy in a Child Four Months Old.

PMID- 29832944
TI  - New Appliances and Things Medical.

PMID- 29832946
TI  - The Patient Insisted upon Under-Going Abdominal Section!

PMID- 29832947
TI  - Pain in the Ear: II. Its Treatment.

PMID- 29832948
TI  - The Open-Air Treatment of Phthisis in England.

PMID- 29832949
TI  - Annotations.

PMID- 29832951
TI  - Notes.

PMID- 29832950
TI  - Hospital Meetings, &c.

PMID- 29832953
TI  - The Frequency of Extra-Uterine Pregnancy.

PMID- 29832952
TI  - Erratum.
AB  - [This corrects the article on p. 392 in vol. 23.].

PMID- 29832955
TI  - The Proposed London University.

PMID- 29832954
TI  - Progress in Surgery.

PMID- 29832956
TI  - The Story of the Insane from Year to Year.

PMID- 29832957
TI  - The Curative Influence of Exploratory Incisions.

PMID- 29832959
TI  - Prison Training and Administration.

PMID- 29832958
TI  - Chloroform and Polemics.

PMID- 29832960
TI  - "The Hospital" Nursing Mirror.

PMID- 29832961
TI  - The Extravagance of Small Fever Hospitals.

PMID- 29832963
TI  - Notes and News.

PMID- 29832962
TI  - Progress in Medicine.

PMID- 29832964
TI  - Thyroid Extract for Backward Children.

PMID- 29832965
TI  - Economics of Philanthropy.

PMID- 29832967
TI  - The London School Board.

PMID- 29832966
TI  - Within the Hospitals.

PMID- 29832969
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29832968
TI  - Notes and News.

PMID- 29832970
TI  - The Royal College of Surgeons of England.

PMID- 29832971
TI  - The Poor Man's Home.-X: The Municipal Landlord (continued).

PMID- 29832972
TI  - "The Hospital" Nursing Mirror.

PMID- 29832973
TI  - Progress in Medicine.

PMID- 29832974
TI  - The Harveian Oration.

PMID- 29832975
TI  - New Appliances and Things Medical.

PMID- 29832976
TI  - Annotations.

PMID- 29832977
TI  - Microbes and Internal Medication.

PMID- 29832979
TI  - Secondary Typhoid.

PMID- 29832978
TI  - Progress in Surgery.

PMID- 29832980
TI  - The Swansea Hospital.

PMID- 29832981
TI  - Vaginal Douching after Parturition.

PMID- 29832982
TI  - Chilly Churches.

PMID- 29832983
TI  - The Hospital Nursing Supplement.

PMID- 29832985
TI  - Around the Hospitals.

PMID- 29832984
TI  - Treatment of Simple Fracture of the Femur.

PMID- 29832986
TI  - The Social Horizon.

PMID- 29832987
TI  - Medical History from the Earliest Times: XLVIII.-Paracelsus.

PMID- 29832989
TI  - The Treatment of Pleural Effusion.

PMID- 29832988
TI  - Construction Notes.

PMID- 29832990
TI  - Annotations.

PMID- 29832991
TI  - New Drugs, Appliances, and Things Medical: Milled Toilet Soads.

PMID- 29832993
TI  - Gleanings in Science and Medicine.

PMID- 29832992
TI  - Experiment and Experience.

PMID- 29832994
TI  - Contemporary Theory and Research.

PMID- 29832995
TI  - Notes and News.

PMID- 29832996
TI  - Diet in Disease: XVIII.-Indigestion.

PMID- 29832998
TI  - Notes and News.

PMID- 29832997
TI  - The Poor Man's Home.-XVII: Housing in America.

PMID- 29833000
TI  - Hospital Meetings, &c.

PMID- 29832999
TI  - Free Speech at Medical Societies.

PMID- 29833002
TI  - Endemic Typhoid.

PMID- 29833001
TI  - The Story of the Insane from Year to Year.

PMID- 29833004
TI  - Annotations.

PMID- 29833003
TI  - Milk Diet.

PMID- 29833006
TI  - Periscope of Dermatology.

PMID- 29833005
TI  - Wild Beasts and Snakes.

PMID- 29833008
TI  - "The Hospital" Nursing Mirror.

PMID- 29833007
TI  - Progress in Medicine.

PMID- 29833009
TI  - The Unqualified Assistant: The Other Side.

PMID- 29833010
TI  - Progress in Surgery.

PMID- 29833011
TI  - Asylum Construction.

PMID- 29833012
TI  - Tuberculous Peritonitis.

PMID- 29833013
TI  - The Notification Act.

PMID- 29833014
TI  - "The Hospital" Nursing Mirror.

PMID- 29833016
TI  - Progress in Surgery.

PMID- 29833015
TI  - Annotations.

PMID- 29833017
TI  - Foreign Bodies in the Air Passages.

PMID- 29833018
TI  - What Do General Practitioners Want?

PMID- 29833020
TI  - Notes and News.

PMID- 29833019
TI  - The Poor Man's Home.-VII: "Philanthropy and 4 per cent".

PMID- 29833021
TI  - Typhoid Fever at Maidstone.

PMID- 29833022
TI  - Operations on the Insane.

PMID- 29833024
TI  - Hospital Construction.

PMID- 29833023
TI  - The Growth and Scope of Voluntary Hospitals in London.

PMID- 29833025
TI  - Progress in Medicine.

PMID- 29833026
TI  - Public Health.

PMID- 29833028
TI  - The Climatic Treatment of Phthisis.

PMID- 29833027
TI  - Notes of Hospital Clinics.

PMID- 29833029
TI  - Progress in Medicine.

PMID- 29833030
TI  - British Orthopaedic Society.

PMID- 29833031
TI  - Progress in Surgery.

PMID- 29833032
TI  - Charing Cross Hospital.

PMID- 29833033
TI  - The County Infirmary, Leicester.

PMID- 29833034
TI  - Medical Society.

PMID- 29833035
TI  - Winter Quarters.

PMID- 29833036
TI  - Annotations.

PMID- 29833037
TI  - The Poor Man's Home.-XIII: Master and Man (concluded).

PMID- 29833038
TI  - The Mechanics of Defaecation.

PMID- 29833039
TI  - Royal Medical and Chirurgical Society.

PMID- 29833040
TI  - The Inauguration of the Rontgen Society.

PMID- 29833041
TI  - The Glasgow Western Infirmary.

PMID- 29833042
TI  - Cardiac Pain and Angina Pectoris.

PMID- 29833044
TI  - "The Hospital" Nursing Mirror.

PMID- 29833043
TI  - Notes and News.

PMID- 29833046
TI  - Hospital Meetings, &c.

PMID- 29833045
TI  - New Appliances and Things Medical.

PMID- 29833047
TI  - New Appliances and Things Medical.

PMID- 29833048
TI  - "The Hospital" Nursing Mirror.

PMID- 29833049
TI  - Annotations.

PMID- 29833050
TI  - Notes from Australia.

PMID- 29833051
TI  - A Case of Pneumonia with Cerebral Complications.

PMID- 29833052
TI  - Hospital Construction.

PMID- 29833054
TI  - Quack Medicines.

PMID- 29833053
TI  - Progress in Medicine.

PMID- 29833055
TI  - Influenza.

PMID- 29833056
TI  - Deaths from Anaesthetics.

PMID- 29833057
TI  - The Story of the Insane from Year to Year.

PMID- 29833058
TI  - The Poor Man's Home.-XXV.

PMID- 29833059
TI  - Our Position on the Vivisection Question.

PMID- 29833060
TI  - Nasal Polypi and Their Treatment.

PMID- 29833062
TI  - Economics of Philanthropy.

PMID- 29833061
TI  - Progress in Surgery.

PMID- 29833064
TI  - Prince of Wales's Hospital Fund.

PMID- 29833063
TI  - Notes and News.

PMID- 29833066
TI  - Progress in Medicine.

PMID- 29833065
TI  - The Combination of Antagonistic Drugs.

PMID- 29833067
TI  - Two Cases of Operation on the Kidney.

PMID- 29833069
TI  - Milk Laboratories.

PMID- 29833068
TI  - "The Hospital" Nursing Mirror.

PMID- 29833071
TI  - The Colonial Lunatic Asylum, Berbice.

PMID- 29833070
TI  - Glycerinated Vaccine Lymph.

PMID- 29833073
TI  - Notes and News.

PMID- 29833072
TI  - Post-Mortem Examinations on Hospital Patients.

PMID- 29833074
TI  - Hospital Construction.

PMID- 29833075
TI  - The Treatment of Ulcers of the Cornea in Children.

PMID- 29833076
TI  - New Appliances and Things Medical.

PMID- 29833077
TI  - The Poor Man's Home.-XIX: Housing in Germany.

PMID- 29833079
TI  - Wounds of the Heart.

PMID- 29833080
TI  - Annotations.

PMID- 29833078
TI  - Progress in Surgery.

PMID- 29833081
TI  - The Serum Treatment of Yellow Fever.

PMID- 29833082
TI  - Ear Disease and "Head Symptoms" in Infants.

PMID- 29833083
TI  - The Out-Patient Problem.

PMID- 29833084
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29833085
TI  - Royal Medical and Chirurgical Society.

PMID- 29833086
TI  - The Pathological Society.

PMID- 29833087
TI  - Vaccination against Typhoid Fever.

PMID- 29833088
TI  - The Poor Man's Home.-XI: Master and Man.

PMID- 29833089
TI  - The Neuron and Disease.

PMID- 29833090
TI  - New Appliances and Things Medical.

PMID- 29833091
TI  - Annotations.

PMID- 29833093
TI  - Hospital Reform.

PMID- 29833092
TI  - Notes and News.

PMID- 29833095
TI  - Early Vaginal Incision in Septic Pelvic Disease.

PMID- 29833094
TI  - Progress in Surgery.

PMID- 29833097
TI  - "The Hospital" Nursing Mirror.

PMID- 29833096
TI  - Medical Society.

PMID- 29833098
TI  - The Hospital Reform Association.

PMID- 29833099
TI  - Progress in Medicine.

PMID- 29833100
TI  - Annotations.

PMID- 29833101
TI  - Royal Medical and Chirurgical Society.

PMID- 29833102
TI  - Muzzling or Rabies.

PMID- 29833103
TI  - Notes and News.

PMID- 29833104
TI  - "The Hospital" Nursing Mirror.

PMID- 29833105
TI  - Prosperity and Cancer.

PMID- 29833107
TI  - New Appliances and Things Medical.

PMID- 29833106
TI  - A Knock-Out Blow.

PMID- 29833108
TI  - Christmas Appeal Supplement.

PMID- 29833109
TI  - Hospital Construction.

PMID- 29833111
TI  - Progress in Medicine.

PMID- 29833110
TI  - On Two Cases of Hysteria.

PMID- 29833113
TI  - The Story of the Insane from Year to Year.

PMID- 29833112
TI  - Hospital Meetings, &c.

PMID- 29833114
TI  - Hospital Construction.

PMID- 29833115
TI  - The Poor Man's Home.-XVIII: Housing in America (concluded).

PMID- 29833117
TI  - Devizes Hospital Collection.

PMID- 29833116
TI  - Progress in Surgery.

PMID- 29833119
TI  - The Mental Side of the Sense of Hearing.

PMID- 29833118
TI  - Progress in Medicine.

PMID- 29833121
TI  - Relapse in Typhoid Fever.

PMID- 29833120
TI  - "The Hospital" Nursing Mirror.

PMID- 29833122
TI  - Training the Sight.

PMID- 29833123
TI  - Annotations.

PMID- 29833124
TI  - Economics of Philanthropy.

PMID- 29833125
TI  - The Debate on Cancer of the Breast.

PMID- 29833126
TI  - Notes and News.

PMID- 29833127
TI  - Progress in Surgery.

PMID- 29833129
TI  - Heredity in Regard to Length of Life.

PMID- 29833130
TI  - The Story of the Insane from Year to Year.

PMID- 29833131
TI  - Hospital Meetings, &c.

PMID- 29833132
TI  - The Poor Man's Home.-XXVIII: Conclusion.

PMID- 29833133
TI  - Creasote as an Internal Antiseptic.

PMID- 29833134
TI  - The Midwife Difficulty in New York.

PMID- 29833135
TI  - Zymotic Death-Rates in 1897.

PMID- 29833136
TI  - Notes.

PMID- 29833137
TI  - Pain in the Ear.

PMID- 29833138
TI  - Whooping-Cough Cases in Children's Hospitals.

PMID- 29833140
TI  - A Defect in Medical Education.

PMID- 29833139
TI  - "The Hospital" Nursing Mirror.

PMID- 29833141
TI  - Notes and News.

PMID- 29833142
TI  - Annotations.

PMID- 29833143
TI  - The Story of the Insane from Year to Year.

PMID- 29833144
TI  - The Growth Scope of Voluntary Hospitals in London.

PMID- 29833145
TI  - Medical M.P.s at Work.

PMID- 29833146
TI  - Introductory Addresses.

PMID- 29833147
TI  - General Hospitals and Infectious Diseases.

PMID- 29833148
TI  - Progress in Medicine.

PMID- 29833149
TI  - The Medical Session.

PMID- 29833151
TI  - Progress in Surgery.

PMID- 29833150
TI  - Varicose Veins and Their Complications.-I.

PMID- 29833153
TI  - Notes.

PMID- 29833152
TI  - The Poor Man's Home.-VIII: "Philanthropy and 4 per cent" (continued).

PMID- 29833155
TI  - Notes and News.

PMID- 29833154
TI  - Nursing in Rural Districts.

PMID- 29833156
TI  - Expert Witnesses.

PMID- 29833157
TI  - Hospital Meetings, &c.

PMID- 29833159
TI  - Economics of Philanthropy.

PMID- 29833158
TI  - Subphrenic Abscess.

PMID- 29833161
TI  - Radiant Heat for the Relief of Pain.

PMID- 29833160
TI  - New Appliances and Things Medical.

PMID- 29833163
TI  - An Abnormal Case of Pneumonia.

PMID- 29833162
TI  - Progress in Surgery.

PMID- 29833164
TI  - Operations on the Liver.

PMID- 29833165
TI  - "The Hospital" Nursing Mirror.

PMID- 29833166
TI  - Annotations.

PMID- 29833167
TI  - Two Points in Administering Anaesthetics.

PMID- 29833169
TI  - Retention and Extravasation of Urine in Children.

PMID- 29833168
TI  - Prison Administration and the Training of Prison Officials.-II.

PMID- 29833170
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29833171
TI  - Harveian Society.

PMID- 29833172
TI  - Around the Hospitals.

PMID- 29833173
TI  - Progress in Medicine.

PMID- 29833174
TI  - The Hospitals Association.

PMID- 29833175
TI  - The "Peculiar People".

PMID- 29833176
TI  - New Appliances and Things Medical.

PMID- 29833177
TI  - Annotations.

PMID- 29833179
TI  - Clinical Society.

PMID- 29833178
TI  - Varicose Veins and Their Complications.-III.

PMID- 29833181
TI  - Notes and News.

PMID- 29833180
TI  - "The Hospital" Nursing Mirror.

PMID- 29833182
TI  - Laying the Foundation-Stone of the Children's Convalescent Home, Bognor.

PMID- 29833183
TI  - Metropolitan Hospital Saturday Fund and Street Collections.

PMID- 29833184
TI  - The Poor Man's Home.-XII: Master and Man (continued).

PMID- 29833185
TI  - Cleanliness.

PMID- 29833186
TI  - Scarlet Fever.

PMID- 29833187
TI  - The North London Hospital for Consumption.

PMID- 29833189
TI  - Invalid Chairs, II.

PMID- 29833188
TI  - The Hospital Nursing Supplement.

PMID- 29833190
TI  - Children's Hospitals in East London.

PMID- 29833191
TI  - The Proposed Central Hospitals Board for London.

PMID- 29833193
TI  - The East London Hospital for Children.

PMID- 29833192
TI  - Annotations.

PMID- 29833194
TI  - Gleanings in Science and Medicine.

PMID- 29833195
TI  - Equal Service, Equal Honour.

PMID- 29833196
TI  - Medical History from the Earliest Times: LII.-Medical Practice in the Sixteenth
      Century.

PMID- 29833197
TI  - Around the Hospitals.

PMID- 29833198
TI  - Notes and News.

PMID- 29833199
TI  - Contemporary Theory and Research.

PMID- 29833200
TI  - The Treatment of Rhinitis.

PMID- 29833202
TI  - Construction Notes.

PMID- 29833201
TI  - Treatment of Simple Fractures of the Femur.

PMID- 29833204
TI  - The Redcliffe Infirmary, Oxford.

PMID- 29833203
TI  - Great Achievements under Suffering: I. Prof. H. Fawcett.

PMID- 29833205
TI  - Operations on Hysterical Patients.

PMID- 29833206
TI  - Notes and News.

PMID- 29833208
TI  - The Vaccination Bill.

PMID- 29833207
TI  - Operations on the Liver.

PMID- 29833209
TI  - Mr. Leonard Hill on Dr. Lauder Brunton.

PMID- 29833210
TI  - Hospital Meetings, &c.

PMID- 29833212
TI  - Progress in Medicine.

PMID- 29833211
TI  - "The Hospital" Nursing Mirror.

PMID- 29833214
TI  - The Mother in the Factory.

PMID- 29833213
TI  - The Private Clinic.

PMID- 29833216
TI  - Certificates of the Cause of Death.

PMID- 29833215
TI  - Uric Acid.

PMID- 29833217
TI  - Notes.

PMID- 29833218
TI  - New Appliances and Things Medical.

PMID- 29833220
TI  - Dr. Playfair on Mediaevalism at the Royal Colleges.

PMID- 29833219
TI  - Perforating Wounds of the Knee Joint.

PMID- 29833222
TI  - Progress in Surgery.

PMID- 29833221
TI  - Sunstroke.

PMID- 29833224
TI  - Annotations.

PMID- 29833223
TI  - A Very Complete Hysterectomy.

PMID- 29833226
TI  - Smoke-Consuming Stoves.

PMID- 29833225
TI  - The London Poor and Their Medical Needs.

PMID- 29833228
TI  - Gleanings in Science and Medicine.

PMID- 29833227
TI  - Annotations.

PMID- 29833229
TI  - Contemporary Theory and Research.

PMID- 29833230
TI  - The Hospital Nursing Supplement.

PMID- 29833231
TI  - The Treatment of Acute Rheumatism.

PMID- 29833232
TI  - Notes and News.

PMID- 29833233
TI  - Around the Hospitals.

PMID- 29833234
TI  - Prescribing in the Dark.

PMID- 29833236
TI  - New Hospital for Children at Leipzig.

PMID- 29833235
TI  - Medical History from the Earliest Times: XLIX.-Similars, Sympathy, and
      Signatures.

PMID- 29833237
TI  - Diet in Disease: XIX.-Indigestion.

PMID- 29833239
TI  - The Treatment of Flat Foot, Bow Legs, and Knock Knee.

PMID- 29833238
TI  - Treatment of Fractured Patella.

PMID- 29833240
TI  - Construction Notes.

PMID- 29833241
TI  - New Drugs, Appliances, and Things Medical: A New Laundry Soap.

PMID- 29833242
TI  - The Treatment of Cold Abscess.

PMID- 29833243
TI  - The Treatment of Club Foot.

PMID- 29833244
TI  - School Hygiene.

PMID- 29833245
TI  - Around the Hospitals.

PMID- 29833247
TI  - The Hospital Nursing Supplement.

PMID- 29833246
TI  - Construction Notes.

PMID- 29833249
TI  - Medical History from the Earliest Times: L.-The Great Anatomists.

PMID- 29833248
TI  - Hospitals of the World: IV.-Nursing Systems Abroad.

PMID- 29833251
TI  - Notes and News.

PMID- 29833250
TI  - Gleanings in Science and Medicine.

PMID- 29833253
TI  - Contemporary Theory and Research.

PMID- 29833252
TI  - Annotations.

PMID- 29833255
TI  - Fire Escapes.

PMID- 29833254
TI  - Nebuchadnezzar's Feast.

PMID- 29833257
TI  - Special Journals for Hospital Saturday Funds.

PMID- 29833256
TI  - New Drugs. Appliances, and Things Medical.

PMID- 29833258
TI  - Hospital Accounts.

PMID- 29833259
TI  - Annotations.

PMID- 29833260
TI  - Hints to Practitioners.

PMID- 29833261
TI  - The Bacillus of Plague.

PMID- 29833263
TI  - Notes and News.

PMID- 29833262
TI  - The Action of Alcohol in Acute Disease.

PMID- 29833264
TI  - Drunk or Dying.

PMID- 29833265
TI  - Progress in Surgery.

PMID- 29833267
TI  - New Appliances and Things Medical.

PMID- 29833266
TI  - Hospital Reform : A Reverie.

PMID- 29833268
TI  - "The Hospital" Nursing Mirror.

PMID- 29833269
TI  - Modern Operations for Cancer.

PMID- 29833271
TI  - The Reorganisation of the University of London.

PMID- 29833270
TI  - The Poor Man's Home.-XXIII: Model Lodging-Houses.

PMID- 29833272
TI  - Hospitals and Vivisection.

PMID- 29833273
TI  - Progress in Medicine.

PMID- 29833274
TI  - Deaths from Anaesthetics.

PMID- 29833275
TI  - Victoria House, Chalfont St. Peter.

PMID- 29833277
TI  - The Diamond Jubilee and the Hospitals.

PMID- 29833276
TI  - The Prevention of Measles.

PMID- 29833279
TI  - The Hospitals Association.

PMID- 29833278
TI  - The Diagnosis of Syphilitic Skin Affections.

PMID- 29833280
TI  - Annotations.

PMID- 29833281
TI  - Contemporary Theory and Research.

PMID- 29833282
TI  - Construction Notes.

PMID- 29833283
TI  - Antitoxic Serum in Tetanus.

PMID- 29833284
TI  - The Treatment of Stone in the Bladder.

PMID- 29833285
TI  - The Memorial Hospital, Mirfield.

PMID- 29833287
TI  - Notes and News.

PMID- 29833286
TI  - Famous Poisoners in Fiction: II. A Daughter of Darkness.

PMID- 29833288
TI  - The Work of the Hospitals Association.

PMID- 29833289
TI  - Fighting the Microbe.

PMID- 29833291
TI  - Treatment of Pulmonary Phthisis: II. Chronic Phthisis.

PMID- 29833290
TI  - Around the Hospitals.

PMID- 29833293
TI  - The Hospital Nursing Supplement.

PMID- 29833292
TI  - Great Achievements under Suffering: II. The Blind Poet.

PMID- 29833294
TI  - Duodenal Indigestion.

PMID- 29833295
TI  - The Story of the Insane from Year to Year.

PMID- 29833296
TI  - The Hospital Nursing Supplement.

PMID- 29833297
TI  - Notes and News.

PMID- 29833299
TI  - Three Cottage Hospitals.

PMID- 29833298
TI  - L.K. Batteries.

PMID- 29833300
TI  - Annotations.

PMID- 29833301
TI  - New Drugs, Appliances, and Things Medical: Malto-Pepsine.

PMID- 29833303
TI  - The Treatment of Abscesses.

PMID- 29833302
TI  - How to Keep Well in Africa: I. Prevention.

PMID- 29833305
TI  - Why Do Doctors Not Advertise?

PMID- 29833304
TI  - Rhinoscopy.

PMID- 29833306
TI  - Contemporary Theory and Research.

PMID- 29833307
TI  - The Orphan Working School, Haverstock Hill.

PMID- 29833308
TI  - The Story of the Insane from Year to Year.

PMID- 29833310
TI  - Gleanings in Science and Medicine.

PMID- 29833309
TI  - The Surgical Treatment of Gallstones.

PMID- 29833311
TI  - The North-Eastern Hospital for Children.

PMID- 29833312
TI  - Construction Notes.

PMID- 29833314
TI  - British Home for Incurables, Clapham.

PMID- 29833313
TI  - Around the Hospitals.

PMID- 29833316
TI  - Annotations.

PMID- 29833315
TI  - Medical History from the Earliest Times: LIV.-Van Helmont.

PMID- 29833318
TI  - Notes and News.

PMID- 29833317
TI  - The Poor Man's Home.-XXII: Patching Up Old Property.

PMID- 29833319
TI  - Posture in Percussion of the Heart.

PMID- 29833320
TI  - A Short Way with Anti-Vaccinators.

PMID- 29833322
TI  - Responsibility of the Insane.

PMID- 29833321
TI  - Typhoid Fever and Its Prevention.

PMID- 29833324
TI  - Progress in Surgery.

PMID- 29833323
TI  - Constipation and the Corset.

PMID- 29833326
TI  - The Legal Control of "Dispensaries" in New York.

PMID- 29833325
TI  - "The Hospital" Nursing Mirror.

PMID- 29833327
TI  - New Appliances and Things Medical.

PMID- 29833328
TI  - Hospital Reform Association.

PMID- 29833330
TI  - The Workmen's Compensation Act, 1897.

PMID- 29833329
TI  - Progress in Ophthalmology.

PMID- 29833331
TI  - Vaccination in Germany.

PMID- 29833332
TI  - The Diamond Jubilee and the Hospitals.

PMID- 29833333
TI  - Hints to Practitioners.

PMID- 29833334
TI  - Progress in State Medicine.

PMID- 29833336
TI  - Construction Notes.

PMID- 29833335
TI  - Influenza in Children.

PMID- 29833337
TI  - The North-Eastern Hospital for Children.

PMID- 29833338
TI  - The Hospital Nursing Supplement.

PMID- 29833339
TI  - The Drink Question in Switzerland.

PMID- 29833340
TI  - Gleanings in Science and Medicine.

PMID- 29833341
TI  - The Richmond Hospital.

PMID- 29833342
TI  - New Drugs. Appliances, and Things Medical: New Sponge-Holding Electrode.

PMID- 29833343
TI  - Recreation for Middle Age.

PMID- 29833344
TI  - Around the Hospitals.

PMID- 29833345
TI  - The Treatment of Injuries to the Scalp.

PMID- 29833346
TI  - Treatment of Tubercular Joints.

PMID- 29833347
TI  - The Metropolitan Hospital.

PMID- 29833348
TI  - Notes and News.

PMID- 29833349
TI  - Senile Gangrene.

PMID- 29833350
TI  - Leith Fever Hospital.

PMID- 29833352
TI  - Annotations.

PMID- 29833351
TI  - Contemporary Theory and Research.

PMID- 29833353
TI  - Cheshire County Asylum at Macclesfield.

PMID- 29833354
TI  - Medical History from the Earliest Times: LIII.-Harvey and the New Physiology.

PMID- 29833355
TI  - Diet in Disease: XXV.-On Thinning and Fattening.

PMID- 29833356
TI  - Medical History from the Earliest Times: LX.-The Vitalists.

PMID- 29833357
TI  - Around the Hospitals.

PMID- 29833358
TI  - Notes and News.

PMID- 29833359
TI  - Annotations.

PMID- 29833360
TI  - Gleanings in Science and Medicine.

PMID- 29833361
TI  - The Treatment of Fractures of the Nose.

PMID- 29833362
TI  - The Royal Wedding.

PMID- 29833363
TI  - Furniture for Nurses' Rooms.

PMID- 29833365
TI  - Festival Dinners and Meetings.

PMID- 29833364
TI  - The Newcastle Eye Infirmary.

PMID- 29833366
TI  - New Appliances and Things Medical: Messrs. Allen and Hanbury's Preparations.

PMID- 29833367
TI  - The Treatment of Scarlet Fever by Antiseptic Inunction.

PMID- 29833368
TI  - Some Simple Uses of Carbolic Acid. I.

PMID- 29833370
TI  - Contemporary Theory and Research.

PMID- 29833369
TI  - The Naphthols as Intestinal Anti-Infectants.

PMID- 29833371
TI  - Construction Notes.

PMID- 29833372
TI  - The Hospital Nursing Supplement.

PMID- 29833373
TI  - Gleanings in Science and Medicine.

PMID- 29833374
TI  - Analgen.

PMID- 29833375
TI  - Contemporary Theory and Research.

PMID- 29833376
TI  - Notes and News.

PMID- 29833377
TI  - Treatment of Tonsillitis.

PMID- 29833378
TI  - The Treatment of Tubercular Enteritis.

PMID- 29833379
TI  - Physical Education.

PMID- 29833380
TI  - Treatment of Hammer Toe.

PMID- 29833381
TI  - The Hospital Nursing Supplement.

PMID- 29833382
TI  - Great Achievements under Suffering: III. The Deaf Musician.

PMID- 29833383
TI  - Annotations.

PMID- 29833384
TI  - Hospital Meetings.

PMID- 29833385
TI  - The Baby: Its Manners and Its Morals.

PMID- 29833386
TI  - Around the Hospitals.

PMID- 29833387
TI  - Workers and Weariness.

PMID- 29833388
TI  - Special Hospitals: III. Children's.

PMID- 29833390
TI  - Notes and News.

PMID- 29833389
TI  - Fish and Cholera.

PMID- 29833391
TI  - Dental Schools in London.

PMID- 29833392
TI  - From Chemist's Shop to Physic's Throne.

PMID- 29833393
TI  - Metropolitan Medical Schools.

PMID- 29833394
TI  - Annotations.

PMID- 29833395
TI  - Metropolitan Medical Schools and Their Common Interests.

PMID- 29833396
TI  - The Hospital Nursing Supplement.

PMID- 29833398
TI  - The Cost of a Medical Education.

PMID- 29833397
TI  - How a Lady May Become a Doctor.

PMID- 29833399
TI  - New Appliances and Things Medical.

PMID- 29833400
TI  - The Late Surgeon-Major Parke.

PMID- 29833401
TI  - Medical Education in Scotland.

PMID- 29833402
TI  - Society for the Study of Inebriety.

PMID- 29833403
TI  - Notes and News.

PMID- 29833404
TI  - Gleanings in Science and Medicine.

PMID- 29833405
TI  - Around the Hospitals.

PMID- 29833406
TI  - Annotations.

PMID- 29833407
TI  - Disinfection of Scarlet Fever by Antiseptic Inunction.

PMID- 29833409
TI  - Poplar Hospital for Accidents.

PMID- 29833408
TI  - Medical History from the Earliest Times: LXII.-The Surgery of the Eighteenth
      Century.

PMID- 29833411
TI  - North London Hospital for Consumption.

PMID- 29833410
TI  - The Relations of Hospitals to Public Health.

PMID- 29833412
TI  - Belle Vue Hospital, New York.

PMID- 29833413
TI  - Ward Waggons.

PMID- 29833414
TI  - Chamber Portable Closet.

PMID- 29833415
TI  - National Dental Hospital.

PMID- 29833416
TI  - The Hospital Nursing Supplement.

PMID- 29833417
TI  - Grindelia Robusta in Asthma and Chronic Bronchitis.

PMID- 29833418
TI  - Construction Notes: Additions to Cookridge Hospital.

PMID- 29833419
TI  - On the Treatment of Pernicious Anaemia by Transfusion of Blood.

PMID- 29833420
TI  - English and American Doctors.

PMID- 29833421
TI  - Treatment of Pulmonary Phthisis-I.

PMID- 29833422
TI  - New Appliances and Things Medical.

PMID- 29833423
TI  - Sponges.

PMID- 29833424
TI  - The Sisters' Hospital, St. Alban's.

PMID- 29833426
TI  - The Care of the Feeble-Minded: I.-In Childhood.

PMID- 29833425
TI  - The Treatment of Tubercular Enteritis.

PMID- 29833427
TI  - Women's Work in South Africa.

PMID- 29833428
TI  - Annotations.

PMID- 29833429
TI  - Famous Poisoners in Fiction: IV. A Royal Poisoner.

PMID- 29833430
TI  - Gleanings in Science and Medicine.

PMID- 29833431
TI  - Analgen.

PMID- 29833432
TI  - Around the Hospitals.

PMID- 29833434
TI  - Notes and News.

PMID- 29833433
TI  - Diet in Disease: XXIX.-Chronic Bright's Disease.

PMID- 29833436
TI  - The Hospital Nursing Supplement.

PMID- 29833435
TI  - The Mystery of Influenza.

PMID- 29833437
TI  - Inunction in Scarlet Fever.

PMID- 29833438
TI  - New Appliances and Things Medical: New Preparations from the Sanitas Company.

PMID- 29833439
TI  - Construction Notes.

PMID- 29833440
TI  - The Treatment of Some Forms of Chronic Ulcer.

PMID- 29833441
TI  - Practical Experience in Poultice Making.

PMID- 29833442
TI  - New Appliances and Things Medical.

PMID- 29833444
TI  - Treatment of Glaucoma.

PMID- 29833443
TI  - Royal Victoria Hospital, Montreal.

PMID- 29833445
TI  - Notes and News.

PMID- 29833446
TI  - Annotations.-Experiment in Vaccination.

PMID- 29833447
TI  - The Hospital Nursing Supplement.

PMID- 29833448
TI  - Treatment of the Lateral Curvature of the Spine.

PMID- 29833449
TI  - Around the Hospitals.

PMID- 29833450
TI  - Construction Notes.

PMID- 29833451
TI  - King's College Hospital.

PMID- 29833452
TI  - Medical History from the Earliest Times: LXIV.-The Origin of Modern Medicine.

PMID- 29833453
TI  - Light, More Light.

PMID- 29833454
TI  - The Treatment of Pleurisy and Empyema.

PMID- 29833455
TI  - Contemporary Theory and Research.

PMID- 29833457
TI  - The "Pall Mall Gazette" and the London Hospital.

PMID- 29833456
TI  - Editor's Letter-Box.

PMID- 29833459
TI  - Annotations.

PMID- 29833458
TI  - Gleanings in Science and Medicine.

PMID- 29833461
TI  - Famous Poisoners in Fiction: V. The Poison Maid.

PMID- 29833460
TI  - Infantile Paralysis.

PMID- 29833462
TI  - Boot Warmer and Drier.

PMID- 29833463
TI  - Inunction in Scarlet Fever.

PMID- 29833464
TI  - The British Association.

PMID- 29833465
TI  - The Hospital Nursing Supplement.

PMID- 29833466
TI  - Special Hospitals: IV. Lying-In and Women.

PMID- 29833467
TI  - Fracture and Dislocation of the Spine.

PMID- 29833468
TI  - Notes and News.

PMID- 29833469
TI  - The Hygiene and Advantage of Illness.

PMID- 29833471
TI  - Contemporary Theory and Research.

PMID- 29833470
TI  - The Death at the London Hospital.

PMID- 29833472
TI  - Treatment of Ague.

PMID- 29833473
TI  - Construction Notes.

PMID- 29833475
TI  - Around the Hospitals.

PMID- 29833474
TI  - Gleanings in Science and Medicine.

PMID- 29833477
TI  - The Hospital Nursing Supplement.

PMID- 29833476
TI  - The Story of the Insane from Year to Year.

PMID- 29833479
TI  - Construction Notes.

PMID- 29833478
TI  - New Appliances and Things Medical: Oleusaban Disinfectants-Whole Wheat Flour with
      Hypophosphites.

PMID- 29833481
TI  - Great Achievements under Suffering: IV. The Blind Observer.

PMID- 29833480
TI  - Gleanings in Science and Medicine.

PMID- 29833482
TI  - How to Diminish the Numbers of Doctors.

PMID- 29833483
TI  - The Story of the Insane from Year to Year.

PMID- 29833484
TI  - Ingrowing Toe-Nail: I. Pathology.

PMID- 29833486
TI  - Around the Hospitals.

PMID- 29833485
TI  - The Student at the Apex.

PMID- 29833487
TI  - Annotations.

PMID- 29833488
TI  - Notes and News.

PMID- 29833489
TI  - Subcutaneous Injections of Strychnine.

PMID- 29833490
TI  - The History and Capabilities of Herbal Simples: The Gooseberry.

PMID- 29833491
TI  - Caries of the Spine.

PMID- 29833492
TI  - Famous Poisoners in Fiction: VI. A Mother's Love.

PMID- 29833493
TI  - In Later Life.

PMID- 29833494
TI  - Dressing Waggon.

PMID- 29833496
TI  - The Hospital Nursing Supplement.

PMID- 29833495
TI  - Special Hospitals: V. Ophthalmic and Miscellaneous-Cost of Management.

PMID- 29833497
TI  - Contemporary Theory and Research.

PMID- 29833499
TI  - The Treatment of Bronchitis.

PMID- 29833498
TI  - Chronic Intraventricular Effusion of Chronic Hydrocephalus.

PMID- 29833501
TI  - Famous Poisoners in Fiction: III. Catherine.

PMID- 29833500
TI  - Emergency Case.

PMID- 29833502
TI  - Temperature, Food, and Dress.

PMID- 29833503
TI  - Treatment of Cleft Palate.

PMID- 29833504
TI  - Wasps' Nurseries.

PMID- 29833505
TI  - Construction Notes.

PMID- 29833507
TI  - Hospitals in India: The Bengal Presidency-(2) Charitable Dispensaries under the
      Government of Bengal.

PMID- 29833506
TI  - The Attitude of Great Writers Towards Disease: Pepys on the Great Plague.

PMID- 29833508
TI  - Gleanings in Science and Medicine.

PMID- 29833509
TI  - Notes and News.

PMID- 29833510
TI  - Special Hospitals.

PMID- 29833511
TI  - Around the Hospitals.

PMID- 29833512
TI  - The London and Counties Medical Protection Society (Limited).

PMID- 29833513
TI  - Gas Stoves, &c.

PMID- 29833514
TI  - Annotations.

PMID- 29833515
TI  - Paddington Green Children's Hospital.

PMID- 29833517
TI  - Contemporary Theory and Research.

PMID- 29833516
TI  - Treatment of Club-Foot.

PMID- 29833518
TI  - The International Hospital Congress at Chicago.

PMID- 29833519
TI  - The Uses of Hospitals.

PMID- 29833520
TI  - The Methods and Applications of Skin Grafting.

PMID- 29833522
TI  - The Hospital Nursing Supplement.

PMID- 29833521
TI  - Diet in Disease: XXII.-Under-Feeding and Overeating.

PMID- 29833524
TI  - Notes and News.

PMID- 29833523
TI  - The London Hospital.-II.

PMID- 29833525
TI  - Medical History from the Earliest Times: LVII.-The Clinicians.

PMID- 29833526
TI  - Around the Hospitals.

PMID- 29833527
TI  - Annotations.

PMID- 29833528
TI  - Rhinoscopy: IV. Examination of the Nose.

PMID- 29833529
TI  - Gleanings in Science and Medicine.

PMID- 29833530
TI  - Construction Notes.

PMID- 29833531
TI  - How to Make Both Ends Meet: An Interview with the Rev. Canon Palmer.

PMID- 29833532
TI  - The London Hospital-I.

PMID- 29833533
TI  - The "Braloo" Window.

PMID- 29833534
TI  - The British Home for Incurables, Clapham.

PMID- 29833535
TI  - Hospital for Sick Children, Great Ormond Street.

PMID- 29833536
TI  - A Paternal Kingdom.

PMID- 29833537
TI  - Notes and News.

PMID- 29833538
TI  - Hospital Sweetness and Light.

PMID- 29833539
TI  - The Hospital Nursing Supplement.

PMID- 29833540
TI  - Around the Hospitals.

PMID- 29833542
TI  - Annotations.

PMID- 29833541
TI  - May the Children Help?

PMID- 29833543
TI  - Eucalyptus in the Treatment of Scarlet Fever by Inunction.

PMID- 29833544
TI  - Around the Hospitals.

PMID- 29833545
TI  - Should Adults Be Re Vaccinated?

PMID- 29833547
TI  - The Cost of the Royal Portsmouth Hospital, Portsmouth.

PMID- 29833546
TI  - Diet in Disease: XX.-Under-Feeding and Over-Eating.

PMID- 29833548
TI  - The Hospital Nursing Supplement.

PMID- 29833549
TI  - The Treatment of Asthma.

PMID- 29833550
TI  - King's College Hospital.

PMID- 29833551
TI  - Invalid Chairs.

PMID- 29833553
TI  - The Treatment of Rheumatism.

PMID- 29833552
TI  - Construction Notes.

PMID- 29833554
TI  - Gleanings in Science and Medicine.

PMID- 29833555
TI  - Notes and News.

PMID- 29833557
TI  - Contemporary Theory and Research.

PMID- 29833556
TI  - Medical History from the Earliest Times: LI.-The Reform of Surgery.

PMID- 29833559
TI  - Notes and News.

PMID- 29833558
TI  - Annotations.

PMID- 29833560
TI  - London Editors and London Hospitals.

PMID- 29833561
TI  - Famous Poisoners in Fiction: I.-Introductory.

PMID- 29833562
TI  - "Sanitas" Oil and Inunction.

PMID- 29833564
TI  - The London Hospital and the "Pall Mall Gazette".

PMID- 29833563
TI  - Diet in Disease: XXVII.-Ulcer of the Stomach.

PMID- 29833565
TI  - What Becomes of Stillborn Children?

PMID- 29833566
TI  - The Hospital Nursing Supplement.

PMID- 29833567
TI  - Around the Hospitals.

PMID- 29833568
TI  - The Treatment of Appendicitis.

PMID- 29833569
TI  - The Treatment of Pleurisy and Empyema.

PMID- 29833570
TI  - Gleanings in Science and Medicine.

PMID- 29833571
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29833572
TI  - Annotations.

PMID- 29833573
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29833575
TI  - Reading Stands.

PMID- 29833574
TI  - Antiseptic Treatment and Disinfection of Scarlet Fever: Remarks on the Method of
      Using Inunction.

PMID- 29833576
TI  - Convalescent Home for Charing Cross Hospital.

PMID- 29833577
TI  - Annotations.

PMID- 29833578
TI  - How to Keep Well in Africa: II. Cure.

PMID- 29833579
TI  - Huxley's Logic and Life.

PMID- 29833580
TI  - The Treatment of Gall-Stones at Leeds General Infirmary.

PMID- 29833581
TI  - Gleanings in Science and Medicine.

PMID- 29833582
TI  - Construction Notes.

PMID- 29833583
TI  - Treatment of His Simple Fracture of the Tibia and Fibula.

PMID- 29833584
TI  - New Appliances and Things Medical: Digestive Agents and Concentrated Food Stuffs.

PMID- 29833585
TI  - Medical History from the Earliest Times: LVI.-The Iatromechanical School.

PMID- 29833586
TI  - Notes and News.

PMID- 29833587
TI  - The Story of the Insane from Year to Year.

PMID- 29833588
TI  - The Hospital Nursing Supplement.

PMID- 29833589
TI  - Salophen.

PMID- 29833590
TI  - Contemporary Theory and Research.

PMID- 29833591
TI  - The Great Northern Central Hospital.

PMID- 29833592
TI  - Hospital for Women, Soho Square.

PMID- 29833593
TI  - What the Hospitals Do for the Public.

PMID- 29833595
TI  - Ward's Ambulance Trolly.

PMID- 29833594
TI  - Rhinoscopy: III. Examination of the Nose.

PMID- 29833597
TI  - The Claybury Asylum.

PMID- 29833596
TI  - The Hospitals of New York.

PMID- 29833598
TI  - The Treatment of Cosmetic Defects-II.

PMID- 29833600
TI  - Medical History from the Earliest Times: LIX.-The Animists.

PMID- 29833599
TI  - Chloralamide.

PMID- 29833601
TI  - The Hospital Nursing Supplement.

PMID- 29833602
TI  - Acromegale.

PMID- 29833603
TI  - Gleanings in Science and Medicine.

PMID- 29833604
TI  - The Royal British Nurses' Association.

PMID- 29833605
TI  - Annotations.

PMID- 29833606
TI  - North-Eastern Hospital for Children.

PMID- 29833608
TI  - Contemporary Theory and Research.

PMID- 29833607
TI  - The Treatment of Disinfection of Scarlet Fever by Antiseptic Inunction.

PMID- 29833609
TI  - New Appliances and Things Medical: Aminol-Elixir Picis Co.(Layne).

PMID- 29833610
TI  - Mr. Jonathan Hutchinson, F.R.S., on Doctors' Defences.

PMID- 29833611
TI  - Homes for Working Boys in London.

PMID- 29833613
TI  - Hospital Furniture.

PMID- 29833612
TI  - Diet in Disease: XXIV. Uric Acid as a Cause of Disease, and Its Prevention by
      Diet.

PMID- 29833614
TI  - Notes and News.

PMID- 29833615
TI  - Notes and News.

PMID- 29833616
TI  - Gleanings in Science and Medicine.

PMID- 29833617
TI  - The Opium Question.

PMID- 29833618
TI  - Warren's Cooking Pot.

PMID- 29833619
TI  - The Treatment of Intestinal Cancer.

PMID- 29833620
TI  - What Some of the Preachers Said.

PMID- 29833621
TI  - Foods for Arctic Explorers.

PMID- 29833623
TI  - The Treatment of Cosmetic Defects.-I.

PMID- 29833622
TI  - Annotations.

PMID- 29833624
TI  - New Appliances and Things Medical.

PMID- 29833625
TI  - The Disinfection of Wounds.

PMID- 29833626
TI  - Contemporary Theory and Research.

PMID- 29833628
TI  - The "Gourmet" Boiler.

PMID- 29833627
TI  - Diet in Disease: XXIII.-Food for the Aged.

PMID- 29833629
TI  - Medical History from the Earliest Times: LVIII.-The Clinicians.

PMID- 29833630
TI  - A Reminder for Absentees.

PMID- 29833631
TI  - The Morrell Mackenzie Controversy.

PMID- 29833632
TI  - The Hospital Nursing Supplement.

PMID- 29833634
TI  - The Hospital Nursing Supplement.

PMID- 29833633
TI  - Treatment of Otorrhoea.

PMID- 29833635
TI  - New Appliances and Things Medical: Dr. Langen's Sugar of Milk.

PMID- 29833636
TI  - Contemporary Theory and Research.

PMID- 29833637
TI  - Alumnol.

PMID- 29833638
TI  - Notes and News.

PMID- 29833639
TI  - Some Points in the Treatment of Scirrhus of the Breast.

PMID- 29833640
TI  - Bed Rest.

PMID- 29833641
TI  - Medical History from the Earliest Times: LV.-The Chemical School of Medicine.

PMID- 29833642
TI  - A Co-Operative Tour to Rome.

PMID- 29833643
TI  - On the Alleged Increase of Cancer.

PMID- 29833644
TI  - Rhinoscopy. II.

PMID- 29833645
TI  - Construction Notes.

PMID- 29833646
TI  - Bed Tables.

PMID- 29833647
TI  - Hospital for Epilepsy and Paralysis.

PMID- 29833648
TI  - The London Hospital.

PMID- 29833649
TI  - Royal Hospital for Children and Women.

PMID- 29833650
TI  - Diet in Disease: XXI.-Under-Feeding and Over-Eating.

PMID- 29833652
TI  - The German Hospital, Dalston.

PMID- 29833651
TI  - Some Neglected Medical Obligations.

PMID- 29833654
TI  - Annotations.

PMID- 29833653
TI  - The Charity Commissioners and the Lords Committee.

PMID- 29833656
TI  - Watford Cottage Hospital.

PMID- 29833655
TI  - Gleanings in Science and Medicine.

PMID- 29833658
TI  - Furniture for Nurses' Rooms.

PMID- 29833657
TI  - On a Form of Indigestion and Its Treatment.

PMID- 29833659
TI  - Treatment of Cancer of the Breast.

PMID- 29833660
TI  - Medical History from the Earliest Times: LXIII.-The Brunonian System.

PMID- 29833661
TI  - Notes and News.

PMID- 29833662
TI  - The History and Capabilities of Herbal Simples: Garlic and the Onion.

PMID- 29833663
TI  - Contemporary Theory and Research.

PMID- 29833664
TI  - Treatment of Stiff Joints.

PMID- 29833665
TI  - The Story of the Insane from Year to Year.

PMID- 29833666
TI  - New Appliances and Things Medical.

PMID- 29833667
TI  - Diet in Disease: XXVI.-On Thinning and Fattening.

PMID- 29833668
TI  - Annotations.

PMID- 29833669
TI  - Construction Notes.

PMID- 29833670
TI  - The Treatment of Cough as a Symptom in Phthisis.

PMID- 29833671
TI  - Guy's Hospital.

PMID- 29833672
TI  - Festival Dinners and Meetings.

PMID- 29833673
TI  - The Hospital Nursing Supplement.

PMID- 29833674
TI  - Around the Hospitals.

PMID- 29833675
TI  - Will Specialists Become Extinct?

PMID- 29833676
TI  - A New Order of General Practitioners.

PMID- 29833677
TI  - The Editor's Letter-Box.

PMID- 29833679
TI  - The Diagnosis and Treatment of Cystic Tumours in the Scalp.

PMID- 29833678
TI  - Ambulance Equipments.

PMID- 29833680
TI  - Construction Notes.

PMID- 29833681
TI  - Annotations.

PMID- 29833682
TI  - Around the Hospitals.

PMID- 29833683
TI  - Notes and News.

PMID- 29833685
TI  - General Hospitals.

PMID- 29833684
TI  - The History and Capabilities of Herbal Simples: Garlic and the Onion.

PMID- 29833687
TI  - Treatment of Compound Fractures.

PMID- 29833686
TI  - The Story of the Insane from Year to Year.

PMID- 29833689
TI  - Gleanings in Science and Medicine.

PMID- 29833688
TI  - Paraldehyde.

PMID- 29833691
TI  - The Hospital Nursing Supplement.

PMID- 29833690
TI  - Notes on the Treatment of Diabetes Mellitus.

PMID- 29833692
TI  - The Apotheosis of the Pawnbroker.

PMID- 29833693
TI  - Diet in Disease: XXVIII.-Chronic Bright's Disease.

PMID- 29833695
TI  - Hygienic Teapots.

PMID- 29833694
TI  - Construction Notes.

PMID- 29833696
TI  - Notes and News.

PMID- 29833697
TI  - The Present Position of Nursing.

PMID- 29833698
TI  - Contemporary Theory and Research.

PMID- 29833699
TI  - Around the Hospitals.

PMID- 29833701
TI  - St. Mary's Hospital.

PMID- 29833700
TI  - The Hospital Nursing Supplement.

PMID- 29833702
TI  - Treatment of Pulmonary Phthisis.

PMID- 29833703
TI  - Our Weaker Brethren.

PMID- 29833704
TI  - Gleanings in Science and Medicine.

PMID- 29833705
TI  - Annotations.

PMID- 29833706
TI  - Some Simple Uses of Carbolic Acid.

PMID- 29833707
TI  - Medical History from the Earliest Times: LXI.-The Organicists.

PMID- 29833708
TI  - Antiseptic Inunction in Scarlet Fever.

PMID- 29833709
TI  - Arrangement for Electrical Treatment.

PMID- 29833710
TI  - Toilet Tray.

PMID- 29833711
TI  - The Illinois Training School for Nurses.

PMID- 29833712
TI  - Earlswood Asylum.

PMID- 29833713
TI  - Notes and News.

PMID- 29833714
TI  - The Nurture of Royal Infants.

PMID- 29833716
TI  - Epilepsy and Paralysis.

PMID- 29833715
TI  - Miss Ethel M. Warner and Mr. Lawson Tait.

PMID- 29833717
TI  - Women.

PMID- 29833718
TI  - Miscellaneous Special.

PMID- 29833719
TI  - Lying-In.

PMID- 29833720
TI  - Children.

PMID- 29833721
TI  - General Hospitals.

PMID- 29833722
TI  - The Doctor's Christmas.

PMID- 29833724
TI  - Consumption.

PMID- 29833723
TI  - Our Christmas Tableaux Vivants.

PMID- 29833725
TI  - The Christmas Numbers.

PMID- 29833726
TI  - The Out-Patient.

PMID- 29833727
TI  - St. Mary's Hospital, Paddington: The Clarence Memorial Wing.

PMID- 29833728
TI  - Christmas Thoughts at the National Gallery.

PMID- 29833729
TI  - Oxford at Its Best.

PMID- 29833730
TI  - One Merry Christmas Bell.

PMID- 29833731
TI  - The Hospital Nursing Supplement.

PMID- 29833733
TI  - A Few Other Charities.

PMID- 29833732
TI  - Where to Send Christmas Boxes.

PMID- 29833734
TI  - A Nursing Centre for the Empire.

PMID- 29833735
TI  - Laying the Foundation-Stone.

PMID- 29833737
TI  - Clearing-House for Unmarried Mothers.

PMID- 29833736
TI  - Statistical Report on Expenditure of London Hospitals.

PMID- 29833738
TI  - Control of Parenthood.

PMID- 29833739
TI  - Secret Remedies of the Past.

PMID- 29833740
TI  - The National Council of Women.

PMID- 29833741
TI  - The New Call for Visiting Nurses.

PMID- 29833743
TI  - A Pioneer Scheme.

PMID- 29833742
TI  - Tuberculosis in Jugo-Slavia.

PMID- 29833745
TI  - Important Meeting of Pharmacists.

PMID- 29833744
TI  - A Colony for Defectives.

PMID- 29833747
TI  - The New Abertillery and District Hospital.

PMID- 29833746
TI  - Is It Possible?

PMID- 29833749
TI  - Then and Now.

PMID- 29833748
TI  - Salaries of Health Visitors and Sanitary Inspectors.

PMID- 29833751
TI  - The Red Cross Market.

PMID- 29833750
TI  - The Australasian Medical Congress.

PMID- 29833752
TI  - The Cost of the Unit.

PMID- 29833753
TI  - General Nursing Council Decides against Publicity.

PMID- 29833755
TI  - Round the Hospitals.

PMID- 29833754
TI  - Death and the Doctors.

PMID- 29833756
TI  - An Advisory and Treatment Centre.

PMID- 29833757
TI  - Hospital and Institutional News.

PMID- 29833758
TI  - A Grateful Patient.

PMID- 29833759
TI  - Strike's Effect on Health.

PMID- 29833760
TI  - Sir George Newman on the Ministry of Health's Position.

PMID- 29833761
TI  - Some Notes from a Personal Experience.

PMID- 29833762
TI  - A "Gunpowder Plot".

PMID- 29833763
TI  - Meeting at the Mansion House.

PMID- 29833764
TI  - Hospital and Institutional News.

PMID- 29833765
TI  - An Atlas of the Cutaneous Nerves.

PMID- 29833766
TI  - In Theory and in Practice.

PMID- 29833767
TI  - The South Shields Sanatorium.

PMID- 29833768
TI  - London's New Club.

PMID- 29833769
TI  - The Foes of Hospital Economy.

PMID- 29833771
TI  - Income Tax on "Profits" of Charities.

PMID- 29833770
TI  - Central Council for District Nursing in London.

PMID- 29833772
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29833773
TI  - The Hospital Crisis Once More.

PMID- 29833774
TI  - The Way to Industrial Health.

PMID- 29833775
TI  - Hospital Pharmacists as Examiners.

PMID- 29833776
TI  - Cheap Medicine for All.

PMID- 29833777
TI  - Private Nurses and the College.

PMID- 29833778
TI  - The Best School Discipline.

PMID- 29833779
TI  - The Schools of Anatomy.

PMID- 29833780
TI  - Plague and the Rat.

PMID- 29833782
TI  - Round the Hospitals.

PMID- 29833781
TI  - The Association of Certificated Blind Masseurs.

PMID- 29833783
TI  - The Royal Medical Benevolent Fund Guild.

PMID- 29833784
TI  - The Position of Women at Cambridge.

PMID- 29833785
TI  - As Depicted by Engraved Views.-I.

PMID- 29833786
TI  - Nurses and the Unemployment Act.

PMID- 29833787
TI  - Verbatim Report of the Extraordinary General Meeting.

PMID- 29833788
TI  - Two Kinds of Health.

PMID- 29833789
TI  - Passing Events and Topics.

PMID- 29833791
TI  - Meeting of the East Midlands District Regional Committee.

PMID- 29833790
TI  - Are Nurses Necessary?

PMID- 29833792
TI  - Unnecessary Noise.

PMID- 29833793
TI  - Some Cars for Professional Men.

PMID- 29833794
TI  - The New Ideals of District Nursing.

PMID- 29833795
TI  - An Old Comrades' Guild.

PMID- 29833796
TI  - Nursing Problems and Their Solution.

PMID- 29833797
TI  - Mixed Views on Alcohol.

PMID- 29833798
TI  - Married Health Visitors.

PMID- 29833799
TI  - The Gift of Expression.

PMID- 29833800
TI  - Women and Public Health.

PMID- 29833801
TI  - Some Records from Insurance Practice.

PMID- 29833802
TI  - Patients' Payments.

PMID- 29833803
TI  - Concerning Propaganda.

PMID- 29833804
TI  - The Foundress of St. Columba's.

PMID- 29833805
TI  - Hospital Problems in India.

PMID- 29833806
TI  - State Registration and Its Values.

PMID- 29833807
TI  - The Minimum Age for Training.

PMID- 29833808
TI  - What Is Sleep?

PMID- 29833809
TI  - Model Milk.

PMID- 29833810
TI  - The Cumberland Infirmary Inquiry.

PMID- 29833811
TI  - The Spread of Venereal Disease.

PMID- 29833812
TI  - Round the Hospitals.

PMID- 29833813
TI  - Sir Napier Burnett's Confidential Report.

PMID- 29833815
TI  - Hospital and Institutional News.

PMID- 29833814
TI  - Concerning Clothes.

PMID- 29833816
TI  - "Safety First" Campaign.

PMID- 29833817
TI  - Round the Hospitals.

PMID- 29833818
TI  - A New Era for Poor-Law Nurses.

PMID- 29833819
TI  - The Editor's Letter-Box.

PMID- 29833821
TI  - A "Barrage" against Disease.

PMID- 29833820
TI  - Radiant Motherhood.

PMID- 29833822
TI  - The College of Nursing. (Limited by Guarantee).

PMID- 29833823
TI  - The Bournville Productions.

PMID- 29833825
TI  - Noise and Health.

PMID- 29833824
TI  - Welfare Workers in Industry.

PMID- 29833826
TI  - Harley Street Associations.

PMID- 29833827
TI  - How Long Halt Ye?

PMID- 29833828
TI  - Conference to Form a London Region.

PMID- 29833829
TI  - The Uses of Advertisement.

PMID- 29833830
TI  - The Editor's Letter-Box.

PMID- 29833831
TI  - A Common Symptom Complex Explained.

PMID- 29833832
TI  - The Earliest European Hospital.

PMID- 29833834
TI  - The Resilience of Hospital Finance.

PMID- 29833833
TI  - The London Regional Committee.

PMID- 29833835
TI  - Public Pharmacists' Association.

PMID- 29833836
TI  - Official Report of the Financial Position.

PMID- 29833838
TI  - Hospital and Institutional News.

PMID- 29833837
TI  - The Fight against Tuberculosis.

PMID- 29833839
TI  - A Medical Service for All.

PMID- 29833840
TI  - A Friend of Many Years.

PMID- 29833841
TI  - Mental Treatment for Crime.

PMID- 29833842
TI  - The Economic Development of the Nursing Services.

PMID- 29833843
TI  - Cumberland Infirmary.

PMID- 29833844
TI  - The General Nursing Council for Scotland.

PMID- 29833845
TI  - The Surgery of the "Crusades".

PMID- 29833846
TI  - The Future of Orthopaedic Surgery.

PMID- 29833847
TI  - Hospital and Institutional News.

PMID- 29833849
TI  - Grants to Medical Schools of London.

PMID- 29833848
TI  - Report of the Distribution Committee.

PMID- 29833850
TI  - New Ways of Dealing with an Old Problem.

PMID- 29833851
TI  - Hours of Employment: Council's Answer to Labour Minister.

PMID- 29833852
TI  - Housing the Nursing Staff.

PMID- 29833853
TI  - The Living-Out System.

PMID- 29833854
TI  - Cross-Currents in the General Nursing Council.

PMID- 29833855
TI  - Substantial Annual Distribution.

PMID- 29833856
TI  - A Guide to Christmas Benefactors.

PMID- 29833857
TI  - Placing the Responsibility.

PMID- 29833858
TI  - A Christmas Opportunity.

PMID- 29833859
TI  - Tuberculosis Notes.

PMID- 29833860
TI  - National "Unfits".

PMID- 29833861
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29833862
TI  - How Long Halt Ye?

PMID- 29833863
TI  - How Many Hospital Beds Are Required to Train a Nurse?

PMID- 29833864
TI  - Round the Hospitals.

PMID- 29833865
TI  - Anticipation and Realisation.

PMID- 29833866
TI  - As Depicted by Engraved Views.-III.

PMID- 29833867
TI  - Nurses' Work for the Poor.

PMID- 29833868
TI  - Dental Treatment in Schools.

PMID- 29833870
TI  - The Ministry of Health.

PMID- 29833869
TI  - The Territorial Force Nursing Service.

PMID- 29833872
TI  - The Dangerous Drugs Act Regulations.

PMID- 29833871
TI  - Some Curious Fashions, Old and New.

PMID- 29833874
TI  - Sanatorium Treatment of Tuberculosis.

PMID- 29833873
TI  - What the Local Centres Are Doing.

PMID- 29833876
TI  - The Coming College Elections.

PMID- 29833875
TI  - Passing Events and Topics.

PMID- 29833877
TI  - Round the Hospitals.

PMID- 29833878
TI  - The Middle-Aged Man.

PMID- 29833879
TI  - Hospital and Institutional News.

PMID- 29833880
TI  - Who Will Voice the Nurse?

PMID- 29833881
TI  - Opinions Urgently Needed.

PMID- 29833882
TI  - The Salaries of Fever Nurses.

PMID- 29833883
TI  - Municipal Representation on Hospital Committees.

PMID- 29833884
TI  - News from South Africa.

PMID- 29833885
TI  - Future of Poor-Law Infirmaries.

PMID- 29833886
TI  - Midwifery in 1919-1920.

PMID- 29833887
TI  - Achievements of the past and Hopes for the Future.

PMID- 29833888
TI  - The Localisation of Haemoptysis.

PMID- 29833890
TI  - With Special Reference to the Children of To-Day.

PMID- 29833889
TI  - Small-Holdings and Hospitals.

PMID- 29833891
TI  - The Physical Factor in Emigration.

PMID- 29833892
TI  - The Committee on Voluntary Hospitals.

PMID- 29833893
TI  - Housing and Health.

PMID- 29833894
TI  - Sleeping Sickness.

PMID- 29833895
TI  - The General and Medical Work of a Deserving Mission.

PMID- 29833896
TI  - Lady Cowdray's Great Ideal.

PMID- 29833898
TI  - The Nineteen-Year-Old Probationer.

PMID- 29833897
TI  - Dr. Gordon Dill's Provident Scheme.

PMID- 29833899
TI  - Furthermore Concerning Propaganda.

PMID- 29833900
TI  - Women Doctors.

PMID- 29833901
TI  - Complement Fixation.

PMID- 29833902
TI  - American Help for Child Welfare.

PMID- 29833903
TI  - Problems of Venereal Disease.

PMID- 29833904
TI  - State Control in Recruiting Probationers.

PMID- 29833905
TI  - Chartered Society of Massage and Remedial Gymnastics.

PMID- 29833906
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29833907
TI  - The Dignity of Life.

PMID- 29833908
TI  - Impressions of a Visit.

PMID- 29833909
TI  - Round the Hospitals.

PMID- 29833910
TI  - Dust on the Underground.

PMID- 29833911
TI  - A Review of the Present Position.

PMID- 29833912
TI  - Everybody's Day.

PMID- 29833914
TI  - Hospital and Institutional News.

PMID- 29833913
TI  - The Gift of Expression.

PMID- 29833915
TI  - The Right to Motherhood.

PMID- 29833916
TI  - Passing Events and Topics.

PMID- 29833917
TI  - The Middlesex Training School.

PMID- 29833918
TI  - An X-Rays Laboratory.

PMID- 29833920
TI  - The Liking for Hospitals.

PMID- 29833919
TI  - Pathological Research.

PMID- 29833921
TI  - Our Medical Schools' Reopening.

PMID- 29833922
TI  - Advertising for Probationers.

PMID- 29833923
TI  - Hospital Gazettes and Journals.

PMID- 29833924
TI  - A Public Health Fund.

PMID- 29833925
TI  - Amalgamation at Weymouth.

PMID- 29833926
TI  - Agricultural Subscribers.

PMID- 29833928
TI  - Working Women and Maternity.

PMID- 29833927
TI  - Payments by Patients.

PMID- 29833929
TI  - Health and Artistry.

PMID- 29833930
TI  - Subscriptions from Members of the College.

PMID- 29833931
TI  - Advice from the Health Ministry.

PMID- 29833932
TI  - A Son of Life, and Other Poems.

PMID- 29833933
TI  - Round the Hospitals.

PMID- 29833934
TI  - Team Work among Nurses.

PMID- 29833936
TI  - Hospital and Institutional News.

PMID- 29833935
TI  - Rest and Recreation.

PMID- 29833937
TI  - Progress of the Principle of Patients' Payments.

PMID- 29833938
TI  - Tuberculosis Heresies?

PMID- 29833939
TI  - Dietary Scale in a Poor-Law Infirmary.

PMID- 29833940
TI  - The General Practitioner.

PMID- 29833941
TI  - Red Cross Conference in Cardiff.

PMID- 29833942
TI  - The Conservation of Motherhood.

PMID- 29833943
TI  - What It Might Achieve.

PMID- 29833944
TI  - Contributed by One of Them.

PMID- 29833945
TI  - Schools and London Hospitals.

PMID- 29833946
TI  - Hospital Problems in India.

PMID- 29833947
TI  - New Licensing Rules of the L.C.C.

PMID- 29833948
TI  - The New Hospital in Shillong, Assam.

PMID- 29833949
TI  - Death from Starvation.

PMID- 29833951
TI  - Unemployment Insurance.

PMID- 29833950
TI  - Suggestion as an Aid in Nursing.

PMID- 29833952
TI  - Crime Films.

PMID- 29833953
TI  - Report of the Convalescent Homes Committee.

PMID- 29833955
TI  - A Medical Service for All.

PMID- 29833954
TI  - Report of the Distribution Committee.

PMID- 29833957
TI  - A Christmas Appeal.

PMID- 29833956
TI  - Child Welfare and Nutrition.

PMID- 29833959
TI  - The Fellowship of Christmas.

PMID- 29833958
TI  - The New Scheme of the Hospital Officers' Association.

PMID- 29833960
TI  - An Open Letter to Private Nurses.

PMID- 29833961
TI  - A Century of Technical Publishing.

PMID- 29833962
TI  - The City of London (Chest) Hospital.

PMID- 29833963
TI  - Hospital and Institutional News.

PMID- 29833964
TI  - On Agitation.

PMID- 29833965
TI  - The Sick and Wounded.

PMID- 29833966
TI  - Hospitals as Training Centres for Nurses.

PMID- 29833967
TI  - Round the Hospitals.

PMID- 29833968
TI  - The Rejected Bill.

PMID- 29833969
TI  - A Historical Sketch and Some Aspects of Sterility.

PMID- 29833970
TI  - The Living-Out System.

PMID- 29833971
TI  - The Festival of Healing.

PMID- 29833972
TI  - The League of Mercy and the Red Cross.

PMID- 29833973
TI  - Women and a New World.

PMID- 29833974
TI  - Why It Appeals to Me.

PMID- 29833975
TI  - Parliament and the Professions.

PMID- 29833976
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29833977
TI  - Juvenile Delinquents.

PMID- 29833978
TI  - Housing the Nursing Staff.

PMID- 29833979
TI  - An Invention to Improve Both Efficiency and Economy.

PMID- 29833980
TI  - Conference to Consider State or Rate Hospital Question.

PMID- 29833982
TI  - The Great Northern Appeal.

PMID- 29833981
TI  - Round the Hospitals.

PMID- 29833983
TI  - An Echo of the Nineteenth Century.

PMID- 29833984
TI  - A Central Test for Candidates.

PMID- 29833985
TI  - Healthier Factories.

PMID- 29833986
TI  - War on Disease.

PMID- 29833987
TI  - The Child's Psychology.

PMID- 29833988
TI  - A Memorable Home-Coming.

PMID- 29833990
TI  - The Fruits of the Harvest.

PMID- 29833989
TI  - An International Medical Degree.

PMID- 29833991
TI  - Children and the Cinema.

PMID- 29833992
TI  - The Future of the Poor-Law Hospital.

PMID- 29833993
TI  - The Eight-Hour Day-Myth or Reality.

PMID- 29833994
TI  - Our War Nurses.

PMID- 29833995
TI  - The Opening Events of the New Session.

PMID- 29833996
TI  - Tuberculosis.

PMID- 29833997
TI  - Their Keeping Properties.

PMID- 29833998
TI  - Some Noticeable Features.

PMID- 29833999
TI  - A Volume of Smoke and Very Little Fire.

PMID- 29834000
TI  - The End of the Prince of Wales' Tour.

PMID- 29834001
TI  - The Gift of Expression.

PMID- 29834003
TI  - Some Comments on the Methods of To-Day.

PMID- 29834002
TI  - The College Studentships.

PMID- 29834005
TI  - Is the Rising Birth-Rate a Blessing?

PMID- 29834004
TI  - Some Questions to Sir Napier Burnett.

PMID- 29834007
TI  - The Dangerous Drugs Act 1920 and Hospitals.

PMID- 29834006
TI  - Hospital and Institutional News.

PMID- 29834009
TI  - The Editor's Letter-Box.

PMID- 29834008
TI  - A Real Pioneer.

PMID- 29834011
TI  - The Press and the Nursing Council.

PMID- 29834010
TI  - Warwickshire's Record.

PMID- 29834012
TI  - Australian Notes.

PMID- 29834013
TI  - The Guild of St. Thomas.

PMID- 29834014
TI  - A Stores Superintendent's Views.

PMID- 29834015
TI  - The Fever Epidemic.

PMID- 29834016
TI  - Private Nursing under a State Service.

PMID- 29834017
TI  - The Hospitals' Future in the Balance.

PMID- 29834019
TI  - A Review, and a Forecast.

PMID- 29834018
TI  - Nursing at the London Hospital.

PMID- 29834021
TI  - The Importance of Breast-Feeding.

PMID- 29834020
TI  - The Editor's Letter-Box.

PMID- 29834022
TI  - The Position of Women at Cambridge.

PMID- 29834023
TI  - The Financial Side.

PMID- 29834024
TI  - Tuberculosis Topics.

PMID- 29834025
TI  - A Little Shock for Tobacco Smokers.

PMID- 29834027
TI  - The Views and Aims o the Hospital Almoners' Council.

PMID- 29834026
TI  - Dr. Marie Stopes' Utopia.

PMID- 29834029
TI  - Cardiff Mental Hospital.

PMID- 29834028
TI  - American Women and Birth Control.

PMID- 29834031
TI  - The College Election Puzzle.

PMID- 29834030
TI  - Public Pharmacists' Association.

PMID- 29834032
TI  - Round the Hospitals.

PMID- 29834033
TI  - Infant Mortality in Europe.

PMID- 29834034
TI  - Hospital and Institutional News.

PMID- 29834035
TI  - Trade Subscriptions.

PMID- 29834036
TI  - Nursing Hours and Nursing Institutions.

PMID- 29834037
TI  - Twenty-First Annual Meeting of Presidents.

PMID- 29834038
TI  - Liverpool and Venereal Disease.

PMID- 29834039
TI  - Experimental Nursery Schools.

PMID- 29834040
TI  - Grants to Foster-Mothers.

PMID- 29834041
TI  - A Policy for the New Year.

PMID- 29834042
TI  - Hours and State Control.

PMID- 29834043
TI  - Will There Be Two Grades of Nurses?

PMID- 29834044
TI  - The Editor's Letter-Box.

PMID- 29834045
TI  - Round the Hospitals.

PMID- 29834046
TI  - Hospital and Institutional News.

PMID- 29834047
TI  - The Dowager Lady Roberts.

PMID- 29834048
TI  - How Long Halt Ye?

PMID- 29834050
TI  - Its Uses and Technique.

PMID- 29834049
TI  - Physical Training in Continuation Schools.

PMID- 29834051
TI  - Housing the Nursing Staffs.

PMID- 29834052
TI  - The Hospitals' Christmas.

PMID- 29834053
TI  - The Editor's Letter-Box.

PMID- 29834055
TI  - The Physique of School Teachers.

PMID- 29834054
TI  - Wills of Medical Men.

PMID- 29834056
TI  - The Plight of the Scottish Jubilee Institute.

PMID- 29834057
TI  - Prescription Writing.

PMID- 29834058
TI  - The Medical Standpoint.

PMID- 29834059
TI  - The Nurses' Co-Operation.

PMID- 29834060
TI  - Hospital and Institutional News.

PMID- 29834061
TI  - Nurse-Teachers for Invalid Children.

PMID- 29834062
TI  - Scotch Doctors and the Voluntary System.

PMID- 29834063
TI  - Incipient Mental Diseases.

PMID- 29834064
TI  - Workhouse Waste.

PMID- 29834065
TI  - How Long Halt Ye?

PMID- 29834066
TI  - The System of Living-In.

PMID- 29834067
TI  - London County Council and Tuberculosis Dispensaries.

PMID- 29834068
TI  - Books for Sick Men.

PMID- 29834069
TI  - Sickness and the New Poor.

PMID- 29834070
TI  - Uniform Scale of Salaries in Poor-Law Infirmaries.

PMID- 29834071
TI  - Women in Factories.

PMID- 29834072
TI  - The College of Nursing and Affiliated Training Schools.

PMID- 29834073
TI  - As Depicted by Engraved Views.-II.

PMID- 29834074
TI  - The Medical Future.

PMID- 29834075
TI  - Round the Hospitals.

PMID- 29834076
TI  - The Unchampioned Nurse.

PMID- 29834078
TI  - Nurses' Needlework Guild.

PMID- 29834077
TI  - The Unmarried Mother and Her Child.

PMID- 29834080
TI  - The Diagnosis and Treatment of Tuberculous Infections.

PMID- 29834079
TI  - Surgical Treatment of Sub-Acute Nephritis.

PMID- 29834081
TI  - The Royal Institute of Public Health.

PMID- 29834082
TI  - The Position of Women at Cambridge.

PMID- 29834083
TI  - Holiday Camp Schools.

PMID- 29834084
TI  - The Nurses' Co-Operation.

PMID- 29834085
TI  - Some Problems and Our Steps to Solve Them.

PMID- 29834086
TI  - University Diplomas in Nursing.

PMID- 29834088
TI  - Discussion by the Harveian Society.

PMID- 29834087
TI  - Midwives (Scotland) Act, 1915.

PMID- 29834089
TI  - Brown and White Sugars.

PMID- 29834090
TI  - The Piper Calls the Tune.

PMID- 29834092
TI  - Post-Graduate Education in London.

PMID- 29834091
TI  - Mr. James Sutherland.

PMID- 29834093
TI  - Problems of Sanitation.

PMID- 29834094
TI  - The Utility Bed.

PMID- 29834095
TI  - A Gruesome Controversy.

PMID- 29834096
TI  - Physical Tests for School Children.

PMID- 29834098
TI  - Obtaining Relief by False Pretences.

PMID- 29834097
TI  - Scottish Local Authorities and Sanatorium Treatment.

PMID- 29834099
TI  - An Emblem of Decay.

PMID- 29834100
TI  - The Manifesto of the Voluntary System.

PMID- 29834102
TI  - Army Schools of Hygiene.

PMID- 29834101
TI  - Hospital and Institutional News.

PMID- 29834103
TI  - Policy of King Edward's Hospital Fund.

PMID- 29834104
TI  - The Resolutions Adopted.

PMID- 29834105
TI  - Birth-Rates and World Wars.

PMID- 29834106
TI  - Private Hospitals.

PMID- 29834108
TI  - The Society of Radiographers.

PMID- 29834107
TI  - The Best Form of Medical Service.

PMID- 29834109
TI  - British Hospitals Association: Scottish Regional Committee.

PMID- 29834110
TI  - Round the Hospitals.

PMID- 29834111
TI  - The College Very Much Alive.

PMID- 29834112
TI  - Fighting Disease by Propaganda.

PMID- 29834113
TI  - Civic League Lectures.

PMID- 29834114
TI  - In a Budapesth Hospital.

PMID- 29834115
TI  - King Edward's Hospital Fund for London.

PMID- 29834116
TI  - Words and Deeds.

PMID- 29834117
TI  - Teachers in Conference.

PMID- 29834118
TI  - The London County Westminster and Parr's Bank Ltd.

PMID- 29834119
TI  - The College Scale of Minimum Salaries.

PMID- 29834121
TI  - Intra-Abdominal Adhesions.

PMID- 29834120
TI  - Psycho-Analysis and Other Fashions.

PMID- 29834122
TI  - Monsters.

PMID- 29834123
TI  - Spinal Anaesthesia.

PMID- 29834125
TI  - As Depicted by Engraved Views.-IV.

PMID- 29834124
TI  - Should Medical Practitioners Dispense Medicines?

PMID- 29834126
TI  - "Wasting" Money in Public Health.

PMID- 29834127
TI  - Passing Events and Topics.

PMID- 29834128
TI  - Please Keep Step.

PMID- 29834129
TI  - Unemployed and Unemployables.

PMID- 29834130
TI  - Will College Members Please Note.

PMID- 29834131
TI  - Birth-Rate Factors.

PMID- 29834132
TI  - How Long Halt Ye?

PMID- 29834133
TI  - The Protest against Unemployment Insurance.

PMID- 29834134
TI  - Round the Hospitals.

PMID- 29834135
TI  - Hospital and Institutional News.

PMID- 29834136
TI  - Education in Army Hospitals.

PMID- 29834138
TI  - Brawn or Brains-Or Both?

PMID- 29834137
TI  - Hospital Problems in India.

PMID- 29834139
TI  - Anti-Typhus Appeal.

PMID- 29834140
TI  - What "Panel-Prying" Really Is.

PMID- 29834141
TI  - The Suggested Scale of Miniumum Salaries.

PMID- 29834142
TI  - The Dean of St. Paul's on Eugenics.

PMID- 29834143
TI  - The Care of Cripples.

PMID- 29834144
TI  - New Subscription Scheme Confirmed.

PMID- 29834145
TI  - Morality and Marriage.

PMID- 29834146
TI  - Ministry of Health or Ministry of Labour.

PMID- 29834147
TI  - The American Society in London.

PMID- 29834148
TI  - Two Chairmen on the Crisis.

PMID- 29834150
TI  - Incrustations in Soil-Pipes.

PMID- 29834149
TI  - The Anti-Tuberculosis Campaign.

PMID- 29834151
TI  - Nursing the Baby.

PMID- 29834152
TI  - Open-Air Schools.

PMID- 29834154
TI  - Old Age and Death.

PMID- 29834153
TI  - The Future of the Hospitals.

PMID- 29834155
TI  - A Position They Soon Must Hold.

PMID- 29834156
TI  - Resettlement in New Zealand.

PMID- 29834158
TI  - Passing Events and Topics.

PMID- 29834157
TI  - How Long Halt Ye?

PMID- 29834159
TI  - Parliament and the Professions.

PMID- 29834160
TI  - Round the Hospitals.

PMID- 29834161
TI  - The Essential Function of the Health Visitor.

PMID- 29834162
TI  - Is the College Too Young?

PMID- 29834163
TI  - The Foes of Hospital Economy.

PMID- 29834165
TI  - A Strong Policy Outlined.

PMID- 29834164
TI  - Scotland's Record Marriage Figures.

PMID- 29834167
TI  - Report of Nine Months' Work.

PMID- 29834166
TI  - How It Concerns Nurses.

PMID- 29834168
TI  - Hospital and Institutional News.

PMID- 29834169
TI  - A Dividing Line Impossible?

PMID- 29834170
TI  - The Case of Morphine Poisoning.

PMID- 29834171
TI  - More about the Cowdray Gifts.

PMID- 29834172
TI  - Service and Self-Surrender.

PMID- 29834173
TI  - Words and Deeds.

PMID- 29834174
TI  - Heresy or Truth?

PMID- 29834175
TI  - The Secrets of the Panel.

PMID- 29834176
TI  - A Strange Isolation Hospital.

PMID- 29834177
TI  - Tuberculosis Notes.

PMID- 29834178
TI  - The Prognosis in Renal Cases.

PMID- 29834179
TI  - Private Nursing Fees.

PMID- 29834180
TI  - What Is the Truth about Bradford?

PMID- 29834181
TI  - Entire State Control.

PMID- 29834182
TI  - Provision of Hospital Accommodation.

PMID- 29834183
TI  - Hospital and Institutional News.

PMID- 29834184
TI  - New Sanatoria.

PMID- 29834185
TI  - The Best Form of Medical Service.

PMID- 29834186
TI  - Should Public Health Services Be Scrapped?

PMID- 29834187
TI  - The Year-Book of Charity.

PMID- 29834188
TI  - Women Jurors.

PMID- 29834189
TI  - Nursing at the Royal Infirmary of Edinburgh.

PMID- 29834190
TI  - Importance of the 1921 Census.

PMID- 29834191
TI  - General Nursing Council for Scotland.

PMID- 29834192
TI  - The State Doctor and the Home.

PMID- 29834194
TI  - A Year of Progress and Financial Prosperity.

PMID- 29834193
TI  - The Coventry Programme.

PMID- 29834195
TI  - Round the Hospitals.

PMID- 29834196
TI  - How Long Halt Ye?

PMID- 29834198
TI  - The Dawn of the Professional Spirit.

PMID- 29834197
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29834200
TI  - The Labour Ministry and Unemployment Insurance.

PMID- 29834199
TI  - Co-Operation or Chaos?

PMID- 29834201
TI  - Private Nurses and the Hours of Employment Bill.

PMID- 29834202
TI  - The Medical Research Council's Annual Report.

PMID- 29834203
TI  - Doctor and Patient.

PMID- 29834205
TI  - Passing Events and Topics.

PMID- 29834204
TI  - Massage and Medical Gymnastics.

PMID- 29834206
TI  - "Propaganda" Films and Censorship.

PMID- 29834207
TI  - The Hospitals' Christmas.

PMID- 29834208
TI  - Hospital and Institutional News.

PMID- 29834209
TI  - First Meeting of the London Regional Committee.

PMID- 29834211
TI  - Alterations in the Poison Schedule under the Poisons and Pharmacy Act.

PMID- 29834210
TI  - The Discussion of a Policy.

PMID- 29834213
TI  - How Old Is a Man at Forty?

PMID- 29834212
TI  - Round the Hospitals.

PMID- 29834215
TI  - Eugenics in the School.

PMID- 29834214
TI  - The Nurse and Her Advocates.

PMID- 29834217
TI  - How Beds Are Endowed at Leicester.

PMID- 29834216
TI  - The Registrar-General's Figures.

PMID- 29834218
TI  - Cleanliness by Law.

PMID- 29834219
TI  - Nursing in the Bethlem Royal Hospital.

PMID- 29834220
TI  - How to Use the New Journalism.

PMID- 29834221
TI  - Venereal Disease Problems.

PMID- 29834222
TI  - Children's Hospital, Birmingham.

PMID- 29834223
TI  - New Sanatoria.

PMID- 29834225
TI  - An Unsentimental Appeal.

PMID- 29834224
TI  - Public Pharmacists' Association.

PMID- 29834227
TI  - Hospital and Institutional News.

PMID- 29834226
TI  - Fair and Dark.

PMID- 29834229
TI  - Defects in London Methods.

PMID- 29834228
TI  - Nurses and Trade Unions.

PMID- 29834231
TI  - Paying Patients and Doctors' Fees.

PMID- 29834230
TI  - Provision of Hospital Accommodation.

PMID- 29834233
TI  - Passing Events and Topics.

PMID- 29834232
TI  - Round the Hospitals.

PMID- 29834234
TI  - Many Important Matters Decided.

PMID- 29834235
TI  - Is Fatigue a Disease?

PMID- 29834236
TI  - The New Basis of Nursing Education.

PMID- 29834237
TI  - Voluntary Hospitals.

PMID- 29834238
TI  - Those Record Cards.

PMID- 29834239
TI  - A Disquieting Document.

PMID- 29834240
TI  - Hospital Employees and Unemployment Insurance.

PMID- 29834241
TI  - The New System of Paying Patients.

PMID- 29834242
TI  - The Doubtful Case of Diphtheria.

PMID- 29834243
TI  - Reform of the Poor Law.

PMID- 29834244
TI  - The Importance of Nursery Schools.

PMID- 29834245
TI  - Sunday Games.

PMID- 29834246
TI  - More about Private Hospitals.

PMID- 29834247
TI  - Its History and Development: The Missions' Share.

PMID- 29834248
TI  - Public Education.

PMID- 29834249
TI  - The Best Form of Medical Service.

PMID- 29834251
TI  - Round the Hospitals.

PMID- 29834250
TI  - Caveats for Dispensers.

PMID- 29834252
TI  - Both Wrong and Right Methods Explained.

PMID- 29834254
TI  - Health and Economy.

PMID- 29834253
TI  - The Nation's Fund for Nurses.

PMID- 29834255
TI  - The Editor's Letter-Box.

PMID- 29834256
TI  - British Hospitals Association.

PMID- 29834258
TI  - The Norfolk Plan.

PMID- 29834257
TI  - Tropical Diseases in the Navy.

PMID- 29834260
TI  - An Invention to Convey the Meaning of Ordinary Print.

PMID- 29834259
TI  - Some Early Reports.

PMID- 29834261
TI  - The Film in Schools.

PMID- 29834262
TI  - The Tuberculosis Cure?

PMID- 29834264
TI  - The Breakdown in Training Mental Nurses.

PMID- 29834263
TI  - L10,000 for Portsmouth Hospital.

PMID- 29834266
TI  - Hospital and Institutional News.

PMID- 29834265
TI  - Private Nurses' Fees.

PMID- 29834267
TI  - Poverty and the Baby.

PMID- 29834268
TI  - The Queen at St. Bartholomew's.

PMID- 29834269
TI  - The Royal General Dispensary.

PMID- 29834270
TI  - Reply to Mrs. Stopes' Letter.

PMID- 29834271
TI  - The Health of School Children.

PMID- 29834272
TI  - Lay Service in Ambulance Work.

PMID- 29834274
TI  - Some Interesting Theories.

PMID- 29834273
TI  - Social Notes.

PMID- 29834276
TI  - The Principle of Patients' Payments.

PMID- 29834275
TI  - The Metropolitan Hospital.

PMID- 29834277
TI  - An Eventful Week.

PMID- 29834278
TI  - Hookworm Prevalence in England.

PMID- 29834279
TI  - Vaccination.

PMID- 29834280
TI  - Women in Industry.

PMID- 29834281
TI  - The New Pathological and Orthopaedic Blocks.

PMID- 29834282
TI  - Insured Patients and the Radcliffe Infirmary.

PMID- 29834283
TI  - Fever Nurses in Scotland.

PMID- 29834284
TI  - Regulation of Nurses' Hours.

PMID- 29834285
TI  - Certificated Blind Masseurs.

PMID- 29834286
TI  - Hospital and Institutional News.

PMID- 29834287
TI  - Dr. Addison and Cottage Nurses.

PMID- 29834288
TI  - What Is the Good of the College?

PMID- 29834289
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29834291
TI  - Congress of Universities.

PMID- 29834290
TI  - The Care of Crippled Children.

PMID- 29834293
TI  - Radiant Motherhood.

PMID- 29834292
TI  - International Health and the League.

PMID- 29834294
TI  - The Proposed Hospital Enquiry.

PMID- 29834295
TI  - Mental Treatment for Crime.

PMID- 29834297
TI  - The Place of the Medical Officer of Health.

PMID- 29834296
TI  - Extended Weekly Contributions in London.

PMID- 29834298
TI  - A Great Hospital for Egypt.

PMID- 29834299
TI  - Mr. Verity's Amalgamation Scheme.

PMID- 29834301
TI  - The Editor's Letter-Box.

PMID- 29834300
TI  - West Kent General Hospital.

PMID- 29834302
TI  - Round the Hospitals.

PMID- 29834303
TI  - Pressmen and Weekly Contributions.

PMID- 29834304
TI  - The Future of the Creche.

PMID- 29834305
TI  - An Old Comrade's Association.

PMID- 29834306
TI  - Association of Hospital Matrons.

PMID- 29834307
TI  - Adverse Report of the Local Advisory Committee.

PMID- 29834309
TI  - The Clean Milk Demonstration.

PMID- 29834308
TI  - Provision of Hospital Accommodation.

PMID- 29834311
TI  - The Middlesex Hospital's Exhibit.

PMID- 29834310
TI  - Efficiency in National Health.

PMID- 29834312
TI  - The Doctor's New Role.

PMID- 29834313
TI  - Efficiency at Olympia.

PMID- 29834314
TI  - St. Mary's on Medical Education.

PMID- 29834316
TI  - Good News for the Nation.

PMID- 29834315
TI  - The Draft Regulations under the Dangerous Drugs Act.

PMID- 29834318
TI  - Northampton's Feat.

PMID- 29834317
TI  - Royalty and St. Bartholomew's.

PMID- 29834319
TI  - Round the Hospitals.

PMID- 29834320
TI  - Discussion by the British Hospitals Association.

PMID- 29834321
TI  - Hospitals and the Approved Societies' Surplus.

PMID- 29834322
TI  - The Right of the Child.

PMID- 29834324
TI  - Winsley Sanatorium.

PMID- 29834323
TI  - Success of the Eight-Hour Day.

PMID- 29834326
TI  - Hospital and Institutional News.

PMID- 29834325
TI  - Achievements of the British Women's Hospital Committee.

PMID- 29834327
TI  - The Accumulated Health Insurance Funds.

PMID- 29834328
TI  - The Wellcome Historical Museum.

PMID- 29834329
TI  - Ambulance Facilities and Telephone Efficiency.

PMID- 29834331
TI  - A Great Social Experiment.

PMID- 29834330
TI  - Nurses and Trade Unions.

PMID- 29834332
TI  - The Health Ministry's Record.

PMID- 29834333
TI  - British Hospitals Association and Portsmouth.

PMID- 29834334
TI  - An Interesting Recital.

PMID- 29834335
TI  - Sickness Amongst Nurses.

PMID- 29834336
TI  - The Meldrum Forced-Draught Furnace.

PMID- 29834337
TI  - "Diet and Hygiene" Campaign.

PMID- 29834339
TI  - The Prevention of Crime.

PMID- 29834338
TI  - Should Nurses Smoke?

PMID- 29834340
TI  - Hospitals and Insured Persons' Fees.

PMID- 29834341
TI  - The Prince of Wales's Hospital, Cardiff.

PMID- 29834343
TI  - Greenock Nursing Association.

PMID- 29834342
TI  - The Pay of the Nurse: II. Under-paid Private Nurses.

PMID- 29834345
TI  - The Worker's Leisure.

PMID- 29834344
TI  - The Certificate of the Certifying Surgeon.

PMID- 29834346
TI  - International Tuberculosis Conference in London.

PMID- 29834347
TI  - General Nursing Council for Ireland.

PMID- 29834349
TI  - Round the Hospitals.

PMID- 29834348
TI  - Voluntary Hospital Staff Conference in Scotland.

PMID- 29834350
TI  - The Importance of an Educational Standard.

PMID- 29834351
TI  - Hospital and Institutional News.

PMID- 29834352
TI  - Annual Meetings of Hospitals.

PMID- 29834353
TI  - Parliament and the Professions.

PMID- 29834354
TI  - The Birth of a Great Profession.

PMID- 29834355
TI  - Passing Events and Topics.

PMID- 29834357
TI  - London's Record Epidemic.

PMID- 29834356
TI  - The Objects and Process of Its Manufacture.

PMID- 29834359
TI  - Investiture by the King.

PMID- 29834358
TI  - The Standardisation of Sera.

PMID- 29834360
TI  - The Human Factor in Industry.

PMID- 29834361
TI  - Dentists or Charlatans?

PMID- 29834362
TI  - Private Hospitals and the Trained Nurse's Responsibility.

PMID- 29834363
TI  - Small-Pox or Tuberculosis.

PMID- 29834364
TI  - Patients Pay L10,000.

PMID- 29834365
TI  - Red Cross Balance Distributed.

PMID- 29834367
TI  - A Higher Curriculum for Educated Probationers.

PMID- 29834366
TI  - The Problems of Venereal Disease.

PMID- 29834368
TI  - The Control of the Feeble-Minded.

PMID- 29834369
TI  - A Valuable Report to the Medical Research Council.

PMID- 29834371
TI  - Women in Industry.

PMID- 29834370
TI  - Farmers' Funds for Hospitals.

PMID- 29834372
TI  - The Truth about Medical Record Cards.

PMID- 29834373
TI  - Round the Hospitals.

PMID- 29834375
TI  - Proposed Extension to Professional Classes.

PMID- 29834374
TI  - Annual Meetings of Hospitals.

PMID- 29834377
TI  - The Under-Paid District Nurse.

PMID- 29834376
TI  - How Goes the Fight?

PMID- 29834379
TI  - Voluntary Hospital Staff Conference in Scotland.

PMID- 29834378
TI  - Welfare Work among Boys.

PMID- 29834380
TI  - The Ex-Service Welfare Society.

PMID- 29834381
TI  - The Way of Research.

PMID- 29834383
TI  - Hospital and Institutional News.

PMID- 29834382
TI  - Parliament and the Professions.

PMID- 29834384
TI  - The Venereal Report Appears.

PMID- 29834386
TI  - British Hospitals Association.

PMID- 29834385
TI  - Teacher or Nurse?

PMID- 29834388
TI  - Two Modern Schools and Hospitals.

PMID- 29834387
TI  - Passing Events and Topics.

PMID- 29834390
TI  - Clothing and Health.

PMID- 29834389
TI  - Public or Private Schools.

PMID- 29834392
TI  - The Story of a Great Change.

PMID- 29834391
TI  - The Medical Training of Missionaries.

PMID- 29834394
TI  - The Futility of Flogging.

PMID- 29834393
TI  - The Collective Voice of Medicine.

PMID- 29834396
TI  - What the Local Centres Are Doing.

PMID- 29834395
TI  - A Praiseworthy Investigation.

PMID- 29834397
TI  - A Postscript on Sunday Games.

PMID- 29834399
TI  - Parliament and the Professions.

PMID- 29834398
TI  - Hospital and Institutional News.

PMID- 29834400
TI  - Passing Events and Topics.

PMID- 29834401
TI  - Social Service in America.

PMID- 29834402
TI  - The Coming of the Mob.

PMID- 29834404
TI  - The Magazines of the Medical Schools.

PMID- 29834403
TI  - Truro Nursing Association.

PMID- 29834406
TI  - King Edward's Hospital Fund for London.

PMID- 29834405
TI  - Should Nurses Smoke?

PMID- 29834407
TI  - Round the Hospitals.

PMID- 29834408
TI  - The Castle of Indolence.

PMID- 29834410
TI  - The Almoner Question.

PMID- 29834409
TI  - Points from Annual Reports.

PMID- 29834411
TI  - The Healthy Heart.

PMID- 29834412
TI  - Annual Meetings of Hospitals and Societies.

PMID- 29834414
TI  - The Action of Animal Poisons.

PMID- 29834413
TI  - The Art of Keeping Clean.

PMID- 29834416
TI  - Marriage Law Reform.

PMID- 29834415
TI  - The State and Nursing Education.

PMID- 29834418
TI  - The College Nominations.

PMID- 29834417
TI  - Health by Knowledge.

PMID- 29834419
TI  - Unemployment Insurance: Minister's Decision.

PMID- 29834421
TI  - Paying Patients in Bermondsey Infirmary.

PMID- 29834420
TI  - Voluntary Hospitals Committee.

PMID- 29834423
TI  - Passing Events and Topics.

PMID- 29834422
TI  - Fielding Johnson of Leicester.

PMID- 29834425
TI  - British Hospitals Association.

PMID- 29834424
TI  - Anonymity for Young Criminals.

PMID- 29834427
TI  - The Nation's Fund for Nurses.

PMID- 29834426
TI  - Practical Uses and Advantages.

PMID- 29834429
TI  - The Pay of the Nurse: III. The Value of Board and Lodging.

PMID- 29834428
TI  - Erratum: Addendum.
AB  - [This corrects the article on p. 2 in vol. 69.].

PMID- 29834430
TI  - Medical Treatment of London Scholars.

PMID- 29834431
TI  - Hospital and Institutional News.

PMID- 29834433
TI  - Round the Hospitals.

PMID- 29834432
TI  - Conditions of Childbirth in India.

PMID- 29834434
TI  - Parliament and the Professions.

PMID- 29834435
TI  - Health Dangers in Unemployment.

PMID- 29834436
TI  - Wills of Medical Men.

PMID- 29834437
TI  - To Eat Well or to Live Ill.

PMID- 29834439
TI  - Should Nurses Smoke?

PMID- 29834438
TI  - Six Papers by Lord Lister.

PMID- 29834440
TI  - Interim Report of the Cave Committee.

PMID- 29834441
TI  - The Case against Maintenance Charges.

PMID- 29834443
TI  - The League of Mercy and Gifts in Kind.

PMID- 29834442
TI  - Annual Meetings of Hospitals and Societies.

PMID- 29834444
TI  - Ex-Service Men and a Sussex Hospital.

PMID- 29834445
TI  - The Almoner Question.

PMID- 29834447
TI  - Lord Denbigh's Idea.

PMID- 29834446
TI  - The Coming of the Mob.

PMID- 29834448
TI  - A Carefully Thought-Out System.

PMID- 29834449
TI  - Multiplication of the Unfit.

PMID- 29834450
TI  - Housing and Child Welfare.

PMID- 29834451
TI  - General Nursing Council for Scotland.

PMID- 29834452
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29834453
TI  - The Hospital Nursing Supplement.

PMID- 29834454
TI  - A Clerical Publican.

PMID- 29834455
TI  - Notes and News.

PMID- 29834456
TI  - Prescriptions and Their Owners.

PMID- 29834457
TI  - Everybody's Page.

PMID- 29834458
TI  - On the Pharmacology of Iron.

PMID- 29834459
TI  - The History and Capabilities of Herbal Simples: XXX.-The Dock.

PMID- 29834460
TI  - Voting Charities.

PMID- 29834462
TI  - The Lords' Committee.

PMID- 29834461
TI  - New Drugs and Appliances.

PMID- 29834464
TI  - Annotations.

PMID- 29834463
TI  - The Microscope in Medicine: XII.-The Examination of Urinary Deposits.

PMID- 29834465
TI  - Ingleby Lectures: Lecture III.

PMID- 29834466
TI  - Hepatic Colic.

PMID- 29834467
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834468
TI  - Ingleby Lectures: Lecture I.

PMID- 29834469
TI  - Radcliffe Infirmary, Oxford.

PMID- 29834470
TI  - Hospitals and Lifeboats.

PMID- 29834472
TI  - Shall Children Be Insured?

PMID- 29834471
TI  - Glottic Spasm.

PMID- 29834473
TI  - Annotations.

PMID- 29834474
TI  - The Hospital Nursing Supplement.

PMID- 29834476
TI  - Empyema of the Antrum of Highmore.

PMID- 29834475
TI  - Notes and News.

PMID- 29834477
TI  - Is Electricity Life?

PMID- 29834478
TI  - Poisons and Poisoners,-II: Arsenic: Madeline Smith.

PMID- 29834480
TI  - Everybody's Page.

PMID- 29834479
TI  - Epilepsy.

PMID- 29834482
TI  - New Drugs, Appliances, and Things Medical: Antiseptic Dressings, &c.

PMID- 29834481
TI  - The Treatment of Peritonitis.

PMID- 29834483
TI  - Fifty Thousand Pounds.

PMID- 29834484
TI  - Not All Condemned to Die.

PMID- 29834485
TI  - Notes and News.

PMID- 29834486
TI  - Ulcerative Endocarditis.

PMID- 29834488
TI  - A Vote of Confidence.

PMID- 29834487
TI  - The Microscope in Medicine: XI.-The Examination of Urinary Deposits.

PMID- 29834490
TI  - Annotations.

PMID- 29834489
TI  - Poisons and Poisoners: Arsenic: Madeline Smith.

PMID- 29834492
TI  - Higher Education for Women in America.

PMID- 29834491
TI  - A Hint from America.

PMID- 29834494
TI  - Trephining for Intracranial Pressure.

PMID- 29834493
TI  - Hydrastis Canadensis.

PMID- 29834495
TI  - The Hospital Nursing Supplement.

PMID- 29834496
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834498
TI  - The Aniline Dyes.

PMID- 29834497
TI  - The Disestablishment of the Poor House.

PMID- 29834499
TI  - The Hospital Nursing Supplement.

PMID- 29834500
TI  - Treatment of Appendicitis.

PMID- 29834502
TI  - Everybody's Page.

PMID- 29834501
TI  - The Ex-Premier and the Poet.

PMID- 29834503
TI  - Notes and News.

PMID- 29834504
TI  - The Indian Medical Service.

PMID- 29834506
TI  - Fathers Ancient and Modern.

PMID- 29834505
TI  - The History and Capabilities of Herbal Simples: XXXII.-Strawberries.

PMID- 29834507
TI  - Syringomyelia.-I.

PMID- 29834508
TI  - Annotations.

PMID- 29834509
TI  - Sugar of Milk.

PMID- 29834510
TI  - The Nude at the Seaside.

PMID- 29834511
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834512
TI  - Everybody's Page.

PMID- 29834513
TI  - Doctors and Directors.

PMID- 29834514
TI  - The Story of the Insane from Year to Year.

PMID- 29834515
TI  - Diseases of the Fingers : B-Paronychia.

PMID- 29834516
TI  - Annotations.

PMID- 29834518
TI  - Notes and News.

PMID- 29834517
TI  - A Bureau of Information.

PMID- 29834519
TI  - Co-Operative Production and Profit-Sharing.

PMID- 29834520
TI  - The Hospital Nursing Supplement.

PMID- 29834521
TI  - A Quarter of a Century of Medicine.

PMID- 29834522
TI  - Gastrectasis.

PMID- 29834523
TI  - Annotations.

PMID- 29834525
TI  - Diseases of the Fingers: C.-Contractions.

PMID- 29834524
TI  - "Mad Doctors"-A Protest.

PMID- 29834526
TI  - The Hospital Nursing Supplement.

PMID- 29834527
TI  - Rheumatic Hyperpyrexia.

PMID- 29834529
TI  - The Story of the Insane from Year to Year.

PMID- 29834528
TI  - Notes and News.

PMID- 29834530
TI  - Everybody's Page.

PMID- 29834531
TI  - Treatment of Otorrhoea.

PMID- 29834533
TI  - Recreation in Relation to the Health of the People: VII. Among the Mining
      Population.

PMID- 29834532
TI  - The International Congress of Hygiene and Demography.

PMID- 29834535
TI  - English Lunacy in 1890.

PMID- 29834534
TI  - The Personal Element.

PMID- 29834537
TI  - Annotations.

PMID- 29834536
TI  - The History and Capabilities of Herbal Simples: XXXVI.-Ferns.

PMID- 29834538
TI  - Notes and News.

PMID- 29834539
TI  - Facts for Preachers and Speakers.

PMID- 29834540
TI  - The Hospital Nursing Supplement.

PMID- 29834541
TI  - Metropolitan National Nursing Association.

PMID- 29834542
TI  - Medical Sanity.

PMID- 29834543
TI  - A Live-Long Day.

PMID- 29834545
TI  - Shall the Radcliffe Infirmary Be Rebuilt?

PMID- 29834544
TI  - Hospital Sunday.

PMID- 29834547
TI  - Ingleby Lectures: Lecture II.-The Injuries of Bones.

PMID- 29834546
TI  - Under Which Flag?

PMID- 29834549
TI  - Bassorin Paste.

PMID- 29834548
TI  - The Hospital Nursing Supplement.

PMID- 29834551
TI  - A Good Example.

PMID- 29834550
TI  - Everybody's Page.

PMID- 29834553
TI  - The Old Family Doctor.

PMID- 29834552
TI  - Notes and News.

PMID- 29834555
TI  - Annotations.

PMID- 29834554
TI  - Tract Ninety-One : An Oxford Object Lesson.

PMID- 29834556
TI  - The Radcliffe Infirmary, Oxford.

PMID- 29834557
TI  - Professional Labels.

PMID- 29834558
TI  - Cold Baths in Typhoid Fever.

PMID- 29834559
TI  - The British Pasteur Institute.

PMID- 29834561
TI  - Poison and Poisoners: Aconitia; Dr. Lamson.

PMID- 29834560
TI  - Absorption of Fats.

PMID- 29834562
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834563
TI  - The Action of Caffeine, Morphine, Atropine, Ergot, and Digitalis on the Arterial
      Blood Pressure.

PMID- 29834564
TI  - Annotations.

PMID- 29834565
TI  - Literature and Science.

PMID- 29834566
TI  - Trained Attendants and Nurses for the Insane.

PMID- 29834567
TI  - Bazaars and Bankruptcy.

PMID- 29834568
TI  - Everybody's Page.

PMID- 29834569
TI  - The Hospital Nursing Supplement.

PMID- 29834570
TI  - Notes and News.

PMID- 29834571
TI  - Syringomyelia.-II.

PMID- 29834572
TI  - The Surgery of the Spinal Cord.

PMID- 29834573
TI  - Annotations.

PMID- 29834574
TI  - Notes and News.

PMID- 29834575
TI  - Eugenia Jambolana in Diabetes Mellitus.

PMID- 29834577
TI  - Portals of Health.

PMID- 29834576
TI  - Everybody's Page.

PMID- 29834578
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834579
TI  - Results.

PMID- 29834580
TI  - Neuritis of the Peripheral Nerves, III.

PMID- 29834582
TI  - The Teaching of Hygiene in Board Schools.

PMID- 29834581
TI  - The Influenza.

PMID- 29834584
TI  - The Hospital Nursing Supplement.

PMID- 29834583
TI  - The R.B.N.A. at Bay.

PMID- 29834586
TI  - Derby and Oxford.

PMID- 29834585
TI  - Editor's Letter Box.

PMID- 29834588
TI  - The Duke and the Hospital.

PMID- 29834587
TI  - The Surgery of Joints.

PMID- 29834590
TI  - Can a Sixpenny Doctor Be Honest?

PMID- 29834589
TI  - The Hospital Nursing Supplement.

PMID- 29834592
TI  - Employments for Women: I. Lady Dressmakers.

PMID- 29834591
TI  - Annotations.

PMID- 29834593
TI  - Harvey: An Experimenter.

PMID- 29834594
TI  - Notes and News.

PMID- 29834595
TI  - The Estimation of Hydrochloric Acid in Gastric Disorders.

PMID- 29834596
TI  - The Programme of the Hospital Saturday Fund.

PMID- 29834598
TI  - Everybody's Page.

PMID- 29834597
TI  - The History of Capabilities of Herbal Simples: XXXV.-Eyebright.

PMID- 29834599
TI  - The Rational Treatment of Serous Iritis.

PMID- 29834601
TI  - Iodide of Potash.

PMID- 29834600
TI  - Doctors' Fees.

PMID- 29834602
TI  - The Story of the Insane from Year to Year.

PMID- 29834603
TI  - Annotations.

PMID- 29834604
TI  - Lady Strangford Hospital, Port Said.

PMID- 29834605
TI  - On the Use of Creosote in Phthisis.

PMID- 29834606
TI  - Employments for Women: III. Gardening.

PMID- 29834607
TI  - The Hospital Nursing Supplement.

PMID- 29834609
TI  - Notes and News.

PMID- 29834608
TI  - Municipalities and Public Health.

PMID- 29834610
TI  - Diseases of the Fingers : C-Contractions.

PMID- 29834611
TI  - Rooks and Retribution.

PMID- 29834612
TI  - More Than Brothers.

PMID- 29834613
TI  - On the Action of Salicylates in Certain Rheumatic Diseases.

PMID- 29834614
TI  - Everybody's Page.

PMID- 29834615
TI  - Gastrectasis B-Diagnosis.

PMID- 29834617
TI  - The Radcliffe Infirmary, Oxford.

PMID- 29834616
TI  - Everybody's Page.

PMID- 29834619
TI  - Vivisection Questioned.

PMID- 29834618
TI  - Renal Torpidity.

PMID- 29834621
TI  - Quebracho.

PMID- 29834620
TI  - The Hospital Nursing Supplement.

PMID- 29834623
TI  - The Norwich Neophyte.

PMID- 29834622
TI  - Costly Sacrifices.

PMID- 29834625
TI  - Annotations.

PMID- 29834624
TI  - Notes and News.

PMID- 29834626
TI  - Carbuncle and Furuncle.

PMID- 29834627
TI  - Neuritis of the Peripheral Nerves.

PMID- 29834628
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834629
TI  - Ingleby Lectures: Lecture VI: Naevus.

PMID- 29834631
TI  - On the Chemistry and Physiological Action of the Salicyl Compounds.

PMID- 29834630
TI  - Suburban Doctors and Suburban Hospitals.

PMID- 29834632
TI  - Diseases of the Fingers D.-Diseases of the Phalangeal Bones and Joints.

PMID- 29834633
TI  - Hypnotism.

PMID- 29834634
TI  - Everybody's Page.

PMID- 29834635
TI  - The Hospital Nursing Supplement.

PMID- 29834636
TI  - Annotations.

PMID- 29834637
TI  - The Eastern Hospital Inquiry: The Report of the Local Government Board.

PMID- 29834639
TI  - Notes and News.

PMID- 29834638
TI  - A Gift of Days.

PMID- 29834641
TI  - Gastrectasis. C-Treatment.

PMID- 29834640
TI  - Wanted Fair Play for the Voluntary Hospitals.

PMID- 29834642
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834643
TI  - Oxford on Its Mettle.

PMID- 29834644
TI  - The Lords' Committee.

PMID- 29834645
TI  - Charity Dinners.

PMID- 29834647
TI  - The Cholera.

PMID- 29834646
TI  - Sale of Professor Koch's Lymph.

PMID- 29834648
TI  - Euphrasia Officinalis.

PMID- 29834650
TI  - Natura Non Facit Saltum.

PMID- 29834649
TI  - The Microscope in Medicine: XIV.-The Examination of Vomit, Faeces, and Morbid
      Fluids.

PMID- 29834652
TI  - Everybody's Page.

PMID- 29834651
TI  - Notes and News.

PMID- 29834654
TI  - Ingleby Lectures: Lecture V.

PMID- 29834653
TI  - The Hospital Nursing Supplement.

PMID- 29834656
TI  - New Drugs, Appliances, and Things Medical: The "Titan" Patent Soap.

PMID- 29834655
TI  - Annotations.

PMID- 29834657
TI  - Hydrochlorate of Phenocoll.

PMID- 29834658
TI  - Diseases of the Fingers : A.-The Nails.

PMID- 29834659
TI  - Recreation in Relation to the Health of the People: VI. In the Country.

PMID- 29834660
TI  - On Some Points in the Ordinary Process of Inflammation.

PMID- 29834661
TI  - Husbands.

PMID- 29834662
TI  - The Princess and the Second Thousand.

PMID- 29834664
TI  - The Beginning of the End.

PMID- 29834663
TI  - Metropolitan Hospital Sunday Fund, 1891.

PMID- 29834666
TI  - Proposed Alterations at the Oxford Infirmary.

PMID- 29834665
TI  - Annotations.

PMID- 29834667
TI  - The Hospital Nursing Supplement.

PMID- 29834668
TI  - Notes and News.

PMID- 29834670
TI  - Everybody's Page.

PMID- 29834669
TI  - Everybody's Page.

PMID- 29834672
TI  - Styrone.

PMID- 29834671
TI  - The Infinitely Small.

PMID- 29834674
TI  - Annotations.

PMID- 29834673
TI  - Varix of the Tongue.

PMID- 29834676
TI  - Influenza.

PMID- 29834675
TI  - The Programme of the Saturday Fund.

PMID- 29834678
TI  - Articles of Scientific Faith.

PMID- 29834677
TI  - The History and Capabilities of Herbal Simples: XXXIII.-The Elder-Elecampane.

PMID- 29834680
TI  - The Hospital Nursing Supplement.

PMID- 29834679
TI  - Deviations of the Nasal Septum.

PMID- 29834681
TI  - Notes and News.

PMID- 29834682
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834683
TI  - Recreation in Relation to the Health of the People: IV. Recreation for the Mind.

PMID- 29834684
TI  - Annotations.

PMID- 29834686
TI  - A Disgraceful West-End Club.

PMID- 29834685
TI  - On the Side of the Commandments.

PMID- 29834687
TI  - The University of Strasburg.

PMID- 29834688
TI  - Recreation in Relation to the Health of the People: V. Recreation for the Body.

PMID- 29834689
TI  - The Surgical Treatment of Purulent Pericarditis.

PMID- 29834690
TI  - The Source of the Bile Pigment.

PMID- 29834692
TI  - The Hospital Nursing Supplement.

PMID- 29834691
TI  - The Programme of the Hospital Saturday Fund.

PMID- 29834693
TI  - Pulsatilla.

PMID- 29834694
TI  - Notes and News.

PMID- 29834695
TI  - Everybody's Page.

PMID- 29834696
TI  - The History and Capabilities of Herbal Simples: XXXIV.-Fennel.

PMID- 29834697
TI  - The Treatment of Whooping Cough.

PMID- 29834698
TI  - The Pathology and Treatment of Erysipelas.

PMID- 29834699
TI  - Antiseptics in Obstetric Nursing.

PMID- 29834700
TI  - Employments for Women: II. Type-Writing for Ladies.

PMID- 29834701
TI  - Preparing for Flight.

PMID- 29834702
TI  - Annotations.

PMID- 29834703
TI  - Notes and News.

PMID- 29834704
TI  - The Hospital Nursing Supplement.

PMID- 29834705
TI  - The Princess of Wales' Fund for Mrs. Grimwood.

PMID- 29834706
TI  - Everybody's Page.

PMID- 29834708
TI  - "Continentalising" the Sunday.

PMID- 29834707
TI  - The National Liver.

PMID- 29834709
TI  - Surgery of the Pericardium.

PMID- 29834710
TI  - Auscultatory Percussion.

PMID- 29834711
TI  - Thuja Occidentalis.

PMID- 29834712
TI  - The Lords' Committee.

PMID- 29834713
TI  - London Samaritan Society's Convalescent Homes.

PMID- 29834714
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834715
TI  - The Radcliffe Infirmary, Oxford.

PMID- 29834716
TI  - The Hospital Nursing Supplement.

PMID- 29834718
TI  - Prescriptions and Their Owners.

PMID- 29834717
TI  - New Drugs Appliances, and Things Medical: Coca-Wine-Pure Cane Sugar.

PMID- 29834719
TI  - Notes and News.

PMID- 29834721
TI  - An Early Victim.

PMID- 29834720
TI  - Is Philanthropy a Duty?

PMID- 29834723
TI  - A Funeral Oration.

PMID- 29834722
TI  - The Microscope in Medicine: XIII.-Examination of the Blood.

PMID- 29834725
TI  - Died of Acute Pneumonia.

PMID- 29834724
TI  - Ingleby Lectures : Lecture IV.

PMID- 29834726
TI  - Anaemia.

PMID- 29834727
TI  - Turning over New Leaves.

PMID- 29834729
TI  - Piperazidine.

PMID- 29834728
TI  - The Royal British Nurses' Association and the Nurse Training Schools.

PMID- 29834730
TI  - Annotations.

PMID- 29834731
TI  - Scotch Medical Schools.

PMID- 29834733
TI  - On Some Points in the Treatment of Diabetes-II.

PMID- 29834732
TI  - How Doctors Are Made.

PMID- 29834735
TI  - The Hospital Nursing Supplement.

PMID- 29834734
TI  - The Histology of the Conscience.

PMID- 29834737
TI  - Medicine as a Calling.

PMID- 29834736
TI  - Annotations.

PMID- 29834739
TI  - The Stress and Strain of Medicine.

PMID- 29834738
TI  - Diseases of the Fingers: F-Abnormalities of Circulation.

PMID- 29834741
TI  - The Existence of a Phthisical Contagium.

PMID- 29834740
TI  - Notes and News.

PMID- 29834743
TI  - Cactus Grandiflora.

PMID- 29834742
TI  - The Manchester Chloroform Cases.

PMID- 29834744
TI  - Sterno-Mastoid Tumour.

PMID- 29834745
TI  - The Programme of the Hospital Saturday Fund.

PMID- 29834746
TI  - The Hospital Nursing Supplement.

PMID- 29834747
TI  - Everybody's Page.

PMID- 29834749
TI  - Swansea Hospital.

PMID- 29834748
TI  - Annotations.

PMID- 29834750
TI  - Influenza.

PMID- 29834751
TI  - Home for the Dying.

PMID- 29834752
TI  - Mad from Life's History.

PMID- 29834753
TI  - The Lords' Committee.

PMID- 29834754
TI  - Naevoid Lipoma and Its Association with Hypertrophy of the Toes.

PMID- 29834755
TI  - Annotations.

PMID- 29834756
TI  - The Hospital Nursing Supplement.

PMID- 29834757
TI  - Dr. A. R. Wallace and the Vaccination Commission.

PMID- 29834758
TI  - The Position of the Provincial Medical Schools.

PMID- 29834759
TI  - Ametropia and the Cardio-Vascular System.

PMID- 29834760
TI  - Everybody's Page.

PMID- 29834761
TI  - Shall Nurses Cease to Be Lay Women?-I.

PMID- 29834762
TI  - The Story of the Insane from Year to Year.

PMID- 29834763
TI  - Diseases of the Fingers: E.-Diseases of the Tendons.

PMID- 29834764
TI  - The Bodies and Minds of Children.

PMID- 29834765
TI  - Some Points in the Treatment of Diabetes-I.

PMID- 29834766
TI  - Notes and News.

PMID- 29834767
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834768
TI  - The Dangers of Chloroform.

PMID- 29834769
TI  - Midnight Oil or Midnight Sleep?

PMID- 29834770
TI  - The Hospital Nursing Supplement.

PMID- 29834772
TI  - Medicus Nascitur, Non Fit.

PMID- 29834771
TI  - Annotations.

PMID- 29834774
TI  - Shall Nurses Cease to Be Laywomen?-II.

PMID- 29834773
TI  - Some Points in the Diagnosis of Hip Disease in Children.

PMID- 29834776
TI  - Corn and Husks.

PMID- 29834775
TI  - Notes and News.

PMID- 29834777
TI  - Everybody's Page.

PMID- 29834778
TI  - How Doctors Are Made.

PMID- 29834779
TI  - Somnal.

PMID- 29834780
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834782
TI  - Shall Nurses Cease to Be Laywomen?-III.

PMID- 29834781
TI  - Diseases of the Fingers: G.-The Skin, &c.

PMID- 29834784
TI  - Everybody's Page.

PMID- 29834783
TI  - The Woman Question in India.

PMID- 29834786
TI  - New Drugs, Appliances, and Things Medical: New Nurses' Case.

PMID- 29834785
TI  - Village Anthropology.

PMID- 29834787
TI  - Notes and News.

PMID- 29834788
TI  - Genu Valgum.-I.

PMID- 29834790
TI  - Haematuria : The Diagnosis of Its Cause.

PMID- 29834789
TI  - Cycling and Health.

PMID- 29834791
TI  - Annotations.

PMID- 29834792
TI  - Some Ludicrous Aspects of Human Misery.

PMID- 29834793
TI  - The Hospital Nursing Supplement.

PMID- 29834794
TI  - Antiseptic Treatment of Typhoid Fever.

PMID- 29834796
TI  - Dust and Disease.

PMID- 29834795
TI  - Repentance.

PMID- 29834797
TI  - Physic, Law, and Drunkenness.

PMID- 29834798
TI  - Everybody's Page.

PMID- 29834800
TI  - Treatment of Abscesses in Cavities with Rigid Walls.

PMID- 29834799
TI  - Scleroderma.

PMID- 29834801
TI  - A Sermon for the Kitchen.

PMID- 29834802
TI  - The Hospital Problem: I.-Hospital Income and Expenditure.

PMID- 29834803
TI  - Paracentesis in Empyema.

PMID- 29834804
TI  - Cure of Flat-Foot by Message.

PMID- 29834805
TI  - The History and Capabilities of Herbal Simples: VI.-The Common Barberry-Sweet
      Basil.

PMID- 29834806
TI  - Annotations.

PMID- 29834807
TI  - Diagnosis and Treatment of the Several Forms of Rheumatism.

PMID- 29834808
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834809
TI  - Dengue in Europe.

PMID- 29834810
TI  - Arrest of Erysipelas.

PMID- 29834811
TI  - Cystinuria.

PMID- 29834812
TI  - The Taunton and Somerset Hospital.

PMID- 29834813
TI  - Cutis Laxa.

PMID- 29834814
TI  - The Nursing Supplement.

PMID- 29834815
TI  - Notes and News.

PMID- 29834816
TI  - Iodoform in Articular Tuberculosis.

PMID- 29834818
TI  - Prevention of Vomiting.

PMID- 29834817
TI  - Colour Blindness.

PMID- 29834820
TI  - Evacuation of Vertebral and Psoas Abscesses.

PMID- 29834819
TI  - Reduction of Strangulated Herniae by Coughing.

PMID- 29834821
TI  - Small Special Hospitals.

PMID- 29834822
TI  - St. George's Hospital.

PMID- 29834823
TI  - Everybody's Page.

PMID- 29834824
TI  - Forgiveness of Sin.

PMID- 29834825
TI  - The Sheffield Medical School.

PMID- 29834826
TI  - St. Thomas's Hospital.

PMID- 29834827
TI  - Fracture Patella.

PMID- 29834828
TI  - The Nursing Supplement.

PMID- 29834829
TI  - Introductory Addresses.

PMID- 29834830
TI  - Westminster Hospital.

PMID- 29834831
TI  - The Yorkshire College, Leeds.

PMID- 29834832
TI  - New Drugs, Appliances, and Things Medical: "Christia" and Modern Day Poultices.

PMID- 29834833
TI  - Bumbledom at Birmingham.

PMID- 29834834
TI  - A Fresh Start.

PMID- 29834835
TI  - Annotations.

PMID- 29834836
TI  - Royal Hospital for Diseases of the Chest.

PMID- 29834838
TI  - Microbes.

PMID- 29834837
TI  - Notes and News.

PMID- 29834839
TI  - Scurvy.

PMID- 29834840
TI  - Ainhum.

PMID- 29834841
TI  - Progressive Paralysis.

PMID- 29834842
TI  - Transfusion of Blood.

PMID- 29834844
TI  - A Phase of Modern Medicine.

PMID- 29834843
TI  - The Borderland of Madness.

PMID- 29834845
TI  - Detection of Human Blood.

PMID- 29834847
TI  - University College Hospital.

PMID- 29834846
TI  - Hypnotism.

PMID- 29834848
TI  - Acute Catarrh of the Stomach.

PMID- 29834849
TI  - The Hospital for the Insane.

PMID- 29834850
TI  - Methyl-Acetandilide.

PMID- 29834851
TI  - The Way They Died Then.

PMID- 29834853
TI  - Exophthalmic Goitre.

PMID- 29834852
TI  - Everybody's Page.

PMID- 29834855
TI  - Mourning.

PMID- 29834854
TI  - Notes and News.

PMID- 29834856
TI  - Spending, Mending, or Ending.

PMID- 29834857
TI  - Difficult Diagnosis.

PMID- 29834858
TI  - Annotations.

PMID- 29834859
TI  - Hampstead Provident Dispensary.

PMID- 29834860
TI  - Impurites of Salicylic Acid.

PMID- 29834861
TI  - Acetanilide in Enteric Fever.

PMID- 29834862
TI  - A Sunday Lecturer.

PMID- 29834863
TI  - Hepatic Abscess.

PMID- 29834865
TI  - West of England Sanatorium.

PMID- 29834864
TI  - Naphthol in Dyspepsia.

PMID- 29834866
TI  - The Nursing Supplement.

PMID- 29834867
TI  - The Hospital Problem: III.-Hospital Audit and Bookkeeping.

PMID- 29834869
TI  - Stricture.

PMID- 29834868
TI  - The Constitution of Man.

PMID- 29834870
TI  - Cottage Industries in Scotland.

PMID- 29834871
TI  - Proteid Poisons of Jequirity.

PMID- 29834873
TI  - New Drugs, Appliances, and Things Medical: Chancellors' Budgets and Cadbury's
      Cocoa.

PMID- 29834872
TI  - Changes after Death.

PMID- 29834874
TI  - Everybody's Page.

PMID- 29834875
TI  - Shock.

PMID- 29834876
TI  - National Pension Fund for Nurses.

PMID- 29834877
TI  - Foreign Bodies in the Eye.

PMID- 29834878
TI  - Physiological Candles.

PMID- 29834879
TI  - Notes and News.

PMID- 29834880
TI  - Annotations.

PMID- 29834881
TI  - The Sure Foundation.

PMID- 29834882
TI  - Transfusion.

PMID- 29834883
TI  - In the Wards at the Royal Free.

PMID- 29834885
TI  - Hospital Doctors under Surveillance.

PMID- 29834884
TI  - Ethical.

PMID- 29834886
TI  - The Nursing Supplement.

PMID- 29834888
TI  - Purpura.

PMID- 29834887
TI  - The Christian Church and the Bodily Health.

PMID- 29834889
TI  - Antiseptics.

PMID- 29834890
TI  - Treatment of Goitre by Electricity.

PMID- 29834892
TI  - The Doctor's Domestic Intellect.

PMID- 29834891
TI  - Noises in the Ears.

PMID- 29834894
TI  - The Nursing Supplement.

PMID- 29834893
TI  - Antiseptic after Treatment of Vaccination.

PMID- 29834895
TI  - Everybody's Page.

PMID- 29834896
TI  - The Squandering of Posthumous Gifts to Charity.

PMID- 29834898
TI  - Annotations.

PMID- 29834897
TI  - Good Friday.

PMID- 29834899
TI  - Dangers of Sulphonal.

PMID- 29834900
TI  - Penitentiary Patients.

PMID- 29834902
TI  - The Doctor in History.

PMID- 29834901
TI  - Notes and News.

PMID- 29834904
TI  - A True Stomachic.

PMID- 29834903
TI  - Excipient for External Application.

PMID- 29834906
TI  - Balsam of Peru in Phthisis.

PMID- 29834905
TI  - New Drugs, Appliances, and Things Medical: Robinson's Patent Groats and Patent
      Barley.

PMID- 29834907
TI  - Dieulafoy on the Treatment of Asthma.

PMID- 29834908
TI  - Treatment of Dengue.

PMID- 29834909
TI  - Oil of Eucalyptus in Scarlatina and Other Infectious Diseases.

PMID- 29834910
TI  - Out of Physic: Into-What?

PMID- 29834911
TI  - In the Wards at Great Ormond-Street Hospital for Children.

PMID- 29834912
TI  - Annotations.

PMID- 29834914
TI  - Below Par.

PMID- 29834913
TI  - The Practitioner's Outlook and Retrospect.

PMID- 29834916
TI  - Unqualified Assistants and Death Certificates.

PMID- 29834915
TI  - The Story of the Insane from Year to Year: Asylum Reports: Summary.

PMID- 29834917
TI  - Notes and News.

PMID- 29834918
TI  - Everybody's Page.

PMID- 29834919
TI  - German System of National Insurance.

PMID- 29834920
TI  - Peace.

PMID- 29834921
TI  - London Empty.

PMID- 29834922
TI  - The Nursing Supplement.

PMID- 29834923
TI  - Heredity.

PMID- 29834924
TI  - Removal of Accessory Limb.

PMID- 29834925
TI  - Notes and News.

PMID- 29834926
TI  - The General Hospital at Birmingham.

PMID- 29834928
TI  - Salol.

PMID- 29834927
TI  - The Nursing Supplement.

PMID- 29834929
TI  - Necrosis of the Jaw.

PMID- 29834930
TI  - Phthisis.

PMID- 29834932
TI  - Joy.

PMID- 29834931
TI  - Conscience.

PMID- 29834933
TI  - The Work of the Hospitals Association.

PMID- 29834934
TI  - Lithotomy.

PMID- 29834935
TI  - Ovarian Disease.

PMID- 29834936
TI  - Sea-Sickness.

PMID- 29834937
TI  - Everybody's Page.

PMID- 29834938
TI  - Physiological Candles: Development.

PMID- 29834939
TI  - The Royal Chest Hospital Scandal: A Statement of the Facts.

PMID- 29834940
TI  - Annotations.

PMID- 29834942
TI  - Temperature.

PMID- 29834941
TI  - Cancer.

PMID- 29834944
TI  - Notes and News.

PMID- 29834943
TI  - Dentition.

PMID- 29834945
TI  - Ought Members of the Active Medical Staff to Sit upon Hospital Boards?

PMID- 29834946
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834947
TI  - Acne.

PMID- 29834948
TI  - Hospital Book-Keeping and Accounts.

PMID- 29834949
TI  - An Impeached Committee.

PMID- 29834950
TI  - The Nursing Supplement.

PMID- 29834951
TI  - Vaccination.

PMID- 29834952
TI  - The Hospital Problem: II.-What Is Wanted.

PMID- 29834953
TI  - The Town Dweller: Life in Town and Country.

PMID- 29834954
TI  - Unstable Mental Equilibrium.

PMID- 29834955
TI  - Fracture of the Patella.

PMID- 29834956
TI  - Mikulicz's Operation.

PMID- 29834957
TI  - Injuries of the Neck of the Femur.

PMID- 29834958
TI  - Statistics of Insanity in England.

PMID- 29834959
TI  - Herpes Zoster.

PMID- 29834960
TI  - Hernia.

PMID- 29834961
TI  - Perseverance.

PMID- 29834963
TI  - Doctors' Fees in Germany.

PMID- 29834962
TI  - "Working Men" and Hospital Committees.

PMID- 29834964
TI  - The Right to Perform Operations in Hospitals.

PMID- 29834965
TI  - Electricity.

PMID- 29834966
TI  - Everybody's Page.

PMID- 29834967
TI  - Annotations.

PMID- 29834968
TI  - Distribution of Disease.

PMID- 29834969
TI  - Notes and News.

PMID- 29834970
TI  - Everybody's Page.

PMID- 29834972
TI  - Annotations.

PMID- 29834971
TI  - A Bishop's Ambition.

PMID- 29834973
TI  - Physiological Candles: "Wonder" or "Form".

PMID- 29834974
TI  - Military Hygiene.

PMID- 29834975
TI  - Sulphonal.

PMID- 29834976
TI  - The General Practitioners and Dr. Rentoul's Scheme.

PMID- 29834977
TI  - Popular Pastimes as Aids to Hospital Funds.

PMID- 29834979
TI  - Thoughts.

PMID- 29834978
TI  - Travelling for Health.

PMID- 29834980
TI  - The Nursing Supplement.

PMID- 29834981
TI  - The Cesspools of Chichester: A Courageous Speech.

PMID- 29834982
TI  - Spinal Injuries.

PMID- 29834983
TI  - The Birmingham General Dispensary.

PMID- 29834984
TI  - Hammer Nose.

PMID- 29834985
TI  - The Electro-Magnet in Ophthalmic Surgery.

PMID- 29834986
TI  - Scrofula.

PMID- 29834987
TI  - Hypnotism or Mesmerism.

PMID- 29834988
TI  - Professional Pressure.

PMID- 29834989
TI  - The Clapham Maternity Hospital.

PMID- 29834990
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29834992
TI  - Cooks and Cooking.

PMID- 29834991
TI  - Modern Socialism.

PMID- 29834993
TI  - Bleeding.

PMID- 29834994
TI  - Heredity.

PMID- 29834995
TI  - Locomotor Ataxy.

PMID- 29834996
TI  - Cases Treated by Ice.

PMID- 29834997
TI  - Notes and News.

PMID- 29834999
TI  - Everybody's Page.

PMID- 29834998
TI  - Antiseptic Ventilation for Hospitals and Sanatoriums.

PMID- 29835001
TI  - The Medication of the Mind.

PMID- 29835000
TI  - The Jaffray Suburban Hospital, Birmingham.

PMID- 29835003
TI  - Annotations.

PMID- 29835002
TI  - Microbes.

PMID- 29835005
TI  - Hernia Cerebri.

PMID- 29835004
TI  - Long Suffering.

PMID- 29835006
TI  - Phthisis.

PMID- 29835007
TI  - Trephining for Epilepsy.

PMID- 29835008
TI  - Typhoid Fevers.

PMID- 29835009
TI  - Invalid Children's Aid Association.

PMID- 29835010
TI  - Albuminuria in Pregnacy.

PMID- 29835011
TI  - Notes and News.

PMID- 29835013
TI  - Pernicious Anaemia.

PMID- 29835012
TI  - Everybody's Page.

PMID- 29835014
TI  - Alcohol in Medicine.

PMID- 29835015
TI  - Atropine.

PMID- 29835017
TI  - An Asylum Infirmary for 100 Beds: With Full Plans.

PMID- 29835016
TI  - Joy.

PMID- 29835018
TI  - Treatment of Yellow Fever.

PMID- 29835019
TI  - Help for the London Poor.

PMID- 29835021
TI  - Charitable Appeals and Charities.

PMID- 29835020
TI  - A Home to Die in.

PMID- 29835022
TI  - Annotations.

PMID- 29835023
TI  - The Nursing Supplement.

PMID- 29835025
TI  - Prayer.

PMID- 29835024
TI  - The Ice Treatment.

PMID- 29835026
TI  - The Birmingham District Nursing Society.

PMID- 29835027
TI  - Morphia Injections.

PMID- 29835028
TI  - Antipyrin, &c.

PMID- 29835029
TI  - Classification of the Poor in Workhouses.

PMID- 29835030
TI  - Notes and News.

PMID- 29835031
TI  - Hypnotism v. Dypsomania.

PMID- 29835032
TI  - Annotations.

PMID- 29835033
TI  - The Home of Rest for Horses.

PMID- 29835034
TI  - The Queen's Hospital, Birmingham.

PMID- 29835035
TI  - Quinine.

PMID- 29835036
TI  - Life and Living.

PMID- 29835037
TI  - The Hospitals Again Vindicated!

PMID- 29835038
TI  - The Nursing Supplement.

PMID- 29835039
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29835040
TI  - Within the Wards: Some Probable Causes of Cancer.

PMID- 29835041
TI  - Antefebrin.

PMID- 29835042
TI  - Everybody's Page.

PMID- 29835043
TI  - Hyoscine as a Sedative.

PMID- 29835044
TI  - Paradise.

PMID- 29835045
TI  - Nutrition and Propagation of Flowers and Trees.

PMID- 29835047
TI  - John Chinaman, M.D.

PMID- 29835046
TI  - Scarlatina Treatment and Results.

PMID- 29835048
TI  - Antiseptic Drainage of the Lung.

PMID- 29835049
TI  - Ununited Fractures.

PMID- 29835050
TI  - The Proposed Registration of Nurses.

PMID- 29835051
TI  - Goodwill Towards Men.

PMID- 29835053
TI  - Renal Calculi.

PMID- 29835052
TI  - Everybody's Page.

PMID- 29835054
TI  - Presystolic Murmur.

PMID- 29835055
TI  - Surgical Cases.

PMID- 29835057
TI  - Malaria v. More Recognisable Causes of Disease.

PMID- 29835056
TI  - The Nursing Supplement.

PMID- 29835058
TI  - M. Daudet's Darwinism.

PMID- 29835059
TI  - Surgical Dressings.

PMID- 29835060
TI  - The Registration of Nurses.

PMID- 29835061
TI  - Leprosy.

PMID- 29835062
TI  - Going Abroad.

PMID- 29835063
TI  - Hysteria in the Male.

PMID- 29835064
TI  - Appeals.

PMID- 29835065
TI  - King's College Hospital.

PMID- 29835066
TI  - A Suburban Medical Lecture.

PMID- 29835068
TI  - Notes and News.

PMID- 29835067
TI  - The British Nurses' Association and the Medical Council.

PMID- 29835069
TI  - Annotations.

PMID- 29835070
TI  - Alcoholic Paralysis.

PMID- 29835072
TI  - The Nursing Supplement.

PMID- 29835071
TI  - New Drugs, Appliances, and Things Medical: The Derbyshire Respirator.

PMID- 29835073
TI  - Confusion Worse Confounded.

PMID- 29835074
TI  - January.

PMID- 29835075
TI  - Annotations.

PMID- 29835076
TI  - The Philanthropist's Vade Mecum.

PMID- 29835078
TI  - Notes and News.

PMID- 29835077
TI  - The History and Capabilities of Herbal Simples: II. A Eulogy, and Some Ancient
      Authorities.

PMID- 29835079
TI  - A Happy New Year.

PMID- 29835080
TI  - A Promise of Dawn.

PMID- 29835081
TI  - Everybody's Page.

PMID- 29835082
TI  - Uterine Cancer.

PMID- 29835084
TI  - Tubercle Infection.

PMID- 29835083
TI  - Secretaries and Their Limitations.

PMID- 29835085
TI  - Annotations.

PMID- 29835086
TI  - Muscular Atrophy in Tabes Dorsalis.

PMID- 29835087
TI  - No More Insomnia.

PMID- 29835088
TI  - Hypnotism.

PMID- 29835089
TI  - Accumulation in the Organism of Bromide of Potassium.

PMID- 29835090
TI  - Iodides for Scrofulous Children.

PMID- 29835092
TI  - Darwinism on the Stage.

PMID- 29835091
TI  - Communicability of Cerebrospinal Meningitis.

PMID- 29835094
TI  - Renal Lesions.

PMID- 29835093
TI  - New Drugs, Appliances, and Things Medical: Dahl's Pure Milk.

PMID- 29835096
TI  - Among the Pines at Bournemouth.

PMID- 29835095
TI  - Absinthe.

PMID- 29835097
TI  - The Proposed Registration of Nurses.

PMID- 29835098
TI  - Hospital Abuse.

PMID- 29835099
TI  - Notes and News.

PMID- 29835100
TI  - Fruit.

PMID- 29835102
TI  - Treatment of Anaemia by Enemata of Defibrinated Blood.

PMID- 29835101
TI  - Charity's Financial Outlook.

PMID- 29835103
TI  - Physiological Candles: The Moral Fruits of Darwinism.

PMID- 29835104
TI  - Everybody's Page.

PMID- 29835105
TI  - The Nursing Supplement.

PMID- 29835106
TI  - Tonsil Slitting.

PMID- 29835108
TI  - Some Unpleasant Truths about Food and Luxuries.

PMID- 29835107
TI  - The Poplar Hospital.

PMID- 29835109
TI  - Notes and News.

PMID- 29835110
TI  - Treatment of Dysentery.

PMID- 29835111
TI  - The Hyderabad Commission on the Action of Chloroform.

PMID- 29835112
TI  - Light.

PMID- 29835113
TI  - Use of Tobacco.

PMID- 29835114
TI  - A Few Old Simples.

PMID- 29835115
TI  - Leprosy and Leper Houses.

PMID- 29835116
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29835117
TI  - Leprosy.

PMID- 29835118
TI  - Physiological Candles: "Then" and "Now".

PMID- 29835120
TI  - Miss Cobbe's Doctors.

PMID- 29835119
TI  - Cremation and Urn-Burial.

PMID- 29835121
TI  - Everybody's Page.

PMID- 29835122
TI  - Wounds of the Brain.

PMID- 29835123
TI  - The Nursing Supplement.

PMID- 29835124
TI  - Annotations.

PMID- 29835125
TI  - Thick Darkness.

PMID- 29835126
TI  - Annotations.

PMID- 29835127
TI  - The Oppression of the Medical Practitioner.

PMID- 29835128
TI  - Everybody's Page.

PMID- 29835130
TI  - Hypnotism.

PMID- 29835129
TI  - The Recent Hospital Dispute.

PMID- 29835131
TI  - A Word for Daudet.

PMID- 29835132
TI  - Professional Pressure.

PMID- 29835133
TI  - Enteric Fever in India.

PMID- 29835134
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29835135
TI  - Notes and News.

PMID- 29835136
TI  - The Registration of Midwives and Nurses: Important Decision of the General
      Council of Medical Education and Registration.

PMID- 29835138
TI  - The Nursing Supplement.

PMID- 29835137
TI  - Treatment of Diphtheria.

PMID- 29835139
TI  - Meat Diet.

PMID- 29835140
TI  - The Emigrant's Hospital at Ward Island.

PMID- 29835141
TI  - Minor Operations.

PMID- 29835142
TI  - Registration of Midwives and Nurses.

PMID- 29835143
TI  - Physiological Candles.

PMID- 29835144
TI  - Surgical Cases.

PMID- 29835145
TI  - Scarlet Fever in a Family of Five Children.

PMID- 29835146
TI  - Injuries from Electricity.

PMID- 29835147
TI  - The Proposed Registration of Nurses.

PMID- 29835148
TI  - Everybody's Page.

PMID- 29835150
TI  - Chronic Suppurative Pyelitis.

PMID- 29835149
TI  - Christmas "Outward and Visible".

PMID- 29835151
TI  - Epidemics and Ambulances.

PMID- 29835152
TI  - Old Cures for Hydrophobia.

PMID- 29835153
TI  - The Babe of Bethlehem.

PMID- 29835154
TI  - Fish as Food.

PMID- 29835155
TI  - Cycling in Its Relation to Health.

PMID- 29835156
TI  - Annotations.

PMID- 29835157
TI  - Influenza.

PMID- 29835158
TI  - Prevention of Cholera.

PMID- 29835159
TI  - A Hospital of All the Virtues.

PMID- 29835160
TI  - Cottage Hospital Ward Walls.

PMID- 29835161
TI  - Hay Fever.

PMID- 29835162
TI  - Mr. Besant's Latest Morality.

PMID- 29835163
TI  - The Nursing Supplement.

PMID- 29835164
TI  - Notes and News.

PMID- 29835165
TI  - Colotomy.

PMID- 29835166
TI  - The History and Capabilities of Herbal Simples: I. Introductory and Historical.

PMID- 29835167
TI  - St. Luke's Hospital for the Insane.

PMID- 29835168
TI  - Notes from Scandinavia.

PMID- 29835169
TI  - Clergyman's Sore Throat.

PMID- 29835171
TI  - Winter Cough.

PMID- 29835170
TI  - The Effect of the Entrance of Air into the Circulation.

PMID- 29835172
TI  - A Novelty in Disinfectants.

PMID- 29835173
TI  - Influenza.

PMID- 29835175
TI  - Trephining for Cerebral Tumour.

PMID- 29835174
TI  - Gifts to Christ.

PMID- 29835176
TI  - Knee-Joint Disease.

PMID- 29835177
TI  - Do Working Men Think?

PMID- 29835178
TI  - Everybody's Page.

PMID- 29835179
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29835180
TI  - Destitute Workmen's Aid Society.

PMID- 29835181
TI  - Notes and News.

PMID- 29835183
TI  - Hepatic Abscess.

PMID- 29835182
TI  - Annotations.

PMID- 29835184
TI  - Medical and Common Morality.

PMID- 29835185
TI  - The Abuse of Hospitals.

PMID- 29835186
TI  - Rhinitis.

PMID- 29835187
TI  - St. Luke's Hospital for the Insane.

PMID- 29835188
TI  - Pauperism in London.-II.

PMID- 29835189
TI  - The Hospital Sunday Fund and Institution for the Incurables.

PMID- 29835191
TI  - Calendrier de Sante, 1890.

PMID- 29835190
TI  - Hysterical Amaurosis.

PMID- 29835193
TI  - The Nursing Supplement.

PMID- 29835192
TI  - Incompatibles.

PMID- 29835194
TI  - Antipyrin.

PMID- 29835195
TI  - Accumulation of Arsenic in Spongy Bone.

PMID- 29835196
TI  - Treatment of Goitre by Iodine.

PMID- 29835197
TI  - Everybody's Page.

PMID- 29835198
TI  - The Nursing Supplement.

PMID- 29835199
TI  - An Infantile Complication.

PMID- 29835200
TI  - Diabetes in Childhood.

PMID- 29835201
TI  - Notes and News.

PMID- 29835202
TI  - Great and Enduring Deeds.

PMID- 29835203
TI  - Cancer of the Tongue.

PMID- 29835205
TI  - Treatment of Malarial Fever.

PMID- 29835204
TI  - Nerves and Epidemics.

PMID- 29835206
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29835207
TI  - Ophthalmia Neonatorum.

PMID- 29835208
TI  - Pauperism in London.

PMID- 29835209
TI  - Charity Lotteries.

PMID- 29835210
TI  - Popular Pastimes as Aids to Hospital Funds.

PMID- 29835211
TI  - Tetanus a Communicable Disease.

PMID- 29835212
TI  - Knowing Christ.

PMID- 29835213
TI  - The History and Capabilities of Herbal Simples: III. The Wood-Anemone, Angelica,
      Aniseed.

PMID- 29835214
TI  - Antisepsis.

PMID- 29835216
TI  - Biliary Calculi and Olive Oil.

PMID- 29835215
TI  - Annotations.

PMID- 29835217
TI  - The Proposed Registration of Nurses.

PMID- 29835218
TI  - A Vade Mecum for New Year's Givers.

PMID- 29835219
TI  - Aortic Aneurysm.

PMID- 29835220
TI  - More Voyages in Vacation.-II.

PMID- 29835221
TI  - Monotonous Diet.

PMID- 29835222
TI  - Albuminuria.

PMID- 29835223
TI  - Hypnotism.

PMID- 29835224
TI  - The Saturday Fund and St. John's Hospital.

PMID- 29835225
TI  - Obstructed Breathing from Anaethesia.

PMID- 29835226
TI  - Malingering.

PMID- 29835227
TI  - The Dignity of Work.

PMID- 29835228
TI  - Colour-Blindness.

PMID- 29835230
TI  - Variations of Symptoms from the Type.

PMID- 29835229
TI  - The Nursing Supplement.

PMID- 29835231
TI  - Notes and News.

PMID- 29835232
TI  - Treatment of Ague.

PMID- 29835234
TI  - Microbes.

PMID- 29835233
TI  - Life Seeds and Disinfection.

PMID- 29835236
TI  - The Cyprus Society: Hospital Work.

PMID- 29835235
TI  - Second Report of the Hyderabad Chloroform Commission.

PMID- 29835238
TI  - Annotations.

PMID- 29835237
TI  - Popular Pastimes as Aids to Hospital Funds.

PMID- 29835240
TI  - February.

PMID- 29835239
TI  - Everybody's Page.

PMID- 29835241
TI  - Diagnosis of Sickness in the Street.

PMID- 29835242
TI  - In Self-Defence.

PMID- 29835243
TI  - The Infancy of Christ.

PMID- 29835244
TI  - Ovariotomy and Listerism.

PMID- 29835245
TI  - The Nursing Supplement.

PMID- 29835246
TI  - Notes and News.

PMID- 29835247
TI  - The Third-Class Carriage.

PMID- 29835248
TI  - Everybody's Page.

PMID- 29835250
TI  - Robert Browning's Views of Life and Death.

PMID- 29835249
TI  - Foetal Malaria.

PMID- 29835251
TI  - Popular Pastimes as Aids to Hospital Funds: Demonstrations.

PMID- 29835252
TI  - Hospital Out-Patient Reform and Provident Dispensaries.

PMID- 29835253
TI  - Cancer.

PMID- 29835254
TI  - Food for Invalids.

PMID- 29835255
TI  - The Hospital Saturday Fund Awards.

PMID- 29835256
TI  - Annotations.

PMID- 29835257
TI  - Treatment of Carbuncle and Boils.

PMID- 29835258
TI  - The Extension of the Pension Fund.

PMID- 29835259
TI  - Cause of Typhoid Fever.

PMID- 29835260
TI  - Cottage Nurses and Their Training: An Abstract of Miss Broadwood's Paper.

PMID- 29835261
TI  - The Richmond Union Infirmary.

PMID- 29835263
TI  - Intestinal Strangulation.

PMID- 29835262
TI  - Pernicious Anaemia.

PMID- 29835265
TI  - Notes and News.

PMID- 29835264
TI  - Village Charities: II. Occasional Gifts.

PMID- 29835266
TI  - Epidemics past and Present.

PMID- 29835267
TI  - A Visit to a Training School for the Deaf: From a Travelling Correspondent.

PMID- 29835268
TI  - Transplantation of Rabbits' Conjunctiva to the Human Eye.

PMID- 29835269
TI  - Phthisis.

PMID- 29835271
TI  - Treatment of Disease by Electricity.

PMID- 29835270
TI  - Latent Gout.

PMID- 29835273
TI  - Annotations.

PMID- 29835272
TI  - "Hugh Woods, M.D.," and the Newspapers.

PMID- 29835274
TI  - Adulteration of Drugs.

PMID- 29835275
TI  - Operative Treatment of Dislocated Shoulder.

PMID- 29835276
TI  - Pathology of Chorea.

PMID- 29835277
TI  - Everybody's Page.

PMID- 29835278
TI  - The Nursing Supplement.

PMID- 29835279
TI  - Lady Dufferin's Fund.

PMID- 29835281
TI  - Syphillis.

PMID- 29835280
TI  - Man's Wants.

PMID- 29835283
TI  - Influenza Personally Conducted.

PMID- 29835282
TI  - Medicine and Socialism.

PMID- 29835284
TI  - Freedom.

PMID- 29835285
TI  - Winter Climate of the Nile.

PMID- 29835286
TI  - Annotations.

PMID- 29835287
TI  - The New Antiseptic, "Periodate Crystals Weavers".

PMID- 29835288
TI  - Alum Injection for Dysentery.

PMID- 29835289
TI  - Croup.

PMID- 29835291
TI  - A New Symptom.

PMID- 29835290
TI  - Haemorrhoids.

PMID- 29835292
TI  - March.

PMID- 29835293
TI  - Saccharin.

PMID- 29835295
TI  - Hypnotism Medically Considered.

PMID- 29835294
TI  - Goitre.

PMID- 29835296
TI  - Food and Force.

PMID- 29835297
TI  - Insects in Drugs.

PMID- 29835299
TI  - The Use of Antimony.

PMID- 29835298
TI  - Notes and News.

PMID- 29835300
TI  - Everybody's Page.

PMID- 29835301
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29835302
TI  - Earlswood as It Is.

PMID- 29835303
TI  - Infants' Food.

PMID- 29835304
TI  - The "Diphtheria House" at Zurich.

PMID- 29835305
TI  - The Nursing Supplement.

PMID- 29835306
TI  - The Ice Treatment.

PMID- 29835307
TI  - Vertigo.

PMID- 29835309
TI  - Novel Use of Mercury.

PMID- 29835308
TI  - Ought Members of the Active Medical Staffs to Sit upon Hospital Boards?

PMID- 29835310
TI  - Diseases of the Chest.

PMID- 29835311
TI  - The Town Dweller.

PMID- 29835312
TI  - Hydrophobia.

PMID- 29835313
TI  - Cornwall as a Winter Resort.

PMID- 29835314
TI  - Ought Members of the Active Medical Staff to Sit upon Hospital Boards?

PMID- 29835315
TI  - The Temporary Ligature.

PMID- 29835316
TI  - Notes and News.

PMID- 29835317
TI  - The Moral Basis of Private Property.-I.

PMID- 29835318
TI  - Elixers and Inoculations.

PMID- 29835319
TI  - The Nursing Supplement.

PMID- 29835320
TI  - Everybody's Page.

PMID- 29835321
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29835323
TI  - The Surgical Aspect of Hepatic Abscess.

PMID- 29835322
TI  - Sulphonal.

PMID- 29835324
TI  - Cocaine.

PMID- 29835325
TI  - Annotations.

PMID- 29835327
TI  - Puerperal Fevers.

PMID- 29835326
TI  - Milk for Infants.

PMID- 29835328
TI  - Diphtheretic Paralysis.

PMID- 29835329
TI  - Perfection.

PMID- 29835331
TI  - A Rare Event.

PMID- 29835330
TI  - The Hospital for the Insane.

PMID- 29835332
TI  - "Hugh Woods, M.D.," and the Newspapers.

PMID- 29835333
TI  - The History and Capabilities of Herbal Simples: V. The Common Arum, Asparagus,
      and Balm.

PMID- 29835334
TI  - Milk Poisoning.

PMID- 29835335
TI  - False Croup.

PMID- 29835336
TI  - Tracheotomy in Diphtheria.

PMID- 29835337
TI  - Unsatisfied.

PMID- 29835338
TI  - Is Vaccination a Fraud?

PMID- 29835339
TI  - Village Charities: I. Hard and Fast Rules of Distribution.

PMID- 29835340
TI  - Subjects of Social Welfare.

PMID- 29835341
TI  - A More Excellent Way.

PMID- 29835343
TI  - Meat Diet.

PMID- 29835342
TI  - New Drugs, Applances, and Things Medical.

PMID- 29835344
TI  - The Christian Origin of Hospitals.

PMID- 29835345
TI  - Everybody's Page.

PMID- 29835346
TI  - Mental Blindness.

PMID- 29835347
TI  - Silk as a Dressing.

PMID- 29835349
TI  - Chats at St. Ampelio.

PMID- 29835348
TI  - Acetanilide.

PMID- 29835350
TI  - A Plea for the Disappointed.

PMID- 29835351
TI  - Compression of the Thorax for Relieving the Pain of Pleurisy.

PMID- 29835353
TI  - Cure of Leprosy.

PMID- 29835352
TI  - The Nursing Supplement.

PMID- 29835354
TI  - Annotations.

PMID- 29835355
TI  - Ralph Ellison's Opportunity.

PMID- 29835356
TI  - The History and Capabilities of Herbal Simples: IV. The Apple.

PMID- 29835357
TI  - Injury to the Phrenic Nerve.

PMID- 29835358
TI  - A Kirmes at Buffalo.

PMID- 29835359
TI  - The Temperature in Influenza.

PMID- 29835360
TI  - Eczema.

PMID- 29835361
TI  - The History and Capabilities of Herbal Simples: XXXI.-The Elder.

PMID- 29835362
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29835363
TI  - Gelsemium Sempervirens.

PMID- 29835364
TI  - Neuritis of the Peripheral Nerves. - II.

PMID- 29835366
TI  - Everybody's Page.

PMID- 29835365
TI  - Noodles and Newspapers.

PMID- 29835367
TI  - Diabetic Coma.

PMID- 29835368
TI  - Annotations.

PMID- 29835369
TI  - The Hospital Nursing Supplement.

PMID- 29835370
TI  - Racial Science and Modern Politics.

PMID- 29835372
TI  - Notes and News.

PMID- 29835371
TI  - Putting the House in Order.

PMID- 29835373
TI  - The Dulness of Domestic Service.

PMID- 29835374
TI  - Progress in Medicine.

PMID- 29835376
TI  - Construction Notes.

PMID- 29835375
TI  - The Causes and Treatment of Ununited Fracture.

PMID- 29835377
TI  - Sewage in Scotch Lochs.

PMID- 29835378
TI  - Notes and News.

PMID- 29835379
TI  - Sixty Thousand Pounds for the London Hospitals.

PMID- 29835381
TI  - Progress in Laryngology.

PMID- 29835380
TI  - The Diagnosis of Aneurism.

PMID- 29835382
TI  - Health in the Schoolroom.

PMID- 29835383
TI  - New Appliances and Things Medical.

PMID- 29835385
TI  - The Metropolitan Hospital Sunday Fund, 1895.

PMID- 29835384
TI  - Progress in Rhinology.

PMID- 29835387
TI  - The Hospital Nursing Supplement.

PMID- 29835386
TI  - The Story of the Insane from Year to Year.

PMID- 29835388
TI  - The Stock Exchange and the Hospitals.

PMID- 29835389
TI  - Annotations.

PMID- 29835390
TI  - Morbid Growths.

PMID- 29835391
TI  - The Hospital Nursing Supplement.

PMID- 29835392
TI  - School Board Certificates.

PMID- 29835393
TI  - Down with the Butcher.

PMID- 29835394
TI  - The Story of the Insane from Year to Year.

PMID- 29835395
TI  - Education in Anthropology.

PMID- 29835396
TI  - Annotations.

PMID- 29835397
TI  - On the Differential Diagnosis of Popliteal Swellings.

PMID- 29835399
TI  - New Appliances and Things Medical.

PMID- 29835398
TI  - Anaemia, Leukaemia, and Lymphadenoma.

PMID- 29835400
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29835401
TI  - General Pathology.

PMID- 29835402
TI  - The Proper Business of the Coroner.

PMID- 29835403
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29835404
TI  - Notes and News.

PMID- 29835405
TI  - The Hospital Nursing Supplement.

PMID- 29835406
TI  - The Fallacies of Crude Statistics.

PMID- 29835407
TI  - The Study of Man in the British Association.

PMID- 29835408
TI  - Progress in Laryngology.

PMID- 29835409
TI  - The Examinations of the Future.

PMID- 29835410
TI  - Construction Notes.

PMID- 29835411
TI  - Early Marriages: Royal and Otherwise.

PMID- 29835413
TI  - Practical Departments.

PMID- 29835412
TI  - The Treatment of Patients after Abdominal Operations.

PMID- 29835414
TI  - Notes and News.

PMID- 29835415
TI  - New Appliances and Things Medical.

PMID- 29835416
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29835417
TI  - The Story of the Insane from Year to Year.

PMID- 29835418
TI  - Progress in Surgery.

PMID- 29835420
TI  - Annotations.

PMID- 29835419
TI  - The Sir Andrew Clark Memorial.

PMID- 29835422
TI  - Around the Hospitals.

PMID- 29835421
TI  - Progress in Medicine.

PMID- 29835424
TI  - Progress in Otology.

PMID- 29835423
TI  - Sleep and Its Disorders.-I.

PMID- 29835426
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29835425
TI  - Restrictions in the Use of Unproved Remedies.

PMID- 29835428
TI  - Notes and News.

PMID- 29835427
TI  - Administration of Anaesthetics.-II.

PMID- 29835430
TI  - The Hospital Nursing Supplement.

PMID- 29835429
TI  - The Anti-Vivisection Societies and the Hospitals.

PMID- 29835432
TI  - General Surgery.

PMID- 29835431
TI  - Dr. Waldo and the Salvation Army.

PMID- 29835433
TI  - Typhoid Fever.

PMID- 29835434
TI  - New Appliances and Things Medical.

PMID- 29835435
TI  - Practical Departments.

PMID- 29835436
TI  - Street Noises.

PMID- 29835438
TI  - Hospital Meetings.

PMID- 29835437
TI  - Climates of the past.

PMID- 29835439
TI  - Annotations.

PMID- 29835440
TI  - Helpers or Rivals? The Nurse Question.

PMID- 29835442
TI  - Notes and News.

PMID- 29835441
TI  - Hospital Meetings.

PMID- 29835444
TI  - Physical Treatment in Heart Disease.

PMID- 29835443
TI  - Death Certificates.

PMID- 29835446
TI  - New Appliances and Things Medical.

PMID- 29835447
TI  - The Clinical Society.

PMID- 29835449
TI  - The British Army as a Fighting Force.

PMID- 29835448
TI  - Progress in Medicine.

PMID- 29835450
TI  - Carbohydrate Starvation in Typhoid Fever.

PMID- 29835452
TI  - Annotations.

PMID- 29835451
TI  - The Treatment of Fractures of the Patella.

PMID- 29835453
TI  - The Hospital Nursing Supplement.

PMID- 29835454
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Latent Squint
      (Heterophoria).

PMID- 29835455
TI  - Construction Notes.

PMID- 29835457
TI  - The Hospital Nursing Supplement.

PMID- 29835456
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Squint.

PMID- 29835458
TI  - The Three Congresses: Their Lessons for Medicine.

PMID- 29835459
TI  - Annotations.

PMID- 29835460
TI  - Progress in Laryngology.

PMID- 29835461
TI  - Hospital and Asylum Construction.

PMID- 29835462
TI  - Dr. J. S. Billings.

PMID- 29835463
TI  - The Physiology of OEdema.

PMID- 29835465
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29835464
TI  - The Schott Treatment for Heart Disease.

PMID- 29835466
TI  - Notes and News.

PMID- 29835467
TI  - Practical Departments.

PMID- 29835468
TI  - Medicine and Pauperism in Country Districts.

PMID- 29835469
TI  - Hospital Meetings.

PMID- 29835470
TI  - Hospital Committees and Hospital Secretaries.

PMID- 29835471
TI  - Construction Notes.

PMID- 29835472
TI  - Adulterated Boots.

PMID- 29835473
TI  - Surgery of the Nerves.

PMID- 29835474
TI  - New Appliances and Things Medical.

PMID- 29835475
TI  - Movable Kidney.

PMID- 29835476
TI  - The Hospital Nursing Supplement.

PMID- 29835477
TI  - The Story of the Insane from Year to Year.

PMID- 29835478
TI  - The Relation between Haemic and Organic Cardiac Murmurs.

PMID- 29835480
TI  - Annus Medicus, 1895.

PMID- 29835479
TI  - Diseases of the Pancreas.

PMID- 29835482
TI  - Diseases of the Lungs and Pleurae.

PMID- 29835481
TI  - Annotations.

PMID- 29835483
TI  - Notes and News.

PMID- 29835484
TI  - Penology.

PMID- 29835486
TI  - Infantile Diarrhoea and Artificial Feeding.

PMID- 29835485
TI  - Annotations.

PMID- 29835487
TI  - Diseases of the Stomach.

PMID- 29835488
TI  - Diseases of the Nervous System.

PMID- 29835489
TI  - Leg versus Arm Vaccination.

PMID- 29835490
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Latent Squint.

PMID- 29835493
TI  - Notes and News.

PMID- 29835492
TI  - New Appliances and Things Medical.

PMID- 29835494
TI  - The Hospital Nursing Supplement.

PMID- 29835495
TI  - The Ethics of Operations.

PMID- 29835496
TI  - Hospital Meetings.

PMID- 29835497
TI  - Self-Help and Charitable Aid.

PMID- 29835499
TI  - New Appliances and Things Medical.

PMID- 29835498
TI  - Construction Notes.

PMID- 29835500
TI  - The Surgery of the Chest.

PMID- 29835501
TI  - The Place of Research in Education.

PMID- 29835502
TI  - Annotations.

PMID- 29835503
TI  - Hospital Secretaries and Their Salaries.

PMID- 29835504
TI  - Latency of Infection.

PMID- 29835505
TI  - Hospital Construction.

PMID- 29835506
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Squint.

PMID- 29835508
TI  - Notes and News.

PMID- 29835507
TI  - The Schott Treatment for Heart Disease.

PMID- 29835510
TI  - Diseases of the Upper Air Passages.

PMID- 29835509
TI  - Infective Diseases.

PMID- 29835511
TI  - The Hospital Nursing Supplement.

PMID- 29835512
TI  - The Throat Hospital, Golden Square.

PMID- 29835513
TI  - The Hospital Nursing Supplement.

PMID- 29835514
TI  - Diseases of the Stomach.

PMID- 29835515
TI  - The Treatment of Patients after Abdominal Operations.

PMID- 29835516
TI  - The Hospital: A Medical Journal.

PMID- 29835517
TI  - Surgery of the Nerves.

PMID- 29835518
TI  - Pharynx.

PMID- 29835520
TI  - Brain Surgery.

PMID- 29835519
TI  - Notes and News.

PMID- 29835522
TI  - New Appliances and Things Medical.

PMID- 29835521
TI  - The Criminal Type.

PMID- 29835524
TI  - Hospital Festivals, Meetings, &c.

PMID- 29835523
TI  - Hospital Expenditure.-The Commissariat.-I.

PMID- 29835525
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29835526
TI  - Argonine and Argentamine.

PMID- 29835527
TI  - Construction Notes.

PMID- 29835528
TI  - Practical Departments.

PMID- 29835529
TI  - Annotations.

PMID- 29835530
TI  - The Charity Organisation Society.

PMID- 29835531
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Squint.

PMID- 29835532
TI  - Doctors versus Drink.

PMID- 29835533
TI  - Progress in Medicine.

PMID- 29835534
TI  - The Epileptic Colony at Chalfont St. Peter.

PMID- 29835535
TI  - Notes and News.

PMID- 29835536
TI  - The Vindication of Water.

PMID- 29835537
TI  - The Hospital Nursing Supplement.

PMID- 29835539
TI  - The Rotunda Hospital, Dublin.

PMID- 29835538
TI  - Annotations.

PMID- 29835540
TI  - The Holloway Sanatorium.

PMID- 29835541
TI  - Hospital Construction.

PMID- 29835542
TI  - The General Medical Council.

PMID- 29835543
TI  - Progress in Surgery.

PMID- 29835544
TI  - Hospital Meetings.

PMID- 29835546
TI  - Annotations.

PMID- 29835545
TI  - Some Effects of Tight Lacing on Certain of the Abdominal Contents.

PMID- 29835547
TI  - A Forgotten Medical Hero.

PMID- 29835548
TI  - A Stage in the Evolution of Medicine.

PMID- 29835550
TI  - Notes and News.

PMID- 29835549
TI  - New Appliances and Things Medical.

PMID- 29835551
TI  - Ischio-Rectal Abscess and Fistula.

PMID- 29835552
TI  - Hunger as a Test of Poverty.

PMID- 29835553
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29835554
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29835555
TI  - Progress in Surgery.

PMID- 29835556
TI  - The Diagnosis of Aneurism.

PMID- 29835558
TI  - Winter Quarters.

PMID- 29835557
TI  - The Hospital Nursing Supplement.

PMID- 29835560
TI  - The Hospital Nursing Supplement.

PMID- 29835559
TI  - Progress in Otology.

PMID- 29835561
TI  - The Factors of National Health.

PMID- 29835562
TI  - The Story of the Insane from Year to Year.

PMID- 29835563
TI  - Progress in Surgery.

PMID- 29835564
TI  - Dyspepsia and Consumption: II. The Forms of Dyspepsia.

PMID- 29835565
TI  - Progress in Medicine.

PMID- 29835566
TI  - Hospital Meetings.

PMID- 29835567
TI  - Annotations.

PMID- 29835568
TI  - Trimmer's Cottage Hospital, Farnham.

PMID- 29835569
TI  - Hospital Construction.

PMID- 29835571
TI  - The Out-Patient System and Its Abuse.

PMID- 29835570
TI  - Acute Necrosis.

PMID- 29835572
TI  - The Ophthalmology of the Poets.

PMID- 29835573
TI  - Practical Departments.

PMID- 29835574
TI  - Notes and News.

PMID- 29835575
TI  - New Appliances and Things Medical.

PMID- 29835576
TI  - Sunshine on the South Coast.

PMID- 29835577
TI  - Notes and News.

PMID- 29835579
TI  - Hotel-Dieu Du Creusot.

PMID- 29835578
TI  - Practical Departments.

PMID- 29835580
TI  - New Appliances and Things Medical.

PMID- 29835581
TI  - Some Observations on Typhoid Fever.

PMID- 29835583
TI  - A Hospital for Lepers in Iceland.

PMID- 29835582
TI  - Three Cases of Diphtheria Treated with Ruffer's Curative Serum.

PMID- 29835584
TI  - Annotations.

PMID- 29835585
TI  - The Multiplication of Vaccines.

PMID- 29835587
TI  - The Andrew Clark Memorial.

PMID- 29835586
TI  - Diseases of the Lungs and Pleurae.

PMID- 29835588
TI  - In Praise of High Feeding.

PMID- 29835589
TI  - Renal Medicine.

PMID- 29835590
TI  - The Treatment of Aneurism.

PMID- 29835591
TI  - The Hospital Nursing Supplement.

PMID- 29835592
TI  - A New Hospital for Valparaiso.

PMID- 29835593
TI  - Philanthropists among the London Poor.

PMID- 29835594
TI  - Progress in Surgery.

PMID- 29835595
TI  - New Appliances and Things Medical.

PMID- 29835596
TI  - Laundry and Sanitary Exhibition at the Agricultural Hall.

PMID- 29835597
TI  - The Financial Condition of the North-Eastern Hospital for Children.

PMID- 29835598
TI  - Progress in Obstetrics.

PMID- 29835599
TI  - Hospital Expenditure. - The Commissariat.

PMID- 29835600
TI  - Practical Departments.

PMID- 29835601
TI  - Practical Anthropology.

PMID- 29835602
TI  - Hospital Meetings.

PMID- 29835603
TI  - Ischio-Rectal Abscess and Fistula.

PMID- 29835604
TI  - Tubcrculosis in Cattle.

PMID- 29835605
TI  - Notes and News.

PMID- 29835606
TI  - The Water Drinker Three Centuries Ago.

PMID- 29835607
TI  - Annotations.

PMID- 29835608
TI  - Progress in Otology.

PMID- 29835609
TI  - The Hospital Nursing Supplement.

PMID- 29835610
TI  - Hospital Festivals Meetings, &c.

PMID- 29835611
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29835612
TI  - Practical Departments.

PMID- 29835613
TI  - Annotations.

PMID- 29835614
TI  - Some Unutilized Resources of Civilisation.

PMID- 29835615
TI  - The Fate of Colour-Blind Sailors.

PMID- 29835617
TI  - Fifteen Thousand Pounds for the Charities.

PMID- 29835616
TI  - Around the Hospitals.

PMID- 29835619
TI  - The Hospital Nursing Supplement.

PMID- 29835618
TI  - An Appeal to Appealers.

PMID- 29835620
TI  - The Treatment of Abscess in Pott's Disease.

PMID- 29835621
TI  - Progress in Rhinology.

PMID- 29835623
TI  - New Appliances and Things Medical.

PMID- 29835622
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29835624
TI  - Construction Notes.

PMID- 29835625
TI  - Administration of Anaesthetics.

PMID- 29835627
TI  - Progress in Medicine.

PMID- 29835626
TI  - Notes and News.

PMID- 29835628
TI  - Hospital Expenditure: The Commissariat.

PMID- 29835629
TI  - Surgery of the Liver and Gall Bladder.

PMID- 29835630
TI  - Lunacy and Pauperism.

PMID- 29835631
TI  - The Hospital Nursing Supplement.

PMID- 29835632
TI  - On the Treatment of Femoral Hernia: Reducible Femoral Hernia.

PMID- 29835633
TI  - Diseases of the Nervous System.

PMID- 29835634
TI  - Annotations.

PMID- 29835635
TI  - Notes and News.

PMID- 29835636
TI  - Vaccination Officers.

PMID- 29835637
TI  - The Presidency of the Royal College of Physicians.

PMID- 29835638
TI  - Diseases of the Intestines.

PMID- 29835640
TI  - The Old and the New Vitalism.

PMID- 29835639
TI  - Dyspepsia and Consumption: III. Treatment.

PMID- 29835642
TI  - Hospital Meetings.

PMID- 29835641
TI  - New Appliances and Things Medical.

PMID- 29835644
TI  - Practical Points.

PMID- 29835643
TI  - Graves' Disease.

PMID- 29835646
TI  - Hospital Expenditure. - The Commissariat.

PMID- 29835645
TI  - The Treatment of Abscess in Pott's Disease.

PMID- 29835648
TI  - Hospital Festivals, Meetings, &c.

PMID- 29835647
TI  - Diseases of the Digestive Organs.

PMID- 29835650
TI  - Some Practical Aspects of Bovine Tuberculosis.

PMID- 29835649
TI  - Electricity and the Processes of Life.

PMID- 29835651
TI  - Notes and News.

PMID- 29835652
TI  - Construction Notes.

PMID- 29835654
TI  - Editor's Letter-Box.

PMID- 29835653
TI  - Annotations.

PMID- 29835655
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Squint.

PMID- 29835656
TI  - Progress in Obstetrics.

PMID- 29835657
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29835658
TI  - The Hospital Nursing Supplement.

PMID- 29835659
TI  - A Social Reform Club.

PMID- 29835660
TI  - Cottage Hospital, Wood Green.

PMID- 29835661
TI  - Physical Treatment in Heart Disease.

PMID- 29835662
TI  - New Appliances and Things Medical.

PMID- 29835663
TI  - The Localisation of Tumours of the Spinal Cord Amenable to Surgical Treatment.

PMID- 29835664
TI  - Hospital Sunday Fund.

PMID- 29835665
TI  - Progress in Medicine.

PMID- 29835666
TI  - The Treatment of Criminals.

PMID- 29835667
TI  - A Prophylactic Clothes Philosophy.

PMID- 29835668
TI  - Notes and News.

PMID- 29835669
TI  - The New Radiant Energy.

PMID- 29835671
TI  - Progress in Surgery.

PMID- 29835670
TI  - The Hospital Nursing Supplement.

PMID- 29835672
TI  - Annotations.

PMID- 29835674
TI  - Charity or Business?

PMID- 29835673
TI  - The Treatment of Aneurism.

PMID- 29835675
TI  - New Appliances and Things Medical.

PMID- 29835676
TI  - Is Crime Decreasing?

PMID- 29835677
TI  - The Vaccination Commission.

PMID- 29835678
TI  - Progress in Medicine.

PMID- 29835679
TI  - Hospital Expenditure: The Commissariat.

PMID- 29835680
TI  - Annotations.

PMID- 29835681
TI  - Construction Notes.

PMID- 29835683
TI  - Progress in Surgery.

PMID- 29835682
TI  - The Hospital Nursing Supplement.

PMID- 29835684
TI  - Hospital Meetings.

PMID- 29835685
TI  - The Leucocyte in Disease.

PMID- 29835687
TI  - Notes and News.

PMID- 29835689
TI  - Municipal Dwellings for Working Men.

PMID- 29835688
TI  - Clinical Recollections.

PMID- 29835691
TI  - The Discontent in the British Medical Association.

PMID- 29835690
TI  - Hospital Expenditure: The Commissariat.

PMID- 29835693
TI  - The Hospital Nursing Supplement.

PMID- 29835692
TI  - An Appreciation of "The Hospital."

PMID- 29835694
TI  - On Aneurisms.

PMID- 29835695
TI  - Hospital Construction.

PMID- 29835696
TI  - The Care of the Sick in Prisons.

PMID- 29835697
TI  - Hospital Meetings.

PMID- 29835698
TI  - The Coming of Easter.

PMID- 29835699
TI  - Notes and News.

PMID- 29835700
TI  - The Treatment of Acquired Flat-Foot.

PMID- 29835701
TI  - Annotations.

PMID- 29835702
TI  - Periscope of Dermatology.

PMID- 29835703
TI  - Progress in Surgery.

PMID- 29835704
TI  - New Appliances and Things Medical.

PMID- 29835705
TI  - The Hospital Nursing Supplement.

PMID- 29835706
TI  - Progress in Medicine.

PMID- 29835708
TI  - The Dead Weight of the Sick.

PMID- 29835707
TI  - Practical Departments.

PMID- 29835710
TI  - The Demoralising Tendency of Reformatory and Industrial Schools.

PMID- 29835709
TI  - Annotations.

PMID- 29835711
TI  - New Appliances and Things Medical.

PMID- 29835712
TI  - Construction Notes.

PMID- 29835713
TI  - The Colliery Disaster.

PMID- 29835714
TI  - Notes and News.

PMID- 29835715
TI  - Haemorrhoids: Causes and Symptoms.

PMID- 29835716
TI  - Progress in Surgery.

PMID- 29835717
TI  - Physical Treatment in Heart Disease.

PMID- 29835718
TI  - Anthropology at the Universities.

PMID- 29835719
TI  - Clinical Recollections.

PMID- 29835720
TI  - Trimmer's Cottage Hospital, Farnham.

PMID- 29835721
TI  - The Salaries of Hospital Secretaries.

PMID- 29835723
TI  - New Appliances and Things Medical.

PMID- 29835722
TI  - Boston Hospital Tent Service.

PMID- 29835724
TI  - The Hospital Nursing Supplement.

PMID- 29835725
TI  - Rectal Surgery.

PMID- 29835727
TI  - Surgery of the Spine.

PMID- 29835726
TI  - Surgical Fees at Charity Hospitals.

PMID- 29835729
TI  - The "Gorham" Bed.

PMID- 29835728
TI  - Sleep and Its Disorders.-II.

PMID- 29835731
TI  - The Physiology of Fighting.

PMID- 29835732
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Squint.

PMID- 29835733
TI  - Diseases of the Lungs.

PMID- 29835734
TI  - Notes and News.

PMID- 29835736
TI  - The Wastrels of Modern Cities.

PMID- 29835735
TI  - Annotations.

PMID- 29835737
TI  - The Story of the Insane from Year to Year.

PMID- 29835738
TI  - Annotations.

PMID- 29835739
TI  - New Appliances and Things Medical.

PMID- 29835741
TI  - Abdominal Surgery.

PMID- 29835740
TI  - The Treatment of Fractures of the Patella.

PMID- 29835742
TI  - Discretionary Bequests.

PMID- 29835743
TI  - Dyspepsia and Consumption: I. Dyspepsia as a Cause and Complication.

PMID- 29835744
TI  - The Influence of Mind upon Body.

PMID- 29835745
TI  - Notes and News.

PMID- 29835747
TI  - Alcohol and Longevity.

PMID- 29835748
TI  - The United States Army Medical Department.

PMID- 29835749
TI  - The Ophthalmology of the Poets.

PMID- 29835750
TI  - The Hospital Nursing Supplement.

PMID- 29835751
TI  - Orthopaedic Surgery.

PMID- 29835752
TI  - Coroners and Practitioners.

PMID- 29835754
TI  - British Balneological and Climatological Society.

PMID- 29835753
TI  - New Hospital for Burton-On-Trent.

PMID- 29835756
TI  - The Mechanism of Motion.

PMID- 29835755
TI  - The Hospital Nursing Supplement.

PMID- 29835757
TI  - Practical Points.

PMID- 29835758
TI  - Hospital Construction.

PMID- 29835760
TI  - Around the Hospitals.

PMID- 29835759
TI  - Notes and News.

PMID- 29835762
TI  - The Limits of Medical Competition.

PMID- 29835761
TI  - Annotations.

PMID- 29835765
TI  - Progress in Medicine.

PMID- 29835763
TI  - Haemorrhoids: Causes and Symptoms.

PMID- 29835766
TI  - Progress in Surgery.

PMID- 29835768
TI  - Is a Small-Pox Hospital a Nuisance?

PMID- 29835767
TI  - The Use of Sedatives in Phthisis.

PMID- 29835769
TI  - Construction Notes.

PMID- 29835770
TI  - Hospital Meetings.

PMID- 29835771
TI  - Practical Departments.

PMID- 29835772
TI  - Genito-Urinary Surgery.

PMID- 29835773
TI  - Annotations.

PMID- 29835774
TI  - The "Coromandel": The Hospital Ship for the Ashanti Expedition.

PMID- 29835775
TI  - The Hospital.-Christmas Appeal Supplement.

PMID- 29835776
TI  - Around the Hospitals.

PMID- 29835778
TI  - Hospital Expenditure.-The Commissariat.

PMID- 29835777
TI  - The Case for Vaccination.-From a Pathological Standpoint.

PMID- 29835779
TI  - Heredity and the Race.

PMID- 29835780
TI  - General Surgery.

PMID- 29835782
TI  - Carrying-Chair.

PMID- 29835781
TI  - The Treatment of Epilepsy.

PMID- 29835783
TI  - New Appliances and Things Medical.

PMID- 29835784
TI  - General Pathology.

PMID- 29835785
TI  - Notes and News.

PMID- 29835786
TI  - Can the Treatment of the Insane Be Improved?

PMID- 29835788
TI  - The Dispensaries of North-West India.

PMID- 29835787
TI  - The Hospital Nursing Supplement.

PMID- 29835789
TI  - Medical Offenders.

PMID- 29835790
TI  - Modern Sociology.

PMID- 29835791
TI  - Professional Secrecy.

PMID- 29835792
TI  - Annotations.

PMID- 29835793
TI  - The Story of the Insane from Year to Year.

PMID- 29835794
TI  - The Prevention of Shock.

PMID- 29835795
TI  - New Appliances and Things Medical.

PMID- 29835796
TI  - Absence of Hydrochloric Acid in Cancer of the Stomach.

PMID- 29835797
TI  - Some Clinical Aspects of Granular Kidney.

PMID- 29835798
TI  - Progress in Medicine.

PMID- 29835799
TI  - The Classification of the Insane.

PMID- 29835800
TI  - Therapeutical Notes.

PMID- 29835801
TI  - "The Hospital" Nursing Mirror.

PMID- 29835802
TI  - Registration of Midwives.

PMID- 29835804
TI  - Progress in Surgery.

PMID- 29835803
TI  - Hospital Meetings, &c.

PMID- 29835805
TI  - Notes and News.

PMID- 29835806
TI  - Plymouth Isolation Hospital.

PMID- 29835807
TI  - Progress in Surgery.

PMID- 29835808
TI  - Progress in Medicine.

PMID- 29835809
TI  - Dislocations of the Finger.

PMID- 29835810
TI  - Notes on the Use of Bacteriological Methods of Diagnosis in Private Practice.
      III.

PMID- 29835812
TI  - The Water Supply of East London.

PMID- 29835811
TI  - Lunacy in Scotland.

PMID- 29835813
TI  - Annotations.

PMID- 29835814
TI  - Stamps and Hospitals.

PMID- 29835816
TI  - New Appliances and Things Medical.

PMID- 29835815
TI  - "The Hospital" Nursing Mirror.

PMID- 29835817
TI  - Modern Sociology.

PMID- 29835818
TI  - An Organised Boycott.

PMID- 29835819
TI  - The Physician as Pessimist.

PMID- 29835821
TI  - Early and Free Operation for Breast Cancer.

PMID- 29835820
TI  - On Chronic Joint Diseases as Seen in Medical Out-Patients.-II.

PMID- 29835822
TI  - Hospital Meetings, &c.

PMID- 29835823
TI  - Experimentation and Hospitals.

PMID- 29835825
TI  - Annotations.

PMID- 29835824
TI  - Modern Sociology.

PMID- 29835826
TI  - Notes and News.

PMID- 29835827
TI  - Midwifery and General Practice.

PMID- 29835829
TI  - Phosphorus Poisoning.

PMID- 29835828
TI  - A Warning in Regard to the Reduction of Dislocation of the Humerus.

PMID- 29835831
TI  - Pancreatic Cysts.

PMID- 29835830
TI  - Architecture and Sanitation.

PMID- 29835832
TI  - Therapeutical Notes.

PMID- 29835833
TI  - "The Hospital" Nursing Mirror.

PMID- 29835835
TI  - The Government Stamp on Proprietary Medicines.

PMID- 29835834
TI  - New Appliances and Things Medical.

PMID- 29835836
TI  - Women and the Medical Societies.

PMID- 29835837
TI  - Green Vision in a Tabetic Patient.

PMID- 29835838
TI  - Progress in Surgery.

PMID- 29835839
TI  - The Open Air Treatment of Phthisis.

PMID- 29835840
TI  - The "Times" on Lead Poisoning.

PMID- 29835841
TI  - The Bacteriological Diagnosis of Diphtheria.

PMID- 29835843
TI  - The Story of the Insane from Year to Year.

PMID- 29835842
TI  - Progress in Medicine.

PMID- 29835844
TI  - Annotations.

PMID- 29835845
TI  - Progress in Surgery.

PMID- 29835846
TI  - Modern Sociology.

PMID- 29835847
TI  - Christian Scientists.

PMID- 29835848
TI  - Notes.

PMID- 29835849
TI  - The Hospital System in Ireland.

PMID- 29835850
TI  - "The Hospital" Nursing Mirror.

PMID- 29835851
TI  - New Appliances and Things Medical.

PMID- 29835852
TI  - Gas Stoves in Bed-Rooms.

PMID- 29835853
TI  - Progress in Medicine.

PMID- 29835854
TI  - The Value of General Treatment in Diseases of Throat, Nose, and Ear.

PMID- 29835855
TI  - Hospital Meetings, &c.

PMID- 29835856
TI  - Modern Sociology.

PMID- 29835857
TI  - Annotations.

PMID- 29835858
TI  - After San Juan.

PMID- 29835859
TI  - Notes and News.

PMID- 29835860
TI  - Paraldehyde in the Treatment of Asthma.

PMID- 29835861
TI  - Some Clinical Aspects of Granular Kidney.

PMID- 29835862
TI  - "The Hospital" Nursing Mirror.

PMID- 29835864
TI  - The Government and Vaccination.

PMID- 29835863
TI  - Nottingham Children's Hospital.

PMID- 29835866
TI  - New Appliances and Things Medical.

PMID- 29835865
TI  - Removal of the Uterus for "Unavoidable Haemorrhage".

PMID- 29835868
TI  - "The Hospital" Nursing Mirror.

PMID- 29835867
TI  - Hospital Stamps and Out-Patients.

PMID- 29835870
TI  - Annotations.

PMID- 29835869
TI  - Fleas as Carriers of Infection.

PMID- 29835871
TI  - Notes and News.

PMID- 29835872
TI  - Institutional Amenities.

PMID- 29835874
TI  - British Laryngological, Rhinological, and Otological Association.

PMID- 29835873
TI  - Tropical Diseases.

PMID- 29835876
TI  - The Future of Midwifery Practice.

PMID- 29835875
TI  - Progress in Surgery.

PMID- 29835877
TI  - OEdema of the Upper Extremity Following Injuries to the Olecranon Bursae.

PMID- 29835878
TI  - New Appliances and Things Medical.

PMID- 29835879
TI  - Helouan.

PMID- 29835880
TI  - Progress in Medicine.

PMID- 29835881
TI  - Hospital Meetings, &c.

PMID- 29835882
TI  - Annotations.

PMID- 29835883
TI  - Exercise and Over-Exercise.

PMID- 29835884
TI  - The Title of "Physician".

PMID- 29835885
TI  - Bromoform.

PMID- 29835886
TI  - A Preliminary Incision.

PMID- 29835887
TI  - The Postage of Periodicals.

PMID- 29835888
TI  - The Prince of Wales's Fund.

PMID- 29835889
TI  - Progress in Ophthalmology.

PMID- 29835890
TI  - Notes and News.

PMID- 29835891
TI  - "The Hospital" Nursing Mirror.

PMID- 29835892
TI  - Hospital Meetings, &c.

PMID- 29835893
TI  - Belladonna in Broncho-Pneumonia in Children.

PMID- 29835894
TI  - New Appliances and Things Medical.

PMID- 29835895
TI  - Modern Sociology.

PMID- 29835896
TI  - Progress in Medicine.

PMID- 29835897
TI  - Children's Hospital, Nottingham.

PMID- 29835898
TI  - Practical Points.

PMID- 29835899
TI  - A Grumble about Anaesthetics.

PMID- 29835900
TI  - The Typhoid Bacillus and Its Associates.

PMID- 29835901
TI  - Symphysiotomy.

PMID- 29835902
TI  - Therapeutical Notes.

PMID- 29835903
TI  - Hospital Meetings, &c.

PMID- 29835904
TI  - Annotations.

PMID- 29835906
TI  - "The Hospital" Nursing Mirror.

PMID- 29835905
TI  - Diphtheria Antitoxin in General Practice.

PMID- 29835907
TI  - Experimentation and Hospitals.

PMID- 29835908
TI  - Progress in Medicine.

PMID- 29835910
TI  - Typhoid Infection.

PMID- 29835909
TI  - Progress in Surgery.

PMID- 29835911
TI  - The Workmen's Compensation Act.

PMID- 29835912
TI  - Notes and News.

PMID- 29835914
TI  - Progress in Ophthalmology.

PMID- 29835913
TI  - On Chronic Joint Diseases as Seen in Medical Out-Patients.-I.

PMID- 29835916
TI  - The London Government Bill.

PMID- 29835915
TI  - Vanishing Tumours.

PMID- 29835917
TI  - New Appliances and Things Medical.

PMID- 29835918
TI  - Progress in State Medicine.

PMID- 29835919
TI  - Coxa Vara Treated by Division of the Femur below the Trochanters.

PMID- 29835920
TI  - Hospital Construction.

PMID- 29835921
TI  - Modern Sociology.

PMID- 29835922
TI  - Progress in Medicine.

PMID- 29835923
TI  - Urinary Tuberculosis.

PMID- 29835924
TI  - "The Hospital" Nursing Mirror.

PMID- 29835925
TI  - Late Injections of Diphtheria Antitoxin.

PMID- 29835926
TI  - Dual Consciousness and Allied States.

PMID- 29835928
TI  - Notes and News.

PMID- 29835927
TI  - Progress in Surgery.

PMID- 29835930
TI  - Dangerous Illuminants.

PMID- 29835929
TI  - Nottingham Children's Hospital.

PMID- 29835931
TI  - Army Convalescent Homes.

PMID- 29835932
TI  - Hospital Meetings, &c.

PMID- 29835933
TI  - Our National Almshouses.

PMID- 29835934
TI  - Ectopic Gestation.

PMID- 29835935
TI  - Annotations.

PMID- 29835936
TI  - Nitrous Oxide and Oxygen.

PMID- 29835938
TI  - Progress in Surgery.

PMID- 29835937
TI  - Plague and Quarantine.

PMID- 29835939
TI  - Annotations.

PMID- 29835940
TI  - The Cases of Collins and Whitmarsh.

PMID- 29835941
TI  - "The Hospital" Nursing Mirror.

PMID- 29835942
TI  - New Appliances and Things Medical.

PMID- 29835944
TI  - Typhoid Fever in Relation to Privies, Water-Closets, and Rateable Value.

PMID- 29835943
TI  - Institutional Amenities.

PMID- 29835946
TI  - Hospital Saturday Fund.

PMID- 29835945
TI  - The Treatment of Ulcers of the Cornea.

PMID- 29835947
TI  - Modern Sociology.

PMID- 29835948
TI  - Periscope of Dermatology.

PMID- 29835949
TI  - Contused Wounds of the Abdomen.

PMID- 29835950
TI  - Infantile Diarrhoea.

PMID- 29835951
TI  - Notes and News.

PMID- 29835952
TI  - The Search for Specifics.

PMID- 29835953
TI  - Modern Sociology.

PMID- 29835954
TI  - The Operative Treatment of Cancer of the Breast.

PMID- 29835955
TI  - Progress in Surgery.

PMID- 29835956
TI  - "The Hospital" Nursing Mirror.

PMID- 29835957
TI  - Annotations.

PMID- 29835958
TI  - A Professor on Tour.

PMID- 29835959
TI  - New Appliances and Things Medical.

PMID- 29835960
TI  - Notes and News.

PMID- 29835961
TI  - Progress in Medicine.

PMID- 29835962
TI  - Ill-Behaved Patients.

PMID- 29835963
TI  - Unqualified Assistants.

PMID- 29835964
TI  - Chronic Discharges from the Ear and Their Treatment.

PMID- 29835965
TI  - Hospital Meetings, &c.

PMID- 29835966
TI  - The General Medical Council.

PMID- 29835967
TI  - Puerperal Fever: Its Definition and Its Notification.

PMID- 29835968
TI  - The League of Mercy.

PMID- 29835969
TI  - New Appliances and Things Medical.

PMID- 29835970
TI  - Progress in Surgery.

PMID- 29835971
TI  - The Extirpation of Aneurysms.

PMID- 29835972
TI  - Hospital Meetings, &c.

PMID- 29835973
TI  - "The Hospital" Nursing Mirror.

PMID- 29835974
TI  - Exploratory Incisions.

PMID- 29835975
TI  - Modern Sociology.

PMID- 29835976
TI  - Progress in State Medicine.

PMID- 29835977
TI  - Therapeutical Notes.

PMID- 29835978
TI  - The Prince of Wales's Hospital Fund for London.

PMID- 29835979
TI  - The Provident Dispensary.

PMID- 29835980
TI  - National Hysteria.

PMID- 29835981
TI  - Annotations.

PMID- 29835982
TI  - Notes and News.

PMID- 29835984
TI  - Operations on Typhoid Ulcers.

PMID- 29835983
TI  - Progress in Medicine.

PMID- 29835985
TI  - Some Clinical Aspects of Granular Kidney.

PMID- 29835986
TI  - New Appliances and Things Medical.

PMID- 29835987
TI  - Hospital Administration.

PMID- 29835989
TI  - Winter Health Resorts.

PMID- 29835988
TI  - On Retention of Urine and Its Treatment.

PMID- 29835991
TI  - "The Hospital" Nursing Mirror.

PMID- 29835990
TI  - The Opening Session.

PMID- 29835992
TI  - Hospital Construction.

PMID- 29835993
TI  - Progress in Orthopaedics.

PMID- 29835994
TI  - Progress in Medicine.

PMID- 29835995
TI  - Annotations.

PMID- 29835997
TI  - The National Society for Aid to the Sick and Wounded in War.

PMID- 29835996
TI  - Professor Virchow.

PMID- 29835999
TI  - Queen's Jubilee Hospital.

PMID- 29835998
TI  - Education-General and Technical.

PMID- 29836001
TI  - "The Hospital" Nursing Mirror.

PMID- 29836000
TI  - Notes and News.

PMID- 29836002
TI  - Children's Hospital, Nottingham.

PMID- 29836003
TI  - Therapeutical Notes.

PMID- 29836005
TI  - Children's Hospital, Nottingham.

PMID- 29836004
TI  - Grave Injuries to the Abdominal Walls.

PMID- 29836007
TI  - Progress in Surgery.

PMID- 29836006
TI  - Children's Hospital, Nottingham.

PMID- 29836009
TI  - Progress in Medicine.

PMID- 29836008
TI  - New Appliances and Things Medical.

PMID- 29836010
TI  - Hospital Meetings, &c.

PMID- 29836011
TI  - Children's Hospital, Nottingham.

PMID- 29836013
TI  - Annotations.

PMID- 29836012
TI  - Epidemic Cerebrospinal Meningitis.

PMID- 29836014
TI  - Superheated Dry Air.

PMID- 29836015
TI  - Tuberculosis in Children.

PMID- 29836016
TI  - Local Infiltration Analgesia.

PMID- 29836017
TI  - The Measurement of Arterial Blood Pressure.

PMID- 29836019
TI  - Flies and Infection.

PMID- 29836018
TI  - Progress in Surgery.

PMID- 29836021
TI  - The Red Cross Society.

PMID- 29836020
TI  - What Is Eczema?

PMID- 29836022
TI  - Modern Sociology.

PMID- 29836023
TI  - Malignant Disease of the Vocal Cords.

PMID- 29836024
TI  - Royal Medical and Chirurgical Society.

PMID- 29836025
TI  - The Etiology of "Return" Cases of Scarlet Fever.

PMID- 29836026
TI  - New Appliances and Things Medical.

PMID- 29836027
TI  - Annotations.

PMID- 29836028
TI  - Institutional Amenities.

PMID- 29836029
TI  - Periscope of Dermatology.

PMID- 29836030
TI  - Severe Abdominal Injuries without External Wound.

PMID- 29836031
TI  - Bromide of Strontium in the Treatment of Epilepsy.

PMID- 29836032
TI  - The Plague.

PMID- 29836033
TI  - Notes and News.

PMID- 29836035
TI  - "The Hospital" Nursing Mirror.

PMID- 29836034
TI  - Notes on the Use of Bacteriological Methods of Diagnosis in Private Practice.-IV.

PMID- 29836036
TI  - Progress in Orthopaedics.

PMID- 29836037
TI  - The Red Cross in the Soudan.

PMID- 29836038
TI  - Legal Restrictions on Practice by Quacks.

PMID- 29836039
TI  - Prince of Wales's Hospital Fund for London.

PMID- 29836040
TI  - Progress in Medicine.

PMID- 29836041
TI  - Progress in Surgery.

PMID- 29836042
TI  - The Purity of Milk.

PMID- 29836043
TI  - Notes and News.

PMID- 29836044
TI  - Hospital Meetings, &c.

PMID- 29836045
TI  - Operation in Cancer of the Uterus.

PMID- 29836046
TI  - Schools and Diphtheria.

PMID- 29836047
TI  - Artificial Lighting for Public Institutions.

PMID- 29836048
TI  - Chronic Discharges from the Ear and Their Treatment.

PMID- 29836049
TI  - Addenbrooke's Hospital.

PMID- 29836050
TI  - Annotations.

PMID- 29836052
TI  - Therapeutical Notes.

PMID- 29836051
TI  - Dispensing by Nurses.

PMID- 29836053
TI  - The General Medical Council.

PMID- 29836054
TI  - "The Hospital" Nursing Mirror.

PMID- 29836055
TI  - A New Urinary Disinfectant.

PMID- 29836056
TI  - "The Hospital" Nursing Mirror.

PMID- 29836057
TI  - Antiseptics at Guy's Hospital.

PMID- 29836058
TI  - Progress in Surgery.

PMID- 29836060
TI  - The Obstetrical Society.

PMID- 29836059
TI  - The Treatment of Strumous Glands in the Neck.

PMID- 29836062
TI  - New Appliances and Things Medical.

PMID- 29836061
TI  - Notes and News.

PMID- 29836064
TI  - Annotations.

PMID- 29836063
TI  - Modern Sociology.

PMID- 29836066
TI  - Progress in Medicine.

PMID- 29836065
TI  - Ventilating the Nose.

PMID- 29836067
TI  - Cottage Hospital Expenditure.

PMID- 29836068
TI  - Unreliable Medical Certificates.

PMID- 29836070
TI  - The Harveian Oration.

PMID- 29836069
TI  - The Swansea Hospital Dispute.

PMID- 29836071
TI  - Progress in Orthopaedics.

PMID- 29836072
TI  - Verification of the Cause of Death.

PMID- 29836074
TI  - Chlorosis: Its Complications and Treatment.

PMID- 29836073
TI  - Institutional Amenities.

PMID- 29836075
TI  - The Prince of Wales's Hospital Fund.

PMID- 29836076
TI  - Progress in Surgery.

PMID- 29836077
TI  - The Care of Semi-Lunatics.

PMID- 29836079
TI  - Progress in State Medicine.

PMID- 29836078
TI  - The Diagnosis of Malignant Endocarditis.

PMID- 29836080
TI  - Constipation.

PMID- 29836081
TI  - Organised Charity Abroad.

PMID- 29836083
TI  - Annotations.

PMID- 29836082
TI  - New Appliances and Things Medical.

PMID- 29836084
TI  - Notes and News.

PMID- 29836085
TI  - "The Hospital" Nursing Mirror.

PMID- 29836086
TI  - The Heart and Its Difficulties.

PMID- 29836087
TI  - The Story of the Insane from Year to Year.

PMID- 29836088
TI  - Royal Medical and Chirurgical Society.

PMID- 29836089
TI  - Progress in Medicine.

PMID- 29836090
TI  - Medicine in Government.

PMID- 29836091
TI  - Therapeutical Notes.

PMID- 29836093
TI  - Annotations.

PMID- 29836092
TI  - The Old Year.

PMID- 29836095
TI  - A New Midwives Bill.

PMID- 29836094
TI  - The Victoria Hospital for Children.

PMID- 29836097
TI  - Notes and News.

PMID- 29836096
TI  - Progress in Medicine.

PMID- 29836098
TI  - The Story of the Insane from Year to Year.

PMID- 29836099
TI  - New Appliances and Things Medical.

PMID- 29836100
TI  - Organised Charity Abroad.

PMID- 29836101
TI  - The Need of Idiot Asylums.

PMID- 29836103
TI  - Modern Sociology.

PMID- 29836102
TI  - Progress in Surgery.

PMID- 29836105
TI  - "The Hospital" Nursing Mirror.

PMID- 29836104
TI  - Prince of Wales's Hospital Fund for London.

PMID- 29836107
TI  - The Employment of Midwives by Medical Men.

PMID- 29836106
TI  - Hospital Construction.

PMID- 29836108
TI  - Progress in Medicine.

PMID- 29836109
TI  - New Appliances and Things Medical.

PMID- 29836111
TI  - Modern Sociology.

PMID- 29836110
TI  - The Treatment of Typhoid Fever.

PMID- 29836112
TI  - Periscope of Dermatology.

PMID- 29836113
TI  - Cerebro-Spinal Fluid Escaping from the Nose.

PMID- 29836115
TI  - The Volunteer Medical Department.

PMID- 29836114
TI  - Institutional Amenities.

PMID- 29836116
TI  - "The Hospital" Nursing Mirror.

PMID- 29836117
TI  - Progress in Surgery.

PMID- 29836119
TI  - The Jenner Society.

PMID- 29836118
TI  - St. Bartholomew's Hospital.

PMID- 29836121
TI  - Notes and News.

PMID- 29836120
TI  - The Treatment of Acute Intestinal Obstruction.

PMID- 29836122
TI  - Annotations.

PMID- 29836123
TI  - The Use of Rabbit Bone in Surgery.

PMID- 29836124
TI  - The Story of the Insane from Year to Year.

PMID- 29836125
TI  - The Crusade against Consumption.

PMID- 29836126
TI  - Resection of Ribs in Apical Phthisis.

PMID- 29836127
TI  - Progress in Medicine.

PMID- 29836128
TI  - Periscope of Dermatology.

PMID- 29836129
TI  - Annotations.

PMID- 29836130
TI  - The Decentralisation of Great Cities.

PMID- 29836131
TI  - Modern Sociology.

PMID- 29836132
TI  - Progress in Surgery.

PMID- 29836133
TI  - Diagnosis or "Proof."

PMID- 29836135
TI  - The Royal College of Surgeons.

PMID- 29836134
TI  - The Treatment of Uterine Myomata.

PMID- 29836136
TI  - "The Hospital" Nursing Mirror.

PMID- 29836138
TI  - Notes and News.

PMID- 29836137
TI  - Artificial Lighting for Public Institutions.

PMID- 29836139
TI  - Dispensing by Nurses.

PMID- 29836140
TI  - The Physique of Schoolboys.

PMID- 29836141
TI  - Pregnancy with Persistent Hymen.

PMID- 29836142
TI  - New Appliances and Things Medical.

PMID- 29836143
TI  - Hospital Meetings, &c.

PMID- 29836144
TI  - Modern Sociology.

PMID- 29836145
TI  - Children's Christmas Parties.

PMID- 29836146
TI  - Notes and News.

PMID- 29836147
TI  - Progress in Surgery.

PMID- 29836148
TI  - The New Neurology.

PMID- 29836149
TI  - Compulsory Medical Service.

PMID- 29836150
TI  - Removal of Lens for Extreme Myopia.

PMID- 29836151
TI  - The Liability of Hospital Trustees.

PMID- 29836152
TI  - The Children's Hospital at Nottingham.

PMID- 29836154
TI  - Progress in Medicine.

PMID- 29836153
TI  - "The Hospital" Nursing Mirror.

PMID- 29836155
TI  - The Relations of the General Committee and Medical Staff of a Hospital.

PMID- 29836156
TI  - Annotations.

PMID- 29836158
TI  - The Treatment of Aneurism.

PMID- 29836157
TI  - The Electric Bath for Chilblains.

PMID- 29836159
TI  - New Appliances and Things Medical.

PMID- 29836160
TI  - The Prince of Wales's Hospital Fund.

PMID- 29836162
TI  - Progress in Surgery.

PMID- 29836161
TI  - The Diagnosis of Malignant Endocarditis.

PMID- 29836163
TI  - Annotations.

PMID- 29836164
TI  - Therapeutical Notes.

PMID- 29836166
TI  - Hospital Meetings, &c.

PMID- 29836165
TI  - The Liabilities of Hospital Trustees.

PMID- 29836167
TI  - Surgery in Dublin.

PMID- 29836168
TI  - Organised Charity Abroad.

PMID- 29836169
TI  - Liberty and Tuberculosis.

PMID- 29836170
TI  - Medical Certificates Again.

PMID- 29836171
TI  - A Consulting Institution.

PMID- 29836172
TI  - Progress in Medicine.

PMID- 29836174
TI  - The Endowment of Research.

PMID- 29836173
TI  - On the Preparation for and After-Treatment of Abdominal Operations.

PMID- 29836176
TI  - What Is a Consultant's Fee?

PMID- 29836175
TI  - Modern Sociology.

PMID- 29836177
TI  - "The Hospital" Nursing Mirror.

PMID- 29836178
TI  - Professional Custom and Professional Caste.

PMID- 29836179
TI  - Notes and News.

PMID- 29836180
TI  - In Honour of Francis Joseph.

PMID- 29836182
TI  - Annotations.

PMID- 29836181
TI  - Hospital Housekeeping.

PMID- 29836183
TI  - On the Preparation for and After-Treatment of Abdominal Operations.

PMID- 29836184
TI  - An Object Lesson in Public Water Services.

PMID- 29836185
TI  - The Prevention of Short Leg in Hip Disease.

PMID- 29836186
TI  - Hospital Meetings, &c.

PMID- 29836187
TI  - "The Hospital" Nursing Mirror.

PMID- 29836188
TI  - Notes and News.

PMID- 29836189
TI  - Insanitary Areas and Rehousing.

PMID- 29836190
TI  - Progress in Medicine.

PMID- 29836191
TI  - Progress in Surgery.

PMID- 29836192
TI  - Hospital Construction.

PMID- 29836193
TI  - Obstetrical Society.

PMID- 29836195
TI  - Drains and Diphtheria.

PMID- 29836194
TI  - The Clinical Society.

PMID- 29836196
TI  - Commissions.

PMID- 29836197
TI  - New Appliances and Things Medical.

PMID- 29836199
TI  - Chloroform Administration in the Midlands.

PMID- 29836198
TI  - The Prince's Power for Good.

PMID- 29836200
TI  - Modern Sociology.

PMID- 29836201
TI  - The Story of the Middlesbrough Small-Pox Epidemic.

PMID- 29836202
TI  - The Liability of Hospital Trustees.

PMID- 29836203
TI  - Purulent Ophthalmia a Source of Gonococcus Joint Disease in Infants.

PMID- 29836204
TI  - Notes and News.

PMID- 29836205
TI  - New Appliances and Things Medical.

PMID- 29836206
TI  - Progress in Surgery.

PMID- 29836207
TI  - London Water Supply.

PMID- 29836208
TI  - Polymyositis.

PMID- 29836209
TI  - The Control of Tuberculosis.

PMID- 29836210
TI  - Nursery Aid Society and Medical Relief.

PMID- 29836211
TI  - "The Hospital" Nursing Mirror.

PMID- 29836213
TI  - The Localisation of Kidney Tuberculosis.

PMID- 29836212
TI  - The Story of the Insane from Year to Year.

PMID- 29836214
TI  - Annotations.

PMID- 29836215
TI  - Modern Sociology.

PMID- 29836216
TI  - Hospital Construction.

PMID- 29836217
TI  - Hospital Meetings, &c.

PMID- 29836218
TI  - Consumption and Overcrowding.

PMID- 29836219
TI  - Progress in Medicine.

PMID- 29836220
TI  - The Stereoscope.

PMID- 29836221
TI  - The Hospital.-Christmas Appeal Supplement.

PMID- 29836222
TI  - Annotations.

PMID- 29836223
TI  - Notes and News.

PMID- 29836224
TI  - Modern Sociology.

PMID- 29836225
TI  - Chronic Discharges from the Ear and Their Treatment.

PMID- 29836226
TI  - "The Hospital" Nursing Mirror.

PMID- 29836227
TI  - A Study in Nomenclature.

PMID- 29836229
TI  - Hospital Meetings, &c.

PMID- 29836228
TI  - The Peculiar People.

PMID- 29836231
TI  - The Union of Wounds.

PMID- 29836230
TI  - Pressure in the Treatment of Wounds.

PMID- 29836232
TI  - Progress in Surgery.

PMID- 29836233
TI  - Home Vaccination.

PMID- 29836234
TI  - Self Help for Hospitals and Their Patients.

PMID- 29836235
TI  - Progress in Medicine.

PMID- 29836236
TI  - New Appliances and Things Medical.

PMID- 29836237
TI  - Everybody's Page.

PMID- 29836238
TI  - An Ishmaelite.

PMID- 29836239
TI  - A Plea for the London Hospital.

PMID- 29836240
TI  - Constitution Building.

PMID- 29836242
TI  - Home Colonisation.

PMID- 29836241
TI  - Notes and News.

PMID- 29836243
TI  - Annotations: A Homoeopathic Earl-Something like a Secretary.-Hospital Patients
      and Stimulants.

PMID- 29836244
TI  - The Elberfeld System.

PMID- 29836246
TI  - The Nursing Supplement.

PMID- 29836245
TI  - Aids to Nursing.

PMID- 29836248
TI  - The Vinnicombe Bequest: A Narrative of Hospital Work and Hospital Wants.

PMID- 29836247
TI  - A Hard Case.

PMID- 29836249
TI  - Points for Preachers, Churchworkers, and Pressmen.

PMID- 29836250
TI  - Speakers and Speech.

PMID- 29836252
TI  - A Year's Work in the Hospitals and Medical Charities of London.

PMID- 29836251
TI  - The Nursing Supplement.

PMID- 29836253
TI  - Christianity and the Sick.

PMID- 29836254
TI  - Facts and Figures.

PMID- 29836255
TI  - An Ishmaelite.

PMID- 29836256
TI  - Annotations: The Extension of the Leeds Infirmary-Anti-Vaccination Tactics: The
      Borax Trick-Roses in the Rain.

PMID- 29836257
TI  - The Bones of the Upper Limb.

PMID- 29836258
TI  - The "Universal Review".

PMID- 29836259
TI  - Awards and Criticisms.

PMID- 29836260
TI  - Notes and News.

PMID- 29836261
TI  - The Waste of Brain Resources.

PMID- 29836262
TI  - Everybody's Page.

PMID- 29836263
TI  - Is a General Register for Nurses Desirable?

PMID- 29836265
TI  - The Bitter Cry of the General Practitioner.

PMID- 29836264
TI  - The Nursing Supplement.

PMID- 29836266
TI  - Popular Fallacies about Cancer.

PMID- 29836267
TI  - The Nursing Supplement.

PMID- 29836268
TI  - A Hard Case.

PMID- 29836269
TI  - Aids to Nursing.

PMID- 29836270
TI  - Round about the Asylums.-VI.

PMID- 29836272
TI  - Annotations: Sources of Small-Pox.-Calmer Weather at the Rotherham Hospital.-A
      Real University for London.

PMID- 29836271
TI  - The Bright Side of Hospital Life.-A Rejoinder.

PMID- 29836273
TI  - Patients' Contributions to Hospitals.

PMID- 29836274
TI  - Labourers' Wages and Labourers' Homes.

PMID- 29836276
TI  - Notes and News.

PMID- 29836275
TI  - An Ishmaelite.

PMID- 29836277
TI  - Everybody's Page.

PMID- 29836278
TI  - The British Home for Incurables.

PMID- 29836279
TI  - Watchman, What of the Night?

PMID- 29836280
TI  - A Governess Protests!

PMID- 29836281
TI  - The Sufferings of Christ.

PMID- 29836282
TI  - In and out among the Hospitals.

PMID- 29836283
TI  - Phlebotomy in Excelsis.

PMID- 29836285
TI  - The Paddington Fund for the Unemployed.

PMID- 29836284
TI  - Notes and News.

PMID- 29836287
TI  - Everybody's Page.

PMID- 29836286
TI  - An Ishmaelite.

PMID- 29836288
TI  - Hints for the Sick-Room.

PMID- 29836290
TI  - Opiates and Anaesthetics.

PMID- 29836289
TI  - The Hospitals Association and Patients' Contributions.

PMID- 29836291
TI  - Annotations: Profane Demonstrations by Friendly Societies.- Nurse Farming.

PMID- 29836292
TI  - A Word to M.Ps.

PMID- 29836293
TI  - The Nursing Supplement.

PMID- 29836294
TI  - The Uses of a Health Resort.

PMID- 29836295
TI  - Legislative Social Reforms.

PMID- 29836296
TI  - Physical Improvement and Technical Training.

PMID- 29836298
TI  - Annotations: Asylum Attendants.-Faults on Both Sides.-The Public Demands an
      Inquiry.

PMID- 29836297
TI  - Everybody's Page.

PMID- 29836300
TI  - The Doctor's Pulpit.

PMID- 29836299
TI  - Patients' Contributions to Hospitals.

PMID- 29836301
TI  - Free Rest for Hospital Nurses.

PMID- 29836302
TI  - An Ishmaelite.

PMID- 29836303
TI  - The Nursing Supplement.

PMID- 29836304
TI  - Notes and News.

PMID- 29836305
TI  - Labourers' Wages and Labourers' Homes.

PMID- 29836306
TI  - Comparative Expenditure of Hospitals.

PMID- 29836307
TI  - Annotations: A Medical Prodigy at Glasgow.-An Interesting Centenary at York.-Are
      Midwives Despised?

PMID- 29836308
TI  - Voluntary versus State-Supported Hospitals.

PMID- 29836309
TI  - An Ishmaelite.

PMID- 29836310
TI  - Physiology and Its Uses.

PMID- 29836311
TI  - Everybody's Page.

PMID- 29836312
TI  - Round about the Asylums.-IV.

PMID- 29836313
TI  - Out of the Depths.

PMID- 29836314
TI  - Nerve-Tides.

PMID- 29836315
TI  - Facts about the London Hospital.

PMID- 29836316
TI  - Notes and News.

PMID- 29836317
TI  - The Sufferings of Christ.

PMID- 29836318
TI  - The Nursing Supplement.

PMID- 29836319
TI  - The Obligations of Knowledge.

PMID- 29836320
TI  - Scotch Physicians and Surgeons: James Syme.

PMID- 29836321
TI  - Healthy Hospitals.

PMID- 29836322
TI  - An Ishmaelite.

PMID- 29836324
TI  - Bones and Backbones.

PMID- 29836323
TI  - Patients' Contributions to Hospitals.

PMID- 29836325
TI  - Constitution Building.

PMID- 29836326
TI  - Annotations: Will Workmen Give?-Can Workmen Pay?-Pasteurism and Hydrophobia.

PMID- 29836327
TI  - Everybody's Page.

PMID- 29836328
TI  - The Sufferings of Christ.

PMID- 29836329
TI  - Buried Alive!

PMID- 29836330
TI  - Notes and News.

PMID- 29836331
TI  - The Nursing Supplement.

PMID- 29836332
TI  - Everybody's Page.

PMID- 29836334
TI  - The Growth of Hospital Opinion.

PMID- 29836333
TI  - A Plea for the London Hospital.

PMID- 29836336
TI  - The Mildmay Cottage Hospital.

PMID- 29836335
TI  - The Nursing Supplement.

PMID- 29836337
TI  - Annotations: Sympathy and Congratulation.-The Care of Consumption.-The Case for
      Hanging.

PMID- 29836338
TI  - Hospitals and the Drama.

PMID- 29836339
TI  - Medicine Men of the World.

PMID- 29836340
TI  - Patients' Contributions to Hospitals.

PMID- 29836341
TI  - Tonics.

PMID- 29836342
TI  - Round about the Asylums. VII.

PMID- 29836343
TI  - Notes and News.

PMID- 29836344
TI  - Scotch Physicians and Surgeons.

PMID- 29836345
TI  - An Ishmalite.

PMID- 29836346
TI  - The Discovery of Natural Gifts.

PMID- 29836347
TI  - Vegetarianism.

PMID- 29836348
TI  - Notes and News.

PMID- 29836349
TI  - The Jaeger Revolution.

PMID- 29836350
TI  - An Ishmaelite.

PMID- 29836351
TI  - The Dangers of Celebrity.

PMID- 29836352
TI  - The Land of Golden Day.

PMID- 29836354
TI  - The Nursing Supplement.

PMID- 29836353
TI  - Scotch Physicians and Surgeons: James Syme.

PMID- 29836355
TI  - Round about the Asylums.-V.

PMID- 29836356
TI  - Comparative Expenditure in Hospitals.

PMID- 29836357
TI  - Constitution Building.

PMID- 29836359
TI  - The Sufferings of Christ.

PMID- 29836358
TI  - Vegetarianism.

PMID- 29836360
TI  - The New Great Northern Central Hospital.

PMID- 29836361
TI  - Annotations: Lying-In Hospitals.-Total Abstinence and Poor Relief.-Women and
      Faddists.

PMID- 29836363
TI  - Nurse-Training Schools and Registration.

PMID- 29836362
TI  - In and out among the Hospitals.

PMID- 29836364
TI  - Everybody's Page.

PMID- 29836365
TI  - Notes and News.

PMID- 29836366
TI  - St. Katherine's Hospital.

PMID- 29836367
TI  - The Choice of a Health Resort.

PMID- 29836368
TI  - Thunderstorms and Lightning Accidents, etc.

PMID- 29836369
TI  - The Hospitals Association and Patients' Contributions.

PMID- 29836370
TI  - Our First Hospital Saturday.

PMID- 29836371
TI  - Everybody's Page.

PMID- 29836372
TI  - Round about the Asylums.-X.

PMID- 29836373
TI  - The Needs of Bachelors.

PMID- 29836374
TI  - An Ishmaelite.

PMID- 29836375
TI  - The General Practitioner's Indictment of the Hospitals.

PMID- 29836376
TI  - Annotations: Summer Underclothing.-Wealth for Women, etc.

PMID- 29836377
TI  - Hints for the Sick-Room.

PMID- 29836379
TI  - The Nursing Supplement.

PMID- 29836378
TI  - Great Wit and Madness.

PMID- 29836381
TI  - Nerve-Storms.

PMID- 29836380
TI  - Phrenology: A Protest.

PMID- 29836382
TI  - The Nursing Mirror.

PMID- 29836383
TI  - An Ishmaelite: Father and Son.

PMID- 29836385
TI  - Everybody's Page.

PMID- 29836384
TI  - Notes and News.

PMID- 29836386
TI  - Supplement to the Hospital.

PMID- 29836387
TI  - Four Worlds.

PMID- 29836388
TI  - The Open-Door System.

PMID- 29836389
TI  - To "E. P. M."

PMID- 29836390
TI  - The Sufferings of Christ.

PMID- 29836391
TI  - London Hospitals and Metropolitan Members.

PMID- 29836393
TI  - Lady Dufferin's Fund.

PMID- 29836392
TI  - A Temple of Lucifer.

PMID- 29836395
TI  - Scotch Physicians and Surgeons: Sir Robert Christison.

PMID- 29836394
TI  - Aids to Nursing: Food and Feeding.

PMID- 29836397
TI  - Notes and News.

PMID- 29836396
TI  - Annotations: The Presidency of the College of Physicians.-Infectious Cases:
      Temporary or Permanent Hospitals.-Mr. Walter Besant's Craze about Women.

PMID- 29836398
TI  - The Leicester Provident Dispensary.

PMID- 29836400
TI  - Patients' Contributions to Hospitals.

PMID- 29836399
TI  - In and out among the Hospitals.

PMID- 29836402
TI  - The Nursing Supplement.

PMID- 29836401
TI  - An Ishmaelite.

PMID- 29836403
TI  - The Needs and Backbone of the Hospital System.

PMID- 29836404
TI  - Our Hospital System.

PMID- 29836405
TI  - Sailors and Anti-Scorbutics.

PMID- 29836406
TI  - Labourers' Wages and Labourers' Homes.

PMID- 29836407
TI  - Everybody's Page.

PMID- 29836408
TI  - Annotations: The Site of St. Mary's Hospital.-Cheap Houses for Ladies.-An
      Unsavoury Subject.

PMID- 29836409
TI  - Difficult Cases.

PMID- 29836410
TI  - Nurse-Training Schools and Registration.

PMID- 29836411
TI  - Army Recollections.

PMID- 29836412
TI  - The Dispenser's Column.

PMID- 29836413
TI  - Annotations: Paupers for Farmers.-Cottage Industries in Ireland.-The Progress of
      Self-Help among Workmen.

PMID- 29836415
TI  - Metropolitan Hospital Sunday Fund, 1888.

PMID- 29836414
TI  - Hints for the Sick-Room.

PMID- 29836416
TI  - The Nursing Supplement.

PMID- 29836417
TI  - Everybody's Page.

PMID- 29836418
TI  - Human Barometers.

PMID- 29836419
TI  - An Ishmaelite.

PMID- 29836420
TI  - New Remedies and Appliances.

PMID- 29836422
TI  - Lonely.

PMID- 29836421
TI  - Round about the Asylums-XI.

PMID- 29836423
TI  - Notes and News.

PMID- 29836424
TI  - The Medical Profession and Income Tax.

PMID- 29836425
TI  - Within the Wards.

PMID- 29836426
TI  - Malingering.

PMID- 29836427
TI  - A Homily for Hospital Sunday Reading.

PMID- 29836428
TI  - An Ishmalite.

PMID- 29836429
TI  - A Few Words about Our Hospitals.

PMID- 29836430
TI  - A Census of Hospital Workers.

PMID- 29836431
TI  - The Nursing Supplement.

PMID- 29836432
TI  - Bedrests-A Sad Though Simple Story.

PMID- 29836433
TI  - Notes and News.

PMID- 29836434
TI  - Patients' Contributions to Hospitals.

PMID- 29836436
TI  - Everybody's Page.

PMID- 29836435
TI  - Preachers and Subjects for Hospital Sunday.

PMID- 29836437
TI  - Children's Country Hospitals.

PMID- 29836438
TI  - A Fresh Start with the Summer.

PMID- 29836439
TI  - In and out among the Hospitals.

PMID- 29836441
TI  - Annotations.

PMID- 29836440
TI  - The Leicester Provident Dispensary.-A Rejoinder.

PMID- 29836442
TI  - Play.

PMID- 29836443
TI  - Dr. Bristowe on the Registration of Nurses.

PMID- 29836444
TI  - The Connexion between Out-Patients and Annual Subscriptions.

PMID- 29836445
TI  - Everybody's Page.

PMID- 29836446
TI  - Difficult Cases.

PMID- 29836447
TI  - Dr. Wendell Holmes and the Secret of the Universe.

PMID- 29836448
TI  - Within the Wards.

PMID- 29836449
TI  - Notes and News.

PMID- 29836450
TI  - The Surgery of the Past.

PMID- 29836452
TI  - Provident and Improvident Hospitals.

PMID- 29836451
TI  - The British Nurses' Association.

PMID- 29836453
TI  - The Dead Emperor.

PMID- 29836454
TI  - An Ishmaelite.

PMID- 29836455
TI  - Annotations: The Dorset County Asylum-The Massacre of the Innocents.-An Apostle
      of Long Life.

PMID- 29836456
TI  - The Crown Prince William and His Left Arm.

PMID- 29836457
TI  - The Nursing Supplement.

PMID- 29836459
TI  - New Remedies and Appliances.

PMID- 29836458
TI  - Hints for the Sick-Room: Leeches, Cupping, and Blisters.

PMID- 29836460
TI  - The Puddingless Patients.

PMID- 29836461
TI  - The Dispensers' Column.

PMID- 29836462
TI  - Annotations: The Decay of Family Feeling, etc.

PMID- 29836463
TI  - An Ishmaelite.

PMID- 29836464
TI  - A New Art.

PMID- 29836465
TI  - Frederick III., Emperor and King.

PMID- 29836467
TI  - The Human Skull.

PMID- 29836466
TI  - Round about the Asylums. VIII.

PMID- 29836469
TI  - The "Universal Review" and Our Critics.

PMID- 29836468
TI  - Notices and Reviews.

PMID- 29836470
TI  - Lines Written in Winchester Hospital.

PMID- 29836471
TI  - Patients' Contributions to Hospitals.

PMID- 29836472
TI  - Bolingbroke House, Wandsworth Common.

PMID- 29836473
TI  - Anonymous Slanderers and Working Men.

PMID- 29836474
TI  - Notes and News.

PMID- 29836475
TI  - A Day in Bed.

PMID- 29836476
TI  - The Nursing Supplement.

PMID- 29836477
TI  - Minor Aids to Medical Study.

PMID- 29836478
TI  - Everybody's Page.

PMID- 29836479
TI  - An Ishmaelite.

PMID- 29836480
TI  - The Bones of the Hand.

PMID- 29836481
TI  - Everybody's Page.

PMID- 29836482
TI  - A Splendid Special Hospital.

PMID- 29836483
TI  - The Nursing Supplement.

PMID- 29836484
TI  - Malingering.

PMID- 29836485
TI  - The Odium Medicum and Homoeopathy in America.

PMID- 29836486
TI  - In the Midst of Life.

PMID- 29836487
TI  - Maiming by Firearms, etc.

PMID- 29836488
TI  - A Defence of the Old Hospital System.

PMID- 29836490
TI  - Notes and News.

PMID- 29836489
TI  - The Science and Art of Housekeeping.

PMID- 29836491
TI  - Not Charity, Nurses, but Self-Help.

PMID- 29836492
TI  - Aids to Memory.

PMID- 29836493
TI  - Annotations: Pity the Poor Practitioner.-Child-Cheats.-The Insurance of Children.

PMID- 29836494
TI  - Voluntary Imbecility.

PMID- 29836495
TI  - Climate and Suicide.

PMID- 29836496
TI  - Hospital Finance and Economy.

PMID- 29836497
TI  - How to Grow Beautiful.

PMID- 29836498
TI  - Round about the Asylums.-XIII.

PMID- 29836499
TI  - Annotations: Ambulances Wanted.-The Weather Notwith-Standing.-The Value of a
      Little Medical Knowledge.

PMID- 29836500
TI  - The Nursing Supplement.

PMID- 29836501
TI  - Everybody's Page.

PMID- 29836502
TI  - A Medical Plan of Campaign.

PMID- 29836503
TI  - Notes and News.

PMID- 29836505
TI  - Swiss Small-Pox Statistics.

PMID- 29836504
TI  - An Ishmaelite.

PMID- 29836506
TI  - Hints for the Sick-Room.

PMID- 29836507
TI  - The Claims of Hospitals.

PMID- 29836508
TI  - An Ishmaelite.

PMID- 29836509
TI  - The Immediate Treatment of Accidents and Sudden Illness.

PMID- 29836510
TI  - Annotations: Ambulances Still Wanted.-The Money Value of a Live Man.-Poor John
      Aldcroft!

PMID- 29836512
TI  - A New Inquisition.

PMID- 29836511
TI  - Notes and News.

PMID- 29836513
TI  - Everybody's Page.

PMID- 29836514
TI  - The Nursing Supplement.

PMID- 29836515
TI  - "In Hot Haste," etc.

PMID- 29836516
TI  - Marriage-Or What?

PMID- 29836517
TI  - The Unemployed.

PMID- 29836518
TI  - Workmen's Payments to Sunderland Hospitals.

PMID- 29836519
TI  - Hospital Finance-A Disclaimer.

PMID- 29836520
TI  - A Question of Smoke.

PMID- 29836521
TI  - Annotations: The Celt and the Teuton.-Certain Knaves and Certain Fools.

PMID- 29836522
TI  - Woodhall.

PMID- 29836523
TI  - In and out among the Hospitals.

PMID- 29836524
TI  - Venus or AEsculapius?

PMID- 29836525
TI  - The Nursing Supplement.

PMID- 29836526
TI  - London Hospitals "the Pay System".

PMID- 29836527
TI  - General Practitioners and Paying Patients.

PMID- 29836528
TI  - An Ishmaelite.

PMID- 29836529
TI  - Everybody's Page.

PMID- 29836530
TI  - Notes and News.

PMID- 29836532
TI  - An Indian Woman's Tribute to Lady Dufferin.

PMID- 29836531
TI  - The Hospitals Association.

PMID- 29836533
TI  - A Medical Olive Branch.

PMID- 29836534
TI  - The Children's Convalescent Home at Great Yarmouth.

PMID- 29836535
TI  - The Seaside Season.

PMID- 29836536
TI  - A New Surgical Operation.

PMID- 29836538
TI  - Everybody's Page.

PMID- 29836537
TI  - An Ishmaelite.

PMID- 29836540
TI  - The Nursing Supplement.

PMID- 29836539
TI  - Round about the Asylums.-XII.

PMID- 29836541
TI  - Heat-Stroke.

PMID- 29836542
TI  - Annotations: The British Medical Association.-The Women's Jubilee Offering.

PMID- 29836543
TI  - Doctors and Patients.

PMID- 29836545
TI  - Notes and News.

PMID- 29836544
TI  - Fever and Cholera Precautions.

PMID- 29836546
TI  - Notes and News.

PMID- 29836547
TI  - Everybody's Page.

PMID- 29836548
TI  - Within the Wards.

PMID- 29836549
TI  - The Art of Embalming.

PMID- 29836550
TI  - Children and Crime.

PMID- 29836551
TI  - In and out among the Hospitals.

PMID- 29836553
TI  - Marriage and Morals.

PMID- 29836552
TI  - An Ishmaelite.

PMID- 29836554
TI  - Hints for the Sick-Room.

PMID- 29836555
TI  - The King of Causes of Disease.

PMID- 29836556
TI  - Operation.

PMID- 29836557
TI  - Annotations: The National Pension Fund and Its One Adverse Critic.-The Stable
      Door.-The Cancer Hospital at Brompton.

PMID- 29836559
TI  - The Nursing Supplement.

PMID- 29836558
TI  - The Claims of Hospitals.

PMID- 29836561
TI  - Voluntary Chaplains.

PMID- 29836560
TI  - Hints for the Sick-Room.

PMID- 29836562
TI  - Notes and News.

PMID- 29836563
TI  - The Nursing Supplement.

PMID- 29836565
TI  - Mental Depression.

PMID- 29836564
TI  - A Great Scottish Hospital.

PMID- 29836566
TI  - Portents and Epidemics.

PMID- 29836568
TI  - Everybody's Page.

PMID- 29836567
TI  - The Editor's Letter-Box.

PMID- 29836569
TI  - Voyages in Vacation. I.

PMID- 29836570
TI  - New Remedies and Appliances.

PMID- 29836571
TI  - The Bones of the Leg.

PMID- 29836572
TI  - Annotations: Brag or Benevolence?-A "Sweated" Lady.-Committee-Men and Business
      Contracts.

PMID- 29836574
TI  - The Nursing Supplement.

PMID- 29836573
TI  - An Ishmaelite.

PMID- 29836575
TI  - An "Unvarnished Tale."

PMID- 29836576
TI  - The Plea of the Patient.

PMID- 29836577
TI  - Medical Schools and Medical Students.

PMID- 29836579
TI  - A Garden Party at the Cancer Hospital.

PMID- 29836580
TI  - Annotations.

PMID- 29836578
TI  - Hints for the Sick-Room.

PMID- 29836581
TI  - Everybody's Page.

PMID- 29836583
TI  - Notes and News.

PMID- 29836582
TI  - Hospital Clothing and Bedding.

PMID- 29836584
TI  - The Student's Bitter Cry.

PMID- 29836585
TI  - A Hypochondriacal Patient's Song.

PMID- 29836587
TI  - The Discipline of Medical Schools.

PMID- 29836586
TI  - An Ishmaelite.

PMID- 29836588
TI  - Malingering under the Old Regime.

PMID- 29836589
TI  - The Doctor in the West-End Mews.

PMID- 29836590
TI  - Benighted.

PMID- 29836591
TI  - The Nursing Supplement.

PMID- 29836592
TI  - Middle Age.

PMID- 29836593
TI  - Vanity or Madness?

PMID- 29836594
TI  - An Ishmaelite.

PMID- 29836595
TI  - In and out among the Hospitals.

PMID- 29836596
TI  - The Hospitals Association and Patients' Contributions.

PMID- 29836598
TI  - An Asylum Romance: Being the Tale of a Traveller.

PMID- 29836597
TI  - Constructive Charity.

PMID- 29836599
TI  - Annotations: Fresh Fruit as Food.-The Battle of the Diets.

PMID- 29836600
TI  - Notes and News.

PMID- 29836601
TI  - The National Pension Fund.

PMID- 29836603
TI  - Everybody's Page.

PMID- 29836602
TI  - Hints for the Sick-Room.

PMID- 29836604
TI  - Foreign Hospital Intelligence.

PMID- 29836605
TI  - Social Pathology and Education.

PMID- 29836606
TI  - The Story of the Insane from Year to Year.

PMID- 29836607
TI  - Small-Pox.

PMID- 29836609
TI  - Hospital Festivals, Meetings, &c.

PMID- 29836608
TI  - Electricity and Its Use in Medicine: I. The Effect upon the Body in Health.

PMID- 29836610
TI  - Pneumonia.

PMID- 29836611
TI  - Construction Notes.

PMID- 29836612
TI  - The Field of Science.

PMID- 29836613
TI  - Annotations.

PMID- 29836615
TI  - Rectal Surgery.

PMID- 29836614
TI  - A Teaching University for London.

PMID- 29836616
TI  - The Hospital Nursing Supplement.

PMID- 29836617
TI  - The Irish Lunacy Blue Book.

PMID- 29836618
TI  - Around the Hospitals.

PMID- 29836619
TI  - Consumption and Infection.

PMID- 29836620
TI  - Practical Departments.

PMID- 29836621
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29836622
TI  - The International Medical Congress at Rome.

PMID- 29836623
TI  - Notes and News.

PMID- 29836624
TI  - Modern Medico-Psychology and Psychiatry: VI. The Men Who Have Made Modern
      Psychiatry.

PMID- 29836625
TI  - Notes and News.

PMID- 29836626
TI  - Hospital Festivals and Meetings.

PMID- 29836627
TI  - Practical Apects of Medical Science.

PMID- 29836628
TI  - Researches on Hydrides and Hydrates.

PMID- 29836629
TI  - The Hospital Nursing Supplement.

PMID- 29836630
TI  - The Lives We Have Bid to Be.

PMID- 29836632
TI  - The General Medical Council.

PMID- 29836631
TI  - Spinal Surgery.

PMID- 29836633
TI  - Diseases of the Nervous System.

PMID- 29836635
TI  - New Drugs and Preparations.

PMID- 29836634
TI  - Pelvic Peritonitis and Its Treatment.

PMID- 29836636
TI  - The Birmingham Hospital Saturday Fund.

PMID- 29836637
TI  - Exophthalmic Goitre and Its Relation to Diseases of the Thyroid Gland.

PMID- 29836639
TI  - New Appliances and Things Medical.

PMID- 29836638
TI  - Annotations.

PMID- 29836640
TI  - The Urine in Typhoid Fever.

PMID- 29836641
TI  - Annotations.

PMID- 29836642
TI  - Construction Notes.

PMID- 29836643
TI  - Myoma Uteri and Its Treatment.

PMID- 29836644
TI  - The Library of the Physician.

PMID- 29836645
TI  - Hospital Festivals and Meetings.

PMID- 29836646
TI  - The General Medical Council.

PMID- 29836647
TI  - Quinine in Malaria.

PMID- 29836648
TI  - New Drugs and Preparations.

PMID- 29836649
TI  - Surgery of the Intestines.

PMID- 29836651
TI  - Practical Departments.

PMID- 29836650
TI  - Exophthalmic Goitre and Its Relation to Diseases of the Thyroid Gland.

PMID- 29836653
TI  - The Field of Science.

PMID- 29836652
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29836654
TI  - Surgery of the OEsophagus and Stomach.

PMID- 29836655
TI  - The Birmingham Hospital Saturday Fund.

PMID- 29836656
TI  - Medical Aid Associations.

PMID- 29836657
TI  - The Hospital Nursing Supplement.

PMID- 29836658
TI  - Typhus Fever and Difficulties in Diagnosis.

PMID- 29836659
TI  - Notes and News.

PMID- 29836661
TI  - North London Hospital for Consumption.

PMID- 29836660
TI  - Around the Hospitals.

PMID- 29836662
TI  - Modern Medico-Psychology and Psychiatry: VII. Men Who Have Made Modern
      Psychiatry.

PMID- 29836664
TI  - The Humanity of Medicine.

PMID- 29836663
TI  - "The Hospital's" Special Hospital Sunday Supplement. 1894.

PMID- 29836666
TI  - Acute Intussusception. I.

PMID- 29836665
TI  - St. Mary's Hospital Festival Dinner.

PMID- 29836667
TI  - Researches on the Hydrides and Hydrates.

PMID- 29836669
TI  - Progress in Nervous Diseases.

PMID- 29836668
TI  - Some Aspects of Medical Science.

PMID- 29836670
TI  - How Workers Live.

PMID- 29836671
TI  - Observations Regarding Chronic Heart Disease Complicating Pregnancy and Labour.

PMID- 29836673
TI  - Notes and News.

PMID- 29836672
TI  - Around the Hospitals.

PMID- 29836674
TI  - Gonorrhoea and Its Effects.

PMID- 29836675
TI  - Annotations.

PMID- 29836676
TI  - The Hospital Nursing Supplement.

PMID- 29836677
TI  - The Birmingham Hospital Saturday Fund.

PMID- 29836678
TI  - Practical Points.

PMID- 29836679
TI  - New Appliances and Things Medical.

PMID- 29836680
TI  - The Hospital Nursing Supplement.

PMID- 29836681
TI  - Pulmonary Tuberculosis.

PMID- 29836682
TI  - Asylums in India: V. The Punjab.

PMID- 29836683
TI  - Hospital Festivals, Meetings, &c.

PMID- 29836684
TI  - Around the Hospitals.

PMID- 29836685
TI  - Annotations.

PMID- 29836687
TI  - Modern Views of Malaria. I.

PMID- 29836686
TI  - Loretine.

PMID- 29836688
TI  - Construction Notes.

PMID- 29836689
TI  - Patients' Payments.

PMID- 29836691
TI  - Notes and News.

PMID- 29836690
TI  - Famous Poisoners in Fiction: IX. The Favourite Poisons amongst Authors and
      Dramatists. Part I.

PMID- 29836692
TI  - Electricity and Its Use in Medicine. II.

PMID- 29836693
TI  - Modern Medico-Psychology and Psychiatry: III. Legislative and State Measures and
      their Effects.

PMID- 29836694
TI  - Drug Making and Drug Taking.

PMID- 29836695
TI  - Practical Departments.

PMID- 29836696
TI  - Dilatation of the Stomach.

PMID- 29836697
TI  - Malignant Growths.

PMID- 29836698
TI  - Ubi Est Morbus?

PMID- 29836700
TI  - Birmingham Hospital Saturday Fund.

PMID- 29836699
TI  - The International Medical Congress at Rome.

PMID- 29836701
TI  - The Hospital Nursing Supplement.

PMID- 29836702
TI  - Pleurisy.

PMID- 29836703
TI  - Congenital Displacement of the Head of the Femur and Its Treatment.

PMID- 29836705
TI  - Cysts and Fistula Arising in Connection with a Persistent Thyro-Glossal Duct.

PMID- 29836704
TI  - Mr. Gladstone on Medicine.

PMID- 29836707
TI  - London Hospital-Treatment of Acute Iritis.

PMID- 29836706
TI  - Practical Departments.

PMID- 29836708
TI  - Annotations.

PMID- 29836709
TI  - New Appliances and Things Medical.

PMID- 29836710
TI  - Sub-Diaphragmatic Abcess.

PMID- 29836711
TI  - Artificial Respiration in Chloroform Collapse.

PMID- 29836712
TI  - Hospital Festivals and Meetings.

PMID- 29836713
TI  - Our Doctors.

PMID- 29836715
TI  - Surgery of the Lungs and Pleurae.

PMID- 29836714
TI  - The Memorial to Sir Andrew Clark.

PMID- 29836716
TI  - New Drugs and Praparations.

PMID- 29836717
TI  - Around the Hospitals.

PMID- 29836718
TI  - Notes and News.

PMID- 29836719
TI  - Modern Medico-Psychology and Psychiatry: V. The Men Who Have Made Modern
      Psychiatry.

PMID- 29836720
TI  - The Field of Science.

PMID- 29836721
TI  - Hospital Festivals and Meetings.

PMID- 29836723
TI  - Fevers and Infectious Diseases.

PMID- 29836722
TI  - First Traces and Their Interpretation.

PMID- 29836724
TI  - Observations Regarding Chronic Heart Disease Complicating Pregnancy and Labour.

PMID- 29836725
TI  - Acute Intussusception. II.

PMID- 29836726
TI  - Around the Hospitals.

PMID- 29836727
TI  - Notes and News.

PMID- 29836729
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29836728
TI  - Eucalyptus Oil.

PMID- 29836730
TI  - Birmingham Hospital Saturday Fund.

PMID- 29836731
TI  - Surgery of the Intestines.

PMID- 29836732
TI  - The Mansion House Hospital Sunday Conversazione.

PMID- 29836733
TI  - St. Thomas's Hospital Medical School.

PMID- 29836734
TI  - Annotations.

PMID- 29836735
TI  - The Decay of Surgery.

PMID- 29836736
TI  - Reactionary Medicine.

PMID- 29836737
TI  - New Appliances and Things Medical.

PMID- 29836738
TI  - The Hospital Nursing Supplement.

PMID- 29836739
TI  - Some Aspects of Medical Science.

PMID- 29836740
TI  - Hospital Festivals and Meetings.

PMID- 29836741
TI  - On Some Manifestations of Scorbutic Disease in Children.

PMID- 29836742
TI  - Around the Hospitals.

PMID- 29836744
TI  - Notes and News.

PMID- 29836743
TI  - Diseases of the Ear: I. The Examination of the Ear.

PMID- 29836745
TI  - Medical Ethics.

PMID- 29836746
TI  - Practical Points.

PMID- 29836747
TI  - Language and Race.

PMID- 29836748
TI  - The Field of Science.

PMID- 29836750
TI  - Annotations.

PMID- 29836749
TI  - Malignant Growths.

PMID- 29836751
TI  - The Hospital Nursing Supplement.

PMID- 29836752
TI  - The Story of the Insane from Year to Year.

PMID- 29836753
TI  - The Homoeopathic Hospital, Great Ormond Street.

PMID- 29836755
TI  - A Physician to Physicians.

PMID- 29836754
TI  - Liver and Gall Bladder.

PMID- 29836757
TI  - The Library of the Chirurgeon.

PMID- 29836756
TI  - New Appliances and Things Medical.

PMID- 29836758
TI  - Typhoid.

PMID- 29836759
TI  - Surgery of Pancreas and Spleen.

PMID- 29836760
TI  - St. Thomas's Hospital.

PMID- 29836761
TI  - A Provident Scheme.

PMID- 29836762
TI  - Hernia.

PMID- 29836764
TI  - Notes and News.

PMID- 29836763
TI  - Some Simple Uses of Carbolic Acid. II.

PMID- 29836765
TI  - New Appliances and Things Medical.

PMID- 29836766
TI  - Remarks on the Gravity of Any Discharge from the Ear.

PMID- 29836767
TI  - Hospital Festivals and Meetings.

PMID- 29836768
TI  - Construction Notes.

PMID- 29836769
TI  - Typhoid Fever.

PMID- 29836770
TI  - Paris.

PMID- 29836771
TI  - The Plagues of the Bible.

PMID- 29836772
TI  - Germs Not Pathological.

PMID- 29836774
TI  - The Hospital Nursing Supplement.

PMID- 29836773
TI  - The Birmingham Hospital Saturday Fund.

PMID- 29836775
TI  - The History and Capabilities of Herbal Simples: Hemlock and Henbane.

PMID- 29836777
TI  - Appendicitis.

PMID- 29836776
TI  - Modern Medico Psychology and Psychiatry: The Forms and Classification of Mental
      Diseases.

PMID- 29836778
TI  - Annotations.

PMID- 29836779
TI  - Some Further Notes on the Hydrides.

PMID- 29836781
TI  - How Workers Live.

PMID- 29836780
TI  - New Drugs and Preparations.

PMID- 29836782
TI  - Construction Notes.

PMID- 29836783
TI  - Abdominal Surgery.

PMID- 29836784
TI  - Middlesex Hospital Festival Dinner.

PMID- 29836785
TI  - New Appliances and Things Medical.

PMID- 29836786
TI  - Madness or What?: I. Jeanne d'Arc.

PMID- 29836787
TI  - Tinea Tonsurans.

PMID- 29836788
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29836789
TI  - The First English Translations.

PMID- 29836790
TI  - The Hospital Nursing Supplement.

PMID- 29836791
TI  - School Fevers.

PMID- 29836792
TI  - Treatment of Club-Foot.

PMID- 29836793
TI  - New Drugs and Praparations.

PMID- 29836794
TI  - Practical Departments.

PMID- 29836795
TI  - Annotations.

PMID- 29836796
TI  - Around the Hospitals.

PMID- 29836797
TI  - Notes and News.

PMID- 29836798
TI  - Pulmonary Tuberculosis.

PMID- 29836799
TI  - The Homes of England.

PMID- 29836800
TI  - How to Avoid the Troubles Which Are Due to Uric Acid. II.

PMID- 29836801
TI  - Progress in Surgery.

PMID- 29836802
TI  - The Defects of Medical Assurance.

PMID- 29836803
TI  - Around the Hospitals.

PMID- 29836804
TI  - Modern Views of Malaria. II.

PMID- 29836805
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29836807
TI  - The Hospital Nursing Supplement.

PMID- 29836806
TI  - Gout in Hospitals.

PMID- 29836808
TI  - The Cure of Stammering.

PMID- 29836809
TI  - Medical Progress.

PMID- 29836810
TI  - New Drugs and Preparations.

PMID- 29836811
TI  - Metropolitan and National Nursing Association.

PMID- 29836812
TI  - Modern Surgery.

PMID- 29836813
TI  - Annotations.

PMID- 29836814
TI  - The Educational Treatment of Idiots, Imbeciles, and Feeble-Minded Children: II.

PMID- 29836815
TI  - On the Causes of Haemorrhage during Pregnancy.

PMID- 29836817
TI  - Notes and News.

PMID- 29836816
TI  - New Appliances and Things Medical.

PMID- 29836818
TI  - Metropolitan Hospital Dinner.

PMID- 29836819
TI  - The Localisation of Sensation in the Brain.

PMID- 29836820
TI  - Rational Therapeutics and Therapeuticians.

PMID- 29836822
TI  - Notes and News.

PMID- 29836821
TI  - Intra-Uterine Syringing in Puerperal Septicaemia.

PMID- 29836823
TI  - The Hospital Nursing Supplement.

PMID- 29836824
TI  - Hospital Administration.

PMID- 29836825
TI  - Construction Notes.

PMID- 29836826
TI  - The Story of the Insane from Year to Year.

PMID- 29836828
TI  - Progress in Dermatology.

PMID- 29836827
TI  - Hospital Festivals and Meetings.

PMID- 29836829
TI  - Annotations.

PMID- 29836830
TI  - Tuberculosis.

PMID- 29836832
TI  - The Library of the Physician.

PMID- 29836831
TI  - The Field of Science.

PMID- 29836833
TI  - On Modern Progress in Ophthalmic Medicine and Surgery.

PMID- 29836834
TI  - Around the Hospitals.

PMID- 29836835
TI  - New Appliances and Things Medical.

PMID- 29836837
TI  - New Appliances and Things Medical.

PMID- 29836836
TI  - Cranial Surgery.

PMID- 29836838
TI  - Preventable Mortality at Sea.

PMID- 29836839
TI  - Diseases of the Eye.

PMID- 29836841
TI  - The Field of Science.

PMID- 29836840
TI  - Pulmonary Tuberculosis.

PMID- 29836843
TI  - Annotations.

PMID- 29836842
TI  - Practical Departments.

PMID- 29836844
TI  - Around the Hospitals.

PMID- 29836845
TI  - Artificial Respiration in Chloroform Collapse.

PMID- 29836846
TI  - The Place of Medicine in Civilisation.

PMID- 29836847
TI  - Construction Notes.

PMID- 29836848
TI  - Notes and News.

PMID- 29836849
TI  - New Drugs and Preparations.

PMID- 29836850
TI  - Modern Medico-Psychology and Psychiatry: IV.

PMID- 29836852
TI  - Prospects for the Future.

PMID- 29836851
TI  - On Temperature Charts.

PMID- 29836853
TI  - Hospital Festivals, Meetings, &c.

PMID- 29836854
TI  - The Diagnostic Significance of Certain Signs and Symptoms in Joint Disease.

PMID- 29836855
TI  - Peritonitis.

PMID- 29836856
TI  - The Hospital Nursing Supplement.

PMID- 29836857
TI  - Practical Aspects of Medical Science.

PMID- 29836858
TI  - The History and Capabilities of Herbal Simples: The Common Ragwort.

PMID- 29836859
TI  - Modern Medico-Psychology and Psychiatry: IX. Forms and Classification of Mental
      Disease.

PMID- 29836861
TI  - The Hospital Nursing Supplement.

PMID- 29836860
TI  - Diseases of the Ear: II. The Examination of the Ear.

PMID- 29836862
TI  - Kidney Diseases.

PMID- 29836863
TI  - Hospitals in India: II. The Madras Presidency (1).

PMID- 29836864
TI  - Some Aspects of Medical Science.

PMID- 29836865
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Senile Cataract
      (continued).

PMID- 29836867
TI  - Renal Surgery.

PMID- 29836866
TI  - Construction Notes.

PMID- 29836868
TI  - Notes and News.

PMID- 29836869
TI  - Paris.

PMID- 29836870
TI  - Hospital Festivals and Meetings.

PMID- 29836871
TI  - Around the Hospitals.

PMID- 29836872
TI  - Vaccination: A New Research.

PMID- 29836873
TI  - New Appliances and Things Medical.

PMID- 29836875
TI  - General Surgery.

PMID- 29836874
TI  - Gastric Ulcer and Its Treatment.

PMID- 29836876
TI  - The Story of the Insane from Year to Year.

PMID- 29836877
TI  - Finance Administration.

PMID- 29836879
TI  - Annotations.

PMID- 29836878
TI  - The Treatment of Wounds.

PMID- 29836880
TI  - How Workers Live-The Woollen Industry.

PMID- 29836881
TI  - Practical Departments.

PMID- 29836883
TI  - Annotations.

PMID- 29836882
TI  - New Appliances and Things Medical.

PMID- 29836884
TI  - The Annual Museum.

PMID- 29836885
TI  - The Treatment of Fractures by Some of the Simpler Methods.

PMID- 29836886
TI  - Ethics and Administration.

PMID- 29836887
TI  - Bone, Joint, and Orthopaedic Surgery.

PMID- 29836888
TI  - Health and Holiness.

PMID- 29836889
TI  - Operative Surgeons.-The Great Untaught.

PMID- 29836890
TI  - Queen's Jubilee Hospital.

PMID- 29836891
TI  - The Hospital Nursing Supplement.

PMID- 29836892
TI  - Construction Notes.

PMID- 29836893
TI  - Notes and News.

PMID- 29836894
TI  - Around the Hospitals.

PMID- 29836895
TI  - Diseases of the Vascular System.

PMID- 29836896
TI  - Hospitals in India.

PMID- 29836898
TI  - Fry's Cocoas and Chocolates.

PMID- 29836897
TI  - Modern Medico-Psychology and Psychiatry: X. Condition of Mental Exaltation and
      Excitement.

PMID- 29836900
TI  - Curiosities of American Lunacy.

PMID- 29836899
TI  - The Story of the Insane from Year to Year.

PMID- 29836902
TI  - The Costliness of Modern Treatment.

PMID- 29836901
TI  - The Hospital Nursing Supplement.

PMID- 29836903
TI  - Notes and News.

PMID- 29836904
TI  - Fibro-Myomatous Tumours of the Uterus Producing Bladder Symptoms.

PMID- 29836905
TI  - Street Collections.

PMID- 29836906
TI  - The Early History of the Hospital Sunday and Saturday Funds.

PMID- 29836907
TI  - Potassium Ethylate.

PMID- 29836908
TI  - The Story of the Insane from Year to Year.

PMID- 29836909
TI  - The Annual Museum.

PMID- 29836910
TI  - Cocoas and Chocolates.

PMID- 29836911
TI  - Construction Notes.

PMID- 29836912
TI  - The Earliest Herbals.

PMID- 29836913
TI  - Around the Hospitals.

PMID- 29836915
TI  - New Appliances and Things Medical.

PMID- 29836914
TI  - The Treatment of Habitual Constipation.

PMID- 29836916
TI  - Annotations.

PMID- 29836917
TI  - Progress in Medicine.

PMID- 29836918
TI  - Around the Hospitals.

PMID- 29836919
TI  - The Educational Treatment of Idiots, Imbeciles, and Feeble Minded Children: V.
      Results of Special Training.

PMID- 29836921
TI  - Annotations.

PMID- 29836920
TI  - Continental Notes from a Holiday Correspondent.

PMID- 29836922
TI  - The Hospital Nursing Supplement.

PMID- 29836923
TI  - Notes and News.

PMID- 29836924
TI  - General Hospitals.

PMID- 29836925
TI  - Surgery of the Lungs and Pleura.

PMID- 29836927
TI  - Bone, Joint, and Orthopaedic Surgery.

PMID- 29836926
TI  - Chronic Catarrh of the Middle Ear.-III.

PMID- 29836928
TI  - New Appliances and Things Medical.

PMID- 29836929
TI  - The Story of the Insane from Year to Year.

PMID- 29836930
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Laminar Cataract.

PMID- 29836931
TI  - Holiday Thoughts for Health Makers.

PMID- 29836932
TI  - The British Medical Association at Bristol.

PMID- 29836933
TI  - A Visit to the Hospitals at Montreal.

PMID- 29836934
TI  - Practical Departments.

PMID- 29836935
TI  - Modern Medico-Psychology and Psychiatry: XI.-Conditions of Mental Exaltation and
      Excitement.

PMID- 29836936
TI  - Around the Hospitals.

PMID- 29836937
TI  - Annotations.

PMID- 29836938
TI  - The Medical Student's Vade Mecum: The Metropolitan Medical Schools.-The London
      Hospital College-Guy's-St. Bartholomew's-St Thomas's-University College-King's
      College-Middlesex-St. George's-St. Mary's-Charing Cross-Westminster-The School of
      Medicine for Women-Fees.

PMID- 29836940
TI  - Student Life in the Sixteenth Century.

PMID- 29836939
TI  - The International Congress at Buda Pesth.

PMID- 29836942
TI  - The Hospital Nursing Supplement.

PMID- 29836941
TI  - Notes and News.

PMID- 29836943
TI  - Labour and Health.-II. Wanted, More Air.

PMID- 29836944
TI  - Progress in Medicine.

PMID- 29836945
TI  - Around the Hospitals.

PMID- 29836946
TI  - Medical Education in Scotland.

PMID- 29836947
TI  - Koch on Cholera.

PMID- 29836948
TI  - Construction Notes.

PMID- 29836949
TI  - Notes on the Methods of Performing Paracentesis of the Various Cavitives.

PMID- 29836950
TI  - Medical Education in the Provinces.

PMID- 29836951
TI  - The Cost of Provisions.

PMID- 29836952
TI  - Practical Points.

PMID- 29836953
TI  - On Toxic Neutralisations: I.-Isomeric Variation.

PMID- 29836954
TI  - The Field of Science.

PMID- 29836955
TI  - Reminiscences of Buda Pesth and the International Congress of Hygiene.

PMID- 29836957
TI  - Notes and News.

PMID- 29836956
TI  - The Hospital Nursing Supplement.

PMID- 29836959
TI  - Annotations.

PMID- 29836958
TI  - Diseases of the Ear: V.-The Artificial Membrana Tympani.

PMID- 29836960
TI  - Hospital Laundries.

PMID- 29836961
TI  - Chronic Catarrh of the Middle Ear.

PMID- 29836962
TI  - Annotations.

PMID- 29836963
TI  - Madness Or-What?: II. The Terrible Czar.

PMID- 29836965
TI  - Practical Departments.

PMID- 29836964
TI  - Hospital Festivals and Meetings.

PMID- 29836966
TI  - Around the Hospitals.

PMID- 29836968
TI  - The Convalescent Home of the Royal Infirmary of Edinburgh, Corstorphine.

PMID- 29836967
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Laminar Cataract
      (continued).

PMID- 29836969
TI  - Doctors in Council.

PMID- 29836970
TI  - Construction Notes.

PMID- 29836971
TI  - Diseases of Children.

PMID- 29836972
TI  - The Hospital Nursing Supplement.

PMID- 29836973
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29836974
TI  - New Appliances and Things Medical.

PMID- 29836975
TI  - Bone, Joint, and Orthopaedic Surgery.

PMID- 29836976
TI  - Notes and News.

PMID- 29836977
TI  - On Modern Progress in Ophthalmic Medicine and Surgery: Laminar Cataract.

PMID- 29836978
TI  - The Educational Treatment of Idiots, Imbeciles, and Feeble-Minded Children: III.

PMID- 29836979
TI  - Notes and News.

PMID- 29836980
TI  - The Operative Treatment of Cancer with Special Reference to Cancer of the Breast.

PMID- 29836981
TI  - Diseases of the Ear: IV. Foreign Bodies in the Ear.

PMID- 29836982
TI  - Annotations.

PMID- 29836983
TI  - The New Derbyshire Royal Infirmary.

PMID- 29836984
TI  - The Doctor Afloat.

PMID- 29836985
TI  - Diseases of Children.

PMID- 29836986
TI  - The Story of the Insane from Year to Year.

PMID- 29836987
TI  - Famous Poisoners in Fiction: X. The Favourite Poisons of Authors and Dramatists.
      Part II.

PMID- 29836989
TI  - Editor's Letter-Box.

PMID- 29836988
TI  - The Hospital Nursing Supplement.

PMID- 29836991
TI  - General Surgery.

PMID- 29836990
TI  - Around the Hospitals.

PMID- 29836992
TI  - Continental Notes from a Holiday Correspondent.

PMID- 29836993
TI  - The Field of Science.

PMID- 29836994
TI  - Asylums in India: VI. Burma: The Rangoon Asylum.

PMID- 29836995
TI  - The Royal Visit to Birmingham.

PMID- 29836997
TI  - The Story of the Insane from Year to Year.

PMID- 29836996
TI  - Around the Hospitals.

PMID- 29836998
TI  - Diseases of the Heart and Vascular System. II.

PMID- 29836999
TI  - Chronic Catarrh of the Middle Ear -IV.

PMID- 29837000
TI  - New Appliances and Things Medical.

PMID- 29837001
TI  - Vaccination and Compulsory Vaccination.

PMID- 29837002
TI  - The Hospital Laundry.

PMID- 29837003
TI  - The British Medical Association at Bristol.

PMID- 29837004
TI  - A Bureau of Autopsy.

PMID- 29837005
TI  - Annotations.

PMID- 29837006
TI  - The Hospital Nursing Supplement.

PMID- 29837007
TI  - Labour and Health.

PMID- 29837008
TI  - Notes and News.

PMID- 29837009
TI  - Small-Pox and Vaccination at Leicester.

PMID- 29837010
TI  - Construction Notes.

PMID- 29837011
TI  - Madness Or-What? III.-The Kings of Spain.

PMID- 29837013
TI  - Baden-Baden.

PMID- 29837012
TI  - Surgery of the Lungs and Pleura.

PMID- 29837015
TI  - The Ethylates, or Caustic Alcohols.

PMID- 29837014
TI  - The British Medical Association.

PMID- 29837016
TI  - Practical Departments.

PMID- 29837017
TI  - Notes and News.

PMID- 29837018
TI  - Some Aspects of Medical Science.

PMID- 29837019
TI  - Periscope of Dermatology.

PMID- 29837020
TI  - Around the Hospitals.

PMID- 29837021
TI  - Canon Ainger's True Physician.

PMID- 29837022
TI  - Annotations.

PMID- 29837024
TI  - The Hospital Nursing Supplement.

PMID- 29837023
TI  - Innocent Tumours of the Rectum.

PMID- 29837026
TI  - Bacteriology in the Diagnosis of Diphtheria.

PMID- 29837025
TI  - Construction Notes.

PMID- 29837028
TI  - Notes and News.

PMID- 29837027
TI  - Genito-Urinary Surgery.

PMID- 29837029
TI  - Periscope of Dermatology.

PMID- 29837030
TI  - The Educational Treatment of Idiots, Imbeciles, and Feeble-Minded Children: IV.
      The Industrial Training of the Imbecile.

PMID- 29837032
TI  - Continental Notes from a Holiday Correspondent.

PMID- 29837031
TI  - Hygiene in University Education.

PMID- 29837033
TI  - On Malignant Tumours of the Rectum.

PMID- 29837034
TI  - The British Medical Association at Bristol.

PMID- 29837035
TI  - The Hospital Nursing Supplement.

PMID- 29837037
TI  - Annotations.

PMID- 29837036
TI  - Lord Salisbury's Address.

PMID- 29837039
TI  - The Ethylates, or Caustic Alcohols.

PMID- 29837038
TI  - Notes and News.

PMID- 29837041
TI  - Dr. Pavy's Researches on Diabetes.

PMID- 29837040
TI  - A Lunatic's Relatives.

PMID- 29837042
TI  - Around the Hospitals.

PMID- 29837043
TI  - Chelsea Hospital for Women.

PMID- 29837044
TI  - Chronic Catarrh of the Middle Ear.

PMID- 29837045
TI  - Annotations.

PMID- 29837046
TI  - Diseases of Children.

PMID- 29837047
TI  - Hospital Festivals and Meetings.

PMID- 29837049
TI  - The Hospital Nursing Supplement.

PMID- 29837048
TI  - General Surgery.

PMID- 29837050
TI  - The Chelsea Hospital for Women.

PMID- 29837051
TI  - Bone, Joint, and Orthopaedic Surgery.

PMID- 29837052
TI  - Practical Departments.

PMID- 29837053
TI  - New Appliances and Things Medical.

PMID- 29837055
TI  - Practical Departments.

PMID- 29837054
TI  - Chelsea Hospital for Women.

PMID- 29837056
TI  - Scarlet Fever.

PMID- 29837057
TI  - The Role of Bromine in Therapeutics and Bromal Hydrate.

PMID- 29837058
TI  - The Treatment of Angular Deformity of the Spine, or Spinal Caries.

PMID- 29837059
TI  - Practical Points.

PMID- 29837060
TI  - How Workers Live-The Cotton Industry.

PMID- 29837062
TI  - The Secrets of Alexis.

PMID- 29837061
TI  - Some Aspects of Medical Science.

PMID- 29837063
TI  - New Drugs and Preparations.

PMID- 29837064
TI  - Construction Notes.

PMID- 29837065
TI  - Notes and News.

PMID- 29837066
TI  - The New Derbyshire Royal Infirmary.

PMID- 29837067
TI  - The Hospital Nursing Supplement.

PMID- 29837068
TI  - Annotations.

PMID- 29837070
TI  - Diseases of the Ear: III.

PMID- 29837069
TI  - Around the Hospitals.

PMID- 29837071
TI  - New Appliances and Things Medical.

PMID- 29837072
TI  - Hospital Festivals and Meetings.

PMID- 29837073
TI  - The Summits of Medical Progress.

PMID- 29837074
TI  - Away with Quacks and Prescribing Chemists.

PMID- 29837076
TI  - Nasal Reflexes.

PMID- 29837075
TI  - Story of the Insane from Year to Year.

PMID- 29837077
TI  - Further Observations on the Arrest of Puerperal Fever by Inhibition of the Pulse.

PMID- 29837079
TI  - Progress in Surgery.

PMID- 29837078
TI  - Note on Intraperitoneal Injections.

PMID- 29837080
TI  - Hospital Notes.

PMID- 29837081
TI  - Annotations.

PMID- 29837082
TI  - Construction Notes.

PMID- 29837083
TI  - The Notification of Tuberculosis.

PMID- 29837084
TI  - Hospital Meetings, &c.

PMID- 29837085
TI  - Progress in Medicine.

PMID- 29837086
TI  - Quarantine.

PMID- 29837087
TI  - Notes and News.

PMID- 29837088
TI  - Fire or Frost in Medicine?

PMID- 29837089
TI  - Child Life under Queen Victoria: VI. Agricultural Gangs.

PMID- 29837091
TI  - "The Hospital" Nursing Mirror.

PMID- 29837090
TI  - New Appliances and Things Medical.

PMID- 29837092
TI  - The Harveian Society.

PMID- 29837093
TI  - Progress in Medicine.

PMID- 29837095
TI  - Notes and News.

PMID- 29837094
TI  - Annotations.

PMID- 29837096
TI  - A Disgrace to England.

PMID- 29837097
TI  - "The Hospital" Nursing Mirror.

PMID- 29837099
TI  - Progress in Surgery.

PMID- 29837098
TI  - Medical Society.

PMID- 29837100
TI  - Hospital Meetings, &c.

PMID- 29837101
TI  - Child Life under Queen Victoria: VII. Merely Players.

PMID- 29837102
TI  - The Dangers of Anaesthetics.

PMID- 29837103
TI  - Editor's Letter-Box.

PMID- 29837105
TI  - The Waning of the Plague.

PMID- 29837104
TI  - The Diagnosis of Cancer of the Uterus.

PMID- 29837106
TI  - New Appliances and Things Medical.

PMID- 29837107
TI  - Progress in Medicine.

PMID- 29837108
TI  - The Oxygen Treatment of Ulcers.

PMID- 29837109
TI  - Hospital Construction.

PMID- 29837110
TI  - Annotations.

PMID- 29837111
TI  - Royal Medical and Chirurgical Society.

PMID- 29837112
TI  - Hospital Expenditure-The Commissariat.

PMID- 29837113
TI  - Child Life under Queen Victoria: V. The Climbing Boys.

PMID- 29837114
TI  - The Oxygen Treatment of Ulcers-An Anonymous Symposium.

PMID- 29837115
TI  - New Appliances and Things Medical.

PMID- 29837116
TI  - Influenza and Insanity.

PMID- 29837117
TI  - The Medical Society.

PMID- 29837118
TI  - "The Hospital" Nursing Mirror.

PMID- 29837119
TI  - Hospital Meetings, &c.

PMID- 29837120
TI  - Progress in Surgery.

PMID- 29837121
TI  - Notes and News.

PMID- 29837122
TI  - Hospitals, Tenders, and Contractors.

PMID- 29837123
TI  - Editor's Letter-Box.

PMID- 29837125
TI  - The Hospital Nursing Supplement.

PMID- 29837124
TI  - Annotations.

PMID- 29837127
TI  - Waiting Mortuaries.

PMID- 29837126
TI  - Progress in Medicine.

PMID- 29837128
TI  - Clinical Society.

PMID- 29837129
TI  - Notes and News.

PMID- 29837130
TI  - Practical Points.

PMID- 29837131
TI  - Progress in Surgery.

PMID- 29837132
TI  - New Appliances and Things Medical.

PMID- 29837133
TI  - Prognosis in Scarlet Fever.

PMID- 29837134
TI  - Modern Sociology.

PMID- 29837135
TI  - The Riddle of Pain.

PMID- 29837137
TI  - New Appliances and Things Medical.

PMID- 29837136
TI  - Within the Hospitals.

PMID- 29837138
TI  - Progress in Surgery.

PMID- 29837139
TI  - Alcohol in Acute Disease.

PMID- 29837140
TI  - The Hospital Nursing Supplement.

PMID- 29837142
TI  - The Medical Society.

PMID- 29837144
TI  - Modern Sociology.

PMID- 29837143
TI  - Annotations.

PMID- 29837145
TI  - The Jubilee of Anaesthesia.

PMID- 29837146
TI  - Hospital Expenditure-The Commissariat.

PMID- 29837147
TI  - The Clinical Society.

PMID- 29837148
TI  - The Jubilee of Anaesthetics.

PMID- 29837149
TI  - Infectious Diseases in Dublin.

PMID- 29837150
TI  - Notes and News.

PMID- 29837151
TI  - Progress in State Medicine.

PMID- 29837152
TI  - The Medical Society.

PMID- 29837153
TI  - Notes and News.

PMID- 29837154
TI  - Progress in Surgery.

PMID- 29837155
TI  - Modern Sociology.

PMID- 29837156
TI  - Instrumental Aids to the Administration of Anaesthetics.

PMID- 29837157
TI  - The Hospital Nursing Supplement.

PMID- 29837159
TI  - Should Doctors Be Peers?

PMID- 29837158
TI  - Angina Ludovici.

PMID- 29837160
TI  - The Clinical Society.

PMID- 29837161
TI  - The Guild of St. Luke.

PMID- 29837162
TI  - The Transport of Invalids by Rail.

PMID- 29837163
TI  - The Story of the Insane from Year to Year.

PMID- 29837164
TI  - Progress in Medicine.

PMID- 29837165
TI  - Annotations.

PMID- 29837167
TI  - The Medical Society.

PMID- 29837166
TI  - Progress in Medicine.

PMID- 29837168
TI  - New Appliances and Things Medical.

PMID- 29837169
TI  - Progress in Surgery.

PMID- 29837171
TI  - The Isolation of Scarlet Fever Patients.

PMID- 29837170
TI  - Annotations.

PMID- 29837172
TI  - Notes and News.

PMID- 29837173
TI  - Physical Inferiority and Crime.

PMID- 29837174
TI  - Hospital Meetings, &c.

PMID- 29837175
TI  - "The Hospital" Nursing Mirror.

PMID- 29837176
TI  - Child Life under Queen Victoria: III. The First Factory Acts.

PMID- 29837177
TI  - Hospital Construction.

PMID- 29837178
TI  - The Harveian Society.

PMID- 29837179
TI  - Royal Statistical Society.

PMID- 29837180
TI  - Bunions and Their Treatment.

PMID- 29837181
TI  - Hospital Expenditure-The Commissariat.

PMID- 29837182
TI  - New Appliances and Things Medical.

PMID- 29837183
TI  - Annotations.

PMID- 29837184
TI  - The Story of the Insane from Year to Year.

PMID- 29837185
TI  - The Hospital Nursing Supplement.

PMID- 29837187
TI  - The Fate of the Infirm.

PMID- 29837186
TI  - Progress in Surgery.

PMID- 29837189
TI  - Construction Notes.

PMID- 29837188
TI  - The Infection of Scarlet Fever.

PMID- 29837190
TI  - The Introductory Addresses at the Medical Schools.

PMID- 29837191
TI  - Around the Hospitals.

PMID- 29837192
TI  - The Asylums Board and London Fevers.

PMID- 29837193
TI  - Practical Departments.

PMID- 29837195
TI  - Hospital Construction.

PMID- 29837194
TI  - Notes and News.

PMID- 29837196
TI  - Annotations.

PMID- 29837197
TI  - The Serum Treatment of Puerperal Fever.

PMID- 29837199
TI  - The London Water Supply.

PMID- 29837198
TI  - Notes and News.

PMID- 29837201
TI  - Pathological Society.

PMID- 29837200
TI  - Modern Sociology.

PMID- 29837203
TI  - The Hospital Nursing Supplement.

PMID- 29837202
TI  - The Early Diagnosis of Insanity.

PMID- 29837204
TI  - Surgical Ritual.

PMID- 29837205
TI  - Progress in Surgery.

PMID- 29837206
TI  - New Appliances and Things Medical.

PMID- 29837207
TI  - Progress in Medicine.

PMID- 29837208
TI  - The Hospital Nursing Supplement.

PMID- 29837209
TI  - Annotations.

PMID- 29837211
TI  - The Retrogression of Cancer.

PMID- 29837210
TI  - The Trade in Oysters.

PMID- 29837212
TI  - New Appliances and Things Medical.

PMID- 29837213
TI  - Hospital Administration.

PMID- 29837214
TI  - A Clinical Demonstration.

PMID- 29837215
TI  - Construction Notes.

PMID- 29837216
TI  - The General Medical Council.

PMID- 29837217
TI  - Servants and Medical Men.

PMID- 29837218
TI  - Notes and News.

PMID- 29837220
TI  - Modern Sociology.

PMID- 29837219
TI  - Cottage Hospitals and Medical Fees.

PMID- 29837221
TI  - A Vaccination Crusade.

PMID- 29837222
TI  - Royal Medical and Chirurgical Society.

PMID- 29837223
TI  - Notes and News.

PMID- 29837224
TI  - New Appliances and Things Medical.

PMID- 29837226
TI  - Clinical Society.

PMID- 29837225
TI  - Some Moral Aspects of the C. D. Acts.

PMID- 29837228
TI  - Child Life under Queen Victoria: IV. The Colliery Children.

PMID- 29837227
TI  - "Shelters" and Sanitation.

PMID- 29837230
TI  - The Anti-Vaccinators' Case in the Report of the Vaccination Commission.

PMID- 29837229
TI  - Epidemiological Society.

PMID- 29837231
TI  - The Oxygen Treatment of Wounds.

PMID- 29837232
TI  - "The Hospital" Nursing Mirror.

PMID- 29837233
TI  - Annotations.

PMID- 29837234
TI  - The Bill for the Registration of Midwives, 1897.

PMID- 29837235
TI  - Hospital Meetings, &c.

PMID- 29837236
TI  - On the Undiminished Mortality from Puerperal Fever in England and Wales.

PMID- 29837238
TI  - Progress in Surgery.

PMID- 29837237
TI  - Progress in Medicine.

PMID- 29837240
TI  - Notes and News.

PMID- 29837239
TI  - New Appliances and Things Medical.

PMID- 29837242
TI  - Annotations.

PMID- 29837241
TI  - Progress in Surgery.

PMID- 29837244
TI  - "The Hospital" Nursing Mirror.

PMID- 29837243
TI  - Progress in Medicine.

PMID- 29837245
TI  - A House Divided against Itself.

PMID- 29837246
TI  - The Treatment of Infectious Diseases Arising in Children's Hospitals.

PMID- 29837248
TI  - The Medical Society.

PMID- 29837249
TI  - Modern Sociology.

PMID- 29837251
TI  - Hospital Administration.

PMID- 29837250
TI  - The Story of the Insane from Year to Year.

PMID- 29837253
TI  - The Pathological Society.

PMID- 29837252
TI  - Modern Sociology.

PMID- 29837255
TI  - What Is a Cure?

PMID- 29837254
TI  - Progress in Medicine.

PMID- 29837256
TI  - The Harveian Society.

PMID- 29837257
TI  - The Complete Diagnosis of Disease of the Heart.

PMID- 29837258
TI  - Notes and News.

PMID- 29837261
TI  - The Prevention and Cure of Tuberculosis.

PMID- 29837259
TI  - The Story of the Insane from Year to Year.

PMID- 29837263
TI  - Editor's Letter-Box.

PMID- 29837262
TI  - Hospital Construction.

PMID- 29837265
TI  - The Hospital Nursing Supplement.

PMID- 29837264
TI  - Annotations.

PMID- 29837267
TI  - The Hospital Nursing Supplement.

PMID- 29837266
TI  - Instrumental Aids to the Administration of Anaesthetics.

PMID- 29837269
TI  - The Story of the Insane from Year to Year.

PMID- 29837268
TI  - Hospital Administration.

PMID- 29837271
TI  - New Appliances and Things Medical.

PMID- 29837270
TI  - "The Hospital" to Its Readers.

PMID- 29837273
TI  - A Doctors' Union.

PMID- 29837272
TI  - Progress in Surgery.

PMID- 29837274
TI  - Annotations.

PMID- 29837275
TI  - On the Treatment of Tuberculous Disease of the Hip-Joint.

PMID- 29837276
TI  - Erichsen and Humphry.

PMID- 29837277
TI  - Modern Sociology.

PMID- 29837278
TI  - Progress in Medicine.

PMID- 29837280
TI  - Notes and News.

PMID- 29837281
TI  - Llangammarch Wells as a Health Resort.

PMID- 29837282
TI  - Hospital Construction.

PMID- 29837284
TI  - Progress in Medicine.

PMID- 29837283
TI  - Cottage Hospitals and Medical Fees.

PMID- 29837285
TI  - 1896: A Retrospect.

PMID- 29837286
TI  - Annotations.

PMID- 29837288
TI  - Construction Notes.

PMID- 29837287
TI  - Some Pitfalls of Practice.

PMID- 29837289
TI  - Hospital Notes.

PMID- 29837290
TI  - The "Censure" on the Metropolitan Hospital.

PMID- 29837291
TI  - Tramways and Healthy Dwellings.

PMID- 29837292
TI  - "The Hospital" Nursing Mirror.

PMID- 29837294
TI  - The Medico-Psychological Association and Their Nurses.

PMID- 29837293
TI  - Practical Departments.

PMID- 29837295
TI  - Ununited Fracture: Its Causes and Treatment.

PMID- 29837296
TI  - Progress in Surgery.

PMID- 29837297
TI  - Progress in Medicine.

PMID- 29837298
TI  - The Plague.

PMID- 29837299
TI  - New Appliances and Things Medical.

PMID- 29837300
TI  - Annotations.

PMID- 29837302
TI  - Progress in Surgery.

PMID- 29837301
TI  - Hospital Meetings, &c.

PMID- 29837303
TI  - Whitlow.

PMID- 29837304
TI  - Hospital Nurses in Asylum Service.

PMID- 29837305
TI  - Notes and News.

PMID- 29837306
TI  - Dermatology.

PMID- 29837307
TI  - Antiseptics in Lying-In Hospitals.

PMID- 29837308
TI  - The Story of the Insane from Year to Year.

PMID- 29837310
TI  - The Pathological Society.

PMID- 29837309
TI  - Child Life under Queen Victoria: II. Textile Factories: the Children's Wrongs.

PMID- 29837311
TI  - Asylum Administration.

PMID- 29837312
TI  - Clinical Society.

PMID- 29837313
TI  - The Hospital Problem and the Prince's Fund.

PMID- 29837314
TI  - "The Hospital" Nursing Mirror.

PMID- 29837315
TI  - The Hospital Nursing Supplement.

PMID- 29837316
TI  - The Story of the Insane from Year to Year.

PMID- 29837318
TI  - New Appliances and Things Medical.

PMID- 29837317
TI  - The Thames and the Sewage.

PMID- 29837319
TI  - The Difficulties of Organising the Profession.

PMID- 29837320
TI  - Colour-Blind Sailors and the Board of Trade.

PMID- 29837321
TI  - Royal Medical and Chirurgical Society.

PMID- 29837322
TI  - Medical Society of London.

PMID- 29837323
TI  - Progress in Ophthalmology.

PMID- 29837324
TI  - Progress in Surgery.

PMID- 29837325
TI  - The Birmingham Hospital Saturday Fund.

PMID- 29837326
TI  - Hospital Expenditure-The Commissariat.

PMID- 29837327
TI  - Modern Sociology.

PMID- 29837328
TI  - Annotations.

PMID- 29837329
TI  - Notes and News.

PMID- 29837330
TI  - The Bradshaw Lecture on Subjective Sensation of Sound.

PMID- 29837331
TI  - The Medical Society.

PMID- 29837333
TI  - Nerve Study in a Nervous Age.

PMID- 29837332
TI  - A Clinical Lecture on Cancer of the Tongue.

PMID- 29837334
TI  - The Hospital Nursing Supplement.

PMID- 29837335
TI  - The Story of the Insane from Year to Year.

PMID- 29837336
TI  - The Howard Association.

PMID- 29837337
TI  - Construction Notes.

PMID- 29837339
TI  - The Harveian Society.

PMID- 29837338
TI  - Notes and News.

PMID- 29837340
TI  - Modern Sociology.

PMID- 29837341
TI  - Annotations.

PMID- 29837342
TI  - The Isolation Hospitals Act.

PMID- 29837343
TI  - Progress in Surgery.

PMID- 29837344
TI  - New Appliances and Things Medical.

PMID- 29837345
TI  - Hospital Construction.

PMID- 29837347
TI  - Progress in Surgery.

PMID- 29837346
TI  - The Livingstone College.

PMID- 29837349
TI  - Notes and News.

PMID- 29837348
TI  - New Appliances and Things Medical.

PMID- 29837352
TI  - Ringworm: Its Nature, Diagnosis, and Treatment.

PMID- 29837351
TI  - The Infirmary Question at Manchester.

PMID- 29837354
TI  - Doctors, Nurses, Patients, and Lady Priestley.

PMID- 29837353
TI  - The First Medical Peer.

PMID- 29837356
TI  - Bubonic Plague.

PMID- 29837355
TI  - Progress in Medicine.

PMID- 29837358
TI  - Annotations.

PMID- 29837357
TI  - Pathological Society.

PMID- 29837359
TI  - The Medico-Psychological Association and Their Nurses.

PMID- 29837360
TI  - "The Hospital" Nursing Mirror.

PMID- 29837361
TI  - Modern Sociology.

PMID- 29837362
TI  - New Appliances and Things Medical.

PMID- 29837364
TI  - Progress in Surgery.

PMID- 29837363
TI  - Clinical Society.

PMID- 29837366
TI  - Construction Notes.

PMID- 29837365
TI  - Modern Sociology.

PMID- 29837368
TI  - Progress in Medicine.

PMID- 29837367
TI  - The Education of the Deaf and Dumb.

PMID- 29837370
TI  - Hospital Expenditure-The Commissariat.

PMID- 29837369
TI  - Notes and News.

PMID- 29837371
TI  - The Medico-Psychological Association and Its Nurses.

PMID- 29837372
TI  - English Medicine in the Victorian Era.

PMID- 29837373
TI  - Cholera in January!

PMID- 29837375
TI  - The Story of the Insane from Year to Year.

PMID- 29837374
TI  - Ringworm: Its Nature, Diagnosis, and Treatment.

PMID- 29837376
TI  - "The Hospital" Nursing Mirror.

PMID- 29837377
TI  - Royal Medical and Chirurgical Society.

PMID- 29837378
TI  - Annotations.

PMID- 29837379
TI  - The Training of the Brain.

PMID- 29837380
TI  - Construction Notes.

PMID- 29837381
TI  - Notes and News.

PMID- 29837382
TI  - The British Parliament and the British Army.

PMID- 29837383
TI  - Indian Famine and English Hospitals.

PMID- 29837384
TI  - Progress in Medicine.

PMID- 29837385
TI  - Epidemiological Society.

PMID- 29837387
TI  - On Flat Foot and Its Treatment.

PMID- 29837386
TI  - "The Hospital" Nursing Mirror.

PMID- 29837389
TI  - Medical Society.

PMID- 29837388
TI  - Progress in Surgery.

PMID- 29837391
TI  - Annotations.

PMID- 29837390
TI  - Hospital Construction.

PMID- 29837392
TI  - Modern Sociology.

PMID- 29837393
TI  - The Mixture to Be Taken as before.

PMID- 29837394
TI  - Torture of the Dying.

PMID- 29837395
TI  - The Danger of False Teeth.

PMID- 29837396
TI  - New Appliances and Things Medical.

PMID- 29837397
TI  - The Sick in Scottish Prisons.

PMID- 29837398
TI  - Caged Children and Christian Civilisation.

PMID- 29837400
TI  - Progress in Ophthalmology.

PMID- 29837401
TI  - The Clinical Society.

PMID- 29837402
TI  - Psoriasis.

PMID- 29837404
TI  - Bimanual Examination of the Bladder.

PMID- 29837403
TI  - Notes and News.

PMID- 29837405
TI  - The Thames and the Sewage.

PMID- 29837406
TI  - Injuries of the Eye.

PMID- 29837407
TI  - The Hospital Nursing Supplement.

PMID- 29837408
TI  - Patients' Consent to Operations.

PMID- 29837410
TI  - Progress in Surgery.

PMID- 29837409
TI  - New Appliances and Things Medical.

PMID- 29837412
TI  - Modern Sociology.

PMID- 29837411
TI  - The Hospital Saturday Fund and Street Collections.

PMID- 29837413
TI  - Annotations.

PMID- 29837414
TI  - Hospital Expenditure-The Commissariat.

PMID- 29837415
TI  - Modern Sociology.

PMID- 29837416
TI  - Annotations.

PMID- 29837417
TI  - Notes and News.

PMID- 29837418
TI  - Dermatology.

PMID- 29837419
TI  - "The Hospital" Nursing Mirror.

PMID- 29837421
TI  - Construction Notes.

PMID- 29837420
TI  - On Flat Foot and Its Treatment.

PMID- 29837423
TI  - The Medico-Psychological Association and Their Nurses.

PMID- 29837422
TI  - New Appliances and Things Medical.

PMID- 29837425
TI  - The Central Hospital Board Question.

PMID- 29837424
TI  - The Sixpenny Doctor.

PMID- 29837426
TI  - Progress in Surgery.

PMID- 29837427
TI  - Royal Medical and Chirurgical Society.

PMID- 29837429
TI  - Writers' Diabetes.

PMID- 29837428
TI  - Progress in State Medicine.

PMID- 29837430
TI  - "The Hospital" Nursing Mirror.

PMID- 29837431
TI  - Ophthalmia in the Army.-A Contrast.

PMID- 29837432
TI  - The Medico-Psychological Association and Their Nurses.

PMID- 29837433
TI  - Hospital Meetings, &c.

PMID- 29837435
TI  - Annotations.

PMID- 29837434
TI  - In-Growing Toe-Nail.

PMID- 29837436
TI  - The Health of School Girls.

PMID- 29837437
TI  - Queen Victoria's Commemoration.

PMID- 29837438
TI  - Child Life under Queen Victoria: I. Preliminary: the Domestic System.

PMID- 29837439
TI  - New Appliances and Things Medical.

PMID- 29837441
TI  - Ormskirk Cottage Hospital.

PMID- 29837440
TI  - Royal Medical and Chirurgical Society.

PMID- 29837444
TI  - Progress in Surgery.

PMID- 29837442
TI  - Progress in Medicine.

PMID- 29837445
TI  - Oxygen, Ulcers, and Micrococci.

PMID- 29837446
TI  - The Toxins of Pneumonia.

PMID- 29837447
TI  - Notes and News.

PMID- 29837448
TI  - Chemistry, Real and Examinational.

PMID- 29837449
TI  - New Appliances and Things Medical.

PMID- 29837450
TI  - Hospital Expenditure-The Commissariat.

PMID- 29837452
TI  - "The Hospital" Nursing Mirror.

PMID- 29837451
TI  - Ophthalmia in the Army-A Contrast.

PMID- 29837453
TI  - The Story of the Insane from Year to Year.

PMID- 29837454
TI  - Double Orchectomy for Prostatic Enlargement.

PMID- 29837455
TI  - Progress in Medicine.

PMID- 29837456
TI  - Medical Certificates.

PMID- 29837458
TI  - Annotations.

PMID- 29837457
TI  - The Medico-Psychological Association and Their Nurses.

PMID- 29837459
TI  - Hospitals and Milkmen.

PMID- 29837460
TI  - Progress in Surgery.

PMID- 29837461
TI  - Modern Sociology.

PMID- 29837462
TI  - Dermatology.

PMID- 29837464
TI  - Practical Points.

PMID- 29837463
TI  - Hospital Meetings, &c.

PMID- 29837465
TI  - Practical Departments.

PMID- 29837466
TI  - The Pathological Society.

PMID- 29837467
TI  - End-To-End Approximation of Cut Arteries.

PMID- 29837468
TI  - Notes and News.

PMID- 29837469
TI  - Death of Sir Spencer Wells.

PMID- 29837470
TI  - Hospital Expenditure-The Commissariat.

PMID- 29837471
TI  - The Pulse.

PMID- 29837472
TI  - The Hospital.-Christmas Appeal Supplement.

PMID- 29837473
TI  - New Appliances and Things Medical.

PMID- 29837474
TI  - Progress in Medicine.

PMID- 29837475
TI  - The Bradshaw Lecture.

PMID- 29837476
TI  - Progress in Surgery.

PMID- 29837477
TI  - Modern Sociology.

PMID- 29837478
TI  - Notes and News.

PMID- 29837479
TI  - The Clinical Society.

PMID- 29837480
TI  - Could the Plague Attack England?

PMID- 29837481
TI  - The Physician, the Hospital, and the Community.

PMID- 29837482
TI  - Annotations.

PMID- 29837483
TI  - Guy's Hospital.

PMID- 29837485
TI  - "The Hospital" Nursing Mirror.

PMID- 29837486
TI  - Hospital Meetings, &c.

PMID- 29837487
TI  - Medico-Legal.

PMID- 29837488
TI  - Notes and News.

PMID- 29837489
TI  - Genu Valgum.-II.

PMID- 29837491
TI  - Annotations.

PMID- 29837490
TI  - Poisons and Poisoners: Antimony: Dr. Pritchard.

PMID- 29837492
TI  - Dr. Collie Again.

PMID- 29837493
TI  - Peace or War?

PMID- 29837495
TI  - New Methods of Treatment in Phthisis. I.-The Roussel Treatment.

PMID- 29837494
TI  - The History and Capabilities of Herbal Simples: XXXVII.-Ferns.

PMID- 29837496
TI  - Shall Nurses Cease to Be Laywomen?-IV.

PMID- 29837497
TI  - Ouida against the Physiologists.

PMID- 29837498
TI  - The Hospital Nursing Supplement.

PMID- 29837499
TI  - New Drugs, Appliances, and Things Medical: At the British Medical Association.

PMID- 29837500
TI  - Salol in Typhoid Fever.

PMID- 29837502
TI  - Everybody's Page.

PMID- 29837501
TI  - Treatment of Scarlet Fever and Diphtheria by Diniodide of Mercury.

PMID- 29837504
TI  - Dr. Thorne Thorne on Diphtheria.

PMID- 29837503
TI  - The Hospital Nursing Supplement.

PMID- 29837505
TI  - Science at the Church Congress.

PMID- 29837506
TI  - The Therapeutics of Music.

PMID- 29837508
TI  - Notes and News.

PMID- 29837507
TI  - Digitalis in Pneumonia.

PMID- 29837510
TI  - New Method of Treatment in Phthisis. III.-Cantharidinate of Potash.

PMID- 29837509
TI  - Talks about Food: II. The Relation of Food to Labour.

PMID- 29837511
TI  - A Peep at Russia and Home by Sweden.

PMID- 29837512
TI  - Annotations.

PMID- 29837513
TI  - Recent Investigation into the Pathology of Tetanus and the Production of Immunity
      in Animals.

PMID- 29837514
TI  - Letters from Far Japan.

PMID- 29837516
TI  - Dr. Oscar Bloch on Removal of Ovaries.

PMID- 29837515
TI  - Iritis.

PMID- 29837518
TI  - The Hospital Nursing Supplement.

PMID- 29837517
TI  - Some American Hospitals: I. Introductory.

PMID- 29837520
TI  - How Is It Done?

PMID- 29837519
TI  - New Drugs, Appliances, and Things Medical: At the British Medical Association.

PMID- 29837522
TI  - Notes and News.

PMID- 29837521
TI  - Annotations.

PMID- 29837524
TI  - Some Scientific Aspects of Insanity: VI. Early Stages.

PMID- 29837523
TI  - "Antiseptic" and "Aseptic" Surgery.

PMID- 29837526
TI  - The Bacteriology of Diphtheria.

PMID- 29837525
TI  - A Warning Outbreak.

PMID- 29837527
TI  - Everybody's Page.

PMID- 29837528
TI  - Thyroid Grafting in Myxoedema.

PMID- 29837529
TI  - The Most Interesting Hospital in the World.

PMID- 29837530
TI  - Notes and News.

PMID- 29837531
TI  - On Cerebral Haemorrhage in the Aged.

PMID- 29837532
TI  - The Hospital Nursing Supplement.

PMID- 29837533
TI  - Inside and out.

PMID- 29837535
TI  - Some Scientific Aspects of Insanity: V. Causes of Insanity.

PMID- 29837534
TI  - A Model Hospital.

PMID- 29837536
TI  - Annotations.

PMID- 29837537
TI  - Feelings and Beliefs.

PMID- 29837538
TI  - Shall Nurses Cease to Be Laywomen?-V.

PMID- 29837539
TI  - The Need for Female Factory Inspectors.

PMID- 29837541
TI  - Confusion Worse Confounded.

PMID- 29837540
TI  - New Methods of Treatment in Phthisis: II.-The Gibbes-Shurly Method.

PMID- 29837543
TI  - Scientific Scoundrelism.

PMID- 29837542
TI  - Notes and News.

PMID- 29837544
TI  - On Some Affections of the Thyroid.

PMID- 29837545
TI  - The Hospital Nursing Supplement.

PMID- 29837547
TI  - Liverpool Royal Infirmary.

PMID- 29837546
TI  - Antiseptic Treatment of Scarlet Fever.

PMID- 29837549
TI  - Annotations.

PMID- 29837548
TI  - Talks about Food: I. The Relation of Food to Labour.

PMID- 29837551
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29837550
TI  - Notes and News.

PMID- 29837553
TI  - Fogs.

PMID- 29837552
TI  - Some American Hospitals: VIII. The University of Pennsylvania Hospital.

PMID- 29837555
TI  - Everybody's Column.

PMID- 29837554
TI  - Gastric Hyperaesthesia and Acidity.

PMID- 29837557
TI  - Annotations.

PMID- 29837556
TI  - Salvationism and the Care of the Sick.

PMID- 29837559
TI  - The Ticket System.

PMID- 29837558
TI  - Some Scientific Aspects of Insanity: XIII. Dementia.

PMID- 29837560
TI  - Some American Hospitals: IX. Garfield Memorial Hospital, Washington.

PMID- 29837561
TI  - The Hospital Nursing Supplement.

PMID- 29837562
TI  - Ungrateful Patients.

PMID- 29837563
TI  - Tubercular Ulcers of the Tongue.

PMID- 29837564
TI  - A Physiologist's View of Smoking.

PMID- 29837565
TI  - The Queen and the Cold Weather.

PMID- 29837566
TI  - New Drugs, Appliances, and Things Medical: Frame Food.

PMID- 29837567
TI  - Some Scientific Aspects of Insanity: II. Brain and Spinal Cord.

PMID- 29837569
TI  - The Hospital Nursing Supplement.

PMID- 29837568
TI  - Nurses' Grievances at Glasgow.

PMID- 29837570
TI  - The Hospitals Association.

PMID- 29837572
TI  - New Methods of Treatment in Phthisis: V. Loebinger's Insufflations in Phthisis.

PMID- 29837571
TI  - The Hospitals Association.

PMID- 29837573
TI  - Amblyopia from Errors of Refraction.

PMID- 29837574
TI  - Harvest Festivals.

PMID- 29837576
TI  - Obesity: Its Causes and Treatment: II.-Treatment.

PMID- 29837575
TI  - Everybody's Page.

PMID- 29837577
TI  - Notes and News.

PMID- 29837578
TI  - Annotations.

PMID- 29837580
TI  - Talks about Food: III. How the Rich Live.

PMID- 29837579
TI  - The History and Capabilities of Herbal Simples: XXXVIII.-Feverfew.

PMID- 29837582
TI  - Everybody's Page.

PMID- 29837581
TI  - Exeunt.

PMID- 29837583
TI  - New Drugs, Appliances, and Things Medical: Newly Invented Hip Disease Chair.

PMID- 29837584
TI  - An American Sensation.

PMID- 29837586
TI  - Some Scientific Aspects of Insanity: XVI. The Insanities of the Various Periods
      of Life.

PMID- 29837585
TI  - Notes and News.

PMID- 29837588
TI  - A Persecuted Hospital.

PMID- 29837587
TI  - The Hospital Nursing Supplement.

PMID- 29837590
TI  - Treatment of Diphtheria by Sub-Membranous Injections.

PMID- 29837589
TI  - The Chloroform and Ether Controversy.

PMID- 29837591
TI  - Annotations.

PMID- 29837592
TI  - New Drugs, Appliances, and Things Medical: The Baby Carrier.

PMID- 29837593
TI  - Everybody's Page.

PMID- 29837594
TI  - Theosophy and Mrs. Besant.

PMID- 29837595
TI  - Notes and News.

PMID- 29837596
TI  - Annotations.

PMID- 29837598
TI  - The Hospital Annual.

PMID- 29837597
TI  - Ophthalmia Neonatorum.

PMID- 29837600
TI  - Medical Politics.

PMID- 29837599
TI  - Some Scientific Aspects of Insanity: I. Brain Tissue.

PMID- 29837602
TI  - Cheap Benevolence.

PMID- 29837601
TI  - Obesity: Its Causes and Treatment.

PMID- 29837603
TI  - New Methods of Treatment in Phthisis: IV.-Transfusion of the Blood of Refractory
      Animals.

PMID- 29837604
TI  - The Hospital Nursing Supplement.

PMID- 29837605
TI  - The Ordeal of Burial.

PMID- 29837607
TI  - Are All Writers Men of Genius?

PMID- 29837606
TI  - Some American Hospitals: IV. Denver.

PMID- 29837609
TI  - Everybody's Page.

PMID- 29837608
TI  - On Some Urine Tests. II.

PMID- 29837611
TI  - Some Scientific Aspects of Insanity: IX. Attention Due to Maniacs.

PMID- 29837610
TI  - The Hospital Nursing Supplement.

PMID- 29837613
TI  - Annotations.

PMID- 29837612
TI  - The Nurses' Tribute to the Dead Prince.

PMID- 29837616
TI  - The Story of the Insane from Year to Year.

PMID- 29837615
TI  - Notes and News.

PMID- 29837614
TI  - Blepharospasm.

PMID- 29837617
TI  - Notes and News.

PMID- 29837619
TI  - Annotations.

PMID- 29837618
TI  - The Most Interesting Hospital in the World.

PMID- 29837621
TI  - The Hospital Nursing Supplement.

PMID- 29837620
TI  - The Woman or the Man?

PMID- 29837623
TI  - Save Us from Our Friends.

PMID- 29837622
TI  - Old Doctors or New?

PMID- 29837625
TI  - Some Scientific Aspects of Insanity: IV. Consciousness and Mind.

PMID- 29837624
TI  - The New General Hospital at Eppendorf Hamburg.

PMID- 29837627
TI  - A Weak Spot in the Popular Religion.

PMID- 29837626
TI  - Some Modern Theories of Gout.

PMID- 29837629
TI  - The Princess of Wales and Her Son.

PMID- 29837628
TI  - Nursing Institutions.

PMID- 29837631
TI  - General Hospitals.

PMID- 29837630
TI  - A Few Other Charities.

PMID- 29837633
TI  - Notes and News.

PMID- 29837632
TI  - London without Hospitals.

PMID- 29837635
TI  - The Hospital Nursing Supplement.

PMID- 29837634
TI  - Proportionate Giving.

PMID- 29837636
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29837637
TI  - Christmas at the Hospitals.

PMID- 29837638
TI  - Everybody's Page.

PMID- 29837639
TI  - Special Hospitals.

PMID- 29837640
TI  - An Exhibition of Caterers.

PMID- 29837641
TI  - Two Pleas for Mrs. Besant.

PMID- 29837643
TI  - New Methods of Treatment in Phthisis: VI.-The Picot Method.

PMID- 29837642
TI  - On Flushing.

PMID- 29837644
TI  - A Puzzle.

PMID- 29837646
TI  - The Varieties of Lymphangitis.

PMID- 29837645
TI  - Tipping the Porter.

PMID- 29837647
TI  - Medical History from the Earliest Times: I.-Introductory.

PMID- 29837648
TI  - Annotations.

PMID- 29837650
TI  - The Increase of Diabetes.

PMID- 29837649
TI  - The Hospital Nursing Supplement.

PMID- 29837652
TI  - The Cambridge Executioner.

PMID- 29837651
TI  - Notes and News.

PMID- 29837654
TI  - The Surgical Aspect of Abdominal Tuberculosis.

PMID- 29837653
TI  - Some Scientific Aspects of Insanity: XV. Secondary Dementia.

PMID- 29837656
TI  - Overlapping.

PMID- 29837655
TI  - Notes and News.

PMID- 29837657
TI  - The Physiology of OEdema.

PMID- 29837658
TI  - Payn on Physic.

PMID- 29837659
TI  - Some American Hospitals: X. The Massachusetts General Hospital, Boston.

PMID- 29837660
TI  - Everybody's Column.

PMID- 29837661
TI  - Annotations.

PMID- 29837662
TI  - To Our Readers.

PMID- 29837664
TI  - The Hospital Nursing Supplement.

PMID- 29837663
TI  - Charity-Limited.

PMID- 29837666
TI  - Some of the Difficulties in the Diagnosis of Sarcoma of Bone.

PMID- 29837665
TI  - Foreign Bodies in the Conjunctival Sac.

PMID- 29837667
TI  - Talks about Food: V. The Staff of Life.

PMID- 29837668
TI  - Some Scientific Aspects of Insanity: XVIII. Climacteric Insanity.

PMID- 29837670
TI  - Annotations.

PMID- 29837669
TI  - The Hospital Nursing Supplement.

PMID- 29837672
TI  - Notes and News.

PMID- 29837671
TI  - Hospital Work Abroad.

PMID- 29837673
TI  - A New Method of Treatment of Diphtheria.

PMID- 29837674
TI  - Already!

PMID- 29837675
TI  - Prognosis in Cirrhosis of the Liver.

PMID- 29837676
TI  - The New and the Old.

PMID- 29837677
TI  - Recuperation.

PMID- 29837678
TI  - Everybody's Page.

PMID- 29837679
TI  - The Medical Digest.

PMID- 29837680
TI  - The Proposed Russian Famine Fund.

PMID- 29837681
TI  - New Drugs, Appliances, and Things Medical.-Addendum.

PMID- 29837682
TI  - Annotations.

PMID- 29837683
TI  - Old Doctors or New?

PMID- 29837684
TI  - New Methods of Treatment in Phthisis: VII.-The Lannelongue Treatment of
      Tubercular Joints and Bones.

PMID- 29837686
TI  - Hospitals of the North-West: I. Winnepeg and Medicine Hat.

PMID- 29837685
TI  - Notes and News.

PMID- 29837688
TI  - Everybody's Page.

PMID- 29837687
TI  - Mydriatics.

PMID- 29837689
TI  - The Antivivisection Memorial.

PMID- 29837690
TI  - The Hospital Nursing Supplement.

PMID- 29837691
TI  - A Peep at Russia, and Home by Sweden.

PMID- 29837692
TI  - Some American Hospitals: II. San Francisco.

PMID- 29837693
TI  - The Surgical Treatment of Septic Thrombosis and Other Complications of the Middle
      Ear Disease.-II.

PMID- 29837694
TI  - Obscurantism.

PMID- 29837695
TI  - Some Scientific Aspects of Insanity: VIII. The Care and Treatment of Melancholia.

PMID- 29837696
TI  - Diseases of the Arteries, Capillaries, and Veins.

PMID- 29837697
TI  - Acute Mastitis.

PMID- 29837698
TI  - Annotations.

PMID- 29837699
TI  - The Doctor's Christmas Box.

PMID- 29837700
TI  - Social Detectives.

PMID- 29837701
TI  - Notes and News.

PMID- 29837703
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29837702
TI  - Hospital Obscurantism.

PMID- 29837704
TI  - The Hospital Nursing Supplement.

PMID- 29837705
TI  - Effects of Anaemia on the Eye.

PMID- 29837707
TI  - Everybody's Page.

PMID- 29837706
TI  - The Diagnosis and Surgical Treatment of Septic Thrombosis of the Lateral Sinus.

PMID- 29837708
TI  - Annotations.

PMID- 29837709
TI  - 1891.

PMID- 29837710
TI  - English Isolation Hospitals.

PMID- 29837711
TI  - The Hospital Nursing Supplement.

PMID- 29837713
TI  - Funds and Fair-Play for the Voluntary Hospitals of London.

PMID- 29837712
TI  - New Drugs, Appliances, and Things Medical: Condensed Milk.

PMID- 29837714
TI  - Notes and News.

PMID- 29837715
TI  - The Jokes of Serious People.

PMID- 29837717
TI  - London Voluntary Hospitals and Their Critics.

PMID- 29837716
TI  - The "Pall Mall Gazette" and the Hospitals.

PMID- 29837718
TI  - Multiple Cancellous Exostoses.

PMID- 29837719
TI  - The Story of the Insane from Year to Year.

PMID- 29837721
TI  - America and Her Hospital Workers.

PMID- 29837720
TI  - Survivors.

PMID- 29837723
TI  - Some Scientific Aspects of Insanity: III. Nerve Tissue.

PMID- 29837722
TI  - Notes and News.

PMID- 29837724
TI  - Hospitals of the North-West: II. Vancouver.

PMID- 29837725
TI  - On the Question of Excision in Tubercular Hip Disease.

PMID- 29837727
TI  - Annotations.

PMID- 29837726
TI  - Professor Germane and the Medical Experts.

PMID- 29837729
TI  - The Sick in Uncivilised Lands.

PMID- 29837728
TI  - Some Points in the Treatment of Dyspepsia.

PMID- 29837731
TI  - Christianity, Editorship, and Nurses.

PMID- 29837730
TI  - The Hospital Nursing Supplement.

PMID- 29837732
TI  - The Address of the Saturday Fund Chairman.

PMID- 29837733
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29837734
TI  - The Symptoms and Treatment of Rhus Poisoning.

PMID- 29837735
TI  - The Hospital Nursing Supplement.

PMID- 29837736
TI  - Notes and News.

PMID- 29837737
TI  - Some Scientific Aspects of Insanity: XIV. Secondary Dementia.

PMID- 29837739
TI  - Suppurative Keratitis.

PMID- 29837738
TI  - Some Rays of Hope.

PMID- 29837740
TI  - Letters from Far Japan: II.-Hospitals and Medical Education. Part II.

PMID- 29837741
TI  - Annotations.

PMID- 29837742
TI  - Vivisection.

PMID- 29837743
TI  - The Hospital Saturday Fund.

PMID- 29837744
TI  - Papillomatous Ovarian Growths.

PMID- 29837746
TI  - The Hospital Sunday Fund.

PMID- 29837745
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29837747
TI  - The Story of the Insane from Year to Year.

PMID- 29837748
TI  - Letters from Far Japan.

PMID- 29837750
TI  - Annotations.

PMID- 29837749
TI  - Cactus in Functional Affections of the Heart.

PMID- 29837751
TI  - Hospital Saturday Fund.

PMID- 29837752
TI  - Everybody's Page.

PMID- 29837754
TI  - Notes and News.

PMID- 29837753
TI  - Is It English?

PMID- 29837755
TI  - Opacities of the Cornea.

PMID- 29837756
TI  - Hospital Reform.

PMID- 29837758
TI  - Popular Journalism.

PMID- 29837757
TI  - The Hospital Nursing Supplement.

PMID- 29837760
TI  - The Story of the Insane from Year to Year.

PMID- 29837759
TI  - Some Scientific Aspects of Insanity: VII. Melancholia.

PMID- 29837762
TI  - Eye Complications in Influenza.

PMID- 29837761
TI  - Some American Hospitals: Vi. The Philadelphia Hospital, Blockley.

PMID- 29837763
TI  - Annotations.

PMID- 29837764
TI  - Pegging Away.

PMID- 29837765
TI  - Gastric Dyspepsia.

PMID- 29837768
TI  - Everybody's Column.

PMID- 29837766
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29837767
TI  - Notes and News.

PMID- 29837770
TI  - The Stable Door and the Stolen Steed.

PMID- 29837769
TI  - Some Scientific Aspects of Insanity: XI. Epileptics.

PMID- 29837771
TI  - The Hospital Sunday Fund.

PMID- 29837772
TI  - Letters from Far Japan: II.-Hospitals and Medical Education in Japan. Part I.

PMID- 29837773
TI  - The Hospital Nursing Supplement.

PMID- 29837774
TI  - On a New Styptic.

PMID- 29837775
TI  - The Man of Genius.

PMID- 29837776
TI  - Everybody's Page.

PMID- 29837777
TI  - Notes and News.

PMID- 29837779
TI  - Annotations.

PMID- 29837778
TI  - The Hospital Nursing Supplement.

PMID- 29837781
TI  - No Faith in Physic.

PMID- 29837780
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29837782
TI  - Uniform Hospital Accounts.

PMID- 29837783
TI  - Some Scientific Aspects of Insanity: X. Monomania.

PMID- 29837784
TI  - Some American Hospitals: V. Military Hospitals.

PMID- 29837785
TI  - A Reflection.

PMID- 29837787
TI  - Venesection in Infantile Diseases.

PMID- 29837786
TI  - The Epidemic: Preventive Measures.

PMID- 29837788
TI  - Phlyctenular Ulceration of the Cornea.

PMID- 29837789
TI  - Some Scientific Aspects of Insanity: XII. General Paralysis.

PMID- 29837791
TI  - The Hospital Nursing Supplement.

PMID- 29837790
TI  - Everybody's Page.

PMID- 29837793
TI  - Some American Hospitals: VII. Pennsylvania Hospital.

PMID- 29837792
TI  - Intubation of the Larynx.

PMID- 29837794
TI  - New Drugs, Appliances, and Things Medical: The Invigorator Corset.

PMID- 29837795
TI  - Death in the Church.

PMID- 29837796
TI  - Notes and News.

PMID- 29837797
TI  - Inebriety and the Legislature.

PMID- 29837798
TI  - Congenital Displacement of the Hips.

PMID- 29837799
TI  - Breakers Ahead.

PMID- 29837800
TI  - The Farming of Patients.

PMID- 29837801
TI  - Annotations.

PMID- 29837802
TI  - Everybody's Page.

PMID- 29837803
TI  - Three Weeks in a Hospital.

PMID- 29837804
TI  - On Some Urinary Tests I.

PMID- 29837805
TI  - Some American Hospitals: III. Salt Lake City.

PMID- 29837806
TI  - Influenza Specifics.

PMID- 29837807
TI  - Barker's Method of Excising the Hip Joint in Tuberculous Disease.

PMID- 29837809
TI  - Writers' Brains.

PMID- 29837808
TI  - Notes and News.

PMID- 29837810
TI  - Electricity up to Date.

PMID- 29837811
TI  - Annotations.

PMID- 29837812
TI  - The Harvest of the Sick Poor.

PMID- 29837813
TI  - Diseases of the Arteries, Veins, and Capillaries.

PMID- 29837815
TI  - Some Scientific Aspects of Insanity: IX. Mania.

PMID- 29837814
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29837816
TI  - The Hospital Nursing Supplement.

PMID- 29837817
TI  - Talks about Food: IV. Sucking the Honey from the Bee.

PMID- 29837819
TI  - The Festival Season.

PMID- 29837818
TI  - Salophene.

PMID- 29837820
TI  - Everybody's Page.

PMID- 29837821
TI  - Notes and News.

PMID- 29837822
TI  - Hypnotism in America.

PMID- 29837823
TI  - Some Scientific Aspects of Insanity: XVII. The Insanities of the Puerperal State.

PMID- 29837824
TI  - Letters from Far Japan: III.-Medical Banquets.

PMID- 29837825
TI  - The Therapeutics of Oxygen Gas.

PMID- 29837826
TI  - Some Uses of Antimony.

PMID- 29837827
TI  - Annotations.

PMID- 29837828
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29837829
TI  - The Hospital Nursing Supplement.

PMID- 29837830
TI  - Some Conditions of Medical Progress.

PMID- 29837831
TI  - Hospital Meetings.

PMID- 29837833
TI  - Dilatation of the Bronchial Tubes in Children.

PMID- 29837832
TI  - British Institutions for the Care of the Inebriate-IV.

PMID- 29837834
TI  - New Appliances and Things Medical.

PMID- 29837835
TI  - Danish Medical Institutions: II. The Private Clinics.

PMID- 29837836
TI  - The Education of the Consumptive.

PMID- 29837837
TI  - Non-Medicinal Treatment of Constipation.

PMID- 29837838
TI  - The Future of St. Bartholomew's Hospital.

PMID- 29837840
TI  - Annotations.

PMID- 29837839
TI  - Infective Endocarditis.

PMID- 29837841
TI  - The Hospital. Nursing Section.

PMID- 29837842
TI  - Progress in State Medicine.

PMID- 29837844
TI  - The Future of St. Bartholomew's Hospital.

PMID- 29837843
TI  - Progress in Disease of Digestive Organs.

PMID- 29837845
TI  - The Terrible Imposture and Force of Words.

PMID- 29837846
TI  - The Physical Factors in Photo-Therapy.

PMID- 29837848
TI  - Construction Notes.

PMID- 29837847
TI  - Progress in Neurology.

PMID- 29837849
TI  - Notes and News.

PMID- 29837850
TI  - Adherent Pericardium.

PMID- 29837852
TI  - The Future of St. Bartholomew's Hospital.

PMID- 29837851
TI  - King's College Hospital Removal Fund.

PMID- 29837854
TI  - The Food of the People.

PMID- 29837853
TI  - New Appliances and Things Medical.

PMID- 29837856
TI  - The Hospital. Nursing Section.

PMID- 29837855
TI  - Visits to Private Asylums.

PMID- 29837858
TI  - Progress in Psychiatry.

PMID- 29837857
TI  - Respiratory Diseases.

PMID- 29837860
TI  - Annotations.

PMID- 29837859
TI  - Cancer of the Prostate.

PMID- 29837861
TI  - Congenital Hypertrophic Stenosis of the Pylorus.

PMID- 29837862
TI  - The Treatment of Uterine Fibroids.

PMID- 29837863
TI  - Notes and News.

PMID- 29837864
TI  - Progress in Neurology.

PMID- 29837865
TI  - The Crisis at St. Bartholomew's Hospital.

PMID- 29837866
TI  - Dr. Otto Schmidt's Specific Treatment of Cancer.

PMID- 29837867
TI  - Progress in Nerve Surgery.

PMID- 29837868
TI  - Chronic Nephritis without Albuminuria.

PMID- 29837869
TI  - Annotations.

PMID- 29837870
TI  - Improvements at Charing Cross Hospital.

PMID- 29837871
TI  - Glances at the Hospitals.

PMID- 29837872
TI  - Roman Catholic Inebriates and Their Religion.

PMID- 29837873
TI  - Treatment of Addison's Disease.

PMID- 29837874
TI  - Pathology of Gall-Stones.

PMID- 29837876
TI  - The Value of Blood Examinations in Appendicitis.

PMID- 29837875
TI  - British Institutions for the Care of the Inebriate.-II.

PMID- 29837877
TI  - The Science and the Art of Feeding.

PMID- 29837878
TI  - Enlarged Tonsils.

PMID- 29837879
TI  - Rise and Growth of Vaccination Law.-II.

PMID- 29837880
TI  - Progress in Phototherapy and Electro-Therapeutics.

PMID- 29837881
TI  - Progress in Surgery of the Stomach.

PMID- 29837882
TI  - Notes and News.

PMID- 29837883
TI  - The Hospital. Nursing Section.

PMID- 29837884
TI  - New Appliances and Things Medical.

PMID- 29837885
TI  - Intra-Cranial Abscess and Middle Ear Disease.

PMID- 29837886
TI  - Around the Hospitals.

PMID- 29837887
TI  - Notes and News.

PMID- 29837888
TI  - Modern Sociology.

PMID- 29837889
TI  - Food and Taxation.

PMID- 29837890
TI  - Research and Post-Graduate Study in Medicine.

PMID- 29837891
TI  - British Institutions for the Care of the Inebriate.-III.

PMID- 29837893
TI  - The Hospital. Nursing Section.

PMID- 29837892
TI  - Modern Hospital and Institutional Fittings.-I.

PMID- 29837894
TI  - The First Garden City.

PMID- 29837895
TI  - Progress in State Medicine.

PMID- 29837896
TI  - The Treatment of Diabetes.

PMID- 29837898
TI  - Gonorrhoeal Arthritis and Ophthalmia Neo-Natorum.

PMID- 29837897
TI  - Annotations.

PMID- 29837900
TI  - Paroxysmal Haemoglobinuria.

PMID- 29837899
TI  - New Appliances and Things Medical.

PMID- 29837901
TI  - Progress in Surgery of the Liver and Gall Bladder.

PMID- 29837902
TI  - Progress in Opthalmology.

PMID- 29837903
TI  - Gangrene of the Leg Following Pneumonia.

PMID- 29837904
TI  - The Mount Vernon Hospital for Consumption.

PMID- 29837905
TI  - The Hospital. Nursing Section.

PMID- 29837906
TI  - Urinary Casts.

PMID- 29837907
TI  - Notes and News.

PMID- 29837908
TI  - Progress in Genito-Urinary Surgery.

PMID- 29837909
TI  - A Public Health Minister.

PMID- 29837910
TI  - Tumours of the Bladder.

PMID- 29837912
TI  - Notification in Tuberculosis.

PMID- 29837911
TI  - Progress in Bacteriology.

PMID- 29837913
TI  - Materia Medica and the Medical Curriculum.

PMID- 29837914
TI  - Roman Catholic Inebriates and Their Religion.

PMID- 29837915
TI  - The Royal Waterloo Hospital for Women and Children.

PMID- 29837916
TI  - St. Bartholomew's Hospital and the Nation.

PMID- 29837917
TI  - The Ultimate Results Obtained in the Open-Air Treatment of Pulmonary
      Tuberculosis.

PMID- 29837919
TI  - New Appliances and Things Medical.

PMID- 29837918
TI  - Annotations.

PMID- 29837920
TI  - Progress in State Medicine.

PMID- 29837921
TI  - Diffuse Gonococcus Infection.

PMID- 29837923
TI  - The Elimination of the Inebriate.

PMID- 29837922
TI  - The Kelling Sanatorium, Holt, Norfolk.

PMID- 29837924
TI  - The Hospital. Nursing Section.

PMID- 29837925
TI  - The King Edward VII. Sanatorium.

PMID- 29837926
TI  - Progress in Psychiatry.

PMID- 29837927
TI  - Dislocation of the Outer End of the Clavicle.

PMID- 29837929
TI  - Respiratory Diseases.

PMID- 29837928
TI  - Modern Sociology.

PMID- 29837931
TI  - Difficulty in Swallowing.

PMID- 29837930
TI  - Modern Hospital and Institutional Fittings.-II.

PMID- 29837932
TI  - Food: Cooking and Catering.

PMID- 29837933
TI  - Perforation of the Colon by Small Foreign Bodies.

PMID- 29837934
TI  - Annotations.

PMID- 29837935
TI  - Feeding and Disease.

PMID- 29837936
TI  - The Care of Rheumatic Children.

PMID- 29837937
TI  - The Use of Copper in Syphilis.

PMID- 29837939
TI  - Notes and News.

PMID- 29837938
TI  - Rise and Growth of Vaccination Law.-III.

PMID- 29837941
TI  - Progress in Disease of Digestive Organs.

PMID- 29837940
TI  - Progress in Medicine.

PMID- 29837942
TI  - Annotations.

PMID- 29837943
TI  - Food Adulteration in 1902.

PMID- 29837945
TI  - Progress in Bacteriology.

PMID- 29837944
TI  - Modern Sociology.

PMID- 29837946
TI  - Macroglossia.

PMID- 29837947
TI  - The Future of St. Bartholomew's Hospital.

PMID- 29837948
TI  - Progress in State Medicine.

PMID- 29837949
TI  - Infective Endocarditis.

PMID- 29837950
TI  - Ethyl Chloride as a General Anaesthetic.

PMID- 29837951
TI  - New Appliances and Things Medical.

PMID- 29837952
TI  - Operative Treatment of Tuberculous Glands in the Neck.

PMID- 29837954
TI  - St. Bartholomew's Hospital.

PMID- 29837953
TI  - The Hospital. Nursing Section.

PMID- 29837955
TI  - The Uniform System of Accounts for Hospitals and Institutions.

PMID- 29837956
TI  - British Institutions for the Care of the Inebriate-V.

PMID- 29837958
TI  - Notes and News.

PMID- 29837957
TI  - The Treatment of Nephritis.

PMID- 29837959
TI  - Post-Graduation Teaching in London.

PMID- 29837960
TI  - King's College Hospital.

PMID- 29837961
TI  - Notes and News.

PMID- 29837962
TI  - Danish Medical Institutions.

PMID- 29837964
TI  - Hachish in the Old Testament.

PMID- 29837963
TI  - Progress in Surgery of the Liver and Gall Bladder.

PMID- 29837965
TI  - Ankylostomiasis in Cornwall.

PMID- 29837966
TI  - Progress in Phototherapy and Electro-Therapeutics.

PMID- 29837968
TI  - The Hospital. Nursing Section.

PMID- 29837967
TI  - Progress in Nerve Surgery.

PMID- 29837970
TI  - Cardiac Aneurysms.

PMID- 29837969
TI  - New Appliances and Things Medical.

PMID- 29837971
TI  - Glances at the Hospitals.

PMID- 29837972
TI  - King's College Hospital.

PMID- 29837974
TI  - Operation in Carcinoma of the Breast.

PMID- 29837973
TI  - Carbolic Acid and the Treatment of Plague.

PMID- 29837976
TI  - Annotations.

PMID- 29837975
TI  - Typhoid Fever in Infancy and Childhood.

PMID- 29837978
TI  - The Cost of Small-Pox.

PMID- 29837977
TI  - The Surgical Treatment of Colitis.

PMID- 29837979
TI  - Progress in Surgery of the Stomach.

PMID- 29837980
TI  - The Sunderland Union Infirmary.

PMID- 29837981
TI  - Notes and News.

PMID- 29837982
TI  - The Hospital. Nursing Section.

PMID- 29837983
TI  - New Appliances and Things Medical.

PMID- 29837984
TI  - Post Typhoid Sepsis.

PMID- 29837985
TI  - The Urban Treatment of Surgical Tuberculosis.

PMID- 29837986
TI  - Medical Teaching in the Fifteenth Century.

PMID- 29837987
TI  - Progress in Dermatology.

PMID- 29837988
TI  - Cerebro-Spinal Fluid in General Paralysis.

PMID- 29837989
TI  - The Public Health and the Duty of the Daily Press.

PMID- 29837990
TI  - Annotations.

PMID- 29837991
TI  - Glances at the Hospitals.

PMID- 29837992
TI  - Progress in Surgery of the Pancreas and Spleen.

PMID- 29837993
TI  - Danish Medical Institutions: I. The Finsen Institute.

PMID- 29837994
TI  - When to Operate in Cleft Palate.

PMID- 29837996
TI  - Visits to Private Asylums.

PMID- 29837995
TI  - The Progress of Cancer Research.

PMID- 29837997
TI  - Progress in Phototherapy and Electro-Therapeutics.

PMID- 29837998
TI  - The Prevention of Heart Disease in Children.

PMID- 29837999
TI  - New Appliances and Things Medical.

PMID- 29838000
TI  - Progress in Genito-Urinary Surgery.

PMID- 29838001
TI  - Modern Sociology.

PMID- 29838002
TI  - The Physiological Limits of Motor Speed.

PMID- 29838004
TI  - Finsen Light.

PMID- 29838003
TI  - Organacidia Gastrica.

PMID- 29838005
TI  - Acute Infantile Bronchopneumonia.

PMID- 29838006
TI  - Progress in Surgery of the Brain and Nerves.

PMID- 29838007
TI  - Finsen Light.

PMID- 29838008
TI  - A Popular Drug.

PMID- 29838010
TI  - Notes and News.

PMID- 29838009
TI  - Annotations.

PMID- 29838011
TI  - Disinfection.

PMID- 29838012
TI  - Editor's Letter-Box.

PMID- 29838013
TI  - Temperance and Education.

PMID- 29838014
TI  - Chemical Physiology.

PMID- 29838015
TI  - Progress in Skin Diseases.

PMID- 29838016
TI  - Beriberi.

PMID- 29838017
TI  - The Law Relating to Infectious Diseases.-VI.

PMID- 29838018
TI  - The Hospital. Nursing Section.

PMID- 29838019
TI  - Progress in Genito-Urinary Surgery.

PMID- 29838020
TI  - Progress in Ophthalmology.

PMID- 29838021
TI  - An Educational Problem.

PMID- 29838022
TI  - Bronchoscopy.

PMID- 29838023
TI  - New Appliances and Things Medical.

PMID- 29838024
TI  - The British Medical Association.

PMID- 29838026
TI  - The Treatment of Inoperable Cancer.

PMID- 29838025
TI  - Infant Feeding.

PMID- 29838027
TI  - Modern Sociology.

PMID- 29838028
TI  - Progress in Skin Diseases.

PMID- 29838029
TI  - Notes and News.

PMID- 29838030
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29838032
TI  - Lead Poisoning.

PMID- 29838031
TI  - The Hospital. Nursing Section.

PMID- 29838034
TI  - Annotations.

PMID- 29838033
TI  - Dilatation of the Stomach.

PMID- 29838035
TI  - The Manchester Royal Infirmary.

PMID- 29838036
TI  - Tottenham Hospital.

PMID- 29838037
TI  - The West London Hospital.

PMID- 29838038
TI  - Hospital for Sick Children, Great Ormond Street.

PMID- 29838039
TI  - The Miller Hospital.

PMID- 29838040
TI  - Royal Hospital for Diseases of the Chest, City Road.

PMID- 29838041
TI  - The Royal Orthopaedic Hospital.

PMID- 29838042
TI  - The Surgical Treatment of Irremovable Cancer of the Uterus.

PMID- 29838043
TI  - The Hospital. Nursing Section.

PMID- 29838044
TI  - No Flies.

PMID- 29838045
TI  - Universal Revaccination.

PMID- 29838046
TI  - The Law Relating to Infectious Diseases.-III.

PMID- 29838047
TI  - Therapeutic Uses of Normal Saline.

PMID- 29838049
TI  - Annotations.

PMID- 29838048
TI  - The Etiology of Chronic Nephritis.

PMID- 29838051
TI  - Progress in Genito-Urinary Surgery.

PMID- 29838050
TI  - Dermatitis Caused by Plants.

PMID- 29838053
TI  - Progress in State Medicine.

PMID- 29838052
TI  - New Appliances and Things Medical.

PMID- 29838054
TI  - Anomalous Cases of Tabes Dorsalis.

PMID- 29838055
TI  - Notes and News.

PMID- 29838056
TI  - Progress in Neurology.

PMID- 29838057
TI  - The Royal Hospital of the Innocents.

PMID- 29838058
TI  - The Story of the Insane from Year to Year.

PMID- 29838059
TI  - Posterior Drainage in Gunshot Wounds of the Abdomen.

PMID- 29838061
TI  - Progress in Cancer.

PMID- 29838060
TI  - Enterectomy Contrasted with Artificial Anus.

PMID- 29838063
TI  - Bonesetters and Their Methods.

PMID- 29838062
TI  - Annotations.

PMID- 29838065
TI  - Mount Vernon Hospital.

PMID- 29838064
TI  - Victoria Hospital, Folkestone.

PMID- 29838067
TI  - Anti-Vivisection Methods.

PMID- 29838066
TI  - The Midwives Bill.

PMID- 29838068
TI  - Modern Sociology.

PMID- 29838069
TI  - National Hospital for the Paralysed and Epileptic.

PMID- 29838070
TI  - Hospital Floors.

PMID- 29838071
TI  - The Diagnosis of Appendicitis.

PMID- 29838072
TI  - Progress in Surgery of the Pancreas and Spleen.

PMID- 29838073
TI  - The Story of the Insane from Year to Year.

PMID- 29838074
TI  - The Hospital. Nursing Section.

PMID- 29838075
TI  - Notes and News.

PMID- 29838077
TI  - Patent Foods.

PMID- 29838076
TI  - The Diagnosis of Cancer of the Uterus.

PMID- 29838078
TI  - Variola and Varicella.

PMID- 29838079
TI  - The New Hospital for Women.

PMID- 29838080
TI  - Progress in Renal Diseases.

PMID- 29838081
TI  - National Hospital for the Paralysed and Epileptic.

PMID- 29838082
TI  - Diagnostic Tapping of the Chest.

PMID- 29838083
TI  - Tonsillotomy.

PMID- 29838084
TI  - Notes and News.

PMID- 29838085
TI  - Trades Unionism in High Places.

PMID- 29838087
TI  - Arsenic in the Human Body.

PMID- 29838086
TI  - Annotations.

PMID- 29838088
TI  - The Treatment of Insomnia by Drugs.

PMID- 29838089
TI  - Special Hospital Sunday Supplement.

PMID- 29838090
TI  - The Midwives Bill.

PMID- 29838091
TI  - The King's Hospital Fund-The Coronation Gift.

PMID- 29838092
TI  - Surgery of the Peritoneum, Etc.

PMID- 29838093
TI  - Progress in Surgery.

PMID- 29838094
TI  - Progress in Bacteriology.

PMID- 29838095
TI  - Hydrophobia in South Wales.

PMID- 29838096
TI  - Ether v. Chloroform.

PMID- 29838097
TI  - Retroflexion of the Uterus.

PMID- 29838098
TI  - Hospital Sunday.

PMID- 29838099
TI  - New Appliances and Things Medical.

PMID- 29838100
TI  - Editor's Letter-Box.

PMID- 29838101
TI  - Middlesex Hospital.

PMID- 29838103
TI  - The Hospital. Nursing Section.

PMID- 29838102
TI  - The London Hospital.

PMID- 29838104
TI  - The London Hospitals: Messages from Great Personages.

PMID- 29838105
TI  - Inaccuracy of Language.

PMID- 29838107
TI  - Progress in Diseases of the Blood.

PMID- 29838106
TI  - The London Lock Hospital.

PMID- 29838109
TI  - Electrolysis for the Removal of Superfluous Hairs.

PMID- 29838108
TI  - Progress in Bacteriology.

PMID- 29838111
TI  - The Hospital. Nursing Section.

PMID- 29838110
TI  - The Seton.

PMID- 29838112
TI  - Annotations.

PMID- 29838113
TI  - Notes and News.

PMID- 29838114
TI  - St. Mark's Hospital.

PMID- 29838115
TI  - London Fever Hospital.

PMID- 29838116
TI  - Hyoscine in Paralysis Agitans.

PMID- 29838117
TI  - Progress in Ophthalmology.

PMID- 29838118
TI  - The Dangers of Arsenic.

PMID- 29838119
TI  - New Appliances and Things Medical.

PMID- 29838120
TI  - The Innocent Victims of a Conscience Clause.

PMID- 29838121
TI  - The Dietetic Value of Pasteurised Milk.

PMID- 29838122
TI  - King's College Hospital.

PMID- 29838123
TI  - Naughty Children.

PMID- 29838124
TI  - Health or Fashion?

PMID- 29838125
TI  - The Royal Orthopaedic Hospital.

PMID- 29838126
TI  - Metallic Mercury as a Purgative.

PMID- 29838127
TI  - Progress in Ophthalmology.

PMID- 29838128
TI  - Progress in Cancer.

PMID- 29838129
TI  - Gordon Hospital.

PMID- 29838130
TI  - Chloroform Administration.

PMID- 29838131
TI  - Notes and News.

PMID- 29838132
TI  - The Hospital. Nursing Section.

PMID- 29838133
TI  - Metropolitan Hospital.

PMID- 29838134
TI  - St. George's Hospital.

PMID- 29838135
TI  - Habits.

PMID- 29838137
TI  - Chronic Suppuration of the Antrum.

PMID- 29838136
TI  - "Conservative" Obstetrics.

PMID- 29838138
TI  - West London Hospital.

PMID- 29838139
TI  - The Localisation of the Mental Faculties.

PMID- 29838140
TI  - Abiotrophy.

PMID- 29838141
TI  - The Treatment of Bronchiectasis.

PMID- 29838143
TI  - A Climax at Torbay Hospital.

PMID- 29838142
TI  - New Appliances and Things Medical.

PMID- 29838144
TI  - Thyrotomy.

PMID- 29838145
TI  - Progress in Fevers.

PMID- 29838146
TI  - The Samaritan Free Hospital.

PMID- 29838147
TI  - Annotations.

PMID- 29838148
TI  - The Metropolitan Hospital Sunday Fund.

PMID- 29838149
TI  - Voice Strain in Teachers.

PMID- 29838150
TI  - Progress in Ophthalmology.

PMID- 29838151
TI  - Pyrexia in the Puerperium.

PMID- 29838152
TI  - The Spa Physician.

PMID- 29838153
TI  - Notes and News.

PMID- 29838155
TI  - Where to Vaccinate.

PMID- 29838154
TI  - Progress in Genito-Urinary Surgery.

PMID- 29838156
TI  - An Example of Compulsory Vaccination.

PMID- 29838157
TI  - The Hospital. Nursing Section.

PMID- 29838158
TI  - The Miller Hospital, Greenwich.

PMID- 29838159
TI  - New Appliances and Things Medical.

PMID- 29838160
TI  - Cardiac Failure in Diphtheria.

PMID- 29838161
TI  - The Subcutaneous Injection of Paraffin in the Treatment of Saddle Nose.

PMID- 29838162
TI  - Modern Sociology.

PMID- 29838163
TI  - The Quiescent Period in Acute Abdominal Affections.

PMID- 29838164
TI  - Cancer Research.

PMID- 29838165
TI  - Bile Burns.

PMID- 29838166
TI  - Annotations.

PMID- 29838167
TI  - Progress in Bacteriology.

PMID- 29838168
TI  - The Story of the Insane from Year to Year.

PMID- 29838169
TI  - Royal Orthopaedic Hospital.

PMID- 29838170
TI  - Paddington Green Children's Hospital.

PMID- 29838171
TI  - Glances at the Hospitals.

PMID- 29838173
TI  - Degrees and Diplomas.

PMID- 29838172
TI  - Leucocytosis in Appendicitis.

PMID- 29838174
TI  - The Medical Curriculum.

PMID- 29838175
TI  - Methylated Spirit Drinking.

PMID- 29838176
TI  - Our Inconsistencies.

PMID- 29838177
TI  - Annotations.

PMID- 29838178
TI  - The Medical Schools.

PMID- 29838179
TI  - Rupture of the Perineum.

PMID- 29838180
TI  - When Does Labour Begin?

PMID- 29838181
TI  - Banti's Disease.

PMID- 29838182
TI  - The Study of Medicine.

PMID- 29838183
TI  - Industrial Phthisis.

PMID- 29838184
TI  - Notes and News.

PMID- 29838185
TI  - The Misuse of Glasses.

PMID- 29838186
TI  - New Appliances and Things Medical.

PMID- 29838187
TI  - Progress in Fevers.

PMID- 29838188
TI  - Progress in X-Ray Therapeutics.

PMID- 29838189
TI  - The Hospital. Nursing Section.

PMID- 29838190
TI  - Progress in Neurology.

PMID- 29838191
TI  - Glances at the Hospitals.

PMID- 29838193
TI  - Progress in Anaesthetics.

PMID- 29838192
TI  - Hospital Floors.

PMID- 29838194
TI  - Advertising in Its Various Grades.

PMID- 29838195
TI  - The Hospital. Nursing Section.

PMID- 29838196
TI  - Acute Septic Arthritis of the Knee.

PMID- 29838197
TI  - Progress in Bacteriology.

PMID- 29838198
TI  - New Appliances and Things Medical.

PMID- 29838199
TI  - The Story of the Insane from Year to Year.

PMID- 29838201
TI  - Pineapple Juice in Medicine.

PMID- 29838200
TI  - The Treatment of Tuberculous Peritonitis.

PMID- 29838202
TI  - Annotations.

PMID- 29838203
TI  - Notes and News.

PMID- 29838205
TI  - An Experiment in Regard to Cancer.

PMID- 29838204
TI  - Clinical Lecture on Tubal Abortion.

PMID- 29838206
TI  - Displacement of Tendons.

PMID- 29838207
TI  - Diet in Typhoid Fever.

PMID- 29838208
TI  - Progress in Surgery of the Liver and Gall Bladder.

PMID- 29838209
TI  - The Law Relating to Infectious Diseases.-I.

PMID- 29838210
TI  - The School Nurses' Society.

PMID- 29838211
TI  - Our Sham Civilisation.

PMID- 29838212
TI  - Progress in Surgery of the Intestines.

PMID- 29838213
TI  - New Appliances and Things Medical.

PMID- 29838214
TI  - Charing Cross Hospital.

PMID- 29838216
TI  - A New Way of Fixing the Kidney.

PMID- 29838215
TI  - Trypanosoma.

PMID- 29838217
TI  - The Hospital. Nursing Section.

PMID- 29838218
TI  - The Story of the Insane from Year to Year.

PMID- 29838219
TI  - Anti-Vivisection Methods.

PMID- 29838220
TI  - Progress of the Surgery of the Vermiform Appendix.

PMID- 29838222
TI  - King's College Hospital.

PMID- 29838221
TI  - Problems in Cancer.

PMID- 29838223
TI  - The Royal Sea-Bathing Hospital, Margate.

PMID- 29838224
TI  - Exercise in Heart Disease.

PMID- 29838225
TI  - Annotations.

PMID- 29838226
TI  - American Views on the Treatment of Appendicitis.

PMID- 29838228
TI  - Appendicitis.

PMID- 29838229
TI  - Notes and News.

PMID- 29838227
TI  - The King's Illness.

PMID- 29838230
TI  - Progress in Cancer.

PMID- 29838231
TI  - Amputation at the Hip Joint.

PMID- 29838232
TI  - Notes and News.

PMID- 29838233
TI  - The Holidays.

PMID- 29838234
TI  - Addenbrooke's Hospital, Cambridge.

PMID- 29838235
TI  - Spasmodic Dysmenorrhoea.

PMID- 29838237
TI  - Modern Sociology.

PMID- 29838236
TI  - His Majesty and the Hospitals.

PMID- 29838238
TI  - Annotations.

PMID- 29838239
TI  - The Treatment of Gall Stones.

PMID- 29838240
TI  - British Home and Hospital for Incurables, Streatham.

PMID- 29838241
TI  - Progress in State Medicine.

PMID- 29838243
TI  - A Modern Lettre De Cachet.

PMID- 29838242
TI  - Progress in Genito-Urinary Surgery.

PMID- 29838245
TI  - Ovarian Dysmenorrhoea.

PMID- 29838244
TI  - North-Eastern Hospital for Children.

PMID- 29838246
TI  - King Edward's Hospital Fund.

PMID- 29838247
TI  - New Appliances and Things Medical.

PMID- 29838248
TI  - The Treatment of Naevi by Electricity.

PMID- 29838249
TI  - Malaria in England.

PMID- 29838250
TI  - Progress in General Surgery.

PMID- 29838251
TI  - Editor's Letter-Box.

PMID- 29838252
TI  - The Hospital. Nursing Section.

PMID- 29838253
TI  - Operation in Breast Cancer.

PMID- 29838254
TI  - The Story of the Insane from Year to Year.

PMID- 29838255
TI  - Annotations.

PMID- 29838256
TI  - Oowana: A New Toilet Soap.

PMID- 29838257
TI  - Summer Diarrhoea.

PMID- 29838258
TI  - New Appliances and Things Medical.

PMID- 29838259
TI  - Plague as a Soil Infection.

PMID- 29838260
TI  - Hospital Expenditure.-II.

PMID- 29838261
TI  - Notes and News.

PMID- 29838262
TI  - Modern Sociology.

PMID- 29838263
TI  - Epilepsy and Crime.

PMID- 29838265
TI  - Practical Departments.

PMID- 29838264
TI  - Health Resorts.

PMID- 29838266
TI  - Give Him Air; He'll Straight Be Well.

PMID- 29838267
TI  - The Hospital. Nursing Section.

PMID- 29838269
TI  - Progress in Orthopaedic Surgery.

PMID- 29838268
TI  - Electrical Treatment of Abdominal Viscera.

PMID- 29838270
TI  - Weather and Mortality.

PMID- 29838271
TI  - Transperitoneal Ligature of the Internal Iliac Artery.

PMID- 29838272
TI  - Progress in State Medicine.

PMID- 29838273
TI  - Glances at the Hospitals.

PMID- 29838274
TI  - Arsenic and Cancer.

PMID- 29838275
TI  - The Hospital. Nursing Section.

PMID- 29838277
TI  - The Story of the Insane from Year to Year.

PMID- 29838276
TI  - Progress in Surgery of the Liver and Gall Bladder.

PMID- 29838278
TI  - Treatment of Obstructed Labour.

PMID- 29838279
TI  - Mosquitos and Sea-Borne Malaria.

PMID- 29838280
TI  - New Appliances and Things Medical.

PMID- 29838281
TI  - Heterogenesis.

PMID- 29838282
TI  - Annotations.

PMID- 29838283
TI  - Convalescence after Appendicitis.

PMID- 29838284
TI  - Notes and News.

PMID- 29838285
TI  - Progress in Obstetrics.

PMID- 29838287
TI  - Whooping Cough Statistics.

PMID- 29838286
TI  - Modern Sociology.

PMID- 29838289
TI  - Early Mental Cases.

PMID- 29838288
TI  - Progress in Ophthalmology.

PMID- 29838290
TI  - The Hospital of St. Francis.

PMID- 29838291
TI  - The Midwives of the Future.

PMID- 29838292
TI  - Practical Department.

PMID- 29838293
TI  - Leucocytosis in Appendicitis.

PMID- 29838294
TI  - The Medical, Surgical, and Hygienic Exhibition.

PMID- 29838295
TI  - Punctuality in Infant Feeding.

PMID- 29838297
TI  - Victoria Hospital for Children, Queen's Road, Chelsea.

PMID- 29838296
TI  - Progress in Neurology.

PMID- 29838298
TI  - Alexandra Hospital for Children with Hip Disease.

PMID- 29838299
TI  - Modern Sociology.

PMID- 29838300
TI  - The New Operating Department of the London Hospital.

PMID- 29838301
TI  - Hypnotism.

PMID- 29838302
TI  - North-Eastern Hospital for Children.

PMID- 29838303
TI  - Tenotomy in Fractures.

PMID- 29838304
TI  - Education-Past and Future.

PMID- 29838305
TI  - Blood Counting in General Practice.

PMID- 29838306
TI  - The Medical Aspects of the West Indian Islands.

PMID- 29838308
TI  - Addison's Anaemia.

PMID- 29838307
TI  - The Hospital. Nursing Section.

PMID- 29838309
TI  - Friedenheim Hospital.

PMID- 29838310
TI  - Notes and News.

PMID- 29838311
TI  - Coley's Fluid in Sarcoma.

PMID- 29838313
TI  - Surgical Uses of Linen Thread.

PMID- 29838312
TI  - Progress in Psychiatry.

PMID- 29838314
TI  - Annotations.

PMID- 29838315
TI  - Annotations.

PMID- 29838316
TI  - The General Medical Council.

PMID- 29838317
TI  - Leprosy.

PMID- 29838318
TI  - Soil and Seed.

PMID- 29838319
TI  - The Hospital. Nursing Section.

PMID- 29838320
TI  - Sham Nursing Homes.

PMID- 29838321
TI  - The Composition of Douches.

PMID- 29838323
TI  - Brompton Consumption Hospital.

PMID- 29838322
TI  - Progress in Surgery of the Stomach.

PMID- 29838324
TI  - Hospital for Sick Children.

PMID- 29838325
TI  - Progress in Surgery.

PMID- 29838326
TI  - A Case of Acquired Nerve Deafness.

PMID- 29838327
TI  - Chelsea Hospital for Women.

PMID- 29838329
TI  - The League of Mercy at Marlborough House.

PMID- 29838328
TI  - Progress in Neurology.

PMID- 29838330
TI  - Hampstead Hospital Biennial Festival Dinner.

PMID- 29838331
TI  - The Victims of the War.

PMID- 29838332
TI  - Lunacy Statistics.

PMID- 29838333
TI  - Notes and News.

PMID- 29838334
TI  - New Appliances and Things Medical.

PMID- 29838335
TI  - Arthritis Accompanying Ophthalmia Neonatorum.

PMID- 29838337
TI  - Gold Miners' Phthisis.

PMID- 29838336
TI  - Erysipelas and Puerperal Fever.

PMID- 29838338
TI  - Contract Practice.

PMID- 29838339
TI  - Paratyphoid Infections.

PMID- 29838341
TI  - The King's Chocolate.

PMID- 29838340
TI  - The London Hospitals: Messages from Great Personages.

PMID- 29838342
TI  - Lumbago and Its Counterfeits.

PMID- 29838343
TI  - Health Resorts.

PMID- 29838344
TI  - The Hospital. Nursing Section.

PMID- 29838345
TI  - The Dowsing Radiant Heat Baths.

PMID- 29838346
TI  - New Appliances and Things Medical.

PMID- 29838347
TI  - Pregnancy after Double Ovariotomy.

PMID- 29838348
TI  - Annotations.

PMID- 29838349
TI  - Progress in Psychiatry.

PMID- 29838350
TI  - The Coronation and the Weather.

PMID- 29838351
TI  - Extraneous Organisms in Vaccine Lymph.

PMID- 29838353
TI  - Progress in Neurology.

PMID- 29838352
TI  - The Chemists' Exhibition.

PMID- 29838355
TI  - Notes and News.

PMID- 29838354
TI  - Progress in Bacteriology.

PMID- 29838356
TI  - Presidential Address.

PMID- 29838358
TI  - The Hospital. Nursing Section.

PMID- 29838357
TI  - Annotations.

PMID- 29838359
TI  - Cholera in Egypt.

PMID- 29838360
TI  - The Law Relating to Infectious Diseases.-II.

PMID- 29838362
TI  - Health Resorts.

PMID- 29838361
TI  - Cancer Research.

PMID- 29838364
TI  - Progress in Diabetes.

PMID- 29838363
TI  - Notes and News.

PMID- 29838365
TI  - St. Thomas's Hospital.

PMID- 29838366
TI  - Hospital Meetings: The Hospital for Epilepsy and Paralysis.

PMID- 29838367
TI  - London Lock Hospital.

PMID- 29838368
TI  - The Address in Medicine.

PMID- 29838369
TI  - The Address in Obstetrics.

PMID- 29838370
TI  - Progress in Skin Diseases.

PMID- 29838371
TI  - Modern Sociology.

PMID- 29838372
TI  - Manchester Meeting.

PMID- 29838373
TI  - New Appliances and Things Medical.

PMID- 29838374
TI  - The Law Relating to Infectious Diseases.-IV.

PMID- 29838375
TI  - Progress in Neurology.

PMID- 29838376
TI  - Town and Village Typhoid.

PMID- 29838377
TI  - The Vital Theory of the Causation of Carcinoma.

PMID- 29838379
TI  - The Wants of the Hop-Picking Mission.

PMID- 29838378
TI  - The Hospital. Nursing Section.

PMID- 29838380
TI  - Progress in Fevers.

PMID- 29838381
TI  - Lunacy in Scotland.

PMID- 29838382
TI  - Health Resorts.

PMID- 29838383
TI  - Progress in X-Ray Therapeutics.

PMID- 29838385
TI  - The Imperial Vaccination League.

PMID- 29838384
TI  - Coxa Vara.

PMID- 29838386
TI  - Rest in Heart Disease.

PMID- 29838387
TI  - Notes and News.

PMID- 29838388
TI  - A New Use for the Appendix.

PMID- 29838389
TI  - The Chronometry of Life.

PMID- 29838390
TI  - The Story of the Insane from Year to Year.

PMID- 29838391
TI  - Annotations.

PMID- 29838392
TI  - Modern Sociology.

PMID- 29838393
TI  - Idiosyncrasy.

PMID- 29838395
TI  - Progress in Neurology.

PMID- 29838394
TI  - Practical Departments.

PMID- 29838396
TI  - Annotations.

PMID- 29838397
TI  - West Ham Hospital.

PMID- 29838398
TI  - Pyrexia and Open Air.

PMID- 29838399
TI  - The Treatment of Club Foot.

PMID- 29838400
TI  - The Hospital. Nursing Section.

PMID- 29838401
TI  - Death from the Use of Atropine Drops.

PMID- 29838402
TI  - Cancer of the Uterus.

PMID- 29838403
TI  - Fires and the Architects.

PMID- 29838404
TI  - Leprosy.

PMID- 29838405
TI  - Complete Amputation of Two Limbs.

PMID- 29838406
TI  - The Middlesex Hospital.

PMID- 29838407
TI  - Notes and News.

PMID- 29838409
TI  - Race and Physical Education.

PMID- 29838408
TI  - The Royal School for Midwives at Munich.

PMID- 29838410
TI  - New Appliances and Things Medical.

PMID- 29838411
TI  - The Midwives Bill.

PMID- 29838412
TI  - Progress in Surgery.

PMID- 29838413
TI  - Progress in State Medicine.

PMID- 29838414
TI  - The Removal of Adenoids.

PMID- 29838415
TI  - Notes and News.

PMID- 29838416
TI  - Temperature in Phthisis.

PMID- 29838417
TI  - The "Offa" Ventilator.

PMID- 29838419
TI  - Beer and Cancer.

PMID- 29838418
TI  - The Royal Army Medical Corps.

PMID- 29838420
TI  - Progress in General Surgery.

PMID- 29838421
TI  - The Radical Cure of Bunions.

PMID- 29838422
TI  - The Hospital. Nursing Section.

PMID- 29838423
TI  - Annotations.

PMID- 29838424
TI  - A Warning Concerning Drainage Tubes.

PMID- 29838425
TI  - The Choice of Operation for Prostatic Enlargement.

PMID- 29838426
TI  - Modern Sociology.

PMID- 29838428
TI  - London Homoeopathic Hospital.

PMID- 29838427
TI  - Progress in Genito-Urinary Surgery.

PMID- 29838429
TI  - Bilharzia Disease.

PMID- 29838430
TI  - The Evelina Hospital.

PMID- 29838431
TI  - Arterio-Venous Aneurysm.

PMID- 29838432
TI  - Hospital and Home for Incurable Children.

PMID- 29838434
TI  - University College Hospital.

PMID- 29838433
TI  - Progress in Neurology.

PMID- 29838435
TI  - North-Eastern Hospital for Children.

PMID- 29838436
TI  - Salt Infusion in Morphia Poisoning.

PMID- 29838437
TI  - Royal Ophthalmic Hospital.

PMID- 29838438
TI  - The Mount Vernon Hospital: Country Branch.

PMID- 29838439
TI  - The Treatment of Fever Following Delivery.-Serum Therapy in Puerperal Fever.

PMID- 29838440
TI  - Sale and Purchase of a Medical Practice.

PMID- 29838442
TI  - Perforation in Typhoid Fever.

PMID- 29838441
TI  - "The Hospital" Nursing Mirror.

PMID- 29838444
TI  - Hospital Meetings, &c.

PMID- 29838443
TI  - Institutional Questions.

PMID- 29838445
TI  - The Evolution of Cataract Extraction.

PMID- 29838446
TI  - The War.

PMID- 29838448
TI  - Searching out the Secrets of Nature.

PMID- 29838447
TI  - Diphtheria.

PMID- 29838449
TI  - Consumption in Asylums.

PMID- 29838450
TI  - Tuberculosis and Slight Ailments.

PMID- 29838452
TI  - Progress in Medicine.

PMID- 29838451
TI  - Annotations.

PMID- 29838453
TI  - The Prince of Wales's Hospital Fund for London.

PMID- 29838454
TI  - Progress in Surgery.

PMID- 29838455
TI  - New Appliances and Things Medical.

PMID- 29838456
TI  - Notes and News.

PMID- 29838458
TI  - Progress in Medicine.

PMID- 29838457
TI  - A Note on Chronic Frontal Sinusitis.

PMID- 29838459
TI  - The Treatment of Congenital Dislocation of the Hip.

PMID- 29838460
TI  - Annotations.

PMID- 29838461
TI  - The General Meetings of the British Medical Association.

PMID- 29838462
TI  - Diphtheria.

PMID- 29838463
TI  - Progress in Surgery.

PMID- 29838464
TI  - Hospital Construction.

PMID- 29838465
TI  - Modern Sociology.

PMID- 29838466
TI  - The "Map of Life."

PMID- 29838467
TI  - Vaginal Coeliotomy.

PMID- 29838468
TI  - "The Hospital" Nursing Mirror.

PMID- 29838469
TI  - Searching out the Secrets of Nature.

PMID- 29838470
TI  - The Treatment of Gunshot Wound of the Abdomen.

PMID- 29838472
TI  - New Appliances and Things Medical.

PMID- 29838471
TI  - The Medical Society.

PMID- 29838474
TI  - The Geneva Convention.

PMID- 29838473
TI  - Notes and News.

PMID- 29838475
TI  - Institutional Questions.

PMID- 29838476
TI  - Modern Sociology.

PMID- 29838477
TI  - A Hat-Pin in the Stomach.

PMID- 29838478
TI  - "The Hospital" Nursing Mirror.

PMID- 29838479
TI  - Moveable Kidney: A Cause of Hepatic Colic.

PMID- 29838480
TI  - The English Education Exhibition.

PMID- 29838482
TI  - New Appliances and Things Medical.

PMID- 29838481
TI  - The Story of the Insane from Year to Year.

PMID- 29838483
TI  - Annotations.

PMID- 29838484
TI  - The Herbert Hospital, Woolwich-A Grave Scandal.

PMID- 29838485
TI  - St. George's Hospital.

PMID- 29838486
TI  - Progress in Bacteriology.

PMID- 29838488
TI  - Progress in Medicine.

PMID- 29838487
TI  - Uric Acid.

PMID- 29838489
TI  - The Nursing of Our Soldiers.-A Serious Difficulty.

PMID- 29838490
TI  - Notes and News.

PMID- 29838491
TI  - The Treatment of Minor Epilepsy.

PMID- 29838492
TI  - The Treatment of Internal Derangement of the Knee-Joint.

PMID- 29838493
TI  - Progress in Obstetrics.

PMID- 29838494
TI  - Gonorrhoeal Ophthalmia.

PMID- 29838495
TI  - The Mechanical Hypothesis as to the Origin of Cancer.

PMID- 29838496
TI  - "The Hospital" Nursing Mirror.

PMID- 29838497
TI  - The Story of the Insane from Year to Year.

PMID- 29838498
TI  - Glances at the Hospitals.

PMID- 29838499
TI  - Progress in Ophthalmology.

PMID- 29838500
TI  - Progress in Medicine.

PMID- 29838501
TI  - Institutional Questions.

PMID- 29838503
TI  - New Appliances and Things Medical.

PMID- 29838502
TI  - Insomnia.

PMID- 29838504
TI  - The Complete Mastoid Operation.

PMID- 29838505
TI  - Notes and News.

PMID- 29838506
TI  - Arthrectomy of the Knee Joint for Tuberculous Disease.

PMID- 29838507
TI  - Annotations.

PMID- 29838508
TI  - Hospital Construction.

PMID- 29838509
TI  - Modern Sociology.

PMID- 29838510
TI  - The Treatment of Appendicitis.

PMID- 29838511
TI  - The Royal College of Surgeons of England.

PMID- 29838512
TI  - Inoculation for Typhoid Fever.

PMID- 29838513
TI  - An Excessive Dose of Sulphonal.

PMID- 29838515
TI  - Progress in Medicine.

PMID- 29838514
TI  - War and Fever.

PMID- 29838517
TI  - The Treatment of Typhoid Fever.

PMID- 29838516
TI  - Notes on Health Resorts.

PMID- 29838519
TI  - Glances at the Hospitals.

PMID- 29838518
TI  - "The Hospital" Nursing Mirror.

PMID- 29838521
TI  - Food "Preservatives."

PMID- 29838520
TI  - The War Fund.

PMID- 29838523
TI  - A Calm Editor.

PMID- 29838522
TI  - The Story of the Insane from Year to Year.

PMID- 29838525
TI  - Modern Sociology.

PMID- 29838524
TI  - Typhoid Fever without Abdominal Symptoms.

PMID- 29838526
TI  - Progress in Gynaecology.

PMID- 29838527
TI  - New Appliances and Things Medical.

PMID- 29838529
TI  - The Treatment of High Degrees of Myopia.

PMID- 29838528
TI  - Acute Appendicitis.

PMID- 29838531
TI  - Notes and News.

PMID- 29838530
TI  - Tobacco-Amblyopia.

PMID- 29838532
TI  - Skin Grafting.

PMID- 29838533
TI  - Annotations.

PMID- 29838534
TI  - Hospital Construction.

PMID- 29838535
TI  - Chemical Preservatives in Food.

PMID- 29838536
TI  - Shock.

PMID- 29838537
TI  - Hospital Reform Conference.

PMID- 29838539
TI  - Annotations.

PMID- 29838538
TI  - Progress in Medicine.

PMID- 29838541
TI  - The Medical Society.

PMID- 29838540
TI  - Insanitary Pavements.

PMID- 29838542
TI  - Progress in Ophthalmology.

PMID- 29838543
TI  - Institutional Questions.

PMID- 29838544
TI  - Racial Stamina.

PMID- 29838545
TI  - Diphtheria.

PMID- 29838546
TI  - The Stomach Tube in Practical Medicine.

PMID- 29838547
TI  - "The Hospital" Nursing Mirror.

PMID- 29838548
TI  - New Appliances and Things Medical.

PMID- 29838550
TI  - Notes and News.

PMID- 29838549
TI  - On Beri-Beri in Asylums.

PMID- 29838552
TI  - Annotations.

PMID- 29838551
TI  - Progress in Surgery.

PMID- 29838554
TI  - The Sale of Poisons.

PMID- 29838553
TI  - Modern Sociology.

PMID- 29838556
TI  - The Treatment of Pericarditis with Effusion.

PMID- 29838555
TI  - Adiposis Dolorosa.

PMID- 29838558
TI  - Expert Evidence.

PMID- 29838557
TI  - "The Hospital" Nursing Mirror.

PMID- 29838559
TI  - Appendicitis.

PMID- 29838560
TI  - Editor's Letter-Box.

PMID- 29838562
TI  - Notes and News.

PMID- 29838563
TI  - Legal Notes.

PMID- 29838561
TI  - Therapeutical Notes.

PMID- 29838564
TI  - Thoroughness in Surgery.

PMID- 29838565
TI  - Institutional Questions.

PMID- 29838566
TI  - Sympathetic Ophthalmia.

PMID- 29838567
TI  - Hospital Meetings, &c.

PMID- 29838568
TI  - Progress in Medicine.

PMID- 29838569
TI  - Puerperal Insanity.

PMID- 29838570
TI  - The Leicester Guardians.

PMID- 29838572
TI  - The Radcliffe Infirmary and Its Chaplain.

PMID- 29838571
TI  - New Appliances and Things Medical.

PMID- 29838573
TI  - The Aix-La-Chapelle Treatment of Syphilis.

PMID- 29838574
TI  - Clinical Notes on Rickets.

PMID- 29838576
TI  - "The Hospital" Nursing Mirror.

PMID- 29838575
TI  - Some Details as to Aseptic Operation.

PMID- 29838577
TI  - Anti-Plague Inoculation.

PMID- 29838578
TI  - Falmouth Sanitation.

PMID- 29838579
TI  - New Appliances and Things Medical.

PMID- 29838580
TI  - The Spread of Plague.

PMID- 29838581
TI  - Modern Sociology.

PMID- 29838582
TI  - Notes and News.

PMID- 29838583
TI  - Progress in Medicine.

PMID- 29838584
TI  - Progress in Surgery.

PMID- 29838585
TI  - Institutional Questions.

PMID- 29838586
TI  - Surgery outside the Hospitals.

PMID- 29838588
TI  - Hospital Meetings, &c.

PMID- 29838587
TI  - Annotations.

PMID- 29838589
TI  - Notes and News.

PMID- 29838590
TI  - "The Hospital" Nursing Mirror.

PMID- 29838591
TI  - The War Funds-Not by Public Subscription.

PMID- 29838592
TI  - A Fatal Omen.

PMID- 29838593
TI  - Milk Inspection in New York.

PMID- 29838594
TI  - Annotations.

PMID- 29838596
TI  - Branch Hospitals for Convalescents.

PMID- 29838595
TI  - Legislation for Midwives.

PMID- 29838598
TI  - Progress in Surgery.

PMID- 29838597
TI  - New Appliances and Things Medical.

PMID- 29838599
TI  - Old Wives' Physic.

PMID- 29838600
TI  - Hospital Meetings, &c.

PMID- 29838601
TI  - Baby Farming.

PMID- 29838602
TI  - The Midwives Bill.

PMID- 29838603
TI  - Medical Practice by Commercial Companies.

PMID- 29838604
TI  - Progress in Medicine.

PMID- 29838605
TI  - Royal Medical and Chirurgical Society.

PMID- 29838606
TI  - Prolonged Syphilitic Taint in the Ova.

PMID- 29838607
TI  - Children and Malaria.

PMID- 29838609
TI  - Artificial Menopause.

PMID- 29838608
TI  - Notes and News.

PMID- 29838611
TI  - The Forty-First Annual Report of the Commissioners in Lunacy for Scotland.

PMID- 29838610
TI  - Progress in Psychiatry.

PMID- 29838613
TI  - Metropolitan Extension.

PMID- 29838612
TI  - Institutional Questions.

PMID- 29838615
TI  - The Sanatorium Treatment of Tuberculosis.

PMID- 29838614
TI  - The Bacterial Treatment of Sewage.

PMID- 29838616
TI  - The Adulteration of Drugs.

PMID- 29838617
TI  - Diphtheria.

PMID- 29838618
TI  - Progress in Medicine.

PMID- 29838619
TI  - The Prince of Wales's Hospital Fund for London.

PMID- 29838620
TI  - Editor's Letter-Box.

PMID- 29838621
TI  - Civilisation and Obstetrics.

PMID- 29838623
TI  - Provident Dispensaries.

PMID- 29838622
TI  - New Appliances and Things Medical.

PMID- 29838625
TI  - Annotations.

PMID- 29838624
TI  - "The Hospital" Nursing Mirror.

PMID- 29838626
TI  - Koch on Malaria.

PMID- 29838627
TI  - Provident Dispensaries.

PMID- 29838629
TI  - The Flying Hospital.

PMID- 29838628
TI  - Progress in Ophthalmology.

PMID- 29838630
TI  - Hospital Construction.

PMID- 29838631
TI  - The Causes of Insanity.

PMID- 29838633
TI  - Notes and News.

PMID- 29838632
TI  - New Appliances and Things Medical.

PMID- 29838635
TI  - Progress in Surgery.

PMID- 29838634
TI  - Cerebro-Spinal Meningitis.

PMID- 29838636
TI  - The Story of the Insane from Year to Year.

PMID- 29838637
TI  - Plague in India.

PMID- 29838638
TI  - The Case of Mrs. Crook.

PMID- 29838639
TI  - Sir William Banks on the Origin of Cancer.

PMID- 29838640
TI  - "The Hospital" Nursing Mirror.

PMID- 29838641
TI  - Progress in Medicine.

PMID- 29838642
TI  - Annotations.

PMID- 29838643
TI  - Opening of the New Italian Hospital.

PMID- 29838644
TI  - Hospital Meetings, &c.

PMID- 29838645
TI  - Typhoid Fever in America.

PMID- 29838646
TI  - London Sewage.

PMID- 29838647
TI  - The Wages of Prosperity.

PMID- 29838649
TI  - The Treatment of Fractured Patella.

PMID- 29838648
TI  - Hospital Meetings, &c.

PMID- 29838651
TI  - Progress in Surgery.

PMID- 29838650
TI  - Institutional Questions.

PMID- 29838653
TI  - Notes and News.

PMID- 29838652
TI  - Surgery in Gastric Dilatation.

PMID- 29838654
TI  - The Ophthalmoscope in General Practice.

PMID- 29838655
TI  - Modern Sociology.

PMID- 29838657
TI  - Progress in Medicine.

PMID- 29838656
TI  - Massage in the Treatment of Fractures.

PMID- 29838658
TI  - "The Hospital" Nursing Mirror.

PMID- 29838659
TI  - Intermittent Painless Haematuria.

PMID- 29838660
TI  - The Moral Condition of London.

PMID- 29838661
TI  - Addenbrooke's Hospital.

PMID- 29838662
TI  - "Open Air" and Tuberculosis.

PMID- 29838663
TI  - Annotations.

PMID- 29838664
TI  - Immobilisation of the Flaps after Amputation.

PMID- 29838665
TI  - The Mortality from Influenza.

PMID- 29838666
TI  - Fighting Consumption in Manchester.

PMID- 29838667
TI  - New Appliances and Things Medical.

PMID- 29838669
TI  - Accidental Electric Shocks.

PMID- 29838668
TI  - The Treatment of Eclampsia.

PMID- 29838670
TI  - Annotations.

PMID- 29838671
TI  - Poplar Hospital for Accidents.

PMID- 29838672
TI  - Drill in Schools.

PMID- 29838673
TI  - The Disinfection of Rooms.

PMID- 29838674
TI  - London Temperance Hospital.

PMID- 29838675
TI  - Progress in State Medicine.

PMID- 29838676
TI  - Progress in Psychiatry.

PMID- 29838677
TI  - Surgery in Mitral Stenosis.

PMID- 29838678
TI  - "Motoring" for Health.

PMID- 29838679
TI  - Isolation in Scarlet Fever.

PMID- 29838680
TI  - The National Hospital for the Paralysed.

PMID- 29838681
TI  - The Treatment of Gout.

PMID- 29838682
TI  - Progress in Disease of Digestive Organs.

PMID- 29838683
TI  - Cotton-Wool Sandwiches.

PMID- 29838684
TI  - The Hospital. Nursing Section.

PMID- 29838685
TI  - Practical Departments.

PMID- 29838687
TI  - Notes and News.

PMID- 29838686
TI  - St. Peter's Hospital.

PMID- 29838688
TI  - Infants at School.

PMID- 29838689
TI  - Editor's Letter-Box.

PMID- 29838690
TI  - Scientific Education.

PMID- 29838691
TI  - The Hospital. Nursing Section.

PMID- 29838692
TI  - The Prevalence of Lunacy in England and Wales.

PMID- 29838693
TI  - The Decadence of the "Civilised" Negro.

PMID- 29838694
TI  - Alcohol, Tuberculosis, and the Public-House.

PMID- 29838695
TI  - The Story of the Insane from Year to Year.

PMID- 29838696
TI  - Placenta Praevia.

PMID- 29838697
TI  - Progress in Gynaecology.

PMID- 29838698
TI  - Glances at the Hospitals.

PMID- 29838699
TI  - An Error in the Use of Statistics.

PMID- 29838700
TI  - Modern Sociology.

PMID- 29838701
TI  - New Appliances and Things Medical.

PMID- 29838702
TI  - Liverpool Sanatorium for Consumptives.

PMID- 29838703
TI  - Notes and News.

PMID- 29838705
TI  - Anaesthetics in Short Operations on the Throat and Nose.

PMID- 29838704
TI  - Annotations.

PMID- 29838706
TI  - Progress in Genito-Urinary Surgery.

PMID- 29838707
TI  - Compulsory but Unpaid Professional Services.

PMID- 29838708
TI  - Half-Timers.

PMID- 29838709
TI  - Progress in Neurology.

PMID- 29838711
TI  - Drainage and Irrigation in Urethrotomy.

PMID- 29838710
TI  - The Law Relating to Infectious Diseases.-V.

PMID- 29838712
TI  - Institutional Questions.

PMID- 29838713
TI  - Tuberculosis in Cows.

PMID- 29838714
TI  - Erin Go Bragh.

PMID- 29838715
TI  - Progress in Medicine.

PMID- 29838716
TI  - The Artificial Feeding of Infants.-A Rational Method.

PMID- 29838717
TI  - The Late Sir Andrew Clark.

PMID- 29838718
TI  - Notes and News.

PMID- 29838719
TI  - The Prevention of Malaria.

PMID- 29838721
TI  - Working-Class Members of Hospital Committees.

PMID- 29838720
TI  - Annotations.

PMID- 29838722
TI  - The Army Medical Department.

PMID- 29838723
TI  - The Skin Affections Met with in Bright's Disease.

PMID- 29838724
TI  - Acute Rheumatism and Valvular Disease.

PMID- 29838725
TI  - Progress in Surgery.

PMID- 29838726
TI  - The "Princess Christian" Hospital.

PMID- 29838727
TI  - Legislation for Midwives.

PMID- 29838728
TI  - "The Hospital" Nursing Mirror.

PMID- 29838729
TI  - Hospital Meetings, &c.

PMID- 29838730
TI  - Progress in Surgery.

PMID- 29838731
TI  - Modern Sociology.

PMID- 29838732
TI  - Hospital Construction.

PMID- 29838733
TI  - The Sale of Food and Drugs Act, 1899.

PMID- 29838734
TI  - Annotations.

PMID- 29838735
TI  - London Sanitation.

PMID- 29838737
TI  - Progress in Medicine.

PMID- 29838736
TI  - Progress in Ophthalmology.

PMID- 29838738
TI  - Institutional Questions.

PMID- 29838739
TI  - Diet in Typhoid Fever.

PMID- 29838740
TI  - Rupture of the Uterus.

PMID- 29838741
TI  - "The Hospital" Nursing Mirror.

PMID- 29838742
TI  - The Tuberculous Convalescent.

PMID- 29838743
TI  - Excision of a Tuberculous Vesicula Seminalis.

PMID- 29838744
TI  - Notes and News.

PMID- 29838745
TI  - Influenza and Pneumonia.

PMID- 29838746
TI  - Cancer of the Penis.

PMID- 29838747
TI  - Periscope of Dermatology.

PMID- 29838748
TI  - Institutional Questions.

PMID- 29838749
TI  - Modern Sociology.

PMID- 29838750
TI  - The Story of the Insane from Year to Year.

PMID- 29838751
TI  - New Appliances and Things Medical.

PMID- 29838752
TI  - Notes and News.

PMID- 29838753
TI  - On the Value of Widal's Reaction.

PMID- 29838754
TI  - A Bullet with Low Velocity.

PMID- 29838755
TI  - Progress in Medicine.

PMID- 29838756
TI  - The General Medical Council.

PMID- 29838757
TI  - Progress in Surgery.

PMID- 29838758
TI  - The Feeding of an Army.

PMID- 29838759
TI  - High Velocity Bullets.

PMID- 29838760
TI  - The Treatment of Tinea Capitis.

PMID- 29838761
TI  - Annotations.

PMID- 29838763
TI  - Rigors.

PMID- 29838762
TI  - Notes on Health Resorts.

PMID- 29838764
TI  - "The Hospital" Nursing Mirror.

PMID- 29838765
TI  - The Diagnosis of Meningitis.

PMID- 29838767
TI  - The Cage Treatment of Superficial Wounds.

PMID- 29838766
TI  - Annotations.

PMID- 29838768
TI  - English and Foreign Spas.

PMID- 29838769
TI  - Anaesthetics and Insanity.

PMID- 29838771
TI  - Tuberculosis in Mammals and in Birds.

PMID- 29838770
TI  - Notes and News.

PMID- 29838772
TI  - New Applicances and Things Medical.

PMID- 29838773
TI  - Institutional Questions.

PMID- 29838775
TI  - A Board of Guardians Heavily Fined.

PMID- 29838774
TI  - The Lunatic Asylums of Bengal.

PMID- 29838777
TI  - The Story of the Insane from Year to Year.

PMID- 29838776
TI  - "The Hospital" Nursing Mirror.

PMID- 29838778
TI  - Sunday Entertainments.

PMID- 29838780
TI  - Itching.

PMID- 29838779
TI  - Some Plaster of Paris Splints.

PMID- 29838782
TI  - Hospital Construction.

PMID- 29838781
TI  - The Open-Air Treatment of Tuberculosis.

PMID- 29838784
TI  - Progress in Medicine.

PMID- 29838783
TI  - Vaccination Officers and Their Duties.

PMID- 29838785
TI  - Treatment of Epistaxis by a Sponge Plug.

PMID- 29838786
TI  - Enlarged Prostate.

PMID- 29838788
TI  - Typhoidette.

PMID- 29838787
TI  - The Story of the Insane from Year to Year.

PMID- 29838790
TI  - Progress in Fevers.

PMID- 29838789
TI  - The Hospital.

PMID- 29838791
TI  - Divided Sanitary Responsibility.

PMID- 29838792
TI  - Annotations.

PMID- 29838793
TI  - Fatigue as a Cause of Consumption.

PMID- 29838794
TI  - Hospital Reform in France.

PMID- 29838796
TI  - Modern Sociology.

PMID- 29838795
TI  - The Treatment of Infantile Paralysis.

PMID- 29838798
TI  - Notes and News.

PMID- 29838797
TI  - Antitoxin at Colchester.

PMID- 29838799
TI  - North-West London Hospital.

PMID- 29838800
TI  - Hospital Dispute at Torquay.

PMID- 29838801
TI  - Surgical Treatment of Gall-Stones.

PMID- 29838802
TI  - Progress in Disease of Digestive Organs.

PMID- 29838804
TI  - Amputation in the Course of Diabetes.

PMID- 29838803
TI  - Progress in Psychiatry.

PMID- 29838805
TI  - British Lying-In Hospital.

PMID- 29838806
TI  - Progress in Gynaecology.

PMID- 29838808
TI  - Doctors and Municipal Socialism.

PMID- 29838807
TI  - Modern Sociology.

PMID- 29838809
TI  - Annotations.

PMID- 29838810
TI  - Prophylactic Inoculation.

PMID- 29838811
TI  - Glances at the Hospitals.

PMID- 29838812
TI  - Extension in Pott's Disease.

PMID- 29838813
TI  - Spina Bifida.

PMID- 29838814
TI  - The Surgical Treatment of Spastic Infantile Paralysis.

PMID- 29838815
TI  - Anti-Typhoid Inoculation.

PMID- 29838816
TI  - Naso-Pharyngeal Lesions in Childhood.

PMID- 29838817
TI  - Hospital Expenditure.

PMID- 29838818
TI  - Nurses' Home at the City of Dublin Hospital.

PMID- 29838819
TI  - The London Hospital.

PMID- 29838820
TI  - The Hospital. Nursing Section.

PMID- 29838821
TI  - The Education of the Public.

PMID- 29838822
TI  - Progress in Bacteriology.

PMID- 29838823
TI  - Notes and News.

PMID- 29838824
TI  - Progress in Cancer.

PMID- 29838825
TI  - Plague in Honolulu.

PMID- 29838826
TI  - Annotations.

PMID- 29838827
TI  - Reform of the Medical Acts.

PMID- 29838828
TI  - Progress in Surgery.

PMID- 29838829
TI  - Cerebro-Spinal Meningitis.

PMID- 29838830
TI  - Myasthenia.

PMID- 29838831
TI  - Feeble-Minded Children.

PMID- 29838832
TI  - Ventilation.

PMID- 29838833
TI  - The Tenements of New York.

PMID- 29838834
TI  - "The Hospital" Nursing Mirror.

PMID- 29838835
TI  - The Origin of Cancer.

PMID- 29838836
TI  - Notes and News.

PMID- 29838837
TI  - Progress in Medicine.

PMID- 29838838
TI  - New Appliances and Things Medical.

PMID- 29838839
TI  - "Florence Warden" on Sandgate Convalescent Homes.

PMID- 29838840
TI  - St. Mark's Hospital and the Prince of Wales's Fund.

PMID- 29838842
TI  - 1900.

PMID- 29838841
TI  - Hospital Meetings, &c.

PMID- 29838843
TI  - Modern Sociology.

PMID- 29838844
TI  - Progress in State Medicine.

PMID- 29838846
TI  - Progress in Medicine.

PMID- 29838845
TI  - Dentists and the War.

PMID- 29838847
TI  - Notes and News.

PMID- 29838848
TI  - The Story of the Insane from Year to Year.

PMID- 29838849
TI  - Scurvy-Rickets and Civilisation.

PMID- 29838850
TI  - "The Hospital" Nursing Mirror.

PMID- 29838851
TI  - New Appliances and Things Medical.

PMID- 29838852
TI  - Hiccough and Its Treatment.

PMID- 29838853
TI  - Travel in the Treatment of Diseases of the Nervous System.

PMID- 29838854
TI  - Annotations.

PMID- 29838856
TI  - Hospital Construction.

PMID- 29838855
TI  - Glances at the Hospitals.

PMID- 29838857
TI  - Progress in Obstetrics.

PMID- 29838858
TI  - Gunshot Wounds of the Abdomen.

PMID- 29838859
TI  - Royal Orthopaedic Hospital.

PMID- 29838860
TI  - St. Mary's Hospital Extension.

PMID- 29838861
TI  - New Appliances and Things Medical.

PMID- 29838862
TI  - Primary Tuberculosis of the Cervix Simulating Carcinoma.

PMID- 29838863
TI  - Notes and News.

PMID- 29838864
TI  - The Influence of Acute Diseases upon Insanity.

PMID- 29838865
TI  - The Hospital. Nursing Section.

PMID- 29838866
TI  - Victoria Hospital, Folkestone.

PMID- 29838867
TI  - Hallux Valgus, or Bunion.

PMID- 29838868
TI  - Progress in Disease of Digestive Organs.

PMID- 29838869
TI  - National Sanitary Organisation.

PMID- 29838871
TI  - Malignant Endocarditis.

PMID- 29838870
TI  - Progress in Fevers.

PMID- 29838872
TI  - The Peculiar People and the Law.

PMID- 29838873
TI  - Progress in Surgery.

PMID- 29838875
TI  - Treatment of Loose Cartilage in the Knee Joint.

PMID- 29838874
TI  - The Origin of Cancer.

PMID- 29838876
TI  - Annotations.

PMID- 29838877
TI  - Health and House Warming.

PMID- 29838878
TI  - The Story of the Insane from Year to Year.

PMID- 29838879
TI  - The Saline Treatment of Dysentery.

PMID- 29838881
TI  - The Increase in the Number of the Insane.

PMID- 29838880
TI  - Mental Dissolution.

PMID- 29838882
TI  - Progress in Medicine.

PMID- 29838883
TI  - "The Hospital" Nursing Mirror.

PMID- 29838885
TI  - The Prince of Wales's Hospital Fund for London.

PMID- 29838884
TI  - Progress in Psychiatry.

PMID- 29838887
TI  - A Consultation Hospital.

PMID- 29838886
TI  - Notes and News.

PMID- 29838888
TI  - A Medical Globe-Trotter.

PMID- 29838889
TI  - The Tuberculin Test.

PMID- 29838890
TI  - Modern Sociology.

PMID- 29838891
TI  - Hospital Construction.

PMID- 29838892
TI  - Annotations.

PMID- 29838893
TI  - Therapeutical Notes.

PMID- 29838895
TI  - Malaria.

PMID- 29838894
TI  - Micro-Organisms as a Cause of Chronic Disease.

PMID- 29838897
TI  - Mauser Bullet Wounds.

PMID- 29838896
TI  - Institutional Questions.

PMID- 29838899
TI  - Annotations.

PMID- 29838898
TI  - Hospital Meetings, &c.

PMID- 29838900
TI  - The Story of the Insane from Year to Year.

PMID- 29838901
TI  - Pericardial Corns.

PMID- 29838902
TI  - The Midwives Bill.

PMID- 29838903
TI  - Micro-Organisms as a Cause of Chronic Disease.

PMID- 29838905
TI  - Progress in Medicine.

PMID- 29838904
TI  - Progress in State Medicine.

PMID- 29838907
TI  - South Africa.

PMID- 29838906
TI  - Progress in Surgery.

PMID- 29838908
TI  - "The Hospital" Nursing Mirror.

PMID- 29838909
TI  - The Dosage of Chloroform.

PMID- 29838910
TI  - Modern Sociology.

PMID- 29838911
TI  - The Results of Resection of Intestine.

PMID- 29838912
TI  - How to Gargle.

PMID- 29838913
TI  - Notes and News.

PMID- 29838915
TI  - Glances at the Hospitals.

PMID- 29838914
TI  - The Treatment of Uterine Fibroids.

PMID- 29838916
TI  - Hospital Meetings, &c.

PMID- 29838917
TI  - Glances at the Hospitals.

PMID- 29838918
TI  - Notes and News.

PMID- 29838919
TI  - Underfed Children.

PMID- 29838921
TI  - Aerated Waters.

PMID- 29838920
TI  - "The Hospital" Nursing Mirror.

PMID- 29838922
TI  - Modern Sociology.

PMID- 29838923
TI  - Progress in Surgery.

PMID- 29838925
TI  - The Treatment of Seborrhoea of the Scalp.

PMID- 29838924
TI  - The Antiseptic Instinct.

PMID- 29838926
TI  - Institutional Questions.

PMID- 29838927
TI  - The Story of the Insane from Year to Year.

PMID- 29838928
TI  - The Pathological Society.

PMID- 29838929
TI  - Some Plaster of Paris Splints.

PMID- 29838930
TI  - Headache.

PMID- 29838931
TI  - Intestinal Antiseptics.

PMID- 29838932
TI  - Sale and Purchase of a Medical Practice.

PMID- 29838933
TI  - Annotations.

PMID- 29838934
TI  - The Adulteration of Drugs.

PMID- 29838935
TI  - Progress in Medicine.

PMID- 29838936
TI  - Hospital Construction.

PMID- 29838937
TI  - Excision of the Knee-Joint.

PMID- 29838938
TI  - The Rulers of South London.

PMID- 29838939
TI  - Hospital Meetings, &c.

PMID- 29838940
TI  - Notes and News.

PMID- 29838941
TI  - The Story of the Insane from Year to Year.

PMID- 29838942
TI  - Editor's Letter-Box.

PMID- 29838943
TI  - "The Hospital" Nursing Mirror.

PMID- 29838944
TI  - English and Foreign Hospitals.

PMID- 29838945
TI  - Food Preservatives.

PMID- 29838946
TI  - Modern Sociology.

PMID- 29838947
TI  - New Appliances and Things Medical.

PMID- 29838948
TI  - Progress in Surgery.

PMID- 29838949
TI  - Wild Oats.

PMID- 29838951
TI  - Cancer of the Uterus.

PMID- 29838950
TI  - Progress in Medicine.

PMID- 29838952
TI  - Unqualified Dispensers.

PMID- 29838953
TI  - Hospital Construction.

PMID- 29838954
TI  - Annotations.

PMID- 29838955
TI  - Night-Blindness.

PMID- 29838956
TI  - Notes and News.

PMID- 29838957
TI  - Progress in Surgery.

PMID- 29838958
TI  - Diphtheria.

PMID- 29838960
TI  - The Medical Addresses.

PMID- 29838959
TI  - The Functions of a University.

PMID- 29838962
TI  - A Case of Ankylosis of Both Temporo-Maxillary Joints.

PMID- 29838961
TI  - North London Consumption Hospital.

PMID- 29838964
TI  - Notes on Health Resorts.

PMID- 29838963
TI  - Modern Sociology.

PMID- 29838965
TI  - Institutional Questions.

PMID- 29838966
TI  - Hospital Construction.

PMID- 29838968
TI  - Floating Liver.

PMID- 29838967
TI  - Recent Progress in Radiography.

PMID- 29838970
TI  - "The Hospital" Nursing Mirror.

PMID- 29838969
TI  - New Appliances and Things Medical.

PMID- 29838972
TI  - Phototherapy.

PMID- 29838971
TI  - Annotations.

PMID- 29838973
TI  - Medicine, Pharmacy, and Dispensing.

PMID- 29838974
TI  - Teetotalism and Philanthropy.

PMID- 29838975
TI  - The Decline of Tuberculosis.

PMID- 29838977
TI  - Hospital Meetings, &c.

PMID- 29838979
TI  - Chronic Rigidity of the Spine.

PMID- 29838978
TI  - Tuberculous Peritonitis.

PMID- 29838981
TI  - Therapeutical Notes.

PMID- 29838980
TI  - Progress in Psychiatry.

PMID- 29838983
TI  - "The Hospital" Nursing Mirror.

PMID- 29838982
TI  - Progress in Medicine.

PMID- 29838984
TI  - Hospital Meetings, &c.

PMID- 29838985
TI  - Impurities in London Water.

PMID- 29838987
TI  - Diphtheria.

PMID- 29838986
TI  - Annotations.

PMID- 29838989
TI  - Notes and News.

PMID- 29838988
TI  - Women on Hospital Boards.

PMID- 29838990
TI  - Prince of Wales's Hospital Fund for London.

PMID- 29838991
TI  - New Appliances and Things Medical.

PMID- 29838992
TI  - Institutional Questions.

PMID- 29838993
TI  - Puerperal Insanity.

PMID- 29838994
TI  - "Diabetic" Gangrene.

PMID- 29838995
TI  - The Christmas Season and the Dying Year.

PMID- 29838996
TI  - Cadge, of Norwich.

PMID- 29838997
TI  - Notes and News.

PMID- 29838998
TI  - Progress in Medicine.

PMID- 29838999
TI  - Addenbrooke's Hospital, Cambridge.

PMID- 29839000
TI  - Progress in Surgery.

PMID- 29839001
TI  - Institutional Questions.

PMID- 29839002
TI  - Diphtheria of the Conjunctiva.

PMID- 29839003
TI  - Legal Intelligence.

PMID- 29839005
TI  - Case-Mortality in Pneumonia.

PMID- 29839004
TI  - Military Service and National Health.

PMID- 29839007
TI  - New Appliances and Things Medical.

PMID- 29839006
TI  - The Secrecy of the Proceedings at "Committees."

PMID- 29839009
TI  - "The Hospital" Nursing Mirror.

PMID- 29839008
TI  - The Restoration of Function after Section of Nerve Trunks.

PMID- 29839010
TI  - Hospital Meetings, &c.

PMID- 29839011
TI  - The Prince of Wales's Fund and St. Mark's Hospital.

PMID- 29839012
TI  - The Proper Scope of Legislation for Midwives.

PMID- 29839013
TI  - The Indian Famine.

PMID- 29839014
TI  - Annotations.

PMID- 29839015
TI  - A New Method of Vaccination.

PMID- 29839016
TI  - Modern Sociology.

PMID- 29839017
TI  - Phthisis and Pneumonia.

PMID- 29839019
TI  - Therapeutical Notes.

PMID- 29839018
TI  - Haemopneumothorax.

PMID- 29839020
TI  - Dr. Savage on the Relation between Post-Mortem Appearances and Pathological
      Processes.

PMID- 29839021
TI  - Sir William Gowers on Premature Nervous Decay.

PMID- 29839022
TI  - The Treatment of Tabes Dorsalis.

PMID- 29839023
TI  - Annotations.

PMID- 29839024
TI  - Notes on Health Resorts.

PMID- 29839025
TI  - "The Hospital" Nursing Mirror.

PMID- 29839026
TI  - The Ownership of Sanatoria.

PMID- 29839027
TI  - Christmas Appeal Supplement.

PMID- 29839028
TI  - The Relief Funds for the War.

PMID- 29839029
TI  - Legal Notes.

PMID- 29839030
TI  - Progress in Medicine.

PMID- 29839031
TI  - Hospital Meetings, &c.

PMID- 29839033
TI  - Aneurism of the Aorta.

PMID- 29839032
TI  - Puerperal Insanity.

PMID- 29839034
TI  - Progress in Surgery.

PMID- 29839035
TI  - Notes and News.

PMID- 29839037
TI  - A New Method of Colostomy.

PMID- 29839036
TI  - Benzoic Acid and the Benzoates as Urinary Antiseptics.

PMID- 29839038
TI  - News and Events of the Week.

PMID- 29839039
TI  - The Action of Certain Drugs on the Heart.

PMID- 29839040
TI  - "The Hospital" Medico-Sociological Supplement. No. III.

PMID- 29839041
TI  - Annotations.

PMID- 29839042
TI  - New Appliances and Things Medical.

PMID- 29839044
TI  - The Week's Work.

PMID- 29839043
TI  - Institutional Notes and News.

PMID- 29839045
TI  - Nerve in Surgery.

PMID- 29839046
TI  - The Largest Hospitals.

PMID- 29839048
TI  - Eminent Chairman Series, VI. The Hon. W. F. D. Smith.

PMID- 29839047
TI  - Parliament and Publications.

PMID- 29839050
TI  - Comedo Extractor.

PMID- 29839049
TI  - Experimental Biology.

PMID- 29839051
TI  - Medical Opinion and Movement.

PMID- 29839052
TI  - Bilharziosis of the Appendix.

PMID- 29839053
TI  - The Responsibility at Law of the Parent.

PMID- 29839054
TI  - Annotations.

PMID- 29839055
TI  - The Week's Work.

PMID- 29839056
TI  - News and Events of the Week.

PMID- 29839057
TI  - The Ward Floor: I. General Considerations.

PMID- 29839058
TI  - The Operative Treatment of Fractures.

PMID- 29839059
TI  - The Proper Relation of the Superintendent to the Trustees of a Hospital.

PMID- 29839060
TI  - Gas in the Stomach and Its Treatment.

PMID- 29839061
TI  - The Thymus Treatment of Inoperable Cancer.

PMID- 29839062
TI  - The Week in the Courts.

PMID- 29839063
TI  - Hospitals and the Law in 1910.

PMID- 29839064
TI  - International Committee for Post-Graduate Medical Education.

PMID- 29839065
TI  - Drug Eruptions: Their Nature and Varieties.

PMID- 29839066
TI  - Dermatobia Noxialis.

PMID- 29839067
TI  - Medical Opinion and Movement.

PMID- 29839068
TI  - The Hospital World.

PMID- 29839069
TI  - Australian Notes.

PMID- 29839071
TI  - Institutional Notes and News.

PMID- 29839070
TI  - Parliament and Publications.

PMID- 29839072
TI  - A Year's Progress in Animal Protection.

PMID- 29839074
TI  - New Appliances and Things Medical.

PMID- 29839073
TI  - Sanatorium Treatment for the Poor.

PMID- 29839076
TI  - The Practice Market: I. Introductory Article.

PMID- 29839075
TI  - Treatment of Fistula in Ano.

PMID- 29839077
TI  - Institutional Notes and News.

PMID- 29839078
TI  - Medical Opinion and Movement.

PMID- 29839079
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29839080
TI  - Parliament and Publications.

PMID- 29839081
TI  - Hospital World.

PMID- 29839082
TI  - Annotations.

PMID- 29839084
TI  - The Week's Work.

PMID- 29839083
TI  - The Hospital for Sick Children, Great Ormond St.

PMID- 29839085
TI  - News and Events of the Week.

PMID- 29839086
TI  - Mr. Shaw Again.

PMID- 29839087
TI  - Ionisation.

PMID- 29839088
TI  - Medical Defence.

PMID- 29839090
TI  - Haematuria and Nephritis of Sudden Onset as an Initial Symptom of Typhoid Fever.

PMID- 29839089
TI  - Infective Arthritis.-I.

PMID- 29839091
TI  - Medical Opinion and Movement.

PMID- 29839092
TI  - The Week's Work.

PMID- 29839094
TI  - A New Type of Motor Ambulance.

PMID- 29839093
TI  - Variation and Environment in Disease.

PMID- 29839096
TI  - The Surgical Uses of Iodine.

PMID- 29839095
TI  - The Hospital World.

PMID- 29839098
TI  - Hospital Architecture and Construction.

PMID- 29839097
TI  - Hospital Architecture.

PMID- 29839099
TI  - The Tropics and Life Assurance.

PMID- 29839100
TI  - Home and Continental Spas: II. Droitwich.

PMID- 29839101
TI  - Jaundice in Secondary Syphilis.

PMID- 29839102
TI  - The Week in the Courts.

PMID- 29839103
TI  - Cutaneous Diphtheria.

PMID- 29839104
TI  - Annotations.

PMID- 29839106
TI  - Gas in the Stomach; Its Causation and Treatment.

PMID- 29839105
TI  - A Probable New Human Trypanosome.

PMID- 29839107
TI  - Institutional Notes and News.

PMID- 29839108
TI  - News and Events of the Week.

PMID- 29839109
TI  - By the Way.

PMID- 29839110
TI  - Parliament and Publications.

PMID- 29839111
TI  - The Operative Treatment of Fractures.

PMID- 29839112
TI  - Hospital Relief in Holland.

PMID- 29839113
TI  - Institutional Notes and News.

PMID- 29839114
TI  - Clothing for the British Climate.

PMID- 29839115
TI  - Parliament and Publications.

PMID- 29839117
TI  - News and Events of the Week.

PMID- 29839116
TI  - Drug Eruptions: Their Nature and Varieties.

PMID- 29839118
TI  - Medical Education in the United States.

PMID- 29839119
TI  - The Week's Work.

PMID- 29839120
TI  - New Appliances and Things Medical.

PMID- 29839121
TI  - Hospital Architecture and Construction.

PMID- 29839122
TI  - Annotations.

PMID- 29839123
TI  - The Hospital World.

PMID- 29839125
TI  - Hospital Administration and Organisation in South Africa.

PMID- 29839124
TI  - Medical Opinion and Movement.

PMID- 29839127
TI  - Money, Mind, and Molars.

PMID- 29839126
TI  - Dioxydiamidoarsenobenzol.

PMID- 29839129
TI  - Parliament and Publications.

PMID- 29839128
TI  - Turin International Exhibition 1911. The British Section.

PMID- 29839131
TI  - An American Cottage Hospital.

PMID- 29839130
TI  - Irish Books and English Reviewers.

PMID- 29839132
TI  - The Week's Work.

PMID- 29839133
TI  - Transillumination of the Nasal Accessory Cavities.

PMID- 29839135
TI  - Infantile Mortality and Amateur Hygienists.

PMID- 29839134
TI  - Medical Opinion and Movement.

PMID- 29839136
TI  - Notes on Hospital Planning.

PMID- 29839137
TI  - Annotations.

PMID- 29839139
TI  - The Week in the Courts.

PMID- 29839138
TI  - Institutional Notes and News.

PMID- 29839140
TI  - Pit Ponies.

PMID- 29839141
TI  - The Hospital World.

PMID- 29839142
TI  - What Is Meant by Insanity.

PMID- 29839143
TI  - News and Events of the Week.

PMID- 29839144
TI  - The Lighting of Hospitals.

PMID- 29839146
TI  - The Lighting of Hospitals.

PMID- 29839145
TI  - New Appliances and Things Medical.

PMID- 29839147
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29839148
TI  - Medical Opinion and Movement.

PMID- 29839150
TI  - News and Events of the Week.

PMID- 29839149
TI  - New Appliances and Things Medical.

PMID- 29839151
TI  - "Bovril" Specialties.

PMID- 29839152
TI  - The Week's Work.

PMID- 29839154
TI  - Institutional Notes and News.

PMID- 29839153
TI  - The Lack of Calcium Salts in the Food of Troops on Active Service as a
      Predisposing Cause of Enteric Fever and Dysentery.

PMID- 29839155
TI  - Research Defence Society.

PMID- 29839156
TI  - Medical Fees.

PMID- 29839158
TI  - Annotations.

PMID- 29839157
TI  - Skin Affections of the Beard Region Due to Micro-Organisms, and Their Treatment.

PMID- 29839159
TI  - An Excellent Example.

PMID- 29839160
TI  - The Hospital World.

PMID- 29839161
TI  - Notes on Hospital Planning.

PMID- 29839163
TI  - The Hospital World.

PMID- 29839162
TI  - The Norfolk and Norwich Hospital.

PMID- 29839164
TI  - Bath.

PMID- 29839165
TI  - Medical Charges.

PMID- 29839166
TI  - News and Events of the Week.

PMID- 29839167
TI  - The Venom of Scorpions.

PMID- 29839168
TI  - The Operative Treatment of Fractures.

PMID- 29839169
TI  - The Reform of Medical Education in France.

PMID- 29839170
TI  - Institutional Notes and News.

PMID- 29839171
TI  - Relating to Out-Patients Only.

PMID- 29839173
TI  - Annotations.

PMID- 29839172
TI  - Aortic Compression.

PMID- 29839175
TI  - The Week's Work.

PMID- 29839174
TI  - The Week in the Courts.

PMID- 29839176
TI  - Medical Portraiture.

PMID- 29839177
TI  - The Treatment of Corneal Ulcers.

PMID- 29839178
TI  - The Reform of Medical Education in France.

PMID- 29839179
TI  - Hospitals and the Law in 1910.

PMID- 29839180
TI  - The Ward Floor: II. Practical Details.

PMID- 29839181
TI  - Medical Opinion and Movement.

PMID- 29839182
TI  - Practical Notes on Surgical Diagnosis and Treatment.

PMID- 29839184
TI  - The Week in the Courts.

PMID- 29839183
TI  - Some Points in the Treatment of Scarlet Fever.

PMID- 29839185
TI  - The New King's College Hospital, Denmark Hill.

PMID- 29839186
TI  - Strangulated Hernia.

PMID- 29839188
TI  - News and Events of the Week.

PMID- 29839187
TI  - Institutional Notes and News.

PMID- 29839189
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29839190
TI  - The Week's Work.

PMID- 29839191
TI  - King's College Hospital.

PMID- 29839192
TI  - The Bubonic Plague and Chinese Remedies.

PMID- 29839193
TI  - Sweating and Anaesthesia.

PMID- 29839194
TI  - Medical Opinion and Movement.

PMID- 29839195
TI  - Annotations.

PMID- 29839196
TI  - The Late King and the Hospitals.

PMID- 29839198
TI  - The Hospital World.

PMID- 29839197
TI  - Royal Portsmouth Hospital.

PMID- 29839199
TI  - Parliament and Publications.

PMID- 29839200
TI  - Doctors and International Peace.

PMID- 29839202
TI  - Some Spinal Cord Lesions: I. Primary Spastic and Ataxic Paraplegia.

PMID- 29839201
TI  - A Controlling Authority for Voluntary Hospitals.

PMID- 29839203
TI  - The General Practitioner-His Book.

PMID- 29839204
TI  - New Appliances and Things Medical.

PMID- 29839206
TI  - Water Supply.

PMID- 29839205
TI  - The Hospital World.

PMID- 29839207
TI  - News and Events of the Week.

PMID- 29839208
TI  - An Unusual Source of Lead Poisoning.

PMID- 29839209
TI  - Infective Arthritis.-II.

PMID- 29839210
TI  - Parliament and Publications.

PMID- 29839211
TI  - Electric Clocks for Hospitals.

PMID- 29839212
TI  - Stage Children.

PMID- 29839213
TI  - Public Hospitals and Their Maintenance.

PMID- 29839215
TI  - Buxton.

PMID- 29839214
TI  - Legacies to Hospitals.

PMID- 29839216
TI  - Surgical and InstitutionalAppliances: Hospital Equipment and Instruments for the
      General Practitioner.

PMID- 29839217
TI  - Primary Sarcoma of the Appendix.

PMID- 29839219
TI  - Regimental Camp Sanitary Reports.

PMID- 29839218
TI  - The Future of the Metropolitan Hospital Sunday Fund.

PMID- 29839220
TI  - Institutional Notes and News.

PMID- 29839221
TI  - The Smallpox Outbreak.

PMID- 29839223
TI  - The Week's Work.

PMID- 29839222
TI  - New Appliances &c.

PMID- 29839224
TI  - The Practice Market: II. Selling a Practice.

PMID- 29839226
TI  - Annotations.

PMID- 29839225
TI  - Some New Remedies in Use.

PMID- 29839227
TI  - The Week in the Courts.

PMID- 29839228
TI  - Medical Opinion and Movement.

PMID- 29839229
TI  - Retreading of Tyres.

PMID- 29839230
TI  - Stage Management at a Hospital.

PMID- 29839231
TI  - Institutional Questions.

PMID- 29839232
TI  - Artificial Serum in Puerperal Septicaemia.

PMID- 29839233
TI  - The Dispensaries of Assam.

PMID- 29839234
TI  - Biliary Colic.

PMID- 29839235
TI  - The Role of the "Liver."

PMID- 29839236
TI  - Street Cleansing.

PMID- 29839237
TI  - New Appliances and Things Medical.

PMID- 29839238
TI  - Progress in Psychiatry.

PMID- 29839239
TI  - The Story of the Insane from Year to Year.

PMID- 29839240
TI  - Heredity in Disease.

PMID- 29839242
TI  - Statistics.

PMID- 29839241
TI  - Hospital Construction.

PMID- 29839244
TI  - Apomorphine.

PMID- 29839243
TI  - Progress in Surgery.

PMID- 29839245
TI  - Annotations.

PMID- 29839246
TI  - Normal Saline in Septic Cases.

PMID- 29839248
TI  - "The Hospital" Nursing Mirror.

PMID- 29839247
TI  - Notes and News.

PMID- 29839249
TI  - Modern Sociology.

PMID- 29839250
TI  - Non-Diabetic Glycosuria.

PMID- 29839251
TI  - The Medical Charities of Manchester.

PMID- 29839252
TI  - Physical Education.

PMID- 29839253
TI  - The Hospital Section at the Woman's Exhibition.

PMID- 29839254
TI  - New Appliances and Things Medical.

PMID- 29839255
TI  - "The Hospital" Nursing Mirror.

PMID- 29839256
TI  - Hospitals and the Limited Liability Act.

PMID- 29839258
TI  - Gunshot Wounds.

PMID- 29839257
TI  - Thirst.

PMID- 29839259
TI  - Ambulant Small-Pox.

PMID- 29839260
TI  - Notes and News.

PMID- 29839261
TI  - Hospital Meetings, &c.

PMID- 29839262
TI  - Dressing a Case.

PMID- 29839264
TI  - Progress in Surgery.

PMID- 29839263
TI  - Annotations.

PMID- 29839265
TI  - Progress in Medicine.

PMID- 29839266
TI  - Legislation for Midwives.

PMID- 29839267
TI  - The Sea and Its Dead.

PMID- 29839268
TI  - Operation in Simple Fractures.

PMID- 29839269
TI  - Progress in Otology.

PMID- 29839270
TI  - Hospital Meetings, &c.

PMID- 29839272
TI  - Infant Symptoms and Modification of Food.

PMID- 29839271
TI  - Urotropine in Typhoid Fever.

PMID- 29839273
TI  - Progress in Psychiatry.

PMID- 29839274
TI  - The Right to Die.

PMID- 29839275
TI  - Notes and News.

PMID- 29839276
TI  - The Treatment of Cirrhosis.

PMID- 29839278
TI  - "The Hospital" Nursing Mirror.

PMID- 29839277
TI  - The Royal London Ophthalmic Hospital (Moorfields).

PMID- 29839279
TI  - Backache.

PMID- 29839280
TI  - The Percentage of Fat in Infants' Food.

PMID- 29839281
TI  - Climate and Clothing.

PMID- 29839282
TI  - The Cancer Wards at the Middlesex Hospital.

PMID- 29839283
TI  - Annotations.

PMID- 29839284
TI  - Progress in Surgery.

PMID- 29839285
TI  - The Roosevelt Hospital.

PMID- 29839286
TI  - "The Hospital" Nursing Mirror.

PMID- 29839287
TI  - Annotations.

PMID- 29839288
TI  - Notes and News.

PMID- 29839289
TI  - Modern Sociology.

PMID- 29839290
TI  - Life of the Late Sir Andrew Clark.

PMID- 29839291
TI  - Holidays.

PMID- 29839292
TI  - The Present-Day Treatment of Syphilis.

PMID- 29839294
TI  - Architects and Modern Hospitals.

PMID- 29839293
TI  - Instinct versus Discipline.

PMID- 29839295
TI  - Experiments upon Animals.

PMID- 29839296
TI  - Progress in Medicine.

PMID- 29839297
TI  - The Over-Feeding of Infants.

PMID- 29839298
TI  - Hospital Meetings, &c.

PMID- 29839299
TI  - New Appliances and Things Medical.

PMID- 29839300
TI  - Schools and Measles.

PMID- 29839301
TI  - Progress in Surgery.

PMID- 29839302
TI  - The Story of the Insane from Year to Year.

PMID- 29839303
TI  - "The Hospital" Nursing Mirror.

PMID- 29839304
TI  - Some Errors about Cancer of the Breast.

PMID- 29839305
TI  - Food Poisoning.

PMID- 29839306
TI  - Progress in Surgery.

PMID- 29839307
TI  - Rest in Rheumatism.

PMID- 29839308
TI  - Hospital Construction.

PMID- 29839309
TI  - Institutional Questions.

PMID- 29839310
TI  - Hospital Meetings, &c.

PMID- 29839311
TI  - Progress in Bacteriology.

PMID- 29839312
TI  - Annotations.

PMID- 29839313
TI  - Therapeutical Notes.

PMID- 29839314
TI  - The Newer Knowledge on Typhoid Fever.

PMID- 29839315
TI  - Faeculent Vomiting Which Is Sometimes Curative.

PMID- 29839316
TI  - Gout.

PMID- 29839317
TI  - New Appliances and Things Medical.

PMID- 29839318
TI  - Notes and News.

PMID- 29839320
TI  - The Treatment of Disease by Baths and Waters.

PMID- 29839319
TI  - Practical Departments.

PMID- 29839321
TI  - Eucaine Anaesthesia.

PMID- 29839322
TI  - Hospital Meetings, &c.

PMID- 29839323
TI  - Glances at the Hospitals.

PMID- 29839324
TI  - Brains and Railway Accidents.

PMID- 29839326
TI  - Quinine and Malaria.

PMID- 29839325
TI  - Practice by Companies.

PMID- 29839327
TI  - Pathology and Treatment of Insanity.

PMID- 29839328
TI  - Erratum.
AB  - [This corrects the article on p. 220a in vol. 28.].

PMID- 29839330
TI  - Annotations.

PMID- 29839329
TI  - Notes and News.

PMID- 29839332
TI  - Progress in Surgery.

PMID- 29839331
TI  - Progress in Medicine.

PMID- 29839333
TI  - New Appliances and Things Medical.

PMID- 29839334
TI  - "The Hospital" Nursing Mirror.

PMID- 29839335
TI  - The Physical Treatment of Insomnia.

PMID- 29839336
TI  - Lead Poisoning among Women.

PMID- 29839338
TI  - Annotations.

PMID- 29839337
TI  - New Appliances and Things Medical.

PMID- 29839339
TI  - Progress in State Medicine.

PMID- 29839340
TI  - On Some Pathological Problems of To-Day.

PMID- 29839341
TI  - Cigarette Smoking.

PMID- 29839342
TI  - Notes and News.

PMID- 29839343
TI  - Hospital Meetings, &c.

PMID- 29839344
TI  - "The Hospital" Nursing Mirror.

PMID- 29839345
TI  - Institutional Questions.

PMID- 29839346
TI  - Progress in Medicine.

PMID- 29839347
TI  - The Artificial Feeding of Infants.

PMID- 29839348
TI  - Puerperal Fever.

PMID- 29839350
TI  - Drink and Heredity.

PMID- 29839349
TI  - The Unconventional Inspector.

PMID- 29839352
TI  - Progress in Gynaecology.

PMID- 29839351
TI  - Hospitals and Rates.

PMID- 29839353
TI  - Hospital Meetings, &c.

PMID- 29839354
TI  - Massage in Recent Fractures.

PMID- 29839355
TI  - Progress in Medicine.

PMID- 29839356
TI  - Sutures after Abdominal Incisions.

PMID- 29839357
TI  - New Appliances and Things Medical.

PMID- 29839359
TI  - Annotations.

PMID- 29839358
TI  - The Various Forms of Meningitis.

PMID- 29839360
TI  - Progress in Psychiatry.

PMID- 29839361
TI  - The Physics of Steam Sterilisation.

PMID- 29839363
TI  - Epidemic Measles.

PMID- 29839362
TI  - Displacement of the Dilated Stomach.

PMID- 29839364
TI  - Eternal Vigilance.

PMID- 29839365
TI  - "The Hospital" Nursing Mirror.

PMID- 29839366
TI  - The Incubation of Plague.

PMID- 29839367
TI  - Therapeutical Notes.

PMID- 29839369
TI  - Progress in Otology.

PMID- 29839368
TI  - Medical Fees from Hospital Patients.

PMID- 29839371
TI  - The Princess Christian Hospital Train.

PMID- 29839370
TI  - Notes and News.

PMID- 29839373
TI  - Tannate of Mercury.

PMID- 29839372
TI  - "The Hospital" Nursing Mirror.

PMID- 29839374
TI  - Legislation for Midwives.

PMID- 29839375
TI  - The Proctologist.

PMID- 29839377
TI  - Notes and News.

PMID- 29839376
TI  - Progress in Surgery.

PMID- 29839378
TI  - The Lime-Juice Ration.

PMID- 29839379
TI  - Mafeking.

PMID- 29839380
TI  - Annotations.

PMID- 29839381
TI  - Diet in Diabetes.

PMID- 29839383
TI  - Progress in Gynaecology.

PMID- 29839382
TI  - The X Ray in the Law Courts.

PMID- 29839384
TI  - New Appliances and Things Medical.

PMID- 29839385
TI  - Gout, Rheumatism, and Rheumatoid Arthritis.

PMID- 29839386
TI  - Progress in Medicine.

PMID- 29839387
TI  - Hospital Meetings, &c.

PMID- 29839388
TI  - The Story of the Insane from Year to Year.

PMID- 29839389
TI  - The Treatment of Septic Peritonitis.

PMID- 29839390
TI  - Our "Consulting Surgeons."

PMID- 29839391
TI  - Hospital Meetings, &c.

PMID- 29839393
TI  - Institutional Questions.

PMID- 29839392
TI  - The Gynaecological Society.

PMID- 29839394
TI  - The Lunatic Asylums of India.

PMID- 29839395
TI  - Progress in Medicine.

PMID- 29839397
TI  - Progress in Surgery.

PMID- 29839396
TI  - Annotations.

PMID- 29839398
TI  - Bacteria and Sewage.

PMID- 29839399
TI  - "The Hospital" Nursing Mirror.

PMID- 29839400
TI  - Doubtful Tumours of the Breast.

PMID- 29839401
TI  - A Mining Accident.

PMID- 29839402
TI  - New Appliances and Things Medical.

PMID- 29839403
TI  - The Negro.

PMID- 29839404
TI  - Sponge Counting.

PMID- 29839405
TI  - Modern Sociology.

PMID- 29839406
TI  - The Modern Treatment of Uterine Fibroids.

PMID- 29839407
TI  - Glances at the Hospitals.

PMID- 29839408
TI  - Isolation within Isolation Hospitals.

PMID- 29839409
TI  - Progress in Otology.

PMID- 29839410
TI  - Notes and News.

PMID- 29839411
TI  - The Story of the Insane from Year to Year.

PMID- 29839413
TI  - New Appliances and Things Medical.

PMID- 29839412
TI  - Therapeutical Notes.

PMID- 29839414
TI  - Progress in Medicine.

PMID- 29839415
TI  - "The Hospital" Nursing Mirror.

PMID- 29839416
TI  - The Red Cross.

PMID- 29839417
TI  - Notes and News.

PMID- 29839419
TI  - Sir T. Lauder Brunton on Indigestion.

PMID- 29839418
TI  - Post-Mortem Examinations in Asylums.

PMID- 29839420
TI  - Women and Warfare.

PMID- 29839421
TI  - The Verulam Review and the British Medical Association.

PMID- 29839422
TI  - Progress in Gynaecology.

PMID- 29839423
TI  - The Treatment of Lupus by X-Rays.

PMID- 29839425
TI  - Hospital Meetings, &c.

PMID- 29839424
TI  - Modern Sociology.

PMID- 29839426
TI  - A Consultation at the Polyclinic.

PMID- 29839427
TI  - Progress in Surgery.

PMID- 29839428
TI  - Annotations.

PMID- 29839429
TI  - The Yeomanry Hospital.

PMID- 29839430
TI  - Progress in Surgery.

PMID- 29839431
TI  - Medical Ethics in the Sixteenth Century.

PMID- 29839432
TI  - The Cause of Diabetes.

PMID- 29839433
TI  - "The Hospital" Nursing Mirror.

PMID- 29839434
TI  - Progress in Anaesthetics.

PMID- 29839435
TI  - The National Hospital.

PMID- 29839436
TI  - Progress in Dermatology.

PMID- 29839437
TI  - Annotations.

PMID- 29839439
TI  - New Appliances and Things Medical.

PMID- 29839438
TI  - Notes and News.

PMID- 29839440
TI  - The Treatment of Lupus by Concentrated Light.

PMID- 29839441
TI  - Gout and Hay-Fever.

PMID- 29839442
TI  - Enteric Fever among Soldiers.

PMID- 29839443
TI  - Legislation for Midwives.

PMID- 29839445
TI  - Institutional Questions.

PMID- 29839444
TI  - Food Preservatives.

PMID- 29839447
TI  - Medical Inspection of Schools.

PMID- 29839446
TI  - Light and Vision.

PMID- 29839449
TI  - Mosquitos Again.

PMID- 29839448
TI  - The Imperial Yeomanry Hospital.

PMID- 29839450
TI  - The Chemists' Exhibition, 1900.

PMID- 29839451
TI  - Notes and News.

PMID- 29839452
TI  - Old Men's Children.

PMID- 29839453
TI  - Hospital Meetings, &c.

PMID- 29839454
TI  - Glances at the Hospitals.

PMID- 29839455
TI  - Mind Your Own Business.

PMID- 29839456
TI  - Progress in Surgery.

PMID- 29839457
TI  - Editor's Letter-Box.

PMID- 29839458
TI  - The Blood-Stained Pillow.

PMID- 29839459
TI  - Annotations.

PMID- 29839461
TI  - Institutional Questions.

PMID- 29839460
TI  - Clinical Lecture on Eclampsia.

PMID- 29839462
TI  - "The Hospital" Nursing Mirror.

PMID- 29839463
TI  - The Prince of Wales's Hospital Fund.

PMID- 29839465
TI  - Two Old-Fashioned Remedies in Gout.

PMID- 29839464
TI  - Anti-Typhoid Inoculation.

PMID- 29839466
TI  - How to Give Digitalis.

PMID- 29839467
TI  - Professional Prospects.

PMID- 29839468
TI  - The Medical Schools.

PMID- 29839469
TI  - Annotations.

PMID- 29839470
TI  - Notes and News.

PMID- 29839471
TI  - Medical Qualifications.

PMID- 29839472
TI  - Progress in Medicine.

PMID- 29839473
TI  - "The Hospital" Nursing Mirror.

PMID- 29839474
TI  - Progress in Surgery.

PMID- 29839475
TI  - A Word to Would-Be Students on the Course of Study.

PMID- 29839476
TI  - The Medical Profession in the United States.

PMID- 29839477
TI  - Progress in Psychiatry.

PMID- 29839479
TI  - Rupture of the Liver.

PMID- 29839478
TI  - The Errors of Radiography.

PMID- 29839480
TI  - Progress in Surgery.

PMID- 29839481
TI  - "The Hospital" Nursing Mirror.

PMID- 29839482
TI  - Institutional Questions.

PMID- 29839483
TI  - Modern Sociology.

PMID- 29839484
TI  - Progress in Medicine.

PMID- 29839485
TI  - Notes and News.

PMID- 29839487
TI  - Anderson v. Moeller.

PMID- 29839486
TI  - The Aix Douche-Massage.

PMID- 29839489
TI  - Annotations.

PMID- 29839488
TI  - The "Plague of Women".

PMID- 29839490
TI  - Antiseptics in Minor Surgery.

PMID- 29839491
TI  - Therapeutical Notes.

PMID- 29839492
TI  - Post-Mortem Examinations in Asylums.

PMID- 29839493
TI  - Glances at the Hospitals.

PMID- 29839494
TI  - Lessons from the War.

PMID- 29839495
TI  - The Story of the Insane from Year to Year.

PMID- 29839496
TI  - The Malaria Parasite.

PMID- 29839497
TI  - A Mosquito-Proof Dwelling-House.

PMID- 29839498
TI  - Legislation for Midwives.

PMID- 29839500
TI  - The Enforcement of Sanitary Law.

PMID- 29839499
TI  - New Appliances and Things Medical.

PMID- 29839502
TI  - Diabetes from Nerve Strain.

PMID- 29839501
TI  - Hospital Meetings, &c.

PMID- 29839503
TI  - Therapeutical Notes.

PMID- 29839504
TI  - Notification and Isolation.

PMID- 29839506
TI  - Advertising Dentists.

PMID- 29839505
TI  - Lunacy Scandals.

PMID- 29839508
TI  - The Treatment of Cancer by Arsenic.

PMID- 29839507
TI  - Muscular Rigidity in Acute Peritonitis.

PMID- 29839510
TI  - Stricture of the Urethra.

PMID- 29839509
TI  - Hospital Meetings, &c.

PMID- 29839512
TI  - Progress in Psychiatry.

PMID- 29839511
TI  - Modern Sociology.

PMID- 29839513
TI  - Marriage of First Cousins.

PMID- 29839514
TI  - Asylum Expenditure.

PMID- 29839515
TI  - Appendicitis.

PMID- 29839516
TI  - Gangrene of the Penis.

PMID- 29839517
TI  - Progress in Otology.

PMID- 29839518
TI  - Progress in Medicine.

PMID- 29839520
TI  - Glances at the Hospitals.

PMID- 29839519
TI  - Annotations.

PMID- 29839521
TI  - The Medical, Surgical, and Hygienic Exhibition, 1900.

PMID- 29839522
TI  - "The Hospital" Nursing Mirror.

PMID- 29839523
TI  - Legislation for Midwives.-A Reply.

PMID- 29839524
TI  - Notes and News.

PMID- 29839525
TI  - Hospital Meetings, &c.

PMID- 29839526
TI  - Progress in Bacteriology.

PMID- 29839528
TI  - Notes and News.

PMID- 29839527
TI  - "The Hospital" Nursing Mirror.

PMID- 29839529
TI  - Circumcision.

PMID- 29839530
TI  - Annotations.

PMID- 29839531
TI  - Procedures Relative to the Single Care of Insane Persons.

PMID- 29839532
TI  - Progress in Ophthalmology.

PMID- 29839533
TI  - Institutional Questions.

PMID- 29839534
TI  - The Hospitals Inquiry.

PMID- 29839535
TI  - New Appliances and Things Medical.

PMID- 29839536
TI  - Industrial Lead Poisoning.

PMID- 29839537
TI  - How to Measure for a Truss.

PMID- 29839538
TI  - Porro's Operation and Caesarian Section.

PMID- 29839539
TI  - Hospital Construction.

PMID- 29839540
TI  - Progress in Surgery.

PMID- 29839541
TI  - Glances at the Hospitals.

PMID- 29839542
TI  - The Ipswich Meeting of the British Medical Association.

PMID- 29839543
TI  - Progress in Surgery.

PMID- 29839544
TI  - Ptomaine Poisoning.

PMID- 29839545
TI  - Progress in Psychiatry.

PMID- 29839546
TI  - Notes and News.

PMID- 29839547
TI  - The League of Mercy.

PMID- 29839548
TI  - The Royal Military Benevolent Fund.

PMID- 29839549
TI  - New Appliances and Things Medical.

PMID- 29839550
TI  - On the Prevention of Insanity.

PMID- 29839552
TI  - Glances at the Hospitals.

PMID- 29839551
TI  - The President's Address.

PMID- 29839553
TI  - The Address in Surgery.

PMID- 29839554
TI  - Institutional Questions.

PMID- 29839555
TI  - Annotations.

PMID- 29839556
TI  - Progress in Medicine.

PMID- 29839557
TI  - "The Hospital" Nursing Mirror.

PMID- 29839558
TI  - The Butchers and Tuberculous Meat.

PMID- 29839559
TI  - Army Doctors in the Future.

PMID- 29839560
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29839561
TI  - Glances at the Hospitals.

PMID- 29839562
TI  - Progress in Medicine.

PMID- 29839563
TI  - Women as Organisers.

PMID- 29839565
TI  - The Study of Inebriety.

PMID- 29839564
TI  - "The Hospital" Nursing Mirror.

PMID- 29839566
TI  - The Use of a Rubber Dam in Abdominal Operations.

PMID- 29839567
TI  - Modern Sociology.

PMID- 29839569
TI  - Progress in Psychiatry.

PMID- 29839568
TI  - Notes and News.

PMID- 29839570
TI  - Progress in Surgery.

PMID- 29839571
TI  - Scurvy among the Troops.

PMID- 29839572
TI  - The Treatment of Perforation in Typhoid Fever.

PMID- 29839573
TI  - Open-Air "Cures" and Open-Air Work.

PMID- 29839575
TI  - The Hot Air Treatment.

PMID- 29839574
TI  - The British Medical Association and the O'Hara Case.

PMID- 29839577
TI  - Annotations.

PMID- 29839576
TI  - Hospital Construction.

PMID- 29839578
TI  - Preliminary Rashes in Measles.

PMID- 29839579
TI  - The Automobile in Country Practice.

PMID- 29839580
TI  - Ruts and Routine.

PMID- 29839582
TI  - Swindling in Life Assurance.

PMID- 29839581
TI  - Annotations.

PMID- 29839583
TI  - Progress in Dermatology.

PMID- 29839584
TI  - Procedures Relative to the Single Care of Insane Persons.

PMID- 29839585
TI  - New Appliances and Things Medical.

PMID- 29839587
TI  - Fracture by Torsion.

PMID- 29839586
TI  - Progress in Surgery.

PMID- 29839588
TI  - Notes and News.

PMID- 29839589
TI  - Hospital Construction.

PMID- 29839590
TI  - Anti-Typhoid Inoculation.

PMID- 29839591
TI  - Hospital Meetings, &c.

PMID- 29839593
TI  - "The Hospital" Nursing Mirror.

PMID- 29839592
TI  - The Mortality of Abdominal Section.

PMID- 29839594
TI  - Progress in Medicine.

PMID- 29839595
TI  - The So-Called Lunacy "Scandals".

PMID- 29839596
TI  - Who Is to Standardise Drugs?

PMID- 29839597
TI  - Burdett's Hospitals and Charities.

PMID- 29839599
TI  - Hospital Construction.

PMID- 29839598
TI  - Lead Poisoning and Insanity.

PMID- 29839600
TI  - The Civil Dispensaries of the Police Hospitals of Burma.

PMID- 29839601
TI  - Speed in Operations.

PMID- 29839603
TI  - The Future of the Army Medical Service.

PMID- 29839602
TI  - The Treatment of Fractures by Movement and Massage.

PMID- 29839604
TI  - The National Hospital for the Paralysed and Epileptic.

PMID- 29839605
TI  - Annotations.

PMID- 29839606
TI  - Notes and News.

PMID- 29839607
TI  - Holidays.

PMID- 29839608
TI  - The Provision of Pure Drinking Water for Troops on the March.

PMID- 29839609
TI  - Progress in Surgery.

PMID- 29839610
TI  - Progress in Medicine.

PMID- 29839611
TI  - "The Hospital" Nursing Mirror.

PMID- 29839612
TI  - New Appliances and Things Medical.

PMID- 29839613
TI  - Modern Sociology.

PMID- 29839615
TI  - Glances at the Hospitals.

PMID- 29839614
TI  - Hot-Air Treatment.

PMID- 29839617
TI  - Notes and News.

PMID- 29839616
TI  - The Prevention of the Humped Back of Spinal Disease.

PMID- 29839619
TI  - The Medical Institutions of the Presidency Town of Madras.

PMID- 29839618
TI  - Annotations.

PMID- 29839621
TI  - "The Hospital" Nursing Mirror.

PMID- 29839620
TI  - Painless Labour.

PMID- 29839622
TI  - New Appliances and Things Medical.

PMID- 29839623
TI  - Vagrants.

PMID- 29839624
TI  - Notification of Puerperal Fever.

PMID- 29839625
TI  - The Metropolitan Asylums Board of London and Its Work.-1.

PMID- 29839626
TI  - The Story of the Insane from Year to Year.

PMID- 29839627
TI  - Railway Carriages and Infection.

PMID- 29839628
TI  - Progress in Surgery.

PMID- 29839629
TI  - Glances at the Hospitals.

PMID- 29839630
TI  - Notes on the Imperial Yeomanry Base Hospital at Deelfontein.

PMID- 29839631
TI  - Forcible Straightening of Carious Spines.

PMID- 29839632
TI  - Tuberculous Joint Lesions.

PMID- 29839633
TI  - Progress in Laryngology.

PMID- 29839634
TI  - Operation in Appendicitis.

PMID- 29839635
TI  - The British Association and "Malaria".

PMID- 29839636
TI  - Progress in Laryngology.

PMID- 29839637
TI  - Modern Sociology.

PMID- 29839638
TI  - Ambulance Arrangements.

PMID- 29839639
TI  - Some Exploded Theories about Bullet Wounds.

PMID- 29839640
TI  - Notes and News.

PMID- 29839641
TI  - Annotations.

PMID- 29839642
TI  - Field Dressings.

PMID- 29839643
TI  - The Story of the Insane from Year to Year.

PMID- 29839645
TI  - The Expectancy of Life in Cases of Cancer of the Breast.

PMID- 29839644
TI  - Hospital Meetings, &c.

PMID- 29839646
TI  - Progress in Surgery.

PMID- 29839647
TI  - Hospital Construction.

PMID- 29839649
TI  - New Appliances and Things Medical.

PMID- 29839648
TI  - Glances at the Hospitals.

PMID- 29839650
TI  - The Concurrence of Typhoid and Malarial Fever.

PMID- 29839651
TI  - "The Hospital" Nursing Mirror.

PMID- 29839652
TI  - The Isolation Hospital, Southampton.

PMID- 29839653
TI  - The London Water Supply.

PMID- 29839654
TI  - Modern Sociology.

PMID- 29839655
TI  - Notes and News.

PMID- 29839656
TI  - Progress in Psychiatry.

PMID- 29839657
TI  - Glances at the Hospitals.

PMID- 29839659
TI  - The National Hospital for the Paralysed and Epileptic.

PMID- 29839658
TI  - Progress in Gynaecology.

PMID- 29839660
TI  - Hospital Meetings, &c.

PMID- 29839661
TI  - Ambulance Tongas from India for South Africa.

PMID- 29839662
TI  - New Appliances and Things Medical.

PMID- 29839663
TI  - Boer and British Sanitation.

PMID- 29839665
TI  - The International Medical Congress.

PMID- 29839664
TI  - Death by Starvation.

PMID- 29839667
TI  - Political Assassination.

PMID- 29839666
TI  - Annotations.

PMID- 29839669
TI  - Progress in Medicine.

PMID- 29839668
TI  - "The Hospital" Nursing Mirror.

PMID- 29839670
TI  - Rupture of the OEsophagus.

PMID- 29839671
TI  - Procedures Relative to the Single Care of Insane Persons.

PMID- 29839673
TI  - Progress in Surgery.

PMID- 29839672
TI  - A Mouldy Stomach.

PMID- 29839674
TI  - Annotations.

PMID- 29839675
TI  - Sexual Function and Insanity.

PMID- 29839677
TI  - Glances at the Hospitals.

PMID- 29839676
TI  - The Treatment of Acne.

PMID- 29839678
TI  - An Indirect Sewage Nuisance.

PMID- 29839679
TI  - The General Election.

PMID- 29839680
TI  - The Institutional Treatment of Disease.

PMID- 29839681
TI  - Progress in State Medicine.

PMID- 29839682
TI  - Modern Sociology.

PMID- 29839683
TI  - Anti-Typhoid Inoculation.

PMID- 29839684
TI  - "The Hospital" Nursing Mirror.

PMID- 29839685
TI  - Poisoning by Paraldehyde.

PMID- 29839687
TI  - The "Colony Treatment" of Epileptics.

PMID- 29839686
TI  - Progress in Laryngology.

PMID- 29839688
TI  - Institutional Questions.

PMID- 29839689
TI  - The Story of the Insane from Year to Year.

PMID- 29839690
TI  - Notes and News.

PMID- 29839691
TI  - Therapeutical Notes.

PMID- 29839692
TI  - Annotations.

PMID- 29839693
TI  - Progress in Medicine.

PMID- 29839694
TI  - Seccotine in Surgery.

PMID- 29839695
TI  - Progress in Otology.

PMID- 29839696
TI  - Progress in Surgery.

PMID- 29839697
TI  - Editor's Letter-Box.

PMID- 29839698
TI  - Notes and News.

PMID- 29839699
TI  - Fracture of the Patella and of the Olecranon.

PMID- 29839700
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29839701
TI  - The Abuse of Exercise.

PMID- 29839702
TI  - The Imperial Yeomanry Hospital.

PMID- 29839704
TI  - The Static Method in X Ray Work.

PMID- 29839703
TI  - Hypertrophic Pyloric Stenosis in Infancy.

PMID- 29839706
TI  - The Medical, Surgical, and Hygienic Exhibition, 1900.

PMID- 29839705
TI  - New Appliances and Things Medical.

PMID- 29839707
TI  - Expanding Mauser Bullets.

PMID- 29839708
TI  - The Ice-Bag in the Treatment of Pneumonia.

PMID- 29839710
TI  - Special Hospital Sunday Supplement.

PMID- 29839709
TI  - "The Hospital" Nursing Mirror.

PMID- 29839712
TI  - Arsenical Phosphate of Soda.

PMID- 29839711
TI  - Hospital Meetings, &c.

PMID- 29839714
TI  - The Effects of Drugging in Life and in Literature.

PMID- 29839713
TI  - The Interim Report of the Fabian Society.

PMID- 29839716
TI  - Overfeeding and Hygienic Management.

PMID- 29839715
TI  - The Status of Institutional Dispensers.

PMID- 29839717
TI  - Vegetable Soups in the Treatment of Children's Anaemias.

PMID- 29839718
TI  - Fellow-Workers and Their Doings.

PMID- 29839720
TI  - Varied Experiences in a Surgical Ward.

PMID- 29839719
TI  - The Origin and Evolution of the 18th Century Hospital Movement.

PMID- 29839721
TI  - The Skin.

PMID- 29839722
TI  - A Workable System of Cottage Hospital Book-Keeping.

PMID- 29839723
TI  - The National Medical Union (Official): Resolutions on Policy. The Profession of
      Medicine.

PMID- 29839724
TI  - Women Doctors and the Ban on Marriage.

PMID- 29839725
TI  - Wild Life in a Hospital Barrack-Square.

PMID- 29839726
TI  - The Results of Flight upon Normal Health.

PMID- 29839727
TI  - Research and Remedies.

PMID- 29839728
TI  - Hospital and Institutional News.

PMID- 29839729
TI  - Westminster Hospital and Clapham Common.

PMID- 29839730
TI  - Buildings Contemplated and in Progress.

PMID- 29839731
TI  - A Simple Means of Making Carbon Dioxide Snow.

PMID- 29839732
TI  - The Editor's Letter-Box.

PMID- 29839734
TI  - The Value and Risks of Water Exercise.

PMID- 29839733
TI  - Salaries of Poor-Law Medical Officers.

PMID- 29839735
TI  - The Marriage Law and Mental Disease.

PMID- 29839737
TI  - For Hospital Workers.

PMID- 29839736
TI  - Hospital and Institutional News.

PMID- 29839739
TI  - Doctors' Wills.

PMID- 29839738
TI  - The National Medical Union (Official): Resolutions on Policy.

PMID- 29839740
TI  - The Simplification of Colour-Matching.

PMID- 29839741
TI  - The Solvency of Approved Societies.

PMID- 29839742
TI  - Sanatoria Patients and Dental Benefit.

PMID- 29839744
TI  - The River Ambulance Service.

PMID- 29839743
TI  - Research and Remedies.

PMID- 29839745
TI  - The Truth about the Milne Treatment.

PMID- 29839746
TI  - The Interim Report of the Fabian Society.

PMID- 29839747
TI  - Reports on Hospitals of the United Kingdom: Benenden Sanatorium, Kent.

PMID- 29839748
TI  - A Convenient Method of Moving Patients.

PMID- 29839749
TI  - A Criticism of the New Nomenclature.

PMID- 29839750
TI  - Age Limits for Institutional Posts.

PMID- 29839751
TI  - Personalia.

PMID- 29839752
TI  - The Salaries of Poor-Law Medical Officers.

PMID- 29839753
TI  - Fellow-Workers and Their Doings.

PMID- 29839754
TI  - The Central Point of the Chaplain's Work.

PMID- 29839755
TI  - Non-Panel Men and the Medical Directory.

PMID- 29839756
TI  - Sanatoria Buildings at L88 per Bed.

PMID- 29839757
TI  - Hospital and Institutional News.

PMID- 29839758
TI  - A Rare Problem of School Work.

PMID- 29839759
TI  - Fellow-Workers and Their Doings.

PMID- 29839760
TI  - The Modern Medical Bureaucrat.

PMID- 29839761
TI  - Insuring Babies' Lives.

PMID- 29839762
TI  - Reports on Hospitals of the United Kingdom: General Kent and Centerbury Hospital.

PMID- 29839763
TI  - Buildings Contemplated.

PMID- 29839764
TI  - The Patients' Column.

PMID- 29839765
TI  - The National Medical Union (Official): Report of Council Meeting. The Medical
      Benefit "Surplus Funds".

PMID- 29839767
TI  - An Alternative to Institutional Segregation.

PMID- 29839766
TI  - The Treatment of Puerperal Sepsis in General Practice.

PMID- 29839768
TI  - Doctors' Wills.

PMID- 29839769
TI  - The Debate on the Marriage Question.

PMID- 29839771
TI  - Lightning Conductors and Their Tests.

PMID- 29839770
TI  - A Mental Hospital Sketch.

PMID- 29839772
TI  - Personalia.

PMID- 29839773
TI  - Married Women Doctors and Their Appointments.

PMID- 29839774
TI  - The Artificial Pneumothorax Association and Journal.

PMID- 29839776
TI  - Women Doctors and the London County Council.

PMID- 29839775
TI  - Radium in the Treatment of Deafness.

PMID- 29839777
TI  - Provincial Hospital Arrangements: Barnsley-Bath-Barnstaple-A Southern Territorial
      Hospital-Bristol-Cambridge-Essex-Hospital Co-Operation in Exeter-Gravesend
      Guildford-Ipswich-Lancashire-Leicester-Lincolnshire-Middlesbrough-Oldham
      Portsmouth-Hartshill, Staffordshire-Stalybridge-Torquay-Tunbridge Wells-Wakefield
      Walsall (Staffs)-Yarmouth.

PMID- 29839778
TI  - The Problem before the London Hospitals.

PMID- 29839779
TI  - The London Hospital's Arrangements: Guy's Hospital-Metropolitan Hospital-St.
      George's Hospital-St. Mary's Hospital-Westminster Hospital-University College
      Hospital.

PMID- 29839781
TI  - The Hospital Necessities of the Civil Population.

PMID- 29839780
TI  - Some Dangers and Mistakes to Be Avoided.

PMID- 29839782
TI  - Territorial Hospitals and Nursing Service.

PMID- 29839783
TI  - Some Non-Combatant Responsibilities.

PMID- 29839785
TI  - Grateful Thanks to Our War Correspondents.

PMID- 29839784
TI  - Hospital and Institutional News.

PMID- 29839786
TI  - Position of the Voluntary Hospitals.

PMID- 29839787
TI  - The Charity Organisation Society and the Treatment of Tuberculosis in London.

PMID- 29839789
TI  - Maternity and Mothering: The Influence of the Insurance Act upon the Practice of
      Midwifery.

PMID- 29839788
TI  - From the Nurses' Point of View: A Reply to the Criticisms of a Patient.

PMID- 29839790
TI  - Buildings Contemplated.

PMID- 29839791
TI  - Enteritis at Southwark Infirmary.

PMID- 29839793
TI  - Hospital Statistics. I.-Methods of Keeping the Records of Patients.

PMID- 29839792
TI  - Bath Workhouse Infirmary.

PMID- 29839795
TI  - The Nurses' Home at the Massachusetts General Hospital.

PMID- 29839794
TI  - Medical Defence.

PMID- 29839796
TI  - Toxaemia in the Acute Specific Fevers.

PMID- 29839797
TI  - Institutional Organisation in America: II. A Lesson from the Massachusetts
      General Hospital, Boston.

PMID- 29839798
TI  - Reports on Hospitals of the United Kingdom: Caterham Cottage Hospital. The Epsom
      and Ewell Cottage Hospital (Second Notice).

PMID- 29839800
TI  - China Medical Missionary Association.

PMID- 29839799
TI  - Children's Country Holidays Fund.

PMID- 29839802
TI  - The Shortage in the Naval Medical Service.

PMID- 29839801
TI  - The Theory of Fowler's Posture.

PMID- 29839803
TI  - Over-Insurance.

PMID- 29839804
TI  - A Hospital Equerry for the King.

PMID- 29839805
TI  - Fellow-Workers and Their Doings.

PMID- 29839806
TI  - The Relation of the School Doctor to the Private Practitioner.

PMID- 29839807
TI  - Hospital and Institutional News.

PMID- 29839808
TI  - Some Historic Children's Hospital Cots.

PMID- 29839809
TI  - The Tuberculosis Society.

PMID- 29839810
TI  - Personalia.

PMID- 29839811
TI  - New Developments at "The London": How the Growth of Work Is Being Met.

PMID- 29839813
TI  - Fellow-Workers and Their Doings.

PMID- 29839812
TI  - Medical Hydrology.

PMID- 29839814
TI  - A List of Non-Panel Men.

PMID- 29839815
TI  - Prevention of Sickness under the Act.

PMID- 29839817
TI  - The Poor-Law Medical Officers' Association.

PMID- 29839816
TI  - The Editor's Letter-Box.

PMID- 29839818
TI  - The Retrograde Policy of the Bath Guardians.

PMID- 29839819
TI  - The Orthopaedic Department: VIII. The Plaster Room (continued). Modern Methods in
      Celluloid Work.

PMID- 29839820
TI  - Hospital and Institutional News.

PMID- 29839822
TI  - The Treatment of Frontal Sinus Suppuration.

PMID- 29839821
TI  - A Simple Treatment for Post-Partum Haemorrhage.

PMID- 29839823
TI  - The Nursing and Care of the Sick Prior to 1850.

PMID- 29839825
TI  - Poor-Law Medical Officers and Post-Mortems.

PMID- 29839824
TI  - The National Medical Union (Official): Report of Provisional Federating Council.
      National Medical Union Dinner.

PMID- 29839827
TI  - Hospitals and the Dust Nuisance.

PMID- 29839826
TI  - Economy in the Generation and Use of Steam: III. Prevention of Waste.

PMID- 29839829
TI  - Buildings Contemplated.

PMID- 29839828
TI  - The Department of Modern Nursing: St. Mary's Hospital.

PMID- 29839830
TI  - Personalia.

PMID- 29839831
TI  - Working Men and Representation: Mr. Roden Orde on the Principle and Its
      Application.

PMID- 29839833
TI  - Johns Hopkins Hospital.

PMID- 29839832
TI  - Collargol Pyelography: A Warning.

PMID- 29839834
TI  - Hospital and Institutional News.

PMID- 29839835
TI  - The Treatment of Ankylostoma Anaemia.

PMID- 29839837
TI  - Certain Provincial Hospitals: Their Dissolution or Reform.

PMID- 29839836
TI  - Disablement Benefit-The Last of the Benefits to Come into Operation.

PMID- 29839839
TI  - Panel Practitioners and Chemists.

PMID- 29839838
TI  - The Problem of Functional Paralysis.

PMID- 29839841
TI  - Fellow-Workers and Their Doings.

PMID- 29839840
TI  - British Pharmaceutical Conference.

PMID- 29839843
TI  - The Ambulance Attendant: A Curious Case.

PMID- 29839842
TI  - The History of Charing Cross Hospital and School.

PMID- 29839844
TI  - The Progress of Mental Treatment in Scotland: Boarding-Out or Institutional
      Treatment?

PMID- 29839845
TI  - The Royal National Sanatorium.

PMID- 29839846
TI  - The Repetition of Prescriptions.

PMID- 29839847
TI  - The Examination of Proposers for Life Insurance.

PMID- 29839848
TI  - Reports on Hospitals of the United Kingdom: The Royal Southern Hospital,
      Liverpool. The Holmesdale Cottage Hospital, Sevenoaks.

PMID- 29839850
TI  - The Administration of the Willesden Workhouse.

PMID- 29839849
TI  - The Metropolitan Hospital.

PMID- 29839851
TI  - New Developments at Leicester.

PMID- 29839852
TI  - The Causation of Apoplexy.

PMID- 29839854
TI  - New Infirmary Scheme at Bristol: The Reorganisation of the Indoor Medical Work.

PMID- 29839853
TI  - The Secretaryship of St. Mark's.

PMID- 29839856
TI  - Americans on the Voluntary System: The Criticisms of Visiting Surgeons.

PMID- 29839855
TI  - The Clinical Congress.

PMID- 29839857
TI  - The Department of Modern Nursing: North London or University College Hospital.

PMID- 29839858
TI  - The Distribution Committee.

PMID- 29839859
TI  - Report of the Committee of Distribution to the Council.

PMID- 29839860
TI  - War and Insanity.

PMID- 29839861
TI  - The Administrative Problem of Workhouse Nursing.

PMID- 29839862
TI  - The Second Annual Report.

PMID- 29839863
TI  - Fellow-Workers and Their Doings.

PMID- 29839864
TI  - Medical Services and Hospitals of the Crown: A Survey of Our Organisation.

PMID- 29839865
TI  - Reply to the Criticisms of a Patient.

PMID- 29839866
TI  - Hospital and Institutional News.

PMID- 29839867
TI  - The Electrical and Radio-Therapeutic Department of the Cancer Hospital (Free),
      London: Details of Equipment and Cost.

PMID- 29839869
TI  - Description of the Buildings.

PMID- 29839868
TI  - Hospital Saturday, the Truck Act and Workmen's Contributions.

PMID- 29839870
TI  - Some Details of the Scheme.

PMID- 29839871
TI  - Aerial Conveyance of Infectious Diseases: A Hint for Fever Hospital
      Administrators.

PMID- 29839872
TI  - The National Medical Union Dinner.

PMID- 29839874
TI  - Pensions for Hospital Employees: The Discussion on Mr. Michelli's Paper.

PMID- 29839873
TI  - Voluntary Hospitals in Relation to Social Service Work: The Discussion on
      Councillor Shaw's Paper.

PMID- 29839875
TI  - A Ministry of Public Health.

PMID- 29839877
TI  - The Colour Problem in Hospital Life: Coloured Students: Factors in the
      Controversy.

PMID- 29839876
TI  - Proposed Amendment of the Truck Acts, 1831 to 1896, and How It May Affect the
      Voluntary Hospitals: The Discussion on Mr. Straker's Paper. The Business Meeting.
      The Next Conference.

PMID- 29839878
TI  - Hospital and Institutional News.

PMID- 29839879
TI  - The Bath Workhouse Infirmary.

PMID- 29839880
TI  - Ground Floor Plan.

PMID- 29839881
TI  - Institutional Defalcations.

PMID- 29839882
TI  - The Doctors' Wives Association.

PMID- 29839883
TI  - Architects' Description of the Buildings.

PMID- 29839884
TI  - Reports on Hospitals of the United Kingdom: Three Leicester Hospitals: (1) The
      Faire Hospital-(2) The Maternity Hospital-(3) The Highfield Hospital.

PMID- 29839886
TI  - Opening of a Large New Wing.

PMID- 29839885
TI  - The New Insurance Books.

PMID- 29839887
TI  - The Electrical and Radio-Therapeutic Department of the Cancer Hospital (Free),
      London.

PMID- 29839888
TI  - Employers' Subscriptions and Compensation Cases.

PMID- 29839889
TI  - Early Treatment of Mental Cases: Proposed Use for Reception Homes and Observation
      Wards.

PMID- 29839890
TI  - The Visit of North American Surgeons.

PMID- 29839891
TI  - East Suffolk and Ipswich Hospital.

PMID- 29839892
TI  - The Clinical Congress of Surgeons of North America.

PMID- 29839893
TI  - Surgeons and Nurses: A Change in the Former's Behaviour.

PMID- 29839894
TI  - The Decay of Moral Force.

PMID- 29839895
TI  - Research and Remedies.

PMID- 29839896
TI  - The British Medical Association Meeting.

PMID- 29839897
TI  - Opening of a New Ward and Laboratory for Tropical Diseases.

PMID- 29839899
TI  - Hospital and Institutional News.

PMID- 29839898
TI  - The Secretaryship of St. Mark's.

PMID- 29839900
TI  - Institutional Organisation in America: III. Reforms in Gynaecological Out-Patient
      Clinics.

PMID- 29839901
TI  - Fellow-Workers and Their Doings.

PMID- 29839903
TI  - Poor-Law Infirmaries and the War.

PMID- 29839902
TI  - The Royal Portsmouth Hospital.

PMID- 29839904
TI  - The War and the Poor-Law Infirmaries.

PMID- 29839905
TI  - Buildings Contemplated.

PMID- 29839907
TI  - Hospital and Institutional News.

PMID- 29839906
TI  - The City of London.

PMID- 29839909
TI  - The Problem for Hospital Staffs and the Colleges.

PMID- 29839908
TI  - A Newcastle Hospital Pioneer.

PMID- 29839910
TI  - The Position of Sailors and Soldiers.

PMID- 29839911
TI  - Extemporised Hospitals.

PMID- 29839912
TI  - Quacks and the Bounds of Human Credulity.

PMID- 29839913
TI  - The Arrangements at Edinburgh and Dundee.

PMID- 29839914
TI  - Lord Haldane's Territorial Hospitals and Nursing Service.

PMID- 29839915
TI  - Fellow-Workers and Their Doings.

PMID- 29839916
TI  - Dr. Addison's New Post.

PMID- 29839917
TI  - A View of the Hospital Arrangements.

PMID- 29839918
TI  - Minor Hospital War News.

PMID- 29839919
TI  - Institutional Organisation in America: IV. Conundrums about Hospital Efficiency.

PMID- 29839920
TI  - What the Country Is Doing.

PMID- 29839922
TI  - Free Treatment for Those Affected.

PMID- 29839921
TI  - Linking up New Hospital Units.

PMID- 29839924
TI  - Medical Representatives on Insurance Committees.

PMID- 29839923
TI  - St. Mark's Hospital.

PMID- 29839925
TI  - Royal Hospital for Diseases of the Chest.

PMID- 29839926
TI  - The Colour Problem in Hospital Life.

PMID- 29839928
TI  - A Great City's Hospital Work.

PMID- 29839927
TI  - The Friendly Societies' Conferences.

PMID- 29839929
TI  - Dr. F. J. Waldo on Imperial and Local Government.

PMID- 29839930
TI  - Hospital and Institutional News.

PMID- 29839931
TI  - Strike of German Doctors.

PMID- 29839932
TI  - The Annual Meeting of the Poor-Law Medical Officers' Association of England and
      Wales.

PMID- 29839934
TI  - The British Medical Association in Scotland.

PMID- 29839933
TI  - Hospital Equipment.

PMID- 29839936
TI  - Institutional Organisations in America: I. Some Reforms in Children's Out-Patient
      Clinics.

PMID- 29839935
TI  - Hospital Plans and Their Selection.

PMID- 29839937
TI  - The Pure Milk Bills.

PMID- 29839938
TI  - British versus Continental Spas: A Plea for Home-Made Hydrotherapy.

PMID- 29839939
TI  - National Insurance and the Poorer Hospitals.

PMID- 29839940
TI  - Relations of Hospitals with Panel Practitioners: The London Panel Committee and
      the Budget Grants.

PMID- 29839941
TI  - Emetine in the Dysentery of Children.

PMID- 29839942
TI  - Proceedings at General Meeting.

PMID- 29839943
TI  - Buildings Contemplated and in Progress.

PMID- 29839944
TI  - Fellow-Workers and Their Doings.

PMID- 29839945
TI  - Reports on Hospitals of the United Kingdom: The North Evington Infirmary,
      Leicester: Report of the Guardians' Committee on Sir Henry Burdett's Report.

PMID- 29839946
TI  - The Nascent Iodine Treatment of Tuberculosis.

PMID- 29839947
TI  - The Glasgow Royal Infirmary Chairman.

PMID- 29839949
TI  - The Department of Modern Nursing: IV. West London Hospital.

PMID- 29839948
TI  - Graceful Giving.

PMID- 29839951
TI  - The Wage-Earning Value of the One-Eyed Man.

PMID- 29839950
TI  - Insurance Act Visitors.

PMID- 29839953
TI  - The Asylum Workers' Association: Speeches at the Annual Meeting.

PMID- 29839952
TI  - St. George's and the Westminster Hospitals.

PMID- 29839954
TI  - Buildings Contemplated.

PMID- 29839955
TI  - The Uckfield Cottage Hospital.

PMID- 29839956
TI  - Recurring Jaundice in Successive Pregnancies.

PMID- 29839957
TI  - Hospital and Institutional News.

PMID- 29839958
TI  - A Deportment Coronet.

PMID- 29839959
TI  - Forthcoming Developments Indicated in the Budget.

PMID- 29839960
TI  - Reports on Hospitals of the United Kingdom: Croydon General Hospital.

PMID- 29839961
TI  - The Staff at Gravesend Hospital.

PMID- 29839962
TI  - Two Bed-Lifters Described.

PMID- 29839964
TI  - The Orthopaedic Department: VII. The Plaster Room (continued). Modern Methods in
      Plaster Work.

PMID- 29839963
TI  - The Abuse of Tuberculin.

PMID- 29839965
TI  - The Royal, the Humorous, the Heroic.

PMID- 29839966
TI  - The Secret of Institutional Discipline.

PMID- 29839967
TI  - The National Medical Union (Official): Medical Forethought in State Medicine.

PMID- 29839968
TI  - Human Hibernation.

PMID- 29839969
TI  - Fellow-Workers and Their Doings.

PMID- 29839970
TI  - The Editor's Letter-Box.

PMID- 29839972
TI  - The Surgical Congress: July 27-31: Institutional Personalities.

PMID- 29839971
TI  - Treatment of Hay-Fever-Emetine in Tuberculosis.

PMID- 29839973
TI  - What Keeps a Man off the Panel?

PMID- 29839975
TI  - Perfunctory Exercises in Schools: The Inner Problem of Organised Games.

PMID- 29839974
TI  - The Future Relations of Medicine and the State.

PMID- 29839977
TI  - Relaxation by Aeroplane.

PMID- 29839976
TI  - A Year's Work at the Radium Institute.

PMID- 29839978
TI  - The Ward Locker Competition: The Successful Designs.

PMID- 29839979
TI  - The Risk of Premature Burial.

PMID- 29839980
TI  - The Inspection of Public Institutions.

PMID- 29839981
TI  - An Overlooked Factor in the Appeal for the Blind.

PMID- 29839982
TI  - The National Medical Union (Official): Final Meeting of Provisional Federating
      Council. The Profession of Medicine.

PMID- 29839983
TI  - Economy in the Generation and Use of Steam: I. Sources of Waste in the Older
      Boilers.

PMID- 29839984
TI  - London County Council Tuberculosis Scheme: The Position of the Hospitals.

PMID- 29839986
TI  - The Isolation Hospital Movement: An Authoritative Institutional Textbook.

PMID- 29839985
TI  - The Duration of Pregnancy.

PMID- 29839987
TI  - More about Abderhalden's Reaction.

PMID- 29839988
TI  - Fellow-Workers and Their Doings.

PMID- 29839990
TI  - Asylum Workers' Association.

PMID- 29839989
TI  - A Poor-Law Medical Officer and the Use of Brandy.

PMID- 29839992
TI  - Cost of Hospital Treatment Claimed from a Doctor.

PMID- 29839991
TI  - Panel Doctors and Professional Cowardice.

PMID- 29839994
TI  - The London Panel Committee.

PMID- 29839993
TI  - Reports on Hospitals of the United Kingdom: North Evington Poor-Law Infirmary,
      Leicester.

PMID- 29839995
TI  - A Linen Guild's Work at Leeds.

PMID- 29839996
TI  - Hospital and Institutional News.

PMID- 29839997
TI  - St. George's Hospital.

PMID- 29839998
TI  - A Speech Delivered on Behalf of Ancoats Hospital.

PMID- 29839999
TI  - What Keeps a Man off the Panel?

PMID- 29840000
TI  - Buildings Contemplated and in Progress.

PMID- 29840001
TI  - Legal Notes for Institutional Workers: A Mental Specialist's Fees-Education
      Authorities and Medical Associations-Bequest to an Attendant-A Point for Public
      Health Officers.

PMID- 29840003
TI  - Practical Points in Hospital Mechanics: The Control of Air Temperature by
      Thermostats.

PMID- 29840002
TI  - Mental Hospitals and After-Care.

PMID- 29840005
TI  - One Hundred and Thirty Patients a Day!

PMID- 29840004
TI  - Royal Chest Hospital Dinner.

PMID- 29840006
TI  - Heating by Gas.

PMID- 29840007
TI  - Reports on Hospitals of the United Kingdom: Margate Cottage Hospital. Royal Sea
      Bathing Hospital, Margate. Uckfield Cottage Hospital.

PMID- 29840008
TI  - Should the Chairmanship Go Round?

PMID- 29840010
TI  - Premature Burial.

PMID- 29840009
TI  - The Danger of a Short Sanatorium Course.

PMID- 29840012
TI  - Hospital Facts for an Interested Public.

PMID- 29840011
TI  - Hospital and Institutional News.

PMID- 29840014
TI  - The Department of Modern Nursing: St. Bartholomew's Hospital.

PMID- 29840013
TI  - The National Medical Union (Official): The London Organisation Committee.

PMID- 29840015
TI  - The Rural Workhouse Infirmary.

PMID- 29840016
TI  - The Marriage of Faith and Science.

PMID- 29840017
TI  - The History of St. George's Hospital: Some Eighteenth Century Institutional
      Officers.

PMID- 29840018
TI  - Fellow-Workers and Their Doings.

PMID- 29840019
TI  - The Facts of Syphilis on the Stage: Plays by an English Doctor and a French Poet.

PMID- 29840020
TI  - >The Tendency of Medico-Psychology: Freud's Theory and Its Critics.

PMID- 29840021
TI  - The London Clinical Congress.

PMID- 29840022
TI  - Doctors' Wills.

PMID- 29840023
TI  - Personalia.

PMID- 29840024
TI  - Reports on Hospitals of the United Kingdom: The Ashford Cottage Hospital.

PMID- 29840025
TI  - The Welchman Memorial Hospital, Guadalcanar.

PMID- 29840026
TI  - Personalia.

PMID- 29840027
TI  - The Complexity of Diphtheria Toxin.

PMID- 29840028
TI  - The Future of the Deposit Contributor.

PMID- 29840029
TI  - Institutional Needs.

PMID- 29840030
TI  - A Unique Hospital Chapel.

PMID- 29840031
TI  - Fellow-Workers and Their Doings.

PMID- 29840032
TI  - An Aid to Prognosis for the School Doctor.

PMID- 29840033
TI  - Their Place in the Hospital Budget.

PMID- 29840034
TI  - Good Work Done and More to Follow at Leicester.

PMID- 29840035
TI  - Hospital and Institutional News.

PMID- 29840037
TI  - The Government of the Royal College of Surgeons.

PMID- 29840036
TI  - Women Doctors and the London County Council.

PMID- 29840038
TI  - The Editor's Letter-Box.

PMID- 29840039
TI  - The "Cardiac Sign" of Malignant Disease.

PMID- 29840040
TI  - Doctors' Wills.

PMID- 29840041
TI  - The Diary of a "Chronic Appendix".

PMID- 29840042
TI  - The National Medical Union (Official): Dr. Macevoy on the Constitution.

PMID- 29840043
TI  - The Editor's Letter-Box.

PMID- 29840044
TI  - Non-Panel Men and the "Medical Directory".

PMID- 29840045
TI  - The Picture Palace and the Spread of Disease.

PMID- 29840046
TI  - Their Desirability in General Hospitals.

PMID- 29840047
TI  - The National Medical Union (Official): Meeting of Executive Committee. Sanatorium
      Benefit Statistics.

PMID- 29840048
TI  - Non-Panel Men and the "Medical Directory".

PMID- 29840049
TI  - Public Pharmacists' Bohemian Concert.

PMID- 29840050
TI  - The Passing of Parasyphilis.

PMID- 29840051
TI  - Hospital and Institutional News.

PMID- 29840052
TI  - A Disclaimer.

PMID- 29840053
TI  - In an Urban District Infectious Hospital.

PMID- 29840055
TI  - Boy Scouts and a Hospital Toy Service.

PMID- 29840054
TI  - Imperial Health Conference.

PMID- 29840056
TI  - Treatment by Tuberculin.

PMID- 29840057
TI  - How to Vote.

PMID- 29840058
TI  - The Latest Treatment for Eclampsia.

PMID- 29840059
TI  - Neo-Salvarsan for Scarlet Fever.

PMID- 29840060
TI  - The National Insurance Act (Part II.) Amendment Bill.

PMID- 29840061
TI  - Fellow-Workers and Their Doings.

PMID- 29840062
TI  - Our First Competition.

PMID- 29840063
TI  - Annual Meeting of Governors and General Council.

PMID- 29840065
TI  - The Treatment of Cancer of the Cervix Uteri: Wertheim's Operation, the Bumm and
      Werder Methods.

PMID- 29840064
TI  - Personalia.

PMID- 29840066
TI  - Reports on Hospitals of the United Kingdom: West Kent General Hospital,
      Maidstone.

PMID- 29840067
TI  - The Strength of Metropolitan Voluntary Hospitals.

PMID- 29840068
TI  - The Voting Paper and the Prizes.

PMID- 29840069
TI  - Suggestions for an Ideal Locker: The Six Selected Designs.

PMID- 29840070
TI  - Hospitals from the Patients' Point of View: Three Weeks in a Pay-Ward.

PMID- 29840071
TI  - Buildings Contemplated and in Progress.

PMID- 29840072
TI  - Synthetic Germs.

PMID- 29840073
TI  - Fellow-Workers and Their Doings.

PMID- 29840075
TI  - Doctors' Wills.

PMID- 29840074
TI  - A Novel Request.

PMID- 29840076
TI  - A Question of Professional Conduct.

PMID- 29840077
TI  - The Newcastle Conference: The Place and Personalities of the Week.

PMID- 29840078
TI  - Working-Class Support and Representation.

PMID- 29840079
TI  - Common Errors in Diagnosis: The Chest.

PMID- 29840080
TI  - The Council Election of the English Royal College of Surgeons.

PMID- 29840081
TI  - Hospital and Institutional News.

PMID- 29840083
TI  - The Question of Linked-Up Illnesses.

PMID- 29840082
TI  - Medical Etiquette Tested by Practice.

PMID- 29840084
TI  - The Tuberculosis Society.

PMID- 29840085
TI  - Institutional Needs.

PMID- 29840086
TI  - Hospital Advertising.

PMID- 29840088
TI  - Institutional Defalcations: The Assistant Secretary's Responsibility.

PMID- 29840087
TI  - Reports on Hospitals of the United Kingdom: The Epsom and Ewell Cottage Hospital.
      Faversham Cottage Hospital.

PMID- 29840089
TI  - The Failure of Incipient Insanity Bills.

PMID- 29840090
TI  - Personalia.

PMID- 29840092
TI  - Acrosyl.

PMID- 29840091
TI  - Hospital and Institutional News.

PMID- 29840093
TI  - The National Insurance (Navy and Army) Act, 1914: The Position of Lord
      Kitchener's Armies.

PMID- 29840094
TI  - Reports on Hospitals of the United Kingdom: The Cumberland Infirmary, Carlisle.

PMID- 29840095
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29840096
TI  - Buildings Contemplated.

PMID- 29840097
TI  - "What Can I Do to Help My Country?": Defend the Families of Our Sailors and
      Soldiers.

PMID- 29840098
TI  - Committees and the Shortage of Resident Medical Officers : Is There Shortage?

PMID- 29840099
TI  - The War and Professional Prospects: The Outlook for Education and Practice.

PMID- 29840100
TI  - The After-Histories of Sanatorium Patients: A Report from Frimley.

PMID- 29840101
TI  - Losses in the Royal Army Medical Corps.

PMID- 29840102
TI  - Open-Air Hospitals in War-Time.

PMID- 29840103
TI  - Soldiers in the Provincial Hospitals.

PMID- 29840104
TI  - Our Warriors' Dependants and "Relief".

PMID- 29840105
TI  - Radium in Deafness: Hyoscine Injections and a Captious Critic.

PMID- 29840106
TI  - The Orthopaedic Department: VI. The Plaster Room.

PMID- 29840107
TI  - Infant Hygiene in the Medical Curriculum.

PMID- 29840108
TI  - Concerning the First Rib.

PMID- 29840109
TI  - Actual Results of the Test.

PMID- 29840111
TI  - The Harrow Cottage Hospital: Its Architecture and Its Critics.

PMID- 29840110
TI  - The Editor's Letter-Box.

PMID- 29840112
TI  - Maternity Homes in Industrial Life: The State and the Environment of Pregnancy.

PMID- 29840113
TI  - Doctor's Precaution against Premature Burial.

PMID- 29840114
TI  - The King Edward VII. Sanatorium Report.

PMID- 29840115
TI  - The Diagnosis of Paternity.

PMID- 29840116
TI  - Buildings Contemplated.

PMID- 29840117
TI  - Recovery from Sleeping Sickness.

PMID- 29840118
TI  - Reports on Hospitals of the United Kingdom: Ramsgate General Hospital and
      Seamen's Infirmary.

PMID- 29840119
TI  - Colloid Metals in Therapeutics.

PMID- 29840120
TI  - Salaries of Poor-Law Medical Officers.

PMID- 29840122
TI  - The National Medical Union (Official): The Constitution Committee's
      Recommendations.

PMID- 29840121
TI  - The Editor's Letter-Box.

PMID- 29840123
TI  - The Patients' Column.-III. A London and a Provincial General Hospital Experience.

PMID- 29840124
TI  - The Problem of Syphilis in Poor-Law Infirmaries.

PMID- 29840125
TI  - A Workpeople's Gathering at Leicester.

PMID- 29840126
TI  - Hospital and Institutional News.

PMID- 29840127
TI  - Personalia.

PMID- 29840128
TI  - Fellow-Workers and Their Doings.

PMID- 29840129
TI  - Non-Panel Men and the "Medical Directory".

PMID- 29840131
TI  - Doctors' Wills.

PMID- 29840132
TI  - Drinking-Water and Dental Caries.

PMID- 29840130
TI  - Colloid Metals.

PMID- 29840134
TI  - Institutional Needs.

PMID- 29840133
TI  - Committees and the Shortage of Resident Officers.

PMID- 29840135
TI  - Physical Fitness and Military Efficiency: Are the Medical Tests for Recruits Too
      Severe?

PMID- 29840136
TI  - Reception of the Wounded at St. Thomas's Hospital.

PMID- 29840137
TI  - The Provincial Hospitals' Arrangements: Bristol, Cambridge-Chatham District:
      German Prisoners-Gravesend-Ipswich-Leicester: Arrival of Wounded-Leamington Spa
      Manchester Men on Active Service-Middlesbrough-Norwich-The Temporary Wards at
      Newcastle-Sheffield: Wounded from Mons-Tunbridge Wells and District.

PMID- 29840139
TI  - An Exposure of Quackery: The Select Committee's Report on Patent Medicines.

PMID- 29840138
TI  - Managers and Statutory Funds.

PMID- 29840140
TI  - View of a London Secretary.

PMID- 29840141
TI  - Arrangements in Edinburgh and Dundee: Dundee-Edinburgh: Arrival of Navy Men.

PMID- 29840142
TI  - Buildings Contemplated.

PMID- 29840143
TI  - Fellow-Workers and Their Doings.

PMID- 29840145
TI  - Our Sick and Wounded Home Again.

PMID- 29840144
TI  - Hospital and Institutional News.

PMID- 29840146
TI  - The After-Care of the Wounded.

PMID- 29840147
TI  - A Judge on Medical Witnesses' Fees.

PMID- 29840148
TI  - The Welsh War Hospital Scheme.

PMID- 29840149
TI  - Motor-Car Cots.

PMID- 29840150
TI  - The Voluntary Hospital: On Its Trial.

PMID- 29840151
TI  - Buildings Contemplated and in Progress.

PMID- 29840152
TI  - A Research Ward at St. Thomas's Hospital.

PMID- 29840153
TI  - Fifth Annual Conference at Newcastle-On-Tyne, June 18 to 20, 1914.

PMID- 29840154
TI  - The Chamberlain Memorial: Mr. Harcourt at the Albert Dock Hospital.

PMID- 29840155
TI  - Fellow-Workers and Their Doings.

PMID- 29840156
TI  - The Hospital Conference at Newcastle: Some Lessons and Suggestions.

PMID- 29840157
TI  - The Voluntary Hospital: The Discussion.

PMID- 29840158
TI  - The Reply by Dr. Hume.

PMID- 29840160
TI  - Some Hospitals and Municipal Institutions.

PMID- 29840159
TI  - Competitive Designs at Burnley.

PMID- 29840161
TI  - Lord Knutsford and Sir Victor Horsley.

PMID- 29840163
TI  - The Voluntary Hospitals and Grants in Aid.

PMID- 29840162
TI  - Hospital and Institutional News.

PMID- 29840165
TI  - Hospital Plans and Their Selection: Right and Wrong Methods: A Case in Point.

PMID- 29840164
TI  - The New Pharmacopoeia.

PMID- 29840167
TI  - Anti-Typhoid Inoculation in the Army.

PMID- 29840166
TI  - The Shortage of Medical Officers: An Appeal to the Colonies.

PMID- 29840168
TI  - Hospital and Institutional News.

PMID- 29840169
TI  - Good Ambulance Work in Glasgow.

PMID- 29840171
TI  - Tuberculosis Pavilions at Isolation Hospitals: Problems Involved in the Present
      Arrangements.

PMID- 29840170
TI  - Free Treatment with Free Medicine.

PMID- 29840173
TI  - The Work of London Hospitals and Infirmaries. West End Hospital: News from the
      Staff in Belgium-A London Secretary as Artillery Officer-New Headquarters of
      British Red Cross Society-Homerton and Bow Infirmaries.

PMID- 29840172
TI  - Public Grants to Schools for Mothers: The Board of Education's Proposals.

PMID- 29840174
TI  - The Belgian Refugees at Alexandra Palace: Dr. H. Cuff, Medical Superintendent, on
      Emergency Administration.

PMID- 29840175
TI  - Cottage Hospital, Staines.

PMID- 29840176
TI  - Soldiers in the Provincial Hospitals: Ashton-Under-Lyne: Anti-Typhoid Inoculation
      Bradford-Bristol: Supplementary Hospital-Cambridge: New Quarters of the 1st
      Eastern General Hospital-Gravesend and District-Leicester: Further Wounded Arrive
      Lincoln: 110 Wounded Received-Sheffield: Embarrassing Sympathisers.

PMID- 29840178
TI  - The Beginnings of the London Hospital: A New Light on Its Early Days.

PMID- 29840177
TI  - Personalia.

PMID- 29840180
TI  - A Scientific Mattress.

PMID- 29840179
TI  - The Lesson of the Metropolitan Asylums Board Report.

PMID- 29840181
TI  - Buildings Contemplated.

PMID- 29840182
TI  - Hospital Appeals in Time of War.

PMID- 29840183
TI  - Fellow-Workers and the Roll of Honour.

PMID- 29840184
TI  - What Should Our Policy Be?

PMID- 29840185
TI  - The Legal Position in Maternity Cases: The Law, the Nurse, and the Compromise.

PMID- 29840186
TI  - The Drain on the Hospitals' Special Departments.

PMID- 29840187
TI  - The Equipment of Emergency Hospitals.

PMID- 29840188
TI  - The London Hospitals' Arrangements: St. Bartholomew's Hospital-West Ham and
      Eastern General Hospital-The London.

PMID- 29840189
TI  - Organisation and Control.

PMID- 29840190
TI  - Schools for Mothers.

PMID- 29840191
TI  - The Red Cross Society: The Red Cross Expedition to Belgium-The Red Cross Motor
      Car Corps-Progress of the Arrangements for Stores-The War Office and Private
      Offers-A Link between Firing Line and Hospital-How Offers of Help Are Dealt With
      A Lady-Resident Volunteers-Red Cross Work at Cambridge-The Hospital Unit at
      Greenwich for Receiving Wounded in the Thames.

PMID- 29840192
TI  - The Heart of the British People.

PMID- 29840193
TI  - Poor-Law Infirmaries and the War Office: Birkenhead-Offers of Poor-Law
      Institutions-South Shields-An East Coast Town's Preparations.

PMID- 29840194
TI  - Temporary Hospital Provision in War-Time.

PMID- 29840195
TI  - A Noted Worker at Oldham.

PMID- 29840196
TI  - Minor Hospital War News.

PMID- 29840197
TI  - The Rights of the Civil Population.

PMID- 29840199
TI  - Scotch Servants and Hospital Problems.

PMID- 29840198
TI  - Preparations in Scotland: Aberdeen, Glasgow, and Perth-Kilmarnock-Stirling-The
      Scottish Red Cross Society.

PMID- 29840201
TI  - Hospital and Institutional News.

PMID- 29840200
TI  - The War and University Studies.

PMID- 29840202
TI  - Hospitals and the War: Brighton.

PMID- 29840203
TI  - Provincial Hospital Arrangements: Aylesbury-Barnsley-Chatham District-Coventry
      and Warwickshire Hospital-Croydon-Doncaster and District-Felixstowe-Gloucester
      Gravesend: An Emergency Test-Lancaster-Leamington-Salisbury Infirmary-St.
      Leonards, Hastings-Wakefield and District-Wolverhampton.

PMID- 29840204
TI  - Fellow-Workers and Their Doings.

PMID- 29840205
TI  - The Fellowship of the Royal College of Surgeons.

PMID- 29840206
TI  - The Royal Army Medical Corps: A Review of the Prospects and Pay.

PMID- 29840208
TI  - Higher Diplomas.

PMID- 29840207
TI  - Provincial Schools.

PMID- 29840210
TI  - The Royal Naval Medical Service: What It Offers to the Newly Qualified Medical
      Man.

PMID- 29840209
TI  - Qualification and Registration.

PMID- 29840211
TI  - The English Conjoint Course.

PMID- 29840212
TI  - Opportunities for Graduate Study in Special Hospitals.

PMID- 29840213
TI  - The Poor-Law Service and the War.

PMID- 29840214
TI  - The London University Course.

PMID- 29840215
TI  - London Post-Graduate Institutions: West London Post-Graduate College-The London
      Polyclinic-The London School of Clinical Medicine (Post-Graduate)-North-East
      London Post-Graduate College.

PMID- 29840216
TI  - Hospital and Institutional News.

PMID- 29840217
TI  - Royal Naval Medical Service.

PMID- 29840218
TI  - Scotland.

PMID- 29840219
TI  - London.

PMID- 29840220
TI  - The Cambridge University Course.

PMID- 29840221
TI  - Life in the Indian Medical Service: The Attractions of Medicine and Sport.

PMID- 29840222
TI  - Oxford University.

PMID- 29840223
TI  - The Study of Tropical Medicine in London, Liverpool, and Edinburgh.

PMID- 29840224
TI  - The Indian Medical Service.

PMID- 29840226
TI  - The Provincial Hospitals' Arrangements: Bath-Bradford-Leeds-Leicester-Lincoln
      North Devon Division-Sheffield.

PMID- 29840225
TI  - Personalia.

PMID- 29840228
TI  - War Patients at the Hospital.

PMID- 29840227
TI  - The Colonial Medical Service.

PMID- 29840229
TI  - Institutional Needs.

PMID- 29840230
TI  - The Royal Army Medical Corps.

PMID- 29840231
TI  - Ireland.

PMID- 29840232
TI  - Medicine as a Career.

PMID- 29840233
TI  - Reports on Hospitals of the United Kingdom: Kent County Ophthalmic Hospital,
      Maidstone.

PMID- 29840234
TI  - The "Jenner" Lifting Pole.

PMID- 29840235
TI  - The Risk of Premature Burial.

PMID- 29840236
TI  - Co-Operation Centres, Prescribing and Fees.

PMID- 29840237
TI  - The Romance of Camphor.

PMID- 29840239
TI  - The Hampshire Tuberculosis Officership.

PMID- 29840238
TI  - Institutional Defalcations : The Assistant-Secretary's Responsibility.

PMID- 29840241
TI  - Economy in the Generation and Use of Steam: II. The Principal Apparatus
      Described.

PMID- 29840240
TI  - Pharmacists and the Cocaine Snuff Habit.

PMID- 29840242
TI  - The Retrograde Policy of the Bath Guardians.

PMID- 29840243
TI  - Buildings Contemplated.

PMID- 29840244
TI  - The Patients' Column.

PMID- 29840245
TI  - A Question of Professional Conduct.

PMID- 29840247
TI  - Trade Hostility to Hospital Research: The Ideal Antiseptic for Obstetric Work.

PMID- 29840246
TI  - Major Surgery and Human Character : A Novel.

PMID- 29840248
TI  - New Developments at "The London": Mr. W. T. Paulin on the Effect of the Insurance
      Act.

PMID- 29840249
TI  - Hospital and Institutional News.

PMID- 29840251
TI  - Old-Age and Eyesight.

PMID- 29840250
TI  - A Radium Week by Artizan Workers.

PMID- 29840252
TI  - The National Medical Union (Official).

PMID- 29840254
TI  - Mental Symptoms and Patients' Thoughts: The Methods of Psycho-Analysis.

PMID- 29840253
TI  - The Prevention of Typhoid Fever.

PMID- 29840256
TI  - The Laymen's Influence in Public Medicine.

PMID- 29840255
TI  - Symptoms That May Lead to the Police Court.

PMID- 29840257
TI  - The London Hospital.

PMID- 29840258
TI  - Should Surgeons Mask While Operating? The Deadliness of a Sneeze.

PMID- 29840259
TI  - Legal Notes for Institutional Workers.

PMID- 29840260
TI  - Institutional Residents and Recreation: The Escape from the Common-Room
      Atmosphere.

PMID- 29840262
TI  - Fellow-Workers and Their Doings.

PMID- 29840261
TI  - Colloid Metals in the Clinical Laboratory.

PMID- 29840263
TI  - Parliament and Publications.

PMID- 29840264
TI  - The Week's Work.

PMID- 29840265
TI  - Annotations.

PMID- 29840266
TI  - The Abuse of the Hospital and Its Cure.

PMID- 29840267
TI  - The Meaning of Diathesis.

PMID- 29840268
TI  - Ionic Medication.

PMID- 29840270
TI  - Mob Psychology.

PMID- 29840269
TI  - The Hospital World.

PMID- 29840272
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29840271
TI  - Medical Opinion and Movement.

PMID- 29840273
TI  - News and Events of the Week.

PMID- 29840274
TI  - Institutional Notes and News.

PMID- 29840276
TI  - Tubercle Bacilli in the Faeces in Tuberculosis.

PMID- 29840275
TI  - The Treatment of Everyday Cases-Headache.

PMID- 29840277
TI  - Some Notes on the Treatment of Puerperal Septic Disease.

PMID- 29840278
TI  - Some Common Causes of Pain in the Foot-II.

PMID- 29840279
TI  - On a Fatal Variety of Ulcerative Sore-Throat.

PMID- 29840281
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29840280
TI  - A Case of Hysterical Photophobia in a Child.

PMID- 29840282
TI  - New Appliances and Things Medical.

PMID- 29840283
TI  - Medical Opinion and Movement.

PMID- 29840284
TI  - Annotations.

PMID- 29840285
TI  - Inflammation of the Iris.

PMID- 29840286
TI  - Parliament and Publications.

PMID- 29840287
TI  - The Ethnology of the American Medical Profession.

PMID- 29840288
TI  - The Hospital World.

PMID- 29840289
TI  - Hospital Contracts and Prices.

PMID- 29840290
TI  - News and Events of the Week.

PMID- 29840292
TI  - Institutional Notes and News.

PMID- 29840291
TI  - The Social Policy of Voluntary Hospitals.

PMID- 29840294
TI  - The Week's Work.

PMID- 29840293
TI  - An Epitome of Pediatrics.

PMID- 29840296
TI  - The Nationalisation of the Profession.

PMID- 29840295
TI  - The Heritage School of Arts and Crafts for Crippled Boys, Chailey, Sussex.

PMID- 29840297
TI  - The Modern Treatment of Fractures.

PMID- 29840298
TI  - Galvanic Treatment for Comedones.

PMID- 29840299
TI  - Institutional Notes and News.

PMID- 29840300
TI  - Human Botryomycosis.

PMID- 29840301
TI  - Annotations.

PMID- 29840302
TI  - Unqualified Medical Practice.

PMID- 29840303
TI  - Death and Dying in Plastic and Pictorial Art.

PMID- 29840304
TI  - The Problems of Nephritis.

PMID- 29840305
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29840306
TI  - Medical Opinion and Movement.

PMID- 29840307
TI  - The Hospital World.

PMID- 29840308
TI  - The Week's Work.

PMID- 29840310
TI  - News and Events of the Week.

PMID- 29840309
TI  - The Need of an Intermediate Single-Room Service in Hospitals.

PMID- 29840312
TI  - Insects as Carriers of Tropical Diseases.

PMID- 29840311
TI  - The Bacillus Influenzae.

PMID- 29840314
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29840313
TI  - Parliament and Publications.

PMID- 29840315
TI  - Medicated Squab Pie.

PMID- 29840316
TI  - Hospital Medical Schools and the King's Fund.

PMID- 29840317
TI  - The Park Hospital for Sick Children.

PMID- 29840319
TI  - Tuberculosis of the Air-Passages above the Larynx.

PMID- 29840318
TI  - A Simple and Efficient Method of Removing Tonsils.

PMID- 29840320
TI  - By the Way.

PMID- 29840321
TI  - Annotations.

PMID- 29840323
TI  - The Practitioner: Reputed and Actual.

PMID- 29840322
TI  - The League of Mercy.

PMID- 29840324
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29840325
TI  - Meals for Necessitous School Children during the Christmas Holidays.

PMID- 29840326
TI  - Nature Notes-VIII.

PMID- 29840328
TI  - The Week's Work.

PMID- 29840327
TI  - The Compilation of a Local History.

PMID- 29840329
TI  - Colonial Drugs.

PMID- 29840330
TI  - The Week in the Courts.

PMID- 29840332
TI  - Parliament and Publications.

PMID- 29840331
TI  - Hospital Medical Schools and the King's Fund.

PMID- 29840333
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29840334
TI  - The Newcastle Infirmary Resignations.

PMID- 29840336
TI  - Erratum.
AB  - [This corrects the article on p. 335 in vol. 49.].

PMID- 29840335
TI  - Institutional Notes and News.

PMID- 29840337
TI  - News and Events of the Week.

PMID- 29840338
TI  - The Hospital World.

PMID- 29840339
TI  - A Medical Worthy of the Early Eighteenth Century.

PMID- 29840340
TI  - The Stethoscope.

PMID- 29840342
TI  - Institutional Notes and News.

PMID- 29840341
TI  - Humanitarianism.

PMID- 29840343
TI  - Medical Opinion and Movement.

PMID- 29840344
TI  - Parliament and Publications.

PMID- 29840345
TI  - The King's Fund and Hospital Medical Schools.

PMID- 29840346
TI  - Annotations.

PMID- 29840348
TI  - The New Parliament.

PMID- 29840347
TI  - Quack Advertisements.

PMID- 29840349
TI  - The AEtiology of Hydrophobia.

PMID- 29840350
TI  - The Week in the Courts.

PMID- 29840351
TI  - News and Events of the Week.

PMID- 29840352
TI  - The Week's Work.

PMID- 29840353
TI  - Orthopaedics in General Practice.

PMID- 29840354
TI  - The Hospital World.

PMID- 29840355
TI  - Carbon Monoxide Poisoning on a Motor Launch.

PMID- 29840356
TI  - Radiography.

PMID- 29840357
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29840359
TI  - News and Events of the Week.

PMID- 29840358
TI  - King Edward's Hospital Fund for London.

PMID- 29840361
TI  - The Week's Work.

PMID- 29840360
TI  - The Care of the Feeble-Minded at Leicester.

PMID- 29840362
TI  - After-Results of Magnet Extraction.

PMID- 29840363
TI  - Coma Due to Acute Yellow Atrophy of the Liver.

PMID- 29840365
TI  - The Physical Signs of Enlargement of the Gall-Bladder.

PMID- 29840364
TI  - Medical Opinion and Movement.

PMID- 29840367
TI  - Hospital Medical Schools and the King's Fund.

PMID- 29840366
TI  - The State Children's Association.

PMID- 29840369
TI  - Public Grants for Voluntary Hospitals.

PMID- 29840368
TI  - Parliament and Publications.

PMID- 29840370
TI  - Annotations.

PMID- 29840371
TI  - Some Prescription Difficulties.

PMID- 29840372
TI  - Demonstration of Cases of Nervous Disease.

PMID- 29840373
TI  - New Appliances and Things Medical.

PMID- 29840374
TI  - Medical Reasons for Divorce.

PMID- 29840375
TI  - A Study in Economic Medicine.

PMID- 29840377
TI  - Institutional Notes and News.

PMID- 29840376
TI  - The Hospital World.

PMID- 29840379
TI  - The Typhoid Carrier.

PMID- 29840378
TI  - An American View of State Aid for Hospitals.

PMID- 29840381
TI  - On the Use of Plasters in Dermatology.

PMID- 29840380
TI  - Eminent Chairman Series: III. Mr. Cosmo Bonsor, D.L.

PMID- 29840382
TI  - Women's Work in War.

PMID- 29840384
TI  - Workmen's Compensation Cases.

PMID- 29840383
TI  - Essex County Hospital.

PMID- 29840385
TI  - Medical Opinion and Movement.

PMID- 29840386
TI  - The Hospital World.

PMID- 29840388
TI  - New Appliances and Things Medical.

PMID- 29840387
TI  - Parliament and Publications.

PMID- 29840389
TI  - The Enteric Fever "Carrier".

PMID- 29840391
TI  - The Early Recognition of Measles.

PMID- 29840390
TI  - The Prognosis of Cancer.

PMID- 29840392
TI  - News and Events of the Week.

PMID- 29840393
TI  - The St. John Ambulance Association and the Voluntary Aid Detachments.

PMID- 29840394
TI  - The Week's Work.

PMID- 29840395
TI  - Institutional Notes and News.

PMID- 29840396
TI  - Annotations.

PMID- 29840397
TI  - New Appliances and Things Medical.

PMID- 29840398
TI  - Australian Notes.

PMID- 29840399
TI  - Institutional Notes and News.

PMID- 29840400
TI  - Difficulties in Removing the Tracheotomy Tube after Diphtheria.

PMID- 29840401
TI  - Medical Opinion and Movement.

PMID- 29840402
TI  - Public Grants for Voluntary Hospitals.

PMID- 29840403
TI  - The Week's Work.

PMID- 29840405
TI  - Parliament and Publications: The Hospitals of Kedah.

PMID- 29840404
TI  - Multiple Crises in Tabes Dorsalis.

PMID- 29840406
TI  - North Midland Poor-Law Conference.

PMID- 29840407
TI  - Royal Albert Edward Infirmary, Wigan, New Mortuary.

PMID- 29840409
TI  - The Coming of a Unified County Medical Service, and How It Will Affect the
      Voluntary Hospital.

PMID- 29840408
TI  - News and Events of the Week.

PMID- 29840410
TI  - Haematology-IX.

PMID- 29840411
TI  - Medical Tuition by Correspondence.

PMID- 29840412
TI  - Melanuria.

PMID- 29840413
TI  - The Hospital World.

PMID- 29840414
TI  - Annotations.

PMID- 29840415
TI  - Mental Evolution and the Insanities of To-Day.

PMID- 29840417
TI  - Severe Poisoning by Homatropin Used as an Eye Instillation.

PMID- 29840416
TI  - The Crippen Case.

PMID- 29840418
TI  - Erratum: The Treatment of Everyday Cases-Headache.
AB  - [This corrects the article on p. 107 in vol. 49.].

PMID- 29840419
TI  - The Danger of Flannelette.

PMID- 29840420
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29840422
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29840421
TI  - Osteopathy.

PMID- 29840423
TI  - Inflammation of the Iris.

PMID- 29840424
TI  - Osteopathy.

PMID- 29840425
TI  - Identity of the Living and Dead.

PMID- 29840426
TI  - The Spread of Poliomyelitis in America.

PMID- 29840427
TI  - Inquests after Operations.

PMID- 29840428
TI  - Annotations.

PMID- 29840430
TI  - The Hebrew Physicians of Mediaeval Avignon.

PMID- 29840429
TI  - Tinea Cruris.

PMID- 29840432
TI  - News and Events of the Week.

PMID- 29840431
TI  - The British Hospitals Association.

PMID- 29840434
TI  - The Hospital World.

PMID- 29840433
TI  - The Green Lady Hostel.

PMID- 29840435
TI  - Parliament and Publications.

PMID- 29840436
TI  - Scottish Asylums.

PMID- 29840438
TI  - The Croydon Cottage Hospital for Felixstowe and Walton.

PMID- 29840437
TI  - The Week's Work.

PMID- 29840439
TI  - The Legal Relations of Hospital, Hospital Staff, and Patient.

PMID- 29840440
TI  - Institutional Notes and News.

PMID- 29840441
TI  - Medical Opinion and Movement.

PMID- 29840442
TI  - The Importance of Examining the Teeth.

PMID- 29840444
TI  - The Medical Year.

PMID- 29840443
TI  - The Microbacillus of Acne.

PMID- 29840446
TI  - The Evolution of Joint Surgery.

PMID- 29840445
TI  - Style in Medical Authorship.

PMID- 29840447
TI  - "The West London Appointment": an Official Disclaimer.

PMID- 29840448
TI  - German Hospital, Dalston.

PMID- 29840449
TI  - The Height of Antisepsis.

PMID- 29840451
TI  - Parliament and Publications.

PMID- 29840450
TI  - Vincent's Angina.

PMID- 29840453
TI  - News and Events of the Week.

PMID- 29840452
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29840455
TI  - "The West London Appointment": an Official Disclaimer.

PMID- 29840454
TI  - The Anaesthetist's Outfit.

PMID- 29840456
TI  - Hospital Relief in Holland.

PMID- 29840458
TI  - An Advance Announcement.

PMID- 29840457
TI  - Royal Southern Hospital, Liverpool.

PMID- 29840460
TI  - The Week's Work.

PMID- 29840459
TI  - Medical Opinion and Movement.

PMID- 29840461
TI  - Annotations.

PMID- 29840462
TI  - Institutional Notes and News.

PMID- 29840463
TI  - Grain Itch.

PMID- 29840464
TI  - The Hospital World.

PMID- 29840465
TI  - The Question Box.

PMID- 29840466
TI  - Some Untoward Consequences of Phimosis and of Circumcision.

PMID- 29840467
TI  - New Appliances and Things Medical.

PMID- 29840468
TI  - Epidemic Parotitis.

PMID- 29840469
TI  - The Westminster Hospital Medical School.

PMID- 29840470
TI  - A Clinical Lecture on Stone in the Ureter.

PMID- 29840472
TI  - The Week's Work.

PMID- 29840471
TI  - The Hospital World.

PMID- 29840473
TI  - Medical Opinion and Movement.

PMID- 29840475
TI  - Annotations.

PMID- 29840474
TI  - Hospitals and Insurance Systems.

PMID- 29840477
TI  - The Middlesex Hospital Appeal.

PMID- 29840476
TI  - News and Events of the Week.

PMID- 29840479
TI  - The Significance of Pericardial Fluid in Cases of Presumed Overlying.

PMID- 29840478
TI  - A New Treatment for Impetigo Contagiosa.

PMID- 29840481
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29840480
TI  - Institutional Notes and News.

PMID- 29840483
TI  - Forty Years of Lunacy Work.

PMID- 29840482
TI  - Parliament and Publications.

PMID- 29840485
TI  - National Children's Home and Orphanage Sanatorium, Harpenden.

PMID- 29840484
TI  - Authority versus Independence in Medicine.

PMID- 29840487
TI  - The Middlesex Hospital Appeal.

PMID- 29840486
TI  - New Appliances and Things Medical.

PMID- 29840489
TI  - The Modern Medical Journal.

PMID- 29840488
TI  - Voluntary Work and the Voluntary Hospitals.

PMID- 29840491
TI  - A Bird-Watcher's Camp-III.

PMID- 29840490
TI  - A New Field of Medical Treatment.

PMID- 29840492
TI  - Relaxations and Hobbies.

PMID- 29840493
TI  - Some Appreciations and a Suggestion.

PMID- 29840494
TI  - Mr. Percy Raiment and Mr. Gordon R. Ward.

PMID- 29840495
TI  - Hospital Statistics: Some Criticisms and Suggestions.

PMID- 29840496
TI  - Present Tendencies and Future Developments.

PMID- 29840498
TI  - The Gas Exhibition. II.-Institutional Applications Demonstrated.

PMID- 29840497
TI  - Quinine as a Hypnotic.

PMID- 29840499
TI  - The Value of Petrol at Operations.

PMID- 29840500
TI  - National Insurance: The Distribution of the Medical Benefit Fund.

PMID- 29840501
TI  - The Non-Panel Movement.

PMID- 29840502
TI  - Recent Advances in Orthopaedics.

PMID- 29840503
TI  - The Future Tuberculosis Institution Resident.

PMID- 29840504
TI  - Telephones for Hospital Use.

PMID- 29840505
TI  - Hospital and Institutional News.

PMID- 29840507
TI  - German and English Medical Education.

PMID- 29840506
TI  - The Hospital Isolation of Infectious Diseases: IV. Administrative Difficulties in
      Small Isolation Hospitals.

PMID- 29840508
TI  - Red Cross Uses of Aerial Transport.

PMID- 29840509
TI  - The Bacteriology of Food Poisoning: "Ptomaine Poisoning" and Modern Research.

PMID- 29840510
TI  - Worcester Infirmary and the Jubilee Fund.

PMID- 29840511
TI  - Legal Notes for Institutional Workers.

PMID- 29840512
TI  - The Unsatisfactory Panel System.

PMID- 29840513
TI  - Buildings Contemplated and in Progress.

PMID- 29840514
TI  - Personalia.

PMID- 29840515
TI  - Certificates for Hospital Life Governors.

PMID- 29840516
TI  - Hospital and Institutional News.

PMID- 29840517
TI  - Insurance Sanatorium Construction: Hints to Architects by a Sanatorium
      Superintendent.

PMID- 29840518
TI  - The Lesson of the Manchester System.

PMID- 29840519
TI  - Blind-Alley Hospital Employments: The Case of the Laboratory Boy.

PMID- 29840520
TI  - Institutional Needs.

PMID- 29840521
TI  - The Bane of Influence in Phthisis Work.

PMID- 29840522
TI  - New Admission Block at Royal Victoria Infirmary, Newcastle.

PMID- 29840523
TI  - The British Medical Association and Its Critics.

PMID- 29840524
TI  - The Salvation Army Mothers' Hospital.

PMID- 29840525
TI  - Present and Future of the Poor-Law Infirmary: The Resident Medical Officer's
      Point of View.

PMID- 29840526
TI  - National Military Training.

PMID- 29840529
TI  - The Non-Panel Movement.

PMID- 29840527
TI  - Sir Almroth Wright on Woman Suffrage.

PMID- 29840528
TI  - Hospital and Institutional News.

PMID- 29840530
TI  - The Present State of Panel Medical Practice.

PMID- 29840531
TI  - The Threatened Strike of Asylum Nurses.

PMID- 29840532
TI  - Effect of Insurance Legislation on National Character in Germany.

PMID- 29840533
TI  - The National Medical Union Conference.

PMID- 29840534
TI  - The Clinical Laboratory: Alimentary Diseases.

PMID- 29840535
TI  - The Examination of "Leavers".

PMID- 29840536
TI  - The Structure of the Red Blood Corpuscle.

PMID- 29840538
TI  - Appointments in the Tuberculosis Service: Allegations of Corruption.

PMID- 29840537
TI  - The International Congress: Recent Surgical Developments.

PMID- 29840540
TI  - Grave Position at St. George's Hospital: The Causes of the Present Deadlock.
      Cease Personal Intrigues. Make the Hospital's Interests Paramount.

PMID- 29840539
TI  - Buildings Contemplated.

PMID- 29840542
TI  - Panel Work in Theory and Practice.

PMID- 29840541
TI  - British Workers in Foreign Countries: Hospital Life in Kashmir.

PMID- 29840544
TI  - Ionic Treatment of Dental Sepsis: The Prevalence and Prevention of the Disease.

PMID- 29840543
TI  - Hospital and Institutional News.

PMID- 29840545
TI  - The Investment of Funds.

PMID- 29840546
TI  - The London Ambulance Question: Its History and Present Position.

PMID- 29840547
TI  - State Hospitals: Why English Men and Women Can Never Suffer Them.

PMID- 29840548
TI  - The National Medical Union.

PMID- 29840549
TI  - Insured Patients.

PMID- 29840550
TI  - The New Poor-Law Orders.

PMID- 29840551
TI  - The Evolution of the Isolation Hospital.

PMID- 29840552
TI  - Reports on Hospitals of the United Kingdom: Report on West Norfolk and Lynn
      Hospital, King's Lynn.

PMID- 29840553
TI  - Effects of Fog in Institutions.

PMID- 29840554
TI  - Patients and Their Beauty Sleep.

PMID- 29840555
TI  - Personalia.

PMID- 29840556
TI  - The New Poor-Law Orders: Their Substance and Effect on Infirmary Work.

PMID- 29840558
TI  - The Last Days for Entering Insurance on Special Terms.

PMID- 29840557
TI  - Registered Hospitals and Asylums.

PMID- 29840559
TI  - Statistical Tables of Recoveries: The Value of Recovery Rates.

PMID- 29840560
TI  - Hospital and Institutional News.

PMID- 29840561
TI  - The Work of the Darenth Industiral Colony, Dartford: Dr. A. Rotherham on his
      Patients' Productivity.

PMID- 29840562
TI  - Cooking and Catering in Mental Hospitals: The Cause and Cure of "Institutional
      Cooking".

PMID- 29840563
TI  - Mental Research and Government Grants: How Best to Assist Existing Laboratories.

PMID- 29840565
TI  - The Mental Deficiency Act, 1913: The General Scope of Its Provisions.

PMID- 29840564
TI  - The Lord Mayor and Hospital Saturday.

PMID- 29840566
TI  - Four Practical Aspects of the Mental Deficiency Act, 1913.

PMID- 29840567
TI  - The Threatened Strike of Asylum Nurses: A Blow to their Prestige and Position in
      the Nursing World.

PMID- 29840568
TI  - The Feeble-Minded as Producers: Their Permanent Care in Industrial and Farm
      Colonies.

PMID- 29840569
TI  - Trade Unionism in Mental Hospitals: The Organisation of Asylum Workers.

PMID- 29840570
TI  - Mental Hospitals: Past and Present.

PMID- 29840571
TI  - The Sterilsation of the Unfit.

PMID- 29840572
TI  - The Gas Exhibition. I.-Model Laundry, Cooking Stoves, and Hospital Ranges.

PMID- 29840573
TI  - The Founder of the Red Cross Association.

PMID- 29840574
TI  - Eminent Chairman Series: II. Sir Edward Wood.

PMID- 29840575
TI  - News and Events of the Week.

PMID- 29840576
TI  - New Appliances and Things Medical.

PMID- 29840577
TI  - The Maxims of John Arderne, Master Surgeon.

PMID- 29840578
TI  - Workmen's Compensation Cases.

PMID- 29840579
TI  - Bilharziosis in Girls and Women.

PMID- 29840580
TI  - The Plague.

PMID- 29840581
TI  - Institutional Treatment of Tuberculosis.

PMID- 29840582
TI  - The Plague in Suffolk.

PMID- 29840583
TI  - Institutional Notes and News.

PMID- 29840584
TI  - The Late Prince Francis of Teck and the Middlesex Hospital.

PMID- 29840585
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29840586
TI  - The Week's Work.

PMID- 29840587
TI  - Annotations.

PMID- 29840588
TI  - Medical Opinion and Movement.

PMID- 29840589
TI  - The Hospital World.

PMID- 29840591
TI  - Chronic Gonorrhoea in the Female.

PMID- 29840590
TI  - The Girdle-Test (l'Epreuve de la Sangle).

PMID- 29840593
TI  - Winter Fads.

PMID- 29840592
TI  - Hope Hospital, Salford.

PMID- 29840594
TI  - Annotations.

PMID- 29840595
TI  - Some Points in the Choice of a Car.

PMID- 29840596
TI  - News and Events of the Week.

PMID- 29840597
TI  - Some Cases of Diabetes.

PMID- 29840598
TI  - The Hospital World.

PMID- 29840599
TI  - Reports on the Hospitals of the United Kingdom: LV. Essex County Hospital,
      Colchester.

PMID- 29840600
TI  - The Becket Hospital, Barnsley.

PMID- 29840601
TI  - Institutional Notes and News.

PMID- 29840602
TI  - The After-Care and Employment of Consumptives.

PMID- 29840603
TI  - Medical Opinion and Movement.

PMID- 29840604
TI  - The Week's Work.

PMID- 29840605
TI  - Private Rooms in Fever Hospitals.

PMID- 29840606
TI  - A Bad Beginning.

PMID- 29840607
TI  - The Detection of Blood Pigments in the Faeces.

PMID- 29840608
TI  - Acute Primary Pyelitis-Coli Bacilluria-in Children.

PMID- 29840610
TI  - The Tuberculin Test of Cattle as a Guarantee of Tubercle Free Milk.

PMID- 29840609
TI  - Parliament and Publications.

PMID- 29840612
TI  - Sunday Observance.

PMID- 29840611
TI  - Ambulance Arrangements for Hospitals.

PMID- 29840614
TI  - Pain in Some Foot Cases-III.

PMID- 29840613
TI  - Public Grants for Voluntary Hospitals.

PMID- 29840616
TI  - News and Events of the Week.

PMID- 29840615
TI  - Some Cases of Diabetes.

PMID- 29840618
TI  - Environment and Operation.

PMID- 29840617
TI  - Annotations.

PMID- 29840620
TI  - The American Hospital Association.

PMID- 29840619
TI  - Medical Opinion and Movement.

PMID- 29840622
TI  - The Hospital World.

PMID- 29840621
TI  - Charing Cross Hospital.

PMID- 29840623
TI  - Carbon Dioxide Snow.

PMID- 29840624
TI  - Some Points in the Choice of a Car-II.

PMID- 29840626
TI  - The Week's Work.

PMID- 29840625
TI  - The Value of Acetyl-Salicylic Acid in Certain Affections of the Eye.

PMID- 29840627
TI  - An Appeal for the Queen's.

PMID- 29840628
TI  - Institutional Notes and News.

PMID- 29840630
TI  - Urbs in Rure.

PMID- 29840629
TI  - Parliament and Publications.

PMID- 29840631
TI  - Infective Endocarditis Due to an Organism Not Hitherto Described.

PMID- 29840632
TI  - The Centre of Christmas Blessedness.

PMID- 29840633
TI  - Why This World Is like a Hospital.

PMID- 29840634
TI  - The League of Mercy: Annual Meeting at St. James's Palace: Prince Alexander of
      Teck's Address. The Results in 1913. How to Raise L50,000. The Triumph of the
      Voluntary System.

PMID- 29840635
TI  - The Meeting of Practitioners at Hammersmith: The Coming Crisis of 1915. Need for
      a Safe Fighting Fund. The Position of Medical M.P.s. The Marquis of Zetland v.
      the B.M.A. What Strength Has the Guild?

PMID- 29840637
TI  - My Impression of the Hospital: The Unaided Composition of a Patient Aged Eleven.

PMID- 29840636
TI  - National Medical Union Notes.

PMID- 29840639
TI  - Hospital and Institutional News.

PMID- 29840638
TI  - The Business of Charity: Remarkable Examples.

PMID- 29840640
TI  - The Elimination of the Middle Classes.

PMID- 29840642
TI  - What It Has Come to in Wales.

PMID- 29840641
TI  - The Hammersmith Meeting: An Impracticable Programme.

PMID- 29840643
TI  - Special Court Negatives the Proposed Changes: Text of the Amendment. Criticism
      and Interruptions. The Questions of Amalgamation and Site. An Independent
      Committee to Select a Site.

PMID- 29840644
TI  - The Metropolitan Hospital Sunday Fund: The Discussion at the Annual Meeting. A
      Serious Decrease in Income. Don't Grow Weary but Work for the Hospitals.

PMID- 29840645
TI  - The Campaign against Syphilis: An Anticipation of the Royal Commission's Report.

PMID- 29840646
TI  - The National Medical Union (Official).

PMID- 29840647
TI  - Reports on Hospitals of the United Kingdom: The Royal Surrey County Hospital,
      Guildford.

PMID- 29840648
TI  - The Liverpool Psycho-Therapeutic Institution.

PMID- 29840649
TI  - Workpeople's Contributions to Hospitals: Threatened with Legislative Destruction.

PMID- 29840650
TI  - Automatic Telephones for Institutions: The Composite Installation at New
      "King's".

PMID- 29840651
TI  - Polylactol.

PMID- 29840653
TI  - The Mental Hospital Service: Action by the Medical Officers.

PMID- 29840652
TI  - The Central Poor-Law Conference: Boards of Guardians and the Insurance Act.

PMID- 29840654
TI  - Benefits for Exempt Persons.

PMID- 29840655
TI  - The Origin and Evolution of the 18th Century Hospital Movement.

PMID- 29840656
TI  - Buildings Contemplated.

PMID- 29840657
TI  - Another Light on the Milk Problem: The Keeping Properties of Condensed Milks.

PMID- 29840658
TI  - Hospital and Institutional News.

PMID- 29840659
TI  - Race Improvement.

PMID- 29840660
TI  - Poor-Law Guardians and the Feeble-Minded.

PMID- 29840661
TI  - Treatment of Sciatica.

PMID- 29840663
TI  - Fellow-Workers and Their Doings.

PMID- 29840662
TI  - The Surgery of Malignant Disease.

PMID- 29840664
TI  - Research and Remedies.

PMID- 29840665
TI  - British Hospital Progress-1887-1913.

PMID- 29840666
TI  - Further Light on Irish Problems.

PMID- 29840667
TI  - A Review of Mr. Burns' Administration.

PMID- 29840668
TI  - Buildings Contemplated.

PMID- 29840669
TI  - The Tragedy and Comedy of the Act.

PMID- 29840670
TI  - The Position of Employed Contributors Now Entering Insurance.

PMID- 29840671
TI  - St. George's Hospital: The Special Court of Governors.

PMID- 29840672
TI  - The National Medical Union.

PMID- 29840673
TI  - The Insurance Acts and the Hospitals.

PMID- 29840674
TI  - The Open Basement.

PMID- 29840676
TI  - Mental Hospital Magazines: The Existing Product and a Gap to Be Filled.

PMID- 29840675
TI  - Pure Milk or Raw Milk? A Sidelight on the Milk Problem.

PMID- 29840677
TI  - Cardiology-Abderhalden's Test-Leukaemia-Sciatica.

PMID- 29840678
TI  - Hospital and Institutional News.

PMID- 29840679
TI  - Fellow-Workers and Their Doings.

PMID- 29840680
TI  - Reports on Hospitals of the United Kingdom: The St. Albans and Mid-Herts
      Hospital. Harrow Cottage Hospital.

PMID- 29840681
TI  - The Cardiff Medical School.

PMID- 29840682
TI  - Guardians and the Mental Deficiency Act.

PMID- 29840683
TI  - Post-Mortem Examinations.

PMID- 29840684
TI  - Institutional Needs.

PMID- 29840685
TI  - Staff Changes at Claybury.

PMID- 29840686
TI  - The Artificial Pneumothorax Operation.

PMID- 29840687
TI  - Flat Foot in School Children.

PMID- 29840688
TI  - National Medical Union.

PMID- 29840689
TI  - South Shields Guardians Withdraw Their Resolution.

PMID- 29840690
TI  - State Endowment of Unqualified Practice.

PMID- 29840691
TI  - Public Pharmacists' Association.

PMID- 29840692
TI  - Put St. George's Hospital First: The Past, the Present, and the Future.

PMID- 29840694
TI  - New Units at the Royal Infirmary, Sheffield.

PMID- 29840693
TI  - North Staffordshire Infirmary.

PMID- 29840695
TI  - Artificial Pneumothorax-Treatment of Aneurysm-Diathermy.

PMID- 29840696
TI  - Treatment in Mental Hospitals.

PMID- 29840698
TI  - The Convoy Corps in the Balkans.

PMID- 29840697
TI  - Reports on Hospitals of the United Kingdom: Bedford County Hospital.

PMID- 29840699
TI  - Doctor's Wills.

PMID- 29840700
TI  - The New Regulations as to Arrears of Contributions.

PMID- 29840701
TI  - Hospital Staff Appointments.

PMID- 29840702
TI  - A Warning to Non-Panel Men.

PMID- 29840703
TI  - Fellow-Workers and Their Doings.

PMID- 29840705
TI  - The Health Temples of Ancient Greece.

PMID- 29840704
TI  - Instruction in Psycho Therapy.

PMID- 29840707
TI  - The National Medical Union.

PMID- 29840706
TI  - Some Impressions of Continental Hospitals.

PMID- 29840709
TI  - St. George's Hospital.

PMID- 29840708
TI  - Hospital and Institutional News.

PMID- 29840710
TI  - Modern Methods of Transplantation.

PMID- 29840711
TI  - The National Medical Union's Latest Undertaking.

PMID- 29840712
TI  - More Panel Incidents at Dundee and Wisbech.

PMID- 29840713
TI  - The Editor's Letter-Box.

PMID- 29840714
TI  - Mr. J. F. Peart, F.R.C.S.I., on the Clinic Movement.

PMID- 29840715
TI  - A Dental Surgery in a Factory.

PMID- 29840716
TI  - The Camberwell Infirmary Case: Dr. W. J. C. Keats Awarded Damages for Libel.

PMID- 29840717
TI  - Sir George Newman's Report: The Year's Work in School Medical Inspection.

PMID- 29840719
TI  - Round the World.

PMID- 29840718
TI  - Dr. Midelton on Treatment by Continuous Counter-Irritation.

PMID- 29840721
TI  - Patients and Their "Beauty Sleep".

PMID- 29840720
TI  - Reports on Hospitals of the United Kingdom: Addenbrooke's Hospital, Cambridge.

PMID- 29840722
TI  - Examination Questions for Red Cross Students.

PMID- 29840723
TI  - The Origin and Evolution of the 18th Century Hospital Movement.

PMID- 29840724
TI  - The Hospitals and the Coal-Porters' Strike.

PMID- 29840725
TI  - Research and Remedies.

PMID- 29840726
TI  - A Pocketful of Reminiscences.

PMID- 29840727
TI  - Rate-Aided Clinical Pathology.

PMID- 29840728
TI  - Article 10 of the Poor-Law Orders.

PMID- 29840730
TI  - The Women's Hospital for Children, Harrow Road: An Institution Attempting Too
      Much.

PMID- 29840729
TI  - Hospital and Institutional News.

PMID- 29840731
TI  - London Staff Appointments.

PMID- 29840732
TI  - The Statistical Report of King Edward's Hospital Fund. IV.

PMID- 29840733
TI  - The Need for Specialism.

PMID- 29840734
TI  - A Test Case at Torquay.

PMID- 29840736
TI  - The Organisation of the Profession in Ireland.

PMID- 29840735
TI  - A German School of Recovery: The Example of the Mannheim Municipality.

PMID- 29840737
TI  - Sanatoria Treatment and the Poor Law.

PMID- 29840738
TI  - The Bradford Royal Infirmary Project.

PMID- 29840739
TI  - The Origin and Evolution of the 18th Century Hospital Movement.

PMID- 29840740
TI  - Mr. George's Panel Statistics.

PMID- 29840741
TI  - National Medical Union.

PMID- 29840743
TI  - Welsh Sanatorium Construction and Equipment: A Discussion at the Sanitary
      Institute.

PMID- 29840742
TI  - The Altheat Stove.

PMID- 29840745
TI  - Fellow-Workers and Their Doings.

PMID- 29840744
TI  - South Shields Guardians and the Use of Alcohol.

PMID- 29840746
TI  - Hospital and Institutional News.

PMID- 29840748
TI  - Penalties for Non-Payment of Arrears.

PMID- 29840747
TI  - The Control of the Invalid Children's Aid Association.

PMID- 29840749
TI  - Doctors' Wills.

PMID- 29840750
TI  - The Bradford Infirmary Project.

PMID- 29840751
TI  - Examination Questions for Red Cross Students.

PMID- 29840753
TI  - The Elimination of the Middle Class.

PMID- 29840752
TI  - Reports on Hospitals of the United Kingdom.

PMID- 29840754
TI  - Surgical Treatment of Diseases of Metabolism.

PMID- 29840755
TI  - The National Medical Union.

PMID- 29840756
TI  - The Poor-Law Institutions Order: The Duties of Workhouse Medical Officers.

PMID- 29840757
TI  - Hospital and Institutional News.

PMID- 29840758
TI  - The Best Side of a Man.

PMID- 29840759
TI  - Contributions from Approved Societies to Hospitals.

PMID- 29840761
TI  - London Medical Committee.

PMID- 29840760
TI  - National Medical Union, Manchester.

PMID- 29840762
TI  - Drug Markets at Home and Abroad.

PMID- 29840763
TI  - Dr. Keats on Infirmary Discipline.

PMID- 29840765
TI  - A Lesson in Self-Experimentation.

PMID- 29840764
TI  - Free Choice of Herbalist.

PMID- 29840766
TI  - Sir E. T. Cook's "Florence Nightingale": The Real Character of the Lady with the
      Lamp.

PMID- 29840768
TI  - South London Hospital.

PMID- 29840767
TI  - The Secrets of Economy in Institutional Housekeeping.

PMID- 29840769
TI  - Opening of the Marple Cripples' Home.

PMID- 29840770
TI  - Garden Cities for Consumptives : II. The Initial Organisation.

PMID- 29840772
TI  - Reports on Hospitals of the United Kingdom: Some Cottage Hospitals in Suffolk and
      Cambs.

PMID- 29840771
TI  - Modern Orthopaedy: Recent Advances and What They Mean.

PMID- 29840774
TI  - Staff Appointments at the Cardiff Medical School.

PMID- 29840773
TI  - The British Attitude Towards Vaccination Laws.

PMID- 29840776
TI  - The New Institution for Diseases of the Heart: A Tour of the New Buildings with
      the Secretary.

PMID- 29840775
TI  - Fellow-Workers and Their Doings.

PMID- 29840777
TI  - Where Is the Limit to Christmas Festivities.

PMID- 29840778
TI  - The New Poor-Law Orders: The Duties, and a Policy for Medical Officers.

PMID- 29840779
TI  - Westminster Hospital.

PMID- 29840780
TI  - Gastro-Radiography-Metallic Meals.

PMID- 29840781
TI  - Sir R. J. Collie on a State Medical Service.

PMID- 29840783
TI  - Hospital and Institutional News.

PMID- 29840782
TI  - Report on Some Cottage Hospitals in Norfolk and Suffolk: The Victoria Jubilee
      Hospital, Swaffham, Norfolk. Thetford Cottage Hospital. Mildenhall Cottage
      Hospital.

PMID- 29840784
TI  - Infantile Paralysis: Vast Strides in Recent Researches.

PMID- 29840785
TI  - The National Medical Union.

PMID- 29840786
TI  - The Grave Position at St. George's Hospital: How Matters Stand. Mr. West and St.
      George's Hospital.

PMID- 29840787
TI  - The Origin and Evolution of the 18th Century Hospital Movement.

PMID- 29840788
TI  - The Crisis at St. George's Hospital.

PMID- 29840790
TI  - Personalia.

PMID- 29840789
TI  - L'Affaire Lazarus-Barlow.

PMID- 29840792
TI  - The Statistical Report of King Edward's Hospital Fund-III.

PMID- 29840791
TI  - Alterations in Administration of Maternity Benefit.

PMID- 29840793
TI  - The Latest Developments of National Insurance.

PMID- 29840794
TI  - The Possibility of a Central Bureau.

PMID- 29840796
TI  - War against the Act.

PMID- 29840795
TI  - Marriage and Malthus.

PMID- 29840797
TI  - Reports on Hospitals of the United Kingdom: Essex County Hospital and the
      Braintree and Bocking Cottage Hospital.

PMID- 29840798
TI  - The Heel of Achilles in Hospital Diet.

PMID- 29840799
TI  - The Evolution of the Isolation Hospital.

PMID- 29840800
TI  - Progress under the Mental Deficiency Act.

PMID- 29840801
TI  - Children in Workhouses.

PMID- 29840802
TI  - Dr. W. J. C. Keats on Practical Points in Infirmary Work.

PMID- 29840804
TI  - The Special Examination of Mental Defectives.

PMID- 29840803
TI  - The Provision of a Punishment Book at Camberwell Infirmary.

PMID- 29840806
TI  - National Insurance. The Approved Societies and the Hospitals.

PMID- 29840805
TI  - The London Nerve Clinic.

PMID- 29840807
TI  - Electric Motors as Food Carriers.

PMID- 29840808
TI  - Common Errors in Diagnosis: Errors in Clinical Pathology.

PMID- 29840810
TI  - Collective Research for General Practitioners.

PMID- 29840809
TI  - British Workers in Foreign Countries: II. With the Wounded in Bulgaria.

PMID- 29840811
TI  - A Medical Woman to Her Sex.

PMID- 29840812
TI  - The Capitation Grant for Unallotted Persons.

PMID- 29840813
TI  - Hospital and Institutional News.

PMID- 29840814
TI  - Why an Orthopaedic Department Is Necessary.

PMID- 29840816
TI  - Garden Cities for Consumptives: A Plea for a National Scheme.

PMID- 29840815
TI  - Hospital Statistics. II.-A Suggested Remedy for the Present Chaos.

PMID- 29840817
TI  - A Woman's Experience in a London General Hospital.

PMID- 29840819
TI  - The Non-Panel Movement.

PMID- 29840818
TI  - Present State of Panel Practice.

PMID- 29840821
TI  - Personalia.

PMID- 29840822
TI  - Research and Remedies.

PMID- 29840820
TI  - Hospital Statistics.

PMID- 29840824
TI  - Hospital and Institutional News.

PMID- 29840823
TI  - Doctor's Wills.

PMID- 29840826
TI  - The Committee's Reply to Sir Cooper Perry's Report.

PMID- 29840825
TI  - The Control of Private Hospitals.

PMID- 29840827
TI  - The Value of a Man.

PMID- 29840828
TI  - The Effect of the Insurance Amendment Act on Hospital Finance.

PMID- 29840829
TI  - Reports on Hospitals of the United Kingdom: Chelmsford and Essex Hospital.

PMID- 29840830
TI  - Punishment in Poor-Law Infirmaries.

PMID- 29840831
TI  - The Examination of the Stomach Contents.

PMID- 29840832
TI  - Institutional Needs.

PMID- 29840833
TI  - Problems in Administrative Medicine: The Training of Institutional Porters and
      Male Attendants.

PMID- 29840834
TI  - Forcible Feeding and the Penal Reform League.

PMID- 29840835
TI  - The Non-Panel Movement.

PMID- 29840837
TI  - Hospital and Institutional News.

PMID- 29840836
TI  - The Alterations at Rochdale Infirmary.

PMID- 29840838
TI  - Practitioners and Nursing Homes: A Suggested Reform.

PMID- 29840839
TI  - Personalia.

PMID- 29840840
TI  - The Crisis at Camberwell Infirmary: The Committee's Report on the Medical Staff.

PMID- 29840841
TI  - An Experience in a Special Hospital.

PMID- 29840842
TI  - London County Council and Tuberculosis.

PMID- 29840843
TI  - The New Mental Board of Control.

PMID- 29840844
TI  - Public Pharmacists' and Dispensers' Association.

PMID- 29840845
TI  - With the Wounded in Bulgaria.

PMID- 29840846
TI  - Common Errors in Diagnosis: The Pitfalls of Panel and Private Practice.

PMID- 29840847
TI  - Buildings Contemplated and in Progress.

PMID- 29840848
TI  - The Treatment of "Dull" and "Defective" Children.

PMID- 29840849
TI  - A Peep behind the Scenes.

PMID- 29840850
TI  - Hospital and Institutional News.

PMID- 29840851
TI  - West Ham and Eastern General Hospital Dinner.

PMID- 29840852
TI  - Proposed New Regulations as to Medical Benefit.

PMID- 29840854
TI  - The Latest Hospital History.

PMID- 29840853
TI  - The Burden of Routine in Mental Hospitals.

PMID- 29840855
TI  - The Senghenydd Disaster.

PMID- 29840856
TI  - The Statistical Report of King Edward's Hospital Fund.

PMID- 29840857
TI  - Reports on Hospitals of the United Kingdom: Reports on Halstead and Cromer
      Cottage Hospitals.

PMID- 29840858
TI  - Garden Cities for Consumptives: Administrative Problems.

PMID- 29840859
TI  - The Non-Panel Movement.

PMID- 29840860
TI  - Vae Victis. Prophecy of Non-Panel Practitioners Fulfilled.

PMID- 29840861
TI  - Mission Hospitals of the Empire: Their Achievement and Position To-Day.

PMID- 29840862
TI  - A Patient's Appreciation.

PMID- 29840863
TI  - Personalia.

PMID- 29840864
TI  - Resident Medical Officers and Matrons.

PMID- 29840865
TI  - The Lay-Medical Dinner.

PMID- 29840866
TI  - Sir Felix Schuster on Hospital Finance.

PMID- 29840867
TI  - The Modern Orthopaedic Unit.

PMID- 29840868
TI  - The Worcester General Infirmary.

PMID- 29840869
TI  - Refusal of Benefits.

PMID- 29840870
TI  - Doctor's Will.

PMID- 29840871
TI  - A New Notion of Chloroma.

PMID- 29840872
TI  - Tuberculosis Dispensaries in Theory and Practice.

PMID- 29840873
TI  - The Modern Orthopaedic Unit: IV. The Out-Patient Division (continued).

PMID- 29840874
TI  - The Harley Institute.

PMID- 29840875
TI  - Some Likely Effects of Excessive Sickness Claims.

PMID- 29840876
TI  - Origin and Evolution of the 18th Century Hospital Movement.

PMID- 29840877
TI  - Confidential Reports and Their Abuses.

PMID- 29840878
TI  - Differing Systems of Patients' Contributions.

PMID- 29840879
TI  - Combination of Mental Hospital Staffs.

PMID- 29840880
TI  - St. George's Hospital.

PMID- 29840881
TI  - A Central Public Laboratory Clinic in Hospital and Private Practice.

PMID- 29840882
TI  - The Children's Hospital, Sunderland, Illustrated with Plans.

PMID- 29840884
TI  - Panel or Anti-Panel? Why Practitioners Must Make Their Choice!

PMID- 29840883
TI  - Reports on Hospitals of the United Kingdom: Great Yarmouth Hospital.

PMID- 29840885
TI  - Hospital and Institutional News.

PMID- 29840886
TI  - The Statistical Report of King Edward's Fund.

PMID- 29840887
TI  - The Panel and the Politician.

PMID- 29840888
TI  - Discontent in the Mental Hospital Service: Combination among Assistant Medical
      Officers.

PMID- 29840889
TI  - Fire at Winsley Sanatorium.

PMID- 29840890
TI  - Hospital Consultants and Panel Practice.

PMID- 29840891
TI  - What Will the Profession Gain by Combinations?

PMID- 29840892
TI  - An Epidemic and a Play at Manchester.

PMID- 29840893
TI  - Santa Claus in Great Ormond Street.

PMID- 29840894
TI  - Hospital and Institutional News.

PMID- 29840895
TI  - Institutional Needs.

PMID- 29840896
TI  - The Ansell Fortune.

PMID- 29840897
TI  - Children's Day at the Metropolitan.

PMID- 29840898
TI  - The Year's Work: "The Hospital's" Review of 1913.

PMID- 29840899
TI  - "Peter Pan" in a Private Mental Hospital.

PMID- 29840901
TI  - The National Medical Union.

PMID- 29840900
TI  - A Medical Retrospect of 1913: The Lessons of Experience.

PMID- 29840903
TI  - Another Sanatorium Christmas.

PMID- 29840902
TI  - The Clinic Movement: A New Medico-Psychological Institution.

PMID- 29840905
TI  - The Scheme for Raising Funds at Beckett Hospital, Barnsley.

PMID- 29840904
TI  - The Voluntary Hospitals' Outlook.

PMID- 29840907
TI  - Without Decorations at Grimsby.

PMID- 29840906
TI  - Board of Education and the Tuberculous Child.

PMID- 29840908
TI  - My First Christmas in Hospital.

PMID- 29840909
TI  - Reports on Hospitals of the United Kingdom: Report on the Norfolk and Norwich
      Hospital.

PMID- 29840910
TI  - Tango Decorations at Leeds.

PMID- 29840911
TI  - "A Christmas Dream" at Birmingham.

PMID- 29840912
TI  - A Ward Snowstorm at Bath.

PMID- 29840914
TI  - Novel Decorations at Wakefield Mental Hospital.

PMID- 29840913
TI  - Buildings Contemplated and in Progress.

PMID- 29840915
TI  - The First Christmas at Dagenham Sanatorium.

PMID- 29840916
TI  - Punch and Judy in the City Road.

PMID- 29840917
TI  - The Control of the Invalid Children's Aid Association.

PMID- 29840918
TI  - Important Conference of Non-Panel Practitioners.

PMID- 29840920
TI  - Personalia.

PMID- 29840919
TI  - Licensed Homes for Inebriates.

PMID- 29840921
TI  - What Is Wrong with St. George's Hospital?

PMID- 29840922
TI  - Buildings Contemplated.

PMID- 29840923
TI  - Worn-Out Hospital Officials.

PMID- 29840924
TI  - Reports on Hospitals of the United Kingdom: The East Suffolk and Ipswich
      Hospital.

PMID- 29840925
TI  - The Radcliffe Infirmary, Oxford: Its Re-Creation Completed.

PMID- 29840927
TI  - The London Ambulance Scheme.

PMID- 29840926
TI  - Common Errors in Diagnosis. Sprains and Fractures.

PMID- 29840929
TI  - The National Medical Union.

PMID- 29840928
TI  - Massage in England in 1913.

PMID- 29840930
TI  - London Healing Wells.

PMID- 29840931
TI  - Within the Hospitals: The London.

PMID- 29840933
TI  - Oxford and Modern Medicine.

PMID- 29840932
TI  - Hospital and Institutional News.

PMID- 29840934
TI  - National Insurance Act: The Prospect of the First Valuation.

PMID- 29840935
TI  - The Evolution of the Isolation Hospital.

PMID- 29840936
TI  - Fellow-Workers and Their Doings.

PMID- 29840937
TI  - Hospitals from the Patients' Point of View: Experiences in a Provincial Isolation
      Hospital.

PMID- 29840938
TI  - Questions Raised at the Private Visit.

PMID- 29840939
TI  - Sidelights on the Mineral Water Hospital, Bath.

PMID- 29840940
TI  - Public Pharmacists in Council.

PMID- 29840941
TI  - The National Medical Union (Official).

PMID- 29840942
TI  - Institutional Needs.

PMID- 29840943
TI  - A Legacy Question at Cardiff.

PMID- 29840944
TI  - Recent Progress in Genito-Urinary Surgery.

PMID- 29840946
TI  - The Soldiers' Daughters' Home, Hampstead: A Grave Scandal: Where Are the Health
      Authorities?

PMID- 29840945
TI  - Reports on Hospitals of the United Kingdom: The Northampton General Hospital.
      Letter from the Chairman.

PMID- 29840948
TI  - Hospital Economics.-V. The Statistical Report of King Edward's Hospital Fund.

PMID- 29840947
TI  - The Problem of Incipient Insanity.

PMID- 29840949
TI  - Ambulance Problems Solved and Unsolved.

PMID- 29840950
TI  - The Invention of Domiciliary Benefit.

PMID- 29840952
TI  - The Future of St. Katharine's Hospital.

PMID- 29840951
TI  - Working Men and Hospital Legacies.

PMID- 29840953
TI  - Hospital and Institutional News.

PMID- 29840954
TI  - Comparative Merits of Some Urinary Antiseptics: A Clue to the Vagaries of Urinary
      Sepsis.

PMID- 29840955
TI  - Doctors' Wills.

PMID- 29840956
TI  - A Novel King Edward Memorial.

PMID- 29840957
TI  - The Origin and Evolution of the 18th Century Hospital Movement.

PMID- 29840958
TI  - The State of the Tuberculosis Service.

PMID- 29840960
TI  - Children and Homoepathy.

PMID- 29840959
TI  - Institutional Needs.

PMID- 29840961
TI  - The National Medical Union (Official): The Resolutions Adopted Last Saturday. The
      Profession of Medicine.

PMID- 29840962
TI  - The Production of Braille Books.

PMID- 29840963
TI  - Fellow-Workers and Their Doings.

PMID- 29840964
TI  - Research and Remedies.

PMID- 29840965
TI  - Reports on Hospitals of the United Kingdom: Horsham Cottage Hospital. The Eliot
      Cottage Hospital, Hayward's Heath.

PMID- 29840966
TI  - Some Recent Novelties in Diagnostic Technique.

PMID- 29840967
TI  - Hospital Co-Operation in Hackney.

PMID- 29840968
TI  - Vacant Accommodation in London Workhouses.

PMID- 29840969
TI  - The Non-Panel Movement: Dr. Edwin Smith on Its Position and Prospects.

PMID- 29840970
TI  - Radium in the Treatment of Deafness.

PMID- 29840971
TI  - Electricity and Obesity: Treatment by Electrically Excited Exercise.

PMID- 29840972
TI  - Hospital and Institutional News.

PMID- 29840974
TI  - The Interim Report of the Fabian Society.

PMID- 29840973
TI  - Anti-Phthisis Activities in Berkshire.

PMID- 29840975
TI  - Co-Operative Buying for Hospitals: A Comparison of Methods in London and New
      York.

PMID- 29840976
TI  - Northampton General Hospital.

PMID- 29840977
TI  - Fellow-Workers and Their Doings.

PMID- 29840978
TI  - Anti-Phthisis Activities in Berkshire.

PMID- 29840979
TI  - Disease as an Accident.

PMID- 29840980
TI  - The Psycho-Therapeutics of Insanity.

PMID- 29840981
TI  - Research and Remedies.

PMID- 29840982
TI  - The County Council's New Scheme Explained.

PMID- 29840984
TI  - Miscellaneous Notes and Comments.

PMID- 29840983
TI  - Specialism and Hospital Committees.

PMID- 29840985
TI  - The National Medical Union (Official).

PMID- 29840986
TI  - Personalia.

PMID- 29840987
TI  - Doctors' Wills.

PMID- 29840988
TI  - The Clinical Application of Hormones.

PMID- 29840989
TI  - Institutional Needs.

PMID- 29840991
TI  - Reports on Hospitals of the United Kingdom: Cranleigh Village Cottage Hospital.

PMID- 29840990
TI  - Sanatoria and Convalescent Homes.

PMID- 29840993
TI  - Hospital and Institutional News.

PMID- 29840992
TI  - Buildings Contemplated.

PMID- 29840994
TI  - German Hospital Development: An Expert Continental Review.

PMID- 29840995
TI  - Dr. L. M. Guilding on the Effect of the Poor-Law Orders.

PMID- 29840997
TI  - Harley Institute.

PMID- 29840996
TI  - The Origin and Evolution of the 18th Century Hospital Movement.

PMID- 29840998
TI  - The Mortality from Phthisis: The Question of Personal Infection.

PMID- 29840999
TI  - A Winter in the Upper Engadine, 1885.

PMID- 29841000
TI  - Staff Changes at Camberwell Infirmary.

PMID- 29841001
TI  - Out-Patient Statistics and Cost: Supplementary Memorandum Issued by the Hospital
      Funds.

PMID- 29841002
TI  - The National Medical Union: Meeting of the Provisional Council.

PMID- 29841004
TI  - The New Empire Pay Hospital.

PMID- 29841003
TI  - Deficiencies and How They Will Be Made Good.

PMID- 29841006
TI  - King Edward's Hospital Fund.

PMID- 29841005
TI  - Ancoats Hospital and Amateur Actors.

PMID- 29841007
TI  - Trade or a Learned Profession?

PMID- 29841008
TI  - Hospital Almoners' Council.

PMID- 29841009
TI  - Hospital and Institutional News.

PMID- 29841010
TI  - The County Council and an Ambulance Service: The Report and Debate at Tuesday's
      Meeting.

PMID- 29841011
TI  - The National Medical Guild.

PMID- 29841012
TI  - Discontent in Mental Hospitals.

PMID- 29841014
TI  - Hospital Prophylaxis: The Prevention of Accidents.

PMID- 29841013
TI  - Dr. Walsh's Proposed Laboratory Clinic.

PMID- 29841015
TI  - Censorship to an Extreme.

PMID- 29841016
TI  - The Approved Societies and Their Medical Referees.

PMID- 29841017
TI  - A Successful Matinee.

PMID- 29841019
TI  - King Edward's Hospital Fund for London: Annual Meeting to Award Grants.

PMID- 29841018
TI  - Reports on Hospitals of the United Kingdom: Lowestoft Hospital.

PMID- 29841020
TI  - The Mental Hospital Service.

PMID- 29841021
TI  - Application and Dosage.

PMID- 29841022
TI  - Dangers and Reactions of Radium Treatment.

PMID- 29841023
TI  - Consultants and Press Announcements.

PMID- 29841025
TI  - Cost, and the Varieties of Radiations.

PMID- 29841024
TI  - Medico-Psychology.

PMID- 29841026
TI  - A Radium Policy for Poor-Law Unions.

PMID- 29841027
TI  - The First Essential to Successful Co-Operation.

PMID- 29841028
TI  - An Independent Organisation.

PMID- 29841030
TI  - The Therapeutic Applications of Radiations.

PMID- 29841029
TI  - Anniversary Meeting at Leicester Royal Infirmary.

PMID- 29841031
TI  - The Results of Radium Therapy.

PMID- 29841032
TI  - The Purchasing Power of a Sovereign.

PMID- 29841033
TI  - The First Step to Success.

PMID- 29841034
TI  - The Humbug of Closing Beds.

PMID- 29841035
TI  - A Free Service and Purchasing Agency.

PMID- 29841036
TI  - The National Medical Union (Official).

PMID- 29841037
TI  - Institutional Needs: A Provincial Centre for Hospital Furniture-"Hero" Liqueur
      Whisky-The "Eureka" Bandage-Invalid Lifters-"Regulin"-Institutional Waste
      Disposal.

PMID- 29841038
TI  - Sir Arthur Downes on Poor-Law Progress: New Theatre at Tynemouth Union.

PMID- 29841039
TI  - Fellow-Workers and Their Doings.

PMID- 29841040
TI  - A Bureau of Information.

PMID- 29841041
TI  - Hospital and Institutional News.

PMID- 29841042
TI  - Co-Operation.

PMID- 29841043
TI  - How Help May Be Given.

PMID- 29841044
TI  - Annotations.

PMID- 29841045
TI  - Mr. Gladstone and the Medical Profession.

PMID- 29841046
TI  - Around the Hospitals.

PMID- 29841047
TI  - The Attitude of Great Writers towards Disease: VI. Robert Burton.

PMID- 29841048
TI  - Thyroid Extract for Myxoedema. II.

PMID- 29841050
TI  - The Operative Treatment of Empyena and Abscess of the Lung.

PMID- 29841049
TI  - Everybody's Page.

PMID- 29841052
TI  - The New Hospital, Aden.

PMID- 29841051
TI  - Royal South Hants Infirmary, Southampton.

PMID- 29841053
TI  - Phenocoll Hydrochlorate.

PMID- 29841054
TI  - Medical History from the Earliest Times: XVIII.-The Methodic School.

PMID- 29841055
TI  - Lunacy in Scotland.

PMID- 29841056
TI  - Putting into Practice.

PMID- 29841057
TI  - Hospital Administration: III. Finance.

PMID- 29841058
TI  - The Hospital Nursing Supplement.

PMID- 29841059
TI  - Some Conditions Simulating Renal Calculus.

PMID- 29841060
TI  - The Multiplication of Metropolitan Hospitals.

PMID- 29841061
TI  - Notes and News.

PMID- 29841062
TI  - Notes and News.

PMID- 29841064
TI  - Asylums of the World. IV.-The Construction of Asylums.

PMID- 29841063
TI  - Street Collections.

PMID- 29841065
TI  - The Hospital Nursing Supplement.

PMID- 29841066
TI  - Editor's Letter Box.

PMID- 29841067
TI  - Everybody's Page.

PMID- 29841068
TI  - The Convalescent Home at Bonchurch.

PMID- 29841069
TI  - Faith Healing.

PMID- 29841070
TI  - Adonis Vernalis.

PMID- 29841071
TI  - The Royal Hospital for Incurables, Putney.

PMID- 29841072
TI  - Medical History from the Earliest Times: XIX.-Celsus and Ancient Surgery.

PMID- 29841073
TI  - The Crisis of the Voluntary Hospital.

PMID- 29841074
TI  - Paracentesis Pericardii.

PMID- 29841075
TI  - Conditions Simulating Renal Calculus II.

PMID- 29841077
TI  - Around the Hospitals.

PMID- 29841076
TI  - Proposed Central Board.

PMID- 29841079
TI  - The Attitude of Great Writers towards Disease: VII. Dante.

PMID- 29841078
TI  - Annotations.

PMID- 29841081
TI  - Annotations.

PMID- 29841080
TI  - Special Hospitals.

PMID- 29841083
TI  - The Cost of Out-Patients at Special Hospitals.

PMID- 29841082
TI  - An Account of the North Kensington Friendly Workers among the Poor.

PMID- 29841085
TI  - Hospitals Closed for Repairs.

PMID- 29841084
TI  - Tumours of the Bladder: Their Pathology and Diagnosis.

PMID- 29841087
TI  - On Some of the Relations between Chorea and Rheumatism.

PMID- 29841086
TI  - Everybody's Page.

PMID- 29841088
TI  - Quackery and Christianity.

PMID- 29841089
TI  - The Military (Alexander) Hospital. Warsaw.

PMID- 29841090
TI  - Notes and News.

PMID- 29841091
TI  - The History and Capabilities of Herbal Simples: Garlic and the Onion.

PMID- 29841092
TI  - First Lines of Defence.

PMID- 29841093
TI  - Facts about Cholera.

PMID- 29841095
TI  - Disease the Monitor.

PMID- 29841094
TI  - The Treatment of Lupus Vulgaris.

PMID- 29841097
TI  - The Treatment of Sleeplessness Complicating Other Diseases.

PMID- 29841096
TI  - The Hospital Nursing Supplement.

PMID- 29841098
TI  - Annotations.

PMID- 29841099
TI  - House Governor or Medical Superintendent?-II.

PMID- 29841100
TI  - Ladywell Sanatorium, Salford.

PMID- 29841101
TI  - Royal Hospital for Incurables.

PMID- 29841102
TI  - The Asylum Attendant of To-Day.

PMID- 29841104
TI  - Asylum or Hospital?

PMID- 29841103
TI  - The Attitude of Great Writers towards Disease: X. Keats and Shelley.

PMID- 29841106
TI  - The Choice of Calcium Salts.

PMID- 29841105
TI  - The Collapse of Matteism.

PMID- 29841108
TI  - The Hospital Nursing Supplement.

PMID- 29841107
TI  - Hospital Saturday Fund.

PMID- 29841110
TI  - The Medical Treatment of Perityphilitis and Appendicitis.

PMID- 29841109
TI  - Medical History from the Earliest Times: XXII.-Official Medicine in Ancient Rome.

PMID- 29841111
TI  - Hospital Administration: Finance.

PMID- 29841112
TI  - Notes and News.

PMID- 29841113
TI  - The Multiplication of Metropolitan Hospitals.

PMID- 29841114
TI  - The Present Treatment of Simple Pleurisy.

PMID- 29841115
TI  - Everybody's Page.

PMID- 29841116
TI  - The Attitude of Great Writers towards Disease: IX. Dickens-His Medical Science.

PMID- 29841117
TI  - The History and Capabilities of Herbal Simples: The Common Flag.

PMID- 29841118
TI  - Specialism and Individualism.

PMID- 29841119
TI  - Notes and News.

PMID- 29841121
TI  - Annotations.

PMID- 29841120
TI  - Medical History from the Earliest Times: XXI.-The Medical Profession in Rome.

PMID- 29841123
TI  - The Abortive Treatment of Coryza.

PMID- 29841122
TI  - New Drugs, Appliances, and Things Medical: Sanitas.

PMID- 29841124
TI  - Bacteriology and the Medical Art.

PMID- 29841125
TI  - Trephining for Epilepsy.

PMID- 29841126
TI  - Street Troughs and Glanders.

PMID- 29841127
TI  - The Hospital Nursing Supplement.

PMID- 29841128
TI  - House Governor or Medical Superintendent? I.

PMID- 29841130
TI  - Notes and News.

PMID- 29841129
TI  - The Nottingham General Hospital.

PMID- 29841132
TI  - The State and the Shop.

PMID- 29841131
TI  - Everybody's Page.

PMID- 29841133
TI  - Asaprol.

PMID- 29841134
TI  - Madmen and Their Friends.

PMID- 29841135
TI  - The Attitude of Great Writers towards Disease: XI. The Literature of Despair.

PMID- 29841136
TI  - An Account of the North Kensington Friendly Workers among the Poor.

PMID- 29841138
TI  - Phenocoll Hydrochlerate.

PMID- 29841137
TI  - The Service of Meals in Asylums.

PMID- 29841140
TI  - The Hospital Nursing Supplement.

PMID- 29841139
TI  - The Discussion on the Treatment of Spinal Abscess at the Nottingham Meeting of
      the British Medical Association.

PMID- 29841141
TI  - Annotations.

PMID- 29841142
TI  - Scarlet Fever.

PMID- 29841143
TI  - New Drugs, Appliances, and Things Medical: Diagram of the Mouth, Fauces and
      Larynx.

PMID- 29841144
TI  - The Manchester Crematorium.

PMID- 29841145
TI  - General Hospitals.

PMID- 29841146
TI  - House Governor or Medical Superintendent?-III.

PMID- 29841147
TI  - Hypnotism and Hysteria.

PMID- 29841148
TI  - Lifeboat Saturday.

PMID- 29841149
TI  - The British Medical Association.

PMID- 29841150
TI  - Spasmodic Torticollis: Treatment by Resection of Cervical Nerves.

PMID- 29841151
TI  - Annotations.

PMID- 29841153
TI  - Everybody's Page.

PMID- 29841152
TI  - Medical History from the Earliest Times: XX.-Galen.

PMID- 29841154
TI  - The Royal Hospital for Incurables, Putney.

PMID- 29841155
TI  - The Hospital Nursing Supplement.

PMID- 29841157
TI  - The Attitude of Great Writers towards Disease: VIII. Dickens.

PMID- 29841156
TI  - The Latest Criticism.

PMID- 29841158
TI  - Erysipelas.

PMID- 29841159
TI  - Metropolitan Hospital Sunday Fund.

PMID- 29841161
TI  - Notes and News.

PMID- 29841160
TI  - Finance.

PMID- 29841162
TI  - The Meaning of Pain.

PMID- 29841163
TI  - The Invalid Children's Aid Association.

PMID- 29841164
TI  - Around the Hospitals.

PMID- 29841165
TI  - Coronilla Varia.

PMID- 29841167
TI  - Forres Leanchoil Hospital.

PMID- 29841166
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29841168
TI  - Past and Present.

PMID- 29841169
TI  - Friends in Need.

PMID- 29841170
TI  - The Laundry.

PMID- 29841171
TI  - Notes and News.

PMID- 29841173
TI  - Diet in Enteric Fever.

PMID- 29841172
TI  - An Account of the North Kensington Friendly Workers among the Poor.

PMID- 29841175
TI  - Not out of Danger.

PMID- 29841174
TI  - The Brine Bath Treatment of Cholera.

PMID- 29841176
TI  - Treatment of Acute Pleuritis.

PMID- 29841177
TI  - Ephedra Vulgaris.

PMID- 29841178
TI  - Annotations.

PMID- 29841179
TI  - Pedants of Superlative Calibre.

PMID- 29841180
TI  - New South Wales Asylum.

PMID- 29841181
TI  - Football.

PMID- 29841183
TI  - The Hospital Nursing Supplement.

PMID- 29841182
TI  - Medical History from the Earliest Times: XXIII.-Roman Military Medicine.

PMID- 29841184
TI  - Women as Workers: I. Where Women Must Fail.

PMID- 29841185
TI  - An Account of the North Kensington Friendly Workers among the Poor.

PMID- 29841186
TI  - The Pleasantries of the Mob.

PMID- 29841188
TI  - The Hospital Nursing Supplement.

PMID- 29841187
TI  - Medical History from the Earliest Times: XXIV.-The Influence of Christianity on
      Medicine.

PMID- 29841190
TI  - Mr. William John Nixon.

PMID- 29841189
TI  - Cholera Precautions.

PMID- 29841192
TI  - The Treatment of Internal Haemorrhage.

PMID- 29841191
TI  - Notes and News.

PMID- 29841193
TI  - Women as Workers: II. Where Women Need Not Fail.

PMID- 29841194
TI  - Diabetes.

PMID- 29841195
TI  - Cholera Inoculation.

PMID- 29841196
TI  - Everybody's Page.

PMID- 29841198
TI  - Annotations.

PMID- 29841197
TI  - The Laundry.

PMID- 29841199
TI  - On Chronic Pharyngitis.

PMID- 29841201
TI  - Annotations.

PMID- 29841200
TI  - The Hospital Boom.

PMID- 29841202
TI  - Notes and News.

PMID- 29841203
TI  - Around the Hospitals.

PMID- 29841204
TI  - The Hospital Nursing Supplement.

PMID- 29841206
TI  - With Modern Eyes.

PMID- 29841205
TI  - The Sunlight Cure.

PMID- 29841207
TI  - Medical History from the Earliest Times: VI.-Hindoo Medicine.

PMID- 29841208
TI  - Practical Points.

PMID- 29841209
TI  - Poisons and Poisoners: Strychnia-Dr. Palmer.

PMID- 29841210
TI  - Amoebic Dysentery.

PMID- 29841211
TI  - In Reversion.

PMID- 29841212
TI  - Royal Berkshire Hospital, Reading.

PMID- 29841213
TI  - The Question of Surgical Interference in Cases of Perityphlitis.

PMID- 29841214
TI  - The Royal South London Ophthalmic Hospital.

PMID- 29841215
TI  - The Hospital Nursing Supplement.

PMID- 29841216
TI  - Asylum for the Insane, Waterbury, Vermont.

PMID- 29841217
TI  - Laminectomy for Compression Paraplegia Due to Spinal Caries.

PMID- 29841218
TI  - New Drugs. Appliances, and Things Medical.

PMID- 29841219
TI  - Injuries to the Fingers.

PMID- 29841221
TI  - Annotations.

PMID- 29841220
TI  - The Hospital Problem.

PMID- 29841223
TI  - Home Libraries in Boston.

PMID- 29841222
TI  - The Chronic Indigence of Our Hospitals, with Some Suggestions for Its Remedy:
      III.-The Material Deficit.

PMID- 29841225
TI  - Medical History from the Earliest Times: IV.-Medicine in Ancient Egypt.

PMID- 29841224
TI  - Notes and News.

PMID- 29841226
TI  - Saturday Fund Statistics.

PMID- 29841227
TI  - Impatient Science.

PMID- 29841228
TI  - Hospital in Hong Kong.

PMID- 29841229
TI  - Epiphora.

PMID- 29841230
TI  - Everybody's Page.

PMID- 29841231
TI  - Notes and News.

PMID- 29841232
TI  - The Hospital Nursing Supplement.

PMID- 29841233
TI  - Unmarried Hampstead: Much Married Whitechapel.

PMID- 29841235
TI  - Gloucester Asylum.

PMID- 29841234
TI  - Practical Points.

PMID- 29841236
TI  - More Room, or Better Room?

PMID- 29841237
TI  - New Drugs. Appliances, and Things Medical: Sedox Absorbent Dressings.

PMID- 29841238
TI  - Medical History from the Earliest Times: III.-Medicine as Practised by
      Uncivilised Man.

PMID- 29841239
TI  - The Story of the Insane from Year to Year.

PMID- 29841240
TI  - The Diagnosis, Localisation, and Surgical Treatment of Tumours Pressing on the
      Spinal Cord.

PMID- 29841241
TI  - Annotations.

PMID- 29841242
TI  - The New Hall for Operations at the Large Municipal Hospital, Copenhagen.

PMID- 29841244
TI  - Everybody's Page.

PMID- 29841243
TI  - The Chronic Indigence of Our Hospitals, with Some Suggestions for Its Remedy: II.
      Difficulties of Hospital Finance.

PMID- 29841245
TI  - Rumination in Human Beings.

PMID- 29841246
TI  - Mud and Muddle.

PMID- 29841247
TI  - The Abuse of Mercury in the Treatment of Eye Diseases.

PMID- 29841248
TI  - The Alice Memorial Hospital, Hong Kong.

PMID- 29841249
TI  - Drunkenness and Crime.

PMID- 29841250
TI  - Notes and News.

PMID- 29841251
TI  - The Student in Vienna.

PMID- 29841252
TI  - The Royal Infirmary and Medical School, Newcastle-On-Tyne.

PMID- 29841253
TI  - The Hospital Nursing Supplement.

PMID- 29841254
TI  - The Medicine of the Future.

PMID- 29841255
TI  - Around the Hospitals.

PMID- 29841256
TI  - Annotations.

PMID- 29841258
TI  - To First Year's Men.

PMID- 29841257
TI  - An Account of the North Kensington Friendly Workers among the Poor.

PMID- 29841260
TI  - On Resection of Intestine.

PMID- 29841259
TI  - Everybody's Page.

PMID- 29841262
TI  - Medical Schools and Degrees.

PMID- 29841261
TI  - Mr. Nixon's Resignation at the London Hospital.

PMID- 29841264
TI  - The Fleming Memorial Hospital for Sick Children, Newcastle-On-Tyne.

PMID- 29841263
TI  - Metropolitan and Provincial Medical Schools: Their Cost and Course.

PMID- 29841265
TI  - List of Hospitals and Medical Schools.

PMID- 29841266
TI  - A New Post-Mortem Table.

PMID- 29841267
TI  - Around the Hospitals.

PMID- 29841268
TI  - The Chronic Indigence of Our Hospitals, with Some Suggestions for Its Remedy: IV.
      What Might Be.

PMID- 29841269
TI  - Annotations.

PMID- 29841271
TI  - Canon Newbolt on Suffering and Good-Will.

PMID- 29841270
TI  - Pensions without Penalties.

PMID- 29841272
TI  - On the Feeding of Infants.

PMID- 29841273
TI  - New York Children's Aid Society.

PMID- 29841275
TI  - The Secret of Youth.

PMID- 29841274
TI  - Medical History from the Earliest Times: V.-Medicine in Ancient Egypt.

PMID- 29841276
TI  - Notes and News.

PMID- 29841277
TI  - The Hospital Nursing Supplement.

PMID- 29841278
TI  - Everybody's Page.

PMID- 29841279
TI  - On the Treatment of Nasal Polypi.

PMID- 29841281
TI  - Mucocele.

PMID- 29841280
TI  - The Attitude of the Great Writers towards Disease: I. Sir Walter Scott.

PMID- 29841282
TI  - Annotations.

PMID- 29841283
TI  - Oxygen at Oxford.

PMID- 29841284
TI  - Notes and News.

PMID- 29841285
TI  - The Chronic Indigence of Our Hospitals, with Some Suggestions for Its Remedy: I.
      A Bird's Eye View.

PMID- 29841286
TI  - Everybody's Page.

PMID- 29841287
TI  - New Drugs. Appliances, and Things Medical: Improvement in Syphons.

PMID- 29841289
TI  - The Long-Suffering Middle-Class.

PMID- 29841288
TI  - The Hospital Nursing Supplement.

PMID- 29841291
TI  - The Mary Hitchcock Memorial Hospital, Hanover, N.H., U.S.A.

PMID- 29841290
TI  - The Story of the Insane from Year to Year.

PMID- 29841293
TI  - The Symptoms of Surgical Affections of the Kidneys.

PMID- 29841292
TI  - A Model Prison.

PMID- 29841294
TI  - Medical History from the Earliest Times: II. Medicine in Prehistoric Times.

PMID- 29841295
TI  - Intubation in Laryngeal Tuberculosis.

PMID- 29841296
TI  - Phagocytosis.

PMID- 29841297
TI  - The Hospitals and Hospital Saturday.

PMID- 29841298
TI  - Everybody's Page.

PMID- 29841299
TI  - Notes and News.

PMID- 29841300
TI  - Anarchism in Physic.

PMID- 29841301
TI  - The Radcliffe Infirmary.

PMID- 29841303
TI  - An Ideal Scheme of Co-Operation.

PMID- 29841302
TI  - Medical History from the Earliest Times: VII.-Chaldean and Persian Medicine.

PMID- 29841304
TI  - A Model Slop Sink.

PMID- 29841305
TI  - New Drugs, Appliances, and Things Medical: A Noiseless Pail.

PMID- 29841306
TI  - Chronic Ulcer of the Legs.

PMID- 29841307
TI  - The Story of the Insane from Year to Year.

PMID- 29841308
TI  - The Hospital Nursing Supplement.

PMID- 29841309
TI  - Wages versus Comfort: A Scottish Sketch.

PMID- 29841310
TI  - The Treatment of Nocturnal Incontinence.

PMID- 29841311
TI  - Inebriates.

PMID- 29841313
TI  - Annotations.

PMID- 29841312
TI  - Around the Hospitals.

PMID- 29841315
TI  - Annotations.

PMID- 29841314
TI  - Close Times.

PMID- 29841316
TI  - The Orphan Working School.

PMID- 29841317
TI  - Notes and News.

PMID- 29841318
TI  - Alteration at Rotherhithe Infirmary.

PMID- 29841319
TI  - Salicylic Acid in the Treatment of Acute Rheumatism.

PMID- 29841320
TI  - Medical History from the Earliest Times: IX.-The Philosophers-Democedes-The
      AEsclepiadae.

PMID- 29841321
TI  - Royal National Hospital for Consumption, Ventnor.

PMID- 29841322
TI  - Around the Hospitals.

PMID- 29841323
TI  - Elongated Uvula.

PMID- 29841324
TI  - The Hospital Nursing Supplement.

PMID- 29841325
TI  - King's College Hospital.

PMID- 29841326
TI  - Everybody's Page.

PMID- 29841327
TI  - The Eight Hours Day.

PMID- 29841328
TI  - Treatment of Trachoma.

PMID- 29841329
TI  - The Attitude of Great Writers towards Disease: II. Shakespeare.

PMID- 29841330
TI  - Secret Remedies.

PMID- 29841332
TI  - Notes and News.

PMID- 29841331
TI  - Must.

PMID- 29841333
TI  - Anaesthetics.

PMID- 29841334
TI  - Medical History from the Earliest Times: XII.-The Successors of Hippocrates-The
      Dogmatic School.

PMID- 29841336
TI  - The Hospital Nursing Supplement.

PMID- 29841335
TI  - Faith and Science at the Hospitals.

PMID- 29841338
TI  - Poisons and Poisoners: The Marquise De Brinvilliers.

PMID- 29841337
TI  - Infectious Diseases in Private Houses.

PMID- 29841339
TI  - Everybody's Page.

PMID- 29841340
TI  - The Work of the Hospitals: Hospital Accommodation for Bread-Winners. II.-Hospital
      Accomodation for Women. III.-What the Hospitals Do for the Middle Classes. IV.
      With the Children. V.-The Chronic Diseases of Children; Incurable Homes; and
      Other Supplementary Work.

PMID- 29841342
TI  - Annotations.

PMID- 29841341
TI  - Annotations.

PMID- 29841343
TI  - Some American Hospitals.

PMID- 29841344
TI  - Sympathetic Ophthalmitis.

PMID- 29841345
TI  - Air and Water.

PMID- 29841346
TI  - The Hospital Nursing Supplement.

PMID- 29841347
TI  - Bronchitis or Tracheotomy Kettle.

PMID- 29841348
TI  - The Attitude of Great Writers towards Disease: III. French Satirists and the
      Doctors.

PMID- 29841350
TI  - National Hospital for the Paralysed and Epileptic.

PMID- 29841349
TI  - Suffering London.

PMID- 29841351
TI  - City of London Hospital for Diseases of the Chest.

PMID- 29841352
TI  - Suffering London: The "Globe's" Parable.

PMID- 29841354
TI  - Bryonia.

PMID- 29841353
TI  - The Story of the Insane from Year to Year.

PMID- 29841356
TI  - Vicarious Benevolence.

PMID- 29841355
TI  - Drainage of the Ventricles in Meningitis.

PMID- 29841358
TI  - North London Hospital for Consumption.

PMID- 29841357
TI  - The Treatment of Cough in Phthisis.

PMID- 29841359
TI  - Bucket Fire Extinguisher.

PMID- 29841360
TI  - Great Ormond Street Children's Hospital.

PMID- 29841361
TI  - Around the Hospitals.

PMID- 29841363
TI  - Notes and News.

PMID- 29841362
TI  - Medical History from the Earliest Times: XI.-The Schools of Cos and Cnidus.

PMID- 29841364
TI  - Notes and News.

PMID- 29841365
TI  - The Story of the Insane from Year to Year.

PMID- 29841366
TI  - New Drugs, Appliances, and Things Medical: Jelly Carnis (Caffyn).

PMID- 29841367
TI  - The Appeal of the Insane to Science.

PMID- 29841369
TI  - Impotent Oxford and Its Melancholy Hospital.

PMID- 29841368
TI  - A New Departure.

PMID- 29841371
TI  - Carrying, Commode, and Bath Chairs.

PMID- 29841370
TI  - The Causation and Pathology of Rickets.

PMID- 29841373
TI  - Around the Hospitals.

PMID- 29841372
TI  - Post Pharyngeal Abscess.

PMID- 29841375
TI  - Practical Points.

PMID- 29841374
TI  - Annotations.

PMID- 29841377
TI  - The Hospital Nursing Supplement.

PMID- 29841376
TI  - Hyperaemia of the Conjunctiva - Simple Conjunctivitis.

PMID- 29841379
TI  - On the Special Requirements of Ophthalmic Hospitals.

PMID- 29841378
TI  - Excreta or Bed-Pan Cage.

PMID- 29841380
TI  - Everybody's Page.

PMID- 29841381
TI  - Juvenile Smokers.

PMID- 29841383
TI  - Medical History from the Earliest Times: VIII.-The Earliest Greek Medicine-Homer
      AEsculapius.

PMID- 29841382
TI  - A New Form of Hospital Slop Sink.

PMID- 29841384
TI  - Medical History from the Earliest Times: X.-Hippocrates.

PMID- 29841385
TI  - Wanted-Locality.

PMID- 29841386
TI  - Cinder-Bin and Sifter.

PMID- 29841387
TI  - Notes and News.

PMID- 29841389
TI  - Temporary Hospitals.

PMID- 29841388
TI  - Annotations.

PMID- 29841390
TI  - Bed Rests.

PMID- 29841391
TI  - New Drugs, Appliances, and Things Medical: Ingrowing Toe-Nails.

PMID- 29841393
TI  - The Clarence Memorial Wing at St. Mary's Hospital.

PMID- 29841392
TI  - Poor Man's Gout.

PMID- 29841395
TI  - Everybody's Page.

PMID- 29841394
TI  - Around the Hospitals.

PMID- 29841397
TI  - Suffering London.

PMID- 29841396
TI  - The Hospital Nursing Supplement.

PMID- 29841399
TI  - Bed Table.

PMID- 29841398
TI  - Radcliffe Infirmary, Oxford.

PMID- 29841400
TI  - The Royal London Ophthalmic Hospital.

PMID- 29841401
TI  - Prisons at Home and Abroad.

PMID- 29841402
TI  - Colles's Fracture.

PMID- 29841403
TI  - Horse Civilisation in Shetland and Wales.

PMID- 29841404
TI  - Is Laminectomy Desirable in Traumatic Compression of the Cord?

PMID- 29841405
TI  - The Hospitals Association.

PMID- 29841407
TI  - A Centenary Collapse.

PMID- 29841406
TI  - Mr. Keir Hardie and the Miners.

PMID- 29841409
TI  - The Royal Portsmouth, Portsea, and Gosport Hospital.

PMID- 29841408
TI  - Medical History from the Earliest Times: XIV.-Heraclides and the Empiric School.

PMID- 29841411
TI  - Compulsory Vaccination.

PMID- 29841410
TI  - Is Vivisection Irreligious, Immoral, or Inhumane?

PMID- 29841412
TI  - Suffering London: Stirring Addresses by Sir Andrew Clark and Mr. A. Egmont Hake.

PMID- 29841414
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29841413
TI  - Annotations.

PMID- 29841416
TI  - Notes and News.

PMID- 29841417
TI  - Around the Hospitals.

PMID- 29841415
TI  - The Hospital Nursing Supplement.

PMID- 29841418
TI  - The Position of the Medical Examiner for Life Assurance.-II.

PMID- 29841419
TI  - A Central Council.

PMID- 29841420
TI  - Everybody's Page.

PMID- 29841422
TI  - Asylums of the World : II.-Treatment.

PMID- 29841421
TI  - Some of the Less Frequently Recognised Affections of Joints.

PMID- 29841423
TI  - The Royal Hants County Hospital, Winchester.

PMID- 29841424
TI  - Around the Hospitals.

PMID- 29841426
TI  - Practical Points.

PMID- 29841425
TI  - Medical History from the Earliest Times: XVI.-The Medical Profession in Ancient
      Greece.

PMID- 29841427
TI  - Bill Sykes's Son.

PMID- 29841428
TI  - Everybody's Page.

PMID- 29841430
TI  - Notes and News.

PMID- 29841429
TI  - New Drugs, Appliances, and Things Medical: Mellin's Food.

PMID- 29841432
TI  - The Ideals of Science.

PMID- 29841431
TI  - Special Hospitals.

PMID- 29841434
TI  - Some "Bloated Aristocrats" of Physic.

PMID- 29841433
TI  - On the Treatment of Cystic Goitre.

PMID- 29841435
TI  - The Death-Rate of Pneumonia.

PMID- 29841436
TI  - The Hospital Nursing Supplement.

PMID- 29841437
TI  - The Lords and the Nurses.

PMID- 29841438
TI  - Is Vivisection Immoral?

PMID- 29841440
TI  - Annotations.

PMID- 29841439
TI  - Hypermetropic Headaches.

PMID- 29841441
TI  - "Barraque" Wards.

PMID- 29841442
TI  - Hospital Administration: II. Admission of Patients.

PMID- 29841444
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29841443
TI  - Annotations.

PMID- 29841446
TI  - The Story of the Insane from Year to Year.

PMID- 29841445
TI  - Medical History from the Earliest Times: XIII.-The Alexandrine Anatomists.

PMID- 29841447
TI  - Around the Hospitals.

PMID- 29841448
TI  - Samaritans Ancient and Modern.

PMID- 29841449
TI  - Everybody's Page.

PMID- 29841450
TI  - The Position of the Medical Examiner in Life Assurance.-I.

PMID- 29841451
TI  - The Hospital Nursing Supplement.

PMID- 29841452
TI  - Notes and News.

PMID- 29841453
TI  - A Year's Work in the Hospitals and Medical Charities of London.

PMID- 29841454
TI  - The History and Capabilities of Herbal Simples: XXXIX.-The Fig.

PMID- 29841456
TI  - The Sincerity of Modern Medicine.

PMID- 29841455
TI  - A Central Council.

PMID- 29841457
TI  - Diagnosis in Stricture of the OEsophagus.

PMID- 29841458
TI  - The Attitude of Great Writers towards Disease: V. Lord Tennyson.

PMID- 29841459
TI  - Medical History from the Earliest Times: XVII.-Early Roman Medicine.

PMID- 29841460
TI  - Around the Hospitals.

PMID- 29841461
TI  - The Hospital Nursing Supplement.

PMID- 29841463
TI  - Society for the Study of Inebriety.

PMID- 29841462
TI  - Asylums of the World. III.-Administration and Nursing.

PMID- 29841464
TI  - Everybody's Page.

PMID- 29841465
TI  - Thyroid Extract for Myxoedema.

PMID- 29841467
TI  - Interstitial Keratuis.

PMID- 29841466
TI  - Notes and News.

PMID- 29841468
TI  - The Metropolitan Hospital.

PMID- 29841469
TI  - Annotations.

PMID- 29841471
TI  - Hospital Committees, Trained Nurses, and the Public.

PMID- 29841470
TI  - Employments for Women: IV. Lecturing for the County Councils.

PMID- 29841472
TI  - Addenbrooke's Hospital, Cambridge.

PMID- 29841473
TI  - Medical History from the Earliest Times: XV.-Military Medicine in Ancient Greece.

PMID- 29841474
TI  - The Other Cheek.

PMID- 29841475
TI  - Around the Hospitals.

PMID- 29841477
TI  - Organisation.

PMID- 29841476
TI  - The Position of the Medical Examiner for Life Assurance.-III.

PMID- 29841478
TI  - Notes and News.

PMID- 29841479
TI  - Gangrene.

PMID- 29841480
TI  - The Attitude of Great Writers towards Disease: IV. Jane Austen.

PMID- 29841481
TI  - Paddington Infirmary.

PMID- 29841483
TI  - The Report on Metropolitan Hospitals.

PMID- 29841482
TI  - Asylums of the World : I. History and Early Treatment.

PMID- 29841485
TI  - Victory.

PMID- 29841484
TI  - The Report of the Lords Committee.

PMID- 29841487
TI  - Everybody's Page.

PMID- 29841486
TI  - The Therapeutical Action of the Salts of Strontium.

PMID- 29841489
TI  - Annotations.

PMID- 29841488
TI  - The Hospital Nursing Supplement.

PMID- 29841490
TI  - The Modern Orthopaedic Unit.

PMID- 29841491
TI  - Raise Your Standard of Efficiency.

PMID- 29841492
TI  - The Local Government Board's Annual Report.

PMID- 29841493
TI  - Reports on Hospitals of the United Kingdom: Huntingdon County Hospital. Bury St.
      Edmund's Hospital.

PMID- 29841494
TI  - Hospitals and the Truck Act.

PMID- 29841496
TI  - Dental Treatment at Tuberculosis Dispensaries.

PMID- 29841495
TI  - The Alterations at Chichester Infirmary.

PMID- 29841497
TI  - The Decline in the Tuberculosis Death-Rate.

PMID- 29841498
TI  - The Trend of Research in Mental Hospitals.

PMID- 29841499
TI  - On Going out of Insurance.

PMID- 29841500
TI  - Hospital and Institutional News.

PMID- 29841501
TI  - A Point for Sanatoria Committees.

PMID- 29841503
TI  - Once More the Wrong Method.

PMID- 29841502
TI  - The National Medical Union.

PMID- 29841505
TI  - Inexpensive Mental Homes for the Middle Classes.

PMID- 29841504
TI  - Fellow-Workers and Their Doings.

PMID- 29841506
TI  - Hospitals and Vaccine Therapy.

PMID- 29841507
TI  - St. George's Hospital: A Settlement in Sight.

PMID- 29841508
TI  - A Winter in the Upper Engadine, 1885.

PMID- 29841509
TI  - Article 10 of the Poor-Law Orders.

PMID- 29841510
TI  - Reforms in County Council Mental Hospitals.

PMID- 29841511
TI  - Voluntary Hospitals and Paying Patients.

PMID- 29841512
TI  - What We Owe to Experiments on Animals: II. Pathology, Bacteriology, and
      Therapeutics (continued).

PMID- 29841513
TI  - On the Etiology of Carcinoma.

PMID- 29841514
TI  - The Royal Alexandra Hospital for Children, Rhyl.

PMID- 29841515
TI  - St. Bartholomew's Hospital.

PMID- 29841516
TI  - Glances at the Hospitals.

PMID- 29841517
TI  - Floor Covering for Hospitals.

PMID- 29841518
TI  - St. Bartholomew's Hospital.

PMID- 29841520
TI  - Annotations.

PMID- 29841519
TI  - The Value of Ureteral Catheterisation and Cryoscopy of the Urine.

PMID- 29841522
TI  - Permanent Military Hospitals.

PMID- 29841521
TI  - Nursing Section.

PMID- 29841524
TI  - The Treatment of Fractures from a Common-Sense Point of View: IX. Fractures in
      the Neighbourhood of the Elbow.

PMID- 29841523
TI  - The British Pharmaceutical Codex.

PMID- 29841525
TI  - The Electrolytic Destruction of Bacilli.

PMID- 29841526
TI  - The Administration of Anaesthetics.

PMID- 29841527
TI  - Psychasthenia: Its Evolution, Course, Diagnosis, and Treatment.

PMID- 29841528
TI  - To a Club Patient.

PMID- 29841529
TI  - The Hospital Saturday Fund.

PMID- 29841530
TI  - Prescriptions and Dispensing.

PMID- 29841531
TI  - The Problem of Rural Midwifery.

PMID- 29841532
TI  - Treatment of Foreign Bodies in the Cornea and Their Possible Sequelae.

PMID- 29841533
TI  - Medical Opinion and Movement.

PMID- 29841535
TI  - Microscopical Examination of Tissues during Operation.

PMID- 29841534
TI  - Mr. Bernard Hollander.

PMID- 29841536
TI  - Professional Freedom.

PMID- 29841537
TI  - What Is Disease? What Diagnosis?: II. Medicine, Surgery, and Specialism in
      Relation to Science and Art.

PMID- 29841538
TI  - News and Coming Events.

PMID- 29841539
TI  - Acute Bright's Disease Simulated by Renal Calculus.

PMID- 29841540
TI  - The Common Task.

PMID- 29841541
TI  - Annotations.

PMID- 29841543
TI  - Practical Points.

PMID- 29841542
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841544
TI  - The Melbourne Hospitai.

PMID- 29841546
TI  - The Medical Department of the New Territorial Army.

PMID- 29841545
TI  - Syphilitic Arthritis.

PMID- 29841547
TI  - Jaundice in the New-Born.

PMID- 29841548
TI  - Prescriptions and Dispensing.

PMID- 29841549
TI  - Colostomy.

PMID- 29841550
TI  - The Treatment of Tuberculous Laryngitis.

PMID- 29841551
TI  - Medical Opinion and Movement.

PMID- 29841552
TI  - The Value of Internal Medication in Diseases of the Skin.

PMID- 29841554
TI  - Diphtherial Relapses.

PMID- 29841553
TI  - Diseases of the Nervous System in Old Age.

PMID- 29841555
TI  - Hints to Junior House Surgeons.

PMID- 29841556
TI  - The Treatment of Fractures from a Common-Sense Point of View: X. Fractures of the
      Bones of the Forearm.

PMID- 29841557
TI  - New Appliances and Things Medical.

PMID- 29841558
TI  - On Metastases in Malignant Disease.

PMID- 29841559
TI  - The American Hospital Association.

PMID- 29841560
TI  - The Surreptitious Abolition of Compulsory Vaccination.

PMID- 29841561
TI  - Nature's Method and the Food Supply.

PMID- 29841562
TI  - Professional Freedom.

PMID- 29841564
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841563
TI  - The Problem of Rural Midwifery.

PMID- 29841565
TI  - The London Provident Dispensaries Council.

PMID- 29841566
TI  - Herpes Zoster and Paralysis.

PMID- 29841567
TI  - Some Medical Aspects of the Peace Conference.

PMID- 29841568
TI  - Concerning Operations for Otorrhoea: II. Steele's Original, and the Radical
      Mastoid, Operations.

PMID- 29841569
TI  - Annotations.

PMID- 29841570
TI  - News and Coming Events.

PMID- 29841571
TI  - The Advantages to Be Gained by the Administration of Morphia in Certain
      Conditions.

PMID- 29841572
TI  - The Inebriates Acts, 1897-1900.

PMID- 29841573
TI  - Some Illustrative Cases.

PMID- 29841574
TI  - Dr. Purves Stewart's Reply.

PMID- 29841575
TI  - The Treatment of Tuberculous Laryngitis.

PMID- 29841577
TI  - Religious Equality in Institutions.

PMID- 29841576
TI  - Gonorrhoeal Infection in the Female and Its Treatment.

PMID- 29841578
TI  - Colostomy.

PMID- 29841579
TI  - Hypnotism in Its Relation to Hysteria and to Psychasthenia.

PMID- 29841580
TI  - Professional Freedom.

PMID- 29841582
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841581
TI  - The Treatment of Bacteriuria.

PMID- 29841583
TI  - The Common Task.

PMID- 29841584
TI  - The Early Notification of Births Act.

PMID- 29841585
TI  - Social Problems at the Church Congress.

PMID- 29841586
TI  - Wanted-A State Examination.

PMID- 29841588
TI  - Annotations.

PMID- 29841587
TI  - Rheumatic Pericarditis and Its Consequences.

PMID- 29841590
TI  - Medical Opinion and Movement.

PMID- 29841589
TI  - Story of the Insane from Year to Year.

PMID- 29841591
TI  - Anaesthetic Cases.

PMID- 29841592
TI  - The Treatment of Fractures from a Common-Sense Point of View: XII. Fractures of
      the Shaft of the Femur.

PMID- 29841593
TI  - News and Coming Events.

PMID- 29841594
TI  - Concerning Operations for Otorrhoea: II. Steele's Original, and the Radical
      Mastoid, Operations.

PMID- 29841596
TI  - The Caird Cancer Hospital, Dundee Royal Infirmary.

PMID- 29841595
TI  - Prescriptions and Dispensing.

PMID- 29841597
TI  - The Hospital Officers' Association.

PMID- 29841598
TI  - Injuries to the Eye.

PMID- 29841600
TI  - Indigo-Uria.

PMID- 29841599
TI  - The Prussian Blue Reaction of the Liver in Pernicious Anaemia.

PMID- 29841601
TI  - Medical Opinion and Movement.

PMID- 29841602
TI  - Archaeology and the Collection of Antiques.

PMID- 29841603
TI  - The Treatment of Fractures from a Common-Sense Point of View: XI. Fractures of
      the Neck of the Femur.

PMID- 29841604
TI  - Prescriptions and Dispensing.

PMID- 29841606
TI  - The Third Report of the Royal Commission on Vivisection.

PMID- 29841605
TI  - Colostomy.

PMID- 29841608
TI  - Disease and National Efficiency.

PMID- 29841607
TI  - The New Buildings at St. Bartholomew's Hospital.

PMID- 29841610
TI  - News and Coming Events.

PMID- 29841609
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841611
TI  - Post-Hemiplegic Athetosis.

PMID- 29841613
TI  - St. Mary's Hospital.

PMID- 29841612
TI  - Arterio-Sclerosis.

PMID- 29841615
TI  - Annotations.

PMID- 29841614
TI  - Committees and Justice.

PMID- 29841617
TI  - The Common Form of Dysmenorrhoea of Young Women.

PMID- 29841616
TI  - Acute Yellow Atrophy of the Liver.

PMID- 29841618
TI  - Pathology for General Practitioners: The Apparatus Required for Simple
      Investigations.

PMID- 29841619
TI  - Fretfulness in Infancy.

PMID- 29841620
TI  - The Common Task.

PMID- 29841621
TI  - The Temporary Relief of Turbinal Distension.

PMID- 29841622
TI  - The Neglected Art of Prescription Writing.

PMID- 29841623
TI  - Some Remarks on Puerperal Sapraemia.

PMID- 29841625
TI  - Social and Poor-Law Problems.

PMID- 29841624
TI  - The Operative Treatment of Internal Piles.

PMID- 29841626
TI  - Annotations.

PMID- 29841627
TI  - The Common Task.

PMID- 29841628
TI  - New Appliances and Things Medical.

PMID- 29841630
TI  - The Nurses' Home.

PMID- 29841629
TI  - How to Perform a Post-Mortem Examination: The Experience of a Lifetime, and Its
      Practical Teaching.

PMID- 29841631
TI  - The Grip of the Specialist.

PMID- 29841632
TI  - Pemphigus.

PMID- 29841634
TI  - Where Is "That Man from Sheffield"?

PMID- 29841633
TI  - The Bristol Royal Infirmary Impasse.

PMID- 29841636
TI  - The Treatment of Fractures from a Common-Sense Point of View: VIII. Fracture of
      the Olecranon.

PMID- 29841635
TI  - The Treatment of Frontal Sinusitis.

PMID- 29841637
TI  - Cervico-Facial Actinomycosis.

PMID- 29841638
TI  - What Is a Disease: What Is the Meaning of Diagnosis?

PMID- 29841639
TI  - Raynaud's Disease Affecting Tongue as Well as Extremities: The Tongue as well as
      Extremities Affected.

PMID- 29841640
TI  - Diagram of the Weekly Death Rate in 1907.

PMID- 29841641
TI  - News and Coming Events.

PMID- 29841642
TI  - Medical Opinion and Movement.

PMID- 29841644
TI  - Pathology for General Practitioners.

PMID- 29841643
TI  - The Prevalence of Drug Habits.

PMID- 29841645
TI  - The "Rideal-Walker" Method of Standardising Disinfectants.

PMID- 29841646
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841647
TI  - The Smegma Bacillus and Urinary Tuberculosis.

PMID- 29841648
TI  - The "Ad Hoc" Principle in Local Government.

PMID- 29841649
TI  - King Edward's Hospital Fund.

PMID- 29841650
TI  - The Hospital Sunday Fund.

PMID- 29841651
TI  - King Edward's Hospital Fund for London.

PMID- 29841653
TI  - Further Notes on Compulsory Notification.

PMID- 29841652
TI  - Resident Medical Officers' Department.

PMID- 29841654
TI  - Annotations.

PMID- 29841655
TI  - Some Effects of Adenoids.

PMID- 29841656
TI  - Dislocation of the Shoulder.

PMID- 29841657
TI  - Prescriptions and Dispensing.

PMID- 29841658
TI  - Medical Opinion and Movement.

PMID- 29841659
TI  - The Ultimate Results of Inoperable Gynaecological Cases.

PMID- 29841661
TI  - Some Diseases of the Male Genital System: I. Hydrocele of the Tunica Vaginalis.

PMID- 29841660
TI  - Justus' Test for Syphilis.

PMID- 29841662
TI  - Endothelial Tumours.

PMID- 29841663
TI  - The Incorporate Institute of Hygiene.

PMID- 29841665
TI  - The True Position of the Specialist.

PMID- 29841664
TI  - Annotations.

PMID- 29841666
TI  - Medical Opinion and Movement.

PMID- 29841667
TI  - Pernicious Vomiting of Pregnancy.

PMID- 29841669
TI  - Chronic Colitis.

PMID- 29841668
TI  - A Simple Method of Determining the Blood Coagulation Time.

PMID- 29841671
TI  - St. George's Hospital.

PMID- 29841670
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841673
TI  - Osteo-Arthritis.

PMID- 29841672
TI  - Concerning Operation for Abscess of the Brain Associated with Otorrhoea.

PMID- 29841675
TI  - New Dental Hospital at Melbourne, Australia.

PMID- 29841674
TI  - The Registration of Nursing Homes.

PMID- 29841678
TI  - Protection against Fire in London.

PMID- 29841677
TI  - Medical Education and the London University.

PMID- 29841679
TI  - News and Coming Events.

PMID- 29841680
TI  - Some Medical Haemorrhages.

PMID- 29841681
TI  - "Rudimentary" Forms of Tabes.

PMID- 29841683
TI  - Maragliano's Serum in Phthisis.

PMID- 29841682
TI  - The Treatment of Fractures from a Common-Sense Point of View: XVI. Pott's
      Fracture.

PMID- 29841685
TI  - Infectious Diseases in General Hospitals.

PMID- 29841684
TI  - The War Efficiency of the Medical Volunteer.

PMID- 29841686
TI  - Homes for Inebriates.

PMID- 29841687
TI  - Meteorology as Study and Pastime.

PMID- 29841688
TI  - The Advertisement of Quack Remedies.

PMID- 29841689
TI  - Some Diseases of the Male Genital System: II. The Diagnosis of Vaginal Hydrocele.

PMID- 29841691
TI  - The Hygienic Superiority of Gas Lighting.

PMID- 29841690
TI  - League of Mercy.

PMID- 29841693
TI  - Annotations.

PMID- 29841692
TI  - The Passing of 1907.

PMID- 29841694
TI  - News and Coming Events.

PMID- 29841695
TI  - Infantile OEdema of the Lower Limbs.

PMID- 29841697
TI  - The Three Glass Test in Cases of Pyuria.

PMID- 29841696
TI  - Haemoptysis and Nitrite of Amyl.

PMID- 29841698
TI  - Medical Opinion and Movement.

PMID- 29841699
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841700
TI  - The Failing Heart.

PMID- 29841701
TI  - Dermatitis Venenata.

PMID- 29841702
TI  - The Treatment of Acute Inflammation by Passive Congestion. Bier's Method.

PMID- 29841703
TI  - Empyema.

PMID- 29841704
TI  - The Common Task.

PMID- 29841705
TI  - The Reduction of Adipose Tissue by Fucus Vesiculosus.

PMID- 29841706
TI  - Soot and Smoke.

PMID- 29841707
TI  - The Administration of Charity.

PMID- 29841708
TI  - News and Coming Events.

PMID- 29841709
TI  - Erythema Nodosum.

PMID- 29841710
TI  - The Common Task.

PMID- 29841711
TI  - New Appliances for Hospital Use.

PMID- 29841712
TI  - Infarction and Rupture of the Heart.

PMID- 29841714
TI  - Paratyphoid Fever.

PMID- 29841713
TI  - Laboratory Methods.

PMID- 29841716
TI  - Professional Freedom.

PMID- 29841715
TI  - Erratum: The Diagnosis of Pancreatic Disease.
AB  - [This corrects the article on p. 660 in vol. 42.].

PMID- 29841718
TI  - The Hygiene of the Public Telephone.

PMID- 29841717
TI  - A Supreme National Health Authority.

PMID- 29841719
TI  - How to Perform a Post-Morterm Examination: The Experience of a Lifetime, and Its
      Practical Teaching.

PMID- 29841721
TI  - Race Progress and the Declining Birth-Rate.

PMID- 29841720
TI  - Sane Persons in Asylums.

PMID- 29841722
TI  - New Infirmary for the Wharfedale Union at Otley, Yorkshire.

PMID- 29841723
TI  - The Bristol Royal Infirmary Impasse.

PMID- 29841724
TI  - The Nursing Institute.

PMID- 29841725
TI  - The Habits of the Medical Student Past and Present.

PMID- 29841726
TI  - Annotations.

PMID- 29841727
TI  - Prescriptions and Dispensing.

PMID- 29841728
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841729
TI  - The Treatment of Fractures from a Common-Sense Point of View: VII. Fractures of
      the Upper End of the Humerus.

PMID- 29841730
TI  - Medical Opinion and Movement.

PMID- 29841731
TI  - The Poor-Law Infirmary.

PMID- 29841733
TI  - The Registration of Nursing Homes.

PMID- 29841732
TI  - Gravel and Stone. Clinical Remarks on Their Formation and Treatment.

PMID- 29841735
TI  - The Poplar Hospital for Accidents.

PMID- 29841734
TI  - Annotations.

PMID- 29841736
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841737
TI  - The Medical Inspection of Children in Public Elementary Schools.

PMID- 29841738
TI  - Pensions and the Medical Profession.

PMID- 29841739
TI  - News and Coming Events.

PMID- 29841740
TI  - The Persistence of Typhoid Bacilli in Organs for Years.

PMID- 29841742
TI  - The Hampstead General Hospital.

PMID- 29841741
TI  - Stains for Fat.

PMID- 29841743
TI  - A Bill for the Prevention of Premature Burial.

PMID- 29841744
TI  - The Medical Inspection of School Children.

PMID- 29841745
TI  - Medical Opinion and Movement.

PMID- 29841746
TI  - Osteo-Arthritis.

PMID- 29841747
TI  - The Use and Abuse of Soap.

PMID- 29841748
TI  - Local Applications to the Upper Air Passages.

PMID- 29841749
TI  - Treatment of Pulmonary Phthisis.

PMID- 29841750
TI  - The Royal Free Hospital.

PMID- 29841752
TI  - The Treatment of Fractures from a Common-Sense Point of View: XV. Fractures of
      the Tibia and Fibula.

PMID- 29841751
TI  - Senile Respiratory Disorders.

PMID- 29841753
TI  - Prescriptions and Dispensing.

PMID- 29841754
TI  - Rudimentary Forms of Disseminated Sclerosis.

PMID- 29841755
TI  - Some Diseases of the Male Genital System: III. The Treatment of Vaginal
      Hydrocele.

PMID- 29841757
TI  - Quackery and Its Prevention.

PMID- 29841756
TI  - Medical Education and the London University.

PMID- 29841759
TI  - News and Coming Events.

PMID- 29841758
TI  - Two Simple Methods of Curing Pediculosis Capitis Quickly.

PMID- 29841760
TI  - Hospital Construction.

PMID- 29841761
TI  - Bacteriology and the Medical Treatment of Disease.

PMID- 29841762
TI  - Secret Remedies and Branded Products.

PMID- 29841763
TI  - Blood Coagulation Time in Disease.

PMID- 29841764
TI  - Hospital Progress in 1907.

PMID- 29841765
TI  - The R.M.O. and the County Court: I. Things to Keep in Mind.

PMID- 29841766
TI  - Rhinitis Sicca.

PMID- 29841767
TI  - Sleeping Sickness.

PMID- 29841768
TI  - Social and Poor-Law Problems.

PMID- 29841769
TI  - Self-Sacrifice or Cowardice.

PMID- 29841770
TI  - Medical Opinion and Movement.

PMID- 29841771
TI  - The General Examination of the Child's Skin.

PMID- 29841772
TI  - Soot and Smoke.

PMID- 29841773
TI  - Empyema-II.

PMID- 29841774
TI  - Annotations.

PMID- 29841775
TI  - Retroversion of the Gravid Uterus.

PMID- 29841776
TI  - Medical Opinion and Movement.

PMID- 29841777
TI  - Old Masters of Medicine.

PMID- 29841778
TI  - Longitudinal and Other Sinus Thrombosis.

PMID- 29841779
TI  - Diseases of the Tear Passages.

PMID- 29841780
TI  - Overworked Matrons: Educate the Committees.

PMID- 29841782
TI  - Some Points in the Treatment of Chorea.

PMID- 29841781
TI  - The Need for Trained Workhouse Matrons.

PMID- 29841783
TI  - The Common Task.

PMID- 29841784
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841786
TI  - Annotations.

PMID- 29841785
TI  - A Discussion on the Complications of Pneumonia.

PMID- 29841787
TI  - The Ramsey Cottage Hospital.

PMID- 29841788
TI  - Concerning Operations for Otorrhoea: III. With Lateral Sinus Thrombosis.

PMID- 29841789
TI  - A Case of Red Granular Kidney.

PMID- 29841790
TI  - News and Coming Events.

PMID- 29841791
TI  - Prescriptions and Dispensing.

PMID- 29841792
TI  - Gastric Digestion in Babies.

PMID- 29841793
TI  - Liability of Operators and Anaesthetists.

PMID- 29841794
TI  - Fibro Adenomata of the Breast.

PMID- 29841795
TI  - Some Diseases of the Male Genital System: IV. The Rarer Forms of Hydrocele.

PMID- 29841797
TI  - King Edward's Hospital Fund for London.

PMID- 29841796
TI  - Spinal Caries.

PMID- 29841798
TI  - Current Hospital Topics.

PMID- 29841799
TI  - The Physician in Art.

PMID- 29841800
TI  - Injuries to the Eye.

PMID- 29841801
TI  - Medical Education and the London University.

PMID- 29841803
TI  - The Sick and Infirm.

PMID- 29841802
TI  - Abdominal Tuberculosis in Childhood.

PMID- 29841804
TI  - Albuminuria in Phthisis.

PMID- 29841805
TI  - Diagram of the Weekly Death Rate in 1907.

PMID- 29841806
TI  - Maternal Nursing.

PMID- 29841807
TI  - Prescriptions and Dispensing.

PMID- 29841809
TI  - Annotations.

PMID- 29841808
TI  - Practical Points.

PMID- 29841810
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841811
TI  - Hyperpyrexia.

PMID- 29841813
TI  - The Lymphatic Glands of the Face.

PMID- 29841812
TI  - The Treatment of Fractures from a Common-Sense Point of View: XIV. Fractures in
      the Neighbourhood of the Knee-Joint.

PMID- 29841815
TI  - Spontaneous Fragmentation of Urinary Calculi.

PMID- 29841814
TI  - News and Coming Events.

PMID- 29841816
TI  - Relapses in Diphtheria.

PMID- 29841817
TI  - Concerning Operations for Otorrhoea.

PMID- 29841819
TI  - Medical Opinion and Movement.

PMID- 29841818
TI  - The Cinematograph in Medicine.

PMID- 29841821
TI  - The Bristol Royal Infirmary.

PMID- 29841820
TI  - The Registration of Nursing Homes.

PMID- 29841822
TI  - Picric Acid Poisoning.

PMID- 29841823
TI  - Nurse-Matrons', Sisters', and Dispensers' Certificates.

PMID- 29841824
TI  - Some Medico-Legal Reminiscences.

PMID- 29841825
TI  - The Cold Summer and the Death Rate.

PMID- 29841827
TI  - Some of the Newer Dermatological Remedies and Their Value.

PMID- 29841826
TI  - The Medical Graduates' College and Polyclinic.

PMID- 29841829
TI  - The "Referee" Children's Dinner Fund.

PMID- 29841828
TI  - Hospitals for the Paralysed.

PMID- 29841830
TI  - Diseases of Twins.

PMID- 29841831
TI  - Medical Students as Nurses-II.

PMID- 29841832
TI  - The Treatment of Fractures from a Common-Sense Point of View: XIII. Fracture of
      the Patella.

PMID- 29841833
TI  - The Significance of Persistory Pyrexia.

PMID- 29841834
TI  - Medical Opinion and Movement.

PMID- 29841835
TI  - New Appliances and Things Medical.

PMID- 29841836
TI  - The Royal Free Hospital.

PMID- 29841837
TI  - Acetonaemia and Acetonuria.

PMID- 29841838
TI  - Local Applications to the Upper Air Passages.

PMID- 29841840
TI  - Epithelioma of the Penis.

PMID- 29841839
TI  - The Late Mr. Reginald Lund.

PMID- 29841841
TI  - Hospitals and Suicidal Patients.

PMID- 29841842
TI  - The Bismuth Skiagram in Investigating Gastro Intestinal Disorders.

PMID- 29841843
TI  - Temperature Variations in Pulmonary Tuberculosis.

PMID- 29841844
TI  - Brachial Neuritis and Similar Conditions Involving the Arms.

PMID- 29841845
TI  - The Importance of Localising the Heart's Apex Beat.

PMID- 29841847
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841846
TI  - Professional Freedom.

PMID- 29841849
TI  - Annotations.

PMID- 29841848
TI  - Sanatorium Experiences.

PMID- 29841850
TI  - The Registration of Nursing Homes.

PMID- 29841851
TI  - The Charite Hospital, Paris.

PMID- 29841852
TI  - Infectious Diseases in General Hospitals.

PMID- 29841854
TI  - The Senile Cardio-Vascular System.

PMID- 29841853
TI  - Painless Effusion into the Knee-Joint.

PMID- 29841855
TI  - The Sanitary Organisation of the Territorial Army.

PMID- 29841856
TI  - Medical Students as Nurses-I.

PMID- 29841858
TI  - Foreign Bodies in the Air Passages.

PMID- 29841857
TI  - Insanity and Mental Disorder.

PMID- 29841860
TI  - The Registration of Nursing Homes.

PMID- 29841859
TI  - Some Notes on Progress in Medicine.

PMID- 29841861
TI  - Simulation of Phthisis by Disease of Pharynx and Nose.

PMID- 29841862
TI  - Anaemia in Tropical Diseases.

PMID- 29841863
TI  - Warrington Infirmary.

PMID- 29841864
TI  - Medical Opinion and Movement.

PMID- 29841866
TI  - Gynaecology in General Practice.

PMID- 29841865
TI  - On Phagocytosis.

PMID- 29841868
TI  - Medical Men, Medical Papers, and Insurance.

PMID- 29841867
TI  - Chronic Diseases of the Joints.

PMID- 29841870
TI  - The Optic Nerve and the Accessory Sinuses of the Nose.

PMID- 29841869
TI  - Pyrexia in Malignant Disease of the Liver.

PMID- 29841872
TI  - Social and Poor-Law Problems.

PMID- 29841871
TI  - The Official Scheme for the Medical Service of the Territorial Army.

PMID- 29841873
TI  - The Tendency of Certain Diseases to Die out.

PMID- 29841874
TI  - Trigeminal Neuralgia and Its Surgical Treatment.

PMID- 29841876
TI  - Hospital Finance at Its Best.

PMID- 29841875
TI  - Thalamic Hemiplegia.

PMID- 29841878
TI  - Annotations.

PMID- 29841877
TI  - Otitis Media in Infancy and Early Childhood.

PMID- 29841879
TI  - News and Coming Events.

PMID- 29841880
TI  - Miss Nightingale and the City of London.

PMID- 29841881
TI  - Trypanosomiasis.

PMID- 29841882
TI  - Practical Hints for X-Ray Work.

PMID- 29841884
TI  - Medical Opinion and Movement.

PMID- 29841883
TI  - Annotations.

PMID- 29841885
TI  - Authority and Teaching.

PMID- 29841887
TI  - Fever Nursing.

PMID- 29841886
TI  - Clean or Pasteurised Milk.

PMID- 29841889
TI  - Changes in the Vaccination Laws.

PMID- 29841888
TI  - Two Cases of Restlessness-I.

PMID- 29841890
TI  - Some Diseases of the Male Genital System: XI. Syphilitic Orchitis.

PMID- 29841891
TI  - Acute Nephritis with Extreme Haematuria.

PMID- 29841892
TI  - Current Hospital Topics.

PMID- 29841893
TI  - Musical Bruits and Accidents to Workmen.

PMID- 29841894
TI  - Social and Poor Law Problems.

PMID- 29841895
TI  - Nasal Obstruction and Operation for Rectifying Obstructive Deformities of the
      Nasal Septum.

PMID- 29841896
TI  - Operations for Otorrhoea.

PMID- 29841897
TI  - Economy in Nursing Department.

PMID- 29841898
TI  - Annotations.

PMID- 29841899
TI  - Secretin.

PMID- 29841900
TI  - The Hospital Chapel.

PMID- 29841902
TI  - Still-Birth Certificates.

PMID- 29841901
TI  - The Spontaneous Disappearance of Malignant Growths.

PMID- 29841904
TI  - News and Coming Events.

PMID- 29841903
TI  - Veronal Rashes.

PMID- 29841905
TI  - Influenza in Babies.

PMID- 29841906
TI  - Prescriptions and Dispensing.

PMID- 29841908
TI  - Medical Opinion and Movement.

PMID- 29841907
TI  - The Vagaries of the Drug Market.

PMID- 29841909
TI  - A Demonstration of Selected Skin Cases.

PMID- 29841910
TI  - Damages for Libel: Successful Action by a Medical Man.

PMID- 29841912
TI  - The Royal Free Hospital.

PMID- 29841911
TI  - Movable Kidney-II.

PMID- 29841913
TI  - Sex and Character.

PMID- 29841914
TI  - The Children's Bill.

PMID- 29841916
TI  - Intestinal Worms in Children and Their Treatment.

PMID- 29841915
TI  - Spinal Hemiplegia-II: With Anaesthesia on the Same Side.

PMID- 29841918
TI  - Uterine Polypi-I.

PMID- 29841917
TI  - The Hospital Chapel.

PMID- 29841919
TI  - Heart-Block.

PMID- 29841920
TI  - Miniature Rifle Shooting.

PMID- 29841921
TI  - The Certainties and Uncertainties of Tuberculosis.

PMID- 29841922
TI  - The Skin in Winter.

PMID- 29841923
TI  - News and Coming Events.

PMID- 29841924
TI  - Psoas Abscess.

PMID- 29841926
TI  - Medical Opinion and Movement.

PMID- 29841925
TI  - Nephritis Associated with Scarlet Fever.

PMID- 29841927
TI  - Cancer of the Larynx.

PMID- 29841929
TI  - The London Hospital.

PMID- 29841928
TI  - Prostatectomy and Bladder Stone.

PMID- 29841930
TI  - Some Diseases of the Male Genital System: VI. Retained Testis.

PMID- 29841931
TI  - The Hospitals of Paris.

PMID- 29841932
TI  - The Poor-Law Midwifery Schools.

PMID- 29841933
TI  - The Declining Birth-Rate.

PMID- 29841935
TI  - Hospital Sunday Collections in London in 1907.

PMID- 29841934
TI  - The Accidents Which May Happen to Ovarian Cystic Tumours.

PMID- 29841936
TI  - Annotations.

PMID- 29841937
TI  - Intestinal Digestion in Babies.

PMID- 29841938
TI  - Concerning Operations for Otorrhoea: III. With Laterial Sinus Thrombosis
      (concluded).

PMID- 29841939
TI  - On the Arrangements for the Operation Theatre for a Small Hospital.

PMID- 29841941
TI  - A Mental Clinic for London.

PMID- 29841940
TI  - Surgery and the General Practitioner.

PMID- 29841942
TI  - Some Conditions Which May Simulate Appendicitis.

PMID- 29841943
TI  - News and Coming Events.

PMID- 29841945
TI  - Bilateral Facial Paralysis.

PMID- 29841944
TI  - Medical Opinion and Movement.

PMID- 29841946
TI  - The Prognosis of Valvular Heart Disease.

PMID- 29841947
TI  - The Royal Commission on Whiskey and Potable Spirits.

PMID- 29841948
TI  - The Modern Treatment of Ophthalmia Neonatorum.

PMID- 29841949
TI  - Annotations.

PMID- 29841950
TI  - The Case-History of Haemorrhages in the Early Months of Pregnancy.

PMID- 29841951
TI  - Secret Remedies and Branded Products-III.

PMID- 29841952
TI  - Dermatology.

PMID- 29841953
TI  - Practical Sociology: Ill-Health as a Cause of Pauperism.

PMID- 29841954
TI  - Answers to Correspondents.

PMID- 29841955
TI  - Graves' Disease and Acute Rheumatism.

PMID- 29841956
TI  - Fever Nursing.

PMID- 29841957
TI  - Pneumothorax.

PMID- 29841958
TI  - An Interesting Outbreak of Typhoid Fever.

PMID- 29841960
TI  - The Diseases of Historical Characters.

PMID- 29841959
TI  - Movable Kidney-I.

PMID- 29841961
TI  - Fever Nursing.

PMID- 29841962
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841963
TI  - Clean Milk or Pasteurised Milk.

PMID- 29841964
TI  - Annotations.

PMID- 29841965
TI  - Some Diseases of the Male Genital System: X. Tuberculosis of the Testis and
      Epididymis (Continued).

PMID- 29841966
TI  - An Impasse at the Royal Victoria Infirmary, Newcastle.

PMID- 29841967
TI  - News and Coming Events.

PMID- 29841968
TI  - Claudius Galenus and His System.

PMID- 29841969
TI  - Social and Poor-Law Problems.

PMID- 29841970
TI  - Medical Opinion and Movement.

PMID- 29841972
TI  - Chronic Rheumatism and Rheumatoid Arthritis.

PMID- 29841971
TI  - Lupus of the Upper Air Passages.

PMID- 29841974
TI  - Posterior Basal and Epidemic Cerebro-Spinal Meningitis.

PMID- 29841973
TI  - The Relation of Post Diphtheritic Paralysis to Antitoxin.

PMID- 29841975
TI  - Valvular Murmurs in Relation to the Treatment of Cardiac Disease.

PMID- 29841978
TI  - Annotations.

PMID- 29841976
TI  - Pure Carbolic in the Treatment of Boils.

PMID- 29841977
TI  - Alcohol and Physical Deterioration.

PMID- 29841979
TI  - Medical Opinion and Movement.

PMID- 29841980
TI  - News and Coming Events.

PMID- 29841981
TI  - Deaths under Anaesthetics.

PMID- 29841982
TI  - Some Diseases of the Male Genital System: VIII. Tuberculous Disease of the Testis
      and Epididymis.

PMID- 29841983
TI  - Solution to the Case for Diagnosis.

PMID- 29841984
TI  - Von Noorden's Dietary in Mucous Colitis.

PMID- 29841985
TI  - On the Use of Pessaries.

PMID- 29841987
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29841986
TI  - The Mental Disorders of Childhood.

PMID- 29841988
TI  - Tuberculous Disease Affecting the Tarsus.

PMID- 29841989
TI  - Graduate Study in London.

PMID- 29841990
TI  - New Appliances and Things Medical.

PMID- 29841991
TI  - The Admission of Women to the London Colleges.

PMID- 29841992
TI  - The Examination of Urine for Sugar.-II.

PMID- 29841993
TI  - Over-Worked Matrons.

PMID- 29841994
TI  - On Certain Skin Diseases.

PMID- 29841995
TI  - Acute Gout.-II.

PMID- 29841997
TI  - Thoracic Aortic Aneurysms.

PMID- 29841996
TI  - The Dysphagia of Tuberculous Laryngitis.

PMID- 29841998
TI  - Operations for Otorrhoea.

PMID- 29841999
TI  - Typhoid Carriers.

PMID- 29842000
TI  - News and Coming Events.

PMID- 29842001
TI  - Secret Remedies and Branded Products-IV.

PMID- 29842002
TI  - Annotations.

PMID- 29842003
TI  - X-Rays and Other Tests for Death.

PMID- 29842004
TI  - King Edward's Hospital Fund for London.

PMID- 29842005
TI  - District Nursing Committees: A Danger.

PMID- 29842006
TI  - Some Diseases of the Male Genital System: XII. Malignant Disease of the Testis.

PMID- 29842007
TI  - Functional Diseases.

PMID- 29842008
TI  - The Legal Liability of the Anaesthetist.

PMID- 29842009
TI  - Prescriptions and Dispensing.

PMID- 29842010
TI  - Bilharziasis.

PMID- 29842011
TI  - The Diagnosis and Treatment of Adenoids.

PMID- 29842012
TI  - Uterine Polypi.-II.

PMID- 29842014
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29842013
TI  - Haemorrhage after Operative Cure of Intussusception.

PMID- 29842016
TI  - Re-Education of the Tabetic.

PMID- 29842015
TI  - The General Practitioner and Research.

PMID- 29842017
TI  - Absorption of Drugs through the Skin.

PMID- 29842018
TI  - Medical Opinion and Movement.

PMID- 29842020
TI  - Some Diseases of the Male Genital System: IX. Tuberculosis of the Testis and
      Epididymis.

PMID- 29842019
TI  - Rodent Ulcer.

PMID- 29842021
TI  - Hospital Administration: Hospital Committees and Overwork.

PMID- 29842023
TI  - Surgery and the General Practitioner.

PMID- 29842022
TI  - Dysphagia in Tuberculous Laryngitis.

PMID- 29842025
TI  - Details of Medical Inspection.

PMID- 29842024
TI  - Anti-Typhoid Vaccine.

PMID- 29842026
TI  - Medical Opinion and Movement.

PMID- 29842027
TI  - The Experimental Transmission of Cancer.

PMID- 29842028
TI  - The R.M.O. and the County Court: II. Medical Fees in Legal Cases.

PMID- 29842029
TI  - Dermatology.

PMID- 29842031
TI  - Annotations.

PMID- 29842030
TI  - News and Coming Events.

PMID- 29842032
TI  - Prescriptions and Dispensing.

PMID- 29842033
TI  - The Cortical Centre for Hearing.

PMID- 29842035
TI  - Spinal Hemiplegia.

PMID- 29842034
TI  - The Common Task.

PMID- 29842037
TI  - Intra-Thoracic New Growths.

PMID- 29842036
TI  - Graduate Study in London.

PMID- 29842038
TI  - Puerperal Fever in London in 1906.

PMID- 29842039
TI  - Annotations.

PMID- 29842040
TI  - Some Surgical Complications of Typhoid Fever.

PMID- 29842041
TI  - Isolation Hospital Expenses.

PMID- 29842043
TI  - A Case of Spontaneous Rupture of a Coronary Artery.

PMID- 29842042
TI  - Some Diseases of the Male Genital System: V. Haematocele.

PMID- 29842044
TI  - Antistreptococcic Serum in Phthisis with Cavitation.

PMID- 29842045
TI  - A Note on Co-Existent Infectious Diseases.

PMID- 29842046
TI  - Syphilitic Disease of the Joints.

PMID- 29842048
TI  - Proprietary Preparations.

PMID- 29842047
TI  - Medical Opinion and Movement.

PMID- 29842049
TI  - Current Hospital Topics.

PMID- 29842050
TI  - One More Central Authority for Charity.

PMID- 29842051
TI  - Oxygen Inhalations Should Be Warmed.

PMID- 29842052
TI  - Report of the Medical Officer of the Education Committee of the London County
      Council.

PMID- 29842054
TI  - Architecture and History.

PMID- 29842053
TI  - Diagram of the Weekly Death Rate in 1907.

PMID- 29842056
TI  - News and Coming Events.

PMID- 29842055
TI  - Cancer of the Larynx.

PMID- 29842057
TI  - Practical Notes on Diagnosis and Treatment.

PMID- 29842058
TI  - Rat Extermination.

PMID- 29842059
TI  - "The Tribune" Exhibition of Winter Foods and Drinks.

PMID- 29842060
TI  - Streptothrix Infections.

PMID- 29842061
TI  - Northampton General Hospital.

PMID- 29842062
TI  - Acute Nephritis with Extreme Haematuria.

PMID- 29842063
TI  - Cysts in the Floor of the Mouth.

PMID- 29842064
TI  - A Case of Ischaemic Paralysis.

PMID- 29842066
TI  - Acute Intestinal Obstruction with Abnormal Features.

PMID- 29842065
TI  - Endometritis and the Operation of Curettage.

PMID- 29842067
TI  - Proprietary Preparations.

PMID- 29842068
TI  - New Appliances and Things Medical.

PMID- 29842069
TI  - Medical Opinion and Movement.

PMID- 29842071
TI  - Old Masters of Medicine.

PMID- 29842070
TI  - A Suggested Reform of the Lunacy Laws.

PMID- 29842073
TI  - The United Kingdom Hospitals Conference in March.

PMID- 29842072
TI  - The Treatment of Some Common Ailments.

PMID- 29842074
TI  - Prescriptions and Dispensing.

PMID- 29842075
TI  - Social and Poor-Law Problems.

PMID- 29842077
TI  - Dr. Newsholme, Medical Officer of the Local Government Board.

PMID- 29842076
TI  - Asthma in Infants and Young Children.

PMID- 29842079
TI  - News and Coming Events.

PMID- 29842078
TI  - Annotations.

PMID- 29842080
TI  - Social Questions and the Medical Profession.

PMID- 29842081
TI  - The Poor-Law Midwifery Schools.

PMID- 29842082
TI  - A Case for Diagnosis.

PMID- 29842083
TI  - Wanted, Lady Mission Doctors.

PMID- 29842085
TI  - Acute Gout.

PMID- 29842084
TI  - Social and Poor-Law Problems.

PMID- 29842087
TI  - Wanted, Lady Mission Doctors.

PMID- 29842086
TI  - Unqualified Practice, the Medical Profession and the Public.

PMID- 29842088
TI  - Should Consumptives Be Segregated?

PMID- 29842089
TI  - Transmission of Acquired Characteristics.

PMID- 29842090
TI  - Secret Remedies and Proprietary Products.-II.

PMID- 29842091
TI  - Oral Sepsis and Its Relation to Abdominal Disease.

PMID- 29842093
TI  - The Poor-Law Midwifery Schools.

PMID- 29842092
TI  - The North-Eastern Hospital for Children.

PMID- 29842094
TI  - Tonbridge Cottage Hospital.

PMID- 29842095
TI  - A Case for Diagnosis.

PMID- 29842096
TI  - Prescriptions and Dispensing.

PMID- 29842097
TI  - Psoas Abscess.-II.

PMID- 29842098
TI  - The Examination of the Urine for Sugar.

PMID- 29842099
TI  - The Common Task.

PMID- 29842100
TI  - Medical Opinion and Movement.

PMID- 29842101
TI  - The Training of Officers.

PMID- 29842103
TI  - Annotations.

PMID- 29842102
TI  - News and Coming Events.

PMID- 29842104
TI  - The Mission to Lepers in India and the East.

PMID- 29842105
TI  - Some Diseases of the Male Genital System: VII. The Treatment of Retained Testis.

PMID- 29842106
TI  - House Appointments at Small Hospitals.

PMID- 29842108
TI  - The Treatment of Periosteal Sarcoma.

PMID- 29842107
TI  - The London Hospital.

PMID- 29842109
TI  - Degrees and Diplomas.

PMID- 29842111
TI  - A Criticism of Homoeopathy.

PMID- 29842110
TI  - The Causation of Sex.

PMID- 29842113
TI  - The Bristol Hospital for Sick Children.

PMID- 29842112
TI  - Literary Notes.

PMID- 29842114
TI  - St. Bartholomew's Hospital Appeal.

PMID- 29842115
TI  - The Agnes Memorial Sanatorium at Denver, Colorado.

PMID- 29842116
TI  - Hospital Architecture and Construction.

PMID- 29842117
TI  - The College of Nursing.

PMID- 29842119
TI  - A Serious Question.

PMID- 29842118
TI  - The Profession and the National Health Commissioners: Incapable of Work.

PMID- 29842120
TI  - The Alleged Inhumanity at Guy's.

PMID- 29842122
TI  - Tuberculosis Topics.

PMID- 29842121
TI  - Questions and Answers.

PMID- 29842123
TI  - A Drab, Inexpressibly Dreary Neighbourhood.

PMID- 29842124
TI  - Nursing Affairs in Ireland.

PMID- 29842126
TI  - Tragedies of War Bread.

PMID- 29842125
TI  - Discharged Soldiers as Male Attendants.

PMID- 29842127
TI  - The Latest Types of Invalid Lifter.

PMID- 29842128
TI  - Legal Notes for Institutional Workers.

PMID- 29842129
TI  - A London Pharmacist's Forecast.

PMID- 29842130
TI  - Queen Alexandra and King Edward Memorials.

PMID- 29842132
TI  - Hospital Needs.

PMID- 29842131
TI  - Ward Fireplaces: A New Design.

PMID- 29842133
TI  - Ill-Health Amongst Plymouth School Children.

PMID- 29842135
TI  - Distribution Committee's Report and Awards.

PMID- 29842134
TI  - The Late Matron and Worcester General Infirmary.

PMID- 29842137
TI  - Institutional Notes and News.

PMID- 29842136
TI  - Pure Air in Hospitals.

PMID- 29842139
TI  - Parliament and Publications.

PMID- 29842138
TI  - News and Events of the Week.

PMID- 29842141
TI  - Parliament and Publications.

PMID- 29842142
TI  - Parliament and Publications.

PMID- 29842140
TI  - Parliament and Publications.

PMID- 29842143
TI  - Erratum: A Correction.
AB  - [This corrects the article on p. 221 in vol. 50.].

PMID- 29842144
TI  - The Views of Hospital Secretaries.

PMID- 29842145
TI  - News and Events of the Week.

PMID- 29842146
TI  - New Appliances & Things Medical.

PMID- 29842147
TI  - News and Events of the Week.

PMID- 29842148
TI  - New Appliances & Things Medical.

PMID- 29842149
TI  - News and Events of the Week.

PMID- 29842150
TI  - Parliament and Publications.

PMID- 29842151
TI  - Institutional Notes and News.

PMID- 29842153
TI  - Central Midwives Board for Scotland.

PMID- 29842152
TI  - Everybody's Page.

PMID- 29842154
TI  - The Oxford Plan for Devonshire?

PMID- 29842155
TI  - Transplantation of Eyes.

PMID- 29842157
TI  - Sailors and Defective Vision.

PMID- 29842156
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29842159
TI  - Patience.

PMID- 29842158
TI  - New Drugs, Appliances, and Things Medical.

PMID- 29842161
TI  - Annual Meeting of Constituents.

PMID- 29842160
TI  - Erratum.
AB  - [This corrects the article on p. 271 in vol. 67.].

PMID- 29842162
TI  - H.R.H. the Prince of Wales in the Chair.

PMID- 29842163
TI  - A Record of Wonderful Development.

PMID- 29842164
TI  - The Meaning of Research.

PMID- 29842165
TI  - The State in Relation to Chronic Disease.

PMID- 29842166
TI  - Hygiene and the Health of Our Children.

PMID- 29842167
TI  - After War, Armistice. After Armistice, Peace?

PMID- 29842168
TI  - The Institutional Worker.

PMID- 29842169
TI  - The True Inwardness of State Registration.

PMID- 29842170
TI  - Hospital and Institutional News.

PMID- 29842171
TI  - Some Urgently Needed Reforms.

PMID- 29842172
TI  - Some Views on the Present Crisis.

PMID- 29842173
TI  - Round the Hospitals.

PMID- 29842175
TI  - Description from the Account of the German Army Chaplain Paul De Seur.

PMID- 29842174
TI  - The Matron's Winter Holiday.

PMID- 29842176
TI  - Passing Positions of the Moment.

PMID- 29842177
TI  - How to Get All the Money Required.

PMID- 29842178
TI  - The Institutional Worker.

PMID- 29842179
TI  - Australian Notes.

PMID- 29842180
TI  - St. Dunstan's-And after.

PMID- 29842181
TI  - "Ierne" on Guard.

PMID- 29842183
TI  - Walking the Hospital in Johannesburg.

PMID- 29842182
TI  - After-War Developments for the Voluntary Hospital.

PMID- 29842184
TI  - Round the Hospitals.

PMID- 29842185
TI  - Parliament and the Professions.

PMID- 29842187
TI  - The Grafting of Glands: A Record of French Experience.

PMID- 29842186
TI  - The Nurses' Enabling Bill.

PMID- 29842188
TI  - Pituitary Extract: Some Applications and Their Value.

PMID- 29842189
TI  - Hospital and Institutional News.

PMID- 29842191
TI  - Establishment of Degrees in Commerce.

PMID- 29842190
TI  - Hospitals and Mental Cases.

PMID- 29842192
TI  - Care of the Disabled.

PMID- 29842193
TI  - Awakening Efforts in Hospital Finance.

PMID- 29842194
TI  - Film Pictures of Normal Labour and Delivery.

PMID- 29842195
TI  - A Taste for Horseflesh: Dr. Killick Millard's Experience.

PMID- 29842197
TI  - Parliament and the Professions.

PMID- 29842196
TI  - Hospital and Institutional News.

PMID- 29842199
TI  - Round the Hospitals.

PMID- 29842198
TI  - Flies and Dysentery.

PMID- 29842200
TI  - Is It Her Swan Song?

PMID- 29842201
TI  - A Romance of Charity.

PMID- 29842203
TI  - Some Notes from the Olympia Motor Show.

PMID- 29842202
TI  - Oxford's Great Memorial to Valiant Men.

PMID- 29842204
TI  - Must They Be Driven to a Last Refuge?

PMID- 29842205
TI  - Some Nurses' Problems.

PMID- 29842206
TI  - A "Memorial" Hospital.

PMID- 29842207
TI  - On the Etiology of Certain Cases of Alopecia.

PMID- 29842208
TI  - Mental Nursing.

PMID- 29842209
TI  - Some Varieties and Their Treatment.

PMID- 29842210
TI  - The Pause before State Registration.

PMID- 29842212
TI  - Australian Notes.

PMID- 29842211
TI  - Round the Hospitals.

PMID- 29842214
TI  - Voluntary Hospital Finance. The Position and Outlook Better.

PMID- 29842213
TI  - The Hospital Journals and Gazettes.

PMID- 29842216
TI  - Parliament and the Profession.

PMID- 29842215
TI  - The Administration of Ovarian and Other Extracts.

PMID- 29842218
TI  - The Institutional Worker.

PMID- 29842217
TI  - A Medical Education for Working Class Children.

PMID- 29842219
TI  - Will Her Citizens Lead Voluntary Hospital Finance?

PMID- 29842220
TI  - Hospital Library.

PMID- 29842221
TI  - A Lesson of the War.

PMID- 29842223
TI  - Unpopularity of Private Nursing with Hospital Staffs.

PMID- 29842222
TI  - Society for the Prevention and Relief of Cancer.

PMID- 29842224
TI  - Their True Relationship.

PMID- 29842226
TI  - The Opportunity for the Wise.

PMID- 29842225
TI  - Hospital and Institutional News.

PMID- 29842227
TI  - The Fundus Oculi: A Review of Some Common Disorders.

PMID- 29842228
TI  - The Hospitals' Huge Contribution to the Cost of the War.

PMID- 29842229
TI  - "Ierne" at Fault.

PMID- 29842230
TI  - The Forty-Eight-Hour Week.

PMID- 29842231
TI  - The Wise Women of Nursing.

PMID- 29842232
TI  - Statistical Report of Expenditure of 109 London Hospitals.

PMID- 29842233
TI  - The New Panel Agreements.

PMID- 29842235
TI  - The Treatment of Gonococcal Infections: A Review of Modern Developments.

PMID- 29842234
TI  - Unpopularity of Private Nursing with Hospital Staffs.

PMID- 29842236
TI  - Effect of Hot Weather on Fatigue.

PMID- 29842237
TI  - Scarlet Fever Outbreaks: With Special Reference to the Latest Epidemics.

PMID- 29842238
TI  - The Institutional Worker.

PMID- 29842239
TI  - Nursing and Municipal Economy.

PMID- 29842240
TI  - Round the Hospitals.

PMID- 29842241
TI  - The Hospital Crisis: How Not to Get Money.

PMID- 29842242
TI  - The Demand for Reconstruction.

PMID- 29842243
TI  - What the College of Nursing Has Accomplished.

PMID- 29842245
TI  - Some Thoughts for Nurses.

PMID- 29842244
TI  - The Necessity for the Human Element.

PMID- 29842247
TI  - The College of Nursing's Traducers.

PMID- 29842246
TI  - Hospital and Institutional News.

PMID- 29842248
TI  - Parliament and the Professions.

PMID- 29842249
TI  - Needle, Holder and Ligature in One Instrument.

PMID- 29842250
TI  - The Registration of Nurses Bill.

PMID- 29842251
TI  - Solving the Hospital Financial Crisis.

PMID- 29842252
TI  - Hospital and Institutional News.

PMID- 29842253
TI  - Is the Cost per Occupied Bed the Only Criterion of Efficency and Economy?

PMID- 29842254
TI  - Health Teaching for the Young.

PMID- 29842255
TI  - The Early Evolution of Surgery.

PMID- 29842256
TI  - The Probationers' Forty-Eight-Hour Week.

PMID- 29842257
TI  - Views of the L.C.C.

PMID- 29842258
TI  - Round the Hospitals.

PMID- 29842259
TI  - The Institutional Worker.

PMID- 29842260
TI  - The Corruption of Charity.

PMID- 29842261
TI  - Parliament and the Professions.

PMID- 29842262
TI  - King Edward's Hospital Fund for London.

PMID- 29842263
TI  - King George's Fund for Sailors.

PMID- 29842264
TI  - Lord Knutsford's 'Impossible'.

PMID- 29842265
TI  - The Work Ahead and How to Accomplish It.

PMID- 29842266
TI  - Christmas in the Hospitals.

PMID- 29842267
TI  - Erratum.
AB  - [This corrects the article on p. 215b in vol. 67.].

PMID- 29842268
TI  - Will It Revert to Pageantry and Burlesque?

PMID- 29842269
TI  - Guy's Hospital: Christmas Decorations.

PMID- 29842270
TI  - The Enlargement of Small Hospitals.

PMID- 29842272
TI  - Health Records of 1918.

PMID- 29842271
TI  - The School Medical Service: Its Educative Possibilities.

PMID- 29842273
TI  - Sir Arbuthnot Lane on Venereal Disease.

PMID- 29842274
TI  - London Hospitals with Medical Schools.

PMID- 29842275
TI  - The Steady Growth of the Voluntary System.

PMID- 29842276
TI  - Hospital and Institutional News.

PMID- 29842278
TI  - At Home-Somewhere in France.

PMID- 29842277
TI  - A Record Distribution: L230,000.

PMID- 29842279
TI  - Report of the Distribution Committee.

PMID- 29842280
TI  - Grants Recommended by the Distribution Committee.

PMID- 29842281
TI  - The Recent Outbreaks and a Great Need.

PMID- 29842282
TI  - London Hospitals without Medical Schools.

PMID- 29842284
TI  - The Administration of Anaesthetics.

PMID- 29842283
TI  - Grants Recommended by the Convalescent Homes Committee.

PMID- 29842286
TI  - Miscellaneous London Hospitals.

PMID- 29842285
TI  - Report of the Convalescent Homes Committee.

PMID- 29842287
TI  - How to Organise the Country.

PMID- 29842288
TI  - Chairmen's Reports of Provincial Hospitals.

PMID- 29842289
TI  - The Nurse's Lack of Business Habits.

PMID- 29842290
TI  - Festival Dinner.

PMID- 29842291
TI  - A Note with a Zoological Interest.

PMID- 29842292
TI  - Round the Hospitals.

PMID- 29842294
TI  - Lord Knutsford's "Impossible."

PMID- 29842293
TI  - The Alternative to State Aid. Local Voluntary Effort.

PMID- 29842296
TI  - Mechanical Disabilities of the Feet: The First of Two Post-Graduate Lectures.

PMID- 29842295
TI  - Medical Aspects of Sterility in Women.

PMID- 29842297
TI  - Army Orders.-September, 1917. Part III.-Nurses Disabled.

PMID- 29842298
TI  - Queen Charlotte's Lying-In Hospital.

PMID- 29842299
TI  - Hospital and Institutional News.

PMID- 29842300
TI  - Which Devour Widows' Houses.

PMID- 29842301
TI  - St. Bartholomew's Hospital.

PMID- 29842303
TI  - The Place of Reading in the Training-School.

PMID- 29842302
TI  - The Kindness Cure.

PMID- 29842304
TI  - The Care of Soldiers' Children.

PMID- 29842305
TI  - Round the Hospitals.

PMID- 29842307
TI  - How a Brighter Outlook Has Been Brought about.

PMID- 29842306
TI  - Certificated Nurses and Trades Unions: A Better and More Effective Alternative.

PMID- 29842308
TI  - The Institutional Worker.

PMID- 29842309
TI  - Demobilisation and Venereal Diseases.

PMID- 29842310
TI  - The Condition Revealed in the Report.

PMID- 29842311
TI  - A Universal Principle Illustrated.

PMID- 29842312
TI  - Mortality among the Insane.

PMID- 29842313
TI  - Tombolas and Their Critics.

PMID- 29842315
TI  - Queen Charlotte's Lying-In Hospital.

PMID- 29842314
TI  - The Editor's Letter-Box.

PMID- 29842316
TI  - Some Considerations in Roofing.

PMID- 29842317
TI  - St. Bartholomew's Hospital.

PMID- 29842318
TI  - Ministry of Health Action and Other Matters.

PMID- 29842319
TI  - Mme. Montessori Speaks for Herself.

PMID- 29842321
TI  - Round the Hospitals.

PMID- 29842320
TI  - A Set of Progressive Needs.

PMID- 29842323
TI  - Pensions for Nurses.

PMID- 29842322
TI  - Hospital and Institutional News.

PMID- 29842324
TI  - The Nursing Club in Dublin.

PMID- 29842325
TI  - The Work of the Medical Branch.

PMID- 29842326
TI  - The Practice of Prevention.

PMID- 29842327
TI  - Old Age and the Thyroid Gland: A Criticism.

PMID- 29842328
TI  - The Quality-Not Quantity-Of the Work.

PMID- 29842330
TI  - The Ministry and Unregistered Dentists.

PMID- 29842329
TI  - Pensions and Gratuities for Disabled Nurses.

PMID- 29842331
TI  - International Health Work.

PMID- 29842333
TI  - Safe Milk.

PMID- 29842332
TI  - Humans or Dogs?

PMID- 29842334
TI  - Comradeship in Hospital Life.

PMID- 29842335
TI  - Annual Meetings of Hospitals.

PMID- 29842336
TI  - Round the Hospitals.

PMID- 29842337
TI  - The Sanitary Blocks of Hospitals.

PMID- 29842338
TI  - Radiography in Hepatic Conditions: A Valuable Aid to Diagnosis.

PMID- 29842339
TI  - Hospital and Institutional News.

PMID- 29842340
TI  - Cleansing the Air.

PMID- 29842341
TI  - The Institutional Worker.

PMID- 29842342
TI  - Contributions from Patients.

PMID- 29842343
TI  - Statement by King Edward's Hospital Fund.

PMID- 29842344
TI  - King Edward's Fund and the London Voluntary Hospitals.

PMID- 29842345
TI  - Care of the Unborn.

PMID- 29842346
TI  - Some Reports of the Work of 1919.

PMID- 29842347
TI  - Scrapping the Trained Nurse.

PMID- 29842348
TI  - The Severer Forms of Laryngitis: Early Diagnosis and Treatment.

PMID- 29842349
TI  - Adopted Children.

PMID- 29842350
TI  - Chronic Intestinal Stasis: New Discoveries in This Disease.

PMID- 29842351
TI  - Rate Aid for Unmarried Mothers.

PMID- 29842352
TI  - The Universities and the Nursing Profession.

PMID- 29842354
TI  - Industrial Medicine.

PMID- 29842353
TI  - Expert Opinion.

PMID- 29842356
TI  - Maesteg and District General Hospital, Maesteg.

PMID- 29842355
TI  - Parliament and the Professions.

PMID- 29842358
TI  - Sheffield and the Red Cross Grant.

PMID- 29842357
TI  - Training Facilities in Little Hospitals.

PMID- 29842360
TI  - Some Points to Be Borne in Mind.

PMID- 29842359
TI  - Food Conditions in Germany: A Situation the World Must Realise.

PMID- 29842362
TI  - Sketches from the Front.

PMID- 29842361
TI  - The L.C.C.'s Employment of Uncertified Nurses.

PMID- 29842363
TI  - Some Landmarks in Flanders: From the Notebooks of a Medical Officer.

PMID- 29842365
TI  - Joint Working of the Two Corporations.

PMID- 29842364
TI  - The College of Nursing and the Minister of Health: Safeguarding the Public
      Interest.

PMID- 29842366
TI  - Joint Women's V.A.D. Department.

PMID- 29842367
TI  - Hospital and Institutional News.

PMID- 29842368
TI  - The Next Influenza Wave.

PMID- 29842369
TI  - The Electro-Chemical Treatment of Seed Grain.

PMID- 29842370
TI  - Woman Workers' World.

PMID- 29842371
TI  - Round the Hospitals.

PMID- 29842373
TI  - With a Garrison Battalion to Africa.

PMID- 29842372
TI  - Members' Conference.

PMID- 29842375
TI  - From across the Seas.

PMID- 29842374
TI  - Queen Charlotte's Hospital.

PMID- 29842377
TI  - Health in Factories.

PMID- 29842376
TI  - Nurse Registration in Victoria.

PMID- 29842379
TI  - Serum Treatment of Pneumonia: Some Experiences and a Forecast.

PMID- 29842378
TI  - Parliament and the Profession.

PMID- 29842380
TI  - The Administration of Anaesthetics.

PMID- 29842381
TI  - Round the Hospitals.

PMID- 29842382
TI  - Not a Produce Broker.

PMID- 29842383
TI  - Hospital and Institutional News.

PMID- 29842384
TI  - Dinner to Dame Sidney Browne, Matron-In-Chief, T.F.N.S.

PMID- 29842385
TI  - Fevers from the East: A Plea for Greater Care and Accuracy.

PMID- 29842386
TI  - Sanatorium Complaints.

PMID- 29842387
TI  - How to Organise the Country.

PMID- 29842388
TI  - The College of Nursing Coat of Arms and Badge.

PMID- 29842389
TI  - This Statement Is Absolutely Untrue!

PMID- 29842390
TI  - A Forty-Eight Hour Week.

PMID- 29842392
TI  - Not Charity but Humanity.

PMID- 29842391
TI  - Some Anti-Plague Measures.

PMID- 29842393
TI  - The Bona Fide Nurse.

PMID- 29842394
TI  - Luncheon to the Uniformed Auxiliary Services.

PMID- 29842395
TI  - Our Dear Ones and Ourselves.

PMID- 29842396
TI  - Is She a Nurse or Not?

PMID- 29842398
TI  - Legal Notes for Institutional Workers.

PMID- 29842397
TI  - The Last Contribution of a Great Authority.

PMID- 29842399
TI  - Sickness among Animals.

PMID- 29842400
TI  - The Wild Women of Mortimer Hall.

PMID- 29842402
TI  - Cottage Benefit Nursing Association.

PMID- 29842401
TI  - After War Conditions.

PMID- 29842404
TI  - Hospital and Institutional News.

PMID- 29842403
TI  - Nurses Unemployed and Underpaid.

PMID- 29842405
TI  - Some Women Who Lost Their Heads.

PMID- 29842406
TI  - Paralytic Deformities and Disabilities of the Feet: The Second of Two Post
      Graduate Lectures.

PMID- 29842408
TI  - Nurses and the Ministry of Health.

PMID- 29842407
TI  - A Treasured Remembrance and Great Opportunity.

PMID- 29842409
TI  - Round the Hospitals.

PMID- 29842410
TI  - The Institutional Worker.

PMID- 29842411
TI  - Inasmuch.

PMID- 29842412
TI  - A Plea for More Frequent Employment.

PMID- 29842413
TI  - Three Years' Training Adopted.

PMID- 29842414
TI  - After-War Developments and Changes.

PMID- 29842415
TI  - Increased Death-Rate in Nervous Disease: A Result of the past Hostilities.

PMID- 29842416
TI  - A Visit to Bethlem Hospital.

PMID- 29842417
TI  - Parliament and the Professions.

PMID- 29842418
TI  - Round the Hospitals.

PMID- 29842419
TI  - Recent Tuberculosis Work.

PMID- 29842420
TI  - London Homoeopathic Hospital.

PMID- 29842421
TI  - Suggestions for a New Policy.

PMID- 29842422
TI  - The Hospital Crisis: A Dangerous Misapprehension.

PMID- 29842423
TI  - Nurses' Remuneration and Justice for All.

PMID- 29842424
TI  - Changes in Staff, Salaries, Departments.

PMID- 29842426
TI  - How the L100,000 Is to Be Distributed.

PMID- 29842425
TI  - Ierne, You May Safely Leave the Woman in the Wards.

PMID- 29842427
TI  - Alcohol and the Human Body: Some Recent Experiments upon Its Action.

PMID- 29842428
TI  - Presentation to a Hospital Engineer.

PMID- 29842429
TI  - Hospital and Institutional News.

PMID- 29842430
TI  - How It Affects the Nurses' Welfare.

PMID- 29842432
TI  - A Recent Lecture Outlined.

PMID- 29842431
TI  - The Institutional Worker.

PMID- 29842434
TI  - The Eight-Hour Day in Private Nursing.

PMID- 29842433
TI  - How to Arrange for Scattered Areas.

PMID- 29842435
TI  - Staff Conditions in Maternity Hospitals.

PMID- 29842436
TI  - The Institutional Worker.

PMID- 29842437
TI  - Round the Hospitals.

PMID- 29842438
TI  - The Nurse Who Thinks.

PMID- 29842440
TI  - Hospital and Institutional News.

PMID- 29842439
TI  - Legal Notes for Institutional Workers.

PMID- 29842442
TI  - Records from Port Sanitary Authority of Liverpool.

PMID- 29842441
TI  - The Victimisation of V.A.D.s.

PMID- 29842444
TI  - A Conflict of Testimony.

PMID- 29842443
TI  - The Editor's Letter-Box.

PMID- 29842445
TI  - The Rates of Tax.

PMID- 29842447
TI  - Some Laws of Health.

PMID- 29842446
TI  - The Doctor and Increased Production.

PMID- 29842449
TI  - Dust.

PMID- 29842448
TI  - The New Era in Teaching.

PMID- 29842450
TI  - Advanced Cases of Tuberculosis: Compulsory Removal Proposed.

PMID- 29842451
TI  - The Institutional Worker.

PMID- 29842453
TI  - Hospital and Institutional News.

PMID- 29842452
TI  - The Meditative Patient.

PMID- 29842455
TI  - The Private Houses of London.

PMID- 29842454
TI  - East Suffolk and Ipswich Hospital Makes Good.

PMID- 29842457
TI  - State Aid or State Advice.

PMID- 29842456
TI  - The District Nurse and the Measles Campaign.

PMID- 29842458
TI  - The Permanent Maintenance of the Voluntary Hospital.

PMID- 29842459
TI  - Red Cross Chairman's Proposal.

PMID- 29842461
TI  - New Quarters in Regent's Park.

PMID- 29842460
TI  - Flying and "Air Sickness."

PMID- 29842463
TI  - Round the Hospitals.

PMID- 29842462
TI  - The Young Man's Opportunity.

PMID- 29842465
TI  - The Problem of Venereal Disease.

PMID- 29842464
TI  - Dr. Addison and the First Council.

PMID- 29842466
TI  - The Nurses' Co-Operation.

PMID- 29842467
TI  - A Happy Vision.

PMID- 29842469
TI  - Receiving the Charge of Governor and President.

PMID- 29842468
TI  - Great Expectations in Durham.

PMID- 29842471
TI  - Association of Certificated Blind Masseurs.

PMID- 29842470
TI  - A Much Underpaid Profession.

PMID- 29842472
TI  - The Best Women in the Kingdom.

PMID- 29842474
TI  - Further "Times" Correspondence.

PMID- 29842473
TI  - The Uniform System of Accounts.

PMID- 29842475
TI  - The College of Nursing and the Nurses' Curriculum.

PMID- 29842476
TI  - Parliament and the Professions.

PMID- 29842478
TI  - Hospitals and the Tax-Payer.

PMID- 29842477
TI  - Census of Health: Tentative Suggestions.

PMID- 29842479
TI  - Hospital and Institutional News.

PMID- 29842480
TI  - Ex-Soldiers and Trade Unions.

PMID- 29842481
TI  - Premier Impressed.

PMID- 29842482
TI  - Red Cross League's Programme.

PMID- 29842484
TI  - The Necessity for Yet Further Extension of Clinics.

PMID- 29842483
TI  - Round the Hospitals.

PMID- 29842486
TI  - Massage.

PMID- 29842485
TI  - The Value of Routine Lumbar Puncture.

PMID- 29842488
TI  - Prices Still Rising.

PMID- 29842487
TI  - The Medical Correspondent.

PMID- 29842490
TI  - County Nursing Associations and Registration.

PMID- 29842489
TI  - Maternity Homes.

PMID- 29842492
TI  - Hospital and Institutional News.

PMID- 29842491
TI  - Temperamental Selection of Institutional Patients.

PMID- 29842493
TI  - Geelong's Thankoffering for Peace.

PMID- 29842494
TI  - Compulsory Registration of Nurses and the Untrained: A Suggestion.

PMID- 29842495
TI  - Round the Hospitals.

PMID- 29842496
TI  - Parliament and the Professions.

PMID- 29842497
TI  - The Campaign against Measles: Effects and Advantages of the New Regulations.

PMID- 29842498
TI  - The Feebleminded.

PMID- 29842499
TI  - Eyes Front!

PMID- 29842501
TI  - Dancing in Relation to the Use of Artificial Legs: A Novel and Interesting
      Development.

PMID- 29842500
TI  - The 48-Hours Bill Applied to Working Nurses.

PMID- 29842502
TI  - The Poor Children's Palace of Desire.

PMID- 29842503
TI  - The Future of Pharmacy.

PMID- 29842504
TI  - The Government and the Voluntary Hospitals.

PMID- 29842505
TI  - The Art of Health Visiting.

PMID- 29842507
TI  - War Conditions in the near East (I.).

PMID- 29842506
TI  - Christmas in the Hospitals.

PMID- 29842509
TI  - The Necessity for Endowing the Nursing Profession.

PMID- 29842508
TI  - Gleanings from the January Issues.

PMID- 29842511
TI  - Milk Improvement.

PMID- 29842510
TI  - Farm Colony Scheme Started.

PMID- 29842512
TI  - Doctors Disagree.

PMID- 29842513
TI  - Some Criticisms Worthy of Attention.

PMID- 29842514
TI  - New Employers' Subscription Scheme in Detail.

PMID- 29842515
TI  - Institutional Needs.

PMID- 29842517
TI  - The Institutional Worker.

PMID- 29842516
TI  - Ideal Homes.

PMID- 29842519
TI  - Large Improvements and Future Outlook.

PMID- 29842518
TI  - A Memorable Ceremony at Guy's Hospital.

PMID- 29842520
TI  - Towards a New Era.

PMID- 29842521
TI  - A Nurses' Club in Dublin.

PMID- 29842523
TI  - Hospital and Institutional News.

PMID- 29842522
TI  - Public Health Offenders.

PMID- 29842525
TI  - Round the Hospitals.

PMID- 29842524
TI  - Plan That Safeguards Healthy Labour.

PMID- 29842526
TI  - Training Colonies.

PMID- 29842527
TI  - The Voluntary Hospitals Made Secure.

PMID- 29842528
TI  - A Valuable Aid to Diphtheria Control?

PMID- 29842529
TI  - National Insurance Medical Benefit Act, 1913, and the Amendment Bill, 1920.

PMID- 29842530
TI  - England, Wales and Scotland Awakening.

PMID- 29842531
TI  - Hospital and Institutional News.

PMID- 29842532
TI  - No Forcible Eviction.

PMID- 29842533
TI  - Children and Cinemas.

PMID- 29842535
TI  - Some Considerations of a Wide Subject.

PMID- 29842534
TI  - The Royal Institute of Public Health.

PMID- 29842536
TI  - Limitations of Common Bacteriological Media.

PMID- 29842537
TI  - Milestones.

PMID- 29842539
TI  - Mothers Who Work.

PMID- 29842538
TI  - Mothercraft Hostels.

PMID- 29842540
TI  - The Association of Surgeons.

PMID- 29842541
TI  - The Ministry's Suggestions.

PMID- 29842542
TI  - The Institutional Worker.

PMID- 29842543
TI  - Round the Hospitals.

PMID- 29842544
TI  - Institutional Needs.

PMID- 29842545
TI  - Women and Emigration.

PMID- 29842546
TI  - Registration and Nursing Reforms.

PMID- 29842547
TI  - Maternity and Child Welfare.

PMID- 29842548
TI  - Home-Helps.

PMID- 29842549
TI  - The Pay of Panel Doctors.

PMID- 29842551
TI  - The First Fruits of Co-Ordination.

PMID- 29842550
TI  - A Mother's Ordeal.

PMID- 29842553
TI  - Cheap Child Labour.

PMID- 29842552
TI  - Sanatoria and Their Critics.

PMID- 29842554
TI  - English and American Children.

PMID- 29842555
TI  - Secrecy in Venereal Diseases.

PMID- 29842556
TI  - Dispensing and Dr. Addison.

PMID- 29842557
TI  - Five Momentous Months: Will the Voluntary Hospitals Be Made Secure?

PMID- 29842558
TI  - King Edward's Hospital Fund for London Statistical Report.

PMID- 29842560
TI  - Influential Plan to Spread Knowledge.

PMID- 29842559
TI  - The Nursery School.

PMID- 29842562
TI  - Food Prices.

PMID- 29842561
TI  - Stage Children.

PMID- 29842564
TI  - Doctors and Patients as Artists See Them.

PMID- 29842563
TI  - The Nursing of Rural Fever Patients.

PMID- 29842566
TI  - Value for Money.

PMID- 29842565
TI  - Nurses' Eight Hours' Work.

PMID- 29842568
TI  - Hospital and Institutional News.

PMID- 29842567
TI  - After-War Crime.

PMID- 29842569
TI  - Sanatorium Results.

PMID- 29842570
TI  - Cardiff Showing the Way.

PMID- 29842572
TI  - The Nurses' Co-Operation.

PMID- 29842571
TI  - Physical Training and the Board of Education.

PMID- 29842573
TI  - Health and Recreation.

PMID- 29842574
TI  - Wages, Hours, and Prices.

PMID- 29842576
TI  - Women and Children Workers.

PMID- 29842575
TI  - Round the Hospitals.

PMID- 29842577
TI  - The British Red Cross and Order of St. John Come to the Help of the Voluntary
      Hospitals.

PMID- 29842578
TI  - A Future English Prospect.

PMID- 29842580
TI  - Health in Factories.

PMID- 29842579
TI  - The St. Andrew's Institute.

PMID- 29842582
TI  - Literary Medicos.

PMID- 29842581
TI  - Surgical Aspects of Spinal Tumours: A Classical Clinical Case.

PMID- 29842583
TI  - Hospital and Institutional News.

PMID- 29842584
TI  - From across the Seas.

PMID- 29842585
TI  - Birth-Rate Problem.

PMID- 29842586
TI  - Psychic Power and Boxing.

PMID- 29842588
TI  - Annual Meeting.

PMID- 29842587
TI  - Health and the Rural Districts.

PMID- 29842589
TI  - Tuberculous Soldiers.

PMID- 29842590
TI  - Psychology in the Nurse's Training.

PMID- 29842591
TI  - The Presentation to Sir E. Cooper Perry: Detailed Report of the Speeches.

PMID- 29842592
TI  - The Friendly Policeman.

PMID- 29842593
TI  - What Every Woman Knows.

PMID- 29842594
TI  - The Salaries of Hospital Officers.

PMID- 29842595
TI  - Church and Social Welfare.

PMID- 29842596
TI  - Round the Hospitals.

PMID- 29842597
TI  - Child Welfare in Birmingham.

PMID- 29842598
TI  - The Educational Possibilities of Brieux's Drama.

PMID- 29842600
TI  - Women Who Are Not Trained Nurses.

PMID- 29842599
TI  - Unemployed Women.

PMID- 29842601
TI  - Training Health Workers.

PMID- 29842602
TI  - City Hospitals as Casualty Stations.

PMID- 29842603
TI  - London County Westminster and Parr's Bank Annual Meeting.

PMID- 29842604
TI  - Excess of Women.

PMID- 29842606
TI  - London Child Labour.

PMID- 29842605
TI  - The Severer Forms of Laryngitis: Early Diagnosis and Treatment.

PMID- 29842607
TI  - Typhus Epidemics: Their Potentialities and Limitations.

PMID- 29842608
TI  - Promotion of Health.

PMID- 29842610
TI  - The Sins of the Fathers.

PMID- 29842609
TI  - The Institutional Worker.

PMID- 29842611
TI  - The House of Charity in Soho.

PMID- 29842612
TI  - New Medical Appeal Boards.

PMID- 29842613
TI  - The Response to Enthusiasm.

PMID- 29842614
TI  - Health and Psychology.

PMID- 29842615
TI  - International Health Bureau.

PMID- 29842616
TI  - War Memories at Winchester.

PMID- 29842618
TI  - The Shortage of Subjects for Anatomical Dissection.

PMID- 29842617
TI  - From the West Suffolk General Hospital, Bury St. Edmund's.

PMID- 29842619
TI  - Child Welfare.

PMID- 29842621
TI  - Round the Hospitals.

PMID- 29842620
TI  - Hospital Accounts.

PMID- 29842623
TI  - Parliament and the Professions.

PMID- 29842622
TI  - The Possibilities Now before Us.

PMID- 29842624
TI  - Unemployment Insurance for Nurses.

PMID- 29842625
TI  - Hospital and Institutional News.

PMID- 29842627
TI  - To Which Mr. H. E. Smithers Replies as Follows.

PMID- 29842626
TI  - Surplus of Women.

PMID- 29842628
TI  - A Practical Demonstration.

PMID- 29842629
TI  - The Uniform System of Accounts.

PMID- 29842631
TI  - Social Work in America.

PMID- 29842630
TI  - Save the Children.

PMID- 29842632
TI  - Nurses' Contributions.-First Instalment.

PMID- 29842633
TI  - The Question of Dairy Produce.

PMID- 29842635
TI  - Alcohol and Infancy.

PMID- 29842634
TI  - A Great National Duty.

PMID- 29842636
TI  - The Push-Button Automatic Lift.

PMID- 29842637
TI  - A Subject of Overwhelming Importance.

PMID- 29842639
TI  - Hospitals and Medical Teaching.

PMID- 29842638
TI  - Better Health Information.

PMID- 29842641
TI  - Some Facts Concerning a "New Disease."

PMID- 29842640
TI  - The Institutional Worker.

PMID- 29842643
TI  - Great Task Ahead.

PMID- 29842642
TI  - Working and Learning.

PMID- 29842644
TI  - Parliament and the Professions.

PMID- 29842645
TI  - Serious Food Aspect.

PMID- 29842646
TI  - "Recommends" for Insured Persons.

PMID- 29842647
TI  - Some Points in Urine Examination.

PMID- 29842648
TI  - Disabled Nurses and Their Dependants.

PMID- 29842649
TI  - The Pessimist Again.

PMID- 29842651
TI  - The Medical Report of the Late L.G.B.: The Last of a Famous Series.

PMID- 29842650
TI  - A Significant Event.

PMID- 29842653
TI  - Round the Hospitals.

PMID- 29842652
TI  - National Physical Education.

PMID- 29842654
TI  - The Collective Interests of Nurses.

PMID- 29842655
TI  - A Much Underpaid Profession.

PMID- 29842656
TI  - Women and the State.

PMID- 29842657
TI  - Hospital and Institutional News.

PMID- 29842658
TI  - Viscount Knutsford on Nurses' Hours.

PMID- 29842660
TI  - War Conditions in the near East--II.

PMID- 29842659
TI  - Serious Financial Problem and Suggested Remedy.

PMID- 29842661
TI  - Twilight Sleep.

PMID- 29842662
TI  - The Nurse and the Nation.

PMID- 29842663
TI  - Legislative Advisers.

PMID- 29842664
TI  - Hospital Annual Meetings.

PMID- 29842666
TI  - National Physical Training: The Outline of a New Scheme.

PMID- 29842665
TI  - Nursing Salaries at Royal Infirmary, Wigan.

PMID- 29842667
TI  - Statistics in Medicine.

PMID- 29842668
TI  - The Staff of Bermondsey Hospital.

PMID- 29842669
TI  - A Hospital Lead.

PMID- 29842670
TI  - Healthy Perturbation.

PMID- 29842671
TI  - The Institutional Worker.

PMID- 29842672
TI  - The New Scheme at King's College Hospital.

PMID- 29842673
TI  - A Much Under-Paid Profession.

PMID- 29842674
TI  - The Possible Remedial Measures.

PMID- 29842675
TI  - Does the Practice of Massage Provide a Livelihood?

PMID- 29842676
TI  - Public Pharmacists' Association.

PMID- 29842677
TI  - Diverticulitis and Its Treatment.

PMID- 29842678
TI  - Health Organisation in Great Towns.

PMID- 29842679
TI  - An Institute of General Pathology and Preventive Medicine.

PMID- 29842680
TI  - Medical or Surgical Treatment for Disabled Nurses.

PMID- 29842681
TI  - The New Nursing Standard for Rate-Supported Institutions.

PMID- 29842682
TI  - Scrapping the Trained Nurse.

PMID- 29842683
TI  - Recognition of Benefactors.

PMID- 29842685
TI  - Unwanted and Illegitimate.

PMID- 29842684
TI  - The Real Lack in Hospital Finance.

PMID- 29842686
TI  - Charity and Commercialism.

PMID- 29842687
TI  - Hospital and Institutional News.

PMID- 29842688
TI  - Round the Hospitals.

PMID- 29842689
TI  - The Adoption of "Summer Time."

PMID- 29842690
TI  - A Further Thyroid "Discovery."

PMID- 29842691
TI  - Other Schemes and Views.

PMID- 29842693
TI  - Is an Absolute Barrier Imposed?

PMID- 29842692
TI  - A Regrettable Misunderstanding.

PMID- 29842695
TI  - Hospital Annual Meetings.

PMID- 29842694
TI  - The King's National Roll.

PMID- 29842696
TI  - Earl Beatty and the Nation's Duty.

PMID- 29842697
TI  - Unveiling the Edith Cavell Memorial: A Beautiful and Memorable Ceremony.

PMID- 29842698
TI  - Cerebro-Spinal Involvement in Hereditary Syphilis.

PMID- 29842699
TI  - Aiding 30,000 Blind.

PMID- 29842700
TI  - More Health Co-Ordination Needed.

PMID- 29842701
TI  - Cleansing Milk.

PMID- 29842702
TI  - Hospital and Institutional News.

PMID- 29842703
TI  - The Prisoners of War Fund and the Hospitals.

PMID- 29842704
TI  - Further Views and Alternatives.

PMID- 29842705
TI  - A Great Match and a Memorable Day.

PMID- 29842707
TI  - The New Nurse.

PMID- 29842706
TI  - The Medical School Gazettes for March.

PMID- 29842708
TI  - Village Centres for the Disabled.

PMID- 29842709
TI  - The Treatment of Sea-Sickness: A New Method and Its Theory.

PMID- 29842710
TI  - Accommodation for Maternity Cases.

PMID- 29842711
TI  - A Factor in Abdominal Disease: Theories and a Remedy.

PMID- 29842712
TI  - Round the Hospitals.

PMID- 29842713
TI  - Report of the General Board for Scotland.

PMID- 29842714
TI  - An Urgent Problem.

PMID- 29842715
TI  - Tobacco Next?

PMID- 29842716
TI  - The Planning of Maternity Hospitals and Homes: Official Notes on Design and
      Organisation.

PMID- 29842717
TI  - Parliament and the Professions.

PMID- 29842718
TI  - King George's Fund for Sailors.

PMID- 29842719
TI  - New Insurance Plans.

PMID- 29842721
TI  - Divorce Law.

PMID- 29842720
TI  - Municipalisation Proposal.

PMID- 29842723
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842722
TI  - The Institutional Worker.

PMID- 29842724
TI  - The Institutional Worker.

PMID- 29842725
TI  - The Institutional Worker.

PMID- 29842726
TI  - Parliament and the Professions.

PMID- 29842727
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842728
TI  - Healthy Physical and Mental Development of Children.

PMID- 29842729
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842731
TI  - The Institutional Worker.

PMID- 29842730
TI  - The National Baby Week Council.

PMID- 29842732
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842733
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842734
TI  - The Institutional Worker.

PMID- 29842735
TI  - Queen Mary's Home for St. Bartholomew's Nurses.

PMID- 29842736
TI  - Passing Events and Topics.

PMID- 29842737
TI  - The Institutional Worker.

PMID- 29842739
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842738
TI  - Invalid and Crippled Children.

PMID- 29842740
TI  - Passing Events and Topics.

PMID- 29842741
TI  - A Nurses' Protest.

PMID- 29842743
TI  - The Institutional Worker.

PMID- 29842742
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842744
TI  - The Institutional Worker.

PMID- 29842745
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842746
TI  - An Interesting Lecture.

PMID- 29842747
TI  - Central Midwives Board for Scotland.

PMID- 29842749
TI  - The Institutional Worker.

PMID- 29842748
TI  - MacCallum v. Burdett and Others.

PMID- 29842750
TI  - Farewell to Wigan Matron.

PMID- 29842751
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842752
TI  - The Institutional Worker.

PMID- 29842753
TI  - The Social Worker in the United States.

PMID- 29842754
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842755
TI  - The Institutional Worker.

PMID- 29842756
TI  - The Institutional Worker.

PMID- 29842757
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842758
TI  - The Institutional Worker.

PMID- 29842759
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842761
TI  - A United Policy in the Coming Elections.

PMID- 29842760
TI  - An Old Friend.

PMID- 29842762
TI  - What the Local Centres Are Doing.

PMID- 29842763
TI  - Provident Scheme for Sussex.

PMID- 29842764
TI  - Erratum: Caveats for Dispensers.
AB  - [This corrects the article on p. 494 in vol. 69.].

PMID- 29842765
TI  - The College of Nursing (Limited by Guarantee).

PMID- 29842766
TI  - The Old Order Changeth.

PMID- 29842767
TI  - A Chairman on the Cave Committee.

PMID- 29842768
TI  - Minimum Salaries Recommended for Fever Nurses.

PMID- 29842769
TI  - The College of Nursing.

PMID- 29842770
TI  - Charing Cross Hospital: Abstract of Clinical Lecture of the Treatment of Empyema.

PMID- 29842771
TI  - Hospital Saturday in London.

PMID- 29842772
TI  - A Year's Work in the Medical Charities of London.

PMID- 29842773
TI  - Taming Radical Pairs in Nanocrystalline Ketones: Photochemical Synthesis of
      Compounds with Vicinal Stereogenic All-Carbon Quaternary Centers.
AB  - Here we describe the use of crystalline ketones to control the fate of the
      radical pair intermediates generated in the Norrish type I photodecarbonylation
      reaction to render it a powerful tool in the challenging synthesis of sterically
      congested carbon-carbon bonds. This methodology makes the synthetically more
      accessible hexasubstituted ketones ideal synthons for the construction of
      adjacent, all-carbon substituted, stereogenic quaternary stereocenters. We
      describe here the structural and thermochemical parameters required of the
      starting ketone in order to react in the solid state. Finally, the scope and
      scalability of the reaction and its application in the total synthesis of two
      natural products is described.

PMID- 29842774
TI  - Catalytic Activation of Trimethylsilylacetylenes: A One-Pot Route to
      Unsymmetrical Acetylenes and Heterocycles.
AB  - For the synthesis of unsymmetrical acetylenes, a Sonogashira coupling
      deprotection-Sonogashira coupling reaction sequence is often used. Removal of
      protecting groups requires harsh conditions or an excess of difficult to handle
      and expensive reagents. Herein, we disclose a novel catalytic method for the
      selective deprotection of trimethylsilylacetylenes in Sonogashira reaction. The
      reagent hexafluorosilicic acid, an inexpensive nontoxic compound, was used to
      promote the selective desilylation. This method enables the efficient synthesis
      of unsymmetric acetylenes with other silylated functional groups present. Further
      possibilities of the method were explored by synthesis of heterocycles.

PMID- 29842775
TI  - Peptide-Programmable Nanoparticle Superstructures with Tailored Electrocatalytic
      Activity.
AB  - Biomaterials derived via programmable supramolecular protein assembly provide a
      viable means of constructing precisely defined structures. Here, we present
      programmed superstructures of AuPt nanoparticles (NPs) on carbon nanotubes (CNTs)
      that exhibit distinct electrocatalytic activities with respect to the
      nanoparticle positions via rationally modulated peptide-mediated assembly. De
      novo designed peptides assemble into six-helix bundles along the CNT axis to form
      a suprahelical structure. Surface cysteine residues of the peptides create AuPt
      specific nucleation site, which allow for precise positioning of NPs onto helical
      geometries, as confirmed by 3-D reconstruction using electron tomography. The
      electrocatalytic model system, i.e., AuPt for oxygen reduction, yields
      electrochemical response signals that reflect the controlled arrangement of NPs
      in the intended assemblies. Our design approach can be expanded to versatile
      fields to build sophisticated functional assemblies.

PMID- 29842776
TI  - Vapor-Phase Synthesis of ZIF-8 MOF Thick Film by Conversion of ZnO Nanorod Array.
AB  - ZIF-8 metal organic framework "micrometer-thick" films were constructed from ZnO
      precursor by a vapor-phase synthesis. The ZnO-to-ZIF-8 crystal transformation
      proceeded in the presence of 2-methylimidazole (Hmim) vapor. Continuous coatings
      of intergrown ZIF-8 crystals require control of a nucleation density. The
      dependence of ZnO crystal plane on the ZnO-to-ZIF-8 crystal transformation was
      investigated using four bulk ZnO single crystals: a-plane (11-20), c-plane
      (0001), m-plane (10-10), and r-plane (10-11). It was revealed that the m-plane
      (10-10) of ZnO is more effectively transformed into ZIF-8. In this work, highly
      oriented ZnO nanorod array film was used to provide the transport pathway of Hmim
      molecules and volume expansion space of ZnO-to-ZIF-8 crystal transformation for
      nucleation and crystal intergrowth. The high conversion of ZnO nanorod array into
      ZIF-8 in a short time could be achieved because (1) such mass transfer is easy
      due to the uniform internanorod distance being maintained during reaction and (2)
      the surface of the nanorod array is dominated by the highly reactive m-plane (10
      10).

PMID- 29842777
TI  - Osmolytes and Protein-Protein Interactions.
AB  - Cells survive fluctuations in osmolality by accumulating and depleting highly
      soluble, usually neutral, small organic compounds. Natural selection has
      converged on a small set of such molecules, called osmolytes. The biophysical
      characterization of osmolytes, with respect to proteins, has centered on tertiary
      structure stability. Data about their effect on protein assemblies, whose
      formation is driven by surface interactions, is lacking. Here, we investigate the
      effects of osmolytes and related molecules on the stabilities of a protein and a
      protein complex. The results demonstrate that osmolytes are not differentiated
      from other cosolutes by their stabilizing influences on protein tertiary
      structure but by their compatibility with the interactions between protein
      surfaces that organize the cellular interior.

PMID- 29842778
TI  - Burn Rate of Calcium Sulfate Dihydrate-Aluminum Thermites.
AB  - The energetics of cast calcium sulfate dihydrate-aluminum thermites were
      investigated. The casts were prepared from water slurries with a solids content
      below 65 wt %. The base case thermite comprised 60 wt % calcium sulfate dihydrate
      as the oxidizer with 40 wt % aluminum as fuel. The heat of hydration of the base
      case was 83 +/- 4 kJ.kg-1 (dihydrate basis) and the initial setting time was
      about 100 min. The compressive strength reached 2.9 +/- 0.2 MPa after 3 days of
      drying in ambient air. The open air burn rate was 12.0 +/- 1.6 mm. s-1 and a
      maximum surface temperature of 1370 +/- 64  degrees C was recorded with a
      pyrometer. Bomb calorimetry indicated an energy output of 8.0 +/- 1.1 MJ.kg-1,
      slightly lower than predicted by the Ekvi thermodynamic simulation. Substitution
      of 10 wt % of the oxidant with copper sulfate pentahydrate significantly
      decreased the initial setting time of the casts to less than 30 min but a
      secondary aluminum oxidation reaction commenced after 2 h. The density of the
      castings was varied by either adding hollow sodium borosilicate microspheres or
      by adding excess water during the casting process. The addition of the hollow
      glass microspheres caused a decrease in the burning rate. Dehydration of the
      casts by thermal treatments at either 155 or 200  degrees C led to significant
      increases in the burning rate.

PMID- 29842779
TI  - Influence of Boron Nitride Nanosheets on the Crystallization and Polymorphism of
      Poly(l-lactide).
AB  - This work reports on the impact of delaminated boron nitride nanosheets (BNNSs)
      on the crystallization behavior and crystalline structure of melt-crystallized
      poly-L-lactic acid (PLLA). Wide-angle X-ray diffraction and scanning electron
      microscopy data revealed that the addition of lower loadings of BNNSs (~0.5 wt %)
      resulted in the highly dispersed PLLA nanocomposites, whereas the higher loading
      of BNNSs (>=1 wt %) leads to the agglomerated nanocomposites. It is shown that
      the presence of lower loadings of the BNNSs (~0.5 wt %) induces the formation of
      ordered alpha form when crystallizing from the melt at a cooling rate of 10 
      degrees C/min, but the mixture of alpha' and alpha forms is formed in the
      presence of higher loading of BNNSs (>=1 wt %). Polarized optical microscopy
      images revealed that the crystallization rate of PLLA was significantly enhanced
      in the presence of lower loading of BNNSs (~0.5 wt %) as corroborated by the
      increasing number of tiny spherulites. The strong interaction between the highly
      dispersed BNNSs and PLLA chains induces the conformationally ordered alpha form,
      and the various experimental techniques revealed that crystallization of PLLA
      occurred rapidly with the narrow distribution of crystal size and degree of
      crystal perfection in highly dispersed nanocomposites. Furthermore, the thermal
      conductivity of PLLA/BNNSs nanocomposites was found to increase significantly
      with BNNSs loading.

PMID- 29842780
TI  - Resistance and Permselectivity of 3D Printed Micropatterned Anion Exchange
      Membranes.
AB  - It has been demonstrated that a micropatterned surface can decrease the
      resistance of anion exchange membranes (AEMs) and can induce desirable flow
      properties in devices, such as mixing. Previously, a model that related the
      resistance of flat and patterned membranes with the same equivalent thickness was
      proposed, which used the patterned area and thickness ratio of the features to
      describe the membrane resistance. Here, we explored the validity of the parallel
      resistance model for a variety of membrane surface designs and area ratios. We
      demonstrated that the model can predict the resistance of a wide range of
      patterned AEMs. We showed that the resistance is independent of the spatial
      ordering of the design by examining random patterns, which is relevant for
      applications that require, for example, increased turbulent liquid flow in
      multilayered devices. Some experimental values of resistance obtained for
      patterned membranes presented deviations from the model. Scanning electron
      microscopy (SEM) images of the patterned membranes revealed resolution variations
      and pattern replication errors due to the stereolithographic process. A geometric
      correction of the target ratios improved the fit of the modelled data to the
      experimental values, showing that light bleeding during curing was a source of
      error. Two additional experimental factors were not accounted for in the model: a
      distinct interface between the bottom and top layer, and overcuring of the bottom
      layer during successive steps. These sources of error were investigated by
      examining the resistance of single and double layered membranes, and single layer
      membranes with different curing times. The differences obtained in the
      resistances for control samples demonstrated that both the interface and
      overcuring influence the resistance of the membrane. The results obtained in this
      study enlighten the discussion relating membrane surface morphology and transport
      properties, as well as the optimization of 3D printed membranes using a
      stereolithography process.

PMID- 29842781
TI  - Microfluidic Low-Input Fluidized-Bed Enabled ChIP-seq Device for Automated and
      Parallel Analysis of Histone Modifications.
AB  - Genome-wide epigenetic changes, such as histone modifications, form a critical
      layer of gene regulations and have been implicated in a number of different
      disorders such as cancer and inflammation. Progress has been made to decrease the
      input required by gold-standard genome-wide profiling tools like chromatin
      immunoprecipitation followed by sequencing (i.e., ChIP-seq) to allow scarce
      primary tissues of a specific type from patients and lab animals to be tested.
      However, there has been practically no effort to rapidly increase the throughput
      of these low-input tools. In this report, we demonstrate LIFE-ChIP-seq (low-input
      fluidized-bed enabled chromatin immunoprecipitation followed by sequencing), an
      automated and high-throughput microfluidic platform capable of running multiple
      sets of ChIP assays on multiple histone marks in as little as 1 h with as few as
      50 cells per assay. Our technology will enable testing of a large number of
      samples and replicates with low-abundance primary samples in the context of
      precision medicine.

PMID- 29842782
TI  - Opal-like Multicolor Appearance of Self-Assembled Photonic Array.
AB  - Molecular self-assembly of short peptide building blocks leads to the formation
      of various material architectures that may possess unique physical properties.
      Recent studies had confirmed the key role of biaromaticity in peptide self
      assembly, with the diphenylalanine (FF) structural family as an archetypal model.
      Another significant direction in the molecular engineering of peptide building
      blocks is the use of fluorenylmethoxycarbonyl (Fmoc) modification, which promotes
      the assembly process and may result in nanostructures with distinctive features
      and macroscopic hydrogel with supramolecular features and nanoscale order. Here,
      we explored the self-assembly of the protected, noncoded fluorenylmethoxycarbonyl
      beta,beta-diphenyl-Ala-OH (Fmoc-Dip) amino acid. This process results in the
      formation of elongated needle-like crystals with notable aromatic continuity. By
      altering the assembly conditions, arrays of spherical particles were formed that
      exhibit strong light scattering. These arrays display vivid coloration, strongly
      resembling the appearance of opal gemstones. However, unlike the Rayleigh
      scattering effect produced by the arrangement of opal, the described optical
      phenomenon is attributed to Mie scattering. Moreover, by controlling the solution
      evaporation rate, i.e., the assembly kinetics, we were able to manipulate the
      resulting coloration. This work demonstrates a bottom-up approach, utilizing self
      assembly of a protected amino acid minimal building block, to create arrays of
      organic, light-scattering colorful surfaces.

PMID- 29842783
TI  - Evidence for Prenucleated Fibrilogenesis of Acid-Mediated Self-Assembling
      Oligopeptides via Molecular Simulation and Fluorescence Correlation Spectroscopy.
AB  - An important step in controlling biomimetic amyloid systems is understanding the
      self-assembly reaction kinetics. We are interested in a family of such materials
      characterized by symmetric sequences of amino acids flanking a pi-conjugated
      functional core. Many of these materials rapidly self-assemble into long fibers
      upon protonation in an acidic environment. Despite extensive investigation of
      these materials' properties, little is yet understood regarding their reaction
      kinetics. Based on previous studies, we have chosen DFAG-4T-GAFD as a
      representative system and conducted molecular dynamics simulations to show that
      although large-scale assembly is induced by lowering pH, some degree of assembly
      is thermodynamically favorable in high-pH nonprotonating environments. These
      results are consistent with findings for other systems such as DFAG-OPV-GAFD. The
      nonprotonated aggregation also appears to be concentration dependent, occurring
      at concentrations of 100 nM and above. Single molecule measurements using
      fluorescence correlation spectroscopy provide experimental support for these
      computational predictions. We find evidence of spontaneous aggregation in aqueous
      solutions of peptides with concentrations as low as 100 nM; however, 10 nM
      solutions appear to be largely homogeneous solutions of unassembled monomer.
      These results indicate that the simplest explanations for kinetics of acid
      mediated assembly-protonation-induced nucleation by monomeric addition followed
      by subsequent stages of aggregation and elongation-are inappropriate in this
      system. In fact, the system only exists as pure monomer in very low
      concentrations, nucleation actually occurs in the absence of protonating elements
      at concentrations typically used for experiments, and pH triggered assembly
      proceeds from these preassembled aggregates. Accordingly, triggered assembly must
      be considered to operate outside the domain of nucleation-dependent models.

PMID- 29842784
TI  - Nanomechanics of Pectin-Linked beta-Lactoglobulin Nanofibril Bundles.
AB  - Nanofibrils of beta-lactoglobulin can be assembled into bundles by site-specific
      noncovalent cross-linking with high-methoxyl pectin (Hettiarachchi et al. Soft
      Matter 2016, 12, 756). Here we characterized the nanomechanical properties of
      bundles using atomic force microscopy and force spectroscopy. Bundles had
      Gaussian cross sections and a mean height of 17.4 +/- 1.4 nm. Persistence lengths
      were calculated using image analysis with the mean-squared end-to-end model. The
      relationship between the persistence length and the thickness had exponents of
      1.69-2.30, which is consistent with previous reports for other fibril types. In
      force spectroscopy experiments, the bundles stretched in a qualitatively
      different manner to fibrils, and some of the force curves were consistent with
      peeling fibrils away from bundles. The flexibility of pectin-linked nanofibril
      bundles is likely to be tunable by modulating the stiffness and length of fibrils
      and the ratio of pectin to fibrils, giving rise to a wide range of structures and
      functionalities.

PMID- 29842785
TI  - Multiplex Lateral Flow Assay for Rapid Visual Blood Group Genotyping.
AB  - Conventional blood group phenotyping by hemagglutination assays, carried out
      pretransfusion, is unsuitable in certain clinical situations. Molecular typing
      offers an alternative method, allowing the deduction of blood group phenotype
      from genotype. However, current methods require a long turnaround time and are
      not performed on-site, limiting their application in emergency situations. Here,
      we report the development of a novel, rapid multiplex molecular method to
      identify seven alleles in three clinically relevant blood group systems (Kidd,
      Duffy, and MNS). Our test, using a dry-reagent allele-specific lateral flow
      biosensor, does not require DNA extraction and allows easy visual determination
      of blood group genotype. Multiplex linear-after-the-exponential (LATE)-PCR and
      lateral flow parameters were optimized with a total processing time of 1 h from
      receiving the blood sample. Our assay had a 100% concordance rate between the
      deduced and the standard serological phenotype in a sample from 108 blood donors,
      showing the accuracy of the test. Owing to its simple handling, the assay can be
      operated by nonskilled health-care professionals. The proposed assay offers the
      potential for the development of other relevant single nucleotide polymorphism
      (SNP) panels for immunohematology and new applications, such as for infectious
      diseases, in the near future.

PMID- 29842786
TI  - Colloidal Stability of Apolar Nanoparticles: The Role of Particle Size and Ligand
      Shell Structure.
AB  - Being able to predict and tune the colloidal stability of nanoparticles is
      essential for a wide range of applications, yet our ability to do so is currently
      poor due to a lack of understanding of how they interact with one another. Here,
      we show that the agglomeration of apolar particles is dominated by either the
      core or the ligand shell depending on the particle size and materials. We do this
      by using small-angle X-ray scattering and molecular dynamics simulations to
      characterize the interaction between hexadecanethiol passivated gold
      nanoparticles in decane solvent. For smaller particles, the agglomeration
      temperature and interparticle spacing are determined by ordering of the ligand
      shell into bundles of aligned ligands that attract one another and interlock. In
      contrast, the agglomeration of larger particles is driven by van der Waals
      attraction between the gold cores, which eventually becomes strong enough to
      compress the ligand shell. Our results provide a microscopic description of the
      forces that determine the colloidal stability of apolar nanoparticles and explain
      why classical colloid theory fails.

PMID- 29842787
TI  - Dimerization of Substituted Arylacetylenes-Quantum Chemical Calculations and
      Kinetic Studies.
AB  - The dimerization of substituted arylacetylenes is a very interesting tool to
      generate 1,3-butadiene 1,4-diradicals. Recently, it was shown that electron
      withdrawing groups attached to the triple bond reduce the activation barrier and
      increase the stability of the diradical intermediates. Here, we investigate the
      influence of the pi donor character of substituents, which are bound to the aryl
      system, on the dimerization reaction of arylacetylenes. Both quantum chemical
      calculations and kinetic studies reveal that the higher the pi donor character of
      substituents, the lower the activation barrier. The highest observed difference
      between the model systems amounts to 4.0 kcal/mol, which represents an
      acceleration by a factor of 700. However, according to the calculations the pi
      donor character of the substituents increases the diradical character of the
      intermediates.

PMID- 29842788
TI  - Thiol Specific and Mitochondria Selective Fluorogenic Benzofurazan Sulfide for
      Live Cell Nonprotein Thiol Imaging and Quantification in Mitochondria.
AB  - Cellular thiols are divided into two major categories: nonprotein thiols (NPSH)
      and protein thiols (PSH). Thiols are unevenly distributed inside the cell and
      compartmentalized in subcellular structures. Most of our knowledge on
      functions/dysfunctions of cellular/subcellular thiols is based on the
      quantification of cellular/subcellular thiols through homogenization of
      cellular/subcellular structures followed by a thiol quantification method. We
      would like to report a thiol-specific mitochondria-selective fluorogenic
      benzofurazan sulfide {7,7'-thiobis( N-rhodamine-benzo[c][1,2,5]oxadiazole-4
      sulfonamide) (TBROS)} that can effectively image and quantify live cell NPSH in
      mitochondria through fluorescence intensity. Limited methods are available for
      imaging thiols in mitochondria in live cells especially in a quantitative manner.
      The thiol specificity of TBROS was demonstrated by its ability to react with
      thiols and inability to react with biologically relevant nucleophilic functional
      groups other than thiols. TBROS, with minimal fluorescence, formed strong
      fluorescent thiol adducts (lambdaex = 550 nm, lambdaem = 580 nm) when reacting
      with NPSH confirming its fluorogenicity. TBROS failed to react with PSH from
      bovine serum albumin and cell homogenate proteins. The high mitochondrial thiol
      selectivity of TBROS was achieved by its mitochondria targeting structure and its
      higher reaction rate with NPSH at mitochondrial pH. Imaging of mitochondrial NPSH
      in live cells was confirmed by two colocalization methods and use of a thiol
      depleting reagent. TBROS effectively imaged NPSH changes in a quantitative manner
      in mitochondria in live cells. The reagent will be a useful tool in exploring
      physiological and pathological roles of mitochondrial thiols.

PMID- 29842789
TI  - Microbial hydroxylation and glycosidation of oleanolic acid by Circinella muscae
      and their anti-inflammatory activities.
AB  - Biotransformation of oleanolic acid (OA) by Circinella muscae AS 3.2695 was
      investigated. Nine hydroxylated and glycosylated metabolites (1-9) were obtained.
      Their structures were elucidated as 3beta,7beta-dihydroxyolean-12-en-28-oic acid
      (1), 3beta,7beta,21beta-trihydroxyolean-12-en-28-oic acid (2),
      3beta,7alpha,21beta-trihydroxyolean-12-en- 28-oic acid (3), 3beta,7beta,15alpha
      trihydroxyolean-12-en-28-oic acid (4), 7beta,15alpha-dihydroxy- 3-oxo-olean-12-en
      28-oic acid (5), 7beta-hydroxy-3-oxo-olean-12-en-28-oic acid (6), oleanolic acid
      28-O-beta-D-glucopyranosyl ester (7), 3beta,21beta-dihydroxyolean-12-en-28- oic
      acid-28-O-beta-D-glucopyranosyl ester (8), and 3beta,7beta,15alpha
      trihydroxyolean-12-en- 28-oic acid-28-O-beta-D-glucopyranosyl ester (9) by
      spectroscopic analysis. Among them, compounds 4 and 9 were new compounds. In
      addition, anti-inflammatory activities were assayed and evaluated for the
      isolated metabolites. Most of the metabolites exhibited significant inhibitory
      activities on lipopolysaccharides-induced NO production in RAW 264.7 cells.

PMID- 29842790
TI  - Mucoadhesive chitosan-coated PLGA nanoparticles for oral delivery of ferulic
      acid.
AB  - This paper describes the development and in vitro evaluation of poly(lactic-co
      glycolic acid) (PLGA) nanoparticles coated with chitosan (CS) for oral delivery
      of ferulic acid (FA). Nanoparticles were obtained by an emulsion evaporation
      technique and characterized. Furthermore, we evaluated the scavenging activity
      over hypochlorous acid (HOCl), the cytotoxicity over tumour cells and the in
      vitro intestinal permeability. Nanoparticles were spherical with a mean diameter
      of 242 nm, positive zeta potential and 50% of encapsulation efficiency. The in
      vitro release in phosphate buffered saline (PBS) (pH 7.4) demonstrated a
      prolonged and biphasic profile diffusion-controlled. In simulated
      gastrointestinal fluids, about 15% of FA was released in gastric fluid and a
      negligible release was observed in the intestinal fluid. In the HOCl scavenging
      activity and cytotoxicity over B16-F10 and HeLa cells, FA-loaded nanoparticles
      presented the same efficacy of the free drug. Besides, in the antioxidant and
      cytotoxic assay, CS contributed to FA effects. In the intestinal permeability
      study, FA-loaded nanoparticles exhibited a permeation of 6% through the Caco-2
      monolayer and 20% through the Caco-2/HT29-MTX/Raji B co-culture. CS-coated PLGA
      nanoparticles are promising carriers for oral delivery of FA.

PMID- 29842791
TI  - Screening for selective anticancer activity of plants from Grazalema Natural
      Park, Spain.
AB  - Since plants are an important source of anticancer drugs, we have carried out a
      random screening for selective anticancer activity of 57 extracts from 45 plants
      collected in Grazalema Natural Park, an area in the South of Spain of high plant
      diversity and endemism. Using lung cancer cells (A549) and lung non-malignant
      cells (MRC-5), we found that several extracts were more cytotoxic and selective
      against the cancer cells than the standard anticancer agent cisplatin. Five
      active extracts were further tested in cancer and normal cell lines from other
      tissues, including three skin cell lines with increasing degree of malignancy. An
      extract from the leaves of Daphne laureola L. (Thymelaeaceae) showed a striking
      potency and selectivity on lung cancer cells and leukemia cells; the IC50 values
      against these cancer cells were approximately 10,000-fold lower than against the
      normal cells. Daphnane-type diterpene orthoesters may be responsible for this
      highly selective anticancer activity.

PMID- 29842792
TI  - Fast and non-derivative method based on high-performance liquid chromatography
      charged aerosol detection for the determination of fatty acids from Agastache
      rugosa (Fisch. et Mey.) O. Ktze. seeds.
AB  - This study utilised response surface methodology to optimise the conditions for
      the extraction of A. rugosa seeds oil (ARO). Single-factor experiment and
      response surface methodology (RSM) were performed to identify the extraction
      time, liquid-solid ratio and extraction temperature that provided the highest
      yield of ARO. The optimal extraction time, liquid-solid ratio and extraction
      temperature were 8 h, 4:1 mL/g and 55  degrees C. The fatty acids (FAs) content
      and oil yield obtained through the optimised impregnation-extraction process were
      19.67 mg/g and 32.1%. These values matched well with the predicted values.
      Linolenic acid was identified to be the main active ingredient of ARO. The high
      performance liquid chromatography-charged aerosol detection method presented here
      is fast and does not require derivatisation. Therefore, it could be used to
      quantitatively analyse the FAs present in ARO and applied to detect compounds
      with low or no ultraviolet response.

PMID- 29842793
TI  - Breast cancer drug trastuzumab induces cardiac toxicity: evaluation of human
      epidermal growth factor receptor 2 as a potential diagnostic and prognostic
      marker.
AB  - Breast cancer is one of the most prevalent forms of cancer in the United States
      and worldwide. Cancer occurs through the uncontrolled development of new abnormal
      cell growth. Clinicians and researchers strive to improve diagnostics and
      treatments in pursuit of remedying breast cancer, while limiting or removing any
      potential side effects that may arise. Unfortunately, traditional treatments,
      such as anthracyclines (i.e., doxorubicin), can damage the cardiovascular system.
      Recent strategies have utilized antibody-based compounds as singular treatments,
      or in conjunction with other treatments, with the aim to minimize side effects.
      The human epidermal growth factor receptor 2 (HER2) protein has been the target
      of numerous antibody-based breast cancer therapies, such as trastuzumab (TZM) and
      trastuzumab emtansine (T-DM1). This review will discuss the HER2 receptor as a
      diagnostic marker in targeting breast cancer using the therapeutic agents TZM and
      T-DM1, as well as discuss the induced cardiac toxicity following TZM and T-DM1
      treatments.

PMID- 29842794
TI  - Evaluation of antioxidant capacity of endemic plant Marrubium astracanicum subsp.
      macrodon: Identification of its phenolic contents by using HPLC-MS/MS.
AB  - Antioxidant properties of Marrubium astracanicum subsp. macrodon solvent extracts
      were measured by both cupric ion reducing antioxidant capacity (CUPRAC) and
      ferric reducing antioxidant power (FRAP) methods. According to the results,
      ethanol extract of the plant has high potential of reducing antioxidant activity
      on CUPRAC method. However, water extract of the plant has lower antioxidant
      potential. Furthermore, both water and ethanol extracts showed lower reducing
      antioxidant activity compare to standards on FRAP method. Moreover, the
      composition and content of plant leaves were detected by UHPLC-ESI-MS/MS. High
      concentrations of quinic acid, p-coumaric acid and malic acid were determined.

PMID- 29842795
TI  - Two new echinocystic acid derivatives catalyzed by filamentous fungus Gliocladium
      roseum CGMCC 3.3657.
AB  - Biotransformation of Echinocystic acid (EA,1) using G. roseum CGMCC 3.3657 has
      been investigated, which leads to the isolation and identification of two novel
      Echinocystic acid derivatives, 4, 16alpha-dihydroxy-3,4-seco-olean-12-en-3,28
      dioic acid (2) and 16alpha-hydroxy, A-homo-3alpha-oxa-olean-12-en-3-one-28-oic
      acid (3). Their structures have been elucidated by analysis of spectroscopic
      data. This biocatalysis could serve as an efficient tool complementary to
      classical chemical methods for the transformation of EA.

PMID- 29842797
TI  - Corrigendum.

PMID- 29842796
TI  - Assessment of the safety and feasibility of 24-hour hospitalization after
      thyroidectomy.
AB  - This study assessed the safety and feasibility of 24-hour hospitalization after
      thyroid surgery. A randomized controlled trial study was performed for 432
      patients scheduled for thyroidectomy in Guangdong General Hospital between
      January 2014 and January 2016. Group A cases (n = 216) were 24-hour hospital stay
      and group B cases (n = 216) were inpatient. Preoperative patient characteristics
      and operative characteristics as well surgical complications were evaluated. Two
      hundred and fourteen patients (99%) of group A were discharged after a 24-hour
      postoperative observation except 1 patient hospitalized 2 days for persistent
      nausea after surgery, and 1 patient who was hospitalized for 2 days for fear of
      the complication after the operation. The complication rates were similar between
      the 2 groups (9/216, 11/216; P > 0.05) and no one was readmitted for operation.
      The overall complication rate of 24-hour hospital stay procedure was low, and
      there were no differences in the rate of complications between these 2 groups.
      Thyroid surgery with 24-hour hospital stay is feasible and safe by experienced
      surgeon in a setting of appropriate facility and management protocol.

PMID- 29842798
TI  - Chemical investigations of male and female leaf extracts from Schinus molle L.
AB  - The pepper-tree Schinus molle is an evergreen ornamental plant with various and
      diversified list of medical uses. In this article we analysed the chemical
      composition of male and female leaves of this plant during the off-flowering and
      flowering seasons. The leaf extracts were obtained by using a sequential
      extraction with solvents of different polarities and the chemical composition was
      investigated by GC-MS. The results showed a total of twenty-three components, in
      which elemol is the most abundant constituent followed by bicyclogermacrene,
      gamma-eudesmol, alpha-eudesmol, beta-eudesmol and isocalamendiol. The petroleum
      ether and diethyl ether extracts from male and female flowering and off-flowering
      leaves consisted of sesquiterpene hydrocarbons as a major constituent followed by
      monoterpene hydrocarbons, while the acetone extracts showed a different
      composition. The obtained results show differences in the chemical composition
      between male and female and flowering and not flowering.

PMID- 29842799
TI  - Exploring the regulatory role of nitric oxide (NO) and the NO-p38MAPK/cGMP
      pathway in larval settlement of the bryozoan Bugula neritina.
AB  - The bryozoan Bugula neritina is a cosmopolitan marine fouling species that causes
      major fouling problems in sub-tropical waters. Settlement of B. neritina larvae
      can be triggered without an obvious external cue. Here, the negative regulatory
      role of nitric oxide (NO) during larval settlement of B. neritina was
      demonstrated to be mediated by cyclic guanosine monophosphate (cGMP). Although
      the regulatory role of the NO-p38 MAPK signaling axis in larval settlement was
      not evident, inhibition of nitric oxide synthase (NOS) led to the deactivation of
      p38 MAPK. Exclusive localization of NO and NO signaling components in sensory
      related organs of the larvae is consistent with its signal transduction function
      in metamorphosis. Overall, this study provides new insights into the regulatory
      roles of the NO-p38MAPK/cGMP pathway in B. neritina settlement.

PMID- 29842800
TI  - Excessive exercise in endurance athletes: Is atrial fibrillation a possible
      consequence?
AB  - Moderate physical activity levels are associated with increased longevity and
      lower risk of atrial fibrillation (AF). However, the relative risk of lone AF is
      3-5-fold higher in intensive endurance-trained athletes compared with healthy
      adults. There is growing concern that "excessive" endurance exercise may promote
      cardiac remodelling, leading to long-term adverse consequences. The pathogenesis
      of exercise-induced AF is thought to arise from an interplay of multiple acute
      and chronic factors, including atrial enlargement, pro-fibrotic tendency, high
      vagal tone, and genotypic profile, which collectively promote adverse atrial
      remodelling. Clinical management of athletes with AF, while challenging, can be
      achieved using various strategies that may allow continued, safe exercise. Based
      on the overall risk-benefit evidence, it is premature to suggest that excessive
      exercise is unsafe or should be curtailed. Evidence-based assessment and
      treatment guidelines are required to ensure optimal and safe exercise among the
      growing number of endurance athletes with AF.

PMID- 29842801
TI  - An update on efflux and uptake transporters as determinants of statin response.
AB  - INTRODUCTION: Statins are used in the treatment of dyslipidemia promoting primary
      and secondary prevention against detrimental cardiovascular events. ATP-binding
      cassette (ABC) and solute carrier (SLC) membrane transporters transport statins
      across the cell membrane. Differences in drug transporter tissue expression and
      activity contribute to variability in statin pharmacokinetics (PK) and response.
      Areas covered: The purpose of this review is to discuss factors impacting
      transporter expression and the effect this has on statin efficacy and safety.
      Previous studies have demonstrated that genetic polymorphisms, drug-drug
      interactions (DDI), nuclear receptors, and microRNAs affect statin PK and
      pharmacodynamics. Expert opinion: Genetic variants of ABCG2 and SLCO1B1
      transporters affect statin PK and, as a result, the intended lipid-lowering
      response. However, the effect size is small, limiting its applicability in
      clinical practice. Furthermore, genetic variants do not totally explain the
      observed intervariability in statin response. Thus, it is likely that
      transcriptional and post-transcriptional regulation of drug transporters are also
      highly involved. Further studies are required to understand the contribution of
      each of these new factors in statin disposition and toxicity.

PMID- 29842802
TI  - How to make handmade bicanalicular silicone ring.

PMID- 29842803
TI  - Clinical evaluation of NIPS for women at advanced maternal age: a multicenter
      retrospective study.
AB  - OBJECTIVE: To explore the clinical effect of noninvasive prenatal screening
      (NIPS) for the women at advanced maternal age (AMA) and discuss the relationship
      between women's age and NIPS effect. METHODS: Fourteen thousand thirty-five women
      at AMA who accepted NIPS from two prenatal diagnosis centers were recruited for
      this study. NIPS were checked by Illumina Next CN 500. All the AMA women received
      prenatal genetic counseling, selected prenatal diagnosis and different clinical
      treatments according to the results of NIPS. RESULTS: A total of 114 cases
      (0.81%) got the NIPS-positive results of T21/T18/T13. One hundred four cases of
      them accepted prenatal diagnosis and 87 cases were proved as true positive. The
      sensitivity, specificity, positive predictive value (PPV) and negative predictive
      value (NPV) were 100, 99.88, 92.55 and 100%, respectively. Seventy-four women
      (0.53%) showed NIPS-positive results of sex chromosomal aneuploidies (SCAs).
      After informed consent, 46 women (62.2%) accepted fetus karyotype analysis.
      Nineteen cases were identified as true positive results, while 27 cases were
      false positive results. The PPV for SCAs in AMA women was 41.3%. The PPV of
      T21/T18/T13 in AMA women over 40 was 100%, while it was 81.91% for the women
      whose age was 35 ~ 40 years old. There was also rising trend in PPV of fetal sex
      chromosome with the increased age (62.50 versus 36.84%). CONCLUSIONS: NIPS is a
      good choice for AMA pregnant women. It can not only achieve satisfactory clinical
      effect, but also greatly reduce invasive prenatal diagnosis. We will get better
      effect of NIPS by further managing AMA women stratified by their age.

PMID- 29842804
TI  - The prevalence and risk factors of visual impairment among rural residents aged
      50 years and above in Yugan county, China.
AB  - PURPOSE: The purpose of the study is to assess the prevalence of visual
      impairment (PVI) among rural residents aged 50 years and above in Yugan county,
      China. Researchers analyzed risk factors and obtained scientific baseline
      information for blindness prevention and control. METHODS: Stratified cluster
      random sampling was used in randomly selecting 5540 rural residents aged >=50 in
      Yugan county. Eligible residents were invited to receive visual acuity
      measurement via ophthalmic examinations. Multivariable logistic regression was
      performed to analyze any risk factors. RESULTS: A total of 5119 rural residents
      participated the ophthalmic examination and investigation. The PVI was 19.2%. The
      prevalence of moderate and severe visual impairment (>=20/400 and <20/60) was
      16.9%, and blindness (<20/400) was 2.27%. Multivariable logistic regression
      showed that age, gender, education, occupation, marital status, drinking
      attitude, dietary habits, amount of sleep, and daily fruit intake were the main
      factors that were most predictive of the PVI. CONCLUSION: The PVI among rural
      residents aged 50 years and above in Yugan county was higher than many other
      districts. Preventive work in Yuan and other local regions should be focused on
      older, separated/divorced, or widowed individuals, and those with a lower level
      of education. Strengthening public awareness consists of educating the public
      about visual health promotion and blindness intervention, including healthy diet
      and healthy habits, which will help to reduce visual impairment of the
      population.

PMID- 29842805
TI  - The MEF2A and MEF2D function as scaffold proteins that interact with HDAC1 or
      p300 in SOD3 expression in THP-1 cells.
AB  - Superoxide dismutase 3 (SOD3) is a SOD isozyme and plays a key role in
      extracellular redox homeostasis. We previously demonstrated that histone
      acetylation is involved in 12-O-tetra-decanoylphorbol-13-acetate (TPA)-elicited
      SOD3 expression in human monocytic THP-1 cells; however, the molecular mechanisms
      responsible for its expression have not yet been elucidated in detail. The
      results of the present study demonstrated that the binding of histone deacetylase
      1 (HDAC1) to the SOD3 promoter region contributed to SOD3 silencing in basal THP
      1 cells. On the other hand, the dissociation of HDAC1 from the SOD3 promoter
      region and the enrichment of p300, a histone acetyltransferase (HAT), within that
      region were observed in TPA-induced THP-1 cells. Myocyte enhancer factor 2 (MEF2)
      functions as a scaffold protein that interacts with histone deacetylases (HDAC)
      or HAT and regulates gene expression. The present results showed that the MEF2A
      and MEF2D function as mediators for TPA-elicited SOD3 expression by interacting
      with HDAC or p300. Additionally, the knockdown of MEF2A or MEF2D in human skin
      fibroblasts suppressed SOD3 expression at the mRNA and protein levels. Our
      results provide an insight into epigenetic regulation of redox gene expression,
      and may ultimately contribute to suppressing the progression of tumours and
      vascular diseases.

PMID- 29842806
TI  - Systematic review and meta-analysis of Spanish studies regarding the association
      between maternal 25-hydroxyvitamin D levels and perinatal outcomes.
AB  - OBJECTIVE: This systematic review and meta-analysis of Spanish studies assessed
      the association of maternal 25-hydroxyvitamin D [25(OH)D] levels on perinatal
      outcomes. METHODS: PubMed, Cochrane Library, Embase, Scielo, Scopus, and Web of
      Science research databases were searched from inception through December 30 2017
      using the terms 'vitamin D', 'pregnancy', and 'Spain'. Studies that compared
      first or second half of pregnancy normal 25(OH)D (>=30.0 ng/mL) versus
      insufficient (20.0-29.9 ng/mL) or deficient (<20.0 ng/mL) circulating levels and
      perinatal outcomes were systematically extracted. Data are presented as pooled
      odds ratios and their 95% confidence intervals (CIs) for categorical variables or
      mean differences and CIs for continuous variables. Risk of bias was evaluated
      with the Newcastle-Ottawa Scale. RESULTS: Five cohort studies met inclusion
      criteria. The risk of gestational diabetes mellitus, preeclampsia, preterm birth,
      and small-for-gestational-age infants, and birthweight was not influenced by
      first half of pregnancy maternal 25(OH)D levels. In addition, second half of
      pregnancy 25(OH) levels did not affect birthweight. CONCLUSION: Maternal 25(OH)D
      levels during pregnancy did not affect studied perinatal outcomes and
      birthweight.

PMID- 29842807
TI  - Dabigatran affects thrombin-dependent platelet aggregation after a week-long
      therapy.
AB  - OBJECTIVE: Dabigatran is a direct thrombin inhibitor. As the main adverse event
      is bleeding, it is relevant whether dabigatran has additional effects on platelet
      function. If so, it could affect the bleeding risk. We aimed to assess in vitro
      aggregation in patients with atrial fibrillation (AF) receiving dabigatran.
      DESIGN: We evaluated 32 AF patients treated with dabigatran (study group) and 18
      non-anticoagulated non-AF blood donors (control group). We assessed light
      transmittance platelet aggregation (LTA) with 100 nmol/L gamma-thrombin in both
      groups. The LTA was performed at two time-points in our dabigatran group of
      patients. RESULTS: The thrombin-induced platelet aggregation was significantly
      lower two hours after dabigatran was taken compared to baseline measurement (9%
      +/- 6% vs. 29% +/- 21%) in our study group. Moreover, we observed that the
      baseline value of platelet aggregation in patients on dabigatran treatment was
      significantly lower compared to healthy volunteers (29% +/- 21% vs. 89 +/- 8).
      However, one subanalysis showed that this significant reduction in platelet
      aggregation at baseline was only observed in patients who received dabigatran for
      over a week. CONCLUSION: The thrombin-induced platelet aggregation is reduced in
      non-valvular AF patients receiving dabigatran after a week-long therapy.

PMID- 29842808
TI  - Social circus program (Cirque du Soleil) promoting social participation of young
      people living with physical disabilities in transition to adulthood: a
      qualitative pilot study.
AB  - PURPOSE: To explore the perceived impact of a social circus program on the
      participation level of young adults' living with physical disabilities from their
      own and their parents' perspective. METHOD: Exploratory phenomenological
      qualitative design. A social circus program was offered for nine months.
      Perceived participation level was documented through pre and post semi-structured
      interviews. A pretested interview guide was used. Interviews were transcribed and
      coded by two independent researchers. RESULTS: The average age of the
      participants (n = 9) was 20.0 +/- 1.4 years with 2/9 being female. Participation
      was perceived as being improved after the intervention from both perspectives
      (participants and parents) mainly for communication, mobility, relationships,
      community life and responsibilities. The intervention was perceived as
      strengthening self-perception and self-efficacy, which in turn enhanced
      participation level and decreased parents' bounding. CONCLUSION: The results show
      promises for social circus as a new approach in adult physical rehabilitation for
      this population in transition.

PMID- 29842809
TI  - Role of granulosa cell mitogen-activated protein kinase 3/1 in gonadotropin
      mediated meiotic resumption from diplotene arrest of mammalian oocytes.
AB  - In mammals, preovulatory oocytes are encircled by several layers of granulosa
      cells (GCs) in follicular microenvironment. These follicular oocytes are arrested
      at diplotene arrest due to high level of cyclic nucleotides from encircling GCs.
      Pituitary gonadotropin acts at the level of encircling GCs and increases
      adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic
      monophosphate (cGMP) and activates mitogen-activated protein kinase 3/1 (MAPK3/1)
      signaling pathway. The MAPK3/1 disrupts the gap junctions between encircling GCs
      and oocyte. The disruption of gap junctions interrupts the transfer of cyclic
      nucleotides to the oocyte that results a drop in intraoocyte cAMP level. A
      transient decrease in oocyte cAMP level triggers maturation promoting factor
      (MPF) destabilization. The destabilized MPF finally triggers meiotic resumption
      from diplotene arrest in follicular oocyte. Thus, MAPK3/1 from GCs origin plays
      important role in gonadotropin-mediated meiotic resumption from diplotene arrest
      in follicular oocyte of mammals.

PMID- 29842810
TI  - Comparing the outcomes of severe versus mild/moderate ptosis using closed
      posterior levator advancement.
AB  - Traditionally, posterior eyelid surgical approaches such as Muller's muscle
      conjunctival resection (MMCR) have been utilised with great success for mild
      cases of ptosis, with external levator approaches having been used for more
      severe cases of ptosis. We present a new technique which we label closed
      posterior levator advancement (CPLA) for the correction of all grades of ptosis.
      This article is a retrospective cohort study reviewing patients with mild,
      moderate, and severe ptosis over a 6-year period, treated by a single surgeon
      using CPLA. Minimum follow-up was 3 months. Patients with good levator function
      (levator palpebrae superioris (LPS) function >10 mm) without concomitant
      procedures were subdivided based on margin-to-reflex-distance-1 (MRD1) into mild
      to-moderate ptosis (MRD1 > 1.5 mm) and severe ptosis (MRD1 <= 1.5 mm) cohorts.
      The outcome measures were preoperative and postoperative MRD1, lid contour,
      intereye symmetry, complications, and revision rates. 393 eyes of 313 patients
      were identified. 91 eyes in the mild-to-moderate cohort had a preoperative MRD1
      of 2.38 mm, and 302 eyes in the severe cohort had a preoperative MRD1 of 0.27 mm.
      Postoperatively, MRD1 was 3.86 mm and 3.49 mm, respectively. There were no
      significant complications in both cohorts, and revision rates were 3.3% (3 of 91
      eyes) in the mild-to-moderate and 2% (6 of 302 eyes) in the severe cohorts. Upper
      eyelid contour was satisfactory in 98.2% of eyes, and 97.5% intereye symmetry
      within 1 mm was observed. Our results show an effective correction of all ptosis
      grades with satisfactory cosmetic outcomes and low complication and revision
      rates.

PMID- 29842811
TI  - Pharmacological treatment options for severe hypertriglyceridemia and familial
      chylomicronemia syndrome.
AB  - INTRODUCTION: A spectrum of disorders, ranging from rare severe cases of
      homozygous null lipoprotein lipase deficiency (LPLD)-familial chylomicronemia
      syndrome (FCS) to heterozygous missense LPLD or polygenic causes, result in
      hypertriglyceridemia and pancreatitis. The effects of mutations are exacerbated
      by environmental factors such as diet, pregnancy, and insulin resistance. Areas
      covered: In this review, authors discuss chronic treatment of FCS by ultra-low
      fat diets allied with the use of fibrates, omega-3 fatty acids, niacin, statins,
      and insulin-sensitizing therapies depending on the extent of residual lipoprotein
      lipase (LPL) activity; novel therapies in development target triglyceride (TG)
      rich lipoprotein particle clearance. Previously, a gene therapy approach to LPL
      alipogene tiparvovec showed that direct targeting of LPL function reduced
      pancreatitis events. An antisense oligonucleotide to apolipoprotein-C3,
      volanesorsen has been shown to decrease TGs by 70-80% and possibly to reduce
      rates of pancreatitis admissions. Studies are underway to validate its long-term
      efficacy and safety. Other approaches investigating the role of LPL modulating
      proteins such as angiopoietin-like petide-3 (ANGPTL3) are under consideration.
      Expert opinion: Current therapeutic options are not sufficient for management of
      many cases of FCS. The availability of antisense anti-apoC3 therapies and, in the
      future, ANGPTL3 therapies may remedy this.

PMID- 29842812
TI  - Management of CHAOS by intact cord resuscitation: case report and literature
      review.
AB  - BACKGROUND: Congenital high airway obstruction syndrome (CHAOS) is a near fatal
      condition, except when the ex utero intrapartum treatment (EXIT) procedure is
      performed as rescue. After antenatal diagnosis of the condition, counseling
      regarding prognosis and outcome needs to be provided. CASE: We describe here a
      case with CHAOS due to isolated fetal laryngeal atresia, presented at our center
      at 33-week gestation. After counseling regarding the uncertain outcome, consent
      for elective caesarean was not given. Intact cord resuscitation (ICR) was done as
      a rescue by a well-coordinated team during delivery. Tracheostomy was performed
      successfully under local anesthesia within five minutes, while the cord was still
      attached to the placenta. The baby had supraglottic stenosis on CT scan.
      Reconstructive surgery is planned after 8 months. The literature review showed 24
      reports of 28 cases with intrinsic airway obstruction managed by EXIT, laryngeal
      atresia was the most common cause (18/28). The outcome was poor in tracheal
      agenesis (1/4 survived) whereas those having laryngeal web or small communication
      (4/4 survived) had better outcome. Tracheal reconstruction was done in 3/28 cases
      only. CONCLUSIONS: The case emphasizes that ICR and tracheostomy during vaginal
      delivery can rescue the baby. The literature reviewed provided insight into the
      outcome of CHAOS cases in world literature.

PMID- 29842813
TI  - Changes in phase-angle under light-dark cycles influenced by nonphotic
      stimulation.
AB  - Most work looking at nonphotic effects on circadian rhythms is conducted when
      animals are held under freerunning conditions, usually constant darkness.
      However, for nonphotic effects to be functionally significant, they should be
      demonstrable under conditions in which most animals live, i.e., a 24-hr light
      dark cycle (LD). Syrian hamsters held in LD 6:18 were administered nonphotic
      stimulation in the form of a 3-hr confinement to a novel wheel starting about 6
      hr before the start of their normal nightly activity bout. This resulted in a 2.5
      hr advance of their activity rhythm on the next day that gradually receded to
      about 1.5 hr over the next 10 days. When hamsters held in LD 6:18 were given five
      novel wheel confinements over 13 days their nightly activity onset advanced 3 hr
      and remained at that phase for at least 2 weeks. Home cage wheel deprivation
      experiments indicated that high levels of home cage activity are necessary to
      maintain the advanced phase. These results show that nonphotic stimulation can
      have large, long-lasting effects on daily rhythms in LD and suggest a possible
      mechanism whereby nocturnal rodents might achieve phase flexibility in response
      to seasonal changes.

PMID- 29842814
TI  - A case report on dermal filler-related periorbital granuloma formation.
AB  - We report a case of a 49-year old East-Asian female who presented with delayed
      onset granuloma formation at the right medial lower eyelid area. The clinical and
      radiologic presentation with pathologic correlation following synthetic
      hyaluronic acid filler injection and its management are described along with a
      review of literature following dermal-filler injections types. Dermal-filler
      related granuloma formation should be included in the differential diagnoses of
      periorbital inflammatory and mass lesions. It is recommended that clinicians who
      perform this procedure should discuss these risks and possible late complications
      with patients and provide them with the relevant product information of the
      injected filler for appropriate management should such early or late
      complications occur.

PMID- 29842815
TI  - Proton range shift analysis on brain pseudo-CT generated from T1 and T2 MR.
AB  - BACKGROUND: In radiotherapy, MR imaging is only used because it has significantly
      better soft tissue contrast than CT, but it lacks electron density information
      needed for dose calculation. This work assesses the feasibility of using pseudo
      CT (pCT) generated from T1w/T2w MR for proton treatment planning, where proton
      range comparisons are performed between standard CT and pCT. MATERIAL AND
      METHODS: MR and CT data from 14 glioblastoma patients were used in this study.
      The pCT was generated by using conversion libraries obtained from tissue
      segmentation and anatomical regioning of the T1w/T2w MR. For each patient, a plan
      consisting of three 18 Gy beams was designed on the pCT, for a total of 42
      analyzed beams. The plan was then transferred onto the CT that represented the
      ground truth. Range shift (RS) between pCT and CT was computed at R80 over 10
      slices. The acceptance threshold for RS was according to clinical guidelines of
      two institutions. A gamma-index test was also performed on the total dose for
      each patient. RESULTS: Mean absolute error and bias for the pCT were 124 +/- 10
      and -16 +/- 26 Hounsfield Units (HU), respectively. The median and interquartile
      range of RS was 0.5 and 1.4 mm, with highest absolute value being 4.4 mm. Of the
      42 beams, 40 showed RS less than the clinical range margin. The two beams with
      larger RS were both in the cranio-caudal direction and had segmentation errors
      due to the partial volume effect, leading to misassignment of the HU.
      CONCLUSIONS: This study showed the feasibility of using T1w and T2w MRI to
      generate a pCT for proton therapy treatment, thus avoiding the use of a planning
      CT and allowing better target definition and possibilities for online adaptive
      therapies. Further improvements of the methodology are still required to improve
      the conversion from MRI intensities to HUs.

PMID- 29842816
TI  - Athletes underestimate sleep quantity during daytime nap opportunities.
AB  - This study examined the difference between athletes' self-reported and objective
      sleep durations during two nap opportunities. Twelve well-trained male soccer
      players' sleep durations were assessed using polysomnography and a self-report
      question during a 60- and 120-min nap opportunity. Participants underestimated
      sleep compared to objective sleep assessments for both the 60-min nap opportunity
      (p = 0.004) and 120-min nap opportunity (p = 0.001). Soccer players
      underestimated their sleep duration by approximately 10 min per hour of nap
      opportunity. It is yet to be determined if athletes are likely to underestimate
      sleep duration during their main nighttime sleep period.

PMID- 29842817
TI  - Factors predicting community participation in patients living with stroke, in the
      Western Cape, South Africa.
AB  - PURPOSE: An important focus of poststroke rehabilitation is the attainment of
      community participation. However, several factors may influence participation
      some of which vary from setting to setting. The aim of this study is to
      investigate the factors influencing community participation among community
      dwelling stroke survivors in the Western Cape, South Africa. MATERIALS AND
      METHODS: The World Health Organization Disability Assessment Schedule 2.0 (WHODAS
      2.0) and the Social Support Questionnaire 6 (SSQ6) were the instruments used to
      collect data. Participant demographics, clinical features and domain-specific
      scores of the WHODAS 2.0 were used as potential predictors. Correlation analysis
      and multiple regression models were used to examine determinants of community
      participation. All assessments were conducted using face-to-face interviews.
      RESULTS: One hundred and six stroke survivors enrolled in this cross-sectional
      study. Risk factors, cognition, mobility, self-care, getting along with people,
      household activities and total WHODAS 2.0 score were associated with
      participation. Four predictors of community participation were identified from
      multiple regression, namely mobility (38%), cognition (11%), life activities (4%)
      and stroke risk factors (1%). Determinants varied by gender and age group.
      Mobility predominated in males and younger adults, while cognition was more
      pronounced in females and the elderly. Lastly, the influence of social support on
      community participation was largely defined by the gender and age of stroke
      survivors. CONCLUSION: The findings suggest focusing stroke rehabilitation on
      important factors such as mobility, cognition, life activities and risk factors
      to advance patients' participation. It also emphasizes giving specific
      consideration to key factors specific for gender and age of stroke survivors.
      Implications for Rehabilitation Community participation in the general population
      of stroke survivors' is largely determined by their mobility function.
      Determinants of community participation among stroke survivors essentially vary
      according to age and gender. Clinically, this study suggests that focusing on
      specific determinants of improved community participation according to stroke
      patients' demographic categories (gender and age) may be an important impetus to
      enhance rehabilitation outcome.

PMID- 29842818
TI  - Selol nanocapsules with a poly(methyl vinyl ether-co-maleic anhydride) shell
      conjugated to doxorubicin for combinatorial chemotherapy against murine breast
      adenocarcinoma in vivo.
AB  - Nanocapsules containing selol and doxorubicin (NCS-DOX) with an oily core of
      selol and a shell of poly(methyl vinyl ether-co-maleic anhydride) covalently
      conjugated to doxorubicin were developed in a previous work. In this study, these
      nanocapsules showed a similar antitumour effect in comparison to the free
      doxorubicin (DOX) treatment, but showed no evident DOX-related cardiotoxicity, as
      evidenced by serum creatine kinase-MB (CK-MB) activity. The histopathological
      analysis showed that the free DOX treatment induced more intense morphological
      damage to myocardial tissues in comparison to NCS-DOX treatment. Animals treated
      with free DOX presented important muscle fibre degradation and animals treated
      with NCS-DOX, heart tissue did not present signals of muscle fibre degeneration.
      These results indicate that the cardiotoxicity related to DOX is reduced when
      this drug is carried by the NCS-DOX. Noteworthy, biodistribution analyses showed
      that NCS-DOX accumulated more intensely in tumours than the free DOX. Thus, this
      study reinforces the importance of the development of nanocapsules as drug
      carriers for the treatment of cancer.

PMID- 29842819
TI  - Investigational cannabinoids in seizure disorders, what have we learned thus far?
AB  - INTRODUCTION: The anticonvulsant activity of cannabinoids attracted much
      attention in the last decade. Cannabinoids that are currently investigated with
      the intention of making them drugs for the treatment of epilepsy are cannabidiol,
      cannabidivarin, Delta9-tetrahydrocannabivarin, and Delta9-tetrahydrocannabinolic
      acid. Areas covered:In this review, the authors look at the results of
      preclinical and clinical studies with investigational cannabinoids. Relevant
      literature was searched for in MEDLINE, SCOPUS, EBSCO, GOOGLE SCHOLAR, and
      SCINDEX databases. Expert opinion: Preclinical studies confirmed anticonvulsant
      activity of cannabidiol and cannabidivarin in a variety of epilepsy models. While
      the results of clinical trials with cannabidivarin are still awaited, cannabidiol
      showed clear therapeutic benefit and good safety in patients with therapy
      resistant seizures associated with Dravet syndrome and in patients with Lennox
      Gastaut syndrome who have drop seizures. However, the full therapeutic potential
      of cannabinoids in treatment-resistant epilepsy needs to be investigated in the
      near future.

PMID- 29842820
TI  - Epidemiological trends of infective endocarditis in a single center in Italy
      between 2003-2015.
AB  - OBJECTIVE: Changes in the incidence, clinical features and microbiology of
      infective endocarditis (IE) observed in a single center in Italy were compared
      between the period 2003-2010 and 2011-2015. METHODS: All cases of IE, defined as
      definite or possible according to the modified Duke criteria, observed at the 'L.
      Sacco' Hospital in Milan, Italy between 2003 and 2015 were retrospectively
      reviewed. RESULTS: 366 episodes of IE were identified in 325 patients. The mean
      number of incident IE over the period 2003-2015 was 1.43 (range: 0.6-2.1) cases
      per 1000 admissions, with a significantly increasing trend from a mean of 1.28
      1.72 cases per 1000 admissions/year in 2003-2010 and 2011-2015, respectively
      (+34%; p = .04). Staphylococci remain the leading pathogens causing IE (29%) with
      a relative increase of methicillin-resistant Staphylococcus aureus between the
      two periods. Streptococci and enterococci account for 26% and 18% of IE,
      respectively. We found an increase in the proportion of cases due to enterococci
      (from 14% in 2003-2010 to 22% in 2011-2015). The rate of in-hospital mortality
      was 19%, similar in the two periods studied. CONCLUSION: The incidence of IE
      continuously increased in our cohort over the past decade and, along with the
      aging of the population, a raise in the incidence of health care-associated
      infections and a change in the distribution of prevalent pathogens were observed.
      Surgery was independently associated with higher in-hospital survival (AOR, 95%
      CI: 0.38, 0.19-0.74; p = .005). A constant surveillance is required to guide the
      optimal management of the changing epidemiology of IE.

PMID- 29842821
TI  - Maternal exposure to endocrine disruptors and placental transmission: a pilot
      study.
AB  - Endocrine disruptors (EDs) are known to affect maternal and child health. The
      objective of our study was to identify the association between some of the most
      important endocrine-disruptive substances (perfluorooctane sulfonate [PFOS],
      perfluorooctanoic acid [PFOA], di2-ethylhexyl-phthalate [DEHP] and mono2
      ethylhexyl-phthalate [MEHP]) and both pregnancy variability and birth outcomes.
      We measured the concentration of the EDs in maternal and cord blood samples of 29
      mother-newborn pairs from the Pertini Hospital in Rome between March and June
      2016. Each mother reported demographic, life style and diet information. We
      compared concentrations of the endocrine disruptors between mother and newborn,
      and among different molecules. We analyzed differences and trends of each ED
      substance according to the demography and diet information. PFOA levels in
      maternal blood showed a negative association with newborn weight. Concentration
      levels of PFOA in both maternal and cord blood of those with physiological
      progression of pregnancy were higher in than in those with pathological
      pregnancies. MEHP trend showed a positive association with maternal age. These
      results confirm the maternal-to-fetus transfer of EDs through the placenta and
      the impact that endocrine disruptors have on pregnancy and birth outcomes.

PMID- 29842822
TI  - Biosynthesized composites of Au-Ag nanoparticles using Trapa peel extract induced
      ROS-mediated p53 independent apoptosis in cancer cells.
AB  - The current study highlights rapid, sustainable, and cost-effective biosynthesis
      of silver (Ag), gold (Au) nanoparticles (NPs), and bimetallic Au-AgNPs composites
      using bio-waste extract of Trapa natans. Growth of the NPs was monitored
      spectrophotometrically and peak was observed at ~525 nm, ~450 nm, and ~495 nm
      corresponding to Plasmon absorbance of AuNPs, AgNPs, and Au-AgNPs, respectively.
      Transmission electron microscopy (TEM) revealed the size of AgNPs (~15 nm), AuNPs
      (~25 nm), and Au-AgNPs (~26-90 nm). Synthesized NPs follow the Gaussian bell
      curve and its crystalline nature was identified by X-ray diffraction (XRD).
      Furthermore, Au-AgNPs induced cytotoxicity in various cancer cells (HCT116, MDA
      MB-231, and HeLa) effectively at 200 MUg/mL. Au-AgNPs-exposed cancer cells
      exhibited apoptotic features such as nuclear condensation, mitochondrial membrane
      potential loss, and cleavage of casp-3 and poly (ADP-ribose) polymerase-1 (PARP).
      Au-AgNPs exposure enhanced reactive oxygen species (ROS) and upon inhibition of
      ROS, apoptosis was reduced effectively. NPs treatment killed HCT116 WT and p53
      knockout cells without any significant difference. Mechanistically, Au-AgNPs
      derived with Trapa peel extract significantly enhance ROS which trigger p53
      independent apoptosis in various cancer cells effectively. Our study explores the
      use of bio-waste for the green synthesis of NPs, which can be attractive
      candidates for cancer therapy.

PMID- 29842823
TI  - Rapid identification of Streptomyces tetracycline producers by MALDI-TOF mass
      spectrometry.
AB  - The main objective of this study was using matrix-assisted laser
      desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for
      assembling of DSM (German Collection of Microorganisms) Streptomyces spectral
      database and identification of wild Streptomyces cultures, which were clustered
      by MALDI-TOF Biotyper OC software as well as for teracycline detection by
      observing of obtained spectra using flexAnalysis software. Production of
      tetracycline was confirmed by thin-layer chromatography. Presence of tetracycline
      mass spectrum was verified by several tetracycline producers (Streptomyces
      aureofaciens LMG 5968, S. aureofaciens 84/25, and S. aureofaciens BMK) and by
      pure tetracycline mass. Our results showed that it is possible to use MALDI-TOF
      MS for identification of tetracycline producers within Streptomyces genera by
      several easy steps. The purpose of this study was to establish cheap and quick
      detection of tetracycline producers.

PMID- 29842824
TI  - Injuries in formal and informal non-professional soccer - an overview of injury
      context, causes, and characteristics.
AB  - The objective of this study is to analyse context, causes, and characteristics of
      injuries in non-professional soccer. Therefore, a retrospective telephone survey
      was carried out with persons who were injured while playing soccer and who
      reported this accident to the Swiss National Accident Insurance Fund (Suva).
      Based on these data, an analysis of 708 soccer injuries was performed. The
      findings show that 30.1% of the injuries occurred during informal soccer play,
      and 75.4% of the injured persons were soccer club members. 53.0% of all injuries
      were caused by contact and 29.5% by foul play. Foul play was not associated with
      injury severity. With respect to injury severity, twisting/turning and being
      tackled by an opponent were identified as the most influental injury causes.
      Moreover, the risk of being severely injured was particularly high players of the
      30+/40+ amateur leagues. In conclusion, the findings highlight that 30+/40+
      league players are a major target group for the prevention of severe soccer
      injuries. Soccer clubs may constitute an appropriate multiplier for implementing
      prevention strategies such as fair play education, healthy play behaviours, and
      prevention programmes. Finally, a better understanding of injury situations
      leading to severe injuries is needed to improve injury prevention.

PMID- 29842825
TI  - Accuracy and precision of loadsol(r) insole force-sensors for the quantification
      of ground reaction force-based biomechanical running parameters.
AB  - Force plates represent the "gold standard" in measuring running kinetics to
      predict performance or to identify the sources of running-related injuries. As
      these measurements are generally limited to laboratory analyses, wireless high
      quality sensors for measuring in the field are needed. This work analysed the
      accuracy and precision of a new wireless insole forcesensor for quantifying
      running-related kinetic parameters. Vertical ground reaction force (GRF) was
      simultaneously measured with pit-mounted force plates (1 kHz) and loadsol(r)
      sensors (100 Hz) under unshod forefoot and rearfoot running-step conditions. GRF
      data collections were repeated four times, each separated by 30 min treadmill
      running, to test influence of extended use. A repeated-measures ANOVA was used to
      identify differences between measurement devices. Additionally, mean bias and
      Bland-Altman limits of agreement (LoA) were calculated. We found a significant
      difference (p < .05) in ground contact time, peak force, and force rate, while
      there was no difference in parameters impulse, time to peak, and negative force
      rate. There was no influence of time point of measurement. The mean bias of
      ground contact time, impulse, peak force, and time to peak ranged between 0.6%
      and 3.4%, demonstrating high accuracy of loadsol(r) devices for these parameters.
      For these same parameters, the LoA analysis showed that 95% of all measurement
      differences between insole and force plate measurements were less than 12%,
      demonstrating high precision of the sensors. However, highly dynamic behaviour of
      GRF, such as force rate, is not yet sufficiently resolved by the insole devices,
      which is likely explained by the low sampling rate.

PMID- 29842826
TI  - Effects of cyclodextrin on the stereoselectivity inhibition of
      acetylcholinesterase by isomalathion.
AB  - In attempt to evaluate the effects of cyclodextrins (CDs) on enantioselectivity
      of chiral pesticides toxicity, this study investigated effects of three kinds of
      cyclodextrins including alpha-CD, beta-CD and randomly methylated beta-CD (RAMEB)
      on toxicity of four enantiomers of isomalathion including (1R, 3R)-isomalathion,
      (1S, 3S)-isomalathion, (1S, 3R)-isomalathion and (1R, 3S)-isomalathion.
      Generally, the addition of alpha-CD and RAMEB (1.5 g/L to 3.5 g/L concentration)
      could lead to reduction of isomalathion toxicity in most cases, while the
      presence of beta-CD (0.3 g/L to 1.5 g/L concentration) enhanced the toxicity of
      isomalathion. It was speculated that higher electronic cloud density and lower
      water solubility of beta-CD than alpha-CD and RAMEB might favor to combination
      between acetylcholinesterase (AChE) and isomalathion included by beta-CD. With
      respect for alpha-CD and RAMEB, isomalathion included by them could be easily
      dissolved in water because of high water solubility of the two CDs. Therefore,
      alpha-CD and RAMEB can be used as remediation regent for the pollution of
      isomalathion, and beta-CD can act as an additive in improving bioactivity of such
      pesticides. In addition, the presence of CDs can alter enantioselectivity of
      chiral pesticides. The differences on the extent of enantioselectivity variation
      of isomalathion induced by alpha-CD, RAMEB and beta-CD might be ascribe to the
      different cavity, electron cloud density and solubility among the three CDs. In
      conclusion, the above results gave researchers a possibility to change
      enantioselectivity of chiral pesticides from undesirable outcomes to desirable
      ones.

PMID- 29842827
TI  - Pesticide binding and urea-induced controlled release applications with
      calixarene naphthalimide molecules by host-guest complexation.
AB  - Three novel calix[4]arene molecule-based 1,8 naphthalimide fluoroionophore for
      the selective determination of kesoxim-methyl were synthesized and used in
      pesticide binding studies. The possible interaction between pesticides and
      fluorescent calix[4]arene molecules was monitored by UV/Vis absorption and
      fluorescence spectroscopy. When compared the studied pesticides, kesoxim-methyl
      was strongly quenched the fluorescence intensity of upper rim-modified
      calix[4]arene. UV and fluorescence titration experiments were also studied to
      determine both the quenching mechanism and stoichiometric ratio consisted in
      complex formation. Furthermore, pesticide release experiments were also performed
      with a fertilizing agent as urea by using fluorescence spectroscopy technique.

PMID- 29842828
TI  - Motivations of South African physicians specialising in public health.
AB  - BACKGROUND: South African physicians can specialise in public health through a
      four-year 'registrar' programme. Despite national health policies that seemingly
      value public health (PH) approaches, the Public Health Medicine (PHM) speciality
      is largely invisible in the health services. Nevertheless, many physicians enrol
      for specialist training. OBJECTIVES: This study investigated physicians'
      motivations for specialising in PHM, their intended career paths, perceptions of
      training, and perspectives about the future of the speciality. METHODS: Focus
      groups and in-depth interviews were conducted with specialists-in-training and
      newly qualified specialists, and thematic analysis of transcripts was performed.
      RESULTS: Motivations, often driven by difficult experiences as young physicians
      in poorly resourced clinical settings, stemmed from a commitment to improving
      communities' health and desire to impact on perceived failing health systems.
      Rather than 'exiting' the South African health service, selecting PHM specialist
      training enacted participants' 'loyalty' to population health. Participants
      anticipated carving out their own careers due to an absence of public sector
      career paths. They believed specialists' contribution centred on providing
      'public health intelligence' - finding and interpreting information; supporting
      services through management and leadership; and inputting into policymaking and
      planning. CONCLUSIONS: Competencies of PHM specialists should be refined to
      inform and improve management of this scarce human resource for health. This is
      particularly important given the proposed major health reforms towards universal
      health coverage in South Africa presently. In addition, findings highlight the
      importance of physicians' early work experiences where avenues for expressing
      'voice', mediated by 'loyalty', could be utilised to improve public sector health
      systems.

PMID- 29842829
TI  - Copper attenuates early and late biochemical alterations induced by inorganic
      mercury in young rats.
AB  - : Mercury (Hg), a divalent metal, produces adverse effects predominantly in the
      renal and central nervous systems. The aim of this study was to determine the
      effectiveness of copper (Cu) in prevention of mercuric mercury (Hg2+)-mediated
      toxic effects as well as the role metallothioneins (MT) play in this protective
      mechanism in young rats. Wistar rats were treated subcutaneously with saline
      (Sal) or CuCl2.2H2O (Cu 2.6 mg/kg/day) from 3 to 7 days old and with saline or
      HgCl2 (Hg 3.7 mg/kg/day) from 8 to 12 days old. The experimental groups were (1)
      Sal-Sal, (2) Cu-Sal, (3) Sal-Hg, and (4) Cu-Hg. MTs and metal contents were
      determined at 13 and 33 days of age. Porphobilinogen synthase (PBG-synthase)
      activity as well as renal and hepatic parameters were measured at 33 days. At 13
      day, Hg2+ exposure increased hepatic MT, Hg, zinc (Zn) and iron (Fe) levels, in
      kidney elevated Cu and Hg and decreased renal Fe concentrations, accompanied by
      elevated blood Hg levels. At 33 days, Hg2+ exposure inhibited renal PBG-synthase
      activity, increased serum urea levels and lowered Fe and Mg levels. Copper
      partially prevented the rise in blood Hg and liver Fe noted at 13 days; and
      completely blocked urea rise and diminished renal PBG-synthase activity
      inhibition at 33 days. In 13-day-old rats, Cu exposure redistributed the Hg in
      the body, decreasing hepatic and blood levels while increasing renal levels,
      accompanied by elevated renal and hepatic MT levels in Hg2+-exposed animals.
      These results suggest that hepatic MT might bind to hepatic and blood Hg for
      transport to the kidney in order to be excreted. ABBREVIATIONS: MT:
      metallothioneins; PBG-synthase: porphobilinogen synthase.

PMID- 29842830
TI  - The key risk indicators of road traffic crashes in Serbia, Nis region.
AB  - Traffic crashes are a serious public health and socio-economic problem, and they
      are one of leading causes of death of males in Serbia. In order to determine the
      main causes of road traffic crashes in Nis region, Republic of Serbia, nine key
      risk indicators of road traffic crashes are identified, organized into four
      groups (number and structure of crashes, consequences of traffic crashes,
      temporal and spatial location of traffic crashes, causes and sanctions), and
      described in detail. The indicators are ranked based on group fuzzy analytic
      hierarchy process (AHP), where experts from insurance companies, professionally
      engaged in the process of risk assessment, with different previous experience
      present different impact on the final ranking. In relation to the most
      influential factors in the assessment of traffic crashes, improper and unadjusted
      vehicle speed, overtaking and passing, as well as the physical condition of the
      driver have the highest effect.

PMID- 29842831
TI  - Response of brain-derived neurotrophic factor to combining cognitive and physical
      exercise.
AB  - PURPOSE: Brain-derived neurotrophic factor (BDNF) is well known for its potential
      to promote brain plasticity. It has been proposed that combining cognitive and
      physical exercise (CCPE) may have the potential to generate more synergistic
      benefits in cognitive function than either cognitive exercise (CE) or physical
      exercise (PE) alone. The purpose of this study was to examine acute responses of
      peripheral BDNF levels and cognitive performance to CE, PE, and CCPE. METHODS:
      Thirteen healthy adult men participated in four experimental sessions; a 30-min
      CE, a 30-min cycling PE at an intensity of 60% peak oxygen uptake, a 30-min CCPE
      at the same intensity as PE, and a 30-min session of complete rest. Plasma BDNF
      levels and cognitive performance were measured before and after each session.
      RESULTS: Both PE and CCPE significantly increased plasma BDNF levels (p < .05).
      CE led to no significant increase (p >= .05), and there was no significant
      difference in peripheral BDNF levels between PE and CCPE (p >= .05). No session
      induced a significant change in cognitive performance (p >= .05). CONCLUSIONS:
      Our study suggests that CE and PE have different responses of peripheral BDNF
      levels and that CCPE had no additional or synergistic effect on peripheral BDNF
      levels compared with PE alone. This study offers further insights into the
      potential mechanisms underlying the respective roles of CE, PE, and CCPE for
      peripheral BDNF levels and cognitive performance.

PMID- 29842832
TI  - Performance of a novel real-time respirator seal integrity monitor on
      firefighters: Simulated workplace pilot study.
AB  - Millions of workers, including firefighters, use respiratory protective device.
      The key aspect in assuring the intended protection level of a respirator is its
      fit. However, even if the respirator originally fits well, the faceseal may be
      breached during its use. Until now, there have been no practically viable,
      inexpensive means to monitor the performance of a respirator during actual use. A
      novel Respirator Seal Integrity Monitor (ReSIM) was developed and recently
      evaluated on manikins by our team. The objective of this study was to evaluate
      the ReSIM effectiveness on respirator-wearing firefighters exposed to aerosols
      while performing simulated routine operational activities. Initially, 15 subjects
      were recruited for the study. Following a preliminary investigation that resulted
      in modifications in the ReSIM prototype and testing protocol, a subset of nine
      firefighters was chosen for a full-scale evaluation. The testing was conducted in
      a 24.3-m3 exposure chamber using NaCl as the challenge aerosol. Controlled
      faceseal leaks were established by opening a solenoid valve for 10, 15, or 20
      sec. Leaks were also established as the tested firefighter slightly repositioned
      the respirator on his/her face. During the testing, the ReSIM measured particles
      inside a full-face elastomeric respirator with a 72.7% leak detection sensitivity
      (probability of correct leak identification) and an 84.2% specificity
      (probability of correct identification of the intervals which are absent of any
      leak). After adjusting for false negatives and persistent false positives,
      sensitivity and specificity increased to 83.6% and 92.2%, respectively. The
      factors causing minor limitations in leak detection sensitivity and specificity
      can be attributed to variability among subjects, moisture's effect on the
      particle sensor, and some in-mask sampling bias. In conclusion, the ReSIM can
      promptly detect the breach in a respirator faceseal with high sensitivity and
      specificity. Due to its capability to alert the wearer of possible overexposure
      to hazardous aerosols, the ReSIM concept has a remarkable potential to be applied
      in various working environments, where respirators are used.

PMID- 29842833
TI  - Eco-friendly approach to the synthesis of silver nanoparticles and their
      antibacterial activity against Staphylococcus spp. and Escherichia coli.
AB  - The aim of this study was to assess bactericidal properties of nanosilver
      obtained with ascorbic acid (vitamin C) as a reducing substance, against
      environmental strains of Gram-positive (Staphylococcus) and Gram-negative
      bacteria (Escherichia coli). Silver nanoparticles were obtained by a simple and
      fast method of chemical reduction in mild synthesis condition using substrates
      not classified as dangerous and commonly found in plants. Bacterial
      susceptibility to nanosilver was determined using the disk-diffusion method. Gram
      positive bacteria were less susceptible to bactericidal action of nanosilver and
      minimum inhibitory concentration was higher for these bacteria. However,
      susceptibility of individual isolates of different species to nanosilver was very
      diverse. The range of growth inhibition zones indicates that the resistance to
      different concentrations of nanosilver was a strain-characteristic, not species
      related feature. The study of effective nanomaterials synthesis and applicability
      appears to be an extremely important element in the development of
      nanotechnology, especially in terms of the risks assessment. Obtained results
      have a real chance to be an important step toward creating a new generation of
      disinfectants without toxic effects on the environment and higher organisms.

PMID- 29842834
TI  - High-Throughput Flow Cytometry Drug Combination Discovery with Novel Synergy
      Analysis Software, SynScreen.
AB  - Classical therapeutic regimens are subject to toxicity, low efficacy, and/or the
      development of drug resistance. Thus, the discovery of synergistic drug
      combinations would permit treatment with lower, tolerable dosages of each agent
      and restored sensitivity. We describe the development and use of the SynScreen
      software application, which allows for visual and mathematical determinations of
      compound concentrations that produce super-additive effects. This software uses
      nonlinear regression fits of dose responses to determine synergism by the Bliss
      independence and Loewe additivity analysis models. We demonstrate the utility of
      SynScreen with data analysis from in vitro high-throughput flow cytometry (HTFC)
      combination screens with repurposed drugs and multiplexed synergy analysis of
      multiple biologic parameters in parallel. The applicability of SynScreen was
      confirmed by testing open-source data sets used in published drug combination
      literature. A key benefit of SynScreen for high-throughput drug combination
      screening is that observed measurements are graphically depicted in comparison
      with a three-dimensional surface that represents the theoretical responses at
      which Bliss additivity would occur. These images and summary tables for the
      calculated drug interactions are automatically exported. This allows for
      substantial data sets to be visually assessed, expediting the quick
      identification of efficacious drug combinations and thereby facilitating the
      design of confirmatory studies and clinical trials.

PMID- 29842835
TI  - Use of Protein Kinase-Focused Compound Libraries for the Discovery of New
      Inositol Phosphate Kinase Inhibitors.
AB  - Inositol hexakisphosphate kinases (IP6Ks) regulate a myriad of cellular
      processes, not only through their catalytic activity (which synthesizes InsP7, a
      multifunctional inositol pyrophosphate signaling molecule) but also through
      protein-protein interactions. To further study the enzymatic function and
      distinguish between these different mechanisms, specific inhibitors that target
      IP6K catalytic activity are required. Only one IP6K inhibitor is commonly used:
      N2-( m-(trifluoromethyl)benzyl) N6-( p-nitrobenzyl)purine (TNP). TNP is, however,
      compromised by weak potency, inability to distinguish between IP6K isoenzymes,
      off-target activities, and poor pharmacokinetic properties. Herein, we describe a
      new inhibitor discovery strategy, based on the high degree of structural
      conservation of the nucleotide-binding sites of IP6Ks and protein kinases; we
      screened for novel IP6K2 inhibitors using a focused set of compounds with
      features known, or computationally predicted, to target nucleotide binding by
      protein kinases. We developed a time-resolved fluorescence resonance energy
      transfer (TR-FRET) assay of adenosine diphosphate (ADP) formation from adenosine
      triphosphate (ATP). Novel hit compounds for IP6K2 were identified and validated
      with dose-response curves and an orthogonal assay. None of these inhibitors
      affected another inositol pyrophosphate kinase, PPIP5K. Our screening strategy
      offers multiple IP6K2 inhibitors for future development and optimization. This
      approach will be applicable to inhibitor discovery campaigns for other inositol
      phosphate kinases.

PMID- 29842836
TI  - Modern dietary guidelines for healthy pregnancy; maximising maternal and foetal
      outcomes and limiting excessive gestational weight gain.
AB  - Maternal dietary habits influence maternal and foetal health, representing a
      pathway for intervention to maximise pregnancy outcomes. Advice on energy intake
      is provided on a trimester basis, with no additional calories required in the
      first trimester and an additional 340 kcal d-1 and 452 kcal d-1 needed for the
      second and third trimesters. Energy intake depends on pre-gravid body mass index
      (BMI); underweight women are recommended an increase of 150, 200 and 300 kcal d-1
      during the first, second and third trimester, normal weight women an increase of
      0, 350 and 500 kcal d-1 and obese women an increase of 0, 450 and 350 kcal day-1.
      The recommendations for carbohydrate and protein intake are 175 g d-1 and 0.88
      1.1 g kgBM d-1, with no change to fat intake. The number of pre-gravid obese
      women is rising; therefore, we need to regulate weight in women of childbearing
      age and limit gestational weight gain to within the recommended ranges
      [overweight women 6.8-11.3 kg and obese women 5.0-9.1 kg]. This can be achieved
      using nutritional interventions, as dietary changes have been shown to help with
      gestational weight management. As pregnancy has been identified as a risk factor
      for the development of obesity, normal weight women should gain 11.5-16.0 kg
      during pregnancy. While some research has shown that dietary interventions help
      to regulate gestational weight gain and promote postpartum weight loss to some
      extent, future research is needed to provide safe and effective guidelines to
      maximise these effects, while benefitting maternal and foetal health.

PMID- 29842837
TI  - Dissipation of terbuthylazine, metolachlor, and mesotrione in soils with
      contrasting texture.
AB  - This study evaluates the dissipation of terbuthylazine, metolachlor, and
      mesotrione at different depths in soils with contrasting texture. The field trial
      was conducted at the Padua University Experimental Farm, north-east Italy. The
      persistence of three herbicides was studied in three different soil textures
      (clay soil, sandy soil, and loamy soil) at two depths (0-5 and 5-15 cm). Soil
      organic carbon content was highest in the clay (1.10%) followed by loam (0.67%)
      and sandy soil (0.24%); the pH of soils was sub-alkaline. Terbuthylazine,
      metolachlor, and mesotrione were applied on maize as a formulated product
      (Lumax(r)) at a dose of 3.5 L ha-1. Their dissipation in the treated plots was
      followed for 2 months after application. The concentrations of herbicides were
      analyzed by liquid chromatography-mass spectrometry. The dissipation of
      terbuthylazine, metolachlor, and mesotrione could be described by a pseudo first
      order kinetics. Terbuthylazine showed the highest DT50, followed by metolachlor
      and mesotrione. Considering the tested soil, the highest DT50 value was found in
      clay soil for terbuthylazine and metolachlor, whereas for mesotrione there was no
      difference among soils. Significant differences were found between the two soil
      depths for terbuthylazine and metolachlor, whereas none were found for
      mesotrione. These results suggest that soil texture and depth have a strong
      influence on the dissipation of terbuthylazine and metolachlor, whereas no
      influence was observed on mesotrione because of its chemical and physical
      properties.

PMID- 29842838
TI  - Laparoscopic salpingectomy and removal of Essure hysteroscopic sterilisation
      device: a case series.
AB  - OBJECTIVES: Tubal sterilisation using Essure is a minimally invasive technique
      for permanent contraception, with high rates of patient satisfaction. However,
      some women subsequently choose removal of the inserts, due to side effects such
      as pelvic pain, abnormal bleeding, dyspareunia or allergic dermatitis. This case
      series presents the management of eight women who underwent laparoscopic removal
      of Essure inserts in conjunction with salpingectomy. We describe our surgical
      technique, its underlying principles and immediate surgical outcomes. METHODS:
      Eight patients were identified as having undergone removal of Essure inserts, via
      an electronic search of the surgical procedures database. A retrospective review
      of case records was undertaken. The primary outcome was safety and feasibility of
      the laparoscopic salpingectomy approach. Secondary outcome measures included
      implant fracture rate, operative time, blood loss and length of patient stay.
      RESULTS: All eight women were able to undergo laparoscopic salpingectomy and
      removal of the Essure inserts without the need for laparotomy or hysterectomy.
      There were no incidences of fracture or incomplete removal of the insert.
      Immediate postoperative recovery was uncomplicated in all eight women; the mean
      length of stay was 17 h. One patient had a small bowel serosal tear attributed to
      laparoscopic entry. CONCLUSION: This case series suggests that laparoscopic
      salpingectomy for removal of Essure inserts is safe and feasible. We acknowledge
      that the numbers were small. However, consistent use of a laparoscopic approach
      in these eight patients indicates that this procedure is a feasible and suitable
      alternative to hysterectomy.

PMID- 29842839
TI  - Effect of Acellular Amniotic Membrane Matrix Patch on Healing of Cut Surface
      After Sleeve Gastrectomy in Rats.
AB  - BACKGROUND: The aim of this study was to evaluate the effect of acellular
      amniotic membrane matrix patch on healing cut surface after sleeve gastrectomy in
      rats. METHODS: Thirty male Wistar albino rats were divided into three groups:
      control (n = 10), Experiment-1 (n = 10), and Experiment-2 (n = 10) groups.
      Control group rats underwent only sleeve gastrectomy with primary gastrorrhaphy.
      Experiment-1 group rats underwent sleeve gastrectomy, primary gastrorrhaphy and
      covered with acellular amniotic membrane matrix patch. Experiment-2 group rats
      underwent sleeve gastrectomy, incomplete primary gastrorrhaphy and covered with
      acellular amniotic membrane matrix patch. All rats were sacrificed on the fifth
      postoperative day. Macroscopic findings and histopathologic alterations were
      evaluated and compared. RESULTS: There was a statistically significant difference
      between levels of PMNs, granulation formation and vascularization, distributions
      of edema, type of mucosal epithelium, and fibroblastic proliferation according to
      groups (p < 0.05). The PMNs level in the Experiment-1 group was significantly
      lower than the control group (p < 0.05). In experiment groups, the level of
      granulation tissue, vascularization and fibroblastic proliferation was
      significantly higher than the control group (p < 0.05). The levels of edema and
      type of mucosal epithelium of the experiment groups were significantly lower than
      the control group (p < 0.05). CONCLUSION: Covering sleeve gastrectomy cut surface
      area with acellular amniotic membrane matrix results better healing. Moreover,
      acellular amniotic membrane matrix provides safe healing even in incomplete
      sutured area.

PMID- 29842840
TI  - Inhibition of di(2-ethylhexyl) phthalate (DEHP)-induced endocrine disruption by
      co-treatment of vitamins C and E and their mechanism of action.
AB  - The endocrine disrupting actions of di(2-ethylhexyl) phthalate (DEHP) on
      testicular functions are postulated to involve excess free radical generation.
      Thus the aim of this study was to examine the ability of antioxidant vitamins C
      and E to prevent DEHP-induced testicular disruption in male Sprague-Dawley (SD)
      rats. SD male rats were administered DEHP alone or DEHP with vitamin C and/or
      vitamin E for 30 days. DEHP alone increased the levels of testosterone (T) and
      reduced estradiol (E2) concentrations. Supplementation with antioxidant vitamins
      diminished or restored serum T levels noted in DEHP-treated rats to control
      values. In contrast vitamins C and E increased E2 levels to control in rats
      administered DEHP. Antioxidants significantly improved the decreased testicular
      levels of reduced glutathione and activity of superoxide dismutase compared to
      DEHP-treatment alone. Co-treatment of vitamins C and E also markedly improved the
      reduced epididymal sperm head counts and elevated levels of malondialdehyde (MDA)
      or 8-hydroxydeoxyguanosine (8-OHdG) induced by DEHP treatment. These results
      support the concept that the adverse actions of DEHP may be related to increased
      free radical generation while co-treatment with vitamins C and E significantly
      blocked the actions of DEHP on male testicular functions.

PMID- 29842841
TI  - Correction to: Georges et al., Quality assessment in Belgian arrhythmology: the
      Belgian heart rhythm association (BeHRA) databases.

PMID- 29842842
TI  - Erratum.

PMID- 29842843
TI  - Interval running with self-selected recovery: Physiology, performance, and
      perception.
AB  - This study (1) compared the physiological responses and performance during a high
      intensity interval training (HIIT) session incorporating externally regulated
      (ER) and self-selected (SS) recovery periods and (2) examined the
      psychophysiological cues underpinning SS recovery durations. Following an
      incremental maximal exercise test to determine maximal aerobic speed (MAS), 14
      recreationally active males completed 2 HIIT sessions on a non-motorised
      treadmill. Participants performed 12 * 30 s running intervals at a target
      intensity of 105% MAS interspersed with 30 s (ER) or SS recovery periods. During
      SS, participants were instructed to provide themselves with sufficient recovery
      to complete all 12 efforts at the required intensity. A semi-structured interview
      was undertaken following the completion of SS. Mean recovery duration was longer
      during SS (51 +/- 15 s) compared to ER (30 +/- 0 s; p < .001; d = 1.46 +/- 0.46).
      Between-interval heart rate recovery was higher (SS: 19 +/- 9 b min-1; ER: 8 +/-
      5 b min-1; p < .001; d = 1.43 +/- 0.43) and absolute time >=90% maximal heart
      rate (HRmax) was lower (SS: 335 +/- 193 s; ER: 433 +/- 147 s; p = .075; d = 0.52
      +/- 0.39) during SS compared to ER. Relative time >=105% MAS was greater during
      SS (90 +/- 6%) compared to ER (74 +/- 20%; p < .01; d = 0.87 +/- 0.40). Different
      sources of afferent information underpinned decision-making during SS. The
      extended durations of recovery during SS resulted in a reduced time >=90% HRmax
      but enhanced time >=105% MAS, compared with ER exercise. Differences in the
      afferent cue utilisation of participants likely explain the large levels of inter
      individual variability observed.

PMID- 29842844
TI  - Anxiety sensitivity cognitive concerns drive the relation between anxiety
      sensitivity and symptoms of depression.
AB  - Depression is typically treated as a homogeneous construct despite evidence for
      distinct cognitive, affective, and somatic symptom dimensions. Anxiety
      sensitivity (AS; the fear of consequences of anxiety symptoms) is a cognitive
      risk factor implicated in the development of depressive symptoms. However, it is
      unclear how lower order AS dimensions (i.e. physical, cognitive, and social
      concerns) relate to depressive symptom factors. Confirmatory factor analysis,
      followed by structural equation modeling, were conducted to examine the factor
      structure of depression and to then examine the relations between these factors
      and the lower order factors of AS. This study was conducted in a sample of 374
      adults (M age = 35.5, 54.3% female) with elevated levels of psychopathology
      (89.2% meeting criteria for at least one DSM-5 diagnosis, 25.6% primary
      depressive disorder). In this study a two-factor model of depression, composed of
      Cognitive and Affective/Somatic factors, was superior to one- and three-factor
      solutions. AS cognitive concerns were related to both cognitive and
      affective/somatic symptoms of depression. Neither of the other AS dimensions was
      related to depression symptom dimensions. These findings provide a better
      understanding of the relations between AS and depression symptoms.

PMID- 29842845
TI  - Portable Systems for Metered Dispensing of Aggressive Liquids.
AB  - Precise metering in liquid dispensing applications often requires application
      specific solutions due to incompatibilities of the sensor and actuator components
      with the dispensed liquids. Some reoccurring challenges are aggressive liquids
      that would damage the sensors or tubing, the need for sterile liquids while the
      pumps or sensors cannot be sterilized, or media that can clog the sensor
      channels. Two different dispensing systems are here presented where the
      dispensing flow rate or volume is indirectly measured through a coupled pressure
      change or airflow, thus avoiding contact between the sensor and liquid. The
      controlled pressure-driven dispensing (cPDD) system builds an overpressure in the
      liquid reservoir by pumping air and controls the opening of the liquid output
      valve based on the internal pressure development. The FlowCap system uses a
      liquid pump on the outlet, controlled by the measured inflow of air to the
      reservoir. Both systems are designed for compactness and portability and offer
      independent operation, as well as control and communication, over a wireless
      interface.

PMID- 29842846
TI  - Metal contents and potential health risk assessment of crops grown in a former
      mining district (Romania).
AB  - The Cd, Cu, Pb and Zn contents in home-grown crops in a former mining district
      were determined in order to evaluate the non-carcinogenic long-term potential
      health risk related to crop consumption. The potential health risk was
      investigated by estimating the daily intake and the hazard quotients. For all
      crop categories, the daily intake and the target hazard quotient were below the
      threshold values for Cd, Cu, and Zn. The daily intake of Pb exceeded the oral
      reference dose, while the target hazard quotient for vegetables was above 1,
      indicating a potential health risk. The total target hazard quotient for the
      individual metals decreased in the following order: Pb>Cd>Cu>Zn. This study
      confirmed that the daily consumption of crops grown in contaminated soils could
      pose health risks to humans.

PMID- 29842847
TI  - Removal of odorous compounds emitted from a food-waste composting facility in
      Korea using a pilot-scale scrubber.
AB  - Monitoring and control of odorous compound emissions have been enforced by the
      Korean government since 2005. One of the point sources for these emissions was
      from food waste composting facilities. In this study, a pilot-scale scrubber
      installed in a composting facility was evaluated for its performance in the
      removal of malodorous compounds. The exhaust stream contained ammonia and
      methylamine as the major odorants detected by the threshold odor test and various
      instrumental techniques (GC-FID, FPD, MS and HPLC/UV). For the scrubber
      operation, the column was randomly packed with polypropylene Hi-Rex 200, while
      aqueous sulfuric acid was selected as the scrubbing solution. To achieve 95%
      removal, the scrubber must be operated by using H2SO4 solution with pH at < 6.5,
      liquid to gas ratio > 4.5, gas loading rate < 1750 m3/m3-hr and contact time <
      0.94 s. The scrubber performance was further evaluated by determining the mass
      transfer coefficients and then monitoring for 355 days of operation. The pilot
      scale scrubber maintained > 95% ammonia and methylamine removal efficiencies
      despite the fluctuations in the inlet (from composting facility exhaust stream)
      concentration. The optimum operating conditions and scrubber performance
      indicators determined in this study provides a basis for the design of a plant
      scale scrubber for treatment of composting facility gas emissions.

PMID- 29842848
TI  - Lactobacillus gasseri PA-3, but not L. gasseri OLL2996, reduces the absorption of
      purine nucleosides in rats.
AB  - Lactobacillus gasseri PA-3 (PA-3) is a bacterial strain with a strong ability to
      degrade purine nucleosides. We previously showed that PA-3 incorporates purines
      in vitro and that oral administration of PA-3 and purines to rats attenuated
      their absorption of purines. It remains unclear whether these effects of PA-3
      depend on bacterial strains. This study therefore compared the abilities of PA-3
      and another bacterial strain of L. gasseri, OLL2996, which has shown decreased
      ability to degrade purine nucleosides in vitro, to incorporate purine nucleosides
      and to inhibit the absorption of purines fed to rats. Each bacterial strain was
      incubated in the presence of 14C-adenosine or 14C-inosine and the incorporation
      of each purine was evaluated by measuring their radioactivity. In vivo, rats were
      fed 14C-labeled purines along with PA-3 or OLL2996 and the absorption of these
      14C-labeled purines was evaluated by analyzing radioactivity of blood samples. PA
      3 incorporated about twice as much 14C-adenosine and 14C-inosine as OLL2996. The
      elevation of radioactivity levels in blood was 10-20% lower in rats treated with
      PA-3 than in control rats, after feeding with both 14C-adenosine and 14C-inosine
      as purines. In contrast, treatment with OLL2996 did not have statistically
      significant effects on radioactivity compared with the control group. These
      results indicate that the magnitude of bacterial inhibition of purine absorption
      is dependent on bacterial strain, correlating at least partly with the ability to
      incorporate and degrade purines.

PMID- 29842849
TI  - Structural insights into pharmacophore-assisted in silico identification of
      protein-protein interaction inhibitors for inhibition of human toll-like receptor
      4 - myeloid differentiation factor-2 (hTLR4-MD-2) complex.
AB  - Toll-like receptor 4 (TLR4) is a member of Toll-Like Receptors (TLRs) family that
      serves as a receptor for bacterial lipopolysaccharide (LPS). TLR4 alone cannot
      recognize LPS without aid of co-receptor myeloid differentiation factor-2 (MD-2).
      Binding of LPS with TLR4 forms a LPS-TLR4-MD-2 complex and directs downstream
      signaling for activation of immune response, inflammation and NF-kappaB
      activation. Activation of TLR4 signaling is associated with various
      pathophysiological consequences. Therefore, targeting protein-protein interaction
      (PPI) in TLR4-MD-2 complex formation could be an attractive therapeutic approach
      for targeting inflammatory disorders. The aim of present study was directed to
      identify small molecule PPI inhibitors (SMPPIIs) using pharmacophore mapping
      based approach of computational drug discovery. Here, we had retrieved the
      information about the hot spot residues and their pharmacophoric features at both
      primary (TLR4-MD-2) and dimerization (MD-2-TLR4*) protein-protein interaction
      interfaces in TLR4-MD-2 homo-dimer complex using in silico methods. Promising
      candidates were identified after virtual screening, which may restrict TLR4-MD-2
      protein-protein interaction. In silico off-target profiling over the virtually
      screened compounds revealed other possible molecular targets. Two of the
      virtually screened compounds (C11 and C15) were predicted to have an inhibitory
      concentration in MUM range after HYDE assessment. Molecular dynamics simulation
      study performed for these two compounds in complex with target protein confirms
      the stability of the complex. After virtual high throughput screening we found
      selective hTLR4-MD-2 inhibitors, which may have therapeutic potential to target
      chronic inflammatory diseases.

PMID- 29842850
TI  - A Single-Step Self-Assembly Approach for the Fabrication of Aligned and
      Multilayered Three-Dimensional Tissue Constructs Using Multidomain Peptide
      Hydrogel.
AB  - Hydrogels are homogenous materials that are limited in their ability to form
      oriented multilayered architecture in three-dimensional (3D) tissue constructs.
      Current techniques have led to advancements in this area. Such techniques often
      require extra devices and/or involve complex processes that are inaccessible to
      many laboratories. Here is described a one-step methodology that permits reliable
      alignment of cells into multiple layers using a self-assembling multidomain
      peptide (MDP) hydrogels. We characterized the structural features, viability, and
      molecular properties of dental pulp cells fabricated with MDP and demonstrated
      that manipulation of the layering of cells in the scaffolds was achieved by
      decreasing the weight by volume percentage (w/v%) of MDP contained within the
      scaffold. This approach allows cells to remodel their environment and enhanced
      various gene expression profiles, such as cell proliferation, angiogenesis, and
      extracellular matrix (ECM) remodeling-related genes. We further validated our
      approach for constructing various architectural configurations of tissues by
      fabricating cells into stratified multilayered and tubular structures. Our
      methodology provides a simple, rapid way to generate 3D tissue constructs with
      multilayered architectures. This method shows great potential to mimic in vivo
      microenvironments for cells and may be of benefit in modeling more complex
      tissues in the field of regenerative medicine.

PMID- 29842851
TI  - Axial mechanical and structural characterization of keratoconus corneas.
AB  - PURPOSE: Previous studies indicate that there is an axial gradient of collagen
      lamellar branching and anastomosing leading to regional differences in corneal
      tissue stiffness that may control corneal shape. To further test this hypothesis
      we have measured the axial material stiffness and quantified the collagen
      lamellar complexity in ectatic and mechanically weakened keratoconus corneas
      (KC). METHODS: Acoustic radiation force elastic microscopy (ARFEM) was used to
      probe the axial mechanical properties of the cone region of three donor KC
      buttons. 3 Dimensional second harmonic generation microscopy (3D-SHG) was used to
      qualitatively evaluate lamellar organization in 3 kC buttons and quantitatively
      measure lamellar branching point density (BPD) in a separate KC button that had
      been treated with epikeratophakia (Epi-KP). RESULTS: The mean elastic modulus for
      the KC corneas was 1.67 +/- 0.44 kPa anteriorly and 0.970 +/- 0.30 kPa
      posteriorly, substantially below that previously measured for normal human
      cornea. 3D-SHG of KC buttons showed a simplified collagen lamellar structure
      lacking noticeable angled lamellae in the region of the cone. BPD in the
      anterior, posterior, central and paracentral regions of the KC cornea were
      significantly lower than in the overlying Epi-KP lenticule. Additionally, BPD in
      the cone region was significantly lower than the adjacent paracentral region in
      the KC button. CONCLUSIONS: The KC cornea exhibits an axial gradient of
      mechanical stiffness and a BPD that appears substantially lower in the cone
      region compared to normal cornea. The findings reinforce the hypothesis that
      collagen architecture may control corneal mechanical stiffness and hence corneal
      shape.

PMID- 29842852
TI  - The modifying effect of kidney function on the association of cadmium exposure
      with blood pressure and cardiovascular mortality: NHANES 1999-2010.
AB  - OBJECTIVE: We hypothesized that the associations of urinary Cd with blood
      pressure and cardiovascular disease (CVD) mortality may be modified by renal
      function. METHODS: We tested these hypotheses using data from the National Health
      and Nutrition Examination Survey (NHANES, 1999-2010). RESULTS: Both systolic
      blood pressure (SBP) and diastolic blood pressure (DBP) were positively
      associated with blood Cd. DBP was positively related to urinary Cd whereas SBP
      was inversely associated with urinary Cd. In the stratified analyses by level of
      eGFR, the associations between SBP and urinary Cd were not statistically
      significant among those with normal renal function and those with mildly reduced
      renal function whereas SBP significantly positively associated with urinary Cd
      among those with moderately or severely decreased renal function (p for trend,
      0.0004). Renal function appeared to be a modifying factor of the association
      between urinary Cd and mortality. CVD mortality risks (p for trend, 0.04) were
      significantly increased with increasing urinary Cd with hazard ratios (HRs) (95%
      CIs) of 2.18 (0.68-7.01) for the highest quartile of urinary Cd compared to the
      lowest. The association between urinary Cd and CVD mortality became stronger in
      the stratified analyses by renal function and these associations became more
      consistent in those who never smoked. CONCLUSIONS: The inverse association
      between urinary Cd and blood pressure observed in previous studies may be due to
      lack of consideration of renal function as an effect modifier. The strength of
      the association between urinary Cd and CVD mortality may be underestimated
      without considering renal function.

PMID- 29842853
TI  - Reproducible model development in the cardiac electrophysiology Web Lab.
AB  - The modelling of the electrophysiology of cardiac cells is one of the most mature
      areas of systems biology. This extended concentration of research effort brings
      with it new challenges, foremost among which is that of choosing which of these
      models is most suitable for addressing a particular scientific question. In a
      previous paper, we presented our initial work in developing an online resource
      for the characterisation and comparison of electrophysiological cell models in a
      wide range of experimental scenarios. In that work, we described how we had
      developed a novel protocol language that allowed us to separate the details of
      the mathematical model (the majority of cardiac cell models take the form of
      ordinary differential equations) from the experimental protocol being simulated.
      We developed a fully-open online repository (which we termed the Cardiac
      Electrophysiology Web Lab) which allows users to store and compare the results of
      applying the same experimental protocol to competing models. In the current paper
      we describe the most recent and planned extensions of this work, focused on
      supporting the process of model building from experimental data. We outline the
      necessary work to develop a machine-readable language to describe the process of
      inferring parameters from wet lab datasets, and illustrate our approach through a
      detailed example of fitting a model of the hERG channel using experimental data.
      We conclude by discussing the future challenges in making further progress in
      this domain towards our goal of facilitating a fully reproducible approach to the
      development of cardiac cell models.

PMID- 29842854
TI  - Repeated weight cycling in obese mice causes increased appetite and glucose
      intolerance.
AB  - Obesity is an ongoing global public health problem. For many people dieting is
      the preferred method of combating elevated body fat. Weight lost during caloric
      restriction is often soon regained and so a pattern of recurrent dieting
      develops. Here an individual's food intake fluctuates up and down with
      intermittent periods of normal eating and restrained eating. The metabolic
      consequences of 'yoyo dieting' or 'weight cycling' are not well understood. Here
      we monitor the effects of multiple, repeated dieting periods on body composition
      and metabolic health in overweight mice. Compared to mice that were continuously
      fed a high fat diet, the energy expenditure of diet-cycled mice was reduced. This
      resulted in mice rapidly regaining body weight upon the reintroduction of high
      fat chow diet subsequent to periods of caloric restriction. Diet cycling also
      increased the appetite for high fat chow and diminished glucose tolerance. These
      data demonstrate the detrimental effects of diet cycling upon metabolic health.

PMID- 29842855
TI  - The benefits of social buffering are maintained regardless of the stress level of
      the subject rat and enhanced by more conspecifics.
AB  - Social buffering is a phenomenon in which the presence of an affiliative
      conspecific (associate) mitigates stress responses in a subject. We assessed the
      relationship between the stress level of subjects and the benefit of social
      buffering. In Experiment 1, subjects fear-conditioned using 0.15-mA, 0.45-mA, or
      0.70-mA foot shocks were re-exposed to a conditioned stimulus (CS) either alone
      or with an associate on the day following fear conditioning. We found that
      behavioral responses were reduced by the presence of an associate. The intensity
      of this decrease was similar among all subjects. These results suggest that the
      intensity of social buffering was similar regardless of the stress level of the
      subject. The high stress subjects showed residual stress responses after
      receiving social buffering, indicating that the residual stress responses may
      have been resistant to social buffering. To further examine this, subjects fear
      conditioned using 0.70-mA foot shocks were re-exposed to the CS either alone,
      with one associate, or with three associates in Experiment 2. We found that
      behavioral responses decreased as the number of associates increased. These
      results suggest that residual stress responses are further ameliorated when the
      number of associates increases. Therefore, the residual stress responses were
      also sensitive to buffering. Taken together, our data indicate that the benefits
      of social buffering are maintained regardless of the stress level of the subject
      rat and enhanced by more conspecifics.

PMID- 29842856
TI  - The first-trimester maternal serum cyclophilin A concentrations in women with
      complicated pregnancy as preeeclampsia.
AB  - BACKGROUND: Cyclophilin A (CyPA) is a potential mediator of inflammation. We
      assessed the predictive value of the first-trimester maternal serum CyPA
      concentrations for complicated pregnancy. METHODS: The first-trimester serum CyPA
      concentrations were quantified in 100 women with normal pregnancy and in 351
      women with complicated pregnancy, including 102 pre-eclampsia women, 131
      gestational hypertension (GH) women and 118 gestational diabetes mellitus (GDM)
      women. Its association with complicated pregnancy was ascertained using
      multivariate analysis. RESULTS: Median CyPA concentrations were significantly
      higher in women developing complicated pregnancy as pre-eclampsia, GH or GDM than
      in women with normal pregnancy. CyPA concentrations were independently correlated
      with C-reactive protein concentrations in complicated pregnancy as pre-eclampsia,
      GH or GDM women. Serum CyPA and body mass index were independently associated
      with the development of complicated pregnancy as pre-eclampsia, GH or GDM. Serum
      CyPA possessed significantly high area under receiver operating characteristic
      curve. Meanwhile, CyPA significantly improved the predictive value of body mass
      index. CONCLUSIONS: Serum CyPA might be utilized as a potential inflammatory
      biomarker for complicated pregnancy and assessment of serum CyPA might aid in the
      prediction of complicated pregnancy.

PMID- 29842857
TI  - Plasma concentration of diamine oxidase (DAO) predicts 1-month mortality of acute
      on-chronic hepatitis B liver failure.
AB  - BACKGROUND: Acute-on-chronic hepatitis B liver failure (ACHBLF) has high 1-month
      mortality but it is difficult to predict. This present study was aimed to
      determine the diagnostic value of plasma diamine oxidase (DAO) in predicting the
      1-month mortality of ACHBLF. METHODS: A total of 106 consecutive newly diagnosed
      ACHBLF patients were retrospectively collected. The plasma expression of DAO was
      determined using enzyme-linked immunosorbent assay (ELISA). RESULTS: The plasma
      DAO level of survivals [14.0 (7.1; 26.5) ng/mL] was significantly lower than the
      nonsurvivals [58.6 (32.5; 121.3) ng/mL, P < .001]. The plasma DAO level, hepatic
      encephalopathy, spontaneous bacterial peritonitis and model for end-stage liver
      disease (MELD) score were independent factors associated with the 1-month
      mortality for ACHBLF. The cut-off point of 15.2 ng/mL for plasma DAO level with
      sensitivity of 95.45%, specificity of 62.5%, 22.6 for MELD score with sensitivity
      of 90.91%, specificity of 67.5%, 0.07 for DAO plus MELD with sensitivity of
      87.88%, specificity of 80% were selected to discriminate 1-month morality of
      ACHBLF. Furthermore, DAO plus MELD score showed high AUROC than MELD score for
      predicting 1-month (0.916 vs. 0.843, P < .01). CONCLUSIONS: The plasma DAO level
      plus MELD > 0.07 predicts poor 1-month mortality of ACHBLF.

PMID- 29842858
TI  - Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory
      consolidation in rats through CB2 receptor activation and mTOR signaling
      modulation.
AB  - The endocannabinoid system is a key modulator of memory consolidation for
      aversive experiences. We recently found that the fatty acid amide hydrolase
      (FAAH) inhibitor URB597, which increases anandamide levels by inhibiting its
      hydrolysis, facilitates memory consolidation through a concurrent activation of
      both cannabinoid receptor type 1 (CB1) and 2 (CB2). Here, we investigated the
      role played on memory consolidation by the other major endocannabinoid, 2
      arachidonoylglycerol (2-AG). To this aim, we tested the effects of
      pharmacological inhibition of monoacylglycerol lipase (MAGL) through systemic
      administration of the MAGL inhibitor JZL184 to rats immediately after training of
      the inhibitory avoidance task. Pharmacological enhancement of 2-AG tone
      facilitated memory consolidation through activation of CB2 receptor signaling.
      Moreover, we found that increased 2-AG signaling prevented the activation of the
      mammalian target of rapamycin (mTOR) signaling pathway in the hippocampus through
      a CB2-dependent mechanism. Our results identify a fundamental role for 2-AG and
      CB2 receptors in the modulation of memory consolidation for aversive experiences.

PMID- 29842859
TI  - I must have missed that: Alpha-band oscillations track attention to spoken
      language.
AB  - Attention is critical to the construction of mental representations of language
      context during comprehension. We investigated the consequences of momentary
      lapses in attention during listening comprehension on neural activity and
      behavior. Participants listened to two full-length stories while EEG was
      recorded, and afterwards completed multiple choice comprehension questions.
      Listening was periodically interrupted by attention probes, in which participants
      were asked whether their attention immediately preceding the probe's appearance
      was focused on the story. The results showed that (1) participants spent a
      substantial amount of time off-task, endorsing attention lapses on over 30% of
      probes; (2) for probes on which an attention lapse was endorsed, later accuracy
      on comprehension questions querying pre-probe information was decreased; (3) the
      pre-probe period just before the endorsement of an attention lapse was
      characterized by a greater percentage of above-threshold oscillations in the
      alpha-band (8-12 Hz) compared to just prior to the endorsement of on-task or
      split-attention listening; and (4) when participants made "I have no idea"
      responses to comprehension questions, their EEG record revealed a greater
      percentage of above-threshold alpha oscillations during the original presentation
      of the information queried by the comprehension questions, compared to correct
      responses or incorrect guesses. These results connect changes in neural activity
      in the alpha band to episodes of mind-wandering during listening comprehension,
      and in turn to decreased comprehension accuracy. This demonstrates how alpha can
      be used to track attentional engagement during language comprehension, and
      illustrates the dependence of successful language comprehension on attention.

PMID- 29842860
TI  - Dexmedetomidine attenuated early brain injury in rats with subarachnoid
      haemorrhage by suppressing the inflammatory response: The TLR4/NF-kappaB pathway
      and the NLRP3 inflammasome may be involved in the mechanism.
AB  - Early brain injury (EBI) plays a pivotal role in the prognosis of patients with
      subarachnoid haemorrhage (SAH). Dexmedetomidine (DEX), a highly selective alpha2
      receptor agonist, is reported to exert multiple protective effects in many
      neurological diseases. This study was designed to investigate whether DEX had
      neuroprotective functions in EBI after SAH, and to explore the possible
      mechanisms. The SAH model was established by an endovascular perforation in adult
      male Sprague-Dawley (SD) rats. DEX (25 ug/kg) or vehicle was administered
      intraperitoneally 2 h after SAH. Neurological deficits, brain oedema,
      inflammation, BBB damage, and cell apoptosis at 24 h after SAH were evaluated.
      Additionally, the expression of components of the Toll-like receptor 4
      (TLR4)/nuclear factor-kappaB (NF-kappaB) pathway, and the nucleotide-binding
      oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3)
      inflammasome were also assessed. We demonstrated that DEX treatment improved
      neurological scores, alleviated brain oedema, reduced the permeability of the
      blood-brain barrier (BBB), and up-regulated the expression of tight junction
      proteins. DEX treatment could reduce the neutrophil infiltration, microglial
      activation, and pro-inflammatory factor release. In addition, DEX alleviated cell
      apoptosis at 24 h after SAH. Notably, DEX could also suppress the activation of
      the TLR4/NF-kappaB pathway and the NLRP3 inflammasome. These findings suggested
      that treatment with DEX after SAH attenuated SAH-induced EBI, partially through
      the suppression of the TLR4/NF-kappaB pathway and the NLRP3 inflammasome.

PMID- 29842861
TI  - Neuroprotective effect of acute prior inflammation with lipopolysaccharide for
      adult male rat facial motoneurones.
AB  - Increases in inflammatory cytokines are reported to have both neuroprotective and
      neurotoxic effects depending on the type and age of neurones studied. This study
      aimed to determine the effect of experimental inflammation induced by
      Lipopolysaccharide (LPS) on the survival of injured male adult rat facial
      motoneurones. Time- and dose-response studies were done to optimise the LPS
      administration time and dose, to best correlate with inflammatory levels
      previously reported for aged rats. 12 cytokines were assayed through multiplex
      analysis. 24 h after intraperitoneal injection of 0.5 mg/kg Lipopolysaccharide in
      rats, IL-1beta, IL-5 and IL-12p70 levels were elevated, with no observed LPS
      associated sickness behaviour. In other groups of 5-6 adult rats, the facial
      nerve was either crushed (as mild injury) or avulsed (as severe injury) after the
      LPS priming injection. Stereology revealed that most motoneurones survived 28
      days after nerve crush only and LPS- or saline-priming preceding nerve crush.
      Most motoneurones died following nerve avulsion only, whereas over half survived
      when LPS-priming preceded nerve avulsion. We suggest that elevated levels of
      experimental inflammation are neuroprotective for severely injured adult male rat
      facial motoneurones.

PMID- 29842862
TI  - Investigation of binding characteristics of immobilized toll-like receptor 3 with
      poly(I:C) for potential biosensor application.
AB  - Toll-like receptor 3 (TLR3), a pathogen recognition receptor of the innate immune
      response, recognizes and is activated by double-stranded RNA (dsRNA), which is
      indicative of viral exposure. A sensor design exercise was conducted, using
      surface plasmon resonance detection, through the examination of several
      immobilization approaches for TLR3 as a biorecognition element (BRE) onto a
      modified gold surface. To examine the TLR3-dsRNA interaction a synthetic analogue
      mimic, poly (I:C), was used. The interaction binding characteristics were
      determined and compared to literature data to establish the optimal
      immobilization method for the TLR3 BRE. A preliminary evaluation of the efficacy
      of the selected TLR3 surface as a broad-spectrum viral biosensor was also
      performed. Amine-coupling was found to be the most reliable method for
      manufacturing repeatable and consistent TLR3 BRE sensor surfaces, although this
      immobilization schema is not tailored to place the receptor in a spatially
      specific orientation. The equilibrium dissociation constant (KD) measured for
      this immobilized TLR3-poly (I:C) interaction was 117 +/- 3.30 pM. This evaluation
      included a cross-reactivity study using a selection of purified E. coli and
      synthetic double- and single-stranded nucleic acids. The results of this design
      exercise and ligand binding study will inform future work towards the development
      of a broad-spectrum viral sensor device.

PMID- 29842863
TI  - Molecular basis of growth hormone daily mRNA and protein synthesis in rats.
AB  - AIMS: Daily and seasonal rhythms coordinate the endocrine and metabolic
      functions. The pituitary gland is the master regulator of several endocrine
      activities, and its function is classically regulated by endocrine signals from
      its target glands as well as from the hypothalamus. The growth hormone (GH)
      produced and secreted by the anterior pituitary presents a pulsatile secretion
      throughout the 24-hour cycle. However, the molecular mechanisms regulating the
      daily pattern of GH secretion are still unclear. Herein we investigated whether
      circadian GH mRNA and protein synthesis is modulated by acute adjustments in the
      stability and expression of GH mRNA. MAIN METHODS: GH mRNA and protein content
      were evaluated by real-time PCR and Western blotting, respectively, in pituitary
      gland of rats euthanized every 3 h during a 24-h period at the Zeitgeber times
      (ZT3 to ZT24). The GH mRNA poly(A) tail length was determined by RACE-PAT assay.
      KEY FINDINGS: We identified two main peaks of GH mRNA level in the pituitary
      gland of rats; one in the middle of the light-cycle and another in the middle of
      the dark-cycle. The latter was associated with an increase in pituitary GH
      protein content. Interestingly, an increment in the poly(A) tail length of the GH
      transcript was observed in association to reduced migration rate of the GH
      transcript and increased mRNA content in the dark-cycle period. SIGNIFICANCE: Our
      findings provide evidence that changes in the GH mRNA poly(A) length may underlie
      the circadian pattern of GH mRNA and protein levels in the pituitary gland of
      rats.

PMID- 29842864
TI  - New thinking about thinking, part two. Theoretical articles for Alzheimer's &
      Dementia.

PMID- 29842865
TI  - Historical record-setting trends in IUD use in the United States.

PMID- 29842866
TI  - With-in host dynamics of L. monocytogenes and thresholds for distinct infection
      scenarios.
AB  - The case fatality and illness rates associated with L. monocytogenes continue to
      pose a serious public health burden despite the significant efforts and control
      protocol administered by private and public sectors. Due to the advance in
      surveillance and improvement in detection methodology, the knowledge of sources,
      transmission routes, growth potential in food process units and storage, effect
      of pH and temperature are well understood. However, the with-in host growth and
      transmission mechanisms of L. monocytogenes, particularly within the human host,
      remain unclear, largely due to the limited access to scientific experimentation
      on the human population. In order to provide insight towards the human immune
      response to the infection caused by L. monocytogenes, we develop a with-in host
      mathematical model. The model explains, in terms of biological parameters, the
      states of asymptomatic infection, mild infection and systemic infection leading
      to listeriosis. The activation and proliferation of T-cells are found to be
      critical for the susceptibility of the infection. Utilizing stability analysis
      and numerical simulation, the ranges of the critical parameters relative to
      infection states are established. Bifurcation analysis shows the impact of the
      differences of these parameters on the dynamics of the model. Finally, we present
      model applications in regards to predicting the risk potential of listeriosis
      relative to the susceptible human population.

PMID- 29842867
TI  - Characterization of the honeybee venom proteins C1q-like protein and PVF1 and
      their allergenic potential.
AB  - Honeybee (Apis mellifera) venom (HBV) represents an ideal model to study the role
      of particular venom components in allergic reactions in sensitized individuals as
      well as in the eusociality of Hymenoptera species. The aim of this study was to
      further characterize the HBV components C1q-like protein (C1q) and PDGF/VEGF-like
      factor 1 (PVF1). C1q and PVF1 were produced as recombinant proteins in insect
      cells. Their allergenic properties were examined by determining the level of
      specific IgE antibodies in the sera of HBV-allergic patients (n = 26) as well as
      by their capacity to activate patients' basophils (n = 11). Moreover, the
      transcript heterogeneity of PVF1 was analyzed. It could be demonstrated that at
      least three PVF1 variants are present in the venom gland, which all result from
      alternative splicing of one transcript. Additionally, recombinant C1q and PVF1
      from Spodoptera frugiperda insect cells exhibited specific IgE reactivity with
      approximately 38.5% of sera of HBV-allergic patients. Interestingly, both
      proteins were unable to activate basophils of the patients, questioning their
      role in the context of clinically relevant sensitization. Recombinant C1q and
      PVF1 can build the basis for a deeper understanding of the molecular mechanisms
      of Hymenoptera venoms. Moreover, the conflicting results between IgE
      sensitization and lack of basophil activation, might in the future contribute to
      the identification of factors that determine the allergenic potential of
      proteins.

PMID- 29842868
TI  - Effect of beef ingestion by humans on plasma concentrations of creatinine, urea,
      and cystatin C.
AB  - PURPOSE: The effect of eating meat on serum concentrations of creatinine has
      varied among previous reports, with some finding no effect and others finding 50
      100% increases, which appears related to how the beef is cooked. For other
      analytes related to kidney function, urea is well known to increase following a
      protein meal, and the effect of eating meat on cystatin C concentrations has been
      studied once. METHODS: We had 32 participants eat a measured amount of cooked
      beef (5-6 or 10-12 oz; 142-170 or 284-340 g) and collected blood for measurements
      at 1 h before and immediately before eating beef, then at 1, 2, and 4 h after
      eating the beef. We measured creatinine using both alkaline picrate and enzymatic
      methods, cystatin C using a nephelometric immunoassay, and urea using an
      enzymatic method. RESULTS: For creatinine, both the picrate and enzymatic methods
      showed similar responses, with a peak average increases of 5.9 MUmol/L (0.07
      mg/dL) and 4.6 MUmol/L (0.05 mg/dL), respectively, at 2 h. Cystatin C had a very
      slightly maximal decrease of -0.037 mg/L at 2 h. Urea had the largest change,
      increasing by 0.30 and 0.77 mmol/L at 2 and 4 h respectively. CONCLUSIONS:
      Healthy individuals were found to have minor increases in serum creatinine (~5
      MUmol/L) following the ingestion of 5/6 or 10/12 oz of fried beef. Cystatin C
      appears to decrease very slightly in some people after beef ingestion, possibly
      due either to circadian variation or to a hormonal effect of eating. We conclude
      that ingesting these amounts of fried beef has a small effect on plasma
      creatinine concentrations. Although these increases would likely not affect the
      diagnosis of a kidney impairment in this population or in those with kidney
      disease, eating meat before collecting blood for creatinine measurement should be
      avoided.

PMID- 29842869
TI  - Effect of vitrification on human oocyte maturation rate during in vitro
      maturation procedure: A systematic review and meta-analysis.
AB  - Combination of in vitro maturation (IVM) and cryopreservation offers new
      opportunities for women with contraindication in ovarian stimulation, and females
      who desire to postpone the childbearing due to different problems. There are
      still controversies regarding IVM procedure and its impact on oocytes
      fertilization capability. This systematic review and meta-analysis were conducted
      to evaluate the impact of vitrification on human oocyte maturation rate during
      IVM procedure. In this review, we searched Medline, Embase, Scopus and ISI web of
      science to identify English-language studies. The last search was implemented on
      3 February 2018. The original articles which assessed maturation rate after
      vitrification of MI or GV oocytes were included. Animal trials and the studies
      that performed cryopreservation using slow-freeze method were excluded. Bias and
      quality assessments were performed. 2476 articles were screened primarily. After
      duplication removing and the application of inclusion and exclusion criteria, 14
      studies included for the analysis. All studies compared maturation rate between
      the oocytes that were vitrified at the GV or MI stage before maturation and
      oocytes which were matured in vitro without vitrification. Meta-analysis showed
      that oocyte vitrification at GV stage had a significant negative impact on
      maturation rate (RR = 0.76, 95% CI: 0.66-0.88); I2 = 85.2%; P = 0.000). Finally,
      based on our results, oocyte vitrification decreases the maturation rate by 24%.

PMID- 29842871
TI  - Serum derived from ulcerative colitis mouse changes the metabolism of the
      fluorescent substrate by P450 depending on the degree of disease progression.
AB  - Ulcerative colitis (UC) is characterized by erosions of the intestinal mucosa.
      The number of patients with UC has recently been increasing rapidly. Since the
      diagnosis of UC is complex and difficult, a simple, rapid, noninvasive technique
      for diagnosing UC is needed urgently. The expression of cytochrome P450 (P450 or
      CYP) species in mouse liver is known to be changed dependent on the disease.
      Various components such as P450 substrates and P450 metabolites in the blood may
      possibly change with the UC-specific way in mouse. In this study, in order to
      evaluate UC-specific components in UC mouse serum, we analyzed the influence of
      serum derived from UC mice on the results of fluorescent P450 inhibition assays
      based on 12 human P450 enzymes, such as CYP1A1, CYP2C8, CYP2E1,CYP3A4, CYP1A2,
      CYP2D6, CYP2A13, CYP2B6, CYP2C9, CYP2C18, CYP2C19, and CYP3A5. At first, in order
      to induce UC, mice received 4,4-dimethyl-4-silapentane-1-sulfonic acid (DSS)
      dissolved in their drinking water for 7 days. Next, these 12 human P450 enzymes
      were expressed in E. coli cells. Then, P450 fluorescent competition reaction was
      performed using these P450 enzymes and serum of UC mice. We found that the
      metabolism of fluorescent substrates by CYP2B6, CYP2C19, CYP2E1, and CYP1A1 in
      the presence of serum obtained from DSS-treated mice was activated by 42%, 37%,
      37%, and 23%, respectively, relative to that associated with sera from control
      mice. A receiver operating characteristic (ROC) curve analysis was carried out
      with the 31 samples of UC mice and healthy mice. Area under the ROC curve (AUC)
      value was calculated from ROC curve. AUC value of CYP2E1 and CYP2C19 showed 0.921
      and 0.892, respectively. Therefore, it was shown that CYP2C19 and CYP2E1 could be
      used as biomarkers for evaluating ulcerative colitis. From these results, it is
      suggested that these simple fluorescent P450 inhibition assays have potential as
      a new diagnostic procedure for UC in mouse. This study is the first report on a
      simple non-invasive method for evaluating UC using P450 enzyme and serum
      interaction.

PMID- 29842870
TI  - Impact of prepubertal exposure to dietary protocatechuic acid on the hypothalamic
      pituitary-testicular axis in rats.
AB  - Protocatechuic acid (PCA; 3, 4-dihydroxybenzoic acid) is a phenolic compound
      widely found in many edible fruits, vegetables, grape wine and plant-derived
      beverages. The present study investigated the impact of PCA on the hypothalamic
      pituitary-testicular axis of rats orally treated with PCA during the period of
      prepubertal development to adulthood. Protocatechuic acid was administered to
      prepubertal male rats at doses of 0, 5, 10, 50 and 100 mg/kg body for 45
      consecutive days. The results revealed no treatment-related changes in the body
      weight gain and organo-somatic indices of the hypothalamus, testes, epididymis,
      prostate gland and seminal vesicle in rats administered with PCA when compared
      with control. However, prepubertal exposure to PCA significantly enhanced
      antioxidant enzyme activities and glutathione level whereas it markedly decreased
      biomarkers of inflammation and oxidative stress in the hypothalamus, testes and
      epididymis of the treated rats. Protocatechuic acid significantly increased
      circulatory concentrations of luteinizing hormone and follicle-stimulating
      hormone with concomitant increase in serum and intra-testicular testosterone
      levels. Moreover, PCA-treated rats exhibited significant increase in marker
      enzymes of testicular function namely acid phosphatase, alkaline phosphatase,
      lactate dehydrogenase and glucose-6-phosphate dehydrogenase without statistically
      significant increase in spermatogenesis and sperm functional characteristics
      including sperm count, motility and viability. Light microscopic examination of
      the hypothalamus, testes and epididymis of rats treated with PCA showed histo
      architectures similar to control. In conclusion, prepubertal exposure to PCA is
      safe and positively impacted reproductive function at sexual maturity in male
      rats. The observed beneficial effects of PCA is related to its anti-inflammatory
      and redox regulatory mechanisms.

PMID- 29842872
TI  - Inability to work due to Chikungunya virus infection: impact on public service
      during the first epidemic in the State of Ceara, northeastern Brazil.

PMID- 29842873
TI  - Hypokalemia in an End-Stage Renal Disease Patient.

PMID- 29842874
TI  - Influence of resveratrol on interactions between negatively charged DPPC/DPPG
      membranes and positively charged poly-l-lysine.
AB  - Resveratrol (Res), a natural polyphenol present in different plants and
      vegetables, exhibits potential therapeutic activity with cardioprotective,
      antineurodegenerative, antioxidant, and antitumor action. In this study, the
      effect of Res on the mutual interactions between positively charged poly-l-lysine
      (PLL) and negatively charged
      dipalmitoylphosphatidylcholine/dipalmitoylphosphatidylglycerol (DPPC/DPPG)
      membranes was studied using Fourier-transform infrared (FTIR) spectroscopy
      supported by principal component analysis (PCA). The interactions between PLL and
      DPPC/DPPG membranes were strongly affected by the presence of Res molecules.
      Depending on the Res concentration and method of its supply (through the water or
      lipid phase) to the studied peptide-membrane systems, the membrane-induced
      transition of PLL from an alpha-helix to an extended left-handed polyproline II
      helix (PPII) occurred at different temperatures, with different cooperativity, or
      was even completely suppressed. The influence of PLL on the conformational
      (trans/gauche) state of the hydrocarbon chain region of the lipid membranes and
      the hydration state of the polar/apolar membrane interface was also modulated by
      Res, depending on the membrane phase state.

PMID- 29842875
TI  - Peripheral gabapentin regulates mosquito allergy-induced itch in mice.
AB  - The antipruritic activity of gabapentin, an anticonvulsant, was studied in a
      mouse model of allergic itch. In mice sensitized by an extract of the salivary
      glands of the mosquito (ESGM), an intradermal injection of ESGM elicited
      scratching and increased peripheral nerve firing. Oral or intradermal
      administration of gabapentin at the ESGM injection site inhibited ESGM-induced
      scratching and peripheral nerve firing. However, gabapentin did not affect
      histamine-induced scratching. The distributions of immunoreactivity to the
      voltage-dependent calcium channel alpha2delta-1 subunit, a site of gabapentin
      action, and the histamine H1 receptor differed in the mouse dorsal root ganglia.
      The alpha2delta-1 subunit was mainly found in neurons that were 15-20 um in
      diameter, whereas the H1 receptor was mainly in 20-30 um neurons. In addition,
      alpha2delta-1 subunit immunoreactivity co-localized with that of transient
      receptor potential vanilloid 1 (TRPV1). These results suggest that gabapentin
      regulates allergic itch by acting on the calcium channel alpha2delta-1 subunit in
      peripheral TRPV1-positive neurons.

PMID- 29842876
TI  - Vascular endothelial growth factor aggravates cerebral ischemia and reperfusion
      induced blood-brain-barrier disruption through regulating LOC102640519/HOXC13/ZO
      1 signaling.
AB  - BACKGROUND/OBJECTIVE: Vascular endothelial growth factor (VEGF) has been
      recognized to be a potential pharmaceutical target for treating ischemic stroke,
      but its severe side effects hinder its widely application. Here, the present
      study was designed to investigate the effects of VEGF on blood-brain-barrier
      (BBB) disruption and the underlying mechanisms. METHODS: A mouse model of middle
      cerebral artery occlusion (MCAO) was constructed and treated with or without
      VEGF. Meanwhile, mice brain microvascular endothelial cells in co-culture with
      astrocytes were subjected to 1, 2 and 4 h oxygen-glucose deprivation followed by
      24 h of reperfusion (OGD/R) in the absence or presence of VEGF. The mRNA and
      protein expression were assessed by real-time PCR and Western blotting.
      Fluorescence in situ hybridization (FISH) was utilized to validate LOC102640519
      expression in OGD/R cell models. Chromatin Immunoprecipitation (ChIP) assay was
      used to confirm the regulatory mechanism of LOC102640519 to HOXC13. Interactions
      between HOXC13 and ZO-1 were measured by a luciferase reporter assay and RNA pull
      down assay. RESULTS: Our results showed that administration of VEGF significantly
      aggravated BBB by upregulating LOC102640519 and HOXC13 expression in vitro and
      vitro model of cerebral ischemia. Furthermore, LOC102640519 positively regulated
      the expression of HOXC13, thus negatively regulated the expression of ZO-1,
      Occludin and Claudin-5 in OGD/R model in the absence or presence of VEGF.
      CONCLUSIONS: VEGF aggravated BBB disruption after cerebral I/R-induced injury
      probably by increasing LOC102640519 and HOXC13 through inhibition of ZO-1,
      Occludin and Claudin-5.

PMID- 29842877
TI  - Heterogeneity of adult masseter muscle satellite cells with cardiomyocyte
      differentiation potential.
AB  - Although resident cardiac stem cells have been reported, regeneration of
      functional cardiomyocytes (CMs) remains a challenge. The present study identifies
      an alternative progenitor source for CM regeneration without the need for genetic
      manipulation or invasive heart biopsy procedures. Unlike limb skeletal muscles,
      masseter muscles (MM) in the mouse head are developed from Nkx2-5 mesodermal
      progenitors. Adult masseter muscle satellite cells (MMSCs) display heterogeneity
      in developmental origin and cell phenotypes. The heterogeneous MMSCs that can be
      characterized by cell sorting based on stem cell antigen-1 (Sca1) show different
      lineage potential. While cardiogenic potential is preserved in Sca1+ MMSCs as
      shown by expression of cardiac progenitor genes (including Nkx2-5), skeletal
      myogenic capacity is maintained in Sca1- MMSCs with Pax7 expression. Sca1+ MMSC
      derived beating cells express cardiac genes and exhibit CM-like morphology.
      Electrophysiological properties of MMSC-derived CMs are demonstrated by calcium
      transients and action potentials. These findings show that MMSCs could serve as a
      novel cell source for cardiomyocyte replacement.

PMID- 29842878
TI  - The development of methods for primary mast cells in vitro and ex vivo: An
      historical review.
AB  - Mast cells (MCs) are tissue-based stationary effector cells that form the immune
      system's first-line defense against various challenges. They are developed from
      the bone marrow-derived progenitors to complete their differentiation and
      maturation in the tissues where they eventually establish residence. MCs have
      been implicated in many diseases, such as allergy, parasitic infection, and
      neoplastic disorders. Immortalized MC lines, such as RBL-2H3, HMC-1, and LAD-2,
      are useful for investigating the biological functions of MC only to some extents
      due to the restriction of degranulation evaluation, in vivo injection and other
      factors. Over the past few decades, technologies for acquiring primarily MCs have
      been continually optimized, and novel protocols have been proposed. However, no
      relevant publications have analyzed and summarized these techniques. In this
      review, the classical approaches for extracting MCs are generalized, and new
      methods with potential values are introduced. We also evaluate the advantages and
      applicability of diverse MC models. Since MCs exhibit substantial plasticity and
      functional diversity due to different origins, it is both necessary and urgent to
      select a reliable and suitable source of MCs for a particular study.

PMID- 29842879
TI  - Oxaliplatin and irinotecan induce heterogenous changes in the EMT markers of
      metastasizing colorectal carcinoma cells.
AB  - In patients with advanced colorectal cancer (CRC), surgery is complemented with
      systemic therapy - chemotherapy and radiochemotherapy. Although the patients'
      overall survival has been significantly improved, tumor resistance is still a
      frequent cause of chemotherapy failure. Several factors contribute to
      chemoresistance of tumor cells including changes related with epithelial
      mesenchymal transition (EMT). The present study was designed to verify the
      presence of EMT markers in paired CRC primary cell lines obtained from primary
      tumor sites and lymph node metastases of three patients and to investigate the
      effect of irinotecan and oxaliplatin treatment on these markers as well. The
      samples of the higher stage of CRC and positive for angioinvasion were selected
      and qPCR, western blot analysis, migration assay, cytotoxicity testing was
      performed. Results confirmed the increased expression of several markers
      characteristic of EMT and invasiveness in lymph node metastatic cells, with a
      significant variability between individual samples. Irinotecan and oxaliplatin
      decreased migration activity of the cells and to the varying degree affected the
      expression of EMT and invasiveness markers. In conclusion, in CRC EMT is present
      in metastatic cells over a phenotypic continuum whose expression is altered
      heterogeneously upon irinotecan and oxaliplatin treatment.

PMID- 29842880
TI  - Differential transcription factor expression by human epithelial cells of buccal
      and urothelial derivation.
AB  - Identification of transcription factors expressed by differentiated cells is
      informative not only of tissue-specific pathways, but to help identify master
      regulators for cellular reprogramming. If applied, such an approach could
      generate healthy autologous tissue-specific cells for clinical use where cells
      from the homologous tissue are unavailable due to disease. Normal human
      epithelial cells of buccal and urothelial derivation maintained in identical
      culture conditions that lacked significant instructive or permissive signaling
      cues were found to display inherent similarities and differences of phenotype.
      Investigation of transcription factors implicated in driving urothelial-type
      differentiation revealed buccal epithelial cells to have minimal or absent
      expression of PPARG, GATA3 and FOXA1 genes. Retroviral overexpression of protein
      coding sequences for GATA3 or PPARy1 in buccal epithelial cells resulted in
      nuclear immunolocalisation of the respective proteins, with both transductions
      also inducing expression of the urothelial differentiation-associated claudin 3
      tight junction protein. PPARG1 overexpression alone entrained expression of
      nuclear FOXA1 and GATA3 proteins, providing objective evidence of its upstream
      positioning in a transcription factor network and identifying it as a candidate
      factor for urothelial-type transdifferentiation or reprogramming.

PMID- 29842881
TI  - Sodium benzoate induced developmental defects, oxidative stress and anxiety-like
      behaviour in zebrafish larva.
AB  - Sodium benzoate (SB) is a common food preservative. Its FDA described safety
      limit is 1000 ppm. Lately, increased use of SB has prompted investigations
      regarding its effects on biological systems. Data regarding toxicity of SB is
      divergent and controversial with studies reporting both harmful and beneficial
      effects. Therefore, we did a systematic dose dependent toxicity study of SB using
      zebrafish vertebrate animal model. We also investigated oxidative stress and
      anxiety-like behaviour in zebrafish larva treated with SB. Our results indicate
      that SB induced developmental (delayed hatching), morphological (pericardial
      edema, yolk sac edema and tail bending), biochemical (oxidative stress) and
      behavioural (anxiety-like behaviour) abnormalities in developing zebrafish larva.
      LC50 of SB induced toxicity was approximately 400 ppm after 48 h of SB exposure.
      Our study strongly supports its harmful effects on vertebrates at increasing
      doses. Thus, we suggest caution in the excessive use of this preservative in
      processed and convenience foods.

PMID- 29842882
TI  - Histone methyltransferase SETD2 regulates osteosarcoma cell growth and
      chemosensitivity by suppressing Wnt/beta-catenin signaling.
AB  - SETD2 is a histone methyltransferase that catalyzes the trimethylation of lysine
      36 on histone 3. SETD2 is frequently found to be mutated or deleted in a variety
      of human tumors, whereas the role of SETD2 in oncogenesis of osteosarcoma has
      never been defined. Here in our study, we uncovered that SETD2 regulates tumor
      growth and chemosensitivity of osteosarcoma. Overexpression of SETD2
      significantly inhibited osteosarcoma cell growth in vitro and in vivo. Moreover,
      SETD2 significantly enhanced cisplatin-induced apoptosis in osteosarcoma cells
      and inhibited cancer stem cell properties in OS cells. SETD2 regulates Wnt/beta
      catenin signaling and its downstream gene c-myc, CD133 and cyclin D1. We further
      revealed that SETD2 upregulates H3K36me3 modification in GSK3B loci and promotes
      its transcription, which lead to beta-catenin degradation. Together, our study
      delineates SETD2 function in osteosarcoma as an important regulator of Wnt/beta
      catenin signaling, and suggests SETD2 as a novel target in diagnosis and combined
      chemotherapy of osteosarcoma.

PMID- 29842883
TI  - Expression and effects of TSP50 in mouse embryo and cardiac myocyte development.
AB  - TSP50, a testis-specific gene encoding a serine protease-like protein, was
      specifically expressed in the spermatocytes of testes but abnormally activated
      and expressed in many different kinds of cancers. Here, we aimed to analyze the
      expression of TSP50 in mouse embryo and its function in early embryonic
      development. Firstly, the distribution of TSP50 in oocytes and embryonic
      development was characterized by immunofluorescence, RT-PCR and western blotting,
      and the results showed that TSP50 was detected at all studied stages with a
      dynamic expression pattern. When overexpressed TSP50 in zygotes by
      microinjection, the zygotes development was highly accelerated. On the contrary,
      knocking down TSP50 expression by RNA interference greatly retarded the zygote
      development. Furthermore, TSP50 expression at embryonic day 6.5 (E6.5), day 8.5
      (E8.5) and day 10.5 (E10.5) were increasingly enhanced, However, the expression
      of TSP50 decreased gradually in the development and differentiation of cardiac
      myocyte from E12.5 to postnatal (P0). Additionally, we found that TSP50
      expression was decreased during cardiac myocyte differentiation of P19 cells.
      Overexpression of TSP50 could decrease the expression of GATA-4, and knockdown of
      TSP50 markedly increase the expression of GATA-4. Taken together, our data
      indicate that TSP50 may play an important role during the process of mouse
      embryonic development as well as myocardial cell differentiation.

PMID- 29842884
TI  - Novel localization of Aurora A kinase in mouse testis suggests multiple roles in
      spermatogenesis.
AB  - Male germ cells are transformed from undifferentiated stem cells into spermatozoa
      through a series of highly regulated steps together termed spermatogenesis.
      Spermatogonial stem cells undergo mitosis and differentiation followed by two
      rounds of meiotic division and then proceed through a series of dramatic cell
      shape changes to form highly differentiated spermatozoa. Using indirect
      immunofluorescence, we investigated a role for the mitotic kinase, Aurora A
      (AURKA), in these events through localization of this protein in mouse testis and
      spermatozoa. AURKA is expressed in several cell types in the testis.
      Spermatogonia and spermatocytes express AURKA as expected based on the known role
      of this kinase in cell division. Surprisingly, we also found AURKA localized to
      spermatids and the flagellum of spermatozoa. Total AURKA and activated AURKA are
      expressed in different compartments of the sperm flagellum with total AURKA found
      in the principal piece and its phosphorylated and activated form found in the
      sperm midpiece. In addition, active AURKA is enriched in the flagellum of motile
      sperm isolated from cauda epididymis. These results provide evidence for a unique
      role for AURKA in spermatogenesis and sperm motility. Defining the signaling
      mechanisms that govern spermatogenesis and sperm cell function is crucial to
      understanding and treating male infertility as well as for development of new
      contraceptive strategies.

PMID- 29842885
TI  - m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma
      by regulating MZF1 expression.
AB  - N6-Methyladenosine (m6A) represents the most prevalent internal modification in
      mammalian mRNAs. Emerging evidences suggest that m6A modification is profoundly
      implicated in many biological processes, including cancer development. However,
      limited knowledge is available about the functional importance of m6A in lung
      cancer. In this study, by data mining The Cancer Genome Atlas (TCGA) database, we
      first identified fat mass- and obesity-associated protein (FTO) as a prognostic
      factor for lung squamous cell carcinoma (LUSC). Then we showed that FTO, but not
      other m6A modification genes including METTL3, METTL14 and ALKBH5, was the major
      dysregulated factor responsible for aberrant m6A modification in LUSC. Loss-of
      function studies suggested that FTO knockdown effectively inhibited cell
      proliferation and invasion, while promoted cell apoptosis of L78 and NCI-H520
      cells. Furthermore, overexpression of FTO, but not its mutant form, facilitated
      the malignant phenotypes of CHLH-1 cells. Mechanistically, FTO enhanced MZF1
      expression by reducing m6A levels and mRNA stability in MZF1 mRNA transcript,
      leading to oncogenic functions. Taken together, our study demonstrates the
      functional importance of FTO in the tumor progression of LUSC and provides a
      potential therapeutic target for LUSC treatment.

PMID- 29842886
TI  - Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation
      and invasion by sponging miR-1261 and facilitating C8orf4 expression.
AB  - In recent years, more and more circular RNAs (circRNAs) have been identified in
      multiple tissues and cells. Increasing evidences show circRNAs play important
      roles in human cancers. However, the role of circRNAs in papillary thyroid
      carcinoma (PTC) remains largely unknown. In this study, we identified a new
      circRNA circZFR that was significantly upregulated in PTC tissues compared to
      adjacent normal tissues. Furthermore, circZFR expression level was negatively
      correlated with clinical severity. We found that circZFR knockdown dramatically
      inhibited the proliferation, migration and invasion of PTC cells in vitro.
      Mechanistically, we found circZFR could promote C8orf4 expression via serving as
      a competing endogenous RNA (ceRNA) of miR-1261 in PTC cells. Rescue assays
      indicated that restoration of C8orf4 significantly attenuated the inhibitory
      effects of circZFR knockdown on PTC cell proliferation, migration and invasion.
      In summary, our findings demonstrated that circRNA circZFR exerted oncogenic
      roles via regulating miR-1261/C8orf4 axis in PTC, which suggested circZFR might
      be a potential therapeutic target.

PMID- 29842888
TI  - Cyclodextrin-grafted poly(anhydride) nanoparticles for oral glibenclamide
      administration. In vivo evaluation using C. elegans.
AB  - The aim of this work was to prepare and evaluate cyclodextrins-modified
      poly(anhydride) nanoparticles to enhance the oral administration of
      glibenclamide. A conjugate polymer was synthesized by incorporating hydroxypropyl
      beta-cyclodextrin to the backbone of poly(methylvinyl ether-co-maleic anhydride)
      via Steglich reaction. The degree of substitution of anhydride rings by
      cyclodextrins molecules was calculated to be 4.9% using H-NMR spectroscopy. A
      central composite design of experiments was used to optimize the preparative
      process. Under the optimal conditions, nanoparticles displayed a size of about
      170 nm, a surface charge of -47 mV and a drug loading of 69 ug GB/mg. X-ray
      diffraction studies confirmed the loss of the crystalline structure of GB due to
      its dispersion into the nanoparticles, either included into cyclodextrin cavities
      or entrapped in the polymer chains. Glibenclamide was mainly release by Fickian
      diffusion in simulated intestinal fluid. GB-loaded nanoparticles produced a
      hypolipidemic effect over C. elegans N2 wild-type and daf-2 mutant. The action
      mechanism included daf-2 and daf-28 genes, both implicated in the insulin
      signaling pathway of C. elegans. In summary, the covalent linkage of cyclodextrin
      to the poly(anhydride) backbone could be an interesting strategy to prepare
      nanoparticles for the oral administration of glibenclamide.

PMID- 29842889
TI  - Toxicity of imidazoles ionic liquid [C16mim]Cl to HepG2 cells.
AB  - Ionic liquids have garnered increasing attention due to their capacity for low
      vapor pressure, lack of flammability, designability, good stability, and as a
      asubstitute for conventional organic solvents. However, their toxicity to various
      organisms has caused growing concern in recent years. Our study aims to evaluate
      the toxicity of 1-hexadecyl-3-methylimidazolium chloride ([C16min]Cl) to human
      hepatocellular carcinoma (HepG2) cells, including cell viability, genotoxicity,
      oxidative stress, apoptosis, cell cycle, and apoptosis-related gene expression.
      Our results with HepG2 cells suggested that [C16min]Cl inhibited cellular growth,
      decreased cell viability, induced DNA damage and apoptosis, inhibited superoxide
      dismutase, decreased glutathione content, increased cellular malondialdehyde
      levels as well as altering the cell cycle. Moreover, the induction of [C16min]Cl
      altered the transcription of p53, Bax and Bcl-2, which are critical for
      controlling cell cycles progression and death, which suggests its involvement
      with cytotoxicity and apoptosis induced by [C16min]Cl in HepG2 cells. Taken
      together, these results revealed that [C16min]Cl exerted genotoxicity, oxidative
      stress and induced apoptosis in HepG2 cells; hence, it is not a healthy solvent.

PMID- 29842887
TI  - Thalamic integration of social stimuli regulating parental behavior and the
      oxytocin system.
AB  - Critically important components of the maternal neural circuit in the preoptic
      area robustly activated by suckling were recently identified. In turn, suckling
      also contributes to hormonal adaptations to motherhood, which includes oxytocin
      release and consequent milk ejection. Other reproductive or social stimuli can
      also trigger the release of oxytocin centrally, influencing parental or social
      behaviors. However, the neuronal pathways that transfer suckling and other
      somatosensory stimuli to the preoptic area and oxytocin neurons have been poorly
      characterized. Recently, a relay center of suckling was determined and
      characterized in the posterior intralaminar complex of the thalamus (PIL). Its
      neurons containing tuberoinfundibular peptide 39 project to both the preoptic
      area and oxytocin neurons in the hypothalamus. The present review argues that the
      PIL is a major relay nucleus conveying somatosensory information supporting
      maternal behavior and oxytocin release in mothers, and may be involved more
      generally in social cue evoked oxytocin release, too.

PMID- 29842890
TI  - mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and
      7 in perinatal brain development.
AB  - TRPM7 and TRPM2 are non-specific cation channels of the Transient Receptor
      Potential channel superfamily. Each channel has gained attention for their
      potential to mediate oxidative and anoxic cell death (Rama and Garcia, 2016;
      Naziroglu, 2011a; Abiria et al., 2017; Sun, 2017), however their physiological
      expression and roles in the developing brain remain poorly defined. We employed
      real-time reverse transcription PCR to examine mRNA expression of TRPM7 and TRPM2
      in the developing rat brain and brain-specific cell types. We determined the
      temporal and spatial expression patterns at four developmental time points
      (postnatal day 7, 14, 21, and 90) in four critical regions of the brain (cortex,
      hippocampus, striatum, and cerebellum) and examined gene expression in neuronal,
      astrocytic, and microglial primary cell cultures. Our results revealed that TRPM7
      mRNA expression peaks in the cortex at 2-weeks after birth, and thus correlates
      most closely with a period of rat brain development associated with neurite
      outgrowth, which is heightened at 2-weeks after birth. Our cell-specific gene
      expression assays revealed that TRPM7 was expressed at equivalent levels in
      neurons, astrocytes, and microglia. Conversely, TRPM2 was most highly expressed
      in microglia with little expression in neurons and astrocytes. In the hippocampus
      and striatum, the expression profile of TRPM2 parallels the perinatal expression
      timeline for microglial infiltration and maturation in the rat brain. Microglial
      maturation is highest from the time of birth, up to 7-days, but subsequently
      declines. The latter developmental expression profiles indicate a role for TRPM2
      in microglial activation.

PMID- 29842891
TI  - Pattern of tyrosine hydroxylase expression during aging of mesolimbic pathway of
      the rat.
AB  - Senescence is a physiological and progressive event that leads to the impairment
      of normal functions of the organism. The nervous system is one of the most
      affected systems during aging, presenting both structural and functional
      alterations associated with a decline in normal brain functions. In the present
      study we aimed to evaluate the impact of senescence on the mesolimbic pathway
      (nucleus accumbens - NAc and ventral tegmental area - VTA) of the rat, through
      immunohistochemistry for tyrosine hydroxylase (TH) enzyme, in young (3 months
      old), middle-aged (10 months old) and aged animals (18 months old). There was a
      significant decrease in the TH-immunoreactivity across NAc in aged animals as
      compared to the young and middle-aged ones, as revealed by optical densitometry.
      Medium and caudal regions of the VTA in the young animals possessed a higher
      number of TH-immunoreactive neurons as compared to the more aged groups.
      Comparisons among VTA regions in young animals revealed a difference in the
      number of cell bodies when the medium region was compared to the rostral and
      caudal regions whilst in both the middle-aged and aged groups comparisons between
      rostral vs caudal and medium vs caudal regions were significant. Our results show
      that aging impacts the mesolimbic pathway across its rostrocaudal axis, with a
      decrease of TH-reactivity in NAc and loss of neurons in VTA. These events may be
      involved with behavioral alterations observed throughout aging.

PMID- 29842892
TI  - Calcium signaling and the therapeutic targeting of cancer cells.
AB  - The calcium signal is implicated in a variety of processes important in tumor
      progression (e.g. proliferation and invasiveness). The calcium signal has also
      been shown to be important in other processes important in cancer progression
      including the development of resistance to current cancer therapies. In this
      review, we discuss how Ca2+ channels, pumps and exchangers may be drug targets in
      some cancer types. We consider what factors should be taken into account when
      considering an optimal Ca2+ channel, pump or exchanger as a candidate for further
      assessment as a novel drug target in cancer. We also present and summarize how
      some therapies for the treatment of cancer intersect with Ca2+ signaling and how
      pharmacological manipulation of the machinery of Ca2+ signaling could promote the
      effectiveness of some therapies. We also review new therapeutic opportunities for
      Ca2+ signal modulators in the context of the tumor microenvironment.

PMID- 29842893
TI  - Lethal (2) giant larvae regulates pleural mesothelial cell polarity in pleural
      fibrosis.
AB  - Pleural fibrosis is barely reversible and the underlying mechanisms are poorly
      understood. Pleural mesothelial cells (PMCs) which have apical-basal polarity
      play a key role in pleural fibrosis. Loss of cell polarity is involved in the
      development of fibrotic diseases. Partition defective protein (PAR) complex is a
      key regulator of cell polarity. However, changes of PMC polarity and PAR complex
      in pleural fibrosis are still unknown. In this study, we observed that PMC
      polarity was lost in fibrotic pleura. Next we found increased Lethal (2) giant
      larvae (Lgl) bound with aPKC and PAR-6B competing against PAR-3A in PAR complex,
      which led to cell polarity loss. Then we demonstrated that Lgl1 siRNA prevented
      cell polarity loss in PMCs, and Lgl1 conditional knockout (ER-Cre+/
      Lgl1flox/flox) attenuated pleural fibrosis in a mouse model. Our data indicated
      that Lgl1 regulates cell polarity of PMCs, inhibition of Lgl1 and maintenance of
      cell polarity in PMCs could be a potential therapeutic treatment approach for
      pleural fibrosis.

PMID- 29842894
TI  - Non-structured spike sequences of hippocampal neuronal ensembles in awake
      animals.
AB  - The hippocampal network generates synchronized spikes of a large population of
      pyramidal neurons associated with sharp-wave ripples in local field potential
      signals. Ample evidence demonstrates that the synchronized spikes are created by
      sequential activation of hippocampal place cells that correspond to the animal's
      past or future trajectories and are hypothesized to play instrumental roles in
      mnemonic functions. However, not all place-cell spike sequences are precisely
      organized, and some sequences are composed of spikes from non-spatial cells,
      implying that not all hippocampal synchronized events directly replicate learned
      behavioral episodes. While less attention has been given to such non-ordered
      spike sequences, variable and dynamic selection of active neuronal assemblies may
      be optimal mechanisms for rapidly reorganizing functional circuits and self
      developing novel representations to enable flexible decision-making processes. We
      recently showed that specific neurons, including both spatial and non-spatial
      cells, are preferentially recruited in synchronous events for particular time
      periods, suggesting that there are temporally fluctuating background states of
      the hippocampal network that determine active neuronal ensembles. Based on recent
      reports, this review discusses potential roles of the low-fidelity, heterogeneous
      repertoire of synchronized spike sequences of hippocampal neurons.

PMID- 29842895
TI  - CD8dim but not CD8bright cells positive to CD56 dominantly express KIR and are
      cytotoxic during visceral leishmaniasis.
AB  - This study reports a structural and functional heterogeneity of CD8+CD56+NKT
      cells, which usually decrease quantitatively during visceral leishmaniasis. Based
      on fluorescence intensity of CD8 receptors on CD56+NKT cells, two populations of
      CD8+CD56+NKT cells have been identified. These cells were recognized as
      CD8dimCD56+NKT and CD8brightCD56+NKT cells. We further analyzed the functional
      nature of CD8dim and CD8bright positive CD56+NKT cells. In comparison to
      CD8brightCD56+NKT cells, a significantly higher percentage of CD8dimCD56+NKT
      cells expressed KIR during VL. The percentage of CD8dimCD56+NKT cells expressing
      KIR was found 4 fold higher in VL as compared to healthy subjects. But, the
      difference was insignificant in case of CD8brightCD56+NKT cells. CD8+CD56+NKT
      cells release granzyme B to kill the infected cells. A categorical difference was
      also observed in the function of CD8dimCD56+NKT and CD8brightCD56+NKT cells
      during visceral leishmaniasis. The percentage of granzyme B expressing
      CD8dimCD56+NKT cells was 2.83 fold higher in VL compared to healthy subjects.
      But, there was no significant difference in granzyme B expressing
      CD8brightCD56+NKT cells in samples from healthy and VL subjects. However, within
      VL subject, the percentage of granzyme B expressing CD8dimCD56+NKT cells was 5.7
      fold higher in comparison to CD8brightCD56+NKT cells. This study concludes that
      CD8dimCD56+NKT cells are more cytotoxic than CD8brightCD56+NKT cells during VL.

PMID- 29842896
TI  - Oxygen: NIRS and dear to our heart... and brain.

PMID- 29842897
TI  - Clinical effects of low body mass index on geriatric status in elderly patients.
AB  - BACKGROUND: There is limited information on the relationship of low body mass
      index (BMI) to the geriatric conditions in elderly patients. OBJECTIVE: The
      objective of this study is to investigate whether low BMI associates with
      geriatric status in elderly patients by calculating suitable cut-off point of BMI
      for assessment of geriatric conditions. METHOD: A total of 1223 elderly patients
      was enrolled (male/female: N = 472/751), and cut-off point of the BMI values to
      assess the geriatric status such as aspiration pneumonia, cognitive impairment
      was determined by receiver operating characteristic (ROC) analyses. Logistic
      regression analyses were performed to examine the association between several
      geriatric status and low BMI. Of these patients, 262 patients (male/female:
      101/161) had received standard rehabilitation treatment. Functional Independence
      Measure (FIM) scores were measured both at admission and discharge to calculate
      FIM gain and efficiency, and retrospective cohort study was performed. RESULTS:
      Cut-off point of BMI value to assess the geriatric status was determined (19.0
      kg/m2). Significant associations of low BMI to several geriatric factors such as
      loss of posterior occlusion, cognitive impairment were observed in both male and
      female. FIM scores in above cut-off point group were significantly higher than in
      below cut-off point group in female (FIM gain, P = 0.0005; FIM efficiency, P =
      0.0025, Mann-Whitney U test). On the other hand, there were no significant
      differences between low and above BMI cut-off point in FIM scores of male
      patients. CONCLUSION: Low BMI might be a useful parameter to evaluate the
      geriatric status, and the viewpoint would contribute to decide the care plan for
      the good end-of-life of elderly.

PMID- 29842898
TI  - Novel murine model for delayed wound healing using a biological wound dressing
      with Pseudomonas aeruginosa biofilms.
AB  - Bacterial biofilms impair healing in 60% of chronic skin wounds. Various animal
      models (mice, rats, rabbits, and pigs) have been developed to replicate biofilm
      infected wounds in vivo. We developed a sustained wound infection model by
      applying preformed Pseudomonas aeruginosa biofilms on a wound dressing to full
      thickness murine skin wounds. We bathed a commercially available wound dressing
      in P. aeruginosa for 48 h, allowing a biofilm to establish on the dressing prior
      to application to the wound. Dressings were removed from the wounds after 3 days
      at which time the wound beds contained ~108 bacterial cells per gram tissue.
      Significant numbers of P. aeruginosa persisted within the skin wounds for up to
      21 days. Un-inoculated wounds reached closure between 9 and 12 days. In contrast,
      biofilm-inoculated wounds achieved closure between 18 and 21 days. Histologic
      analysis confirmed decreased re-epithelialization and collagen deposition,
      coupled with increased inflammation, in the biofilm-inoculated wounds compared to
      un-inoculated controls. This novel model of delayed healing and persistent
      infection of full-thickness murine skin wounds may provide a robust in vivo
      system in which to test novel treatments to prevent wound infection by bacterial
      biofilms.

PMID- 29842899
TI  - The Alzheimer's disease-associated TREM2 gene is regulated by p53 tumor
      suppressor protein.
AB  - TREM2 mutations evoke neurodegenerative disorders, and recently genetic variants
      of this gene were correlated to increased risk of Alzheimer's disease. The
      signaling cascade originating from the TREM2 membrane receptor includes its
      binding partner TYROBP, BLNK adapter protein, and SYK kinase, which can be
      activated by p53. Moreover, in silico identification of a putative p53 response
      element (RE) at the TREM2 promoter led us to hypothesize that TREM2 and other
      pathway elements may be regulated in p53-dependent manner. To stimulate p53 in
      synergistic fashion, we exposed A549 lung cancer cells to actinomycin D and
      nutlin-3a (A + N). In these cells, exposure to A + N triggered expression of
      TREM2, TYROBP, SYK and BLNK in p53-dependent manner. TREM2 was also activated by
      A + N in U-2 OS osteosarcoma and A375 melanoma cell lines. Interestingly, nutlin
      3a, a specific activator of p53, acting alone stimulated TREM2 in U-2 OS cells.
      Using in vitro mutagenesis, chromatin immunoprecipitation, and luciferase
      reporter assays, we confirmed the presence of the p53 RE in TREM2 promoter.
      Furthermore, activation of TREM2 and TYROBP by p53 was strongly inhibited by CHIR
      98014, a potent and specific inhibitor of glycogen synthase kinase-3 (GSK-3). We
      conclude that TREM2 is a direct p53-target gene, and that activation of TREM2 by
      A + N or nutlin-3a may be critically dependent on GSK-3 function.

PMID- 29842900
TI  - alpha-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt
      dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell
      line of amyotrophic lateral sclerosis.
AB  - Amyotrophic lateral sclerosis (ALS) is a degenerative disease with a progressive
      loss of motor neurons in the central nervous system (CNS). However, there are
      unsolved problems with the therapies for this disease. alpha-Lipoic acid (LA) is
      a natural, universal antioxidant capable of scavenging hydroxyl radicals as well
      as regenerating a series of antioxidant enzymes that has been widely used in
      clinical settings. This study aimed to evaluate the antioxidant and
      neuroprotective effects of LA in ALS cell and Drosophila models with mutant G85R
      and G93A hSOD1 genes. The biological effects of LA and the protein levels of
      several antioxidant factors were examined, as were those of phospho-Akt and
      phospho-ERK. Furthermore, specific inhibitors of the PI3K/Akt and MEK/ERK
      signaling pathways were used to analyze their effects on LA-induced antioxidant
      expression in vivo and in vitro. Evidences showed that the mutant hSOD1 resulted
      in the increased oxidative stress, abnormal antioxidant signaling and
      pathological behaviors in motor performance and survival compared with non-mutant
      hSOD1 models, treatment with LA improved motor activity and survival in
      transgenic flies, prevented NSC34 cells from mutant hSOD1 or H2O2 induced
      decreased antioxidant enzymes as well as increased ROS levels. In addition, LA
      regulated the expression levels of antioxidant proteins in a dose- and periodical
      time-dependent manner, which might be mediated by ERK/Akt pathway activation and
      independent from the mutant hSOD1 gene. Our observations suggest that LA exerts
      strong and positive antioxidant and neuroprotective effects through the
      activation of the ERK-Akt pathway in hSOD1 ALS models.

PMID- 29842901
TI  - MACS - a new SPM toolbox for model assessment, comparison and selection.
AB  - BACKGROUND: In cognitive neuroscience, functional magnetic resonance imaging
      (fMRI) data are widely analyzed using general linear models (GLMs). However,
      model quality of GLMs for fMRI is rarely assessed, in part due to the lack of
      formal measures for statistical model inference. NEW METHOD: We introduce a new
      SPM toolbox for model assessment, comparison and selection (MACS) of GLMs applied
      to fMRI data. MACS includes classical, information-theoretic and Bayesian methods
      of model assessment previously applied to GLMs for fMRI as well as recent
      methodological developments of model selection and model averaging in fMRI data
      analysis. RESULTS: The toolbox - which is freely available from GitHub - directly
      builds on the Statistical Parametric Mapping (SPM) software package and is easy
      to-use, general-purpose, modular, readable and extendable. We validate the
      toolbox by reproducing model selection and model averaging results from earlier
      publications. COMPARISON WITH EXISTING METHODS: A previous toolbox for model
      diagnosis in fMRI has been discontinued and other approaches to model comparison
      between GLMs have not been translated into reusable computational resources in
      the past. CONCLUSIONS: Increased attention on model quality will lead to lower
      false-positive rates in cognitive neuroscience and increased application of the
      MACS toolbox will increase the reproducibility of GLM analyses and is likely to
      increase the replicability of fMRI studies.

PMID- 29842902
TI  - The effect of surface treatments on dental zirconia: An analysis of biaxial
      flexural strength, surface roughness and phase transformation.
AB  - OBJECTIVES: This study investigates the effect of selected surface finishing
      techniques on the biaxial flexural strength, surface roughness and phase
      transformation of a zirconia dental restorative material. MATERIALS AND METHODS:
      Fully-sintered zirconia discs (?19.5 mm * 0.85 mm) were treated on one side with
      a single or a combination of the following treatments: diamond and/or tungsten
      carbide burs without water coolant in an air-turbine handpiece, air-particle
      abrasion, rubber-point polishing in a contra-angle handpiece, or no treatment
      (control). Biaxial flexural strength (BFS) (eleven groups, n = 10) was determined
      using a universal testing machine and surface roughness (thirteen groups, n = 6)
      was assessed using a profilometer. Results were analysed using one-way ANOVA and
      Student-Newman-Keuls Post-hoc test (alpha = 0.05) with Bonferroni correction.
      Specimens were observed under scanning electron microscopy (SEM) and x-ray
      diffraction (XRD) for their microstructure and crystalline phases respectively.
      RESULTS: Grinding with diamond burs did not weaken zirconia (p > 0.0045) but
      produced rougher surfaces than the control group (p < 0.0038). Tungsten-carbide
      burs smoothened diamond ground specimens (p < 0.0038) for both grits of diamond.
      Specimens ground by tungsten-carbide burs have significantly reduced mean BFS (p
      < 0.0045) by up to two-thirds and SEM revealed fine surface cracks. Air-particle
      abrasion restored the mean BFS of tungsten-carbide ground specimens to control
      levels (p > 0.0045) and surface cracks were not observed. Phase transformation
      was not detected by XRD. CONCLUSIONS: Dental zirconia ground dry with tungsten
      carbide burs has a significantly reduced BFS and a smooth but defective surface.
      These defects may be removed and BFS restored by air-particle abrasion. CLINICAL
      SIGNIFICANCE: The use of tungsten-carbide burs for grinding dental zirconia
      should be cautioned. Diamond grinding does not weaken zirconia but requires
      further polishing.

PMID- 29842903
TI  - A randomized, controlled trial of mindfulness-based stress reduction in HIV
      infection.
AB  - OBJECTIVE: Evidence links depression and stress to more rapid progression of HIV
      1 disease. We conducted a randomized controlled trial to test whether an
      intervention aimed at improving stress management and emotion regulation,
      mindfulness-based stress reduction (MBSR), would improve immunological (i.e. CD4+
      T-cell counts) and psychological outcomes in persons with HIV-1 infection.
      METHODS: We randomly assigned participants with HIV-1 infection and CD4 T-cell
      counts >350 cells/MUl who were not on antiretroviral therapy in a 1:1 ratio to
      either an MBSR group (n = 89) or an HIV disease self-management skills group (n =
      88). The study was conducted at the University of California at San Francisco. We
      assessed immunologic (CD4, c-reactive protein, IL-6, and d-dimer) and
      psychological measures (Beck Depression Inventory for depression, modified
      Differential Emotions Scale for positive and negative affect, Perceived stress
      scale, and mindfulness) at 3, 6 and 12 months after initiation of the
      intervention; we used multiple imputation to address missing values. RESULTS: We
      observed statistically significant improvements from baseline to 3-months within
      the MBSR group in depression, positive and negative affect, perceived stress, and
      mindfulness; between group differences in change were significantly greater in
      the MBSR group only for positive affect (per item difference on DES-positive
      0.25, 95% CI 0.049, 0.44, p = .015). By 12 months the between group difference in
      positive affect was not statistically significant, although both groups had
      trends toward improvements compared to baseline in several psychological outcomes
      that were maintained at 12-months; these improvements were only statistically
      significant for depression and negative affect in the MBSR group and perceived
      stress for the control group. The groups did not differ significantly on rates of
      antiretroviral therapy initiation (MBSR = 39%, control = 29%, p = .22). After 12
      months, the mean decrease in CD4+ T-cell count was 49.6 cells/MUl in participants
      in the MBSR arm, compared to 54.2 cells/MUl in the control group, a difference of
      4.6 cells favoring the MBSR group (95% CI, -44.6, 53.7, p = .85). The between
      group differences in other immunologic-related outcomes (c-reactive protein, IL
      6, HIV-1 viral load, and d-dimer) were not statistically significant at any time
      point. CONCLUSIONS: MBSR improved positive affect more than an active control arm
      in the 3 months following the start of the intervention. However, this difference
      was not maintained over the 12-month follow-up and there were no significant
      differences in immunologic outcomes between intervention groups. These results
      emphasize the need for further carefully designed research if we are to translate
      evidence linking psychological states to immunological outcomes into evidence
      based clinical practices.

PMID- 29842904
TI  - Molecular mechanisms underlying the neuroprotective role of atrial natriuretic
      peptide in experimental acute ischemic stroke.
AB  - Along with its role in regulating blood pressure and fluid homeostasis, the
      natriuretic peptide system could be also part of an endogenous protective
      mechanism against brain damage. We aimed to assess the possibility that exogenous
      atrial natriuretic peptide (ANP) could protect against acute ischemic stroke, as
      well as the molecular mechanisms involved. Three groups of rats subjected to
      transient middle cerebral artery occlusion (tMCAO, intraluminal filament
      technique, 60 min) received intracerebroventricular vehicle, low-dose ANP (0.5
      nmol) or high-dose ANP (2.5 nmol), at 30 min reperfusion. Neurofunctional
      condition, and brain infarct and edema volumes were measured at 24 h after tMCAO.
      Apoptotic cell death and expression of natriuretic peptide receptors (NPR-A and
      NPR-C), K+ channels (KATP, KV and BKCa), and PI3K/Akt and MAPK/ERK1/2 signaling
      pathways were analyzed. Significant improvement in neurofunctional status,
      associated to reduction in infarct and edema volumes, was shown in the high-dose
      ANP group. As to the molecular mechanisms analyzed, high-dose ANP: 1) reduced
      caspase-3-mediated apoptosis; 2) did not modify the expression of NPR-A and NPR
      C, which had been downregulated by the ischemic insult; 3) induced a significant
      reversion of ischemia-downregulated KATP channel expression; and 4) induced a
      significant reversion of ischemia-upregulated pERK2/ERK2 expression ratio. In
      conclusion, ANP exerts a significant protective role in terms of both improvement
      of neurofunctional status and reduction in infarct volume. Modulation of ANP on
      some molecular mechanisms involved in ischemia-induced apoptotic cell death (KATP
      channels and MAPK/ERK1/2 signaling pathway) could account, at least in part, for
      its beneficial effect. Therefore, ANP should be considered as a potential
      adjunctive neuroprotective agent improving stroke outcome after successful
      reperfusion interventions.

PMID- 29842905
TI  - Investigating the role of the human CIA2A-CIAO1 complex in the maturation of
      aconitase.
AB  - BACKGROUND: The CIA2A protein, in complex with CIAO1, has been proposed to be
      exclusively implicated in the maturation of cytosolic aconitase. However, how the
      CIA2A-CIAO1 complex generates active aconitase is still unknown and the available
      structural information has not provided any crucial insights into the molecular
      function of CIA2A. METHODS: In this work we have characterized the Fe/S cluster
      binding properties of CIA2A and of the CIA2A-CIAO1 complex via NMR, UV - vis
      absorption and EPR spectroscopies and we have investigated how the Fe/S cluster
      is transferred to inactive aconitase/IRP1 protein. RESULTS: We found that an
      heterotrimeric species formed by two molecules of CIA2A and one of CIAO1 can bind
      one [4Fe-4S] cluster and that residue Cys90 of CIA2A is one of the cluster
      ligand. The holo trimeric complex is able to transfer the [4Fe-4S] cluster to apo
      IRP1 thus generating the active form of aconitase. CONCLUSIONS AND GENERAL
      SIGNIFICANCE: These findings, which highlight a functional role for CIA2A-CIAO1
      complex in aconitase maturation, raises a broad interest and can have a high
      impact on the community studying metal trafficking and iron-sulfur protein
      biogenesis. The present study can provide solid bases for further investigation
      of the molecular mechanisms involving also other CIA machinery proteins.

PMID- 29842906
TI  - The phosphatidic acid paradox: Too many actions for one molecule class? Lessons
      from plants.
AB  - Phosphatidic acid (PA) is a simple phospholipid observed in most organisms. PA
      acts as a key metabolic intermediate and a second messenger that regulates many
      cell activities. In plants, PA is involved in numerous cell responses induced by
      hormones, stress inputs and developmental processes. Interestingly, PA production
      can be triggered by opposite stressors, such as cold and heat, or by hormones
      that are considered to be antagonistic, such as abscisic acid and salicylic acid.
      This property questions the specificity of the responses controlled by PA. Are
      there generic responses to PA, meaning that cell regulation triggered by PA would
      be always the same, even in opposite physiological situations? Alternatively, do
      the responses to PA differ according to the physiological context within the
      cells? If so, the mechanisms that regulate the divergence of PA-controlled
      reactions are poorly defined. This review summarizes the latest opinions on how
      PA signalling is directed in plant cells and examines the intrinsic properties of
      PA that enable its regulatory diversity. We propose a concept whereby PA
      regulatory messages are perceived as complex "signatures" that take into account
      their production site, the availability of target proteins and the relevant
      cellular environments.

PMID- 29842907
TI  - Sterigmatocystin: A mycotoxin to be seriously considered.
AB  - Sterigmatocystin is a carcinogenic compound that affects several species of crops
      and several species of experimental animals. The sterigmatocystin biosynthetic
      pathway is the best known and most studied. The International Agency for Research
      on Cancer classifies sterigmatocystin in the Group 2B. Three groups of analytical
      methods to determine sterigmatocystin in food can be found: chromatographic,
      ELISA immunoassays and chemical sensors. In addition, sterigmatocystin is a
      precursor of aflatoxin B1 in those cases where cereals and/or food are
      contaminated with fungi capable of producing aflatoxins. Chemical structures of
      sterigmatocystin and aflatoxin B1 are similar. These mycotoxins are pathogens of
      animals and cereals, producing a major economic impact on biotechnology and
      agricultural and food industries. This review summarizes different aspects
      related to sterigmatocystin such as its biosynthesis, toxicological studies and
      analytical methods for its determination.

PMID- 29842908
TI  - Parameters affecting the exposure to furfuryl alcohol from coffee.
AB  - Recently, furfuryl alcohol (FFA) was labelled a human potential carcinogen (group
      2B) by the International Agency for Research on Cancer. Its alimentary exposure
      is mostly from coffee since in any other foods the concentrations are
      significantly lower. The various storage conditions of roasted coffee, the
      different brewing techniques applied and the bioaccessibility after ingestion are
      potential parameters that might alter the exposure to FFA from coffee. An 8 weeks
      stability study at varying temperatures showed that FFA is stable in the ground
      coffee matrix. Moreover, different brewing techniques extracted different amounts
      of FFA and affected its final concentration. The evaluation of the relative
      exposure to four furans (FFA, 5-hydroxymethyl-furaldehyde, 2-furoic acid, and 5
      hydroxymethyl-2-furoic acid) revealed that FFA amounts were at least 2-fold the
      amounts of other studied furans in the same brew. A 22-fold variation in the
      concentration of the four furans in brews prepared using different coffee grounds
      and brewing techniques could be observed. 90% of the four furans were extracted
      by the first 25-30% fraction of the filter brew. A significant decrease of FFA is
      observed after stressing with simulated gastric fluid. However, this decrease
      could not be reproduced when mimicking a regular coffee ingestion situation.

PMID- 29842909
TI  - Editorial: Alternative tobacco products: Toxicology and health issues.

PMID- 29842910
TI  - Activation of the p53 pathway with digiferrol isolated from Rubia philippinensis
      induces cell cycle arrest, apoptosis, and autophagy in colon cancer cells.

PMID- 29842911
TI  - Identification and characterization of chitin deacetylase2 from the American
      white moth, Hyphantria cunea (Drury).
AB  - Chitin deacetylases (CDAs) are enzymes that catalyze the conversion of chitin
      into chitosan, thereby influence the mechanical and permeability properties of
      structures such as the cuticle and peritrophic matrices. The full length cDNAs of
      chitin deacetylase2 (CDA2) genes from Hyphantria cunea were fully cloned by PCR
      amplification. Two cDNA sequences of HcCDA2 were searched from transcriptome of
      H. cunea and named as HcCDA2a and HcCDA2b. The deduced protein sequences showed
      that HaCDA2a and HaCDA2b are synthesized as preproteins of 524 and 518 amino acid
      residues with an 18-amino acid signal peptide, respectively. HcCDA2a and HcCDA2b
      contained a chitin-binding domain (ChBD), a low-density lipoprotein receptor
      class A domain (LDLa) and a polysaccharide deacetylase-like catalytic domain
      (CDA). Gene expression analyses results showed that HcCDA2a and HcCDA2b were both
      expressed at the head, integument, foregut, midgut, hindgut, Malpighian tubules
      and fat body, as well as the 1st to 5th days of fifth instar larvae. Western blot
      analyses revealed that HcCDA2 protein was highly abundant in the head and
      integument, and the developmental expression result in the fifth instars showed
      that HcCDA2 was highly present at the first two days. Besides, RT-PCR results
      showed that HcCDA2a and HcCDA2b were both expressed in integument and head,
      whether in molting stage or feeding stage. No visiable phenotypic changes were
      observed after injection of dsHcCDA2b, while lethal phenotypes of cuticle
      shedding failure and high mortality were resulted from injection of dsHcCDA2a.
      The silence of HcCDA2a leads to the ecdysis failure and death of H. cunea. These
      results suggest that HcCDA2 plays an important role during insect development,
      and provide new candidate targets and basis for developing environment-friendly
      pesticides.

PMID- 29842912
TI  - Associations of interleukin-6 gene polymorphisms with cancer risk: Evidence based
      on 49,408 cancer cases and 61,790 controls.
AB  - Many molecular epidemiologic studies have shown that interleukin-6 (IL-6)
      polymorphisms are significantly associated with susceptibility for various
      cancers. However, the conclusions of these studies are inconsistent. The purpose
      of the present study was to explore the association between three common IL-6
      loci (rs1800795, rs1800796, and rs1800797) and the risk for various cancers. We
      systematically searched the PubMed, Web of Science, Wanfang and China national
      knowledge infrastructure (CNKI) databases for relevant publications and obtained
      108 eligible studies, involving 49,408 cancer patients and 61,790 cancer-free
      controls. Odds ratio (OR), 95% confidence interval (CI), and false positive
      reporting probability (FPRP) were used to evaluate cancer risk. All statistical
      analyses were performed using the R software meta package. We observed a non
      significant association between rs1800795 and overall cancer risk, while
      rs1800797 was found to have a false positive association with overall risk of
      cancer. Subgroup analyses of rs1800797 also suggested non-significant association
      and rs1800795 played a protective role in liver cancer. Rs1800796 was found to be
      associated with overall cancer risk, particularly in Asian patients and those
      with prostate cancer. These findings provide evidence that IL-6 polymorphisms may
      affect cancer risk.

PMID- 29842913
TI  - Baculovirus for gene delivery to mammalian cells: Past, present and future.
AB  - Baculovirus is an insect virus which has been used for more than thirty years for
      production of recombinant proteins in insect cells. However, baculovirus can also
      be harnessed for efficient gene delivery to mammalian cells if it is equipped
      with mammalian promoters. This technology is known as BacMam and has been used
      for gene delivery to immortalized cell lines, stem cells, and primary cells, as
      well as for gene delivery in animals. Baculovirus has unique features when
      compared to mammalian viruses. Besides the fact that it is replication
      incompetent and does not integrate into the host genome, it has large capacity
      for foreign DNA. This capacity can for example be used to deliver multiple genes
      for reprogramming of stem cells, or for delivery of large homology constructs for
      genome editing. In this review, we provide a brief overview of baculovirus-based
      gene delivery and its recent applications in therapy and basic research. We also
      describe how baculovirus is manipulated for efficient transduction in mammalian
      cells and we highlight possible future improvements.

PMID- 29842914
TI  - Genetic diversity of the human adenovirus species C DNA polymerase.
AB  - BACKGROUND: Human Adenovirus (HAdV) are responsible for severe infections in
      hematopoietic stem cells transplant (HSCT) recipient, species C viruses being the
      most commonly observed in this population. There is no approved antiviral
      treatment yet. Cidofovir (CDV), a cytidine analog, is the most frequently used
      and its lipophilic conjugate, brincidofovir (BCV), is under clinical development.
      These drugs target the viral DNA polymerase (DNA pol). Little is known about the
      natural polymorphism of HAdV DNA pol in clinical strains. METHODS: We assessed
      the inter- and intra-species variability of the whole gene coding for HAdV DNA
      pol of HAdV clinical strains of species C. The study included 60 species C HAdV
      (21 C1, 27 C2 and 12 C5) strains isolated from patients with symptomatic
      infections who had never experienced CDV or BCV treatments and 20 reference
      strains. We also evaluated the emergence of mutations in thrirteen patients with
      persistent HAdV infection despite antiviral treatment. RESULTS: We identified 356
      polymorphic nucleotide positions (9.9% of the whole gene), including 102
      positions with nonsynonymous mutations (28.0%) representing 8.7% of all amino
      acids. The mean numbers of nucleotide and amino acid mutations per strain were
      23.1 (+/-6.2) and 5.2 (+/-2.4) respectively. Most of amino acid substitutions
      (60.6%) were observed in one instance only. A minority (13.8%) were observed in
      more than 10% of all strains. The most variable region was the NH2 terminal
      domain (44.2% of amino acid mutations). Mutations in the exonuclease domain
      accounted for 27.8%. The binding domains for the terminal protein (TPR), TPR1 and
      TPR2, presented a limited number of mutations, which were nonetheless frequently
      observed (62.5% and 58.8% of strains for TPR1 and TPR2, respectively). None of
      the mutations associated with CDV or BCV resistance were detected. In patients
      receieving antiviral drugs with persistent HAdV replication, we identified a new
      mutation in the NH2 terminal region. CONCLUSIONS: Our study shows a high
      diversity in HAdV DNA pol sequences in clinical species C HAdV and provides a
      comprehensive mapping of its natural polymorphism. These data will contribute to
      the interpretation of HAdV DNA pol mutations selected in patients receiving
      antiviral treatments.

PMID- 29842915
TI  - Cathodal transcranial direct current stimulation over right dorsolateral
      prefrontal cortex improves language control during language switching.
AB  - Currently, there is increasing attention on how to best improve language control
      efficiency and minimize cross-language interference in bilinguals. Previous
      studies have demonstrated that right dorsolateral prefrontal cortex (rDLPFC)
      plays an important role in inhibiting unrelated stimuli. The current study
      applied transcranial direct current stimulation (tDCS) during language switching
      to determine whether modulation of rDLPFC would affect language control
      mechanisms. All the participants have undergone three types of stimulations:
      cathodal stimulation, anodal stimulation and sham stimulation. The sequence of
      three stimulations was counterbalanced across participants. After each
      stimulation, participants performed picture naming task for language switching.
      Unbalanced bilinguals exhibited a larger late positive component (LPC) in
      switching to the weaker language than to the dominant one and similar L1 and L2
      switch costs only in the cathodal tDCS (C-tDCS) session. Further analyses showed
      that the differences of switch costs (L1 switch costs - L2 switch costs) in the C
      tDCS session were smaller than in the sham-tDCS (S-tDCS) session. Results were
      largely consistent with the assumption that cathodal stimulation improving
      inhibitory control abilities of unbalanced bilinguals to help them better inhibit
      interference. Another possibility is that cathodal stimulation also worked in
      other brain areas (e.g., supplementary motor area), which potentially altered
      unbalanced bilinguals' speech planning or abilities to encode task sets.

PMID- 29842916
TI  - High fat diet feeding induced insulin resistance exacerbates 6-OHDA mediated
      neurotoxicity and behavioral abnormalities in rats.
AB  - Some of the clinical reports suggest that insulin resistance could be a risk
      factor for Parkinson's disease (PD) development, however experimental data is
      scarce. Our previous work has suggested that insulin resistance could be an
      important factor that leads to diabetes associated neurodegeneration. In the
      present study, we evaluated whether insulin resistance is linked to PD pathology
      or not. For this purpose, we first standardized an animal model which could mimic
      the co-morbid insulin resistance and PD condition. For development of insulin
      resistance, we fed the male Wistar rats with high fat diet (HFD) for eight weeks,
      followed by 6-hydroxydopamine (6-OHDA) administration, a toxin widely used for PD
      induction, in medial forebrain bundle (MFB) of rats. The 6-OHDA treatment
      resulted in neuronal damage and loss of striatal dopamine level. This dopamine
      loss was correlated with impaired performance in behavioral tasks such as
      rotarod, narrow beam walk test and locomotor activity. Interestingly, we found
      that exposure to HFD exacerbated the effects of 6-OHDA on striatal dopamine loss
      and behavioral parameters in rats, indicating that HFD-induced insulin resistance
      is associated with a diminished capacity of dopaminergic neurons to cope with 6
      OHDA mediated neurotoxicity. Based upon these findings, it can be suggested that
      HFD feeding induced insulin resistance exacerbates the PD pathology.

PMID- 29842917
TI  - Therapeutic targeting of cathepsin C: from pathophysiology to treatment.
AB  - Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl
      aminopeptidase. The best characterized physiological function of CatC is the
      activation of pro-inflammatory granule-associated serine proteases. These
      proteases are synthesized as inactive zymogens containing an N-terminal pro
      dipeptide, which maintains the zymogen in its inactive conformation and prevents
      premature activation, which is potentially toxic to the cell. The activation of
      serine protease zymogens occurs through cleavage of the N-terminal dipeptide by
      CatC during cell maturation in the bone marrow. In vivo data suggest that
      pharmacological inhibition of pro-inflammatory serine proteases would suppress or
      attenuate deleterious effects mediated by these proteases in inflammatory/auto
      immune disorders. The pathological deficiency in CatC is associated with Papillon
      Lefevre syndrome (PLS). The patients however do not present marked
      immunodeficiency despite the absence of active serine proteases in immune defense
      cells. Hence, the transitory pharmacological blockade of CatC activity in the
      precursor cells of the bone marrow may represent an attractive therapeutic
      strategy to regulate activity of serine proteases in inflammatory and immunologic
      conditions. A variety of CatC inhibitors have been developed both by
      pharmaceutical companies and academic investigators, some of which are currently
      being employed and evaluated in preclinical/clinical trials.

PMID- 29842918
TI  - Intra-articular clearance of labeled dextrans from naive and arthritic rat knee
      joints.
AB  - OBJECTIVE: Determine the effects of arthritis on the trans-synovial clearance of
      small and large model compounds following local delivery to the knee joint in a
      rat model. DESIGN: Intra-articular delivery was studied in rat knee joints in an
      osteoarthritis model of joint instability (medial collateral ligament and
      meniscus transection model or MMT). Fluorescently-labeled 10 kDa or 500 kDa
      dextran was injected in the arthritic or unoperated control (naive) joints 3
      weeks after surgical destabilization, and the temporal clearance pattern was
      evaluated via in vivo regional fluorescence imaging, dextran concentrations in
      plasma and draining lymph nodes, and by quantification of fluorescence in
      histological synovium sections. Together these data were used to evaluate the
      effect of osteoarthritis and solute size on the rate of drug clearance from the
      joint. RESULTS: Clearance of 10 kDa dextran from the joint space quantified using
      in vivo fluorescence imaging of the knee joint region was not significantly
      different between naive and MMT joints. In contrast, clearance of 500 kDa dextran
      was significantly reduced for MMT joints when compared to naive joints by
      fluorescence in vivo imaging. Drug accumulation in lymph nodes and plasma were
      lower for the 500 kDa dextran as compared to 10 kDa dextran, and lymph node
      levels were further reduced with the presence of osteoarthritis. Furthermore,
      synovium was significantly thicker in MMT joints than in naive joints and image
      analysis of joint tissue sections revealed different trans-synovial distributions
      of 10 and 500 kDa dextran. CONCLUSION: Large macromolecules were retained in the
      arthritic joint longer than in the healthy joint, while smaller molecules were
      cleared similarly in healthy and arthritic joints. In vivo fluorescence imaging,
      plasma and lymph node concentrations, and spatial distributions of drug
      fluorescence identified differences in higher molecular weight clearance between
      naive and arthritic disease states. Findings may relate to a thickening of
      synovium for joints with induced arthritis, and support the concept that intra
      articular drug delivery effectiveness may vary with the state of joint pathology.

PMID- 29842919
TI  - Sustained therapeutic efficacy of budesonide-loaded chitosan swellable
      microparticles after lung delivery: Influence of in vitro release, treatment
      interval and dose.
AB  - Sustained drug delivery to the respiratory tract is highly desirable for local
      treatment of chronic lung diseases. In this context, a correlation of in vitro
      drug release with in vivo efficacy data is essential to accelerate the
      application of sustained drug delivery system for inhalation into the clinical
      setting. In this study, budesonide was incorporated into distinct chitosan-based
      swellable microparticles, which were characterized, and the in vitro drug release
      behavior determined. The particles were then given to an allergic asthma animal
      model as single and successive administrations, and the therapeutic response was
      determined by measuring cell counts, IL-4 and IL-5 levels in bronchoalveolar
      lavage fluid, IL-4 and IL-5 mRNA in the lung and by histopathologic examination
      of lung tissues. After a single administration, the time-dependent therapeutic
      effect of the swellable microparticles was correlated with the in vitro release
      behavior, which lasted for 12 or 18 h depending on the molecular weight of the
      chitosan. After seven days of successive treatment, the number of eosinophils
      decreased further and IL-4 and IL-5 mRNA expression in the lung tissue was more
      greatly inhibited. Moreover, the chitosan-based swellable microparticles allowed
      longer administration intervals (every two days), which decreased the required
      dose for effectiveness by 50%. These results demonstrate that chitosan-based
      swellable microparticles can sustain the therapeutic effect of budesonide in the
      respiratory tract which in principal can be applied to other drugs for the
      treatment of local lung diseases.

PMID- 29842920
TI  - Could a tax on unhealthy products sold for weight loss reduce consumer use? A
      novel estimation of potential taxation effects.
AB  - Abuse of widely available, over-the-counter (OTC) drugs and supplements such as
      diet pills, laxatives, and diuretics by adolescents for weight control is well
      documented, yet manufacturers and retailers can sell them to minors without
      restriction. The aim of our study was to estimate the effect of added taxation of
      OTC drugs and dietary supplements sold for weight loss on household purchases of
      these products. With data from 60,538 U.S. households in the 2012 waves of the
      Nielsen/IRi National Consumer Panel (NCP) and the Nielsen/IRi Retail Scanner
      (NRS) datasets, we conducted analyses in 2017 to tally annual quantities and
      expenditures on OTC drugs or dietary supplements making weight-loss,
      cleanse/detox, or diuretic claims. We estimated the percent reduction in
      household purchases due to a simulated 20% added tax on each category. Among the
      14,151 households reporting at least one purchase in the three claims categories,
      a 20% higher average price of weight-loss products was associated with a 5.2%
      lower purchases of those products. Among households with children ages 12 to 17
      years old present, purchases were 17.5% lower, and among households with a
      daughter present, purchases were 10.3% lower. Taxation may be an effective public
      health strategy to reduce purchasing of potentially dangerous OTC drugs and
      supplements sold for weight loss, especially for households that include children
      ages 12-17 years old or a daughter.

PMID- 29842921
TI  - Anatomy of rodent and human livers: What are the differences?
AB  - The size of the liver of terrestrial mammals obeys the allometric scaling law
      over a weight range of >3 * 106. Since scaling reflects adaptive changes in size
      or scale among otherwise similar animals, we can expect to observe more
      similarities than differences between rodent and human livers. Obvious
      differences, such as the presence (rodents) or absence (humans) of lobation and
      the presence (mice, humans) or absence (rats) of a gallbladder, suggest
      qualitative differences between the livers of these species. After review,
      however, we conclude that these dissimilarities represent relatively small
      quantitative differences. The microarchitecture of the liver is very similar
      among mammalian species and best represented by the lobular concept, with the
      biggest difference present in the degree of connective tissue development in the
      portal tracts. Although larger mammals have larger lobules, increasing size of
      the liver is mainly accomplished by increasing the number of lobules. The
      increasing role of the hepatic artery in lobular perfusion of larger species is,
      perhaps, the most important and least known difference between small and large
      livers, because it profoundly affects not only interventions like liver
      transplantations, but also calculations of liver function.

PMID- 29842922
TI  - MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing
      Mfn2-dependent mitochondrial fusion via activation of PGC-1alpha.
AB  - Parkinson's disease (PD) is characterized by the degeneration of dopaminergic
      neurons in the substantia nigra compacta (SNc). Although mitochondrial
      dysfunction is the critical factor in the pathogenesis of PD, the underlying
      molecular mechanisms are not well understood, and as a result, effective medical
      interventions are lacking. Mitochondrial fission and fusion play important roles
      in the maintenance of mitochondrial function and cell viability. Here, we
      investigated the effects of MitoQ, a mitochondria-targeted antioxidant, in 6
      hydroxydopamine (6-OHDA)-induced in vitro and in vivo PD models. We observed that
      6-OHDA enhanced mitochondrial fission by decreasing the expression of Mfn1, Mfn2
      and OPA1 as well as by increasing the expression of Drp1 in the dopaminergic (DA)
      cell line SN4741. Notably, MitoQ treatment particularly upregulated the Mfn2
      protein and mRNA levels and promoted mitochondrial fusion in the presence of 6
      OHDA in a Mfn2-dependent manner. In addition, MitoQ also stabilized mitochondrial
      morphology and function in the presence of 6-OHDA, which further suppressed the
      formation of reactive oxygen species (ROS), as well as ameliorated mitochondrial
      fragmentation and cellular apoptosis. Moreover, the activation of peroxisome
      proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) was
      attributed to the upregulation of Mfn2 induced by MitoQ. Consistent with these
      findings, administration of MitoQ in 6-OHDA-treated mice significantly rescued
      the decrease of Mfn2 expression and the loss of DA neurons in the SNc. Taken
      together, our findings suggest that MitoQ protects DA neurons in a 6-OHDA induced
      PD model by activating PGC-1alpha to enhance Mfn2-dependent mitochondrial fusion.

PMID- 29842924
TI  - Quality Improvement Initiative to Improve Human Papillomavirus Vaccine Initiation
      at 9 Years of Age.
AB  - OBJECTIVE: Adolescent human papillomavirus (HPV) vaccine rates remain low. Early
      vaccination may improve the efficacy of the vaccine and immunization rates;
      however, clinicians have not routinely made a strong recommendation for younger
      adolescents. This study assessed the feasibility of routine vaccination at 9
      years of age. METHODS: Three sequential quality improvement (QI) interventions
      were implemented to shift the initiation of the HPV vaccine to 9 years of age in
      a primary care network in low-income neighborhoods in Columbus, Ohio. The first
      intervention changed the electronic medical record alert for the HPV vaccine from
      11 to 9 years of age and focused on cancer prevention when discussing the vaccine
      with families. The second intervention was formation of an HPV QI team. The third
      intervention was a clinic incentive for HPV captured opportunity rates.
      Immunization rates were monitored using statistical process control charts to
      compare the HPV immunization rate in a sample of 9- and 10-year-old children with
      a sample of 11- and 12-year-old children. RESULTS: The percentage of patients
      receiving an HPV vaccine before 11 years increased from 4.6% to 35.7% during the
      6 months after the QI initiative began and to 60.8% 18 months after the project
      began. In comparison, the HPV vaccination rate in the sample of 11- and 12-year
      olds increased from 78.7% to 82.8% 18 months later. CONCLUSIONS: This QI project
      used multiple interventions to increase HPV vaccination at 9 years of age in a
      large primary care network serving a diverse low-income population.

PMID- 29842923
TI  - Antibacterial, antifungal, anticancer activities and structural bioinformatics
      analysis of six naturally occurring temporins.
AB  - Antimicrobial peptides are a special class of natural products with potential
      applications as novel therapeutics. This study focuses on six temporins (four
      with no activity data and two as positive controls). Using synthetic peptides, we
      report antibacterial, antifungal, and anticancer activities of temporins-CPa,
      CPb, 1Ga, 1Oc, 1Ola, and 1SPa. While temporin-1Ga and temporin-1OLa showed higher
      antifungal and anticancer activity, most of these peptides were active primarily
      against Gram-positive bacteria. Temporin-1OLa, with the highest cell selectivity
      index, could preferentially kill methicillin-resistant Staphylococcus aureus
      (MRSA), consistent with a reduced hemolysis in the presence of bacteria.
      Mechanistically, temporin-1OLa rapidly killed MRSA by damaging bacterial
      membranes. Using micelles as a membrane-mimetic model, we determined the three
      dimensional structure of temporin-1OLa by NMR spectroscopy. The peptide adopted a
      two-domain structure where a hydrophobic patch is followed by a classic
      amphipathic helix covering residues P3-I12. Such a structure is responsible for
      anti-biofilm ability in vitro and in vivo protection of wax moths Galleria
      mellonella from staphylococcal infection. Finally, our bioinformatic analysis
      leads to a classification of temporins into six types and confers significance to
      this NMR structure since temporin-1OLa shares a sequence model with 62% of
      temporins. Collectively, our results indicate the potential of temporin-1OLa as a
      new anti-MRSA compound, which shows an even better anti-biofilm capability in
      combination with linezolid.

PMID- 29842925
TI  - Adaptation to the coupling of glycolysis to toxic methylglyoxal production in
      tpiA deletion strains of Escherichia coli requires synchronized and
      counterintuitive genetic changes.
AB  - Methylglyoxal is a highly toxic metabolite that can be produced in all living
      organisms. Methylglyoxal was artificially elevated by removal of the tpiA gene
      from a growth optimized Escherichia coli strain. The initial response to elevated
      methylglyoxal and its toxicity was characterized, and detoxification mechanisms
      were studied using adaptive laboratory evolution. We found that: 1) Multi-omics
      analysis revealed biological consequences of methylglyoxal toxicity, which
      included attack on macromolecules including DNA and RNA and perturbation of
      nucleotide levels; 2) Counter-intuitive cross-talk between carbon starvation and
      inorganic phosphate signalling was revealed in the tpiA deletion strain that
      required mutations in inorganic phosphate signalling mechanisms to alleviate; and
      3) The split flux through lower glycolysis depleted glycolytic intermediates
      requiring a host of synchronized and coordinated mutations in non-intuitive
      network locations in order to re-adjust the metabolic flux map to achieve optimal
      growth. Such mutations included a systematic inactivation of the
      Phosphotransferase System (PTS) and alterations in cell wall biosynthesis enzyme
      activity. This study demonstrated that deletion of major metabolic genes followed
      by ALE was a productive approach to gain novel insight into the systems biology
      underlying optimal phenotypic states.

PMID- 29842926
TI  - Facile assembly and fluorescence-based screening method for heterologous
      expression of biosynthetic pathways in fungi.
AB  - Heterologous expression of multi-gene biosynthetic pathways in eukaryotic hosts
      is limited by highly regulated individual monocistrons. Dissimilar to
      prokaryotes, each eukaryotic gene is strictly controlled by its own regulatory
      elements, such as promoter and terminator. Consequently, parallel transcription
      can occur only when a group of genes is synchronously activated. A strategy to
      circumvent this limitation is the concerted expression of multiple genes as a
      polycistron. By exploiting the "stop-carry on" mechanism of picornaviruses, we
      have designed a sophisticated, yet easy-to-assemble vector system to
      heterologously express multiple genes under the control of a single promoter. For
      facile selection of correctly transformed colonies by basic fluorescence
      microscopy, our vector includes a split gene for a fluorescent reporter protein.
      This method was successfully applied to produce the psychotropic mushroom
      alkaloid psilocybin in high yields by heterologous expression of the entire
      biosynthetic gene cluster in the mould Aspergillus nidulans.

PMID- 29842927
TI  - Endothelial progenitor cells and rheumatic disease modifying therapy.
AB  - Rheumatic diseases are associated with accelerated atherosclerosis and with
      increased risk of cardiovascular morbidity and mortality. The mechanisms
      underlying the higher prevalence of cardiovascular disease are not completely
      clarified, but it is likely that a pivotal role is played by vascular
      inflammation and consequently to altered vascular endothelium homeostasis. Also,
      high prevalence of traditional risk factors, proatherogenic activation and
      endothelial dysfunction further contribute to vascular damage. Circulating
      endothelial progenitor cells (EPCs) can restore dysfunctional endothelium and
      protect against atherosclerotic vascular disease. However, abnormalities in
      number and function of these cells in patients with rheumatic condition have been
      extensively reported. During the last years, growing interest in the mechanisms
      of endothelial renewal and its potential as a therapy for CVD has been shown; in
      addition, pioneering studies show that EPC dysfunction might be improved with
      pharmacological strategies. However, how to restore EPC function, and whether
      achieving this aim may be effective in preventing cardiovascular complications in
      rheumatic disease, remain to be established. In this review we report an overview
      on the current stand of knowledge on the effect of pharmaceutical and lifestyle
      intervention in improving EPCs number and function in rheumatic disease.

PMID- 29842928
TI  - HPV E6 oncoproteins and nucleic acids in neck lymph node fine needle aspirates
      and oral samples from patients with oropharyngeal squamous cell carcinoma.
AB  - Commercial assays measuring HPV E6 viral oncoproteins, E6/E7 mRNA or DNA were
      used to test neck lymph node fine needle aspirates (FNA) and oropharyngeal
      samples (saliva and oral swabs) from 59 Canadian patients with oropharyngeal
      squamous cell carcinomas (OPSCC). Overall agreements of p16 antigen staining of
      tumors to FNA tested for OncoE6TM, Aptima HPV E6/E7 mRNA and cobas HPV DNA were
      81.4% (k 0.53), 94.9% (k 0.83) and 91.1% (k 0.73) respectively. Using HPV
      presence in a subset of 25 tumors as the comparator, overall agreement was 64.0%
      (k 0.08) with OncoE6TM, 88.0% (k 0.65) with Aptima HPV E6/E7 mRNA and 91.7% (k
      0.70) with cobas HPV DNA. HPV testing of oropharyngeal samples yielded lower
      agreements with tumor markers; 23.7-24.0% (k 0.02), 55.9-68.0% (k 0.24-0.37) and
      78.9-86.9% (k 0.49-0.58) in the 3 respective tests. HPV 16 was present in 93.7
      100% of the samples tested and showed 100% genotype agreement between FNA and
      tumors. The high rates for HPV E6 oncoproteins and E6/E7 mRNA suggests most
      patients were experiencing transcriptionally active HPV-related OPSCC. Results
      from these commercial assays performed on FNA but not oropharyngeal samples
      showed moderate to very good agreements with p16 and HPV testing of tumors.

PMID- 29842929
TI  - Antagonism of Transcription Factor MYC2 by EDS1/PAD4 Complexes Bolsters Salicylic
      Acid Defense in Arabidopsis Effector-Triggered Immunity.
AB  - In plant immunity, pathogen-activated intracellular nucleotide binding/leucine
      rich repeat (NLR) receptors mobilize disease resistance pathways, but the
      downstream signaling mechanisms remain obscure. Enhanced disease susceptibility 1
      (EDS1) controls transcriptional reprogramming in resistance triggered by Toll
      Interleukin1-Receptor domain (TIR)-family NLRs (TNLs). Transcriptional induction
      of the salicylic acid (SA) hormone defense sector provides one crucial barrier
      against biotrophic pathogens. Here, we present genetic and molecular evidence
      that in Arabidopsis an EDS1 complex with its partner PAD4 inhibits MYC2, a master
      regulator of SA-antagonizing jasmonic acid (JA) hormone pathways. In the TNL
      immune response, EDS1/PAD4 interference with MYC2 boosts the SA defense sector
      independently of EDS1-induced SA synthesis, thereby effectively blocking actions
      of a potent bacterial JA mimic, coronatine (COR). We show that antagonism of MYC2
      occurs after COR has been sensed inside the nucleus but before or coincident with
      MYC2 binding to a target promoter, pANAC019. The stable interaction of PAD4 with
      MYC2 in planta is competed by EDS1-PAD4 complexes. However, suppression of MYC2
      promoted genes requires EDS1 together with PAD4, pointing to an essential EDS1
      PAD4 heterodimer activity in MYC2 inhibition. Taken together, these results
      uncover an immune receptor signaling circuit that intersects with hormone pathway
      crosstalk to reduce bacterial pathogen growth.

PMID- 29842930
TI  - FmLC6: An ultimate dual-CRD C-type lectin from Fenneropenaeus merguiensis
      mediated its roles in shrimp defense immunity towards bacteria and virus.
AB  - C-type lectins are a member of pattern recognition receptors (PRRs) that can
      interact with pathogen-associated molecular patterns of invading microorganisms
      by using their conserved motifs in carbohydrate recognition domain (CRD). The
      binding can trigger various immune responses in both direct and indirect
      mechanisms. Hereby, an ultimate C-type lectin with dual CRDs each of which
      containing a different motif was identified from hepatopancreas of Fenneropenaeus
      merguiensis (mentioned as FmLC6). The full-length cDNA of FmLC6 consisted of 1148
      bp comprising one 1005 bp open reading frame (ORF) encoding a signal peptide and
      a mature protein of 317 residues. FmLC6 was composed of two CRDs with a highly
      conserved QPD (Gln-Pro-Asp) motif and one variant EPQ (Glu-Pro-Gln) motif for
      illustrating the carbohydrate binding affinity. The transcription of FmLC6 was
      detected only in hepatopancreas of normal shrimp. After injection with pathogens
      or immunostimulants, the expression of FmLC6 was significantly up-regulated and
      reached the highest level at 12 h post-injection except with lipoteichoic acid
      challenge. The FmLC6 expression was severely suppressed by knockdown based
      silencing. This gene silencing with co-injection by Vibrio parahaemolyticus
      caused increasing in cumulative mortality and reduction of the median lethal
      time. Purified recombinant proteins of an entire ORF and two individual CRDs of
      FmLC6 produced in Escherichia coli could induce a broad spectrum of microbial
      agglutination with calcium dependence. The agglutination induced by rFmLC6, rCRD1
      and rCRD2 was suppressed by galactose plus mannose, galactose and mannose,
      respectively which this event was confirmed by the inhibition of
      hemagglutination. All three recombinant proteins possessed ability to inhibit the
      bacterial growth with a dose-response. Purified rFmLC6 could bind directly to
      white spot syndrome virus particles and also its recombinant proteins including
      VP15, VP39A and VP28 with different affinity. Altogether, these results indicate
      that FmLC6 acts as a PRR to recognize invading microorganisms and leads to
      mediating the immune response to cooperation in pathogenic elimination via the
      binding, agglutination and antimicrobial activity.

PMID- 29842931
TI  - Safety of laparoscopic resection for colorectal cancer in patients with liver
      cirrhosis: A retrospective cohort study.
AB  - BACKGROUND: Patients with liver cirrhosis represent a high risk group for
      colorectal surgery. The safety and effectiveness of laparoscopy in colorectal
      surgery for cirrhotic patients is not clear. The aim of this study was to compare
      the outcomes of laparoscopic colorectal surgery with those of open procedure for
      colorectal cancer in patients with liver cirrhosis. MATERIALS AND METHODS: A
      total of 62 patients with cirrhosis who underwent radical resections for
      colorectal cancer from 2005 to 2014 were identified retrospectively from a
      prospective database according to the technique adopted (laparoscopic or open).
      Short- and long-term outcomes were compared between the two groups. RESULTS:
      Comparison of laparoscopic group and open group revealed no significant
      differences at baseline. In the laparoscopic group, the laparoscopic surgery was
      associated with reduced estimated blood loss (136 vs. 266 ml, p = 0.015), faster
      first flatus (3 vs. 4 days, p = 0.002) and shorter days to first oral intake (4
      vs. 5 days, p = 0.033), but similar operative times (p = 0.856), number of
      retrieved lymph nodes (p = 0.400) or postoperative hospital stays (p = 0.170).
      Despite the similar incidence of overall complications between the two groups
      (50.0% vs. 68.8%, p = 0.133), we observed lower morbidities in laparoscopic group
      in terms of the rate of Grade II complication (20.0% vs. 50.0%, p = 0.014). Long
      term of overall and Disease-free survival rates did not differ between the two
      groups. CONCLUSION: Laparoscopic colorectal surgery appears to be a safe and less
      invasive alternative to open surgery in some elective cirrhotic patients in terms
      of less blood loss or early recovery and does not result in additional harm in
      terms of the postoperative complications or long-term oncological outcomes.

PMID- 29842932
TI  - Increased yield of full GBA sequencing in Ashkenazi Jews with Parkinson's
      disease.
AB  - BACKGROUND: Variants in GBA are the most common genetic risk factor for
      Parkinson's disease (PD), and are especially prevalent in the Ashkenazi Jewish
      (AJ) population. However, most studies on GBA in AJ genotype only seven selected
      Gaucher-associated pathogenic variants rather than sequencing the whole gene,
      which may leave carriers of PD-associated GBA variants undiscovered. METHODS: GBA
      was fully sequenced using molecular inversion probes (MIPs) and Sanger sequencing
      in 735 AJ PD patients and 662 AJ controls, from Israel and New York. Additional
      AJ control data (n = 3044) from the Inflammatory Bowel Disease Exome Portal was
      used. RESULTS: Full GBA sequencing increased the number of variants discovered by
      17.4%, compared to targeted genotyping. An additional 17 PD patients were
      identified with GBA-associated PD. The p.E326K variant was found in 1.6% of AJ PD
      patients, making it the second most common PD-associated GBA variant in AJ. GBA
      variants were found in 18% of PD patients and 7.5% of controls (OR = 2.7, 95%CI =
      1.9-3.8, p < 0.0001). CONCLUSION: Without full sequencing of GBA, or at minimum
      including p.E326K in the genotyping panel, a significant proportion of variant
      carriers go undiscovered and may be incorrectly assigned as non-carriers in
      studies or clinical trials.

PMID- 29842933
TI  - A case of food-dependent exercise-induced angioedema.

PMID- 29842934
TI  - Enhancing the therapeutic effect via elimination of hepatocellular carcinoma stem
      cells using Bmi1 siRNA delivered by cationic cisplatin nanocapsules.
AB  - Resistance of hepatocellular carcinoma (HCC) to systemic chemotherapy is
      partially due to presence of drug-resistant cancer stem cells. Bmi1 protein is
      essential for survival and proliferation of HCC cancer stem cells (CSCs). Here,
      we report that Bmi1 siRNA (Bmi1siR) loaded in cationic nanocapsules of cisplatin
      (NPC) eliminated stem cells in situ HCC in mice. NPC/Bmi1siR was fabricated via
      electrostatic complexation of Bmi1 siRNA to NPCs, which had cores composed of
      cisplatin and were coated with cationic lipids. In vivo, NPC/Bmi1siR showed
      higher anti-tumor activity in HCC bearing mice compared with cisplatin or NPC.
      Critically, both flow cytometry (FACS) analysis in vitro and histological
      examination in vivo revealed that side population or CD133+ HCC cells were
      dramatically decreased by NPC/Bmi1siR treatment, suggesting that HCC CSCs were
      eliminated. Altogether, our results suggest that drug resistance of HCC can be
      overcome by co-delivering Bmi1 siRNA with cisplatin in cationic nanocapsules.

PMID- 29842935
TI  - Block of Kir channels by flonicamid disrupts salivary and renal excretion of
      insect pests.
AB  - Flonicamid is a selective insecticide for the control of sap-sucking insects; it
      exerts toxic effects by inhibiting insect feeding. However, its molecular target
      remains elusive. In this study, we functionally characterized NlKir1 channels of
      the brown planthopper (Nilaparvata lugens) in HEK293 cells. Homomeric NlKir1
      channels generated inward-rectifying K+ currents. Flonicamid inhibited NlKir1
      channels at nanomolar concentrations. Furthermore, flonicamid inhibited honeydew
      and salivary secretions of planthoppers, and reduced the renal excretion of
      female mosquitoes in a dose-dependent manner. The inhibitory effect of flonicamid
      on fluid secretion of isolated Malpighian tubules from Culex pipiens pullens was
      comparable to that of the selective Kir1 inhibitor. The observed physiological
      alterations by flonicamid are likely mediated by Kir1 channels and could lead to
      the disruption of feeding behaviors and eventually lethality. Our study
      establishes the Kir1 channel as the target of flonicamid and provided new
      insights into the mode of action of flonicamid.

PMID- 29842936
TI  - Plant Biotechnology: Green for Good IV.

PMID- 29842937
TI  - Is the independence of medical research at stake? On the forces shaping the
      research agenda.

PMID- 29842938
TI  - A Case of Psoas Muscle Endometriosis: A Distinct Approach to Diagnosis and
      Management.
AB  - Endometriosis is a common disease in women of childbearing age. Here, we report a
      case of psoas muscle endometriosis and our approach to treatment. A 28-year-old
      woman presented with an 8-month history of lower left abdominal and back pain.
      She was incorrectly diagnosed and treated for a psoas abscess at a previous
      hospital. Based on imaging results and previous history of severe dysmenorrhea, a
      diagnosis of psoas muscle endometriosis was considered. The patient underwent
      treatment with gonadotropin-releasing hormones and laparoscopic surgery and
      currently reports alleviation of symptoms. Psoas muscle endometriosis is rare,
      and the diagnosis can be difficult. It is important to recognize signs and
      symptoms to determine adequate treatment.

PMID- 29842939
TI  - Regarding "Evaluation of a Spray-type Novel Dextrin Hydrogel Adhesion Barrier
      under Laparoscopic Conditions in a Porcine Uterine Horn Adhesion Model".

PMID- 29842940
TI  - A quantitative metric for knee osteoarthritis: reference values of joint space
      loss.
AB  - OBJECTIVES: Knee osteoarthritis (OA) onset and progression has been defined with
      transitions in Kellgren-Lawrence (KL) grade or Osteoarthritis Research Society
      International (OARSI) Joint Space Narrowing (JSN) grade. We quantitatively
      describe one-year transitions in KL grade and JSN, using fixed joint space width
      (fJSW), among knees with or at risk of OA. METHODS: Radiographic assessments from
      the Osteoarthritis Initiative (OAI) were used to identify transitions in KLG and
      JSN grade between consecutive annual visits. The fJSW was measured in the medial
      and lateral compartments. The distribution of change in fJSW for KLG and JSN
      transitions were described, and mean change in fJSW was estimated using mixed
      models. RESULTS: KL grade and JSN scores were available for about 20,000 annual
      transitions from 6047 knees contributed by 3389 participants. Knees that remained
      stable in KL or OARSI-JSN over 1 year had mean medial fJSW loss between -0.06 and
      -0.19 mm/year. Transition from KL grade 0 to 1, 0 to 2, and KL 1 to 2 were
      similar with respect to mean medial fJSW loss (0.18-0.28 mm). Greatest annual
      changes in medial fJSW corresponded to KL 0 to 3 (1.62 mm), KL 2 to 4 (1.23 mm)
      and JSN 0 to 2 (1.85 mm). CONCLUSIONS: Anchoring quantitatively measured loss of
      joint space width to transitions in KL grade and JSN provides reference values
      based on traditional definitions of knee OA onset and progression.

PMID- 29842941
TI  - Signal intensity alteration within infrapatellar fat pad predicts knee
      replacement within 5 years: data from the Osteoarthritis Initiative.
AB  - OBJECTIVE: To investigate whether infrapatellar fat pad (IPFP) signal intensity
      (SI) alteration predicts the occurrence of knee replacement (KR) in knee
      osteoarthritis (OA) patients over 5 years. DESIGN: The subjects were selected
      from Osteoarthritis Initiative (OAI) study. Case knees (n = 127) were defined as
      those who received KR during 5 years follow-up visit. They were matched by
      gender, age and radiographic status with control knees (n = 127). We used T2
      weighted MR images to measure IPFP SI alteration using a newly developed
      algorithm in MATLAB. The measurements were assessed at baseline (BL), T0 (the
      visit just before KR) and 1 year before T0 (T-1). Conditional logistic regression
      was used to analyse the associations between IPFP SI alterations and the risk of
      KR. RESULTS: Participants were mostly female (57%), with an average age of 63.7
      years old and a mean body mass index (BMI) of 29.5 kg/m2. In multivariable
      analysis, the standard deviation (SD) of IPFP SI [sDev (IPFP)] and the ratio of
      high SI region volume to whole IPFP volume [Percentage (H)] measured at BL were
      significantly associated with increased risks of KR after adjustment for
      covariates. IPFP SI alterations measured at T-1 including sDev (IPFP), Percentage
      (H) and clustering effect of high SI [Clustering factor (H)] were significantly
      associated with higher risks of KR. All measurements were significantly
      associated with higher risks of KR at T0. CONCLUSIONS: IPFP SI is associated with
      the occurrence of KR suggesting it may play a role in end-stage knee OA.

PMID- 29842942
TI  - Cardiac resynchronisation therapy in paediatric patients with pacing induced
      cardiomyopathy - A single centre experience.

PMID- 29842943
TI  - AMPA receptor complex constituents: Control of receptor assembly, membrane
      trafficking and subcellular localization.
AB  - Fast excitatory transmission at synapses of the central nervous system is mainly
      mediated by AMPA receptors (AMPARs). Synaptic AMPAR number and function
      correlates with synaptic strength. AMPARs are thus key proteins of activity
      dependent plasticity in neuronal communication. Up- or down-regulation of
      synaptic AMPAR number is a tightly controlled dynamic process that involves
      export of receptors from the endoplasmic reticulum (ER) and Golgi apparatus,
      exocytosis and endocytosis as well as lateral diffusion of the receptors in the
      cell membrane. The four AMPAR subunits are embedded into a dynamic network of
      more than 30 interacting proteins. Many of these proteins are known to modulate
      receptor gating, trafficking and subcellular localization. Here, we will review
      the influence that AMPAR interacting proteins exert on trafficking and
      subcellular localization of the receptors by controlling their assembly, ER/Golgi
      apparatus export, and synaptic anchoring.

PMID- 29842944
TI  - Fungal mediated innate immune memory, what have we learned?
AB  - The binary classification of mammalian immune memory is now obsolete. Innate
      immune cells carry memory characteristics. The overall capacity of innate immune
      cells to remember and alter their responses is referred as innate immune memory
      and the induction of a non-specific memory resulting in an enhanced immune status
      is termed "trained immunity". Historically, trained immunity was first described
      as triggered by the human fungal pathogen Candida albicans. Since, numerous
      studies have accumulated and deciphered the main characteristics of trained
      immunity mediated by fungi and fungal components. This review aims at presenting
      the newly described aspect of memory in innate immunity with an emphasis on the
      historically fungal mediated one, covering the known molecular mechanisms
      associated with training. In addition, the review uncovers the numerous non
      specific effect that beta-glucans trigger in the context of infectious diseases
      and septicaemia, inflammatory diseases and cancer.

PMID- 29842945
TI  - Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro
      inflammatory phenotype.
AB  - Integrin alpha4/beta7 on circulating lymphocytes identifies them as gut-tropic,
      and can be targeted by the humanized antibody vedolizumab to treat inflammatory
      bowel disease (IBD). We found lymphocytes expressing alpha4/beta7 were
      significantly more responsive to the pro-inflammatory cytokines IL-6, IL-7, and
      IL-21, and less responsive to the regulatory T cell (Treg)-supporting cytokine IL
      2. Alpha4/beta7 was expressed by a smaller percent of FOXP3 + Helios+ thymically
      derived Tregs (tTregs) than FOXP3 + Helios- peripherally-derived Tregs (pTregs)
      or FOXP3- effector T cells. Integrin alpha4/beta7+ CD4 T cells were also rare
      among cells expressing the Th2 marker CRTh2, but enriched in cells bearing the
      circulating T follicular helper cell marker CXCR5. Thus the effect of this anti
      integrin therapy on the mucosal immune system may be more qualitative than
      quantitative, and selectively replace pro-inflammatory effector cells with Tregs
      and Th2 cells to facilitate immune tolerance in the mucosa without globally
      depleting lymphocytes from the intestinal mucosa.

PMID- 29842946
TI  - Combination of anti-citrullinated protein antibodies and rheumatoid factor is
      associated with increased systemic inflammatory mediators and more rapid
      progression from preclinical to clinical rheumatoid arthritis.
AB  - The development of rheumatoid factor (RF) and/or anti-citrullinated protein
      antibodies (ACPAs) can be observed years prior to clinical diagnosis of
      rheumatoid arthritis (RA). Nevertheless, the interaction between these two
      autoantibodies and their combined effect on development of RA is unclear. We
      measured RF, cytokines, and ACPA subtypes in serial pre-clinical serum samples
      collected from 83 US veterans who all developed RA. Levels of cytokines and ACPAs
      were compared between the following groups: anti-cyclic citrullinated peptide
      (anti-CCP)-/RF- (double negative), anti-CCP+/RF-, anti-CCP-/RF+, or anti-CCP+/RF+
      (double-positive). The double-positive subgroup had significantly higher levels
      of 20 inflammatory cytokines and 29 ACPA reactivities, and the shortest interval,
      1.3 years, between the preclinical sample timepoint and diagnosis of RA. Thus,
      the combined presence of ACPAs and RF is associated with a more rapid progression
      to RA, suggesting that anti-CCP+/RF+ individuals have a more advanced preclinical
      disease state and that the onset of RA may be imminent.

PMID- 29842947
TI  - Use of Partial Least Squares improves the efficacy of removing unwanted
      variability in differential expression analyses based on RNA-Seq data.
AB  - RNA-Seq technology has revolutionized the face of gene expression profiling by
      generating read count data measuring the transcript abundances for each queried
      gene on multiple experimental subjects. But on the downside, the underlying
      technical artefacts and hidden biological profiles of the samples generate a wide
      variety of latent effects that may potentially distort the actual transcript/gene
      expression signals. Standard normalization techniques fail to correct for these
      hidden variables and lead to flawed downstream analyses. In this work I
      demonstrate the use of Partial Least Squares (built as an R package 'SVAPLSseq')
      to correct for the traces of extraneous variability in RNA-Seq data. A novel and
      thorough comparative analysis of the PLS based method is presented along with
      some of the other popularly used approaches for latent variable correction in RNA
      Seq. Overall, the method is found to achieve a substantially improved estimation
      of the hidden effect signatures in the RNA-Seq transcriptome expression landscape
      compared to other available techniques.

PMID- 29842948
TI  - GB2sequin - A file converter preparing custom GenBank files for database
      submission.
AB  - The typical wet lab user often annotates smaller sequences in the GenBank format,
      but resulting files are not accepted for database submission by NCBI. This makes
      submission of such annotations a cumbersome task. Here we present "GB2sequin" an
      easy-to-use web application that converts custom annotations in the GenBank
      format into the NCBI direct submission format Sequin. Additionally, the program
      generates a "five-column, tab-delimited feature table" and a FASTA file. Those
      are required for submission through BankIt or the update of an existing GenBank
      entry. We specifically developed "GB2sequin" for the regular wet lab researcher
      with strong focus on user-friendliness and flexibility. The application is
      equipped with an intuitive graphical interface and a comprehensive documentation.
      It can be employed to prepare any GenBank file for database submission and is
      freely available online at https://chlorobox.mpimp
      golm.mpg.de/GenBank2Sequin.html.

PMID- 29842949
TI  - Evaluation of computational techniques for predicting non-synonymous single
      nucleotide variants pathogenicity.
AB  - The human genetic diseases associated with many factors, one of these factors is
      the non-synonymous Single Nucleotide Variants (nsSNVs) cause single amino acid
      change with another resulting in protein function change leading to disease. Many
      computational techniques have been released to expect the impacts of amino acid
      alteration on protein function and classify mutations as pathogenic or neutral.
      Here in this article, we assessed the performance of eight techniques; FATHMM,
      SIFT, Provean, iFish, Mutation Assessor, PANTHER, SNAP2, and PON- P2 using a
      VaribenchSelectedPure dataset of 2144 pathogenic variants and 3777 neutral
      variants extracted from the free standard database "Varibench." The first five
      techniques achieve (45.60-83.75) % specificity, (52.64-94.13) % sensitivity,
      (51.00-88.90) % AUC, and (49.76-88.24) % ACC on whole dataset, while all eight
      techniques achieve (36.54-77.88) % specificity, (50.00-75.00) % sensitivity,
      (51.00-76.40) % AUC, and (25.00-77.78) % ACC on random sample dataset. We also
      created a Meta classifier (CSTJ48) that combines FATHMM, iFish, and Mutation
      Assessor. It registers 96.33% specificity, 86.07% sensitivity, 91.20% AUC, and
      91.89 ACC. By comparing the results, it's clear that FATHMM gives the highest
      performance over the seven individual techniques, where it achieves 83.75% and
      77.88% specificity, 94.13%, and 75.00% sensitivity, 88.90% and 76.40% AUC, and
      88.24% and 77.78% ACC on whole and random sample dataset, respectively. Also, the
      launched Meta classifier (CSTJ48) is outperforming over all the eight individual
      tools that compared here.

PMID- 29842950
TI  - pLoc_bal-mGpos: Predict subcellular localization of Gram-positive bacterial
      proteins by quasi-balancing training dataset and PseAAC.
AB  - Knowledge of protein subcellular localization is vitally important for both basic
      research and drug development. With the avalanche of protein sequences emerging
      in the post-genomic age, it is highly desired to develop computational tools for
      timely and effectively identifying their subcellular localization purely based on
      the sequence information alone. Recently, a predictor called "pLoc-mGpos" was
      developed for identifying the subcellular localization of Gram-positive bacterial
      proteins. Its performance is overwhelmingly better than that of the other
      predictors for the same purpose, particularly in dealing with multi-label systems
      in which some proteins, called "multiplex proteins", may simultaneously occur in
      two or more subcellular locations. Although it is indeed a very powerful
      predictor, more efforts are definitely needed to further improve it. This is
      because pLoc-mGpos was trained by an extremely skewed dataset in which some
      subset (subcellular location) was over 11 times the size of the other subsets.
      Accordingly, it cannot avoid the bias consequence caused by such an uneven
      training dataset. To alleviate such bias consequence, we have developed a new and
      bias-reducing predictor called pLoc_bal-mGpos by quasi-balancing the training
      dataset. Rigorous target jackknife tests on exactly the same experiment-confirmed
      dataset have indicated that the proposed new predictor is remarkably superior to
      pLoc-mGpos, the existing state-of-the-art predictor in identifying the
      subcellular localization of Gram-positive bacterial proteins. To maximize the
      convenience for most experimental scientists, a user-friendly web-server for the
      new predictor has been established at http://www.jci-bioinfo.cn/pLoc_bal-mGpos/,
      by which users can easily get their desired results without the need to go
      through the detailed mathematics.

PMID- 29842951
TI  - Effect of solution plasma process with hydrogen peroxide on the degradation and
      antioxidant activity of polysaccharide from Auricularia auricula.
AB  - Solution plasma process (SPP) in combination with hydrogen peroxide (H2O2) were
      adopted to the degradation of Auricularia auricula polysaccharide (AAP). The
      results showed that SPP irradiation with H2O2 was effective for the AAP
      degradation. The intrinsic viscosity ([eta]) of AAP solution decreased
      exponentially with increase in irradiation time. The degradation reaction closely
      fitted to the first order kinetics. The degradation rate constant after SPP
      irradiation with H2O2 was approximately 4.2 times that with SPP irradiation
      alone. GPC analysis showed that the molecular weight distribution of AAP was
      narrowed during degradation. FTIR and 13C NMR analysis revealed that primary
      structure of APP was not changed by the combination method. In vitro antioxidant
      activity of the polysaccharides was evaluated by determining their reducing power
      and radical (ABTS radical and superoxide radical) scavenging abilities. It was
      found that the degraded AAP possessed the higher antioxidant activity. The
      results suggested that SPP with H2O2 was an effective means for AAP degradation.

PMID- 29842952
TI  - Structural characterization and alpha-glucosidase inhibitory activity of
      polysaccharides extracted from Chinese traditional medicine Huidouba.
AB  - In this research, the crude polysaccharides were extracted from Chinese
      traditional medicine Huidouba and then isolated and purified by DEAE-52 cellulose
      and Sephadex G-100 chromatographic columns. The hypoglycemic activities of two
      fractions were determined by alpha-glucosidase inhibitory activity in vitro. The
      fraction HDBP-3A showed the best alpha-glucosidase inhibitory activity with an
      IC50 of 0.0075 mg/mL, which was lower than the acarbose positive control (IC50 of
      0.092 mg/mL). The structural features of HDBP-3A was investigated by the high
      performance gel permeation chromatography (HPGPC), gas chromatography(GC), UV
      spectroscopy, FT-IR, periodate oxidation and Smith degradation. The results
      demonstrated that the HDBP-3A with a molecular weight of 86,749 Da mainly
      composed of l-rhamnose, d-fucose, l-arabinose, d-xylose, d-mannose, d-glucose and
      d-galactose with the molar ratio of 2.33:1.58:1.00:1.37:4.86:4.00:7.30. The
      branches of HDBP-3A were composed of (1 -> 4)-linked, (1 -> 6)-linked, (1 -> 2)
      linked or (1 -> 3)-linked. The IR spectrum implied that beta-pyranoside linkage
      and alpha-configurations existed in HDBP-3A simultaneously.

PMID- 29842953
TI  - Engineering and characterization of a novel low temperature active and thermo
      stable esterase from marine Enterobacter cloacae.
AB  - Esterases are one of the most important industrial enzymes. Here, a novel estA
      was cloned from Enterobacter sp. and characterized. The sequence alignment
      results showed that it was a novel esterase. The purified EstA had a molecular
      weight of 26 KDa with an optimum temperature and pH of 40  degrees C and 9.0.
      EstA retained >70% activity between 0  degrees C and 20  degrees C, indicating it
      was a low temperature active enzyme. EstA exhibited low activity after incubation
      at 45  degrees C for 120 min or 50  degrees C for 30 min. In the presence of
      organic solvents, detergents and different concentrations of NaCl, EstA retained
      high activity. In order to improve thermal stability, a mutant A92D with better
      thermal stability than EstA was obtained by random mutation. ESTA92D showed high
      activity at 45  degrees C for 120 min and maintained 85% of the original activity
      at 50  degrees C for 30 min, approximately a 3.4-fold increase over EstA.
      Homology modeling analysis showed that the improved thermostability of ESTA92D
      was attributed to hydrophilic Asp rather than hydrophobic Ala, leading to an
      increase of the interaction and solubility as well as the surrounding area. The
      improved thermostability of low-temperature-active EstA suggests its immense
      applications in industrial applications.

PMID- 29842954
TI  - Characterization of a novel thermostable GH7 endoglucanase from Chaetomium
      thermophilum capable of xylan hydrolysis.
AB  - A new endoglucanase encoding gene (ctendo7) was cloned from the thermophilic
      fungus Chaetomium thermophilum and heterologously expressed in Pichia pastoris.
      The recombinant CTendo7 enzyme was purified by Ni2+ affinity chromatography and
      subsequently characterized. CTendo7 belongs to glycoside hydrolase family 7, and
      exhibited considerable activity against sodium carboxymethyl cellulose (CMC-Na)
      and xylan of 1.91 IU/mg and 3.05 IU/mg at the optimum reaction condition of 55 
      degrees C, pH 5.0, respectively. The purified enzyme displayed relatively good
      thermostability. The residual endoglucanase and xylanase activities were 74.3%
      and 66.2% after a 60 min pre-incubation at 70  degrees C. Additionally, Ag+, Fe3+
      and Cu2+ negatively affected the enzyme's activity, while the presence of 1 mM
      and 5 mM Mn2+ significantly enhanced both endoglucanase and xylanase activities.
      Generation of soluble oligosaccharides from lignocellulose is a critical step in
      bioethanol production, and it is noteworthy that CTendo7 produced cello
      oligosaccharides and xylo-oligosaccharides from the continuous enzymatic
      saccharification of CMC-Na and xylan, respectively. This is the first detailed
      report on a novel bifunctional endoglucanase/xylanase enzyme from C.
      thermophilum. Furthermore, the excellent properties of CTendo7 distinguish it as
      a promising candidate for industrial lignocellulosic biomass conversion.

PMID- 29842955
TI  - Interfacial and emulsion stabilized behavior of lysozyme/xanthan gum
      nanoparticles.
AB  - Interfacial adsorption kinetics and stabilizing emulsion behavior of
      lysozyme/xanthan gum nanoparticles (Ly/XG NPs) by variation of particle size and
      energy input. The interfacial rheology indicated that interfacial adsorption
      behavior of Ly/XG NPs displayed in a particle size manner. Increasing the
      particle size of Ly/XG NPs hindered its initial diffusion onto the interface.
      Smaller size was helpful for its fast diffusion to the interface. KP (rate
      constant of penetration) and KR (rate constant of penetration) of Ly/XG NPs were
      both affected by particle size. The KP for adsorbed Ly/XG NPs increased as the
      particle sizes increased. KR was considerably higher than KP, indicating the
      structural rearrangement of adsorbed Ly/XG NPs played an important part in
      interfacial film formation. The morphology of Pickering emulsion indicated its
      drop sizes were determined by the oil/aqueous volume fraction and prepared style.
      The higher energy input the size become smaller. Based on interfacial adsorption
      kinetics and microstructure of Pickering emulsions, the stabilization behavior
      was related to particle-particle associations and conformational changes of Ly/XG
      NPs. This work confirmed Ly/XG NPs could form Pickering emulsion by selecting
      different particle size and emulsification process, and offer promising prospects
      in stabilizing emulsion with the demands of surfactant-free.

PMID- 29842956
TI  - Preparation of a bio-composite of sericin-g-PMMA via HRP-mediated graft
      copolymerization.
AB  - Silk sericin (SS) derived from silkworms has the characteristics of anti
      oxidation, antibacterial, and biocompatibility, however, high solubility in water
      restricted its applications in biomedical fields. In the present work, SS was
      enzymatically graft-copolymerized with a hydrophobic vinyl monomer of methyl
      methacrylate (MMA), through a free radical reaction, through the combination use
      of hydrogen peroxide and horseradish peroxidase (HRP). Efficacy of the HRP
      mediated reaction was examined by means of FTIR, SDS-PAGE, and SEC chromatogram.
      A bio-composite of SS-graft-polymethyl methacrylate (SS-g-PMMA) was constructed
      subsequently, the corresponding wettability, thermal behavior, and
      biocompatibility of the obtained composite were examined, respectively. The data
      reveal that MMA was successfully copolymerized with the reactive sites in sericin
      chains, resulting in a noticeable increase in the molecular weight. For the
      membrane of SS-g-PMMA, the surface hydrophobicity was evidently improved compared
      to that of the untreated, according to the determined data of water contact angle
      and dissolution ratio. The current work develops an eco-friendly technique for
      reuse of the industrial waste like sericin, and provides a novel method for
      preparation of the sericin-based biomaterials as well.

PMID- 29842957
TI  - Effects of functional beta-glucan on proliferation, differentiation, metabolism
      and its anti-fibrosis properties in muscle cells.
AB  - Skeletal muscles plays a crucial role in metabolism and exercise. Fuctional beta
      glucan is polysaccharide that is found in the cell walls of cereal, which is
      known to reduce cholesterol and lipid, prevent diabetes, cancer and
      cardiovascular diseases. In an attempt to identify beta-glucan that could promote
      skeletal muscle function, we analyzed the proliferation, differentiation,
      metabolism and anti-fibrotic properties of beta-glucan in C2C12 muscle cells.
      Treatment of beta-glucan in C2C12 myoblasts led to increased proliferation and
      differentiation. Besides that, we found that C2C12 myotubes treated with beta
      glucan displayed a fast-to-slow muscle fiber conversion and improved oxidative
      metabolism. Further study revealed that beta-glucan treatment could prevent
      myotubes from becoming myofibroblasts. Together, our study suggests that
      functional beta-glucan might have a therapeutic potential to improve skeletal
      muscle function, which might contribute to the development of beta-glucan.

PMID- 29842958
TI  - Structural, morphological, optical and biological properties of pure ZnO and
      agar/zinc oxide nanocomposites.
AB  - In this work, ZnO nanoparticles were prepared by in situ chemical precipitation
      method in the presence of Agar biopolymer. The influence of Agar concentrations
      on the structural, morphological and optical properties of ZnO have been
      investigated. The XRD pattern of Pure ZnO and Agar/ZnO nanocomposites indicates
      the hexagonal wurtzite phase of ZnO. The crystallite size of pure ZnO and
      Agar/ZnO nanocomposites was found to be in the range of 35.5 to 19.73 nm. Pure
      ZnO and Agar/ZnO nanocomposites showed nanospheroid and nanopaddy shaped
      morphology from FESEM studies. The interplanar distance observed from the HRTEM
      image confirms the plane of the prepared material. The elemental composition of
      the samples were characterized by EDX. The optical properties of Pure ZnO and
      Agar/ZnO nanocomposites were characterized by UV, FTIR and PL. The band gap of
      Agar/ZnO nanocomposites were varied with the Agar concentration. Oxygen vacancy
      induced photoluminescence of ZnO are observed and its intensity is found to be
      increased linearly with the Agar concentration. The antibacterial activity of ZnO
      and Agar/ZnO nanocomposites was evaluated by disc diffusion method against Gram
      positive (B.subtilis) and Gram-negative (P. aeruginosa) bacteria. The
      cytotoxicity of Agar/ZnO nanocomposites was studied against Normal (L929) and
      Breast cancer cell line (MB231). The result of this investigation reveals that
      the Agar/ZnO nanocomposites deliver a dose dependent toxicity in normal and
      cancer cell line.

PMID- 29842959
TI  - Effects of JAK2 V556F mutation on the JAK2's activity, structural stability and
      the transformation of Ba/F3 cells.
AB  - Although roles of somatic JAK2 mutations in clonally myeloproliferative neoplasms
      (MPNs) are well established, roles of germline JAK2 mutations in the pathogenesis
      of MPNs remain unclear. Recently, a novel activating, germline JAK2 F556V
      mutation was identified and involved in the pathogenesis of MPNs, but, its
      pathogenesis mechanism was still unknown. In this study, homology models of JAK2
      demonstrated that F556 located between two threonine residues which interacted
      with ATP phosphate groups by hydrogen bonds, Thr555 with the gamma-phosphate and
      Thr557 with the beta-phosphate in the active site of JAK2's JH2 domain. Moreover,
      the hydrogen bond between Thr557 and Arg715 played vital roles in sustaining the
      structural conformation of JH2's active site and JH1-JH2 domains' interactions.
      When F556 was replaced by other amino acids except Trp, the hydrogen bond, JH2
      domain's structural conformation and JH1-JH2 domains' interactions disrupted for
      changing the helix between beta2 and beta3 strands which finally caused JAK2
      activation. Mechanistic and functional studies showed that JAK2 F556V mutation
      disrupted JAK2 JH2 domain's activity, caused JAK2-STAT5 pathway activation and
      promoted the proliferation of BaF3 cells. Thus, our results herein may provide
      clues to understand the pathogenesis mechanism of JAK2 F556V mutation in the
      MPNs.

PMID- 29842960
TI  - Conformational change of lysozyme on the interaction with gene carrier
      polyethyleneimine.
AB  - Polyethyleneimine (PEI) has been considered as "golden standard" for polymeric
      gene delivery carriers, however also induces cytotoxicity. To reveal the
      molecular basis of PEI cytotoxicity, absorption, resonance Rayleigh scattering,
      fluorescence, circular dichroism and isothermal titration calorimetry were
      conducted to investigate the interaction between PEI (average molecular weight
      25,000 Da) and lysozyme and its influence on the conformation of the enzyme. PEI
      is an amphiphilic polymer with strong hydrogen bonding capability and weak
      hydrophobicity due to dense amine groups and methyl groups. However, the
      hydropathic characteristics that hydrophobic methyl groups and hydrophilic amine
      groups distributed alternatively along the polymer chain made it difficult to
      penetrate into the hydrophobic core, but subject to binding onto the surface of
      lysozyme via hydrophobic interaction and hydrogen bond, leading to a more compact
      conformation and an increased surface hydrophobicity of the enzyme.

PMID- 29842961
TI  - The enhancing effect of Aubang Gahl Soo on the hippocampal synaptic plasticity
      and memory through enhancing cholinergic system in mice.
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Aubang Gahl Soo (AGS) is a Korean traditional
      drink manufactured from medicinal plants and fruits using sugar or honey.
      Although traditional old book stated its effects on body, there is no scientific
      evidence yet. Therefore, in the present study, we tested AGS on brain functions.
      AIM OF THIS STUDY: In this study, we tried to uncover the effect of on brain
      functions. To do this we examined the action of AGS on the hippocampal synaptic
      function and memory in mice. MATERIALS AND METHODS: To examine the effect of AGS
      on synaptic plasticity, we observed input-output curves (I/O curve), paired-pulse
      facilitation (PPF), and long-term potentiation (LTP) using mouse hippocampal
      slices. Moreover, to investigate the functional relevance of the effect of AGS on
      synaptic plasticity, we conducted passive avoidance, Y-maze and Morris water maze
      tests. To examine relevant mechanism, acetylcholinesterase (AChE) activity and
      acetylcholine (ACh) level assay were also conducted. RESULTS: In the basal
      synaptic transmission study, we found that AGS did not affect I/O curves and PPF.
      However, AGS facilitated hippocampal LTP in a concentration-dependent manner.
      Moreover, AGS blocked AChE activity (IC50 = 485 MUg/ml). Moreover, ACh level was
      increased by AGS (100 MUg/ml) treatment. Along with this, facilitating effect of
      AGS on hippocampal LTP also blocked by scopolamine, a muscarinic acetylcholine
      receptor antagonist. Moreover, AGS also ameliorated memory impairments induced by
      scopolamine in passive avoidance, Y-maze, and Morris water maze tests.
      CONCLUSIONS: These results suggest that AGS facilitates hippocampal LTP through
      activating cholinergic system and ameliorates cholinergic dysfunction-induced
      memory deficit.

PMID- 29842962
TI  - Bioactive compounds and health benefits of some palm species traditionally used
      in Africa and the Americas - A review.
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: According to previous ethno-medicinal reviews,
      Cocos nucifera, Elaeis guineensis and Phoenix dactylifera are among the main
      palms which are often used on the American and African continents to treat
      infections, infestations and disorders in the digestive, respiratory, genito
      urinary, dermal, endocrine, cardiovascular, muscular-skeletal, mental and neural
      systems, as well as neoplasms, dental issues and metabolic and nutritional
      disorders. In addition, one or more species of the wild genera Acrocomia, Areca,
      Astrocaryum, Attalea, Bactris, Borassus, Calamus, Chamaedorea, Chamaerops,
      Euterpe, Hyphaene, Mauritia, Oenocarpus and Syagrus have a high number of records
      of these ethno-medicinal uses. The most used parts of the palm tree are the
      fruits, followed by roots, seeds, leaves and flower sap. AIM OF THE STUDY: This
      review discusses the phytochemical composition and the pharmacological properties
      of these important ethno-medicinal palms, aiming to provide a contribution to
      future research prospects. MATERIALS AND METHODS: Significant information was
      compiled from an electronic search in widely used international scientific
      databases (Google Scholar, Science Direct, SciFinder, Web of Science, PubMed,
      Wiley on line Library, Scielo, ACS Publications), and additional information was
      obtained from dissertations, theses, books and other relevant websites. RESULTS:
      Palms, in general, are rich in oils, terpenoids and phenolic compounds. Fruits of
      many species are notable for their high content of healthy oils and fat-soluble
      bioactive compounds, mainly terpenoids, such as pigment carotenoids (and
      provitamin A), phytosterols, triterpene pentacyclics and tocols (and vitamin E),
      while other species stood out for their phenolic compounds derived from benzoic
      and cinnamic acids, along with flavan-3-ol, flavone, flavonol, and stilbene
      compounds or anthocyanin pigments. In addition to fruits, other parts of the
      plant such as seeds, leaves, palm heart, flowers and roots are also sources of
      many bioactive compounds. These compounds are linked to the ethno-medicinal use
      of many palms that improve human health against infections, infestations and
      disorders of human systems. CONCLUSIONS: Palms have provided bioactive samples
      that validate their effectiveness in traditional medicine. However, the intensive
      study of all palm species related to ethno-medicinal use is needed, along with
      selection of the most appropriate palm accessions, ripe stage of the fruit and
      /or part of the plant. Furthermore, the complete profiles of all phytochemicals,
      their effects on animal models and human subjects, and toxicological and clinical
      trials are suggested, which, added to the incorporation of improved technological
      processes, should represent a significant advance for the implementation of new
      opportunities with wide benefits for human health.

PMID- 29842963
TI  - The use of medicinal plants by pregnant women in Africa: A systematic review.
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal plant (MP) use during pregnancy is
      common in Africa and may have profound effects on both the mother and the
      developing foetus. A lack of overview complicates monitoring and regulating the
      use of MPs during pregnancy. AIM OF THE STUDY: This systematic review analyses
      prevalence of use of MPs during pregnancy, regional distribution, types and
      prevalence, MP properties, potential health risks, and consensus of MPs use, and
      suggests relevant measures to mitigate negative effects on pregnancy. MATERIALS
      AND METHODS: A search was undertaken using a range of scientific databases
      (Medline, Embase, African Journals OnLine, Google Scholar and Biological
      Abstracts), non-governmental organisations, various African universities and
      regulatory websites for original published and unpublished studies that assess
      and indicate the prevalence of use of MPs during pregnancy in Africa. Additional
      articles were located by exploring pertinent bibliographies, and contacting
      experts. RESULTS: A total of 3659 MP-use studies were found, but only 303
      articles received full-text assessment for eligibility and finally only 50
      scientific papers were eligible for the systematic review. The prevalence of MP
      use by pregnant women varied widely from 2% to 100%. Twenty-eight studies (56%)
      specified one or more plant species used as MP during pregnancy. The major
      reasons for MP use were relief of nausea and vomiting during pregnancy (NVP),
      stimulation of labour, and facilitation of childbirth. The most commonly cited MP
      species were Zingiber officinale Roscoe, Allium sativum L. and Cucurbita pepo L.
      and these were used for relief of NVP, motion sickness and as a nutritional
      supplement. Route of administration was most commonly oral, and few adverse
      effects were reported. CONCLUSIONS: The use of MPs among pregnant women in Africa
      is prevalent, and the most commonly used plant species are not known to have
      harmful foetal effects during pregnancy. However, many of the MP species are
      poorly studied and teratogenic effects cannot be ruled out. Collaboration between
      healthcare providers and traditional practitioners to inform about the safe use
      of MPs may promote safer pregnancies and better health for mothers and infants.

PMID- 29842964
TI  - Diuretic herb Gomphrena celosioides Mart. (Amaranthaceae) promotes sustained
      arterial pressure reduction and protection from cardiac remodeling on rats with
      renovascular hypertension.
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Gomphrena celosioides Mart., belonging to the
      Amaranthaceae family, is a weed known as "perpetua," and its ethnopharmacological
      use is to treat of urinary tract disorders and kidney stones. Urinary tract
      disorders and kidney stones could include several pathological conditions such
      hypertension, diuretic and lithiasic problems. In the present work a model of
      renovascular hypertension was developed in vivo to investigate its usefulness as
      an antihypertensive drug. AIM OF THE STUDY: Evaluate the effect of acute and 28
      day oral administration of G. celosioides extract on systemic arterial pressure
      and diuresis of renovascular-hypertensive rats, as well as its effect on cardiac
      remodeling and vascular reactivity. MATERIALS AND METHODS: Ethanolic extract of
      G. celosioides (EEGC) was used. To induce renovascular hypertension, adult male
      Wistar rats were submitted to Goldblatt 1K1C or 2K1C surgery. The mean arterial
      pressure (MAP) of 1K1C animals was directly assessed by cannulation of the
      carotid artery before and after intraduodenal acute administration of 30, 100 or
      300 mg/kg of EEGC. For the 4-week assay, 2K1C animals received daily treatments
      with water (control group), 100 mg/kg EEGC or 15 mg/kg enalapril for 28 days.
      Diuresis and caudal blood pressure were assessed weekly, and at the 28th day of
      treatment, the MAP was directly quantified shortly before euthanasia. Internal
      organs were removed, weighed and routinely processed for histology and the left
      ventricle wall was measured. Blood was collected for biochemical analysis and
      mechanism investigation by quantification of angiotensin converting enzyme (ACE)
      activity and aldosterone, nitrite and thiobarbituric acid reactive substances
      (TBARS) concentration. The rats' mesenteric beds were isolated and cannulated to
      have their pressure variation assessed after crescent doses of phenylephrine
      (Phe), acetylcholine (ACh) and sodium nitroprusside (SNP). RESULTS: EEGC acutely
      reduced MAP the dose of 100 mg/kg. In the 4-week assay, EEGC acted as diuretic
      after acute administration after 1, 2, 3 and 4 weeks of treatment. EEGC also
      acted as an antihypertensive and it showed significant difference already after 1
      week (and after 3 and 4 weeks) compared to control, with its MAP close to pre
      surgery values at the end of the experiment. It promoted ACE inhibition, which
      led to lower aldosterone levels. The lower TBARS and higher nitrite concentration
      found in the EEGC group suggest antioxidant activity and NO maintenance.
      Moreover, EEGC counteracted the impairment of vascular reactivity induced by
      renovascular hypertension. The extract group presented thinner left ventricle
      wall compared to the control, meaning reduced hypertension-induced cardiac
      remodeling. CONCLUSIONS: The G. celosioides diuretic effect is maintained on
      renovascular hypertensive rats and can reduce the blood pressure after the first
      week of treatment by inhibiting ACE and these effects are longstanding and strong
      enough to promote protection against cardiac remodeling. Therefore, it shows
      potential as an antihypertensive drug.

PMID- 29842965
TI  - Trichosanthis Fructus: botany, traditional uses, phytochemistry and pharmacology.
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Trichosanthis Fructus (ripe fruits of
      Trichosanthes kirilowii Maxim. and Trichosanthes rosthornii Harms) is an
      essential traditional Chinese medicine to treat thoracic obstruction, angina,
      cardiac failure, myocardial infarction, pulmonary heart disease, some cerebral
      ischaemic diseases, etc. The present report reviews the advancements in research
      on the botany, traditional uses, phytochemistry and pharmacology of Trichosanthis
      Fructus. Finally, perspectives on future research and its possible directions are
      discussed. AIM OF THE STUDY: This review provides up-to-date information about
      the botany, traditional uses, phytochemistry, pharmacology, toxicity and quality
      control of Trichosanthis Fructus and discusses the perspectives on future
      research and possible directions of this traditional Chinese Medicine and its
      origin plants. MATERIALS AND METHODS: The information on Trichosanthes kirilowii
      Maxim. and Trichosanthes rosthornii Harms was collected from published scientific
      materials, including books; monographs on medicinal plants; pharmacopoeia and
      electronic databases such as SCI finder, PubMed, Web of Science, ACS, Science
      Direct, Wiley, Springer, Taylor, CNKI and Google Scholar. RESULTS: Approximately
      162 compounds, including terpenoids, phytosterols, flavonoids, nitrogenous
      compounds and lignans, have been isolated and identified from Trichosanthes
      kirilowii Maxim. and Trichosanthes rosthornii Harms. Numerous studies have shown
      that the extracts and compounds isolated from these two plants exhibit
      pharmacological activities, including protection against myocardial ischaemia,
      calcium antagonist, endothelial cell protection, anti-hypoxic, anti-platelet
      aggregation, expectorant, anti-inflammatory, cytotoxic and antioxidant.
      CONCLUSIONS: Trichosanthis Fructus is an essential traditional Chinese medicine
      with pharmacological activities that mainly affect the cardiovascular system.
      This review summarises its botany, traditional uses, phytochemistry and
      pharmacology. Future research is needed to clarify the different uses of the
      seeds, pericarps and fruits. Quality control of investigations of the fruits
      should be improved, and the potential uses of the flesh, leaves and twigs should
      be further explored.

PMID- 29842966
TI  - Development of the Trying New Foods Scale: A preschooler self-assessment of
      willingness to try new foods.
AB  - Food neophobia, or reluctance to try new foods, emerges typically in early
      childhood and can impact child food acceptance and dietary quality. Measures of
      child neophobia have largely been developed from an adult point of view and the
      items focusing on fear and disgust were created from observations of children's
      behaviors or from adult assumptions regarding the source of children's reluctance
      to try new foods. Using group interviews with 3-5-y-old children (n = 229) we
      investigated what the experience of being asked trying new foods is like for
      preschoolers. From their answers, we crafted a new assessment, The Trying New
      Foods Scale, designed to ask children about their self-competence to try new
      foods. Next, we measured preschoolers' responses (n = 233; 3-5 years of age; 107
      boys, 126 girls) to these items and observed their willingness to taste 7 novel
      foods and their affective ratings of the foods as measures of criterion validity.
      A principal components analysis (PCA) revealed a single 9-item component for the
      Trying New Foods Scale (mean +/- s.d. = 3.08 +/- 0.70; alpha = 0.88). Children's
      Trying New Foods Scale score positively correlated with their willingness to try
      foods ratio (r = 0.21, p = .001). Initial findings indicate that the Trying New
      Foods Scale for preschoolers has good psychometric characteristics, including
      preliminary evidence of criterion validity. Children who perceived themselves as
      more willing to try foods actually performed the behavior of trying more foods
      and rated the foods more favorably than children who reported lower self
      competence to try foods. Understanding neophobia from the perspective of the
      young child, and their perceptions of self-competence related to trying new
      foods, may facilitate our ability to evaluate young children's food acceptance
      patterns.

PMID- 29842967
TI  - Parental feeding practices associated with children's eating and weight: What are
      parents of toddlers and preschool children doing?
AB  - Parental feeding practices are associated with children's eating behaviours and
      weight, yet current use of such practices lacks detailed description. This limits
      our understanding of which behaviours to target to promote healthy growth. We
      explored the frequency with which a range of parental feeding practices occurs in
      mothers of toddler and preschool children. Combined data from four Australasian
      trials of healthy feeding and growth were utilized, each using the Comprehensive
      Feeding Practices Questionnaire (CFPQ). Data were included from mothers of
      toddlers (1.3-2 years; n = 1344) and preschool children (4-6 years; n = 795).
      Means and standard deviations for each CFPQ dimension were calculated for the two
      age groups. Scores were categorised by frequency, and percentages in each
      category calculated. Linear regression analysis determined associations between
      socio-demographics and feeding practices. In both age groups, mothers reported
      extensive use of some CFPQ dimensions including modelling, encouraging balance
      and variety, and healthy food environment (between 84% and 100% reported using
      these practices 'usually' to 'often'). Greater variation existed for other
      practices including pressure to eat and restriction for health. Food as a reward
      and pressure to eat were used more with preschool children (M = 2.5, SD = 1.0 and
      M = 3.1 SD = 0.9) than with toddlers (M = 1.7, SD = 0.8 and M = 2.5 SD = 0.9).
      For both age groups, mothers' age, education, SEP and BMI category, or the
      child's BMI, sex, or age predicted use of some feeding practices. Feeding
      practices such as modelling and providing a healthy food environment are
      important, but interventions are unlikely to detect effects as most parents
      report following best practice. In contrast, given greater variability in
      reported use of other feeding practices like pressure to eat and restriction for
      health these constructs may be more likely to detect change.

PMID- 29842968
TI  - In adolescence a higher 'eveningness in energy intake' is associated with higher
      total daily energy intake.
AB  - The present manuscript addressed two hypotheses: (i) As children age, energy
      intake is shifted from morning (energy intake <11am) to evening hours (energy
      intake >6pm) (ii) A higher 'eveningness in energy intake' (i.e. evening minus
      morning energy intake) is associated with a higher total daily energy intake.
      Data were analyzed from 262 DONALD cohort study participants, who had completed
      at least one 3-day weighed dietary record in the age groups 3/4, 5/6, 7/8, 9/10,
      11/12, 13/14, 15/16 and 17/18 years (y). 'Eveningness in energy intake' was
      compared across age groups and related to total daily energy intake for each age
      group (multiple cross-sectional analyses). 'Eveningness' increased progressively
      from age group 3/4y to age group 17/18y. A median surplus of evening energy
      intake (i.e. when evening intake exceeded morning intake) was firstly observed
      for age group 11/12y. From age group 11/12y onwards, a higher 'eveningness' was
      associated with a higher total daily energy intake (all p < 0.04). Difference in
      total daily energy intake between the highest and the lowest tertile of
      'eveningness' was largest for age group 17/18y, amounting to an 11% higher intake
      among adolescents in the highest as compared to those in the lowest tertile. In
      conclusion, energy intake progressively shifts from morning to evening hours as
      children age. Once evening energy intake exceeds morning energy intake, a higher
      'eveningness in energy intake' is associated with higher total daily energy
      intake.

PMID- 29842969
TI  - Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to
      mesenchymal transition, proteolytic activity and IL-8 signaling.
AB  - Serglycin is an intracellular proteoglycan that is expressed and constitutively
      secreted by numerous malignant cells, especially prominent in the highly
      invasive, triple-negative MDA-MB-231 breast carcinoma cells. Notably, de novo
      expression of serglycin in low aggressive estrogen receptor alpha (ERalpha)
      positive MCF7 breast cancer cells promotes an aggressive phenotype. In this
      study, we discovered that serglycin promoted epithelial to mesenchymal transition
      (EMT) in MCF7 cells as shown by increased expression of mesenchymal markers
      vimentin, fibronectin and EMT-related transcription factor Snail2. These
      phenotypic traits were also associated with the development of drug resistance
      toward various chemotherapy agents and induction of their proteolytic potential
      as shown by the increased expression of matrix metalloproteinases, including MMP
      1, MMP-2, MMP-9, MT1-MMP and up-regulation of urokinase-type plasminogen
      activator. Knockdown of serglycin markedly reduced the expression of these
      proteolytic enzymes in MDA-MB-231 cells. In addition, serglycin expression was
      closely linked to a pro-inflammatory gene signature including the chemokine IL-8
      in ERalpha-negative breast cancer cells and tumors. Notably, serglycin regulated
      the secretion of IL-8 in breast cancer cells independently of their ERalpha
      status and promoted their proliferation, migration and invasion by triggering IL
      8/CXCR2 downstream signaling cascades including PI3K, Src and Rac activation.
      Thus, serglycin promotes the establishment of a pro-inflammatory milieu in breast
      cancer cells that evokes an invasive mesenchymal phenotype via autocrine
      activation of IL-8/CXCR2 signaling axis.

PMID- 29842970
TI  - Bypass for Innominate Artery Occlusive Disease.
AB  - The innominate artery, also known as the brachiocephalic artery, is the first
      vessel off the aortic arch and provides blood to the right arm, neck, and head.
      Occlusion of the innominate artery can be treated with endarterectomy,
      angioplasty, stenting, and bypass grafting. Bypass grafting describes a surgical
      procedure during which a bypass from the ascending aorta to the innominate artery
      is created. Our case depicts a patient post innominate artery bypass graft with a
      less commonly encountered postsurgical anatomy.

PMID- 29842971
TI  - Mechanically robust cryogels with injectability and bioprinting supportability
      for adipose tissue engineering.
AB  - : Bioengineered adipose tissues have gained increased interest as a promising
      alternative to autologous tissue flaps and synthetic adipose fillers for soft
      tissue augmentation and defect reconstruction in clinic. Although many
      scaffolding materials and biofabrication methods have been investigated for
      adipose tissue engineering in the last decades, there are still challenges to
      recapitulate the appropriate adipose tissue microenvironment, maintain volume
      stability, and induce vascularization to achieve long-term function and
      integration. In the present research, we fabricated cryogels consisting of
      methacrylated gelatin, methacrylated hyaluronic acid, and 4arm poly(ethylene
      glycol) acrylate (PEG-4A) by using cryopolymerization. The cryogels were
      repeatedly injectable and stretchable, and the addition of PEG-4A improved the
      robustness and mechanical properties. The cryogels supported human adipose
      progenitor cell (HWA) and adipose derived mesenchymal stromal cell adhesion,
      proliferation, and adipogenic differentiation and maturation, regardless of the
      addition of PEG-4A. The HWA laden cryogels facilitated the co-culture of human
      umbilical vein endothelial cells (HUVEC) and capillary-like network formation,
      which in return also promoted adipogenesis. We further combined cryogels with 3D
      bioprinting to generate handleable adipose constructs with clinically relevant
      size. 3D bioprinting enabled the deposition of multiple bioinks onto the
      cryogels. The bioprinted flap-like constructs had an integrated structure without
      delamination and supported vascularization. STATEMENT OF SIGNIFICANCE: Adipose
      tissue engineering is promising for reconstruction of soft tissue defects, and
      also challenging for restoring and maintaining soft tissue volume and shape, and
      achieving vascularization and integration. In this study, we fabricated cryogels
      with mechanical robustness, injectability, and stretchability by using
      cryopolymerization. The cryogels promoted cell adhesion, proliferation, and
      adipogenic differentiation and maturation of human adipose progenitor cells and
      adipose derived mesenchymal stromal cells. Moreover, the cryogels also supported
      3D bioprinting on top, forming vascularized adipose constructs. This study
      demonstrates the potential of the implementation of cryogels for generating
      volume-stable adipose tissue constructs and provides a strategy to fabricate
      vascularized flap-like constructs for complex soft tissue regeneration.

PMID- 29842972
TI  - Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate
      inks.
AB  - : Direct ink writing (DIW) techniques open up new possibilities for the
      fabrication of patient-specific bone grafts. Self-setting calcium phosphate inks,
      which harden at low temperature, allow obtaining nanostructured scaffolds with
      biomimetic properties and enhanced bioactivity. However, the slow hardening
      kinetics hampers the translation to the clinics. Different hydrothermal
      treatments for the consolidation of DIW scaffolds fabricated with an alpha
      tricalcium phosphate /pluronic F127 ink were explored, comparing them with a
      biomimetic treatment. Three different scaffold architectures were analysed. The
      hardening process, associated to the conversion of alpha-tricalcium phosphate to
      hydroxyapatite was drastically accelerated by the hydrothermal treatments,
      reducing the time for complete reaction from 7 days to 30 minutes, while
      preserving the scaffold architectural integrity and retaining the nanostructured
      features. beta-tricalcium phosphate was formed as a secondary phase, and a change
      of morphology from plate-like to needle-like crystals in the hydroxyapatite phase
      was observed. The binder was largely released during the treatment. The
      hydrothermal treatment resulted in a 30% reduction of the compressive strength,
      associated to the residual presence of beta-tricalcium phosphate. Biomimetic and
      hydrothermally treated scaffolds supported the adhesion and proliferation of rat
      mesenchymal stem cells, indicating a good suitability for bone tissue engineering
      applications. STATEMENT OF SIGNIFICANCE: 3D plotting has opened up new
      perspectives in the bone regeneration field allowing the customisation of
      synthetic bone grafts able to fit patient-specific bone defects. Moreover, this
      technique allows the control of the scaffolds' architecture and porosity. The
      present work introduces a new method to harden biomimetic hydroxyapatite 3D
      plotted scaffolds which avoids high-temperature sintering. It has two main
      advantages: i) it is fast and simple, reducing the whole fabrication process from
      the several days required for the biomimetic processing to a few hours; and ii)
      it retains the nanostructured character of biomimetic hydroxyapatite and allows
      controlling the porosity from the nano- to the macroscale. Moreover, the good in
      vitro cytocompatibility results support its suitability for cell-based bone
      regeneration therapies.

PMID- 29842973
TI  - Competency guidance for the provision of travel health services.

PMID- 29842974
TI  - Isolation and antimicrobial resistance of Escherichia coli isolated from farm
      chickens in Taif, Saudi Arabia.
AB  - OBJECTIVES: Poultry is one of the main sources of food in the world.
      Antimicrobial-resistant Escherichia coli can be transmitted to humans by contact
      with poultry waste or by contaminated poultry products, contributing to the
      increasing crisis of antimicrobial resistance. This study aimed to determine the
      incidence of antimicrobial resistance in E. coli isolated from chickens in Taif
      province, Saudi Arabia, and to identify the genes responsible for any resistance
      observed. METHODS: A total of 150 cloacal swabs were aseptically obtained from
      chickens from different farms, from which 180 colonies of E. coli were identified
      using standard microbiology procedures. Antimicrobial susceptibility testing was
      performed by the Kirby-Bauer disk diffusion method. The genes blaSHV, aac(3)-IV,
      tet(A), tet(B), aadA1, catA1, cmlA, ere(A) and sul1 were detected by PCR.
      RESULTS: Most of the E. coli isolates showed resistance to oxacillin (99%),
      lincomycin (98%) and oxytetracycline (97%). The prevalence of resistance to
      chloramphenicol (73%), ciprofloxacin (59%) and ampicillin (51%) was lower. Genes
      conferring resistance to beta-lactams (blaSHV) and tetracyclines [tet(A) and
      tet(B)] were observed at prevalences of 96% and 95%, respectively, among the E.
      coli isolates. Chloramphenicol (catA1 and cmlA) and erythromycin [ere(A)]
      resistance genes showed prevalences of 72% and 15%, respectively, whereas
      gentamicin [aac(3)-IV], streptomycin (aadA1) and sulfonamide (sul1) resistance
      genes were detected in 20%, 20% and 10% of the studied isolates, respectively.
      CONCLUSION: A significant prevalence of antimicrobial resistance genes was
      observed among E. coli isolates from farm chickens, supporting strict regulatory
      procedures for the use of antimicrobial agents.

PMID- 29842975
TI  - Prevalence and predictors of spontaneous bacterial peritonitis due to ceftriaxone
      resistant organisms at a large tertiary centre in the USA.
AB  - OBJECTIVES: The epidemiology of spontaneous bacterial peritonitis (SBP) due to
      ceftriaxone-resistant organisms has not been well studied in the USA. The primary
      objective of this study was to assess the prevalence and predictors of
      ceftriaxone-resistant SBP at a large US tertiary-care centre. METHODS: This 1:1:4
      case-case-control study included 141 adults with liver cirrhosis admitted from
      November 2011 to March 2016. Case group 1 were patients with SBP with a
      ceftriaxone-resistant organism (n=21). Case group 2 were patients with SBP with a
      ceftriaxone-susceptible organism (n=26). The control group were patients without
      SBP (n=94). Multiple logistic regression analysis was used to identify predictors
      of ceftriaxone-resistant SBP. RESULTS: Fifty isolates were identified from 47
      patients with culture-positive SBP (case groups 1 and 2). Of these 50 isolates,
      32 (64%) were Gram-negatives [mostly Enterobacteriaceae (91%)], 15 (30%) were
      Gram-positives and 3 (6%) were Candida spp. The prevalence of ceftriaxone
      resistance in patients with culture-positive SBP was 45% (21/47). The most common
      ceftriaxone-resistant organisms were ESBL-producing Enterobacteriaceae (45%).
      Independent predictors of ceftriaxone-resistant SBP included duration of beta
      lactam therapy in the past 90days (aOR=1.07, 95% CI 1.01-1.13) and recent
      invasive gastrointestinal procedure (aOR=12.47, 95% CI 2.74-56.67). CONCLUSIONS:
      The prevalence of ceftriaxone-resistant SBP was significant at a US tertiary
      centre. Local epidemiological data and identification of risk factors associated
      with ceftriaxone-resistant SBP, e.g. increased usage of previous beta-lactam
      therapy and invasive gastrointestinal procedure, may help clinicians identify
      patients requiring alternative empirical antibiotics.

PMID- 29842976
TI  - PNGM-1, a novel subclass B3 metallo-beta-lactamase from a deep-sea sediment
      metagenome.
AB  - OBJECTIVES: In order to find antimicrobial resistance gene(s) pre-dating the use
      of antibiotics through metagenomics, functional screening of a metagenomic
      library from the deep-seep sediments of Edison Seamount (ca. 10000 years old) was
      performed. METHODS: Among 60 antimicrobial-resistant clones, a single clone with
      the highest minimum inhibitory concentration (MIC) for ampicillin was selected.
      Sequence analysis revealed a new metallo-beta-lactamase (MBL) gene, designated as
      blaPNGM-1. PNGM-1 retains a zinc ion-binding motif (H116XH118XD120H121, H196 and
      H263), conserved in subclass B3 MBLs. The catalytic parameters of purified PNGM-1
      and the MICs of beta-lactams for Escherichia coli TOP10 transformants harbouring
      the blaPNGM-1 gene were assessed. RESULTS: Antimicrobial susceptibility testing
      indicated reduced susceptibility to penicillins, narrow- and extended-spectrum
      cephalosporins, and carbapenems in E. coli TOP10 transformants harbouring the
      blaPNGM-1 gene. In addition, kinetic analyses revealed that PNGM-1 hydrolysed
      almost all beta-lactams. CONCLUSIONS: The PNGM-1 enzyme is the first case of a
      subclass B3 MBL derived from a functional metagenomic library of a deep-sea
      sediment that pre-dates the antibiotic era.

PMID- 29842977
TI  - Antimicrobial resistance and genetic diversity of Salmonella Infantis isolated
      from foods and human samples in Morocco.
AB  - OBJECTIVES: Genotyping of Salmonella strains is an important molecular tool to
      discriminate isolates and to improve epidemiological studies when an outbreak
      occurs. Among the DNA-based genotyping methods, pulsed-field gel electrophoresis
      (PFGE) is currently used to subtype Salmonella isolates. In this study, the
      feasibility of genotyping Salmonella enterica serotype Infantis strains using
      XbaI restriction enzyme was evaluated. Separation of restricted fragments was
      performed by PFGE. METHODS: To test the possibility of applying this methodology
      to epidemiological investigation, a collection of 26 Salmonella Infantis strains
      were tested for their susceptibility to 14 antimicrobial agents and were analysed
      by XbaI macrorestriction followed by PFGE. Detection of class 1 integrons as well
      as intI1 and blaTEM genes in resistant strains was also studied. RESULTS:
      Antimicrobial susceptibility testing showed that 84.6% (22/26) of Salmonella
      Infantis isolates were susceptible to all of the antimicrobials tested, whereas
      7.7% (2/26) had low-level resistance to beta-lactams and harboured the blaTEM
      gene. A class 1 integron (0.8kb) and the intI1 gene (898bp) were detected in one
      Salmonella Infantis strain. However, five different PFGE profiles were defined by
      XbaI macrorestriction. CONCLUSIONS: The PFGE method demonstrated adequate typing
      ability and represents a powerful tool to discriminate the serotype Salmonella
      Infantis.

PMID- 29842978
TI  - High-frequency ultrasonic methods for determining corrosion layer thickness of
      hollow metallic components.
AB  - Corrosion in internal cavity is one of the most common problems occurs in many
      hollow metallic components, such as pipes containing corrosive fluids and high
      temperature turbines in aircraft. It is highly demanded to non-destructively
      detect the corrosion inside hollow components and determine the corrosion extent
      from the external side. In this work, we present two high-frequency ultrasonic
      non-destructive testing (NDT) technologies, including piezoelectric pulse-echo
      and laser-ultrasonic methods, for detecting corrosion of Ni superalloy from the
      opposite side. The determination of corrosion layer thickness below ~100 um has
      been demonstrated by both methods, in comparison with X-CT and SEM. With electron
      microscopic examination, it is found that with multilayer corrosion structure
      formed over a prolonged corrosion time, the ultrasonic NDT methods can only
      reliably reveal outer corrosion layer thickness because of the resulting acoustic
      contrast among the multiple layers due to their respective different mechanical
      parameters. A time-frequency signal analysis algorithm is employed to effectively
      enhance the high frequency ultrasonic signal contrast for the piezoelectric pulse
      echo method. Finally, a blind test on a Ni superalloy turbine blade with internal
      corrosion is conducted with the high frequency piezoelectric pulser-receiver
      method.

PMID- 29842979
TI  - Spatio-temporal distribution of PfMDR1 polymorphism among uncomplicated
      Plasmodium falciparum malaria cases along international border of north east
      India.
AB  - PfMDR1 single nucleotide polymorphisms (SNP) are good correlate markers for
      antimalarial drug resistance worldwide. Present study is a comprehensive view of
      screening of PfMDR1 polymorphism to antimalarials practiced with geography and
      time. Study sites Mizoram, Tripura, Meghalaya chosen are at multivariate drug
      pressure due to cross border migration and transmission. Mizoram is gateway to
      south east Asia through Myanmar whereas Tripura, Meghalaya share porous border
      with Bangladesh. Baseline finger pricked blood stained filter paper for confirmed
      uncomplicated Plasmodium falciparum infected patients (year 2015) were obtained
      from National Institute of Malaria Research, New Delhi, India. PfMDR1
      polymorphism for codon N86Y, Y184F, D1246Y was determined by PCR-RFLP, further
      confirmed by sequencing. There observed marked predominance of Plasmodium
      isolates with PfMDR1 wild type alleles for all codons under study i.e. 86, 184,
      1246. Spatially, Plasmodium isolates from Mizoram were most diverse with co
      existence of PfMDR1 genotype with NYD, YYD, NFD haplotypes, followed by Tripura.
      Isolates from Meghalaya were of all NYD haplotype. Reports, referring to
      screening of PfMDR1 SNPs to CQ/SP/AS-SP across India, were archived. Temporal
      study show distinct rise in proportion of PfMDR1 wild type N86 allele since
      introduction of Artemether-Lumefantrine as first line antimalarial. Hence spatio
      temporal screening of Plasmodium population with PfMDR1 single nucleotide
      polymorphism accounts for its association with antimalarial susceptibility and
      validate PfMDR1 SNPs as antimalarial drug resistant marker.

PMID- 29842980
TI  - Upsurge and spread of G3 rotaviruses in Eastern India (2014-2016): Full genome
      analyses reveals heterogeneity within Wa-like genomic constellation.
AB  - Advent of new strains and shift in predominantly circulating genotypes are
      characteristics of group- A rotavirus (RVA), one of the major causes of childhood
      gastroenteritis. During diarrheal disease surveillance at Kolkata, India (2014
      2016), a shift in circulating RVA strains from G1P[8] to G3P[8] was seen. Stool
      samples from children (n = 3048) with acute gastroenteritis were tested of which
      38.7% were RVA positive. G1 was the predominant strain (65.3%) in 2014-2015
      whereas in late 2015 and 2016, G3 became the preponderant strain (44.6%). In the
      past decade G3 strains were not observed in this region, we conducted whole
      genome sequencing of representative strains to gain insight into the phenomenon
      of emergence and genetic constellation of these circulating human G3 strains. The
      analyses revealed intergenogroup reassortment in G3P[4] strains (among Wa and DS
      1-like genogroup) whereas G3P[8] strains were authentic Wa-like. Phylogenetic
      analysis revealed Kolkata G3 strains as polymorphic and thus they formed two sub
      clusters due to antigenic differences in their VP7 protein. One of the sub
      clusters had the wild-type threonine at 87 amino acid position while another sub
      cluster had an isoleucine mutation. Presence of additional N-linked glycosylation
      site at amino acid 283 of VP7 glycoprotein suggests that the major neutralizing
      epitope on the VP7 (G3) of RotaTeq vaccine differs from the currently circulating
      G3 strains. The study is important as efficiency of rotavirus vaccine depends on
      the circulating heterogeneous genotype constellations. Continuous monitoring of
      circulating RVA strains in endemic settings like India is therefore important in
      pre- and post-vaccination period to monitor the emergence of new reassortant
      genotypes in addition to assessing vaccine efficacy.

PMID- 29842981
TI  - Genetic diversity of bat orthohepadnaviruses in China and a proposed new
      nomenclature.
AB  - The orthohepadnaviruses, which include the major human pathogen hepatitis B
      virus, exist in a wide range of hosts. Since 2013, a large group of
      orthohepadnaviruses has been identified in bats worldwide and classified as 4
      species within the genus Orthohepadnavirus. To further investigate
      orthohepadnaviruses in the Chinese bat population, 554 archived bat samples from
      20 colonies covering 3 southern provinces were screened with results showing that
      9 (1.6%) were positive. A systematic phylogenetic analysis has indicated the need
      for a new nomenclature for bat hepatitis B virus-like viruses: BtHBV, with the
      addition of 3 new species, one being divided into 6 genotypes. Viruses identified
      here shared 9.0-19.2% full genome divergence and classified into 3 different
      genotypes. This study illustrates the genetic diversity of orthohepadnaviruses in
      the Chinese bat population, and emphasizes need for further investigation of
      their public health significance.

PMID- 29842982
TI  - Mosquito-borne viral diseases and potential transmission blocking vaccine
      candidates.
AB  - Mosquito-borne viral diseases (MBVDs) have a complex biological cycle involving
      vectors and vertebrate hosts. These viruses are responsible for many deadly
      diseases worldwide. Although MBVDs threaten mostly developing countries, there is
      growing evidence indicating that they are also of concern in western countries
      where local transmission of arboviruses such as West Nile, Zika, Chikungunya and
      Dengue viruses have been recently reported. The rapid rise in human infections
      caused by these viruses is attributed to rapid climate change and travel
      facilities. Usually, the only way to control these diseases relies on the control
      of vectors in the absence of licensed vaccines and specific treatments. However,
      the overuse of insecticides has led to the emergence of insecticide resistance in
      vector populations, posing significant challenges for their control. An
      alternative method for reducing MBVDs can be the use of Transmission Blocking
      Vaccines (TBVs) that limits viral infection at the mosquito vector stage. Some
      successes have been obtained confirming the potential application of TBVs against
      viruses; however, this approach remains at the developmental stage and still
      needs improvements. The present review aims to give an update on MBVDs and to
      discuss the application as well as usage of potential TBVs for the control of
      mosquito-borne viral infections.

PMID- 29842983
TI  - eIF4A2 is a host factor required for efficient HIV-1 replication.
AB  - Host factors are required for efficient HIV-1 replication. To identify these
      factors, genome-wide RNA interference screening was performed using a human T
      cell line. In the present study, we assessed whether eukaryotic translation
      initiation factor 4A isoform 2 (eIF4A2), a DEAD-box protein identified in our
      screen, is necessary for efficient HIV-1 replication. Exploiting MT4C5 cells
      depleted of eIF4A2 by stable expression of eIF4A2-specific short-hairpin RNA
      (shRNA) using a lentiviral system, we found that depletion of eIF4A2 markedly
      inhibited the infection of a replication-competent reporter HIV-1. eIF4A2
      depletion reduced the efficiency of viral cDNA synthesis with virion entry into
      target cells being unaffected. Depletion of eIF4A2 also inhibited HIV-1 spreading
      infection in a knockdown level-dependent manner. These results suggest that HIV-1
      requires eIF4A2 for optimal replication in human T cells.

PMID- 29842984
TI  - On the role of retinoic acid in virus induced inflammatory response in cornea.
AB  - Ocular infection with herpes simplex virus (HSV) can result in a chronic immune
      inflammatory lesion that is a significant cause of human blindness. A key to
      controlling stromal keratitis (SK) lesion severity is to identify cellular and
      molecular events responsible for tissue damage and to counteract them. One
      potentially useful approach to achieve such therapy is Retinoic Acid (RA). Here
      we show that RA therapy reduces the severity of SK by having inhibitory effects
      on the T effector subtypes responsible for orchestrating SK. RA also served to
      stabilize the function of regulatory T cell (Treg) which counteract inflammatory
      cell activity. The Treg stabilizing effect was demonstrated by in vitro studies
      where RA was shown to retain Foxp3 expression when exposed to proinflammatory
      conditions such as IL-12 and IL-6+TGF-beta. in vivo studies revealed that RA
      exerted its stabilizing effects by downregulating IL-6R expression on Treg after
      HSV-1 infection and this helped to control the progression of SK. Since the
      therapy was effective when used both early and after the initiation of lesions,
      it may represent a valuable means of therapy when used alone or along with
      additional therapies.

PMID- 29842985
TI  - Inflammasome components caspase-1 and adaptor protein apoptosis-associated speck
      like proteins are important in resistance to Cryptosporidium parvum.
AB  - Cryptosporidium spp. are opportunistic protozoan parasites that infect epithelial
      cells in the intestinal tract and cause a flu-like diarrheal illness. Innate
      immunity is key to limiting the expansion of parasitic stages early in infection.
      One mechanism in which it does this is through the generation of early cytokines,
      such as IL-18. The processing and secretion of mature IL-18 (and IL-1beta) is
      mediated by caspase-1 which is activated within an inflammasome following the
      engagement of inflammasome-initiating sensors. We examined how the absence of
      caspase-1 and caspase-11, the adapter protein Asc, and other inflammasome
      components affects susceptibility to cryptosporidial infection by these and other
      key cytokines in the gut. We found that Casp-11-/-Casp-1-/- knockout mice have
      increased susceptibility to Cryptosporidium parvum infection as demonstrated by
      the 35-fold higher oocyst production (at peak infection) compared to wild-type
      mice. Susceptibility correlated with a lack of IL-18 in caspase-1 and caspase1/11
      knockout mice, whereas IL-18 is significantly elevated in wildtype mice. IL-1beta
      was not generated in any significant amount following infection nor was any
      increased susceptibility observed in IL-1beta knockout mice. We also show that
      the adapter protein Asc is important to susceptibility, and that the caspase-1
      canonical inflammasome signaling pathway is the dominant pathway in C. parvum
      resistance.

PMID- 29842986
TI  - NIR-controlled morphology transformation and pulsatile drug delivery based on
      multifunctional phototheranostic nanoparticles for photoacoustic imaging-guided
      photothermal-chemotherapy.
AB  - Stimuli-responsive nanoparticles are focused to promote the pathological
      specificity and controlled therapeutic activation in biomedicine, but the
      multifunctional modulation remains challenging. Herein, size and morphology
      switchable phototheranostic nanoparticles are developed for photoacoustic (PA)
      imaging-guided photothermal-chemotherapy. Multifunctional polypyrrole (PPy)
      nanoparticles with the template of upper critical solution temperature (UCST)
      polymers are designed to achieve light-controlled pulsatile drug release and
      concurrent activation of photothermal therapy (PTT). Wherein the UCST-featured
      inner core is loaded with camptothecin (CPT), the outer corona is tethered with
      thermo-cleavable doxorubicin (DOX) prodrug and further in-situ coated with PPy,
      affording the resultant CPT@DOX-UCST/PPy nanoparticles. Upon 808 nm continuous
      laser illumination, significant heating generated from light-absorbable PPy
      results in DOX prodrug cleavage and considerable size swelling (~125-fold), which
      in turn promotes simultaneous dual drug release, and thus triggering the combined
      therapeutic activation of PTT and chemotherapy. When laser is switched off, the
      discontinued photothermal generation makes the nanoparticle shrink back, thereby
      avoiding the leakage of CPT and DOX. In vivo experiments demonstrate the
      favorable tumor accumulation and prolonged tumor retention (>24 h) for long-term
      PA imaging-guided combination therapy. Current multifunctional nanoparticles
      integrated with light-controlled swelling/shrinking and synergistic therapeutic
      activation/silence represent a promising platform for precision cancer
      theranostics.

PMID- 29842987
TI  - Green synthesis and characterizations of gold nanoparticles using Thyme and
      survey cytotoxic effect, antibacterial and antioxidant potential.
AB  - Nowadays, green chemistry methods are noticeable for synthesis metal
      nanoparticles due to affordable, easy and high reaction rate. In the present
      study gold nanoparticles (Au NPs) were eco-friendly synthesized using Thyme
      extract at the room temperature for 30 min to provide non-toxic, which can be
      used for different applications. Identifying properties of synthesized gold
      nanoparticles was done by various analytical technique including UV-Vis
      absorption spectroscopy approved presence of Au NPs in the solution, the
      functional groups of Thyme extract in the reduction and capping process of Au NPs
      are determined by FT-IR, Crystalline with the fcc plane approved by X-ray
      diffraction (XRD) pattern, energy dispersive spectroscopy (EDS) determined
      existence of elements in the sample, surface morphology, diverse shapes and size
      of present Au NPs were showed by scanning electron microscopy (SEM), atomic force
      microscopy (AFM) and Transmission electron microscopy (TEM). Beginning and end
      destroy temperature of the gold nanoparticles were determined by thermal
      gravimetric spectroscopy (TGA). In addition, antibacterial, antioxidant, and
      cytotoxicity properties of Au NPs were studied. Antibacterial activity of Au NPs
      was investigated on gram-positive (Bacillus) and gram-negative (Escherichia coli)
      by disk diffusion; also MIC (Minimum Inhibitory Concentration) and MBC (Minimum
      Bactericidal Concentration) were determined. DPPH free radical scavenging assay
      was used for antioxidant property and compared to butylated hydroxy toluene (BHT)
      as a standard antioxidant that showed high antioxidant activity. Synthesized Au
      NPs have great cell viability in a dose-depended manner and demonstrate that this
      method provided nontoxic for synthesis gold nanoparticles. The average diameter
      of synthesized Au NPs was about 35 nm.

PMID- 29842988
TI  - Moral hindsight for good actions and the effects of imagined alternatives to
      reality.
AB  - Five experiments identify an asymmetric moral hindsight effect for judgments
      about whether a morally good action should have been taken, e.g., Ann should run
      into traffic to save Jill who fell before an oncoming truck. Judgments are
      increased when the outcome is good (Jill sustained minor bruises), as Experiment
      1 shows; but they are not decreased when the outcome is bad (Jill sustained life
      threatening injuries), as Experiment 2 shows. The hindsight effect is modified by
      imagined alternatives to the outcome: judgments are amplified by a counterfactual
      that if the good action had not been taken, the outcome would have been worse,
      and diminished by a semi-factual that if the good action had not been taken, the
      outcome would have been the same. Hindsight modification occurs when the
      alternative is presented with the outcome, and also when participants have
      already committed to a judgment based on the outcome, as Experiments 3A and 3B
      show. The hindsight effect occurs not only for judgments in life-and-death
      situations but also in other domains such as sports, as Experiment 4 shows. The
      results are consistent with a causal-inference explanation of moral judgment and
      go against an aversive-emotion one.

PMID- 29842989
TI  - When learning goes beyond statistics: Infants represent visual sequences in terms
      of chunks.
AB  - Much research has documented infants' sensitivity to statistical regularities in
      auditory and visual inputs, however the manner in which infants process and
      represent statistically defined information remains unclear. Two types of models
      have been proposed to account for this sensitivity: statistical models, which
      posit that learners represent statistical relations between elements in the
      input; and chunking models, which posit that learners represent statistically
      coherent units of information from the input. Here, we evaluated the fit of these
      two types of models to behavioral data that we obtained from 8-month-old infants
      across four visual sequence-learning experiments. Experiments examined infants'
      representations of two types of structures about which statistical and chunking
      models make contrasting predictions: illusory sequences (Experiment 1) and
      embedded sequences (Experiments 2-4). In all four experiments, infants
      discriminated between high probability sequences and low probability part
      sequences, providing strong evidence of learning. Critically, infants also
      discriminated between high probability sequences and statistically-matched
      sequences (illusory sequences in Experiment 1, embedded sequences in Experiments
      2-3), suggesting that infants learned coherent chunks of elements. Experiment 4
      examined the temporal nature of chunking, and demonstrated that the fate of
      embedded chunks depends on amount of exposure. These studies contribute important
      new data on infants' visual statistical learning ability, and suggest that the
      representations that result from infants' visual statistical learning are best
      captured by chunking models.

PMID- 29842990
TI  - The development of human digital Meissner's and Pacinian corpuscles.
AB  - Meissner's and Pacinian corpuscles are cutaneous mechanoreceptors responsible for
      different modalities of touch. The development of these sensory formations in
      humans is poorly known, especially regarding the acquisition of the typical
      immunohistochemical profile related to their full functional maturity. Here we
      used a panel of antibodies (to specifically label the main corpuscular
      components: axon, Schwann-related cells and endoneurial-perineurial-related
      cells) to investigate the development of digital Meissner's and Pacinian
      corpuscles in a representative sample covering from 11 weeks of estimated
      gestational age (wega) to adulthood. Development of Pacinian corpuscles starts at
      13 wega, and it is completed at 4 months of life, although their basic structure
      and immunohistochemical characteristics are reached at 36 wega. During
      development, around the axon, a complex network of S100 positive Schwann-related
      processes is progressively compacted to form the inner core, while the
      surrounding mesenchyme is organized and forms the outer core and the capsule.
      Meissner's corpuscles start to develop at 22 wega and complete their typical
      morphology and immunohistochemical profile at 8 months of life. In developing
      Meissner's corpuscles, the axons establish complex relationships with the
      epidermis and are progressively covered by Schwann-like cells until they complete
      the mature arrangement late in postnatal life. The present results demonstrate an
      asynchronous development of the Meissner's and Pacini's corpuscles and show that
      there is not a total correlation between morphological and immunohistochemical
      maturation. The correlation of the present results with touch-induced cortical
      activity in developing humans is discussed.

PMID- 29842991
TI  - Key molecules in lymphatic development, function, and identification.
AB  - While both blood and lymphatic vessels transport fluids and thus share many
      similarities, they also show functional and structural differences, which can be
      used to differentiate them. Specific visualization of lymphatic vessels has
      historically been and still is a pivot point in lymphatic research. Many of the
      proteins that are investigated by molecular biologists in lymphatic research have
      been defined as marker molecules, i.e. to visualize and distinguish lymphatic
      endothelial cells (LECs) from other cell types, most notably from blood vascular
      endothelial cells (BECs) and cells of the hematopoietic lineage. Among the
      factors that drive the developmental differentiation of lymphatic structures from
      venous endothelium, Prospero homeobox protein 1 (PROX1) is the master
      transcriptional regulator. PROX1 maintains lymphatic identity also in the adult
      organism and thus is a universal LEC marker. Vascular endothelial growth factor
      receptor-3 (VEGFR-3) is the major tyrosine kinase receptor that drives LEC
      proliferation and migration. The major activator for VEGFR-3 is vascular
      endothelial growth factor-C (VEGF-C). However, before VEGF-C can signal, it needs
      to be proteolytically activated by an extracellular protein complex comprised of
      Collagen and calcium binding EGF domains 1 (CCBE1) protein and the protease A
      disintegrin and metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3).
      This minireview attempts to give an overview of these and a few other central
      proteins that scientific inquiry has linked specifically to the lymphatic
      vasculature. It is limited in scope to a brief description of their main
      functions, properties and developmental roles.

PMID- 29842992
TI  - Neurotrophins and Trk receptors in the developing and adult ovary of Coturnix
      coturnix japonica.
AB  - NGF, BDNF, NT-3 and their specific receptors TrkA, TrkB and TrkC are known to be
      involved in the development and maintenance of vertebrates' nervous system.
      However, these molecules play a role also in non-neuronal tissue, such as in the
      reproductive system. In this study we investigated the presence and localization
      of neurotrophins and Trk receptors to unravel their potential role in the
      developing and adult ovary of Japanese quail, a model species well suited for
      reproduction studies. Western blotting analysis on ovaries of three month old
      quails in the period of egg laying showed the presence of pro and mature forms of
      neurotrophins and splice variants of Trk receptors. Immunohistochemical
      investigation reported that in embryonic ovaries from the 9th day of incubation
      to the hatching NGF and NT-3 were observed in the cortical and medullar areas
      respectively, whereas Trk receptors were observed in both areas. In adult ovary,
      all NTs were detected in glandular stromal cells, NGF and NT-3 also in the
      nervous component. Regarding follicle components, NGF and BDNF were observed in
      oocytes and follicular cells. All TrK receptors were present in nervous
      components and only TrkA in glandular stromal cells. In follicles, TrkA was
      present in oocyte cytoplasm and TrkB in theca cells. The results suggest an
      involvement of the neurotrophin system in the quail ovary physiology, promoting
      the oocyte development and follicular organization in the embryo, as well as
      oocyte and follicular maturation in adults.

PMID- 29842993
TI  - Coexpression of p-IGF-1R and MMP-7 Modulates Panitumumab and Cetuximab Efficacy
      in RAS Wild-Type Metastatic Colorectal Cancer Patients.
AB  - INTRODUCTION: The coexpression of pIGF-1R and MMP-7 (double-positive phenotype,
      DP) correlates with poor overall survival (OS) in KRAS wild-type (WT) (exon 2)
      metastatic colorectal cancer (mCRC) patients treated with irinotecan-cetuximab in
      second/third line. METHODS: We analyzed two prospective biomarker design trials
      of newly diagnosed RAS-WT mCRC patients treated with panitumumab-FOLFOX6 (PULSE
      trial; NCT01288339) or cetuximab plus either FOLFOX6/FOLFIRI (POSIBA trial;
      NCT01276379). The main exposure was DP phenotype (DP/non-DP), as assessed by two
      independent pathologists. DP cases were defined by immunohistochemistry as >70%
      expression of moderate or strong intensity for both MMP-7 and pIGF-1R. Primary
      endpoint: progression-free survival (PFS); secondary endpoints: OS and response
      rate. PFS and OS were adjusted by baseline characteristics using multivariate Cox
      models. RESULTS: We analyzed 67 patients (30 non-DP, 37 DP) in the PULSE trial
      and 181 patients in the POSIBA trial (158 non-DP, 23 DP). Response rates and PFS
      were similar between groups in both studies. DP was associated with prolonged OS
      in PULSE (adjusted HR: 0.23; 95%CI: 0.11-0.52; P=.0004) and with shorter OS in
      POSIBA (adjusted HR: 1.67; 95%CI: 0.96-2.90; P=.07). CONCLUSION: A differential
      effect of anti-EGFRs on survival by DP phenotype was observed. Panitumumab might
      be more beneficial for RAS-WT mCRC patients with DP phenotype, whereas cetuximab
      might improve OS in non-DP.

PMID- 29842995
TI  - From mother to child: Maternal betrayal trauma and risk for maltreatment and
      psychopathology in the next generation.
AB  - The objective of this study was to investigate whether experiences of high
      betrayal trauma (BT; maltreatment by a parent/caregiver) during mothers' own
      childhoods may influence the intergenerational transmission of maltreatment and
      its associated psychopathology from mothers to their children. A prospective,
      longitudinal design was utilized to assess maternal physical and sexual betrayal
      trauma in relation to children's own maltreatment experiences, and child mood and
      behavioral symptoms during pre-adolescence. Data from 706 mothers and children
      who participated in the Longitudinal Studies of Child Abuse and Neglect
      (LONGSCAN) was analyzed, including: mothers' physical and sexual maltreatment
      histories, child protective services' documented physical and sexual maltreatment
      during children's first twelve years of life, and mother- and child-reports of
      child internalizing and externalizing symptoms at age 12. Children of mothers who
      survived high BT (maltreatment by a caregiver) were 4.52 times more likely to
      experience maltreatment than children of no BT mothers (mothers whom were not
      maltreated), and 1.58 times more likely than children whose mothers survived low
      BT (maltreatment by a non-caregiver). Higher levels of maternal physical BT
      significantly predicted more internalizing and externalizing symptoms in children
      at age 12, according to both mother (CBCL) and child (YSR) reports. More
      incidents of child physical maltreatment partially mediated associations between
      maternal physical BT and child symptoms. Incidents of sexual maltreatment also
      partially mediated associations between maternal sexual BT and child
      internalizing and externalizing symptoms (CBCL only). These findings have
      implications for understanding the role of betrayal trauma in perpetuating the
      cycle of maltreatment across generations.

PMID- 29842996
TI  - The role of sleep in adolescents' daily stress recovery: Negative affect
      spillover and positive affect bounce-back effects.
AB  - The present study examined the role of sleep in daily affective stress recovery
      processes in adolescents. Eighty-nine American adolescents recorded their
      emotions and stress through daily surveys and sleep with Fitbit devices for two
      weeks. Results show that objectively measured sleep (sleep onset latency and
      sleep debt) moderated negative affective responses to previous-day stress, such
      that stress-related negative affect spillover effects became more pronounced as
      amount of sleep decreased. Total sleep time and sleep debt moderated cross-day
      positive affect "bounce-back" effects. With more sleep, morning positive affect
      on days following high stress tended to bounce back to the levels that were
      common following low stress days. Conversely, if sleep was short following high
      stress days, positive affect remained low the next morning. No evidence for
      subjective sleep quality as a moderator of spillover/bounce-back effects was
      found. This research suggests that sleep quantity could relate to overnight
      affective stress recovery.

PMID- 29842994
TI  - Tumor-Specific Mitochondrial DNA Variants Are Rarely Detected in Cell-Free DNA.
AB  - The use of blood-circulating cell-free DNA (cfDNA) as a "liquid biopsy" in
      oncology is being explored for its potential as a cancer biomarker. Mitochondria
      contain their own circular genomic entity (mitochondrial DNA, mtDNA), up to even
      thousands of copies per cell. The mutation rate of mtDNA is several orders of
      magnitude higher than that of the nuclear DNA. Tumor-specific variants have been
      identified in tumors along the entire mtDNA, and their number varies among and
      within tumors. The high mtDNA copy number per cell and the high mtDNA mutation
      rate make it worthwhile to explore the potential of tumor-specific cf-mtDNA
      variants as cancer marker in the blood of cancer patients. We used single
      molecule real-time (SMRT) sequencing to profile the entire mtDNA of 19 tissue
      specimens (primary tumor and/or metastatic sites, and tumor-adjacent normal
      tissue) and 9 cfDNA samples, originating from 8 cancer patients (5 breast, 3
      colon). For each patient, tumor-specific mtDNA variants were detected and traced
      in cfDNA by SMRT sequencing and/or digital PCR to explore their feasibility as
      cancer biomarker. As a reference, we measured other blood-circulating biomarkers
      for these patients, including driver mutations in nuclear-encoded cfDNA and
      cancer-antigen levels or circulating tumor cells. Four of the 24 (17%) tumor
      specific mtDNA variants were detected in cfDNA, however at much lower allele
      frequencies compared to mutations in nuclear-encoded driver genes in the same
      samples. Also, extensive heterogeneity was observed among the heteroplasmic mtDNA
      variants present in an individual. We conclude that there is limited value in
      tracing tumor-specific mtDNA variants in blood-circulating cfDNA with the current
      methods available.

PMID- 29842997
TI  - Longitudinal associations between time spent using technology and sleep duration
      among adolescents.
AB  - Technology use has been the focus of much concern for adolescents' sleep health.
      However, few studies have investigated the bidirectional association between
      sleep duration and time spent using technology. The aim of this study was to test
      whether time spent using technology predicted shorter sleep duration, and/or vice
      versa using cross-lagged analyses over one year. Participants were 1620 high
      school students in the 8th and 9th grade at baseline from 17 public schools in
      three middle Sweden communities. Students completed questionnaires at school
      during the spring of 2015 and 2016. Time spent using technology was self-reported
      and sleep duration was calculated from reported bed-times, wake-times and sleep
      onset latency. Time spent using technology significantly predicted shorter
      subsequent sleep duration and vice versa. Public health advocates educating
      others about the negative impacts of technology on sleep must also be mindful of
      the opposite, that many young people may turn to technological devices when
      experiencing difficulty sleeping.

PMID- 29842998
TI  - Involvement of aquaporin NIP1;1 in the contrasting tolerance response to root
      hypoxia in Prunus rootstocks.
AB  - Prunus species have been classified as moderately sensitive to root hypoxia, but
      with a certain intrageneric tolerance degree to oxygen deficiency. Previously,
      RNA-seq analysis described the transcriptomic reconfiguration of two Prunus
      rootstocks contrasting to root hypoxia, which included the shift from aerobic to
      anaerobic metabolism. Here, we studied the relationship between lactate
      accumulation and the functionality of an aquaporin differentially expressed in
      'Mariana 2624', a plum-based (Prunus cerasifera x Prunus munsoniana) rootstock
      tolerant to root hypoxia stress, and 'Mazzard F12/1', a cherry-based (Prunus
      avium) rootstock sensitive to root hypoxia stress. In the root hypoxia-sensitive
      rootstock, higher levels of lactate and LDH1 gene expression were found in roots
      exposed to oxygen deprivation. Concomitantly, we detected an increase in the mRNA
      abundance of Prunus spp. NIP1;1, a putative lactic acid transporter.
      Intriguingly, the high expression of PruavNIP1;1 is not linked to a lower lactic
      acid content in the roots of 'Mazzard F12/1'. To study this phenomenon, we
      calculated the force required for the transit of a lactic acid molecule through
      Prunus spp. NIP1;1 channels. Comparing the calculated forces, we identified
      steric hindrances in PruavNIP1;1 given by the residues Phe107 and Trp88 in the
      NPA region and ar/R filter, respectively. The functionality of both channels was
      corroborated by the restoration of the lactic acid transport and the differential
      lactic acid sensitive-phenotypes of the yeast strain Deltajen1 complemented with
      PruavNIP1;1 and PrucxmNIP1;1. Our findings provide new insights into the
      mechanisms involved in determining hypoxia tolerance between closely related
      species, such as plum and cherry.

PMID- 29842999
TI  - Gallium(III) complexes of alpha-N-heterocyclic piperidylthiosemicarbazones:
      Synthesis, structure-activity relationship, cellular uptake and activation of
      caspases-3/7/9.
AB  - Two types of alpha-N-heterocyclic piperidylthiosemicarbazone ligands and related
      Ga(III) complexes were synthesized. The structure of Ga4 and Ga5 were
      characterized by X-ray single crystal diffraction. We generated the related alpha
      N-heterocycliperidinylthiosemicarbazone analogs to examine the effect of
      aldehydes or ketones in the Schiff base. The antitumor activity of both type
      ligands increased after coordination with gallium. Interestingly, the antitumor
      activity of gallium complexes containing pyridyl groups (first type ligands) is
      higher than that of pyrazine group-containing (second type ligands) complexes.
      Gallium complexes significantly depleted cellular iron, resulting in upregulation
      of transferrin receptor-1 and downregulation of ferritin. They also effectively
      activate the caspase family proteins (caspase-3/7/9), promote the release of
      cytochromes from the mitochondria, and ultimately lead to apoptosis.

PMID- 29843000
TI  - Gender differences in schizophrenia: A multicentric study from three Latin
      America countries.
AB  - This study was aimed to explore clinical differences between women and men with
      schizophrenia (SZ) in Latin-America. It was conducted in public mental health
      centers in Bolivia, Peru and Chile. Two hundred forty-seven SZ patients
      participated in the study, 83 (33.6%) were women and 115 (46.6%) were Aymara.
      Compared to men, SZ women had slightly lower negative symptoms, reported slightly
      less social cognitive impairments, lower Family Relationships scores and higher
      Sentimental Life scores, independently of marital status, illness duration, age
      at illness onset and type of mental health treatment. All these differences have
      been replicated in the Aymara subgroup except for Sentimental Life scores. Aymara
      SZ women reported to be significantly less adherent into treatment compared to
      Aymara men. SZ women were found to have a better clinical profile and higher
      sentimental life scores than men. However, while SZ women reported more impaired
      Family Relationships compared to men, they were found to receive less
      psychotherapy in addition to pharmacological treatment. SZ Aymara women were also
      identified as a specific subgroup that may be targeted for increased observance
      strategies.

PMID- 29843001
TI  - An evaluation of mindfulness-based childbirth and parenting courses for pregnant
      women and prospective fathers/partners within the UK NHS (MBCP-4-NHS).
AB  - : An evaluation of mindfulness-based childbirth and parenting courses for
      pregnant women and prospective fathers/partners within the UK NHS (MBCP-4-NHS).
      OBJECTIVE: To explore the usefulness within the National Health Service (NHS) of
      a brief (four week, ten hour) course based upon the Mindfulness Based Childbirth
      and Parenting (MBCP) programme (Duncan and Bardacke, 2010) described here as MBCP
      4-NHS. BACKGROUND: The National Maternity Review (2016) and report of The
      Independent Mental Health Taskforce to the NHS (2016a, 2016b) in England
      highlight the need for significant investment into perinatal mental health
      services, with the Government pledging funding to improve such services through a
      range of measures. Whilst the field of mindfulness during the perinatal period is
      in need of well controlled trials and studies exploring the mechanisms of action
      (Hall et al., 2016) the limited research to date supports the potential for
      mindfulness based interventions in pregnancy and the need for further scientific
      study in this area (Dhillon et al., 2017; Shi and Macbeth, 2017). Particularly
      because it may broaden women's repertoire of coping strategies with the potential
      to improve the developmental trajectory of both parents and infants (Dunn et al.,
      2012; Duncan and Bardacke, 2010; Vieten and Astin, 2008). However, most of the
      studies to date have involved lengthy courses of around 8-9 weeks (24 h)
      duration, which may not be feasible or economical within a UK NHS setting and
      therefore, would be unlikely to be adopted as routine practice. DESIGN: An
      initial pilot study to discover if MBCP-4-NHS is acceptable and feasible within
      NHS maternity services, comparing maternal and paternal pre and post intervention
      self-report measures of mental health to begin to explore the effectiveness of
      this intervention. SETTING: NHS antenatal education classes held in children's
      centres for expectant parents across Oxfordshire. PARTICIPANTS: All expectant
      parents receiving Oxfordshire maternity services between October 2014 and January
      2015 were invited to self-refer into the intervention, of which 155 individuals
      (86 women and 69 men) took part. INTERVENTION: 'MBCP-4-NHS' - A brief (four week,
      ten hour) course developed from the nine week Mindfulness Based Childbirth and
      Parenting (MBCP) intervention. MEASURES: Self-report measures of mental health
      including low mood/depression, mindfulness, stress, anxiety, pregnancy related
      distress and experiences. FINDINGS: The results showed a significant increase in
      both maternal and paternal mental health with women demonstrating a significant
      improvement in symptoms of stress, anxiety, depression, pregnancy-related
      distress, labour worry and positive and negative pregnancy experiences; and men
      improving significantly in symptoms of anxiety, depression and showing a trend
      for improvement in self-reported symptoms of perceived stress. CONCLUSIONS: This
      is a promising antenatal intervention that can be feasibly implemented within NHS
      which might have the potential to impact upon parental mental health and,
      therefore, possibly also the health of next generation. However, caution is
      needed interpreting these findings given that this study did not include an
      active control group. IMPLICATIONS FOR PRACTICE: This research provides a clear
      rationale and justification for a large randomised control trial of this
      intervention within the NHS, which should include a more diverse population,
      across multiple centres and should explore both the potential health benefits for
      parents and infants/children as well as potential economic costs/benefits.

PMID- 29843002
TI  - Isolation of primitive mouse extraembryonic endoderm (pXEN) stem cell lines.
AB  - Mouse blastocysts contain the committed precursors of the extraembryonic endoderm
      (ExEn), which express the key transcription factor Oct4, depend on LIF/LIF-like
      factor-driven Jak/Stat signaling, and initially exhibit lineage plasticity.
      Previously described rat blastocyst-derived ExEn precursor-like cell lines (XENP
      cells/HypoSCs) also show these features, but equivalent mouse blastocyst-derived
      cell lines are lacking. We now present mouse blastocyst-derived cell lines, named
      primitive XEN (pXEN) cells, which share these and additional characteristics with
      the XENP cells/HypoSCs, but not with previously known mouse blastocyst-derived
      XEN cell lines. Otherwise, pXEN cells are highly similar to XEN cells by
      morphology, lineage-intrinsic differentiation potential, and multi-gene
      expression profile, although the pXEN cell profile correlates better with the
      blastocyst stage. Finally, we show that pXEN cells easily convert into XEN-like
      cells but not vice versa. The findings indicate that (i) pXEN cells are more
      representative than XEN cells of the blastocyst stage; (ii) mouse pXEN, rather
      than XEN, cells are homologs of rat XENP cells/HypoSCs, which we propose to call
      rat pXEN cells.

PMID- 29843003
TI  - Interventions to reduce stigma towards people with severe mental illness:
      Systematic review and meta-analysis.
AB  - This review evaluates the evidence on what interventions are effective in
      reducing public stigma towards people with severe mental illness, defined as
      schizophrenia, psychosis or bipolar disorder. We included 62 randomised
      controlled trials of contact interventions, educational interventions, mixed
      contact and education, family psychoeducation programs, and hallucination
      simulations. Contact interventions led to small-to-medium reductions in
      stigmatising attitudes (d = 0.39, 95% CI: 0.22 to 0.55) and desire for social
      distance (d = 0.59, 95% CI: 0.37 to 0.80) post-intervention, but these were
      reduced after adjusting for publication bias (d = 0.24 and d = 0.40,
      respectively). Effects did not vary by type or length of contact. Effects at
      follow-up were smaller and not significant. Education interventions led to small
      to-medium reductions in stigmatising attitudes (d = 0.30, 95% CI: 0.14 to 0.47)
      and desire for social distance (d = 0.27, 95% CI: 0.08 to 0.46) post
      intervention. Small improvements in social distance persisted up to 6 months
      later (d = 0.27, 95% CI: 0.05 to 0.49), but not attitudes (d = 0.03, 95% CI: 
      0.12 to 0.18). The combination of contact and education showed similar effects to
      those that presented either intervention alone, and head-to-head comparisons did
      not show a clear advantage for either kind of intervention. Family
      psychoeducation programs showed reductions in stigma post-intervention (d = 0.41,
      95% CI: 0.11 to 0.70). The effectiveness of hallucination simulations was mixed.
      In conclusion, contact interventions and educational interventions have small-to
      medium immediate effects upon stigma, but further research is required to
      investigate how to sustain benefits in the longer-term, and to understand the
      active ingredients of interventions to maximise their effectiveness.

PMID- 29843004
TI  - An ultra-sensitive Abbott ARCHITECT(r) assay for the detection of hepatitis B
      virus surface antigen (HBsAg).
AB  - BACKGROUND: Critical to the identification of HBV infection and the prevention of
      transfusion transmitted disease is the sensitive and accurate detection of
      Hepatitis B virus surface antigen (HBsAg). Improvements in HBsAg assay
      sensitivity approaching the performance of nucleic acid testing (NAT) are
      essential to further reduce the detection window for acute HBV infection in
      regions where NAT is not widely available. OBJECTIVES AND STUDY DESIGN: An
      improved HBsAg assay on the fully-automated Abbott ARCHITECT(r) platform was
      developed to improve sensitivity, mutant and genotype detection. RESULTS: The
      analytical sensitivity of the improved prototype assay is 5.2 mIU/ml, which is
      3.86- to 14.54-fold more sensitive than comparator assays based on the WHO
      International Reference Standard. The enhanced sensitivity was also demonstrated
      with 27 HBV seroconversion panels, detecting more panel members (191 of 364) vs.
      the ARCHITECT(r) Qual I (144), Qual II (160) and PRISM(r) (148) HBsAg assays.
      Further, the assay detected 7 of 12 HBV DNA positive/HBsAg negative samples, and
      detected all evaluated mutants and genotypes with higher sensitivity than the
      comparator assays. The improvement in sensitivity did not diminish assay
      specificity, attaining 100% (95% CI, 99.97-100%) on 10,633 blood donors.
      CONCLUSIONS: An Abbott ARCHITECT(r) HBsAg assay with clinical performance
      approaching that of mini-pool NAT (approximately 100 copies/ml was developed. The
      assay has superior HBsAg mutant and genotype detection and specificity, all of
      which are important for the diagnosis and management of HBV infection.

PMID- 29843005
TI  - Spatial and temporal variation in vertical migration of dissolved 137Cs passed
      through the litter layer in Fukushima forests.
AB  - We examined spatial variation in vertical 137Cs flux from the litter layer using
      lysimeters combined with copper-substituted Prussian blue in two forests
      (deciduous broad-leaved and Japanese cedar (Cryptomeria japonica)), approximately
      40 km northwest of the Fukushima Daiichi Nuclear power plant. The study ran from
      August 2016 to February 2017 in three periods; summer (10 Aug-4 Oct), autumn (5
      Oct-30 Nov) and winter (1 Dec-27 Feb). Twenty-five and 15 lysimeters were
      installed in the deciduous broad-leaved and the Japanese cedar sites within 400
      and 300 m2 areas with 3-5 m intervals, respectively. The geometric means of the
      flux in the deciduous broad-leaved site were 0.51, 0.085 and 0.060 kBq/m2/month
      in summer, autumn and winter periods, respectively. In the Japanese cedar site,
      the mean fluxes were 0.45, 0.036 and 0.023 kBq/m2/month. The ratio of 137Cs flux
      during the survey period to litter 137Cs inventory was 6% and 1% on average in
      the deciduous broad-leaved and Japanese cedar sites, respectively. The 137Cs flux
      in the summer period was much larger than those in other periods, resulting from
      higher precipitation in the summer. Our fine scale observation with 5 m interval
      showed very large spatial variation in the 137Cs flux and the differences between
      maximum and minimum range from 8 to 104 times, but were mostly 20-25 times. The
      spatial variations in the 137Cs flux were affected positively by those in the
      litter 137Cs inventory and negatively by canopy openness.

PMID- 29843006
TI  - Simultaneous determination of parecoxib and its main metabolites valdecoxib and
      hydroxylated valdecoxib in mouse plasma with a sensitive LC-MS/MS method to
      elucidate the decreased drug metabolism of tumor bearing mice.
AB  - Parecoxib (PX), a prodrug of valdecoxib (VX), is an injectable selective COX-2
      inhibitor, and is recommended for the treatment of cancer pain. PX can be rapidly
      hydrolyzed into its active metabolite VX, and VX is further metabolized into
      hydroxylated valdecoxib (OH-VX) by cytochrome P450 enzymes. However, cancer
      patients have been reported to possess reduced drug metabolism ability, which
      might cause excessive drug accumulation. Such overdose of PX significantly
      increased the risk of renal safety and cardiovascular events. Therefore, it is
      necessary to elucidate the concentration profiles of PX and its metabolites in
      cancer status. In this study, a sensitive, rapid and specific LC-MS/MS method for
      quantification of PX, VX and OH-VX in the plasma of tumor bearing mouse was
      developed and validated. After protein precipitation, all the analytes were
      separated on an Agilent ZORBAX Extend-C18 HPLC column (2.1 * 100 mm, 3.5 MUm)
      with gradient elution. The analytes were detected by an electrospray negative
      ionization mass spectrometry in the multiple reaction monitoring mode. The
      transition m/z 369.0 -> 119.0, m/z 312.9 -> 117.9, m/z 329.0 -> 196.0, and m/z
      307.1 -> 161.3 were used for monitoring PX, VX, OH-VX and IS respectively. The
      calibration curves of the analytes showed good linearity over the concentration
      range of 3-3000 ng/mL for PX and VX, and 3-1000 ng/mL for OH-VX. Intra- and inter
      batch accuracies (in terms of relative error, RE < 9.9%) and precisions (in terms
      of relative standard deviation, RSD < 8.8%) satisfied the standard of validation.
      The matrix effect, recovery and stability were also within acceptable criteria.
      The method was successfully applied to the pharmacokinetics study of PX in tumor
      bearing mice, and PX and VX levels were found elevated with the growth of tumor
      volume, which might increase the risk of drug overdose.

PMID- 29843007
TI  - Simultaneous determination of tryptophan, kynurenine, kynurenic acid and two
      monoamines in rat plasma by HPLC-ECD/DAD.
AB  - A high-performance liquid chromatography method with a diode array and an
      electrochemical detection (HPLC-ECD/DAD) was developed to determine the levels of
      tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYA), 5-hydroxytryptamine (5
      HT) and 5-hydroxyindoleacetic acid (5-HIAA) in rat plasma. The prepared samples
      were separated on a BDS column (4.6 mm * 250 mm, 5 mm) with column oven
      temperature of 25  degrees C. The mobile phase consisted of 5% acetonitrile and a
      buffer solution, which contained 25 mmol/L sodium acetate and 0.01 mmol/L EDTA,
      adjusting pH to 4.5 with acetic acid, and it was pumped at a flow-rate of 1.0
      mL/min. KYN and KYA were measured by a variable wavelength detector at
      wavelengths 360 nm and 333 nm respectively, TRP and vanillic acid (as IS) both
      were measured at 280 nm. Determination of 5-HT and 5-HIAA was accomplished at the
      electrochemical working potential of 700 mV. Total run time was 14 min. Several
      parameters of the developed method were validated including linearity, accuracy
      precision, and stability. The results showed the established method had good LOD
      and separation for all of the five compounds and IS in the biological matrix. The
      method is simple, fast, economical and accurate. The analytical method and the
      results could provide a reference for the clinical and scientific research of
      depression.

PMID- 29843008
TI  - Calibration of the inertial consistency index to assess road safety on horizontal
      curves of two-lane rural roads.
AB  - One of every four road fatalities occurs on horizontal curves of two-lane rural
      roads. To this regard, many studies have been undertaken to analyze the crash
      risk on this road element. Most of them were based on the concept of geometric
      design consistency, which can be defined as how drivers' expectancies and road
      behavior relate. However, none of these studies included a variable which
      represents and estimates drivers' expectancies. This research presents a new
      local consistency model based on the Inertial Consistency Index (ICI). This
      consistency parameter is defined as the difference between the inertial operating
      speed, which represents drivers' expectations, and the operating speed, which
      represents road behavior. The inertial operating speed was defined as the
      weighted average operating speed of the preceding road section. In this way,
      different lengths, periods of time, and weighting distributions were studied to
      identify how the inertial operating speed should be calculated. As a result,
      drivers' expectancies should be estimated considering 15 s along the segment and
      a linear weighting distribution. This was consistent with drivers' expectancies
      acquirement process, which is closely related to Short-Term Memory. A Safety
      Performance Function was proposed to predict the number of crashes on a
      horizontal curve and consistency thresholds were defined based on the ICI. To
      this regard, the crash rate increased as the ICI increased. Finally, the proposed
      consistency model was compared with previous models. As a conclusion, the new
      Inertial Consistency Index allowed a more accurate estimation of the number of
      crashes and a better assessment of the consistency level on horizontal curves.
      Therefore, highway engineers have a new tool to identify where road crashes are
      more likely to occur during the design stage of both new two-lane rural roads and
      improvements of existing highways.

PMID- 29843009
TI  - Bicycle-related injuries among children treated in US emergency departments, 2006
      2015.
AB  - OBJECTIVE: One of the leading causes of non-fatal injury among children is
      bicycling. Past studies indicate that helmets are protective against bicycle
      related injuries and involvement of motor vehicles is associated with severe
      injuries, but research utilizing a nationally representative data set for this
      population and focusing on these risk factors does not exist. The objective of
      this study was to describe the epidemiology of bicycle-related injuries among
      children treated in hospital emergency departments (EDs) in the United States
      (US). METHODS: A retrospective analysis was conducted with data from the National
      Electronic Injury Surveillance System for children 5-17 years of age who were
      treated in US EDs from 2006 through 2015 for a bicycle-related injury. Helmet use
      and motor vehicle involvement were two variables that were created and coded
      using keyword searches of the case narratives. Rates of injuries over time were
      described. Multivariate logistic regression along with 95% confidence intervals
      (CIs) were used to contrast types of injuries sustained among injured helmet
      users with non-users. RESULTS: An estimated 2 219 742 (95% CI: 1 871 120-2 568
      363) children 5-17 years of age were treated in US EDs for bicycle-related
      injuries over the 10-year study period, an average of 608 injuries per day. Most
      injuries (45.7%) involved children 10-14 years of age. The rate of bicycle
      related injuries significantly decreased from 447.4 per 100 000 children in 2006
      to 321.1 per 100 000 children in 2015 (P < 0.001). Helmet use at the time of
      injury was significantly associated with lower likelihood of head and neck
      injuries (OR: 0.52 [95% CI: 0.40-0.59]) and hospitalizations (OR: 0.71 [95% CI:
      0.54-0.94]), but there was no significant change in the rate of injury among
      helmet users over the study period (P = 0.224). Motor vehicle involvement
      increased the odds of bicycle-related traumatic brain injuries (TBIs) (OR: 1.98
      [95% CI: 1.49-2.64]) as well as injury-related hospitalizations (OR: 4.04 [95%
      CI: 3.33-4.89]). CONCLUSIONS: Despite decreasing injury rates, bicycling remains
      an important source of injury for children. Helmet use has demonstrated
      significant protective effects for TBIs, head and neck injuries, and
      hospitalizations. Motor vehicle involvement increased the risk of
      hospitalization. More efforts are needed to promote use of helmets and to reduce
      the possibility of bicycle-motor vehicle collisions to prevent bicycle-related
      injuries among children.

PMID- 29843011
TI  - From Muller to mechanism: How LNT became the default model for cancer risk
      assessment.
AB  - This paper summarizes the historical and scientific foundations of the Linear No
      Threshold (LNT) cancer risk assessment model. The story of cancer risk assessment
      is an extraordinary one as it was based on an initial incorrect gene mutation
      interpretation of Muller, the application of this incorrect assumption in the
      derivation of the LNT single-hit model, and a series of actions by leading
      radiation geneticists during the 1946-1956 period, including a National Academy
      of Sciences (NAS) Biological Effects of Atomic Radiation (BEAR) I Genetics Panel
      (Anonymous, 1956), to sustain the LNT belief via a series of deliberate
      obfuscations, deceptions and misrepresentations that provided the basis of modern
      cancer risk assessment policy and practices. The reaffirming of the LNT model by
      a subsequent and highly influential NAS Biological Effects of Ionizing Radiation
      (BEIR) I Committee (NAS/NRC, 1972) using mouse data has now been found to be
      inappropriate based on the discovery of a significant documented error in the
      historical control group that led to incorrect estimations of risk in the low
      dose zone. Correction of this error by the original scientists and the
      application of the adjusted/corrected data back to the BEIR I (NAS/NRC, 1972)
      report indicates that the data would have supported a threshold rather than the
      LNT model. Thus, cancer risk assessment has a poorly appreciated, complex and
      seriously flawed history that has undermined policies and practices of regulatory
      agencies in the U.S. and worldwide to the present time.

PMID- 29843012
TI  - Species removal from aqueous radioactive waste by deep-bed filtration.
AB  - Performances of aqueous suspension treatment by deep-bed sand filtration were
      experimentally studied and simulated. A semiempirical deterministic model and a
      stochastic model were used to predict the removal of clay particles (20 MUm) from
      diluted suspensions. Model parameters, which were fitted based on experimental
      data, were linked by multiple linear correlations to the process factors, i.e.,
      sand grain size (0.5 and 0.8 mm), bed depth (0.2 and 0.4 m), clay concentration
      in the feed suspension (1 and 2 kgp/m3), suspension superficial velocity (0.015
      and 0.020 m/s), and operating temperature (25 and 45  degrees C). These
      relationships were used to predict the bed radioactivity determined by the
      deposition of radioactive suspended particles (>50 nm) from low and medium level
      aqueous radioactive waste. A deterministic model based on mass balance, kinetic,
      and interface equilibrium equations was developed to predict the multicomponent
      sorption of 60Co, 137Cs, 241Am, and 3H radionuclides (0.1-0.3 nm). A removal of
      98.7% of radioactive particles was attained by filtering a radioactive wastewater
      volume of 10 m3 (0.5 mm sand grain size, 0.3 m bed depth, 0.223 kgp/m3 suspended
      solid concentration in the feed suspension, 0.003 m/s suspension superficial
      velocity, and 25  degrees C operating temperature). Predicted results revealed
      that the bed radioactivity determined by the sorption of radionuclides (0.01
      kBq/kgb) was significantly lower than the bed radioactivities caused by the
      deposition of radioactive particles (0.5-1.8 kBq/kgb).

PMID- 29843010
TI  - In utero exposure to fine particulate matter results in an altered neuroimmune
      phenotype in adult mice.
AB  - Environmental exposure to air pollution has been linked to a number of health
      problems including organ rejection, lung damage and inflammation. While the
      deleterious effects of air pollution in adult animals are well documented, the
      long-term consequences of particulate matter (PM) exposure during animal
      development are uncertain. In this study we tested the hypothesis that
      environmental exposure to PM 2.5 MUm in diameter in utero promotes long term
      inflammation and neurodegeneration. We evaluated the behavior of PM exposed
      animals using several tests and observed deficits in spatial memory without
      robust changes in anxiety-like behavior. We then examined how this affects the
      brains of adult animals by examining proteins implicated in neurodegeneration,
      synapse formation and inflammation by western blot, ELISA and
      immunohistochemistry. These tests revealed significantly increased levels of COX2
      protein in PM2.5 exposed animal brains in addition to changes in synaptophysin
      and Arg1 proteins. Exposure to PM2.5 also increased the immunoreactivity for
      GFAP, a marker of activated astrocytes. Cytokine concentrations in the brain and
      spleen were also altered by PM2.5 exposure. These findings indicate that in utero
      exposure to particulate matter has long term consequences which may affect the
      development of both the brain and the immune system in addition to promoting
      inflammatory change in adult animals.

PMID- 29843013
TI  - Lead-based paint in children's toys sold on China's major online shopping
      platforms.
AB  - Lead in paint is a major public health concern and has drawn much attention from
      international organizations such as the World Health Organization (WHO) and the
      United Nations Environmental Programme (UNEP). However, there is limited research
      on lead-based paint, especially its use in toys, which poses an explicit health
      risk to vulnerable children. The present study sampled 100 different toys
      purchased from the three largest online shopping platforms in China: JD, Taobao
      (TB) and Tmall (TM). These selected toys have been sold nearly 3 million times in
      total, suggesting that they may have reached the dwellings of millions of
      children. It was found that the toys sold by JD and TM, which are considered
      organized sellers, had average lead concentrations of 25 mg/kg and 32 mg/kg,
      respectively, much lower than that of toys sold by unorganized sellers on the TB
      platform, at 219 mg/kg. Approximately 12% of the toys purchased from TB contained
      paint with total lead concentrations exceeding China's regulatory standard for
      paints in toy manufacturing, and nearly 36% of the toys purchased from TB
      exceeded the equivalent US regulatory standard and EU standard. These results
      suggest that further action is needed to verify the health and safety standards
      of toys sold by such unorganized sellers. Moreover, this study found that China's
      regulatory standard (90 mg/kg) based on soluble lead may underestimate the risk
      posed by lead in paints, and it is suggested that future regulatory thresholds
      for lead levels in paints for toy manufacture be based on total rather than
      soluble lead concentrations. The present study also explored various influencing
      factors on lead concentration, and found that lead concentrations were related to
      toy price, age group, color, and sales volume.

PMID- 29843014
TI  - Fluorotelomer alcohols (FTOHs), brominated flame retardants (BFRs),
      organophosphorus flame retardants (OPFRs) and cyclic volatile methylsiloxanes
      (cVMSs) in indoor air from occupational and home environments.
AB  - Indoor air samples were collected from private homes and various occupational
      indoor environments using passive air sampler and analysed for fluorotelomer
      alcohols (FTOHs), brominated flame retardants (BFRs), organophosphorus flame
      retardants (OPFRs) and cyclic volatile methyl siloxanes (cVMSs). The aim was to
      investigate their occurrence in indoor air, factors that may affect their
      presence and human daily exposure dose (DED) via inhalation. In general, levels
      of cVMSs were 3-4 orders of magnitude greater than the other compound classes.
      OPFRs concentration was found significantly higher than BFRs in indoor air. The
      most abundant compounds in each chemical class were 8:2 FTOH, 2,4,6-TBP, TNBP and
      TCEP and decamethylcyclopentasiloxane (D5). Home samples contained higher level
      of FTOHs, BFRs and cVMSs than occupational environments, whereas concentration of
      OPFRs in office samples were higher. BFRs concentrations were significantly
      correlated with building age and with the number of electronic/electrical devices
      at the sampling sites. Moreover, significantly lower levels of FTOHs and cVMSs
      were observed in rooms with forced-ventilation system. Estimated DED via
      inhalation was significantly higher at home than in office and the total DED was
      on average 3-5 orders of magnitude lower than the reference value.

PMID- 29843015
TI  - Biotransformation of tetrabromobisphenol A dimethyl ether back to
      tetrabromobisphenol A in whole pumpkin plants.
AB  - As the metabolites of tetrabromobisphenol A (TBBPA), tetrabromobisphenol A mono-
      and di-methyl ethers (TBBPA MME and TBBPA DME) have been detected in various
      environmental media. However, knowledge of the contribution of plants to their
      environmental fates, especially to the interactions between TBBPA DME and TBBPA,
      is quite limited. In this study, the metabolism and behaviors of TBBPA DME was
      studied with pumpkin plants through 15-day hydroponic exposure. The TBBPA were
      also studied separately using in-lab hydroponic exposure for comparison. The
      results showed that more TBBPA DME accumulated in pumpkin roots and translocated
      up to stems and leaves compared with TBBPA. Transformation of TBBPA DME occurred
      later and more slowly than that of TBBPA. Interconversion between TBBPA DME and
      TBBPA was verified in intact plants for the first time. Namely, TBBPA DME can be
      biotransformed to TBBPA MME (transformation ratio in mole mass, TRMM 0.50%) and
      to TBBPA (TRMM 0.53%) within pumpkin; and TBBPA can be biotransformed to TBBPA
      MME (TRMM 0.58%) and to TBBPA DME (TRMM 0.62%). In addition, two single benzene
      ring metabolites, 2,6-dibromo-4-(2-(2-hydroxyl)-propyl)-anisole (DBHPA, TRMM
      3.4%) with an O-methyl group and 2,6-dibromo-4-(2-(2-hydroxyl)-propyl)-phenetole
      (DBHPP, TRMM 0.57%) with an O-ethyl group, were identified as the transformation
      products in the TBBPA exposure experiments. The transformation and
      interconversion from TBBPA DME back to TBBPA is reported as a new pathway and
      potential source for TBBPA in the environment.

PMID- 29843016
TI  - Abiotic, biotic and photolytic degradation affinity of 14 antibiotics and one
      metabolite - batch experiments and a model framework.
AB  - In this study, degradation affinities of 14 antibiotics and one metabolite were
      determined in batch experiments. A modelling framework was applied to decrypt
      potential ranges of abiotic, biotic and photolytic degradation coefficients. In
      detail, we performed batch experiments with three different sewages in the dark
      at 7  degrees C and 22  degrees C. Additionally, we conducted further batch
      experiments with artificial irradiation and different dilutions of the sewage at
      30  degrees C - de novo three different sewages were used. The batch experiments
      were initially spiked with a stock solution with 14 antibiotics and one
      metabolite to increase background concentrations by 1 MUg L-1 for each compound.
      The final antibiotic concentrations were sub-inhibitory with regard to sewage
      bacteria. The here presented modelling framework based on the Activated Sludge
      Model No. 3 in combination with adsorption and desorption processes. The model
      was calibrated with monitored standard sewage compounds before antibiotic
      degradation rates were quantified. The model decrypted ranges of abiotic, biotic
      and photolytic degradation coefficients. In detail, six antibiotics were not
      abiotic degradable at 7  degrees C, five antibiotics not at 22  degrees C and
      only 2 antibiotics at 30  degrees C. Finally, nine antibiotics were not
      significantly biodegradable at 7  degrees C and 22  degrees C. The model
      determined the link between adsorption characteristics and biodegradation rates.
      In detail, the rate was significantly affected by the bio-solid partition
      coefficient and the duration until adsorption was balanced. All antibiotics and
      the metabolite were photolytic degradable. In general, photolytic degradation was
      the most efficient elimination pathway of presented antibiotics except for the
      given metabolite and penicillin antibiotics.

PMID- 29843017
TI  - Blended capitation and incentives: Fee codes inside and outside the capitated
      basket.
AB  - Blended capitation physician payment models incorporating fee-for-service (FFS),
      pay-for-performance and/or other payment elements seek to avoid the extremes of
      both FFS and capitation. However, evidence is limited regarding physicians'
      responses to blended models, and potential shifts in service provision across
      payment categories within the practice. We examine the switch from FFS to a
      blended capitation-FFS model for primary care physicians in group practice. The
      empirical analysis shows patients experiencing 9-14% reductions in capitated
      services and simultaneous increases of 10-22% in FFS services from their
      rostering physicians. Unusually, our data permit changes among non-rostering
      physicians to be observed. Other physicians within the rostering group reduce the
      provision of capitated fee codes, with no net change in FFS services. All other
      physicians in the jurisdiction reduce both capitated and FFS services, which is
      consistent with patients concentrating their primary care with one provider as a
      result of capitation.

PMID- 29843018
TI  - Main and interaction effects of childhood trauma and the MAOA uVNTR polymorphism
      on psychopathy.
AB  - Psychopathy is characterized by callous affect, interpersonal manipulation, a
      deviant lifestyle, and antisocial behavior. Previous research has linked
      psychopathic traits to childhood trauma, but also to the upstream variable number
      tandem repeat (uVNTR) polymorphism of the monoamine oxidase A (MAOA) gene. An
      interaction between childhood trauma and MAOA genotype has been associated with
      antisocial behavior, but so far little is known about interaction effects of
      childhood trauma and the MAOA uVNTR on psychopathy. In order to bridge this gap,
      we used data of 1531 male and 1265 female twins and their siblings from a Finnish
      community sample to estimate structural equation models. The psychopathy and
      childhood trauma constructs were conceptualized as bifactor models with one
      general and two orthogonal group factors. Data comprised self-reports on
      childhood trauma and psychopathic traits as well as MAOA uVNTR genotype. In both
      genders, childhood trauma was associated with the general factor that represents
      the overarching psychopathy construct, and with the group factor that captures
      social deviance, but not with the group factor capturing psychopathic core
      personality traits. Women with a low activity variant of the MAOA uVNTR reported
      slightly higher levels of psychopathy than those with a high activity allele, but
      only with respect to the general psychopathy factor. There was no evidence for an
      interaction effect between MAOA uVNTR genotype and childhood trauma on
      psychopathy in either gender. Our results suggest that psychopathy in general and
      social deviance in particular are associated with childhood trauma in men and
      women, and that psychopathic traits are subject to variation in the MAOA uVNTR
      genotype in women.

PMID- 29843019
TI  - Endoplasmic reticulum stress in bipolar disorder? - BiP and CHOP gene expression-
      and XBP1 splicing analysis in peripheral blood.
AB  - BACKGROUND: Endoplasmic Reticulum stress activates the Unfolded Protein Response,
      which is partially impaired in Bipolar Disorder (BD) according to previous in
      vitro studies. Thus, BiP and CHOP gene expression and XBP1 splicing were analyzed
      in peripheral blood of study participants with BD and controls. METHODS: RNA was
      isolated from fasting blood of study participants with BD (n = 81) and controls
      (n = 54) and reverse transcribed into cDNA. BiP and CHOP gene expression was
      analyzed with quantitative RT-PCR. Atypical splicing of XBP1 mRNA was measured by
      semi-quantitative RT-PCR, gel-electrophoresis and densitometry. ANCOVAs with the
      covariates age, BMI, sex, lithium and anticonvulsants intake were used with SPSS.
      Bonferroni correction was used to correct for multiple testing (adjusted p =
      0.0083). RESULTS: BiP gene expression was significantly higher in BD than in
      controls (F(1/128) = 10.076, p = 0.002, Partial eta2 = 0.073). Total XBP1
      (F(1/126) = 9.550, p = 0.002, Partial eta2 = 0.070) and unspliced XBP1 (F(1/128)=
      8.803, p= 0.004, Patial eta2 = 0.065) were significantly decreased in BD. Spliced
      XBP1 (F(1/126) = 5.848, p = 0.017, Partial eta2 = 0.044) and the ratio spliced
      XBP1/ unspliced XBP1 did not differ between BD and controls (F(1/126) = 0.599, p
      = 0.441, Partial eta2 = 0.005). Gene expression did not differ between euthymia,
      depression and mania. DISCUSSION: BiP gene expression was significantly higher in
      BD compared to controls. Total and unspliced XBP1 were significantly lower in BD
      than in the control group. Thus, both genes may be considered as putative trait
      markers. Nevertheless, XBP1 splicing itself did not differ between both groups.

PMID- 29843020
TI  - Role of apoptosis in the Post-traumatic stress disorder model-single prolonged
      stressed rats.
AB  - Post-traumatic stress disorder (PTSD) is a stress-related mental disorder which
      occurs following exposure to traumatic events. A number of brain neuroimaging
      studies have revealed that PTSD patients have reduced volume and abnormal
      functions in the hippocampus and the amygdala. However, the pathogenesis of
      abnormalities in certain brain regions, as induced by PTSD, remains unclear.
      Recent studies, using the single prolonged stress (SPS) model, an animal model of
      PTSD, have found that abnormal apoptosis in certain brain regions, including the
      hippocampus, the amygdala, and the medial prefrontal cortex (mPFC); these areas
      are closely associated with emotion and cognition. In this review, we summarize
      the mechanism of apoptosis in SPS rats, including the endoplasmic reticulum (ER)
      and the mitochondria pathways. For the ER pathway, three individual pathways:
      PERK, IRE1, and ATF6 showed different roles on apoptosis and neuroprotection.
      Three key factors are thought to be involved in the mitochondrial pathway and
      PTSD-induced apoptosis: corticosteroid receptors, apoptosis-related factors, and
      anti-apoptosis factors. We have investigated the role of these factors and have
      attempted to identify which factors of the pathways are more focused towards
      neuronal protection, and which are more direct towards apoptosis. We also
      discussed the role of autophagy and the specific differences between autophagy
      and apoptosis in SPS rats. Finally, we discussed emerging researches related to
      anti-apoptosis treatment, including PERK inhibitors, IRE1 inhibitors, and
      metformin; collectively, these were exciting, but limited, This review provides a
      summary of the current understanding of apoptosis in SPS rats and the potential
      anti-apoptosis treatment strategies for PTSD.

PMID- 29843021
TI  - Self-assembled three-dimensional reduced graphene oxide-based hydrogel for highly
      efficient and facile removal of pharmaceutical compounds from aqueous solution.
AB  - Herein, self-assembled three-dimensional reduced graphene oxide (RGO)-based
      hydrogels were synthesized and characterized in detail. A thorough investigation
      on the uptake of three widely used pharmaceutical drugs, viz. Naproxen (NPX),
      Ibuprofen (IBP) and Diclofenac (DFC) was carried out from aqueous solutions. To
      ensure the sustainability of developed hydrogel assembly, practically important
      parameters such as desorption, recyclability and applicability to real samples
      were also evaluated. Using the developed 3D hydrogels as adsorptive platforms,
      excellent decontamination for the above mentioned persistent pharmaceutical drugs
      was achieved in acidic pH with a removal efficiency in the range of 70-80%. These
      hydrogels showed fast adsorption kinetics and experimental findings were fitted
      to different kinetic models, such as pseudo-first order, pseudo-second order,
      intra-particle and the Elovich models in an attempt to better understand the
      adsorption kinetics. Furthermore, equilibrium adsorption data was fitted to the
      Langmuir and Freundlich models, where relatively higher R2 values obtained in
      case of former one suggested that monolayer adsorption played an important part
      in drug uptake. Thermodynamic aspects were also studied and negative DeltaG0
      values obtained indicated the spontaneous nature of adsorption process. The study
      was also extended to check practical utility of as-prepared hydrogels by spiking
      real aqueous samples with drug solution, where high % recoveries obtained for
      NPX, IBP and DFC were of particular importance with regard to prospective
      application in wastewater treatment systems. We advocate RGO-based hydrogels as
      environmentally benign, readily recoverable/recyclable material with excellent
      adsorption capacity for application in wastewater purification.

PMID- 29843022
TI  - Investigating the target organs of novel anti-diabetic zinc complexes with organo
      selenium ligands.
AB  - Diabetes mellitus (DM) is a serious problem worldwide and is becoming
      increasingly prevalent. Previously, we reported the use of various zinc (Zn)
      complexes as new anti-diabetic agents. In this study, we synthesized novel organo
      selenium (Se) Zn complexes with hydroxy-pyrone derivatives that have a Zn(Se2O2)
      coordination mode. The results of in vitro insulin-mimetic analyses showed that
      the compound bis(3-hydroxy-2-methyl-4(H)-pyran-4-seleno)Zn ([Zn(hmps)2])
      exhibited the strongest activity among all the complexes. In the in vivo studies
      of Zn complexes with 3-hydroxy-2-methyl-4(H)-pyran-4-one, maltol, (hmpo)
      derivatives, [Zn(hmps)2] exhibited a stronger anti-diabetic effect than bis(3
      hydroxy-2-methyl-4(H)-pyran-4-one)Zn ([Zn(hmpo)2]), which had a Zn(O4)
      coordination mode. Additionally, we investigated the organ distribution of both
      Zn and Se by determining the amounts of these elements in the organs of
      [Zn(hmps)2]-administered mice. We then evaluated the effect of treatment with Zn
      complexes on hepatic lipid accumulation and pancreatic islet hypertrophy by
      hematoxylin and eosin (HE) histological staining. Zn complexes were found to
      improve the hypertrophy in the pancreas. There were some reports that Se
      containing Zn complexes such as di(2-selenopyridine-N-oxidato)Zn(II) ([ZPS]) were
      effective for treating diabetes mellitus, so in this study, we examined different
      types of zinc complexes with organo-selenium ligands.

PMID- 29843023
TI  - Differences in sleep functioning between individuals with seasonal affective
      disorder and major depressive disorder in Finland.
AB  - BACKGROUND: Sleep problems are commonly reported in seasonal affective disorder
      (SAD) and major depressive disorder (MDD). However, the specific characteristics
      of sleep difficulties differ. Frequent sleep problems in MDD are insomnia and
      night awakenings, whereas SAD patients complain of hypersomnia and daytime
      sleepiness. No previous studies have reported differences in sleep functioning
      between these two disorders. METHODS: We interviewed 4554 subjects from the
      Health 2011 survey and included 4153 individuals in this study. We selected
      participants who fulfilled the criteria for SAD (n = 223), nonseasonal-MDD (n =
      238), SAD + MDD (n = 65), and controls (n = 3627). They completed the World
      Health Organization Composite International Diagnostic Interview, Munich version
      (M-CIDI), the Seasonal Pattern Assessment Questionnaire (SPAQ), The Beck
      Depression Inventory (BDI), the EuroQoL (EQ-5), the Alcohol Use Disorders
      Identification Test (AUDIT) and several questions about sleeping, based on the
      Basic Nordic Sleep Questionnaire (BNSQ). RESULTS: We found Significant
      differences between groups for "enough sleep", "breathing interruptions during
      sleep", "tiredness during the day", and "sleeping difficulties". Controls
      reported better functioning in all sleep variables. SAD + MDD individuals showed
      more problems in "enough sleep" than SAD, more "breathing interruptions during
      sleep" than SAD and nonseasonal-MDD, felt more "tired during the day" than SAD
      and nonseasonal-MDD, and reported more "sleeping difficulties" than SAD and
      nonseasonal-MDD. Finally, nonseasonal-MDD individuals felt more "tired during the
      day" than SAD. CONCLUSION: Individuals with SAD + MDD show generalized sleeping
      problems. However, when SAD and nonseasonal-MDD appear separately, similar sleep
      functioning is observed. Nonseasonal-MDD subjects report to be more tired during
      the day than SAD.

PMID- 29843024
TI  - Profile of neuropsychological impairment in Sleep-related Hypermotor Epilepsy.
AB  - OBJECTIVE: The aim of this study was to characterize the neuropsychological
      features of a representative sample of Sleep-related Hypermotor Epilepsy (SHE)
      patients and to highlight clinical associations. METHODS: This cross-sectional
      study included 60 consecutive patients with video/video-electroencephalography
      documented SHE. All were assessed by measures of intelligence. Individuals with
      normal scores underwent a standardized battery of tests. The Fisher exact test
      and Wilcoxon rank-sum test for statistical analysis. RESULTS: Mean total IQ was
      96.96 +/- 21.50, with significant differences between verbal and performance
      scores (p < 0.0001). Nine patients (15%) had intellectual disability
      (ID)/cognitive deterioration. Of the 49 assessed by the extensive battery, 23
      (46.9%) showed deficits in at least one test evaluating phonemic fluency (24.5%),
      memory (24.5%), inhibitory control (22.4%), or working memory (10.2%). Patients
      with mutations in SHE genes had lower IQ than patients without mutations,
      irrespective of the specific gene (p = 0.0176). Similarly, pathological
      neurological examination (NE) and "any underlying brain disorder" (at least one
      among pathological NE, abnormal brain magnetic resonance imaging findings,
      perinatal insult) were associated with ID (p = 0.029, p = 0.036). A higher
      seizure frequency at last assessment and poor prognosis correlated with worse
      scores in visuo-spatial memory (p = 0.038, p = 0.040) and visuo-spatial abilities
      (p = 0.016). Status epilepticus (p = 0.035), poor response to antiepileptic drugs
      (p = 0.033), and poor prognosis (p = 0.020) correlated with lower shifting
      abilities, whereas bilateral convulsive seizures correlated with worse working
      memory (p = 0.049). CONCLUSION: In all, 53.3% of SHE patients had
      neuropsychological deficits. The profile of impairment showed worse verbal IQ, as
      well as deficits in extrafrontal and selective frontal functions. Our data
      support the contribution of genetics in ID by different biological mechanisms.
      Variables of clinical severity affect memory and executive functioning.

PMID- 29843025
TI  - Occurence of legacy and novel brominated flame retardants in food and feed in
      France for the period 2014 to 2016.
AB  - Determination of the occurrence levels of legacy and novel BFRs is today required
      to better understand the trends of BFRs contamination in food consecutive to the
      EU PBDEs restrictions and to proceed to a recent human food exposure in parallel.
      Therefore, concentrations of a large set of brominated flame retardants (BFRs) (n
      = 27) including PBDEs, HBCDDs, TBBPA and novel flame retardants (nBFRs) have been
      determined in more than 600 food and feed samples collected between 2014 and 2016
      in the context of French monitoring plans. Although legacy BFRs had already been
      studied in France, such a survey constituted the very first determination of
      nBFRs occurrence in foodstuffs at the national level. The concentration levels
      measured in fish and fish products were in general higher than in the other food
      categories. PBDEs were detected in 70% of the samples and were observed as the
      most abundant congeners (representing 80% of the sum of the monitored BFRs),
      while alpha-HBCDD could also be considered as a predominant congener (up to 26%
      of the sum of the monitored BFRs in fishes). nBFRs concentration levels were most
      of the time below the LOQ, except PBT, PBBz and HBBz which were more frequently
      detected at low levels. Also investigated in the study, BRPs exhibited high
      concentration levels in crustaceous (maximum value > 2700 pg/g ww).

PMID- 29843026
TI  - Polyethylenimine-functionalized silk sericin beads for high-performance
      remediation of hexavalent chromium from aqueous solution.
AB  - The enhancement of the metal adsorption and remediation performance of biomass
      based adsorbents is an important challenge in heavy metal removal processes. One
      of the most viable and practical approaches in accomplishing a high metal removal
      efficiency is the surface modification of natural polymer adsorbents with
      functional polymeric materials. In the present study, polyethylenimine (PEI)
      modified silk sericin beads were fabricated. The PEI modification process was
      confirmed and analyzed by Fourier transform infrared spectroscopy (FTIR), field
      emission-scanning electron microscopy (FE-SEM), and energy-dispersive X-ray
      spectroscopy (EDS)-based elemental analysis. The Cr(VI) remediation capabilities
      of PEI-modified sericin beads were analyzed by testing Cr(VI) removal from
      contaminated water. The results show that the Cr(VI) removal capacity of PEI
      modified sericin beads was 365.3 mg/g, which is significantly higher than that of
      pristine sericin beads (34.56 mg/g). During the Cr(VI) removal process, Cr(VI)
      adsorption and reduction to Cr(III) occurred simultaneously. The results herein
      reveal that the synthesized PEI-modified sericin beads are a promising material
      for Cr(VI) adsorption and detoxification of aqueous solution.

PMID- 29843027
TI  - Reply to discussion by John Heinze on "occurrence, fate and environmental risk of
      linear alkylbenzene sulfonate in the langat and Selangor River basins, Malaysia".

PMID- 29843028
TI  - Simultaneous analysis of 310 pesticide multiresidues using UHPLC-MS/MS in brown
      rice, orange, and spinach.
AB  - In this study, we developed a multiresidue method for the analysis of 310
      pesticides in representative agricultural produce (brown rice, orange, and
      spinach) using ultra high performance liquid chromatography-tandem mass
      spectrometry (UHPLC-MS/MS) combined with a modified QuEChERS procedure. The
      optimal mobile phase composition (Methanol containing 5 mM ammonium formate and
      0.1% formic acid) produced high sensitivity and reliable results. Also, the
      relationship between injection volume and repeatability of peak area was
      investigated. Most of the target pesticides had a limit of quantitation under 10
      ng g-1, and correlation coefficients (r2) > 0.99 in matrix-matched standards
      within the range of 1-100 ng g-1. To validate the optimized method, recovery
      tests were performed with each of the crops at 10 and 50 ng g-1 spiking levels (n
      = 5). Satisfactory recoveries were achieved showing that 86.8-88.7% (at 10 ng g
      1) and 91.9-96.1% (at 50 ng g-1) of the pesticides met the validation criteria
      (recoveries in the range of 70-120% and relative standard deviation <= 20%).
      Fifteen compounds were found to show a loss of recovery due to adsorption by
      primary and secondary amine or graphite carbon black. In the case of brown rice,
      86.1% of pesticides showed an insignificant matrix effect (<+/-20%), while 35.2%
      and 41.6% of pesticides in orange and spinach were in that range, respectively.
      Sixteen apple samples from local markets were analyzed to evaluate the
      applicability of the optimized method. Nineteen pesticides were detected, of
      which the concentrations were lower than the maximum residue limit.

PMID- 29843029
TI  - Ferrihydrite-impregnated granular activated carbon (FH@GAC) for efficient
      phosphorus removal from wastewater secondary effluent.
AB  - Adsorptive removal of phosphorus from wastewater effluents has attracted
      attention because of its reduced sludge production and potential P recovery. In
      this study, we investigated granular activated carbons (GACs) impregnated with
      amorphous ferrihydrite (FH@GAC) for the sorption of phosphorus from aqueous
      solutions. Preoxidation of intact GAC surfaces using an oxidant (e.g.,
      hypochlorite) and strong acids (e.g., HNO3/H2SO4) was performed to create active
      functional groups (e.g., carboxyl or phenolic) for enhanced iron binding, leading
      to greater phosphorus uptake. Both the rate and the capacity of phosphorus
      sorption onto FH@GAC had significant, positive relationships (Pearson correlation
      coefficient r > 0.9) with the product of surface area and Fe content. The pseudo
      second-order reaction kinetics explained the P sorption rate better than the
      pseudo-first-order reaction kinetics, whereas the Langmuir model fit the P
      sorption isotherm better than the Freundlich model. The iron content in the
      FH@GAC increased significantly (>10 mg/g) when GAC (e.g., BMC1050) was
      preoxidized by a 1:1 (w/w) concentrated HNO3/H2SO4 mixture. The Langmuir maximum
      P sorption capacity of a functionalized FH@BMC1050 adsorbent prepared with acid
      pretreatment was estimated to be substantial (5.73 mg P/g GAC corresponding to
      526 mg P/g Fe). This sorption capacity was superior to that of a FH slurry,
      possibly because the nano-sized FH formed inside the GAC pores (<2.5 nm) can bind
      phosphate ions more effectively than FH aggregates. Fixed-bed column reactor
      operation with bicarbonate regeneration showed potential for efficient,
      continuous phosphorus removal by FH@GAC media.

PMID- 29843030
TI  - Adsorption of estrone with few-layered boron nitride nanosheets: Kinetics,
      thermodynamics and mechanism.
AB  - Boron nitride Nanosheets (BNNSs) was fabricated with a method of heating the
      mixture of boric acid and urea in N2 atmosphere and used to remove estrone (E1)
      from water. The obtained BNNSs exhibited a higher surface area of 896 m2/g, a
      large pore volume of 0.76 cm3/g, and only few layers (0.398 nm) with the boric
      acid and urea ratio of 1:80. The layer number of BNNSs decreased from 15 to 4
      with the mole ratio of boric acid and urea decreasing from 1:20 to 1:80, which
      was identified by SEM, TEM, AFM and BET measurements. More importantly, BNNSs
      presented an outstanding adsorption performance for estrone with the adsorption
      capacity of 249.15 mg E1/g BNNSs. The adsorption process could be best fitted by
      pseudo second-order kinetic model and the equilibrium data at different
      temperatures were well fitted by Langmuir isotherm model. The thermodynamics
      analysis revealed that E1 adsorption on BNNSs was spontaneous (DeltaG = -29.33 kJ
      mol-1), enthalpy-retarded (DeltaH = 29.75 kJ mol-1), entropy-driven (DeltaS =
      198.26 J mol-1 K-1), and mostly chemical adsorption. The adsorption rates of E1
      in water were sharply enhanced with thinner BNNSs as absorbents and removal
      efficiency by BN-60 regenerated after 6 times was above 95%, it was shown that
      the surface areas, mesopores and remarkable structure played important roles in
      the adsorption process. The firmness of E1 onto BNNSs and the stability of
      adsorption efficiency made BNNSs as a potential absorbent for efficient removal
      of E1 from wastewater.

PMID- 29843031
TI  - Activation of persulfate by homogeneous and heterogeneous iron catalyst to
      degrade chlortetracycline in aqueous solution.
AB  - This study investigates the removal of chlortetracycline (CTC) antibiotic using
      sulfate radical-based oxidation process. Sodium persulfate (PS) was used as a
      source to generate sulfate radicals by homogeneous (Fe2+) and heterogeneous (zero
      valent iron, ZVI) iron as a catalyst. Increased EDTA concentration was used to
      break the CTC-Fe metal complexes during CTC estimation. The influence of various
      parameters, such as PS concentration, iron (Fe2+ and ZVI) concentration, PS/iron
      molar ratio, and pH were studied and optimum conditions were reported. CTC
      removal was increased with increasing concentration of PS and iron at an equal
      molar ratio of PS/Fe2+ and PS/ZVI processes. PS/Fe2+ and PS/ZVI oxidation
      processes at 1:2 (500 MUM PS and 1000 MUM) molar ratio showed 76% and 94% of 1
      MUM CTC removal in 2 h. Further increased molar ratio 1:2 onwards, PS/Fe2+
      process showed a slight increase in CTC degradation whereas in PS/ZVI process
      showed similar degradation to 1:2 (PS/Fe) ratio at constant PS 500 MUM
      concentration. Slower activation of persulfate which indirectly indicates the
      slower generation of sulfate radicals in PS/ZVI process showed higher degradation
      efficiency of CTC. The detected transformation products and their estrogenicity
      results stated that sulfate radicals seem to be efficient in forming stable and
      non-toxic end products.

PMID- 29843032
TI  - Is it the time to study air pollution effects under environmental conditions? A
      case study to support the shift of in vitro toxicology from the bench to the
      field.
AB  - Air pollution and particulate matter are recognised cause of increased disease
      incidence in exposed population. The toxicological processes underlying air
      pollution associated effects have been investigated by in vivo and/or in vitro
      experimentation. The latter is usually performed by exposing cells cultured under
      submerged condition to particulate matter concentration quite far from
      environmental exposure expected in humans. Here we report for the first time the
      feasibility of a direct exposure of air liquid interface cultured cells to
      environmental concentration of particulate matter. Inflammatory proteins release
      was analysed in cell medium while differential expression of selected genes was
      analysed in cells. Significant association of anti-oxidant genes was observed
      with secondary and aged aerosol, while cytochrome activation with primary and
      PAHs enriched ultrafine particles. The results obtained clearly show the
      opportunity to move from the lab bench to the field for properly understanding
      the toxicological effects also of ultrafine particles on selected in vitro
      models.

PMID- 29843033
TI  - Application of persulfate-oxidation foam spraying as a bioremediation
      pretreatment for diesel oil-contaminated soil.
AB  - This study investigated a persulfate-bioaugmentation serial foam spraying
      technique to remove total petroleum hydrocarbons (TPHs) present in diesel
      contaminated unsaturated soil. Feeding of remedial agents by foam spraying
      increased the infiltration/unsaturated hydraulic conductivity of reagents into
      the unsaturated soil. Persulfate mixed with a surfactant solution infiltrated the
      soil faster than peroxide, resulting in relatively even soil moisture content.
      Persulfate had a higher soil infiltration tendency, which would facilitate its
      distribution over a wide soil area, thereby enhancing subsequent biodegradation
      efficiency. Nearly 80% of soil-TPHs were degraded by combined persulfate
      bioaugmentation foam spraying, while bioaugmentation foam spraying alone removed
      52%. TPH fraction analysis revealed that the removal rate for the biodegradation
      recalcitrant fraction (C18 to C22) in deeper soil regions was higher for
      persulfate-bioaugmentation serial foam application than for peroxide
      bioaugmentation foam application. Persulfate-foam spraying may be superior to
      peroxide for TPH removal even at a low concentration (50 mN) because persulfate
      foam is more permeable, persistent, and does not change soil pH in the
      subsurface. Although the number of soil microbes declines by oxidation
      pretreatment, bioaugmentation-foam alters the microbial population exponentially.

PMID- 29843034
TI  - Effects of two strobilurins (azoxystrobin and picoxystrobin) on embryonic
      development and enzyme activities in juveniles and adult fish livers of zebrafish
      (Danio rerio).
AB  - Azoxystrobin and picoxystrobin are two primary strobilurin fungicides used
      worldwide. This study was conducted to test their effects on embryonic
      development and the activity of several enzyme in the zebrafish (Danio rerio).
      After fish eggs were separately exposed to azoxystrobin and picoxystrobin from 24
      to 144 h post fertilization (hpf), the mortality, hatching, and teratogenetic
      rates were measured. Additionally, effects of azoxystrobin and picoxystrobin on
      activities of three important antioxidant enzymes [catalase (CAT), superoxide
      dismutase (SOD) and peroxidase (POD)] and two primary detoxification enzymes
      [carboxylesterase (CarE) and glutathione S-transferase (GST)] and malondialdehyde
      (MDA) content in zebrafish larvae (96 h) and livers of adult zebrafish of both
      sexes were also assessed for potential toxicity mechanisms. Based on the
      embryonic development test results, the mortality, hatching, and teratogenetic
      rates of eggs treated with azoxystrobin and picoxystrobin all showed significant
      dose- and time-dependent effects, and the 144-h LC50 values of azoxystrobin and
      picoxystrobin were 1174.9 and 213.8 MUg L-1, respectively. In the larval
      zebrafish (96 h) test, activities of CAT, POD, CarE, and GST and MDA content in
      azoxystrobin and picoxystrobin-treated zebrafish larvae increased significantly
      with concentrations of the pesticides compared with those in the control. We
      further revealed that azoxystrobin and picoxystrobin exposure both caused
      significant oxidative stress in adult fish livers and the changes differed
      between the sexes. Our results indicated that picoxystrobin led to higher
      embryonic development toxicity and oxidative stress than azoxystrobin in
      zebrafish and the male zebrafish liver had stronger ability to detoxify than that
      of the females.

PMID- 29843035
TI  - Novel sulfonated graphene oxide incorporated polysulfone nanocomposite membranes
      for enhanced-performance in ultrafiltration process.
AB  - A novel polysulfone (PSf) nanocomposite ultrafiltration (UF) membrane using
      sulfonated graphene oxide (SGO) as additives was fabricated and investigated. SGO
      nanoparticles were chemically synthesized from graphene oxide (GO) by using
      sulfuric acid (H2SO4) and were confirmed by Raman and Fourier transform infrared
      (FTIR) spectroscopy. The morphology of prepared membranes was characterized by
      scanning electron microscopy (SEM), energy dispersive x-ray (EDX) and atomic
      force microscopy (AFM). Results showed that adding small amount (less than 0.3
      wt%) of SGO improved wettability, porosity and mean pore size of PSf/SGO
      membranes compared to the pristine PSf membrane and significantly enhanced the
      water flux of SGO incorporated PSf membranes. In UF performance, the
      nanocomposite membrane prepared by adding 1.5 w/w% SGO of PSf (designated as
      M1.5) showed the highest water flux result, which was 125% higher than the
      control PSf membrane (no SGO addition). Interestingly, there was no trade-off
      between water flux and bovine serum albumin (BSA) rejection, i.e more than 98%
      BSA rejection. The addition of SGO hydrophilic additives also showed better
      results in long-term BSA separation performance. The enhancement of hybrid
      membrane's properties was attributed to the hydrophilicity of sulfonic acid group
      (SO3H) on the surface of SGO additive. This study suggested that the SGO
      nanoparticle is a promising candidate to modify the PSf UF membranes.

PMID- 29843036
TI  - Is the aquatic environment sufficiently protected from chemicals discharged with
      treated ballast water from vessels worldwide? - A decadal environmental
      perspective and risk assessment.
AB  - Ballast water managements systems (BWMS) installed on vessels may use active
      substances to inactivate or kill organisms in the ballast water. This paper
      provides new insights in this global issue - discharge of hazardous disinfection
      by-products with ballast water and related risk assessment for the environment.
      Considering the possible extent of this issue, the International Maritime
      Organization (IMO) engaged the Joint Group of Experts on the Scientific Aspects
      of Marine Environmental Protection (GESAMP)-Ballast Water Working Group (BWWG) to
      oversee the evaluation process of BWMS that make use of active substances to
      prevent negative effects. We analysed all BWMS that received IMO final approval
      over a decade until 2017 and provide an overview of active substances used for
      ballast water treatment and disinfection by-products in the discharged ballast
      water. A risk assessment was conducted using the GESAMP-BWWG methodology for two
      very different commercial ports (Koper, Slovenia and Hamburg, Germany). Some
      relevant chemicals (chloropicrin, monochloroacetic acid, and dibromoacetonitrile)
      and other chemicals (isocyanuric acid and sodium thiosulphate) reached levels of
      concern, indicating a risk for aquatic organisms after discharge of that ballast
      water. From this analysis, it became clear GESAMP-BWWG worst-case scenario
      assumptions do not fully account for the potential environmental risks. We
      provide recommendations how to make this risk assessment more robust, recommend
      further research, and urge for policy as well as regulatory responses.

PMID- 29843037
TI  - Wetlands with greater degree of urbanization improve PM2.5 removal efficiency.
AB  - In recent decades, China has experienced both rapid urbanization and heavy air
      pollution and the rapid urbanization trend would be continue in the next decade.
      Wetlands have been shown to be efficient in particle removal, primarily through
      dry deposition and leaf accumulation. Thus, a more comprehensive understanding of
      PM2.5 removal by wetlands during urbanization processes could inform urban
      planning. In the current study, three wetland plots, Cuihu Lake Park (CL), Summer
      Palace (SP), and Olympic Park (OP), were selected as low, medium, and highly
      degrees of urbanization site respectively based on the proportions of building
      and traffic district areas to compare the removal efficiencies. Results show the
      average dry deposition velocity in OP was significantly higher than CL and SP.
      Dry deposition is mainly influenced by meteorological conditions. Buildings and
      other infrastructure make the meteorological conditions conducive to deposition,
      resulting in higher wind velocity, higher temperature, and more intense
      turbulence between buildings. Variation in leaf accumulation was not
      statistically significant between the three plots, and plant species was the
      major factor affecting the amount of accumulation. The dry deposition
      contribution to particle removal increases with degree of urbanization. The
      average dry deposition accounted for 39.74%, 52.55%, and 62.75% at low, middle
      and high level respectively. Therefore, Wetlands with greater degree of
      urbanization improve PM2.5 removal efficiency primarily by accelerating the dry
      deposition process. The result emphasizes the importance of wetlands in particle
      removal in highly urbanized areas and thus more wetlands should be preserved
      and/or created during urban expansion.

PMID- 29843038
TI  - Chlorination of 5-fluorouracil: Reaction mechanism and ecotoxicity assessment of
      chlorinated products.
AB  - What happens to drugs in the chlorinating environment? Degradation products may
      vary in pharmacological profiles and in ecotoxicity potentials compared to the
      parent compound. This study combines synthesis, NMR spectroscopy, quantum
      chemical calculations, and toxicity experiments on Daphnia magna to investigate
      chemical fate of antineoplastic drug 5-fluorouracil (5-FU) in chlorinated
      environment, which is common in waste-water treatment procedures, but also
      endogenous in activated neutrophils. A reduction of toxicity (EC50 after 48 h is
      50% higher than for the parent 5-FU) was observed after the first chlorination
      step, in which a chlorohydrin 5-chloro-5-fluoro-6-hydroxy-5,6-dihydrouracil was
      formed. Further chlorination leads to N-chlorinated intermediate, that undergoes
      the pyrimidine ring opening reaction. The final product, 2-chloro-2-fluoro-3,3
      dihydroxypropanoic acid was obtained after the loss of the chlorinated urea
      fragment. This is the most potent compound in the reaction sequence, with
      toxicity parameter EC50, after 48 h, more than twice lower compared to the parent
      5-FU. Clearly, the contact time between chlorinating species and degradation
      products provide different ecotoxicological properties of reaction mixtures.
      Interplay between experimental and theoretical procedures, to properly describe
      reaction pathways and provide more information on toxicity profiles, is a way
      forward in environmental science research.

PMID- 29843039
TI  - Perceived family relationship quality and use of poly-tobacco products during
      early and late adolescence.
AB  - BACKGROUND: The role of family relationship in adolescent use of emerging tobacco
      products, which have become increasingly popular, is unknown. We examined the
      associations of perceived family relationship quality with current use of poly
      tobacco products including cigarettes, electronic cigarettes (e-cigarettes),
      waterpipe and smokeless tobacco in adolescents. METHODS: Data from a
      representative sample of 42,250 US grade 7-12 equivalent students (mean +/- SD
      age 14.6 +/- 1.9 years; 51.3% boys) from 75 randomly selected secondary schools
      in Hong Kong (2012-13) were analysed. Logistic regressions yielded adjusted odds
      ratios (AORs) for current (past 30-day) use of cigarettes, e-cigarettes,
      waterpipe, smokeless tobacco and poly-tobacco (>=2 products) in relation to
      perceived family relationship quality, adjusted for age, sex, perceived family
      affluence, parental education, family structure, parental and sibling smoking and
      secondhand smoke exposure at home. Subgroup analyses were conducted to compare
      the associations in early (aged <=14 years) versus late (>14) adolescents.
      RESULTS: The odds of current use increased with worse perceived family
      relationship quality with AORs (95% confidence interval) of up to 2.92 (2.32
      3.68) for cigarettes, 7.28 (4.71-11.2) for e-cigarettes, 5.04 (3.44-7.40) for
      waterpipe, 8.09 (4.87-13.4) for smokeless tobacco and 5.25 (3.45-8.01) for poly
      tobacco products use (all P for trend <.001). The associations for all tobacco
      use outcomes were stronger in early than late adolescents (all P for interaction
      <.001). CONCLUSIONS: Dose-response relationships were found between negatively
      perceived family relationship quality and current poly- and individual tobacco
      product use by Hong Kong Chinese secondary students. The associations were
      stronger for alternative tobacco products and in early adolescents.

PMID- 29843040
TI  - Transition to drug co-use among adolescent cannabis users: The role of decision
      making and mental health.
AB  - BACKGROUND: Co-use of cannabis and drugs other than cannabis (DOTC) influences
      the risk of experiencing cannabis disorders. Accordingly, we explored whether
      speed of transition to drug co-use, the number of DOTC used, and/or being an
      experimental cannabis-only user, a regular cannabis-only user, or a regular
      cannabis user who co-uses DOTC (i.e., cannabis-plus user) were associated with
      decision-making (DM), mental health disorder symptoms, or cannabis use-related
      characteristics. METHODS: We analyzed baseline data from a sub-sample of 266
      adolescent (ages 14 to 16) cannabis users (CU) participating in an ongoing
      longitudinal study. Assessments included semi-structured interviews, self-report
      questionnaires, and measures of drug use, DM (measured via the Iowa Gambling
      Task), mental health disorders, and cannabis use-related problems. RESULTS:
      Endorsing a larger number of mood disorders symptoms was associated with being a
      regular cannabis-plus user rather than a regular cannabis-only user (AOR = 1.08,
      C.I.95% 1.01, 1.15). Poorer DM was associated with a faster transition to co-use,
      such that for each one unit increase in DM performance, the years to onset of
      drug co-use increased by 1% (p = 0.032). Endorsing a larger number of cannabis
      use-related problems was positively associated with endorsing a larger number of
      DOTC used (p = 0.001). CONCLUSIONS: This study provides new evidence on the
      process of drug co-use among CU. Specifically, mood disorder symptoms were
      associated with use of DOTC among regular CU. Furthermore, poorer DM was
      associated with a faster transition to drug co-use. Poorer DM and mood disorder
      symptoms may aggravate or accelerate the onset of adverse consequences among
      adolescent CU.

PMID- 29843041
TI  - Endothelial growth factor receptor-targeted and reactive oxygen species
      responsive lung cancer therapy by docetaxel and resveratrol encapsulated lipid
      polymer hybrid nanoparticles.
AB  - Special targeted therapy like endothelial growth factor receptor (EGFR) targeted
      therapy is available for the treatment of advanced non-small cell lung cancer
      (NSCLC). Biodegradable core-shell lipid-polymer hybrid nanoparticles (LPNs) can
      combine the beneficial properties of lipid and polymeric NPs for controlled drug
      delivery. In the present study, epidermal growth factor (EGF) conjugated LPNs
      were fabricated to co-deliver docetaxel (DTX) and resveratrol (RSV). In vitro and
      in vivo studies demonstrated that EGF DTX/RSV LPNs have significant synergistic
      effects, best tumor inhibition ability and the lowest systemic toxicity. The
      results indicate that EGF DTX/RSV LPNs may be a promising strategy for treatment
      of NSCLC.

PMID- 29843042
TI  - Taxifolin binds with LXR (alpha & beta) to attenuate DMBA-induced mammary
      carcinogenesis through mTOR/Maf-1/PTEN pathway.
AB  - AIM: 7,12-dimethylbenz(a)anthracene(DMBA), a PAH derivative initializes cascades
      of signaling events that alters a variety of enzymes responsible for lipid and
      glucose homeostasis resulting in enhanced availability and consumption of energy
      producing molecules for the development of carcinogenesis. 3-hydroxy-3
      methylglutaryl-coenzyme A reductase (HMG-CoAR) is a key enzyme regulating the
      pathway of synthesis of cholesterol whereas liver-X-receptor (LXR) regulates
      lipid, carbohydrate metabolism in various malignancies including mammary
      carcinogenesis (MC). In this study Taxifolin (TAX), a potential flavanoid has
      been subjected to evaluate its anti-cancer potential on (MC). METHODS: We
      designed to screen the molecular docking analysis of TAX on LXRalpha, LXRbeta,
      HMG-CoAR, mTOR and PTEN using MAESTRO tool comparing with their reference
      ligands. MC was developed by the administration of DMBA in the air pouch (under
      the mammary fat pad) of the female Sprague-Dawley rats (55 days old). After 90
      days of cancer induction, the chemotherapeutic potential of TAX was evaluated by
      administering TAX at different doses (10, 20 and 40 mg/kg b.w./day). Then western
      blot and RT-qPCR analysis were performed for determination of the protein and
      mRNA expressions respectively. RESULTS: The docking analysis revealed significant
      interaction with LXR (alpha&beta), HMG-CoAR, mTOR and PTEN. The docking results
      were validated with the enzyme inhibition assay using HMG-CoAR (EC 1.1.1.34). TAX
      inhibited the HMG-CoAR activity with an IC50 value of 97.54 +/- 2.5 nM whereas
      the reference molecule pavastatin revealed an IC50 value of 84.35 +/- 1.2 nM.
      Moreover, TAX modulated the energy regulation on DMBA-induced MC in SD-rats by
      significantly restoring the cancer-induced alterations in body weight, tumor
      growth and lipid, lipoproteins, lipid metabolizing enzymes and glycolytic
      enzymes. TAX interacted with LXRs, HMG-CoAR, metabolic enzymes and restored the
      altered metabolism that accelerates uncontrolled cell proliferation in MC.
      Moreover, TAX also altered the mRNA and protein expressions of HMG-CoAR, LXR
      (alpha,beta), Maf1, PTEN, phosphoinositide 3-kinase (PI3K), Akt, mTOR, fatty acid
      synthase (FASN) and acetyl-CoA carboxylase 1 (ACC1) in a dose dependent manner.
      CONCLUSION: These results validate the anti-cancer potential of TAX in DMBA
      induced MC through LXR-mTOR/Maf1/PTEN axis.

PMID- 29843043
TI  - Resveratrol inhibits pulmonary fibrosis by regulating miR-21 through MAPK/AP-1
      pathways.
AB  - OBJECTIVE: To explore the molecular mechanism of Res in regulation of pulmonary
      fibrosis (PF). METHODS: Rats were injected with bleomycin (BLM) to establish a PF
      model and treated with resveratrol (Res) and/or miR-21 agomir. After 14 days,
      lung tissues were collected for Hematoxylin-eosin and Masson's staining, and real
      time quantitative polymerase chain reaction and Western blot were performed to
      detect fibrosis-related protein expression and the activation of the TGF
      beta1/Smad pathway. In vitro, MRC-5 cells were pretreated with TGF-beta1, Res,
      and/or miR-21 agomir. After 48 h, total soluble collagen was detected with a
      Sircol Soluble Collagen Assay. Subsequently, a miR-21 mimic was transfected into
      MRC-5 cells, and a luciferase reporter assay was employed to verify whether miR
      21 targeted Smad7. RESULTS: Res reversed the increased levels of miR-21 induced
      by BLM and alleviated serious PF symptoms, but agomiR-21 treatment effectively
      impaired the above manifestations. In vivo, miR-21 inhibited the decreases of TGF
      beta1 and p-Smad2/3 that were induced by Res. In vitro, miR-21 significantly
      disrupted the positive effect of Res on TGF-beta-induced collagen deposition, as
      well as the levels of Fn, alpha-SMA, p-Smad2, and Smad7. In addition, Smad7 was
      found to be a direct target of miR-21-5p. TGF-beta stimulation led to an enormous
      increase in p-c-Jun, c-Jun, and c-Fos, which were significantly reduced by Res.
      Finally, miR-21 sharply reduced the increased phosphorylation levels of ERK, JNK
      and p38 that were induced by Res. CONCLUSION: Res inhibits BLM-induced PF by
      regulating miR-21 through MAPK/AP-1 pathways.

PMID- 29843044
TI  - The antidepressant-like effects of Chaihu Shugan San: Dependent on the
      hippocampal BDNF-TrkB-ERK/Akt signaling activation in perimenopausal depression
      like rats.
AB  - Chaihu Shugan San (CSS), a traditional Chinese medicine formula, has been used to
      treat depression for hundreds of years. Recently, the antidepressant-like
      mechanism of CSS has been increasingly evaluated and demonstrated. However, there
      are few studies focused on the involvement of the neurotrophic system in
      mediating the antidepressant-like effects of CSS. Considering the high prevalence
      of perimenopausal depression around the world, the goal of the present study was
      to determine whether brain-derived neurotrophic factor (BDNF) signaling is
      required for the antidepressant-like effects of CSS in perimenopausal depressive
      like rats. The results indicate that CSS reverses depressive-like behaviors and
      attenuates the downregulation of BDNF in the hippocampus of perimenopausal rats
      exposed to chronic unpredictable mild stress (CUMS). We found that the TrkB
      antagonist K252 not only blocks the effects of CSS on behavioral improvement but
      also abolishes the activation of CSS in BDNF-TrkB signaling. As a result, the
      downstream targets of BDNF signaling, such as the ERK and Akt pathways, are
      significantly inhibited by K252a. Furthermore, CSS increases hippocampal
      neurogenesis, while K252a fully prevents this action. In conclusion, the present
      results demonstrate that the activation of the hippocampal BDNF-TrkB-ERK/Akt
      signaling pathway is required for the antidepressant-like effects of CSS on the
      depressive-like state during perimenopause. Additionally, this study also
      demonstrates that neurogenesis is required for the effects of antidepressants in
      aging perimenopausal animals and provides fundamental evidence for the clinical
      application of CSS.

PMID- 29843045
TI  - Drug metabolizing enzymes and their inhibitors' role in cancer resistance.
AB  - Despite continuous research on chemotherapeutic agents, different mechanisms of
      resistance have become a major pitfall in cancer chemotherapy. Although,
      exhaustive efforts are being made by several researchers to target resistance
      against chemotherapeutic agents, there is another class of resistance mechanism
      which is almost carrying on unattended. This class of resistance includes
      pharmacokinetics resistance such as efflux by ABC transporters and drug
      metabolizing enzymes. ABC transporters are the membrane bound proteins which are
      responsible for the movement of substrates through the cell membrane. Drug
      metabolizing enzymes are an integral part of phase-II metabolism that helps in
      the detoxification of exogenous, endogenous and xenobiotics substrates. These
      include uridine diphospho-glucuronosyltransferases (UGTs), glutathione-S
      transferases (GSTs), dihydropyrimidine dehydrogenases (DPDs) and thiopurine
      methyltransferases (TPMTs). These enzymes may affect the role of drugs in both
      positive as well negative manner, depending upon the type of tissue and cells
      present and when present in tumors, can result in drug resistance. However, the
      underlying mechanism of resistance by drug metabolizing enzymes is still not
      clear. Here, we have tried to cover various aspects of these enzymes in relation
      to anticancer drugs.

PMID- 29843046
TI  - Osteoactivin inhibits dexamethasone-induced osteoporosis through up-regulating
      integrin beta1 and activate ERK pathway.
AB  - BACKGROUNDS: Dexamethasone (Dex) is widely used in autoimmune diseases and
      inflammation treatment. A sever side effect of prolonged exposure to Dex is
      increased risk of osteoporosis (OP) or even femoral head necrosis, which would
      cause much suffer to patients. To reveal the mechanism behind this phenomenon,
      provide therapeutic guidance and potential target, we analyzed the inhibitory
      mechanism of Dex on osteogenesis of rat-BMSC. METHODS: Rat BMSC were obtained and
      characterized with FACS analysis. Osteogenesis and adipogenesis abilities were
      detected with Oil-O-Red staining, Alizarin Red staining and ALP activity
      analysis. These BMSC were then treated with Dex in combination with recombinant
      OA or not and detected for osteogenesis related gene expression with qRT-PCR.
      Protein interaction and expression were detected by Co-Immunoprecipitation and
      western blot. RESULTS: Osteoactivin (OA) could promote integrin beta 1 expression
      and interact with this protein physically, leading to ERK activation and
      promoting osteogenesis related genes' expression including Runx2, Col1a and OCN
      in BMSC. Dex, however, could block expression of several upstream genes of OA and
      decrease OA mRNA and protein level, and eventually suppress integrin beta1-ERK
      activation and lead to decreased osteogenesis, which could finally develop into
      OP. CONCLUSION: Recombinant OA treated BMSC exerted better osteogenesis potency
      even with Dex administration. This is because additional OA in medium counter
      acts with Dex's influence and rescued osteoblast differentiation via up
      regulating integrin beta1 and activate ERK/MAPK pathway which promotes
      osteogenesis. Hence, OA/integrin beta1 could serve as potential therapeutic
      target for OP.

PMID- 29843047
TI  - Melatonin ameliorates bisphenol A-induced perturbations of the prostate gland of
      adult Wistar rats.
AB  - Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that has been
      demonstrated to induce alterations in reproductive organs while melatonin (ML),
      an antioxidant, present in plants and animals, is capable of protecting against
      EDC-induced alterations. Adult male Wistar rats (average weight, 240 + 10 g) were
      divided into four groups of ten animals each: Rats in group I (control) received
      oral 0.2 ml 1% dimethyl sulfoxide (DMSO)/99% canola oil as vehicle; group II
      received intra-peritoneal 10 mg/kg BW/day ML. Group III received oral BPA
      dissolved in DMSO and solubilized in canola oil at 10 mg/kg BW/day. Group IV were
      treated with same dose of BPA as group III with a concomitant intra-peritoneal 10
      mg/kg BW/day ML. All treatments lasted for 14 days. BPA significantly increased
      the prostatic index of the rats while ML ameliorated it. BPA significantly
      increased serum levels of estrogen as well as prostate-specific antigen but
      decreased serum testosterone in the rats while concomitant treatment with ML
      ameliorated these alterations. Also, BPA caused vascular congestion, hyperplasia
      (functional, reactive and atypical) of prostatic epithelium as well as tubular
      atrophy the rats while ML attenuated the observed lesions. Decreased localization
      of alphaSmooth muscle actin, vimentin and S100 proteins were observed in the BPA
      treated rats while these decreases were ameliorated by ML. The present study has
      shown that sub-acute oral administration of BPA induced alterations in prostatic
      index, serum hormone levels, down-regulated protein localization and induced
      morphological lesions of the prostate gland in rats while concomitant treatment
      with intra-peritoneal ML ameliorated these conditions. Hence, low dose of ML can
      protect against BPA-induced toxicity of the prostate gland of rats.

PMID- 29843048
TI  - Reduction of the molecular chaperone binding immunoglobulin protein (BiP)
      accentuates the effect of aging on sleep-wake behavior.
AB  - Sleep and wake quality, quantity, and architecture become modified with aging.
      Sleep and wake quality decline coinciding with increased fragmentation of both
      states across aging. We have previously shown that this age-related decline in
      sleep-wake quality is associated with increased endoplasmic reticular (ER) stress
      and decreased expression of the major ER chaperone binding immunoglobulin protein
      (BiP). BiP, also known as glucose-regulated protein 78, plays a key role in
      controlling the cellular response to ER stress, acting as a regulator of a
      protein homeostatic signaling pathway known as the unfolded protein response.
      Induction of BiP during cellular stress is part of an adaptive prosurvival
      mechanism. Here, using mice heterozygous for BiP, we investigated the effect of
      reduced BiP expression on sleep-wake behavior across aging; complete knockdown of
      BiP is embryonic lethal. We report that BiP heterozygosity accentuates the aging
      sleep-wake phenotype. Sleep and wake fragmentation was more pronounced in the BiP
      heterozygotes across the 3 ages examined. In mice lacking 1 functional copy of
      BiP, we observed an age-related significant reduction in wake bout duration and
      increase in wake bout numbers during the active period, as well as an increase in
      non rapid eye movement and rapid eye movement bout numbers accompanied by reduced
      bout durations of both non rapid eye movement and rapid eye movement during the
      sleep period. In addition, we observed increased ER stress in orexin neurons and
      occurrence of aggregates immunopositive for orexin at the terminals and
      projections of orexin neurons in the middle-aged BiP heterozygotes. Taken
      together, our data indicate that a reduction in the molecular chaperone BiP
      impacts sleep architecture across aging and that orexin processing is likely to
      be affected.

PMID- 29843049
TI  - Tumor necrosis and clinical outcomes following neoadjuvant therapy in soft tissue
      sarcoma: A systematic review and meta-analysis.
AB  - BACKGROUND: The prognostic role of tumor necrosis following neoadjuvant therapy
      is established in bone sarcomas but remains unclear in soft tissue sarcomas
      (STS). METHODS: We searched MEDLINE, MEDLINE in progress, EMBASE and Cochrane to
      identify studies that investigated neoadjuvant therapy in STS. Studies were
      required to report survival data based on extent of necrosis, or provided
      individual patient data allowing estimation thereof. Hazard ratios (HR) for
      relapse-free (RFS) and overall survival (OS) and odds ratios (OR) for recurrence
      at 3 years and for death at 5 years were pooled in a random effect meta-analysis.
      Associations between patient characteristics and attainment of >=90% necrosis
      were explored. RESULTS: 21 studies comprising 1663 patients were included.
      Extremity tumors were most common (n = 1554; 93%). Induction regimens included
      chemotherapy with radiotherapy (n = 924; 56%), chemotherapy alone (n = 412; 25%),
      radiotherapy alone (n = 78; 5%), isolated limb perfusion (ILP) (n = 231; 14%),
      and targeted therapy/radiotherapy (n = 18; 1%). Patients with <90% necrosis had
      higher hazard of recurrence (hazard ratio [HR] 1.47; 95% CI: 1.06-2.04; p = 0.02)
      and death (HR 1.86; 95% CI: 1.41-2.46; p < 0.001). Risk of recurrence at 3 years
      (OR = 3.35; 95% CI: 2.27-4.92; p < 0.001) and of death at 5 years (OR 2.60; 95%
      CI: 1.59-4.26; p < 0.001) were similarly increased. Compared to other modalities,
      ILP was associated with higher odds of achieving >=90% necrosis (OR 12.1; 95% CI:
      3.69-39.88; p < 0.001). CONCLUSION: Tumour necrosis <90% following neoadjuvant
      therapy is associated with increased recurrence risk and inferior OS in patients
      with STS.

PMID- 29843050
TI  - Gram-negative synthase-dependent exopolysaccharide biosynthetic machines.
AB  - Bacteria predominantly exist as matrix embedded communities of cells called
      biofilms. The biofilm matrix is made up of a variety of self-produced
      extracellular components including DNA, proteins, and exopolysaccharides.
      Bacterial exopolysaccharides have been implicated in surface adhesion, resistance
      to antibiotics, and protection from host immune systems. Herein we review the
      structure and function of the proteins involved in the production of the Gram
      negative synthase-dependent exopolysaccharides: alginate, poly-beta(1,6)-N-acetyl
      d-glucosamine (PNAG), cellulose, and the Pel polysaccharide. We highlight the
      similarities and differences that exist at the molecular level in these synthase
      systems.

PMID- 29843051
TI  - Kangaroo mother care and infant biopsychosocial outcomes in the first year: A
      meta-analysis.
AB  - AIM: A systematic review and meta-analysis was conducted to examine the
      relationship between KMC and infant/toddler biopsychosocial outcomes. METHOD:
      PubMed, MEDLINE (OvidSP), MEDLINE in Process (OvidSP), Embase (OvidSP), PsycINFO
      (OvidSP), and AMED (OvidSP) were searched. Observational studies and randomized
      control trials through October 2015 that investigated the association between KMC
      intervention and infant/toddler biopsychosocial outcomes were included. Studies
      with <10 participants, those using skin-to-skin only during painful procedures or
      only on the day of birth, and those that did not report quantitative outcomes
      were excluded. Data were extracted by two coders and estimates were examined
      using random-effects. RESULTS: 3177 studies were screened with 13 meeting
      inclusion criteria and representing 5 child outcomes (cognitive, motor, self
      regulation, socio-emotional and temperament). Among LBW/premature neonates, KMC
      compared to conventional care was associated with improved infant self
      regulation. Moderated effects were identified for cognitive (duration of KMC) and
      motor development (duration of KMC, country-level mortality ratio, and infant
      gender). INTERPRETATIONS: KMC administered to vulnerable neonates during a
      sensitive period of brain development has a lasting impact on self-regulation
      skills later in infancy. Further research examining the longer-term effect of KMC
      on cognitive and motor development, socioemotional skills, and temperament is
      needed.

PMID- 29843052
TI  - Expression of cyp1a induced by benzo(A)pyrene and related biochemical and
      genotoxic biomarkers in the neotropical freshwater fish Prochilodus lineatus.
AB  - The goal of this work was to design specific cyp1a primers for the fish
      Prochilodus lineatus to study the expression of this gene and its relation to the
      activity of biotransformation phase I enzyme (ethoxyresorufin O-deethylase -
      EROD) and genotoxic damage after 6 and 24 h of benzo(a)pyrene (B(a)P)
      intraperitoneal injection. In comparison to fish injected only with canola oil
      (vehicle), the expression of cyp1a and EROD activity both in the liver and gills
      were significantly higher after 6 and 24 h of B(a)P injection. A significant
      increase in DNA damage was detected in liver and blood cells after 6 h of B(a)P
      injection and in the gill cells after both times, probably caused by intermediate
      metabolites of B(a)P. Thus, the expression of cyp1a and its relationship with the
      corresponding enzyme activity is a potential biomarker for evaluation P. lineatus
      exposure to organic compounds.

PMID- 29843053
TI  - Clinical and radiographic periodontal status and whole salivary cotinine, IL
      1beta and IL-6 levels in cigarette- and waterpipe-smokers and E-cig users.
AB  - The aim was to compare the clinical (plaque index [PI], bleeding on probing
      [BOP], probing pocket depth [PPD] and clinical attachment loss [CAL]) and
      radiographic (marginal bone loss [MBL]) periodontal parameters and whole salivary
      cotinine, interleukin (IL)-1beta and IL-6 levels among cigarette-smokers,
      waterpipe-smokers, E-cig users and never-smokers. In total, 154 male individuals
      (39 cigarette-smokers, 40 waterpipe-smokers, 37 E-cig users and 38 never-smokers)
      were included. Full mouth PI, BOP, PPD and CAL were measured on all teeth
      (excluding third molars); and MBL was measured in digital intra-oral radiographs.
      Unstimulated whole salivary flow rate (UWSFR) and whole salivary cotinine, IL
      1beta and IL-6 levels were measured. Group comparisons were performed using one
      way analysis of variance and Bonferroni post-hoc tests. P-values less than 0.05
      were considered statistically significant. There was no difference in UWSFR among
      the groups. Cotinine levels were significantly higher among cigarette- (P <
      0.001) and waterpipe-smokers (P < 0.001) and E-cig users (P < 0.001) than never
      smokers. IL-1beta (P < 0.01) and IL-6 (P < 0.01) levels were significantly higher
      among cigarette- and waterpipe-smokers than E-cig users and never-smokers. There
      was no difference in PPD, CAL, mesial and distal MBL and whole salivary IL-1beta
      and IL-6 levels among E-cig users and never-smokers. In conclusion, clinical and
      radiographic parameters of periodontal inflammation were poorer in cigarette and
      waterpipe smokers than E-cig users and never-smokers; and whole salivary cotinine
      levels were similar in all groups. Whole salivary IL-1beta and IL-6 levels were
      higher in cigarette- and waterpipe-smokers than E-cig users and never-smokers.

PMID- 29843054
TI  - Identification of Strawberry vein banding virus encoded P6 as an RNA silencing
      suppressor.
AB  - RNA silencing is a common mechanism that plays a key role in antiviral defense.
      To overcome host defense responses, plant viruses encode silencing-suppressor
      proteins to target one or several key steps in the silencing machinery. Here, we
      report that the P6 protein encoded by Strawberry vein banding virus (SVBV) is an
      RNA silencing suppressor through Agrobacterium-mediated co-infiltration assays.
      SVBV P6 protein can suppress green fluorescent protein (GFP) gene silencing
      induced by single-stranded RNA but not by double-stranded RNA. The P6 protein can
      also inhibit systemic silencing of GFP through interfering the systemic spread of
      GFP silencing signal. Subcellular localization study indicated that P6 protein
      formed irregular bodies and distributed in both cytoplasm and nucleus of
      Nicotiana benthamiana cells. Furthermore, deletion analysis indicated that a
      nuclear localization signal (NLS, aa 402-426) in the P6 protein is responsible
      for the silencing suppression efficiency. In addition, expression of the P6
      protein via a Potato virus X (PVX)-based vectors induced more severe mosaic
      symptoms in N. benthamiana leaves, and transgenic N. benthamiana plants
      expressing P6 showed obvious vein yellowing as well as severe mosaic symptoms in
      leaves. Taken together, our results demonstrates that SVBV P6 is a suppressor of
      RNA silencing, possibly acting at a upstream step for dsRNA generation.

PMID- 29843055
TI  - Aging may negatively impact movement smoothness during stair negotiation.
AB  - Stairs represent a barrier to safe locomotion for some older adults, potentially
      leading to the adoption of a cautious gait strategy that may lack fluidity. This
      strategy may be characterized as unsmooth; however, stair negotiation smoothness
      has yet to be quantified. The aims of this study were to assess age- and task
      related differences in head and body center of mass (COM) acceleration patterns
      and smoothness during stair negotiation and to determine if smoothness was
      associated with the timed "Up and Go" (TUG) test of functional movement. Motion
      data from nineteen older and twenty young adults performing stair ascent, stair
      descent, and overground straight walking trials were analyzed and used to compute
      smoothness based on the log-normalized dimensionless jerk (LDJ) and the velocity
      spectral arc length (SPARC) metrics. The associations between TUG and smoothness
      measures were evaluated using Pearson's correlation coefficient (r). Stair tasks
      increased head and body COM acceleration pattern differences across groups,
      compared to walking (p < 0.05). LDJ smoothness for the head and body COM
      decreased in older adults during stair descent, compared to young adults (p <=
      0.015) and worsened with increasing TUG for all tasks (-0.60 <= r <= -0.43).
      SPARC smoothness of the head and body COM increased in older adults, regardless
      of task (p < 0.001), while correlations showed improved SPARC smoothness with
      increasing TUG for some tasks (0.33 <= r <= 0.40). The LDJ outperforms SPARC in
      identifying age-related stair negotiation adaptations and is associated with
      performance on a clinical test of gait.

PMID- 29843056
TI  - Mast cell activators as novel immune regulators.
AB  - Mast cells are an important cell type of the innate immune system that when
      activated, play a crucial role in generating protective innate host responses
      after bacterial and viral infection. Additionally, activated mast cells influence
      lymph node composition to regulate the induction of adaptive immune responses.
      The recognition that mast cells play a beneficial role in host responses to
      microbial infection and induction of adaptive immunity has provided the rationale
      to evaluate mast cell activators for use as antimicrobials or vaccine adjuvants.
      This review summarizes the role of mast cell activators in antimicrobial
      responses while also discussing the use of different classes of mast cell
      activators as potent vaccine adjuvants that enhance the induction of protective
      immune responses.

PMID- 29843057
TI  - DNA-assisted synthesis of nickel cobalt sulfide nanosheets as high-performance
      battery-type electrode materials.
AB  - Nickel-cobalt sulfide (NiCo2S4) nanosheets were successfully fabricated by an
      environment-friendly hydrothermal method with the assistance of DNA molecules.
      Different morphological samples were prepared by adjusting the concentrations of
      DNA. The NiCo2S4 nanosheets derived from 0.2 MUg/mL DNA (denoted as DS2)
      exhibited a desirable mesoporous feature with superior electrochemical
      performance compared with other samples. As a battery-type electrode material, it
      exhibited a high specific capacity of 644C g-1 at the current density of 1 A/g,
      superior rate capability of 74.3% retention at 15 A/g and remarkable cycling
      stability of 90.5% after 1500 cycles. Thus, the electrode material of NiCo2S4
      nanosheets assisted by DNA molecule offered great potential in eco-friendly
      energy storage device applications.

PMID- 29843058
TI  - Synthesis of hierarchical hollow sodium titanate microspheres and their
      application for selective removal of organic dyes.
AB  - Titanate-based materials are attractive inorganic adsorbents for wastewater
      treatment. In this study, hierarchical hollow sodium titanate microspheres
      (HHSTMs) were successfully synthesized via a template-assisted method. Silica
      microspheres were selected as hard templates, with a uniformly smooth TiO2 shell
      first grown onto the surface of the SiO2 cores. Then, through an alkaline
      hydrothermal process, the silica core was removed and the TiO2 shell gradually
      converted into a sodium titanate shell with a preserved morphology. The as
      synthesized HHSTMs are constructed from twined nanobelts, with a high surface
      area of 308 m2 g-1. A typical organic dye, methylene blue, was employed to
      investigate the adsorption properties of the HHSTMs. The adsorption process
      matched well with the Langmuir isothermal model, with the maximum adsorption
      capacity of methylene blue reaching 443 mg g-1. Moreover, the resulting HHSTMs
      can be used to selectively capture of methylene blue from a cationic-anionic dye
      binary system due to their negatively charged surface. All adsorption processes
      were very fast and could complete in ten minutes.

PMID- 29843059
TI  - Effect of protein adsorption on the radial wicking of blood droplets in paper.
AB  - HYPOTHESES: (1) The equilibrium size and characteristics of a radially wicked
      fluid on porous material such as paper is expected to be dependent on the fluid
      properties and therefore could serve as a diagnostic tool. (2) The change in
      wicked stain size between biological fluids is dependent on a change in solid
      liquid surface interfacial energy due to protein adsorption. EXPERIMENTS: Sessile
      droplets of increasing volume of blood, its components, and model fluids were
      deposited onto paper and the equilibrium stain size after coming to a halt was
      recorded. The contact angle of fluid droplets on model cellulose surfaces was
      measured to quantify the effect that blood protein adsorption at the solid-liquid
      interface has on radially wicked equilibrium size. Finally the significance of
      droplet evaporation for the time scale of interest was analysed. FINDINGS: The
      final stain area of all fluids tested on paper scales remarkably linearly with
      droplet volume. Different fluids were compared and the gradient of this linear
      relation was measured. Model fluids varying in surface tension and viscosity all
      behave similarly and exhibit a constant gradient. Blood and its components
      produce smaller stains, demonstrated by lower gradients. The gradient is a
      function of protein concentration, thus the mechanism of this phenomenon was
      identified as protein adsorption at the cellulose-liquid interface. The slope of
      the area/volume relationship for droplets is an important quantitative
      mechanistic variable.

PMID- 29843060
TI  - Hollow mesoporous organosilica nanospheres templated with flower-like micelles of
      pentablock copolymers.
AB  - We present a facile preparation of hollow mesoporous organosilica nanospheres
      with well-defined, uniform mesopores by controlling the morphology of pentablock
      copolymer templates under acidic conditions. The CBABC type poly(lactic acid-co
      glycolic acid)-b-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene
      oxide)-b-poly(lactic acid-co-glycolic acid) (PLGA-b-PEO-b-PPO-b-PEO-b-PLGA)
      pentablock copolymers were synthesized via a step-growth and ring-opening
      polymerization method using Pluronic F68 and F108 as macro-initiators. Two kinds
      of pentablock copolymers, (LA45GA12)EO75PO30EO75(LA45GA12) and (LA28GA9)EO141PO54
      EO141(LA28GA9), were used as single soft templates to prepare mesoporous ethane
      silica and benzene-silica hollow nanospheres by sol-gel chemistry in acidic
      aqueous solutions. The inner cavity diameter was controlled up to ~20 nm by
      varying acidity and the chain length of the hydrophobic PLGA block without using
      additional swelling agents. The evolution of hollow nanospheres could be
      explained by single flower-like micelle template mechanism and the variation of
      morphology of pentablock copolymers upon solution acidity. Moreover, the amine
      functionalized hollow benzene-silica nanospheres showed high carbon dioxide
      adsorption at ambient conditions. The hollow organosilica nanospheres were
      characterized by small-angle X-ray scattering, nitrogen adsorption-desorption,
      solid-state 13C- and 29Si nuclear magnetic resonance, and scanning and
      transmission electron microscopy and so on.

PMID- 29843061
TI  - Controlled construction of gold nanoparticles in situ from beta-cyclodextrin
      based unimolecular micelles for in vitro computed tomography imaging.
AB  - The development of nanomaterials as highly efficient contrast agents for tumor
      computed tomography (CT) imaging still remains a huge challenge. In this study, a
      novel and facile approach to fabricate unimolecular micelles-stablized gold
      nanoparticles (AuNPs) without external reductant for in vitro targeted CT imaging
      was described. Amphiphilic 21-arm star-like polymers beta-cyclodextrin-g-{poly(2
      (dimethylamino)ethyl methacrylate)-poly(2-hydroxyethyl methacrylate)
      poly[poly(ethylene glycol) methyl ether methacrylate]} [beta-CD-g-(PDMA-b-PHEMA-b
      PPEGMA)] was firstly synthesized and proved to form unimolecular core-middle
      layer-shell-type micelles in water through experimental and computer simulation
      results. Taking advantage of the reducing groups of PDMA block, AuNPs were
      decorated in the micellar PDMA block because of the in situ reduction of gold
      ions, which were absorbed by the PDMA chains in the core layer with a narrow
      nanoparticle size distribution. This strategy could prevent aggregation of AuNPs,
      which were capable of being employing as a highly effective probe for specific CT
      imaging in vitro. Importantly, the beta-CD-g-(PDMA-b-PHEMA-b-PPEGMA)/AuNPs
      incubated with HepG2 cells, displayed more intense X-ray attenuation property
      (>37%) than conventional iodine-based CT imaging agent (Omnipaque) and also
      possessed a satisfying cytocompatibility in the given concentration range. The
      facile fabrication procedures and the efficiency of CT imaging render the novel
      hybrid unimolecular micelles to become potent candidates for applications in
      tumor-targeted CT imaging.

PMID- 29843063
TI  - Rupture of ultrathin solution films on planar solid substrates induced by solute
      crystallization.
AB  - On-line optical imaging of continuously thinning planar films in a spin cast
      configuration reveals the rupture behavior of ultra-thin films of binary mixtures
      of a volatile solvent and a nonvolatile solute. The pure solvents completely wet
      the silica substrates whereas the solution films rupture at certain film
      thicknesses, hrupture, which depend on, c0, the initial weighing in solute
      concentrations. With small c0, hrupture increases proportional to c0. With high
      c0, all films rupture at hrupture~50nm, independent of c0. The findings can be
      explained by the solute enrichment during the evaporative thinning. Solute
      crystallization at the liquid/substrate interface upon reaching solute
      supersaturation leads to locally different wetting properties. This induces
      locally the rupture of the film as soon as it is sufficiently thin. A proper data
      rescaling based on this scenario yields a universal rupture behavior of various
      different solvent/solute mixtures.

PMID- 29843062
TI  - Phosphate removal from aqueous solution using iron oxides: Adsorption, desorption
      and regeneration characteristics.
AB  - Dynamics of phosphate (PO43-) adsorption, desorption and regeneration
      characteristics of three lab-synthesized iron oxides, ferrihydrite (F), goethite
      (G), and magnetite (M) were evaluated in this study. Batch experiments were
      conducted to evaluate the impact of several adsorption parameters including
      adsorbent dosage, reaction time, temperature, pH, and ionic strength. The results
      showed that PO43- adsorption increased with reaction time and temperature while
      it decreased with an increase in solution pH. Adsorption isotherm data exhibited
      good agreement with the Freundlich and Langmuir model with maximum monolayer
      adsorption capacities of 66.6 mg.g-1 (F), 57.8 mg.g-1 (M), and 50.5 mg.g-1 (G). A
      thermodynamics evaluation produced DeltaG < 0, DeltaH > 0, and DeltaS > 0,
      demonstrating that PO43- adsorption onto tested minerals is endothermic,
      spontaneous, and disordered. The PO43- removal mostly occurred via electrostatic
      attraction between the sorbate and sorbent surfaces. Moreover, the PO43- sorption
      was reversible and could be desorbed at varying rates in both neutral and
      alkaline environments. The good desorption capacity has practical benefits for
      potential regeneration and re-use of the saturated particles in wastewater
      treatment systems.

PMID- 29843065
TI  - The poisoning effect of PbO and PbCl2 on CeO2-TiO2 catalyst for selective
      catalytic reduction of NO with NH3.
AB  - The poisoning effect of PbO and PbCl2 on CeO2-TiO2 catalyst for selective
      catalytic reduction of NO with NH3 was investigated and compared. Both Pb species
      could deactivate the CeO2-TiO2 catalyst and PbO had a stronger poisoning effect
      than PbCl2. From the characterization results of BET, XRD, XPS, NH3-TPD and H2
      TPR, it was concluded that the more serious deactivation by PbO could be ascribed
      to smaller BET surface area, fewer surface Ce3+ and chemisorbed oxygen, stronger
      interaction between PbO and CeO2-TiO2 catalyst, lower redox properties and
      surface acidity. The in situ DRIFT study results revealed that the NH3-SCR
      reaction over CeO2-TiO2 catalyst was governed by both E-R and L-H mechanisms,
      which wasn't changed over the Pb-poisoned samples. The greater loss of Bronsted
      acid sites attributed to fewer surface Ce3+ and more serious inhibition of NO
      oxidation to NO2 due to fewer surface chemisorbed oxygen were two key factors
      responsible for more serious deactivation by PbO. Furthermore, the presence of Pb
      species inhibited the NH3 adsorption on the Lewis acid sites, aggravating the
      deactivation of CeO2-TiO2 catalyst.

PMID- 29843064
TI  - Synthesis of zinc ferrite/silver iodide composite with enhanced photocatalytic
      antibacterial and pollutant degradation ability.
AB  - ZnFe2O4/AgI composites were first prepared successfully with a hydrothermal
      method, and ZnFe2O4 nanoparticles were uniformly decorated on the surface of AgI
      particles. The photocatalytic activities of the obtained ZnFe2O4/AgI composites
      were investigated by the degradation of organic pollutants and the inactivation
      of bacteria under visible light irradiation. The results showed that the
      introduction of ZnFe2O4 greatly enhanced the light harvesting ability and
      improved the separation efficiency of the photogenerated charge carriers, which
      contributed to the enhanced generation of reactive species and thus promoted the
      photocatalytic performance. The 5% ZnFe2O4/AgI composite exhibited the optimal
      photocatalytic disinfection of E. coli (100% removal efficiency in 80 min) as
      well as the photocatalytic degradation of rhodamine B (RhB) (98.5% removal rate
      in 40 min). Furthermore, four consecutive cycles also demonstrated the stable
      photocatalytic activity of the as-prepared ZnFe2O4/AgI composites. In addition,
      H2O2 was identified as the predominant active species in the photocatalytic
      inactivation of bacteria. This study indicated that ZnFe2O4/AgI composites are a
      promising candidate for the treatment of wastewater.

PMID- 29843066
TI  - Fabrication of SiO2 wrapped polystyrene microcapsules by Pickering polymerization
      for self-lubricating coatings.
AB  - The facile and efficient encapsulation of a lubricant oil in SiO2 wrapped
      polystyrene microcapsules is accomplished using a Pickering polymerization
      technique. Triton X-100-IPTS fumed SiO2 nanoparticles are used as emulsifiers for
      the formation of O/W Pickering emulsions and the stability factor of the
      Pickering emulsions was investigated. The as-obtained microcapsules are
      characterized by scanning electron microscope, thermogravimetric analysis,
      Fourier transform infrared spectra and dynamic laser scattering. These results
      suggest that the microcapsules display a spherical shape with a core content of
      ~38.3%, an average diameter of 3.3 MUm, a shell thickness is ~900 nm and
      outstanding thermal stability for lubricant oil with a decomposition temperature
      of 250  degrees C. Moreover, the microcapsules are embedded into an epoxy resin
      for self-lubricating coatings. On the basis of frictional coefficient
      measurements and wear testing, the self-lubricating microcapsules-incorporated
      epoxy coatings on an aluminum plate indicate the excellent dispersibility of the
      microcapsules in coatings and the favorable antifriction effects.

PMID- 29843067
TI  - Micellar HPLC-UV method for the simultaneous determination of levodopa, carbidopa
      and entacapone in pharmaceuticals and human plasma.
AB  - A method based on micellar liquid chromatography to quantify levodopa, carbidopa
      and entacapone in plasma is reported. The sample pretreatment was a simple
      dilution in a pure micellar solution then filtration and direct injection,
      without requiring extraction or purification steps. The three drugs were resolved
      from the matrix in 7 min, using an aqueous solution of 0.1 M sodium dodecyl
      sulphate-10% n-propanol-0.3 tiethylamine, adjusted at pH 2.8 with 0.02 M
      orthophosphoric acid as mobile phase, running under isocratic mode at 1.0 mL/ min
      through VP-ODS column. The detection was done by UV (ultraviolet) absorbance at
      225 nm. The method was successfully validated by the International Conference
      Harmonization guidelines in terms of: selectivity, linearity (r2 > 0.998) over
      the concentration ranges of 0.025-1.2, 0.05-1.0 and 0.3-2.0 MUg mL-1 with limits
      of detection of 0.01, 6.16 * 10-3 and 0.02 MUg mL-1 and limits of quantification
      of 0.03, 0.02 and 0.07 MUg mL-1 for levodopa, carbidopa and entacapone,
      respectively. The proposed method was applied successfully for quantification of
      the studied drugs in their different dosage forms. Moreover, the method was
      further extensive to the quantification of the studied drugs in spiked human
      plasma and was successfully validated by the guidelines of the European Medicines
      Agency. The proposed procedures were successfully evaluated to determine the
      studied drugs in real human plasma. The procedure was found reliable, practical,
      cost-effective, available, short period, easy-to-handle, low-cost, environmental
      friendly, secure, useful for the analysis of numerous samples per day. Lastly,
      the method was performed to the analysis of incurred, using quality control
      samples in the same analytical run, with adequate results. Therefore, it can be
      implementable for custom analysis in clinical laboratories.

PMID- 29843068
TI  - When should foetal pH measurements be performed after a prolonged deceleration?
      An experimental study in a fetal sheep model.
AB  - OBJECTIVE: The aim of fetal heart rate monitoring during labour is to identify
      and prevent foetal distress, but its evaluation is not perfect. Fetal scalp blood
      sampling for pH measurement is one of the second-line methods of monitoring when
      fetal heart rate is classified as suspicious. This study aims to determine when
      pH testing should be performed after a prolonged deceleration. STUDY DESIGN: This
      was an experimental study in a fetal sheep model. A partial umbilical cord
      occlusion was performed for seven minutes followed by a recuperation period of 30
      min. Hemodynamic parameters (heart rate, mean blood pressure and intra-amniotic
      pressure) and blood gases were recorded before occlusion (T0), during occlusion
      (T4), just after the end of occlusion (T7), and then 10, 20 and 30 min after
      occlusion (T17, T27 and T37 respectively). RESULTS: Ten experiments were carried
      out. During partial cord occlusion, the fetal pH decreased significantly to
      acidosis. After a prolonged deceleration with fetal acidosis, the pH recovered to
      a normal value, defined by a pH greater than or equal to 7.25, after 20 min of
      recuperation. CONCLUSION: After a prolonged deceleration, fetal pH normalizes
      between 20 and 30 min thereafter. Thus, if a foetal blood sample is indicated,
      this delay must be respected in order to avoid inducing an unnecessary
      intervention decision.

PMID- 29843069
TI  - Evaluation of cMET aberration by immunohistochemistry and fluorescence in situ
      hybridization (FISH) in triple negative breast cancers.
AB  - PURPOSE: To evaluate the incidence of cMET proto-oncogene aberration in a cohort
      of triple negative breast cancers using immunohistochemistry and fluorescence in
      situ hybridization (FISH) methods and correlated with patient outcome. PATIENTS
      AND METHODS: One hundred and six female patients with diagnosis of triple
      negative invasive breast carcinoma at The University of Texas-M D Anderson Cancer
      Center from 1983 to 2009 were included in the study. Expression of cMET was
      assessed by IHC using rabbit monoclonal anti-total cMET antibody (SP44 from
      Ventana). Staining intensity was scored on a scale of 0, 1+, 2+ and 3+. cMET
      overexpression was defined as at least moderate membranous/cytoplasmic staining
      in >=50% of tumor cells (score >= 2+). FISH analysis was performed using MET
      (7q31) specific probe (BAC clone RP11-95i20, Abbott Molecular Inc.) and the
      centromere probe (CEP7/D7Z1, Abbott Molecular Inc.) as internal control. cMET
      amplification was defined as gene copy numbers >=4 per cell or cMET/CEP7 ratio >=
      2. cMET status was tested for correlation using Fisher's exact test with other
      clinicopathological parameters. The Kaplan-Meier product limit method was used to
      estimate the survival outcomes. Cox proportional hazards models were fit to
      determine the association of cMET status by IHC, or by FISH, or by copy number
      with survival outcomes after adjustment for other patient and disease
      characteristics. RESULTS: Medium follow up is 69.4 months (range 9-317 months).
      cMET was successfully evaluated by both IHC and FISH methods in ninety-six
      patients. There were 13 patients whose tumors overexpressed cMET was by IHC. Two
      patients had cMET amplification by FISH using definitive of cMET/CEP7 ratio of
      >=2 and four patients had cMET copy number >4. Only one patient showed cMET/CEP7
      ratio of 2.53 and one was positive for cMET overexpression by IHC. No significant
      association between cMET overexpression by IHC and by FISH using cut-off of with
      either cMET/CEP7 ratio of >=2 or cMET copy number of >4 (P = 1.0). There was no
      significant correlation between the cMET overexpression and other
      clinicopathological characteristics, such as patient demographics, tumor grade,
      stage, or chemotherapy treatment history. cMET overexpression and gene
      amplification did not correlate with the prognosis of TNBC regarding OS or DFS.
      CONCLUSION: MET amplification is a rare incidence in TNBCs. cMET overexpression
      is infrequent in TNBCs and may not be driven by gene amplification. Neither have
      significant prognostic value nor do they correlate with other clinicopathological
      characteristics in this TNBC cohort.

PMID- 29843070
TI  - Influence of nicotine on orthodontic tooth movement: A systematic review of
      experimental studies in rats.
AB  - OBJECTIVE: The objective of this systematic review was to assess the impact of
      nicotine administration on orthodontic tooth movement (OTM). METHODS: A
      systematic search was conducted in PubMed, Scopus, EMBASE, MEDLINE (OVID) and Web
      of Knowledge databases and the Preferred Reporting Items for Systematic Reviews
      and Meta-Analyses (PRISMA) guidelines were followed. Studies evaluating the
      influence of nicotine on OTM, and with the presence of a control group (OTM
      without nicotine administration), were included. Quality assessment of the
      selected studies was performed following the Animal Research Reporting in Vivo
      Experiment (ARRIVE) guidelines. RESULTS: Six of the initially identified 108
      articles fulfilled the inclusion criteria and were selected. All included studies
      were performed in male rats, which underwent OTM with or without nicotine
      administration. Since there was a variation among the included studies regarding
      nicotine dosage and the duration and magnitude of force application during OTM
      only a qualitative analysis could be performed. The studies reported that
      nicotine administration accelerated OTM by inducing alveolar bone resorption
      around the moving teeth. It was also found that nicotine increased root
      resorption during experimental OTM. More standardized animal research or clinical
      studies are warranted to further evaluate the impact of nicotine on OTM.
      CONCLUSIONS: On an experimental level, nicotine exposure in rats jeopardizes OTM
      by increasing alveolar bone loss and root resorption. From a clinical
      perspective, further studies are needed to assess the impact of habitual use of
      tobacco products on OTM.

PMID- 29843071
TI  - Prevalence of early neurological deterioration after I.V - thrombolysis in acute
      ischaemic stroke patients - A hospital-based cohort study.
AB  - OBJECTIVES: Early Neurological Deterioration (END) occur in up to 25% of patients
      with ischaemic stroke receiving stroke-unit-care and in 11-13.8% of patients
      treated with iv-tissue-Plasmniogen-Activator (iv-tPA). The aim of the study was
      to establish and compare the prevalence of END and symptomatic Intracranial
      Hemorrhage (sICH) in a prospectively designed registry of consecutive patients
      treated with iv-tPA to a historic cohort of iv-tPA eligible patients whom were
      hospitalized prior to implementation of iv-tPA-treatment but receiving otherwise
      comparable acute stroke care. PATIENTS AND METHODS: Single center registry from a
      public Danish stroke-unit. Three-hundred-sixty-one unselected consecutive iv-tPA
      treated patients admitted within 4.5 h from symptom-onset with symptoms of acute
      stroke and >17 years of age. The iv-tPA-treated cohort was compared to a pre-tPA
      cohort of 246 iv-tPA-eligible patients who were admitted to the same stroke
      center from 1998 to 2001. Acute stroke care apart from iv-tPA was comparable.
      Outcome measures was assessed on admission and at 24 h; END as any increase in
      National Institute of Health Stroke Scale (NIHSS) and symptomatic Intracranial
      Hemorrhage (sICH) with use of CT-head-scan. RESULTS: END was observed in 27
      (7.5%) of the 361 patients in the tPA-cohort and 43 (17.5%) of 246 in the pre-tPA
      cohort, p < 0.0001. Any ICH was detected in 23 (6.4%) and sICH in 3 (0.8%) of the
      iv-tPA-treated patients. CONCLUSION: END is significantly less frequent in acute
      stroke patients treated with iv-tPA. Deterioration due to ICH was rare and of
      limited severity in this population. END though remains a significant
      complication after stroke why more detailed knowledge on the various causes of
      END is needed to further improve patient outcome.

PMID- 29843072
TI  - Variability and bias between magnetoencephalography systems in non-invasive
      localization of the primary somatosensory cortex.
AB  - OBJECTIVES: Magnetoencephalography (MEG) provides functional neuroimaging data
      for pre-surgical planning in patients with epilepsy or brain tumour. For mapping
      the primary somatosensory cortex (S1), MEG data are acquired while a patient
      undergoes median nerve stimulation (MNS) to localize components of the
      somatosensory evoked field (SEF). In clinical settings, only one MEG imaging
      session is usually possible due to limited resources. As such, it is important to
      have an a priori estimate of the expected variability in localization.
      Variability in S1 localization between mapping sessions using the same MEG system
      has been previously measured as 8 mm. There are different types of MEG systems
      available with varied hardware and software, and it is not known how using a
      different MEG system will impact on S1 localization. PATIENTS AND METHODS: In our
      study, healthy participants underwent the MNS procedure with two different MEG
      systems (Vector View and CTF). We compared the location, amplitude and latency of
      SEF components between data from each system to quantify variability and bias
      between MEG systems. RESULTS: We found 8-11 mm variability in S1 localization
      between the two MEG systems, and no evidence for a systematic bias in location,
      amplitude or latency between the two systems. CONCLUSION: These findings suggest
      that S1 localization is not biased by the type of MEG system used, and that
      differences between the two systems are not a major contributor to variability in
      localization.

PMID- 29843073
TI  - Breast and cervical cancer incidence and mortality trends in Russia 1980-2013.
AB  - BACKGROUND: Breast and cervical cancer are among the leading causes of
      preventable cancer deaths in women in Russia. The aim of this study is to analyze
      changes in breast and cervical cancer incidence and mortality trends using data
      from the Russian State Cancer Registry. METHODS: The age-standardized rates of
      cervical cancer incidence (1993-2013) and mortality (1980-2013) were analyzed
      using piecewise linear regression. Age-period-cohort models were used to estimate
      the temporal effects and provide future predictions. RESULTS: Breast and cervical
      cancer incidence rates uniformly increased over two decades from 33.0 to 47.0 per
      100,000 and from 10.6 to 14.2 per 100,000, respectively. Breast cancer mortality
      rates however declined from 17.6 to 15.7 in 2013, while cervical cancer mortality
      increased steadily from 5.6 to 6.7. Breakpoints in the risk occurred in cohorts
      born 1937-1953, indicating a recent generational decrease in breast cancer
      mortality, but a concomitant increase in cervical cancer. Cervical cancer has
      already surpassed breast cancer in terms of years of life lost (YLL) (23.4 per
      death vs 18.5 in 2009-2013), while future projections suggest that the annual YLL
      could reach 1.2 million for cervical cancer and (decline to) 1.8 million for
      breast cancer by the year 2030. CONCLUSION: The temporal patterns of breast
      cancer incidence and mortality in Russia are in line with other countries in
      Europe, although cervical cancer rates and the risk of occurrence in recent
      generations is rapidly increasing; these trends underscore the need to place
      immediate priority in national cervical vaccination and screening programs.

PMID- 29843075
TI  - The use of continuous Erector Spinae Plane blockade for analgesia following major
      abdominal surgery in a one-day old neonate.

PMID- 29843074
TI  - Changing sex risk behaviors, gender norms, and relationship dynamics among
      couples in Cape Town, South Africa: Efficacy of an intervention on the dyad.
AB  - RATIONALE: South Africa continues to experience new HIV infections, with the
      highest risk among Black Africans living in poor communities. Most HIV prevention
      interventions target women or men separately and only a small number target
      couples jointly. OBJECTIVE: This study examines varying strategies to engage
      women and men around HIV prevention and improved couple interactions. METHODS:
      The study comprises three arms: (1) a couple-based intervention delivered to
      women and men jointly; (2) women and men both offered a gender-focused
      intervention that is delivered to them separately; and (3) an intervention
      offered to women only and their male partners receive standard HIV testing and
      counseling (comparison arm). Between June 2010 and April 2012, men were
      identified in and around drinking establishments in a large disadvantaged
      community in Cape Town and asked to participate in the study if they drink
      regularly, had recent unprotected sex with their partner, and have a female
      partner who was willing to participate in the study. RESULTS: A total of 299
      couples completed the baseline assessment and 276 were included in the analysis
      of sexual risk, partner communication, conflict resolution, and gender norm
      outcomes at baseline and six-month follow-up. Couples that participated in the
      couple-level intervention and couples where both partners received the
      intervention separately had better couple-level gender norms than couples in the
      comparison arm (women only receive intervention). Further, couples in the couple
      level intervention and the both partners exposed separately arms were more likely
      to have the man only report consistent condom use than neither partner report
      consistent condom use than couples in the comparison arm. CONCLUSION: Community
      based HIV prevention intervention programs need to consider strategies to engage
      women and men and, if feasible, reach both partners jointly. Couple-level
      interventions are promising to improve gender norms and subsequently improve
      health outcomes, including reduced HIV risk among women, men, and couples.

PMID- 29843076
TI  - How are the beliefs about mental health first aid among adults?

PMID- 29843077
TI  - Construction of population-specific Indian MRI brain template: Morphometric
      comparison with Chinese and Caucasian templates.
AB  - OBJECTIVE: Spatial normalization of brain MR images is highly dependent on the
      choice of target brain template. Morphological differences caused by factors like
      genetic and environmental exposures, generates a necessity to construct
      population specific brain templates. Brain image analysis performed using brain
      templates from Caucasian population may not be appropriate for non-Caucasian
      population. In this study, our objective was to construct an Indian brain
      template from a large population (N = 157 subjects) and compare the morphometric
      parameters of this template with that of Chinese-56 and MNI-152 templates. In
      addition, using an independent MRI data of 15 Indian subjects, we also evaluated
      the potential registration accuracy differences using these three templates.
      METHODS: Indian brain template was constructed using iterative routines as per
      established procedures. We compared our Indian template with standard MNI-152
      template and Chinese template by measuring global brain features. We also
      examined accuracy of registration by aligning 15 new Indian brains to Indian,
      Chinese and MNI templates. Furthermore, we supported our measurement protocol
      with inter-rater and intra-rater reliability analysis. RESULTS: Our results
      showed that there were significant differences in global brain features of Indian
      template in comparison with Chinese and MNI brain templates. The results of
      registration accuracy analysis revealed that fewer deformations are required when
      Indian brains are registered to Indian template as compared to Chinese and MNI
      templates. CONCLUSION: This study concludes that population specific Indian
      template is likely to be more appropriate for structural and functional image
      analysis of Indian population.

PMID- 29843079
TI  - Tricellular junctions: a hot corner of epithelial biology.
AB  - As the result of an intricate interplay between mechanical and biochemical cues,
      coordinated cell dynamics are at the basis of tissue development, homeostasis and
      repair. Numerous studies have addressed the interplay between these two inputs
      and their impact on cellular dynamics. These studies largely focus on bicellular
      junctions (BCJs). Recent works have illuminated that tricellular junctions
      (TCJs), the junctions where three cells contact, play important roles in
      epithelial tissues beyond their well-known structural function in preserving
      epithelial barrier integrity. Indeed, TJCs have recently been implicated in the
      regulation of collective cell migration, division orientation, cell proliferation
      and cell mechanical properties. More generally, the TCJ distribution aligns with
      the cell shape and mechanical stress orientation within the tissue, while their
      number encapsulates the packing topology. Importantly, known regulators of growth
      signalling and of cell mechanical properties are also localized at TCJs.
      Therefore, TCJs emerge as spatial sites to sense and integrate biochemical and
      mechanical inputs to guide epithelial tissue dynamics.

PMID- 29843078
TI  - Quantifying the uncertainty in model parameters using Gaussian process-based
      Markov chain Monte Carlo in cardiac electrophysiology.
AB  - Model personalization requires the estimation of patient-specific tissue
      properties in the form of model parameters from indirect and sparse measurement
      data. Moreover, a low-dimensional representation of the parameter space is
      needed, which often has a limited ability to reveal the underlying tissue
      heterogeneity. As a result, significant uncertainty can be associated with the
      estimated values of the model parameters which, if left unquantified, will lead
      to unknown variability in model outputs that will hinder their reliable clinical
      adoption. Probabilistic estimation of model parameters, however, remains an
      unresolved challenge. Direct Markov Chain Monte Carlo (MCMC) sampling of the
      posterior distribution function (pdf) of the parameters is infeasible because it
      involves repeated evaluations of the computationally expensive simulation model.
      To accelerate this inference, one popular approach is to construct a
      computationally efficient surrogate and sample from this approximation. However,
      by sampling from an approximation, efficiency is gained at the expense of
      sampling accuracy. In this paper, we address this issue by integrating surrogate
      modeling of the posterior pdf into accelerating the Metropolis-Hastings (MH)
      sampling of the exact posterior pdf. It is achieved by two main components: (1)
      construction of a Gaussian process (GP) surrogate of the exact posterior pdf by
      actively selecting training points that allow for a good global approximation
      accuracy with a focus on the regions of high posterior probability; and (2) use
      of the GP surrogate to improve the proposal distribution in MH sampling, in order
      to improve the acceptance rate. The presented framework is evaluated in its
      estimation of the local tissue excitability of a cardiac electrophysiological
      model in both synthetic data experiments and real data experiments. In addition,
      the obtained posterior distributions of model parameters are interpreted in
      relation to the factors contributing to parameter uncertainty, including
      different low-dimensional representations of the parameter space, parameter non
      identifiability, and parameter correlations.

PMID- 29843080
TI  - Thermal inactivation of human norovirus surrogates in oyster homogenate.
AB  - Human norovirus (HNV) is the most frequent causative agent of foodborne diseases
      in the US. Raw and undercooked oysters are commonly associated with outbreaks
      caused by HNV. Many guidelines recommend that shucked oysters be boiled for at
      least 3 min, but it is not clear this thermal treatment can inactivate HNV. The
      objective of this research was to evaluate whether this recommendation was
      sufficient to inactivate two HNV surrogates, murine norovirus (MNV-1) and Tulane
      virus (TV) in oyster homogenate as well as to determine their thermal
      inactivation kinetics. Inoculated oyster homogenate was heated in boiling water
      and circulating water bath at 49 to 67  degrees C for different time durations.
      After 3 min of boiling, both MNV-1 and TV titers decreased to below the detection
      limits. First-order model and Weibull model were used to describe thermal
      inactivation kinetics. TD = 1 values from Weibull mode are used as an analog to D
      values in first-order model. The D values of MNV-1 and TD = 1 values ranged from
      28.17 to 0.88 min and 26.64 to 0.78 min at 49 to 67  degrees C, respectively. The
      D values of TV and TD = 1 values ranged from 18.18 to 1.56 min and 19.35 to 1.56
      min at 49 to 63  degrees C, respectively. The kinetics demonstrated that at
      temperatures > 58  degrees C, TV was much more heat sensitive than MNV-1. As the
      temperature increased over 58  degrees C, the inactivation of both viruses
      occurred at a faster rate. Boiling treatment for 3 min as recommended by FDA for
      cooking shucked oysters, inactivated MNV-1 and TV in oyster homogenate below
      detection limit. One minute heating of TV at 63  degrees C or MNV-1 at 67 
      degrees C in contaminated oyster homogenate reduced the viral titers below the
      detection limits. Our research identified effective combinations of time and
      temperature to inactivate two HNV surrogate viruses, and thus provides insights
      on thermal processing to reduce the risk of foodborne viral illness outbreaks
      associated with consumption of oysters.

PMID- 29843081
TI  - The expression of kisspeptin and its receptor in the domestic cat ovary and
      uterus in different stages of the ovarian cycle.
AB  - Kisspeptin is well known for its indispensable role in the regulation of
      reproduction, mainly through controlling the release of GnRH at the hypothalamic
      level. Recent studies have shown that kisspeptin and the kisspeptin receptor are
      expressed in the ovary and uterus, indicating an additional local function in
      reproduction at the extra-hypothalamic level. In this study, we aimed: (1) to
      investigate the localization pattern of kisspeptin and its receptor in the
      domestic cat ovary and uterus throughout the ovarian cycle using
      immunohistochemistry; and (2) to compare the relative expression of ovarian Kiss1
      mRNA levels at different ovarian stages with qPCR analysis. Ovaries and uteri
      were collected and classified into three ovarian stages (inactive, follicular and
      luteal stages (n = 7 in each stage)) according to the ovarian morphology, vaginal
      cytology and serum progesterone. Kisspeptin immunoreactivity (Kp-IR) and
      kisspeptin receptor immunoreactivity (KpR-IR) were present in the ovaries and
      uteri at all ovarian stages, with no notable differences in the localization
      patterns between the ovarian stages. In the ovary, Kp-IR and KpR-IR were present
      in various ovarian compartments, including the follicles at all classes and the
      corpus luteum (CL). In the follicles, Kp-IR and KpR-IR were present in the
      oocytes, granulosa cells and theca cells. Kp-IR was also detected in the
      follicular fluid of antral follicles. In CL, a strong intensity of Kp-IR was
      present in the periphery CL of development/maintenance, with a relatively fainter
      intensity in the central CL. By contrast, KpR-IR was present in both peripheral
      and central CL at the same intensity. In the uterus, Kp-IR and KpR-IR were
      present in the uterine glands, myometrium and perimetrium. The relative ovarian
      Kiss1 mRNA level was higher in the follicular stage than in the luteal stage (P <
      0.05). We concluded that kisspeptin and its receptor are present in the cat ovary
      and uterus, suggesting possible local functions of kisspeptin at the extra
      hypothalamic level, such as folliculogenesis, oocyte survival and uterine
      adenogenesis.

PMID- 29843082
TI  - Tri-dimensional pattern analysis of foodstuff bitemarks - A pilot study of
      tomographic database.
AB  - The analysis of bitemarks has been mostly done through analogical methods. The
      advent of current technologies brings new and more reliable tools for analyzing
      evidence. Bitemarks can now be turned into more consistent evidence by using a
      digital tridimensional (3D) analysis. The aim of this study is to propose a
      reliable, accurate and monitorized approach of 3D bitemark analysis. 12 cranium
      Cone Beam Computed Tomographic (CBCT) files were randomly selected from a
      clinical database (Coimbra Hospital and University Center/Faculty of Medicine of
      the University of Coimbra). The individuals were recalled to bite an apple
      (golden delicious 65/80) immediately subjected to a CBCT scan. The 3D rendering
      of every bitemark was compared with the 3D upper dental arches obtained from the
      CBCT cranium scans of the simulated suspects. The research team was composed by 5
      elements. The matching process consists of corresponding landmark points, in both
      the bitemark and the suspects' dentition (upper dental arch). 144 comparisons
      were obtained. The Kappa statistics analysis was performed. Cohen's Kappa values
      were obtained between 0,690 and 0,910. Fleiss Kappa obtained a value of 0,767.
      The Friedman's test was performed and the normality assumption was not verified
      (p>0,05). A non-destructive protocol of bitemark study by 3D analysis of
      tomographic volumes was presented. The statistic analysis supports its accuracy
      and reliability. This experimental study opens doors to a future where bitemark
      analysis could be done through software that searches for matching dentitions in
      a CBCT database.

PMID- 29843083
TI  - SIRT7 regulates the TGF-beta1-induced proliferation and migration of mouse airway
      smooth muscle cells by modulating the expression of TGF-beta receptor I.
AB  - Accumulating evidence shows that sirtuin 7 (SIRT7), a key mediator of many
      cellular activities, plays an important role in the pathogenesis of various
      diseases; however, little is known about the role of SIRT7 in asthma, which is
      characterized by airway remodeling. This study investigated the potential role of
      SIRT7 in regulating the proliferation and migration of airway smooth muscle (ASM)
      cells, which are critical events during airway remodeling in asthmatic
      conditions. The results demonstrated that SIRT7 expression was significantly
      upregulated in ASM cells treated with transforming growth factor-beta 1 (TGF
      beta1). Knockdown of SIRT7 inhibited the proliferation, promoted the apoptosis,
      and suppressed the migration of TGF-beta1-treated ASM cells, while overexpression
      of SIRT7 had the opposite effect. Moreover, knockdown of SIRT7 inhibited protein
      expression of the TGF-beta receptor I (TbetaRI), whilst overexpression of SIRT7
      promoted the expression of TbetaRI. Importantly, knockdown of TbetaRI partially
      reversed the stimulatory effect of SIRT7 overexpression on the TGF-beta1-induced
      proliferation and migration of ASM cells. Taken together, these results
      demonstrate that SIRT7 is involved in regulating TGF-beta1-induced ASM cell
      proliferation and migration by regulating the expression of TbetaRI, thus
      indicating an important role of SIRT7 during airway remodeling in asthma.

PMID- 29843084
TI  - Chronic hyponatremia - Why care? A case report.

PMID- 29843085
TI  - Accurate source imaging based on high resolution scalp electroencephalography and
      individualized finite difference head models in epilepsy pre-surgical workup.
AB  - PURPOSE: High-density electroencephalographic source imaging (HD-ESI) has emerged
      as a useful tool for pre-surgical epilepsy workup. However, it is not routinely
      used in clinical evaluations due to several factors, one of which is the
      challenge associated with creating anatomically accurate head models. Reasonable
      solutions now exist and the present study aims to evaluate the use of these
      highly resolved individual head models in pre-surgical epilepsy evaluation.
      METHODS: Nine patients with intractable epilepsy who were candidates for
      resective epilepsy surgeries participated in the study. For each patient, 256
      channel electroencephalography data were acquired along with individual
      structural MRI data that was used to construct individual finite difference
      models (iFDM). Accuracy of HD-ESI based on iFDM (HD-ESI-iFDM) was evaluated using
      multiple criteria, including concordance with intracranial electroencephalography
      (icEEG) and location of surgical resection. Performance of HD-ESI-iFDM was also
      compared against MRI and positron emission tomography (PET) results. RESULTS: In
      all but one patient resective surgeries resulted in seizure-free outcome. Source
      locations derived from HD-ESI-iFDM demonstrated concordance with surgical
      resection and with icEEG data, when available. The HD-ESI-iFDM also contributed
      to the planning of intracranial electrodes implantation. Compared to MRI or PET,
      HD-ESI-iFDM provided more accurate localization of the epileptogenic zone.
      CONCLUSION: When acquired with high-density sensor arrays and source imaging is
      performed with anatomically accurate head models, electroencephalography can
      contribute meaningfully to epilepsy pre-surgical workup for localization of the
      epileptogenic zone. Now that both high-density electroencephalography and
      individualized FDM models can be routinely obtained, it can be incorporated as
      part of clinical practice.

PMID- 29843086
TI  - The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model
      of myocardial infarction.
AB  - INTRODUCTION: Rivaroxaban selectively inhibits factor Xa (FXa), which plays a
      central role in blood coagulation. In addition, FXa activates protease-activated
      receptor-2 (PAR-2). We have shown that PAR-2-/- mice exhibit less cardiac
      dysfunction after cardiac injury. MATERIAL AND METHODS: Wild-type (WT) and PAR-2
      /- mice were subjected to left anterior descending artery (LAD) ligation to
      induce cardiac injury and heart failure. Mice received either placebo or
      rivaroxaban chow either starting at the time of surgery or 3 days after surgery
      and continued up to 28 days. Cardiac function was measured by echocardiography
      pre-surgery and 3, 7 and 28 days after LAD ligation. We also measured
      anticoagulation, intravascular thrombi, infarct size, cardiac hypertrophy and
      inflammation at various times. RESULTS: Rivaroxaban increased the prothrombin
      time and inhibited the formation of intravascular thrombi in mice subjected to
      LAD ligation. WT mice receiving rivaroxaban immediately after surgery had similar
      infarct sizes at day 1 as controls but exhibited significantly less impairment of
      cardiac function at day 3 and beyond compared to the placebo group. Rivaroxaban
      also inhibited the expansion of the infarct at day 28. Rivaroxaban did not
      significantly affect the expression of inflammatory mediators or a neutrophil
      marker at day 2 after LAD ligation. Delaying the start of rivaroxaban
      administration until 3 days after surgery failed to preserve cardiac function. In
      addition, rivaroxaban did not reduce cardiac dysfunction in PAR-2-/- mice.
      CONCLUSIONS: Early administration of rivaroxaban preserves cardiac function in
      mice after LAD ligation.

PMID- 29843087
TI  - Persistence to direct oral anticoagulants for acute venous thromboembolism.
AB  - BACKGROUND: Currently, direct oral anticoagulants (DOACs) are the treatment of
      choice for venous thromboembolism (VTE) in the Netherlands. The main advantages
      of DOACs over vitamin K antagonists (VKAs) are that they are safer than VKA and
      that neither monitoring nor dose titrations are needed. A main drawback is a
      potential risk of lower drug persistence, as compared with VKA treatment, which
      is strictly controlled by anticoagulation clinics in the Netherlands. OBJECTIVES:
      The primary aim of this study was to audit the persistence to DOAC treatment for
      acute VTE during the first 2 months in daily clinical practice. METHODS:
      Dispensing data from the Dutch Foundation of Pharmaceutical Statistics were used
      to monitor persistence to DOAC for treatment of VTE from 1 January 2012-1 April
      2016. Non-persistence was defined as the cumulative incidence of patients who
      completely stopped DOAC or VKA treatment. In addition, we estimated the
      persistence to VKA treatment for VTE in data from the Anticoagulation Clinic
      Leiden. RESULTS: 1834 patients were selected as DOAC users for the indication
      VTE. The 2-month cumulative incidence of completely stopping DOAC was 20% (95%
      confidence interval [CI] 18-24). In the population of 4910 VKA users, 9.1% (95%CI
      8.3-9.9) stopped prematurely with VKA. CONCLUSION: The stopping rate of 20% we
      found is in line with other cardiovascular treatments. Further research into the
      reasons and consequences of prematurely stopping DOAC treatment for acute VTE is
      urgently needed.

PMID- 29843088
TI  - Optimization of rotational speed and hydraulic retention time of a rotational
      sponge reactor for sewage treatment.
AB  - A rotational sponge (RS) reactor was proposed as an alternative sewage treatment
      process. Prior to the application of an RS reactor for sewage treatment, this
      study evaluated reactor performance with regard to organic removal,
      nitrification, and nitrogen removal and sought to optimize the rotational speed
      and hydraulic retention time (HRT) of the system. RS reactor obtained highest COD
      removal, nitrification, and nitrogen removal efficiencies of 91%, 97%, and 65%,
      respectively. For the optimization, response surface methodology (RSM) was
      employed and optimum conditions of rotational speed and HRT were 18 rounds per
      hour and 4.8 h, respectively. COD removal, nitrification, and nitrogen removal
      efficiencies at the optimum conditions were 85%, 85%, and 65%, respectively.
      Corresponding removal rates at optimum conditions were 1.6 kg-COD m-3d-1, 0.3 kg
      NH4+-N m-3d-1, and 0.12 kg-N m-3d-1. Microbial community analysis revealed an
      abundance of nitrifying and denitrifying bacteria in the reactor, which
      contributed to nitrification and nitrogen removal.

PMID- 29843089
TI  - Photocatalytic-oxidation and photo-persulfate-oxidation of sulfadiazine in a
      laboratory-scale reactor: Analysis of catalyst support, oxidant dosage, removal
      rate and degradation pathway.
AB  - The extent of sulfadiazine (SDZ) removal via photo-degradation (UV-C),
      photocatalysis with TiO2 (UV-C/TiO2) and photo-persulfate-oxidation (UV-C/PS) was
      investigated in a batch reactor under different UV-C power levels (i.e. 14, 28,
      42 and 56 W). Moreover, effects of suspended/immobilized catalyst, i.e. TiO2
      slurry/TiO2 supported on granular activated carbon (GAC-TiO2), on SDZ removal and
      corresponding SDZ degradation kinetics under different catalyst loading (1-6 g/L)
      were explored. Around 41.7% SDZ removal was observed after 120 min in UV-C system
      at the highest power level, i.e. 56 W. On the other hand, photocatalysis with
      TiO2 and GAC-TiO2 has shown better SDZ removal than photo-degradation. In UV
      C/TiO2 (4 g/L and 28 W) and UV-C/GAC-TiO2 (5 g/L and 28 W) systems, SDZ removals
      were 91.8% after 120 min and 100% after 60 min, respectively; however, TOC
      analysis has revealed that 45.4% and 60.8% SDZ was mineralized in these systems,
      respectively. In UV-C/PS system, near complete degradation of SDZ (99.8%) was
      observed within 10 min under 50 mg/L of PS and 28 W UV illumination. On the other
      hand, complete SDZ removal was observed in PS alone system at a dosage of 1000
      mg/L but the formation of SO42- was found to be a drawback. In photolysis and
      photocatalysis systems, SDZ removal followed pseudo-first-order kinetics whereas
      the kinetics followed pseudo-second-order in UV-C/PS system. The comparison of
      electrical energy consumed (EEO) in different systems revealed that UV-C/GAC-TiO2
      and UV-C/PS system were energy efficient compared with other systems. The LC-MS
      analysis has confirmed the cleavage of C-N bonds in the pyrimidine ring followed
      by S-N bonds in the sulfonyl group, which was found to be the major degradation
      pathway of SDZ.

PMID- 29843090
TI  - Adaptive governance good practice: Show me the evidence!
AB  - Adaptive governance has emerged in the last decade as an intriguing avenue of
      theory and practice for the holistic management of complex environmental
      problems. Research on adaptive governance has flourished since the field's
      inception, probing the process and mechanisms underpinning the new approach while
      offering various justifications and prescriptions for empirical use.
      Nevertheless, recent reviews of adaptive governance reveal some important
      conceptual and practical gaps in the field, particularly concerning challenges in
      its application to real-world cases. In this paper, we respond directly to the
      empirical challenge of adaptive governance, specifically asking: which methods
      contribute to the implementation of successful adaptive governance process and
      outcomes in practice and across cases and contexts? We adopt a systematic
      literature review methodology which considers the current body of empirical
      literature on adaptive governance of social-ecological systems in order to assess
      and analyse the methods affecting successful adaptive governance practice across
      the range of existing cases. We find that methods contributing to adaptive
      governance in practice resemble the design recommendations outlined in previous
      adaptive governance scholarship, including meaningful collaboration across actors
      and scales; effective coordination between stakeholders and levels; building
      social capital; community empowerment and engagement; capacity development;
      linking knowledge and decision-making through data collection and monitoring;
      promoting leadership capacity; and exploiting or creating governance
      opportunities. However, we critically contextualise these methods by analysing
      and summarising their patterns-in-use, drawing examples from the cases to explore
      the specific ways they were successfully or unsuccessfully applied to governance
      issues on-the-ground. Our results indicate some important underlying shared
      patterns, trajectories, and lessons learned for evidence-based adaptive
      governance good practice within and across diverse sectors, issues, and contexts.

PMID- 29843091
TI  - Sustainable biodegradation of phenol by immobilized Bacillus sp. SAS19 with
      porous carbonaceous gels as carriers.
AB  - In this study, high-efficient phenol-degrading bacterium Bacillus sp. SAS19 which
      was isolated from activated sludge by resuscitation-promoting factor (Rpf)
      addition, were immobilized on porous carbonaceous gels (CGs) for phenol
      degradation. The phenol-degrading capabilities of free and immobilized Bacillus
      sp. SAS19 were evaluated under various initial phenol concentrations. The
      obtained results showed that phenol could be removed effectively by both free and
      immobilized Bacillus sp. SAS19. Furthermore, for degradation of phenol at high
      concentrations, long-term utilization and recycling were more readily achieved
      for immobilized bacteria as compared to free bacteria. Immobilized bacteria
      exhibited significant increase in phenol-degrading capabilities in the third
      cycle of recycling and reuse, which demonstrated 87.2% and 100% of phenol (1600
      mg/L) degradation efficiency at 12 and 24 h, respectively. The present study
      revealed that immobilized Bacillus sp. SAS19 can be potentially used for enhanced
      treatment of synthetic phenol-laden wastewater.

PMID- 29843092
TI  - Novel hybrid linear stochastic with non-linear extreme learning machine methods
      for forecasting monthly rainfall a tropical climate.
AB  - A novel hybrid approach is presented that can more accurately predict monthly
      rainfall in a tropical climate by integrating a linear stochastic model with a
      powerful non-linear extreme learning machine method. This new hybrid method was
      then evaluated by considering four general scenarios. In the first scenario, the
      modeling process is initiated without preprocessing input data as a base case.
      While in other three scenarios, the one-step and two-step procedures are utilized
      to make the model predictions more precise. The mentioned scenarios are based on
      a combination of stationarization techniques (i.e., differencing, seasonal and
      non-seasonal standardization and spectral analysis), and normality transforms
      (i.e., Box-Cox, John and Draper, Yeo and Johnson, Johnson, Box-Cox-Mod, log, log
      standard, and Manly). In scenario 2, which is a one-step scenario, the
      stationarization methods are employed as preprocessing approaches. In scenario 3
      and 4, different combinations of normality transform, and stationarization
      methods are considered as preprocessing techniques. In total, 61 sub-scenarios
      are evaluated resulting 11013 models (10785 linear methods, 4 nonlinear models,
      and 224 hybrid models are evaluated). The uncertainty of the linear, nonlinear
      and hybrid models are examined by Monte Carlo technique. The best preprocessing
      technique is the utilization of Johnson normality transform and seasonal
      standardization (respectively) (R2 = 0.99; RMSE = 0.6; MAE = 0.38; RMSRE = 0.1,
      MARE = 0.06, UI = 0.03 &UII = 0.05). The results of uncertainty analysis
      indicated the good performance of proposed technique (d-factor = 0.27; 95PPU =
      83.57). Moreover, the results of the proposed methodology in this study were
      compared with an evolutionary hybrid of adaptive neuro fuzzy inference system
      (ANFIS) with firefly algorithm (ANFIS-FFA) demonstrating that the new hybrid
      methods outperformed ANFIS-FFA method.

PMID- 29843093
TI  - Influence of post coating heat treatment on microstructural, mechanical and
      electrochemical corrosion behaviour of vacuum plasma sprayed reinforced
      hydroxyapatite coatings.
AB  - In the present study, reinforced hydroxyapatite (HA) coatings (HA + 10 wt% Al2O3
      and HA + 10 wt% ZrO2) were deposited on SS-316 L substrate with an intermediate
      layer (bond coat) of zirconia by vacuum plasma spray technique. The so-formed
      reinforced HA coatings were heat treated at 700  degrees C for 1 h. The influence
      of post coating heat treatment on phase composition, microstructure, mechanical
      and electrochemical corrosion properties were investigated. As-sprayed and heat
      treated coatings were characterized by x-ray diffraction, scanning electron
      microscope, surface roughness, porosity and crystallinity. Results showed that
      after post coating heat treatment, the structural integrity of HA has been
      completely re-established. Moreover, significant drop in porosity has been
      observed due to the sintering effect produced by heat treatment. Considerable
      improvement in nanohardness and shear strength was witnessed; however, the
      nanohardness of top layer was decreased after annealing due to the weak bonding
      of partially melted and un-melted particles with fully melted splats caused by
      diffusion process. As-sprayed coatings exhibited higher wear resistance compared
      to heat treated coatings. Nevertheless, post coating heat treatment effectively
      enhanced the corrosion resistance of coatings, since, the heat treatment lead to
      densification of coatings microstructure which further reduces the active sites
      for dissolution.

PMID- 29843094
TI  - Integrating MRI-based geometry, composition and fiber architecture in a finite
      element model of the human intervertebral disc.
AB  - Intervertebral disc degeneration is a common disease that is often related to
      impaired mechanical function, herniations and chronic back pain. The degenerative
      process induces alterations of the disc's shape, composition and structure that
      can be visualized in vivo using magnetic resonance imaging (MRI). Numerical tools
      such as finite element analysis (FEA) have the potential to relate MRI-based
      information to the altered mechanical behavior of the disc. However, in terms of
      geometry, composition and fiber architecture, current FE models rely on
      observations made on healthy discs and might therefore not be well suited to
      study the degeneration process. To address the issue, we propose a new, more
      realistic FE methodology based on diffusion tensor imaging (DTI). For this study,
      a human disc joint was imaged in a high-field MR scanner with proton-density
      weighted (PD) and DTI sequences. The PD image was segmented and an anatomy
      specific mesh was generated. Assuming accordance between local principal
      diffusion direction and local mean collagen fiber alignment, corresponding fiber
      angles were assigned to each element. Those element-wise fiber directions and PD
      intensities allowed the homogenized model to smoothly account for composition and
      fibrous structure of the disc. The disc's in vitro mechanical behavior was
      quantified under tension, compression, flexion, extension, lateral bending and
      rotation. The six resulting load-displacement curves could be replicated by the
      FE model, which supports our approach as a first proof of concept towards patient
      specific disc modeling.

PMID- 29843095
TI  - Adaptive critic designs for optimal control of uncertain nonlinear systems with
      unmatched interconnections.
AB  - In this paper, we develop a novel optimal control strategy for a class of
      uncertain nonlinear systems with unmatched interconnections. To begin with, we
      present a stabilizing feedback controller for the interconnected nonlinear
      systems by modifying an array of optimal control laws of auxiliary subsystems. We
      also prove that this feedback controller ensures a specified cost function to
      achieve optimality. Then, under the framework of adaptive critic designs, we use
      critic networks to solve the Hamilton-Jacobi-Bellman equations associated with
      auxiliary subsystem optimal control laws. The critic network weights are tuned
      through the gradient descent method combined with an additional stabilizing term.
      By using the newly established weight tuning rules, we no longer need the initial
      admissible control condition. In addition, we demonstrate that all signals in the
      closed-loop auxiliary subsystems are stable in the sense of uniform ultimate
      boundedness by using classic Lyapunov techniques. Finally, we provide an
      interconnected nonlinear plant to validate the present control scheme.

PMID- 29843096
TI  - High-resolution Self-Organizing Maps for advanced visualization and dimension
      reduction.
AB  - Kohonen's Self Organizing feature Map (SOM) provides an effective way to project
      high dimensional input features onto a low dimensional display space while
      preserving the topological relationships among the input features. Recent
      advances in algorithms that take advantages of modern computing hardware
      introduced the concept of high resolution SOMs (HRSOMs). This paper investigates
      the capabilities and applicability of the HRSOM as a visualization tool for
      cluster analysis and its suitabilities to serve as a pre-processor in ensemble
      learning models. The evaluation is conducted on a number of established
      benchmarks and real-world learning problems, namely, the policeman benchmark, two
      web spam detection problems, a network intrusion detection problem, and a malware
      detection problem. It is found that the visualization resulted from an HRSOM
      provides new insights concerning these learning problems. It is furthermore shown
      empirically that broad benefits from the use of HRSOMs in both clustering and
      classification problems can be expected.

PMID- 29843097
TI  - Image registration of low signal-to-noise cryo-STEM data.
AB  - Combining multiple fast image acquisitions to mitigate scan noise and drift
      artifacts has proven essential for picometer precision, quantitative analysis of
      atomic resolution scanning transmission electron microscopy (STEM) data. For very
      low signal-to-noise ratio (SNR) image stacks - frequently required for
      undistorted imaging at liquid nitrogen temperatures - image registration is
      particularly delicate, and standard approaches may either fail, or produce subtly
      specious reconstructed lattice images. We present an approach which effectively
      registers and averages image stacks which are challenging due to their low-SNR
      and propensity for unit cell misalignments. Registering all possible image pairs
      in a multi-image stack leads to significant information surplus. In combination
      with a simple physical picture of stage drift, this enables identification of
      incorrect image registrations, and determination of the optimal image shifts from
      the complete set of relative shifts. We demonstrate the effectiveness of our
      approach on experimental, cryogenic STEM datasets, highlighting subtle artifacts
      endemic to low-SNR lattice images and how they can be avoided. High-SNR average
      images with information transfer out to 0.72 A are achieved at 300 kV and with
      the sample cooled to near liquid nitrogen temperature.

PMID- 29843098
TI  - Determination of phenolic acids in extra virgin olive oil using supercritical
      fluid chromatography coupled with single quadrupole mass spectrometry.
AB  - Phenolic acids represent one third of the total phenolic compounds in extra
      virgin olive oil (EVOO) and contribute greatly to the biological and sensory
      properties of EVOO. In the present research, an analytical method based on
      supercritical fluid chromatography coupled with single quadrupole mass
      spectrometry (SFC-MS) was developed for the analysis of phenolic acids in EVOOs.
      The chromatographic and MS conditions were optimized in terms of selectivity,
      peak shape and sensitivity. Satisfactory separation of 12 phenolic acids was
      achieved within 20 min on a Platisil CN column (250 mm * 4.6 mm, 5 MUm) using 7%
      (v/v) water and 0.5% (v/v) formic acid in MeOH as mobile phase additives at the
      backpressure of 140 bar and temperature of 60  degrees C. The developed method
      was validated by evaluating the linearity, sensitivity, repeatability,
      intermediate precision and accuracy. The limits of detection (LODs) and limits of
      quantification (LOQs) of the SFC-MS method for phenolic acids ranged from 0.03 to
      5.00 MUg/mL and 0.08 to 15.0 MUg/mL, respectively. The relative standard
      deviations (RSDs) for intraday and interday precision were lower than 9.91% and
      the recoveries ranged from 80.2 to 117% and 80.9 to 118% for low-level and high
      level concentrations of standards spiked in olive oil, respectively. Compared to
      an HPLC method, the SFC method was about three times faster and provided better
      selectivity. Finally, the SFC-MS method was successfully employed for the
      quantitative analysis of phenolic acids in EVOOs. Differences in individual and
      total phenolic acid contents were observed between six varieties.

PMID- 29843099
TI  - Probing DNA damage induced by common antiviral agents using multiple analytical
      techniques.
AB  - Hepatocellular carcinoma is one of the most common malignant tumors in the world.
      Chronic hepatitis B and C infections are the most common etiologies of
      hepatocellular carcinoma worldwide. In this study, we explore the potential DNA
      damaging effect of some FDA-approved antiviral drugs which may be able to serve
      as anticancer agents for hepatocellular carcinoma, in order to better elucidate
      their mode of action. Five antiviral drugs were selected; ribavirin, sofosbuvir,
      tenofovir disoproxil fumerate, daclatasvir and ledipasvir. Several methods,
      including absorption spectroscopy, MALDI-TOF mass spectrometry and fluorimetric
      analysis using the EvaGreen (EG) intercalating dye, were used to probe the drug
      induced DNA damage. Results show that only daclatasvir and ledipasvir induced DNA
      damage. Absorption spectroscopy showed hyperchromicity in the 260-nm DNA
      absorption band of DNA samples incubated with each drug, indicating disruption of
      the double-strand structure. Mass spectra for DNA samples incubated with each of
      the two drugs showed a disappearance of the DNA molecular ion peak with a
      concomitant appearance of peaks with smaller m/z, indicating DNA strand breaks.
      EG fluorescence was observed to decrease with increasing incubation time of
      daclatasvir and ledipasvir with DNA, indicating that the EG detaches from the
      DNA, likely due to DNA damage. All of these results are consistent with DNA
      damage, proposed as oxidative damage to both nucleobase and deoxyribose moieties
      of DNA as the mode of action for these two drugs. Moreover, these results are
      dependent on the antiviral drug concentration and show that DNA regions rich in
      guanine are affected more than other regions by these two drugs. Therefore, such
      antiviral drugs may present a promising therapeutic alternative to the currently
      used anticancer agents, especially for hepatitis B and C patients with
      hepatocellular carcinoma resistant to conventional treatment approaches.

PMID- 29843100
TI  - A novel NAE/UAE dual inhibitor LP0040 blocks neddylation and ubiquitination
      leading to growth inhibition and apoptosis of cancer cells.
AB  - NEDD8 activating enzyme (NAE) plays an important role in regulating intracellular
      proteins with key parts in a broad array of cellular functions. On the basis of
      previously work, a series of 2H-chromen-2-one based NAE inhibitors were designed
      and synthesized. Through enzyme-based and cell-based assays, LP0040 was
      identified as a non-nucleoside NAE/UAE dual inhibitor. It could inhibit NAE/UAE
      activities and downregulated degradations of related substrates in AGS cells,
      promoting apoptosis in low micromole concentrations. LP0040 possessed anti
      proliferation activities with IC50 values of 0.76-3.29 MUM against multiple human
      cancer lines and had synergistic effect with bortezomib. Thus LP0040 represented
      valuable starting points for future development of NAE/UAE dual inhibitors.

PMID- 29843101
TI  - Pyridinium and indole orientation determines the mitochondrial uncoupling and
      anti-cancer efficiency of F16.
AB  - F16 is a mitochondria-targeted, broad-spectrum anticancer agent in the pre-clinic
      cancer therapy. Here we developed two fluorescent isomers of F16 (o-F16 and m
      F16) with entirely different photophysical properties, uncoupling activity, and
      cytotoxicity by merely modifying the linking orientation of pyridinium and indole
      units. Individually, o-F16 acted as a strong uncoupler to reduce the
      mitochondrial respiration efficiency, while m-F16 could hardly uncouple the
      mitochondrial respiration due to its poor proton dissociation capability. Owing
      to their intrinsic fluorescence, o-F16 and m-F16 could specifically image
      mitochondria in the green and red channel, respectively. This work could provide
      useful information for the development of uncouplers and design of mitochondrial
      targeted drugs.

PMID- 29843102
TI  - Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally
      available prodrugs against influenza viruses.
AB  - Zanamivir (ZA) and guanidino-oseltamivir carboxylic acid (GOC) are very potent
      inhibitors against influenza neuraminidase (NA). The guanidinium moiety plays an
      important role in NA binding; however, its polar cationic nature also hinders the
      use of ZA and GOC from oral administration. In this study, we investigated the
      use of ZA and GOC acylguanidine derivatives as possible orally available
      prodrugs. The acylguanidine derivatives were prepared by coupling with either n
      octanoic acid or (S)-naproxen. The lipophilic acyl substituents were verified to
      improve cell permeability, and may also improve the bioavailability of
      acylguanidine compounds. In comparison, the acylguanidines bearing linear
      octanoyl chain showed better NA inhibitory activity and higher hydrolysis rate
      than the corresponding derivatives having bulky branched naproxen moiety. Our
      molecular docking experiments revealed that the straight octanoyl chain could
      extend to the 150-cavity and 430-cavity of NA to gain extra hydrophobic
      interactions. Mice receiving the ZA octanoylguanidine derivative survived from
      influenza infection better than those treated with ZA, whereas the GOC
      octanoylguanidine derivative could be orally administrated to treat mice with
      efficacy equal to oseltamivir. Our present study demonstrates that incorporation
      of appropriate lipophilic acyl substituents to the polar guanidine group of ZA
      and GOC is a feasible approach to develop oral drugs for influenza therapy.

PMID- 29843103
TI  - Synthesis, cytotoxic evaluation and target identification of thieno[2,3
      d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position.
AB  - Two series of thieno[2,3-d]pyrimidine derivatives bearing a dithiocarbamate side
      chain at the C2 position were synthesized and evaluated for cytotoxic activity in
      human lung cancer A549 and colon cancer HCT-116 cell lines. Compound 3n exhibited
      the most cytotoxic effect on A549 cells with an IC50 value of 4.87 MUM, inducing
      a cell cycle arrest at G2/M phase and activating the spindle assembly checkpoint
      (SAC). To identify the target protein(s) of 3n, we incorporated biotin with 3n
      through a three-carbon chain and an amide bond to synthesize probe 10. The
      targeted proteins were pulled down from the A549 total cell lysate by biotin
      streptavidin affinity purification and analyzed by mass spectrometry. Tubulin was
      the only protein identified, which is related to the SAC and directly binds to
      probe 10 both in vivo and in vitro. Furthermore, compound 3n inhibited tubulin
      polymerization in vitro in a dose-dependent manner, competed with taxol in
      binding to tubulin, exerting cytotoxic activity toward taxol-resistant A549
      cells. These results demonstrate that thieno[2,3-d]pyrimidine derivative 3n
      exhibits cytotoxicity in cancer cells by targeting tubulin to activate the SAC
      and potentially acts as a therapeutic lead compound for taxol-resistant cancers.

PMID- 29843104
TI  - Nuclear event zero time determination using analytical solutions of radioxenon
      activities under in-growth condition.
AB  - Motivated by simplifying the calculation process of radioxenon isotopic activity
      used by scientist community in nuclear event characterization, the analytical
      formulas of the numbers of nuclides and isotopic activities of CTBT relevant
      radioxenon Xe-135, Xe-133m, Xe-133 and Xe-131m proposed in this work can be
      useful and incorporated in the calculation algorithms for nuclear event studies.
      The calculated ages using analytical formulas and radioxenon activity data from
      real observations compare well with the reported ages and show good results of
      event timing precision.

PMID- 29843105
TI  - Selenium accumulation and the effects on the liver of topmouth gudgeon
      Pseudorasbora parva exposed to dissolved inorganic selenium.
AB  - Selenite(IV) and selenate(VI) are the major forms of Se in aquatic ecosystem. In
      this study, Pseudorasbora parva were exposed to 10, 200 and 1000 MUg L-1 selenite
      and selenate for 28 days. Selenium accumulation, antioxidant enzyme levels,
      glutathione concentrations, lipid peroxidation and histology were evaluated in
      livers following exposure. Our results showed that Se(IV) and Se(VI) caused
      different accumulation patterns in the liver, with a more rapid accumulation of
      Se with Se(IV) treatment. Both Se species increased hepatic lipid peroxidation
      after 14 and 28 d (~ 30%). Among the antioxidants examined, the activity of SOD
      (except day 28) and the cellular levels of GSH were induced by 72-137% at lower
      concentrations, while the activity of GST was at least 24% lower than that of the
      control at 200 and 1000 MUg L-1 for both Se species at all sampling points. Both
      forms of Se reduced the hepatosomatic index at 1000 MUg L-1 after 28 d. In
      addition, marked histopathological alterations (10-31%) were observed in the
      liver of P. parva after exposure to both Se species, with higher frequency in the
      Se(IV) exposed fish. Liver local necrosis was observed only in the liver of fish
      exposed to 1000 MUg L-1 of Se(IV) (~ 20%). Our results suggest that the
      ecological impacts of dissolved Se in this freshwater species may also contribute
      to overall toxicity.

PMID- 29843106
TI  - Regression models evaluating THMs, HAAs and HANs formation upon chloramination of
      source water collected from Yangtze River Delta Region, China.
AB  - Present study aimed to generate multiple regression models to estimate the
      formation of trihalomethanes (THMs), haloacetonitriles (HANs) and haloacetic
      acids (HAAs) during chloramination of source water obtained from Yangtze River
      Delta Region, China. The results showed that the regression models for
      trichloromethane (TCM), dichloroacetonitrile (DCAN), dichloroacetic acid (DCAA),
      dihaloacetic acids (DHAAs), 5 HAAs species regulated by U.S. EPA (HAA5) and total
      haloacetic acids (HAA9) have good evaluation ability (prediction accuracy reached
      81-94%), while the models for total haloacetonitriles (HAN4), trichloroacetic
      acid (TCAA), trihaloacetic acids (THAAs) and total trihalomethanes (THM4), they
      appeared relative low prediction accuracy (58-72%). For THMs, dissolved organic
      nitrogen (DON) was their key organic precursor, yet for HAN, DHAAs and THAAs,
      UVA254 played the dominant role. The other key factors influencing DBP formation
      included the bromide (THM4, DHAAs and HAA9), reaction time (DCAN, HAN4),
      chloramine dose (TCM, DCAA, TCAA, HAA5 and THAAs). These results provided
      important information for water works to optimize the water treatment process to
      control DBPs, and give an evaluating method for DBPs levels when estimating the
      health risks related with DBP exposure during chloramination.

PMID- 29843107
TI  - MEK inhibition may increase survival of NRAS-mutated melanoma patients treated
      with checkpoint blockade: Results of a retrospective multicentre analysis of 364
      patients.
AB  - BACKGROUND: Melanoma harbours genetic alterations in genes such as BRAF, NRAS and
      KIT. Activating NRAS mutations are present in about 20% of melanomas. Even though
      BRAF mutations can be effectively targeted with specific inhibitors, this
      approach has proven more challenging in cases of NRAS mutations. Previous reports
      suggested that immunotherapy might be more successful in NRAS-mutated compared to
      BRAF-mutated or BRAF/NRAS wildtype melanoma. PATIENTS AND METHODS: In this study,
      overall survival and response to anti-PD-1 (nivolumab, pembrolizumab) and anti
      CTLA-4 (ipilimumab) therapy of 364 patients with metastatic melanoma were
      assessed comparing 236 NRAS-mutated patients with 128 NRAS wildtype patients.
      Subtyping of NRAS mutation in 211 cases revealed 12 different genotypes of which
      Q61 mutations were predominant (95%). RESULTS: Patients with NRAS mutant melanoma
      showed similar response rates to checkpoint inhibitor therapy compared to NRAS
      wildtype patients with 15% versus 13% for ipilimumab (P = 0.731), 21% versus 13%
      for anti-PD-1 monotherapy (P = 0.210) and 40% versus 39% for ipilimumab and anti
      PD-1 therapy in combination or sequence (P = 0.859). Nevertheless, median overall
      survival of patients with NRAS mutant melanoma was significantly lower with 21
      months compared to 33 months in NRAS wildtype melanoma patients (P = 0.034).
      Therapy with oral MEK inhibitors before or after checkpoint inhibitor therapy
      showed a trend toward a survival benefit in patients with NRAS mutant melanoma.
      CONCLUSIONS: Immune checkpoint inhibition shows comparable response rates in NRAS
      mutated and NRAS wildtype melanoma even though survival is less favourable in
      case of NRAS mutation. Additional MEK inhibition might improve clinical benefit.

PMID- 29843108
TI  - Binding mechanism investigations guiding the synthesis of novel condensed 1,4
      dihydropyridine derivatives with L-/T-type calcium channel blocking activity.
AB  - Nifedipine and isradipine are prominent examples of calcium channel blockers with
      a 1,4-dihydropyridine (DHP) scaffold. Although successfully used in clinics since
      decades for the treatment of hypertension, the binding mechanism to their target,
      the L-type voltage-gated calcium channel Cav1.2, is still incompletely
      understood. Recently, novel DHP derivatives with a condensed ring system have
      been discovered that show distinct selectivity profiles to different calcium
      channel subtypes. This property renders this DHP class as a promising tool to
      achieve selectivity towards distinct calcium channel subtypes. In this study, we
      identified a common binding mode for prominent DHPs nifedipine and isradipine
      using docking and pharmacophore analysis that is also able to explain the
      structure-activity relationship of a small subseries of DHP derivatives with a
      condensed ring system. These findings were used to guide the synthesis of twenty
      two novel DHPs. An extensive characterization using 1H NMR, 13C NMR, mass spectra
      and elemental analysis was followed by whole cell patch clamp assays for
      analyzing activity at Cav1.2 and Cav3.2. Two compounds were identified with
      significant activity against Cav1.2. Additionally, we identified four compounds
      active against Cav3.2 of which three were selective over Cav1.2. Novel binding
      modes were analyzed using docking and pharmacophore analysis as well as molecular
      dynamics simulations.

PMID- 29843109
TI  - Is family history of alcohol dependence a risk factor for disturbed sleep in
      alcohol dependent subjects?
AB  - BACKGROUND: Disturbed sleep and a family history of alcohol dependence (AD) are
      risk factors for developing AD, yet the underlying relationship between them is
      unclear among individuals with AD. Understanding these inherited associations
      will help us not only identify risk for development of these comorbid disorders,
      but also individualize treatment at this interface. We evaluated whether a first
      degree family history of AD (FH+) was a risk factor for sleep continuity
      disturbance in patients with AD. We also evaluated whether alcohol use or mood
      disturbance moderated the relationship between FH and sleep. METHODS: We analyzed
      cross-sectional baseline data from an alcohol clinical trial in a sample of
      individuals with AD (N = 280). Their family history of AD among nuclear family
      members, sleep complaints, alcohol use (over the last 90 days), and mood
      disturbance were assessed using the Family History Interview for Substance and
      Mood Disorders, Medical Outcomes Study Sleep Scale, Time Line Follow-Back
      Interview, and Profile of Mood States-Short Form, respectively. RESULTS: A FH +
      status (65% of subjects) was significantly associated with lower model estimated
      mean sleep adequacy (beta = - 7.05, p = 0.02) and sleep duration (beta = - 0.38,
      p = 0.04) scale scores. FH was not associated with sleep disturbance scale. No
      significant moderating effect involving alcohol use or mood disturbance was seen.
      CONCLUSION: Family history of AD is a unique risk factor for sleep complaints in
      AD. Non-restorative sleep and sleep duration may be noteworthy phenotypes to help
      probe for underlying genotypic polymorphisms in these comorbid disorders.

PMID- 29843110
TI  - Association between cytochrome P450 2D6 polymorphisms and body fluid
      methamphetamine concentrations in Japanese forensic autopsy cases.
AB  - Methamphetamine (MA) is an illicit stimulant that affects the central nervous
      system. Cytochrome P450 2D6 (CYP2D6) plays an important role in MA metabolism.
      Numerous allelic variants confer substantial variation in CYP2D6 activity among
      individuals. In the present study, we examined the frequencies of CYP2D6 alleles,
      including CYP2D6*1, *2, *4, *5, *10, *14A, *14B, *18, and *36, and
      multiplication, in 82 forensic autopsy cases of MA abusers and 567 autopsy cases
      in which MA was not detected (controls). Ultrarapid metabolizer (UM), extensive
      metabolizer (EM), intermediate metabolizer (IM), and poor metabolizer (PM)
      phenotypes were predicted from CYP2D6 genotypes. Of MA abusers, 64 subjects were
      predicted to be EM, 17 were IM, and 1 was UM. No MA abuser had the predicted PM
      phenotype. No significant differences in CYP2D6 phenotype frequencies were found
      between MA abusers and controls. MA and amphetamine (AMP) concentrations were
      measured in the right heart blood, left heart blood, peripheral external iliac
      blood, urine, pericardial fluid, and bone marrow of MA abusers. MA concentrations
      in urine and bone marrow were significantly higher in IM than in EM. AMP
      concentration was not associated with CYP2D6 phenotype in any body fluid. These
      results suggest that the MA concentration in body fluids is influenced by CYP2D6
      phenotypes in the Japanese population.

PMID- 29843111
TI  - Microwave-assisted efficient depolymerization of alkaline lignin in
      methanol/formic acid media.
AB  - Microwave-assisted degradation of alkaline lignin in methanol/formic acid media
      was investigated, concerning the effect of formic acid (FA) amount, reaction
      temperature, and reaction time on lignin depolymerization. The highest bio-oil
      yield of 72.0 wt% including 6.7 wt% monomers was achieved at 160  degrees C and a
      FA-to-lignin mass ratio of 4 after a reaction time of 30 min. Among the monomers,
      the yield of 2,3-dihydrobenzofuran was the highest (3.00 wt%), followed by p
      coumaric acid (1.59 wt%). Formic acid acted mainly through acid-catalyzed
      cleavage of the linkages in lignin. Oligomers in bio-oil were mainly composed of
      dimers (molecular weight: 253-378) and trimers (molecular weight: 379-510)
      according to the Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass
      Spectrometry (MALDI-TOF MS) analysis. A possible mechanism about microwave
      assisted depolymerization of lignin in methanol/formic acid media was proposed.
      This study will provide an efficient approach for lignin depolymerization.

PMID- 29843112
TI  - Biodesulfurization of sulfide wastewater for elemental sulfur recovery by
      isolated Halothiobacillus neapolitanus in an internal airlift loop reactor.
AB  - The biodesulfurization of sulfide wastewater for elemental sulfur recovery by
      isolated Halothiobacillus neapolitanus in an internal airlift loop reactor (IALR)
      was investigated. The flocculant producer Pseudomonas sp. strain N1-2 was used to
      deposit the produced elemental sulfur during biodesulfurization. The functional
      group analysis indicated that biofloculation was closely associated with NH and
      CO. The biodesulfurization system performed well under moderate water quality
      fluctuations (1.29-3.88 kg.m-3.d-1 COD; 1.54-3.08 kg.m-3.d-1.S2-) as it
      maintained stable S2- removal and sulfur flocculation rates. Meanwhile, the qRT
      PCR analysis indicated that the transcriptional level of cbbL decreased in the
      presence of organic carbon, while the expressions of sqr, sat, and cytochrome C3
      increased under higher sulfide stress. Moreover, the relative proportions of
      Halothiobacillus was strengthened via microbial intervention of the LJN1-3
      strain. The S2- removal efficiency and elemental sulfur production was further
      improved by 32.5% and 28.2%, respectively, in an IALR.

PMID- 29843113
TI  - Catalytic performance of quinone and graphene-modified polyurethane foam on the
      decolorization of azo dye Acid Red 18 by Shewanella sp. RQs-106.
AB  - Quinone-modified graphene powder is not reusable in bio-treatment systems, and
      the roles of quinone and graphene during extracellular electron-transfer
      processes remain unclear. In this study, we prepared anthraquinone-2-sulfonate
      and reduced graphene-oxide-modified polyurethane foam (AQS-rGO-PUF) and found
      that AQS-rGO-PUF exhibited higher catalytic performance on Acid Red 18 (AR 18)
      bio-decolorization compared with AQS-PUF and rGO-PUF. We observed a significant
      synergistic effect between AQS and rGO in AQS-rGO-PUF-mediated system in the
      presence of 50 MUM AQS and 1.63 mg/L rGO. The synergistic effect was mainly
      attributed to electron transfer from AQS to rGO either directly or via flavins
      secreted by strain RQs-106, and ultimately to AR 18, accounting for ~33.47% of AR
      18 removal during AQS-rGO-PUF-mediated decolorization. Additionally, AQS-rGO-PUF
      exhibited good mechanical properties and maintained its macroporous structure.
      Furthermore, after eight rounds of experiments using AQS-rGO-PUF, the bio
      decolorization efficiency of AR 18 retained >98.18% of its original value. These
      results indicate that the combination of AQS-rGO-PUF and Shewanella strains show
      potential efficacy for enhancing the treatment of azo-dye-containing wastewater.

PMID- 29843114
TI  - Auto-antibodies against the angiotensin II type I receptor in women with
      uteroplacental acute atherosis and preeclampsia at delivery and several years
      postpartum.
AB  - BACKGROUND: Uteroplacental acute atherosis is a pregnancy-specific lesion
      resembling early stages of atherosclerosis found frequently in preeclampsia.
      Preeclampsia is associated with an increased risk for future maternal
      atherosclerotic cardiovascular disease. The renin-angiotensin-system plays a role
      both in atherosclerosis and in preeclampsia. Circulating agonistic autoantibodies
      at the angiotensin-II type 1 receptor (AT1-AA) are increased in preeclampsia. We
      hypothesized an association between AT1-AA at delivery and postpartum with acute
      atherosis in pregnancy. MATERIAL AND METHODS: Maternal serum and decidua basalis
      tissue was collected at elective cesarean section (n = 41; 24 preeclampsia, 17
      normotensive controls). Circulating AT1-AA were detected by a bioassay using
      spontaneously beating rat cardiomyocytes at delivery (n = 41) and 5-8 years
      postpartum in a subgroup (n = 10). Decidual acute atherosis was assessed by
      immunohistochemistry. RESULTS: Significantly less normotensive controls (18%;
      3/17) than women with preeclampsia (58%; 14/24) were AT1-AA positive at delivery,
      p<0.01. Uteroplacental acute atherosis and circulating AT1-AA at delivery were
      not significantly correlated. Postpartum, 2 prior preeclamptic women had
      circulating AT1-AA, both without acute atherosis in pregnancy. CONCLUSIONS: Our
      results confirm that circulating AT1-AA are present significantly more often in
      preeclampsia than in normotensive pregnancy, however without association to acute
      atherosis. Whether circulating maternal AT1-AA or acute atherosis target young
      women at increased long-term cardiovascular risk warrants further investigations.

PMID- 29843116
TI  - Nontoxic fluorescent carbon nanodot serving as a light conversion material in
      plant for UV light utilization.
AB  - In this study, water-soluble fluorescent carbon nanodots (CNDs) were directly
      injected into the leaf of nicotiana tabacum. With the help of UV-to-blue light
      conversion nanomaterial, the photosynthetic rate of the leaf was improved 18%
      upon additional 6 W UV irradiation. The photostability and toxicity of different
      kinds of CNDs were discussed. The results showed that CNDs functionalized with
      NH2-groups on their surfaces could maintain good fluorescence in plant leaf, and
      CNDs with complex surface groups tended to have high toxicity to the plant. The
      NH2-functionalized CNDs with non-toxicity and good photostability were used as in
      vivo light conversion material for direct utilization of UV light in the solar
      energy.

PMID- 29843115
TI  - Expression of Androgen Receptor and Cancer Stem Cell Markers (CD44+/CD24- and
      ALDH1+): Prognostic Implications in Invasive Breast Cancer.
AB  - BACKGROUND: Androgen receptor (AR) has emerged as a significant prognostic marker
      in early breast cancer (BCa). Association of AR with cancer stem cell (CSC)
      markers in BCa is unknown. Aim of the present study was to evaluate the
      immunohistochemical expression of AR, CD44, CD24 and ALDH1 in a cohort of
      Pakistani patients diagnosed with invasive BCa and to correlate the expression
      with 5- year disease free survival. PATIENTS AND METHODS: We evaluated
      immunohistochemical expression AR, CD44, CD24 and ALDH1 in formalin fixed
      paraffin embedded archival blocks of 166 cases of primary invasive BCa (stage I
      III) and correlated the expression with clinicopathological variables and outcome
      using univariable and multivariable analysis. Survival data was computed by
      Kaplan Meier curves. RESULTS: Expression of AR was observed in 62.7% tumors
      whereas CD44, CD24 and ALDH1 were expressed in 61.4%, 44% and 30.1% tumors,
      respectively. AR expression was significantly associated with T1-T2 tumors, lower
      grade, estrogen and progesterone receptor expression (P < .05) and remained an
      independent prognostic indicator in multivariable analysis (adjusted HR 0.33, 95%
      CI 0.13-0.81; P = .016). Significant association was observed between concordant
      expression of AR and CD24 (P = .001) with a favorable impact on survival (P =
      .007) whereas expression of CSC phenotypes (CD44+, CD44+/CD24- and ALDH1+) did
      not correlate with adverse outcome (P > .05). However, AR expression retained the
      association with better prognosis even in patients whose tumors exhibited a CSC
      phenotype. CONCLUSIONS: Expression of AR and CD24 in stage I-III invasive BCa
      correlates with favorable clinicopathological features and delineates a subgroup
      of patients with better disease-free survival.

PMID- 29843117
TI  - Palladium nanoparticle-decorated 2-D graphene oxide for effective photodynamic
      and photothermal therapy of prostate solid tumors.
AB  - Intratumoral injection of nanoparticles is a viable alternative for treating
      solid tumors. In this study, we used intratumorally-injected palladium
      nanoparticle (Pd NP)-decorated graphene oxide (GO) (GO-Pd NPs) for the treatment
      of solid prostate tumors. GO was synthesized using the modified Hummer's method
      and GO-Pd NPs were prepared using the one pot synthesis method. Studies on
      physicochemical characterization and in vitro/in vivo anticancer properties were
      performed using GO-Pd NPs. Successful preparation of GO-Pd NPs was confirmed by
      transmission electron microscopy, Fourier transform infrared spectroscopy, energy
      dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Compared to
      GO or Pd NPs alone, GO-Pd NPs showed higher cytotoxic effects in prostate cancer
      3 (PC3) cells. Irradiation of treated cells with near infrared (NIR) laser
      considerably enhanced apoptosis induced by synergistic photothermal effect and
      reactive oxygen species (ROS) generation. Intratumorally-injected GO-Pd NPs
      showed promising in vivo localized distribution, photothermal ablation, and anti
      tumor effects in the PC3 xenograft mouse model. Furthermore, the minimal organ
      toxicity of GO-Pd NPs was an added advantage. Hence, GO-Pd NPs could be a
      potential formulation for localized treatment of prostate solid tumors.

PMID- 29843118
TI  - Whole body organization during a symmetric bimanual pick up task for children
      with unilateral cerebral palsy.
AB  - BACKGROUND: Information on whole-body coordination involving bimanual
      coordination for children with unilateral spastic cerebral palsy (USCP) is
      limited. RESEARCH QUESTION: The purpose of the current study is to test the
      hypothesis that during a whole-body pick up task, children with USCP will
      organize their whole- body movements and bimanual coordination differently than
      typically-developing children (TDC). METHODS: Twelve children with USCP (average
      age: 8.3; MACS levels: I-II) and twelve age-matched TDC participated in the
      study. Children were asked to reach down, grasp, and pick up an empty box to
      waist height while Kinematic and Kinetic data were recorded and analyzed using a
      VICON system and two AMTI force plates. RESULTS: Children with USCP had longer
      overall movement time, reaching down time, and grasping movement time (all P <
      0.05) than TDC. Less bimanual coordination was indicated by greater finger
      vertical position differences and movement onset and offset timing differences
      (all P < 0.05). Additionally, greater bilateral joint position on differences
      were found for shoulder, elbow, hip, and knee when reaching down and for shoulder
      and elbow at the end of the task (all P < 0.05). Greater asymmetric bilateral
      ground reaction force and greater lateral and anterior center of pressure
      excursion were also found in children with USCP (all P < 0.05). SIGNIFICANCE:
      Impairments in both bimanual and whole-body coordination were found during a
      simple whole-body task in children with USCP. Future treatments or assessments
      should consider whole-body tasks involving dual task constraints.

PMID- 29843119
TI  - Giant siliconoma mimicking locally advanced breast cancer: A case report and
      review of literature.
AB  - INTRODUCTION: Silicone prosthetics are widely used for breast augmentation and
      reconstruction. These devices may extrude free silicone into surrounding tissue,
      stimulating a granulomatous foreign body reaction. The resulting mass can mimic
      breast cancer. PRESENTATION OF CASE: 71 year old female with a history of a
      ruptured silicone implant presents with an enlarging left breast mass. Exam
      demonstrated and ulcerated, fungating mass with active infection. CT scan
      demonstrated a 23 * 15 cm mass involving the breast and chest wall with axillary
      lymphadenopathy. Preoperative biopsies were inconclusive and the patient
      underwent a modified radical mastectomy. Pathology demonstrated a siliconoma.
      DISCUSSION: While benign, silicone granulomas of the breast can present similarly
      to malignancy and are an important differential in the diagnosis of a breast or
      axillary mass for appropriate patients. MRI is the study of choice and core
      needle biopsies cannot always establish the diagnosis preoperatively. PET scans
      can be falsely positive and the diagnosis requires an extensive workup to rule
      out cancer. CONCLUSION: Siliconomas develop as a result of implant rupture and
      present with many of the signs and symptoms of breast cancer. The majority of
      patients should undergo surgery for symptom relief or to rule out cancer.

PMID- 29843120
TI  - Evaluation of the LC-1000 Flow Cytometry Screening System for Cervical Cancer
      Screening in Routine Health Checkups.
AB  - OBJECTIVE: This study evaluated the performance of a flow cytometry system (LC
      1000) in screening cervical precancerous lesions at routine health checkups.
      STUDY DESIGN: In total, 928 health examinees were enrolled at 16 health promotion
      centers in 13 Korean cities between 2016 and 2017. All participants underwent
      liquid-based cervical cytology and flow cytometry testing to determine the cell
      proliferation index (CPIx). RESULTS: The positivity rate of the LC-1000 system
      increased with the severity of the cervical cytology findings (p for trend <
      0.001). When low-grade squamous intraepithelial lesion (LSIL) or higher
      (including LSIL, high-grade squamous intraepithelial lesion [HSIL], and atypical
      squamous cells without excluding HSIL [ASC-H]) was defined as gold-standard
      positivity, the sensitivity, specificity, PPV, and NPV of LC-1000 were 75.3% (95%
      confidence interval [CI], 66.8-83.7), 58.5% (95% CI, 55.2-61.9), 18.1% (95% CI,
      14.5-21.8), and 95.1% [95% CI, 93.2-97.0], respectively. The median CPIx
      increased significantly from normal cytology to HSIL (p < 0.001). The median CPIx
      was higher in high-risk human papillomavirus (HR-HPV)-positive cases than in HR
      HPV-negative cases (0.23 vs. 0.17, p < 0.001), while it did not differ between HR
      HPV-positive and HR-HPV-negative cases with normal cytology findings (0.16 vs.
      0.16, p = 0.700). CONCLUSION: The LC-1000 system is potentially useful for
      screening cervical precancer and cancer, especially when excluding normal or ASC
      of undetermined significance cases in routinely screened populations.

PMID- 29843121
TI  - Alterations of Cortisol Metabolism in Human Disorders.
AB  - The interconversion of active and inactive corticosteroids - cortisol and
      cortisone, respectively, in humans - is modulated by isozymes of 11beta
      hydroxysteroid dehydrogenase (11-HSD). Studies of this process have provided
      crucial insights into glucocorticoid effects in a wide variety of tissues. The 11
      HSD1 isozyme functions mainly as an oxoreductase (cortisone to cortisol) and is
      expressed at high levels in the liver and other glucocorticoid target tissues.
      Because it is required for full physiological effects of cortisol, it has emerged
      as a drug target for metabolic syndrome and type 2 diabetes. Mutations in the
      corresponding HSD11B1 gene, or in the H6PD gene encoding hexose-6-phosphate
      dehydrogenase (which supplies the NADPH required for the oxoreductase activity of
      11-HSD1), cause apparent cortisone reductase deficiency, a rare syndrome of
      adrenocortical hyperactivity and hyperandrogenism. In contrast, the 11-HSD2
      isozyme functions as a dehydrogenase (cortisol to cortisone) and is expressed
      mainly in mineralocorticoid target tissues, where it bars access of cortisol to
      the mineralocorticoid receptor. Mutations in the HSD11B2 gene encoding 11-HSD2
      cause the syndrome of apparent mineralocorticoid excess, a severe form of
      familial hypertension. The role of this enzyme in the pathogenesis of common
      forms of low-renin hypertension remains uncertain.

PMID- 29843122
TI  - Comprehensive and Integrative Analysis Reveals the Diagnostic,
      Clinicopathological and Prognostic Significance of Polo-Like Kinase 1 in
      Hepatocellular Carcinoma.
AB  - BACKGROUND/AIMS: Liver cancer has the second highest cancer-related death rate
      globally and has relatively few targeted therapeutics. Polo-like kinase 1 (PLK1)
      is a fascinating trigger of the cell cycle; however, the still-rudimentary
      understanding of PLK1 at present is a significant barrier to its clinical
      applications. Here, we comprehensively clarified the clinicopathological value
      and potential functions of PLK1 in hepatocellular carcinoma (HCC). METHODS: HCC
      related microarrays, RNA-sequencing datasets and published studies were deeply
      mined and integrated from The Cancer Genome Atlas, Gene Expression Omnibus,
      ArrayExpress, Oncomine, literature databases, and immunohistochemistry
      experiments. Meanwhile, the associations between PLK1 expression and its
      clinicopathological implications and prognostic value in HCC patients were
      assessed. The standardized mean difference, summary receiver operating
      characteristic curve and the corresponding area under the curve, hazard ratios,
      odds ratios (ORs), and their 95% confidence intervals (CIs) were examined by
      STATA 12.0. Additionally, several bioinformatics methods were used to identify
      the potential function of PLK1 in HCC. RESULTS: Comprehensive analyses revealed
      that PLK1 was significantly increased in HCC (standardized mean difference =
      1.34, 95% CI: 1.03-1.65, P < 0.001). The results of diagnostic tests specified
      that in the summary receiver operating characteristic curve, the area under the
      curve was 0.88 (95% CI: 0.85-0.90). Furthermore, an elevated PLK1 level
      significantly predicted unfavorable overall survival (hazard ratio = 1.78, 95%
      CI: 1.10-2.88, P = 0.019) and was correlated with female gender (OR = 0.73, 95%
      CI: 0.56-0.95, P = 0.017), tumor thrombus (OR = 3.97, 95% CI: 1.46-10.78, P <
      0.001), metastasis (OR = 3.46, 95% CI: 1.33-9.01, P = 0.011), pathologic stage
      (OR = 1.56, 95% CI: 1.17-2.07, P = 0.002), Barcelona Clinic Liver Cancer stage
      (OR = 5.76, 95% CI: 2.17-15.28, P < 0.001) and histologic grade (OR = 2.33, 95%
      CI: 1.12-487, P = 0.024). Through bioinformatics methods, we determined that
      enhancing the proliferative effect of PLK1 in HCC was associated with a series of
      hub genes and the activation of the cell cycle pathway. CONCLUSIONS: These
      findings substantiated that PLK1 may be an independent prognostic biomarker in
      HCC and may facilitate the development of targeted precision oncology.

PMID- 29843123
TI  - The Critical Role of PTEN/PI3K/AKT Signaling Pathway in Shikonin-Induced
      Apoptosis and Proliferation Inhibition of Chronic Myeloid Leukemia.
AB  - BACKGROUND/AIMS: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm.
      Tyrosine kinase inhibitors (TKIs) are commonly used to treat CML; however, drug
      resistance of CML cells to TKIs has limited their clinical application. Shikonin,
      a traditional Chinese herb, has long been used to treat leukemia in China, but
      the roles and related molecular mechanisms of shikonin treatment in CML remain
      unclear. Here, we aimed to evaluate the effects of shikonin on the proliferation,
      apoptosis, and migration of K562 cells, a CML cell line. METHODS: Firstly, K562
      cell proliferation and apoptosis were tested by CCK8 assay and flow cytometry
      with Annexin V-FITC/PI staining. Cell migration was measured by Transwell
      migration assay. In addition, western blot was performed to determine the
      proteins (PI3K, Bax, Bcl-2, cleaved caspase-3, PTEN, p-AKT, AKT, CXCR4, SDF-1,
      CD44) involved in the mechanism of action of shikonin. Finally, neutrophils from
      peripheral blood of CML patients were obtained, and cell proliferation and
      apoptosis were tested by CCK8 assay and flow cytometry. RESULTS: Shikonin reduced
      the proliferation of K562 cells in a time- and dose-dependent manner and promoted
      the apoptosis of K562 cells. Moreover, shikonin increased the PTEN level and
      inactivated the PI3K/AKT signaling pathway, subsequently upregulating BAX in K562
      cells. In addition, shikonin could block K562 cell migration via the CXCR4/SDF-1
      axis. Finally, shikonin significantly inhibited the proliferation and promoted
      the apoptosis of neutrophils from CML patients. CONCLUSION: These results
      demonstrated that shikonin inhibits CML proliferation and migration and induces
      apoptosis by the PTEN/PI3K/AKT pathway, revealing the effects of shikonin therapy
      on CML.

PMID- 29843124
TI  - Fluid Intake Habits in Type 1 Diabetes Individuals during Typical Training Bouts.
AB  - BACKGROUND/AIMS: Hyperglycemia may influence the hydration status in diabetic
      individuals. During exercise, type 1 diabetes mellitus (T1DM) individuals may be
      challenged by a higher risk of dehydration due to a combination of fluid losses
      from sweat and increased urine output via glycosuria. So far, no study has
      characterised spontaneous fluid intake in T1DM individuals during active
      trainings. METHODS: A validated questionnaire was used to assess T1DM
      participants' diabetes therapy, sports characteristics and fluid intake during
      training; results were then compared to an age- and sport-matched sample of non
      diabetic individuals. RESULTS: Ninety individuals completed the survey (n = 45
      T1DM individuals, n = 45 matched controls). A proportion of T1DM -individuals
      reported blood glucose levels greater than 10.0 mmol at both the start (28.9%)
      and end (24.4%) of the exercise. The mean self-reported fluid intake was greater
      in T1DM (0.60 +/- 0.47 L.h-1) compared to that of the control (0.37 +/- 0.28 L.h
      1, p < 0.05). In spite of drinking fluid volumes in line with international
      guidelines, 84.4% of those with T1DM reported that they were still feeling
      thirsty at the end of their training session. CONCLUSIONS: T1DM individuals self
      report spontaneously consuming fluid adequate volumes suggested by sport
      nutrition guidelines for non-diabetic athletes. Discrepancies in the T1DM
      subjectively reported feelings of thirst suggest that more education on hydration
      during exercise is needed for this population to adequately compensate for
      elevated blood glucose levels. It remains to be established whether fluid volumes
      suggested for healthy athletes are adequate for maintaining euhydration in T1DM
      patients due to their altered diuresis.

PMID- 29843125
TI  - Mucin 4 Gene Silencing Reduces Oxidative Stress and Calcium Oxalate Crystal
      Formation in Renal Tubular Epithelial Cells Through the Extracellular Signal
      Regulated Kinase Signaling Pathway in Nephrolithiasis Rat Model.
AB  - BACKGROUND/AIMS: Nephrolithiasis plagues a great number of patients all over the
      world. Increasing evidence shows that the extracellular signal-regulated kinase
      (ERK) signaling pathway and renal tubular epithelial cell (RTEC) dysfunction and
      attrition are central to the pathogenesis of kidney diseases. Mucin 4 (MUC4) is
      reported as an activator of ERK signaling pathway in epithelial cells. In this
      study, using rat models of calcium oxalate (CaOx) nephrolithiasis, the present
      study aims to define the roles of MUC4 and ERK signaling pathway as contributors
      to oxidative stress and CaOx crystal formation in RTEC. METHODS: Data sets of
      nephrolithiasis were searched using GEO database and a heat flow map was drawn.
      Then MUC4 function was predicted. Wistar rats were prepared for the purpose of
      model establishment of ethylene glycol and ammonium chloride induced CaOx
      nephrolithiasis. In order to assess the detailed regulatory mechanism of MUC4
      silencing on the ERK signaling pathway and RTEC, we used recombinant plasmid to
      downregulate MUC4 expression in Wistar rat-based models. Samples from rat urine,
      serum and kidney tissues were reviewed to identify oxalic acid and calcium
      contents, BUN, Cr, Ca2+ and P3+ levels, calcium crystal formation in renal
      tubules and MUC4 positive expression rate. Finally, RT-qPCR, Western blot
      analysis, and ELISA were employed to access oxidative stress state and CaOx
      crystal formation in RTEC. RESULTS: Initially, MUC4 was found to have an
      influence on the process of nephrolithiasis. MUC4 was upregulated in the CaOx
      nephrolithiasis model rats. We proved that the silencing of MUC4 triggered the
      inactivation of ERK signaling pathway. Following the silencing of MUC4 or the
      inhibition of ERK signaling pathway, the oxalic acid and calcium contents in rat
      urine, BUN, Cr, Ca2+ and P3+ levels in rat serum, p-ERK1/2, MCP-1 and OPN
      expressions in RTEC and H2O2 and MDA levels in the cultured supernatant were
      downregulated, but the GSH-Px, CAT and SOD levels in the cultured supernatant
      were increased. Moreover, MUC4 silencing or ERK signaling pathway inactivation
      may decrease the formation of CaOx crystals. CONCLUSION: Taken together,
      silencing of MUC4 can inactivate the ERK signaling pathway and further restrain
      oxidative stress and CaOx crystal formation in RTEC. Thus, MUC4 represents a
      potential investigative focus target in nephrolithiasis.

PMID- 29843126
TI  - The Relationship between Cardiorespiratory Fitness and Montreal Cognitive
      Assessment Scores in Older Adults.
AB  - BACKGROUND: Relatively little is known regarding the association between
      objective measures of physical function such as cardiorespiratory fitness (CRF)
      and cognitive function tests in healthy older adults. OBJECTIVE: To evaluate the
      relationship between CRF and cognitive function in adults aged 55 and older.
      METHODS: Between 2008 and 2017, 4,931 men and women underwent a comprehensive
      preventive physical exam at the Cooper Clinic in Dallas, Texas. CRF was
      determined by duration of a maximal treadmill exercise test. Cognitive function
      was evaluated with the Montreal Cognitive Assessment (MoCA). In a multivariate
      model, adjusted odds ratios with 95% confidence intervals for MoCA scores < 26
      (i.e., cognitive impairment) were determined by using CRF as both a continuous
      and a categorical variable. RESULTS: The mean age of the sample was 61.0 +/- 6.0
      years; mean maximal MET values were 10.0 +/- 2.2. Mean MoCA scores were 26.9 +/-
      2.2; 23.4% of the sample had MoCA scores indicative of cognitive impairment. The
      odds ratio for cognitive impairment was 0.93 (0.88-0.97) per 1-MET increment in
      CRF. When examined as a categorical variable, and using the lowest CRF quintile
      as the referent, there was a significantly reduced likelihood for cognitive
      impairment across the remaining ordered CRF categories (p trend = 0.004).
      CONCLUSION: The association between CRF and MoCA score in older adults suggests
      that meeting or exceeding public health guidelines for physical activity is
      likely to increase CRF in low fit individuals, maintain CRF in those with a
      moderate to high level of CRF, and thereby help to maintain cognitive function in
      healthy older adults.

PMID- 29843127
TI  - Obesity and Migraine: Effect Modification by Gender and Perceived Stress.
AB  - BACKGROUND: The association between obesity and migraine has been established;
      however, it is unclear whether it varies by perceived stress within each gender.
      METHODS: This cross-sectional study used data from the ongoing NutriNet-Sante e
      cohort with enrollees from the general population. Anthropometric and migraine
      data were provided via self-report questionnaires (2013-2016). Migraine was
      defined using established criteria. Perceived stress was assessed with Cohen's
      Perceived Stress Scale-10. Associations were estimated via gender- and stress
      stratified multivariable polytomous logistic regression models. RESULTS: Among
      32,835 participants with complete data (75% women; mean age = 51.9 +/- 13.8
      years), 34% reported no headache, 44% non-migraine headache, and 22% migraine
      with or without aura during one's lifetime. In these groups, obesity was present
      in 8.6, 9.9, and 11.6%, respectively. Stress was a significant moderator of the
      obesity-migraine association only among women. The largest significant adjusted
      odds ratio (aOR) was found between obesity and migraine in women with high stress
      (aOR 1.61, 95% CI 1.35-1.91). CONCLUSIONS: We found support for gender- and
      stress-dependent associations between obesity and migraine using a large,
      heterogeneous adult sample. This underscores the need for evidence-based
      strategies for weight loss and stress reduction for female migraineurs.

PMID- 29843128
TI  - Zurampic Protects Pancreatic beta-Cells from High Uric Acid Induced-Damage by
      Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways.
AB  - BACKGROUND/AIMS: Zurampic is a US FDA approved drug for treatment of gout.
      However, the influence of Zurampic on pancreatic beta-cells remains unclear. The
      study aimed to evaluate the effects of Zurampic on high uric acid-induced damage
      of pancreatic beta-cells and the possible underlying mechanisms. METHODS: INS-1
      cells and primary rat islets were stimulated with Zurampic and the mRNA
      expression of urate transporter 1 (URAT1) was assessed by qRT-PCR. Cells were
      stimulated with uric acid or uric acid plus Zurampic, and cell viability,
      apoptosis and ROS release were measured by MTT and flow cytometry assays. Western
      blot analysis was performed to evaluate the expressions of active Caspase-3 and
      phosphorylation of AMPK and ERK. Finally, cells were stimulated with uric acid or
      uric acid plus Zurampic at low/high level of glucose (2.8/16.7 mM glucose), and
      the insulin release was assessed by ELISA. RESULTS: mRNA expression of URAT1 was
      decreased by Zurampic in a dose-dependent manner. Uric acid decreased cell
      viability, promoted cell apoptosis and induced ROS release. Uric acid-induced
      alterations could be reversed by Zurampic. Activation of Caspase-3 and
      phosphorylation of AMPK and ERK were enhanced by uric acid, and the enhancements
      were reversed by Zurampic. Decreased phosphorylation of AMPK and ERK, induced by
      Zurampic, was further reduced by adding inhibitor of AMPK or ERK. Besides, uric
      acid inhibited high glucose-induced insulin secretion and the inhibition was
      rescued by Zurampic. CONCLUSIONS: Zurampic has a protective effect on pancreatic
      beta-cells against uric acid induced-damage by inhibiting URAT1 and inactivating
      the ROS/AMPK/ERK pathway.

PMID- 29843129
TI  - Appetite-Related Eating Behaviours: An Overview of Assessment Methods,
      Determinants and Effects on Children's Weight.
AB  - Identifying the underlying child-eating behaviours that contribute to weight
      differences across growth has been a constant challenge. This report reviews the
      various literature approaches for assessing appetite regulation. In doing so, it
      attempts to understand how appetite control develops and determines the eating
      habits in early childhood, and its effects on children's weight status. The
      interaction between homeostatic and hedonic mechanisms largely explains the
      appetite regulation process. Homeostatic mechanisms are mediated by the
      biological need to maintain the body's energy reserves, increasing the motivation
      to eat. On the contrary, the hedonic mechanisms are mediated by food reward,
      increasing the craving for high-palatable foods and triggering the release of
      dopamine and serotonin. There are many biological methods (plasma measurements of
      hormones, like leptin, ghrelin and insulin) and behavioural evaluation methods of
      appetite. The Children's Eating Behaviour Questionnaire is most commonly used,
      due to its adequate psychometric properties tested in several population
      settings. The development of eating behaviours begins in utero, and several
      determinants may contribute to a decrease in the ability to self-regulate dietary
      intake. Examples include genetic predisposition, the first taste experiences and
      the family environment, a key determinant in this process. Several eating
      behaviours contribute most to childhood obesity. Among them, are the external
      eating (eating by external stimuli, such as the mere presence of the food or its
      smell), food restriction (which may potentiate the uninhibited increased intake
      of the restricted foods) and emotional eating (intake due to emotional
      variations, especially negative feelings). These eating behaviours have been
      linked to childhood obesity.

PMID- 29843130
TI  - Depletion of Cholesterol Reduces ENaC Activity by Decreasing Phosphatidylinositol
      4,5-Bisphosphate in Microvilli.
AB  - BACKGROUND/AIMS: The epithelial sodium channel (ENaC) in cortical collecting duct
      (CCD) principal cells plays a critical role in regulating systemic blood
      pressure. We have previously shown that cholesterol (Cho) in the apical cell
      membrane regulates ENaC; however, the underlying mechanism remains unclear.
      METHODS: Patch-clamp technique and confocal microscopy were used to evaluate ENaC
      activity and density. RESULTS: Here we show that extraction of membrane Cho with
      methyl-beta-cyclodextrin (MbetaCD) significantly reduced amiloride-sensitive
      current and ENaC single-channel activity. The effects were reproduced by
      inhibition of Cho synthesis in the cells with lovastatin. We have previously
      shown that phosphatidylinositol-4,5-bisphosphate (PIP2), an ENaC activator, is
      predominantly located in the microvilli, a specialized apical membrane domain.
      Here, our confocal microscopy data show that alpha-ENaC was co-localized with
      PIP2 in the microvilli and that Cho was also co-localized with PIP2 in the
      microvilli. Either extraction of Cho with MbetaCD or inhibition of Cho synthesis
      with lovastatin consistently reduced the levels of Cho, PIP2, and ENaC in the
      microvilli. CONCLUSIONS: Since PIP2 can directly stimulate ENaC and also affect
      ENaC trafficking, these data suggest that depletion of Cho reduces ENaC apical
      density and activity at least in part by decreasing PIP2 in the microvilli.

PMID- 29843131
TI  - Intermittent Hypoxia Disrupts Glucose Homeostasis in Liver Cells in an Insulin
      Dependent and Independent Manner.
AB  - BACKGROUND/AIMS: Obstructive sleep apnea is associated with diabetes and insulin
      resistance, but the underlying mechanisms remain unclear. The purpose of the
      current study was to determine the molecular effects of intermittent hypoxia (IH)
      on hepatic insulin signaling and glucose homeostasis, and whether c-Jun NH2
      terminal-kinase (JNK) contributed to metabolic responses to IH in liver cells.
      METHODS: The human HepG2 cells and rat FAO cells were exposed to 10, 30, 120, 240
      or 360 cycles of IH (1% O2 for 60 s followed by 21% O2 for 60s, 7.5 cycles per
      hour) or normoxia as a control. In a subgroup, we exposed cells to 360 cycles of
      IH with the JNK inhibitor SP600125. After IH exposure, cell glycogen content and
      glucose output were measured using colorimetric assay kits. Canonical insulin
      signaling and gluconeogenic genes were measured by western blot and quantitative
      polymerase chain reaction. RESULTS: IH decreased insulin-stimulated protein
      kinase B (AKT)/glycogen synthase kinase-3beta (GSK-3beta) phosphorylation in a
      time-dependent manner, while inhibiting forkhead box protein O1 (FOXO1)
      expression and phosphoenolpyruvate carboxykinase (PEPCK) transcription
      independent of insulin signaling. JNK inhibitor SP600125 partially restored AKT/
      GSK-3beta phosphorylation and glycogen synthesis, but did not affect other IH
      induced glucose metabolic changes. CONCLUSION: IH in vitro impaired insulin
      signal transduction in liver cells as assessed by inhibited AKT/GSK-3beta
      phosphorylation via JNK activation. IH inhibited FOXO1 and gluconeogenesis in an
      insulin-independent manner.

PMID- 29843132
TI  - Experience of a Tertiary-Level Urology Center in the Clinical Urological Events
      of Rare and Very Rare Incidence. III. Psychourological Events: 1. Psychic Anuria.
AB  - INTRODUCTION: Psychic anuria is an old term, referring to a very rare psycho
      urological event that has scarcely been studied so far. MATERIALS AND METHODS: A
      retrospective study of the patients with psychic anuria presented to Assiut
      Urology and Nephrology Hospital during the period July 1991-June 2016 was done.
      Psychic anuria was defined, and the demographic and clinical characteristics
      including the methods of diagnosis and management were studied. RESULTS: Of more
      than 3,800 cases of anuria, 9 female patients (0.24%) experienced psychic anuria
      in the age range of 17-43 years. Cardinal clinical findings included anuria for
      36-72 h with absence of organic causes and normal renal function tests.
      Psychosocial risk factors were reported in the 9 cases. Anuria was documented by
      reliable history (56%) or observable urine collection (44%). Diagnosis was done
      by exclusion, where the investigations revealed no organic causes. Seven cases
      responded to the placebo intervention and 2 cases were self-limiting and resolved
      spontaneously. CONCLUSIONS: Psychic anuria is an extremely rare urological
      emergency that presents, mainly, in young adult females with unknown mechanisms.
      Renal vasoconstriction following psychosocial stressors is suggested. It is
      diagnosed by exclusion and resolves spontaneously or responds to placebo
      intervention as a mental distraction technique.

PMID- 29843134
TI  - Effect of Emotion and Type of Encoding on Memory for Actions: Verbal and Subject
      Performed Tasks.
AB  - BACKGROUND: The present study examines whether the interaction between emotion
      and the enactment effect (body involvement) improves memory in people with
      Alzheimer disease (AD). METHODS: Two experiments with drawings of actions were
      conducted, in which two types of encoding were used: motor and verbal. In
      experiment 1, with 13 AD patients and 13 older healthy adults, the encoding was
      incidental. In experiment 2, with 17 mild AD patients and 21 older healthy
      adults, it was intentional. RESULTS: In experiment 1, no effect of enactment or
      emotion was observed in the AD patients. In experiment 2, effects of enactment
      and emotion (better recall for negative actions) were observed in the AD
      patients. This pattern of results was also observed in the elderly control adults
      in both experiments. CONCLUSION: These results confirm effects observed in normal
      ageing and indicate a more subtle effect on AD.

PMID- 29843133
TI  - Niclosamide Exhibits Potent Anticancer Activity and Synergizes with Sorafenib in
      Human Renal Cell Cancer Cells.
AB  - BACKGROUND/AIMS: As the most lethal urological cancers, renal cell carcinoma
      (RCC) comprises a heterogeneous group of cancer with diverse genetic and
      molecular alterations. There is an unmet clinical need to develop efficacious
      therapeutics for advanced, metastatic and/or relapsed RCC. Here, we investigate
      whether anthelmintic drug Niclosamide exhibits anticancer activity and synergizes
      with targeted therapy Sorafenib in suppressing RCC cell proliferation. METHODS:
      Cell proliferation and migration were assessed by Crystal violet staining, WST-1
      assay, cell wounding and cell cycle analysis. Gene expression was assessed by
      qPCR. In vivo anticancer activity was assessed in xenograft tumor model. RESULTS:
      We find that Niclosamide effectively inhibits cell proliferation, cell migration
      and cell cycle progression, and induces apoptosis in human renal cancer cells.
      Mechanistically, Niclosamide inhibits the expression of C-MYC and E2F1 while
      inducing the expression of PTEN in RCC cells. Niclosamide is further shown to
      synergize with Sorafenib in suppressing RCC cell proliferation and survival. In
      the xenograft tumor model, Niclosamide is shown to effectively inhibit tumor
      growth and suppress RCC cell proliferation. CONCLUSIONS: Niclosamide may be
      repurposed as a potent anticancer agent, which can potentiate the anticancer
      activity of the other agents targeting different signaling pathways in the
      treatment of human RCC.

PMID- 29843135
TI  - Circulating alpha-Klotho is Related to Plasma Aldosterone and Its Follow-Up
      Change Predicts CKD Progression.
AB  - BACKGROUND/AIMS: We aimed to determine if soluble alpha-klotho level was an
      indicator of chronic kidney disease (CKD) progression and whether alpha-klotho
      interacted with aldosterone during the course of further renal damage. METHODS:
      112 adults with stages 1-5 CKD were enrolled into our cohort study. All of the
      patients were followed up for 6 years (from January 2010 to December 2015). Serum
      soluble alpha-klotho and aldosterone were measured at baseline and at 1.5-years
      follow-up. The primary outcome was the initiation of renal replacement therapy
      (RRT) and the secondary outcome was the occurrence of cardio-cerebrovascular
      events. Long-term progression to RRT and cardio-cerebrovascular events in
      patients was analyzed with a risk-adjusted Cox proportional hazards regression
      model. Adjustment included age, gender, eGFR, mean arterial pressure, 24-h
      protein excretion and the change in alpha-klotho level from baseline at 1.5-years
      follow-up. RESULTS: Baseline circulating alpha-klotho levels were positively
      associated with baseline estimated glomerular filtration rate (eGFR; r = 0.224, p
      = 0.017), but not age, calcium, phosphate, or parathyroid hormone levels. The
      change in alpha-klotho level from baseline at 1.5-years follow-up (p = 0.002) was
      independently associated with renal replace treatment (RRT) initiation after
      adjustment for age, gender, eGFR, mean arterial pressure, and 24-h protein
      excretion in Cox regression analysis. Aldosterone levels were positively
      associated with CKD stage, and were inversely correlated with circulating alpha
      klotho levels. CONCLUSION: The change in concentration of soluble alpha-klotho
      during the 1.5-years follow-up was an indicator of CKD progression. Renal damage
      associated with a reduction of alpha-klotho may involve the upregulation of
      plasma aldosterone. Future studies are needed to validate our findings, and to
      investigate the underlying mechanism by which alpha-klotho and aldosterone may
      cause renal damage.

PMID- 29843136
TI  - The Effects of Angelica Sinensis Polysaccharide on Tumor Growth and Iron
      Metabolism by Regulating Hepcidin in Tumor-Bearing Mice.
AB  - BACKGROUND/AIMS: Iron plays a fundamental role in cell biology and its
      concentration must be precisely regulated. It is well documented that excess iron
      burden contributes to the occurrence and progression of cancer. Hepcidin secreted
      by liver plays an essential role in orchestrating iron metabolism. In the present
      study, we aimed to investigate the ability of angelica sinensis polysaccharide
      (ASP) to decrease iron burden in tumor-bearing mice and the mechanism of ASP
      regulation hepcidin expression. METHODS: Western blot, RT-PCR,
      immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA) were
      used to detect the regulation of hepcidin and related cytokines by ASP. The role
      of ASP in tumor proliferation was investigated using in vivo assays. Iron
      depositions and iron concentrations in organs were determined by hematoxylin
      eosin (H&E) staining and atomic absorption spectrophotometer. RESULTS: We found
      that ASP could inhibit tumor growth in mice xenografted with 4T1 and H22 cancer
      cells. In vivo experiments also showed that ASP could potently regulate hepcidin
      expression in liver and serum and decrease iron burden in liver, spleen and
      grafted tumors in mouse model. Treatment with ASP in hepatic cell lines
      reproduced comparable results in decreasing hepcidin as in mouse liver.
      Furthermore, we found that ASP markedly suppressed the expression of interleukin
      6 (IL-6), JAK2, p-STAT3, and p-SMAD1/5/8 in liver, suggesting that JAK/STAT and
      BMP-SMAD pathways were involved in the regulation of hepcidin expression by ASP.
      We also found down-regulation of iron-related cytokines in ASP treated mice.
      CONCLUSION: The present study provides new evidence that ASP decreases hepcidin
      expression, which can reduce iron burden and inhibit tumor proliferation. These
      findings might aid ASP developed as a potential candidate for cancer treatment in
      patients with iron overload.

PMID- 29843137
TI  - Reactive Astrogliosis in an Experimental Model of Fibromyalgia: Effect of
      Dexmedetomidine.
AB  - To our knowledge, this is the first study which investigates the induction of
      neuroinflammation in rats using an acidic-saline model of fibromyalgia. It is
      well known that the hippocampus has a fundamental role in pain perception, and
      astrocytes play a crucial role in pain signaling. Our aim is to evaluate the
      ability of dexmedetomidine to attenuate the inflammatory responses induced in
      astrocytes. In a group of healthy rats, induction of chronic muscle pain by
      intramuscular injection of 100 uL of acidic saline on days 0 and 5 resulted in
      peripheral sensitization (measured using the von Frey test) and significant (p <
      0.05) increases in IL-1beta (160.2 +/- 1.1 to 335.2 +/- 1.8), IL-6 (100.1 +/- 1.4
      to 202.4 +/- 1.1), and TNF-alpha (60.0 +/- 0.7 to 115.5 +/- 1). Light and
      electron microscopy revealed degenerative changes in the hippocampus and reactive
      astrogliosis. Immunohistochemistry showed increased expression of glial
      fibrillary acid protein and inducible nitric oxide synthase. Surprisingly,
      treatment with a single dose of an alpha2-adrenergic agonist, dexmedetomidine (5
      ug/kg i.p.), attenuated these changes. This trial suggests that dexmedetomidine
      possibly directly acts on astrocytes, and a peripheral action is also suggested.

PMID- 29843138
TI  - HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer.
AB  - Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are
      longer than 200 nucleotides without protein-coding potential and function as
      novel master regulators in various human diseases, including cancer. Accumulating
      evidence shows that lncRNAs are dysregulated and implicated in various aspects of
      cellular homeostasis, such as proliferation, apoptosis, mobility, invasion,
      metastasis, chromatin remodeling, gene transcription, and post-transcriptional
      processing. However, the mechanisms by which lncRNAs regulate various biological
      functions in human diseases have yet to be determined. HOX antisense intergenic
      RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various
      areas of cancer, such as proliferation, survival, migration, drug resistance, and
      genomic stability. In this review, we briefly introduce the concept,
      identification, and biological functions of HOTAIR. We then describe the
      involvement of HOTAIR that has been associated with tumorigenesis, growth,
      invasion, cancer stem cell differentiation, metastasis, and drug resistance in
      cancer. We also discuss emerging insights into the role of HOTAIR as potential
      biomarkers and therapeutic targets for novel treatment paradigms in cancer.

PMID- 29843139
TI  - HSP70/HSP90-Organizing Protein Contributes to Gastric Cancer Progression in an
      Autocrine Fashion and Predicts Poor Survival in Gastric Cancer.
AB  - BACKGROUND/AIMS: HSP70/HSP90-organizing protein (HOP) is an adaptor protein that
      mediates heat shock protein 70 (HSP70) and HSP90 folding. HOP can be secreted by
      cancer cells and promote malignant cell growth in an autocrine manner. Here, we
      studied its role in gastric cancer (GC). METHODS: HOP mRNA and protein levels
      were detected by quantitative real-time PCR and western blotting, respectively,
      and enzyme-linked immunosorbent assay was used to determine the serum levels.
      Immunohistochemistry was performed to analyze HOP expression in 117 GC tissues
      and 32 adjacent normal tissues. The Cell Counting Kit-8 cell viability assay,
      flow cytometry, and western blotting were used to analyze the effects of HOP on
      cell proliferation and apoptosis, and the potential underlying mechanisms.
      RESULTS: HOP mRNA and protein levels were significantly higher in GC tissues than
      in normal tissues in our medical center (P< 0.001) and in The Cancer Genome Atlas
      database (P< 0.001). GC patients had higher serum levels of HOP than age-matched
      healthy controls (P< 0.001); however, once tumors were removed, serum levels
      significantly decreased (P< 0.01). In human GC tissues, increased HOP expression
      was associated with tumor progression and poor survival. Notably, autocrine HOP
      promoted cell proliferation through the phospholipase Cgamma1-extracellular
      signal-regulated kinase 1/2-dependent pathway, and inhibited cell apoptosis by
      regulating the activities of caspase 9, caspase 3, and B-cell lymphoma 2.
      Blocking extracellular HOP with neutralizing antibody reduced proliferation and
      enhanced fluorouracil-induced apoptosis of GC cells. CONCLUSIONS: Our findings
      demonstrate that HOP is an important molecular marker and prognostic factor for
      GC, and functionally contributes to tumor cell growth and survival. These results
      provide a rationale for considering HOP as a potential therapeutic target and
      chemosensitizer in GC.

PMID- 29843140
TI  - Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in
      Elderly Mice.
AB  - BACKGROUND: Pseudomonas aeruginosa (PS) infection results in severe morbidity and
      mortality, especially in immune-deficient populations. Aerobic exercise (AE)
      modulates the immune system, but its effects on the outcomes of pulmonary PS
      infection in elderly mice are unknown. METHODS: BALB/c mice (24 weeks old) were
      randomized to sedentary, exercise (EX), PS, and PS + EX groups for the acute
      experimental setting, and PS and PS + EX groups for the chronic setting. Low
      intensity AE was performed for 5 weeks, 60 min/day; 24 h after the final AE
      session, mice were inoculated with 5 * 104 colony-forming units (CFU) of PS, and
      24 h and 14 days after PS inoculation, mice were studied. RESULTS: AE inhibited
      PS colonization (p < 0.001) and lung inflammation (total cells, neutrophils,
      lymphocytes [p < 0.01] in bronchoalveolar lavage [BAL]), with significant
      differences in BAL levels of IL-1beta (p < 0.001), IL-6 (p < 0.01), CXCL1 (p <
      0.001), and TNF-alpha (p < 0.001), as well as parenchymal neutrophils (p <
      0.001). AE increased BAL levels of IL-10 and parenchymal (p < 0.001) and
      epithelial (p < 0.001) IL-10 expression, while epithelial (p < 0.001) and
      parenchymal (p < 0.001) NF-kappaB expression was decreased. AE diminished
      pulmonary lipid peroxidation (p < 0.001) and increased glutathione peroxidase (p
      < 0.01). Pre-incubation of BEAS-2B with IL-10 inhibited PS-induced epithelial
      cell expression of TNF-alpha (p < 0.05), CD40 (p < 0.01), and
      dichlorodihydrofluorescein diacetate (p < 0.05). CONCLUSIONS: AE inhibits PS
      induced lung inflammation and bacterial colonization in elderly mice, involving
      IL-10/NF-kappaB, and redox signaling.

PMID- 29843141
TI  - A Novel LncRNA-miRNA-mRNA Triple Network Identifies LncRNA RP11-363E7.4 as An
      Important Regulator of miRNA and Gene Expression in Gastric Cancer.
AB  - BACKGROUND/AIMS: Recent evidence has shown that some long non-coding RNAs
      (lncRNAs) play important roles in various biological processes. However, the
      regulatory mechanism of lncRNA in gastric cancer (GC) remains unclear. METHODS:
      We reannotated the GC gene expression profile into a lncRNA-mRNA biphasic profile
      and integrated the microRNA target data to construct a global GC triple network.
      A further clustering and random walk with restart analyses was performed on the
      triple network from the level of topology analyses. Quantitative real-time PCR
      was used to determine expression of lncRNA RP11-363E7.4. Kaplan-Meier analyses
      was performed to evaluate the prognostic value of lncRNA RP11-363E7.4. RESULTS:
      We constructed a gastric cancer lncRNA-miRNA-mRNA network (GCLMN) including six
      lncRNAs, 332 mRNAs, and 3,707 edges. For the shared lncRNA RP11-363E7.4, the
      interacting gene and microRNA functional enrichment studies implied that lncRNA
      RP11-363E7.4 might function as a new regulator in GC. The expression of lncRNA
      RP11-363E7.4 was downregulated compared with that of paracarcinoma tissues in
      five GC samples. High expression of lncRNA RP11-363E7.4 was found to be
      correlated to better overall survival (OS) for GC patients. CONCLUSIONS: This
      study focused on GC lncRNA-miRNA-mRNA regulatory networks, and found that lncRNA
      RP11-363E7.4 was a new GC risk lncRNA, which might provide novel insight into a
      better understanding of the pathogenesis of GC.

PMID- 29843143
TI  - The Role of Salvage High-Dose Chemotherapy in Relapsed Male Germ Cell Tumors.
AB  - Germ cell tumors (GCT) are a unique tumor entity with excellent cure rates if
      guideline-endorsed treatment is thoroughly applied. Even patients with widespread
      metastatic disease can often be cured with cisplatin-based combination
      chemotherapy as part of a multimodal treatment approach. However, about 30% of
      patients with metastatic disease at initial presentation, corresponding to about
      5-10% of all GCT patients, relapse or progress despite first-line treatment and
      therefore require salvage chemotherapy. Salvage systemic treatment either
      consists of conventional-dose cisplatin-based combination chemotherapy or
      sequential high-dose treatment with carboplatin and etoposide plus subsequent
      autologous stem cell support. This review is based on a comprehensive literature
      search of MEDLINE and conference proceedings of ESMO, ASCO, and EAU meetings
      until 2018 and provides an overview of current treatment options for germ cell
      cancer patients relapsing after or progressing during first-line cisplatin-based
      combination chemotherapy.

PMID- 29843142
TI  - Aromatase/Seladin-1 Interactions in Human Neuronal Cell Culture, the Hippocampus
      of Healthy Rats and Transgenic Alzheimer's Disease Mice.
AB  - BACKGROUND/AIMS: Decreasing levels of aromatase and seladin-1 could be one of the
      molecular mechanisms of Alzheimer's disease (AD). Aromatase is an enzyme that
      catalyzes estrogen biosynthesis from androgen precursors, and seladin-1 is an
      enzyme that converts desmosterol to cholesterol, which is the precursor of all
      hormones. Verifying the potential relationship between these proteins and
      accordingly determining new therapeutic targets constitute the aims of this
      study. METHODS: Changes in protein levels were compared in vitro in aromatase and
      seladin-1 inhibitor-administered human neuroblastoma (SH-SY5Y) cells in vivo in
      intracerebroventricular (icv) aromatase or seladin-1 inhibitor-administered rats,
      as well as in transgenic AD mice in which the genes encoding these proteins were
      knocked out. RESULTS AND CONCLUSIONS: In the cell cultures, we observed that
      seladin-1 protein levels increased after aromatase enzyme inhibition. The
      hippocampal aromatase protein levels decreased following chronic seladin-1
      inhibition in icv inhibitor-administered rats; however, the aromatase levels in
      the dentate gyrus of seladin-1 knockout (SelKO) AD male mice increased. These
      findings indicate a partial relationship between these proteins and their roles
      in AD pathology.

PMID- 29843144
TI  - Erratum.

PMID- 29843145
TI  - Meetings and Conferences.

PMID- 29843146
TI  - Haploinsufficiency of the Mouse Atp6v1b1 Gene Leads to a Mild Acid-Base
      Disturbance with Implications for Kidney Stone Disease.
AB  - BACKGROUND/AIMS: Homozygous mutations or deletion of the ATP6V1B1 gene encoding
      for the B1 subunit of the vacuolar H+-ATPase leads to distal renal tubular
      acidosis in man and mice. In humans, heterozygous carriers of B1 mutations can
      develop incomplete dRTA with nephroclacinosis. Here, we investigated whether
      Atp6v1b1+/- mice also develop acid-base disturbances during an HCl acid load.
      METHODS: We subjected Atp6v1b1+/+, Atp6v1b1+/-, Atp6v1b1-/- to an HCl-load for 7
      days and investigated acid-base status, kidney function, and expression of renal
      acid-base transport proteins. RESULTS: Atp6v1b1-/- mice had more alkaline urine
      and low ammoniuria, whereas Atp6v1b1+/- mice showed no difference in their urine
      parameters but higher blood chloride and lower blood pCO2 compared to controls.
      Subcellular localization of a4 and B2 subunits of H+-ATPase were unchanged within
      the 3 genotypes and Atp6v1b1+/+ and Atp6v1b1+/- mice exhibited a similar luminal
      localization of B1 subunit in intercalated cells. However, B1, B2 and a4
      expression were decreased in renal membrane fractions from Atp6v1b1+/- mice
      compared to Atp6v1b1+/+ while B2 and a4 were unchanged and B1 protein was reduced
      in Atp6v1b+-/- kidneys. Compensatory mechanisms of B1 ablation were found only in
      the collecting duct with a down-regulation of pendrin in Atp6v1b1-/- mice.
      CONCLUSIONS: In conclusion, 1) Atp6v1b1+/- mice developed a mild incomplete dRTA.
      dRTA is partly compensated by respiration. 2) Compensatory mechanisms for the
      absence of B1 take place only in the collecting duct of Atp6v1b1-/- kidneys.

PMID- 29843147
TI  - Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer.
AB  - LL-37, the C-terminal peptide of human cathelicidin antimicrobial peptide (CAMP,
      hCAP18), reportedly increases resistance to microbial invasion and exerts
      important physiological functions in chemotaxis, promotion of wound closure, and
      angiogenesis. Accumulating evidence indicates that LL-37 also plays a significant
      role in human cancer. LL-37 induces tumorigenic effects in cancers of the ovary,
      lung, breast, prostate, pancreas, as well as in malignant melanoma and skin
      squamous cell carcinoma. In contrast, LL-37 displays an anti-cancer effect in
      colon cancer, gastric cancer, hematologic malignancy and oral squamous cell
      carcinoma. Mechanistically, LL-37-induced activation of membrane receptors and
      subsequent signaling pathways lead to alteration of cellular functions. Different
      membrane receptors on various cancer cells appear to be responsible for the
      tissue-specific effects of LL-37. Meanwhile, the findings that vitamin D
      dependent induction of cathelicidin in human macrophages activates the anti
      cancer activity of tumor-associated macrophages (TAMs) and enhances antibody
      dependent cellular cytotoxicity (ADCC) support critical roles of vitamin D
      dependent induction of cathelicidin in cancer progression. This review describes
      novel advances involving the roles and mechanisms of human cathelicidin LL-37 in
      cancer.

PMID- 29843148
TI  - Target Door-to-Needle Time for Tissue Plasminogen Activator Treatment with
      Magnetic Resonance Imaging Screening Can Be Reduced to 45 min.
AB  - OBJECTIVE: The purpose of this study was to demonstrate that the median door-to
      needle (DTN) time for intravenous tissue plasminogen activator (tPA) treatment
      can be reduced to 45 min in a primary stroke centre with MRI-based screening for
      acute ischaemic stroke (AIS). METHODS: From February 2015 to February 2017, the
      stroke unit of Perpignan general hospital, France, implemented a quality
      improvement (QI) process. During this period, patients who received tPA within
      4.5 h after AIS onset were included in the QI cohort. Their clinical
      characteristics and timing metrics were compared each semester and also with
      those of 135 consecutive patients with AIS treated by tPA during the 1-year pre
      QI period (pre-QI cohort). RESULTS: In the QI cohort, 274 patients (92.5%)
      underwent MRI screening. While the demographic and baseline characteristics were
      not significantly different between cohorts, the median DTN time was
      significantly lower in the QI than in the pre-QI cohort (52 vs. 84 min; p <
      0.00001). Within the QI cohort, the median DTN time for each semester decreased
      from 65 to 44 min (p < 0.00001) and the proportion of treated patients with a DTN
      time <=45 min increased from 25 to 58.9% (p < 0.0001). Overall, DTN time
      improvement was associated with a better outcome at 3 months (patients with a
      modified Rankin Scale score between 0 and 2: 61.8% in the QI vs. 39.3% in the pre
      QI cohort; p < 0.0001). CONCLUSIONS: A QI process can reduce the DTN within 45
      min with MRI as a screening tool.

PMID- 29843149
TI  - LINC01121 Inhibits Cell Apoptosis While Facilitating Proliferation, Migration,
      and Invasion Though Negative Regulation of the Camp/PKA Signaling Pathway via
      GLP1R.
AB  - BACKGROUND/AIMS: Pancreatic cancer is an aggressive malignancy as a result of
      highly metastatic potential. The current study was carried out to alter the
      expression of LINC01121 in pancreatic cancer, with the aim of elucidating its
      effects on the biological processes of cell proliferation, migration, invasion,
      and apoptosis. We hypothesized that both the GLP1R gene and cAMP/PKA signaling
      pathway participate in the aforementioned process. METHODS: Microarray data
      (GSE14245, GSE27890 and GSE16515) and annotating probe files linked to pancreatic
      cancer were downloaded through the GEO database. The Multi Experiment Matrix
      (MEM) site was used to predict the target gene of lncRNA. Both pancreatic cancer
      tissues (n = 56) and paracancerous tissues (n = 45) were collected from patients
      diagnosed with pancreatic cancer. Immunohistochemistry was applied to identify
      the positive expression rate of GLP1R protein. Isolated pancreatic cancer cells
      and PANC-1 cells were independently classified into the blank, negative control
      (NC), LINC01121 vector, siRNA-LINC01121, siRNA-GLP1R and siRNA-LINC01121 + siRNA
      GLP1R groups. Reverse transcription quantitative polymerase chain reaction (RT
      qPCR) and Western blot analysis were applied to detect the expressions of
      LINC01121, GLP1R, cAMP, PKA, CREB, Bcl-2, Bad and PCNA. Cell proliferation,
      migration, invasion, cycle progression, and apoptosis were examined by MTT assay,
      scratch test, Transwell assay and flow cytometry analyses of Annexin V-FITC/PI
      staining. RESULTS: Observations were made indicating that LINC01121 was highly
      expressed, while low expressions of GLP1R in pancreatic cancer were detected
      based on microarray data, which was largely in consistent with the data collected
      of LINC01121 and GLP1R within the tissues. The target prediction program and
      luciferase activity analysis was testament to the notion suggesting that GLP1R
      was indeed a target of LINC01121. In contrast to the blank and NC groups, the
      LINC01121 vector group exhibited increased expressions of LINC01121; decreased
      mRNA and protein levels of GLP1R, Bad, cAMP, and PKA; increased protein levels of
      CREB, Bcl-2, PCNA, p-PKA and p-CREB; increased cell proliferation, migration and
      invasion; and decreased cell apoptosis. There was no significant difference
      detected among the blank, NC, and siRNA-LINC01121 + siRNA-GLP1R groups, except
      that decreased LINC01121 expression was determined in the siRNA-LINC01121 + siRNA
      GLP1R group. Parallel data were observed in the pancreatic cancer cells and PANC
      1 cells. CONCLUSION: The current study presents evidence indicating that
      LINC01121 might inhibit apoptosis while acting to promote proliferation,
      migration, and invasion of pancreatic cancer cells, supplementing the stance held
      that LINC01121 functions as a tumor promoter by means of its involvement in the
      process of translational repression of the GLP1R and inhibition of the cAMP/PKA
      signaling pathway.

PMID- 29843150
TI  - Repetitive Transient Ischemia-Induced Cardiac Angiogenesis is Mediated by Camkii
      Activation.
AB  - BACKGROUND/AIMS: Coronary angiogenesis is an important protective mechanism in
      response to myocardial ischemia in coronary artery disease. However, the
      underlying mechanisms remain largely unclear. Here, we investigated the role of
      CaMKII activation in ischemia-induced cardiac angiogenesis. METHODS: Repetitive
      transient ischemia model was established in C57/BL6 mice by daily multiple
      episodes (3 times/day) of short time (5 min) occlusion of the left anterior
      descending coronary artery for 7 days. Coronary angiogenesis was detected by
      immunofluorescent staining. RT-qPCR and Western blot analyses were used to detect
      the mRNA and protein levels of CaMKII, p-CaMKII and VEGF. Primary cardiac
      microvascular endothelial cells (CMECs) were isolated to investigate the effects
      of KN93 on cell proliferation and migration in hypoxic condition. RESULTS: We
      found that angiogenesis was induced in the ischemic myocardium and suppressed by
      chronic intraperitoneal injection of CaMKII inhibitor KN93. RT-qPCR and Western
      blot analyses showed that myocardial ischemia induced an increased expression and
      autophosphorylation of CaMKII. VEGF expression was increased in the ischemia
      model but blunted by KN93. Moreover, KN93 suppressed the proliferation and
      migration of cardiac endothelial cells in hypoxic condition in which the protein
      expression of CaMKII, p-CaMKII and VEGF was increased. CONCLUSION: CaMKII is an
      important mediator for the ischemia-induced coronary angiogenesis, in which
      CaMKII-triggered VEGF expression plays a key role.

PMID- 29843151
TI  - Impact of Metamorphopsia on Quality of Life after Successful Retinal Detachment
      Surgery.
AB  - PURPOSE: To determine the impact of metamorphopsia on quality of life after
      successful retinal detachment (RD) surgery and to determine which retinal changes
      are related to the most severe distortions. DESIGN: This was a prospective,
      observational, consecutive study. METHODS: The study included 58 eyes of 58
      consecutive patients who underwent successful RD surgery. At 6 months
      postoperatively, the incidence and severity of metamorphopsia were assessed by a
      quality-of-life questionnaire. Microstructure retinal changes were studied with
      spectral domain optical coherence tomography (OCT). The questionnaire score was
      compared with pre- and postoperative OCT findings. RESULTS: Overall, 20 patients
      (34.5%) had metamorphopsia. Outer retinal folds (ORFs) and the macular status
      before surgery, together with postoperative ORFs and decrease in ellipsoid and/or
      interdigitation photoreceptor zone reflectivity, were identified as risk factors
      of developing metamorphopsia (relative risk, 1.7-4.8). The most severe visual
      distortions were associated with ORFs. CONCLUSION: Metamorphopsia is a frequent
      occurrence after RD surgery and its impact on patients' quality of life appears
      to be limited. While it may be difficult to prevent photoreceptor loss occurring
      after surgery, limiting postoperative ORFs may be helpful in reducing their
      incidence.

PMID- 29843152
TI  - Raddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and
      Subsequent JNK Activation to Promote Cell Apoptosis.
AB  - BACKGROUND/AIMS: Raddeanin A (RA), an active pharmacological ingredient from
      Anemone raddeana Regel, plays an important role in tumor suppression. In this
      study, we assessed the potentially therapeutic effect of RA on glioblastoma and
      its underlying mechanisms. METHODS: Cell viability was examined using the MTT
      assay. Invasive and migratory capacities were examined using Transwell and wound
      healing assays. Apoptosis was determined by Hoechst staining, flow cytometry,
      DCFH-fluorescent probe and immunohistochemical staining. Autophagy was detected
      by transmission electron microscopy and western blotting. A U251 glioma xenograft
      model was established to evaluate the effect of RA in vivo. RESULTS: The data
      demonstrated that RA inhibited viability, and abrogated the invasive/migratory
      abilities of glioblastoma cells. In addition, RA induced apoptosis by reactive
      oxygen species (ROS)/ Jun N-terminal kinase (JNK) signaling in glioblastoma.
      Conversely, the antioxidant N-Acetyl-L-cysteine (NAC) and pan-caspase inhibitor z
      VAD-fmk attenuated RA-induced apoptosis by scavenging ROS and inactivating
      caspase-3. Furthermore, the inhibition of autophagy by 3-MA exacerbated apoptosis
      through ROS generation and JNK phosphorylation. In vivo, RA exhibited a curative
      effect on U251-derived xenografts in nude mice. CONCLUSIONS: The results of this
      study suggest that RA suppressed the growth of glioblastoma, thus serving as a
      promising and potential strategy for glioblastoma chemotherapy.

PMID- 29843154
TI  - Erratum.

PMID- 29843153
TI  - Erythropoietin Protects the Kidney by Regulating the Effect of TNF-alpha in L
      NAME-Induced Hypertensive Rats.
AB  - BACKGROUND/AIMS: Hypertension is the leading cause of death worldwide. Chronic
      high blood pressure induces inflammation. Tumor necrosis factor (TNF)-alpha plays
      a major role in inflammation and also depresses the synthesis of erythropoietin,
      which exerts protective effects on tissue; however, the mechanism is still
      unclear. We investigated the protective effect of erythropoietin against tissue
      damage caused by hypertension in the kidney and whether this effect was
      suppressed by TNF-alpha. METHODS: First, we detected the optimum chronic dose for
      darbepoetin-alpha (Depo), which is a long-acting erythropoietin analog for rats.
      We separated 60 female adult rats into 6 groups: control, Nomega-nitro-L-arginine
      methyl ester hydrochloride (L-NAME), L-NAME+Depo, L-NAME+Remicade (an anti-TNF
      alpha antibody), L-NAME+Depo+Remicade, Depo, and control. After 1 month of
      treatment, we measured cardiovascular parameters, took blood samples, sacrificed
      the rats, and removed kidneys for analyses. RESULTS: The apoptotic index and the
      plasma and kidney mRNA levels of TNF-alpha increased in the L-NAME group and
      decreased in all other treatment groups. Macrophage accumulation increased in the
      L-NAME and L-NAME+Remicade groups, while it decreased in the Depo group. The mRNA
      abundance of TNF receptor 1 (TNFR1) decreased slightly in the Depo group and
      TNFR2 increased significantly in the same group. CONCLUSION: Erythropoietin
      protects kidney tissue against hypertension by preventing the apoptotic effects
      of TNF-alpha by blocking macrophage accumulation, decreasing TNF-alpha levels,
      and switching the TNF-alpha receptors from the apoptotic receptor TNFR1 to the
      proliferative receptor TNFR2.

PMID- 29843155
TI  - Hydrogen Sulfide Decreases Blood-Brain Barrier Damage via Regulating Protein
      Kinase C and Tight Junction After Cardiac Arrest in Rats.
AB  - BACKGROUND/AIMS: Hydrogen sulfide (H2S) can decrease blood-brain barrier (BBB)
      permeability after cardiac arrest (CA) and resuscitation; however, the underlying
      mechanisms are not understood clearly. METHODS: We investigated the effects of
      inhalation of H2S on CA and resuscitation in a rat model of CA. We used Evans
      blue to detect the integrity of BBB and Western blot to assess the activation of
      protein kinase c (PKC) isozymes and the expression of Claudin-5, Occludin, and ZO
      1. Neurological deficit scales and the 14-days survival rate were measured.
      RESULTS: We determined that inhalation of 40 p.p.m or 80 p.p.m H2S significantly
      decreased brain water content and Evans blue leakage, ameliorated neurologic
      deficit scale and improved 14-days survival rate. H2S inhibited the activation of
      PKC-alpha, beta I, beta II and delta, impelled the activation of PKC-epsilon, and
      increased the expression of Claudin-5, Occludin and ZO-1. CONCLUSIONS: H2S
      improved the integrity of BBB, mitigated brain edema; improved neurological
      outcome and 14-days survival rate in rats after CA and resuscitation. The
      beneficial effects of H2S may be associated with inhibiting the activation of PKC
      alpha, beta I, beta II and delta, promoting the activation of PKC-epsilon, and
      increasing the expression of Claudin-5, Occludin and ZO-1.

PMID- 29843156
TI  - Resveratrol Protects Murine Chondrogenic ATDC5 Cells Against LPS-Induced
      Inflammatory Injury Through Up-Regulating MiR-146b.
AB  - BACKGROUND/AIMS: Resveratrol (RSV) has been reported as a promising oral
      supplementation for osteoarthritis treatment, while the mechanism of its action
      is still unclear. The specific aim of this study is to decode one of the
      mechanisms by which RSV protects chondrocyte. METHODS: Mouse chondrogenic cell
      line ATDC5 was treated with 30 uM RSV for 24 h, and 10 ug/ml LPS for 12 h, after
      which cell viability, apoptosis, and the release of pro-inflammatory cytokines
      were assessed. The expression of miR-146b in ATDC5 cells was silenced by the
      specific inhibitor transfection, and then cell viability, apoptosis and
      inflammation were re-assessed. RESULTS: The IC50 value of LPS in ATDC5 cells was
      about 10.27 ug/ml. LPS with a dosage of 10 ug/ml repressed cell viability,
      induced apoptosis, and increased the release of IL-1beta, IL-6 and TNF-alpha. RSV
      pre-treatment (30 uM) significantly alleviated LPS-induced apoptosis and
      inflammation. More importantly, miR-146b was up-regulated by RSV, and the
      protective functions of RSV on ATDC5 cells were attenuated by miR-146b silence.
      Further, NF-kappaB and p38MAPK pathways were activated by LPS, and were
      deactivated by RSV. Besides, RSV-induced the deactivation of NF-kappaB and
      p38MAPK pathways was reversed by miR-146b silence. CONCLUSIONS: Our findings
      suggest that RSV protects ATDC5 cells from LPS-induced inflammatory and apoptotic
      injury via up-regulation of miR-146b and thereby deactivation of NF-kappaB and
      p38MAPK pathways.

PMID- 29843159
TI  - Video Comment on Andre A. Neves et al.

PMID- 29843160
TI  - Video Comment on Andrew C. Storm et al.

PMID- 29843161
TI  - Video Comment on Alberto Tringali et al.

PMID- 29843157
TI  - Barrett's Esophagus after Bimodality Therapy in Patients with Esophageal
      Adenocarcinoma.
AB  - INTRODUCTION: Barrett's esophagus (BE) may be present in patients with esophageal
      adenocarcinoma (EAC) after bimodality therapy (BMT). There is no specific
      guidance for follow-up of these patients with regard to the presence of BE or
      dysplasia. In this study, we assessed the outcomes of patients who, after BMT,
      had BE and those who did not. METHOD: Patients with EAC who had BMT were
      identified and analyzed retrospectively in two groups, with and without BE. We
      compared patient characteristics and outcome variables (local, distant, and no
      recurrence). RESULTS: Of 228 patients with EAC, 68 (29.8%) had BE before BMT.
      Ninety-eight (42.9%) had BE after BMT, and endoscopic intervention was done in 11
      (11.2%). With a median follow-up of 37 months, the presence of post-BMT BE was
      not significantly associated with overall survival (OS) and local recurrence-free
      survival (LRFS). Similarly, endoscopic intervention was not significantly
      associated with OS and LRFS. Fifty (73.5%) patients with BE before BMT had BE
      after BMT (p < 0.0001). CONCLUSION: The presence of BE after BMT was not
      associated with increased risk of local recurrence. The local recurrence rate was
      not influenced by endoscopic intervention. Prospective studies are warranted to
      generate guidance for intervention, if necessary, for this group of EAC patients.

PMID- 29843158
TI  - Factors associated with changing indications for adenotonsillectomy: A population
      based longitudinal study.
AB  - OBJECTIVE: Adenotonsillectomy (AT) is one of the most common surgical procedures
      performed in children and adults. We aim to assess the factors associated with
      changes in the incidence of and indications for AT using population-level data.
      STUDY DESIGN: This retrospective cohort study investigated patients who underwent
      AT between 1997 and 2010 by using data from the Taiwan National Health Insurance
      Research Database. We examined surgical rates and indications by the calendar
      year as well as age, sex, hospital level, and insured residence areas for the
      correlating factors. RESULTS: The average annual incidence rate of AT was 14.7
      per 100,000 individuals during 1997-2010. Pediatric (<18 years) patients
      represented 48.2% of the total AT population. More than 99% of the patients
      underwent the AT procedures as an inpatient intervention. Longitudinal data
      demonstrated an increasing trend in the pediatric AT rates from 1997
      (4.3/100,000) to 2010 (5.7/100,000) (p = 0.029). In the adult subgroup, a
      decreasing prevalence of infectious indications (p = 0.014) coincided with an
      increasing neoplastic indications (p = 0.001). In the pediatric subgroup, the
      prevalence of obstructive indications increased (p = 0.002). The logistic
      regression analyses indicated that the significant factors associated with the
      changing surgical indications for AT were the age in the adult subgroup and
      hospital level in the pediatric subgroup. CONCLUSIONS: This study revealed a low
      AT rate in Taiwan than that in other countries. Pediatric AT incidence increased
      during 1997-2010. Although a rising prevalence of obstructive and neoplastic
      indications was noted, infection remained the most common indications for AT. Age
      in the adult subgroup and hospital level in the pediatric subgroup were factors
      associated with the changing indications for AT.

PMID- 29843162
TI  - Finding the middle ground in bile duct injury: the evolving role of biliary
      rendezvous.

PMID- 29843163
TI  - Continuing progress in endoscopic drainage of walled-off pancreatic necrosis.

PMID- 29843164
TI  - Endoscopic submucosal dissection for large protruding colorectal neoplasms: it
      still is a challenging procedure!

PMID- 29843165
TI  - Efficacy of self-expandable metal stents compared with multiple plastic stents in
      benign biliary strictures.

PMID- 29843167
TI  - [French comment on article A double-reprocessing high-level disinfection protocol
      does not eliminate positive cultures from the elevators of duodenoscopes].

PMID- 29843166
TI  - [French comment on article Delineation of the extent of early gastric cancer by
      magnifying narrow-band imaging and chromoendoscopy: a multicenter randomized
      controlled trial].

PMID- 29843168
TI  - [French comment on article Early removal of biflanged metal stents in the
      management of pancreatic walled-off necrosis: a prospective study].

PMID- 29843169
TI  - [French comment on article Short-term outcomes following endoscopic submucosal
      dissection of large protruding colorectal neoplasms].

PMID- 29843170
TI  - Which mode and potency of electrocoagulation yields the Smallest Unobstructed
      Area of the Fallopian Tubes?
AB  - OBJECTIVE:  To determine which mode and potency of electrocoagulation, using a
      modern electrosurgical generator, yields the smallest unobstructed area of the
      Fallopian tubes. METHODS:  In an experimental study, tubes from 48 hysterectomies
      or tubal ligation were evaluated. Tubes were randomly allocated to one of the
      following groups: group A) 25 W x 5 seconds (n = 17); group B) 30 W x 5 seconds
      (n = 17); group C) 35 W x 5 seconds (n = 18), group D) 40 W x 5 seconds (n = 20);
      group E) 40 W x 5 seconds with visual inspection (blanch, swells, collapse) (n =
      16); group F) 50 W x 5 seconds (n = 8). Bipolar electrocoagulation was performed
      in groups A to E, and monopolar electrocoagulation was performed in group F.
      Coagulation mode was used in all groups. Digital photomicrography of the
      transversal histological sections of the isthmic segment of the Fallopian tube
      were taken, and the median percentage of unobstructed luminal area (mm2) was
      measured with ImageJ software (ImageJ, National Institutes of Health, Bethesda,
      MD, USA). The Kruskal-Wallis test or analysis of variance (ANOVA) was used for
      statistical analysis. RESULTS:  Ninety-six Fallopian tube sections were analyzed.
      The smallest median occluded area (%; range) of the Fallopian tube was obtained
      in the group with 40 W with visual inspection (8.3%; 0.9-40%), followed by the
      groups 25 W (9.1%; 0-35.9%), 40 W (14.2; 0.9-43.2%), 30 W (14.2; 0.9-49.7%), 35 W
      (15.1; 3-46.4%) and 50 W (38.2; 3.1-51%). No statistically significant difference
      was found among groups (p = 0.09, Kruskal-Wallis test). CONCLUSION:  The smallest
      unobstructed area was obtained with power setting at 40 W with visual inspection
      using a modern electrosurgical generator. However, no statistically significant
      difference in the unobstructed area was observed among the groups using these
      different modes and potencies.

PMID- 29843173
TI  - Diagnosis and Treatment of Pulmonary Embolism in Challenging Populations.
AB  - Although the diagnostic and therapeutic approach to pulmonary embolism (PE) has
      been considerably improved and standardized in recent years, special populations
      such as pregnant patients and those with impaired renal function or cancer still
      represent a clinical challenge and a detailed knowledge about the available
      diagnostic and therapeutic alternatives is mandatory to provide best evidence
      based care for these difficult-to-treat patients. Although this review aimed to
      summarize the most important aspects in this field, the reader is referred to the
      original studies cited here and dedicated guideline and guidance documents for
      more detailed information.

PMID- 29843172
TI  - Initial and Long-Term Treatment of Pulmonary Embolism: Current Approach and
      Future Perspectives.
AB  - Pulmonary embolism is associated with variable risk of early mortality, ranging
      from less than 1% to more than 15%. Risk stratification, based on clinical
      variables and signs of right ventricular dysfunction, is crucial to decide the
      best management and treatment strategy. Home therapy may be an option for low
      risk patients, whereas patients at intermediate risk need to be hospitalized and
      some of them, at intermediate high risk, may require more intensive monitoring to
      early detect signs of haemodynamic decompensation. The initial treatment is based
      on anticoagulants with rapid onset of action, either parenteral
      (heparin/fondaparinux) or oral (direct oral anticoagulants, DOACs). Thereafter,
      DOACs (or, if contraindicated, vitamin K antagonists) needs to be continued for
      at least 3 months. Beyond this period, an individual re-evaluation of the risk-to
      benefit ratio of anticoagulation should be performed, based on several factors,
      including the type of index event, age, sex, D-dimer and residual venous
      obstruction. Possibly safer strategies can be offered to higher risk patients
      requiring extended duration of treatment, including the DOACs apixaban and
      rivaroxaban at reduced dose.

PMID- 29843174
TI  - Reperfusion Treatment for Acute Pulmonary Embolism.
AB  - Due to the manifold treatment options for the management of acute pulmonary
      embolism, state-of-the-art management requires risk stratification for choosing
      the adapted treatment for each patient. Reperfusion therapy is an integral part
      of therapy for patients with pulmonary embolism at high risk for mortality, but
      its role in patients with intermediate risk pulmonary embolism is more debated.
      The largest amount of evidence exists for systemic thrombolysis, which is an
      efficient therapy, but at the prize of an increased bleeding risk. In recent
      years, various types of catheter-based reperfusion therapies have been
      introduced, and evidence is growing that this therapy is as efficient as systemic
      thrombolysis, but with a more favourable safety profile. Surgical embolectomy
      remains a good alternative for unstable patients, especially for those with
      absolute contraindications for thrombolysis or after failed systemic
      thrombolysis. While the early benefits of reperfusion therapy are well
      documented, evidence for long-term benefit is still scarce. The scope of this
      review is to summarize the evidence for the currently available reperfusion
      therapies in the management of acute pulmonary embolism.

PMID- 29843175
TI  - [Emergency Neurology].

PMID- 29843176
TI  - [Acute unconsciousness].
AB  - Emergency treatment of unconscious patients is a complex task and should follow a
      standardised algorithm. Stabilisation of vital parameters, diagnostic procedures,
      and therapeutic interventions should be carried out in part simultaneously and
      require interdisciplinary teamwork. Diagnosis has to be made under high time
      pressure in order to recognize life threatening causes and initiate specific
      treatments. Often, the earlier the treatment starts, the better the outcome is.

PMID- 29843177
TI  - [Status epilepticus].
AB  - Status epilepticus is a neurologic emergency manifested by prolonged seizure
      activity or multiple seizures without full recovery of previous condition in
      between. The most important aim of treatment is early seizure termination,
      because duration of status epilepticus correlates with a higher rate of morbidity
      and mortality. Based on evidence from clinical trials and guidelines strategies
      for management of status epilepticus are provided.

PMID- 29843178
TI  - [Meningism].
AB  - A thorough neurological examination in emergency situations requires the
      evaluation of meningeal signs. Even though in most settings, evaluation of
      meningism is technically not very demanding, the interpretation of findings may
      prove difficult. As opposed to a widely held belief, clinical signs of meningism
      are neither specific nor highly sensitive for detection of meningitis or
      subarachnoid hemorrhage. A meaningful evaluation of meningeal signs, therefore,
      requires careful consideration of both clinical findings and other accessory
      symptoms.

PMID- 29843179
TI  - [Myasthenic Crisis].
AB  - Myasthenic crisis is the life threatening maximal manifestation of myasthenia
      gravis. Severe dysphagia and respiratory insufficiency demand admission to an
      intensive care unit (ICU). At variance, the timely recognition and treatment of
      myasthenic exacerbation may prevent a manifesting crisis. This reviews deals with
      red flags that pronounce exacerbation and crisis. Myasthenic crisis is an
      important differential diagnosis of bulbar symptoms and dysphagia. We elaborate
      on a structured and comprehensive approach to myasthenic crisis on the ICU.
      Hallmarks of therapy are symptomatic treatment with acetylcholine esterase
      inhibitors, plasmapheresis or immunoadsorption, polyvalent immunoglobulins, an
      early start of steroids and immunosuppressants, namely azathioprine, and a
      consequent escalation to monoclonal antibody therapy, with rituximab being the
      first choice. Special demands in ICU treatments are a structured weaning concept,
      consequent treatment of comorbidities and complications, first and foremost
      infections, dysphagia management, and comprehensive prevention and treatments of
      delirium.

PMID- 29843180
TI  - [Circadian rhythms and depression].
AB  - Depressive disorders are associated with various neurobiological alterations like
      hyperactivity of the hypothalamic-pituitary-adrenal axis, altered neuroplasticity
      and altered circadian rhythms. Relating to the circadian symptoms, a process is
      adopted in which individual genetic factors together with social, psychological
      and physical stressors may lead to a decompensation of the circadian system. The
      causal connections between depressive disorders and disturbed circadian rhythms
      have not been completely clarified. Chronobiological therapy is based on these
      disturbed processes. For the treatment of the circadian symptoms, various
      scientifically tested chronotherapeutics are available with however different
      effectiveness and evidence like light therapy or sleep deprivation. The
      successful treatment of depression also frequently leads to a improvement in
      altered circadian rhythm.

PMID- 29843181
TI  - De Novo Transcriptome Assembly and Characterization of Lithospermum officinale to
      Discover Putative Genes Involved in Specialized Metabolites Biosynthesis.
AB  - Lithospermum officinale is a valuable source of bioactive metabolites with
      medicinal and industrial values. However, little is known about genes involved in
      the biosynthesis of these metabolites, primarily due to the lack of genome or
      transcriptome resources. This study presents the first effort to establish and
      characterize de novo transcriptome assembly resource for L. officinale and
      expression analysis for three of its tissues, namely leaf, stem, and root. Using
      over 4Gbps of RNA-sequencing datasets, we obtained de novo transcriptome assembly
      of L. officinale, consisting of 77,047 unigenes with assembly N50 value as 1524
      bps. Based on transcriptome annotation and functional classification, 52,766
      unigenes were assigned with putative genes functions, gene ontology terms, and
      Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. KEGG pathway and gene
      ontology enrichment analysis using highly expressed unigenes across three tissues
      and targeted metabolome analysis showed active secondary metabolic processes
      enriched specifically in the root of L. officinale. Using co-expression analysis,
      we also identified 20 and 48 unigenes representing different enzymes of
      lithospermic/chlorogenic acid and shikonin biosynthesis pathways, respectively.
      We further identified 15 candidate unigenes annotated as cytochrome P450 with the
      highest expression in the root of L. officinale as novel genes with a role in key
      biochemical reactions toward shikonin biosynthesis. Thus, through this study, we
      not only generated a high-quality genomic resource for L. officinale but also
      propose candidate genes to be involved in shikonin biosynthesis pathways for
      further functional characterization.

PMID- 29843182
TI  - A Cyclotide Isolated from Noisettia orchidiflora (Violaceae).
AB  - Biologically active cyclotides have been found on some flowering plants species
      and are involved in the role of the plant protection. As part of studies focusing
      on peptides from Brazilian plant species, we are reporting the detection by LC-MS
      of several cyclotides from leaves and stems of Noisettia orchidiflora
      (Violaceae). From stems it was possible to isolate and characterize a cyclotide
      named Nor A. Its primary structure (amino acid sequence) was established by MALDI
      TOF-MS, based on the y- and b-type ion series, after reduction and alkylation
      reactions, as well as enzymatic digestion using the enzymes endoproteinase
      glutamic acid (endoGlu-C), trypsin, and chymotrypsin. Furthermore, the amino acid
      analysis was also described.

PMID- 29843183
TI  - The Integration of Metabolomics and Next-Generation Sequencing Data to Elucidate
      the Pathways of Natural Product Metabolism in Medicinal Plants.
AB  - Plants have always been used as medicines since ancient times to treat diseases.
      The knowledge around the active components of herbal preparations has remained
      nevertheless fragmentary: the biosynthetic pathways of many secondary metabolites
      of pharmacological importance have been clarified only in a few species, while
      the chemodiversity present in many medicinal plants has remained largely
      unexplored. Despite the advancements of synthetic biology for production of
      medicinal compounds in heterologous hosts, the native plant species are often the
      most reliable and economic source for their production. It thus becomes
      fundamental to investigate the metabolic composition of medicinal plants to
      characterize their natural metabolic diversity and to define the biosynthetic
      routes in planta of important compounds to develop strategies to further increase
      their content. We present here a number of case studies for selected classes of
      secondary metabolites and we review their health benefits and the historical
      developments in their structural elucidation and characterization of biosynthetic
      genes. We cover the cases of benzoisoquinoline and monoterpenoid indole
      alkaloids, cannabinoids, caffeine, ginsenosides, withanolides, artemisinin, and
      taxol; we show how the "early" biochemical or the more recent integrative
      approaches-based on omics-analyses-have helped to elucidate their metabolic
      pathways and cellular compartmentation. We also summarize how the knowledge
      generated about their biosynthesis has been used to develop metabolic engineering
      strategies in heterologous and native hosts. We conclude that following the
      advent of novel, high-throughput and cost-effective analytical technologies, the
      secondary metabolism of medicinal plants can now be examined under the lens of
      systems biology.

PMID- 29843184
TI  - [Spinal cord injury with neurogenic lower urinary tract dysfunction as a
      potential risk factor for bladder carcinoma].
AB  - INTRODUCTION AND OBJECTIVES:  Life expectancy for people with spinal cord
      injury/disease (SCI/D) is increasing, due to modern advances in treatment methods
      and in neuro-urology. However, with the increased life expectancy the risk of
      developing urinary bladder cancer is gaining importance. How is this patient
      group different from the general population? METHODS:  Single-centre
      retrospective evaluation of consecutive patient data with spinal cord injury and
      proven urinary bladder cancer. RESULTS:  Between January 1st 1998 and March 31st
      2017, 32 (3 female, 29 male) out of a total of 6432 patients with SCI/D were
      diagnosed with bladder cancer.The average age at bladder cancer diagnosis was
      54.5 years, which is well below the average for bladder cancer cases in the
      general population (male: 74, female: 75).Twenty-seven patients suffered from
      urodynamically confirmed neurogenic detrusor overactivity, while five patients
      (all male) had detrusor acontractility.The median latency period between the
      onset of SCI/D and tumor diagnosis was 29.5 years. Temporary indwelling
      catheterisation was found in four patients for only 1.61 % of the overall latency
      period of all patients.The majority of the patients (n = 27) had transitional
      cell carcinoma, while five had squamous cell carcinoma. Of the 32 patients, 25
      (78 %) had muscle invasive bladder cancer at >= T2 at the time of diagnosis.
      Regarding tumour grading, 23 out of 32 patients showed a histologically poorly
      differentiated G3 carcinoma; two patients each had G2 and G1 tumours repectively
      (no information on tumour grading was available in five patients).The median
      survival for all patients was 11.5 months. The prognosis of patients with
      squamous cell carcinoma was even worse; 4 out of 5 died within 7 months (median 4
      months). CONCLUSIONS:  The significantly younger age at onset and the frequency
      of invasive, poorly differentiated tumour at diagnosis indicate that SCI/D
      influences both bladder cancer risk and prognosis significantly. The latency
      period between paralysis and tumour disease seems to be a decisive risk
      parameter.The type of neurogenic bladder dysfunction and the form of bladder
      drainage do not appear to influence the risk. Long-term indwelling catheter
      drainage played only a minor role in the investigated patients.Early detection of
      bladder cancer in patients with spinal cord injury remains a challenge.

PMID- 29843185
TI  - Off-Pump Coronary Artery Bypass Graft Versus Drug-Eluting Stent Implantation in
      Patients with Multivessel Disease Involving the Right Coronary Artery.
AB  - BACKGROUND:  Whether percutaneous coronary intervention (PCI) is superior to
      coronary artery bypass grafting (CABG) for the right coronary territory is
      unknown. The aim of this study was to compare the outcomes and patency in the
      right coronary territory after CABG or PCI. METHODS:  We studied 2,467
      multivessel coronary artery disease patients from January 2001 to December 2011;
      1,672 were off-pump CABG patients and 795 were PCI. The graft patency and the
      presence of major adverse cardiac and cerebrovascular events (MACCEs) including
      death, myocardial infarction, target vessel revascularization, and stroke were
      analyzed. RESULTS:  After propensity score matching, cardiac-related survival was
      found to be significantly higher in the CABG group than in the PCI group (hazard
      ratio (HR) for the PCI group: 2.445, p = 0.006). The PCI group showed higher
      rates of myocardial infarction (HR: 2.571, p = 0.011) and target vessel
      revascularization (HR: 3.337, p < 0.001). In the right coronary territory, the
      right internal thoracic artery patency was not different in the PCI group
      compared with the CABG group (p = 0.248). In CABG group, low right coronary
      artery graft patency was associated with cardiac-related death (HR: 0.17, p =
      0.003) and the occurrence of MACCEs (HR: 0.22, p < 0.001). CONCLUSION:  CABG was
      superior to PCI in patients with multivessel disease. Low graft patency in the
      right coronary territory was associated with cardiac-related death and the
      occurrence of MACCEs.

PMID- 29843186
TI  - Predictive Factors of Thoracic Lymph Node Metastasis Accompanying Pulmonary
      Metastasis from Colorectal Cancer.
AB  - BACKGROUND:  The aim of this study was to identify the factors predicting
      thoracic lymph node (LN) metastases for pulmonary resection from colorectal
      cancer (CRC). METHODS:  The records of 160 patients who underwent pulmonary
      metastasectomy for CRC were retrospectively reviewed. Clinicopathologic factors
      were analyzed with chi-square test or t-test and logistic regression to identify
      predictable factors for LN metastases. RESULTS:  Sixty patients (37.5%) underwent
      LN dissection during pulmonary metastasectomy, and LN metastases were found in
      five patients. Twenty-three patients had LN recurrence among the 100 patients
      (62.5%) without LN dissection during the follow-up period. Twenty-eight patients
      out of 160 (17.5%) had LN metastases. By multivariate analysis, the number of
      pulmonary metastasis and metastasis from colon cancers were independent factors
      predicting LN metastases. CONCLUSION:  The number of pulmonary metastasis and
      metastasis from colon cancers were independent factors predicting LN metastases.
      LN sampling should be performed especially in cases with strong predictive
      factors to improve staging and help guide further treatment.

PMID- 29843187
TI  - Comparing Part-Solid and Pure-Solid Tumors in the TNM Classification of Lung
      Cancer (Eighth Edition).
AB  - BACKGROUND:  In the eighth edition of the TNM classification, the lung tumors
      that have the same solid components are categorized either as part-solid or pure
      solid tumors. However, this is debatable since the tumors in the same T component
      categories were evaluated without considering this categorization, and was based
      on a more malignant behavior and a poorer prognosis of pure-solid tumors. The aim
      of this study was to investigate and compare the prognosis between part-solid and
      pure-solid tumors. METHODS:  We retrospectively analyzed 530 patients who were
      diagnosed with clinical-T1a-cN0M0 non-small-cell lung cancer (NSCLC) and were
      treated surgically. The subjects were divided into part-solid and pure-solid
      tumor groups using thin-section computed tomography. The prognosis was compared
      between the groups. RESULTS:  Although relapse-free survival (RFS) was
      significantly shorter in the pure-solid tumor group (p = 0.016), no significant
      differences were observed in the overall survival (OS) between the two groups (p
      = 0.247). In 137 propensity score-matched pairs, including variables such as age,
      gender, Brinkman index, body mass index, forced expiratory volume in 1
      second/forced vital capacity, Charlson comorbidity index, carcinoembryonic
      antigen levels, clinical-T status, surgical procedure, and extent of surgery, no
      significant differences were seen in the RFS and OS between the two groups (p =
      0.709 and p = 0.517, respectively). CONCLUSION:  In the eighth edition of the TNM
      classification of clinical-T1a-cN0M0 NSCLC, the prognosis of part-solid and pure
      solid tumors showed no significant differences. Solid component size of the tumor
      is considered important prognostic factor in early-stage NSCLC.

PMID- 29843188
TI  - Fear of cancer recurrence and death anxiety.
AB  - In 2013, 3 systematic reviews of fear of cancer recurrence (FCR) and its
      predictors were published. All 3 concurred that FCR is a highly prevalent problem
      and amongst the largest unmet needs of cancer survivors, even 5 or more years
      after treatment. However, between them they identified only 1 study that had
      investigated the relationship between death anxiety and FCR. This is surprising
      because it is well acknowledged that a diagnosis of cancer, a potentially life
      threatening illness, is associated with a number of existential issues that give
      rise to psychological sequelae such as intrusive thoughts about death and other
      post-traumatic symptoms. Outside the cancer literature, there has recently been a
      call to identify death anxiety as a transdiagnostic construct that underlies many
      anxiety disorders even in healthy people. And yet, the relevance of death anxiety
      to FCR has not been studied. We explore the barriers to the study of death
      anxiety and FCR and the reasons that a potential link between the 2 might have
      important theoretical and clinical implications. We conclude that establishing
      the relationship between death anxiety, FCR and other existential issues is
      essential in order to fully understand FCR, particularly in the context of
      advanced disease. We further conclude that whether death anxiety underlies FCR
      has important clinical implications which would potentially allow us to optimise
      currently available evidence-based treatments.

PMID- 29843189
TI  - Re-validation and screening capacity of the 6-item version of the Cancer Worry
      Scale.
AB  - OBJECTIVE: Fear of cancer recurrence (FCR) is one of the major existential unmet
      needs of cancer survivors. Due to growing availability of evidenced-based
      interventions for high FCR, valid and reliable brief measures of FCR are needed.
      This study aimed to validate the 6-item Cancer Worry Scale (CWS) and to establish
      a cut-off score for high FCR. METHODS: Participants in this study were 1033
      cancer survivors and patients recruited as part of 5 existing studies on FCR
      involving patients and survivors with gastro-intestinal stromal tumors,
      colorectal, breast, and prostate cancer. De-identified data of the CWS, Fear of
      Cancer Recurrence Inventory (FCRI), Impact of Event Scale, Hospital Anxiety and
      Depression Scale, and EORTC-QLQ-C30 were amalgamated for the analyses.
      Confirmatory factor analysis of the CWS was performed. Sensitivity and
      specificity were tested with the FCRI as gold standard. RESULTS: Results
      confirmed that the 6-item version of the CWS maintained good construct validity,
      convergent and divergent validity, and high internal consistency (alpha 0.90).
      The optimal cut-off for the 6-item CWS was 9 versus 10 using the 12 vs 13 FCRI-SF
      score (sensitivity 82%, specificity 83%) and the 15 vs 16 FCRI-SF score
      (sensitivity 88%, specificity 73%). Using the highest FCRI-SF cut-off (21 vs 22),
      the optimal CWS cut-off was 11 vs 12 (sensitivity 88%, specificity 81%).
      CONCLUSIONS: The present results provide researchers and clinicians with a brief
      valid and reliable measure of FCR which is suitable for measuring FCR in cancer
      patients and survivors.

PMID- 29843191
TI  - "Spirituality" hardly facilitates our understanding of existential distress-But
      "everyday life" might.

PMID- 29843190
TI  - The relationship between cancer-related worry and posttraumatic growth in
      adolescent and young adult cancer survivors.
AB  - OBJECTIVES: To examine cancer-related worry in adolescent and young adult (AYA)
      cancer survivors and its relationship with posttraumatic growth over time, as the
      relationship between these constructs has not been assessed longitudinally in
      this population. METHODS: A total of 153 AYA cancer survivors completed measures
      of cancer-related worry and posttraumatic growth 3 times across approximately 1
      year. Descriptive statistics were calculated for cancer-related worry items, and
      mixed-effects modeling assessed the relationship between cancer-related worry and
      posttraumatic growth. RESULTS: Most participants reported at least moderate
      cancer-related worry in at least 1 area at each assessment (88.2-93.9% across
      time points). Worry about future health was the most prevalent concern (65.4%
      83.7% across time points). Cancer-related worry was positively related to
      posttraumatic growth in the mixed-effects model. However, post hoc analyses
      indicated that cancer-related worry and posttraumatic growth were modestly
      related; there was no evidence that either construct predicted the other over
      time. CONCLUSIONS: Cancer-related worry appears to be a common psychosocial
      outcome in AYA cancer survivors. However, cancer-related worry appears to be only
      modestly related to the development of posttraumatic growth, implying that these
      may be independent constructs despite theoretical literature suggesting that
      posttraumatic growth may stem from posttraumatic distress. Thus, it is necessary
      to assess AYA survivors for cancer-related worry and posttraumatic growth, and
      develop interventions to target cancer-related worry and foster posttraumatic
      growth.

PMID- 29843192
TI  - CD73, CD90, CD105 and Cadherin-11 RT-PCR Screening for Mesenchymal Stem Cells
      from Cryopreserved Human Cord Tissue.
AB  - Background and Objectives: Mesenchymal stem cells (MSCs) are self-renewing, non
      specialized cells used clinically in tissue regeneration and sourced from bone
      marrow, peripheral blood, umbilical cord blood and umbilical cord tissue (UCT).
      To demonstrate an alternative method for MSC detection, cryopreserved UCT and
      expanded MSC were screened for MSC markers CD73, CD90, CD105 and CDH-11 by RT
      PCR. Methods and Results: Human UCT were washed, sectioned, cryopreserved with
      10% DMSO and stored in the vapor phase of liquid nitrogen. Fresh and frozen UCT
      samples were expanded for MSC. UCT and MSC were processed for RNA and screened
      for CD73, CD90, CD105 and CDH-11 mRNA by RT-PCR. CD73, CD90 and CD105 were
      detected by flow cytometry and CDH-11 was detected by Western blotting. Short and
      long-term frozen UCT shows a loss of mRNA expression for CD73 at 33.2+/-34.0%,
      CD90 at 6.2+/-8.2%, CD105 at 17.7+/-21.6% and CDH-11 at 30.1+/-26.7% but was not
      statistically significant to indicate the deterioration. Expanded MSCs from fresh
      UCT expressed 0.09+/-0.07-fold CD73, 0.17+/-0.11-fold CD90, 0.04+/-0.06-fold
      CD105 and 0.14+/-0.08-fold CDH-11. Expanded MSCs from frozen UCTs expressed
      0.09+/-0.06-fold CD73, 0.13+/-0.06-fold CD90, 0.04+/-0.05-fold CD105 and 0.11+/
      0.06-fold CDH-11 and confirmed by flow cytometry and Western blotting.
      Conclusion: CD73, CD90, CD105 and CDH-11 were detected by RT-PCR in cryopreserved
      UCT and MSC expansion. CDH-11 appears as a useful single target MSC marker for
      quick screening.

PMID- 29843193
TI  - Large-scale Isolation, Expansion and Characterization of Human Amniotic
      Epithelial Cells.
AB  - Background and Objectives: The human Amniotic epithelial cells (AME) derived from
      amniotic membrane of placenta have been considered as the potential fetal stem
      cell source with minimal or no ethical concerns and are important therapeutic
      tool for anti-fibrotic and regenerative therapies. Methods and Results: Here, we
      evaluated the isolation, media screening, scale-up and characterization of AME
      cells. The isolation, expansion of AMEs were performed by sequential passaging
      and growth kinetics studies. The AMEs were characterized using
      immunocytochemistry, immunophenotyping, In-vitro differentiation, and anti
      fibrotic assays. The growth kinetics study revealed that the AME cultured in
      Ultraculture (UC) and DMEM knockout (DMEM-KO) have prominently higher growth rate
      compared to others. Overall, the AMEs cultured from 5 different media retained
      basic morphological characteristics and the functional characteristics.
      Conclusions: Our result suggests that the AMEs can be successfully cultured in UC
      based complete media without losing its epithelial cell characteristics even
      after passaging for passage 2 (P2). However, a careful and methodical pre
      clinical and clinical translation studies need to be conducted to show its safety
      and efficacy.

PMID- 29843194
TI  - The Role of Microenvironment in Preserving the Potency of Adult Porcine Pulmonary
      Valve Stem Cells In Vitro.
AB  - Background and Objective: The potency of tissue resident stem cells is regulated
      primarily by inputs from the local microenvironment. Isolation of stem cells
      through enzymatic digestion of tissue may affect epigenetic regulation of cell
      fate and performance. Here we employ a non-enzymatic method to harvest and
      investigate tissue resident stem cells from the adult porcine pulmonary valve.
      Methods and Results: The presence of c-Kit+ stem cells within the valve tissue
      was confirmed by immunohistochemistry. An in vitro culture of minced valve
      leaflets was developed under the standard conditions (37 degrees C with 5% CO2).
      The viability of the cellular outgrowths was evaluated over the subsequent 12
      weeks. Under this culture condition, we identified a population of non-adherent c
      Kit+ cells and multiple cellular structures mimicking the phenotype of embryonic
      stem cells at different stages of development. Formation of multinucleated cells
      through cell fusion provided an active niche area for homing and interaction of
      the non-adherent c-Kit+ cells. Expression of pluripotency markers Oct-4 and Nanog
      was detected in the newly formed multinucleated cells but not in mature colonies.
      Partial cell fusion was shown by fluorescent live-cell tracking, which confirmed
      intercellular molecular exchange between donor and recipient cells, resulting in
      altered cytoplasmic protein expression by the recipient cell. Conclusions: These
      results suggest a role for the microenvironment in decrypting the potential of
      the valve somatic stem cells in vitro. In addition, our data provide evidence for
      cell fusion, which may play a critical role in reversing somatic cell fate and
      spontaneous cellular reprogramming.

PMID- 29843195
TI  - Anterior Cruciate Ligament Reconstruction: The Long Road from Science to Clinical
      Relevance.

PMID- 29843196
TI  - A Comparison of Results after Anterior Cruciate Ligament Reconstruction in over
      40 and under 40 Years of Age: A Meta-Analysis.
AB  - Purpose: Anterior cruciate ligament (ACL) injury is one of the most common
      injuries that occur in the knee, and ACL reconstruction (ACLR) is commonly
      performed for preventing aggravation of degenerative changes and restoring of
      knee stability in young, athletic patients. This meta-analysis has a purpose of
      evaluating the clinical and arthrometrical outcomes of ACLR in a group of middle
      age patients (40 years and older) and comparing with patients under 40 years of
      age. Methods: MEDLINE, EMBASE, the Cochrane Central Register of Controlled
      Trials, Web of Science, and SCOPUS electronic databases were searched for
      relevant articles comparing the outcomes of ACLR between younger and older than
      40 years of age until December 2016. Data searching, extraction, analysis, and
      quality assessment were performed based on the Cochrane Collaboration guidelines.
      Clinical outcomes were evaluated and compared between groups. The results were
      presented as mean difference for continuous outcomes with 95% confidence
      intervals whereas risk ratio for binary outcomes. Results: Seven studies were
      included in the meta-analysis. Based on International Knee Documentation
      Committee classification, side-to-side difference, Tegner activity score, Lysholm
      knee score, there were no significant clinical and mechanical differences between
      the groups. Conclusions: This meta-analysis confirmed that after ACLR, middle age
      (>40 years) and young age (<40 years) patients did not present with significant
      difference in clinical and arthrometric results.

PMID- 29843197
TI  - Two-Stage Reimplantation in Infected Total Knee Arthroplasty.
AB  - Two-stage reimplantation is considered the gold standard for the management of
      periprosthetic joint infection. The first stage involves the removal of the
      prosthesis, followed by extensive debridement of all nonviable tissues,
      synovectomy, irrigation, and reaming of the medullary canals. Once the joint has
      been prepared, antibiotic-impregnated cement beads and/or spacer are inserted.
      Antibiotic-impregnated spacers are now more commonly used, and an increasing
      number of orthopaedic surgeons are using articulating spacers if indicated.
      Antibiotics are then prescribed to the patient based on the sensitivities of the
      infecting organism. The duration of systemic antibiotic use is decreasing, and
      short courses of antibiotic therapy have been shown to be as efficacious as
      prolonged therapy between the first and second stages. The second stage of the
      procedure involves removal of the antibiotic-impregnated cement beads and/or
      spacer, repeat irrigation and debridement, and final reconstruction with revision
      components. While two-stage reimplantation was considered the gold standard in
      many parts of the world, recent studies have demonstrated that it is associated
      with a considerable failure rate. This may be due to the lack of accurate
      diagnostic tools for infection eradication, and future investigation of risk
      factors for failure of the two-stage reimplantation should be conducted.

PMID- 29843198
TI  - Intraoperative Graft Isometry in Anatomic Single-Bundle Anterior Cruciate
      Ligament Reconstruction.
AB  - Purpose: Little is known about the isometry of anatomic single-bundle anterior
      cruciate ligament (ACL) tunnel positions in vivo although it is closely related
      to graft tension throughout the range of motion. The purpose of this study was to
      evaluate intraoperative graft isometry in anatomic single-bundle ACL
      reconstruction in vivo. Materials and Methods: Graft length changes were assessed
      before bio-screw fixation in the tibial tunnel by pulling the graft with tensions
      of 20 lbs and 30 lbs in full extension at flexion angles of 30 degrees , 60
      degrees , 90 degrees , and 120 degrees . Results: At the flexion angle of 30
      degrees , 20 lbs and 30 lbs of tension showed -0.4 mm and -0.6 mm length changes,
      respectively. The greater the flexion angle of the knee, the shorter the graft
      length in the joint. At the flexion angles of 90 degrees  and 120 degrees , there
      was significant difference in the graft length change between 20 lbs and 30 lbs
      of tension. Conclusions: Anatomic single-bundle ACL reconstruction was non
      isometric. The graft length was the longest in full extension. The tension of
      graft became loose in flexion. At the flexion angles of 90 degrees  and 120
      degrees , there was significant difference in the graft length change between 20
      lbs and 30 lbs of tension.

PMID- 29843199
TI  - Does Adductor Canal Block Have a Synergistic Effect with Local Infiltration
      Analgesia for Enhancing Ambulation and Improving Analgesia after Total Knee
      Arthroplasty?
AB  - Purpose: We compared a single-injection adductor canal block (ACB) with or
      without local infiltration analgesia (LIA) for accelerating functional recovery
      and reducing postoperative pain after total knee arthroplasty (TKA). Materials
      and Methods: Sixty-two patients undergoing TKA with simple spinal analgesia and
      ACB were randomized to receive either LIA (group A+L) or placebo LIA (group A).
      Postoperative visual analog scale (VAS) score for pain, Timed Up and Go (TUG)
      test and quadriceps strength, total dosage of rescue analgesia, time to first
      rescue analgesia, and adverse events were serially evaluated from postoperative
      day 1 to 3 months. Results: There were no differences between both groups in pre-
      and postoperative VAS, TUG test, quadriceps strength 2 days, 3 days, 2 weeks, 6
      weeks, and 3 months postoperatively. There were no differences in Knee Society
      clinical and function scores at 6 months and 1 year. However, group A+L had a
      significantly longer time for postoperative rescue analgesia (491 minutes vs. 143
      minutes, p=0.04) with less patients requiring rescue analgesia during 6 hours
      after surgery (16.7% vs. 43.3%, p=0.024). Both groups had similarly high rates of
      patient satisfaction with low adverse event rates. Conclusions: Combined ACB and
      LIA in TKA enhanced early ambulation with reduced and delayed rescue analgesia.

PMID- 29843200
TI  - Safety and Efficacy of 6.2 mm Patellar Button in Resurfacing Less than 20 mm Thin
      Patella: A Matched Pair Analysis.
AB  - Purpose: Restoring the native patellar thickness after patellar resurfacing
      provides optimal function of the knee after arthroplasty and minimises
      complications related to the patellofemoral articulation. The aim of this study
      was to assess the usefulness of a thin patellar button (6.2 mm) in patients with
      a patella thickness of less than 20 mm during total knee arthroplasty. Materials
      and Methods: This is a retrospective case control study. A total of 54 female
      patients with an intraoperative patellar thickness of <20 mm, resurfaced with a
      patellar button of 6.2 mm in thickness were identified (group 1). They were
      matched with 54 patients with a patellar thickness of 20-23 mm, resurfaced with a
      patellar button of 8 mm (group 2), based on age, sex, body mass index, and
      deformity. A clinical and radiological evaluation was done at a minimum 2-year
      follow-up. Results: The preoperative mean patellar thickness was 18.94+/-1.07 mm
      and was restored to 19.06+/-0.79 mm in group 1, as compared to 21.63+/-0.99 mm
      and 21.72+/-0.99 mm in group 2. The mean postoperative range of motion was 122.22
      degrees +/-9.25 degrees  in group 1 and 123.52 degrees +/-8.72 degrees  in group
      2 (p=0.13). No patellar bone or button related complications were observed in any
      patient in either group. Conclusions: The 6.2 mm thin patella is useful to
      restore the native thickness in patients with a patellar thickness of less than
      20 mm without risk of button fracture, loosening or overstuffing.

PMID- 29843201
TI  - Comparison of Revision Rates Due to Aseptic Loosening between High-Flex and
      Conventional Knee Prostheses.
AB  - Purpose: The purpose was to evaluate and compare the revision rate due to aseptic
      loosening between a high-flex prosthesis and a conventional prosthesis. Materials
      and Methods: Two thousand seventy-eight knees (1,377 patients) with at least 2
      years of follow-up after total knee arthroplasty were reviewed. Two types of
      implants were selected (LPS-Flex and LPS, Zimmer) to compare revision and
      survival rates and sites of loosened prosthesis component. Results: The revision
      rate of the LPS-Flex (4.9%) was significantly higher than that of the
      conventional prosthesis (0.6%) (p<0.001). The 5-, 10-, and 15-year survival rates
      were 98.9%, 96.2% and 92.0%, respectively, for the LPS-Flex and 99.8%, 98.5% and
      93.5%, respectively, for the LPS. The survival rate of the high-flex prosthesis
      was significantly lower than that of the conventional prosthesis, especially in
      the mid-term period (range, 5 to 10 years; p=0.002). The loosening rate of the
      femoral component was significantly higher in the LPS-Flex prosthesis (p=0.001).
      Conclusions: The LPS-Flex had a higher revision rate due to aseptic loosening
      than the LPS prosthesis in the large population series with a long follow-up. The
      LPS-Flex should be used carefully considering the risk of femoral component
      aseptic loosening in the mid-term (range, 5 to 10 years) follow-up period after
      initial operation.

PMID- 29843203
TI  - Comparison of priming versus slow injection for reducing etomidate-induced
      myoclonus: a randomized controlled study.
AB  - Background: Etomidate injection is often associated with myoclonus. Etomidate
      injection technique influences the incidence of myoclonus. This study was
      designed to clarify which of the two injection techniques-slow injection or
      priming with etomidate-is more effective in reducing myoclonus. Methods: This
      prospective randomized controlled study was conducted on 189 surgical patients
      allocated to three study groups. Control group (Group C, n = 63) received 0.3
      mg/kg etomidate (induction dose) over 20 s. Priming group (Group P, n = 63)
      received pretreatment with 0.03 mg/kg etomidate, followed after 1 min by an
      etomidate induction dose over 20 s. Slow injection group (Group S, n = 63)
      received etomidate (2 mg/ml) induction dose over 2 min. The patients were
      observed for occurrence and severity of myoclonus for 3 min from the start of
      injection of the induction dose. Results: The incidence of myoclonus in Group P
      (38/63 patients [60.3%], 95% CI [48-71.5%]) was significantly lower than in Group
      C (53/63 patients [84.1%], 95% CI [72.9-91.3%], P = 0.003) and Group S (49/63
      patients [77.8%], 95% CI [66-86.4%], P = 0.034). Myoclonus of moderate or severe
      grade occurred in significantly more patients in Group C (68.3%) than in Group P
      (36.5%, P < 0.001) and Group S (50.8%, P = 0.046), but the difference between
      Groups P and S was not significant (P = 0.106). Conclusions: Priming is more
      effective than slow injection in reducing the incidence of myoclonus, but their
      effects on the severity of myoclonus are comparable.

PMID- 29843202
TI  - The effect of magnesium sulfate concentration on the effective concentration of
      rocuronium, and sugammadex-mediated reversal, in isolated left phrenic nerve hemi
      diaphragm preparations from the rat.
AB  - BACKGROUND: Perioperative magnesium sulfate (MgSO4) is used for analgesic, anti
      arrhythmic, and obstetric purposes. The effects of MgSO4 on the neuromuscular
      blockade (NMB) induced by rocuronium, and the sugammadex reversal thereof, have
      not been clearly quantified. We investigated the effect of various MgSO4
      concentrations on the NMB by rocuronium, and sugammadex reversal, in isolated
      left phrenic nerve hemi-diaphragm (PNHD) preparations from the rat. METHODS: Rat
      PNHD preparations were randomly allocated to one of four groups varying in terms
      of MgSO4 concentration (1, 2, 3, and 4 mM, each n = 10, in Krebs solution). The
      train-of-four (TOF) and twitch height responses were recorded
      mechanomyographically. The preparations were treated with incrementally
      increasing doses of rocuronium and each group's effective concentration (EC)50,
      EC90, and EC95 of rocuronium were calculated via nonlinear regression. Then,
      sugammadex was administered in doses equimolar to rocuronium. The recovery index,
      time to T1 height > 95% of control, and the time to a TOF ratio > 0.9 after
      sugammadex administration were measured. RESULTS: The EC50, EC90, and EC95 of
      rocuronium fell significantly as the magnesium level increased. The EC50, EC90,
      and EC95 of rocuronium did not differ between the 3 and 4 mM groups. The recovery
      index, time to T1 height > 95% of control, and time to a TOF ratio > 0.9 after
      sugammadex administration did not differ among the four groups. CONCLUSIONS:
      Increases in the magnesium concentration in rat PNHD preparations proportionally
      enhanced the NMB induced by rocuronium but did not affect reversal by equimolar
      amounts of sugammadex.

PMID- 29843204
TI  - Differential Connectivity in Colorectal Cancer Gene Expression Network
AB  - Background: Colorectal cancer (CRC) is one of the challenging types of cancers;
      thus, exploring effective biomarkers related to colorectal could lead to
      significant progresses toward the treatment of this disease. Methods: In the
      present study, CRC gene expression datasets have been reanalyzed. Mutual
      differentially expressed genes across 294 normal mucosa and adjacent tumoral
      samples were then utilized in order to build two independent transcriptional
      regulatory networks. By analyzing the networks topologically, genes with
      differential global connectivity related to cancer state were determined for
      which the potential transcriptional regulators including transcription factors
      were identified. Results: The majority of differentially connected genes (DCGs)
      were up-regulated in colorectal transcriptome experiments. Moreover, a number of
      these genes have been experimentally validated as cancer or CRC-associated genes.
      The DCGs, including GART, TGFB1, ITGA2, SLC16A5, SOX9, and MMP7, were
      investigated across 12 cancer types. Functional enrichment analysis followed by
      detailed data mining exhibited that these candidate genes could be related to CRC
      by mediating in metastatic cascade in addition to shared pathways with 12 cancer
      types by triggering the inflammatory events. Discussion: Our study uncovered
      correlated alterations in gene expression related to CRC susceptibility and
      progression that the potent candidate biomarkers could provide a link to disease.

PMID- 29843205
TI  - Simultaneous identification and quantification of polymethoxyflavones, coumarin
      and phenolic acids in Ageratum conyzoides by UPLC-ESI-QToF-MS and UPLC-PDA.
AB  - Ageratum conyzoides L. is a plant widely used in traditional medicine of tropical
      and subtropical regions for its anti-inflammatory and antinociceptive properties.
      Nevertheless, the chemical composition of its medicinal preparation has not been
      yet accurately established. In this study, chromatographic methods were developed
      for the simultaneous identification and quantification of the main compounds in
      A. conyzoides aqueous extract, using UPLC-PDA-ESI-QToF-MS. The qualitative
      analyses defined by MS/MS analysis allowed the identification of 27 compounds in
      the aqueous extract, including the toxic pyrrolizidine alkaloids, phenolic acids,
      coumarin and polymethoxyflavones. Among the metabolites, twelve were detected for
      the first time in the species. The quantitative method was validated according to
      the official guidelines, demonstrating to be specific, linear, precise, accurate
      and sensitive for the quantification of chlorogenic acid, coumaric acid, coumarin
      (1,2-benzopyranone), 5,6,7,3',4',5'-hexamethoxyflavone, nobiletin, 5'
      methoxynobiletin and eupalestin.

PMID- 29843206
TI  - Use of ionic liquids as headspace gas chromatography diluents for the analysis of
      residual solvents in pharmaceuticals.
AB  - In this study, two ionic liquids (ILs), 1-butyl-3-methylimidazolium
      bis[(trifluoromethyl)sulfonyl]imide ([BMIM][NTf2]) and
      trihexyltetradecylphosphonium bis[(trifluoromethyl)sulfonyl]imide
      ([P66614][NTf2]) were examined as contemporary diluents for residual solvent
      analysis using static headspace gas chromatography (SHS-GC) coupled with flame
      ionization detection (FID). ILs are a class of non-molecular solvents featuring
      negligible vapor pressure and high thermal stabilities. Owing to these favorable
      properties, ILs have potential to enable superior sensitivity and reduced
      interference, compared to conventional organic diluents, at high headspace
      incubation temperatures. By employing the [BMIM][NTf2] IL as a diluent, a 25-fold
      improvement in limit of detection (LOD) was observed with respect to traditional
      HS-GC diluents, such as N-methylpyrrolidone (NMP). The established IL-based
      method demonstrated LODs ranging from 5.8 parts-per-million (ppm) to 20ppm of
      residual solvents in drug substances. The optimization of headspace extraction
      conditions was performed prior to method validation. An incubation temperature of
      140 degrees C and a 15min incubation time provided the best sensitivity for the
      analysis. Under optimized experimental conditions, the mass of residual solvents
      partitioned in the headspace was higher when using [BMIM][NTf2] than NMP as a
      diluent. The analytical performance was demonstrated by determining the
      repeatability, accuracy, and linearity of the method. Linear ranges of up to two
      orders of magnitude were obtained for class 3 solvents. Excellent analyte
      recoveries were obtained in the presence of three different active pharmaceutical
      ingredients. Owing to its robustness, high throughput, and superior sensitivity,
      the HS-GC IL-based method can be used as an alternative to existing residual
      solvent methods.

PMID- 29843207
TI  - Activity of invasive slug Limax maximus in relation to climate conditions based
      on citizen's observations and novel regularization based statistical approaches.
AB  - Citizen science is a powerful tool that can be used to resolve the problems of
      introduced species. An amateur naturalist and author of this paper, S. Watanabe,
      recorded the total number of Limax maximus (Limacidae, Pulmonata) individuals
      along a fixed census route almost every day for two years on Hokkaido Island,
      Japan. L. maximus is an invasive slug considered a pest species of horticultural
      and agricultural crops. We investigated how weather conditions were correlated to
      the intensity of slug activity using for the first time in ecology the recently
      developed statistical analyses, Bayesian regularization regression with
      comparisons among Laplace, Horseshoe and Horseshoe+ priors for the first time in
      ecology. The slug counts were compared with meteorological data from 5:00 in the
      morning on the day of observation (OT- and OD-models) and the day before
      observation (DBOD-models). The OT- and OD-models were more supported than the
      DBOD-models based on the WAIC scores, and the meteorological predictors selected
      in the OT-, OD- and DBOD-models were different. The probability of slug
      appearance was increased on mornings with higher than 20-year-average humidity
      (%) and lower than average wind velocity (m/s) and precipitation (mm) values in
      the OT-models. OD-models showed a pattern similar to OT-models in the probability
      of slug appearance, but also suggested other meteorological predictors for slug
      activities; positive effect of solar radiation (MJ) for example. Five
      meteorological predictors, mean and highest temperature ( degrees C), wind
      velocity (m/s), precipitation amount (mm) and atmospheric pressure (hPa), were
      selected as the effective factors for the counts in the DBOD-models. Therefore,
      the DBOD-models will be valuable for the prediction of slug activity in the
      future, much like a weather forecast.

PMID- 29843208
TI  - High expression of TACC2 in hepatocellular carcinoma is associated with poor
      prognosis.
AB  - BACKGROUND: Transforming acidic coiled-coil protein 2 (TACC2) is a member of TACC
      family proteins which is mainly involved in the stabilization of spindles and
      regulation of microtubule dynamics through interactions with molecules involved
      in centrosomes/microtubules. TACC2 is involved in tumorigenesis of variety of
      cancers but the clinical significance of TACC2 protein in hepatocellular
      carcinoma (HCC) is still unclear. OBJECTIVE: This study aims to investigate the
      expression of TACC2 in HCC and determine if clinical significance and prognostic
      relevance exists. METHODS: We performed quantitative PCR (qPCR) and western blot
      to examine TACC2 mRNA and protein expression in paired HCC tissues and matched
      adjacent non-cancerous tissues. Immunohistochemistry was performed in 106
      postoperative HCC samples. RESULTS: There was higher expression of TACC2 protein
      and mRNA in HCC tissue. Immunohistochemistry analysis showed high expression of
      TACC2 in HCC tissue and was significantly associated with the capsular extension,
      tumor recurrence and shortened overall and disease free survival. The Cox
      regression analysis suggested that a high expression of TACC2 was an independent
      prognostic factor for HCC patients. CONCLUSION: This finding suggests that TACC2
      may be a useful tool as a candidate biomarker to predict the recurrence and
      prognosis of HCC.

PMID- 29843209
TI  - Upregulated miR-221/222 promotes cell proliferation and invasion and is
      associated with invasive features in retinoblastoma.
AB  - BACKGROUND AND OBJECTIVES: MicroRNA (miR-221/222) is frequently overexpressed in
      many cancers and is associated with poor prognosis. However, the role of miR
      221/222 in retinoblastoma (RB) remains unclear. This study aimed to detect the
      clinical significance of miR-221/222 in RB patients and explore its role in RB
      cells in vitro. METHODS: Expression of miR-221/222 was assessed in fresh RB
      tissue collected from 64 eyes and normal retinal tissues from 18 unrelated donor
      cadaver eyes by quantitative real time RT-PCR analysis (qRT-PCR), and correlated
      with the histopathological findings. Human RB Y79 cells were transfected with miR
      221/222 precursors or inhibitors to overexpress or downregulate miR-221/222
      expression, respectively, using Lipofectamine 2000 reagent. The biological
      effects of miR-221/222 were then assessed by cell viability assays, colony
      formation assays, apoptosis detection assays, Matrigel(r) invasion assays, and
      wound-healing assays. RESULTS: Higher miR-221/222 expression was detected in RB
      tissues compared to that of the normal retinal tissues (p< 0.001). Higher miR
      221/222 expression was correlated with invasion in patients with RB. Targeting of
      miR-221/222 induced apoptosis and inhibited Y79 cell proliferation, migration,
      and invasion in vitro. However, overexpression of miR-221/222 promoted Y79 cell
      proliferation, migration, and invasion in vitro. CONCLUSIONS: Overexpression of
      miR-221/222 was associated with tumor invasiveness in patients with RB. The miR
      221/222 cluster might be used as a potential therapeutic strategy in clinical
      practice.

PMID- 29843210
TI  - Study on the methylation status of SPINT2 gene and its expression in cervical
      carcinoma.
AB  - BACKGROUND: Cervical cancer is one of the malignant tumors which seriously
      threaten the women health worldwide. SPINT2 is an endogenous inhibitor of
      hepatocyte growth factor activator and down regulated or even silenced in many
      human malignant tumors. OBJECTIVE: This study was performed to explore the
      promoter methylation status of SPINT2 gene and the effect on its expression in
      cervical carcinoma. METHODS: HPV-positive and -negative cervical cancer cell
      lines, 50 cases of cervical carcinoma tissues, and 20 cases of normal cervical
      tissues were used for this study. The methylation status of promoter and the
      first exon of SPINT2 gene were analyzed. The expression of SPINT2 was analyzed by
      qRT-PCR. RESULTS: HPV E6/E7 infection affects SPINT2 methylation rate in cell
      lines. SPINT2 methylation rate of HT-3E6/E7 was 8.8%, while the methylation rate
      of SPINT2 in HT-3 was 0%. In cervical tissues, the methylation rate of SPINT2 in
      cervical cancers was 54%, while the methylation rate of SPINT2 in normal cervical
      samples was 25%. As for cervical cancers, the methylation rate of SPINT2 gene was
      higher in grade 3 than those of grade 2. CONCLUSIONS: The expression of SPINT2
      gene is regulated by its methylation status, and the methylation status of SPINT2
      is altered by HPV infection. The aberrant methylation status of SPINT2 gene may
      play an important role in the development of cervical cancer.

PMID- 29843211
TI  - Significance of preoperative ischemia- modified albumin in operable and advanced
      gastric cancer.
AB  - BACKGROUND: Oxidative stress plays an important role in promoting proliferation
      and metastases of cancer, which can be represented by ischemia-modified albumin
      (IMA). The purpose of this study was to evaluate serum IMA level in patients with
      operable advanced gastric cancer and analyze its prognostic significance.
      MATERIALS AND METHODS: A total of 274 patients with primary stage III gastric
      cancer underwent curative operation were enrolled in this study. Serum IMA level
      was measured within 24 hours before surgery, comparing with 112 healthy donors.
      The correlation between serum IMA level and survival outcome was analyzed by the
      Kaplan-Meier with Log-Rank test and Cox's regression methods, respectively.
      RESULTS: Serum IMA level from gastric cancer was higher than healthy control
      (0.41 +/- 0.12 VS 0.23 +/- 0.08; P< 0.001). Finally, 173 and 181 patients out of
      all 274 patients studied had died and recurrent, respectively. All patients were
      stratified into two groups using the optimal cutoff value (0.45) of IMA level
      using a sensitivity of 92.5% and a specificity of 65.2% as optimal conditions
      from receiver operating curve analysis. Patients with a IMA ? 0.45 had poorer
      mean overall survival (44.68 months VS 30.94 months, P= 0.010) and mean
      recurrence free survival (42.36 months VS 28.82 months, p= 0.01) than patients
      with a IMA < 0.45 in univariate analysis and IMA also been confirmed as
      independent predictor for survival for GC patients in multivariate analysis (OR,
      0.731; 95% CI: 0.329-1.282; p= 0.023). CONCLUSIONS: Serum IMA level can be
      considered as an independent prognostic factor for operable and advanced gastric
      cancer.

PMID- 29843212
TI  - Quantum dot-based immunofluorescent imaging and quantitative detection of DNER
      and prognostic value in prostate cancer.
AB  - DNER, Delta/Notch-like epidermal growth factor (EGF)-related receptor, is a
      neuron-specific transmembrane protein carrying extracellular EGF-like repeats.
      The prognostic value of DNER in prostate cancer has not been evaluated. Here we
      showed that the up-regulation of DNER protein was observed in prostate cancer
      detected by immunohistochemistry (IHC) and quantum dot-based immunofluorescent
      imaging and quantitative analytical system (QD-IIQAS). However, a higher accuracy
      of measurements of DNER expression in prostate cancer was found by QD-IIQAS than
      by IHC (AUC = 0.817 and 0.617, respectively). DNER was significantly higher in
      patients undergoing bone metastasis (P = 0.045, RR = 3.624). In addition, DNER
      overexpression was associated with poor overall survival (OS) (P = 0.028,
      adjusted HR = 8.564) and recurrence-free survival (RFS) (P = 0.042, adjusted HR =
      3.474) in patients suffering prostate cancer. Thus, QD-IIQAS is an easy and
      accurate method for assessing DNER and the DNER expression was an independent
      prognostic factor in prostate cancer.

PMID- 29843213
TI  - Clinical potential of miR-940 as a diagnostic and prognostic biomarker in breast
      cancer patients.
AB  - BACKGROUND: Breast cancer remains the most invasive female malignancy worldwide.
      Functional role of microRNA-940 (miR-940) have been investigated in various
      cancer. The purpose of this study was to assess the serum miR-940 expression and
      its clinical significance in breast cancer. METHODS: Expression of miR-940 was
      measured by quantitative real-time polymerase chain reaction (qRT-PCR). The
      diagnostic value of miR-940 was analyzed with receiver operating characteristics
      (ROC) analysis. To explore the prognostic performance of miR-940, Kaplan-Meier
      survival assay and Cox regression analysis were performed. RESULTS: Downregulated
      miR-940 was detected in the breast cancer patients compared with the healthy
      controls (P< 0.001). The miR-940 expression was correlated with lymph node
      metastasis (P= 0.014) and TNM stage (P= 0.003). The area under the ROC curve
      (AUC) was 0.905, with sensitivity and specificity of 94.5% and 78.6%. From the
      survival curves, patients with low miR-940 expression had poor overall survival
      compare with those with high expression (log-rank P= 0.009). The Cox analysis
      indicated that miR-940 was an independent prognostic factor (HR = 2.645, 95% CI =
      1.426-4.906 and P= 0.002). Decreased miR-940 expression was also been found in
      triple-negative breast cancer (TNBC) samples, and might predict poor prognosis in
      TNBC patients. CONCLUSIONS: Serum downregulated miR-940 may serve as a reliable
      diagnostic and prognostic biomarker in breast cancer patients.

PMID- 29843214
TI  - Screening and function analysis of hub genes and pathways in hepatocellular
      carcinoma via bioinformatics approaches.
AB  - BACKGROUND: Liver carcinoma is a major cause of cancer-related death worldwide.
      Up to date, the mechanisms of liver cancerigenesis and development have not been
      fully understood. Multi-genes and pathways were involved in the tumorigenesis of
      liver cancer. OBJECTIVE: The aim of the present study was to screen key genes and
      pathways in liver cancerigenesis and development by using bioinformatics methods.
      METHODS: A dataset GSE64041 were retrieved from GEO database and the
      differentially expressed genes (DEGs) were screened out. Then the DEG functions
      were annotated by gene ontology (GO) and pathway enrichment analysis,
      respectively. The hub genes were further selected by protein-protein interaction
      (PPI) analysis. Afterwards, the mRNA and protein expressions as well as the
      prognostic values of the hub genes were assessed. RESULTS: As a result, 208 up
      regulated and 82 down-regulated genes were screened out. These DEGs were mainly
      enriched in cell cycle and metabolism-related pathways. Through PPI analysis,
      TOP2A, PRDM10, CDK1, AURKA, BUB1, PLK1, CDKN3, NCAPG, BUB1B and CCNA2 were
      selected as hub genes, which were all over-expressed in liver cancers relative to
      those in normal tissues, respectively. Among them, PLK1 and CCNA2 were suggested
      to be prognostic factors for liver carcinoma. CONCLUSION: In conclusion, the
      present study identified several hub genes, and cell cycle and metabolism-related
      pathways that may play critical roles in the tumorigenesis of liver cancer.
      Future validation laboratory experiments are required to confirm the results.

PMID- 29843215
TI  - The correlation between mammographic densities and molecular pathology in breast
      cancer.
AB  - This study aimed to analyze the correlation between mammographic density obtained
      by density analysis software (DAS)/radiologists visual (RV) classification with
      molecular subtype, and the expression levels of estrogen receptor (ER),
      progesterone receptor (PR), Ki67 antigen (Ki-67), p53 gene (p53), and human
      epidermal growth factor receptor-2 (HER2). A total of 688 breast cancer patients
      with digital mammography and complete molecular pathological results in Tianjin
      Medical University Cancer Institute and Hospital between February 2015 and
      February 2016 were collected. The DAS-density grade (DASD) and the radiologists
      visually classified density grade (RVD) were evaluated by 3 radiologists. The
      correlation between density grade and the expression levels of ER, PR, Ki-67,
      p53, HER2 and breast cancer molecular subtype (PMS) were analyzed. The agreement
      between DASD and RVD was explored. ER, PR and HER-2 positive rate were
      significantly different among patients with different RVD grades (P< 0.05). HER2
      positive rates showed an increasing trend following RVD upgrading (P??????????<
      0.05). HER-2 positive rate in RVD D1 + D2 was 7.69%, which was higher than that
      in D3 + D4 (P< 0.05). The ER and Ki-67 expressions in patients were markedly
      different among DASD (P= 0.009 and 0.002) and RVD (P= 0.012 and 0.036) with
      different grades. The kappa value of each DASD to RVD was 0.31 (P< 0.01). The RVD
      3 proportion was 14.58% (63/432) in HER2 Over-expressing subtype, which was
      apparently higher than RVD1 (2.43%, 1/41) (P< 0.05). Breast density may be
      partial correlated with molecular pathology in breast cancer.

PMID- 29843216
TI  - Transcription factor KLF13 inhibits AKT activation and suppresses the growth of
      prostate carcinoma cells.
AB  - BACKGROUND: Kruppel-like factor 13 (KLF13), a member of the KLF family, is
      involved in the development of immunological diseases and tumor progression.
      However, the expression patterns and potential functions of KLF13 in prostate
      carcinoma are still unknown. Here, we aimed to study the roles and mechanisms of
      KLF13 in prostate cancer. METHODS: The expression levels of KLF13 was detected by
      Immunohistochemistry in prostate tumor tissues and the paired non-tumor tissues.
      The effects of KLF13 up-regulation was tested by performing CCK8, cell colon
      formation, flow cytometric analysis and measurement of tumor proliferation in
      nude mice. Signaling pathway was analyzed by Western blot. RESULTS: The current
      study, for the first time, found that KLF13 was downregulated in prostate tumor
      tissues as compared to the paired non-tumor tissues. The overexpression of KLF13
      dramatically inhibited cell proliferation and induced apoptosis by suppressing
      the AKT pathway in human prostate cancer cells. Moreover, the ectopic expression
      of KLF13 efficiently delayed the onset of PC3 xenografts and inhibited the tumor
      growth in vivo. CONCLUSIONS: KLF13 functions as a tumor suppressor protein in
      PCa, and the pharmacological activation of KLF13 might represent a potential
      approach for the treatment of prostate cancer.

PMID- 29843217
TI  - Sulfatase 1 expression in pancreatic cancer and its correlation with
      clinicopathological features and postoperative prognosis.
AB  - BACKGROUND: Recent studies have shown that Sulfatase 1 (SULF1) plays a crucial
      role in the genesis, development, and progression of tumors. However, there have
      been few studies on the role of SULF1 in pancreatic cancer. OBJECTIVE: The
      present study examined the differences in SULF1 expression levels between
      pancreatic cancer and normal tissues, and their correlation with the
      clinicopathological features and prognosis. METHODS: A total of 65 pancreatic
      cancer samples were enrolled in this study. An immunohistochemical assay were
      used in this study. The relationship between SULF1 expression and
      clinicopathological features were tested using chi2 test or Fisher's exact test.
      The Kaplan-Meier method was used to calculate the cumulative survival rates of
      the patients. RESULTS: The study showed that the SULF1 expression level was
      higher in pancreatic cancer tissues than in normal tissues. Analysis of the
      clinical and pathological data of patients revealed that high SULF1 expression
      was associated with later T, N, and TNM stages, higher CA19-9 levels, smaller
      tumor size, and poorer prognosis. CONCLUSIONS: These findings suggested that
      SULF1 could be an indicator of the clinicopathological features and prognosis of
      pancreatic cancer.

PMID- 29843218
TI  - Reduced mean platelet volume is associated with poor prognosis in esophageal
      cancer.
AB  - BACKGROUND: Esophageal cancer (EC) is the sixth most common cause of death from
      cancer. Altered mean platelet volume (MPV) levels were found in patients with
      malignancies. OBJECTIVE: The present study investigated whether MPV can predict
      the survival in EC patients. MEHTODS: The clinical data of 236 consecutive EC
      patients between January 2009 and December 2009 in our center were
      retrospectively analyzed. The overall survival rate was estimated using Kaplan
      Meier method. Cox proportional hazards models were fitted to model the
      relationships between patient characteristics and prognosis. RESULTS: Decreased
      MPV was significantly correlated with tumor location and tumor differentiation
      (p< 0.001). Moreover, survival analysis revealed that the overall survival of
      patients with MPV ? 7.4 fL was significantly shorter than that of those with MPV
      > 7.4 fL. Multivariate analysis identified MPV as an independent poor prognostic
      factor for overall survival. CONCLUSIONS: Reduced MPV is associated with worse
      survival outcome in EC.

PMID- 29843219
TI  - The clinicopathological and prognostic significances of Dkk3 expression in
      cancers: A bioinformatics analysis.
AB  - BACKGROUND: Dkk3 protein attenuates the expression of Wnt3a, Wnt5a and LRP6, and
      their interaction, and interacts with betaTrCP to suppress wnt/beta-catenin
      pathway. METHODS: We performed a bioinformatics analysis of Dkk3 mRNA expression
      through Oncomine, TCGA and Kaplan-Meier databases up to July 10, 2017. RESULTS:
      Up-regulated Dkk3 expression was higher in gastric, breast, and ovarian cancers
      than normal tissues (p< 0.05). Bitter's database showed a higher Dkk3 expression
      in ovarian cytoadenocarcinoma than clear cell adenocarcinoma (p< 0.05). Dkk3 was
      more expressed in ductal breast cancer in situ than invasive ductal breast cancer
      (p< 0.05), in mixed lobular and ductal cancer, and lobular cancer than ductal
      breast cancer (p< 0.05). In TCGA data, Dkk3 expression was lower in gastric
      cancers with than without Barret's esophagus (p< 0.05), and in the cancers of
      elder than younger patients (p< 0.05). Dkk3 expression was higher in squamous
      cell carcinoma than adenocarcinoma (p< 0.05). Dkk3 expression was higher in
      ductal than lobular breast cancer, or in younger than elder patients with breast
      cancer (p< 0.05). According to Kaplan-Meier plotter, Dkk3 expression was
      negatively correlated with overall, progression-free, relapse-free or distant
      metastasis-free survival rate of gastric, breast or ovarian cancer patients, but
      versa for lung cancer patients (p< 0.05). CONCLUSION: Dkk3 expression might be
      employed as a potential marker to indicate carcinogenesis and histogenesis, even
      prognosis.

PMID- 29843220
TI  - Long non-coding RNA GHET1 promotes human breast cancer cell proliferation,
      invasion and migration via affecting epithelial mesenchymal transition.
AB  - OBJECTIVE: Breast cancer is a common malignancy in women and long non-coding RNAs
      (lncRNAs) have been shown to play key roles in the development and progression of
      breast cancer. In the present study, we examined the biological role of lncRNA
      gastric carcinoma highly expressed transcript 1 (GHET1) in breast cancer.
      METHODS: The expression of GHET1 was determined by qRT-PCR assay; CCK-8, colony
      formation, Transwell invasion and migration assays detected breast cancer cell
      proliferation, invasion and migration; cell apoptosis and cell cycle were
      determined by flow cytometry; protein levels were determined by western blot
      assay. RESULTS: GHET1 was up-regulated in breast cancer tissues and cell lines,
      and the up-regulation of GHET1 was positively correlated with larger tumor size,
      advanced clinical stage, lymph node metastasis and shorter overall survival.
      Knockdown of GHET1 suppressed cell proliferation, invasion and migration, and
      induced apoptosis and G0/G1 cell cycle arrest in MCF-cells. Knockdown of GHET1
      also suppressed the protein levels of N-cadherin, vimentin, and decreased the
      protein level of E-cadherin in MCF-7 cells. On the other hand, overexpression of
      GHET1 promoted cell proliferation, invasion and migration, and inhibited cell
      apoptosis and increased cell population at S phase in BT-20 cells. Overexpression
      of GHET1 also promoted epithelial mesenchymal transition (EMT) in BT-20 cells.
      Furthermore, knockdown of GHET1 also suppressed in vivo tumor growth of MCF-7
      cells, and also decreased the protein levels of N-cadherin and vimentin, and
      increased the protein levels of E-cadherin in the tumor tissues from the nude
      mice. CONCLUSIONS: Our results demonstrated that GHET1 was up-regulated in breast
      cancer tissues and cell lines, and promoted breast cancer cell proliferation,
      invasion and migration by affecting EMT. Our study for the first time revealed
      the biological functions of GHET1 in breast cancer.

PMID- 29843221
TI  - Serum miR-126 level combined with multi- detector computed tomography in the
      preoperative prediction of lymph node metastasis of gastric cancer.
AB  - BACKGROUND: Predicting lymph node metastasis (LNM) accurately is vital to design
      optimal treatment strategies preoperatively for gastric cancer (GC) patients.
      However, conventional tumor biomarkers and imaging techniques are not sufficient
      to predict LNM before surgery. miR-126 has been reported to play important roles
      in tumor metastasis which may represent a novel tumor biomarker. OBJECTIVE: To
      assess the utility of the combination of serum miR-126 and multi-detector
      computed tomography (MDCT) in predicting LNM preoperatively in GC. METHODS:
      Quantitative real-time polymerase chain reaction was performed to examine the
      serum miR-126 expression levels in 338 GC patients. MDCT was also performed. The
      cut-off value of preoperative serum miR-126 level for LNM was determined by
      receiver characteristic curve (ROC) analysis. Logistic regression analysis was
      used to determine independent predictors for LNM. RESULTS: The serum miR-126
      levels of GC patients with LNM were significantly lower compared with those
      without LNM (p< 0.05). In addition, the later the N stage was, the lower the
      serum miR-126 level was in GC patients (p< 0.05). With a cut-off value of 63.4,
      the sensitivity, specificity, accuracy, positive predictive value and negative
      predictive value of serum miR-126 for predicating LNM were 83.2%, 79.0%, 81.9%,
      90.4% and 66.4%, respectively. The combination of serum miR-126 level and MDCT
      increased the accuracy of MDCT prediction for LNM from 69.2% to 86.7%. Serum miR
      126 was an independent predictor for LNM. CONCLUSIONS: These results indicate for
      the first time that the combination of serum miR-126 and MDCT is useful for the
      prediction of LNM in GC.

PMID- 29843222
TI  - Effect of Bmi-1-mediated NF-kappaB signaling pathway on the stem-like properties
      of CD133+ human liver cancer cells.
AB  - OBJECTIVE: To investigate the impact of Bmi-1-mediated NF-kappaB pathway on the
      biological characteristics of CD133+ liver cancer stem cells (LCSCs). METHODS:
      Flow cytometry was used to isolate CD133+ LCSC cells from Huh7, Hep3B, SK-hep1,
      and PLC/PRF-5 cells. CD133+ Huh7 cells were divided into Control, Blank, Bmi-1
      siRNA, JSH-23 (NF-kappaB pathway inhibitor), and Bmi-1 + JSH-23 groups. The
      properties of CD133+ Huh7 cells were detected by the colony-formation and sphere
      forming assays. Besides, Transwell assay was applied for the measurement of cell
      invasion and migration, immunofluorescence staining for the detection of NF
      kappaB p65 nuclear translocation, and qRT-PCR and Western blotting for the
      determination of SOX2, NANOG, OCT4, Bmi-1, and NF-kappaB p65 expression. RESULTS:
      CD133+ Huh-7 cells were chosen as the experiment subjects after flow cytometry.
      Compared with CD133- Huh-7 cells, the expression of CD133, OCT4, SOX2, NANOG, Bmi
      1, and NF-kappaB p65, the nuclear translocation of NF-kappaB p65, the number of
      cell colonies and Sphere formation, as well as the abilities of invasion and
      migration were observed to be increased in CD133+ Huh-7 cells, which was
      inhibited after treated with Bmi-1 siRNA or JSH-23, meanwhile, the cell cycle was
      arrested at the G0/G1 and S phases with apparently enhanced cell apoptosis.
      Importantly, no significant differences in the biological characteristics of
      CD133 + Huh-7 cells were found between the Blank group and Bmi-1 + JSH-23 group.
      CONCLUSION: Down-regulating Bmi-1 may inhibit the biological properties of CD133+
      LCSC by blocking NF-kappaB signaling pathway, which lays a scientific foundation
      for the clinical treatment of liver cancer.

PMID- 29843223
TI  - Up-regulation of long noncoding RNA uc.338 predicts poor survival in non-small
      cell lung cancer.
AB  - BACKGROUND: Long noncoding RNA ultraconserved element 338 (uc.338) is a long non
      coding RNA reported to function as a promoter in non-small cell lung cancer
      (NSCLC). However, the function and potential mechanism of uc.338 in NSCLC is
      still unclear. OBJECTIVE: The aim of the present study was to assess the effect
      of uc.338 on the prognosis of patients with NSCLC. METHODS: The expression levels
      of uc.338 in NSCLC tissues and matched normal lung tissues were examined by real
      time quantitative PCR. Then the association between uc.338 levels with clinical
      variables as well as survival time was investigated. RESULTS: We found that
      uc.338 expression levels were significantly upregulated in NSCLC compared with
      the matched noncancerous lung tissues (P< 0.01). In addition, increased uc.338
      expression was significantly associated with TNM stage (P< 0.003), lymph node
      metastasis (P< 0.006) and distant metastasis (P< 0.002). More importantly, Kaplan
      Meier survival analysis demonstrated that higher uc.338 expression levels were
      associated with a shorter overall survival (P< 0.0016) and disease-free survival
      (p< 0.0001) in NSCLC patients. Finally, univariate and multivariate Cox
      regression analyses revealed that uc.338 was an independent risk factor for
      overall survival and disease-free survival. CONCLUSIONS: Our results show that
      uc.338 may play an important role in tumorigenesis and progression and could
      serve as a potential independent prognostic biomarker for patients with NSCLC.

PMID- 29843224
TI  - Up-regulation of regulatory T cells, CD200 and TIM3 expression in cytogenetically
      normal acute myeloid leukemia.
AB  - BACKGROUND: The bone marrow immunosuppressive microenvironment of AML patients
      sustains and modulates proliferation, survival and drug resistance of AML through
      deregulation of both innate and adaptive immune response. We aimed to investigate
      the level of Tregs, expression of Tim-3 on peripheral blood T cells, expression
      of CD200 in myeloid blasts in newly diagnosed AML patients with normal
      cytogenetics (AML-NC) and their prognostic impact. PATIENTS AND METHODS: This
      study included 40 patients with de novo AML-NC and 20 healthy controls. Flow
      cytometry was used for detection of CD4+CD25+high FoxP3+ regulatory T cells, Tim
      3 expression on peripheral blood T cells and CD200 expression on myeloid blasts.
      RESULTS: The percentages of CD4+CD25+high and CD4+CD25+high Foxp3+ Tregs were
      significantly increased in AML patients than controls. The levels of Tregs, Tim
      3/CD4+, Tim-3/CD8+, CD200 and MFI of CD200 were significantly lower in responding
      patients than in those with persistent leukemia. Only high CD200 expression (>
      50%) showed statistically significant worse OS with P< 0.04. CONCLUSION: The
      increased levels of Tregs, Tim-3 expression on peripheral blood T cells and CD200
      expression in myeloid blast in AML patients could play a role in the development
      of AML. Analysis of these markers could serve as prognostic markers and might
      guide the therapy in AML patients in the future.

PMID- 29843225
TI  - Acoustic radiation force impulse elastography in evaluation of triple-negative
      breast cancer: A preliminary experience.
AB  - PURPOSE: To assess the elastographic features of triple-negative breast cancers
      and evaluate the diagnostic value of acoustic radiation force impulse imaging
      (ARFI) for the characterization of triple-negative breast cancers. MATERIALS AND
      METHODS: This study analyzed data from 234 women with breast cancer. Patients
      were categorized into three groups; 1) triple-negative breast cancers (n = 48);
      2) ER-positive tumors (n = 128) and 3) HER2-positive tumors (n = 58). Mean tumor
      stiffness was evaluated by virtual touch tissue imaging (VTI) and virtual touch
      tissue quantification (VTQ) and quantified as both qualitative scores (1-5) and
      shear wave velocity (SWV) (m/s). The relationship between mean SWV and tumor
      parameters, including tumor size, tumor type, histologic grade and lymph node
      status, were investigated using multiple linear regression. RESULTS: Triple
      negative tumor were more likely to have a large invasive size (p = 0.002), high
      histological grade (p < 0.001), lymph node involvement (p = 0.022) and strong ki
      67 expression (p < 0.001). The highest mean SWV value were recorded in triple
      negative tumors (7.36 m/s+/-1.83), followed by HER2+ tumors (6.65 m/s+/-2.26) and
      ER+ tumors (6.60 m/s+/-2.35) (p = 0.122). Triple-negative tumors were also
      associated with increased stiffness than ER+ tumors and HER2+ tumors (p = 0.016),
      as measured by qualitative VTI scores. Tumor size was independently associated
      with mean SWV value on adjusted regression (p < 0.001). CONCLUSIONS: Triple
      negative breast cancer is associated with high stiffness scores and SWV in ARFI.
      The latter may be considered a useful complementary tool in evaluation of triple
      negative breast cancer.

PMID- 29843226
TI  - Preinterventional hydrocortisone sustains the endothelial glycocalyx in cardiac
      surgery.
AB  - BACKGROUND: Patients undergoing cardiac surgery commonly develop systemic
      inflammation associated with tissue edema, which impairs outcome. One main
      pathomechanism leading to the edema is the deterioration of the endothelial
      glycocalyx, a key component of the vascular barrier. In animal models
      hydrocortisone has proved to be protective for the glycocalyx. OBJECTIVE: This
      trial evaluates the effect of hydrocortisone on glycocalyx integrity in patients
      undergoing cardiac surgery with cardiopulmonary bypass. METHODS: In a
      prospective, randomized interventional pilot trial, 30 patients received either
      hydrocortisone (100 mg over 10 min) or placebo (saline control) before surgery.
      Plasma concentrations of glycocalyx constituents (syndecan-1, heparan sulfate)
      and various clinical parameters (respiratory and renal function, inflammatory
      markers, use of vasopressors, length of stay at the intensive care unit) were
      measured. Primary endpoint was a significant difference of glycocalyx
      constituents in plasma. Comparisons were made with Friedman's and Wilcoxon tests
      (paired data), or the Kruskal-Wallis and Mann-Whitney U tests (unpaired data).
      Holm-Bonferroni method was used for post-hoc corrections. RESULTS: Heparan
      sulfate and syndecan-1 increased significantly during and after cardiac surgery
      with cardiopulmonary bypass in both groups. Whereas the maximum increase of
      heparan sulfate was 12.3-fold in the control vs. 3.8-fold in the pretreated group
      (p < 0.05), syndecan-1 values showed no significant difference between the groups
      (maximal increase 3-fold). The inflammatory markers C-reactive protein and
      interleukin-6 were also higher in the control than in the hydrocortisone group,
      but there was no difference in patient mortality (zero), or in any clinical
      parameters. CONCLUSIONS: Pretreatment with hydrocortisone ameliorated shedding of
      heparan sulfate, a major constituent of the endothelial glycocalyx, in patients
      undergoing cardiac surgery with cardiopulmonary bypass, but had no relevant
      influence on various clinical parameters or patient mortality. The relatively
      small number of patients in this pilot study probably precluded detection of
      positive outcome differences.

PMID- 29843227
TI  - Impact of plasma viscosity on microcirculatory flow after traumatic haemorrhagic
      shock: A prospective observational study.
AB  - BACKGROUND: Preclinical studies report that higher plasma viscosity improves
      microcirculatory flow after haemorrhagic shock and resuscitation, but no clinical
      study has tested this hypothesis. OBJECTIVE: We investigated the relationship
      between plasma viscosity and sublingual microcirculatory flow in patients during
      resuscitation for traumatic haemorrhagic shock (THS). METHODS: Sublingual video
      microscopy was performed for 20 trauma patients with THS as soon as feasible in
      hospital, and then at 24 h and 48 h. Values were obtained for total vessel
      density, perfused vessel density, proportion of perfused vessels,
      microcirculatory flow index (MFI), microcirculatory heterogeneity index (MHI),
      and Point of Care Microcirculation (POEM) scores. Plasma viscosity was measured
      using a Wells-Brookfield cone and plate micro-viscometer. Logistic regression
      analyses examined relationships between microcirculatory parameters and plasma
      viscosity, adjusting for covariates (systolic blood pressure, heart rate,
      haematocrit, rate and volume of fluids, and rate of noradrenaline). RESULTS:
      Higher plasma viscosity was not associated with improved microcirculatory
      parameters. Instead, there were weakly significant associations between higher
      plasma viscosity and lower (poorer) MFI (p = 0.040), higher (worse) MHI (p =
      0.033), and lower (worse) POEM scores (p = 0.039). CONCLUSIONS: The current study
      did not confirm the hypothesis that higher plasma viscosity improves
      microcirculatory flow dynamics in patients with THS. Further clinical
      investigations are warranted to determine whether viscosity is a physical
      parameter of importance during resuscitation of these patients.

PMID- 29843228
TI  - The efficacy of added shear wave elastography (SWE) in breast screening for women
      with inconsistent mammography and conventional ultrasounds(US).
AB  - PURPOSE: To evaluate the efficacy of added shear wave elastography (SWE) in
      breast screening for women with results inconsistent between mammography and
      conventional ultrasounds (US). MATERIALS AND METHODS: The study consisted of 282
      pathologically proven breast lesions. The cancer probability from screening by
      mammography and conventional US were scored using Breast Imaging Reporting and
      Data System (BI-RADS). Elastography was used to re-evaluate inconsistent
      conventional US and mammography results. The diagnostic performance of
      conventional US, mammography, and Combined conventional clinical imaging and SWE
      was compared. The clinicopathological features of all breast cancer patients with
      inconsistent (and consistent) conventional US and mammography findings were
      compared. RESULT: Finally, 147 lesions were confirmed benign and 135 were
      malignant. The AUC of Combined conventional clinical imaging plus elastography
      imaging (0.870) was significantly higher than mammography (0.735, p < 0.001) or
      conventional US (0.717, p < 0.001) alone. Among the 135 breast cancers, 79 of the
      conventional US and mammography findings were consistent and 56 were
      inconsistent. Younger age(<50y) (p = 0.035), non-invasive (p = 0.037), smaller
      size (p = 0.002) and negative lymph node status (p = 0.026) were significantly
      associated with inconsistent findings. CONCLUSION: The added SWE in breast
      screening when inconsistent results from mammography and conventional US occurred
      is necessary and effective.

PMID- 29843229
TI  - Comparison of two substrate materials used as negative control in
      endothelialization studies: Glass versus polymeric tissue culture plate.
AB  - The endothelialization of synthetic surfaces applied as cardiovascular implant
      materials is an important issue to ensure the anti-thrombotic quality of a
      biomaterial. However, the rapid and constant development of a functionally
      confluent endothelial cell monolayer is challenging. In order to investigate the
      compatibility of potential implant materials with endothelial cells several in
      vitro studies are performed. Here, glass and tissue culture plates (TCP) are
      often used as reference materials for in vitro pre-testing. However, a direct
      comparison of both substrates is lacking.Therefore, a comparison of study results
      is difficult, since results are often related to various reference materials. In
      this study, the endothelialization of glass and TCP was investigated in terms of
      adherence, morphology, integrity, viability and function using human umbilical
      vein endothelial cells (HUVEC).On both substrates an almost functionally
      confluent HUVEC monolayer was developed after nine days of cell seeding with
      clearly visible cell rims, decreased stress fiber formation and a pronounced
      marginal filament band. The viability of HUVEC was comparable for both substrates
      nine days after cell seeding with only a few dead cells. According to that, the
      cell membrane integrity as well as the metabolic activity showed no differences
      between TCP and glass. However, a significant difference was observed for the
      secretion of IL-6 and IL-8. The concentration of both cytokines, which are
      associated with migratory activity, was increased in the supernatant of HUVEC
      seeded on TCP. This result matches well with the slightly increased number of
      adherent HUVEC on TCP.In conclusion, these findings indicate that both reference
      materials are almost comparable and can be used equivalently as control materials
      in in vitro endothelialization studies.

PMID- 29843230
TI  - Pneumococcal disease burden, clinical presentations and vaccine coverage in the
      Jamaican population.
AB  - BACKGROUND: Pneumococcal serotypes circulating in any population vary over time
      and between countries and impacts the effectiveness of pneumococcal vaccination.
      OBJECTIVE: This study investigated the epidemiology of pneumococcal disease in
      Jamaica. METHODS: Streptococcus pneumoniae isolates (n= 349) along with
      demographic and clinical information were collected from patients presenting at
      the 4 major hospitals in Jamaica over a 2-year period. Serotyping was done using
      latex agglutination tests and the Quellung reaction assay. RESULTS: Invasive
      pneumococcal disease (IPD) incidence was 45.4/100,000 in children under 5 yrs and
      16.3/100,000 in adults over 65 yrs. Thirteen serogroups were identified among the
      120 isolates subjected to grouping; the most common being serogroups: 19
      (22/120,18.3%), 6 (20/120,16.7%), 14 (20/120,16.7%), 23 (18/120,15.0%), 3
      (11/120,9.2%) and nontypeable (8/120,2.3%). The estimated vaccine coverage rates
      for the PCV7 and PCV13 vaccines in children less than 5 yrs were 82.5% and 88.7%
      respectively. The 23-valent PPV23 provided 100% coverage rate in adults over 65
      yrs and 82.9% coverage rate for the entire population. CONCLUSIONS: Pneumococcal
      vaccine coverage rates in Jamaica are comparable to those reported in certain
      developed countries and higher than in other developing countries. The high
      incidence of IPD in the paediatric population indicates that routine vaccination
      would be beneficial.

PMID- 29843231
TI  - TNF-alpha -308G/A gene polymorphism in bullous pemphigoid and alopecia areata.
AB  - BACKGROUND: TNF-alpha -308G/A polymorphism has been investigated in few studies
      for an association with susceptibility to bullous pemphigoid (BP) and alopecia
      areata (AA). Yet, these findings had so far not been independently replicated,
      and no data on a possible association of TNFalpha -308G/A polymorphism with these
      diseases in Iranian population were available. OBJECTIVES: In the present study,
      a possible effect of TNF-alpha -308G/A variation on susceptibility to BP or AA
      disease was evaluated. METHODS: Genomic DNA was extracted from the blood of the
      patients with BP and AA as well as control subjects which genotyped for the TNF
      alpha -308 G/A polymorphism. TNF-alpha gene expression levels were analyzed by
      real-time RT-PCR. RESULTS: No association was observed between the TNF-alpha -308
      G/A variation and susceptibility to BP or AA diseases in our Iranian cohort. In
      contrast to AA patients, expression of TNF-alpha gene was significantly higher in
      BP patients compared to control group. TNF-alpha gene was found to be similarly
      expressed in mutant and wild-type genotypes. CONCLUSIONS: TNF-alpha -308G/A
      polymorphism is not associated with the risk to develop of BP and AA in our
      Iranian cohort. Furthermore, this polymorphism is contributed to altering the
      levels of gene expression in BP disease.

PMID- 29843232
TI  - A 'Framingham-like' Algorithm for Predicting 4-Year Risk of Progression to
      Amnestic Mild Cognitive Impairment or Alzheimer's Disease Using Multidomain
      Information.
AB  - BACKGROUND: There are no agreed-upon variables for predicting progression from
      unimpaired cognition to amnestic mild cognitive impairment (aMCI), or from aMCI
      to Alzheimer's disease (AD). OBJECTIVE: Use ADNI data to develop a 'Framingham
      like' prediction model for a 4-year period. METHODS: We developed models using
      the strongest baseline predictors from six domains (demographics, neuroimaging,
      CSF biomarkers, genetics, cognitive tests, and functional ability). We chose the
      best predictor from each domain, which was dichotomized into more versus less
      harmful. RESULTS: There were 224 unimpaired individuals and 424 aMCI subjects
      with baseline data on all predictors, of whom 37 (17% ) and 150 (35% ) converted
      to aMCI and AD, respectively, during 4 years of follow-up. For the unimpaired,
      CSF tau/Abeta ratio, hippocampal volume, and a memory score predicted
      progression. For those aMCI at baseline, the same predictors plus APOE4 status
      and functional ability predicted progression. Demographics and family history
      were not important predictors for progression for either group. The fit statistic
      was good for the unimpaired-aMCI model (C-statistic 0.80) and very good for the
      aMCI-AD model (C-statistic 0.91). Among the unimpaired, those with no harmful
      risk factors had a 4-year predicted 2% risk of progression, while those with the
      most harmful risk factors had a predicted 35% risk. The aMCI subjects with no
      harmful risk factors had a predicted 1% risk of progression those with all six
      harmful risk factors had a predicted 90% risk. CONCLUSION: Our parsimonious model
      accurately predicted progression from unimpaired to aMCI with three variables,
      and from aMCI to AD with five variables.

PMID- 29843233
TI  - Pink1 Regulates Tyrosine Hydroxylase Expression and Dopamine Synthesis.
AB  - PTEN induced putative kinase 1 (PINK1), also known as PARK6, is causally linked
      to familial Parkinsonism, and heterozygous loss of PINK1 is a risk factor for
      sporadic Parkinson's disease. However, little is known about its physiological
      function. Its deficiency was shown to decrease dopamine without significant loss
      of dopaminergic neurons. We investigated the mechanistic basis for this
      observation in the present study using dopaminergic MN9D cells. We found that
      PINK1 knockdown resulted in dopamine content to decrease with suppressed tyrosine
      hydroxylase expression in cells. Conversely, PINK1 overexpression increased
      tyrosine hydroxylase protein level. We also found that PINK1 deficiency blocked
      the nuclear translocation and activity of nuclear receptor-related 1, a
      transcription factor regulating tyrosine hydroxylase gene expression. These data
      suggest that PINK1 regulates tyrosine hydroxylase gene expression and dopamine
      content by modulating the transcriptional activity of nuclear receptor-related 1.
      Taken together, our results reveal a novel function of PINK1 in dopamine
      homeostasis.

PMID- 29843234
TI  - Total MRI Small Vessel Disease Burden Correlates with Cognitive Performance,
      Cortical Atrophy, and Network Measures in a Memory Clinic Population.
AB  - BACKGROUND: Recent evidence suggests that combining individual imaging markers of
      cerebral small vessel disease (SVD) may more accurately reflect its overall
      burden and better correlate with clinical measures. OBJECTIVE: We wished to
      establish the clinical relevance of the total SVD score in a memory clinic
      population by investigating the association with SVD score and cognitive
      performance, cortical atrophy, and structural network measures, after adjusting
      for amyloid-beta burden. METHODS: We included 243 patients with amnestic mild
      cognitive impairment (MCI), Alzheimer's disease dementia, subcortical vascular
      MCI, or subcortical vascular dementia. All underwent MR and [11C] PiB-PET
      scanning and had standardized cognitive testing. Multiple linear regression was
      used to evaluate the relationships between SVD score and cognition, cortical
      thickness, and structural network measures. Path analyses were performed to
      evaluate whether network disruption mediates the effects of SVD score on cortical
      thickness and cognition. RESULTS: Total SVD score was associated with the
      performance of frontal (beta - 4.31, SE 2.09, p = 0.040) and visuospatial (beta -
      0.95, SE 0.44, p = 0.032) tasks, and with reduced cortical thickness in
      widespread brain regions. Total SVD score was negatively correlated with nodal
      efficiency, as well as changes in brain network organization, with evidence of
      reduced integration and increasing segregation. Path analyses showed that the
      associations between SVD score and frontal and visuospatial scores were partially
      mediated by decreases in their corresponding nodal efficiency and cortical
      thickness. CONCLUSION: Total SVD burden has clinical relevance in a memory clinic
      population and correlates with cognition, and cortical atrophy, as well as
      structural network disruption.

PMID- 29843235
TI  - Parkinsonism is a Phenotypical Signature of Amyloidopathy in Patients with Gait
      Disorders.
AB  - BACKGROUND: Central neurological gait abnormalities (CNGA) are frequently
      associated with parkinsonism in older adults. However, the neuropathological
      substrates and the clinical impact of parkinsonism have been not described in
      CNGA. OBJECTIVE: This cross-sectional study aims to compare the CSF total tau,
      Abeta1-42, and phosphorylated tau levels in non-Parkinson's disease (PD) patients
      with CNGA with and without parkinsonism and to study the clinical impact of
      parkinsonism on gait and cognition. METHODS: CSF biomarkers were measured by
      ELISA in 49 non-PD patients with CNGA (77.7+/-6.6 years; 32.7% women). Gait was
      quantified with an optoelectronic system and cognition with a comprehensive
      neuropsychological assessment. Parkinsonism was defined by presence of
      bradykinesia and at least one of the following signs among muscular rigidity,
      rest tremor, or postural instability. RESULTS: Parkinsonism was identified in 14
      CNGA patients (28.6% ). CSF Abeta1-42 level was decreased in CNGA patients with
      parkinsonism (beta: - 189.4; 95% CI [- 352.3; - 26.6]; p = 0.024) even after
      adjusting for age, gender, comorbidities, and total white matter burden; while
      CSF total tau and phosphorylated tau levels were similar between CNGA patients
      with and without parkinsonism. CNGA patients with parkinsonism presented
      decreased attentional and executive performances but similar gait parameters than
      those without parkinsonism. CONCLUSION: Parkinsonism represents a phenotype
      related with amyloidopathy-decreased CSF Abeta1-42 level-in non-PD patients with
      CNGA. This phenotype is clinically associated with impaired cognition, but
      similar quantitative gait parameters in comparison to CNGA patients without
      parkinsonism.

PMID- 29843236
TI  - Immunohistochemical Analysis of Activin Receptor-Like Kinase 1 (ACVRL1/ALK1)
      Expression in the Rat and Human Hippocampus: Decline in CA3 During Progression of
      Alzheimer's Disease.
AB  - The pathophysiology of Alzheimer's disease (AD) includes signaling defects
      mediated by the transforming growth factor beta-bone morphogenetic protein-growth
      and differentiation factor (TGFbeta-BMP-GDF) family of proteins. In animal models
      of AD, administration of BMP9/GDF2 improves memory and reduces amyloidosis. The
      best characterized type I receptor of BMP9 is ALK1. We characterized ALK1
      expression in the hippocampus using immunohistochemistry. In the rat, ALK1
      immunoreactivity was found in CA pyramidal neurons, most frequently and robustly
      in the CA2 and CA3 fields. In addition, there were sporadic ALK1-immunoreactive
      cells in the stratum oriens, mainly in CA1. The ALK1 expression pattern in human
      hippocampus was similar to that of rat. Pyramidal neurons within the CA2, CA3,
      and CA4 were strongly ALK1-immunoreactive in hippocampi of cognitively intact
      subjects with no neurofibrillary tangles. ALK1 signal was found in the axons of
      alveus and fimbria, and in the neuropil across CA fields. Relatively strongest
      ALK1 neuropil signal was observed in CA1 where pyramidal neurons were
      occasionally ALK1-immunoractive. As in the rat, horizontally oriented neurons in
      the stratum oriens of CA1 were both ALK1- and GAD67-immunoreactive. Analysis of
      ALK1 immunoreactivity across stages of AD pathology revealed that disease
      progression was characterized by overall reduction of the ALK1 signal in CA3 in
      advanced, but not early, stages of AD. These data suggest that the CA3 pyramidal
      neurons may remain responsive to the ALK1 ligands, e.g., BMP9, during initial
      stages of AD and that ALK1 may constitute a therapeutic target in early and
      moderate AD.

PMID- 29843237
TI  - Serum Copper is not Altered in Frontotemporal Lobar Degeneration.
AB  - Meta-analyses show copper dyshomeostasis in Alzheimer's disease. However, a study
      evaluating copper changes in other neurodegenerative forms of dementia has not
      yet been performed. In this study, we assessed copper, ceruloplasmin, copper not
      bound to ceruloplasmin, and copper to ceruloplasmin ratio in 85 patients affected
      by frontotemporal lobar degeneration (FTLD) and 55 healthy controls. Data were
      analyzed through multivariate ANOVA models taking into account age and sex as
      covariates and the stratification for FTLD variants, after calculating power
      analysis to ensure the reliability of the conclusions drawn. The study revealed
      no difference between the groups.

PMID- 29843238
TI  - Oxidative Stress in Elderly with Different Cognitive Status: My Mind Project.
AB  - BACKGROUND: Biomarkers of oxidative stress have been associated with cognitive
      status in humans and have been proposed to guide prognosis/treatment in
      Alzheimer's disease (AD) and mild cognitive impairment (MCI). OBJECTIVE: The aim
      of this study was to compare oxidative stress status in the plasma of mild
      moderate AD, MCI, and healthy elderly with normal cognition (HE) undergoing a non
      pharmacological intervention including multi-modal cognitive training ("My Mind
      Project"). METHODS: A prospective randomized trial involving 321 elderly people
      enrolled in Marche Region, Italy. Each subject was randomly assigned to an
      experimental (cognitive training) or to a control group. Cognitive performances
      and biomarkers have been analyzed before intervention (baseline), immediately
      after termination (follow-up 1), after 6 months (follow-up 2), and after 2 years
      (follow-up 3). The biological antioxidant potential (BAP) to Diacron reactive
      oxygen metabolites (d-ROM) ratio has been used as an indicator of oxidative
      stress status and as outcome variable. RESULTS: We have found no differences in
      the oxidative status among AD, MCI, and HE. Neither did we find a significant
      effect of the intervention within experimental groups. Gender was the sole factor
      with a strong significant effect on BAP/d-ROM. CONCLUSIONS: Based on these
      results, the utility of biomarkers of oxidative stress to guide
      prognosis/treatment in AD or MCI seems to be limited by lack of specificity,
      large interindividual variability, and gender bias.

PMID- 29843239
TI  - A Survey of Patient and Partner Outcome and Treatment Preferences in Mild
      Cognitive Impairment.
AB  - BACKGROUND: The patient-centered movement in health care is increasing efforts to
      design studies and interventions that address the outcomes that matter most to
      patients and their families. Research has not adequately addressed Alzheimer's
      disease patient and caregiver preferences. OBJECTIVE: To survey the outcome and
      treatment preferences of patients and caregivers who had completed a
      multicomponent behavioral intervention for mild cognitive impairment (MCI).
      METHODS: Extending prior work, we conducted an online survey regarding outcome
      and intervention preferences. Participants were patients with MCI and partners
      who completed the HABIT Healthy Action to Benefit Independence & Thinking (r)
      program. RESULTS: Both patient and partner respondents ranked patient quality of
      life as the highest priority, followed by patient self-efficacy, functional
      status, patient mood, and patient memory performance. Distressing behaviors and
      caregiver outcomes (burden, mood, and self-efficacy) had low rankings. Regarding
      the importance of HABIT (r) program components, memory compensation training was
      ranked highest and wellness education lowest by all groups. CONCLUSION:
      Additional research should compare patient preference for patient reported
      outcomes, traditional neuropsychological and clinician outcomes, and modern
      biomarker outcomes.

PMID- 29843240
TI  - Three Decades of Dementia Research: Insights from One Small Community of
      Indomitable Rotterdammers.
AB  - The most commonly encountered opening sentence in scientific publications about
      dementia undoubtedly relates to the overwhelming burden of disease. Finding an
      effective preventive or therapeutic intervention against dementia has been
      considered the most important unmet need in contemporary medicine. While efforts
      on tackling this devastating disease have increased exponentially, it is
      difficult to imagine that in the 1980s and early-1990s, the disease did not
      feature prominently on any public health report. Yet, it was already then that
      epidemiologists recognized the growing societal burden of dementia and
      rationalized that dementia is not necessarily part of aging. Indeed, the
      conviction that dementia is pathologically distinct from aging led to various
      efforts in search of unravelling its risk factors and understanding its pre
      clinical phase. Among the early pioneers, the population-based Rotterdam Study
      was initiated in 1990 clearly aiming on chronic diseases including dementia, and
      among this Alzheimer's disease, as one of its focus points. Ever since, the
      Rotterdam Study has been an important cornerstone in increasing our knowledge
      about dementia from an epidemiological perspective. Here, we summarize the main
      findings originating from this study, and put these into perspective with
      previous and current work in the field. With an expanding scope of the Rotterdam
      Study over the years, we discuss findings on occurrence, modifiable risk factors,
      imaging, and its genetic underpinnings. Importantly, we conclude with
      recommendations- or, perhaps better stated, a wish list- for future research
      which may help us reach our finish line: finding an effective preventive or
      therapeutic intervention against dementia.

PMID- 29843243
TI  - Decoupling of Local Metabolic Activity and Functional Connectivity Links to
      Amyloid in Alzheimer's Disease.
AB  - BACKGROUND: Both ongoing local metabolic activity (LMA) and corresponding
      functional connectivity (FC) with remote brain regions are progressively impaired
      in Alzheimer's disease (AD), particularly in the posterior default mode network
      (pDMN); however, it is unknown how these impairments interact. It is well known
      that decreasing mean synaptic activity of a region, i.e., decreasing LMA, reduces
      the region's sensitivity to afferent input from other regions, i.e., FC.
      OBJECTIVE: We hypothesized progressive decoupling between LMA and FC in AD, which
      is linked to amyloid-beta pathology (Abeta). METHODS: Healthy adults (n=20) and
      Abeta+patients without memory impairment (n=9), early MCI (n=21), late MCI (n=18)
      and AD (n=22) were assessed by resting-state fMRI, FDG-PET, and AV-45-PET to
      measure FC, LMA, and Abeta of the pDMN. Coupling between LMA and FC (rLA/FC) was
      estimated by voxelwise correlation. RESULTS: RLMA/FC decreased with disease
      severity (F=20.09, p<0.001). This decrease was specifically associated with pDMN
      Abeta (r=-0.273, p=0.029) but not global Abeta (r=-0.112, p=0.378) and with the
      impact of Abeta on FC (i.e., rAbeta/FC,r=-0.339; p=0.006). In multiple regression
      models rLMA/FC was also associated with memory impairment, reduced cognitive
      speed and flexibility, outperforming global Abeta, pDMN Abeta, pDMN LMA, and pDMN
      FC, respectively. CONCLUSION: Results demonstrate increasing decoupling of LMA
      from its FC in AD. Data suggest that decoupling is driven by local Abeta and
      contributes to memory decline.

PMID- 29843244
TI  - Multisensory Stimulation and Individualized Music Sessions on Older Adults with
      Severe Dementia: Effects on Mood, Behavior, and Biomedical Parameters.
AB  - BACKGROUND: Multisensory stimulation and individualized music have shown to be
      good in handling the psychological and behavioral symptoms in people with severe
      dementia. OBJECTIVE: Explore the effects of two nonpharmacological interventions,
      multisensory stimulation environment (MSSE) in a Snoezelen room and
      individualized music sessions, on mood, behavior, and biomedical parameters of
      institutionalized elderly patients with severe dementia. METHODS: Randomized
      trial of 21 patients aged >=65 years randomly assigned to two groups (MSSE and
      individualized music). Interventions administered in two-weekly sessions lasted
      30 minutes for a period of 12 weeks. Main outcomes were recorded before, during,
      and at the end of the intervention. RESULTS: Both groups had immediate positive
      effects on mood and behavior. Participants were more happy/more content (p <
      0.001), talked more spontaneously (p = 0.009), related to people better (p =
      0.002), were more attentive to/focused on their environment (p < 0.001), enjoyed
      themselves (p = 0.003), were less bored/inactive (p = 0.004), and more
      relaxed/content (p = 0.003). The MSSE group performed a better visual follow-up
      of the stimuli (p = 0.044), and the music group were more relaxed and happy (p =
      0.003). A decrease in heart rate (p = 0.013) and an increase in oxygen saturation
      (p = 0.011) were observed from before to after interventions in both groups, with
      no significant differences between them. CONCLUSIONS: Both interventions seem to
      be effective at managing mood and behavioral disturbances in the short term and
      at improving physiological rates, highlighting the efficacy of nonpharmacological
      treatments in patients with severe dementia.

PMID- 29843242
TI  - A Clinicopathological Investigation of White Matter Hyperintensities and
      Alzheimer's Disease Neuropathology.
AB  - BACKGROUND: White matter hyperintensities (WMH) on magnetic resonance imaging
      (MRI) have been postulated to be a core feature of Alzheimer's disease.
      Clinicopathological studies are needed to elucidate and confirm this possibility.
      OBJECTIVE: This study examined: 1) the association between antemortem WMH and
      autopsy-confirmed Alzheimer's disease neuropathology (ADNP), 2) the relationship
      between WMH and dementia in participants with ADNP, and 3) the relationships
      among cerebrovascular disease, WMH, and ADNP. METHODS: The sample included 82
      participants from the National Alzheimer's Coordinating Center's Data Sets who
      had quantitated volume of WMH from antemortem FLAIR MRI and available
      neuropathological data. The Clinical Dementia Rating (CDR) scale (from MRI visit)
      operationalized dementia status. ADNP+ was defined by moderate to frequent
      neuritic plaques and Braak stage III-VI at autopsy. Cerebrovascular disease
      neuropathology included infarcts or lacunes, microinfarcts, arteriolosclerosis,
      atherosclerosis, and cerebral amyloid angiopathy. RESULTS: 60/82 participants
      were ADNP+. Greater volume of WMH predicted increased odds for ADNP (p = 0.037).
      In ADNP+ participants, greater WMH corresponded with increased odds for dementia
      (CDR>=1; p = 0.038). WMH predicted cerebral amyloid angiopathy, microinfarcts,
      infarcts, and lacunes (ps < 0.04). ADNP+ participants were more likely to have
      moderate-severe arteriolosclerosis and cerebral amyloid angiopathy compared to
      ADNP-participants (ps < 0.04). CONCLUSIONS: This study found a direct association
      between total volume of WMH and increased odds for having ADNP. In patients with
      Alzheimer's disease, FLAIR MRI WMH may be able to provide key insight into
      disease severity and progression. The association between WMH and ADNP may be
      explained by underlying cerebrovascular disease.

PMID- 29843245
TI  - Platelets: Peripheral Biomarkers of Dementia?
AB  - Dementia continues to be the most burdening neurocognitive disorder, having a
      negative impact on the lives of millions. The search for biomarkers to improve
      the clinical diagnosis of dementia is ongoing, with the focus on effective use of
      readily accessible peripheral markers. In this review, we concentrate on
      platelets as biomarkers of dementia and analyze their potential as easily
      accessible clinical biomarkers for various subtypes of dementia. Current platelet
      protein biomarkers that have been investigated for their clinical utility in the
      diagnosis of dementia, in particular Alzheimer's disease, include amyloid-beta
      protein precursor (AbetaPP), the AbetaPP secretases (BACE1 and ADAM10), alpha
      synuclein, tau protein, serotonin, cholesterol, phospholipases, clusterin, IgG,
      surface receptors, MAO-B, and coated platelets. Few of them, i.e., platelet tau,
      AbetaPP (particularly with regards to coated platelets) and secreted ADAM10 and
      BACE1 show the most promise to be taken forward into clinical setting to diagnose
      dementia. Aside from protein biomarkers, changes in factors such as mean platelet
      volume have the potential to play a very specific role in both the dementia
      diagnosis and prognosis. This review raises a number of research questions for
      consideration before application of the above biomarkers to routine clinical
      setting. It is without doubt that there is a need for more clarification on the
      effects of dementia on platelet morphology and protein content before these
      changes can be clinically applied as dementia biomarkers and explored further in
      differentiating distinct dementia subtypes.

PMID- 29843247
TI  - Behavioral Assessment of Stress Compensation in Minipigs Transgenic for the
      Huntington Gene Using Cortisol Levels: A Proof-of-Concept Study.
AB  - BACKGROUND: Huntington's disease (HD) is an autosomal-dominant, progressive
      neurodegenerative disorder with motor, cognitive, behavioral and metabolic
      symptoms. HD patients exhibit an altered response to stress which is reflected in
      changes of cortisol levels. Large animal models of HD such as the Libechov
      minipig are currently explored in preclinical studies to improve translational
      reliability and assessing behavior is of interest. OBJECTIVE: This study aimed to
      investigate whether cortisol metabolism and response to stress are changed in
      minipigs transgenic for the Huntington gene (tgHD) compared to wildtype (wt)
      animals suggesting that cortisol may be used as a marker for stress in minipigs.
      METHODS: Thirty-two Libechov minipigs (14 tgHD and 18 wt) were tested before,
      during and after a stressor, i.e., a hoof trimming procedure, was applied at
      baseline and after one year. A total of six saliva samples were collected at each
      assessment and cortisol was measured. In addition, body temperature and
      respiratory rate were assessed at three pre-determined points during each hoof
      trimming procedure. RESULTS: All minipigs showed a rise of cortisol in response
      to the hoof trimming stressor similarly to cortisol changes induced by stress
      observed in humans. No relevant differences were detected between tgHD and wt
      minipigs. CONCLUSION: Cortisol testing for the assessment of stress compensation,
      e.g., during hoof trimming, is feasible and well tolerated in wt and tgHD
      minipigs. To elucidate the time profile of cortisol responses to stressors
      further studies with assessments at multiple time points and exploration of the
      diurnal profiles of cortisol in minipigs are recommended.

PMID- 29843241
TI  - The Amyloid-beta Oligomer Hypothesis: Beginning of the Third Decade.
AB  - The amyloid-beta oligomer (AbetaO) hypothesis was introduced in 1998. It proposed
      that the brain damage leading to Alzheimer's disease (AD) was instigated by
      soluble, ligand-like AbetaOs. This hypothesis was based on the discovery that
      fibril-free synthetic preparations of AbetaOs were potent CNS neurotoxins that
      rapidly inhibited long-term potentiation and, with time, caused selective nerve
      cell death (Lambert et al., 1998). The mechanism was attributed to disrupted
      signaling involving the tyrosine-protein kinase Fyn, mediated by an unknown toxin
      receptor. Over 4,000 articles concerning AbetaOs have been published since then,
      including more than 400 reviews. AbetaOs have been shown to accumulate in an AD
      dependent manner in human and animal model brain tissue and, experimentally, to
      impair learning and memory and instigate major facets of AD neuropathology,
      including tau pathology, synapse deterioration and loss, inflammation, and
      oxidative damage. As reviewed by Hayden and Teplow in 2013, the AbetaO hypothesis
      "has all but supplanted the amyloid cascade." Despite the emerging understanding
      of the role played by AbetaOs in AD pathogenesis, AbetaOs have not yet received
      the clinical attention given to amyloid plaques, which have been at the core of
      major attempts at therapeutics and diagnostics but are no longer regarded as the
      most pathogenic form of Abeta. However, if the momentum of AbetaO research
      continues, particularly efforts to elucidate key aspects of structure, a clear
      path to a successful disease modifying therapy can be envisioned. Ensuring that
      lessons learned from recent, late-stage clinical failures are applied
      appropriately throughout therapeutic development will further enable the
      likelihood of a successful therapy in the near-term.

PMID- 29843246
TI  - Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous
      Huntington's Disease Knock-In Mouse Models.
AB  - BACKGROUND: Huntington's disease (HD) is a progressive neurodegenerative disorder
      associated with aging, caused by an expanded polyglutamine (polyQ) repeat within
      the Huntingtin (HTT) protein. In HD, degeneration of the striatum and atrophy of
      the cortex are observed while cerebellum is less affected. OBJECTIVE: To test the
      hypothesis that HTT protein levels decline with age, which together with HTT
      mutation could influence disease progression. METHODS: Using whole brain cell
      lysates, a unique method of SDS-PAGE and western analysis was used to quantitate
      HTT protein, which resolves as a monomer and as a high molecular weight species
      that is modulated by the presence of transglutaminase 2. HTT levels were measured
      in striatum, cortex and cerebellum in congenic homozygous Q140 and HdhQ150 knock
      in mice and WT littermate controls. RESULTS: Mutant HTT in both homozygous knock
      in HD mouse models and WT HTT in control striatal and cortical tissues
      significantly declined in a progressive manner over time. Levels of mutant HTT in
      HD cerebellum remained high during aging. CONCLUSIONS: A general decline in
      mutant HTT levels in striatum and cortex is observed that may contribute to
      disease progression in homozygous knock-in HD mouse models through reduction of
      HTT function. In cerebellum, sustained levels of mutant HTT with aging may be
      protective to this tissue which is less overtly affected in HD.

PMID- 29843248
TI  - Human Immunodeficiency Virus Infection in Huntington's Disease is Associated with
      an Earlier Age of Symptom Onset.
AB  - BACKGROUND: Huntington Disease (HD) and human immunodeficiency virus (HIV) are
      both associated with neurodegeneration in the cerebral cortex and striatum. The
      rate of striatal degeneration is a known predictor of symptom onset in HD
      indicating a potential neurobiological link between HD and HIV. OBJECTIVE: To
      determine if the presence of pre-existing HIV infection would trigger a
      significantly earlier age of symptom onset (ASO) in HD-mutation carriers when
      compared to non-infected HD subjects. METHODS: This was a retrospective analysis
      of the Enroll-HD database that included participants with a CAG repeat of at
      least 36. Participants with HD and a comorbidity of HIV that was diagnosed prior
      to their reported ASO were identified and compared to participants with HD who
      did not have HIV. An ANCOVA analysis was performed to investigate the differences
      in ASO between the HIV and non-HIV groups. Sex, drug use, and CAG repeat number
      were used as covariates. RESULTS: The average ASO of HD subjects with previous
      HIV infection (n = 8) was 9.1 years earlier than non-HIV infected HD subjects (n
      = 3259) [F (1, 3267) =10.05, p = 0.002]. Despite low numbers of participants in
      the HIV group, the calculated effect size of this difference was 1.07.
      CONCLUSION: The known neurobiological changes caused by HIV seem to hasten the
      ASO in patients with HD. These results may enhance our understanding of the
      neuropathology of HD in a way that will help with the identification of novel
      targets for future therapies.

PMID- 29843249
TI  - Circadian Rhythm, Cognition, and Mood Disorders in Huntington's Disease.
AB  - BACKGROUND: Sleep disturbances are an early and prominent feature of Huntington's
      disease (HD). OBJECTIVE: The current study investigated the relation between
      sleep quality impairment and cognitive and psychiatric symptoms in patients with
      HD. METHODS: Sleep quality, daytime sleepiness, and neurocognitive symptoms were
      assessed in 38 mutation carriers (23 premanifest and 15 early stage) and 38 age
      and sex-matched controls using standardized questionnaires (the Pittsburgh Sleep
      Quality Index, Epworth Sleepiness Scale, the cognitive section of the Unified
      Huntington's Disease Rating Scale, the Hospital Anxiety and Depression Scale, and
      the Irritability Scale). RESULTS: Compared to controls, HD patients had worse
      sleep quality (p = 0.016), which was associated with more severe cognitive
      impairment and higher anxiety, depression and irritability scores. These findings
      suggest that HD patients may have a delayed sleep phase, as indicated by the
      increased sleep onset latency (p = 0.019) and later wake-up time (0.013), which
      was associated with worse cognitive performance and greater depressive and
      anxiety symptoms. CONCLUSIONS: Our data provide further evidence for an
      association between sleep quality in HD and cognitive performance and psychiatric
      symptoms.

PMID- 29843250
TI  - Huntington's Disease Outpatient Clinic for Functional Diagnosis and Treatment:
      Coming to Consensus: How Long Term Care Facility Procedures Complement Specialist
      Diagnosis and Treatment.
AB  - Huntington's disease (HD) patients and families deserve expert treatment and care
      throughout their lives, but uniformity in functional diagnosis and treatment was
      lacking. In the aim of reaching this uniformity on day-to-day treatment and care
      offered by multidisciplinary outreach teams from Dutch long term care facilities
      for ambulatory HD patients, a consensus trajectory was started to harmonise our
      care programme with international standards and within the country. The consensus
      statements, given as supplementary material, should lead to expert treatment and
      care for HD families throughout the Netherlands and this manuscript should
      contribute and revitalise a global discussion on standards of treatment and care.

PMID- 29843251
TI  - Cognitive Impairment and Mortality in a Population-Based Parkinson's Disease
      Cohort.
AB  - BACKGROUND: Parkinson's disease (PD) is a heterogeneous disorder with variability
      in phenotype and progression. OBJECTIVE: We describe characteristics of PD
      patients in the largest population-based cohort followed for progression to date,
      and evaluate clinical risk factors for cognitive impairment and mortality.
      METHODS: We collected longitudinal data using the Unified Parkinson's Disease
      Rating Scale (UPDRS), Mini-Mental State Exam (MMSE), and Geriatric Depression
      Scale (GDS) in 242 new-onset PD patients followed for progression. We compared
      those who developed cognitive impairment (MMSE<=24) with those who did not, using
      t-tests, chi-square tests, and Cox proportional hazards regression. Mortality
      risk factors were assessed in all 360 patients enrolled at baseline. RESULTS:
      Thirty-four patients developed cognitive impairment during follow-up. Baseline
      characteristics predictive of faster time to cognitive impairment were older age
      at diagnosis, fewer years of education, and longer average sleep duration
      reported. The 197 patients who died were older at diagnosis, reported longer
      average sleep duration, had lower baseline MMSE scores, higher UPDRS-III scores,
      and a higher proportion were of the postural instability gait difficulty (PIGD)
      subtype. Patients with the tremor dominant (TD) subtype at baseline were less
      likely to develop cognitive impairment or die during follow-up. Progression of
      cognitive, depressive, and motor symptoms occurred in parallel. CONCLUSIONS:
      Motor symptom severity and subtype influence the incidence of cognitive
      impairment and mortality in PD, with the TD motor subtype being relatively
      protective. In addition, we newly found that longer average sleep duration at
      baseline predicts faster progression to cognitive impairment and mortality.

PMID- 29843252
TI  - The Effect of Short Pulse Width Settings on the Therapeutic Window in Subthalamic
      Nucleus Deep Brain Stimulation for Parkinson's disease.
AB  - BACKGROUND: Subthalamic nucleus deep brain stimulation (STN-DBS) is an
      established treatment for selected Parkinson's disease (PD) patients, but therapy
      is often limited by side effects. Previous studies indicate an inverse
      relationship of the therapeutic window (TW) to pulse width (PW) settings down to
      60MUs, but there is limited data available on the effect of shorter PWs.
      OBJECTIVE: To define the TW of STN-DBS in PD at PW of 30MUs (PW30) relative to
      standard PW settings at 60MUs (PW60), and to compare speed of gait and speech
      intelligibility on the two PW conditions. METHODS: Monopolar review data of 15
      consecutive PD patients who had screening of contacts performed at PW60 and PW30
      was used to calculate the TW at each contact. We compared the TWs of the most
      efficacious contact per STN, and a secondary analysis was performed comparing all
      contacts. Speed of gait with a timed 10 metre walk test, speech intelligibility,
      and perceptual characteristics of speech were also compared at the efficacy
      thresholds for PW60 and PW30. RESULTS: The TW was significantly greater at PW30
      [3.8+/-1.6mA] than at PW60 [1.7+/-1.1mA]. In the secondary analysis, 110 TWs
      could be calculated and these remained significantly higher at PW30. The timed 10
      metre walk at PW30 was faster than at PW60, and perceptual rating scores of
      speech were significantly improved at PW30. CONCLUSIONS: STN-DBS in PD patients
      using a PW of 30MUs significantly increases the TW compared to standard PW
      settings, and this effect is consistent across all contacts of an electrode.
      Speed of gait and perceptual speech scores are also improved at 30MUs settings.

PMID- 29843253
TI  - Cardinal Motor Features of Parkinson's Disease Coexist with Peak-Dose Choreic
      Type Drug-Induced Dyskinesia.
AB  - BACKGROUND: Clinical and anecdotal observations propose that patients with
      Parkinson's disease (PD) may show drug-induced dyskinesia (DID) concomitantly
      with cardinal motor features. However, the extent of the concomitant presence of
      DID and cardinal features remains to be determined. OBJECTIVES: This cross
      sectional study measured peak-dose choreic-type DID in a quantitative manner in
      patients diagnosed with PD, and determined whether symptoms such as tremor,
      bradykinesia, rigidity, postural instability or freezing of gait (FoG) were still
      detectable in these patients. METHODS: 89 patients diagnosed with PD were
      recruited and assessed using a combination of quantitative measures using
      inertial measurement units to capture DID, tremor, bradykinesia, and FoG.
      Clinical evaluations were also used to assess rigidity and postural instability.
      Motor symptoms of PD were assessed 3 times during the testing period, and a
      series of activities of daily living were repeated twice, in between clinical
      tests, during which the level of DID was quantified. Peak-dose was identified as
      the period during which patients had the highest levels of DID. Levels of tremor,
      rigidity, bradykinesia, postural instability, and FoG were used to determine the
      percentage of patients showing these motor symptoms simultaneously with DID.
      RESULTS: 72.4% of patients tested presented with measurable DID during the
      experiment. Rest, postural and kinetic tremor (12.7% , 38.1% , and 15.9%
      respectively), bradykinesia (28.6% ), rigidity (55.6% ), postural instability
      (71.4% ) and FoG (9.5% ) were detected simultaneously with DID. CONCLUSIONS: PD
      symptomatology remains present in patients showing peak-dose choreic-type DID,
      illustrating the challenge facing physicians when trying to avoid dyskinesia
      while attempting to alleviate motor symptoms.

PMID- 29843254
TI  - What Effects Might Exenatide have on Non-Motor Symptoms in Parkinson's Disease: A
      Post Hoc Analysis.
AB  - BACKGROUND: Exenatide is a GLP-1 receptor agonist that was recently studied for
      potential disease-modifying effects in a randomised, placebo-controlled clinical
      trial in patients with moderate stage Parkinson's disease, and showed positive
      effects on the motor severity of the disease which were sustained 12 weeks beyond
      the period of exenatide exposure. Analysis of pre-defined secondary outcomes
      revealed no statistically significant differences between patients treated with
      exenatide in total non-motor symptom burden and overall quality of life measures.
      OBJECTIVE: The response of individual non-motor symptoms to an intervention may
      vary and thus this post hoc analysis was conducted to explore the possible
      effects of exenatide compared to placebo on individual non-motor symptoms.
      RESULTS: Compared to placebo, patients treated with exenatide-once weekly had
      greater improvements in individual domains assessing mood/depression across all
      observer-rated outcome measures after 48 weeks including the "mood/apathy" domain
      of the NMSS, - 3.3 points (95% CI - 6.2, - 0.4), p = 0.026; the "mood" score
      (Q1.3+Q1.4 of the MDS-UPDRS Part 1), - 0.3 points (95% CI - 0.6, - 0.1), p =
      0.034; and a trend in the MADRS total score, - 1.7 points (95% CI - 3.6, 0.2), p
      = 0.071. In addition, there was an improvement in the "emotional well-being"
      domain of the PDQ-39 of 5.7 points ((95% CI - 11.3, - 0.1), p = 0.047 though
      these improvements were not sustained 12 weeks after exenatide withdrawal. At 48
      weeks these changes were of a magnitude that would be subjectively meaningful to
      patients and were not associated with changes in motor severity or other factors,
      suggesting exenatide may exert independent effects on mood dysfunction.
      CONCLUSIONS: These exploratory findings will contribute to the design of future
      trials to confirm the extent of motor and non-motor symptom effects of exenatide
      in larger cohorts of patients.

PMID- 29843255
TI  - Underutilization of the reports of adverse events in an Argentine hospital.
AB  - BACKGROUND: An adverse event is defined as any unintentional harm that results in
      temporary or permanent disability and/or prolongation of hospitalization time, or
      death of a patient; as a consequence of health care provided by any staff member
      of the health institution. OBJECTIVES: The aim was to describe the adverse events
      that affect patient safety, reported in 2015 in a private hospital in the city of
      Cordoba, Argentina. METHODS: We analyzed 678 events reported through the computer
      system on the hospital's intranet. RESULTS: The highest frequency of events
      reported corresponded to the nursing professionals (40.7% ). Problems related to
      drug therapy process showed the highest frequency of reports (17.7% ), followed
      by communication failures (11.1% ) and patient's fall (10.3% ). In the
      notification of the causes of the incident, 51.9% of "No answer" was observed.
      CONCLUSION: In the case of this hospital, this valuable tool is being
      underutilized. The reports should allow identifying the entire chain of events
      that lead to the incidents to address effective interventions in patient safety
      that involve all hospital staff, with greater emphasis on senior staff.

PMID- 29843256
TI  - Developing a model for hospital inherent safety assessment: Conceptualization and
      validation.
AB  - BACKGROUND: Paying attention to the safety of hospitals, as the most crucial
      institute for providing medical and health services wherein a bundle of
      facilities, equipment, and human resource exist, is of significant importance.
      OBJECTIVE: The present research aims at developing a model for assessing
      hospitals' safety based on principles of inherent safety design. METHODS: Face
      validity (30 experts), content validity (20 experts), construct validity (268
      examples), convergent validity, and divergent validity have been employed to
      validate the prepared questionnaire; and the items analysis, the Cronbach's alpha
      test, ICC test (to measure reliability of the test), composite reliability
      coefficient have been used to measure primary reliability. The relationship
      between variables and factors has been confirmed at 0.05 significance level by
      conducting confirmatory factor analysis (CFA) and structural equations modeling
      (SEM) technique with the use of Smart-PLS. RESULTS: R-square and load factors
      values, which were higher than 0.67 and 0.300 respectively, indicated the strong
      fit. Moderation (0.970), simplification (0.959), substitution (0.943), and
      minimization (0.5008) have had the most weights in determining the inherent
      safety of hospital respectively. CONCLUSIONS: Moderation, simplification, and
      substitution, among the other dimensions, have more weight on the inherent
      safety, while minimization has the less weight, which could be due do its
      definition as to minimize the risk.

PMID- 29843257
TI  - The Monsanto Papers: Poisoning the scientific well.
AB  - OBJECTIVE: Examination of de-classified Monsanto documents from litigation in
      order to expose the impact of the company's efforts to influence the reporting of
      scientific studies related to the safety of the herbicide, glyphosate. METHODS: A
      set of 141 recently de-classified documents, made public during the course of
      pending toxic tort litigation, In Re Roundup Products Liability Litigation were
      examined. RESULTS: The documents reveal Monsanto-sponsored ghostwriting of
      articles published in toxicology journals and the lay media, interference in the
      peer review process, behind-the-scenes influence on retraction and the creation
      of a so-called academic website as a front for the defense of Monsanto products.
      CONCLUSION: The use of third-party academics in the corporate defense of
      glyhphosate reveals that this practice extends beyond the corruption of medicine
      and persists in spite of efforts to enforce transparency in industry
      manipulation.

PMID- 29843258
TI  - Hemodynamic instability associated with increased risk of death or brain injury
      in neonates with hypoxic ischemic encephalopathy.
AB  - OBJECTIVE: To determine the association between hemodynamic instability requiring
      inotropes and brain injury or death in neonates with hypoxic ischemic
      encephalopathy (HIE). METHODS: Retrospective cohort study of 221 neonates with
      HIE. Brain injury was defined using four HIE patterns based on MRI diffusion or
      T1 changes. The primary outcome was death or brain injury. Secondary outcomes
      were abnormal MRI, death, and abnormal EEG. Logistic regression was used to
      examine the risk of death or brain injury with the use of inotropes while
      adjusting for confounding factors. RESULTS: Brain injury or death occurred more
      often in neonates who received inotropes (71.1%, 69/97) compared to those who did
      not (44.3%, 55/124). The use of inotropes was associated with increased risk of
      death or brain injury (OR 3.11; 95% CI 1.39-7.004) and abnormal MRI (OR 2.78; 95%
      CI 1.22-6.34) after adjusting for confounding factors. Mortality was
      significantly higher in neonates exposed to inotropes (21.6%, 21/97) compared
      with those who did not receive inotropes (4%, 5/124), P < 0.001. CONCLUSION: In
      infants with HIE, hemodynamic instability requiring inotropes in the first 72
      hours of life was associated with increased risk of death or brain injury
      detected by MRI.

PMID- 29843259
TI  - Unusual complication of fulminant congenital cytomegalovirus infection.
AB  - Persistent pulmonary hypertension of newborn (PPHN) is a very rare manifestation
      of congenital cytomegalovirus (CMV) infection. PPHN associated with CMV can be
      severe but is usually transient and responds well to antiviral therapy. We report
      a rare case of PPHN that occurred in the setting of fulminant congenital CMV
      infection and successful treatment with antiviral therapy along with review of
      the very few cases reported in literature. A male appropriate for gestational Age
      (AGA) newborn developed rapidly progressive respiratory distress starting at 11
      hours of life requiring ventilatory support and 100% oxygen. He developed
      hypotension and wide difference between pre and postductal saturations.
      Echocardiography revealed findings consistent with severe PPHN. Examination also
      revealed multiple purpuric skin lesions and soft hepatosplenomegaly. MRI Brain
      showed intraventricular hemorrhage, bilateral periventricular calcification,
      bilateral cerebral and cerebellar intraparenchymal hemorrhage. Complete Cell
      Count (CBC) revealed severe thrombocytopenia and blood serum showed positive
      Immunoglobulin M (IgM) for CMV and Urinary CMV was positive by nucleic acid test.
      He was treated with ganciclovir, inhaled nitric oxide and inotropes. He recovered
      and was discharged on day 24 of life. Severe PPHN is a rare manifestation of
      congenital CMV infection and carries a high risk of morbidity and mortality.
      Congenital CMV should be considered in neonates with PPHN of unknown etiology.
      Early institution of antiviral therapy in these babies is associated with
      favorable outcome.

PMID- 29843260
TI  - Is Breast Best? Examining the effects of alcohol and cannabis use during
      lactation.
AB  - Maternal drug use during lactation may have adverse effects on the health of
      their children. Two common drugs used during this period are alcohol and
      cannabis. A literature search was conducted using PubMed, CINAHL, Nursing and
      Allied Health, and Google Scholar with the following search terms: marijuana,
      cannabis, THC, alcohol, ethanol, breastfeeding, lactation, and breastmilk. The
      search strategy was restricted to papers since the year 2000, and limited to
      English language journals. Reference lists were also used to capture any articles
      that were missed from the database searches. In total, 19 articles were found
      related to alcohol and breastfeeding (n = 17 original research papers; n = 2
      systematic reviews), and 4 articles were specific to cannabis (n = 2 original
      papers; n = 2 systematic reviews). The most common outcomes associated with
      alcohol consumption and breastfeeding included changes in sleep patterns, reduced
      milk production and flow, lower milk intake, and impaired immune function.
      Maternal outcomes related to cannabis consumption included panic attacks, delayed
      response time, increased heart rate, reduced short-term memory, dizziness, and
      impaired motor performance; infant outcomes associated with maternal cannabis use
      and breastfeeding were reduced muscular tonus, poor sucking, and growth delay and
      restriction. Mothers should be advised to refrain from substance use during the
      lactation period for the health and safety of their children.

PMID- 29843261
TI  - Analysis of clinical diagnosis for all patients receiving antenatal betamethasone
      in a community hospital.
AB  - OBJECTIVE: Identify which obstetrical diagnoses are associated with suboptimal
      antenatal betamethasone administration. METHODS: We present a retrospective,
      cohort study of patients who received betamethasone due to a risk for preterm
      delivery, between 7/2013 and 9/2016 at our institution. Details of betamethasone
      administration were recorded including the diagnosis leading to betamethasone.
      Optimal administration was defined as two doses of betamethasone given 24 hours
      apart, with delivery occurring at greater than 24 hours but less than seven days
      after completion of the second dose of betamethasone. Suboptimal administration
      included any betamethasone dosing that did not meet the optimal criteria.
      RESULTS: 428 patients were identified for the study with 20.1% of patients
      receiving optimal betamethasone. Patients presenting with hypertensive disorders
      of pregnancy (36.1%) and preterm premature rupture of membranes (PPROM) (22.1%)
      were more likely to receive optimal betamethasone, while patients presenting with
      preterm labor (PTL) (41.8%) and placental abruption (24.6%) were more likely to
      receive suboptimal betamethasone (p-value < 0.0001). Among PTL patients, those
      presenting with contractions and cervical dilation/short cervix (19.15%) were
      more likely to receive optimal betamethasone (p-value 0.0349). Optimal
      betamethasone decreased the incidence of respiratory distress syndrome (RDS)
      among 32.1 to 34 week neonates. CONCLUSION: Hypertensive disorders of pregnancy
      and PPROM are associated with optimal betamethasone, whereas PTL and placental
      abruption are associated with suboptimal betamethasone.

PMID- 29843262
TI  - The perception of pre- and post-natal marijuana exposure on health outcomes: A
      content analysis of twitter messages.
AB  - The prevalence of marijuana use during pregnancy ranges from 3- 30% , and most of
      this is for recreational purposes. Marijuana exposure during pregnancy has been
      linked with low birth weight babies and other adverse child health outcomes.
      Twitter is a popular news and social networking outlet, and is frequently used to
      access information about population health and behavior. The primary objective of
      this study was to investigate the types of messages disseminated on Twitter about
      marijuana use and infant and maternal health. The secondary objective was to
      describe the reported health outcomes associated with prenatal and postnatal
      marijuana use. Tweets were collected from the inception of Twitter (2006) until
      April 2017. If tweets included links, these links were examined to investigate
      the source of the message and to clarify the user's intent. In total, 550 tweets
      were captured, with most tweets (77.6%) having a neutral tweet tone, suggesting
      uncertainty about the health effects associated with pre- and post-natal
      marijuana exposure. The sources attached to the original tweets, however, were
      more likely to report on negative health outcomes. The most common health
      outcomes associated with prenatal marijuana exposure were: poor brain development
      (27.3%), inadequate development of the nervous system (23.6%), low birth weight
      (23.3%), poor behavioral outcomes (21.0%), and infant memory issues (19.3%). The
      inverse association between marijuana use and the quality and quantity of milk
      produced by the mother was the most commonly reported tweet for the lactation
      period.

PMID- 29843263
TI  - Successful exchange transfusion in extremely preterm infant after symptomatic
      lipid overdose.
AB  - BACKGROUND: Complications of intravenous lipid administration are relatively
      uncommon. However, inadvertent rapid infusion of intravenous fat emulsion (IVFE)
      is an inherent risk when fats are infused separately from the dextrose-amino acid
      solution. CASE REPORT: Extremely preterm infant, born at 25 weeks and 6 days of
      gestational age weighing 920 g, who inadvertently received a massive overdose of
      IVFE due to a device failure. He developed lethargy, apnea, metabolic acidosis
      and hemodynamic instability requiring mechanical ventilation and inotropic
      support. Despite discontinuation of IVFE and supportive care, clinical course and
      metabolic acidosis worsened, so a double-volume exchange transfusion was
      performed. The procedure was well tolerated, without complications. Serum
      triglyceride concentration as well as other laboratory data normalized
      immediately after the exchange transfusion. The patient was extubated to
      continuous positive airway pressure and inotropic support was discontinued 24
      hours after the procedure. He was discharged home at 40 weeks of corrected age
      with normal magnetic resonance imaging and neurological examination. CONCLUSION:
      In cases of profound, symptomatic hypertriglyceridemia due to lipid overdose,
      double-volume exchange transfusion should be considered, even in extremely
      preterm infants.

PMID- 29843264
TI  - A rare case of fetal extensive intracranial hemorrhage and whole-cerebral
      hypoplasia due to latent maternal vitamin K deficiency.
AB  - We present here a late preterm infant with extensive brain lesions resulting from
      vitamin K deficiency. A female infant was born after 35 weeks of gestation by
      emergent cesarean section because of non-reassuring fetal status. Her mother had
      severe eating disorder and recurrent vomiting since early pregnancy. She was
      immediately intubated and ventilated because she was extremely pale, hypotonic,
      and non-reactive. Cerebral magnetic resonance imaging immediately after birth
      showed intraparenchymal hemorrhage in the left frontal lobe and cerebellum,
      marked cerebral edema, and cerebellar hypoplasia. Coagulation studies of the
      infant showed hepaplastin test <5%, prolonged PT and APTT, and a marked elevation
      of protein induced by vitamin K absence or antagonist-II. This case highlighted a
      potential risk of intracranial bleeding due to maternal vitamin K deficiency and
      difficulty in its prediction before delivery. Vitamin K supplementation to high
      risk mothers might be indispensable for preventing severe fetal vitamin K
      deficiency. Even when coagulation studies in mothers is normal, it is imperative
      to provide vitamin K supplementation for total protection.

PMID- 29843265
TI  - Risk factors of stillbirth in Yemen.
AB  - BACKGROUND: Yemen has the highest stillbirth rate among the Arab countries.
      However, the risk factors of this high rate are lacking. This study aimed to
      determine the maternal, newborn, and service related risk factors for stillbirths
      at the main maternity hospital in Sana'a city. METHODS: A case-control study was
      conducted in the main maternity hospital in Sana'a city, Yemen. Case and controls
      were selected prospectively during the study period. Cases were women who
      delivered stillbirths after 24 weeks of gestation. Risk factors data for mothers
      and their neonates were collected using face-to-face interview and data
      abstraction from medical records. RESULTS: The study included 101 women with
      stillbirths and 202 women with singleton live births. Mothers older than 35 years
      (Odds ratio (OR) = 4.9) and those with low level of education were significantly
      more likely to give stillbirths. Prolonged labor (OR = 5.8), mothers' anemia (OR
      = 2.1), less than 4 antenatal visits (OR = 5.1) and meconium stained amniotic
      fluid (OR = 11.5) were significantly associated with increased odds of
      stillbirth. Prematurity (OR = 27), umbilical complications (OR = 6.4), low birth
      weight (OR = 17.7), and congenital complications (OR = 40.6) were significantly
      associated with higher odds of stillbirths. CONCLUSIONS: This study identified
      many risk factors of stillbirth that are amenable to intervention. Encouraging
      women to deliver at health facilities, providing better management of obstetrical
      complications, proper antenatal care, and prompt referral services are essential
      for reduction of stillbirths in Yemen.

PMID- 29843266
TI  - Correlation of maternal A1c with glucose infusion rate requirements in the
      newborn.
AB  - OBJECTIVE: Fetal hyperinsulinemia and neonatal hyperglycemia are complications of
      poor maternal glycemic control and may result in increased glucose infusion rate
      (GIR) requirements in infants of diabetic mothers (IDMs). The objectives of this
      study were to correlate maternal A1c levels with GIR requirements in IDMs,
      establish an A1c threshold predictive for GIR requirements, and identify
      associations between A1c levels and complications in IDMs. STUDY DESIGN: A
      retrospective review of paired maternal A1c values and GIR requirements of IDMs
      were compared via logistic regression analysis. A likelihood ratio was calculated
      to correlate A1c levels with GIR requirements, and identify a maternal A1c
      threshold. RESULTS: Increasing A1c values were significantly correlated with
      GIR>=5 mg/kg/min (OR, 1.37; 95% CI 1.04-1.79, p = 0.021). Macrosomia was the most
      frequent complication (OR, 1.31; 95% CI 1.04-1.67, p = 0.022) and A1c > 6.8% was
      predictive for increased GIR requirements. CONCLUSION: Increased A1c values were
      significantly associated with GIR requirements>=5 mg/kg/min. Increased maternal
      A1c is significantly associated with complications in newborns, specifically
      macrosomia. A maternal A1c of 6.8% was identified as a threshold predictive of
      increased GIR requirements.

PMID- 29843267
TI  - Impact of a neuro-intensive care service for newborns.
AB  - BACKGROUND: Advances in treating the injured neonatal brain have given rise to
      neuro-intensive care services for newborns. This study assessed the impact of one
      such service in a cohort of newborns treated with therapeutic hypothermia.
      METHODS: Our newborn neuro-intensive care service was started in November 2012.
      From January 2008 to October 2016, a cohort of 158 newborns was treated with
      therapeutic hypothermia, 29 before and 129 after the inception of the service.
      This study compared the outcomes of newborns treated by the service with those of
      newborns treated before. Multivariate regression analysis associating length-of
      stay and treatment pre- or post-service was adjusted for five-minute Apgar score,
      time-to-target temperature, seizures, and mortality. RESULTS: The neuro-intensive
      care service was also associated with a decrease in mortality (17% before service
      to 5.4% with the service, p = 0.03), though this association is likely
      multifactorial and reflects the application of therapeutic hypothermia to a wider
      variety of patients. However, the service was independently associated with
      decreased length-of-stay (mean 22 pre-service to 13 days with the service, p <
      0.0005.)CONCLUSIONS:The service educated referring hospitals in recognizing
      therapeutic hypothermia candidates, which increased the number of treated
      newborns, and created a number of procedures to streamline the delivery of
      treatment. While the increasing number and variety of patients treated could
      spuriously reduce length-of-stay, length-of-stay was still significantly reduced
      after adjustment, providing evidence that neuro-intensive care services for
      newborns can improve hospital outcomes.

PMID- 29843268
TI  - Occult large epidural hemorrhage in a newborn infant after in-hospital fall.
AB  - Management of newborn infants fell in-hospital is especially challenging given
      the limited signs and symptoms of intracranial hemorrhage in this age group. We
      present a case of a four day old well appearing newborn infant found to have a
      severe epidural hemorrhage requiring emergent surgical drainage. Development of
      imaging protocols for newborn infants suffering in-hospital falls need to
      consider the potential consequences of missing actionable intracranial hemorrhage
      when relying on clinical observation as a management strategy.

PMID- 29843269
TI  - Bronchopulmonary dysplasia appropriateness as a surrogate marker for long-term
      pulmonary outcomes: A Systematic review.
AB  - BACKGROUND: Bronchopulmonary dysplasia (BPD) is used to clinically describe the
      severity of lung disease and to serve as a common surrogate endpoint for long
      term pulmonary morbidity in clinical trials, but its performance as a surrogate
      end-point warrants evaluation. Our objective was to assess real-world performance
      of BPD as a surrogate marker for long-term pulmonary outcomes. METHODS: We
      performed a systematic review of large, multi-centered, blinded, randomized
      control trials to evaluate the use of BPD as a surrogate marker for long-term
      pulmonary outcomes. Long-term pulmonary outcomes occurred within two years and
      included measures of hospital utilization, respiratory illness, respiratory
      medication, and mortality. Direction and magnitude of effect were evaluated using
      number needed to treat analysis. RESULTS: Five studies were included in our
      review. Studies varied in definition of BPD and in long-term outcomes measured.
      Only one study found a significant, consistent risk reduction in both BPD and any
      long-term pulmonary outcome. Two studies found significant reductions in long
      term pulmonary outcomes with a non-significant reduction in BPD. CONCLUSIONS: BPD
      is an imperfect surrogate marker for long-term pulmonary outcomes. It did not
      consistently predict the magnitude or direction of the effect of an intervention
      on longer-term pulmonary outcomes. Furthermore, there was significant variation
      in the definitions of BPD and in the long-term pulmonary outcomes used. There is
      a need for future work to identify more predictive surrogate markers and a need
      for better standardization of assessments of long-term pulmonary outcomes.

PMID- 29843270
TI  - Effect of probiotics on C-reactive protein levels in preterm infants: Secondary
      analysis of a randomized controlled trial.
AB  - BACKGROUND: Excessive inflammation is associated with adverse outcomes in preterm
      infants. C- reactive protein (CRP) is a marker of inflammation/infection.
      Probiotics have anti-inflammatory properties. Randomized controlled trials (RCTs)
      in preterm infants have not reported effect of probiotics on CRP. AIM: To
      evaluate effect of probiotics on CRP in preterm infants who had participated in a
      RCT of Bifidobacterium breve (B. breve) m-16v. METHODS: Data on all infants (GA
      <33 weeks, n = 159) enrolled in the RCT was analyzed. For study purpose, CRP <15
      mg/L and <=10 mg/L was considered normal for the first week, and thereafter
      respectively. Mixed logistic regression modelling was used to assess probiotic
      effect on CRP levels. RESULTS: There were 1579 CRP measurements (Probiotic: 851
      vs. Placebo: 728). Baseline characteristics and number [Median (IQR)] of CRP
      estimations per infant [l0 (5, 20) vs. 10 (6, 17), p = 0.861] were comparable
      between probiotic vs. placebo group. There was no significant difference in the
      proportion of infants with high CRP over time (treatment by weekly time points
      interaction, p = 0.187), and across all time points between probiotic and placebo
      group (adjusted OR: 1.62, 95% CI: 0.91-2.88, p = 0.102)CONCLUSION:B. breve m-16v
      did not decrease CRP levels in preterm infants born <33 weeks.

PMID- 29843271
TI  - Early prediction of a significant patent ductus arteriosus in infants <32 weeks
      gestational age.
AB  - BACKGROUND: The optimal thresholds for identification of preterm infants at
      greatest risk for adverse sequelae related to patent ductus arteriosus have not
      been well delineated. Our aim was to determine hemodynamic parameters in the
      first 24 hours using continuous non-invasive vital and structural measurements to
      predict which infants required PDA treatment in our institution. METHODS:
      Retrospective secondary analysis of data from infants born 23 to 32 weeks
      gestational age with cardiac output and stroke volume via electrical cardiometry,
      cerebral tissue oximetry measurements, mean arterial blood pressure (BP), heart
      rate, and oxygen saturation and functional echocardiography results at 12 hours
      of life were recorded when available (93 percent of subjects). RESULTS: A total
      of 292 infants, of which 55 (26+/-2 weeks, 862+/-268 grams) were treated for PDA.
      Treated infants demonstrated increased left ventricular output (p < 0.001) and
      lower mean BP (p = 0.010). The optimal area under the receiver operating
      characteristic curve (AUC) for predicting PDA treatment in our all gestations
      cohort is a mean BP at 15 hours of life of <33 mm Hg (AUC = 0.854, p < 0.001, 95%
      CI 0.792, 0.916). For infants <28 weeks a mean BP at 13 hours of life of <33 mm
      Hg (AUC = 0.741, p < 0.050, 95% CI 0.642, 0.839). CONCLUSIONS: In our cohort
      increased left ventricular output and lower mean BP predicted a clinically
      significant PDA requiring treatment.

PMID- 29843272
TI  - Slow enteral feeding decreases risk of transfusion associated necrotizing
      enterocolitis.
AB  - BACKGROUND: Necrotizing Enterocolitis (NEC) is a multifactorial condition where
      PRBC transfusion is associated with necrotizing enterocolitis (TANEC) in about a
      third of all cases of NEC. We have investigated the role of feeding practices in
      incidence of TANEC. We sought to compare infants diagnosed with TANEC versus
      infants diagnosed with classic NEC and investigated the effects of a standardized
      slow enteral feeding (SSEF) protocol on TANEC incidence as well as the effects of
      SSEF on growth of infants with NEC. METHODS: We conducted a retrospective cohort
      study, where medical records of infants born in a tertiary care neonatal
      intensive care unit (level IIIb) from January 1997 to May 2014 with birth weight
      < 1500 grams and gestational age<=34 weeks with NEC stage IIa or greater
      according to the modified Bell's staging were reviewed. RESULTS: During the study
      period, 111 infants developed NEC, and 41/111 (37%) were diagnosed with TANEC.
      Infants with TANEC were smaller, more premature, had higher SNAPPE scores and
      were more anemic prior to transfusion compared with infants with 'classic NEC'.
      The severity of NEC did not differ between the two groups, however, infants with
      TANEC had worse outcomes and longer NICU stays. Introduction of SSEF protocol,
      led to a significant decrease in TANEC. There was no difference in weight and
      head circumference of infants in the two groups at 2 years corrected age.
      CONCLUSION: SSEF led to a significant reduction in the incidence of TANEC without
      impairing growth at 2 years corrected age.

PMID- 29843273
TI  - Post-discharge outcomes of failed car seat tolerance screens: A case-control and
      follow-up study.
AB  - BACKGROUND: Despite widespread implementation, limited data exists relating
      morbidity or adverse outcomes to Car Seat Tolerance Screen (CSTS) result in
      preterm and low birth weight (LBW) neonates. The objective of this study was to
      determine longer term post-discharge outcomes of infants who failed a CSTS.
      METHODS: We performed a case control study evaluating outcomes of infants born
      over one year who failed vs. passed an initial CSTS, utilizing both retrospective
      medical record review and parental survey data 2-3 years after discharge.
      Subjects were matched one case of failed CSTS to two controls who passed CSTS
      based on sex, gestational age, and BW. We performed bivariate analysis of
      clinical and demographic risk factors comparing those who passed vs. failed CSTS.
      RESULTS: We identified 19 subjects who failed and matched to 37 controls. Cases
      were significantly more likely to be diagnosed with obstructive sleep apnea (p =
      0.027), asthma (p = 0.016), and be treated with albuterol (p = 0.008). We did not
      find differences in frequency of urgent care visits or hospital admissions
      between the groups. Although more of the cases were noted to have developmental
      delays, the difference was not statistically significant. CONCLUSION: This is the
      first study to evaluate longer term post-discharge outcomes of subjects having
      undergone CSTS. Subjects who failed CSTS had significantly increased incidence of
      respiratory diagnoses such as OSA and asthma than matched controls by 2-3 years
      after discharge. Larger studies are necessary to further evaluate these findings,
      but this does provide data that CSTS may be useful in identifying at risk
      neonates.

PMID- 29843274
TI  - Decreasing NICU admissions of asymptomatic infants of women with pregestational
      diabetes mellitus improves breastfeeding initiation rates.
AB  - BACKGROUND: Asymptomatic infants born to women with pregestational diabetes
      mellitus (PGDM) are usually admitted to the well baby nursery (WBN) while those
      who are symptomatic or in need of specialized care are admitted to the neonatal
      intensive care unit (NICU). OBJECTIVE: To determine if changes in the NICU
      admission rate of asymptomatic infants born to women with PGDM during two
      different epochs affected breastfeeding (BF) initiation rates. DESIGN/METHODS:
      Retrospective cohort investigation of 386 women with PGDM and their infants who
      delivered in 2008-11 (epoch 1) and 457 who delivered in 2013-16 (epoch 2) at a
      single institution. RESULTS: NICU admissions: Comparison between epoch 1 and
      epoch 2 showed a decrease in the number of admissions from 243 (63%) to 175 (38%)
      *(chi square *p < 0.05). Respiratory distress (39 and 43%) and prematurity (28
      and 23%) as admission diagnoses remained unchanged. Admissions for prevention of
      hypoglycemia declined (32% to 21%)*. At discharge from the NICU, exclusive BF (12
      to 19%)* and any BF increased (41 to 55%)* while formula feeding (FF) decreased
      (59 to 45%)*. Admission to the NICU remained a strong predictor of BF initiation
      failure (a OR 0.6, 95% , CI 0.4-0.9, p 0.005).WBN admissions: Comparison between
      epoch 1 and epoch 2 showed an increase in the number of admissions from 143 (37%)
      to 282 (62%)*. The incidence of hypoglycemia (31% and 38%) and its correction
      with oral feedings (76% and 71%) remained unchanged. At discharge from the WBN,
      exclusive BF (15 to 27%)* and any BF (52 to 62%)* increased while FF decreased
      (48 to 38%)*. CONCLUSIONS: A decrease in the number of NICU admissions of
      asymptomatic infants born to women with PGDM is associated with improvements in
      BF initiation rates.

PMID- 29843275
TI  - eHealth solutions and nonurgent visits in emergency departments.

PMID- 29843276
TI  - Effects of robot-assisted training on upper limb functional recovery during the
      rehabilitation of poststroke patients.
AB  - BACKGROUND: The study aims to determine the effectiveness of robot-assisted
      training in the recovery of stroke-affected arms using an exoskeleton robot Armeo
      Spring. OBJECTIVE: To identify the effect of robot training on functional
      recovery of the arm. METHODS: A total of 34 stroke patients were divided into
      either an experimental group (EG; n= 17) or a control group (n= 17). EG was also
      trained to use the Armeo Spring during occupational therapy. Both groups were
      clinically assessed before and after treatment. Statistical comparison methods
      (i.e. one-tailed t-tests for differences between two independent means and the
      simplest test) were conducted to compare motor recovery using robot-assisted
      training or conventional therapy. RESULTS: Patients assigned to the EG showed a
      statistically significant improvement in upper extremity motor function when
      compared to the CG by FIM (P< 0.05) and ACER (P< 0.05). The calculated treatment
      effect in the EG and CG was meaningful for shoulder and elbow kinematic
      parameters. CONCLUSIONS: The findings show the benefits of robot therapy in two
      areas of functional recovery. Task-oriented robotic training in rehabilitation
      setting facilitates recovery not only of the motor function of the paretic arm
      but also of the cognitive abilities in stroke patients.

PMID- 29843277
TI  - Application of Zebris dynamometric platform and Arch Index in assessment of the
      longitudinal arch of the foot.
AB  - BACKGROUND: Assessment of the foot arch is an important element of posture
      examination. In clinical practice, different methods are used. Reliability and
      repeatability of the techniques raises many doubts. OBJECTIVE: Development and
      verification of our own, automated diagnostic algorithm for evaluation of the
      longitudinal arch of the foot with the use of the Zebris FDM-S dynamometric
      platform. METHODS: This paper presents selected footprints assessment methods and
      Zebris dynamometric platform to assess the longitudinal arch of the foot.
      RESULTS: The results were compared to standard plantography examination. The
      outcomes show high correlation of the investigated parameters methods used. The
      ambiguity of classification criteria of foot arch was observed. CONCLUSIONS:
      1/Examination confirmed strong linear correlation between the Arch Index results
      obtained during examinations on a stabilometric platform and plantography
      examination. 2/The proposed algorithm for AI evaluation using the Zebris FDM-S
      dynamometric platform enables simultaneous analysis of stabilometric and
      pedobarometric variables as well classifying the type of disorder arch
      longitudinal arch of the foot. 3/Qualitative analysis of the arch, based on
      plantography results and the Arch Index, shows inconsistency in results obtained
      with different methods. 4/The obtained results show further necessity to conduct
      more studies to develop methods of standardization of foot arch assessment.

PMID- 29843278
TI  - Investigation of the backflows and outlet boundary conditions for computations of
      the patient-specific aortic valve flows.
AB  - BACKGROUND: Simulation divergence due to the backflow through the outlet boundary
      is a common, but not fully addressed challenge in patient-specific simulations of
      the aortic valve flows. OBJECTIVE: The purpose of this study is to develop the
      outlet boundary conditions aiming to improve convergence of the patient-specific
      aortic valve computations and to control the backflow in the case of partial
      reversal of the flow through the outlet. METHODS: Haemodynamic analysis of the
      aortic valve flows governed by the Navier-Stokes equations is performed by using
      the finite volume method. The pressure distribution, obtained from the convergent
      computations driven by the outflow boundary condition, is approximated by the
      parabolic surface of revolution and prescribed on the outlet as the novel
      pressure boundary condition. RESULTS: Various types of outlet boundary conditions
      are investigated to evaluate their influence on the resulting backflows. The
      outflow boundary condition produces a smaller backflow than other investigated
      boundary conditions, but it causes the solution divergence. The proposed outlet
      boundary condition allows for continuing the solution and preserving the expected
      backflow. CONCLUSIONS: The proposed outlet boundary condition helps to achieve a
      convergent solution and to conserve the observed backflow by varying the
      convexity of the specified pressure surface.

PMID- 29843279
TI  - Shoulder torques resulting from luggage handling tasks in non-inertial frames.
AB  - BACKGROUND: This paper reports on the torques developed in the shoulder joint
      experienced by occupants of moving vehicles during manual handling tasks.
      Handling heavy weights can cause musculoskeletal injuries, especially if handling
      is done with arms extended or at high levels. OBJECTIVE: The aim of the study was
      to measure the longitudinal and lateral accelerations in a variety of passenger
      vehicles together with the postures of subjects lifting luggage onto storage
      shelves. This data enabled the application of inverse dynamics methods in a non
      inertial reference frame to calculate the shoulder joint torques. METHODS: The
      subjects lifted 3 pieces of luggage of masses of 5 kg, 10 kg and 14 kg onto
      shelving which were at heights of 1.2 m, 1.6 m and 1.8 m. The movement of
      subjects was measured using a 12 camera, 3-dimensional optical tracking system.
      The subjects stood on force plates to measure the ground reaction forces.
      RESULTS: Sixty-three trials were completed, although 9 trials were aborted
      because subjects felt unable to complete the task. It was found that the shoulder
      torques exceeded the levels recommend by the UK Health and Safety Executive for
      manual handling. A lift assistance device is suggested to reduce the shoulder
      torques required for luggage handling.

PMID- 29843280
TI  - The IR-thermal imaging method for evaluation of the status of myocardial coronary
      vessels under the condition of artificial blood circulation.
AB  - BACKGROUND: In this paper a method is proposed to evaluate the heart's coronary
      vessels' status based on the elimination of large coronary branches from IR
      thermal image. This method makes it possible to determine nutrient cardiac blood
      circulation by calculation of the rate of heat spreading in small coronary
      vessels in the myocardium at hypothermia and hyperthermia under the conditions of
      artificial blood circulation. OBJECTIVE: The objective of the paper includes a
      theoretical substantiation of the proposed method for evaluation of the heart's
      coronary vessels' status and an experimental investigation of the efficiency of
      the method. METHODS: In the experiment, the dynamics of temperature distribution
      in the myocardium were registered by using thermal imaging cameras Flir i7 and
      Thermo Cam E300. RESULTS: Processing of the myocardium's thermographic images and
      the results of heat spreading modeling make it possible to single out the
      temperature profiles of the visible myocardium zones and to establish the
      presence of coronary arteries in them. CONCLUSIONS: The method makes it possible
      to monitor the heart temperature at hypothermia and hyperthermia; additionally,
      it makes it possible to evaluate the efficiency of the coronary artery bypass
      graft surgery performed during open heart operation.

PMID- 29843281
TI  - A dynamic model of a device with a parallel-serial structure to support the human
      lower limb.
AB  - BACKGROUND: Support systems designed for human lower limbs are usually
      characterized by a serial kinematic structure taking into account only one lower
      limb. To overcome the mobility range limitations, a new structure of the
      exoskeleton is proposed in this paper. OBJECTIVE: The design process of the
      dynamic model for the support structure characterized by a parallel-serial
      mechanism is presented in the paper. The structure works as an exoskeleton and is
      designed to assist motion of the human lower limb in the process of
      rehabilitation. METHODS: The structure of the support model was divided into
      linear (executive system) and nonlinear (the mechanical skeleton of the system)
      parts. The model of the executive system was designed and its parameters were
      estimated in the course of tests on a laboratory stand, as well as identification
      procedures. The nonlinear model was expressed by mathematical equations. The
      characteristic coefficients in the equation were determined based on a 3d CAD
      model. RESULTS: To analyze the behavior of the mechanism, a simulation of dynamic
      responses was compared with experimental results for a real system consisting of
      a mechatronic device, actuator drivers, a controller, and programmed software.
      CONCLUSIONS: The proposed new structure enables an increase of the range of
      rotation angles and can be fitted to an individual person. The derived model is
      in the analytical form and can also be easily adopted to the different versions
      of the exoskeleton and used in the design of control systems.

PMID- 29843282
TI  - A pilot study on the influence of exercising on unstable training machine on
      balance control and trunk muscles activity.
AB  - BACKGROUND: The main position of the working population is becoming sitting.
      Immobile prolonged sedentary time may cause negative effects including reduced
      intervertebral discs nutrition. Main ways of mitigating them are regular position
      changes and exercising. OBJECTIVE: To evaluate influence of the short term
      training on unstable training machine on balance control and trunk muscles
      activity in patients with lower back pain. METHODS: Participants (n=16)
      experiencing lower back pain were trained on an unstable sculling machine
      "Rehabili". Their balance tested by (Biodex Balance System) and rectus abdominis,
      externus oblique, transverse abdominis, multifidus and erector spine muscles
      activity (measured by surface electromyography) while sitting and standing with
      usual and aligned body postures both before and after six weeks of training
      (three 15 minutes sessions per week) were compared in between. RESULTS: Balance
      control improved after the training program. Besides, more symmetrical activation
      of both sides rectus and transversus abdominis muscles, as well as increased
      transversus abdominis muscle activation of 19% (p< 0.05), were observed.
      CONCLUSIONS: Six weeks short sessions training on unstable training machine
      improved balance control and increased trunk muscles activity especially in
      aligned body posture when standing or sitting on unstable surface.

PMID- 29843283
TI  - Estimation of ground reaction forces and joint moments on the basis on plantar
      pressure insoles and wearable sensors for joint angle measurement.
AB  - BACKGROUND: Gait analysis is a useful tool medical staff use to support clinical
      decision making. There is still an urgent need to develop low-cost and
      unobtrusive mobile health monitoring systems. OBJECTIVE: The goal of this study
      was twofold. Firstly, a wearable sensor system composed of plantar pressure
      insoles and wearable sensors for joint angle measurement was developed. Secondly,
      the accuracy of the system in the measurement of ground reaction forces and joint
      moments was examined. METHODS: The measurements included joint angles and plantar
      pressure distribution. To validate the wearable sensor system and examine the
      effectiveness of the proposed method for gait analysis, an experimental study on
      ten volunteer subjects was conducted. The accuracy of measurement of ground
      reaction forces and joint moments was validated against the results obtained from
      a reference motion capture system. RESULTS: Ground reaction forces and joint
      moments measured by the wearable sensor system showed a root mean square error of
      1% for min. GRF and 27.3% for knee extension moment. The correlation coefficient
      was over 0.9, in comparison with the stationary motion capture system.
      CONCLUSIONS: The study suggests that the wearable sensor system could be
      recommended both for research and clinical applications outside a typical gait
      laboratory.

PMID- 29843284
TI  - Necessity of early-stage verticalization in patients with brain and spinal cord
      injuries: Preliminary study.
AB  - BACKGROUND: Integration of the verticalization robot, Erigo, with functional
      electric stimulation and passive leg movements in the postacute rehabilitation of
      neurological patients could reduce the risk of secondary complications and
      improve functional outcomes (i.e. orthostatic hypotension, postural control and
      walking ability). OBJECTIVE: The aim of this study was to estimate and quantify
      changes in the postacute stage, mainly related to heart rate and blood pressure
      in functional recovery, postural parameters, walking ability and psychoemotional
      reactions, during training using the verticalization robot Erigo. METHODS: Six
      patients [three suffering from a stroke (ST) and three with spinal cord injuries
      (SCI)] participated in 10 sessions of physical therapy with the verticalization
      robot during primary inpatient rehabilitation. Functional state changes were
      assessed using clinical tests before and after the treatment, and the loading
      tolerance during Erigo training was noted. RESULTS: In early rehabilitation,
      Erigo training was safe and effective at improving orthostatic tolerance, posture
      and positive emotional reactions in both the ST and SCI patients (P< 0.05). In
      addition, advanced technologies were more effective at boosting the orthostatic
      tolerance in SCI patients, while they were more effective at increasing the
      dynamic balance and walking ability in ST patients (P< 0.05).

PMID- 29843285
TI  - Experimental investigation of the determination for the safe operating regime of
      ultrasound tube-shaped waveguide wire for internal blood vessel debulking.
AB  - BACKGROUND: Majority of limb amputations are caused by circulatory disturbances
      such as vascular occlusions and strictures. Discovery of modern and more advanced
      ultrasonic interventional vascular debulking methodology would likely save limbs
      of CVD patients and their lives in an economical way. However, there is a lack of
      researches regarding the ultrasound's effect on physiological functions of human
      blood cells. The tube-shaped ultrasound waveguide wire with orifices at its
      operational end was offered as the alternative to some currently patented
      interventional thrombosis treatment solutions. OBJECTIVE: To establish the safe
      operating regime of the proposed device. METHODS: The temperature rise induced by
      the cavitation process and friction between the waveguide and surrounding fluids
      was measured and microscopic pictures of human blood were made. RESULTS: Blood
      insonation lasting 15 seconds, leads to blood clot formation. If insonation
      continues for 30 seconds some cells are totally destroyed. In addition, the safe
      operating regime was established. To avoid heating of the environment to the
      temperature harmful for the medium (blood) and surrounding tissues, is achieved
      when the system should be on for 40%, and of for 60% of the period of 1 second.
      CONCLUSIONS: The safe operating regime of the proposed device was established.

PMID- 29843286
TI  - Numerical simulation of transapical off-pump mitral valve repair with neochordae
      implantation.
AB  - BACKGROUND: Transapical off-pump mitral valve (MV) repair is a novel minimally
      invasive surgical technique, allowing to correct mitral regurgitation (MR) caused
      by chordae tendineae rupture. While numerical simulation of the MV structure has
      proven to be useful to evaluate the effects of the MV surgical repair techniques,
      no numerical simulation studies on the outcomes of transapical MV repair have
      been done up to now. OBJECTIVE: The purpose of this study is to evaluate the
      transapical MV repair using finite element modeling and to determine the effect
      of the neochordal length on the function of the prolapsing MV. METHODS: The
      reconstruction of the MV geometry based on the patient-specific data was
      performed. In order to simulate prolapse, chordae inserted into the middle
      segment of the posterior leaflet (P2) were ruptured. A total of four virtual
      transapical repairs using neochordae of different length were performed. The
      function of the MV before and after virtual repairs was simulated. RESULTS: The
      evaluation of the effect of the neochordal length on post-repair MV function
      showed that the length of the implanted neochordae has a significant impact on
      the correction of MR caused by chordae tendineae rupture. CONCLUSIONS: The
      presented results can improve the understanding of the effects of transapical MV
      repair.

PMID- 29843287
TI  - Quantitative assessment of upper extremities motor function in multiple
      sclerosis.
AB  - BACKGROUND: Upper extremity (UE) motor function deficits are commonly noted in
      multiple sclerosis (MS) patients and assessing it is challenging because of the
      lack of consensus regarding its definition. Instrumented biomechanical analysis
      of upper extremity movements can quantify coordination with different
      spatiotemporal measures and facilitate disability rating in MS patients.
      OBJECTIVE: To identify objective quantitative parameters for more accurate
      evaluation of UE disability and relate it to existing clinical scores. METHODS:
      Thirty-four MS patients and 24 healthy controls (CG) performed a finger-to-nose
      test as fast as possible and, in addition, clinical evaluation kinematic
      parameters of UE were measured by using inertial sensors. RESULTS: Generally, a
      higher disability score was associated with an increase of several temporal
      parameters, like slower task performance. The time taken to touch their nose was
      longer when the task was fulfilled with eyes closed. Time to peak angular
      velocity significantly changed in MS patients (EDSS > 5.0). The inter-joint
      coordination significantly decreases in MS patients (EDSS 3.0-5.5). Spatial
      parameters indicated that maximal ROM changes were in elbow flexion. CONCLUSIONS:
      Our findings have revealed that spatiotemporal parameters are related to the UE
      motor function and MS disability level. Moreover, they facilitate clinical rating
      by supporting clinical decisions with quantitative data.

PMID- 29843288
TI  - Low cost self-made pressure distribution sensors for ergonomic chair: Are they
      suitable for posture monitoring?
AB  - BACKGROUND: Long sitting causes many health problems for people. Healthy sitting
      monitoring systems, like real-time pressure distribution measuring, is in high
      demand and many methods of posture recognition were developed. Such systems are
      usually expensive and hardly available for the regular user. OBJECTIVE: The aim
      of study is to develop low cost but sensitive enough pressure sensors and posture
      monitoring system. METHODS: New self-made pressure sensors have been developed
      and tested, and prototype of pressure distribution measuring system was designed.
      RESULTS: Sensors measured at average noise amplitude of a = 56 mV (1.12%),
      average variation in sequential measurements of the same sensor s = 17 mV
      (0.34%). Signal variability between sensors averaged at 100 mV (2.0%). Weight to
      signal dependency graph was measured and hysteresis calculated. Results suggested
      the use of total sixteen sensors for posture monitoring system with accuracy of <
      1.5% after relaxation and repeatability of around 2%. CONCLUSION: Results
      demonstrate that hand-made sensor sensitivity and repeatability are acceptable
      for posture monitoring, and it is possible to build low cost pressure
      distribution measurement system with graphical visualization without expensive
      equipment or complicated software.

PMID- 29843289
TI  - The impact of body mass on spine alterations in pregnant women: A preliminary
      study.
AB  - BACKGROUND: Weight gain is the most significant change during pregnancy. The lack
      of consensus among scientists as far as significant spine alterations are
      concerned requires basic knowledge to be increased. OBJECTIVE: The aim of the
      paper is to determine changes in spine parameters occurring during pregnancy
      accompanying the increasing body gain. METHODS: Twelve pregnant women were
      included in this study. Winspine Pointer, a three-dimensional motion analysis
      system, was applied for the tests. The output measurements were: pelvic torsion,
      pelvic obliquity, pelvic/shoulder obliquity, thoracic kyphosis angle, lumbar
      lordosis angle, and sacral angle. The correlation between the BMI index and the
      spine parameters was investigated using Spearman's correlation coefficient.
      RESULTS: Differences between women in the 2nd and 3rd trimester of pregnancy were
      found for thoracic kyphosis angle and lumbar lordosis angle (P< 0.05). A
      statistically significant relationship was revealed between the BMI and the
      thoracic kyphosis in the 3rd trimester of pregnancy (R = 0.50, p= 0.005). With
      the increase of the BMI, the measured parameter also increased. CONCLUSIONS:
      Understanding the changes in spine parameters during pregnancy is important as
      far as prevention and treatment are concerned.

PMID- 29843290
TI  - Novel techniques for a wireless motion capture system for the monitoring and
      rehabilitation of disabled persons for application in smart buildings.
AB  - BACKGROUND: Due to the problem of aging societies, there is a need for smart
      buildings to monitor and support people with various disabilities, including
      rheumatoid arthritis. OBJECTIVE: The aim of this paper is to elaborate on novel
      techniques for wireless motion capture systems for the monitoring and
      rehabilitation of disabled people for application in smart buildings. METHODS:
      The proposed techniques are based on cross-verification of distance measurements
      between markers and transponders in an environment with highly variable
      parameters. To their verification, algorithms that enable comprehensive
      investigation of a system with different numbers of transponders and varying
      ambient parameters (temperature and noise) were developed. In the estimation of
      the real positions of markers, various linear and nonlinear filters were used.
      Several thousand tests were carried out for various system parameters and
      different marker locations. RESULTS: The results show that localization error may
      be reduced by as much as 90%. It was observed that repetition of measurements
      reduces localization error by as much as one order of magnitude. CONCLUSIONS: The
      proposed system, based on wireless techniques, offers a high commercial
      potential. However, it requires extensive cooperation between teams, including
      hardware and software design, system modelling, and architectural design.

PMID- 29843291
TI  - Modelling of silk-reinforced PDMS properties for soft tissue engineering
      applications.
AB  - BACKGROUND: Polydimethylsiloxane (PDMS) is widely used in biomedical research and
      technology, but its mechanical properties should be tuned according to the
      desired product specifications. Mixing ratio of base polymer to curing agent or
      additives enables its mechanical properties to be manipulated and fit to
      mechanical properties of biological tissues. OBJECTIVE: In this paper, we
      analysed the effect of mechanical load on silk-reinforced PDMS depending on silk
      concentration. METHODS: We prepared cylinder-type PDMS samples with different
      silk concentrations and performed cyclic uniaxial compression tests with a fixed
      magnitude of applied strain. Next, we analysed the mechanical charascteristics of
      PDMS using computational modelling. RESULTS: The stress-strain data within the
      large-strain region of different PDMS cylinders without silk and with 1%, 5% and
      10% silk concentrations was fitted to non-linear second order Mooney-Rivlin, and
      third-order Ogden models. The results show the equivalence of both models for
      investigated strain region of PDMS. On the other hand, PDMS cylinders with 10%
      silk concentration allowed the successful fitting of experimental data just for
      the second-order Mooney-Rivlin model, while all numerical probes to find an
      appropriate fitting parameters for third-order Ogden models were unsuccessful.
      CONCLUSIONS: The second-order Mooney-Rivlin model is preferable for analysing the
      properties of silk-reinforced PDMS over the entire measurement range.

PMID- 29843292
TI  - Editorial.

PMID- 29843293
TI  - Impact of Tumarkin attacks on complaints and work ability in Meniere's disease.
AB  - The purpose of the present study was to characterize the occurrence of Tumarkin
      attacks in patients with Meniere'sdisease (MD), and to study its association with
      reported complaints, severity of consequences, and also self-reported work
      ability. The study used a cross-sectional design. Data obtained from the Finnish
      Meniere Federation using an electronic survey was analyzed. 602 people with MD
      responded to the survey (62% response rate) with a mean age of 56.7 years and a
      mean duration of the disease 12.4 years. 49% of the respondents experienced
      Tumarkin attacks, which lasted for a few seconds to a few minutes. There were
      significant differences in complaints reported by MD patients with and without
      Tumarkin attacks. Respondents with Tumarkin attacks experienced various
      consequences, including tripping, falls, fear, anxiety, problems in dyadic life,
      and even transient loss of consciousness. Respondents with Tumarkin attacks had
      more frequently applied for pension than those not having Tumarkin attacks. On an
      average, respondents with Tumarkin attacks had less self-reported working ability
      when compared to those without Tumarkin attacks. The current study results
      suggest various differences in terms of complaints reported, severity of
      consequences, and the self-reported working ability in MD patients with and
      without Tumarkin attacks. Hearing healthcare professionals must examine Tumarkin
      attacks and their consequences in patients with MD during clinical examinations.
      In addition, the therapy should focus on alleviating the consequences and
      improving work ability.

PMID- 29843294
TI  - A literature review of anthropometric studies of school students for ergonomics
      purposes: Are accuracy, precision and reliability being considered?
AB  - BACKGROUND: Despite offering many benefits, direct manual anthropometric
      measurement method can be problematic due to their vulnerability to measurement
      errors. OBJECTIVE: The purpose of this literature review was to determine,
      whether or not the currently published anthropometric studies of school children,
      related to ergonomics, mentioned or evaluated the variables precision,
      reliability or accuracy in the direct manual measurement method. METHODS: Two
      bibliographic databases, and the bibliographic references of all the selected
      papers were used for finding relevant published papers in the fields considered
      in this study. RESULTS: Forty-six (46) studies met the criteria previously
      defined for this literature review. However, only ten (10) studies mentioned at
      least one of the analyzed variables, and none has evaluated all of them. Only
      reliability was assessed by three papers. Moreover, in what regards the factors
      that affect precision, reliability and accuracy, the reviewed papers presented
      large differences. This was particularly clear in the instruments used for the
      measurements, which were not consistent throughout the studies. Additionally, it
      was also clear that there was a lack of information regarding the evaluators'
      training and procedures for anthropometric data collection, which are assumed to
      be the most important issues that affect precision, reliability and accuracy.
      CONCLUSIONS: Based on the review of the literature, it was possible to conclude
      that the considered anthropometric studies had not focused their attention to the
      analysis of precision, reliability and accuracy of the manual measurement
      methods. Hence, and with the aim of avoiding measurement errors and misleading
      data, anthropometric studies should put more efforts and care on testing
      measurement error and defining the procedures used to collect anthropometric
      data.

PMID- 29843295
TI  - Road casualties in work-related and private contexts: occupational medical
      impact. Results from the ESPARR cohort.
AB  - BACKGROUND: Road accidents may impact victims' physical and/or mental health and
      socio-occupational life, notably including return to work. OBJECTIVES: To assess
      whether the occupational medical consequences sustained by subjects injured in
      road accidents occurring in a work-related context differ from those associated
      with private accidents. METHODS: 778 adults who were in work or occupational
      training at the time of their accident were included. Two groups were
      distinguished: 354 (45.5%) injured in road accidents occurring in a work-related
      context (commuting or on duty) and 424 (54.5%) injured in a private accident. The
      groups were compared on medical and occupational factors assessed on prospective
      follow-up at 6 months and 1 and 3 years. Multivariate analysis explored for
      factors associated at 6 months and 1 year with sick leave following the accident
      and duration of sick leave. RESULTS: There were no significant differences
      between groups for demographic data apart from a slightly higher injury severity
      in private accidents (32.5% of private accidents with MAIS3+(Maximum Abbreviated
      Injury Scale greater or equal to 3) vs. 23.7% for work-related accidents, p =
      0.007). Victims of work-related accidents were more often on sick leave (OR =
      1.8; 95% CI, 1.1-2.9). Although the length of sick leave is higher for work
      related accidents that for private accidents, multivariate analysis showed that
      the injury severity and the post-traumatic stress disorder (PTSD) are significant
      factors to explain the time to return to work. There were no significant
      differences according to occupational impact during follow-up, notably including
      sick-leave duration, number of victims returning to work within 3 years and
      number of victims out of work due to incapacity. CONCLUSIONS: In the ESPARR
      (follow-up study of a road-accident population in the Rhone administrative
      county: Etude de Suivi d'une Population d'Accidentes de la Route dans le Rhone)
      cohort, the fact that a road accident occurred in a work-related context did not
      affect the occupational consequences.

PMID- 29843296
TI  - Workplace relationships impact self-rated health: A survey of Swedish municipal
      health care employees.
AB  - BACKGROUND: The impact of positive social relationships on the health of
      municipal employees in the elder care sector in Sweden needs further examination.
      OBJECTIVE: To explore the association between health and relationships among
      elderly care employees using a salutogenic perspective. METHOD: Survey of all
      employees (n = 997) in special housing, home care and Disabled Support and
      Services in a Swedish municipality. The questionnaire, which had a salutogenic
      perspective, included information on self-rated health from the previously
      validated SHIS (Salutogenic Health Indicator Scale), psychosocial work
      environment and experiences, social climate, and health-promoting workplace
      relationships. RESULTS: The response rate was 69% . Results of a multivariable
      linear regression model showed four significant predictors of health: general
      work experiences, colleague belongingness and positive relationships with
      managers and care recipients. In another model, colleague belongingness was
      significantly related to satisfaction with care recipients, work, length of
      employment as well as general work experiences and relationships with managers.
      CONCLUSION: Strengthening of positive work relationships, not only between
      workmates but also with managers and care recipients, seems to be an essential
      area for employee health promotion. Colleague belongingness may be deepened by
      development of a positive work climate, including satisfactory work experiences,
      positive manager relationships and a stable work force.

PMID- 29843297
TI  - Enriched environment at work: Disassociated from stress and burnout.
AB  - BACKGROUND: Enriched environment at work (EEW), in terms of high mental demands
      at work, may be of great relevance for preventative efforts against cognitive
      decline and dementia as previous studies have shown. Yet, there is the concern
      that high EEW mental demands may accelerate stress and cause burnout. OBJECTIVE:
      The aim of our study was to investigate how EEW mental demands are related to
      stress and burnout. METHOD: A convenience sample of employees in the city area of
      Leipzig, Germany, was asked to fill out the Copenhagen Burnout Inventory and
      indicate for each EEW mental demand the level experienced, demandingness, and
      stressfulness. RESULTS: Multivariate linear regression and structural equation
      modelling suggested that only some EEW mental demands were perceived as stressful
      when the level of the respective EEW mental demand was high. Higher stressfulness
      was associated with burnout symptoms - however, high levels of EEW mental demands
      were not significantly associated with burnout (neither directly nor indirectly).
      CONCLUSIONS: Our findings implied that subjectively perceived stressfulness seems
      to be a more relevant aspect than the actual level of the demand itself. However,
      further studies are necessary to validate our findings.

PMID- 29843298
TI  - Preferential strengthening of VMO muscle during selected biomechanical
      rehabilitative exercises of automotive workers with patellofemoral pain syndrome.
AB  - BACKGROUND: Automotive workers are engaged in occupational activities like engine
      tune-ups, oil changes, tire rotation, wheel balancing, replacing filters etc.
      These activities involve prolonged sitting, awkward postures, squatting and
      kneeling, which are known risk factors to cause patellofemoral pain syndrome
      (PFPS). OBJECTIVE: This paper aims to investigate the effects of selected
      biomechanical rehabilitative exercises (BRE) on integrated electromyography
      (iEMG) activity of vastus medialis oblique (VMO) and vastus lateralis (VL)
      muscles so as to identify suitable ones to alleviate PFPS of automotive workers.
      METHODS: Eleven subjects, automotive workers having PFPS, performed four BRE: (1)
      short arc quad with neutral hip position (SAQN), (2) short arc quad with
      externally rotated hip position (SAQER), (3) medial tibial rotation (MTR), and
      (4) hip adduction (HA). RESULTS: Mean iEMG activity of VMO muscle is more than
      that of VL muscle during all BRE. However, one way ANOVA with repeated measures
      indicates that mean iEMG activity of VMO muscle is significantly higher than that
      of VL muscle during SAQER only. VMO/VL ratio is not significantly different
      across the four BRE. CONCLUSIONS: Results suggest a range of options for choosing
      appropriate BRE for treating automotive workers with PFPS. However, SAQER may
      directly be recommended for preferential strengthening of VMO muscle.

PMID- 29843299
TI  - Physician decision-making in the management of work related upper extremity
      injuries.
AB  - BACKGROUND: Physicians working in a tertiary care injured worker clinic are faced
      with clinical decision-making that must balance the needs of patients and society
      in managing complex clinical problems that are complicated by the work-workplace
      context. OBJECTIVE: The purpose of this study is to describe and characterize the
      decision-making process of upper extremity specialized surgeons when managing
      injured workers within a specialized worker's compensation clinic. METHOD:
      Surgeons were interviewed in a semi-structured manner. Following each interview,
      the surgeon was also observed in a clinic visit during a new patient assessment,
      allowing observation of the interactional patterns between surgeon and patient,
      and comparison of the process described in the interview to what actually
      occurred during clinic visits. RESULTS: The primary central theme emerging from
      the surgeon interviews and the clinical observation was the focus on the
      importance of comprehensive assessment to make the first critical decision: an
      accurate diagnosis. Two subthemes were also found. The first of these involved
      the decision whether to proceed to management strategies or to continue with
      further investigation if the correct diagnosis is uncertain. Once the central
      theme of diagnosis was achieved, a second subtheme was highlighted; selecting
      appropriate management options, given the complexities of managing the injured
      worker, the workplace, and the compensation board. CONCLUSIONS: This study
      illustrates that upper extremity surgeons rely on their training and experience
      with upper extremity conditions to follow a sequential but iterative decision
      making process to provide a more definitive diagnosis and treatment plan for
      workers with injuries that are often complex. The surgeons are challenged by the
      context which takes them out of their familiar zone of typical clinical practice
      to deal with the interactions between the injury, worker, work, workplace and
      insurer.

PMID- 29843300
TI  - Critical factors for the return-to-work process among people with affective
      disorders: Voices from two vocational approaches.
AB  - BACKGROUND: Depression is among the major causes of disability with a negative
      impact on both daily life and work performance. Whilst depression is the primary
      cause of sick-leave and unemployment in today's workplace there is a lack of
      knowledge of the needs of individuals with depression regarding their return-to
      work (RTW) process. OBJECTIVE: To explore which factors are of critical
      importance for people suffering from depression and who also are unemployed in
      their RTW-process and to explore the impact of two vocational approaches on the
      service users' experiences. The study included participants in two vocational
      rehabilitation approaches; Individual Enabling and Support (IES) and Traditional
      Vocational Rehabilitation (TVR). METHOD: Qualitative methods were applied to
      explore critical factors in the RTW-process. Individuals with affective disorders
      including depression and bipolar disorder were included.RESULTSThree themes
      emerged as critical factors; Experiencing hope and power, professionals' positive
      attitudes, beliefs and behaviours, and employing a holistic perspective and
      integrating health and vocational service.CONCLUSIONThis study has demonstrated
      critical factors for the return-to-work process as experienced by persons with
      depression. To experience hope and power, to meet professionals that believe "you
      can work", who use a person-centred and holistic service approach, are such
      factors necessary for gaining a real job. In particular, professionals in TVR
      need to embrace this understanding since their services were not experienced as
      including these elements.

PMID- 29843302
TI  - From the Editor.

PMID- 29843301
TI  - Development of new hard hat dimensions using user-centered design approach among
      oil palm harvesters.
AB  - BACKGROUND: Hard hats are among the personal protective equipment (PPE) used in
      many industries to reduce the impact of any falling object on the skull and also
      to prevent head and brain injuries. However, the practice of wearing a safety
      helmet during working hours is still low. This is due to the physical discomfort
      perceived by safety helmet users. OBJECTIVE: Given the unpopularity of the
      current hard hat, the general perception of workers concerning its use and its
      measurements are the determining factors in the development of a new hard hat.
      METHOD: A cross-sectional study was conducted in which 132 male oil palm
      harvesters between 19 and 60 years of age were selected from among the employees
      of the same oil palm harvesting company. A set of questionnaires was developed to
      collect their socio-demographic information as well as their perceptions of
      comfort and the prevalence of head injury. In addition, a set of measuring
      instruments, including Martin's anthropometry set, was used for head measurement
      and data collection in respect of the current hard hat. In this research, six
      respondents were randomly selected to attend an interview session for qualitative
      assessment.RESULTSBased on the questionnaires, the unpopularity in the use of the
      hard hat was largely influenced by factors related to poor design, in general,
      and, specifically, poor ventilation (64%), load (67% ), and physical discomfort
      (42% ). The measurements of the anthropometric parameters and the dimensions of
      the hard hat also showed a significant mismatch. CONCLUSION: The unpopularity of
      the current hard hat among oil palm harvesters stemmed from the discomfort from
      wearing, which showed that the development of a new hard hat could lead to better
      usage and the greater likelihood of wearing a hard hat throughout the working
      day.

PMID- 29843304
TI  - Treatment of Depression in India.

PMID- 29843303
TI  - Helicobacter pylori.

PMID- 29843305
TI  - Testicular histology and gonadotropin levels in infertile men with non
      obstructive oligo-/azoospermia.
AB  - The common histological abnormalities on testicular histology in 79 infertile
      virile men were hypospermatogenesis (35%), severe testicular atrophy (29%) and
      maturation arrest (19%). Sperm counts showed no correlation with testicular size,
      gonadotropin levels and histological classification. There was elevation of mean
      follicle stimulating hormone levels in males with maturation arrest (5.8+/-3.8
      lUlL) and Sertoli-cell only syndrome (21.7+/-3.4 lUlL). Patients with severe
      testicular atrophy had elevated luteinizing hormone (15.1+/-11.8 lUlL) as well as
      follicle stimulating hormone (49.8+/-11.4 lUlL) levels. Patients with
      hypospermatogenesis and focal atrophy had normal luteinizing hormone and follicle
      stimulating hormone levels and all of them had normal testosterone and prolactin
      levels. Treatment with gonadotropins or clomiphene citrate was ineffective.

PMID- 29843307
TI  - The infant's cry in health and disease.

PMID- 29843306
TI  - Interleukin-2 and lymphokine activated killer cell phenomenon: Biological
      considerations and clinical applications.

PMID- 29843308
TI  - Parkinson's disease and deprenyl.

PMID- 29843309
TI  - Vitamins, minerals and intelligence of school children.

PMID- 29843310
TI  - The Primitives knew best: Squatting during labour.

PMID- 29843311
TI  - Dilated cardiomyopathy.

PMID- 29843312
TI  - Splints in emergency care.

PMID- 29843313
TI  - The management of traumatic paraplegia.

PMID- 29843314
TI  - Research data management in health-related studies.

PMID- 29843315
TI  - Sher-i-Kashmir Institute of Medical Sciences, Srinagar.

PMID- 29843316
TI  - Letter from North America.

PMID- 29843317
TI  - Letter from London.

PMID- 29843318
TI  - Letter from Moscow.

PMID- 29843319
TI  - Family Planning and Kerala.

PMID- 29843320
TI  - Prevention of blindness in India.

PMID- 29843321
TI  - The Sun and the Skin.

PMID- 29843322
TI  - Anti-thrombotic Therapy in Acute Coronary Occlusion.

PMID- 29843323
TI  - A comparison of extra-amniotic physiological saline and ethacridine dye
      instillation for induction of mid-trimester abortion.
AB  - In a prospective, randomized study of 209 patients, we induced mid-trimester
      abortion by instilling either normal saline (105cases) or ethacridine dye
      (Emcredil(r)) (104cases) extra-amniotically. The mean induction-abortion interval
      for saline was 18 hours 25 minutes and for emcredil20 hours 12minutes. For a 'cut
      off' time of30 hours there were 9 failures with normal saline and 7 failures with
      ethacridine but all women eventually aborted without surgical intervention. In
      the saline group the induction-abortion interval was longer in the more advanced
      than in the less advanced pregnancies. No difference was observed in
      bacteriological studies from samples collected before and 24 hours after
      instillation of the solution. We conclude that normal saline is a cheap, easily
      available and safe abortifacient.

PMID- 29843324
TI  - Ultrasound guided percutaneous intervention in the complicated renal transplant.
AB  - We successfully performed 19 ultrasound guided percutaneous interventional
      procedures on 10 renal transplant recipients with urological complications. Seven
      of the procedures were diagnostic (antegrade pyelograms) and 12 therapeutic
      (aspiration of pelvic fluid collections 9, and percutaneous nephrostomies 3). All
      procedures were without major complications. The diagnostic procedures provided
      information which' contributed to better patient management. The therapeutic
      procedures improved the renal functions of patients and stabilized them for
      surgical management when necessary. We conclude that ultrasound guided
      percutaneous interventional procedures are safe and they may be helpful in the
      management of urological complications in renal transplant recipients.

PMID- 29843325
TI  - Nosocomial complicated urinary tract infections: A rural based referral hospital
      study.
AB  - A three-year retrospective study of urinary tract infection in 891 patients was
      conducted at a rural based hospital in coastal Karnataka, South India. Eighty
      eight per cent of the patients had complicated urinary tract infections with
      predominantly nosocomial organisms such as Klebsiella as opposed to the normally
      more common uncomplicated infection with E. coli. The reasons for this seem to be
      the delay in referral, resulting in late correction of the underlying structural
      causes of the infections. In our series of patients, the association of prolonged
      indwelling catheter drainage with complicated urinary tract infection suggests
      that non-urologists should adopt alternative measures such as clean intermittent
      catheterization, and reduce the period of indwelling catheters to the shortest
      time possible. More judicious selection and timing of antibiotic therapy might
      prevent the development of resistant organisms.

PMID- 29843326
TI  - Autopsy report of a case of AIDS.
AB  - We describe the autopsy findings in a prostitute, aged 38, who had recurrent
      fever, lymphadenopathy, anorexia and progressiveweight loss. Serology confirmed
      the presence of HTLV III antibodies. There was evidence of immunodeficiency with
      widespread opportunistic infections by candida, cryptococcus, mycobacteria and
      the cytomegalovirus.

PMID- 29843327
TI  - Antigen detection for diagnosing pneumococcal pneumonia.

PMID- 29843328
TI  - Breast cancer screening in Edinburgh.

PMID- 29843329
TI  - The topoisomerase 'poisons'.

PMID- 29843330
TI  - Subacute mountain sickness.

PMID- 29843331
TI  - A man with diarrhoea, weight loss and a rectal mass.

PMID- 29843332
TI  - Liver biopsy.

PMID- 29843333
TI  - The optimal use of health resources by a functional classification of diseases.

PMID- 29843334
TI  - Eminent Indians in medicine.

PMID- 29843335
TI  - Letter from London.

PMID- 29843336
TI  - Letter from Moscow.

PMID- 29843337
TI  - Letter from North America.

PMID- 29843338
TI  - Large volume paracentesis.

PMID- 29843339
TI  - Mahatma Gandhi Institute of Medical Sciences and Kasturba Hospital, Sevagram,
      Wardha.

PMID- 29843340
TI  - Breastfeeding in the 1990s.

PMID- 29843341
TI  - Cardiac Surgery in Infancy.

PMID- 29843342
TI  - Private doctors and public health: The case of leprosy in Bombay, India.
AB  - People in India tend to prefer private medical care to the existing government
      health services. Nevertheless, the large private health care sector has hitherto
      been virtually alienated from activities of public health importance including
      priority disease control programmes. This study of 106private general
      practitioners (GPs), practising in the slums of Bombay, shows a gross lack of
      knowledge and awareness about leprosy and also about the National Leprosy Control
      Programme. Active involvementof GPs in the National Programme should facilitate
      both the integration and better implementation of leprosy control activities. The
      study also highlights some areas for intervention at both the primary and
      secondary health care levels and the need for a strategy to train and make
      private doctors help control diseases which are of major public health concern.

PMID- 29843343
TI  - Ultrasonographic evaluation of carcinoma of the gall bladder.
AB  - Out of 6018 patients who were evaluated ultrasonographically for gastrointestinal
      problems over a four-and-a-half year period, 201 patients with a mean age of 53
      years were diagnosed to have carcinoma of the gall bladder (3.3%). In 191 of
      these the diagnosis was confirmed by laparotomy and histopathological examination
      and in 3 other patients ultrasound guided fine needle aspiration cytology yielded
      malignant cells. In the remaining 7 patients the diagnosis was not confirmed by
      tissue examination-3 had metastases and 4 refused further investigation. Two sets
      of features were detected on ultrasonography: type I-a mass occupying the gall
      bladder fossa and obliterating the lumen (144 patients), and type 11-a polypoid
      lesion projecting into the gall bladder lumen (57 patients). Gallstones were
      present in 157 patients (78%) but more often in patients with the type I
      features. Associated ultrasonographic features such as liver and lymph node
      involvement, dilatation of intrahepatic bile ducts and ascites were also
      assessed. We conclude that abdominal realtime ultrasonography is a reliable
      method for diagnosing carcinoma of the gall bladder.

PMID- 29843344
TI  - Evaluation of the single tube osmotic fragility test in detection of beta
      thalassaemia trait.
AB  - NESTROFT (the Naked Eye Single Tube Red Cell Osmotic Fragility Test) is a
      simpleand inexpensivemethod for detecting the beta-thalassaemiatrait in the
      general population. Its results, however, depend on visual interpretation. We
      assessed interobserver variability in the recording of results by three
      individuals on 380 samples of blood collected intravenously. We also tested 745
      samples by finger prick using a drop of blood or a uniform (20 MUl) volume and
      found that when a uniform volume was tested the proportion of false positive
      results was7% (28/380)as compared to 22% (79/365) when a drop was used. We found
      that although there-was little variation in recording negative results, there was
      more variation in recording positive or doubtful results.We conclude that when
      the NESTROFT in field tests is positive or doubtful, then the blood should be
      further tested in a laboratory for Hb A2 and a uniform volume of blood rather
      than an arbitrary drop should be used in the test. NESTROFT is suitable for large
      scale preliminary screening for the beta-thalassaemiatrait in India.

PMID- 29843345
TI  - Occupational medicine.

PMID- 29843346
TI  - Tuberculosis-The search for optimal treatment.

PMID- 29843347
TI  - HTLV-l related diseases: New risks from blood transfusion.

PMID- 29843348
TI  - Chemotherapy for abdominal tuberculosis.

PMID- 29843349
TI  - Hypoglycaemia in childhood diarrhoea.

PMID- 29843350
TI  - Viral Hepatitis: Agents and the Disease.

PMID- 29843351
TI  - Family Planning and Kerala.
AB  - The population control policies of the state of Kerala are reviewed and analysed.
      The historical factors which laid the foundation for present-day achievements in
      Kerala were the enlightened attitudes of the rulers of Travancore and Cochin, and
      the influence of Christianity on education. The reasons for the indifferent
      progress in family planning in the rest of India are discussed, and some
      suggestions are made as to how the Kerala experience could be implemented in the
      other states. The most important factor in a successful population control policy
      is the order in which changes should occur; improved health services resulting in
      a fall in infant and child mortality rates; increased female education;
      redistributive economic policies; and easily accessible and freely available
      family planning services.

PMID- 29843352
TI  - Letter from London.

PMID- 29843353
TI  - Letter from Moscow.

PMID- 29843355
TI  - Trade in human organs: Should it be allowed?

PMID- 29843354
TI  - Letter from North America.

PMID- 29843356
TI  - Doctor or deity?

PMID- 29843357
TI  - One-Stop Dispensing: Hospital Costs and Patient Perspectives on Self-Management
      of Medication.
AB  - (1) Objective: To assess hospital medication costs and staff time between One
      Stop Dispensing (OSD) and the Traditional Medication System (TMS), and to
      evaluate patient perspectives on OSD. (2) Methods: The study was conducted at
      Hvidovre Hospital, University of Copenhagen, Denmark in an elective gastric
      surgery and acute orthopedic surgery department. This study consists of three sub
      studies including adult patients able to self-manage medication. In Sub-study 1,
      staff time used to dispense and administer medication in TMS was assessed.
      Medication cost and OSD staff time were collected in Sub-study 2, while patient
      perspectives were assessed in Sub-study 3. Medication costs with two days of
      discharge medication were compared between measured OSD cost and simulated TMS
      cost for the same patients. Measured staff time in OSD was compared to simulated
      staff time in TMS for the same patients. Patient satisfaction related to OSD was
      evaluated by a questionnaire based on a five-point Likert scale ('very poor' (1)
      to 'very good' (5)). (3) Results: In total, 78 elective and 70 acute OSD patients
      were included. Overall, there was no significant difference between OSD and TMS
      in medication cost per patient ($2.03 [95% CI -0.57-4.63]) (p = 0.131). Compared
      with TMS, OSD significantly reduced staff time by an average of 12 min (p <=
      0.001) per patient per hospitalization. The patients' satisfaction for OSD was
      high with an average score of 4.5 +/- 0.7. (4) Conclusion: There were no
      differences in medication costs, but staff time was significantly lower in OSD
      and patients were overall satisfied with OSD.

PMID- 29843358
TI  - Angucycline Glycosides from Mangrove-Derived Streptomycesdiastaticus subsp. SCSIO
      GJ056.
AB  - Nine new angucycline glycosides designated urdamycins N1-N9 (1-9), together with
      two known congener urdamycins A (10) and B (11), were obtained from a mangrove
      derived Streptomycesdiastaticus subsp. SCSIO GJ056. The structures of new
      compounds were elucidated on the basis of extensive spectroscopic data analysis.
      The absolute configurations of 6-9 were assigned by electronic circular dichroism
      calculation method. Urdamycins N6 (6) and N9 (9) represent the first naturally
      occurring (5R, 6R)-angucycline glycosides, which are diastereomers of urdamycins
      N7 (7) and N8 (8), respectively.

PMID- 29843359
TI  - Development of an Experimental Model for Analyzing Drug Resistance in Colorectal
      Cancer.
AB  - Colorectal cancer (CRC) is one of the most common cancers, for which combination
      treatment of chemotherapy is employed. However, most patients develop drug
      resistance during the course of treatment. To clarify the mechanisms of drug
      resistance, various research models have been developed. Recently, we established
      a human CRC patients-derived three-dimensional (3D) culture system using an air
      liquid interface organoid method. It contained numerous cancer stem cells and
      showed resistance to 5-fluorouracil and Irinotecan. In this review, we introduce
      conventional and our established models for studying drug resistance in CRC.

PMID- 29843360
TI  - Social Medicine: Twitter in Healthcare.
AB  - Social media enables the public sharing of information. With the recent emphasis
      on transparency and the open sharing of information between doctors and patients,
      the intersection of social media and healthcare is of particular interest.
      Twitter is currently the most popular form of social media used for healthcare
      communication; here, we examine the use of Twitter in medicine and specifically
      explore in what capacity using Twitter to share information on treatments and
      research has the potential to improve care. The sharing of information on Twitter
      can create a communicative and collaborative atmosphere for patients, physicians,
      and researchers and even improve quality of care. However, risks involved with
      using Twitter for healthcare discourse include high rates of misinformation,
      difficulties in verifying the credibility of sources, overwhelmingly high volumes
      of information available on Twitter, concerns about professionalism, and the
      opportunity cost of using physician time. Ultimately, the use of Twitter in
      healthcare can allow patients, healthcare professionals, and researchers to be
      more informed, but specific guidelines for appropriate use are necessary.

PMID- 29843361
TI  - The Growth Proliferation, Apoptotic Prevention, and Differentiation Induction of
      the Gelatin Hydrolysates from Three Sources to Human Fetal Osteoblasts (hFOB 1.19
      Cells).
AB  - Gelatins from the skin of bovine, porcine, and tilapia were hydrolyzed to three
      degrees of hydrolysis (DH) by alcalase, neutrase, and papain, respectively. These
      hydrolysates at 0.02-0.1 g/L promoted the growth of human fetal osteoblasts by
      101.4-135.7%, while higher DH or using papain and tilapia gelatins resulted in
      higher proliferation. The hydrolysates from porcine and tilapia gelatins at 0.05
      g/L prevented induced apoptosis (decreasing total apoptotic proportions from
      28.4% or 35.2% to 10.3-17.5% or 16.0-23.6%), and had differentiation induction
      (increasing alkaline phosphatase activity by 126.9-246.7% in early
      differentiation stage, or enhancing osteocalcin production by 4.1-22.5% in later
      differentiation stage). These hydrolysates had a similar amino acid profile;
      however, tilapia gelatin hydrolysates by papain with DH 15.4% mostly displayed
      higher activity than others. Tilapia gelatin hydrolysate could up-regulate beta
      catenin, Wnt 3a, Wnt 10b, cyclin D1, and c-Myc expression at mRNA levels by 1.11
      3.60 folds, but down-regulate GSK 3beta expression by 0.98 fold. Of note, beta
      catenin in total cellular and nuclear protein was up-regulated by 1.14-1.16 folds
      but unchanged in cytoplasmic protein, Wnt 10b, cyclin D1, and c-Myc expression
      were up-regulated by 1.27-1.95 folds, whilst GSK 3beta expression was down
      regulated by 0.87 fold. Activation of Wnt/beta-catenin pathway is suggested to
      mediate cell proliferation and differentiation.

PMID- 29843362
TI  - Phenytoin Cream for the Treatment for Neuropathic Pain: Case Series.
AB  - BACKGROUND: Neuropathic pain can be disabling, and is often difficult to treat.
      Within a year, over half of all patients stop taking their prescribed neuropathic
      pain medication, which is most probably due to side effects or disappointing
      analgesic results. Therefore, new therapies are needed to alleviate neuropathic
      pain. As such, topical analgesics could be a new inroad in the treatment of
      neuropathic pain. In 2014, we developed a new topical formulation containing
      either phenytoin or sodium phenytoin. After optimization of the formulation, we
      were able to reach a 10% concentration and combine phenytoin with other co
      analgesics in the same base cream. OBJECTIVE: To describe a series of 70
      neuropathic pain patients who were treated with phenytoin cream. MATERIAL AND
      METHODS: Cases treated with phenytoin 5% or 10% creams were gathered. The mean
      onset of pain relief, the duration of effect, and reduction in pain intensity
      measured on the 11-point numerical rating scale (NRS) were all studied. A single
      blind response test with phenytoin 10% and placebo creams was conducted on 12
      patients in order to select responders prior to prescribing the active cream.
      Plasma phenytoin concentrations were measured in 16 patients. RESULTS: Nine
      patients applied phenytoin 5% cream, and 61 patients used phenytoin 10% cream.
      After grouping the effects of all of the patients, the mean onset of pain relief
      was 16.3 min (SD: 14.8), the mean duration of analgesia was 8.1 h (SD: 9.1), and
      the mean pain reduction on the NRS was 61.2% (SD: 25.0). The mean pain reduction
      on the NRS while using phenytoin cream was statistically significant compared
      with the baseline, with a reduction of 4.5 (CI: 4.0 to 5.0, p < 0.01). The 12
      patients on whom a single-blind response test was performed experienced a
      statistically significant reduction in pain in the area where the phenytoin 10%
      cream was applied in comparison to the area where the placebo cream was applied
      (p < 0.01). Thirty minutes after the test application, the mean pain reduction on
      the NRS in the areas where the phenytoin 10% cream and the placebo cream were
      applied was 3.3 (CI: 2.3 to 4.4, p < 0.01) and 1.1 (CI: 0.4 to 1.9, p < 0.05),
      respectively. In all 16 patients, the phenytoin plasma levels were below the
      limit of detection. So far, no systemic side effects were reported. Two patients
      only reported local side effects: a transient burning aggravation and skin rash.
      CONCLUSION: In this case series, the phenytoin cream had reduced neuropathic pain
      considerably, with a fast onset of analgesic effect.

PMID- 29843363
TI  - Effect of CNT/PDMS Nanocomposites on the Dynamics of Pioneer Bacterial
      Communities in the Natural Biofilms of Seawater.
AB  - In this study, the antifouling (AF) performance of different carbon nanotubes
      (CNTs)-modified polydimethylsiloxane (PDMS) nanocomposites (PCs) was examined
      directly in the natural seawater, and further analyzed using the Multidimensional
      Scale Analyses (MDS) method. The early-adherent bacterial communities in the
      natural biofilms adhering to different PC surfaces were investigated using the
      single-stranded conformation polymorphism (SSCP) technique. The PCs demonstrated
      differences and reinforced AF properties in the field, and they were prone to
      clustering according to the discrepancies within different CNT fillers.
      Furthermore, most PC surfaces only demonstrated weak modulating effects on the
      biological colonization and successional process of the early bacterial
      communities in natural biofilms, indicating that the presence of the early
      colonized prokaryotic microbes would be one of the primary causes of colonization
      and deterioration of the PCs. C6 coating seems to be promising for marine AF
      applications, since it has a strong perturbation effect on pioneer prokaryotic
      colonization.

PMID- 29843364
TI  - Enhancing Thermoelectric Properties through Control of Nickel Interstitials and
      Phase Separation in Heusler/Half-Heusler TiNi1.1Sn Composites.
AB  - Thermoelectric devices, which allow direct conversion of heat into electrical
      energy, require materials with improved figures of merit ( z T ) in order to
      ensure widespread adoption. Several techniques have been proposed to increase the
      z T of known thermoelectric materials through the reduction of thermal
      conductivity, including heavy atom substitution, grain size reduction and
      inclusion of a semicoherent second phase. The goal in these approaches is to
      reduce thermal conductivity through phonon scattering without modifying the
      electronic properties. In this work, we demonstrate that Ni interstitials in the
      half-Heusler thermoelectric TiNiSn can be created and controlled in order to
      improve physical properties. Ni interstitials in TiNi 1.1 Sn are not
      thermodynamically stable and, instead, are kinetically trapped using appropriate
      heat treatments. The Ni interstitials, which act as point defect phonon
      scattering centers and modify the electronic states near the Fermi level, result
      in reduced thermal conductivity and enhance the Seebeck coefficient. The best
      materials tested here, created from controlled heat treatments of TiNi 1.1 Sn
      samples, display z T = 0.26 at 300 K, the largest value reported for compounds in
      the Ti-Ni-Sn family.

PMID- 29843365
TI  - A Simplified Hollow-Core Photonic Crystal Fiber SERS Probe with a Fully Filled
      Photoreduction Silver Nanoprism.
AB  - In this paper, a simplified hollow-core photonic crystal fiber surface-enhanced
      Raman scattering (SERS) probe is presented. Silver nanoprisms are grown with a
      photoreduction method and account for the SERS, which have better electromagnetic
      enhancement than spherical silver nanoparticles at 785 nm. Due to the
      antiresonant reflecting guidance mechanism, the excited laser and SERS signal are
      effectively guided in such a fully filled hollow-core photonic crystal fiber SERS
      probe and complicated selective filling with target sample is avoided. Rhodamine
      6G molecules are used as probe molecules and the simplified hollow-core photonic
      crystal fiber SERS probe is test. Detection of low concentration Rhodamine 6G
      down to 10-8 M is achieved with a short integration time of 300 ms.

PMID- 29843366
TI  - DNA Damage-Response Pathway Heterogeneity of Human Lung Cancer A549 and H1299
      Cells Determines Sensitivity to 8-Chloro-Adenosine.
AB  - Human lung cancer H1299 (p53-null) cells often display enhanced susceptibility to
      chemotherapeutics comparing to A549 (p53-wt) cells. However, little is known
      regarding to the association of DNA damage-response (DDR) pathway heterogeneity
      with drug sensitivity in these two cells. We investigated the DDR pathway
      differences between A549 and H1299 cells exposed to 8-chloro-adenosine (8-Cl
      Ado), a potential anticancer drug that can induce DNA double-strand breaks
      (DSBs), and found that the hypersensitivity of H1299 cells to 8-Cl-Ado is
      associated with its DSB overaccumulation. The major causes of excessive DSBs in
      H1299 cells are as follows: First, defect of p53-p21 signal and phosphorylation
      of SMC1 increase S phase cells, where replication of DNA containing single-strand
      DNA break (SSB) produces more DSBs in H1299 cells. Second, p53 defect and no
      available induction of DNA repair protein p53R2 impair DNA repair activity in
      H1299 cells more severely than A549 cells. Third, cleavage of PARP-1 inhibits
      topoisomerase I and/or topoisomerase I-like activity of PARP-1, aggravates DNA
      DSBs and DNA repair mechanism impairment in H1299 cells. Together, DDR pathway
      heterogeneity of cancer cells is linked to cancer susceptibility to DNA damage
      based chemotherapeutics, which may provide aid in design of chemotherapy strategy
      to improve treatment outcomes.

PMID- 29843367
TI  - Prognostic Value of RNASEH2A-, CDK1-, and CD151-Related Pathway Gene Profiling
      for Kidney Cancers.
AB  - The nucleotide degrading enzyme gene RNASEH2A (ribonuclease H2 subunit A) has
      been found to be overexpressed in cancers. Our aim was to understand the role of
      RNASEH2A in cancer prognostication and to establish a scoring system based on the
      expressions of genes interacting with RNASEH2A. We screened the nucleotide
      degrading enzyme gene expression in RNAseq data of 14 cancer types derived from
      The Cancer Genome Atlas (TCGA) and found that RNASEH2A overexpression was
      associated with poor patient survival only in renal cell carcinomas (RCCs).
      Further cluster analyses of samples with poor outcomes revealed that cluster of
      differentiation 151 (CD151) upregulation correlated with low cyclin dependent
      kinase 1 (CDK1) and high RNASEH2A expression. The combination of low CD151
      expression and high RNASEH2A expression resulted in impaired proliferation in
      four kidney cancer cell lines, suggesting potential synthetic dosage lethality
      (SDL) interactions between the two genes. A prognostication scoring system was
      established based on the expression levels of RNASEH2A-, CDK1-, and CD151-related
      genes, which could effectively predict the overall survival in a TCGA clear cell
      RCC cohort (n = 533, 995.3 versus 2242.2 days, p < 0.0001), in another clear cell
      renal cell carcinoma (ccRCC) cohort E-GEOD-22541 (n = 44, 390.0 versus 1889.2
      days, p = 0.0007), and in a TCGA papillary RCC (pRCC) cohort (n = 287, 741.6
      versus 1623.7 days, p < 0.0001). Our results provide a clinically applicable
      prognostication scoring system for renal cancers.

PMID- 29843368
TI  - Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides.
AB  - Short oligonucleotides with cyclopalladated benzylamine moieties at their 5'
      termini have been prepared to test the possibility of conferring palladacyclic
      anticancer agents sequence-selectivity by conjugation with a guiding
      oligonucleotide. Hybridization of these oligonucleotides with natural
      counterparts was studied by UV and CD (circular dichroism) melting experiments in
      the absence and presence of a competing ligand (2-mercaptoethanol).
      Cyclopalladated benzylamine proved to be strongly stabilizing relative to
      unmetalated benzylamine and modestly stabilizing relative to an extra A*T base
      pair. The stabilization was largely abolished in the presence of 2
      mercaptoethanol, suggesting direct coordination of Pd(II) to a nucleobase of the
      complementary strand. In all cases, fidelity of Watson-Crick base pairing between
      the two strands was retained. Hybridization of the cyclopalladated
      oligonucleotides was characterized by relatively large negative enthalpy and
      entropy, consistent with stabilizing Pd(II) coordination partially offset by the
      entropic penalty of imposing conformational constraints on the flexible
      diethylene glycol linker between the oligonucleotide and the palladacyclic
      moiety.

PMID- 29843369
TI  - Health Monitoring of Bolted Spherical Joint Connection Based on Active Sensing
      Technique Using Piezoceramic Transducers.
AB  - Bolted spherical joints are widely used to form space steel structures. The
      stiffness and load capacity of the structures are affected by the looseness of
      bolted spherical joint connections in the structures. The looseness of the
      connections, which can be caused by fabrication error, low modeling accuracy, and
      "false twist" in the installation process, may negatively impact the load
      capacity of the structure and even lead to severe accidents. Furthermore, it is
      difficult to detect bolted spherical joint connection looseness from the outside
      since the bolts connect spheres with rods together from the inside. Active
      sensing methods are proposed in this paper to monitor the tightness status of the
      bolted spherical connection using piezoceramic transducers. A triangle-on
      triangle offset grid composed of bolted spherical joints and steel tube bars was
      fabricated as the specimen and was used to validate the active sensing methods.
      Lead Zirconate Titanate (PZT) patches were used as sensors and actuators to
      monitor the bolted spherical joint tightness status. One PZT patch mounted on the
      central bolted sphere at the upper chord was used as an actuator to generate a
      stress wave. Another PZT patch mounted on the bar was used as a sensor to detect
      the propagated waves through the bolted spherical connection. The looseness of
      the connection can impact the energy of the stress wave propagated through the
      connection. The wavelet packet analysis and time reversal (TR) method were used
      to quantify the energy of the transmitted signal between the PZT patches by which
      the tightness status of the connection can be detected. In order to verify the
      effectiveness, repeatability, and consistency of the proposed methods, the
      experiments were repeated six times in different bolted spherical connection
      positions. The experimental results showed that the wavelet packet analysis and
      TR method are effective in detecting the tightness status of the connections. The
      proposed active monitoring method using PZT transducers can monitor the tightness
      levels of bolted spherical joint connections efficiently and shows its potential
      to guarantee the safety of space steel structures in construction and service.

PMID- 29843370
TI  - Antiproliferative Phenothiazine Hybrids as Novel Apoptosis Inducers against MCF-7
      Breast Cancer.
AB  - We designed a series of novel phenothiazine-1,2,3-triazole hybrids by the
      molecular hybridization strategy and evaluated their antiproliferative activity
      against three cancer cell lines (MDA-MB-231, MDA-MB-468 and MCF-7). For the
      structure-activity relationships, the importance of 1,2,3-triazole and
      substituents on phenyl ring was explored. Among these phenothiazine-1,2,3
      triazole hybrids, compound 9f showed the most potent inhibitory effect against
      MCF-7 cells, with an IC50 value of 0.8 MUM. Importantly, compound 9f could induce
      apoptosis against MCF-7 cells by regulating apoptosis-related proteins (Bcl-2,
      Bax, Bad, Parp, and DR5). These potent phenothiazine-1,2,3-triazole hybrids as
      novel apoptosis inducers might be used as antitumor agents in the future.

PMID- 29843371
TI  - Strategies for Enhancing the Permeation of CNS-Active Drugs through the Blood
      Brain Barrier: A Review.
AB  - Background: The blood brain barrier (BBB) is a dynamic and functional structure
      which poses a vast challenge in the development of drugs acting on the central
      nervous system (CNS). While most substances are denied BBB crossing, selective
      penetration of substances mainly occurs through diffusion, carrier mediated
      transport, or receptor mediated transcytosis. Methods: Strategies in enhancing
      BBB penetration have been reviewed and summarized in accordance with their type
      of formulation. Highlights in monoclonal antibodies, peptide-vectors,
      nanoparticles, and simple prodrugs were included. Conclusion: Nanoparticles and
      simple prodrugs, for example, can be used for efficient BBB penetration through
      inhibition of efflux mechanisms, however, monoclonal antibodies are the most
      promising strategy in BBB penetration. Close follow-up of future development in
      this area should confirm our expectation.

PMID- 29843373
TI  - Energy Modeling of IoT Mobile Terminals on WiFi Environmental Impacts ?.
AB  - With the popularity of various IoT mobile terminals such as mobile phones and
      sensors, the energy problems of IoT mobile terminals have attracted increasingly
      more attention. In this paper, we explore the impacts of some important factors
      of WiFi environments on the energy consumption of mobile phones, which are
      typical IoT end devices. The factors involve the WiFi signal strength under good
      signal conditions, the type and the amount of protocol packets that are initiated
      by WiFi APs (Access Points) to maintain basic network communication with the
      phones. Controlled experiments are conducted to quantitatively study the phone
      energy impacts by the above WiFi environmental factors. To describe such impacts,
      we construct a time-based signal strength-aware energy model and packet
      type/amount-aware energy models. The models constructed in the paper corroborate
      the following user experience on phone energy consumption: (1) a phone's energy
      is drawn faster under higher WiFi signal strengths than under lower ones even in
      normal signal conditions; (2) phones consume energy faster in a public WiFi
      network than in a private one even in the basic phone state. The energy modeling
      methods proposed in the paper enable ordinary developers to analyze phone energy
      draw conveniently by utilizing inexpensive power meters as measurement tools. The
      modeling methods are general and are able to be used for phones of any type and
      any platform.

PMID- 29843372
TI  - Assisted Tip Sonication Approach for Graphene Synthesis in Aqueous Dispersion.
AB  - Graphene (G) is a newcomer material that holds promising properties for many
      applications. The production of high quality G with a good yield is a long
      standing goal for many researchers. This work emphasizes synthesis of dispersed
      graphene nanoplatelets (DGP) through aqueous dispersion technique in
      surfactant/water solution with the aid of tip sonication. A chemical method was
      also used to prepare graphene oxide (GO) and reduced graphene oxide (RGO) for
      comparison. Elemental analysis revealed the C:O ratio to be 12:1 for DGP but much
      lower for other graphene structures. Optical characterization of DGP, GO and RGO
      with UV and Raman spectroscopy confirmed the ideal structure of DGP. Moreover, X
      ray diffraction (XRD) revealed the amorphous structure of DGP. Transmission
      electron microscope (TEM) imaging showed that DGP was composed of a few flat
      layers, unlike the wrinkled and partially bent multilayered G. Topological study
      of the DGP surface with scanning electron microscope (SEM) depicted its rough
      surface with (ra) value of 35 nm, as revealed using an atomic force microscope
      (AFM). Electrochemical measurements confirmed the higher conductivity of DGP over
      graphene prepared by chemical method due to lack of structural defects. Its
      perfect structure facilitates the mobility of charge carriers that makes it
      preferable in optoelectronic applications.

PMID- 29843374
TI  - Miniaturized Sensors Registering the Long-Term Course of Suture Tension In Vivo
      under Varying Intra-Abdominal Pressure.
AB  - BACKGROUND: Failure of laparotomy closure develops after up to 20% of abdominal
      operations. Suture tension has an influence on the quality of tissue
      regeneration. No sensors are available to register suture tension dynamics in
      vivo. METHODS: In a series of animal experiments, the effect of suture tension on
      the ultrastructure of the healing incision was examined. Surgeons' ability to
      suture with target tension was tested. An implantable sensor and data logger were
      developed and tested experimentally in sutures closing midline laparotomies in
      pigs both under normal and elevated intra-abdominal pressure. RESULTS: High
      suture tension has a negative influence on the regeneration of laparotomy
      incisions. Running sutures for laparotomy closure lose 45% of their initial
      tension over periods of 23 h. Intermittent elevation of intra-abdominal pressure
      to 30 mm Hg leads to a near total loss of suture tension after 23 h. CONCLUSION:
      Surgeons are not able to control and reproduce suture tension. Suture tension
      dynamics can be measured in vivo by the sensor developed. Further research is
      needed to define a tissue-specific suture tension optimum to reduce the incidence
      of complications after laparotomy. Techniques for laparotomy closure need to be
      modified.

PMID- 29843375
TI  - Benzothiadiazole and B-Aminobutyricacid Induce Resistance to Ectropis Obliqua in
      Tea Plants (Camellia Sinensis (L.) O. Kuntz).
AB  - In order to investigate the effect of benzothiadiazole (BTH) and beta
      aminobutyric acid (BABA) on the resistance of tea plants (Camellia sinensis) to
      tea geometrid (Ectropis obliqua), three levels each of benzothiadiazole (BTH) and
      beta-aminobutyric acid (BABA) were sprayed on 10-year-old tea plants. Generally
      PPO and PAL activities increased with low concentrations of BTH and BABA
      treatments. Quantitative RT-PCR revealed a 1.43 and 2.72-fold increase in PPO
      gene expression, and 3.26 and 3.99-fold increase in PAL gene expression with 75
      mg/L BTH and 400 mg/L BABA respectively. Analysis of hydrolysis of synthetic
      substrates also revealed that chymotrypsin-like enzyme activity present in larval
      midgut extracts was not significantly inhibited by BTH and BABA. However,
      proteinase activity was found to be inversely proportional to the age of tea
      geometrid. Larvae pupation rate decreased by 8.10, 10.81 and 21.62% when tea
      geometrid were fed with leaves treated with 25, 50 and 75 mg/L BTH solutions,
      while 100, 200 and 400 mg/L BABA solutions decreased same by 8.10, 16.21 and
      13.51% respectively. Also, larvae development period delayed to 23.33 and 26.33
      days with 75 mg/L BTH and 400 mg/L BABA treatments respectively. The results in
      this study; therefore, suggest that benzothiadiazole (BTH) and beta-aminobutyric
      acid (BABA) play a role in inducing resistance in tea plants to tea geometrid,
      with the optimal effect achieved at BTH-3 (75 mg/L) and BABA-3 (400 mg/L),
      respectively.

PMID- 29843376
TI  - Influence of Surface Defects and Size on Photochemical Properties of SnO2
      Nanoparticles.
AB  - We report the successful synthesis of surface defective small size (SS) SnO2
      nanoparticles (NPs) by adopting a low temperature surfactant free solution
      method. The structural properties of the NPs were analyzed using X-ray
      diffraction (XRD), field emission scanning electron microscopy (FESEM), and
      transmission electron microscopy (TEM). The presence of surface defects,
      especially oxygen vacancies, in the sample were characterized using micro-Raman
      spectroscopy, X-ray photoelectron spectroscopy (XPS), and photoluminescence
      emission. The Brunauer-Emmet-Teller (BET) nitrogen adsorption-desorption
      isotherms demonstrated the superior textural properties (high surface area and
      uniform pore size) of SS SnO2 compared to large size (LS) SnO2. A comparable
      study was drawn between SS SnO2 and LS SnO2 NPs and a significant decrease in the
      concentration of surface defects was observed for the LS sample. The results
      showed that surface defects significantly depend upon the size of the NPs. The
      surface defects formed within the band gap energy level of SnO2 significantly
      participated in the recombination process of photogenerated charge carriers,
      improving photochemical properties. Moreover, the SS SnO2 showed superior
      photoelectrochemical (PEC) and photocatalytic activities compared to the LS SnO2.
      The presence of a comparatively large number of surface defects due to its high
      surface area may enhance the photochemical activity by reducing the recombination
      rate of the photogenerated charges.

PMID- 29843377
TI  - Weight Concerns and Use of Cigarettes and E-Cigarettes among Young Adults.
AB  - Higher weight concerns have been associated with higher cigarette smoking,
      particularly among women, partly because smoking is perceived to limit appetite
      for food. E-cigarettes are increasingly used as an alternative to combustible
      cigarettes and are widely believed to be less harmful than cigarettes. Currently
      it is not known whether weight concerns are associated with e-cigarette use among
      young adults. In this study, we tested the association between weight concerns
      and cigarette and e-cigarette use and use susceptibility among young adults.
      Cross-sectional data were collected from college students (N = 470; M age = 20.9;
      SD = 2.1; 65% women). Results indicated that weight concerns were significantly
      associated with lifetime and current cigarette smoking status, current cigarette
      smoking frequency and cigarette use susceptibility (among never smokers),
      adjusting for demographics variables. Weight concerns were not associated with
      lifetime or current e-cigarette use status or e-cigarette use susceptibility,
      adjusting for demographics and cigarette use status. However, higher weight
      concerns were associated with higher frequency of current e-cigarette use,
      adjusting for demographic variables and current cigarette smoking frequency.
      These findings imply that even though weight concerns may not motivate e
      cigarette use as strongly as cigarette use, weight concerns may influence higher
      intensity of e-cigarette use among users.

PMID- 29843378
TI  - Comments to: A Novel Low-Cost Instrumentation System for Measuring the Water
      Content and Apparent Electrical Conductivity of Soils, Sensors, 15, 25546-25563.
AB  - The article comments on claims made by Rego et al. about the sensor they
      developed to determine soil water content and its salinity via the admittance
      measurement of electrodes embedded in the soil. Their sensor is not based on a
      self-balanced bridge, as stated, but on a more common technique relying on Ohm's
      law. A bridge is a zero method of measurement which can provide direct voltages
      proportional to soil permittivity and conductivity with a high resolution. Thanks
      to modern electronics the method can be adapted for fast and continuous
      monitoring in a remote site. Because of this confusion about the different
      measurement techniques among available admittance or capacitance sensors, we give
      a succinct review of them and indicate how they compare to the two techniques
      under discussion. We also question the ability of Rego et al.'s current sensor to
      determine both soil water content and salinity due first to instrument biases and
      then to the soil complexity as a dielectric medium. In particular, the choice of
      sensor frequencies is crucial in the two steps. In addition, the procedure to
      determine and account for temperature influences on readings is not presented
      clearly enough. It is important to distinguish between the effect resulting from
      electronics sensitivity, and those that are soil-specific. The comment does not
      invalidate the design of the sensor, but indicates points, especially parasitic
      contributions, which must be dealt with to avoid major errors.

PMID- 29843379
TI  - Which Patients Are Prescribed Escitalopram?: Predictors for Escitalopram
      Prescriptions and Functional Outcomes among Patients with Acute Ischemic Stroke.
AB  - Recent studies have demonstrated that antidepressants could enhance functional
      recovery via neuroplasticity beyond solely treating depression. However, since
      Koreans typically show a greater aversion to seeking psychiatric care than
      citizens of Western countries, the number of antidepressant prescriptions is low.
      Through this study, we aim to identify the factors that lead to the prescription
      of antidepressants in subjects with acute ischemic stroke (AIS) in clinical
      practice. A total of 775 patients with ischemic stroke (IS) participated in this
      study from March 2010 to May 2013. We used binary logistic regression to find
      predictors for escitalopram prescriptions. To reveal predictors for short-term
      functional outcomes, we used an adjusted regression model using a propensity
      score. Among the 775 participants, 39 (5.03%) were prescribed escitalopram. The
      duration of hospital stay (odds ratio (OR) = 1.07; 95% confidence interval (CI) =
      1.04-1.10) and the use of mechanical ventilation were significantly more closely
      related to escitalopram prescriptions as compared to non-escitalopram
      prescriptions (OR = 5.15; 95% CI = 1.53-17.40). The use of escitalopram, on the
      other hand, was not significantly associated with short-term functional outcomes
      (OR = 1.27; 95% CI = 0.50-3.25). Duration of hospital stay and use of mechanical
      ventilation were significantly related to escitalopram prescriptions.

PMID- 29843380
TI  - Protective Effect of Selenium-Enriched Ricegrass Juice against Cadmium-Induced
      Toxicity and DNA Damage in HEK293 Kidney Cells.
AB  - Cadmium (Cd) contamination in food is a problem endangering human health. Cd
      detoxication is an interesting topic particularly using food which provides no
      side effects. Ricegrass juice is a squeezed juice from young rice leaves which is
      introduced as a functional drink rich in polyphenol components. Se-enrichment
      into ricegrass is initiated to provide extra advantages of their functional
      properties. The protective role of ricegrass juice (RG) and Se-enriched ricegrass
      juice (Se-RG) against Cd toxicity during pre-, co- and post-treatment on HEK293
      kidney cells were investigated. Results confirmed that RG and Se-RG had very low
      toxicity for kidney cells. Both extracts showed a protective role during pre
      treatment and co-treatment against Cd toxicity by exerting a reduction in
      malondialdehyde (MDA) content and the percentage of DNA damage in tail and tail
      length of the comets over the Cd-treated cells. However, the Se-RG indicated
      additional benefits in all properties over RG. High Se content in Se-RG resulted
      in more protective effects of the regular ricegrass juice. In summary, this study
      provides clear evidence that Se-enriched ricegrass juice has potential to be
      developed as a functional food to protect the human body from Cd contamination
      via the reduction of oxidative stress and DNA damage.

PMID- 29843381
TI  - Elevated LV Mass and LV Mass Index Sign on the Athlete's ECG: Athletes' Hearts
      are Prone to Ventricular Arrhythmia.
AB  - OBJECTIVES: Intense exercise elevates all heart chambers' dimensions, left
      ventricular mass (LV mass), and left ventricular mass index (LV mass index). The
      relationship between increased ventricular arrhythmias and sudden cardiac death
      with LV dilatation and elevated LV mass has been previously demonstrated. We
      investigated whether sports-related LV dilatation and elevated LV mass and LV
      mass index cause an increase in ventricular repolarization heterogeneity.
      PATIENTS AND METHODS: This prospective observational study recruited 565
      participants. There were 226 (female: 28) athletes and 339 (female: 45) healthy
      controls between 17 and 42 years of age. They were evaluated using 12-lead
      electrocardiography and transthoracic echocardiography. Electrocardiograms were
      obtained at a rate of 50 mm/s and an amplitude of 10 mV, including at least 3 QRS
      complexes for each derivation. They were taken with 12 standard deviations.
      Transmural dispersion of repolarization indexes (TDR) (Tp-Te interval, Tp-Te/QT
      ratio and Tp-Te/QTc ratio, Tp-Te(d)) were measured from precordial derivations.
      Measurements weretakenwith a program which was generated with MATLAB codes.
      RESULTS: Tp-Te interval, Tp-Te/QT ratio, Tp-Te/QTc ratio, Tp-Te(d), PW (posterior
      wall thickness), IVS (interventricular septal thickness), LVEDD (left ventricular
      end-diastolic diameter), LV mass (left ventricular mass), and LV mass index (left
      ventricular mass index) for the athlete group were significantly higher than for
      the control group. Correlation analyses revealed that TDR indexes significantly
      correlated with PW, IVS, LVEDD, LV mass, and LV mass index. CONCLUSION: LV mass
      and LV mass index increase in well-trained athletes, and this increase leads to
      an increase in TDR indexes. The increased frequency of ventricular arrhythmia and
      sudden cardiac death may be explained with increasing ventricular repolarization
      heterogeneity in these individuals.

PMID- 29843382
TI  - Tensile, Quasistatic and Dynamic Fracture Properties of Nano-Al2O3-Modified Epoxy
      Resin.
AB  - Epoxy resin, modified with different particle sizes (50 nm, 100 nm, 200 nm) and
      contents (1 wt %, 3 wt %, 5 wt %, 7 wt %) was manufactured. The mechanical
      behaviors of tensile, quasistatic fracture and dynamic fracture under SHPB (split
      Hopkinson pressure bar) loading were investigated. The dynamic fracture behaviors
      of the composites were evaluated by 2D-DIC (digital image correlation) and the
      strain gauge technique, and the fracture surface was examined by SEM (scanning
      electron microscope). According to the results, the tensile modulus and strength
      significantly increased for epoxy resin modified with 5 wt % Al2O3 of 50 nm. The
      quasistatic fracture toughness of modified epoxy resin increased with the
      particle content. However, the fracture toughness of epoxy resin modified with
      high content fillers decreased for particle agglomeration that existed in epoxy
      resin. The crack propagation velocity can be decreased for epoxy resin modified
      with particles under dynamic loading. The dynamic initiation fracture toughness
      of modified epoxy resin increases with both particle size and content, but when
      the fillers have a high content, the particle size effects are weak. For the
      composite under dynamic loading conditions, the toughening mechanism is also
      affected by particle size.

PMID- 29843383
TI  - CRISPR-Mediated Reactivation of DKK3 Expression Attenuates TGF-beta Signaling in
      Prostate Cancer.
AB  - The DKK3 gene encodes a secreted protein, Dkk-3, that inhibits prostate tumor
      growth and metastasis. DKK3 is downregulated by promoter methylation in many
      types of cancer, including prostate cancer. Gene silencing studies have shown
      that Dkk-3 maintains normal prostate epithelial cell homeostasis by limiting TGF
      beta/Smad signaling. While ectopic expression of Dkk-3 leads to prostate cancer
      cell apoptosis, it is unclear if Dkk-3 has a physiological role in cancer cells.
      Here, we show that treatment of PC3 prostate cancer cells with the DNA
      methyltransferase (DNMT) inhibitor decitabine demethylates the DKK3 promoter,
      induces DKK3 expression, and inhibits TGF-beta/Smad-dependent transcriptional
      activity. Direct induction of DKK3 expression using CRISPR-dCas9-VPR also
      inhibited TGF-beta/Smad-dependent transcription and attenuated PC3 cell migration
      and proliferation. These effects were not observed in C4-2B cells, which do not
      respond to TGF-beta. TGF-beta signals can regulate gene expression directly via
      SMAD proteins and indirectly by increasing DNMT expression, leading to promoter
      methylation. Analysis of genes downregulated by promoter methylation and
      predicted to be regulated by TGF-beta found that DKK3 induction increased
      expression of PTGS2, which encodes cyclooxygenase-2. Together, these observations
      provide support for using CRISPR-mediated induction of DKK3 as a potential
      therapeutic approach for prostate cancer and highlight complexities in Dkk-3
      regulation of TGF-beta signaling.

PMID- 29843384
TI  - Alcoholism: A Multi-Systemic Cellular Insult to Organs.
AB  - Alcohol abuse can affect more than the heart and the liver. Many observers often
      do not appreciate the complex and differing aspects of alcohol's effects in
      pathophysiologies that have been reported in multiple organs. Chronic alcohol
      abuse is known to be associated with pathophysiological changes that often result
      in life-threatening clinical outcomes, e.g., breast and colon cancer, pancreatic
      disease, cirrhosis of the liver, diabetes, osteoporosis, arthritis, kidney
      disease, immune system dysfunction, hypertension, coronary artery disease,
      cardiomyopathy, and can be as far-reaching as to cause central nervous system
      disorders. In this review article, we will discuss the various organs impacted by
      alcohol abuse. The lack of clear guidelines on the amount and frequency of
      alcohol intake, complicated by personal demographics, make extrapolations to real
      life practices at best difficult for public health policy-makers.

PMID- 29843385
TI  - Design of Compressed Sensing Algorithm for Coal Mine IoT Moving Measurement Data
      Based on a Multi-Hop Network and Total Variation.
AB  - As the application of a coal mine Internet of Things (IoT), mobile measurement
      devices, such as intelligent mine lamps, cause moving measurement data to be
      increased. How to transmit these large amounts of mobile measurement data
      effectively has become an urgent problem. This paper presents a compressed
      sensing algorithm for the large amount of coal mine IoT moving measurement data
      based on a multi-hop network and total variation. By taking gas data in mobile
      measurement data as an example, two network models for the transmission of gas
      data flow, namely single-hop and multi-hop transmission modes, are investigated
      in depth, and a gas data compressed sensing collection model is built based on a
      multi-hop network. To utilize the sparse characteristics of gas data, the concept
      of total variation is introduced and a high-efficiency gas data compression and
      reconstruction method based on Total Variation Sparsity based on Multi-Hop (TVS
      MH) is proposed. According to the simulation results, by using the proposed
      method, the moving measurement data flow from an underground distributed mobile
      network can be acquired and transmitted efficiently.

PMID- 29843386
TI  - Precision Agriculture Design Method Using a Distributed Computing Architecture on
      Internet of Things Context.
AB  - The Internet of Things (IoT) has opened productive ways to cultivate soil with
      the use of low-cost hardware (sensors/actuators) and communication (Internet)
      technologies. Remote equipment and crop monitoring, predictive analytic, weather
      forecasting for crops or smart logistics and warehousing are some examples of
      these new opportunities. Nevertheless, farmers are agriculture experts but,
      usually, do not have experience in IoT applications. Users who use IoT
      applications must participate in its design, improving the integration and use.
      In this work, different industrial agricultural facilities are analysed with
      farmers and growers to design new functionalities based on IoT paradigms
      deployment. User-centred design model is used to obtain knowledge and experience
      in the process of introducing technology in agricultural applications. Internet
      of things paradigms are used as resources to facilitate the decision making. IoT
      architecture, operating rules and smart processes are implemented using a
      distributed model based on edge and fog computing paradigms. A communication
      architecture is proposed using these technologies. The aim is to help farmers to
      develop smart systems both, in current and new facilities. Different decision
      trees to automate the installation, designed by the farmer, can be easily
      deployed using the method proposed in this document.

PMID- 29843387
TI  - The Effect of Overexpressed DdRabS on Development, Cell Death, Vesicular
      Trafficking, and the Secretion of Lysosomal Glycosidase Enzymes.
AB  - Rab GTPases are essential regulators of many cellular processes and play an
      important role in downstream signaling vital to proper cell function. We sought
      to elucidate the role of novel D. discoideum GTPase RabS. Cell lines over
      expressing DdRabS and expressing DdRabS N137I (dominant negative (DN)) proteins
      were generated, and it was determined that DdRabS localized to endosomes, ER
      Golgi membranes, and the contractile vacuole system. It appeared to function in
      vesicular trafficking, and the secretion of lysosomal enzymes. Interestingly,
      microscopic analysis of GFP-tagged DdRabS (DN) cells showed differential
      localization to lysosomes and endosomes compared to GFP-tagged DdRabS
      overexpressing cells. Both cell lines over-secreted lysosomal glycosidase
      enzymes, especially beta-glucosidase. Furthermore, DdRabS overexpressing cells
      were defective in aggregation due to decreased cell-cell cohesion and sensitivity
      to cAMP, leading to abnormal chemotactic migration, the inability to complete
      development, and increased induced cell death. These data support a role for
      DdRabS in trafficking along the vesicular and biosynthetic pathways. We
      hypothesize that overexpression of DdRabS may interfere with GTP activation of
      related proteins essential for normal development resulting in a cascade of
      defects throughout these processes.

PMID- 29843388
TI  - Relationship between Body Mass Index, Cardiorespiratory and Musculoskeletal
      Fitness among South African Adolescent Girls.
AB  - Background: Cardiorespiratory and musculoskeletal fitness are important health
      indicators that support optimal physical functioning. Understanding the
      relationship between body mass index and these health markers may contribute to
      the development of evidence-based interventions to address obesity-related
      complications. The relationship between body mass index, cardiorespiratory and
      musculoskeletal fitness has not been well explored, particularly in female
      adolescents. The aim of this study was to investigate the association between
      body mass index, cardiorespiratory and musculoskeletal fitness among South
      African adolescent girls in low-income communities. Methods: This cross-sectional
      study included 151 adolescent girls, aged 13-16 years. Cardiorespiratory fitness
      was measured using the 20 m shuttle run test and musculoskeletal fitness was
      assessed using a variety of field-based tests. Height and weight were measured
      with standardised procedures and body mass index (BMI) was derived by the formula
      [BMI = weight (kg)/height (m)2]. Participants were categorised into three BMI
      groups using the International Obesity Task Force age- and gender-specific cut
      off points. Pearson correlations were used to determine the association between
      body mass index, cardiorespiratory fitness and measures of musculoskeletal
      fitness at p <= 0.05. Results: Overweight and obese girls were found to have
      lower cardiorespiratory fitness, decreased lower extremity muscular strength,
      greater grip strength, and more hypermobile joints compared to normal-weight
      peers. BMI was negatively associated with cardiorespiratory fitness and lower
      extremity muscular strength. Conclusions: The findings indicate that increased
      body mass correlates with decreased cardiorespiratory and musculoskeletal
      fitness. Interventions should be developed to target these important components
      of physical fitness in this demographic group.

PMID- 29843389
TI  - Environmental Lead Exposure and Adult Literacy in Myanmar: An Exploratory Study
      of Potential Associations at the Township Level.
AB  - Environmental lead exposure is a population health concern in many low- and
      middle-income countries. Lead is found throughout Myanmar and prior to the 1940s
      the country was the largest producer of lead worldwide. The aim of this study was
      to examine any potential association between lead mining and adult literacy rates
      at the level of 330 townships in Myanmar. Townships were identified as lead or
      non-lead mining areas and 2015 census data were examined with association being
      identified using descriptive, analytical and spatial statistical methods.
      Overall, there does appear to be a significant relationship between lead mining
      activity and adult literacy levels among townships with both low access (p =
      0.05; OR = 2.701 (1.136-6.421)) as well with high access to safe sanitation (p =
      0.01; OR = 18.40 (1.794-188.745)). Local Indicators of Spatial Association (LISA)
      cluster maps confirm these findings. This exploratory analysis is a first step in
      the examination of potential environmental lead exposure and its implications in
      Myanmar.

PMID- 29843390
TI  - A Capsule-Type Electromagnetic Acoustic Transducer for Fast Screening of External
      Corrosion in Nonmagnetic Pipes.
AB  - For fuel transmission and structural strengthening, small-diameter pipes of
      nonmagnetic materials are extensively adopted in engineering fields including
      aerospace, energy, transportation, etc. However, the hostile and corrosive
      environment leaves them vulnerable to external corrosion which poses a severe
      threat to structural integrity of pipes. Therefore, it is imperative to
      nondestructively detect and evaluate the external corrosion in nonmagnetic pipes.
      In light of this, a capsule-type Electromagnetic Acoustic Transducer (EMAT) for
      in-situ nondestructive evaluation of nonmagnetic pipes and fast screening of
      external corrosion is proposed in this paper. A 3D hybrid model for efficient
      prediction of responses from the proposed transducer to external corrosion is
      established. Closed-form expressions of field quantities of electromagnetics and
      EMAT signals are formulated. Simulations based on the hybrid model indicate
      feasibility of the proposed transducer in detection and evaluation of external
      corrosion in nonmagnetic pipes. In parallel, experiments with the fabricated
      transducer have been carried out. Experimental results are supportive of the
      conclusion drawn from simulations. The investigation via simulations and
      experiments implies that the proposed capsule-type EMAT is capable of fast
      screening of external corrosion, which is beneficial to the in-situ
      nondestructive evaluation of small-diameter nonmagnetic pipes.

PMID- 29843392
TI  - Evaluation of Self-Propelled High-Energy Ultrasonic Atomizer on Azoxystrobin and
      Tebuconazole Application in Sunlit Greenhouse Tomatoes.
AB  - In this study, a self-propelled high-energy ultrasonic atomizer was evaluated in
      terms of deposition on the canopy, the loss to the ground, and fungicide residues
      in cherry tomato and tomato. Artificial collectors fixed to the upper side and
      underside of the leaves at different depths and heights were used to collect the
      depositions. A reliable analytical method for determination of azoxystrobin and
      tebuconazole in artificial collectors and residue samples was developed by using
      liquid chromatography triple-quadrupole mass spectrometry. The results showed
      that the atomizer distributed the droplets evenly throughout the greenhouse with
      good uniformity (CVs below 39%). The ratio of depositions on the internal and
      external sides was 66-83%, and the ratio of depositions on the underside and
      upper side was 39-50%. There were no significant differences in depositions
      between two different height crops. The residues of azoxystrobin and tebuconazole
      in tomato and cherry tomato fruits were far below the maximum residue limits at
      harvest time. In general, self-propelled high-energy ultrasonic atomizer used in
      a greenhouse could increase the depositions, especially on the underside and
      internal side of the canopies, and lead to a reduction of operator exposure risk.

PMID- 29843393
TI  - Comparing Palm Oil, Tocotrienol-Rich Fraction and alpha-Tocopherol
      Supplementation on the Antioxidant Levels of Older Adults.
AB  - BACKGROUND: Tocotrienol and tocopherol are known to prevent numerous degenerative
      diseases. The aim of this study is to compare the effects of tocotrienol-rich
      fraction (TRF) with alpha-tocopherol (alpha-TF) on the antioxidant status of
      healthy individuals aged between 50 and 55 years. METHODS: Volunteers were
      divided into groups receiving placebo (n = 23), alpha-TF (n = 24) and TRF (n =
      24). Fasting venous blood samples were taken at baseline (0 month), 3 months and
      6 months of supplementation for the determination of superoxide dismutase (SOD),
      catalase (CAT), and glutathione peroxidase (GPx) activities as well as for
      reduced glutathione (GSH) and oxidized glutathione (GSSG) concentrations.
      RESULTS: CAT and GPx were unaffected by TRF and alpha-TF supplementations. SOD
      activity increased significantly after six months of TRF supplementation.
      Analysis by gender showed that only female subjects had significant increases in
      SOD and GPx activities after six months of TRF supplementation. GPx activity was
      also significantly higher in females compared to males after six months of TRF
      supplementation. The GSH/GSSG ratio increased significantly after six months of
      TRF and alpha-TF supplementation in only the female subjects. CONCLUSION: TRF and
      alpha-TF supplementation exhibited similar effects to the antioxidant levels of
      older adults with TRF having more significant effects in females.

PMID- 29843391
TI  - Phage Therapy: What Have We Learned?
AB  - In this article we explain how current events in the field of phage therapy may
      positively influence its future development. We discuss the shift in position of
      the authorities, academia, media, non-governmental organizations, regulatory
      agencies, patients, and doctors which could enable further advances in the
      research and application of the therapy. In addition, we discuss methods to
      obtain optimal phage preparations and suggest the potential of novel applications
      of phage therapy extending beyond its anti-bacterial action.

PMID- 29843394
TI  - Racial Disparities and Preventive Measures to Renal Cell Carcinoma.
AB  - Kidney cancer ranks among the top 10 cancers in the United States. Although it
      affects both male and female populations, it is more common in males. The
      prevalence rate of renal cell carcinoma (RCC), which represents about 85% of
      kidney cancers, has been increasing gradually in many developed countries. Family
      history has been considered as one of the most relevant risk factors for kidney
      cancer, although most forms of an inherited predisposition for RCC only account
      for less than four percent. Lifestyle and other factors such as occupational
      exposure, high blood pressure, poor diet, and heavy cigarette smoking are highly
      associated with its incidence and mortality rates. In the United States, White
      populations have the lowest prevalence of RCC compared to other ethnic groups,
      while Black Americans suffer disproportionally from the adverse effects of RCC.
      Hence, this review article aims at identifying the major risk factors associated
      with RCC and highlighting the new therapeutic approaches for its
      control/prevention. To achieve this specific aim, articles in peer-reviewed
      journals with a primary focus on risk factors related to kidney cancer and on
      strategies to reduce RCC were identified. The review was systematically conducted
      by searching the databases of MEDLINE, PUBMED Central, and Google Scholar
      libraries for original articles. From the search, we found that the incidence and
      mortality rates of RCC are strongly associated with four main risk factors,
      including family history (genetics), lifestyle (poor diet, cigarette smoking,
      excess alcohol drinking), environment (community where people live), and
      occupation (place where people work). In addition, unequal access to improvement
      in RCC cancer treatment, limited access to screening and diagnosis, and limited
      access to kidney transplant significantly contribute to the difference observed
      in survival rate between African Americans and Caucasians. There is also
      scientific evidence suggesting that some physicians contribute to racial
      disparities when performing kidney transplant among minority populations. New
      therapeutic measures should be taken to prevent or reduce RCC, especially among
      African Americans, the most vulnerable population group.

PMID- 29843395
TI  - Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics
      Prospect.
AB  - Mycobacterium tuberculosis is one of the deadliest human pathogen of the
      tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant
      and extremely drug resistant strains of M. tuberculosis. Apart from principal
      targets of resistance, many explanations have been proposed for drug resistance
      but some resistance mechanisms are still unknown. Recently approved line probe
      assay (LPA) diagnostics for detecting the resistance to first and second line
      drugs are unable to diagnose the drug resistance in M. tuberculosis isolates
      which do not have the mutations in particular genes responsible for resistance.
      Proteomics and bioinformatic tools emerged as direct approaches for
      identification and characterization of novel proteins which are directly and
      indirectly involved in drug resistance that could be used as potential targets in
      future. In future, these novel targets might reveal new mechanism of resistance
      and can be used in diagnostics or as drug targets.

PMID- 29843396
TI  - Dietary Nutrients and Bioactive Substances Modulate Heat Shock Protein (HSP)
      Expression: A Review.
AB  - Interest in the heat shock proteins (HSPs), as a natural physiological toolkit of
      living organisms, has ranged from their chaperone function in nascent proteins to
      the remedial role following cell stress. As part of the defence system, HSPs
      guarantee cell tolerance against a variety of stressors, including exercise,
      oxidative stress, hyper and hypothermia, hyper and hypoxia and improper diets.
      For the past couple of decades, research on functional foods has revealed a
      number of substances likely to trigger cell protection through mechanisms that
      involve the induction of HSP expression. This review will summarize the
      occurrence of the most easily inducible HSPs and describe the effects of dietary
      proteins, peptides, amino acids, probiotics, high-fat diets and other food
      derived substances reported to induce HSP response in animals and humans studies.
      Future research may clarify the mechanisms and explore the usefulness of this
      natural alternative of defense and the modulating mechanism of each substance.

PMID- 29843397
TI  - Hybrid Density Functional Study on the Photocatalytic Properties of Two
      dimensional g-ZnO Based Heterostructures.
AB  - In this work, graphene-like ZnO (g-ZnO)-based two-dimensional (2D)
      heterostructures (ZnO/WS2 and ZnO/WSe2) were designed as water-splitting
      photocatalysts based on the hybrid density functional. The dependence of
      photocatalytic properties on the rotation angles and biaxial strains were
      investigated. The bandgaps of ZnO/WS2 and ZnO/WSe2 are not obviously affected by
      rotation angles but by strains. The ZnO/WS2 heterostructures with appropriate
      rotation angles and strains are promising visible water-splitting photocatalysts
      due to their appropriate bandgap for visible absorption, proper band edge
      alignment, and effective separation of carriers, while the water oxygen process
      of the ZnO/WSe2 heterostructures is limited by their band edge positions. The
      findings pave the way to efficient g-ZnO-based 2D visible water-splitting
      materials.

PMID- 29843398
TI  - Reader Architectures for Wireless Surface Acoustic Wave Sensors.
AB  - Wireless surface acoustic wave (SAW) sensors have some unique features that make
      them promising for industrial metrology. Their decisive advantage lies in their
      purely passive operation and the wireless readout capability allowing the
      installation also at particularly inaccessible locations. Furthermore, they are
      small, low-cost and rugged components on highly stable substrate materials and
      thus particularly suited for harsh environments. Nevertheless, a sensor itself
      does not carry out any measurement but always requires a suitable excitation and
      interrogation circuit: a reader. A variety of different architectures have been
      presented and investigated up to now. This review paper gives a comprehensive
      survey of the present state of reader architectures such as time domain sampling
      (TDS), frequency domain sampling (FDS) and hybrid concepts for both SAW
      resonators and reflective SAW delay line sensors. Furthermore, critical
      performance parameters such as measurement accuracy, dynamic range, update rate,
      and hardware costs of the state of the art in science and industry are presented,
      compared and discussed.

PMID- 29843399
TI  - Persistence of Salmonella Typhimurium in Well Waters from a Rural Area of
      Changchun City, China.
AB  - Salmonella-contaminated well water could cause major infection outbreaks
      worldwide, thus, it is crucial to understand their persistence in those waters.
      In this study, we investigated the persistence of Salmonella enterica serovar
      Typhimurium in 15 well waters from a rural area of Changchun City, China. Results
      illustrated that the time to reach detection limit (ttd), first decimal reduction
      time (delta), and the shape parameter (p) ranged from 15 to 80 days, from 5.6 to
      66.9 days, and from 0.6 to 6.6, respectively. Principal component analysis showed
      that ttds of S. Typhimurium were positively correlated with total organic carbon,
      pH, NH4+-N, and total phosphate. Multiple stepwise regression analysis revealed
      that ttds could be best predicted by NH4+-N and pH. Canonical correspondence
      analysis and variation partition analysis revealed that NH4+-N and pH, and the
      rest of the water parameters, could explain 27.60% and 28.15% of overall
      variation of the survival behavior, respectively. In addition, ttds were found to
      be correlated (p < 0.01) with delta and p. Our results showed that the longer
      survival (>2.5 months) S. Typhimurium could constitute an increased health risk
      to the local communities, and provided insights into the close linkage between
      well water quality and survival of S. Typhimurium.

PMID- 29843400
TI  - The Impact of Industrial Odors on the Subjective Well-Being of Communities in
      Colorado.
AB  - Odor pollution was identified as a top priority of the community of North Denver.
      Previous studies that investigated the impact of air pollution in North Denver
      focused on adverse health effects, rather than mental well-being. This study
      assessed the impact of odors from industrial sources on the subjective well-being
      (SWB) of North Denver residents, and of four similar communities in Colorado for
      comparison. An online survey was sent to participants from Greeley, Fort Collins,
      Fort Lupton, North Denver, and Pueblo, asking questions about SWB and odors in
      their areas (n = 351). The evaluation of SWB was performed using a novel approach
      that appraises three aspects of SWB. This approach of evaluating SWB has not been
      used in odor exposure studies. A proportional odds logistic regression model was
      used to estimate nine measures of SWB. The results showed that participants who
      reported that the air is very fresh or the odor is highly acceptable had higher
      levels of SWB. This association suggests that residents who live in areas exposed
      to strong industrial odors had lower levels of SWB. A subset of participants in
      this study took the survey four times in one year. Longitudinal analysis showed
      that evaluative satisfaction was slightly associated with seasonality. Both
      satisfaction with how life turned out and satisfaction with standards of living
      slightly increased during the fourth quarter of the year. The study also found
      that four of the nine measures can be used to represent SWB in future studies.
      Two of those measures were evaluative SWB, and the other two were positive
      hedonic SWB measures. A comparison between the five communities showed that well
      being levels in North Denver and Greeley were not significantly different than
      those in Fort Collins or Fort Lupton. The comparison, however, showed that Pueblo
      had the lowest levels of well-being among all communities.

PMID- 29843402
TI  - Uncertainty and Motivation to Seek Information from Pharmacy Automated
      Communications.
AB  - Pharmacy personnel often answer telephones to respond to pharmacy customers
      (subjects) who received messages from automated systems. This research examines
      the communication process in terms of how users interact and engage with
      pharmacies after receiving automated messages. No study has directly addressed
      automated telephone calls and subjects' interactions. The purpose of this study
      is to test the interpersonal communication (IC) process of uncertainty in
      subjects in receipt of automated telephone calls ATCs from pharmacies. Subjects
      completed a survey of validated scales for Satisfaction (S); Relevance (R);
      Quality (Q); Need for Cognitive Closure (NFC). Relationships between S, R, Q,
      NFC, and subject preference to ATCs were analyzed to determine whether subjects
      contacting pharmacies display information seeking behavior. Results demonstrated
      that seeking information occurs if subjects: are dissatisfied with the content of
      the ATC; perceive that the Q of ATC is high and like receiving the ATC, or have a
      high NFC and do not like receiving ATCs. Other interactions presented
      complexities amongst uncertainty and tolerance of NFC within the IC process.

PMID- 29843401
TI  - Consensus in Gestational Diabetes MELLITUS: Looking for the Holy Grail.
AB  - The world's pre-eminent diabetes, obstetric, endocrine, and health organizations
      advocate a plethora of diverse algorithms for the screening, diagnosis,
      management, and follow-up of gestational diabetes mellitus (GDM). Additionally,
      there are regional recommendations of local health societies. Several of these
      proposals for GDM are contentious because some of them were developed from
      unscientific studies, based on expert-opinion, catered to preserve resources, and
      subjectively modified for convenience. Due to the wide variety of choices
      available, the approach to GDM can be extremely diverse even within the same
      hospital. This lack of consensus creates major problems in addressing prevalence,
      complications, efficacy of treatment, and follow-up of GDM. Moreover, it becomes
      nearly impossible to compare the numerous studies. Furthermore, the lack of
      consensus confuses the health care providers of obstetric health who look to the
      experts for guidance. Therefore, a clear, objective, "evidence-based" global
      approach, which is simple, easy to follow, and validated by corroborative
      research, is crucial. We contend that, despite decades of research, a single
      acceptable global guideline is not yet on the horizon.

PMID- 29843403
TI  - Neighborhood Socioeconomic Deprivation and Allostatic Load: A Scoping Review.
AB  - Residing in socioeconomically deprived neighborhoods may pose substantial
      physiological stress, which can then lead to higher allostatic load (AL), a
      marker of biological wear and tear that precedes disease. The aim of the present
      study was to map the current evidence about the relationship between neighborhood
      socioeconomic deprivation and AL. A scoping review approach was chosen to provide
      an overview of the type, quantity, and extent of research available. The review
      was conducted using three bibliographic databases (PubMed, SCOPUS, and Web of
      Science) and a standardized protocol. Fourteen studies were identified. Studies
      were predominantly from the USA, cross-sectional, focused on adults, and involved
      different races and ethnic groups. A wide range of measures of AL were
      identified: the mode of the number of biomarkers per study was eight but with
      large variability (range: 6-24). Most studies (n = 12) reported a significant
      association between neighborhood deprivation and AL. Behaviors and environmental
      stressors seem to mediate this relationship and associations appear more
      pronounced among Blacks, men, and individuals with poor social support. Such
      conclusions have important public health implications as they enforce the idea
      that neighborhood environment should be improved to prevent physiological
      dysregulation and consequent chronic diseases.

PMID- 29843404
TI  - Mechanistic Potential and Therapeutic Implications of Cannabinoids in
      Nonalcoholic Fatty Liver Disease.
AB  - Nonalcoholic fatty liver disease (NAFLD) is comprised of nonalcoholic fatty liver
      (NAFL) and nonalcoholic steatohepatitis (NASH). It is defined by histologic or
      radiographic evidence of steatosis in the absence of alternative etiologies,
      including significant alcohol consumption, steatogenic medication use, or
      hereditary disorders. NAFLD is now the most common liver disease, and when NASH
      is present it can progress to fibrosis and hepatocellular carcinoma. Different
      mechanisms have been identified as contributors to the physiology of NAFLD;
      insulin resistance and related metabolic derangements have been the hallmark of
      physiology associated with NAFLD. The mainstay of treatment has classically
      involved lifestyle modifications focused on the reduction of insulin resistance.
      However, emerging evidence suggests that the endocannabinoid system and its
      associated cannabinoid receptors and ligands have mechanistic and therapeutic
      implications in metabolic derangements and specifically in NAFLD. Cannabinoid
      receptor 1 antagonism has demonstrated promising effects with increased
      resistance to hepatic steatosis, reversal of hepatic steatosis, and improvements
      in glycemic control, insulin resistance, and dyslipidemia. Literature regarding
      the role of cannabinoid receptor 2 in NAFLD is controversial. Exocannabinoids and
      endocannabinoids have demonstrated some therapeutic impact on metabolic
      derangements associated with NAFLD, although literature regarding direct
      therapeutic use in NAFLD is limited. Nonetheless, the properties of the
      endocannabinoid system, its receptors, substrates, and ligands remain a
      significant arena warranting further research, with potential for a pharmacologic
      intervention for a disease with an anticipated increase in economic and clinical
      burden.

PMID- 29843405
TI  - Aspergoterpenins A-D: Four New Antimicrobial Bisabolane Sesquiterpenoid
      Derivatives from an Endophytic Fungus Aspergillus versicolor.
AB  - Aspergoterpenins A-D (1-4), four new bisabolane sesquiterpenoid derivatives, were
      obtained from the endophytic fungus, Aspergillus versicolor, together with eight
      known compounds (5-12), and their structures were elucidated by a comprehensive
      analysis of their NMR (Nuclear Magnetic Resonance), MS (Mass Spectrum) and CD
      (Circular Dichroism) spectra. Aspergoterpenin A (1) was the first example with a
      characteristic ketal bridged-ring part in the degraded natural bisabolane-type
      sesquiterpene structures. The compounds 1-12 displayed no significant activities
      against four cancer cell lines (A549, Caski, HepG2 and MCF-7). Further, the
      antimicrobial activities to Erwinia carotovora sub sp. Carotovora were evaluated,
      and the results showed that compounds 1-12 displayed antimicrobial activities
      with MIC values ranging from 15.2 to 85.2 MUg/mL.

PMID- 29843406
TI  - Therapeutics for Inflammatory-Related Diseases Based on Plasmon-Activated Water:
      A Review.
AB  - It is recognized that the properties of liquid water can be markedly different
      from those of bulk one when it is in contact with hydrophobic surfaces or is
      confined in nano-environments. Because our knowledge regarding water structure on
      the molecular level of dynamic equilibrium within a picosecond time scale is far
      from completeness all of water's conventionally known properties are based on
      inert "bulk liquid water" with a tetrahedral hydrogen-bonded structure. Actually,
      the strength of water's hydrogen bonds (HBs) decides its properties and
      activities. In this review, an innovative idea on preparation of metastable
      plasmon-activated water (PAW) with intrinsically reduced HBs, by letting
      deionized (DI) water flow through gold-supported nanoparticles (AuNPs) under
      resonant illumination at room temperature, is reported. Compared to DI water, the
      created stable PAW can scavenge free hydroxyl and 2,2-diphenyl-1-picrylhydrazyl
      radicals and effectively reduce NO release from lipopolysaccharide-induced
      inflammatory cells. Moreover, PAW can dramatically induce a major antioxidative
      Nrf2 gene in human gingival fibroblasts. This further confirms its cellular
      antioxidative and anti-inflammatory properties. In addition, innovatively
      therapeutic strategy of daily drinking PAW on inflammatory-related diseases based
      on animal disease models is demonstrated, examples being chronic kidney disease
      (CKD), chronic sleep deprivation (CSD), and lung cancer.

PMID- 29843407
TI  - Handling Complexity in Animal and Plant Science Research-From Single to
      Functional Traits: Are We There Yet?
AB  - The current knowledge of the main factors governing livestock, crop and plant
      quality as well as yield in different species is incomplete. For example, this
      can be evidenced by the persistence of benchmark crop varieties for many decades
      in spite of the gains achieved over the same period. In recent years, it has been
      demonstrated that molecular breeding based on DNA markers has led to advances in
      breeding (animal and crops). However, these advances are not in the way that it
      was anticipated initially by the researcher in the field. According to several
      scientists, one of the main reasons for this was related to the evidence that
      complex target traits such as grain yield, composition or nutritional quality
      depend on multiple factors in addition to genetics. Therefore, some questions
      need to be asked: are the current approaches in molecular genetics the most
      appropriate to deal with complex traits such as yield or quality? Are the current
      tools for phenotyping complex traits enough to differentiate among genotypes? Do
      we need to change the way that data is collected and analysed?

PMID- 29843408
TI  - Graphitized Carbon: A Promising Stable Cathode Catalyst Support Material for Long
      Term PEMFC Applications.
AB  - Stability of cathode catalyst support material is one of the big challenges of
      polymer electrolyte membrane fuel cells (PEMFC) for long term applications.
      Traditional carbon black (CB) supports are not stable enough to prevent oxidation
      to CO2 under fuel cell operating conditions. The feasibility of a graphitized
      carbon (GC) as a cathode catalyst support for low temperature PEMFC is
      investigated herein. GC and CB supported Pt electrocatalysts were prepared via an
      already developed polyol process. The physical characterization of the prepared
      catalysts was performed using transmission electron microscope (TEM), X-ray
      Powder Diffraction (XRD) and inductively coupled plasma optical emission
      spectrometry (ICP-OES) analysis, and their electrochemical characterizations were
      conducted via cyclic voltammetry(CV), rotating disk electrode (RDE) and potential
      cycling, and eventually, the catalysts were processed using membrane electrode
      assemblies (MEA) for single cell performance tests. Electrochemical impedance
      spectroscopy (EIS) and scanning electrochemical microscopy (SEM) have been used
      as MEA diagonostic tools. GC showed superior stability over CB in acid
      electrolyte under potential conditions. Single cell MEA performance of the GC
      supported catalyst is comparable with the CB-supported catalyst. A correlation of
      MEA performance of the supported catalysts of different Brunauer-Emmett-Teller
      (BET) surface areas with the ionomer content was also established. GC was
      identified as a promising candidate for catalyst support in terms of both of the
      stability and the performance of fuel cell.

PMID- 29843409
TI  - One-Step Hydrothermal Synthesis of Zeolite X Powder from Natural Low-Grade
      Diatomite.
AB  - Zeolite X powder was synthesized using natural low-grade diatomite as the main
      source of Si but only as a partial source of Al via a simple and green
      hydrothermal method. The microstructure and surface properties of the obtained
      samples were characterized by powder X-ray diffraction (XRD), scanning electron
      microscopy (SEM), wavelength dispersive X-ray fluorescence (XRF), calcium ion
      exchange capacity (CEC), thermogravimetric-differential thermal (TG-DTA)
      analysis, and N2 adsorption-desorption technique. The influence of various
      synthesis factors, including aging time and temperature, crystallization time and
      temperature, Na2O/SiO2 and H2O/Na2O ratio on the CEC of zeolite, were
      systematically investigated. The as-synthesized zeolite X with binary meso
      microporous structure possessed remarkable thermal stability, high calcium ion
      exchange capacity of 248 mg/g and large surface area of 453 m2/g. In addition,
      the calcium ion exchange capacity of zeolite X was found to be mainly determined
      by the crystallization degree. In conclusion, the synthesized zeolite X using
      diatomite as a cost-effective raw material in this study has great potential for
      industrial application such as catalyst support and adsorbent.

PMID- 29843410
TI  - Theoretical Study of Aluminum Hydroxide as a Hydrogen-Bonded Layered Material.
AB  - In many layer-structured materials, constituent layers are bound through van der
      Waals (vdW) interactions. However, hydrogen bonding is another type of weak
      interaction which can contribute to the formation of multi-layered materials. In
      this work, we investigate aluminum hydroxide [Al(OH) 3 ] having hydrogen bonding
      as an interlayer binding mechanism. We study the crystal structures and
      electronic band structures of bulk, single-layer, and multi-layer Al(OH) 3 using
      density functional theory calculations. We find that hydrogen bonds across the
      constituent layers indeed give rise to interlayer binding stronger than vdW
      interactions, and a reduction of the band gap occurs for an isolated layer as
      compared to bulk Al(OH) 3 which is attributed to the emergence of surface states.
      We also consider the alkali-halide intercalation between layers and examine how
      the intercalated atoms affect the atomic and electronic structures of Al(OH) 3 .

PMID- 29843411
TI  - Special Issue "Decision Models in Green Growth and Sustainable Development".

PMID- 29843412
TI  - Food Modulation Controls Astaxanthin Accumulation in Eggs of the Sea Urchin
      Arbacia lixula.
AB  - The carotenoid astaxanthin has strong antioxidant properties with beneficial
      effects for various degenerative diseases. This carotenoid is produced by some
      microalgae species when cultivated in particular conditions, and, interestingly,
      it is a predominant carotenoid in aquatic animals throughout a broad range of
      taxa. Recently, astaxanthin was detected in the eggs of the sea urchin Arbacia
      lixula in relevant concentrations when this organism was maintained in culture.
      These results have paved the way for deeper research into astaxanthin production
      by this species, particularly in regards to how astaxanthin production can be
      modulated by diet. Results showed that the highest content of astaxanthin in eggs
      was observed in sea urchins fed on a diet enriched with Spirulina platensis. This
      result was confirmed by the high antioxidant activity recorded in the egg
      extracts of these animals. Our results suggest that (i) the sea urchin A. lixula
      is able to synthesize astaxanthin from precursors obtained from food, and (ii) it
      is possible to modulate the astaxanthin accumulation in sea urchin eggs by
      modifying the proportions of different food ingredients provided in their diet.
      This study demonstrates the large potential of sea urchin cultivation for the eco
      sustainable production of healthy supplements for nutraceutical applications.

PMID- 29843413
TI  - Detection of Hemiplegic Walking Using a Wearable Inertia Sensing Device.
AB  - Hemiplegia is a symptom that is caused by reduced sensory and motor ability on
      one side of the body due to stroke-related neural defects. Muscular weakness and
      abnormal sensation that is induced by hemiplegia usually lead to motor
      impairments, such as difficulty in controlling the trunk, unstable balance, and
      poor walking ability. Therefore, most hemiplegia patients show defective and
      asymmetric gait pattern. The purpose of this study is to distinguish hemiplegic
      gait by extracting simple characteristics of acceleration signals that are caused
      by asymmetry during walking using a wearable system. The devised wearable system
      was equipped with a three-axis accelerometer and a three-axis gyroscope. We
      selected 165 candidate features without step detection. A random forest algorithm
      was used for the classification, and the forward search algorithm was also used
      for optimal feature selection. The developed system and algorithms were verified
      clinically in 15 normal subjects and 20 hemiplegia patients that were undergoing
      stroke treatment, and 26 subject's data was used for training, including
      validation, and nine subject's data used for test. As a result of test set, the
      accuracy, sensitivity, specificity and positive predictive value were 100.0%,
      with the two classification attributes of standard deviation of points
      perpendicular to the axis of line of identity of Poincare plot of angular
      velocity around vertical axis and kurtosis of frequency of angular velocity
      around longitudinal axis.

PMID- 29843414
TI  - Estimation of Temporal Gait Parameters Using a Human Body Electrostatic Sensing
      Based Method.
AB  - Accurate estimation of gait parameters is essential for obtaining quantitative
      information on motor deficits in Parkinson's disease and other neurodegenerative
      diseases, which helps determine disease progression and therapeutic
      interventions. Due to the demand for high accuracy, unobtrusive measurement
      methods such as optical motion capture systems, foot pressure plates, and other
      systems have been commonly used in clinical environments. However, the high cost
      of existing lab-based methods greatly hinders their wider usage, especially in
      developing countries. In this study, we present a low-cost, noncontact, and an
      accurate temporal gait parameters estimation method by sensing and analyzing the
      electrostatic field generated from human foot stepping. The proposed method
      achieved an average 97% accuracy on gait phase detection and was further
      validated by comparison to the foot pressure system in 10 healthy subjects. Two
      results were compared using the Pearson coefficient r and obtained an excellent
      consistency (r = 0.99, p < 0.05). The repeatability of the purposed method was
      calculated between days by intraclass correlation coefficients (ICC), and showed
      good test-retest reliability (ICC = 0.87, p < 0.01). The proposed method could be
      an affordable and accurate tool to measure temporal gait parameters in hospital
      laboratories and in patients' home environments.

PMID- 29843415
TI  - Drivers Are More Physically Active Than Non-Drivers in Older Adults.
AB  - Car use has been identified as sedentary behavior, although it may enhance
      mobility, particularly in the older population. This cross-sectional study aimed
      to compare the time spent in objectively determined sedentary behavior (SB) and
      physical activity (PA) between older drivers and non-drivers. Four hundred and
      fifty Japanese older adults (74.3 +/- 2.9 years) who had valid accelerometer data
      were included. They were asked to respond to a questionnaire and wear an
      accelerometer (HJA-350IT, Omron Healthcare) on their waist for 7 consecutive days
      in 2015. To compare activity time between drivers and non-drivers, we calculated
      estimated means using analysis of covariance, adjusting for sociodemographic,
      physical, and psychological factors and accelerometer wear time. Compared to non
      drivers, drivers engaged in more light-intensity PA (LPA) (drivers: 325.0 vs. non
      drivers: 289.0 min/day) and moderate-to-vigorous PA (drivers: 37.5 vs. non
      drivers: 30.0 min/day) and less SB (drivers: 493.4 vs. non-drivers: 535.9
      min/day) (all p < 0.05). After stratification by age, sex, and residential area,
      larger effect of driving on PA time was found in older-older adults, in men, and
      in rural residents. Older drivers were found to be more physically active than
      non-drivers, suggesting more access to outdoor activities or expanding social
      network.

PMID- 29843416
TI  - Identifying Degenerative Brain Disease Using Rough Set Classifier Based on
      Wavelet Packet Method.
AB  - Population aging has become a worldwide phenomenon, which causes many serious
      problems. The medical issues related to degenerative brain disease have gradually
      become a concern. Magnetic Resonance Imaging is one of the most advanced methods
      for medical imaging and is especially suitable for brain scans. From the
      literature, although the automatic segmentation method is less laborious and time
      consuming, it is restricted in several specific types of images. In addition,
      hybrid techniques segmentation improves the shortcomings of the single
      segmentation method. Therefore, this study proposed a hybrid segmentation
      combined with rough set classifier and wavelet packet method to identify
      degenerative brain disease. The proposed method is a three-stage image process
      method to enhance accuracy of brain disease classification. In the first stage,
      this study used the proposed hybrid segmentation algorithms to segment the brain
      ROI (region of interest). In the second stage, wavelet packet was used to conduct
      the image decomposition and calculate the feature values. In the final stage, the
      rough set classifier was utilized to identify the degenerative brain disease. In
      verification and comparison, two experiments were employed to verify the
      effectiveness of the proposed method and compare with the TV-seg (total variation
      segmentation) algorithm, Discrete Cosine Transform, and the listing classifiers.
      Overall, the results indicated that the proposed method outperforms the listing
      methods.

PMID- 29843417
TI  - The Preparation, Characterization and Formation Mechanism of a Calcium Phosphate
      Conversion Coating on Magnesium Alloy AZ91D.
AB  - The poor corrosion resistance of magnesium alloys is one of the main obstacles
      preventing their widespread usage. Due to the advantages of lower cost and
      simplicity in operation, chemical conversion coating has drawn considerable
      attention for its improvement of the corrosion resistance of magnesium alloys. In
      this study, a calcium phosphate coating was prepared on magnesium alloy AZ91D by
      chemical conversion. For the calcium phosphate coating, the effect of processing
      parameters on the microstructure and corrosion resistance was studied by scanning
      electron microscope (SEM) and electrochemical methods, and the coating
      composition was characterized by X-ray diffraction (XRD). The calcium phosphate
      coating was mainly composed of CaHPO4.2H2O (DCPD), with fewer cracks and pores.
      The coating with the leaf-like microstructure provided great corrosion resistance
      to the AZ91D substrate, and was obtained under the following conditions: 20 min,
      ambient temperature, and no stirring. At the same time, the role of NH4H2PO4 as
      the coating-forming agent and the acidifying agent in the conversion process was
      realized, and the formation mechanism of DCPD was discussed in detail in this
      work.

PMID- 29843418
TI  - Planetary Gear Fault Diagnosis via Feature Image Extraction Based on Multi
      Central Frequencies and Vibration Signal Frequency Spectrum.
AB  - Poor working environment leads to frequent failures of planetary gear trains.
      However, complex structure and variable transmission make the vibration signal
      strongly non-linear and non-stationary, which brings big problems to fault
      diagnosis. A method of planetary gear fault diagnosis via feature image
      extraction based on multi central frequencies and vibration signal frequency
      spectrum is proposed. The original vibration signal is decomposed by variational
      mode decomposition (VMD), and four components with narrow bands and independent
      central frequencies are decomposed. In order to retain the feature spectrum of
      the original vibration signal as far as possible, the corresponding feature bands
      are intercepted from the frequency spectrum of original vibration signal based on
      the central frequency of each component. Then, the feature images of fault
      signals are constructed as the inputs of the convolution neural network (CNN),
      and the parameters of the neural network are optimized by sample training.
      Finally, the optimized CNN is used to identify fault signals. The overall fault
      recognition rate is up to 98.75%. Compared with the feature bands extracted
      directly from the component spectrums, the extraction method of the feature bands
      proposed in this paper needs fewer iterations under the same network structure.
      The method of planetary gear fault diagnosis proposed in this paper is effective.

PMID- 29843419
TI  - Standard Polymeric Formula Tube Feeding in Neurologically Impaired Children: A
      Five-Year Retrospective Study.
AB  - Malnutrition is frequent in neurologically impaired (NI) children. Enteral
      feeding via gastrostomy tube is increasingly being used to provide adequate
      nutrition. Our aim was to assess the outcomes of exclusive gastrostomy tube
      feeding with standard polymeric formula in children with NI, severe oro-motor
      dysfunction, and malnutrition, and to investigate the role of the underlying NI
      associated disease. A five-year retrospective study from January 2013 to November
      2017 was conducted. The primary aim was to assess the nutritional outcomes of
      exclusive gastrostomy tube feeding with standard polymeric formula in
      malnourished NI children. The secondary aim was to investigate gastrostomy
      complications and the impact of the underlying NI-associated disease on the
      nutritional outcomes. We enrolled 110 consecutive children with NI. Of these
      patients, 34.5% (N = 38) were categorized as malnourished and started exclusive
      enteral feeding with a standard (1.0 kcal/mL) polymeric formula (Nutrini,
      Nutricia) after percutaneous endoscopic gastrostomy (PEG) placement. Seventy
      three percent of patients (N = 28) had cerebral palsy (CP); other diagnoses
      included metabolic (13%, N = 5) and genetic (13%, N = 5) diseases. Tricep
      skinfold thickness had significantly improved in all patients at 12-months follow
      up, while body weight and body mass index showed significant increases mainly in
      children with CP. No serious complications occurred. We found that standard
      polymeric formula via gastrostomy tube represents a safe and efficient
      nutritional intervention in children with NI and malnutrition.

PMID- 29843420
TI  - Incobotulinumtoxin A for Sialorrhea in Neurological Disorders: A Real-Life
      Experience.
AB  - Botulinum toxin type A is one of the most useful treatments of sialorrhea in
      neurological disorders. Evidence for the use of incobotulinumtoxin A (inco-A) in
      the treatment of sialorrhea is limited. Thirty-six patients with sialorrhea were
      treated with infiltrations of inco-A into both parotid glands. The severity of
      sialorrhea was evaluated by the Drooling Severity Scale (DSS), and the Drooling
      Frequency Scale (DFS). Patients' perceptions of clinical benefit were recorded
      via the Patient Global Impression of Improvement (PGI-I) scale. Following
      treatment, there was a significant difference in both the DFS and the DSS (p <
      0.001). Clinical benefits on the basis of the PGI-I were present in up to 90% of
      patients.

PMID- 29843421
TI  - Effect of Cardiac Rehabilitation on Quality of Life, Depression and Anxiety in
      Asian Patients.
AB  - This study explored the effect of cardiac rehabilitation on quality of life,
      depression, and anxiety in Asian patients in Singapore. Out of the 194 patients
      who were recruited into the study, 139 patients (71.6%) completed both the pre-
      and post-cardiac rehabilitation questionnaires. Their ages ranged from 28 to 80
      (M = 56.66, SD = 8.88), and 103 patients (74.1%) were males and 21 patients
      (15.1%) were females. As hypothesized, there was a statistically significant
      difference between the pre- and post-cardiac rehabilitation scores on the
      combined dependent variables, F (4, 135) = 34.84, p < 0.001; Wilks' Lambda =
      0.49; partial eta squared = 0.51. An inspection of the mean scores indicated that
      patients reported higher levels of physical and mental quality of life and lower
      levels of depression post-cardiac rehabilitation. The findings were discussed in
      regards to implications in cardiac rehabilitation in Singapore.

PMID- 29843422
TI  - Characterization of Magnesium Silicate Hydrate (MSH) Gel Formed by Reacting MgO
      and Silica Fume.
AB  - Magnesium silicate hydrate (MSH) gel was formed by reacting magnesium oxide (MgO)
      with silica fume (SF) in distilled water. The MSH was prepared using a MgO/SF
      molar ratio of 1.0 (40:60 weight ratio). Samples were analyzed during hydration
      process up to 300 days at room temperature. The MSH characterization has been
      carried out using a range of analytical techniques. Quantitative analysis was
      achieved using thermogravimetric analysis (TG/DTG) with a de-convolution
      technology. The structure of MSH gel was characterized using solid state nuclear
      magnetic resonance (29Si NMR) and Fourier transform infrared (FT-IR)
      spectroscopy. Transmission electron microscopy (TEM) was used to investigate MSH
      microstructure. Compared with natural magnesium silicate hydrate minerals, the
      structure of MSH gel is highly disordered and generates on the surface of
      particles, producing a shell structure with cavity. The molecular structure of
      MSH phase is layered. The results also show that the extent of polymerization of
      MSH gel is related to the solution pH during hydration.

PMID- 29843423
TI  - Obstacles and Future Prospects: Considerations on Health Promotion Activities for
      Older Workers in Europe.
AB  - The ageing of workers is one of the most important issues for occupational health
      and safety in Europe. The ageing of the active population means that health
      promotion is a necessity rather than a mere option. This review considers
      barriers and perspectives for workplace health promotion for older workers. Lack
      of awareness on the part of management and inflexibility in the occupational
      health and safety system appear to be major barriers. To overcome these, it will
      be necessary to disseminate knowledge regarding the effectiveness of health
      promotion actions for older workers, encourage greater involvement on the part of
      social partners, recover resources by replacing medical consumerism and
      bureaucratic practices, adopt an integrated approach combining the prevention of
      occupational risks and the promotion of healthy lifestyles, and recognize
      subsidiarity and the ability of working communities to regulate themselves.

PMID- 29843424
TI  - Red to Far-Red Light Ratio Modulates Hormonal and Genetic Control of Axillary bud
      Outgrowth in Chrysanthemum (Dendranthema grandiflorum 'Jinba').
AB  - Single-flower cut Chrysanthemum (Dendranthema grandiflorum 'Jinba') holds a
      unique status in global floriculture industry. However, the extensive axillary
      bud outgrowth presents a major drawback. Shade is an environment cue that
      inhibits shoot branching. Present study was aimed at investigating the effect of
      ratio of red to far-red light (R:FR) in regulating the lateral bud outgrowth of
      Chrysanthemum and the detailed mechanism. Results showed that the fate of
      axillary buds at specific positions in stem exhibited difference in response to
      R:FR. Decreasing R:FR resulted in elevation of abscisic acid (ABA) accumulation
      in axillary buds. Expression of ABA, indole-3-acetic acid (IAA) and
      strigolactones (SL) -related metabolism and signal transduction genes was
      significantly changed in response to low R:FR. In addition, low R:FR caused the
      re-distribution of sucrose across the whole plant, driving more sucrose towards
      bottom buds. Our results indicate that low R:FR not always inhibits bud
      outgrowth, rather its influence depends on the bud position in the stem. ABA, SL
      and auxin pathways were involved in the process. Interestingly, sucrose also
      appears to be involved in the process which is necessary to pay attention in the
      further studies. The present study also lays the foundation for developing
      methods to regulate axillary bud outgrowth in Chrysanthemum.

PMID- 29843426
TI  - Neuromodulatory Treatments for Alcohol Use Disorder: A Review.
AB  - Alcohol use disorder (AUD) is a prevalent condition characterized by chronic
      alcohol-seeking behaviors and has become a significant economic burden with
      global ramifications on public health. While numerous treatment options are
      available for AUD, many are unable to sustain long-term sobriety. The nucleus
      accumbens (NAcc) upholds an integral role in mediating reward behavior and has
      been implicated as a potential target for deep brain stimulation (DBS) in the
      context of AUD. DBS is empirically thought to disrupt pathological neuronal
      synchrony, a hallmark of binge behavior. Pre-clinical animal models and pilot
      human clinical studies utilizing DBS for the treatment of AUD have shown promise
      for reducing alcohol-related cravings and prolonging abstinence. In this review,
      we outline the various interventions available for AUD, and the translational
      potential DBS has to modulate functionality of the NAcc as a treatment for AUD.

PMID- 29843427
TI  - One-Step Synthesis of Au-Ag Nanowires through Microorganism-Mediated, CTAB
      Directed Approach.
AB  - Synthesis and applications of one dimensional (1D) metal nanostructures have
      attracted much attention. However, one-step synthesis of bimetallic nanowires
      (NWs) has remained challenging. In this work, we developed a microorganism
      mediated, hexadecyltrimethylammonium bromide (CTAB)-directed (MCD) approach to
      synthesize closely packed and long Au-Ag NWs with the assistance of a continuous
      injection pump. Characterization results confirmed that the branched Au-Ag alloy
      NWs was polycrystalline. And the Au-Ag NWs exhibited a strong absorbance at
      around 1950 nm in the near-infrared (NIR) region, which can find potential
      application in NIR absorption. In addition, the Au-Ag NWs showed excellent
      surface-enhanced Raman scattering (SERS) enhancement when 4-mercaptobenzoic acid
      (MBA) and rhodamine 6G (R6G) were used as probe molecules.

PMID- 29843428
TI  - Small Intestinal Permeability and Gut-Transit Time Determined with Low and High
      Molecular Weight Fluorescein Isothiocyanate-Dextrans in C3H Mice.
AB  - Protocols for intestinal permeability measurements in mice using 4-kDa
      fluorescein isothiocyanate-conjugated (FITC) dextran differ considerably among
      laboratories on the blood-sampling time. To find the optimal point in time for
      blood sampling, we administered 4-kDa FITC dextran to C3H mice and monitored the
      marker in plasma over 8 h. We also determined gut-transit time using 70-kDa FITC
      dextran, which does not cross the intestinal epithelium. The 4-kDa FITC dextran
      concentration in plasma reached its maximum 45 min after administration. The 70
      kDa FITC dextran reached the jejunum after 15 min and passed the entire small
      intestine within 1 h after its administration, demonstrating that 4-kDa FITC
      dextran measured in plasma 1 h after its oral application is a marker of small
      intestinal permeability.

PMID- 29843425
TI  - Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition.
AB  - Epithelial-to-mesenchymal transition (EMT) is a key biological process involved
      in a multitude of developmental and pathological events. It is characterized by
      the progressive loss of cell-to-cell contacts and actin cytoskeletal
      rearrangements, leading to filopodia formation and the progressive up-regulation
      of a mesenchymal gene expression pattern enabling cell migration. Epithelial-to
      mesenchymal transition is already observed in early embryonic stages such as
      gastrulation, when the epiblast undergoes an EMT process and therefore leads to
      the formation of the third embryonic layer, the mesoderm. Epithelial-to
      mesenchymal transition is pivotal in multiple embryonic processes, such as for
      example during cardiovascular system development, as valve primordia are formed
      and the cardiac jelly is progressively invaded by endocardium-derived mesenchyme
      or as the external cardiac cell layer is established, i.e., the epicardium and
      cells detached migrate into the embryonic myocardial to form the cardiac fibrous
      skeleton and the coronary vasculature. Strikingly, the most important biological
      event in which EMT is pivotal is cancer development and metastasis. Over the last
      years, understanding of the transcriptional regulatory networks involved in EMT
      has greatly advanced. Several transcriptional factors such as Snail, Slug, Twist,
      Zeb1 and Zeb2 have been reported to play fundamental roles in EMT, leading in
      most cases to transcriptional repression of cell-cell interacting proteins such
      as ZO-1 and cadherins and activation of cytoskeletal markers such as vimentin. In
      recent years, a fundamental role for non-coding RNAs, particularly microRNAs and
      more recently long non-coding RNAs, has been identified in normal tissue
      development and homeostasis as well as in several oncogenic processes. In this
      study, we will provide a state-of-the-art review of the functional roles of non
      coding RNAs, particularly microRNAs, in epithelial-to-mesenchymal transition in
      both developmental and pathological EMT.

PMID- 29843429
TI  - A Study on Photostability of Amphetamines and Ketamine in Hair Irradiated under
      Artificial Sunlight.
AB  - Drugs incorporated into hair are exposed to the environment, and cosmetic and
      chemical treatments, with possible decreases in their content. Knowledge
      concerning the effect of sunlight on drug content in hair can be helpful to
      forensic toxicologists, in particular, when investigating drug concentrations
      above or below pre-determined cut-offs. Twenty authentic positive hair samples
      were selected which had previously tested positive for amphetamines and/or
      ketamine. Washed hair were divided into two identical strands, with the former
      exposed at 765 W/m2 (300-800 nm spectrum of irradiance) for 48 h in a solar
      simulator, and the latter kept in the dark. Hair samples were extracted and
      analyzed by liquid chromatography high-resolution mass spectrometry detection.
      The percentage of photodegradation was calculated for each analyte (i.e.,
      amphetamine, methamphetamine, methylendioxyamphetamine, ketamine, and
      norketamine). In parallel, photodegradation processes of standard molecules
      dissolved in aqueous and organic solutions were studied. In 20 hair samples
      positive for the targeted analytes, exposure to artificial sunlight induced an
      appreciable decrease in drug concentrations. The concentration ranges in the non
      irradiated hair samples were 0.01-24 ng/mg, and 65% of samples exhibited a
      decrease in post-irradiation samples, with reduction from 3% to 100%. When more
      drugs were present in the same hair sample (i.e., MDMA and ketamine) the
      degradation yields were compound dependent. A degradation product induced by
      irradiation of ketamine in aqueous and methanol solutions was identified; it was
      also found to be present in a true positive hair sample after irradiation.
      Ketamine, amphetamines, and their metabolites incorporated in the hair of drug
      users undergo degradation when irradiated by artificial sunlight. Only for
      ketamine was a photoproduct identified in irradiated standard solutions and in
      true positive irradiated hair. When decisional cut-offs are applied to hair
      analysis, photodegradation must be taken into account since sunlight may produce
      false negative results. Moreover, new markers could be investigated as evidence
      of illicit drug use.

PMID- 29843430
TI  - ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 4: From
      Discovery to Cure: The Future of Therapeutics.
AB  - The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by
      the European Union Horizon 2020 program involving four renowned European Research
      Institutes (Institute for Research in Biomedicine-IRB Barcelona, Spain; Radboud
      Institute for Molecular Life Sciences-RIMLS, the Netherlands; Novo Nordisk
      Foundation Center for Protein Research-NNF CPR, Denmark; European School of
      Molecular Medicine-SEMM, Italy) and an innovative science communication agency
      (Scienseed). With the aim of promoting biomedical science of excellence in
      Europe, ENABLE organizes an annual three-day international event. This gathering
      includes a top-level scientific symposium bringing together leading scientists,
      PhD students, and post-doctoral fellows; career development activities supporting
      the progression of young researchers and fostering discussion about opportunities
      beyond the bench; and outreach activities stimulating the interaction between
      science and society. The first European PhD and Postdoc Symposium, entitled
      "Breaking Down Complexity: Innovative Models and Techniques in Biomedicine", was
      hosted by the vibrant city of Barcelona. The scientific program of the conference
      was focused on the most recent advances and applications of modern techniques and
      models in biomedical research and covered a wide range of topics, from synthetic
      biology to translational medicine. Overall, the event was a great success, with
      more than 200 attendees from all over Europe actively participating in the
      symposium by presenting their research and exchanging ideas with their peers and
      world-renowned scientists.

PMID- 29843432
TI  - Facile Synthesis of Porous ZnCo2O4 Nanosheets and the Superior Electrochemical
      Properties for Sodium Ion Batteries.
AB  - ZnCo2O4 nanosheets with large surface area and mesoporous structure were
      synthesized using a facile hydrothermal method followed with a calcination
      process. When applied as the anode material in sodium ion batteries, the ZnCo2O4
      nanosheets demonstrated a high initial charge capacity of 415.1 mAh/g at the
      current density of 100 mA/g. Even though the reversible capacity decreased in the
      first 20 cycles, it stayed relatively stable afterwards and retained 330 mAh/g
      after 100 cycles. This result was superior to those of many reported works of ZnO
      and Co3O4-based anodes for sodium ion batteries, which might be due to the
      synergistic effect of both Zn and Co, and the refined porous nanosheet-like
      structure which facilitates electrochemical reactions by providing more reaction
      sites and ensures cycling stability by providing more space to accommodate the
      structural strains during cycles.

PMID- 29843431
TI  - Multifunctionalized Reduced Graphene Oxide Biosensors for Simultaneous Monitoring
      of Structural Changes in Amyloid-beta 40.
AB  - Determination of the conformation (monomer, oligomer, or fibril) of amyloid
      peptide aggregates in the human brain is essential for the diagnosis and
      treatment of Alzheimer's disease (AD). Accordingly, systematic investigation of
      amyloid conformation using analytical tools is essential for precisely
      quantifying the relative amounts of the three conformations of amyloid peptide.
      Here, we developed a reduced graphene oxide (rGO) based multiplexing biosensor
      that could be used to monitor the relative amounts of the three conformations of
      various amyloid-beta 40 (Abeta40) fluids. The electrical rGO biosensor was
      composed of a multichannel sensor array capable of individual detection of
      monomers, oligomers, and fibrils in a single amyloid fluid sample. From the
      performance test of each sensor, we showed that this method had good analytical
      sensitivity (1 pg/mL) and a fairly wide dynamic range (1 pg/mL to 10 ng/mL) for
      each conformation of Abeta40. To verify whether the rGO biosensor could be used
      to evaluate the relative amounts of the three conformations, various amyloid
      solutions (monomeric Abeta40, aggregated Abeta40, and disaggregated Abeta40
      solutions) were employed. Notably, different trends in the relative amounts of
      the three conformations were observed in each amyloid solution, indicating that
      this information could serve as an important parameter in the clinical setting.
      Accordingly, our analytical tool could precisely detect the relative amounts of
      the three conformations of Abeta40 and may have potential applications as a
      diagnostic system for AD.

PMID- 29843435
TI  - An Unambiguous Delay-And-Multiply Acquisition Scheme for GPS L1C Signals.
AB  - The GPS provides positioning information almost anytime and anywhere on Earth,
      regardless of the weather conditions, and has become an essential technology for
      positioning and navigation. As a modernization program, the fourth civil GPS
      signal, denoted as L1C, will be transmitted from Block III satellites. One
      distinction of the L1C signal from the former signals is the use of binary offset
      carrier (BOC) modulation, which is necessary for compatibility and the reduction
      of interference between the legacy L1 signal and L1C signal, despite their use of
      the same carrier frequency. One drawback of using BOC modulation is the ambiguity
      problem, which comes from the multiple peaks in the correlation function and
      causes difficulties finding the code phase in the acquisition process. In this
      paper we suggest two delay-and-multiply (DM) methods for the L1C signal to solve
      the ambiguity problem. For the DM acquisition schemes we suggest the optimal
      delay time for the delay signal, and prove that the correlation function of the
      received DM signal and the generated DM signal has a triangular shape, as seen in
      the legacy GPS L1 signal. The noise characteristics of the decision variable are
      obtained and the performance of the DM acquisition scheme is given in terms of
      the probability of detection, and compared with that of the conventional method.
      We provide the procedure to find the Doppler frequency after obtaining the code
      phase through the proposed DM method.

PMID- 29843433
TI  - Stress Response and Cognitive Performance Modulation in Classroom versus Natural
      Environments: A Quasi-Experimental Pilot Study with Children.
AB  - Stress during childhood can have mental and somatic health influences that track
      throughout life. Previous research attributes stress-reducing effects to natural
      environments, but has mainly focused on adults and often following leisurely
      relaxation in natural environments. This pilot study explores the impact of
      natural environments on stress response during rest and mental load and cognitive
      performance in 47 children aged 10-12 years in a school context. Heart rate
      variability measures indexing tonic, event, and phasic vagal tone and attention
      scores were compared across classroom and natural environments. Tonic vagal tone
      was higher in the natural environment than the classrooms, but no differences
      were found in event or phasic vagal tone or cognitive performance measures. These
      findings suggest a situational aspect of the conditions under which natural
      environments may give rise to stress-buffering influences. Further research is
      warranted to understand the potential benefits in a real-life context, in
      particular with respect to the underpinning mechanisms and effects of accumulated
      exposure over time in settings where children spend large proportions of time in
      natural environments.

PMID- 29843434
TI  - Project SoL-A Community-Based, Multi-Component Health Promotion Intervention to
      Improve Eating Habits and Physical Activity among Danish Families with Young
      Children. Part 1: Intervention Development and Implementation.
AB  - Project SoL was implemented over a period of four years from 2012-2015 with the
      aim to promote healthy eating and physical activity among families with children
      aged 3-8 years, living in selected communities in two Danish municipalities. This
      was done by applying the supersetting approach to implement complex multi
      component interventions in a participatory, coordinated, and integrated manner in
      childcare centres, schools, and supermarkets in three local communities, as well
      as in local media during a 19-month period in the Regional Municipality of
      Bornholm, which served as the intervention site. The matching municipality of
      Odsherred served as a control site based on its similarity to Bornholm regarding
      several socio-demographic and health indicators. The present paper describes the
      design of Project SoL as well as the processes of developing and implementing its
      complex interventions. Moreover, the theoretical and conceptual framework of the
      project is described together with its organisational structure, concrete
      activities, and sustainability measures. The paper discusses some of the key
      lessons learned related to participatory development and the implementation of a
      multi-component intervention. The paper concludes that coordinated and integrated
      health promotion activities that are implemented together with multiple
      stakeholders and across multiple settings in the local community are much more
      powerful than individual activities carried out in single settings. The
      supersetting approach was a useful conceptual framework for developing and
      implementing a complex multi-component health promotion intervention and for
      fostering ownership and sustainability of the intervention in the local
      community. The research and evaluation approach of the project is described in a
      separate paper (Part 2).

PMID- 29843436
TI  - Research on a Novel MEMS Sensor for Spatial DC Electric Field Measurements in an
      Ion Flows Field.
AB  - Thus far, despite the development of electric field sensors (EFSs) such as field
      mills, optoelectronic EFSs and microelectromechanical system (MEMS)-based EFSs,
      no sensor can accurately measure an electric field in space due to the existence
      of space charge and the influence of charge attachment. To measure a spatial
      synthetic electric field in an ion flow field, a double potential independent
      differential EFS based on MEMS is proposed. Compared with other EFSs, this method
      has the advantages of independent potential (without grounding) and the ability
      to support the measurement of the synthetic ion flow electric field in space.
      First, to analyse the charge distribution after the sensor is involved exposed to
      an electric field, a simulation model was constructed. Then, given the
      redistribution of the spatial electric field in space and the influence of the
      surface charge on the sensor, the quantitative relationship between the electric
      field to be measured and that measured by the proposed sensor was obtained. To
      improve the performance of the EFS, a set of synthetic field strength sensor
      calibration systems that consider spatial ion flow injection was established.
      Furthermore, the parameter lambda, which is related to the relative position of
      the differential chips, was determined. Finally, a series of comparative
      experiments indicated that the differential EFS highlighted in the present study
      exhibits good linearity and accuracy.

PMID- 29843437
TI  - Expectation-Maximization Model for Substitution of Missing Values Characterizing
      Greenness of Organic Solvents.
AB  - Organic solvents are ubiquitous in chemical laboratories and the Green Chemistry
      trend forces their detailed assessments in terms of greenness. Unfortunately,
      some of them are not fully characterized, especially in terms of toxicological
      endpoints that are time consuming and expensive to be determined. Missing values
      in the datasets are serious obstacles, as they prevent the full greenness
      characterization of chemicals. A featured method to deal with this problem is the
      application of Expectation-Maximization algorithm. In this study, the dataset
      consists of 155 solvents that are characterized by 13 variables is treated with
      Expectation-Maximization algorithm to predict missing data for toxicological
      endpoints, bioavailability, and biodegradability data. The approach may be
      particularly useful for substitution of missing values of environmental, health,
      and safety parameters of new solvents. The presented approach has high potential
      to deal with missing values, while assessing environmental, health, and safety
      parameters of other chemicals.

PMID- 29843438
TI  - Two-Dimensional Direction-of-Arrival Fast Estimation of Multiple Signals with
      Matrix Completion Theory in Coprime Planar Array.
AB  - In estimating the two-dimensional (2D) direction-of-arrival (DOA) using a coprime
      planar array, the main issues are the high complexity of spectral peak search and
      the limited degree of freedom imposed by the number of sensors. In this paper, we
      present an algorithm based on the matrix completion theory in coprime planar
      array that reduces the computational complexity and obtains a high degree of
      freedom. The algorithm first analyzes the covariance matrix of received signals
      to estimate the covariance matrix of a virtual uniform rectangular array, which
      has the same aperture as the coprime planar array. Matrix completion theory is
      then applied to estimate the missing elements of the virtual array covariance
      matrix. Finally, a closed-form DOA solution is obtained using the unitary
      estimation signal parameters via rotational invariance techniques (Unitary
      ESPRIT). Simulation results show that the proposed algorithm has a high degree of
      freedom, enabling the estimation of more signal DOAs than the number of sensors.
      The proposed algorithm has reduced computational complexity because the spectral
      peak search is replaced by Unitary-ESPRIT, but attains similarly high levels
      accuracy to those of the 2D multiple signal classification algorithm.

PMID- 29843439
TI  - Gender and Sexual Orientation Differences in Human Papillomavirus (HPV) Vaccine
      Uptake among Chinese Young Adults.
AB  - To date, empirical studies on HPV vaccine uptake are still limited in Chinese
      populations and mainly conducted in female cohorts. In order to inform health
      services planning and health promotion programmes for HPV vaccination, this cross
      sectional study aimed to report the prevalence of self-reported HPV vaccination
      status and to examine gender and sexual orientation differences in the uptake of
      HPV vaccine in Chinese college students. The overall prevalence of HPV vaccine
      uptake was 27.6% (n = 242), with a significantly higher prevalence in females
      (39.7%) than in males (4.7%). 91.4% of subjects heard about HPV vaccination, with
      a significantly higher prevalence in females (93.8%) than in males (86.8%). The
      prevalence of HPV vaccine uptake was only 2.6% for bisexual/ homosexual males and
      5.0% for heterosexual males. Only 45.8% of the overall subjects knew HPV
      vaccination is not for females only, with a significantly higher prevalence in
      females (49.7%) than in males (38.6%). The low prevalence of male HPV vaccine
      uptake and awareness called for the need to have more male-specific HPV campaigns
      to promote HPV vaccination awareness and uptake in males to reduce the overall
      prevalence of HPV infection.

PMID- 29843440
TI  - Effect of Fucoidan on Anterior Cruciate Ligament Transection and Medial
      Meniscectomy Induced Osteoarthritis in High-Fat Diet-Induced Obese Rats.
AB  - Osteoarthritis (OA) has become one of the most common disabilities among elders,
      especially in females. Obesity and mechanical injuries caused by OA are
      attributed to joint loading, cartilage disintegration, and bone loss, as well as
      inflammation. Pharmacological and non-pharmacological treatments can be used for
      OA. Fucoidan possesses several bioactivities such as antitumor, antiviral,
      anticoagulation, anti-obesity, and immunomodulation. This study aims to
      investigate the effect of fucoidan in surgery-induced OA on rats with diet
      induced obesity. OA was induced by an anterior cruciate ligament transection and
      a partial medial meniscectomy (ACLT + MMx). The male SD rats were fed with a high
      fat diet (HFD) for 4 weeks to induce obesity before causing ACLT + MMx to induce
      OA. The OA rats were administered with intragastric water or fucoidan in three
      different concentrations (32 mg/kg, 64 mg/kg, and 320 mg/kg) after the surgeries
      for 40 days with an HFD. We observed that the swelling in the knee joint was
      alleviated and the hind paw weight distribution was rectified after feeding them
      with fucoidan and that there was no significant effect on the weight gain and
      feed intake. Fucoidan administration indicated no significant variation on the
      high-density lipoprotein (HDL)-Cholesterol level, but it did indicate reduced
      plasma triglycerides and low-density lipoprotein (LDL)-Cholesterol levels. In
      addition, the weight-bearing tests showed an improvement in the fucoidan-treated
      group. Our results suggested that fucoidan may improve meniscal/ligamentous
      injury and obesity-induced OA.

PMID- 29843441
TI  - Electrodegradation of Resorcinol on Pure and Catalyst-Modified Ni Foam Anodes,
      Studied under Alkaline and Neutral pH Conditions.
AB  - This work reports on the kinetics of electrochemical degradation of the
      resorcinol molecule, examined on nickel foam-based electrodes in contact with 0.1
      M NaOH and 0.5 M Na2SO4 supporting electrolytes. The electrooxidation of
      resorcinol was examined on as-received, as well as on Pd-modified, nickel foam
      catalyst materials, produced via spontaneous deposition of trace amounts of
      palladium element. Electrochemical (cyclic voltammetry and a.c. impedance)
      experiments were carried out by means of a three-compartment, pyrex glass
      electrochemical cell, whereas continuous resorcinol electrooxidation tests were
      conducted galvanostatically (or potentistatically) with a laboratory-size, single
      cell electrolyzer unit. In addition, quantitative determination of resorcinol and
      its possible electrodegradation products was performed by means of instrumental
      HPLC: High-Performance Liquid Chromatography/MS: Mass Spectrometry methodology.
      Also, SEM (Scanning Electron Microscopy) and EDX (Energy Dispersive X-ray
      spectroscopy) techniques were employed for Ni foam (Pd-modified Ni foam) surface
      characterizations.

PMID- 29843442
TI  - Nonlinear Buckling Analysis of Functionally Graded Graphene Reinforced Composite
      Shallow Arches with Elastic Rotational Constraints under Uniform Radial Load.
AB  - The buckling behavior of functionally graded graphene platelet-reinforced
      composite (FG-GPLRC) shallow arches with elastic rotational constraints under
      uniform radial load is investigated in this paper. The nonlinear equilibrium
      equation of the FG-GPLRC shallow arch with elastic rotational constraints under
      uniform radial load is established using the Halpin-Tsai micromechanics model and
      the principle of virtual work, from which the critical buckling load of FG-GPLRC
      shallow arches with elastic rotational constraints can be obtained. This paper
      gives special attention to the effect of the GPL distribution pattern, weight
      fraction, geometric parameters, and the constraint stiffness on the buckling
      load. The numerical results show that all of the FG-GPLRC shallow arches with
      elastic rotational constraints have a higher buckling load-carrying capacity
      compared to the pure epoxy arch, and arches of the distribution pattern X have
      the highest buckling load among four distribution patterns. When the GPL weight
      fraction is constant, the thinner and larger GPL can provide the better
      reinforcing effect to the FG-GPLRC shallow arch. However, when the value of the
      aspect ratio is greater than 4, the flakiness ratio is greater than 103, and the
      effect of GPL's dimensions on the buckling load of the FG-GPLRC shallow arch is
      less significant. In addition, the buckling model of FG-GPLRC shallow arch with
      elastic rotational constraints is changed as the GPL distribution patterns or the
      constraint stiffness changes. It is expected that the method and the results that
      are presented in this paper will be useful as a reference for the stability
      design of this type of arch in the future.

PMID- 29843444
TI  - Multi-Target Risk Assessment of Potentially Toxic Elements in Farmland Soil Based
      on the Environment-Ecological-Health Effect.
AB  - There are potential impacts of Potentially Toxic Elements (PTEs) (e.g., Cd, Cr,
      Ni, Cu, As, Zn, Hg, and Pb) in soil from the perspective of the ecological
      environment and human health, and assessing the pollution and risk level of soil
      will play an important role in formulating policies for soil pollution control.
      Lingyuan, in the west of Liaoning Province, China, is a typical low-relief
      terrain of a hilly area. The object of study in this research is the topsoil of
      farmland in this area, of which 71 soil samples are collected. In this study,
      research methods, such as the Nemerow Index, Potential Ecological Hazard Index,
      Ecological Risk Quotient, Environmental Exposure Hazard Analysis, Positive Matrix
      Factorization Model, and Land Statistical Analysis, are used for systematical
      assessment of the pollution scale, pollution level, and source of PTEs, as well
      as the ecological environmental risks and health risks in the study area. The
      main conclusions are: The average contents of As, Cd, Cr, Cu, Hg, Zn, Ni, and Pb
      of the soil are 5.32 mg/kg, 0.31 mg/kg, 50.44 mg/kg, 47.05 mg/kg, 0.03 mg/kg,
      79.36 mg/kg, 26.01 mg/kg, and 35.65 mg/kg, respectively. The contents of Cd, Cu,
      Zn, and Pb exceed the background value of local soil; Cd content of some study
      plots exceeds the National Soil Environmental Quality Standard Value (0.6 mg/kg),
      and the exceeding standard rate of study plots is 5.63%; the comprehensive
      potential ecological hazard assessment in the study area indicates that the PTEs
      are at a slight ecological risk; probabilistic hazard quotient assessment
      indicates that the influence of PTEs on species caused by Cu is at a slight level
      (p = 10.93%), and Zn, Pb, and Cd are at an acceptable level. For the ecological
      process, Zn is at a medium level (p = 25.78%), Cu is at a slight level (19.77%),
      and the influence of Cd and Pb are acceptable; human health hazard assessment
      states that the Non-carcinogenic comprehensive health hazard index HI = 0.16 < 1,
      indicating that PTEs in soil have no significant effect on people's health
      through exposure; the PMF model (Positive Matrix Factorization) shows that the
      contribution rates of agricultural source, industrial source, atmospheric dust
      source, and natural source are 13.15%, 25.33%, 18.47%, and 43.05%, respectively.

PMID- 29843445
TI  - Time to Rethink Refugee and Migrant Health in Europe: Moving from Emergency
      Response to Integrated and Individualized Health Care Provision for Migrants and
      Refugees.
AB  - In the last three years, the European Union (EU) is being confronted with the
      most significant influx of migrants and refugees since World War II. Although the
      dimensions of this influx-taking the global scale into account-might be regarded
      as modest, the institutional response to that phenomenon so far has been
      suboptimal, including the health sector. While inherent challenges of refugee and
      migrant (R&M) health are well established, it seems that the EU health response
      oversees, to a large extend, these aspects. A whole range of emergency-driven
      health measures have been implemented throughout Europe, yet they are failing to
      address adequately the changing health needs and specific vulnerabilities of the
      target population. With the gradual containment of the migratory and refugee
      waves, three years after the outbreak of the so-called 'refugee crisis', we are,
      more than ever, in need of a sustainable and comprehensive health approach that
      is aimed at the integration of all of migrants and refugees-that is, both the new
      and old population groups that are already residing in Europe-in the respective
      national health systems.

PMID- 29843446
TI  - Reply to Comments: A Novel Low-Cost Instrumentation System for Measuring the
      Water Content and Apparent Electrical Conductivity of Soils, Sensors, 15, 25546
      25563.
AB  - In this article we respond to the comments made by Chavanne et al., who have
      questioned: (i) the name of the technique used; (ii) the ability of the system to
      determine both soil water content and salinity due to potential instrument biases
      and choice of sensor frequencies; and (iii) the procedure used to determine
      temperature effect on readings presented in the article "A Novel Low-Cost
      Instrumentation System for Measuring the Water Content and Apparent Electrical
      Conductivity of Soils" (Sensors 2015, 15, 25546-25563). We have carefully
      analyzed the arguments in the comment, and have concluded that they only
      partially affect the previous conclusions, as will be discussed in this reply. We
      show here that the findings and conclusions previously drawn are valid and
      supported by the many experiments previously conducted.

PMID- 29843443
TI  - Maternal Circulating Vitamin Status and Colostrum Vitamin Composition in Healthy
      Lactating Women-A Systematic Approach.
AB  - Colostrum is the first ingested sole nutritional source for the newborn infant.
      The vitamin profile of colostrum depends on the maternal vitamin status, which in
      turn is influenced by diet and lifestyle. Yet, the relationship between maternal
      vitamin status and colostrum vitamin composition has not been systematically
      reviewed. This review was conducted with the aim to generate a comprehensive
      overview on the relationship between maternal serum (plasma) vitamin
      concentration and corresponding colostrum composition. Three electronic
      databases, Embase (Ovid), Medline (Ovid), and Cochrane, were systematically
      searched based on predefined inclusion and exclusion criteria. Finally, a total
      of 11 eligible publications were included that examined the vitamins A, C, D, E,
      and K in both biological fluids. Maternal vitamin A, D, E, and K blood levels
      were unrelated to colostrum content of the respective vitamins, and serum vitamin
      A was inversely correlated with colostrum vitamin E. Colostrum versus maternal
      serum vitamins were higher for vitamins A, C, and K, lower for vitamin D, and
      divergent results were reported for vitamin E levels. Colostrum appears typically
      enriched in vitamin A, C, and K compared to maternal serum, possibly indicative
      of active mammary gland transport mechanisms. Inter-individual and inter-study
      high variability in colostrum's vitamin content endorses its sensitivity to
      external factors.

PMID- 29843447
TI  - Particulate Matter and Gaseous Pollutions in Three Metropolises along the Chinese
      Yangtze River: Situation and Implications.
AB  - The situation of criteria atmospheric pollutants, including particulate matter
      and trace gases (SO2, NO2, CO and O3), over three metropolises (Chongqing, Wuhan,
      and Nanjing), representing the upstream, midstream and downstream portions of the
      Yangtze River Basin from September 2015 to August 2016 were analyzed. The maximum
      annual mean PM2.5 and PM10 concentrations were 61.3 and 102.7 MUg/m3 in Wuhan,
      while highest annual average gaseous pollutions occurred in Nanjing, with 49.6
      and 22.9 ppb for 8 h O3 and NO2, respectively. Compared to a few years ago, SO2
      and CO mass concentrations have dropped to well below the qualification
      standards, and the O3 and NO2 concentrations basically meet the requirements
      though occasionally is still high. In contrary, about 13%, 25%, 22% for PM2.5,
      and 4%, 17%, 15% for PM10 exceed the Chinese Ambient Air Quality Standard (CAAQS)
      Grade II. Particulate matter, especially PM2.5, is the most frequent major
      pollutant to poor air quality with 73%, 64% and 88% accounting for substandard
      days. Mean PM2.5 concentrations on PM2.5 episode days are 2-3 times greater than
      non-episode days. On the basis of calculation of PM2.5/PM10 and PM2.5/CO ratios,
      the enhanced particulate matter pollution on episode days is closely related to
      secondary aerosol production. Except for O3, the remaining five pollutants
      exhibit analogous seasonal patterns, with the highest magnitude in winter and
      lowest in summer. The results of back trajectories show that air pollution
      displays synergistic effects on local emissions and long range transport. O3
      commonly demonstrated negative correlations with other pollutants, especially
      during winter, while moderate to strong positive correlation between particulate
      matter and NO2, SO2, CO were seen. Compared to pollutant substandard ratios over
      three megacities in eastern China (Beijing, Shanghai, and Guangzhou), the
      situation in our studied second-tier cities are also severe. The results in this
      paper provide basic knowledge for pollution status of three cities along Chinese
      Yangtze River and are conductive to mitigating future negative air quality
      levels.

PMID- 29843448
TI  - Viability, Enzymatic and Protein Profiles of Pseudomonas aeruginosa Biofilm and
      Planktonic Cells after Monomeric/Gemini Surfactant Treatment.
AB  - This study set out to investigate the biological activity of monomeric
      surfactants dodecyltrimethylammonium bromide (DTAB) and the next generation
      gemini surfactant hexamethylene-1,6-bis-(N,N-dimethyl-N-dodecylammonium bromide)
      (C6) against the environmental strain Pseudomonas aeruginosa PB_1. Minimal
      inhibitory concentrations (MIC) were determined using the dilution method. The
      viability of the planktonic cells and biofilm was assessed using the plate count
      method. Enzymatic profile was determined using the API-ZYM system. Proteins were
      extracted from the biofilm and planktonic cells and analysed using SDS-PAGE. The
      MIC of the gemini surfactants was 70 times lower than that of its monomeric
      analogue. After 4 h of treatment at MIC (0.0145 mM for C6 and 1.013 mM for DTAB),
      the number of viable planktonic cells was reduce by less than 3 logarithm units.
      At the concentration >=MIC, a reduction in the number of viable cells was
      observed in mature biofilms (p < 0.05). Treatment for 4 h with gemini surfactant
      at 20 MIC caused complete biofilm eradication. At sub-MIC, the concentration of
      some enzymes reduced and their protein profiles changed. The results of this
      study show that due to its superior antibacterial activity, gemini compound C6
      can be applied as an effective microbiocide against P. aeruginosa in both
      planktonic and biofilm forms.

PMID- 29843449
TI  - Are Front-of-Package Warning Labels More Effective at Communicating Nutrition
      Information than Traffic-Light Labels? A Randomized Controlled Experiment in a
      Brazilian Sample.
AB  - BACKGROUND: Brazil is currently debating the implementation of front-of-package
      labels. This study tested if Warning labels (WLs) improved consumer
      understanding, perceptions, and purchase intentions compared to Traffic-Light
      labels (TLLs) in 1607 Brazilian adults. METHODS: In this online, randomized
      controlled experiment participants saw images of 10 products and answered
      questions twice-once in a no-label, control condition and then again in a
      randomly assigned label condition. The relative differences in responses between
      WLs and TLLs between control and label conditions were estimated using one-way
      ANOVAs or Chi-square tests. RESULTS: Presenting WLs on products compared to TLLs
      helped participants: (i) improve their understanding of excess nutrient content
      (27.0% versus 8.2%, p < 0.001); (ii) improve their ability to identify the
      healthier product (24.6% versus 3.3%, p < 0.001); (iii) decrease perceptions of
      product healthfulness; and (iv) correctly identify healthier products (14.0%
      versus 6.9%, p < 0.001), relative to the control condition. With WLs, there was
      also an increase in the percentage of people: (v) expressing an intention to
      purchase the relatively healthier option (16.1% versus 9.8%, p < 0.001); and (vi)
      choosing not to buy either product (13.0% versus 2.9%, p < 0.001), relative to
      the control condition. The participants in the WL condition had significantly
      more favorable opinions of the labels compared to those in the TLL group.
      CONCLUSIONS: WLs would be more effective at improving consumer food choices.

PMID- 29843450
TI  - Structural Biology of STAT3 and Its Implications for Anticancer Therapies
      Development.
AB  - Transcription factors are proteins able to bind DNA and induce the transcription
      of specific genes. Consequently, they play a pivotal role in multiple cellular
      pathways and are frequently over-expressed or dysregulated in cancer. Here, we
      will focus on a specific "signal transducer and activator of transcription"
      (STAT3) factor that is involved in several pathologies, including cancer. For
      long time, the mechanism by which STAT3 exerts its cellular functions has been
      summarized by a three steps process: (1) Protein phosphorylation by specific
      kinases, (2) dimerization promoted by phosphorylation, (3) activation of gene
      expression by the phosphorylated dimer. Consequently, most of the inhibitors
      reported in literature aimed at blocking phosphorylation and dimerization.
      However, recent observations reopened the debate and the entire functional
      mechanism has been revisited stimulating the scientific community to pursue new
      inhibition strategies. In particular, the dimerization of the unphosphorylated
      species has been experimentally demonstrated and specific roles proposed also for
      these dimers. Despite difficulties in the expression and purification of the full
      length STAT3, structural biology investigations allowed the determination of
      atomistic structures of STAT3 dimers and several protein domains. Starting from
      this information, computational methods have been used both to improve the
      understanding of the STAT3 functional mechanism and to design new inhibitors to
      be used as anticancer drugs. In this review, we will focus on the contribution of
      structural biology to understand the roles of STAT3, to design new inhibitors and
      to suggest new strategies of pharmacological intervention.

PMID- 29843451
TI  - In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin
      3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea.
AB  - Green tea has been shown to have beneficial effects on many diseases such as
      cancer, obesity, inflammatory diseases, and neurodegenerative disorders. The
      major green tea component, epigallocatechin-3-O-gallate (EGCG), has been
      demonstrated to contribute to these effects through its anti-oxidative and pro
      oxidative properties. Furthermore, several lines of evidence have indicated that
      the binding affinity of EGCG to specific proteins may explain its mechanism of
      action. This review article aims to reveal how EGCG-protein interactions can
      explain the mechanism by which green tea/EGCG can exhibit health beneficial
      effects. We conducted a literature search, using mainly the PubMed database. The
      results showed that several methods such as dot assays, affinity gel
      chromatography, surface plasmon resonance, computational docking analyses, and X
      ray crystallography have been used for this purpose. These studies have provided
      evidence to show how EGCG can fit or occupy the position in or near functional
      sites and induce a conformational change, including a quaternary conformational
      change in some cases. Active site blocking, steric hindrance by binding of EGCG
      near an active site or induced conformational change appeared to cause inhibition
      of enzymatic activity and other biological activities of proteins, which are
      related to EGCG's biological oligomer and formation of their toxic aggregates,
      leading to the prevention of neurodegenerative diseases and amyloidosis. In
      conclusion, these studies have provided useful information on the action of green
      tea/catechins and would lead to future studies that will provide further evidence
      for rational EGCG therapy and use EGCG as a lead compound for drug design.

PMID- 29843452
TI  - Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram
      Negative Bacterium Aequorivita sp.
AB  - The combination of LC-MS/MS based metabolomics approach and anti-MRSA activity
      guided fractionation scheme was applied on the Gram-negative bacterium
      Aequorivita sp. isolated from shallow Antarctic sea sediment using a miniaturized
      culture chip technique. This methodology afforded the isolation of three new (1
      3) and four known (4-7) N-terminal glycine- or serine-bearing iso-fatty acid
      amides esterified with another iso-fatty acid through their C-3 hydroxy groups.
      The chemical structures of the new compounds were elucidated using a set of
      spectroscopic (NMR, [alpha]D and FT-IR) and spectrometric (HRMS, HRMS/MS)
      methods. The aminolipids possessing an N-terminal glycine unit (1, 2, 4, 5)
      showed moderate in vitro antimicrobial activity against MRSA (IC50 values 22-145
      MUg/mL). This is the first in-depth chemistry and biological activity study
      performed on the microbial genus Aequorivita.

PMID- 29843453
TI  - Waveform Optimization for Target Estimation by Cognitive Radar with Multiple
      Antennas.
AB  - A new scheme based on Kalman filtering to optimize the waveforms of an adaptive
      multi-antenna radar system for target impulse response (TIR) estimation is
      presented. This work aims to improve the performance of TIR estimation by making
      use of the temporal correlation between successive received signals, and minimize
      the mean square error (MSE) of TIR estimation. The waveform design approach is
      based upon constant learning from the target feature at the receiver. Under the
      multiple antennas scenario, a dynamic feedback loop control system is established
      to real-time monitor the change in the target features extracted form received
      signals. The transmitter adapts its transmitted waveform to suit the time
      invariant environment. Finally, the simulation results show that, as compared
      with the waveform design method based on the MAP criterion, the proposed waveform
      design algorithm is able to improve the performance of TIR estimation for
      extended targets with multiple iterations, and has a relatively lower level of
      complexity.

PMID- 29843454
TI  - Experimental Effects of Acute Exercise and Meditation on Parameters of Cognitive
      Function.
AB  - Single bouts of aerobic exercise and meditation have been shown to improve
      cognitive function. Yet to be examined in the literature, we sought to examine
      the effects of a combination of acute bouts of aerobic exercise and meditation on
      cognitive function among young adults. Participants (n = 66, mean (SD) age = 21
      (2)) were randomly assigned to walk then meditate, meditate then walk, or to sit
      (inactive control). All walking and meditation bouts were 10 min in duration.
      Participants' cognition was monitored before and after the intervention using
      Identification, Set Shifting, Stroop, and Trail Making tasks. Additionally, a
      subjective assessment of cognitive function was implemented before and after the
      intervention. Significant group by time interaction effects were observed when
      examining the Stroop congruent trials (P = 0.05). Post hoc paired t-tests
      revealed that reaction time significantly decreased from baseline to post
      intervention in both combination groups (P < 0.001 for both), but not in the
      control group (P = 0.09). Regarding all other cognitive assessments, there were
      no significant group by time interaction effects (P > 0.05). Cognitive function
      was not substantially affected by a combination of brief meditation and exercise,
      though there is evidence to suggest that this combination may have beneficial
      effects on certain aspects of cognition. Future work should be conducted to
      evaluate the influences of different doses of exercise and meditation on
      cognitive functioning.

PMID- 29843455
TI  - Changes in Photosynthetic Pigments, Total Phenolic Content, and Antioxidant
      Activity of Salvia coccinea Buc'hoz Ex Etl. Induced by Exogenous Salicylic Acid
      and Soil Salinity.
AB  - Salvia coccinea (Lamiaceae) is a promising source of potential antioxidants, and
      its extracts can be used in pharmaceutical industry, as well as in food products
      and cosmetics. Salicylic acid (SA) affects many physiological and metabolic
      processes in vascular plants under salinity stress. The aim of this study was to
      investigate the response of S. coccinea to either SA, or sodium chloride (NaCl),
      or a combination of both. The plants were sprayed with a solution of 0.5 or 1.0
      mM SA and watered with 0, 100, 200, or 300 mM NaCl. Exogenous application of SA
      increased the number of branches, fresh herbal weight, and total chlorophyll
      content vs control plants. Salinity-exposed plants showed reduced growth, content
      of photosynthetic pigments total polyphenols, and antioxidant activity. However,
      foliar application of SA relieved the adverse effects of 100 mM NaCl, as
      demonstrated by increased number of branches, greater fresh herbal weight, higher
      content of total chlorophyll, total carotenoids, and total polyphenols, as well
      as antioxidant potential, detected using ferric-reducing ability of plasma (FRAP)
      and 2.2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt
      (ABTS), compared with untreated plants.

PMID- 29843456
TI  - Carbon Nanotube Field Emitters Synthesized on Metal Alloy Substrate by PECVD for
      Customized Compact Field Emission Devices to Be Used in X-Ray Source
      Applications.
AB  - In this study, a simple, efficient, and economical process is reported for the
      direct synthesis of carbon nanotube (CNT) field emitters on metal alloy. Given
      that CNT field emitters can be customized with ease for compact and cold field
      emission devices, they are promising replacements for thermionic emitters in
      widely accessible X-ray source electron guns. High performance CNT emitter
      samples were prepared in optimized plasma conditions through the plasma-enhanced
      chemical vapor deposition (PECVD) process and subsequently characterized by using
      a scanning electron microscope, tunneling electron microscope, and Raman
      spectroscopy. For the cathode current, field emission (FE) characteristics with
      respective turn on (1 MUA/cm2) and threshold (1 mA/cm2) field of 2.84 and 4.05
      V/MUm were obtained. For a field of 5.24 V/MUm, maximum current density of 7
      mA/cm2 was achieved and a field enhancement factor beta of 2838 was calculated.
      In addition, the CNT emitters sustained a current density of 6.7 mA/cm2 for 420
      min under a field of 5.2 V/MUm, confirming good operational stability. Finally,
      an X-ray generated image of an integrated circuit was taken using the compact
      field emission device developed herein.

PMID- 29843458
TI  - Association between Serum 25-Hydroxy Vitamin D Levels and the Prevalence of Adult
      Onset Asthma.
AB  - The major circulating metabolite of vitamin D (25(OH)D) has been implicated in
      the pathogenesis for atopic dermatitis, asthma and other allergic diseases due to
      downstream immunomodulatory effects. However, a consistent association between
      25(OH)D and asthma during adulthood has yet to be found in observational studies.
      We aimed to test the association between 25(OH)D and asthma during adulthood and
      hypothesised that this association would be stronger in non-atopic participants.
      Using information collected on the participants of the 1958 birth cohort, we
      developed a novel measure of atopic status using total and specific IgE values
      and reported history of eczema and allergic rhinitis. We designed a nested case
      control analysis, stratified by atopic status, and using logistic regression
      models investigated the association between 25(OH)D measured at age 46 years with
      the prevalence of asthma and wheezy bronchitis at age 50 years, excluding
      participants who reported ever having asthma or wheezy bronchitis before the age
      of 42. In the fully adjusted models, a 10 nmol/L increase in serum 25(OH)D
      prevalence had a significant association with asthma (aOR 0.94; 95% CI 0.88
      1.00). There was some evidence of an atopic dependent trend in the association
      between 25(OH)D levels and asthma. Further analytical work on the
      operationalisation of atopy status would prove useful to uncover whether there is
      a role for 25(OH)D and other risk factors for asthma.

PMID- 29843457
TI  - Taurine Supplementation Alleviates Puromycin Aminonucleoside Damage by Modulating
      Endoplasmic Reticulum Stress and Mitochondrial-Related Apoptosis in Rat Kidney.
AB  - Taurine (TAU) is a sulfur-containing beta amino acid that is not involved in
      protein composition and anabolism, conditionally essential in mammals provided
      through diet. Growing evidence supports a protective role of TAU supply in
      osmoregulation, calcium flux, and reduction of inflammation and oxidant damage in
      renal diseases like diabetes. Endoplasmic reticulum (ER) stress, due to abnormal
      proteostasis, is a contributor to nephrotic syndrome and related renal damage.
      Here, we investigated the effect of dietary TAU (1.5% in drinking water for 15
      days) in an established rat model that mimics human minimal change nephrosis,
      consisting of a single puromycin aminonucleoside (PAN) injection
      (intraperitoneally 15 mg/100 g body weight), with sacrifice after eight days. TAU
      limited proteinuria and podocytes foot processes effacement, and balanced slit
      diaphragm nephrin and glomerular claudin 1 expressions. In cortical proximal
      tubules, TAU improved lysosomal density, ER perimeter, restored proper ER
      mitochondria tethering and mitochondrial cristae, and decreased inflammation.
      Remarkably, TAU downregulated glomerular ER stress markers (GRP78, GRP94), pro
      apoptotic C/EBP homologous protein, activated caspase 3, tubular caspase1, and
      mitochondrial chaperone GRP75, but maintained anti-apoptotic HSP25. In
      conclusion, TAU, by targeting upstream ER stress separate from mitochondria
      dysfunctions at crucial renal sites, might be a promising dietary supplement in
      the treatment of the drug-resistant nephrotic syndrome.

PMID- 29843459
TI  - Temporal Stability of GPS Transmitter Group Delay Variations.
AB  - The code observable of global navigation satellite systems (GNSS) is influenced
      by group delay variations (GDV) of transmitter and receiver antennas. For the
      Global Positioning System (GPS), the variations can sum up to 1 m in the
      ionosphere-free linear combination and thus can significantly affect precise code
      applications. The contribution of the GPS transmitters can amount to 0.8 m peak
      to-peak over the entire nadir angle range. To verify the assumption of their time
      invariance, we determined daily individual satellite GDV for GPS transmitter
      antennas over a period of more than two years. Dual-frequency observations of
      globally distributed reference stations and their multipath combination form the
      basis for our analysis. The resulting GPS GDV are stable on the level of a few
      centimeters for C1, P2, and for the ionosphere-free linear combination. Our study
      reveals that the inconsistencies of the GDV of space vehicle number (SVN) 55 with
      respect to earlier studies are not caused by temporal instabilities, but are
      rather related to receiver properties.

PMID- 29843460
TI  - Coextrusion-Based 3D Plotting of Ceramic Pastes for Porous Calcium Phosphate
      Scaffolds Comprised of Hollow Filaments.
AB  - This paper demonstrates the utility of coextrusion-based 3D plotting of ceramic
      pastes (CoEx-3DP) as a new type of additive manufacturing (AM) technique, which
      can produce porous calcium phosphate (CaP) ceramic scaffolds comprised of hollow
      CaP filaments. In this technique, green filaments with a controlled core/shell
      structure can be produced by coextruding an initial feedrod, comprised of the
      carbon black (CB) core and CaP shell, through a fine nozzle in an acetone bath
      and then deposited in a controlled manner according to predetermined paths. In
      addition, channels in CaP filaments can be created through the removal of the CB
      cores during heat-treatment. Produced CaP scaffolds had two different types of
      pores with well-defined geometries: three-dimensionally interconnected pores
      (~360 * 230 MUm2 in sizes) and channels (>100 MUm in diameter) in hollow CaP
      filaments. The porous scaffolds showed high compressive strengths of ~12.3 +/-
      2.2 MPa at a high porosity of ~73 vol % when compressed parallel to the direction
      of the hollow CaP filaments. In addition, the mechanical properties of porous CaP
      scaffolds could be tailored by adjusting their porosity, for example, compressive
      strengths of 4.8 +/- 1.1 MPa at a porosity of ~82 vol %. The porous CaP scaffold
      showed good biocompatibility, which was assessed by in vitro cell tests, where
      several the cells adhered to and spread actively with the outer and inner
      surfaces of the hollow CaP filaments.

PMID- 29843461
TI  - Inverse Piezoresistive Nanocomposite Sensors for Identifying Human Sitting
      Posture.
AB  - Sitting posture is the position in which one holds his/her body upright against
      gravity while sitting. Poor sitting posture is regarded as an aggravating factor
      for various diseases. In this paper, we present an inverse piezoresistive
      nanocomposite sensor, and related deciphering neural network, as a new tool to
      identify human sitting postures accurately. As a low power consumption device,
      the proposed tool has simple structure, and is easy to use. The strain gauge is
      attached to the back of the user to acquire sitting data. A three-layer BP neural
      network is employed to distinguish normal sitting posture, slight hunchback and
      severe hunchback according to the acquired data. Experimental results show that
      our method is both realizable and effective, achieving 98.75% posture
      identification accuracy. This successful application of inverse piezoresistive
      nanocomposite sensors reveals that the method could potentially be used for
      monitoring of diverse physiological parameters in the future.

PMID- 29843462
TI  - Testing the Domino Theory of Gene Loss in Buchnera aphidicola: The Relevance of
      Epistatic Interactions.
AB  - The domino theory of gene loss states that when some particular gene loses its
      function and cripples a cellular function, selection will relax in all
      functionally related genes, which may allow for the non-functionalization and
      loss of these genes. Here we study the role of epistasis in determining the
      pattern of gene losses in a set of genes participating in cell envelope
      biogenesis in the endosymbiotic bacteria Buchnera aphidicola. We provide
      statistical evidence indicating pairs of genes in B. aphidicola showing
      correlated gene loss tend to have orthologs in Escherichia coli known to have
      alleviating epistasis. In contrast, pairs of genes in B. aphidicola not showing
      correlated gene loss tend to have orthologs in E. coli known to have aggravating
      epistasis. These results suggest that during the process of genome reduction in
      B. aphidicola by gene loss, positive or alleviating epistasis facilitates
      correlated gene losses while negative or aggravating epistasis impairs correlated
      gene losses. We interpret this as evidence that the reduced proteome of B.
      aphidicola contains less pathway redundancy and more compensatory interactions,
      mimicking the situation of E. coli when grown under environmental constrains.

PMID- 29843463
TI  - Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer
      Therapeutics.
AB  - Restoration of wild-type structure and function to mutant p53 with a small
      molecule (hereafter referred to as "reactivating" mutant p53) is one of the holy
      grails in cancer therapeutics. The majority of TP53 mutations are missense which
      generate a defective protein that is targetable. We are currently developing a
      new class of mutant p53 reactivators called zinc metallochaperones (ZMCs) and,
      here, we review our current understanding of them. The p53 protein requires the
      binding of a single zinc ion, coordinated by four amino acids in the DNA binding
      domain, for proper structure and function. Loss of the wild-type structure by
      impairing zinc binding is a common mechanism of inactivating p53. ZMCs reactivate
      mutant p53 using a novel two-part mechanism that involves restoring the wild-type
      structure by reestablishing zinc binding and activating p53 through post
      translational modifications induced by cellular reactive oxygen species (ROS).
      The former causes a wild-type conformation change, the later induces a p53
      mediated apoptotic program to kill the cancer cell. ZMCs are small molecule metal
      ion chelators that bind zinc and other divalent metal ions strong enough to
      remove zinc from serum albumin, but weak enough to donate it to mutant p53.
      Recently we have extended our understanding of the mechanism of ZMCs to the role
      of cells' response to this zinc surge. We found that cellular zinc homeostatic
      mechanisms, which normally function to maintain free intracellular zinc levels in
      the picomolar range, are induced by ZMCs. By normalizing zinc levels, they
      function as an OFF switch to ZMCs because zinc levels are no longer sufficiently
      high to maintain a wild-type structure. This on/off switch leads to a transient
      nature to the mechanism of ZMCs in which mutant p53 activity comes on in a few
      hours and then is turned off. This finding has important implications for the
      translation of ZMCs to the clinic because it indicates that ZMC concentrations
      need not be maintained at high levels for their activity. Indeed, we found that
      short exposures (as little as 15 min) were adequate to observe the mutant p53
      reactivating activity. This switch mechanism imparts an advantage over other
      targeted therapeutics in that efficacy can be accomplished with minimal exposure
      which minimizes toxicity and maximizes the therapeutic window. This on/off switch
      mechanism is unique in targeted cancer therapeutics and will impact the design of
      human clinical trials.

PMID- 29843464
TI  - Involving Patients and Families in the Analysis of Suicides, Suicide Attempts,
      and Other Sentinel Events in Mental Healthcare: A Qualitative Study in The
      Netherlands.
AB  - Involving patients and families in mental healthcare is becoming more
      commonplace, but little is known about how they are involved in the aftermath of
      serious adverse events related to quality of care (sentinel events, including
      suicides). This study explores the role patients and families have in formal
      processes after sentinel events in Dutch mental healthcare. We analyzed the
      existing policies of 15 healthcare organizations and spoke with 35 stakeholders
      including patients, families, their counselors, the national regulator, and
      professionals. Respondents argue that involving patients and families is valuable
      to help deal with the event emotionally, provide additional information, and
      prevent escalation. Results indicate that involving patients and families is only
      described in sentinel event policies to a limited extent. In practice,
      involvement consists mostly of providing aftercare and sharing information about
      the event by providers. Complexities such as privacy concerns and involuntary
      admissions are said to hinder involvement. Respondents also emphasize that
      involvement should not be obligatory and stress the need for patients and
      families to be involved throughout the process of treatment. There is no one-size
      fits-all strategy for involving patients and families after sentinel events. The
      first step seems to be early involvement during treatment process itself.

PMID- 29843465
TI  - Coronary Stents: History, Design, and Construction.
AB  - The history of percutaneous coronary intervention (PCI) is marked by rapid
      technological advancements that have taken place over the past 40 years. After a
      period of balloon angioplasty, which was marred by risk of abrupt vessel closure
      and vessel recoil, balloon expandable metal alloy stents were the mainstay of
      PCI. The introduction of drug eluting stents (DES) targeted in-stent restenosis,
      a common mode of stent failure, and ushered in the current PCI era. Since the
      first generation of DES, advances in polymer science and stent design have
      advanced the field. The current generation of DES has thin struts, are highly
      deliverable, have biocompatible or absorbable polymers, and outstanding safety
      and efficacy profiles. In this review, we discuss the technological advancements
      in stent development, design, and construction, with an emphasis on balloon
      expandable stents. The aspects of stent properties, metal alloys, bioresorbable
      vascular scaffolds, drug elution, and polymers will be covered.

PMID- 29843466
TI  - Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases.
AB  - Tea is one of the most consumed beverages in the world. Green tea, black tea, and
      oolong tea are made from the same plant Camellia sinensis (L.) O. Kuntze. Among
      them, green tea has been the most extensively studied for beneficial effects on
      diseases including cancer, obesity, diabetes, and inflammatory and
      neurodegenerative diseases. Several human observational and intervention studies
      have found beneficial effects of tea consumption on neurodegenerative impairment,
      such as cognitive dysfunction and memory loss. These studies supported the basis
      of tea's preventive effects of Parkinson's disease, but few studies have revealed
      such effects on Alzheimer's disease. In contrast, several human studies have not
      reported these favorable effects with regard to tea. This discrepancy may be due
      to incomplete adjustment of confounding factors, including the method of
      quantifying consumption, beverage temperature, cigarette smoking, alcohol
      consumption, and differences in genetic and environmental factors, such as race,
      sex, age, and lifestyle. Thus, more rigorous human studies are required to
      understand the neuroprotective effect of tea. A number of laboratory experiments
      demonstrated the benefits of green tea and green tea catechins (GTCs), such as
      epigallocatechin gallate (EGCG), and proposed action mechanisms. The targets of
      GTCs include the abnormal accumulation of fibrous proteins, such as Abeta and
      alpha-synuclein, inflammation, elevated expression of pro-apoptotic proteins, and
      oxidative stress, which are associated with neuronal cell dysfunction and death
      in the cerebral cortex. Computational molecular docking analysis revealed how
      EGCG can prevent the accumulation of fibrous proteins. These findings suggest
      that GTCs have the potential to be used in the prevention and treatment of
      neurodegenerative diseases and could be useful for the development of new drugs.

PMID- 29843467
TI  - Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier
      Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm
      Infants.
AB  - Preterm infants require fortification of human milk (HM) with essential fatty
      acids (FA) to ensure adequate post-natal development. As part of a larger
      randomized controlled study, we investigated FA metabolism in a subset of 47
      clinically stable preterm infants (birth weight <=1500 g or gestational age <=32
      weeks). Infants were randomized to receive HM supplemented with either a new HM
      fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg
      linoleic acid (LA), 417 mg alpha-linolenic acid (ALA), and 157 mg docosahexaenoic
      acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a
      fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG),
      and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC
      PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF
      group, significantly increased levels of n-9 monounsaturated fatty acids were
      observed, formed most likely by elongation and desaturation of dietary saturated
      fatty acids present in HM. ALA fortification increased ALA assimilation into
      plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE,
      which, in this compartment, was not associated with lower arachidonic acid levels
      as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA
      metabolism and accretion, was the most sensitive compartment in this study.

PMID- 29843468
TI  - Influence of Personality Traits on the Severity of Alcohol Use Disorders.
AB  - INTRODUCTION: Alcohol Use Disorders (AUD) are the most prevalent psychiatric
      diagnosis in the general population. The study of personality characteristics,
      using Cloninger Personality Inventory (TCI-R), allows us to know the evolution of
      these patients at the beginning of treatment. MATERIAL AND METHOD: We conducted a
      cross-sectional, observational and descriptive study for 3 years with a total of
      304 patients. We studied the severity of their alcohol disorder by the Alcohol
      Dependency Intensity Scale (EIDA), Scale of Obsessive Consumption Compulsive
      (OCDS) and European version of the Addiction Severity Index (EUROPASI); we
      studied the relationship with the personality traits of TCI-R. RESULTS AND
      CONCLUSIONS: The personality lines influence the evolution of alcohol use
      disorder (AUD). People with higher scores on Reward Dependency (RD), Persistence
      (P), Cooperation (CO) and Autotranscendence (ST) have a better prognosis while
      people with higher scores on Search for Novelty (SN) and Avoidance of Damage (AD)
      have a worst prognosis. Women present differences in consumption in relation to
      men, as a consequence of their personality. Women have lower scores in
      Persistence (P) y Self-Transcendence (ST) which are associated with the greater
      severity of their addiction.

PMID- 29843469
TI  - LDLR rs688 TT Genotype and T Allele Are Associated with Increased Susceptibility
      to Coronary Artery Disease-A Case-Control Study.
AB  - PURPOSE: The low-density lipoprotein receptor is responsible for the binding and
      uptake of plasma LDL particles and plays a critical role in maintaining cellular
      cholesterol homeostasis. LDLR gene SNP rs688 has been reported to be associated
      with increased plasma total and LDL cholesterol in several populations and can
      lead to elevated plasma LDL levels, resulting in an increased risk for
      atherosclerosis and coronary artery disease. This study aimed to explore genetic
      LDLR variant rs688 for its potential roles in coronary artery disease.
      METHODOLOGY: This study recruited 200 coronary artery disease patients and 200
      healthy individuals. Genotyping of LDLR-rs688C > T gene variations was performed
      using the allele specific PCR method. Correlation of LDLR-rs688C > T gene
      variants with different clinicopathological features of coronary artery disease
      patients was performed. Pooled odds ratios (ORs) and 95% confidence intervals
      (CIs) were applied to evaluate the correlation of this microRNA polymorphism with
      coronary artery disease risk. RESULTS: A significant difference was observed in
      genotype distribution among the coronary artery disease and matched healthy
      controls (p = 0.003). The frequencies of all three genotypes CC, CT, TT reported
      in the patient samples were 14%, 65% and 21% and in the healthy controls samples
      were 18%, 73% and 9%, respectively. The increased risk of developing CAD in
      Indian patients was found to be associated with LDLR rs688 TT genotype (OR = 3.0,
      95% CI, 1.43 * 6.2; p = 0.003) RR 1.87 (1.20-2.91) p = 0.0037) and also the
      increased risk of developing CAD was reported to be associated with LDLR rs688 T
      allele (OR = 0.74, 95% CI, 1.57-0.97; p = 0.03) RR 0.85 (0.73-0.99) p = 0.03)
      compared to the C allele. Therefore, it was observed that more than a 3.0- and
      0.74-fold increase risk of developing CAD was associated with TT genotype and T
      allele in Indian coronary artery disease patients. CONCLUSION: The findings
      indicated that LDLR rs688 TT genotype and T allele are associated with an
      increased susceptibility to coronary artery disease patients. LDLR-rs688C > T
      gene variation can be used as a predisposing genetic marker for coronary artery
      disease. Further studies with larger sample sizes are necessary to confirm our
      findings.

PMID- 29843471
TI  - The Selectivity of Polymers Imprinted with Amines.
AB  - One of the main reasons for making molecularly imprinted polymers (MIPs) has been
      that MIPs interact selectively with a specific target compound. This claim is
      investigated here with the example of a widely used type of noncovalent MIP, the
      MIP for the beta blocker propranolol. Adsorption isotherms of this MIP and of a
      nonimprinted control polymer (NIP), respectively, have been measured with a
      series of compounds in the porogen solvent acetonitrile. The results, visualized
      as "selectivity ladders", show that the MIP binds propranolol and many other
      amines better than the NIP does, but the selectivity of the MIP is actually
      inferior to that of the NIP. The selectivity of either polymer for propranolol is
      modest against many amines, but is remarkable with respect to other compounds.
      The contribution of imprinting towards selectivity can be better appreciated when
      three MIPs, made with different amine templates, are compared among themselves.
      Each MIP is seen to bind its own template slightly better than the other two MIPs
      do. In media different from the porogen, the selectivity patterns may change
      substantially. Propranolol seems to have properties that make it stand high on
      the selectivity scale in different solvents, albeit for different reasons.

PMID- 29843470
TI  - Recognizing Depression from the Microbiota-Gut-Brain Axis.
AB  - Major depression is one of the leading causes of disability, morbidity, and
      mortality worldwide. The brain-gut axis functions are disturbed, revealed by a
      dysfunction of the brain, immune system, endocrine system, and gut. Traditional
      depression treatments all target the brain, with different drugs and/or
      psychotherapy. Unfortunately, most of the patients have never received any
      treatment. Studies indicate that gut microbiota could be a direct cause for the
      disorder. Abnormal microbiota and the microbiota-gut-brain dysfunction may cause
      mental disorders, while correcting these disturbance could alleviate depression.
      Nowadays, the gut microbiota modulation has become a hot topic in treatment
      research of mental disorders. Depression is closely related with the health
      condition of the brain-gut axis, and maintaining/restoring the normal condition
      of gut microbiota helps in the prevention/therapy of mental disorders.

PMID- 29843472
TI  - Transcriptional Profiles of SmWRKY Family Genes and Their Putative Roles in the
      Biosynthesis of Tanshinone and Phenolic Acids in Salvia miltiorrhiza.
AB  - Salvia miltiorrhiza Bunge is a Chinese traditional herb for treating
      cardiovascular and cerebrovascular diseases, and tanshinones and phenolic acids
      are the dominated medicinal and secondary metabolism constituents of this plant.
      WRKY transcription factors (TFs) can function as regulators of secondary
      metabolites biosynthesis in many plants. However, studies on the WRKY that
      regulate tanshinones and phenolics biosynthesis are limited. In this study, 69
      SmWRKYs were identified in the transcriptome database of S. miltiorrhiza, and
      phylogenetic analysis indicated that some SmWRKYs had closer genetic
      relationships with other plant WRKYs, which were involved in secondary
      metabolism. Hairy roots of S. miltiorrhiza were treated by methyl jasmonate
      (MeJA) to detect the dynamic change trend of SmWRKY, biosynthetic genes, and
      medicinal ingredients accumulation. Base on those date, a correlation analysis
      using Pearson's correlation coefficient was performed to construct gene-to
      metabolite network and identify 9 SmWRKYs (SmWRKY1, 7, 19, 29, 45, 52, 56, 58,
      and 68), which were most likely to be involved in tanshinones and phenolic acids
      biosynthesis. Taken together, this study has provided a significant resource that
      could be used for further research on SmWRKY in S. miltiorrhiza and especially
      could be used as a cue for further investigating SmWRKY functions in secondary
      metabolite accumulation.

PMID- 29843473
TI  - In Vitro Studies of Lipopolysaccharide-Mediated DNA Release of Podovirus HK620.
AB  - Gram-negative bacteria protect themselves with an outermost layer containing
      lipopolysaccharide (LPS). O-antigen-specific bacteriophages use tailspike
      proteins (TSP) to recognize and cleave the O-polysaccharide part of LPS. However,
      O-antigen composition and structure can be highly variable depending on the
      environmental conditions. It is important to understand how these changes may
      influence the early steps of the bacteriophage infection cycle because they can
      be linked to changes in host range or the occurrence of phage resistance. In this
      work, we have analyzed how LPS preparations in vitro trigger particle opening and
      DNA ejection from the E. coli podovirus HK620. Fluorescence-based monitoring of
      DNA release showed that HK620 phage particles in vitro ejected their genome at
      velocities comparable to those found for other podoviruses. Moreover, we found
      that HK620 irreversibly adsorbed to the LPS receptor via its TSP at restrictive
      low temperatures, without opening the particle but could eject its DNA at
      permissive temperatures. DNA ejection was solely stimulated by LPS, however, the
      composition of the O-antigen dictated whether the LPS receptor could start the
      DNA release from E. coli phage HK620 in vitro. This finding can be significant
      when optimizing bacteriophage mixtures for therapy, where in natural environments
      O-antigen structures may rapidly change.

PMID- 29843475
TI  - Surface Characterization of Mesoporous CoOx/SBA-15 Catalyst upon 1,2
      Dichloropropane Oxidation.
AB  - The active combustion catalyst that is based on 30 wt % cobalt oxide on
      mesoporous SBA-15 has been tested in 1,2-dichloropropane oxidation and is
      characterized by means of FT-IR (Fourier transform infrared spectroscopy) and
      ammonia-TPD (temperature-programmed desorption). In this work, we report the
      spectroscopic evidence for the role of surface acidity in chloroalkane
      conversion. Both Lewis acidity and weakly acidic silanol groups from SBA support
      are involved in the adsorption and initial conversion steps. Moreover, total
      oxidation reaction results in the formation of new Bronsted acidic sites, which
      are likely associated with the generation of HCl at high temperature and its
      adsorption at the catalyst surface. Highly dispersed Co oxide on the mesoporous
      support and Co-chloride or oxychloride particles, together with the presence of
      several families of acidic sites originated from the conditioning effect of
      reaction products may explain the good activity of this catalyst in the oxidation
      of Chlorinated Volatile Organic Compounds.

PMID- 29843474
TI  - Candidate Genes for Yellow Leaf Color in Common Wheat (Triticum aestivum L.) and
      Major Related Metabolic Pathways according to Transcriptome Profiling.
AB  - The photosynthetic capacity and efficiency of a crop depends on the biosynthesis
      of photosynthetic pigments and chloroplast development. However, little is known
      about the molecular mechanisms of chloroplast development and chlorophyll (Chl)
      biosynthesis in common wheat because of its huge and complex genome. Ygm, a
      spontaneous yellow-green leaf color mutant of winter wheat, exhibits reduced Chl
      contents and abnormal chloroplast development. Thus, we searched for candidate
      genes associated with this phenotype. Comparative transcriptome profiling was
      performed using leaves from the yellow leaf color type (Y) and normal green color
      type (G) of the Ygm mutant progeny. We identified 1227 differentially expressed
      genes (DEGs) in Y compared with G (i.e., 689 upregulated genes and 538
      downregulated genes). Gene ontology and pathway enrichment analyses indicated
      that the DEGs were involved in Chl biosynthesis (i.e., magnesium chelatase
      subunit H (CHLH) and protochlorophyllide oxidoreductase (POR) genes), carotenoid
      biosynthesis (i.e., beta-carotene hydroxylase (BCH) genes), photosynthesis, and
      carbon fixation in photosynthetic organisms. We also identified heat shock
      protein (HSP) genes (sHSP, HSP70, HSP90, and DnaJ) and heat shock transcription
      factor genes that might have vital roles in chloroplast development. Quantitative
      RT-PCR analysis of the relevant DEGs confirmed the RNA-Seq results. Moreover,
      measurements of seven intermediate products involved in Chl biosynthesis and five
      carotenoid compounds involved in carotenoid-xanthophyll biosynthesis confirmed
      that CHLH and BCH are vital enzymes for the unusual leaf color phenotype in Y
      type. These results provide insights into leaf color variation in wheat at the
      transcriptional level.

PMID- 29843477
TI  - Flavor Compounds in Pixian Broad-Bean Paste: Non-Volatile Organic Acids and Amino
      Acids.
AB  - Non-volatile organic acids and amino acids are important flavor compounds in
      Pixian broad-bean paste, which is a traditional Chinese seasoning product. In
      this study, non-volatile organic acids, formed in the broad-bean paste due to the
      metabolism of large molecular compounds, are qualitatively and quantitatively
      determined by high-performance liquid chromatography (HPLC). Amino acids, mainly
      produced by hydrolysis of soybean proteins, were determined by the amino acid
      automatic analyzer. Results indicated that seven common organic acids and
      eighteen common amino acids were found in six Pixian broad-bean paste samples.
      The content of citric acid was found to be the highest in each sample, between
      4.1 mg/g to 6.3 mg/g, and malic acid were between 2.1 mg/g to 3.6 mg/g ranked as
      the second. Moreover, fumaric acid was first detected in fermented bean pastes
      albeit with a low content. For amino acids, savory with lower sour taste
      including glutamine (Gln), glutamic acid (Glu), aspartic acid (Asp) and
      asparagines (Asn) were the most abundant, noted to be 6.5 mg/g, 4.0 mg/g, 6.4
      mg/g, 4.9 mg/g, 6.2 mg/g and 10.2 mg/g, and bitter taste amino acids followed.
      More importantly, as important flavor materials in Pixian broad-bean paste, these
      two groups of substances are expected to be used to evaluate and represent the
      flavor quality of Pixian broad-bean paste. Moreover, the results revealed that
      citric acid, glutamic acid, methionine and proline were the most important flavor
      compounds. These findings are agreat contribution for evaluating the quality and
      further assessment of Pixian broad-bean paste.

PMID- 29843476
TI  - Manipulation of Innate and Adaptive Immunity by Staphylococcal Superantigens.
AB  - Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins
      secreted by Staphylococcus aureus and other select staphylococcal species. SAgs
      function to cross-link major histocompatibility complex (MHC) class II molecules
      with T cell receptors (TCRs) to stimulate the uncontrolled activation of T
      lymphocytes, potentially leading to severe human illnesses such as toxic shock
      syndrome. The ubiquity of SAgs in clinical S. aureus isolates suggests that they
      likely make an important contribution to the evolutionary fitness of S. aureus.
      Although the apparent redundancy of SAgs in S. aureus has not been explained, the
      high level of sequence diversity within this toxin family may allow for SAgs to
      recognize an assorted range of TCR and MHC class II molecules, as well as aid in
      the avoidance of humoral immunity. Herein, we outline the major diseases
      associated with the staphylococcal SAgs and how a dysregulated immune system may
      contribute to pathology. We then highlight recent research that considers the
      importance of SAgs in the pathogenesis of S. aureus infections, demonstrating
      that SAgs are more than simply an immunological diversion. We suggest that SAgs
      can act as targeted modulators that drive the immune response away from an
      effective response, and thus aid in S. aureus persistence.

PMID- 29843479
TI  - A Kinect-Based Segmentation of Touching-Pigs for Real-Time Monitoring.
AB  - Segmenting touching-pigs in real-time is an important issue for surveillance
      cameras intended for the 24-h tracking of individual pigs. However, methods to do
      so have not yet been reported. We particularly focus on the segmentation of
      touching-pigs in a crowded pig room with low-contrast images obtained using a
      Kinect depth sensor. We reduce the execution time by combining object detection
      techniques based on a convolutional neural network (CNN) with image processing
      techniques instead of applying time-consuming operations, such as optimization
      based segmentation. We first apply the fastest CNN-based object detection
      technique (i.e., You Only Look Once, YOLO) to solve the separation problem for
      touching-pigs. If the quality of the YOLO output is not satisfied, then we try to
      find the possible boundary line between the touching-pigs by analyzing the shape.
      Our experimental results show that this method is effective to separate touching
      pigs in terms of both accuracy (i.e., 91.96%) and execution time (i.e., real-time
      execution), even with low-contrast images obtained using a Kinect depth sensor.

PMID- 29843478
TI  - Clinical Importance of Epstein-Barr Virus-Associated Gastric Cancer.
AB  - Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is the most common
      malignancy caused by EBV infection. EBVaGC has definite histological
      characteristics similar to gastric carcinoma with lymphoid stroma. Clinically,
      EBVaGC has a significantly low frequency of lymph node metastasis compared with
      EBV-negative gastric cancer, resulting in a better prognosis. The Cancer Genome
      Atlas of gastric adenocarcinomas proposed a molecular classification divided into
      four molecular subtypes: (1) EBVaGC; (2) microsatellite instability; (3)
      chromosomal instability; and (4) genomically stable tumors. EBVaGC harbors a DNA
      methylation phenotype, PD-L1 and PD-L2 overexpression, and frequent alterations
      in the PIK3CA gene. We review clinical importance of EBVaGC and discuss novel
      therapeutic applications for EBVaGC.

PMID- 29843480
TI  - Heating Characteristics and Induced Healing Efficiencies of Asphalt Mixture via
      Induction and Microwave Heating.
AB  - This paper investigates the heating characteristics and induced healing
      efficiencies of asphalt mixture containing steel fiber under induction heating
      and microwave heating. The heating characteristics of an asphalt mixture with
      different heating methods were studied with an infrared camera. The healing
      performance of the asphalt mixture specimens in different healing conditions were
      investigated by observing the crack closure and testing the fracture resistance
      recovery after healing. The results showed that the heating speed at the surface
      of asphalt mixture with induction heating was much higher than that with
      microwave machine heating, under a similar output power and the same method of
      radiation. While the temperature distribution within the asphalt mixture under
      induction heating was quite uneven, microwave heating resulted in a more uniform
      temperature distribution. The effective heating depth of microwave heating is
      much higher than that of induction heating. Gradient healing occurred within the
      sample heated with induction healing, while a uniform healing effect can be
      achieved with microwave heating.

PMID- 29843481
TI  - Enhanced Enzymatic Hydrolysis and Structural Features of Corn Stover by NaOH and
      Ozone Combined Pretreatment.
AB  - A two-step pretreatment using NaOH and ozone was performed to improve the
      enzymatic hydrolysis, compositions and structural characteristics of corn stover.
      Comparison between the unpretreated and pretreated corn stover was also made to
      illustrate the mechanism of the combined pretreatment. A pretreatment with 2%
      (w/w) NaOH at 80  degrees C for 2 h followed by ozone treatment for 25 min with
      an initial pH 9 was found to be the optimal procedure and the maximum efficiency
      (91.73%) of cellulose enzymatic hydrolysis was achieved. Furthermore, microscopic
      observation of changes in the surface structure of the samples showed that holes
      were formed and lignin and hemicellulose were partially dissolved and removed. X
      ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Cross
      Polarization Magic Angle Spinning Carbon-13 Nuclear Magnetic Resonance (CP/MAS
      13C-NMR) were also used to characterize the chemical structural changes after the
      combined pretreatment. The results were as follows: part of the cellulose I
      structure was destroyed and then reformed into cellulose III, the cellulose
      crystal indices were also changed; a wider space between the crystal layer was
      observed; disruption of hydrogen bonds in cellulose and disruption of ester bonds
      in hemicellulose; cleavage of bonds linkage in lignin-carbohydrate complexes;
      removal of methoxy in lignin and hemicellulose. As a result, all these changes
      effectively reduced recalcitrance of corn stover and promoted subsequent
      enzymatic hydrolysis of cellulose.

PMID- 29843482
TI  - Deciphering RNA-Recognition Patterns of Intrinsically Disordered Proteins.
AB  - Intrinsically disordered regions (IDRs) and protein (IDPs) are highly flexible
      owing to their lack of well-defined structures. A subset of such proteins
      interacts with various substrates; including RNA; frequently adopting regular
      structures in the final complex. In this work; we have analysed a dataset of
      protein-RNA complexes undergoing disorder-to-order transition (DOT) upon binding.
      We found that DOT regions are generally small in size (less than 3 residues) for
      RNA binding proteins. Like structured proteins; positively charged residues are
      found to interact with RNA molecules; indicating the dominance of electrostatic
      and cation-pi interactions. However, a comparison of binding frequency shows that
      interface hydrophobic and aromatic residues have more interactions in only DOT
      regions than in a protein. Further; DOT regions have significantly higher
      exposure to water than their structured counterparts. Interactions of DOT regions
      with RNA increase the sheet formation with minor changes in helix forming
      residues. We have computed the interaction energy for amino acids-nucleotide
      pairs; which showed the preference of His-G; Asn-U and Ser-U at for the interface
      of DOT regions. This study provides insights to understand protein-RNA
      interactions and the results could also be used for developing a tool for
      identifying DOT regions in RNA binding proteins.

PMID- 29843483
TI  - Minimally Invasive Limited Ligation Endoluminal-Assisted Revision (MILLER): A
      Review of the Available Literature and Brief Overview of Alternate Therapies in
      Dialysis Associated Steal Syndrome.
AB  - Dialysis associated steal syndrome (DASS) is a relatively rare but debilitating
      complication of arteriovenous fistulas. While mild symptoms can be observed, if
      severe symptoms are left untreated, DASS can result in ulcerations and limb
      threatening ischemia. High-flow with resultant heart failure is another
      documented complication following dialysis access procedures. Historically, open
      surgical procedures have been the mainstay of therapy for both DASS as well as
      high-flow. These procedures included ligation, open surgical banding, distal
      revascularization-interval ligation, revascularization using distal inflow, and
      proximal invasion of arterial inflow. While effective, open surgical procedures
      and general anesthesia are preferably avoided in this high-risk population.
      Minimally invasive limited ligation endoluminal-assisted revision (MILLER) offers
      both a precise as well as a minimally invasive approach to treating both dialysis
      associated steal syndrome as well as high-flow with resultant heart failure.
      MILLER is not ideal for all DASS patients, particularly those with low-flow
      fistulas. We aim to briefly describe the open surgical therapies as well as
      review both the technical aspects of the MILLER procedure and the available
      literature.

PMID- 29843484
TI  - Cellular Aging and Death.

PMID- 29843485
TI  - Expression and Introduction of Macromolecules into Cells.

PMID- 29843486
TI  - Microscopy.

PMID- 29843488
TI  - Fluorescent Protein Technology.

PMID- 29843487
TI  - Organelle Motility.

PMID- 29843490
TI  - In Vitro Reconstitution.

PMID- 29843489
TI  - Protein Trafficking.

PMID- 29843492
TI  - Comparison of antiplatelet treatment in patients with clopidogrel nonresponders
      with or without carriage of CYP2C19 polymorphism.
AB  - Background/Aims: Several interventions exist for overcoming high platelet
      reactivity (HPR) on clopidogrel therapy. The goal of this study was to identify
      strategies that improve inhibition of platelet reactivity in clopidogrel
      nonresponders with or without loss of function CYP2C19 genotypes, resulting in
      platelet reactivity similar to that in responders. Methods: A total of 376
      patients with stenting for coronary artery disease underwent platelet function
      testing in three centers. Blinded platelet function tests were performed after 75
      mg daily clopidogrel treatment for 28 days. In total, 183 nonresponders were
      genotyped, were randomized to four treatment groups with each treatment lasting
      approximately 28 days, and underwent repeated measurements of platelet reactivity
      after treatment. Results: With 75 mg of daily clopidogrel, nonresponders had
      significantly higher HPR than did responders (multiple electrode aggregometry
      [MEA, arbitrary platelet aggregation unit]: mean, 71.4; 95% confidence intervals
      [CI], 68.6 to 74.3; and mean, 27.5; 95% CI, 26.0 to 28.9, respectively; p <
      0.001). Ticagrelor or ticlopidine treatment in nonresponders resulted in platelet
      reactivity similar to that in responders in intermediate metabolizers (mean,
      24.0; 95% CI, 19.6 to 28.4; p > 0.05; and mean, 30.0; 95% CI, 24.7 to 37.5; p >
      0.05, respectively) and poor metabolizers (mean, 23.2; 95% CI, 18.0 to 28.3; p >
      0.05; and mean, 30.3; 95% CI, 24.5 to 6.0; p > 0.05, respectively). However, in
      extensive metabolizers, only ticagrelor treatment showed platelet reactivity
      similar to that in responders (mean, 26.1; 95% CI, 24.1 to 28.0; p > 0.05).
      Conclusions: Among clopidogrel nonresponders with cardiovascular disease on 75 mg
      daily clopidogrel, ticagrelor resulted in a comparable degree of platelet
      inhibition in all nonresponders compared with 150 mg daily clopidogrel or triple
      therapy with clopidogrel and cilostazol, irrespective of phenotype.

PMID- 29843491
TI  - Clinical significance of Th17 cells in kidney transplantation.
AB  - Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell
      targeted strategies, but little attention has been paid to the role of T helper
      17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests
      that Th17 cells contribute to the development of acute and chronic allograft
      injury after transplantation of various organs, including the kidney. This review
      summarizes recent reports on the role of Th17 cells in kidney transplantation.
      Means of improving allograft outcomes by targeting the Th17 pathway are also
      suggested.

PMID- 29843493
TI  - Surrogate decision making of chemotherapy consent: do we really provide informed
      consent of chemotherapy for patients?
AB  - Background/Aims: Despite increased demand for cancer patient's to make their own
      decisions based on an adequate understanding of what is involved in chemotherapy,
      the primary signing agent and the reasons for surrogate signing have not been
      appropriately evaluated. Methods: The ethics committee of the palliative medicine
      subgroup of the Korean Cancer Study Group designed this study and solid cancer
      patients to whom chemotherapy was offered, from seven institutions, were
      evaluated. The details relating to surrogate's signing of chemotherapy consent
      were evaluated. Then, we analyzed the factors associated with surrogate's signing
      according to patient's demographics and characteristics related to chemotherapy
      consent. Results: Surrogate's signing was noted for 20.7% (84/405) of patient and
      over half of surrogate signings were performed by the patients' son or daughter
      (60.7%). Two main reasons for surrogate signing were patient's incapacity (34.5%)
      and taking over authorization from patients (33.3%). The factors associated with
      more frequent surrogate's signing were absence of spouse, lower education level,
      outpatient, and when residents played a role as a principle provider of
      chemotherapy consent. Conclusions: This study suggests the lack of patients' own
      decision making for chemotherapy in some situations. This ethical dilemma must be
      considered for adequately informed decision making for chemotherapy while
      ensuring the patients' autonomy is maintained.

PMID- 29843494
TI  - Prolonged low-dose cyclophosphamide treatment after pulse therapy attenuates lung
      injury in rats with paraquat intoxication.
AB  - BACKGROUND/AIMS: This study tested the hypothesis that prolonged low-dose
      cyclophosphamide (CTX) treatment after pulse therapy attenuate paraquat (PQ)
      induced lung injury in rats. METHODS: PQ (25 mg/kg) was administered
      intraperitoneally to induce PQ-intoxicated rat model. The rats were randomly
      divided into four groups: control group (1 mL/day saline solution for 14 days),
      PQ group (1 mL/day saline solution for 14 days after PQ exposure), pulse group
      (15 mg/kg/day CTX in 1 mL of saline solution for 2 days and subsequent 1 mL/day
      saline solution for 12 days), and prolonged low-dose group (15 mg/kg/day CTX in 1
      mL of saline solution for 2 days and subsequent 1.5 mg/kg/day CTX in 1 mL of
      saline solution for 12 days). A 14-day follow-up was conducted to determine the
      survival rat, and lung hydroxyproline (HYP), wet-to-dry weight ratios (W/Dc) and
      histopathological changes were evaluated. RESULTS: Results showed similar
      survival rate (55% vs. 50%, p > 0.05) between prolonged low-dose and pulse
      groups. Lung W/Dc (4.94 +/- 0.38 vs. 5.47 +/- 0.28, p < 0.01), HYP (3.34 +/- 0.29
      ug/mg vs. 3.65 +/- 0.19 ug/mg, p < 0.001), and fibrosis score (2.69 +/- 0.84 vs.
      3.13 +/- 0.63, p < 0.05) were lower in prolonged low-dose group than those in the
      pulse group. CONCLUSION: These findings suggested prolonged low-dose CTX
      treatment after pulse therapy could attenuate PQ-induced lung injury in rats.

PMID- 29843495
TI  - Age at menarche and risk of colorectal adenoma.
AB  - Background/Aims: Limited data are available regarding the association between age
      at menarche and the risk of colorectal adenoma. Therefore, we aimed to evaluate
      the relationship between reproductive factors including age at menarche and the
      risk of colorectal adenoma. Methods: A cross-sectional study was performed on
      asymptomatic female subjects who underwent colonoscopy between 2010 and 2014 as
      part of a comprehensive health screening program in Korea. The association
      between reproductive factors including age at menarche and the presence of
      adenomas was assessed using multivariate logistic regression analysis. Results:
      Among 32,620 asymptomatic female subjects, the proportion of patients with
      menarche at 10 to 11, 12 to 13, 14 to 15, 16 to 17, and 18 to 19 years of age was
      4.1%, 31.7%, 45.4%, 14.9%, and 4.0%, respectively. Age at menarche was not
      significantly associated with the risk of any adenoma (adjusted odds ratio [AOR],
      0.99; 95% confidence interval [CI], 0.97 to 1.02; p = 0.500) or advanced adenoma
      (AOR, 0.98; 95% CI, 0.91 to 1.04; p = 0.468) after adjusting for confounding
      factors. Age at menarche was not significantly associated with the risk of
      adenoma even among similar age groups. In addition, parity, use of female
      hormones, and menopause were not associated with the risk of adenoma.
      Conclusions: Age at menarche, parity, use of female hormones, and menopause were
      not significantly associated with the risk of colorectal adenoma. Our findings
      indicate that reproductive factors including age at menarche do not affect the
      development of colorectal adenoma.

PMID- 29843496
TI  - Validity and Reliability of the Turkish Chronic Pain Acceptance Questionnaire
AB  - Background: Pain acceptance is the process of giving up the struggle with pain
      and learning to live a worthwhile life despite it. In assessing patients with
      chronic pain in Turkey, making a diagnosis and tracking the effectiveness of
      treatment is done with scales that have been translated into Turkish. However,
      there is as yet no valid and reliable scale in Turkish to assess the acceptance
      of pain. Aims: To validate a Turkish version of the Chronic Pain Acceptance
      Questionnaire developed by McCracken and colleagues. Study Design: Methodological
      and cross sectional study. Methods: A simple randomized sampling method was used
      in selecting the study sample. The sample was composed of 201 patients, more than
      10 times the number of items examined for validity and reliability in the study,
      which totaled 20. A patient identification form, the Chronic Pain Acceptance
      Questionnaire, and the Brief Pain Inventory were used to collect data. Data were
      collected by face-to-face interviews. In the validity testing, the content
      validity index was used to evaluate linguistic equivalence, content validity,
      construct validity, and expert views. In reliability testing of the scale,
      Cronbach's alpha coefficient was calculated, and item analysis and split-test
      reliability methods were used. Principal component analysis and varimax rotation
      were used in factor analysis and to examine factor structure for construct
      concept validity. Results: The item analysis established that the scale, all
      items, and item-total correlations were satisfactory. The mean total score of the
      scale was 21.78. The internal consistency coefficient was 0.94, and the
      correlation between the two halves of the scale was 0.89. Conclusion: The Chronic
      Pain Acceptance Questionnaire, which is intended to be used in Turkey upon
      confirmation of its validity and reliability, is an evaluation instrument with
      sufficient validity and reliability, and it can be reliably used to examine
      patients' acceptance of chronic pain.

PMID- 29843497
TI  - Rare Fibroepithelial Polyp Extending Along the Ureter: A Case Report
AB  - Background: Fibroepithelial polyps of the urinary tract are rare tumors, and
      their occurrence in the upper urinary tract is highly unusual. Case Report: This
      study reports a 9-year-old boy who presented to our clinic with complaints of
      unilateral flank pain and macroscopic hematuria. The direct urinary system graph
      did not show stone formation; therefore, magnetic resonance urography was
      performed. This revealed a filling defect in the left proximal ureter. On
      cystoscopy, a polyp was seen in the orifice of the left ureter, extending along
      the ureter. The polyp was resected by laser ablation and removed from the ureter.
      Histopathologic examination revealed a fibroepithelial polyp comprising
      fibrovascular stroma covered with transitional epithelium. Conclusion: Although
      extremely rare, a fibroepithelial polyp should be considered in the differential
      diagnosis when a young patient presents with flank pain and macroscopic
      hematuria. Endoscopic procedures may be the treatment of choice for polyps
      located in the upper ureter.

PMID- 29843498
TI  - Successful Management of Aggressive Fibromatosis of the Neck: A Case Report
AB  - Background: Aggressive fibromatoses are histologically benign fibrous neoplasms
      originating from musculoaponeurotic structures throughout the body. They are
      locally invasive and erode adjacent vital structures. The head and neck region
      constitutes 7-25% of all extra-abdominal cases. Case Report: Here, we report the
      case of a patient with aggressive fibromatosis in the left side of the neck.
      While the tumor deeply invaded the scalene muscles, the lesion was successfully
      treated by surgery followed by radiotherapy. The patient has been disease free
      for the last 7 years following treatment. Conclusion: Due to its unusual location
      in the head and neck region, aggressive fibromatosis should be considered in the
      differential diagnosis of invading lesions of the neck.

PMID- 29843499
TI  - Endoscopic treatment of early esophageal squamous neoplasia.
AB  - Esophageal squamous cell carcinoma (ESCC) remains the most common esophageal
      cancer in the world, though a rising incidence of esophageal adenocarcinoma could
      be seen during the last decade in the western world. There are several known risk
      factors for ESCC, such as smoking, alcohol consumption, radiation or others. As
      there is a risk of lymph node metastasis already in early stages, early
      endoscopic detection is crucial for curative endoscopic treatment options.
      Therefore, newest technical improvements such as enhancement techniques or
      virtual chromoendoscopy are helpful for the diagnosis of mucosal carcinoma.
      Lugol's iodine remains the gold standard to detect early esophageal cancer,
      however, it should be combined with these newer techniques. For the prediction of
      invasion depth, a new classification was developed by the Japan Esophageal
      society. By using magnifying endoscopy and Narrow Band Imaging, the microvascular
      morphology allows a prediction of invasion depth of early squamous cell
      carcinoma. Endoscopic resection is suitable for patients with early-stage ESCC
      (m1-m2), because of the low risk of lymph node metastasis. EMR should be
      performed if the lesion is smaller than 15 mm, because a R0 resection can be
      achieved. Larger lesions (>15 mm) should be resected via endoscopic submucosal
      dissection to reach an en bloc resection, a lower recurrence rate and a R0
      situation.

PMID- 29843500
TI  - Percutaneous catheter drainage combined with peritoneal dialysis for treating
      acute severe pancreatitis: a single-center prospective study.
AB  - BACKGROUND: To investigate the efficacy of percutaneous catheter drainage (PCD)
      and peritoneal dialysis (PD) in the treatment of severe acute pancreatitis (SAP)
      and its underlying mechanism. METHODS: Totally 64 SAP patients were included in
      our study and randomly assigned into PCD + PD group (the combination group, N =
      32) and convention group (N = 32). SAP patients in the combination group were
      treated with percutaneous catheter drainage combined with peritoneal dialysis,
      while those in the convention group were treated with conventional method. The
      treatment efficacy of both methods were evaluated by comparing levels of plasma
      inflammatory cytokines (IL-6, IL-8, TNF-alpha, C-reactive protein, procalcitonin
      and leukocyte count), relative indexes of important organs (aspartate
      aminotransferase, alanine aminotransferase, creatinine and urea nitrogen) and
      other clinical data (amelioration time of abdominal pain and abdominal
      distension, Balthazar CT scores, acute physiology and chronic health enquiry II
      score, length of hospital stay, complications and prognosis). RESULTS: The
      expression levels of inflammatory cytokines were significantly decreased in the
      combination group in a time-dependent manner in comparison with those of the
      convention group. In addition, the amelioration time of abdominal pain and
      abdominal distension, length of hospital stay, Balthazar CT scores and the acute
      physiology and chronic health care II scores in the combination group were also
      significantly decreased in comparison with those of the convention group.
      CONCLUSIONS: The combination treatment of PCD and PD effectively relieves the
      clinical symptoms of SAP by clearing plasma inflammatory cytokines.

PMID- 29843501
TI  - Surgical technique in robotic right colonic resection.
AB  - Minimally invasive surgery (MIS) has produced an important improvement in terms
      of peri-operative outcomes. Laparoscopic colorectal surgery presents comparable
      outcomes vs open approach from an oncological standpoint. However, there are some
      technical challenges/hurdles that laparoscopy may have. Worldwide there are still
      too many colonic/rectal operations carried out by the open approach. The robotic
      technology may be useful in solving some of the potential laparoscopic issues and
      potentially it may increase the number of procedures performed in a minimally
      invasive way. This is a description of our standardized operative technique for
      Robotic Right Colonic Resection. Conceivably, this manuscript may be useful to
      collect more repeatable data in the future. Moreover, it might be a guide to
      learn the robotic technique and also for the expert surgeons as an additional
      tool which they may find useful during their teaching activity. In this
      manuscript, taking advantage of the long and extensive expertise in minimally
      invasive colorectal resections, connected to a robotic experience started by
      Giulianotti et al1 in October 2000, we present our standardized technique for the
      robotic right colonic resection. The currently available literature data have
      proven that robotic colorectal surgery is safe/feasible. From the literature
      data, and from our experience as well, we think that these are the following main
      points: 1) The right colectomy is often an operation which can be performed in a
      relatively simple way even with traditional laparoscopy. However, the robotic
      approach is easier to standardize and this operation is very useful from a
      teaching standpoint in order to master multiple robotic surgical skills (that can
      be applied in more complex colorectal operations); 2) The robotic surgery may
      increase the MIS penetrance in this field. 3) The robotic third arm (R3) is an
      important technical advantage which can potentially increase the range of
      surgical options available; 4) The robotic technology is relatively recent. Most
      of the available data are retrospective and there is literature heterogenity
      (this affects also the conclusions of the currently available meta-analysis
      results, which sometimes are conflicting); 5) We need more data from prospective
      randomized well-powered studies (with standardized technique). Achieving a
      standardized technical approach will be essential in robotic colorectal surgery.

PMID- 29843502
TI  - Multiple Loops of External and Internal Carotid Arteries Vulnerable in Surgical
      and Radiological Procedures

PMID- 29843503
TI  - Amlodipine toxicity and lipid emulsion.

PMID- 29843504
TI  - Initial experience with the unrestricted introduction of sugammadex at a large
      academic medical center: a retrospective observational study examining
      postoperative mechanical ventilation and efficiency outcomes.
AB  - BACKGROUND: Sugammadex rapidly reverses deep neuromuscular blockade, but owing to
      cost, questions remain about its optimal utilization. After the unrestricted
      introduction of sugammadex at Emory University Hospital, we hypothesized that
      reductions would be demonstrated in the primary outcome of post-anesthesia care
      unit (PACU) mechanical ventilation (MV) and secondary outcomes of PACU length of
      stay (LOS) and emergence time (surgery end to anesthesia end time in the PACU).
      METHODS: This retrospective observational study included patients undergoing
      general anesthesia over a 12-month period. Using multiple variable penalized
      logistic regression in a one-group before-and-after design, we compared the
      categorized rates of PACU MV to examine the effect of sugammadex introduction
      following a post-hoc chart review to ascertain the reason for postoperative MV.
      Additionally, multiple variable linear regression was used to assess for
      differences in PACU LOS and emergence time within a propensity-matched set of
      patients receiving neostigmine or sugammadex. RESULTS: In total, 7,217 surgical
      cases met the inclusion criteria: 3,798 before and 3,419 after sugammadex
      introduction. The incidence of PACU MV was 2.3% before and 1.8% after (P = 0.118)
      sugammadex introduction. PACU MV due to residual neuromuscular blockade (rNMB)
      decreased from 0.63% to 0.20% (P = 0.005). Ventilation because of other causes
      was unchanged. PACU LOS and emergence time were unchanged in the propensity
      matched set of 1,444 patients. CONCLUSIONS: rNMB was an important contributor to
      PACU MV utilization and its incidence significantly decreased after sugammadex
      introduction. The selected efficiency measures may not have been sufficiently
      granular to identify improvements following introduction.

PMID- 29843505
TI  - Significance of outer diameter of endotracheal tube: a parameter less known.

PMID- 29843506
TI  - A bench study comparing between scalpel-bougie technique and cannula-to-Melker
      technique in emergency cricothyroidotomy in a porcine model.
AB  - BACKGROUND: The ideal emergency cricothyroidotomy technique remains a topic of
      ongoing debate. This study aimed to compare the cannula-to-Melker technique with
      the scalpel-bougie technique and determine whether yearly training in
      cricothyroidotomy techniques is sufficient for skill retention. METHODS: We
      conducted an observational crossover bench study to compare the cannula-to-Melker
      with the scalpel-bougie technique in a porcine tracheal model. Twenty-eight
      anesthetists participated. The primary outcome was time taken for device
      insertion. Secondary outcomes were first-pass success rate, incidence of tracheal
      trauma, and technique preference. We also compared the data on outcome measures
      with the data obtained in a similar workshop a year ago. RESULTS: The scalpel
      bougie technique was significantly faster than the cannula-to-Melker technique
      for cricothyroidotomy (median time of 45.2 s vs. 101.3 s; P = 0.001). Both
      techniques had 100% success rate within two attempts; there were no significant
      differences in the first-pass success rates and incidence of tracheal wall trauma
      (P > 0.999 and P = 0.727, respectively) between them. The relative risks of
      inflicting tracheal wall trauma after a failed cricothyroidotomy attempt were 6.9
      (95% CI 1.5-31.1), 2.3 (95% CI 0.3-20.7) and 3.0 (95% CI 0.3-25.9) for the
      scalpel-bougie, cannula-cricothyroidotomy, and Melker-Seldinger airway,
      respectively. The insertion time and incidence of tracheal wall trauma were lower
      when the present data were compared with data from a similar workshop conducted
      the previous year. CONCLUSIONS: This study supports the use of a scalpel-bougie
      technique for cricothyroidotomy by anesthetists and advocates a yearly training
      program for skill retention.

PMID- 29843507
TI  - Evaluation of efficacy of Valsalva maneuver for attenuating propofol injection
      pain: a prospective, randomized, single blind, placebo controlled study.
AB  - BACKGROUND: Pain on injection is a limitation with propofol use. The effect of
      the Valsalva maneuver on pain during propofol injection has not been studied.
      This maneuver reduces pain through the sinoaortic baroreceptor reflex arc and by
      distraction. We aimed to assess the efficacy of the Valsalva maneuver in reducing
      pain during propofol injection. METHODS: Eighty American Society of
      Anesthesiologists class I adult patients undergoing general anesthesia were
      enrolled and divided into two groups of 40 each. Group I (Valsalva) patients blew
      into a sphygmomanometer tube raising the mercury column up to 30 mmHg for 20
      seconds, while Group II (Control) patients did not. Anesthesia was induced with
      1% propofol immediately afterwards. Pain was assessed on a 10-point visual analog
      scale (VAS), where 0 represented no pain, and 10, the worst imaginable pain, and
      a 4-point withdrawal response score, where 0 represented no pain, and 3, the
      worst imaginable pain. Scores were presented as median (interquartile range).
      RESULTS: We analyzed the data of 70 patients. The incidence of pain was
      significantly lower in the Valsalva than in the control group (53% vs. 78%, P =
      0.029). The withdrawal response score was significantly lower in the Valsalva
      group (1.00 [0.00-1.00] vs. 2.00 [2.00-3.00], P < 0.001). The VAS score was
      significantly lower in the Valsalva group (1.00 [0.00-4.00] vs. 7.00 [6.25-8.00],
      P < 0.001). CONCLUSIONS: A prior Valsalva maneuver is effective in attenuating
      injection pain due to propofol; it is advantageous in being a non
      pharmacological, safe, easy, and time-effective technique.

PMID- 29843508
TI  - Dexmedetomidine and propofol sedation requirements in an autistic rat model.
AB  - Background: Autism is a challenging neurodevelopmental disorder. Previous
      clinical observations suggest altered sedation requirements for autistic
      children. Our study aimed to test this observation experimentally with an animal
      model and, to explore its possible mechanisms. Methods: Eight adult pregnant
      female Sprague Dawley rats were randomly selected into two groups. Four were
      injected with intraperitoneal sodium valproate on the gestational day 12 and four
      were injected with normal saline. On post-natal day 28 the newborn male rats were
      subjected to an open field test to confirm autistic features. Each rat was
      injected intraperitoneally with a single dose of propofol (50 mg/kg) or
      dexmedetomidine (0.2 mg/kg). Times to Loss of Righting Reflex (LORR) and to
      Return of Righting Reflex (RORR) were recorded. On the next day, all rats were re
      sedated and their EEGs were recorded. The rats were sacrificed and hippocampal
      GABAA and glutamate NMDA receptor gene expression were assessed. Results:
      Autistic rats showed significantly longer time to LORR and a shorter time to RORR
      compared to controls (Median time to LORR: 12.0 versus 5.0 for dexmedetomidine
      and 22.0 and 8.0 for propofol; p < 0.05). EEG showed a low frequency, high
      amplitude wave pattern two minutes after LORR in control rats. Autistic rats
      showed a high frequency, low amplitude awake pattern. Hippocampal GABAA receptor
      gene expression was significantly less in autistic rats and NMDA gene expression
      was greater. Conclusions: This study in rat supports the clinical observations of
      increased anesthetic sedative requirements in autistic children and proposes a
      mechanism for it.

PMID- 29843509
TI  - Aprepitant in combination with palonosetron for the prevention of postoperative
      nausea and vomiting in female patients using intravenous patient-controlled
      analgesia.
AB  - BACKGROUND: The aim of this study was to evaluate aprepitant in combination with
      palonosetron as compared to palonosetron alone for the prevention of
      postoperative nausea and vomiting (PONV) in female patients receiving fentanyl-
      based intravenous patient-controlled analgesia (IV-PCA). METHODS: In this
      randomized single-blinded study, 100 female patients scheduled for elective
      surgery under general anesthesia were randomized to two groups: Group AP (80 mg
      aprepitant plus 0.075 mg palonosetron, n = 50) and Group P (0.075 mg
      palonosetron, n = 50). The patients in group AP received 80 mg aprepitant per
      oral 1-3 h before surgery, while all patients received 0.075 mg palonosetron
      after induction of standardized anesthesia. All patients had postoperative access
      to fentanyl-based IV-PCA. The incidence of nausea and vomiting, use of rescue
      medication, and severity of nausea were evaluated at 6 and 24 h after surgery.
      RESULTS: The incidence of nausea (54%) and vomiting (2%) in group AP did not
      differ significantly from that in group P (48% and 14%, respectively) during the
      first 24 h after surgery (P > 0.05). Patient requirements for rescue medication
      in group AP (29%) were similar to those in group P (32%) at 24 h after surgery (P
      > 0.05). There was no difference between the groups in severity of nausea during
      the first 24 h after surgery (P > 0.05). CONCLUSIONS: Aprepitant combined with
      palonosetron did not reduce the incidence of PONV as compared to palonosetron
      alone within 24 h of surgery in women receiving fentanyl-based IV-PCA.

PMID- 29843510
TI  - Author Correction: MRI Vessel Wall Imaging and Treatment of an Aneurysm at the
      Atlanto-Axial Segment of an Aberrant Vertebral Artery.

PMID- 29843511
TI  - Author Correction: Treatment of Intracranial Aneurysms with the Pipeline
      Embolization Device Only: a Single Center Experience.

PMID- 29843513
TI  - Collisional Excitation and Weak Maser Action of Interstellar Methanimine.
AB  - The inelastic cross sections and rate coefficients for the rotational excitation
      of methanimine (CH2NH) by cold H2 have been determined quantum mechanically based
      on a new highly correlated five-dimensional potential energy surface. This
      surface was fitted to more than 60 000 ab initio points with a root-mean-square
      error of ~1-2 cm-1 in the region of the potential well whose depth is -374.0 cm
      1. The rotationally inelastic rate coefficients have been combined with
      spectroscopic data to generate the nonequilibrium spectrum of CH2NH toward the
      interstellar molecular cloud Sgr B2(N). The transition 110 -> 111 at 5.29 GHz is
      found to be inverted, and the predicted weak maser emission spectrum is in
      excellent agreement with new observations performed with the 100 m Green Bank
      Telescope.

PMID- 29843512
TI  - Dissociative Chemisorption of O2 on Al(111): Dynamics on a Correlated Wave
      Function-Based Potential Energy Surface.
AB  - Dissociative chemisorption of O2 on the Al(111) surface represents an extensively
      studied prototype for understanding the interaction between O2 and metal
      surfaces. It is well known that the experimentally observed activation barrier
      for O2 dissociation is not captured by conventional density functional theory.
      The interpretation of this barrier as a result of spin transitions along the
      reaction path has been challenged by recent embedded correlated wave function
      (ECW) calculations that naturally yield an adiabatic barrier. However, the ECW
      calculations have been limited to a static analysis of the reaction pathways and
      have not yet been tested by dynamics simulations. We present a global six
      dimensional potential energy surface (PES) for this system parametrized with ECW
      data points. This new PES provides a reasonable description of the site-specific
      and orientation-dependent activation barriers. Quasi-classical trajectory
      calculations on this PES semiquantitatively reproduce both the observed
      translational energy dependence of the sticking probability and steric effects
      with aligned O2 molecules.

PMID- 29843514
TI  - 10beta,17alpha-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug
      Preferentially Producing 17alpha-Estradiol in the Brain for Targeted
      Neurotherapy.
AB  - Uterotrophic effect of 17alpha-estradiol, the C17 epimer of the main human
      estrogen 17beta-estradiol, was shown to manifest in animal models at doses lower
      than those necessary for central outcome raising concerns about its potential to
      treat maladies of the central nervous system. We introduce here 10beta,17alpha
      dihydroxyestra-1,4-dien-3-one (alpha-DHED) that acts as a bioprecursor prodrug
      producing 17alpha-estradiol with remarkable selectivity to the brain and,
      therefore, without appreciable exposure of the periphery to the parent steroid.
      This distinguishing feature of alpha-DHED is shown by using an estrogen
      responsive mouse model with complementary LC-MS/MS measurement of drug contents
      in target tissues. Our data warrant further research to fully establish the
      potential of alpha-DHED for a safe and efficacious 17alpha-estradiol-based
      neurotherapy.

PMID- 29843516
TI  - Risk factors associated with gastric cancer in Mexico: education, breakfast and
      chili.
AB  - BACKGROUND AND AIM: the aim of the study was to use a validated questionnaire to
      identify factors associated with the development of gastric cancer (GC) in the
      Mexican population. METHODS: the study included cases and controls that were
      paired by sex and +/- 10 years of age at diagnosis. In relation to cases, 46
      patients with a confirmed histopathological diagnosis of adenocarcinoma-type GC,
      as reported in the hospital records, were selected, and 46 blood bank donors from
      the same hospital were included as controls. The previously validated
      Questionnaire to Find Factors Associated with Gastric Cancer (QUFA-GC(c)) was
      used to collect data. Odds ratio (OR) and 95% confidence interval (IC) were
      estimated via univariate analysis (paired OR). Multivariate analysis was
      performed by logistic regression. A decision tree was constructed using the J48
      algorithm. RESULTS: an association was found by univariate analysis between GC
      risk and a lack of formal education, having smoked for >= 10 years, eating
      rapidly, consuming very hot food and drinks, a non-suitable breakfast within two
      hours of waking, pickled food and capsaicin. In contrast, a protective
      association against GC was found with taking recreational exercise and consuming
      fresh fruit and vegetables. No association was found between the development of
      GC and having an income that reflected poverty, using a refrigerator, perception
      of the omission of breakfast and time period of alcoholism. In the final
      multivariate analysis model, having no formal education (OR = 17.47, 95% CI =
      5.17-76.69), consuming a non-suitable breakfast within two hours of waking (OR =
      8.99, 95% CI = 2.85-35.50) and the consumption of capsaicin ? 29.9 mg capsaicin
      per day (OR = 3.77, 95% CI = 1.21-13.11) were factors associated with GC.
      CONCLUSIONS: an association was found by multivariate analysis between the
      presence of GC and education, type of breakfast and the consumption of capsaicin.
      These variables are susceptible to intervention and can be identified via the
      QUFA-GC

PMID- 29843517
TI  - Determining the feasibility and preliminary efficacy of a stroke instructional
      and educational DVD in a multinational context: a randomized controlled pilot
      study.
AB  - OBJECTIVE: To assess the feasibility of conducting a randomized controlled trial
      of an instructional and educational stroke DVD and determine the feasibility and
      preliminary efficacy of this intervention in a multinational context. DESIGN: Non
      funded, pilot randomized controlled trial of intervention versus usual care.
      SETTING: International, multicentre, community-based. PARTICIPANTS: Community
      living adults up to three years post stroke with moderate to severe disability
      and their nominated informal caregivers. INTERVENTIONS: Intervention patients
      viewed and practised rehabilitation techniques demonstrated in the DVD over six
      weeks. MAIN MEASURES: Trial feasibility by number of active recruitment sites,
      recruitment efficiency, randomization and follow-up. Intervention feasibility by
      patient and caregiver impressions. Preliminary efficacy by the quality of life -
      5-level EuroQol-5D (EQ-5D) health status measure, General Health Questionnaire
      and Centre for Epidemiological Studies-Depression at two months. RESULTS: In
      total, 14 recruitment sites were established across eight countries. Recruitment
      was achieved at nine (64%) sites. Over 16 months, 66 participants were recruited
      (mean (SD) age = 63.5 (12.47) years) and randomized to intervention ( n = 34) and
      control ( n = 32) groups. In total, 54 (82%) completed a follow-up assessment.
      Patient and/or caregiver comments about the benefits and barriers to accessing
      the intervention were mixed. There were no significant between-group differences
      in outcomes at two months ( P > 0.05). CONCLUSION: Conducting a multinational
      trial of a stroke DVD requires full funding. The intervention was acceptable to
      some patients and their caregivers, yet a generalized education approach did not
      fully meet their needs and/or expectations. A more individualized method may be
      required to meet peoples' changing needs during stroke recovery.

PMID- 29843518
TI  - Correlates of viral suppression among HIV-infected men who have sex with men and
      transgender women in Lima, Peru.
AB  - In Peru, HIV is concentrated among men who have sex with men (MSM) and
      transgender women (TGW). Between June 2015 and August 2016, 591 HIV-positive MSM
      and TGW were recruited at five clinical care sites in Lima, Peru. We found that
      82.4% of the participants had achieved viral suppression (VS; VL < 200) and 73.6%
      had achieved maximal viral suppression (MVS; VL < 50). Multivariable modeling
      indicated that patients reporting transportation as a barrier to HIV care were
      less likely to achieve VS (aOR = 0.47; 95% CI = 0.30-0.75) and MVS (aOR = 0.56;
      95% CI = 0.37-0.84). Alcohol use disorders were negatively associated with MVS
      (aOR = 0.62; 95% CI = 0.30-0.75) and age was positively associated with achieving
      MVS (aOR = 1.29; 95% CI = 1.04-1.59). These findings underscore the need for more
      accessible HIV care with integrated behavioral health services in Lima, Peru.

PMID- 29843519
TI  - Experience and Views of Oncology and Palliative Care Professionals on a
      Corounding Model of Care for Inpatients With Advanced Cancer.
AB  - BACKGROUND: Palliative care is associated with better outcomes in advanced
      cancer, but there is limited research comparing different models of palliative
      care delivery alongside oncology care. For inpatients with cancer, palliative
      care is mostly delivered through a consult service, primarily relying on
      oncologist-initiated referrals to a separate specialist palliative care team. In
      our hospital setting, we piloted a palliative care and oncology corounding model
      of care. AIM: To explore the views and experience of oncology and palliative care
      professionals on the corounding model compared to an inpatient consult service.
      DESIGN: A qualitative study nested within a pre-post study of the corounding
      model of care, with semistructured interviews using thematic analysis.
      SETTING/PARTICIPANTS: Eleven doctors and nurses involved in the pilot corounding
      model were interviewed. RESULTS: Two main themes emerged: (1) the efficiency of
      care delivery and (2) quality of patient care. The theme on the efficiency of
      care delivery was related to access to palliative care input, team
      communications, and parallel workflow. The quality of patient care was described
      in terms of holistic approach to cancer care and rapport building with patients
      and their families. Most participants acknowledged positive aspects of the
      corounding model, yet some minor concerns were reported, such as disagreements
      between oncology and palliative care professionals. CONCLUSIONS: This study
      provides insights into the benefits and drawbacks of a corounding model of care
      for inpatients. The views of health-care professionals can be incorporated into
      the development of integrated oncology and palliative care models to improve care
      for patients with advanced cancer.

PMID- 29843520
TI  - Effectiveness of mobilization with movement (Mulligan concept techniques) on low
      back pain: a systematic review.
AB  - OBJECTIVE: To evaluate evidence on the effectiveness of Mulligan techniques on
      low back pain. DATA SOURCES: PubMed/Medline, Scopus, Ovid, CINAHL, Embase, PEDro,
      Google Scholar, and Cochrane Library were searched from inception to 31 March
      2018 for randomized clinical trials reporting outcomes of pain or disability in
      adult patients (?18 years) with low back pain. REVIEW METHODS: Two authors
      screened the results and extracted data for use in this review. The risk of bias
      was evaluated using the Cochrane criteria. Basic information and treatment
      protocols were also extracted. In addition, the level of evidence of each study
      and strength of conclusion for pain and disability were determined. RESULTS: A
      total of 20 studies with 693 patients were included. Nine trials focused on
      sustained natural apophyseal glide, three on spinal mobilization with limb
      movement and seven on bent leg raise. The results showed that Mulligan techniques
      can decrease pain and disability and increase range of motion in patients with
      low back pain; however, the strength of conclusion for pain and disability was
      moderate. Furthermore, inconclusive results were observed for the effectiveness
      of Mulligan techniques on movement speed. In this review, eight studies were
      categorized as low risk of bias, while 12 studies had high risk of bias. Level of
      evidence analysis revealed that 17 studies were classified as level of evidence
      B, while three studies were classified as level of evidence A2. CONCLUSION:
      Current evidence is insufficient in supporting the benefits of Mulligan
      techniques on pain, disability, and range of motion in low back pain patients.

PMID- 29843521
TI  - Responsiveness of five measures of arm function in acute stroke rehabilitation.
AB  - OBJECTIVE: To determine the responsiveness of five arm function measures in
      people receiving acute inpatient stroke rehabilitation. DESIGN: Inception cohort
      study. SETTING: Comprehensive stroke unit providing early rehabilitation.
      SUBJECTS: A total of 64 consecutively admitted stroke survivors with moderately
      severe disability (Modified Rankin Scale score median (interquartile range
      (IQR)): 4.0 (1.0)). MAIN MEASURES: Responsiveness was analyzed by calculating
      effect size, standardized response mean and median-based effect size.
      Floor/ceiling effects were calculated as the percentage of participants scoring
      the lowest/highest possible scores. RESULTS: Average length of stay and number of
      therapy days were 34 (SD = 27.9) and 12 (SD = 13.1), respectively. Box and Block
      Test and Functional Independence Measure-Self-Care showed the highest
      responsiveness with values in the moderate-large range (effect size = 1.09,
      standardized response mean = 1.07 and median-based effect size = 0.76; effect
      size = 0.94, standardized response mean = 1.04 and median-based effect size =
      1.0). Responsiveness of Action Research Arm Test and Upper Limb-Motor Assessment
      Scale were moderate (effect size = 0.58, standardized response mean = 0.69 and
      median-based effect size = 0.59; effect size = 0.62, standardized response mean =
      0.75 and median-based effect size = 0.67). For Manual Muscle Test, responsiveness
      was in the small-moderate range (effect size = 0.42, standardized response mean =
      0.59 and median-based effect size = 0.5). Box and Block Test showed the largest
      floor effect on admission (28%), and Action Research Arm Test and Manual Muscle
      Test showed the largest ceiling effect on discharge (31%). CONCLUSION: These five
      measures varied in their ability to detect change with responsiveness ranging
      from the small to large range. Box and Block Test and Functional Independence
      Measure-Self-Care showed a greater ability to detect change; both demonstrated
      moderate-large responsiveness.

PMID- 29843522
TI  - Culturally responsive approaches to health promotion for Native Hawaiians and
      Pacific Islanders.
AB  - CONTEXT: Obesity, diabetes and cardiovascular disease (CVD) have reached epidemic
      proportions among Native Hawaiians/Pacific Islanders (NHPI). Culturally
      responsive interventions that account for their interpersonal, sociocultural and
      socioeconomic realities are a public health priority. OBJECTIVE: To describe
      cultural adaptation and culturally grounded approaches to developing health
      interventions for NHPI and to review the culturally responsive approaches used
      by, and outcomes from, two long-standing community-based participatory research
      projects (CBPR) in Hawai'i: PILI 'Ohana and KaHOLO Projects. METHODS: A
      literature review of 14 studies from these two projects was done to exemplify the
      methods applied to culturally adapting existing evidence-based interventions and
      to developing novel interventions from the 'ground up' to address health
      disparities in NHPI. Of the 14 studies reviewed, 11 were studies of the clinical
      and behavioural outcomes of both types of interventions. RESULTS: Both culturally
      adapted and culturally grounded approaches using community-based assets and NHPI
      cultural values/practices led to establishing sustainable and scalable
      interventions that significantly improved clinical measures of obesity, diabetes
      and hypertension. CONCLUSION: Several recommendations are provided based on the
      lessons learned from the PILI 'Ohana and KaHOLO Projects. Multidisciplinary and
      transdisciplinary research using CBPR approaches are needed to elucidate how
      human biology is impacted by societal, environmental and psychological factors
      that increase the risk for cardiometabolic diseases among NHPI to develop more
      effective health promotion interventions and public health policies.

PMID- 29843524
TI  - 5th International Workshop on Lung Health-Poster Awards' Winners Abstracts.

PMID- 29843523
TI  - Short- and long-term effects of pulmonary rehabilitation for idiopathic pulmonary
      fibrosis: a systematic review and meta-analysis.
AB  - OBJECTIVE: To investigate the short- and long-term effects of pulmonary
      rehabilitation in patients with idiopathic pulmonary fibrosis (IPF). DATA
      SOURCES: An electronic search of MEDLINE, Embase and Cochrane Central databases
      along with hand search of relevant papers were performed on 15 March 2018. REVIEW
      METHODS: This study was conducted in accordance with the Preferred Reporting
      Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched
      the literature for randomized controlled trials of pulmonary rehabilitation in
      IPF patients. The outcomes were exercise capacity and health-related quality of
      life. Two authors independently extracted data, assessed trial eligibility and
      risk of bias. Meta-analyses were performed using RevMan and STATA software.
      RESULTS: We extracted data from four randomized controlled trials (142
      participants). At short-term follow-up, pulmonary rehabilitation significantly
      enhanced 6-minute walk distance (6-MWD; weighted mean difference (WMD) = 38.38,
      95% confidence interval (CI) = 4.64-72.12, I2 = 60.7%; P < 0.05), reduced St.
      George's Respiratory Questionnaire (SGRQ)/IPF-specific SGRQ (SGRQ-I) total score
      (WMD = -8.40, 95% CI = -11.44 to -5.36, I2 = 0%; P < 0.00001). At long-term
      follow-up, pulmonary rehabilitation could not enhance 6-MWD (WMD = 17.02, 95% CI
      = -26.87 to 60.81, I2 = 36.3%; P = 0.43) or reduce SGRQ/SGRQ-I total score (WMD =
      -3.45, 95% CI = -8.55 to 1.64, I2 = 38.3%; P = 0.088). CONCLUSION: In patients
      with IPF, pulmonary rehabilitation showed short-term effects in enhancing
      exercise capacity and health-related quality of life, while it had no detectable
      effects at long-term follow-up.

PMID- 29843525
TI  - The effects of inspiratory muscle training on exercise capacity, dyspnea and
      respiratory functions in lung transplantation candidates: a randomized controlled
      trial.
AB  - OBJECTIVE: To investigate whether inspiratory muscle training would contribute to
      the improvement of exercise capacity, dyspnea perception and respiratory
      functions in lung transplantation candidates. DESIGN: Prospective randomized
      controlled trial. SETTING: Pulmonary Rehabilitation center. SUBJECTS: A total of
      34 patients with severe lung disease requiring lung transplantation were randomly
      allocated to either pulmonary rehabilitation plus inspiratory muscle training
      group (PR + IMT group, n = 17) or pulmonary rehabilitation group (PR group, n =
      17) before any lung transplantation operation. METHODS: All patients underwent
      supervised pulmonary rehabilitation program on two days per week for three
      months. The PR + IMT group received inspiratory muscle training in addition to
      the standard pulmonary rehabilitation program. The 6-minute walk test, maximal
      inspiratory pressure, modified Medical Research Concile dyspnea scores and
      spirometric parameters were measured for each patient. RESULTS: The PR + IMT
      group had statistically significantly increased in walking distance (100 m, P =
      0.03), maximum inspiratory pressure (26 cmH2O, P = 0.001) and alveolar volume
      ratio of carbonmonoxide diffusion capacity (9%, P = 0.02) than PR group. Although
      both groups demonstrated a statistically significant decrease in the dyspnea
      score, no significant differences were found between the groups ( P = 0.075).
      There was no change in spirometric variables in both groups. CONCLUSION: A
      greater increase in exercise capacity was observed in the PR + IMT group. Our
      study showed that inspiratory muscle training improved exercise capacity even
      further and increased the benefits provided by pulmonary rehabilitation.

PMID- 29843526
TI  - The Role of Palliative Medicine in Assessing Hereditary Cancer Risk.
AB  - BACKGROUND:: Hereditary cancer assessment and communication about family history
      risks can be critical for surviving relatives. Palliative care (PC) is often the
      last set of providers before death. METHODS:: We replicated a prior study of the
      prevalence of hereditary cancer risk among patients with cancer receiving PC
      consultations, assessed the history in the electronic medical record (EMR), and
      explored patients' attitudes toward discussions about family history. This study
      was conducted at an academic urban hospital between June 2016 and March 2017.
      RESULTS:: The average age of the 75 adult patients with cancer was 60 years, 49
      (55%) male and 49 (65%) white. A total of 19 (25%) patients had no clear
      documentation of family history in the EMR, sometimes because no family history
      was included in the admission template or an automatically imported template
      lacked content. In all, 24 (32%) patients had high-risk pedigrees that merited
      referral to genetic services. And, 48 (64%) patients thought that PC was an
      appropriate venue to discuss the implications of family history. The mean comfort
      level in addressing these questions was high. CONCLUSIONS:: At an academic
      center, 25% of patients had no family history documented in the EMR. And, 32% of
      pedigrees warranted referral to genetic services, which was rarely documented.
      There is substantial room for quality improvement for oncologists and PC
      specialists-often the last set of providers-to address family cancer risk before
      death and to increase use and ease of documenting family history in the EMR.
      Addressing cancer family history could enhance prevention, especially among high
      risk families.

PMID- 29843527
TI  - Small GTPase RIT1 in Mouse Retina; Cellular and Functional Analysis.
AB  - PURPOSE: Ras-like without CAAX 1 (RIT1/Rit) is a member of the Ras subfamily of
      small GTP-binding proteins with documented roles in regulating neuronal function,
      including contributions to neurotrophin signaling, neuronal survival, and
      neurogenesis. The aim of the study was to (1) examine the expression of RIT1
      protein in mouse retina and retinal cell types and (2) determine whether RIT1
      contributes to retinal ganglion cell (RGC) survival and synaptic stability
      following excitotoxic stress. MATERIALS AND METHODS: Gene expression and
      immunohistochemical analysis were used to examine RIT1 expression in the mouse
      retina. Primary RGC and Muller glia cultures were used to validate novel RIT1
      lentiviral RNAi silencing reagents, and to demonstrate that RIT1 loss does not
      alter RGC morphology. Finally, in vitro glutamate exposure identified a role for
      RIT1 in the adaptation of RGCs to excitotoxic stress. RESULTS: Gene expression
      analysis and immunohistochemical studies in whole eyes and primary cell culture
      demonstrate RIT1 expression throughout the retina, including Muller glia and
      RGCs. While genetic RIT1 knockout (RIT1-KO) does not affect gross retinal
      anatomy, including the thickness of constituent retinal layers or RGC cell
      numbers, RNAi-mediated RIT1 silencing results in increased RGC death and synaptic
      loss following exposure to excitotoxic stress. CONCLUSIONS: RIT1 is widely
      expressed in the murine retina, including both Muller glia and RGCs. While
      genetic deletion of RIT1 does not result in gross retinal abnormalities, these
      studies identify a novel role for RIT1 in the adaptation of RGC to excitotoxic
      stress, with RIT1 promoting both neuronal survival and the retention of PSD-95+
      synapses.

PMID- 29843528
TI  - A pilot randomised controlled trial of a home-based writing intervention for
      individuals with seizures.
AB  - OBJECTIVE: We investigated the feasibility, acceptability and preliminary
      effectiveness of a writing intervention for individuals with epilepsy or
      psychogenic nonepileptic seizures. METHODS: Individuals were randomised to write
      about potentially 'therapeutic' topics (n = 43) or about their daily events (n =
      25). Participants were asked to write on four separate occasions for at least 20
      min. Repeated-measures analysis of variance was used to investigate change in
      measures of health-related quality of life (NEWQoL-6D), depression (NDDI-E),
      anxiety (GAD-7) and illness perception (B-IPQ) from baseline to one and three
      month follow-ups. Qualitative and quantitative data taken from a Writing Task
      Questionnaire was analysed between the two conditions. RESULTS: Recruitment was
      acceptable with 52% of those randomised completing the full writing intervention.
      In both conditions, participants wrote for longer than 20 min suggesting those
      who completed the study engaged well with the procedure. Greater benefits were
      observed in the 'therapeutic' condition (p < 0.05), which was associated with an
      improvement in health-related quality of life at one-month follow-up (p = 0.02).
      No differences were found in the other measures. CONCLUSIONS: A writing
      intervention is acceptable in this population. Self-reported benefits were
      modest, suggesting therapeutic writing may be more suitable as a supplement to
      other therapies rather than a stand-alone therapeutic intervention.

PMID- 29843529
TI  - Investigating the combined effect of pelvic floor muscle exercise and mindfulness
      on sexual function in women with multiple sclerosis: a randomized controlled
      trial.
AB  - OBJECTIVE: To evaluate the combined effect of pelvic floor muscle exercise and
      mindfulness on sexual function in women with multiple sclerosis. DESIGN: It was a
      three-arm parallel randomized clinical trial study. SETTING: Outpatient clinic.
      SUBJECTS: Patients with multiple sclerosis. INTERVENTIONS: Participants in the
      intervention groups completed an eight-week program consisting of pelvic floor
      muscle exercise, mindfulness, and pelvic floor muscle exercise along with
      mindfulness. MAIN MEASURES: The main measure was the Female Sexual Function
      Index. RESULTS: In total, 70 patients completed the study. The results showed
      that the total mean scores of the participants' sexual function in pelvic floor
      muscle exercise group before interventions (i.e. baseline), 8 weeks after the
      baseline, and 12 weeks after the baseline were 18.8 +/- 6.3, 23.7 +/- 5.1, and
      22.3 +/- 4.7, respectively, while total mean scores obtained for the sexual
      function of mindfulness group were 19.5 +/- 6.4, 26.9 +/- 4.8, and 25.6 +/- 4.5,
      respectively. Moreover, mean scores obtained for pelvic floor muscle exercise
      along with mindfulness were 19.6 +/- 5.9, 25.3 +/- 5.4, and 25 +/- 4.8,
      respectively. There was no significant difference in their effects on sexual
      function ( P > 0.05). CONCLUSION: Mindfulness and pelvic floor muscle exercise do
      not have any significant impact upon sexual dysfunction of people with multiple
      sclerosis.

PMID- 29843530
TI  - Repeated phytoextraction of metal contaminated calcareous soil by
      hyperaccumulator Sedum plumbizincicola.
AB  - Most studies on the phytoextraction of cadmium (Cd) and zinc (Zn) by the
      hyperaccumulator Sedum plumbizincicola (S. plumbizincicola) have been conducted
      in metal contaminated acid and neutral soils. However, little information is
      available on phytoremediation of calcareous soils. Two experiments were conducted
      to investigate the phytoextraction efficiency of S. plumbizincicola in a
      contaminated calcareous soil in He'nan province, north China. In a field
      experiment there was no significant decrease in shoot biomass production or metal
      (Cd and Zn) concentration in the shoots after three successive repeated
      phytoextractions. Repeated phytoextraction had no significant effect on the
      percentage distribution of Cd or Zn fractions in the soil even though the soil
      total Cd and Zn concentrations decreased by 32.8 and 19.7%, respectively. In a
      pot experiment the shoot biomass production and Zn and Cd uptake by S.
      plumbizincicola increased significantly with growth in metal contaminated
      calcareous soil amended with organic fertilizer, perlite and vermiculite. The
      results indicate that S. plumbizincicola can maintain sustainable uptake of Cd
      and Zn from the calcareous soil and enhancement of soil fertility and structure
      will significantly increase the phytoextraction efficiency.

PMID- 29843531
TI  - A New Model for Acquiescence at the Interface of Psychometrics and Cognitive
      Psychology.
AB  - When measuring psychological traits, one has to consider that respondents often
      show content-unrelated response behavior in answering questionnaires. To
      disentangle the target trait and two such response styles, extreme responding and
      midpoint responding, Bockenholt ( 2012a ) developed an item response model based
      on a latent processing tree structure. We propose a theoretically motivated
      extension of this model to also measure acquiescence, the tendency to agree with
      both regular and reversed items. Substantively, our approach builds on
      multinomial processing tree (MPT) models that are used in cognitive psychology to
      disentangle qualitatively distinct processes. Accordingly, the new model for
      response styles assumes a mixture distribution of affirmative responses, which
      are either determined by the underlying target trait or by acquiescence. In order
      to estimate the model parameters, we rely on Bayesian hierarchical estimation of
      MPT models. In simulations, we show that the model provides unbiased estimates of
      response styles and the target trait, and we compare the new model and
      Bockenholt's model in a recovery study. An empirical example from personality
      psychology is used for illustrative purposes.

PMID- 29843533
TI  - Erratum.

PMID- 29843532
TI  - Increased GOLM1 Expression Independently Predicts Unfavorable Overall Survival
      and Recurrence-Free Survival in Lung Adenocarcinoma.
AB  - Golgi membrane protein 1 (GOLM1) is a transmembrane glycoprotein of the Golgi
      cisternae, which is implicated in carcinogenesis of multiple types of cancer. In
      this study, using data from the Gene Expression Omnibus and The Cancer Genome
      Atlas, we compared the expression of GOLM1 in lung adenocarcinoma (LUAD) and lung
      squamous cell carcinoma (LUSC) and studied its prognostic value in terms of
      overall survival (OS) and recurrence-free survival (RFS) in these 2 subtypes of
      non-small cell lung cancer (NSCLC). Results showed that GOLM1 was significantly
      upregulated in both LUAD and LUSC tissues compared to the normal controls.
      However, GOLM1 expression was higher in LUAD tissues than in LUSC tissues. More
      importantly, using over 10 years' survival data from 502 patients with LUAD and
      494 patients with LUSC, we found that high GOLM1 expression was associated with
      unfavorable OS and RFS in patients with LUAD, but not in patients with LUSC. The
      following univariate and multivariate analyses confirmed that increased GOLM1
      expression was an independent prognostic indicator of poor OS (hazard ratio [HR]:
      1.30, 95% confidence interval [CI]: 1.11-1.54, P = .002) and RFS (HR: 1.37, 95%
      CI: 1.14-1.64, P = .001) in patients with LUAD. Of 511 cases with LUAD, 248
      (48.5%) had heterozygous loss (-1), while 28 (5.5%) of 511 cases with LUAD had
      low-level copy gain (+1). In addition, we also found that the methylation status
      of 1 CpG site (chr9: 88,694,942-88,694,944) showed a weak negative correlation
      with GOLM1 expression (Pearson r = -0.25). Based on these findings, we infer that
      GOLM1 might serve as a valuable prognostic biomarker in LUAD, but not in LUSC. In
      addition, DNA copy number alterations and methylation might be 2 important
      mechanisms of dysregulated GOLM1 in LUAD.

PMID- 29843534
TI  - Racial/ethnic differences in correlates of psychological distress among five
      Asian-American subgroups and non-Hispanic Whites.
AB  - OBJECTIVE: Despite their vastly different historical backgrounds, unique
      languages and variable pre- and post-immigration experiences, Asian-Americans are
      considered to share stressors surrounding immigration, but there is a gap in
      describing manifestations of possible mental distress. Thus, the purpose of this
      study was to explore and compare differences in factors associated with
      psychological distress among Asian subgroups including Chinese, Filipino,
      Vietnamese, Korean, Japanese, and non-Hispanic Whites. DESIGN: Using a cross
      sectional study design, California Health Interview Survey (CHIS) 2011/2012 data
      were analyzed. The sample consisted of 29,142 participants: 25,645 non-Hispanic
      Whites, 3497 non-Hispanic Asian-Americans, 1156 Chinese, 471 Filipinos, 864
      Vietnamese, 704 Koreans, and 302 Japanese. Sociodemographic characteristics
      included gender, age group, marital status, education, poverty level, working
      status, health insurance, level of acculturation, social cohesion, neighborhood
      safety, and civic engagement. Physical health status included disability and
      chronic illness. Psychological distress was evaluated using the Kessler 6 (K6)
      scale. RESULTS: Results showed that psychological distress levels ranged between
      1.96 and 4.52 (p < .05) out of 24 and associated factors were significantly
      different among the five Asian subgroups and non-Hispanic Whites. CONCLUSIONS:
      The current study highlights the differences in characteristics of psychological
      distress among Asian subgroups. It underscores the significance of understanding
      individualized cultural and historical background in each Asian subgroup and
      subsequently developing and applying appropriate interventions for those groups.
      In addition, different influencing factors should be applied to assess and
      prioritize the needs of Asian subgroups to improve psychological distress. The
      study also warrants further investigation and careful description of each Asian
      subgroups.

PMID- 29843535
TI  - Ability of the Public to Recognize Dogs Considered to Be Dangerous under the
      Dangerous Dogs Act in the United Kingdom.
AB  - Canine aggression came into the public eye in the United Kingdom in the late
      1980s prompting enactment of the UK Dangerous Dogs Act , which prohibits four
      breeds or "types" of dogs. The act faced strong opposition surrounding correct
      identification of prohibited dogs. A questionnaire was distributed  to the public
      via an online platform, especially  targetting those who have worked with dogs.
      The questionnaire assessed respondents' abilities to identify the four banned
      types of dogs from other breeds and their capability to identify Pit Bull Terrier
      types from other similar dog types. Identification of both banned breeds, F(1,
      20) = 57.746, p < .001, and bull breeds, F(1, 20) = 9.293, p = .006, was
      significantly lower than identification of other breeds. Recognition of Pit Bull
      Terrier types from similar types of dogs was generally poor, although people in a
      dog-related profession, as opposed to those in other professions, could correctly
      distinguish more pit bull-type dogs (U = 46,164.0, n1 = 187, n2 = 575, p = .003).
      Findings suggest public understanding of dangerous dogs is poor, and it may
      impact societal perceptions of dogs more widely.

PMID- 29843536
TI  - Identification and treatment of residual and relapsed idiopathic clubfoot in 88
      children.
AB  - Background and purpose - The Ponseti treatment is successful in idiopathic
      clubfoot. However, approximately 11-48% of all clubfeet maintain residual
      deformities or relapse. Early treatment, which possibly reduces the necessity for
      additional surgery, requires early identification of these problematic clubfeet.
      We identify deformities of residual/relapsed clubfeet and the treatments applied
      to tackle these deformities in a large tertiary clubfoot treatment center.
      Patients and methods - Retrospective chart review of patients who visited our
      clinic between 2012 and 2015 focused on demographics, deformities of the
      residual/relapsed clubfoot, and applied treatment. Residual deformities were
      defined as deformities that were never fully corrected and needed additional
      treatment. We defined relapse as any deformity of the clubfoot reoccurring, after
      initial successful treatment, with necessity for additional treatment. Results -
      We identified 33 patients with residual and 55 patients with relapsed clubfeet.
      In both groups decreased dorsal flexion and adduction were the most often
      registered deformities. Furthermore, often equinus/decreased dorsiflexion, active
      supination, and varus occurred. In more than half, typical profiles of combined
      deformities were found. Relapses occurred at all stages of treatment and follow
      up; half of the residual or relapsed clubfeet were identified before the end of
      the bracing period. In half of the patients, additional treatment consisted of
      the Ponseti treatment, one-quarter also required adaptation of the brace
      protocol, and one-quarter needed additional surgery. The Ponseti treatment was
      mainly reapplied if feet presented with relapses or residues until the age of 5.
      Interpretation - Practitioners should especially be aware of equinus/decreased
      dorsiflexion, adduction, and active supination as a sign of a residual or
      relapsed clubfoot. Due to the heterogeneous profiles of these clubfeet, treatment
      strategy should be based on a step-by step approach including recasting, bracing,
      and if necessary surgical intervention.

PMID- 29843537
TI  - Antenatal Diagnosis of Fetal Retinoid Syndrome at 20 Weeks of Gestation: A Case
      Report.
AB  - INTRODUCTION: Isotretinoin, a synthetic derivative of vitamin A, is one of the
      most potent human teratogens, and is mainly utilized for the treatment of severe
      recalcitrant nodular acne. Retinoic acid embryopathy is well defined in the
      literature. CASE REPORT: The mother was referred for a fetal posterior fossa
      abnormality, first detected at 20 weeks of gestation. The mother used
      isotretinoin until 18 weeks gestation. Ultrasound examination revealed
      hypertelorism, cerebellar hypoplasia, vermian agenesis, truncus arteriosus,
      anotia, thymic aplasia, corpus callosum hypoplasia. An intrauterine diagnosis of
      fetal retinoid syndrome was confirmed by fetopsy after termination of pregnancy.
      CONCLUSION: The typical findings of fetal retinoid syndrome can be visualized
      with ultrasound in early second trimester.

PMID- 29843538
TI  - Social support and clinical and functional outcome in people with schizophrenia.
AB  - PURPOSE: The impact of Social Support (SS) on the clinical and functional
      evolution of patients diagnosed with schizophrenia was studied from a
      multidimensional concept of SS in the framework of the vulnerability-stress
      model. METHODS: In total, 152 patients diagnosed with schizophrenia according to
      the International Classification of Diseases, Tenth Edition (ICD-10) treated in a
      Community Mental Health Unit were assessed using the Mannheim Interview on Social
      Support (MISS) and the Brief Psychiatric Rating Scale (BPRS). Then they were
      followed up for 3 years with a final assessment for the period using the Social
      Functioning Scale. The impact of SS was explored in clinical and functional
      measurements with a multiple regression analysis in a 3-year longitudinal
      prospective design. RESULTS: The quality of Global Social Support (GSS) and
      satisfaction with GSS appeared to be protective factors from frequency and
      duration of hospital admissions, with explanatory intensity varying from 9% in
      survival time to relapse to 13% in number of relapses. Concerning functional
      measurements, GSS quantity, quality and satisfaction showed an explanatory power
      for several different dimensions of social functioning, varying from 12% in
      isolation to 20% in communication. CONCLUSION: The results confirm SS as a
      protective factor in the evolution of schizophrenia patients and enable the SS
      variables with the most explanatory power in their clinical and functional
      evolution to be identified.

PMID- 29843539
TI  - Pharmacophore modeling, molecular docking and molecular dynamics studies on
      natural products database to discover novel skeleton as non-purine xanthine
      oxidase inhibitors.
AB  - Gout is a common inflammatory arthritis caused by the deposition of urate
      crystals within joints. It is increasingly in prevalence during the past few
      decades as shown by the epidemiological survey results. Xanthine oxidase (XO) is
      a key enzyme to transfer hypoxanthine and xanthine to uric acid, whose
      overproduction leads to gout. Therefore, inhibiting the activity of xanthine
      oxidase is an important way to reduce the production of urate. In the study, in
      order to identify the potential natural products targeting XO, pharmacophore
      modeling was employed to filter databases. Here, two methods, pharmacophore based
      on ligand and pharmacophore based on receptor-ligand, were constructed by
      Discovery Studio. Then GOLD was used to refine the potential compounds with
      higher fitness scores. Finally, molecular docking and dynamics simulations were
      employed to analyze the interactions between compounds and protein. The best
      hypothesis was set as a 3D query to screen database, returning 785 and 297
      compounds respectively. A merged set of the above 1082 molecules was subjected to
      molecular docking, which returned 144 hits with high-fitness scores. These
      molecules were clustered in four main kinds depending on different backbones.
      What is more, molecular docking showed that the representative compounds
      established key interactions with the amino acid residues in the protein, and the
      RMSD and RMSF of molecular dynamics results showed that these compounds can
      stabilize the protein. The information represented in the study confirmed
      previous reports. And it may assist to discover and design new backbones as
      potential XO inhibitors based on natural products.

PMID- 29843540
TI  - The Impact of Micropapillary Component Ratio on the Prognosis of Patients With
      Invasive Micropapillary Breast Carcinoma.
AB  - BACKGROUND AND OBJECTIVES: Invasive micropapillary carcinoma (IMPC) of the breast
      is a rare and aggressive variant of invasive ductal carcinoma characterized by
      high-grade lymphovascular invasion and high rates of nodal metastasis. The
      prognostic significance of the micropapillary component (MC) ratio that
      constitutes this aggressive variation is controversial. In this study, we aimed
      to investigate the effect of the MC ratio on the prognosis of these patients.
      METHODS: The data of 47 patients with IMPC were retrospectively reviewed.
      Patients were divided into two groups: MC ratio of 10-75% (Group 1) and greater
      than 75% (Group 2). The demographic characteristics of the patients,
      histopathologic features of the tumors, and survival rates were compared.
      RESULTS: We detected no significant difference in demographic characteristics
      between groups 1 and 2 (p = 0.21). No significant difference was detected in
      terms of tumor diameter, lymph node metastasis, lymphovascular invasion,
      histologic grade, multicentricity, local recurrence, distant metastasis, and
      overall survival. CONCLUSION: In the micropapillary subgroup of invasive ductal
      carcinoma, although positive receptor characteristics are directly proportional
      to the increase in MC ratio, recurrence and survival rates are not affected by
      micropapillary component level.

PMID- 29843541
TI  - Hemoadsorption in cardiac shock with bi ventricular failure and giant-cell
      myocarditis: A case report.
AB  - PURPOSE: Giant-cell myocarditis represents a rare and often fatal autoimmune
      disorder. Despite extracorporeal life support being a valid treatment option,
      alternatives to control the underlying inflammatory response remain sparse. A new
      hemoadsorption device (CytoSorb) has recently been introduced to treat patients
      with an excessive inflammatory response. METHODS: A 57-year-old patient developed
      fulminant right heart failure, respiratory insufficiency, hemodynamic
      instability, and oliguric-anuric renal failure. An extracorporeal life support
      together with an Impella was implanted for circulatory support. Due to non
      pulsatility, acontractility of the left ventricle and a heavily reduced right
      ventricular function, a left ventricular assist device implantation and change
      from extracorporeal life support to veno-pulmonary arterial extracorporeal
      membrane oxygenation was performed. Since adequate hemodynamic stabilization
      could not be achieved and due to increasing inflammatory mediators and bilirubin
      levels, the decision was made to additionally integrate a CytoSorb hemoadsorber
      into the system. RESULTS: The combined treatment resulted in a clear and steady
      improvement in hemodynamics and the inflammatory condition with marked reductions
      in all measured parameters throughout the treatment period. Metabolic acidosis
      resolved and liver function improved. CONCLUSION: Extracorporeal life support
      therapy represents a bridging approach to heart transplantation or to cardiac
      recovery and can be complemented by CytoSorb as an independent therapeutic
      option. The patient described herein with giant-cell myocarditis and fulminant
      cardiac failure who received substantial extracorporeal support in combination
      with CytoSorb hemoadsorption therapy benefited in terms of an improvement of
      organ function and his inflammatory situation.

PMID- 29843542
TI  - A Fully Automated High-Throughput Flow Cytometry Screening System Enabling
      Phenotypic Drug Discovery.
AB  - The goal of high-throughput screening is to enable screening of compound
      libraries in an automated manner to identify quality starting points for
      optimization. This often involves screening a large diversity of compounds in an
      assay that preserves a connection to the disease pathology. Phenotypic screening
      is a powerful tool for drug identification, in that assays can be run without
      prior understanding of the target and with primary cells that closely mimic the
      therapeutic setting. Advanced automation and high-content imaging have enabled
      many complex assays, but these are still relatively slow and low throughput. To
      address this limitation, we have developed an automated workflow that is
      dedicated to processing complex phenotypic assays for flow cytometry. The system
      can achieve a throughput of 50,000 wells per day, resulting in a fully automated
      platform that enables robust phenotypic drug discovery. Over the past 5 years,
      this screening system has been used for a variety of drug discovery programs,
      across many disease areas, with many molecules advancing quickly into preclinical
      development and into the clinic. This report will highlight a diversity of
      approaches that automated flow cytometry has enabled for phenotypic drug
      discovery.

PMID- 29843543
TI  - Use of a fracture prevention screening algorithm predicts self-reported falls in
      postmenopausal women.
AB  - BACKGROUND AND PURPOSE: The prevention of falls and fall-related fractures
      following menopause is an important health initiative. The Fracture Prevention
      Screening Algorithm (FPSA) uniquely uses fracture risk to prompt fall risk
      assessment to classify both fall and fracture risk in individuals. The purpose of
      this study was to determine whether use of the FPSA accurately predicted self
      reported falls in post-menopausal women over one year. METHODS: 142
      postmenopausal women were recruited. Based on Fracture Risk Assessment Tool
      (FRAX(r)) scores, women with a >=3% 10-year probability of hip fracture (high
      risk), or who self-identified as having balance problems or a fall history,
      underwent the Functional Gait Assessment (FGA) to estimate fall risk (high risk =
      <=22/30). This allowed classification on the FPSA into one of four risk
      categories: low fall/low fracture risk; low fall/high fracture risk; high
      fall/low fracture risk; high fall/high fracture risk. Participants were contacted
      monthly for one year to determine fall and injury occurrence. RESULTS:
      Fall/injury surveillance was conducted with 136 subjects over one year. Compared
      to women in the low fall/low fracture risk group, both high fall risk groups
      demonstrated significantly greater fall rates. Falls were 81-89% more likely in
      women with FGA scores of 22/30 or less. All injuries were rare events across all
      risk strata and did not differ between risk groups. CONCLUSION: These findings
      support the use of fracture risk as a trigger for fall screening to
      comprehensively classify risk in post-menopausal women as proposed by the FPSA.

PMID- 29843545
TI  - Using Twitter to recruit participants for health research: An example from a
      caregiving study.
AB  - Twitter has the potential to optimize research conduct, but more research is
      needed around the nature of study-related tweets and strategies for optimizing
      reach. In the context of our caregiving study, we aimed to describe the nature
      and extent of study-related tweets, the extent to which they were shared by
      others, and their potential reach. To do so, we conducted a secondary analysis of
      our Twitter recruitment. We aggregated and categorized study-related tweets and
      analyzed the reach of the 10 most retweeted tweets. Results indicated that of 71
      caregivers, 27 were recruited via Twitter. General recruitment tweets were most
      shared by users. Tweet reach ranged from 5273 to 62,144 users. Twitter caregivers
      were demographically comparable to non-Twitter caregivers but had higher Internet
      proficiency and fewer children. Overall, using a personal Twitter account can
      expand the reach of study recruitment. Future research should compare different
      recruitment strategies and explore characteristics that may challenge the
      heterogeneity of Twitter samples.

PMID- 29843544
TI  - Validation of in vitro assays in three-dimensional human dermal constructs.
AB  - Three-dimensional cell culture systems are urgently needed for cytocompatibility
      testing of biomaterials. This work aimed at the development of three-dimensional
      in vitro dermal skin models and their optimization for cytocompatibility
      evaluation. Initially "murine in vitro dermal construct" based on L929 cells was
      generated, leading to the development of "human in vitro dermal construct"
      consisting of normal human dermal fibroblasts in rat tail tendon collagen type I.
      To assess the viability of the cells, different assays CellTiter-Blue(r),
      RealTime-GloTM MT, and CellTiter-Glo(r) (Promega) were evaluated to optimize the
      best-suited assay to the respective cell type and three-dimensional system. Z
      stack imaging (Live/Dead and Phalloidin/DAPI-Promokine) was performed to
      visualize normal human dermal fibroblasts inside matrix revealing filopodia-like
      morphology and a uniform distribution of normal human dermal fibroblasts in
      matrix. CellTiter-Glo was found to be the optimal cell viability assay among
      those analyzed. CellTiter-Blue reagent affected the cell morphology of normal
      human dermal fibroblasts (unlike L929), suggesting an interference with cell
      biological activity, resulting in less reliable viability data. On the other
      hand, RealTime-Glo provided a linear signal only with a very low cell density,
      which made this assay unsuitable for this system. CellTiter-Glo adapted to three
      dimensional dermal construct by optimizing the "shaking time" to enhance the
      reagent penetration and maximum adenosine triphosphate release, indicating 2.4
      times higher viability value by shaking for 60 min than for 5 min. In addition,
      viability results showed that cells were viable inside the matrix. This model
      would be further advanced with more layers of skin to make a full thickness
      model.

PMID- 29843546
TI  - Collaboration is key to accelerating diagnostics access to optimize benefits of
      precision medicines.

PMID- 29843547
TI  - Prediction of spontaneous preterm birth: salivary progesterone assay and
      transvaginal cervical length assessment after 24 weeks of gestation, another
      critical window of opportunity.
AB  - OBJECTIVES: Measurement of salivary progesterone (SP4) levels and cervical length
      (CL) after 24 weeks to assess their potential predictive value among asymptomatic
      women at high risk of spontaneous preterm birth (PTB). METHODS: This prospective
      observational (noninterventional) study consecutively recruited asymptomatic
      women at high risk of spontaneous PTB. SP4 and CL were measured at recruitment
      (24-28 weeks of gestation) then repeated after 3-4 weeks. All recruited women
      were followed up regularly till delivery. The primary outcome measure was the
      occurrence of spontaneous PTB. RESULTS: One hundred and thirty four women
      completed the study, 22 (16.4%) and 32 (23.9%) women had early (<34 weeks) and
      late (>=34 weeks) PTB, respectively. Initially, the mean CL was 3.2 +/- 0.6 cm
      and the mean SP4 was 4062.8 +/- 814.6 pg/ml; with follow up, the mean CL became
      3.0 +/- 0.6 cm and the mean SP4 became 3871.6 +/- 1136.9. Women with early PTB
      had significantly lower initial and follow up CL and SP4 measures when compared
      to women with late PTB and those who had birth at term. The rate of drop in SP4
      and CL measurements between the two visits was also significantly higher among
      women with early PTB than those with late PTB and term birth. Receiver-operating
      characteristic (ROC) curves showed that, CL was a good predictor but SP4 was a
      better predictor of PTB as the area under the curve (AUC) for CL was less than
      that for SP4 at both visits (i.e. 0.858 and 0.868 versus 0.986 and 0.990 at the
      initial and follow up visits, respectively). There was a statistically
      significant correlation between CL and SP4 measurements. Multivariable binary
      logistic regression analysis revealed that follow up SP4 measurement was the only
      independent predictor of spontaneous PTB, and neither BMI, maternal age, SP4 nor
      CL were independent predictors of early spontaneous PTB. CONCLUSIONS: After 24
      gestational weeks, SP4 assessment is a simple and reliable promising tool to
      predict spontaneous PTB among asymptomatic high-risk women, with a little
      superior performance than CL measurement.

PMID- 29843549
TI  - Associations Between Initial Subjective Experiences with Tobacco and Self
      Reported Recent Use in Young Adulthood.
AB  - BACKGROUND: Youth tobacco use behaviors are predictive of patterns in adulthood
      and effect long-term health outcomes. Yet, few studies have examined the effect
      of initial subjective experiences (ISEs) during first tobacco use, which has been
      found to be an indicator of individuals. sensitivity to nicotine and
      vulnerability to dependence. OBJECTIVE: The present study aimed to determine the
      prevalence of ISEs across a variety of tobacco products, evaluate the factor
      structure of ISEs by first tobacco product used, and examine the relationship
      between ISEs and recent (30-day) use of tobacco products across time, using a
      university sample. METHODS: Exploratory factor analyses were conducted to
      identify latent factors present with respect to items measuring ISEs with
      tobacco, separately by tobacco product (e.g. cigarettes, cigars, hookah, e
      cigarettes). Factor scores for positive and negative ISEs were calculated.
      Multiple logistic regression analyses were conducted to examine associations
      between ISEs and recent use of each tobacco product, adjusted for age at first
      use, sex, race/ethnicity, and cohort. RESULTS: ISEs differ by the first tobacco
      product used. Associations between factor scores for positive and negative ISEs
      and recent use were found across a variety of tobacco products. Overall, positive
      ISEs were more strongly associated with recent use, relative to negative ISEs.
      CONCLUSIONS: Further research is needed to identify genetic and biological
      pathways and social contexts influencing initial subjective experiences with
      tobacco use, in efforts to delay the initiation for tobacco use and reduce risk
      for continued use among young adults.

PMID- 29843550
TI  - The polymorphisms of growth factor genes (VEGFA & EGF) were associated with
      response to acitretin in psoriasis.
AB  - AIM: VEGF and EGF are assumed to be involved in the pathogenesis of psoriasis,
      while the impacts of their polymorphisms on psoriasis are inconsistent.
      Therefore, we hope to clarify these relationships in the Chinese Han population.
      METHODS: A total of 131 patients with psoriasis vulgaris and 176 controls were
      enrolled. The polymorphisms rs833061 (T > C), rs10434 (G > A) in VEGFA, and
      rs4444903 (G > A), rs2237051 (A > G) in EGF of each participant were detected.
      The patients were treated with calcipotriol plus acitretin 30 mg/day for 8 weeks.
      RESULTS: No SNPs of rs833061, rs10434, rs4444903 and rs2237051 were found to be
      associated with psoriasis susceptibility and efficacy. Although the mutation of
      rs10434A was associated with baseline disease severity (p = 0.026), and
      rs2237051G allele was associated with increased erythema during treatment (p =
      0.015). CONCLUSION: The allele of rs2237051 G increased the erythema during the
      treatment, and no polymorphism of VEGF and EGF gene was found to be associated
      with the susceptibility and efficacy in psoriasis.

PMID- 29843548
TI  - Cannabis regulatory science: risk-benefit considerations for mental disorders.
AB  - The evolving legal cannabis landscape in the US continues to present novel
      regulatory challenges that necessitate the development of a Cannabis Regulatory
      Science. Two specific issues of concern within Cannabis Regulatory Science are
      (1) the impact that cannabis use has on the incidence, prevalence, and severity
      of mental disorders, and (2) how cannabis laws and regulations modify this
      impact. This paper first provides several conceptual points that are useful for
      evaluating the relationship between cannabis use and mental disorders. Second, it
      selectively reviews and comments on data relevant to the relationship between
      cannabis use and depression, several forms of anxiety, post-traumatic stress
      disorder, schizophrenia, and bipolar disorder. Next, regulatory and public health
      parallels between the nascent cannabis industry and the pharmaceutical, tobacco,
      and alcohol industries are discussed. The focus is on specific types of industry
      practices that may harm those with or at risk for mental disorders.
      Recommendations are then offered for legal cannabis regulations that could
      mitigate this harm. Last, future research goals are discussed for building the
      field of Cannabis Regulatory Science and addressing the potential negative impact
      of cannabis on those with mental disorders.

PMID- 29843551
TI  - Rupture of a true brachial artery aneurysm in a kidney transplant patient after
      arteriovenous fistula ligation: A rare presentation of an unusual disease.

PMID- 29843552
TI  - Electrospun poly(vinyl) alcohol/collagen nanofibrous scaffold hybridized by
      graphene oxide for accelerated wound healing.
AB  - PURPOSE: In this study, a blend of synthetic polymer (poly(vinyl) alcohol),
      natural polymer (collagen type I from fish bone), and graphene oxide
      nanoparticles is used to fabricate a composite nanofibrous scaffold, by
      electrospinning, for their potential application in accelerated wound healing.
      METHODS: The scaffold was characterized for its physicochemical and mechanical
      properties. In vitro studies were carried out using human keratinocyte cell line
      (HaCaT) which proved the biocompatibility of the scaffold. In vivo study using
      mice model was carried out and the healing pattern was evaluated using
      histopathological studies. RESULTS: Scaffold prepared from poly(vinyl) alcohol,
      collagen type I from fish bone, and graphene oxide possessed better
      physicochemical and mechanical properties. In addition, in vivo and in vitro
      studies showed its accelerated wound healing properties. CONCLUSION: The scaffold
      with required strength and biocompatibility may be tried as a wound dressing
      material in large animals after getting necessary approval.

PMID- 29843553
TI  - Efficacy of ferrous bis-glycinate versus ferrous glycine sulfate in the treatment
      of iron deficiency anemia with pregnancy: a randomized double-blind clinical
      trial.
AB  - OBJECTIVE: The aim of this study is to compare the efficacy and tolerability of
      oral ferrous bis-glycinate versus ferrous glycine sulfate in the treatment of
      iron deficiency anemia (IDA) with pregnancy. METHODS: A randomized double-blind
      clinical trial (NCT02590224) conducted at a tertiary University Hospital in the
      period between 1 January 2016 and 31 July 2017 included pregnant women at 14-18
      weeks of gestation with mild to moderate IDA. Patients were randomized into two
      groups: (Group I) received oral ferrous bis-glycinate tablets once daily for
      eight consecutive weeks and (Group II) received oral ferrous glycine sulfate
      capsules in the same dose and duration. The primary outcome of the study was the
      rate of increase of hemoglobin (HB) level after 8 weeks of iron treatment.
      RESULTS: The study included 187 women in the final analysis. The mean increase in
      HB level after 8 weeks of treatment in ferrous bis-glycinate group was 2.48 +/-
      0.12 g/dL versus 1.32 +/- 0.18 g/dL in ferrous glycine sulfate group (p <=
      .0001). The percentage of women with HB level more than 11 g/dL after 8 weeks of
      treatment was 89.2% in ferrous bis-glycinate group versus 71.3% in ferrous
      glycine sulfate group (p < .0001). The rate of adverse effects was significantly
      higher in ferrous glycine sulfate group (p = .001). CONCLUSIONS: Pregnant women
      with second trimester IDA could be supplied with ferrous bis-glycinate which is
      more efficient in increasing HB level. Moreover, it has tolerable adverse effects
      and high compliance than ferrous glycine sulfate.

PMID- 29843554
TI  - Early cannulation grafts for haemodialysis: An updated systematic review.
AB  - PURPOSE: Early cannulation grafts are specifically designed for dialysis, whereas
      standard expanded polytetrafluoroethylene grafts were not. There is developing
      collective experience and literature available to allow the assessment of
      outcomes of these early cannulation grafts. The aim of this review was to review
      the evidence for both short- and long-term outcomes of early cannulation grafts.
      METHODS: Using standardized searches of electronic databases in accordance with
      Preferred Reporting Items for Systematic Reviews and Meta-Analyses, the primary
      outcomes for this study were primary and secondary patency rates for early
      cannulation grafts for dialysis at 12 months and beyond. Secondary outcomes were
      timing of first cannulation, rates of access thrombosis, steal syndrome, pseudo
      aneurysm and infection. RESULTS: A total of 19 studies were identified and
      included. These were divided into different graft types. FlixeneTM, AvfloTM,
      AcusealTM and VectraTM grafts all showed that early cannulation within 72 h is
      possible. Twelve-month pooled primary and secondary patency rates were 43.3% (95%
      confidence interval: 31.6-55.4) and 73.4% (95% confidence interval: 63-82.7) for
      the Flixene graft, 58.2% (95% confidence interval: 48-68.1) and 79.2% (95%
      confidence interval: 68-88.7) for the Avflo graft, 43.6% (95% confidence
      interval: 30.7-56.9) and 70.5% (95% confidence interval: 49.7-87.8) for the
      Acuseal graft and 63.7% (95% confidence interval: 53.4-73.4) and 85.8% (95%
      confidence interval: 82.9-88.4) for the Vectra graft. Data for outcome beyond 12
      months were limited to the more recent studies. CONCLUSION: This review confirms
      that early cannulation is not detrimental on the early outcome of early
      cannulation graft patencies. It has also shown that both Vectra and Avflo grafts
      have adequate long-term patencies. The data do not allow specific graft
      recommendations, as comparative trials would be required.

PMID- 29843555
TI  - Prevalence and correlates of major depression in Granada, Spain: Results from the
      GranadSigmap study.
AB  - BACKGROUND: Major depression is one of the world's leading causes of disability.
      Up-to-date information about the epidemiology of this disorder is key to health
      care planning. AIM: The aim of our study is to report prevalence and correlates
      of current major depressive disorder (MDD) in the province of Granada, Southern
      Spain. METHODS: The GranadSigmap is a cross-sectional study based on a community
      dwelling adult population living in the province of Granada, Southern Spain.
      Community-dwelling adults aged 18-80 years ( n = 810) were interviewed using the
      Mini-International Neuropsychiatric Interview (MINI). A variety of exposure
      assessments were also undertaken. RESULTS: Point (2 weeks) prevalence of MDD in
      the Granada population was 5.6%. Positive family history of mental illness, high
      degree of neuroticism, high number of life threatening events (LTE), poor
      physical health status, cognitive impairment and cannabis use were independently
      associated with MDD in the multivariate regression model. Being female was also
      associated with MDD, but the significance disappeared after adjusting for
      neuroticism and physical health. CONCLUSION: Prevalence of MDD in the Granada
      population is higher than expected. The effects of the financial crisis could be
      partially accountable for this excess in prevalence. Six variables were found to
      be independently associated with MDD. Association between female sex and
      depression may be partially explained by the confounding effect of neuroticism.

PMID- 29843556
TI  - Assessing workload in neuropsychology: An illustration with the Tower of Hanoi
      test.
AB  - Workload is a common and useful construct in human factors research that has been
      largely overlooked in other areas of psychology, including neuropsychology, where
      it could be effectively employed both theoretically and practically. A popular
      subjective measure of workload, the NASA-Task Load Index (NASA-TLX), is
      illustrated with a computerized version of the Tower of Hanoi (TOH), a typical
      neuropsychological test of executive function. Reported workload, especially as
      an overall measure and also for the Mental Demand and Effort subscales, was
      greater in the more difficult TOH conditions and was positively correlated with
      number of moves to complete the TOH as well as completion time. Thus, results
      support the utility or construct validity of the NASA-TLX in reflecting workload
      states in the individual as well as various demands of the neuropsychological
      test (the timing, physical demands, etc.). It is argued that workload can be a
      useful construct in neuropsychological assessment, providing an additional
      channel of information on patient status. For instance, what does it mean if test
      performance for a patient is at a typical level (indicating no deficit) but
      workload is exceptionally high?

PMID- 29843557
TI  - Preparation of carbon nanofibers/tubes using waste tyres pyrolysis oil and coal
      fly ash derived catalyst.
AB  - In this study, two waste materials namely; coal fly ash (CFA) and waste tyres
      pyrolysis oil, were successfuly utilized in the synthesis of carbon
      nanofibers/tubes (CNF/Ts). In addition, Fe-rich CFA magnetic fraction (Mag-CFA)
      and ethylene gas were also used for comparison purposes. The carbons obtained
      from CFA were found to be anchored on the surface of the cenosphere and consisted
      of both CNTs and CNFs, whereas those obtained from Mag-CFA consisted of only
      multi-walled carbon nanotubes (MWCNTs). The study further showed that the type of
      carbon precursor and support material played an important role in determining the
      nanocarbon growth mechanism. The findings from this research have demonstrated
      that it is possible to utilize waste tyres pyrolysis oil vapor as a substitute
      for some expensive commercial carbonaceous gases.

PMID- 29843558
TI  - Neuroencorine Tumor Arising within a Tailgut Cyst in an Adolescent Boy.
AB  - INTRODUCTION: Neuroendocrine tumors (NET) within tailgut cysts (TC) are usually
      seen in middle-aged females. A 14 year-old boy who underwent surgical excision of
      NET within TC is presented to discuss the clinical features, diagnosis and
      treatment options. CASE REPORT: A 14-year-old boy with rectal bleeding and
      constipation had a 5 * 4 cm mass detected upon rectal examination. The cystic
      mass was totally excised. The histopathological evaluation revealed a low-grade
      NET within mucularis layer of the cyst showing a positive immunhistochemical
      staining for cytokeratin and synaptophysin. CONCLUSION: Although, the malignant
      transition of TC is commonly observed in middle age females, males and children
      can also be affected. This is first report of a pediatric TC with malignant
      transformation. Total surgical excision of cysts is mandatory for local control
      of the disease and chemotherapy should be reserved for the patients who have
      positive surgical margins.

PMID- 29843559
TI  - No consensus on physicians' preferences on vascular access management after
      kidney transplantation: Results of a multi-national survey.
AB  - OBJECTIVE: Arteriovenous fistulas for hemodialysis vascular access are a burden
      for the cardiovascular system. After successful kidney transplantation,
      prophylactic arteriovenous fistula ligation may improve cardiac outcomes;
      however, evidence is scarce. This survey investigates physicians' preference for
      management of arteriovenous fistulas and identifies the factors associated with
      preference for either arteriovenous fistula ligation or maintenance. MATERIALS
      AND METHODS: A survey was sent to members of eight national and international
      Nephrology and Vascular Surgery societies. The survey comprised eight case
      vignettes of asymptomatic patients with a functioning arteriovenous fistula after
      kidney transplantation. Characteristics possibly associated with treatment
      preferences were arteriovenous fistula flow, left ventricular ejection fraction,
      and patient age. Respondents were asked to state preference to maintain or ligate
      the arteriovenous fistula. Linear mixed-effects models were used to investigate
      the association of treatment preference with case characteristics. RESULTS: A
      total of 585 surveys were returned. A reduced left ventricular ejection fraction
      of 30% (beta 0.60, 95% confidence interval 0.55; 0.65) and a high flow of 2500
      mL/min (beta 0.46, 95% confidence interval 0.41; 0.51) were associated with a
      higher preference for arteriovenous fistula ligation. Disagreement among
      respondents was considerable, as in four out of eight cases less than 70% of
      respondents agreed on the arteriovenous fistula management strategy. CONCLUSION:
      Although respondents recognize a reduced left ventricular ejection fraction and a
      high flow as the risk factors, the high disagreement on management preferences
      suggests that evidence is inconclusive to recommend arteriovenous fistula
      ligation or maintenance after kidney transplantation. More research is needed to
      determine optimal arteriovenous fistula management after successful kidney
      transplantation.

PMID- 29843560
TI  - Anhedonia as a clinical correlate of inflammation in adolescents across
      psychiatric conditions.
AB  - OBJECTIVES: Peripheral inflammation has been associated with multiple psychiatric
      disorders, particularly with depression. However, findings remain inconsistent
      and unreproducible, most likely due to the disorder's heterogeneity in phenotypic
      presentation. Therefore, in the present study, in an effort to account for inter
      individual differences in symptom severity, we utilised a dimensional approach to
      assess the relationships between a broad panel of inflammatory cytokines and key
      psychiatric symptoms (i.e. depression, anhedonia, anxiety, fatigue and
      suicidality) in adolescents across psychiatric disorders. We hypothesised that
      only anhedonia (reflecting deficits of reward function) will be associated with
      inflammation. METHODS: Participants were 54 psychotropic medication-free
      adolescents with diverse psychiatric conditions and 22 healthy control (HC)
      adolescents, aged 12-20. We measured 41 cytokines after in vitro
      lipopolysaccharide stimulation. Mann-Whitney U and Spearman correlation tests
      examined group comparison and associations, respectively, while accounting for
      multiple comparisons and confounds, including depression severity adolescent.
      RESULTS: There were no group differences in cytokine levels. However, as
      hypothesised, within the psychiatric group, only anhedonia was associated with 19
      cytokines, including haematopoietic growth factors, chemokines, pro-inflammatory
      cytokines, and anti-inflammatory cytokines. CONCLUSIONS: Our findings suggest
      that general inflammation may induce reward dysfunction, which plays a salient
      role across psychiatric conditions, rather than be specific to one categorical
      psychiatric disorder.

PMID- 29843561
TI  - Spontaneous Ectopic Choroid Plexus with Sclerosis in Adult Beagle Dogs.
AB  - Microscopic examination of the brain of adult Beagle dogs from four different
      general toxicity studies revealed the presence of ectopic choroid plexus tissue
      in six individual dogs (4 females and 2 males) with ages ranging from 12 to 18
      months. In each dog, this finding was characterized by a well-circumscribed mass
      localized to a region above and along the corpus callosum without any apparent
      compression of adjacent brain tissue. Each mass was composed of columnar
      ependymal cells forming tubular structures surrounded by variable amounts of
      fibrovascular connective tissue and had the appearance of small rests of
      ependymal cells that had been penetrated by the leptomeninges during neural
      development. There were no associated clinical signs or macroscopic correlates.
      Based on morphologic appearance, a diagnosis of spontaneous ectopic choroid
      plexus with secondary sclerosis was made. To the authors' knowledge, ectopic
      choroid plexus has not been reported in Beagle dogs and is rare in humans and
      horses.

PMID- 29843562
TI  - Computational and experimental validation of morin as adenosine deaminase
      inhibitor.
AB  - Adenosine deaminase (ADA) is one of the major enzymes involved in purin
      metabolism, it has a significant role in cell growth and differentiation. Over
      activity of ADA has been noticed in some pathology, like malignancy and
      inflammation and makes it an attractive target for the development of drugs for
      such diseases. In the present study, ADA inhibitory activity of morin, a
      bioactive flavonoid, was assessed through computational and biophysical methods.
      The enzyme kinetics data showed that morin is a competitive inhibitor of ADA.
      Binding energy calculated from ITC analysis was -7.11 kcal/mol. Interaction of
      morin with ADA was also studied using fluorescence quenching method. Molecular
      docking studies revealed the structural details of the interaction. Molecular
      dynamics study in explicit solvent was also conducted to assess the structural
      stability of protein ligand complex.

PMID- 29843563
TI  - Subcritical water extraction of thyreostats from bovine muscle followed by liquid
      chromatography-tandem mass spectrometry.
AB  - Thyreostats can be used fraudulently to promote a rapid increase in weight of
      breeding animals at low cost. Their severe toxicological effects impose the
      development of reliable analytical methods to be used in monitoring plans. This
      work describes an alternative approach to isolate residues of thiouracil, methyl
      thiouracil, propyl-thiouracil, phenyl-thiouracil, tapazole and
      mercaptobenzimidazole from bovine muscle tissue. The developed procedure is based
      on the following three steps: i) matrix solid-phase dispersion with C18 for the
      preliminary sample preparation; ii) subcritical water extraction (SWE) at 160
      degrees C and 100 bar; iii) clean-up on an Oasis HLB cartridge. The quantitative
      determination was performed by LC-MS/MS in dual polarity ionization by using
      internal standardization. The SWE-LC-MS/MS method was validated according to the
      identification criteria of the Commission decision 2002/657/EC. The relative
      recoveries ranged from 72 to 97%; within-lab reproducibility was less than 18%.
      The decision limit and the detection capability of all analytes were below the
      recommended concentration, set at 10 ug kg-1, but the validation results
      demonstrated that this method could only be applied for screening of thiouracil
      and methyl-thiouracil. Besides the analytical advantages related to the use of
      water as solvent extraction, the procedure allowed significant removal of lipids,
      whose detrimental effects on instrumentation and MS sensitivity are well-known.

PMID- 29843564
TI  - Age-related changes in physical and perceptual markers of recovery following high
      intensity interval cycle exercise.
AB  - BACKGROUND: The purpose of this study was to compare physical performance,
      perceptual and haematological markers of recovery in well-trained masters and
      young cyclists across 48 h following a bout of repeated high-intensity interval
      exercise. METHODS: Nine masters (mean +/- SD; age = 55.6 +/- 5.0 years) and eight
      young (age = 25.9 +/- 3.0 years) cyclists performed a high-intensity interval
      exercise session consisting of 6 * 30 s intervals at 175% peak power output with
      4.5 min rest between efforts. Maximal voluntary contraction (MVC), 10 s sprint
      (10SST), 30-min time trial (30TT) performance, creatine kinase concentration (CK)
      and perceptual measures of motivation, total recovery, fatigue and muscle
      soreness were collected at baseline and at standardised time points across the 48
      h recovery period. RESULTS: No significant group-time interactions were observed
      for performance of MVC, 10SST, 30TT and CK (P > 0.05). A significant reduction in
      10SST peak power was found in both masters (P = 0.002) and young (P = 0.003)
      cyclists at 1 h post exercise, however, both groups physically recovered at
      similar rates. Neither group showed significant (P > 0.05) or practically
      meaningful increases in CK (%? < 10%). A significant age-related difference was
      found for perceptual fatigue (P = 0.01) and analysis of effect size (ES) showed
      that perceptual recovery was delayed with masters cyclists reporting lower
      motivation (ES +/-90%CI = 0.69 +/- 0.77, moderate), greater fatigue (ES = 0.75 +/
      0.93, moderate) and muscle soreness (ES = 0.61 +/- 0.70, moderate) after 48 h of
      recovery. CONCLUSION: The delay in perceived recovery may have negative effects
      on long-term participation to systematic training.

PMID- 29843565
TI  - A Schema of Denial: The Influence of Rape Myth Acceptance on Beliefs, Attitudes,
      and Processing of Affirmative Consent Campaign Messages.
AB  - This study aims to examine the influence of rape myth acceptance (RMA) and the
      perceived salience of sexual violence on the cognitive processing of an
      affirmative consent campaign active on the campus where research was conducted.
      As part of a midcourse evaluation of the Consent is Sexy (CIS) campaign (N =
      285), a subsample of participants who reported prior exposure to campaign posters
      (N = 182) was asked to review four campaign posters and indicate the extent to
      which they processed the message in the posters systematically. Robust gender
      differences in perceived salience of sexual violence, supportive attitudes, and
      perceived behavioral control (PBC) toward establishing consent were mediated by
      RMA. Moreover, robust gender differences in the systematic processing of the
      campaign were mediated by RMA and perceived salience in serial. Implications of
      the influence of rape myths and perceived salience on the cognitive processing of
      affirmed consent campaigns are discussed with respect to both campaign message
      design and implementation.

PMID- 29843566
TI  - Urinary aflatoxin exposure monitoring in rural and semi-urban populations in Ogun
      state, Nigeria.
AB  - Aflatoxins are a major class of fungal toxins that have food safety importance
      due to their economic and health impacts. This pilot aflatoxin exposure
      biomonitoring study on 84 individuals was conducted in a rural (Ilumafon) and a
      semi-urban community (Ilishan Remo) of Ogun state, Nigeria, to compare aflatoxin
      exposures among the two population cohorts. First morning urine samples were
      obtained from the participants, and the urinary aflatoxin M1 (AFM1) levels were
      measured by a quantitative Helica Biosystems Inc. ELISA kit assay. About 99% (83
      out of 84) of the urine samples had detectable AFM1 levels in the range of 0.06
      to 0.51 ng mL-1 (median: 0.27 ng mL-1). The mean urinary AFM1 levels were
      significantly (p = 0.001) higher in the semi-urban population (0.31 +/- 0.09 ng
      mL-1) compared to the rural population (0.24 +/- 0.07 ng mL-1). There were,
      however, no significant differences in mean urinary AFM1 levels of males and
      females, and among children, adolescents and adults. This study indicates high
      aflatoxin exposure to the extent of public health concerns in the studied
      populations. Thus, more efforts are required for aflatoxin exposure monitoring
      and control in high-risk regions.

PMID- 29843567
TI  - Practice Patterns of Fenestrated Aortic Aneurysm Repair: Nationwide Comparison of
      Z-Fen Adoption at Academic and Community Centers Since Commercial Availability.
AB  - CONTEXT: Over the past decade, a number of endovascular approaches have evolved
      to treat aortic aneurysms with anatomy that is not amenable to traditional
      endovascular repair, although the optimal practice and referral patterns remain
      in question. The Zenith fenestrated (Z-Fen) endograft (Cook Medical) represents
      the first commercially available fenestrated graft product in the United States.
      OBJECTIVE: We aim to quantify practice patterns in Z-Fen use during the first 5
      years of commercial availability, and we identify predictors of high and low
      uptake. DESIGN, SETTING, AND PATIENTS: This is a retrospective review of complete
      order records for Z-Fen endografts since June 2012. We performed univariate and
      multivariate regressions of predictors that surgeons and centers would be in the
      top and bottom quartiles of annual Z-Fen use. RESULTS: Since June 15, 2012, 744
      surgeons have been trained to use Z-Fen, and 4133 cases have been performed at
      409 trained centers. The average annual number of cases per trained surgeon was
      4.46 [95% confidence interval (CI), 3.58-5.70]; however, many surgeons performed
      few or no cases following training, and there was a skew toward users with low
      average annual volumes (25th percentile 1.23, 50th percentile 2.35, 75th
      percentile 4.93, and 99th percentile 33.29). Predictors of high annual use in the
      years following training included academic center (aOR 5.87, P = .001) and
      training within the first 2 years of availability (aOR 46.23, P < .001).
      CONCLUSION: While there is literature supporting the safety and efficacy of Z
      Fen, adoption has been relatively slow in an era when the vast majority of
      vascular surgeons have advanced endovascular skills. Given the training and
      resources required to use fenestrated or branched aortic endovascular devices,
      referral patterns should be determined and training should be focused on centers
      with high expected volumes.

PMID- 29843568
TI  - The status of research ethics in social work.
AB  - Research ethics provide important and necessary standards related to the conduct
      and dissemination of research. To better understand the current state of research
      ethics discourse in social work, a systematic literature search was undertaken
      and numbers of publications per year were compared between STEM, social science,
      and social work disciplines. While many professions have embraced the need for
      discipline-specific research ethics subfield development, social work has
      remained absent. Low publication numbers, compared to other disciplines, were
      noted for the years (2006-2016) included in the study. Social work published 16
      (1%) of the 1409 articles included in the study, contributing 3 (>1%) for each of
      the disciplines highest producing years (2011 and 2013). Comparatively,
      psychology produced 75 (5%) articles, psychiatry produced 64 (5%) articles, and
      nursing added 50 (4%) articles. The STEM disciplines contributed 956 (68%)
      articles between 2006 and 2016, while social science produced 453 (32%) articles.
      Examination of the results is provided in an extended discussion of several
      misconceptions about research ethics that may be found in the social work
      profession. Implications and future directions are provided, focusing on the need
      for increased engagement, education, research, and support for a new subfield of
      social work research ethics.

PMID- 29843569
TI  - Spironolactone in Combination with alpha-glycosyl Isoquercitrin Prevents
      Steatosis-related Early Hepatocarcinogenesis in Rats through the Observed NADPH
      Oxidase Modulation.
AB  - Administration of the diuretic, spironolactone (SR), can inhibit chronic liver
      diseases. We determined the effects of SR alone or in combination with the
      antioxidant alpha-glycosyl isoquercitrin (AGIQ) on hyperlipidemia- and steatosis
      related precancerous lesions in high-fat diet (HFD)-fed rats subjected to a two
      stage hepatocarcinogenesis model. Rats were fed with control basal diet or HFD,
      which was administered with SR alone or in combination with an antioxidant AGIQ
      in drinking water. An HFD increased body weight, intra-abdominal fat (adipose)
      tissue weight, and plasma lipids, which were reduced by coadministration of SR
      and AGIQ. SR and AGIQ coadministration also reduced hepatic steatosis and
      preneoplastic glutathione S-transferase placental form-positive foci, in
      association with decrease in NADPH oxidase (NOX) subunit p22phox-positive cells
      and an increase in active-caspase-3-positive cells in the foci. Hepatic gene
      expression analysis revealed that the coadministration of SR and AGIQ altered
      mRNA levels of lipogenic enzymes ( Scd1 and Fasn), antioxidant-related enzymes (
      Catalase), NOX component ( P67phox), and anti-inflammatory transcriptional factor
      ( Pparg). Our results indicated that SR in combination with AGIQ had the
      potential of suppressing hyperlipidemia- and steatosis-related early
      hepatocarcinogenesis through the reduced expression of NOX subunits.

PMID- 29843570
TI  - Body dissatisfaction in normal weight children - sports activities and motives
      for engaging in sports.
AB  - Body dissatisfaction is a phenomenon that may already occur in childhood and is
      linked to a variety of psychosocial risks. As the role of physical activity in
      the context of body dissatisfaction is still ambivalent, a cross-sectional study
      with 602 normal weight children (50.2% girls; Mage = 9.23 years; SD = 0.79) was
      conducted. The children filled in the MoMo-Questionnaire, including items about
      their physical activities and motives for being physically active, as well as
      Bender's Body Esteem and Muscularity Concern Scale with the three subscales "body
      satisfaction", "weight and shape concerns", and "muscularity concerns".
      Independent t-tests revealed that girls were less worried about muscularity than
      boys (Mgirls = 1.94, SDgirls = 1.11 vs. Mboys = 3.12, SDboys = 1.43; t(560) =
      11.33, p < .001, Cohen's d = 0.92), whereas girls showed greater weight and shape
      concerns than boys (Mgirls = 2.24, SDgirls = 0.97 vs. Mboys = 2.05, SDboys =
      0.92; t(549) = 2.32, p = .02, d = 0.20). In boys, physical activity is associated
      with less muscularity, weight, and shape concerns. Body satisfaction increases
      with health and fitness motives. In girls, the role of physical activity is
      ambivalent: girls who engage in sports do not differ in body dissatisfaction from
      non-active girls. In sportive girls, weight and shape concerns increased with
      more health and fitness motives. Finally, the study provides first insights into
      body dissatisfaction and the different role of physical activity in boys and
      girls in childhood.

PMID- 29843571
TI  - Formal volunteering as a protector of health in the context of social losses.
AB  - This study aims to examine the effect of the death of a family member or friend
      on psychological well-being, specifically the moderating effects of first-time
      volunteering and social network. With the sample of 354 volunteers from the
      Experience Corps(r) (EC) programs, Analysis of covariance (ANCOVA) estimated the
      differences in psychological well-being. Among volunteers who had experienced the
      death of a family member or friend, new volunteers showed significant improvement
      in positive affect compared to experienced volunteers. EC members gained
      additional social contacts through volunteering. Formal volunteering has a
      salutatory effect on older adults' health after the loss of family members.

PMID- 29843572
TI  - Dietary heavy metal exposure of Finnish children of 3 to 6 years.
AB  - The dietary exposure of Finnish 3-year-old and 6-year-old children to cadmium,
      lead, arsenic and mercury was determined using concentration data from Finland
      and individual food consumption data as well as individual weights of the
      children. Using middle bound estimates, 88% of the 3-year-olds and 64% of the 6
      year-olds exceeded the tolerable weekly intake of cadmium. The benchmark dose for
      neurological damage caused by lead was exceeded by 14% and 1%, while the lowest
      benchmark dose of inorganic arsenic was exceeded by 43% and 29% for the 3-year
      olds and 6-year-olds, respectively. The exposure of both age groups was below the
      tolerable weekly intake for inorganic mercury and methyl mercury. Although high,
      the exposures calculated with predominantly national concentration data were
      lower than previously estimated by EFSA, due to, for example, lower average
      concentrations in some much-consumed foods. The heavy metal exposure levels of
      the girls and the boys were also compared. Exposure to cadmium and lead was
      significantly higher for the boys than for the girls in both age groups, and
      exposure to inorganic arsenic was significantly higher for the 6-year-old boys
      than the girls of same age.

PMID- 29843573
TI  - Advance Directives Information Delivery in Medicare/Medicaid-Funded Agencies: An
      Exploratory Study.
AB  - To encourage citizens to plan their end-of-life care to protect their autonomy,
      Congress passed the Patient Self-Determination Act (PSDA) in 1990. Under the
      PSDA, all Medicare/Medicaid-funded agencies are required to ask if all the
      patients, upon admission, have advance directives (ADs). If they have not
      formulated an AD, agencies need to inform that they have a right to do so and
      provide them with the written information. Although this is required by law,
      there is no universal procedure or set standard approach to deliver the
      information to patients in these agencies. It is often unclear who provides and
      explains information on ADs, and what materials are provided. The purpose of this
      study was to understand the procedures and challenges presented in the delivery
      of information about ADs in agencies in response to the PSDA requirements. Using
      a case study approach, semi-structured interviews with personnel in nine agencies
      were analyzed and three overarching themes were identified: organizational
      procedures, staff interactions, and staff perceptions. The findings indicated
      that there is a need for AD-specific training for staff responsible for
      delivering AD information to their clients. Implementation of a formalized
      procedure/guidelines for information delivery would be helpful to maintain
      quality standards across agencies.

PMID- 29843574
TI  - Scientific and Regulatory Policy Committee Points to Consider: Data Visualization
      for Clinical and Anatomic Pathologists.
AB  - Assessment and communication of toxicology data are fundamental components of the
      work performed by veterinary anatomic and clinical pathologists involved in
      toxicology research. In recent years, there has been an evolution in the number
      and variety of software tools designed to facilitate the evaluation and
      presentation of toxicity study data. A working group of the Society of
      Toxicologic Pathology Scientific and Regulatory Policy Committee reviewed
      existing and emerging visualization technologies. This Points to Consider article
      reviews some of the currently available data visualization options, describes the
      utility of different types of graphical displays, and explores potential areas of
      controversy and ambiguity encountered with the use of these tools.

PMID- 29843575
TI  - Talaromyces borbonicus, sp. nov., a novel fungus from biodegraded Arundo donax
      with potential abilities in lignocellulose conversion.
AB  - A novel fungal species able to synthesize enzymes with potential synergistic
      actions in lignocellulose conversion was isolated from the biomass of Arundo
      donax during biodegradation under natural conditions in the Gussone Park of the
      Royal Palace of Portici (Naples, Italy). In this work, this species was subjected
      to morphological and phylogenetic analyses. Sequencing of its genome was
      performed, resulting in 28 scaffolds that were assembled into 27.05 Mb containing
      9744 predicted genes, among which 396 belong to carbohydrate-active enzyme
      (CAZyme)-encoding genes. Here we describe and illustrate this previously unknown
      species, which was named Talaromyces borbonicus, by a polyphasic approach
      combining phenotypic, physiological, and sequence data.

PMID- 29843576
TI  - Dietary intake of dioxins in Japan in 2016 with time trends since 1998.
AB  - Total diet samples collected from seven regions throughout Japan in 2016 were
      analysed for polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and
      dioxin-like polychlorinated biphenyls (DL-PCBs), known collectively as dioxins.
      This led to estimates of the latest dietary intake of these contaminants for the
      general Japanese population (>=1 year old). The average daily intake of dioxins
      for a person weighing 50 kg, calculated at non-detected congener concentrations
      assumed to be equal to zero, was estimated to be 0.54 pg TEQ (toxic equivalents)
      kg-1 body weight (bw) day-1. This value is well below the tolerable daily intake
      of 4 pg TEQ kg-1 bw day-1 for dioxins in Japan. The average intake was highest
      from fish and shellfish, followed by meat and eggs. The TEQ contribution of the
      fish and shellfish group to the total dietary TEQs was significant (89%). The DL
      PCBs accounted for about 67% of the dioxin intake. The latest dioxin intake level
      was compared with previous estimates from total diet study results obtained
      annually since 1998 to determine the time trends in the dietary intake of dioxins
      in Japan. Overall, the average dioxin intake appeared to be decreasing gradually
      during the period of study. The previous average intakes of dioxins ranged from
      0.58 to 1.9 pg TEQ kg-1 bw day-1. The latest average intake was the lowest since
      1998 and was about one-third of the average intake in 1998. This decreasing trend
      in the dietary intake of dioxins was mainly influenced by the decreased dioxin
      intakes from two food groups, fish and shellfish, and meat and eggs.

PMID- 29843577
TI  - Adjuvant Hormonal Therapy for Low-Grade Endometrial Stromal Sarcoma.
AB  - OBJECTIVE: To compare aromatase inhibitors (AIs) with progestins as adjuvant
      hormonal therapy(AHT) for low-grade endometrial stromal sarcomas (LGESSs).
      METHODS: We reviewed cases with LGESS at our institution from 1984 to 2017.
      Disease recurrence and recurrence-free survival (RFS) were assessed among
      patients who received AI, progestins, or no AHT. RESULTS: Among 39 patients with
      LGESS, 18 received progestins, 13 received AI, and 8 received no AHT. Thirty
      patients had stage I disease, and 9 had stage II to IV disease. All underwent
      hysterectomies. Disease recurred in 70% (7/10) of stage I patients who received
      no AHT, compared to 14.3% (1/7) receiving AI, and 7.7% (1/13) receiving
      progestins ( P = .003). Among stage I patients taking AI, mean RFS was 153.1
      months (95% confidence interval [CI]: 110-195.6) versus 306.2 months (95% CI:
      259.7-352.6) for progestin patients and 90.8 months (95% CI: 56.8-124.9) for
      those who received no AHT. In stage II to IV patients, mean RFS was 148.5 months
      (95% CI: 148.5-148.5) and 120.8 months (95% CI: 55.8-185.9) for the AI and
      progestin groups, respectively. All stage II to IV patients received AHT. Among
      stage I patients, median follow-up time for RFS was 159.1 months for progestin
      patients, 52.6 months for AI, and 53.1 months for those who received no AHT. Of
      this, 69% of stage I patients taking progestins reduced/stopped treatment
      prematurely due to side effects. None of the patients taking AI discontinued
      treatment early. CONCLUSION: Aromatase inhibitor is associated with longer RFS in
      patients with advanced LGESS, is better tolerated than progestins, and can be
      primary AHT for LGESS.

PMID- 29843578
TI  - Percutaneous Retrieval of IVC Filters With Struts Penetrating the Vertebral Body.
AB  - INTRODUCTION: Inferior vena cava (IVC) filter penetration of the caval wall is a
      well-documented complication. Less frequently, the struts of an IVC filter can
      penetrate a vertebral body that can lead to symptoms of abdominal pain. Vertebral
      penetration poses a management challenge, and characteristics for successful
      endovascular retrieval of such filters has not been reported. CASE DESCRIPTION:
      We present 2 cases of IVC filters with vertebral body penetration that were
      successfully retrieved through an endovascular approach. On preprocedure computed
      tomography, both patients had a small zone of osteolysis surrounding the
      penetrated struts into the vertebral body. The procedures were done via right
      internal jugular access using an Ensnare device. In one of the cases, the hangman
      technique was used to release the filter apex from the vessel wall. Both filters
      were able to be retrieved without using excessive force, follow-up venacavograms
      showed no sign of extravasation, and no postprocedure complications developed.
      DISCUSSION: Preprocedure CT imaging is essential prior to IVC filter removal if
      vertebral penetration is suspected. The zone of osteolysis seen around the struts
      in both cases are likely the result of constant cardiorespiratory motion of the
      filter. Based on the fact that in both cases the filter legs were able to be
      disengaged from the vertebral body without the use of excessive force, we
      hypothesize that if a zone of osteolysis surrounding the struts can be confirmed
      on preprocedural CT, the filter removal can be safely attempted by the standard
      percutaneous endovascular approach.

PMID- 29843579
TI  - The CD40/CD40L system regulates rat cerebral microvasculature after focal
      ischemia/reperfusion via the mTOR/S6K signaling pathway.
AB  - OBJECTIVE: The role of CD40/CD40 ligand (CD40L) in microvascular thrombosis is
      now widely accepted. However, the exact mechanisms linking the CD40/CD40L system
      and the soluble form of CD40L (sCD40L) with microvascular thrombosis are
      currently a topic of intensive research. The objective of this study was to
      assess the potential mechanisms in CD40/CD40L system-regulated microvascular
      thrombosis after focal ischemia/reperfusion (I/R). METHODS: Rats were subjected
      to 60-min transient middle cerebral artery occlusion (MCAO). The experiments were
      divided into three groups: sham operation, MCAO, and MCAO + CD40 antagonist.
      Dynamic changes of serum-free sCD40L levels for 0, 1, 3, 5, 6, and 12 h by ELISA
      detecting kit after focal I/R were observed, and the CD40 expression levels in
      both platelet surface and vascular endothelial cell surface were measured by flow
      cytometry and immunofluorescence, respectively. Cerebral infarct volume was
      analyzed 12 h after reperfusion. mTOR/S6K signaling was determined by Western
      blot. RESULTS: A comparison of thrombus formation between MCAO and CD40
      antagonist treatment rats revealed a role for CD40 and/or CD40L in the
      inflammation-enhanced thrombosis responses in both of the platelet and vascular
      endothelial cell. MCAO rats yielded an acceleration of thrombus formation that
      was accompanied by increased CD40 levels in serum. The brain infarction was
      significantly decreased in CD40 antagonist treatment group compared to MCAO model
      group. The mTOR/S6K signaling was activated in MACO model than that of CD40
      antagonist treatment group. CONCLUSIONS: Our findings indicate that CD40/CD40L
      system contributes to microvascular thrombosis and brain infarction induced by
      MCAO and reperfusion. The mTOR/S6K signaling pathway is involved in the
      regulation of cerebral microvasculature after focal I/R by CD40/CD40L.
      ABBREVIATIONS: AKT: protein kinase B; CD40L: CD40 ligand; CSF: cerebrospinal
      fluid; FITC: fluorescein isothiocyanate; I/R: ischemia/reperfusion; MCAO: middle
      cerebral artery occlusion; mTOR: mechanistic target of rapamycin; PE: P
      phycoerythrin; sCD40L: soluble form of CD40L; TNF-a: tumor necrosis factor-alpha;
      WT: wild type.

PMID- 29843580
TI  - Force Control Characteristics for Generation and Relaxation in the Lower Limb.
AB  - We investigated the characteristics for force generation and relaxation using
      graded isometric contractions of the knee extensors. Participants performed the
      following tasks as quickly and accurately as possible. For the force generation
      task, force was increased from 0% to 20%, 40% and 60% of the maximal voluntary
      force (MVF). For the force relaxation task, force was decreased from 60% to 40%,
      20% and 0%. The following parameters of the recorded force were calculated:
      error, time, and rate of force development. The error was consistently greater
      for force relaxation than generation. Reaction and adjustment times were
      independent of the tasks. The control strategy was markedly different for force
      relaxation and generation, this tendency was particularly evident for the lower
      limb compared to the upper limb.

PMID- 29843581
TI  - Factors that assist and hinder efforts towards recovery from eating disorders: A
      comparison of collegiate female athletes and non-athletes.
AB  - This study compared female intercollegiate athletes' and non-athletes'
      experiences of working towards recovery from an eating disorder. Participants (55
      athletes, 99 non-athletes) responded to open-ended questions about factors that
      influenced their progress towards recovery. Both subgroups reported that
      Supportive Relationships and Cognitive/Emotional Shifts were most helpful. The
      third most frequent helpful factor for athletes was Sport Performance Concerns,
      for non-athletes it was Treatment. Athletes' most frequent hindering factors were
      Negative Emotions/Cognitions, Sport Pressures, and Hurtful Modelling, while non
      athletes reported Negative Emotions/Cognitions, Lack of Support, and Hurtful
      Modelling. Sport-specific factors were among the most common themes in athletes'
      responses; therefore, athletes' recovery experiences and treatment needs appear
      unique.

PMID- 29843582
TI  - Molecular and morphological data validate the new combination of Lysurus
      sphaerocephalum from Argentina, with some additional records on Phallales
      (Agaricomycetes).
AB  - On the basis of morphological and molecular analysis of several specimens of
      Lysurus periphragmoides collected in Argentina, the examination of materials
      collected in the type locality of Simblum sphaerocephalum (nowadays known as L.
      periphragmoides), also collected in Argentina (Cordoba), and the examination of
      specimens of L. periphragmoides from the old world, we conclude that Argentinean
      and South American material identified and synonymized to L. periphragmoides by
      Dring in 1980 should be emended as L. sphaerocephalum. As this species lacks type
      material designated on its protologue, and there is no type material either, we
      propose a lectotype and an epitype for L. sphaerocephalum. On the basis of
      species descriptions found in literature, we constructed a table with relevant
      differences between these two species: L. periphragmoides and L. sphaerocephalum.
      We fully describe L. sphaerocephalum, including lecto- and epitypes, and its
      position within the Lysuraceae clade. This work also includes descriptions and
      images of Blumenavia rhacodes, Itajahya galericulata, L. cruciatus, and Phallus
      indusiatus from Argentina, with the aim of expanding our knowledge of their
      distribution ranges in the studied regions.

PMID- 29843583
TI  - The Undergraduate Training in Genomics (UTRIG) Initiative: early & active
      training for physicians in the genomic medicine era.
AB  - Genomic medicine is transforming patient care. However, the speed of development
      has left a knowledge gap between discovery and effective implementation into
      clinical practice. Since 2010, the Training Residents in Genomics (TRIG) Working
      Group has found success in building a rigorous genomics curriculum with
      implementation tools aimed at pathology residents in postgraduate training years
      1-4. Based on the TRIG model, the interprofessional Undergraduate Training in
      Genomics (UTRIG) Working Group was formed. Under the aegis of the Undergraduate
      Medical Educators Section of the Association of Pathology Chairs and
      representation from nine additional professional societies, UTRIG's collaborative
      goal is building medical student genomic literacy through development of a ready
      to-use genomics curriculum. Key elements to the UTRIG curriculum are expert
      consensus-driven objectives, active learning methods, rigorous assessment and
      integration.

PMID- 29843584
TI  - The Neural Correlates of Self-Regulatory Fatigability During Inhibitory Control
      of Eye Blinking.
AB  - The capacity to regulate urges is an important human characteristic associated
      with a range of social and health outcomes. Self-regulatory capacity has been
      postulated to have a limited reserve, which when depleted leads to failure. The
      authors aimed to investigate the neural correlates of self-regulatory
      fatigability. Functional MRI was used to detect brain activations in 19 right
      handed healthy subjects during inhibition of eye blinking, in a block design. The
      increase in number of blinks during blink inhibition from the first to the last
      block was used as covariate of interest. There was an increase in the number of
      eye blinks escaping inhibitory control across blink inhibition blocks, whereas
      there was no change in the number of eye blinks occurring during rest blocks.
      Inhibition of blinking activated a wide network bilaterally, including the
      inferior frontal gyrus, dorsolateral prefrontal cortex, dorsal anterior cingulate
      cortex, supplementary motor area, and caudate. Deteriorating performance was
      associated with activity in orbitofrontal cortex, ventromedial prefrontal cortex,
      rostroventral anterior cingulate cortex, precuneus, somatosensory, and parietal
      areas. As anticipated, effortful eye-blink control resulted in activation of
      prefrontal control areas and regions involved in urge and interoceptive
      processing. Worsening performance was associated with activations in brain areas
      involved in urge, as well as regions involved in motivational evaluation. These
      findings suggest that self-regulatory fatigability is associated with relatively
      less recruitment of prefrontal cortical regions involved in executive control.

PMID- 29843585
TI  - Huntington's Disease Gene Expansion Carriers Are Aware of Their Degree of Apathy.
AB  - Huntington's disease is characterized by motor and behavioral symptoms as well as
      cognitive decline. Apathy is a common behavioral symptom, and its severity is
      related to disease progression. It has been suggested that Huntington's disease
      gene expansion carriers (HDGECs) are unaware of the signs and symptoms of the
      disease, which may account for their own level of awareness of their apathy.
      Therefore, the authors investigated the level of agreement on the degree of
      apathy severity between HDGECs and their proxies by using a self-report
      questionnaire. A total of 109 REGISTRY participants (premotormanifest, N=31;
      early motormanifest, N=49; and late motormanifest, N=29) and their proxies
      completed the Apathy Evaluation Scale. The authors used the Wilcoxon signed-rank
      test to assess whether gene expansion carriers and their proxies agreed on apathy
      severity. Scores on the Apathy Evaluation Scale significantly increased from the
      early motormanifest stage to the late motormanifest stage. Premotormanifest
      carriers scored themselves significantly higher on the Apathy Evaluation Scale
      than their proxies, whereas no differences were found between all motormanifest
      carriers and their proxies. Apathy severity increases in the motormanifest stages
      of Huntington's disease. HDGECs can adequately assess their level of apathy on a
      self-report questionnaire. These results also suggest that slight changes in the
      degree of apathy among premotormanifest gene expansion carriers remain unnoticed
      by their proxies.

PMID- 29843586
TI  - Relationships Between Confabulations and Mental Time Travel in Alzheimer's
      Disease.
AB  - The authors assessed the relationship between confabulations in Alzheimer's
      disease and the ability to mentally travel in time to reexperience memories.
      Twenty-seven patients with Alzheimer's disease were administered evaluations of
      provoked confabulations, spontaneous confabulations, and mental time travel.
      Provoked and spontaneous confabulations were evaluated with questions probing
      personal and general knowledge and with a scale rated by nursing and medical
      staff. Mental time travel was assessed by asking patients to retrieve personal
      memories. After each memory, participants had to provide a "remember" response if
      they were able to retrieve the event with their encoding context or a "know"
      response if they knew that the event had occurred but were unable to recall any
      contextual details. Results showed significant negative correlations between
      confabulations and "remember" responses. These findings reflect a relationship
      between the occurrence of confabulations in patients with Alzheimer's disease and
      impairments in their ability to mentally project themselves in time when
      retrieving the context in which confabulated memories were originally encoded.

PMID- 29843587
TI  - Changes in sound-source localization for children with bilateral severe to
      profound hearing loss following simultaneous bilateral cochlear implantation.
AB  - BACKGROUND: Sound localization is a valuable skill that children can develop to
      some extent via bilateral cochlear implants (biCIs). However, little is known
      regarding the change that can be expected in sound-source localization accuracy
      (SLA) pre- and post-biCI for children with bilateral, severe-to-profound hearing
      impairment who spent their early years listening via bilateral hearing aids
      (biHAs). This study therefore aimed to prospectively assess SLA in a group of
      children before, and at one year after, receiving simultaneous biCIs. METHODS:
      Ten children aged 5-18 years were tested. SLA was assessed using loudspeakers
      positioned at -60, -30, 0, +30, and +60 degrees azimuth. Root mean square (RMS)
      errors and percentage correct scores were calculated. Changes in SLA were
      analysed via paired t-tests and potential relationships between hearing threshold
      levels (HTLs) and SLA via correlation analyses. Response distributions via biHAs
      and biCIs were examined via scatterplots. RESULTS: The mean within-subject
      changes in SLA were a significant improvement in RMS error of 11.9 degrees  (p <
      0.05) and in per cent correct by 21.5% (p < 0.05). Scatterplots demonstrated a
      trend towards better localization of sounds from 0 degrees  azimuth via biCIs
      compared to via biHAs. No significant associations were found between any
      measures of SLA and HTLs. CONCLUSIONS: The findings of the present study
      demonstrate that simultaneous biCIs lead to improved sound localization in
      children with bilateral, severe to profound sensorineural hearing loss who
      previously used biHAs. SLA via biHAs or biCIs could not be predicted from
      children's audiograms, and therefore should be measured directly.

PMID- 29843588
TI  - Recommending plant taxa for supporting on-site species identification.
AB  - BACKGROUND: Predicting a list of plant taxa most likely to be observed at a given
      geographical location and time is useful for many scenarios in biodiversity
      informatics. Since efficient plant species identification is impeded mainly by
      the large number of possible candidate species, providing a shortlist of likely
      candidates can help significantly expedite the task. Whereas species distribution
      models heavily rely on geo-referenced occurrence data, such information still
      remains largely unused for plant taxa identification tools. RESULTS: In this
      paper, we conduct a study on the feasibility of computing a ranked shortlist of
      plant taxa likely to be encountered by an observer in the field. We use the
      territory of Germany as case study with a total of 7.62M records of freely
      available plant presence-absence data and occurrence records for 2.7k plant taxa.
      We systematically study achievable recommendation quality based on two types of
      source data: binary presence-absence data and individual occurrence records.
      Furthermore, we study strategies for aggregating records into a taxa
      recommendation based on location and date of an observation. CONCLUSION: We
      evaluate recommendations using 28k geo-referenced and taxa-labeled plant images
      hosted on the Flickr website as an independent test dataset. Relying on location
      information from presence-absence data alone results in an average recall of 82%.
      However, we find that occurrence records are complementary to presence-absence
      data and using both in combination yields considerably higher recall of 96% along
      with improved ranking metrics. Ultimately, by reducing the list of candidate taxa
      by an average of 62%, a spatio-temporal prior can substantially expedite the
      overall identification problem.

PMID- 29843589
TI  - RnaSeqSampleSize: real data based sample size estimation for RNA sequencing.
AB  - BACKGROUND: One of the most important and often neglected components of a
      successful RNA sequencing (RNA-Seq) experiment is sample size estimation. A few
      negative binomial model-based methods have been developed to estimate sample size
      based on the parameters of a single gene. However, thousands of genes are
      quantified and tested for differential expression simultaneously in RNA-Seq
      experiments. Thus, additional issues should be carefully addressed, including the
      false discovery rate for multiple statistic tests, widely distributed read counts
      and dispersions for different genes. RESULTS: To solve these issues, we developed
      a sample size and power estimation method named RnaSeqSampleSize, based on the
      distributions of gene average read counts and dispersions estimated from real RNA
      seq data. Datasets from previous, similar experiments such as the Cancer Genome
      Atlas (TCGA) can be used as a point of reference. Read counts and their
      dispersions were estimated from the reference's distribution; using that
      information, we estimated and summarized the power and sample size.
      RnaSeqSampleSize is implemented in R language and can be installed from
      Bioconductor website. A user friendly web graphic interface is provided at
      http://cqs.mc.vanderbilt.edu/shiny/RnaSeqSampleSize/ . CONCLUSIONS:
      RnaSeqSampleSize provides a convenient and powerful way for power and sample size
      estimation for an RNAseq experiment. It is also equipped with several unique
      features, including estimation for interested genes or pathway, power curve
      visualization, and parameter optimization.

PMID- 29843590
TI  - SemaTyP: a knowledge graph based literature mining method for drug discovery.
AB  - BACKGROUND: Drug discovery is the process through which potential new medicines
      are identified. High-throughput screening and computer-aided drug
      discovery/design are the two main drug discovery methods for now, which have
      successfully discovered a series of drugs. However, development of new drugs is
      still an extremely time-consuming and expensive process. Biomedical literature
      contains important clues for the identification of potential treatments. It could
      support experts in biomedicine on their way towards new discoveries. METHODS:
      Here, we propose a biomedical knowledge graph-based drug discovery method called
      SemaTyP, which discovers candidate drugs for diseases by mining published
      biomedical literature. We first construct a biomedical knowledge graph with the
      relations extracted from biomedical abstracts, then a logistic regression model
      is trained by learning the semantic types of paths of known drug therapies'
      existing in the biomedical knowledge graph, finally the learned model is used to
      discover drug therapies for new diseases. RESULTS: The experimental results show
      that our method could not only effectively discover new drug therapies for new
      diseases, but also could provide the potential mechanism of action of the
      candidate drugs. CONCLUSIONS: In this paper we propose a novel knowledge graph
      based literature mining method for drug discovery. It could be a supplementary
      method for current drug discovery methods.

PMID- 29843591
TI  - Correction to: Mandibulate convergence in an armoured Cambrian stem chelicerate.
AB  - The original article [1] had 4 paragraphs which contained erroneous information.
      In this correction article the correct and incorrect information is shown.

PMID- 29843592
TI  - Diversity and signature of small RNA in different bodily fluids using next
      generation sequencing.
AB  - BACKGROUND: Small RNAs are critical components in regulating various cellular
      pathways. These molecules may be tissue-associated or circulating in bodily
      fluids and have been shown to associate with different tumors. Next generation
      sequencing (NGS) on small RNAs is a powerful tool for profiling and discovery of
      microRNAs (miRNAs). RESULTS: In this study, we isolated total RNA from various
      bodily fluids: blood, leukocytes, serum, plasma, saliva, cell-free saliva, urine
      and cell-free urine. Next, we used Illumina's NGS platform and intensive
      bioinformatics analysis to investigate the distribution and signature of small
      RNAs in the various fluids. Successful NGS was accomplished despite the
      variations in RNA concentrations among the different fluids. Among the fluids
      studied, blood and plasma were found to be the most promising fluids for small
      RNA profiling as well as novel miRNA prediction. Saliva and urine yielded lower
      numbers of identifiable molecules and therefore were less reliable in small RNA
      profiling and less useful in predicting novel molecules. In addition, all fluids
      shared many molecules, including 139 miRNAs, the most abundant tRNAs, and the
      most abundant piwi-interacting RNAs (piRNAs). Fluids of similar origin (blood,
      urine or saliva) displayed closer clustering, while each fluid still retains its
      own characteristic signature based on its unique molecules and its levels of the
      common molecules. Donor urine samples showed sex-dependent differential
      clustering, which may prove useful for future studies. CONCLUSIONS: This study
      shows the successful clustering and unique signatures of bodily fluids based on
      their miRNA, tRNA and piRNA content. With this information, cohorts may be
      differentiated based on multiple molecules from each small RNA class by a
      multidimensional assessment of the overall molecular signature.

PMID- 29843593
TI  - Identification and analysis of ribosome-associated lncRNAs using ribosome
      profiling data.
AB  - BACKGROUND: Although the number of discovered long non-coding RNAs (lncRNAs) has
      increased dramatically, their biological roles have not been established. Many
      recent studies have used ribosome profiling data to assess the protein-coding
      capacity of lncRNAs. However, very little work has been done to identify ribosome
      associated lncRNAs, here defined as lncRNAs interacting with ribosomes related to
      protein synthesis as well as other unclear biological functions. RESULTS: On
      average, 39.17% of expressed lncRNAs were observed to interact with ribosomes in
      human and 48.16% in mouse. We developed the ribosomal association index (RAI),
      which quantifies the evidence for ribosomal associability of lncRNAs over various
      tissues and cell types, to catalog 691 and 409 lncRNAs that are robustly
      associated with ribosomes in human and mouse, respectively. Moreover, we
      identified 78 and 42 lncRNAs with a high probability of coding peptides in human
      and mouse, respectively. Compared with ribosome-free lncRNAs, ribosome-associated
      lncRNAs were observed to be more likely to be located in the cytoplasm and more
      sensitive to nonsense-mediated decay. CONCLUSION: Our results suggest that RAI
      can be used as an integrative and evidence-based tool for distinguishing between
      ribosome-associated and free lncRNAs, providing a valuable resource for the study
      of lncRNA functions.

PMID- 29843594
TI  - The effects of repeated whole genome duplication events on the evolution of
      cytokinin signaling pathway.
AB  - BACKGROUND: It is thought that after whole-genome duplications (WGDs), a large
      fraction of the duplicated gene copies is lost over time while few duplicates are
      retained. Which factors promote survival or death of a duplicate remains unclear
      and the underlying mechanisms are poorly understood. According to the model of
      gene dosage balance, genes encoding interacting proteins are predicted to be
      preferentially co-retained after WGDs. Among these are genes encoding proteins
      involved in complexes or in signal transduction. RESULTS: We have investigated
      the way that repeated WGDs during land plant evolution have affected cytokinin
      signaling to study patterns of gene duplicability and co-retention in this
      important signal transduction pathway. Through the integration of phylogenetic
      analyses with comparisons of genome collinearity, we have found that signal input
      mediated by cytokinin receptors proved to be highly conserved over long
      evolutionary time-scales, with receptors showing predominantly gene loss after
      repeated WGDs. However, the downstream elements, e,g. response regulators, were
      mainly retained after WGDs and thereby formed gene families in most plant
      lineages. CONCLUSIONS: Gene dosage balance between the interacting components
      indicated by co-retention after WGDs seems to play a minor role in the evolution
      of cytokinin signaling pathway. Overall, core genes of cytokinin signaling show a
      highly heterogeneous pattern of gene retention after WGD, reflecting complex
      relationships between the various factors that shape the long-term fate of a
      duplicated gene.

PMID- 29843595
TI  - Comparative expression analysis identifies the respiratory transition-related
      miRNAs and their target genes in tissues of metamorphosing Chinese giant
      salamander (Andrias davidianus).
AB  - BACKGROUND: Chinese giant salamander (Andrias davidianus) undergoes a
      metamorphosis from aquatic larvae to terrestrial adults, with concomitant
      transfer of respiration from gills to lungs prior to metamorphosis. These two
      tissues, as well as skin, were sampled to identify the differentially expressed
      miRNAs. RESULTS: High-coverage reference transcriptome was generated from
      combined gill, lung and skin tissues of metamorphosing juveniles, and lung tissue
      of adults: 86,282 unigenes with total length of approximately 77,275,634 bp and
      N50 of 1732 bp were obtained. Among these, 13,246 unigenes were assigned to 288
      pathways. To determine the possible involvement of miRNAs in the respiratory
      transition, small RNA libraries were sequenced; 282 miRNAs were identified, 65
      among which were known and 217 novel. Based on the hierarchical clustering
      analysis, the twelve studied samples were classified into three major clusters
      using differentially expressed miRNAs. We have validated ten differentially
      expressed miRNAs and some of their related target genes using qPCR. These results
      largely corroborated the results of transcriptomic and miRNA analyses. Finally,
      an miRNA-gene-network was constructed. Among them, two miRNAs with target genes
      related to oxygen sensing were differentially expressed between gill and lung
      tissues. Three miRNAs were differentially expressed between the lungs of larvae
      and lungs of adults. CONCLUSIONS: This study provides the first large-scale miRNA
      expression profile overview during the respiration transition from gills to lungs
      in Chinese giant salamander. Five differentially expressed miRNAs and their
      target genes were identified among skin, gill and lung tissues. These results
      suggest that miRNA profiles in respiratory tissues play an important role in the
      regulation of respiratory transition.

PMID- 29843596
TI  - Association genetics studies on frost tolerance in wheat (Triticum aestivum L.)
      reveal new highly conserved amino acid substitutions in CBF-A3, CBF-A15, VRN3 and
      PPD1 genes.
AB  - BACKGROUND: Understanding the genetic basis of frost tolerance (FT) in wheat
      (Triticum aestivum L.) is essential for preventing yield losses caused by frost
      due to cellular damage, dehydration and reduced metabolism. FT is a complex trait
      regulated by a number of genes and several gene families. Availability of the
      wheat genomic sequence opens new opportunities for exploring candidate genes
      diversity for FT. Therefore, the objectives of this study were to identity SNPs
      and insertion-deletion (indels) in genes known to be involved in frost tolerance
      and to perform association genetics analysis of respective SNPs and indels on FT.
      RESULTS: Here we report on the sequence analysis of 19 candidate genes for FT in
      wheat assembled using the Chinese Spring IWGSC RefSeq v1.0. Out of these, the
      tandem duplicated C-repeat binding factors (CBF), i.e. CBF-A3, CBF-A5, CBF-A10,
      CBF-A13, CBF-A14, CBF-A15, CBF-A18, the vernalisation response gene VRN-A1, VRN
      B3, the photoperiod response genes PPD-B1 and PPD-D1 revealed association to FT
      in 235 wheat cultivars. Within six genes (CBF-A3, CBF-A15, VRN-A1, VRN-B3, PPD-B1
      and PPD-D1) amino acid (AA) substitutions in important protein domains were
      identified. The amino acid substitution effect in VRN-A1 on FT was confirmed and
      new AA substitutions in CBF-A3, CBF-A15, VRN-B3, PPD-B1 and PPD-D1 located at
      highly conserved sites were detected. Since these results rely on phenotypic data
      obtained at five locations in 2 years, detection of significant associations of
      FT to AA changes in CBF-A3, CBF-A15, VRN-A1, VRN-B3, PPD-B1 and PPD-D1 may be
      exploited in marker assisted breeding for frost tolerance in winter wheat.
      CONCLUSIONS: A set of 65 primer pairs for the genes mentioned above from a
      previous study was BLASTed against the IWGSC RefSeq resulting in the
      identification of 39 primer combinations covering the full length of 19 genes.
      This work demonstrates the usefulness of the IWGSC RefSeq in specific primer
      development for highly conserved gene families in hexaploid wheat and, that a
      candidate gene association genetics approach based on the sequence data is an
      efficient tool to identify new alleles of genes important for the response to
      abiotic stress in wheat.

PMID- 29843597
TI  - Understanding the regulatory mechanisms of milk production using integrative
      transcriptomic and proteomic analyses: improving inefficient utilization of crop
      by-products as forage in dairy industry.
AB  - BACKGROUND: Bovine milk is an important nutrient source for humans. Forage plays
      a vital role in dairy husbandry via affecting milk quality and quantity. However,
      the differences in mammary metabolism of dairy cows fed different forages remain
      elucidated. In this study, we utilized transcriptomic RNA-seq and iTRAQ proteomic
      techniques to investigate and integrate the differences of molecular pathways and
      biological processes in the mammary tissues collected from 12 lactating cows fed
      corn stover (CS, low-quality, n = 6) and alfalfa hay (AH, high-quality, n = 6).
      RESULTS: A total of 1631 differentially expressed genes (DEGs; 1046 up-regulated
      and 585 down-regulated) and 346 differentially expressed proteins (DEPs; 138
      increased and 208 decreased) were detected in the mammary glands between the CS-
      and AH-fed animals. Expression patterns of 33 DEPs (18 increased and 15
      decreased) were consistent with the expression of their mRNAs. Compared with the
      mammary gland of AH-fed cows, the marked expression changes found in the mammary
      gland of CS group were for genes involved in reduced mammary growth/development
      (COL4A2, MAPK3, IKBKB, LGALS3), less oxidative phosphorylation (ATPsynGL,
      ATP6VOA1, ATP5H, ATP6VOD1, NDUFC1), enhanced lipid uptake/metabolism (SLC27A6,
      FABP4, SOD2, ACADM, ACAT1, IDH1, SCP2, ECHDC1), more active fatty acid beta
      oxidation (HMGCS1), less amino acid/protein transport (SLC38A2, SLC7A8, RAB5a,
      VPS18), reduced protein translation (RPS6, RPS12, RPS16, RPS19, RPS20, RPS27),
      more proteasome- (PSMC2, PSMC6, PSMD14, PSMA2, PSMA3) and ubiquitin-mediated
      protein degradation (UBE2B, UBE2H, KLHL9, HSPH1, DNAJA1 and CACYBP), and more
      protein disassembly-related enzymes (SEC63, DNAJC3, DNAJB1, DNAJB11 and DNAJC12).
      CONCLUSION: Our results indicate that the lower milk production in the CS-fed
      dairy cows compared with the AH-fed cows was associated with a network of mammary
      gene expression changes, importantly, the prime factors include decreased energy
      metabolism, attenuated protein synthesis, enhanced protein degradation, and the
      lower mammary cell growth. The present study provides insights into the effects
      of the varying quality of forages on mammary metabolisms, which can help the
      improvement of strategies in feeding dairy cows with CS-based diet.

PMID- 29843599
TI  - JCDSA: a joint covariate detection tool for survival analysis on tumor expression
      profiles.
AB  - BACKGROUND: Survival analysis on tumor expression profiles has always been a key
      issue for subsequent biological experimental validation. It is crucial how to
      select features which closely correspond to survival time. Furthermore, it is
      important how to select features which best discriminate between low-risk and
      high-risk group of patients. Common features derived from the two aspects may
      provide variable candidates for prognosis of cancer. RESULTS: Based on the
      provided two-step feature selection strategy, we develop a joint covariate
      detection tool for survival analysis on tumor expression profiles. Significant
      features, which are not only consistent with survival time but also associated
      with the categories of patients with different survival risks, are chosen. Using
      the miRNA expression data (Level 3) of 548 patients with glioblastoma multiforme
      (GBM) as an example, miRNA candidates for prognosis of cancer are selected. The
      reliability of selected miRNAs using this tool is demonstrated by 100
      simulations. Furthermore, It is discovered that significant covariates are not
      directly composed of individually significant variables. CONCLUSIONS: Joint
      covariate detection provides a viewpoint for selecting variables which are not
      individually but jointly significant. Besides, it helps to select features which
      are not only consistent with survival time but also associated with prognosis
      risk. The software is available at http://bio-nefu.com/resource/jcdsa .

PMID- 29843598
TI  - Cryptic Plutella species show deep divergence despite the capacity to hybridize.
AB  - BACKGROUND: Understanding genomic and phenotypic diversity among cryptic pest
      taxa has important implications for the management of pests and diseases. The
      diamondback moth, Plutella xylostella L., has been intensively studied due to its
      ability to evolve insecticide resistance and status as the world's most
      destructive pest of brassicaceous crops. The surprise discovery of a cryptic
      species endemic to Australia, Plutella australiana Landry & Hebert, raised
      questions regarding the distribution, ecological traits and pest status of the
      two species, the capacity for gene flow and whether specific management was
      required. Here, we collected Plutella from wild and cultivated brassicaceous
      plants from 75 locations throughout Australia and screened 1447 individuals to
      identify mtDNA lineages and Wolbachia infections. We genotyped genome-wide SNP
      markers using RADseq in coexisting populations of each species. In addition, we
      assessed reproductive compatibility in crossing experiments and insecticide
      susceptibility phenotypes using bioassays. RESULTS: The two Plutella species
      coexisted on wild brassicas and canola crops, but only 10% of Plutella
      individuals were P. australiana. This species was not found on commercial
      Brassica vegetable crops, which are routinely sprayed with insecticides.
      Bioassays found that P. australiana was 19-306 fold more susceptible to four
      commonly-used insecticides than P. xylostella. Laboratory crosses revealed that
      reproductive isolation was incomplete but directionally asymmetric between the
      species. However, genome-wide nuclear SNPs revealed striking differences in
      genetic diversity and strong population structure between coexisting wild
      populations of each species. Nuclear diversity was 1.5-fold higher in P.
      australiana, yet both species showed limited variation in mtDNA. Infection with a
      single Wolbachia subgroup B strain was fixed in P. australiana, suggesting that a
      selective sweep contributed to low mtDNA diversity, while a subgroup A strain
      infected just 1.5% of P. xylostella. CONCLUSIONS: Despite sympatric distributions
      and the capacity to hybridize, strong genomic and phenotypic divergence exists
      between these Plutella species that is consistent with contrasting colonization
      histories and reproductive isolation after secondary contact. Although P.
      australiana is a potential pest of brassicaceous crops, it is of secondary
      importance to P. xylostella.

PMID- 29843600
TI  - Study of spontaneous mutations in the transmission of poplar chloroplast genomes
      from mother to offspring.
AB  - BACKGROUND: Chloroplasts have their own genomes, independent from nuclear
      genomes, that play vital roles in growth, which is a major targeted trait for
      genetic improvement in Populus. Angiosperm chloroplast genomes are maternally
      inherited, but the chloroplast' variation pattern of poplar at the single-base
      level during the transmission from mother to offspring remains unknown. RESULTS:
      Here, we constructed high-quality and almost complete chloroplast genomes for
      three poplar clones, 'NL895' and its parents, 'I69' and 'I45', from the short
      read datasets using multi-pass sequencing (15-16 times per clone) and ultra-high
      coverage (at least 8500* per clone), with the four-step strategy of Simulation
      Assembly-Merging-Correction. Each of the three resulting chloroplast assemblies
      contained contigs covering > 99% of Populus trichocarpa chloroplast DNA as a
      reference. A total of 401 variant loci were identified by a hybrid strategy of
      genome comparison-based and mapping-based single nucleotide polymorphism calling.
      The genotypes of 94 variant loci were different among the three poplar clones.
      However, only 1 of the 94 loci was a missense mutation, which was located in the
      exon region of rpoC1 encoding the beta' subunit of plastid-encoded RNA
      polymerase. The genotype of the loci in NL895 and its female parent (I69) was
      different from that of its male parent (I45). CONCLUSIONS: This research provides
      resources for further chloroplast genomic studies of a F1 full-sibling family
      derived from a cross between I69 and I45, and will improve the application of
      chloroplast genomic information in modern Populus breeding programs.

PMID- 29843601
TI  - Genomic prediction of crown rust resistance in Lolium perenne.
AB  - BACKGROUND: Genomic selection (GS) can accelerate genetic gains in breeding
      programmes by reducing the time it takes to complete a cycle of selection.
      Puccinia coronata f. sp lolli (crown rust) is one of the most widespread diseases
      of perennial ryegrass and can lead to reductions in yield, persistency and
      nutritional value. Here, we used a large perennial ryegrass population to assess
      the accuracy of using genome wide markers to predict crown rust resistance and to
      investigate the factors affecting predictive ability. RESULTS: Using these data,
      predictive ability for crown rust resistance in the complete population reached a
      maximum of 0.52. Much of the predictive ability resulted from the ability of
      markers to capture genetic relationships among families within the training set,
      and reducing the marker density had little impact on predictive ability. Using
      permutation based variable importance measure and genome wide association studies
      (GWAS) to identify and rank markers enabled the identification of a small subset
      of SNPs that could achieve predictive abilities close to those achieved using the
      complete marker set. CONCLUSION: Using a GWAS to identify and rank markers
      enabled a small panel of markers to be identified that could achieve higher
      predictive ability than the same number of randomly selected markers, and
      predictive abilities close to those achieved with the entire marker set. This was
      particularly evident in a sub-population characterised by having on-average
      higher genome-wide linkage disequilibirum (LD). Higher predictive abilities with
      selected markers over random markers suggests they are in LD with QTL. Accuracy
      due to genetic relationships will decay rapidly over generations whereas accuracy
      due to LD will persist, which is advantageous for practical breeding
      applications.

PMID- 29843602
TI  - Combining RNA-seq data and homology-based gene prediction for plants, animals and
      fungi.
AB  - BACKGROUND: Genome annotation is of key importance in many research questions.
      The identification of protein-coding genes is often based on transcriptome
      sequencing data, ab-initio or homology-based prediction. Recently, it was
      demonstrated that intron position conservation improves homology-based gene
      prediction, and that experimental data improves ab-initio gene prediction.
      RESULTS: Here, we present an extension of the gene prediction program GeMoMa that
      utilizes amino acid sequence conservation, intron position conservation and
      optionally RNA-seq data for homology-based gene prediction. We show on published
      benchmark data for plants, animals and fungi that GeMoMa performs better than the
      gene prediction programs BRAKER1, MAKER2, and CodingQuarry, and purely RNA-seq
      based pipelines for transcript identification. In addition, we demonstrate that
      using multiple reference organisms may help to further improve the performance of
      GeMoMa. Finally, we apply GeMoMa to four nematode species and to the recently
      published barley reference genome indicating that current annotations of protein
      coding genes may be refined using GeMoMa predictions. CONCLUSIONS: GeMoMa might
      be of great utility for annotating newly sequenced genomes but also for finding
      homologs of a specific gene or gene family. GeMoMa has been published under GNU
      GPL3 and is freely available at http://www.jstacs.de/index.php/GeMoMa .

PMID- 29843603
TI  - Genome-wide association study reveals a QTL and strong candidate genes for
      umbilical hernia in pigs on SSC14.
AB  - BACKGROUND: Umbilical hernia is one of the most prevalent congenital defect in
      pigs, causing economic losses and substantial animal welfare problems.
      Identification and implementation of genomic regions controlling umbilical hernia
      in breeding is of great interest to reduce incidences of hernia in commercial pig
      production. The aim of this study was to identify such regions and possibly
      identify causative variation affecting umbilical hernia in pigs. A case/control
      material consisting of 739 Norwegian Landrace pigs was collected and applied in a
      GWAS study with a genome-wide distributed panel of 60 K SNPs. Additionally
      candidate genes were sequenced to detect additional polymorphisms that were used
      for single SNP and haplotype association analyses in 453 of the pigs. RESULTS:
      The GWAS in this report detected a highly significant region affecting umbilical
      hernia around 50 Mb on SSC14 (P < 0.0001) explaining up to 8.6% of the phenotypic
      variance of the trait. The region is rather broad and includes 62 significant
      SNPs in high linkage disequilibrium with each other. Targeted sequencing of
      candidate genes within the region revealed polymorphisms within the Leukemia
      inhibitory factor (LIF) and Oncostatin M (OSM) that were significantly associated
      with umbilical hernia (P < 0.001). CONCLUSIONS: A highly significant QTL for
      umbilical hernia in Norwegian Landrace pigs was detected around 50 Mb on SSC14.
      Resequencing of candidate genes within the region revealed SNPs within LIF and
      OSM highly associated with the trait. However, because of extended LD within the
      region, studies in other populations and functional studies are needed to
      determine whether these variants are causal or not. Still without this knowledge,
      SNPs within the region can be used as genetic markers to reduce incidences of
      umbilical hernia in Norwegian Landrace pigs.

PMID- 29843604
TI  - TSVdb: a web-tool for TCGA splicing variants analysis.
AB  - BACKGROUND: Collaborative projects such as The Cancer Genome Atlas (TCGA) have
      generated various -omics and clinical data on cancer. Many computational tools
      have been developed to facilitate the study of the molecular characterization of
      tumors using data from the TCGA. Alternative splicing of a gene produces splicing
      variants, and accumulating evidence has revealed its essential role in cancer
      related processes, implying the urgent need to discover tumor-specific isoforms
      and uncover their potential functions in tumorigenesis. RESULT: We developed
      TSVdb, a web-based tool, to explore alternative splicing based on TCGA samples
      with 30 clinical variables from 33 tumors. TSVdb has an integrated and well
      proportioned interface for visualization of the clinical data, gene expression,
      usage of exons/junctions and splicing patterns. Researchers can interpret the
      isoform expression variations between or across clinical subgroups and estimate
      the relationships between isoforms and patient prognosis. TSVdb is available at
      http://www.tsvdb.com , and the source code is available at
      https://github.com/wenjie1991/TSVdb . CONCLUSION: TSVdb will inspire oncologists
      and accelerate isoform-level advances in cancer research.

PMID- 29843605
TI  - DnaJ homolog subfamily A member1 (DnaJ1) is a newly discovered anti-apoptotic
      protein regulated by azadirachtin in Sf9 cells.
AB  - BACKGROUND: Azadirachtin, one of the most promising botanical insecticides, has
      been widely used for pest control. Azadirachtin induces apoptosis in insect cell
      lines, including Sf9, SL-1 and BTI-Tn-5B1-4. Mitochondrial and lysosomal pathways
      are likely involved in the azadirachtin-induced apoptosis, however, detailed
      molecular mechanisms remain largely undefined. RESULTS: Azadirachtin-induced
      apoptosis in Sf9 cells was verified by morphological observation, Hoechst 33258
      staining, and a Caspase-3-based analysis. Comparative two-dimensional gel
      electrophoresis (2-DE) coupled with a linear ion trap quadrupole (LTQ)-MS/MS
      analysis identified 12 prominent, differentially expressed proteins following
      azadirachtin treatment. These differentially expressed genes are involved in
      regulating cytoskeleton development, signal transduction, gene transcription, and
      cellular metabolism. Knockdown gene expression of a gene encoding a DnaJ homolog
      enhanced apoptosis induced by azadirachtin in Sf9 cells. CONCLUSION: Azadirachtin
      treatment induces apoptosis in Sf9 cells and affects expression of multiple genes
      with functions in cytoskeleton development, signal transduction, gene regulation,
      and cellular metabolisms. Azadirachtin induces apoptosis at least partially by
      down-regulation of Sf-DnaJ in Sf9 cells.

PMID- 29843606
TI  - Landscape of copy number variations in Bos taurus: individual - and inter-breed
      variability.
AB  - BACKGROUND: The number of studies of Copy Number Variation in cattle has
      increased in recent years. This has been prompted by the increased availability
      of data on polymorphisms and their relationship with phenotypes. In addition,
      livestock species are good models for some human phenotypes. In the present
      study, we described the landscape of CNV driven genetic variation in a large
      population of 146 individuals representing 13 cattle breeds, using whole genome
      DNA sequence. RESULTS: A highly significant variation among all individuals and
      within each breed was observed in the number of duplications (P < 10-15) and in
      the number of deletions (P < 10-15). We also observed significant differences
      between breeds for duplication (P = 0.01932) and deletion (P = 0.01006) counts.
      The same variation CNV length - inter-individual and inter-breed differences were
      significant for duplications (P < 10-15) and deletions (P < 10-15). Moreover,
      breed-specific variants were identified, with the largest proportion of breed
      specific duplications (9.57%) found for Fleckvieh and breed-specific deletions
      found for Brown Swiss (5.00%). Such breed-specific CNVs were predominantly
      located in intragenic regions, however in Simmental, one deletion present in five
      individuals was found in the coding sequence of a novel gene ENSBTAG00000000688
      on chromosome 18. In Brown Swiss, Norwegian Red and Simmental breed-specific
      deletions were located within KIT and MC1R genes, which are responsible for a
      coat colour. The functional annotation of coding regions underlying the breed
      specific CNVs showed that in Norwegian Red, Guernsey, and Simmental significantly
      under- and overrepresented GO terms were related to chemical stimulus involved in
      sensory perception of smell and the KEGG pathways for olfactory transduction. In
      addition, specifically for the Norwegian Red breed, the dopaminergic synapse KEGG
      pathway was significantly enriched within deleted parts of the genome.
      CONCLUSIONS: The CNV landscape in Bos taurus genome revealed by this study was
      highly complex, with inter-breed differences, but also a significant variation
      within breeds. The former, may explain some of the phenotypic differences among
      analysed breeds, and the latter contributes to within-breed variation available
      for selection.

PMID- 29843607
TI  - A potential protective element of myocardial bridge against severe obstructive
      atherosclerosis in the whole coronary system.
AB  - BACKGROUND: Myocardial bridge (MB) is generally described as a congenital benign
      variation. Previous studies have suggested that MB prevents atherosclerotic
      plaques from accumulating within the bridge segment but promotes coronary
      stenosis in the proximal segment adjacent to MB. However, it is still not clear
      whether MB has positive or negative effects on severe obstructive atherosclerosis
      in the whole coronary artery system. METHODS: In this study, 6774 patients with
      symptoms of angina who were clinically diagnosed coronary artery disease (CAD) or
      suspected CAD underwent coronary angiography (CAG) in our center. The presence of
      MB was diagnosed, and a retrospective analysis was performed between MB and
      severe obstructive CAD requiring percutaneous coronary intervention (PCI) or
      coronary artery bypass grafting (CABG) in the whole coronary system. RESULTS:
      Among 6774 patients, 3583 (52.89%) were diagnosed with severe obstructive CAD
      (SOCAD) requiring a treatment of PCI or CABG and enrolled into the SOCAD group;
      and 3191 (47.11%) without SOCAD into the non-SOCAD group. Non-SOCAD and SOCAD
      groups had 512(16.05%) and 66(1.84%) patients with MB, respectively (P < 
      0.0001). The rate of SOCAD requiring PCI or CABG in patients with MB was much
      lower than that in patients without MB (11.42% vs. 56.76%, P <  0.0001). After
      adjusting for sex, age, diabetes mellitus, hypertension, and other risk factors,
      MB still had some positive role in preventing severe obstructive CAD (log-OR = -
      2.134, p-value < 0.0001) through logistic regression. CONCLUSIONS: Our results
      provided a clue that MB might act as a potential protective element against
      severe obstructive atherosclerosis in the whole coronary artery system.

PMID- 29843608
TI  - Transcription profiling of butanol producer Clostridium beijerinckii NRRL B-598
      using RNA-Seq.
AB  - BACKGROUND: Thinning supplies of natural resources increase attention to
      sustainable microbial production of bio-based fuels. The strain Clostridium
      beijerinckii NRRL B-598 is a relatively well-described butanol producer regarding
      its genotype and phenotype under various conditions. However, a link between
      these two levels, lying in the description of the gene regulation mechanisms, is
      missing for this strain, due to the lack of transcriptomic data. RESULTS: In this
      paper, we present a transcription profile of the strain over the whole
      fermentation using an RNA-Seq dataset covering six time-points with the current
      highest dynamic range among solventogenic clostridia. We investigated the
      accuracy of the genome sequence and particular genome elements, including
      pseudogenes and prophages. While some pseudogenes were highly expressed, all
      three identified prophages remained silent. Furthermore, we identified major
      changes in the transcriptional activity of genes using differential expression
      analysis between adjacent time-points. We identified functional groups of these
      significantly regulated genes and together with fermentation and cultivation
      kinetics captured using liquid chromatography and flow cytometry, we identified
      basic changes in the metabolism of the strain during fermentation. Interestingly,
      C. beijerinckii NRRL B-598 demonstrated different behavior in comparison with the
      closely related strain C. beijerinckii NCIMB 8052 in the latter phases of
      cultivation. CONCLUSIONS: We provided a complex analysis of the C. beijerinckii
      NRRL B-598 fermentation profile using several technologies, including RNA-Seq. We
      described the changes in the global metabolism of the strain and confirmed the
      uniqueness of its behavior. The whole experiment demonstrated a good
      reproducibility. Therefore, we will be able to repeat the experiment under
      selected conditions in order to investigate particular metabolic changes and
      signaling pathways suitable for following targeted engineering.

PMID- 29843609
TI  - A multi-scale analysis of bull sperm methylome revealed both species
      peculiarities and conserved tissue-specific features.
AB  - BACKGROUND: Spermatozoa have a remarkable epigenome in line with their degree of
      specialization, their unique nature and different requirements for successful
      fertilization. Accordingly, perturbations in the establishment of DNA methylation
      patterns during male germ cell differentiation have been associated with
      infertility in several species. While bull semen is widely used in artificial
      insemination, the literature describing DNA methylation in bull spermatozoa is
      still scarce. The purpose of this study was therefore to characterize the bull
      sperm methylome relative to both bovine somatic cells and the sperm of other
      mammals through a multiscale analysis. RESULTS: The quantification of DNA
      methylation at CCGG sites using luminometric methylation assay (LUMA) highlighted
      the undermethylation of bull sperm compared to the sperm of rams, stallions,
      mice, goats and men. Total blood cells displayed a similarly high level of
      methylation in bulls and rams, suggesting that undermethylation of the bovine
      genome was specific to sperm. Annotation of CCGG sites in different species
      revealed no striking bias in the distribution of genome features targeted by LUMA
      that could explain undermethylation of bull sperm. To map DNA methylation at a
      genome-wide scale, bull sperm was compared with bovine liver, fibroblasts and
      monocytes using reduced representation bisulfite sequencing (RRBS) and
      immunoprecipitation of methylated DNA followed by microarray hybridization (MeDIP
      chip). These two methods exhibited differences in terms of genome coverage, and
      consistently, two independent sets of sequences differentially methylated in
      sperm and somatic cells were identified for RRBS and MeDIP-chip. Remarkably, in
      the two sets most of the differentially methylated sequences were hypomethylated
      in sperm. In agreement with previous studies in other species, the sequences that
      were specifically hypomethylated in bull sperm targeted processes relevant to the
      germline differentiation program (piRNA metabolism, meiosis, spermatogenesis) and
      sperm functions (cell adhesion, fertilization), as well as satellites and rDNA
      repeats. CONCLUSIONS: These results highlight the undermethylation of bull
      spermatozoa when compared with both bovine somatic cells and the sperm of other
      mammals, and raise questions regarding the dynamics of DNA methylation in bovine
      male germline. Whether sperm undermethylation has potential interactions with
      structural variation in the cattle genome may deserve further attention.

PMID- 29843610
TI  - Bias due to censoring of deaths when calculating extra length of stay for
      patients acquiring a hospital infection.
AB  - BACKGROUND: In many studies the information of patients who are dying in the
      hospital is censored when examining the change in length of hospital stay (cLOS)
      due to hospital-acquired infections (HIs). While appropriate estimators of cLOS
      are available in literature, the existence of the bias due to censoring of deaths
      was neither mentioned nor discussed by the according authors. METHODS: Using
      multi-state models, we systematically evaluate the bias when estimating cLOS in
      such a way. We first evaluate the bias in a mathematically closed form assuming a
      setting with constant hazards. To estimate the cLOS due to HIs non
      parametrically, we relax the assumption of constant hazards and consider a time
      inhomogeneous Markov model. RESULTS: In our analytical evaluation we are able to
      discuss challenging effects of the bias on cLOS. These are in regard to direct
      and indirect differential mortality. Moreover, we can make statements about the
      magnitude and direction of the bias. For real-world relevance, we illustrate the
      bias on a publicly available prospective cohort study on hospital-acquired
      pneumonia in intensive-care. CONCLUSION: Based on our findings, we can conclude
      that censoring the death cases in the hospital and considering only patients
      discharged alive should be avoided when estimating cLOS. Moreover, we found that
      the closed mathematical form can be used to describe the bias for settings with
      constant hazards.

PMID- 29843611
TI  - Comparative analysis of plant MKK gene family reveals novel expansion mechanism
      of the members and sheds new light on functional conservation.
AB  - BACKGROUND: Mitogen-activated protein kinase (MAPK) cascades play critical
      functions in almost every aspect of plant growth and development, which regulates
      many physiological and biochemical processes. As a middle nodal point of the MAPK
      cascades, although evolutionary analysis of MKK from individual plant families
      had some reports, their evolutionary history in entire plants is still not clear.
      RESULTS: To better understand the evolution and function of plant MKKs, we
      performed systematical molecular evolutionary analysis of the MAPKK gene family
      and also surveyed their gene organizations, sequence features and expression
      patterns in different subfamilies. Phylogenetic analysis showed that plant MAPKK
      fall into five different groups (Group A-E). Majority orthology groups seemed to
      be a single or low-copy genes in all plant species analyzed in Group B, C and D,
      whereas group A MKKs undergo several duplication events, generating multiple gene
      copies. Further analysis showed that these duplication events were on account of
      whole genome duplications (WGDs) in plants and the duplicate genes maybe have
      undergone functional divergence. We also found that group E MKKs had mutation
      with one change of serine or theronine might lead to inactivity originated
      through the ancient tandem duplicates in monocots. Moreover, we also identified
      MKK3 integrated NTF2 domain that might have gradually lost the cytoplasmic
      nuclear trafficking activity, which suggests that they may involve with the gene
      function more and more sophistication in the evolutionary process. Moreover,
      expression analyses indicated that plant MKK genes play probable roles in UV-B
      signaling. CONCLUSION: In general, ancient gene and genome duplications are
      significantly conducive to the expansion of the plant MKK gene family. Our study
      reveals two distinct evolutionary patterns for plant MKK proteins and sheds new
      light on the functional evolution of this gene family.

PMID- 29843612
TI  - EqualTDRL: illustrating equivalent tandem duplication random loss rearrangements.
AB  - BACKGROUND: To study the differences between two unichromosomal circular genomes,
      e.g., mitochondrial genomes, under the tandem duplication random loss (TDRL)
      rearrangement it is important to consider the whole set of potential TDRL
      rearrangement events that could have taken place. The reason is that for two
      given circular gene orders there can exist different TDRL rearrangements that
      transform one of the gene orders into the other. Hence, a TDRL event cannot
      always be reconstructed only from the knowledge of the circular gene order before
      a TDRL event and the circular gene order after it. RESULTS: We present the
      program EqualTDRL that computes and illustrates the complete set of TDRLs for
      pairs of circular gene orders that differ by only one TDRL. EqualTDRL considers
      the circularity of the given genomes and certain restrictions on the TDRL
      rearrangements. Examples for the latter are sequences of genes that have to be
      conserved during a TDRL or pairs of genes that frame intergenic regions which
      might represent remnants of duplicated genes. Additionally, EqualTDRL allows to
      determine the set of TDRLs that are minimum with respect to the number of
      duplicated genes. CONCLUSION: EqualTDRL supports scientists to study the complete
      set of TDRLs that possibly could have taken place in the evolution of
      mitochondrial genomes. EqualTDRL is implemented in C++ using the ggplot2 package
      of the open source programming language R and is freely available from
      http://pacosy.informatik.uni-leipzig.de/equaltdrl .

PMID- 29843613
TI  - Identification of genes regulating traits targeted for domestication of field
      cress (Lepidium campestre) as a biennial and perennial oilseed crop.
AB  - BACKGROUND: The changing climate and the desire to use renewable oil sources
      necessitate the development of new oilseed crops. Field cress (Lepidium
      campestre) is a species in the Brassicaceae family that has been targeted for
      domestication not only as an oilseed crop that produces seeds with a desirable
      industrial oil quality but also as a cover/catch crop that provides valuable
      ecosystem services. Lepidium is closely related to Arabidopsis and display
      significant proportions of syntenic regions in their genomes. Arabidopsis genes
      are among the most characterized genes in the plant kingdom and, hence,
      comparative genomics of Lepidium-Arabidopsis would facilitate the identification
      of Lepidium candidate genes regulating various desirable traits. RESULTS:
      Homologues of 30 genes known to regulate vernalization, flowering time, pod
      shattering, oil content and quality in Arabidopsis were identified and partially
      characterized in Lepidium. Alignments of sequences representing field cress and
      two of its closely related perennial relatives: L. heterophyllum and L. hirtum
      revealed 243 polymorphic sites across the partial sequences of the 30 genes, of
      which 95 were within the predicted coding regions and 40 led to a change in amino
      acids of the target proteins. Within field cress, 34 polymorphic sites including
      nine non-synonymous substitutions were identified. The phylogenetic analysis of
      the data revealed that field cress is more closely related to L. heterophyllum
      than to L. hirtum. CONCLUSIONS: There is significant variation within and among
      Lepidium species within partial sequences of the 30 genes known to regulate
      traits targeted in the present study. The variation within these genes are
      potentially useful to speed-up the process of domesticating field cress as future
      oil crop. The phylogenetic relationship between the Lepidium species revealed in
      this study does not only shed some light on Lepidium genome evolution but also
      provides important information to develop efficient schemes for interspecific
      hybridization between different Lepidium species as part of the domestication
      efforts.

PMID- 29843614
TI  - Analysis of randomised trials with long-term follow-up.
AB  - Randomised trials with long-term follow-up can provide estimates of the long-term
      effects of health interventions. However, analysis of long-term outcomes in
      randomised trials may be complicated by problems with the administration of
      treatment such as non-adherence, treatment switching and co-intervention, and
      problems obtaining outcome measurements arising from loss to follow-up and death
      of participants. Methods for dealing with these issues that involve conditioning
      on post-randomisation variables are unsatisfactory because they may involve the
      comparison of non-exchangeable groups and generate estimates that do not have a
      valid causal interpretation. We describe approaches to analysis that potentially
      provide estimates of causal effects when such issues arise. Brief descriptions
      are provided of the use of instrumental variable and propensity score methods in
      trials with imperfect adherence, marginal structural models and g-estimation in
      trials with treatment switching, mixed longitudinal models and multiple
      imputation in trials with loss to follow-up, and a sensitivity analysis that can
      be used when trial follow-up is truncated by death or other events. Clinical
      trialists might consider these methods both at the design and analysis stages of
      randomised trials with long-term follow-up.

PMID- 29843615
TI  - Parallel evolution of storage roots in morning glories (Convolvulaceae).
AB  - BACKGROUND: Storage roots are an ecologically and agriculturally important plant
      trait that have evolved numerous times in angiosperms. Storage roots primarily
      function to store carbohydrates underground as reserves for perennial species. In
      morning glories, storage roots are well characterized in the crop species
      sweetpotato, where starch accumulates in storage roots. This starch-storage
      tissue proliferates, and roots thicken to accommodate the additional tissue. In
      morning glories, storage roots have evolved numerous times. The primary goal of
      this study is to understand whether this was through parallel evolution, where
      species use a common genetic mechanism to achieve storage root formation, or
      through convergent evolution, where storage roots in distantly related species
      are formed using a different set of genes. Pairs of species where one forms
      storage roots and the other does not were sampled from two tribes in the morning
      glory family, the Ipomoeeae and Merremieae. Root anatomy in storage roots and
      fine roots was examined. Furthermore, we sequenced total mRNA from storage roots
      and fine roots in these species and analyzed differential gene expression.
      RESULTS: Anatomical results reveal that storage roots of species in the Ipomoeeae
      tribe, such as sweetpotato, accumulate starch similar to species in the
      Merremieae tribe but differ in vascular tissue organization. In both storage root
      forming species, more genes were found to be upregulated in storage roots
      compared to fine roots. Further, we find that fifty-seven orthologous genes were
      differentially expressed between storage roots and fine roots in both storage
      root forming species. These genes are primarily involved in starch biosynthesis,
      regulation of starch biosynthesis, and transcription factor activity.
      CONCLUSIONS: Taken together, these results demonstrate that storage roots of
      species from both morning glory tribes are anatomically different but utilize a
      common core set of genes in storage root formation. This is consistent with a
      pattern of parallel evolution, thus highlighting the importance of examining
      anatomy together with gene expression to understand the evolutionary origins of
      ecologically and economically important plant traits.

PMID- 29843616
TI  - Long-term clinical outcomes of catheter ablation in patients with atrial
      fibrillation predisposing to tachycardia-bradycardia syndrome: a long pause
      predicts implantation of a permanent pacemaker.
AB  - BACKGROUND: There is a controversy as to whether catheter ablation should be the
      first-line therapy for tachycardia-bradycardia syndrome (TBS) in patients with
      atrial fibrillation (AF). METHODS: We aimed to investigate long-term clinical
      outcomes of catheter ablation in patients with TBS and AF. Among 145 consecutive
      patients who underwent catheter ablation of AF with TBS, 121 patients were
      studied. RESULTS: Among 121 patients, 11 (9.1%) received implantation of a
      permanent pacemaker during a mean 21 months after ablation. Length of pause on
      termination of AF was significantly greater in patients who received pacemaker
      implantation after ablation than those who underwent ablation only (7.9 +/- 3.5
      vs. 5.1 +/- 2.1 s, p < 0.001). Using a multivariate model, a long pause of 6.3 s
      or longer after termination of AF was associated with the requirement to implant
      a permanent pacemaker after ablation (HR 1.332, 95% CI 1.115-1.591, p = 0.002).
      CONCLUSION: This study suggests that, in patients with AF predisposing to TBS,
      long pause on termination of AF predicts the need to implant a permanent
      pacemaker after catheter ablation.

PMID- 29843617
TI  - Genome sequencing and protein domain annotations of Korean Hanwoo cattle identify
      Hanwoo-specific immunity-related and other novel genes.
AB  - BACKGROUND: Identification of genetic mechanisms and idiosyncrasies at the breed
      level can provide valuable information for potential use in evolutionary studies,
      medical applications, and breeding of selective traits. Here, we analyzed genomic
      data collected from 136 Korean Native cattle, known as Hanwoo, using advanced
      statistical methods. RESULTS: Results revealed Hanwoo-specific protein domains
      which were largely characterized by immunoglobulin function. Furthermore, domain
      interactions of novel Hanwoo-specific genes reveal additional links to immunity.
      Novel Hanwoo-specific genes linked to muscle and other functions were identified,
      including protein domains with functions related to energy, fat storage, and
      muscle function that may provide insight into the mechanisms behind Hanwoo
      cattle's uniquely high percentage of intramuscular fat and fat marbling.
      CONCLUSION: The identification of Hanwoo-specific genes linked to immunity are
      potentially useful for future medical research and selective breeding. The
      significant genomic variations identified here can crucially identify genetic
      novelties that are arising from useful adaptations. These results will allow
      future researchers to compare and classify breeds, identify important genetic
      markers, and develop breeding strategies to further improve significant traits.

PMID- 29843618
TI  - Plasma levels of free fatty acid differ in patients with left ventricular
      preserved, mid-range, and reduced ejection fraction.
AB  - BACKGROUND: Free fatty acids (FFAs) predicted the risk of heart failure (HF) and
      were elevated in HF with very low left ventricular ejection fraction (LVEF)
      compared to healthy subjects. The aim of this study was to investigate whether
      total levels of FFA in plasma differed in patients with HF with preserved
      (HFpEF), mid-range (HFmrEF), and reduced ejection fraction (HFrEF) and the
      association with the three categories. METHODS: One hundred thirty-nine patients
      with HFpEF, HFmrEF and HFrEF were investigated in this study. Plasma FFA levels
      were measured using commercially available assay kits, and LVEF was calculated by
      echocardiography with the Simpson biplane method. Dyspnea ranked by New York
      Heart Association (NYHA) was also identified. RESULTS: FFA concentrations were
      higher in HFrEF than in HFmrEF and HFpEF, respectively (689 +/- 321.5 MUmol/L vs.
      537.9 +/- 221.6 MUmol/L, p = 0.036; 689 +/- 321.5 MUmol/L vs. 527.5 +/- 185.5
      MUmol/L, p = 0.008). No significant differences in FFA levels were found between
      HFmrEF and HFpEF (537.9 +/- 221.6 MUmol/L vs. 527.5 +/- 185.5 MUmol/L, p =
      0.619). In addition, we found a negative correlation between FFA levels and LVEF
      (regression coefficient: - 0.229, p = 0.004) and a positive correlation between
      FFAs and NYHA class (regression coefficient: 0.214, p = 0.014) after adjustment
      for clinical characteristic, medical history and therapies. ROC analysis revealed
      that FFAs predicted HFrEF across the three categories (AUC: 0.644, p = 0.005) and
      the optimal cut-off level to predict HFrEF was FFA levels above 575 MUmol/L.
      CONCLUSIONS: FFA levels differed across the three categories, which suggests that
      energy metabolism differs between HFpEF, HFmrEF and HFrEF.

PMID- 29843619
TI  - Patient empowerment and general self-efficacy in patients with coronary heart
      disease: a cross-sectional study.
AB  - BACKGROUND: In managing a life with coronary heart disease and the possibility of
      planning and following a rehabilitation plan, patients' empowerment and self
      efficacy are considered important. However, currently there is limited data on
      levels of empowerment among patients with coronary heart disease, and demographic
      and clinical characteristics associated with patient empowerment are not known.
      The purpose of this study was to assess the level of patient empowerment and
      general self-efficacy in patients six to 12 months after the cardiac event. We
      also aimed to explore the relationship between patient empowerment, general self
      efficacy and other related factors such as quality of life and demographic
      variables. METHODS: A sample of 157 cardiac patients (78% male; age 68 +/- 8.5
      years) was recruited from a Swedish hospital. Patient empowerment was assessed
      using the SWE-CES-10. Additional data was collected on general self-efficacy and
      well-being (EQ5D and Ladder of Life). Demographic and clinical variables were
      collected from medical records and interviews. RESULTS: The mean levels of
      patient empowerment and general self-efficacy on a 0-4 scale were 3.69 (+/-0.54)
      and 3.13 (+/-0.52) respectively, and the relationship between patient empowerment
      and general self-efficacy was weak (r = 0.38). In a simple linear regression,
      patient empowerment and general self-efficacy were significantly correlated with
      marital status, current self-rated health and future well-being. Multiple linear
      regressions on patient empowerment (Model 1) and general self-efficacy (Model 2)
      showed an independent significant association between patient empowerment and
      current self-rated health. General self-efficacy was not independently associated
      with any of the variables. CONCLUSIONS: Patients with a diagnosis of coronary
      heart disease reported high levels of empowerment and general self-efficacy at
      six to 12 months after the event. Clinical and demographic variables were not
      independently associated with empowerment or low general self-efficacy. Patient
      empowerment and general self-efficacy were not mutually interchangeable, and
      therefore both need to be measured when planning for secondary prevention in
      primary health care. TRIAL REGISTRATION: NCT01462799 .

PMID- 29843620
TI  - Paternal characteristics associated with maternal periconceptional use of folic
      acid supplementation.
AB  - BACKGROUND: Maternal predictors of folic acid (FA) supplementation use to reduce
      offspring risk of neural tube defects are well known, while paternal determinants
      for maternal FA use are less known. Such knowledge is important to increase
      women's compliance to recommended periconceptional FA use. METHODS: In a nation
      wide study of 683,785 births registered in the Medical Birth Registry of Norway
      during 1999-2010, the associations between paternal characteristics (age,
      education, occupation, country of origin) and maternal FA use were estimated by
      relative risks (RR) with 95% confidence intervals (CI), using log-binomial
      regression. RESULTS: Maternal FA use before and during pregnancy (adequate FA
      use) was found in 16% of the births. The association between paternal age and
      adequate FA use was inversely U-shaped; adjusted RRs for adequate FA use were
      0.35 (95% CI 0.28-0.43) and 0.72 (95% CI 0.71-0.74) for paternal age < 20 and >=
      40 years, respectively, comparing age 30-34 years. Compulsory education (1-9
      years) among fathers was compared to tertiary education; the RR was 0.69 (95% CI
      0.68-0.71) for adequate FA use. The lower risk of adequate FA use for paternal
      compulsory education was present in all categories of maternal education.
      Occupation classes other than "Higher professionals" were associated with
      decreased risk of adequate FA use, compared with the reference "Lower
      professionals". RR for adequate FA use was 0.58 (95% CI 0.56-0.60) comparing
      fathers from "Low/middle-income countries" with fathers born in Norway.
      CONCLUSION: Adequate FA use in the periconceptional period was lower when fathers
      were younger or older than 30-34 years, had shorter education, had manual or self
      employed occupations, or originated from low/middle-income countries. Partners
      may contribute to increase women's use of periconceptional FA supplementation.

PMID- 29843621
TI  - Summary results of the 2014-2015 DARPA Chikungunya challenge.
AB  - BACKGROUND: Emerging pathogens such as Zika, chikungunya, Ebola, and dengue
      viruses are serious threats to national and global health security. Accurate
      forecasts of emerging epidemics and their severity are critical to minimizing
      subsequent mortality, morbidity, and economic loss. The recent introduction of
      chikungunya and Zika virus to the Americas underscores the need for better
      methods for disease surveillance and forecasting. METHODS: To explore the
      suitability of current approaches to forecasting emerging diseases, the Defense
      Advanced Research Projects Agency (DARPA) launched the 2014-2015 DARPA
      Chikungunya Challenge to forecast the number of cases and spread of chikungunya
      disease in the Americas. Challenge participants (n=38 during final evaluation)
      provided predictions of chikungunya epidemics across the Americas for a six-month
      period, from September 1, 2014 to February 16, 2015, to be evaluated by
      comparison with incidence data reported to the Pan American Health Organization
      (PAHO). This manuscript presents an overview of the challenge and a summary of
      the approaches used by the winners. RESULTS: Participant submissions were
      evaluated by a team of non-competing government subject matter experts based on
      numerical accuracy and methodology. Although this manuscript does not include in
      depth analyses of the results, cursory analyses suggest that simpler models
      appear to outperform more complex approaches that included, for example,
      demographic information and transportation dynamics, due to the reporting biases,
      which can be implicitly captured in statistical models. Mosquito-dynamics,
      population specific information, and dengue-specific information correlated best
      with prediction accuracy. CONCLUSION: We conclude that with careful consideration
      and understanding of the relative advantages and disadvantages of particular
      methods, implementation of an effective prediction system is feasible. However,
      there is a need to improve the quality of the data in order to more accurately
      predict the course of epidemics.

PMID- 29843622
TI  - Do provider birth attitudes influence cesarean delivery rate: a cross-sectional
      study.
AB  - BACKGROUND: When used judiciously, cesarean sections can save lives; but in the
      United States, prior research indicates that cesarean birth rates have risen
      beyond the threshold to help women and infants and become a contributor to
      increased maternal mortality and rising healthcare costs. Healthy People 2020 has
      set the goal for nulliparous, term, singleton, vertex (NTSV) cesarean birth rate
      at no more than 23.9% of births. Currently, cesarean rates vary from 6% to 69% in
      US hospitals, unexplained by clinical or demographic factors. This wide variation
      in cesarean use is also seen among individual providers of intrapartum care.
      Previous research of birth attitudes found providers of intrapartum care hold
      widely differing views, which may be a key underlying factor influencing practice
      variation; however, further study is needed to determine if differences in
      attitudes are associated with differences in clinical outcomes. The purpose of
      this study was to estimate the association between individual provider attitudes
      towards birth and their low-risk primary cesarean rate. METHODS: Four hundred
      providers were drawn from a stratified random sample of all California providers
      of intrapartum care in 2013 and surveyed for their attitudes towards various
      aspects of labor and birth. Providers' NTSV cesarean birth rates were obtained
      for 2013 and 2014. Covariates included gender, years of experience, practice
      location, and primary hospital's NTSV cesarean rate. We used adjusted
      multivariate Poisson regression to compare cesarean rates and linear regression
      to compare attitude scores of providers meeting versus not meeting the Healthy
      People 2020 (HP2020) goal. RESULTS: Two hundred nine total participants
      (obstetricians, family physicians, and midwives) completed surveys, of which 109
      perform cesareans. Providers' NTSV cesarean rate was significantly associated
      with their composite attitudes score [IRR for each one-point increase 1.21 (95%
      CI 1.002-1.45)]. Physicians meeting the HP2020 goal held attitudes which were
      significantly more favorable towards vaginal birth: mean 2.70 (95% CI 2.58-2.83)
      versus 2.91 (95% CI 2.82-3.00), p < 0.01. CONCLUSIONS: Provider attitudinal
      differences are associated with NTSV cesarean rates. Those meeting the HP2020
      goal hold attitudes more favorable towards vaginal birth. These findings may
      present a modifiable target for quality improvement initiatives to decrease low
      risk primary cesareans.

PMID- 29843623
TI  - An assistant workforce to improve screening rates and quality of care for older
      patients in the emergency department: findings of a pre- post, mixed methods
      study.
AB  - BACKGROUND: Older people who present to the Emergency Department (ED) experience
      high rates of prevalent and incident delirium. This study aimed to determine
      whether an assistant workforce in the ED could effectively conduct screening to
      inform assessment and care planning for older people as well as enhance
      supportive care activities for prevention of delirium. METHODS: Using a pre-post
      design, data was collected before and after the introduction of Older Person
      Technical Assistants (OPTAs) in the ED. OPTA activity was recorded during the
      intervention period and a medical record audit undertaken prior to and 9 months
      after implementation. Data were analysed using descriptive statistics for OPTA
      activities. Weighted Kappa scores were calculated comparing concordance in
      screening scores between OPTAs and Aged Services Emergency Team Registered
      Nurses. Changes in the rates of documented screening and supportive care were
      analysed using Chi-square tests. Focus groups were conducted to explore
      clinicians' experiences of the OPTA role. RESULTS: Three thousand five hundred
      fourty two people were seen by OPTAs in 4563 ED Presentations between 1st July
      2011 and 2012. The reproducibility of all screening tools were found to be high
      between the OPTAs and the RNs, with Kappas and ICCs generally all above 0.9. The
      medical record audit showed significant improvement in the rates of documented
      screening, including cognition from 1.5 to 38% (p < 0.001) and review of pain
      from 29 to 75% (p < 0.001). Supportive care such as being given fluids or food
      also improved from 13 to 49% (p < 0.001) and pressure care from 4.8 to 30% (p <
      0.001). This was accomplished with no increase in ED length of stay among this
      age group. Focus group interviews described mixed responses and support for the
      OPTA role. CONCLUSIONS: An assistant workforce in an ED setting was found to
      provide comparable screening results and improve the rates of documented
      screening and supportive care provided to older people with or at risk of
      developing delirium in the ED. There is a need for a shared philosophy to the
      care of older people in the ED. TRIAL REGISTRATION: Australian New Zealand
      Clinical Trials Registration number is ACTRN12617000742370. It was
      retrospectively registered on 22nd May 2017.

PMID- 29843624
TI  - Dyke-Davidoff-Masson syndrome: a case report.
AB  - BACKGROUND: Dyke-Davidoff-Masson syndrome is a rare condition of unknown
      frequency resulting from brain injury due to a multitude of causes; especially in
      early life. Characteristics include cerebral hemiatrophy/hypoplasia,
      contralateral hemiparesis, seizures, and compensatory osseous hypertrophy. CASE
      PRESENTATION: We present a case of a 13-year-old girl who initially presented
      with headaches, followed by episodic complex-partial seizures; which was
      controlled via medication. She also had right sided hemiparesis. Computed
      tomography (CT) showed evidence of left parieto-temporal infarct with cerebral
      atrophy. Complementary magnetic resonance imaging (MRI) did not reveal additional
      information. Workup for young stroke was negative. Upon further evaluation by
      Neuroradiology, features suggesting Dyke-Davidoff-Masson syndrome were confirmed.
      Patient has been under Neurology follow up since. CONCLUSIONS: Due to its rarity,
      Dyke-Davidoff-Masson syndrome may easily be missed by the majority of treating
      clinicians. Knowledge of its features on imaging enables timely and accurate
      diagnosis - allowing appropriate management.

PMID- 29843625
TI  - Clinical and genetic characterization of a Chanarin Dorfman Syndrome patient born
      to diseased parents.
AB  - BACKGROUND: Chanarin Dorfman Syndrome (CDS) is a rare autosomal recessive
      disorder characterized by ichthyosiform non-bullous erythroderma and variable
      involvement of the liver and the neuromuscular system. In CDS patients, the
      accumulation of neutral lipids inside cytoplasmic lipid droplets has been
      demonstrated in different tissues. To date, ninety families with this disease
      have been described worldwide; most of them are from Mediterranean countries.
      CASE PRESENTATION: In this report, we describe a consanguineous Turkish family
      with typical features of CDS. The parents are first cousins and are both
      diseased. At the age of eight, their child presented CDS with non-bullous
      congenital ichthyosiform erythroderma, hepatosteatosis, hepatomegaly and
      ectropion. Electromyographic examination is compatible with myopathy. A five-year
      old cousin of the child is also affected by CDS. She was born to non-affected
      consanguineous parents. Mutation analysis of the ABHD5 gene revealed the
      previously reported mutation, N209X, which is the most frequent in Turkish
      patients. Lipid vacuoles, also known as Jordan's anomaly, are detectable in their
      leucocytes. CONCLUSIONS: To the best of our knowledge, this is the first report
      of a CDS family in which both parents and their child are affected by CDS. To
      date, the child does not present a more severe clinical phenotype compared with
      those of his relatives or other CDS patients of the same age. These findings
      suggest that high levels of triacylglycerol accumulation, that may be supposed to
      be present in high amount inside the ooplasm, did not affect embryo development
      and foetal growth.

PMID- 29843626
TI  - Survival of low birthweight neonates in Uganda: analysis of progress between 1995
      and 2011.
AB  - BACKGROUND: Although low birthweight (LBW) babies represent only 15.5% of global
      births, it is the leading underlying cause of deaths among newborns in countries
      where neonatal mortality rates are high. In Uganda, like many other sub-Saharan
      African countries, the progress of reducing neonatal mortality has been slow and
      the contribution of low birthweight to neonatal deaths over time is unclear. The
      aim of this study is to investigate the association between low birthweight and
      neonatal mortality and to determine the trends of neonatal deaths attributable to
      low birthweight in Uganda between 1995 and 2011. METHODS: Cross-sectional survey
      datasets from Uganda Demographic and Health Surveys between 1995 and 2011 were
      analyzed using binary logistic regression with 95% confidence interval (CI) and
      Kaplan-Meier survival analysis to examine associations and trends of neonatal
      mortalities with respect to LBW. A total of 5973 singleton last-born live births
      with measured birthweights were included in the study. RESULTS: The odds of
      mortality among low birthweight neonates relative to normal birthweight babies
      were; in 1995, 6.2 (95% CI 2.3 -17.0), in 2000-2001, 5.3 (95% CI 1.7 -16.1), in
      2006, 4.3 (95% CI 1.3 - 14.2) and in 2011, 3.8 (95% CI 1.3 - 11.2). The
      proportion of neonatal deaths attributable to LBW in the entire population
      declined by more than half, from 33.6% in 1995 to 15.3% in 2011. Neonatal
      mortality among LBW newborns also declined from 83.8% to 73.7% during the same
      period. CONCLUSION: Low birthweight contributes to a substantial proportion of
      neonatal deaths in Uganda. Although significant progress has been made to reduce
      newborn deaths, about three-quarters of all LBW neonates died in the neonatal
      period by 2011. This implies that the health system has been inadequate in its
      efforts to save LBW babies. A holistic strategy of community level interventions
      such as improved nutrition for pregnant mothers, prevention of teenage
      pregnancies, use of mosquito nets during pregnancy, antenatal care for all,
      adequate skilled care during birth to prevent birth asphyxia among LBW babies,
      and enhanced quality of postnatal care among others could effectively reduce the
      mortality numbers.

PMID- 29843627
TI  - Risk factors for peripartum hysterectomy among women with postpartum haemorrhage:
      analysis of data from the WOMAN trial.
AB  - BACKGROUND: Peripartum hysterectomy can cause significant morbidity and
      mortality. Most studies of peripartum hysterectomy are from high income
      countries. This cohort study examined risk factors for peripartum hysterectomy
      using data from Africa, Asia, Europe and the Americas. METHODS: We used data from
      the World Maternal Antifibrinolytic (WOMAN) trial carried out in 193 hospitals in
      21 countries. Peripartum hysterectomy was defined as hysterectomy within 6 weeks
      of delivery as a complication of postpartum haemorrhage. Univariable and
      multivariable random effects logistic regression models were used to analyse risk
      factors. A hierarchical conceptual framework guided our multivariable analysis.
      RESULTS: Five percent of women had a hysterectomy (1020/20,017). Haemorrhage from
      placenta praevia/accreta carried a higher risk of hysterectomy (17%) than
      surgical trauma/tears (5%) and uterine atony (3%). The adjusted odds ratio (AOR)
      for hysterectomy in women with placenta praevia/accreta was 3.2 (95% CI: 2.7
      3.8), compared to uterine atony. The risk of hysterectomy increased with maternal
      age. Caesarean section was associated with fourfold higher odds of hysterectomy
      than vaginal delivery (AOR 4.3, 95% CI: 3.6-5.0). Mothers in Asia had a higher
      hysterectomy incidence (7%) than mothers in Africa (5%) (AOR: 1.2, 95% CI: 0.9
      1.7). CONCLUSIONS: Placenta praevia/accreta is associated with a higher risk of
      peripartum hysterectomy. Other risk factors for hysterectomy are advanced
      maternal age, caesarean section and giving birth in Asia.

PMID- 29843628
TI  - "Appropriateness of colonoscopy according to EPAGE II in a low resource setting:
      a cross sectional study from Sri Lanka".
AB  - BACKGROUND: Due to finite resources, the clinical decision to subject a patient
      to colonoscopy needs to be based on the evidence, regardless of its availability,
      affordability and safety. This study assessed the appropriateness of
      colonoscopies conducted in selected study settings in Sri Lanka. In the absence
      of local guidelines, audit was based on European Panel on Appropriateness of
      Gastrointestinal Endoscopy II (EPAGE II) criteria. METHODS: This cross-sectional
      study assessed consecutive patients who underwent colonoscopy between June to
      August 2015 at four main hospitals in Sri Lanka. Interviewer administered
      questionnaire and secondary data were collected by trained health staff.
      Indications were assessed according to EPAGE II criteria. RESULTS: Out of 325
      patients, male female proportions were 57.2 and 42.8%. Mean (SD) age was 54.9
      (12.1) years. Colonoscopies were appropriate in 61.2% (95% CI 55.8-66.3),
      uncertain in 28.6% (95% CI 23.9-33.7) and inappropriate in 10.2% (95% CI 7.3
      13.9). Colonoscopy to evaluate abdominal pain has highest percentage of
      inappropriateness of 10.0%. However, 9.5% of these colonoscopies revealed Colo
      Rectal Cancer (CRC), reflecting differences in the profile of local CRC patients.
      Colonoscopies with appropriate or uncertain indications are three times more
      likely to have a relevant finding than inappropriate indications (42.5% vs.
      18.2%; OR 3.32, 95% CI 1.33-8.3; P = 0.008). CONCLUSIONS: Majority of
      colonoscopies are appropriate. However, it cannot be neglected that every one in
      ten patients undergo inappropriate colonoscopy. Proportion of inappropriateness
      was highest for the indication of chronic abdominal pain, of which, 9.5% of
      patients were diagnosed with CRC. This may reflect the different profile of local
      CRC patients in terms of symptom manifestation and other characteristics. In
      conclusion, the authors recommend formulation of national guidelines for
      colonoscopy indications based on current best evidence and local patient profile.
      Use of such prepared local guidelines will improve the efficient use of finite
      resources.

PMID- 29843629
TI  - Antidepressant use during pregnancy and the risk of developing gestational
      hypertension: a retrospective cohort study.
AB  - BACKGROUND: Prior studies reported that exposure to antidepressants during
      pregnancy may be associated with gestational hypertension. The aim of this study
      is to assess the association between the use of antidepressants during pregnancy
      and the risk of developing gestational hypertension. METHODS: A retrospective
      cohort study using the prescription database IADB.nl was conducted among
      nulliparous women with singleton pregnancies between 1994 and 2015 in the
      Netherlands. Logistic regression analysis was used to estimate odds ratios (OR),
      adjusted OR (aOR) and their corresponding 95% confidence intervals (95% CI).
      Gestational hypertension as main outcome measure was defined as at least one
      dispensed record of an antihypertensive drug (methyldopa, nifedipine, labetalol,
      ketanserin, nicardipine) after 20 weeks of gestation until 14 days after
      delivery. Sub-analyses were conducted for class of antidepressant, duration and
      amount of use of antidepressant (<=30, >=30 Defined Daily Doses or DDDs), and
      maternal age. Sensitivity analyses to assess uncertainties were conducted.
      RESULTS: Twenty-eight thousand twenty women were included, of which 539 (1.92%)
      used antidepressants. The risk of gestational hypertension was doubled for women
      using antidepressant (aOR 2.00 95% CI 1.28-3.13). Significant associations were
      also found for the subgroup selective serotonin reuptake inhibitors (SSRIs) (aOR
      2.07 95% CI 1.25-3.44), >=30 DDDs (aOR 2.50 95% CI 1.55-3.99) and maternal age of
      30-34 years (aOR 2.59 95% CI 1.35-4.98). Varying the theoretical gestational age
      showed comparable results. CONCLUSION: Prolonged use of antidepressants during
      the first 20 weeks of gestation appeared to be associated with an increased risk
      of developing gestational hypertension. When balancing the benefits and risks of
      using these drugs during pregnancy, this should be taken into account.

PMID- 29843630
TI  - Unusual presentation of a skull base mass lesion in sarcoidosis mimicking
      malignant neoplasm: a case report.
AB  - BACKGROUND: Sarcoidosis is a multi-organ disease of unknown etiology
      characterised by the presence of epithelioid granulomas, without caseous
      necrosis. Systemic sarcoidosis is rare among children, while neurosarcoidosis in
      children is even rarer whether it is systemic or not. CASE PRESENTATION: We
      described the case of a 12-year-old boy who presented with monocular vision loss
      accompanied by unusual MRI features of an extensive meningeal infiltrating mass
      lesion. The patient underwent surgical resection (biopsy) via a frontotemporal
      craniotomy to establish a definitive diagnosis based on the histopathology, since
      neurosarcoidosis remains a very difficult diagnosis to establish from
      neuroradiogenic imagings. Based on the histopathology of the resected mass
      lesion, neurosarcoidosis was diagnosed. On follow-up after 3 months of steroid
      therapy, the patient displayed a good response on the imaging studies. MRI
      revealed that the preexisting mass lesion had regressed extremely. We also
      conducted a small literature review on imaging studies, manifestations,
      appropriate treatments, etc., in particular neurosarcoidosis including children.
      CONCLUSION: Although extremely rare, neurosarcoidosis, even in children, should
      be considered in the differential diagnosis of skull base mass lesions to avoid
      unnecessary aggressive surgery and delay in treatment, since surgery may have
      little role in the treatment of sarcoidosis.

PMID- 29843631
TI  - Urine IP-10 as a biomarker of therapeutic response in patients with active
      pulmonary tuberculosis.
AB  - BACKGROUND: Prior to clinical trials of new TB drugs or therapeutic vaccines, it
      is necessary to develop monitoring tools to predict treatment outcomes in TB
      patients. Urine interferon gamma inducible protein 10 (IP-10) is a potential
      biomarker of treatment response in chronic hepatitis C virus infection and lung
      diseases, including tuberculosis. In this study, we assessed IP-10 levels in
      urine samples from patients with active TB at diagnosis, during treatment, and at
      completion, and compared these with levels in serum samples collected in parallel
      from matched patients to determine whether urine IP-10 can be used to monitor
      treatment response in patients with active TB. METHODS: IP-10 was measured using
      enzyme-linked immunosorbent assays in urine and serum samples collected
      concomitantly from 23 patients with active TB and 21 healthy adults (44 total
      individuals). The Mann-Whitney U test and Wilcoxon matched-pairs signed rank test
      were used for comparisons among healthy controls and patients at three time
      points, and LOESS regression was used for longitudinal data. RESULTS: The levels
      of IP-10 in urine increased significantly after 2 months of treatment (P =
      0.0163), but decreased by the completion of treatment (P = 0.0035). Serum IP-10
      levels exhibited a similar trend, but did not increase significantly after 2
      months of treatment in patients with active TB. CONCLUSIONS: Unstimulated IP-10
      in urine can be used as a biomarker to monitor treatment response in patients
      with active pulmonary TB.

PMID- 29843632
TI  - Faecal colonization of E. coli and Klebsiella spp. producing extended-spectrum
      beta-lactamases and plasmid-mediated AmpC in Mozambican university students.
AB  - BACKGROUND: In recent years, the world has seen a surge in Enterobacteriaceae
      resistant to broad-spectrum beta-lactam antibiotics due to the production of
      extended-spectrum beta-lactamases (ESBLs) or plasmid-mediated AmpC (pAmpC)
      enzymes. Data on the epidemiology of cephalosporin-resistant Enterobacteriaceae
      in Sub-Saharan Africa are still limited. METHODS: Two hundred seventy-five non
      repetitive stool samples were collected from Mozambican university students of
      both sexes. Samples were cultured on MacConkey agar with and without ceftriaxone
      (1 mg/L) for selection of third-generation cephalosporin-resistant isolates,
      which were subjected to antimicrobial susceptibility testing by disc diffusion,
      characterization of resistance genes by PCR and ERIC-PCR analysis for strain
      clonality. RESULTS: Among the 275 students, 55 (20%) carried a total of 56 E.
      coli (n = 35) and Klebsiella spp. (n = 21) isolates resistant to ceftriaxone and
      phenotypically positive for ESBL- and/or pAmpC-production. Forty-three percent of
      the isolates (24/56) contained only ESBL genes, 11% (6/56) only pAmpC genes, and
      36% (20/56) both ESBL and pAmpC genes. The remaining six isolates were negative
      for the CTX-M/pAmpC genes included in the test panel. E. coli and Klebsiella spp.
      combined demonstrated 70% resistance to tetracycline and co-trimoxazole, 63% to
      ceftazidime and 34% to ciprofloxacin. In total, 89% of ESBL/pAmpC-positive
      isolates were defined as multi-resistant by being resistant to three or more
      antibiotic classes. ERIC-PCR fingerprinting demonstrated low similarity among
      isolates. None of the participants reported recent hospitalization and just 12.5%
      had taken antibiotics 3 months prior to the study. CONCLUSION: This study
      demonstrated 20% colonization with multi-resistant E. coli and Klebsiella spp.
      among Mozambican students with a diversity of ESBL and pAmpC genes. Colonization
      was not related to prior hospitalization or antimicrobial consumption.

PMID- 29843633
TI  - Changes in ovarian cancer survival during the 20 years before the era of targeted
      therapy.
AB  - BACKGROUND: The survival of patients with ovarian cancer has improved because of
      surgery and chemotherapy. This study aimed to estimate the changes in survival
      rates among Korean women with ovarian cancer prior to the introduction of
      targeted therapy for ovarian cancer. METHODS: Data were obtained from the Korea
      Central Cancer Registry regarding patients who were diagnosed with epithelial
      ovarian cancer between 1995 and 2014. The relative survival rates were calculated
      for 5-year periods using the Ederer II method. Cox proportional hazard models
      were created to assess the associations of demographic and clinicopathological
      factors with ovarian cancer survival. RESULTS: During the study period, 22,880
      women were diagnosed with epithelial ovarian cancer. The 5-year relative survival
      rate improved from 57.2% during 1995-1999 to 63.8% during 2010-2014 (P < 0.001).
      Survival outcomes improved between 1995 and 1999 and 2010-2014 for the serous and
      endometrioid carcinoma subtypes (P < 0.001). However, no improvements were
      observed for the mucinous and clear cell carcinoma subtypes (P = 0.189 and P =
      0.293, respectively). Multivariate analysis revealed that younger age, early
      stage, recent diagnosis, primary surgical treatment, and non-serous histological
      subtype were favorable prognostic factors. CONCLUSION: Survival outcomes have
      improved for serous and endometrioid epithelial ovarian cancer in the last 20
      years. However, no improvement was observed for patients with mucinous and clear
      cell carcinoma subtypes.

PMID- 29843634
TI  - GMDS knockdown impairs cell proliferation and survival in human lung
      adenocarcinoma.
AB  - BACKGROUND: Lung adenocarcinoma is the most common type of lung cancer and one of
      the most lethal and prevalent cancers. Aberrant glycosylation was common and
      essential in tumorigenesis, with fucosylation as one of the most common types
      disrupted in cancers. However, it is still unknown whether genes involved in
      fucosylation are important for lung adenocarcinoma development and process.
      METHODS: GMDS is involved in cellular fucosylation. Here we examined GMDS
      expression level at both mRNA and protein level in lung adenocarcinoma. The
      impact of GMDS knockdown on lung adenocarcinoma in vitro and in vivo was
      investigated. Transcriptome changes with GMDS knockdown in lung adenocarcinoma
      cells were also examined to provide insights into related molecular mechanisms.
      RESULTS: GMDS expression is significantly upregulated in lung adenocarcinoma at
      both mRNA and protein levels. Lentivirus-mediated shRNA strategy inhibited GMDS
      expression efficiently in human lung adenocarcinoma cells A549 and H1299, and
      GMDS knockdown impaired cell proliferation, colony formation ability, induced
      cell cycle arrest, and apoptosis in both cell lines. Furthermore, GMDS knockdown
      inhibited tumorigenesis in a xenograft mice model of lung adenocarcinoma.
      Microarray analysis explored the GMDS-mediated molecular network and revealed
      that the CASP8-CDKN1A axis might be critical for lung adenocarcinoma development.
      CONCLUSIONS: These findings suggest that GMDS upregulation is critical for cell
      proliferation and survival in human lung adenocarcinoma and might serve as a
      potential biomarker for lung adenocarcinoma diagnosis and treatment.

PMID- 29843635
TI  - Polypharmacy among HIV positive older adults on anti-retroviral therapy attending
      an urban clinic in Uganda.
AB  - BACKGROUND: Polypharmacy has not been investigated in patients living with HIV in
      developing countries. The aims of this study were to determine the prevalence of
      polypharmacy, the factors associated with polypharmacy and whether polypharmacy
      was associated with adverse effects among older adults on anti-retroviral therapy
      (ART). METHODS: Cross-sectional study in older adults aged 50 and over on ART
      attending an outpatient HIV/AIDS care centre in Uganda. Demographic and clinical
      data collected on number and type of medications plus supplements, possible
      medication related side-effects, comorbidity, frailty, cognitive impairment,
      current CD4 count and viral load. RESULTS: Of 411 participants, 63 (15.3, 95%
      C.I. 11.9, 18.8) had polypharmacy (>= 4 non- HIV medications). In multivariate
      analyses, polypharmacy was associated with one or more hospitalisations in the
      last year (Prevalence Ratio PR = 1.8, 95% C.I. 1.1, 3.1, p = 0.02), prescription
      by an internist (PR = 3.6, 95% C.I. 1.3, 10.5, p = 0.02) and frailty index scores
      of 5 to 6 (PR = 10.6, 95% C.I. 1.4, 78, p = 0.02), and 7 or more (PR = 17.4, 95%
      C.I. 2.4, 126.5, p = 0.005). Polypharmacy was not associated with frequency and
      severity of possible medication related side effects and falls. CONCLUSION:
      Polypharmacy is common among older HIV infected patients in sub-Saharan Africa.
      It's more prevalent among frail people, who have been in hospital in the last
      year and who have been seen by an internist. We found no evidence that
      polypharmacy results in any harm but this is worth exploring further.

PMID- 29843636
TI  - A novel TSC2 missense variant associated with a variable phenotype of tuberous
      sclerosis complex: case report of a Chinese family.
AB  - BACKGROUND: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic
      disorder characterized by the development of hamartomas in multiple organs,
      including the brain, heart, skin, kidney, lung and retina. A diagnosis of TSC is
      established with a recently revised clinical/radiological set of criteria and/or
      a causative mutation in TSC1 or TSC2 gene. CASE PRESENTATION: We report a Chinese
      TSC family with two siblings presenting with multiple hypomelanotic macules,
      cardiac rhabdomyomas and cortical tubers associated with a small subependymal
      nodule. The older child had seizures. A novel heterozygous missense variant in
      the TSC2 gene (c.899G > T, p.G300 V) was identified and shown to be inherited
      from their father as well as paternal grandfather, both of whom presented with
      variable TSC-associated signs and symptoms. CONCLUSION: We identified a novel
      heterozygous TSC2 variant c.899G > T as the causative mutation in a Chinese
      family with TSC, resulting in wide intrafamilial phenotypic variability. Our
      study illustrates the importance of clinical evaluation and genetic testing for
      family members of the patient affected with TSC.

PMID- 29843637
TI  - ARL2 overexpression inhibits glioma proliferation and tumorigenicity via down
      regulating AXL.
AB  - BACKGROUND: Glioma is the most common primary brain tumor in adults with a poor
      prognosis. As a member of ARF subfamily GTPase, ARL2 plays a key role in
      regulating the dynamics of microtubules and mitochondrial functions. Recently,
      ARL2 has been identified as a prognostic and therapeutic target in a variety
      range of malignant tumors. However, the biological functional role of ARL2 in
      glioma still remains unknown. The aim of this study was to explore the expression
      and functional role of ARL2 in glioma. METHODS: In this study, we investigated
      the expression of ARL2 in glioma samples by using RT-PCR, immunohistochemistry
      and western blot. The correlation between ARL2 expression and the outcomes of
      glioma patients was evaluated with survival data from TCGA, CGGA and Rembrandt
      dataset. Lentiviral technique was used for ARL2 overexpression in U87 and U251
      cells. CCK8 assay, colony formation assay, wound healing test, transwell invasion
      assay and in vivo subcutaneous xenograft model were performed to investigated the
      biological functions of ARL2. RESULTS: ARL2 expression was down-regulated in
      glioma, and was inversely associated with poor prognosis in glioma patients.
      Furthermore, exogenous ARL2 overexpression attenuated the growth and colony
      formation abilities of glioma cells, as well as their migration and invasive
      capabilities. Moreover, elevated expression of ARL2 inhibited in vivo
      tumorigenicity of glioma cells. Mechanistically, ARL2 regulated AXL expression,
      which was known as an important functional regulator of proliferation and
      tumorigenicity in glioma cells. CONCLUSION: Our study suggests that ARL2 inhibits
      the proliferation, migration and tumorigenicity of glioma cells by regulating the
      expression of AXL and may conduct as a new prognostic and therapeutic target for
      glioma.

PMID- 29843639
TI  - Lessons learned from the 2009-2010 H1N1 outbreak for the management of the 2013
      silent polio outbreak.
AB  - BACKGROUND: The Israeli Ministry of Health (MoH) encountered two substantial
      outbreaks during the past decade: the H1N1 swine flu outbreak during 2009-2010
      and the silent polio outbreak during 2013. Although both outbreaks share several
      similar characteristics, the functioning of the Israeli MoH was different for
      each case. The aim of this study was to identify factors that contributed to the
      change in the MoH response to the polio outbreak in light of the previous 2009
      2010 H1N1 outbreak. METHODS: We conducted a qualitative research using semi
      structured interviews with 18 Israeli policymakers from the MoH, relevant
      specialists and politicians. Each interview was transcribed and a thematic
      analysis was conducted independently by two researchers. RESULTS: Three main
      themes were found in the interview analysis, which reflect major differences in
      the MoH management policy during the polio outbreak. 1) clinical and
      epidemiological differences between the two disease courses, 2) differences in
      the functioning of the MoH during the outbreaks, 3) differences in the risk
      communication strategies used to reach out to the local health community and the
      general public. Most interviewees felt that the experience of the 2009-2010 H1N1
      outbreak which was perceived as unsuccessful, fueled the MoH engagement and
      proactiveness in the later polio outbreak. CONCLUSION: These findings highlight
      the importance of learning processes within health care organizations during
      outbreaks and may contribute to better performance and higher immunization rates.

PMID- 29843638
TI  - Estrogen receptor alpha dependent regulation of estrogen related receptor beta
      and its role in cell cycle in breast cancer.
AB  - BACKGROUND: Breast cancer (BC) is highly heterogeneous with ~ 60-70% of estrogen
      receptor positive BC patient's response to anti-hormone therapy. Estrogen
      receptors (ERs) play an important role in breast cancer progression and
      treatment. Estrogen related receptors (ERRs) are a group of nuclear receptors
      which belong to orphan nuclear receptors, which have sequence homology with ERs
      and share target genes. Here, we investigated the possible role and
      clinicopathological importance of ERRbeta in breast cancer. METHODS: Estrogen
      related receptor beta (ERRbeta) expression was examined using tissue microarray
      slides (TMA) of Breast Carcinoma patients with adjacent normal by
      immunohistochemistry and in breast cancer cell lines. In order to investigate
      whether ERRbeta is a direct target of ERalpha, we investigated the expression of
      ERRbeta in short hairpin ribonucleic acid knockdown of ERalpha breast cancer
      cells by western blot, qRT-PCR and RT-PCR. We further confirmed the binding of
      ERalpha by electrophoretic mobility shift assay (EMSA), chromatin
      immunoprecipitation (ChIP), Re-ChIP and luciferase assays. Fluorescence-activated
      cell sorting analysis (FACS) was performed to elucidate the role of ERRbeta in
      cell cycle regulation. A Kaplan-Meier Survival analysis of GEO dataset was
      performed to correlate the expression of ERRbeta with survival in breast cancer
      patients. RESULTS: Tissue microarray (TMA) analysis showed that ERRbeta is
      significantly down-regulated in breast carcinoma tissue samples compared to
      adjacent normal. ER + ve breast tumors and cell lines showed a significant
      expression of ERRbeta compared to ER-ve tumors and cell lines. Estrogen treatment
      significantly induced the expression of ERRbeta and it was ERalpha dependent.
      Mechanistic analyses indicate that ERalpha directly targets ERRbeta through
      estrogen response element and ERRbeta also mediates cell cycle regulation through
      p18, p21cip and cyclin D1 in breast cancer cells. Our results also showed the up
      regulation of ERRbeta promoter activity in ectopically co-expressed ERalpha and
      ERRbeta breast cancer cell lines. Fluorescence-activated cell sorting analysis
      (FACS) showed increased G0/G1 phase cell population in ERRbeta overexpressed MCF7
      cells. Furthermore, ERRbeta expression was inversely correlated with overall
      survival in breast cancer. Collectively our results suggest cell cycle and tumor
      suppressor role of ERRbeta in breast cancer cells which provide a potential
      avenue to target ERRbeta signaling pathway in breast cancer. CONCLUSION: Our
      results indicate that ERRbeta is a negative regulator of cell cycle and a
      possible tumor suppressor in breast cancer. ERRbeta could be therapeutic target
      for the treatment of breast cancer.

PMID- 29843640
TI  - Two in One: Epithelioid angiomyolipoma within a classic kidney angiomyolipoma - a
      case report.
AB  - BACKGROUND: Epithelioid angiomyolipoma is defined as potentially malignant
      mesenchymal neoplasm, characterized by proliferating epithelioid cells, whereas
      classic angiomyolipoma, composed of fat, smooth muscle cells and dysmorphic
      vessels, is defined as a potentially benign. The usual or classic angiomyolipoma
      is often found incidentally on imaging studies, relatively easily identified due
      to the presence of fat, in contrast to the epithelioid angiomyolipoma that can
      pose diagnostic challenges. CASE PRESENTATION: We report a 51-year-old female
      patient in which an ultrasonography examination showed a solid mass close to the
      right renal pelvis with hypoechoic and hyperechoic areas. A differential
      diagnosis of atypical sinus lipomatosis, lipoma and a transitional cell carcinoma
      was postulated whereas in a subsequent computed tomography a classic
      angiomyolipoma was postulated. A re-examination by contrast enhanced ultrasound
      revealed a striking perfusion difference of the hypoechoic and hyperechoic areas.
      The hypoechoic area showed homogenous and prolonged enhancement whereas the
      hypoechoic area displayed a marked slower contrast material flooding and a
      relatively rapid wash out. The histological analysis from the biopsy of the
      hyperechoic area showed a classic angiomyolipoma, whereas the sample of the
      hypoechoic central portion revealed an epithelioid angiomyolipoma. A nephrectomy
      was performed because of the malignant potential of the epithelioid variant of
      the angiomyolipoma. CONCLUSIONS: A solid kidney mass with two sharply defined
      parts, one-part compatible with a classical angiomyolipoma and the other being
      suspected of carcinoma, is rare, but also illustrative and instructive. The
      combination of different imaging modalities in the work up of a solid renal mass
      facilitated to discriminate benign from malignant areas.

PMID- 29843641
TI  - Progression into sepsis: an individualized process varying by the interaction of
      comorbidities with the underlying infection.
AB  - BACKGROUND: Development of sepsis is a process with significant variation among
      individuals. The precise elements of this variation need to be defined. This
      study was designed to define the way in which comorbidities contribute to sepsis
      development. METHODS: Three thousand five hundred nine patients with acute
      pyelonephritis (AP), community-acquired pneumonia (CAP), intraabdominal
      infections (IAI) or primary bacteremia (BSI) and at least two signs of the
      systemic inflammatory response syndrome were analyzed. The study primary endpoint
      was to define how comorbidities as expressed in the Charlson's comorbidity index
      (CCI) and the underlying type of infection contribute to development of organ
      dysfunction. The precise comorbidities that mediate sepsis development and risk
      for death among 18 comorbidities recorded were the secondary study endpoints.
      RESULTS: CCI more than 2 had an odds ratio of 5.67 for sepsis progression in
      patients with IAI between significantly higher than AP and BSI. Forward logistic
      regression analysis indicated seven comorbidities that determine transition into
      sepsis in patients with AP, four comorbidities in CAP, six comorbidities in IAI
      and one in BSI. The odds ratio both for progression to sepsis and death with one
      comorbidity or with two and more comorbidities was greater than in the absence of
      comorbidities. CONCLUSIONS: The study described how different kinds of infection
      vary in the degree to which they lead to sepsis. The number of comorbidities that
      enhances the risk of sepsis and death varies depending on the underlying
      infections.

PMID- 29843642
TI  - Gestational weight gain in Chinese women -- results from a retrospective cohort
      in Changsha, China.
AB  - BACKGROUND: The generalizability of the gestational weight gain (GWG) ranges
      recommended by the Institute of Medicine (IOM) to Chinese women is disputed.
      METHODS: In 2016, 16,780 pregnant women who gave birth to live singletons in
      Changsha, China, were enrolled. First, subjects with optimal pregnancy outcomes
      were identified for the GWG percentile distribution description and for
      comparison to the IOM recommendations. Second, all subjects with optimal GWG
      according to the IOM body mass index (BMI) cutoffs and those with optimal GWG
      according to the Asian BMI cutoffs were selected. Pregnancy outcomes were
      compared between those two groups. RESULTS: A total of 13,717 births with optimal
      pregnancy outcomes were selected to describe the GWG distribution. The height and
      central position of the GWG distributions determined by the Asian BMI cutoffs
      differed from those determined by the IOM BMI cutoffs among the overweight and
      obese groups. The recommended IOM GWG ranges were narrower than and shifted to
      the left of the observed distributions. In both BMI classification schemes,
      however, the IOM-recommended ranges were within the middle 70% (Pc 15th-85th) and
      50% (Pc 25th-75th) of the observed distribution. A total of 6438 (38.37%) and
      6110 (36.41%) women gained optimal GWG, according to the IOM and Asian BMI
      classifications, respectively. Compared with those with optimal GWG according to
      IOM BMI cutoffs, women with optimal GWG according to the Asian BMI cutoffs had
      lower risks of both macrosomia (adjusted OR = 0.79, 95%CI: 0.67-0.94) and large
      for-gestational age (adjusted OR = 0.86, 95%CI: 0.76, 0.98). However, no
      significantly different risks of preterm, low birthweight, small-for-gestational
      age, pregnancy-induced hypertension, or gestational diabetes were found between
      them. CONCLUSIONS: The IOM-recommended GWG ranges are within the middle 70% of
      the distributions in Chinese women, and pre-pregnancy weight status should be
      determined by the Asian BMI cut-off points for monitoring and making GWG
      recommendations to Chinese women.

PMID- 29843643
TI  - A pill for the partner via the chlamydia patient? Results from a mixed method
      study among sexual health care providers in the Netherlands.
AB  - BACKGROUND: Chlamydia prevalence in the Netherlands remains high despite targeted
      efforts. Effective Partner Notification (PN) and Partner Treatment (PT) can
      interrupt transmission and prevent re-infections. Patient Initiated Partner
      Treatment (PIPT) may strengthen chlamydia control. This study explores the
      current practice of PN and PT, and benefits of, and barriers and facilitators for
      PIPT among professionals in sexual health care in the Netherlands. METHODS: A
      qualitative study was performed among GPs, GP-assistants (GPAs), physicians and
      nurses working at Sexual Health Clinics (SHC) and key-informants on ethnical
      diversity using topic lists in focus groups (N = 40) and semi-structured
      questionnaires in individual interviews (N = 9). Topics included current
      practices regarding PN and PT, attitude regarding PIPT, and perceived barriers
      and facilitators for PIPT. Interviews were taped, transcribed verbatim, and coded
      using ATLAS.ti. A quantitative online questionnaire on the same topics was sent
      to all physicians and nurses employed at Dutch SHC (complete response rate 26%
      (84/321)). RESULTS: The qualitative study showed that all professionals support
      the need for more attention to PN, and that they saw advantages in PIPT.
      Mentioned barriers included unwilling PN-behaviour, Dutch legislation, several
      medical considerations and inadequate skills of GPs. Also, concerns about limited
      knowledge of cultural sensitivity around PN and PT were raised. Mentioned
      facilitators of PIPT were reliable home based test-kits, phone-contact between
      professionals and notified partners, more consultation time for GPs or GPAs and
      additional training. The online questionnaire showed that SHC employees agreed
      that partners should be treated as soon as possible, but also that they were
      reluctant towards PIPT without counselling and testing. CONCLUSIONS:
      Professionals saw advantages in PIPT, but they also identified barriers hampering
      the potential introduction of PIPT. Improving PN and counselling skills with
      specific focus on cultural sensitivity is needed. PIPT could be considered for
      specific partners. PIPT in combination with home based testing and using e
      healthcare should be further explored and developed.

PMID- 29843644
TI  - Protocol of an ongoing randomized controlled trial of care management for
      comorbid depression and hypertension: the Chinese Older Adult Collaborations in
      Health (COACH) study.
AB  - BACKGROUND: Depression and hypertension are common, costly, and destructive
      conditions among the rapidly aging population of China. The two disorders
      commonly coexist and are poorly recognized and inadequately treated, especially
      in rural areas. METHODS: The Chinese Older Adult Collaborations in Health (COACH)
      Study is a cluster randomized controlled trial (RCT) designed to test the
      hypotheses that the COACH intervention, designed to manage comorbid depression
      and hypertension in older adult, rural Chinese primary care patients, will result
      in better treatment adherence and greater improvement in depressive symptoms and
      blood pressure control, and better quality of life, than enhanced Care-as-Usual
      (eCAU). Based on chronic disease management and collaborative care principles,
      the COACH model integrates the care provided by the older person's primary care
      provider (PCP) with that delivered by an Aging Worker (AW) from the village's
      Aging Association, supervised by a psychiatrist consultant. One hundred sixty
      villages, each of which is served by one PCP, will be randomly selected from two
      counties in Zhejiang Province and assigned to deliver eCAU or the COACH
      intervention. Approximately 2400 older adult residents from the selected villages
      who have both clinically significant depressive symptoms and a diagnosis of
      hypertension will be recruited into the study, randomized by the villages in
      which they live and receive primary care. After giving informed consent, they
      will undergo a baseline research evaluation; receive treatment for 12 months with
      the approach to which their village was assigned; and be re-evaluated at 3, 6, 9,
      and 12 months after entry. Depression and HTN control are the primary outcomes.
      Treatment received, health care utilization, and cost data will be obtained from
      the subjects' electronic medical records (EMR) and used to assess adherence to
      care recommendations and, in a preliminary manner, to establish cost and cost
      effectiveness of the intervention. DISCUSSION: The COACH intervention is designed
      to serve as a model for primary care-based management of common mental disorders
      that occur in tandem with common chronic conditions of later life. It leverages
      existing resources in rural settings, integrates social interventions with the
      medical model, and is consistent with the cultural context of rural life. TRIAL
      REGISTRATION: ClinicalTrials.gov ID: NCT01938963 ; First posted: September 10,
      2013.

PMID- 29843645
TI  - MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho
      AKT.
AB  - BACKGROUND: Aberrant hyperactivation of epithelial proliferation, AKT signaling,
      and association with unopposed estrogen (E2) exposure is the most common
      endometrial cancer dysfunction. In the normal uterus, progesterone (P4) inhibits
      proliferation by coordinating stromal-epithelial cross-talk, which we previously
      showed is mediated by the function of Mitogen-inducible gene 6 (Mig-6). Despite
      their attractive characteristics, non-surgical conservative therapies based on
      progesterone alone have not been universally successful. One barrier to this
      success has been the lack of understanding of the P4 effect on endometrial cells.
      METHOD: To further understand the role of Mig-6 and P4 in controlling uterine
      proliferation, we developed a Sprr2f-cre driven mouse model where Mig-6 is
      specifically ablated only in the epithelial cells of the uterus (Sprr2f cre+ Mig
      6 f/f ). We examined P4 effect and regulation of AKT signaling in the endometrium
      of mutant mice. RESULTS: Sprr2f cre+ Mig-6 f/f mice developed endometrial
      hyperplasia. P4 treatment abated the development of endometrial hyperplasia and
      restored morphological and histological characteristics of the uterus. P4
      treatment reduced cell proliferation which was accompanied by decreased AKT
      signaling and the restoration of stromal PGR and ESR1 expression. Furthermore,
      our in vitro studies revealed an inhibitory effect of MIG-6 on AKT
      phosphorylation as well as MIG-6 and AKT protein interactions. CONCLUSIONS: These
      data suggest that endometrial epithelial cell proliferation is regulated by P4
      mediated Mig-6 inhibition of AKT phosphorylation, uncovering new mechanisms of P4
      action. This information may help guide more effective non-surgical interventions
      in the future.

PMID- 29843646
TI  - Knock-down of LRP/LR promotes apoptosis in early and late stage colorectal
      carcinoma cells via caspase activation.
AB  - BACKGROUND: Cancer remains one of the leading causes of death around the world,
      where incidence and mortality rates are at a constant increase. Tumourigenic
      cells are characteristically seen to over-express the 37 kDa/67 kDa laminin
      receptor (LRP/LR) compared to their normal cell counterparts. This receptor has
      numerous roles in tumourigenesis including metastasis, angiogenic enhancement,
      telomerase activation, cell viability and apoptotic evasion. This study aimed to
      expose the role of LRP/LR on the cellular viability of early (SW-480) and late
      (DLD-1) stage colorectal cancer cells. METHODS: siRNA were used to down-regulate
      the expression of LRP/LR in SW-480 and DLD-1 cells which was assessed using
      western blotting. Subsequently, cell survival was evaluated using the MTT cell
      survival assay and confocal microscopy. Thereafter, Annexin V-FITC/PI staining
      and caspase activity assays were used to investigate the mechanism underlying the
      cell death observed upon LRP/LR knockdown. The data was analysed using Student's
      t-test with a confidence interval of 95%, with p-values of less than 0.05 seen as
      significant. RESULTS: Here we reveal that siRNA-mediated knock-down of LRP led to
      notable decreases in cell viability through increased levels of apoptosis,
      apparent by compromised membrane integrity and significantly high caspase-3
      activity. Down-regulated LRP resulted in a significant increase in caspase-8 and 
      9 activity in both cell lines. CONCLUSIONS: These findings show that the receptor
      is critically implicated in apoptosis and that LRP/LR down-regulation induces
      apoptosis in early and late stage colorectal cancer cells through both apoptotic
      pathways. Thus, this study suggests that siRNA-mediated knock-down of LRP could
      be a possible therapeutic strategy for the treatment of early and late stage
      colorectal carcinoma.

PMID- 29843647
TI  - Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an
      acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations.
AB  - BACKGROUND: Haemophagocytic lymphohistiocytosis (HLH) is considered to be a large
      challenge for clinicians due to the variable overlaps of symptoms with other
      severe diseases and a high rate of mortality. Prompt diagnosis and treatment are
      crucial to avoid a fatal outcome. However, very limited reports have focused on
      HLH during chemotherapy (Ch-HLH) due to a low incidence and insufficient
      knowledge. CASE PRESENTATION: A 22-year-old male was diagnosed with acute
      monocytic leukemia with FLT3-ITD and DNMT3A mutations and pulmonary infection. He
      received IA regimen (Idarubicin, 8 mg/m2/d for 3 days and cytarabine, 100 mg/m2/d
      for 7 days) chemotherapy, anti-infection drugs and blood components transfusions.
      During the stage of bone marrow suppression, he presented with a fever, cytopenia
      (WBC, 0.43 * 109/L; Hb, 73 g/L and PLT, 1 * 109/L), refractory coagulation
      dysfunction (APTT, 104.0 s; PT, 30.5 s and Fbg, 0.87 g/L), splenomegaly (3 cm
      below the costal margin), hyperferritinemia (SF > 3000 MUg/L), increased soluble
      interleukin-II receptors (sIL-2R > 7500 u/mL) and haemophagocytosis in the bone
      marrow and was diagnosed with HLH. After he was treated with methylprednisolone
      at 500 mg/d for 3 days, 120 mg/d for 3 days and 80 mg/d for 3 days, followed by a
      gradually reduced dose combined with powerful anti-infection drugs, his symptoms
      subsided and his abnormal parameters recovered to normal levels. CONCLUSION:
      Patients with HLH in acute leukemia have a high rate of mortality. This case
      report provides helpful clinical experiences relative to the recognition and
      treatment of Ch-HLH for clinicians.

PMID- 29843648
TI  - Comparison of the seventh and eighth editions of the UICC/AJCC staging system for
      nasopharyngeal carcinoma: analysis of 1317 patients treated with intensity
      modulated radiotherapy at two centers.
AB  - BACKGROUND: In the intensity-modulated radiotherapy (IMRT) era, great improvement
      has been made in survival of nasopharyngeal carcinoma (NPC). The 7th edition of
      the International Union against Cancer/American Joint Committee on Cancer
      (UICC/AJCC) staging system seems "outdated " as it mainly based on the study in
      2D/3D era, and thus the 8th edition has made some amendments according to recent
      studies. We aimed to compare and evaluate these two editions of staging system
      for NPC in patients treated with intensity-modulated radiotherapy. METHODS: A
      total of 1317 patients with biopsy-proven, non-metastatic NPC treated with IMRT
      between 2009 and 2014 at two institutions were retrospectively assessed. All
      patients were assessed by magnetic resonance imaging and restaged according to
      the 7th and 8th editions. Prognostic factors for local relapse-free survival
      (LRFS), distant metastasis-free survival (DMFS), disease-free survival (DFS) and
      overall survival (OS) were assessed and compared using the Kaplan-Meier method
      and log-rank test. The Cox proportional hazards model was also used to calculate
      the hazard ratio (HR). RESULTS: In both 7th and 8th edition, insignificant
      difference could be observed between T2 and T3 disease, T2 and T4 disease (all P
      > 0.05) for LRFS, while the difference of LRFS between T3 and T4 disease was
      significant in the previous edition (P = 0.001) but insignificant (P = 0.279)
      after revision. For OS, highly similar survival curve could be seen between T2
      and T3 disease in both edition (all P > 0.1). DMFS and OS were not significantly
      different between N3a and N1-3b categories of the 7th edition (all P > 0.05). In
      contrast, obvious segregation was observed between N3 and the other N categories
      after the revision and combination in the 8th edition (all P < 0.05). DFS and OS
      were not significantly different between stage IVA and IVB of the 7th edition (P
      = 0.057 and P = 0.365, respectively); therefore, combining these stages in the
      8th edition was reasonable. CONCLUSION: The overall stages and N categories of
      the 8th edition of the UICC/AJCC staging system provide better segregation of
      survival outcomes than the 7th edition. The 8th edition is also more clinically
      applicable as it has reduced ambiguity and revised out-of-date definitions.
      However, the T categories need further optimizing as the 8th edition failed to
      solve the problem of similar survival between adjacent T-classification, which
      has been exited since 7th edition.

PMID- 29843649
TI  - Age effect on the prediction of risk of prolonged length hospital stay in older
      patients visiting the emergency department: results from a large prospective
      geriatric cohort study.
AB  - BACKGROUND: With the rapid growth of elderly patients visiting the Emergency
      Department (ED), it is expected that there will be even more hospitalisations
      following ED visits in the future. The aim of this study was to examine the age
      effect on the performance criteria of the 10-item brief geriatric assessment
      (BGA) for the prolonged length of hospital stay (LHS) using artificial neural
      networks (ANNs) analysis. METHODS: Based on an observational prospective cohort
      study, 1117 older patients (i.e., aged >= 65 years) ED users were admitted to
      acute care wards in a University Hospital (France) were recruited. The 10-items
      of BGA were recorded during the ED visit and prior to discharge to acute care
      wards. The top third of LHS (i.e., >= 13 days) defined the prolonged LHS.
      Analysis was successively performed on participants categorized in 4 age groups:
      aged >= 70, >= 75, >= 80 and >= 85 years. Performance criteria of 10-item BGA for
      the prolonged LHS were sensitivity, specificity, positive predictive value [PPV],
      negative predictive value [NPV], likelihood ratios [LR], area under receiver
      operating characteristic curve [AUROC]). The ANNs analysis method was conducted
      using the modified multilayer perceptron (MLP). RESULTS: Values of criteria
      performance were high (sensitivity> 89%, specificity>= 96%, PPV > 87%, NPV > 96%,
      LR+ > 22; LR- <= 0.1 and AUROC> 93), regardless of the age group. CONCLUSIONS:
      Age effect on the performance criteria of the 10-item BGA for the prediction of
      prolonged LHS using MLP was minimal with a good balance between criteria,
      suggesting that this tool may be used as a screening as well as a predictive tool
      for prolonged LHS.

PMID- 29843650
TI  - Horizontal gaze palsy with progressive scoliosis: a case report with magnetic
      resonance tractography and electrophysiological study.
AB  - BACKGROUND: Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare
      autosomal recessive congenital anomaly characterized by horizontal gaze
      limitation and progressive scoliosis. We investigated the underlying pathogenesis
      by incorporating diffusion tensor imaging and an electrophysiological study. CASE
      PRESENTATION: A 55-year-old female patient presented to our clinic due to a
      chronic history of eye movement limitation since childhood. Her eye problem was
      followed by a progressive scoliotic change in her torso during junior high
      school. Neurological examinations revealed remarkable conjugate horizontal but
      not vertical gaze palsy. Her pupils were isocoric, with a prompt response to
      light reflex and convergence. Her vision, including visual acuity and field, were
      normal. No pathological signs of muscle tone, muscle power, deep tendon reflex or
      coordination were revealed. There was no associated family history, and no
      diseases involving other systems were noted. On reviewing her past medical
      history, X-rays revealed scoliotic changes of her thoracic and lumbar spine.
      Brain magnetic resonance imaging showed a midline cleavage at the tegmentum
      (split pons sign) and butterfly configuration of the medulla, consistent with
      HGPPS. Color-coded diffusion tensor imaging in our patient revealed absence of
      decussation of the superior cerebellar peduncle. In tractography, the
      pontocerebellar tracts and fibers within the inferior cerebellar peduncle, deemed
      to be primarily dorsal spinocerebellar and vestibulocerebellar tracts, appeared
      to be agenetic. The tegmentum was compromised secondary to dorsal displacement of
      the corticospinal tracts. Of note, the bilateral corticospinal tracts remained
      uncrossed at the level presumed to be the pyramidal decussation. A somatosensory
      evoked potential study also revealed predominantly ipsilateral cortical sensory
      responses. CONCLUSIONS: Our study confirmed that a compromised tegmentum
      secondary to dorsal displacement of the corticospinal tracts and poorly-developed
      afferent fibers within the pontocerebellar tracts and inferior cerebellar
      peduncle to be the main neuroanatomical anomalies responsible for the clinical
      presentations of HGPPS. In addition, the uncrossed nature of the majority of
      pyramidal and proprioceptive sensory systems was confirmed.

PMID- 29843651
TI  - Clinical and genetic characteristics of pulmonary arterial hypertension in
      Lebanon.
AB  - BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare disease with an
      incidence rate of 2-6 cases per million per year. Our knowledge of the disease in
      the Middle East and North Africa (MENA) region is limited by the small number of
      clinical studies and the complete absence of genetic studies. METHODS: Our aim
      was to shed light on the clinical and genetic characteristics of PAH in Lebanon
      and the region by using exome sequencing on PAH patients referred to the American
      University of Beirut Medical Center (AUBMC). Twenty-one idiopathic, hereditary
      and Congenital Heart Disease (CHD) PAH patients were prospectively recruited,
      their clinical data summarized, and sequencing performed. RESULTS: The mean age
      at diagnosis was 33 years with a female preponderance of 70%. The mean pulmonary
      artery pressure at the time of diagnosis was 55. Genetic testing showed that 5
      out of 19 idiopathic and Congenital Heart Disease PAH patients had Bone
      Morphogenetic Protein Receptor 2 (BMPR2) mutations at 25% prevalence, with 2 of
      these patients exhibiting a novel mutation. It also showed the presence of 1
      BMPR2 mutation with 100% penetrance in a heritable PAH family. In the remaining
      cases, the lack of a complete genotype/phenotype correlation entailed a
      multigenic inheritance; suspected interactions involved previously associated
      genes T-box transcription factor 4 (TBX4), Bone Morphogenic Protein 10 (BMP10)
      and Growth Differentiation Factor 2 (GDF2). CONCLUSIONS: This is the first study
      that looks into the genetic causes of PAH, including known and new BMPR2
      mutations, in the MENA region. It is also the first study to characterize the
      clinical features of the disease in Lebanon.

PMID- 29843652
TI  - Public rental housing and its association with mortality - a retrospective,
      cohort study.
AB  - BACKGROUND: Socioeconomic status (SES) is a well-established determinant of
      health status and home ownership is a commonly used composite indicator of SES.
      Patients in low-income households often stay in public rental housing. The
      association between public rental housing and mortality has not been examined in
      Singapore. METHODS: A retrospective, cohort study was conducted involving all
      patients who utilized the healthcare facilities under SingHealth Regional Health
      (SHRS) Services in Year 2012. Each patient was followed up for 5 years. Patients
      who were non-citizens or residing in a non-SHRS area were excluded from the
      study. RESULTS: A total of 147,004 patients were included in the study, of which
      7252 (4.9%) patients died during the study period. The mean age of patients was
      50.2 +/- 17.2 years old and 7.1% (n = 10,400) of patients stayed in public rental
      housing. Patients who passed away had higher utilization of healthcare resources
      in the past 1 year and a higher proportion stayed in public rental housing (p <
      0.001). They also had higher rates of co-morbidities such as hypertension,
      hyperlipidaemia and diabetes. (p < 0.001) After adjustment for demographic and
      clinical covariates, residence in public rental housing was associated with
      increased risk of all-cause mortality (Adjusted hazard ratio: 1.568, 95% CI:
      1.469-1.673). CONCLUSION: Public rental housing was an independent risk factor
      for all-cause mortality. More studies should be conducted to understand health
      seeking behavior and needs of public rental housing patients, to aid policymakers
      in formulating better plans for improving their health outcomes.

PMID- 29843653
TI  - A case of scleritis associated rheumatoid arthritis accompanying an intraocular
      elevated lesion.
AB  - BACKGROUND: Scleritis and/or uveitis sometimes accompanies patients who suffer
      from rheumatoid arthritis. However, few studies have reported scleritis and/or
      uveitis accompanying a fundus elevated lesion, such as an intraocular tumor. In
      this study, we report a case of rheumatoid uveitis associated with an intraocular
      elevated lesion. CASE PRESENTATION: A 66-year-old female visited another eye
      clinic and was diagnosed as bilateral anterior uveitis, and was prescribed
      steroid eye drops for treatment. She had previously been diagnosed as rheumatoid
      arthritis at the age of 30 years. Due to vitreous opacity that appeared in her
      right eye, we increased the instillation of steroid eye drops and the amount of
      oral prednisolone. Although the inflammation had improved, anterior uveitis
      relapsed, and an intraocular whitish elevated lesion resembling an intraocular
      tumor at the superior nasal retina appeared. We speculated this lesion to be a
      granuloma complicated with rheumatoid arthritis. Thus, we increased the amount of
      prednisolone administration, and the lesion began to shrink and ultimately fully
      disappeared. CONCLUSIONS: We strongly believe that our case's lesion was a
      subretinal granuloma related with rheumatoid arthritis, as it disappeared by
      increased corticosteroid treatment. Our findings show that we should consider
      rheumatoid arthritis in a differential diagnosis of such types of fundus elevated
      lesions.

PMID- 29843654
TI  - Promoting sunscreen use and skin self-examination to improve early detection and
      prevent skin cancer: quasi-experimental trial of an adolescent psycho-educational
      intervention.
AB  - BACKGROUND: Skin cancer rates are increasing. Interventions to increase
      adolescent sunscreen use and skin self-examination (SSE) are required. METHODS:
      Quasi-experimental design; 1 control and 4 intervention group schools in
      Scotland, UK. Participants were 15-16 year old students on the school register.
      The intervention was a theoretically-informed (Common-Sense Model and Health
      Action Process Approach) 50-min presentation, delivered by a skin cancer
      specialist nurse and young adult skin cancer survivor, to students in a
      classroom, supplemented by a home-based assignment. Outcome variables were
      sunscreen use intention, SSE intention/behaviour, planning, illness perceptions
      and skin cancer communication behaviour, measured 2 weeks pre- and 4 weeks post-
      intervention using self-completed pen and paper survey. School attendance records
      were used to record intervention up-take; students self-reported completion of
      the home-based assignment. Pearson's chi-square test, analysis of variance, and
      non-parametric Wilcoxon Signed Ranks Test were used to measure outcomes and
      associations between variables. Focus groups elicited students' (n = 29) views on
      the intervention. Qualitative data were analysed thematically. RESULTS: Five of
      37 invited schools participated. 639 (81%) students in intervention schools
      received the intervention; 33.8% completed the home-based assignment. 627 (69.6%)
      of students on the school register in intervention and control schools completed
      a questionnaire at baseline; data for 455 (72.6%) students were available at
      baseline and follow-up. Focus groups identified four themes - personal
      experiences of skin cancer, distaste for sunscreen, relevance of SSE in
      adolescence, and skin cancer conversations. Statistically significant (p < 0.05)
      changes were observed for sunscreen use, SSE, planning, and talk about skin
      cancer in intervention schools but not the control. Significant associations were
      found between sunscreen use, planning and 2 illness perceptions (identity and
      consequence) and between SSE, planning and 3 illness perceptions (timeline,
      causes, control). CONCLUSIONS: It is feasible to promote sunscreen use and SSE in
      the context of an adolescent school-based psychoeducation intention. Further
      research is required to improve study uptake, intervention adherence and
      effectiveness. TRIAL REGISTRATION: ISRCTN11141528.

PMID- 29843655
TI  - The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social
      and emotional functioning: a systematic narrative review.
AB  - BACKGROUND: The neuropeptide Oxytocin (OXT) plays a central role in birthing,
      mother-infant bonding and a broad range of related social behaviours in mammals.
      More recently, interest has extended to epigenetic programming of genes involved
      in oxytocinergic neurotransmission. This review brings together early findings in
      a rapidly developing field of research, examining relationships between DNA
      methylation (DNAm) of the Oxytocin Receptor Gene (OXTR) and social and emotional
      behaviour in human populations. METHOD: A systematic search across Web of
      Knowledge/Science, Scopus, Medline and EMBASE captured all published studies
      prior to June 2017 examining the association between OXTR DNAm and human social
      and emotional outcomes. Search terms included 'oxytocin gene' or 'oxytocin
      receptor gene' and 'epigenetics' or 'DNA methylation'. Any article with a focus
      on social and emotional functioning was then identified from this set by manual
      review. RESULTS: Nineteen studies met eligibility criteria. There was
      considerable heterogeneity of study populations, tissue samples, instrumentation,
      measurement, and OXTR site foci. Only three studies examined functional
      consequences of OXTR DNAm on gene expression and protein synthesis. Increases in
      OXTR DNAm were associated with callous-unemotional traits in youth, social
      cognitive deficits in Autistic Spectrum Disorder (ASD), rigid thinking in
      anorexia nervosa, affect regulation problems, and problems with facial and
      emotional recognition. In contrast, reductions in DNAm were associated with
      perinatal stress, postnatal depression, social anxiety and autism in children.
      CONCLUSIONS: Consistent with an emerging field of inquiry, there is not yet
      sufficient evidence to draw conclusions about the role of OXTR DNAm in human
      social and emotional behaviour. However, taken together, findings point to
      increased OXTR DNAm in general impairments in social, cognitive and emotional
      functioning, and decreased OXTR DNAm in specific patterns of impairment related
      to mood and anxiety disorders (but not in all). Future progress in this field
      would be enhanced by adequately powered designs, greater phenotypic precision,
      and methodological improvements including longitudinal studies with multiple time
      points to facilitate causal inference.

PMID- 29843656
TI  - Assessment of sexual dysfunction and associated factors among patients with
      schizophrenia in Ethiopia, 2017.
AB  - BACKGROUND: Sexual dysfunction is remarkably prevalent amongst psychiatric
      patients than general population. This might be due to either the nature of the
      illness itself or the unwanted effect of the medication they are taking for the
      illness which limits the capability of forming interpersonal and sexual
      relationships. This issue is rarely raised in developing countries, and the aim
      of this study was to assess magnitude and factors contributing to sexual
      dysfunction among patients with Schizophrenia. METHOD: Hospital based cross
      sectional study was conducted at Amanuel Mental Specialized Hospital from January
      to June 2017. The sample required for this study was determined by using single
      population proportion formula and the final sample size was 423; and systematic
      random sampling was used to select participants. We used Change in Sexual
      Functioning Questionnaire to measure sexual dysfunction. The collected data was
      cleaned, interred in to Epi data and transferred to SPSS version 20 for farther
      analysis. The OR with 95% CI was used to measure association and P-value < 0.05
      was used as statistically significant. RESULT: A total of 422 patients with
      Schizophrenia were involved in the study. The prevalence of General Sexual
      dysfunction was 82.7%; and in male and female patients the prevalence was 84.5
      and 78.6% respectively. Marital status (Unmarried, Divorced and widowed, history
      of relapse and poor quality of life were associated significantly to global
      sexual dysfunction. CONCLUSION: The magnitude of Sexual dysfunction was found to
      be high among patients with schizophrenia and it is associated with different
      factors like unmarried, divorced, widowed, relapse and poor quality of life.
      Treating physicians should be conscious to sexual dysfunction during evaluation
      and treatment of patients with Schizophrenia. Special attention should be given
      to single, divorced, widowed patients and patients with history of relapse to
      improve quality of life of this patients.

PMID- 29843657
TI  - Sexual activity and sexual health among young adults with and without
      mild/moderate intellectual disability.
AB  - BACKGROUND: There is widespread concern about the sexual 'vulnerability' of young
      people with intellectual disabilities, but little evidence relating to sexual
      activity and sexual health. METHOD: This paper describes a secondary analysis of
      the nationally representative longitudinal Next Steps study (formerly the
      Longitudinal Survey of Young People in England), investigating sexual activity
      and sexual health amongst young people with mild/moderate intellectual
      disabilities. This analysis investigated family socio-economic position, young
      person socio-economic position, household composition, area deprivation, peer
      victimisation, friendships, sexual activity, unsafe sex, STIs, pregnancy outcomes
      and parenting. RESULTS: Most young people with mild/moderate intellectual
      disabilities have had sexual intercourse by age 19/20, although young women were
      less likely to have sex prior to 16 than their peers and both men and women with
      intellectual disabilities were more likely to have unsafe sex 50% or more of the
      time than their peers. Women with intellectual disabilities were likely to have
      been pregnant and more likely to be a mother. CONCLUSION: Most young people with
      mild/moderate intellectual disabilities have sex and are more likely to have
      unsafe sex than their peers. Education and health services need to operate on the
      assumption that most young people with mild/moderate intellectual disabilities
      will have sex.

PMID- 29843658
TI  - Exploring psychosocial predictors of STI testing in University students.
AB  - BACKGROUND: To explore university students' Sexually Transmitted Infection (STI)
      testing knowledge, psychosocial and demographic predictors of past STI testing
      behaviour, intentions to have an STI test, and high risk sexual behaviour, to
      inform interventions promoting STI testing in this population. METHODS: A cross
      sectional, quantitative online survey was conducted in March 2016, recruiting
      university students from North East Scotland via an all-student email. The
      anonymous questionnaire assessed student demographics (e.g. sex, ethnicity, age),
      STI testing behaviours, sexual risk behaviours, knowledge and five psychological
      constructs thought to be predictive of STI testing from theory and past research:
      attitudes, perceived susceptibility to STIs, social norms, social fear and self
      efficacy. RESULTS: The sample contained 1294 sexually active students (response
      rate 10%) aged 18-63, mean age = 23.61 (SD 6.39), 888 (69%) were female. Amongst
      participants, knowledge of STIs and testing was relatively high, and students
      held generally favourable attitudes. 52% reported ever having an STI test, 13%
      intended to have one in the next month; 16% reported unprotected sex with more
      than one 'casual' partner in the last six months. Being female, older, a
      postgraduate, longer UK residence, STI knowledge, perceived susceptibility,
      subjective norms, attitudes and self-efficacy all positively predicted past STI
      testing behaviour (p < 0.01). Perceived susceptibility to STIs and social norms
      positively predicted intentions to have an STI test in the next month (p  <
      0.05); perceived susceptibility also predicted past high-risk sexual behaviour (p
      < 0.01). CONCLUSIONS: Several psychosocial predictors of past STI testing, of
      high-risk sexual behaviour and future STI intentions were identified. Health
      promotion STI testing interventions could focus on male students and target
      knowledge, attitude change, and increasing perceived susceptibility to STIs,
      social norms and self-efficacy towards STI-testing.

PMID- 29843659
TI  - Longitudinal study of health, disease and access to care in rural Victoria: the
      Crossroads-II study: methods.
AB  - BACKGROUND: High quality, contemporary data regarding patterns of chronic disease
      is essential for planning by health services, policy makers and local
      governments, but surprisingly scarce, including in rural Australia. This dearth
      of data occurs despite the recognition that rural Australians live with high
      rates of ill health, poor health behaviours and restricted access to health
      services. Crossroads-II is set in the Goulburn Valley, a rural region of
      Victoria, Australia 100-300 km north of metropolitan Melbourne. It is primarily
      an irrigated agricultural area. The aim of the study is to identify changes in
      the prevalence of key chronic health conditions including the extent of
      undiagnosed and undermanaged disease, and association with access to care, over a
      15 year period. METHODS/DESIGN: This study is a 15 year follow up from the 2000
      2003 Crossroads-I study (2376 households participated). Crossroads-II includes a
      similar face to face household survey of 3600 randomly selected households across
      four towns of sizes 6300 to 49,800 (50% sampled in the larger town with the
      remainder sampled equally from the three smaller towns). Self-reported health,
      health behaviour and health service usage information is verified and
      supplemented in a nested sub-study of 900 randomly selected adult participants in
      'clinics' involving a range of additional questionnaires and biophysical
      measurements. The study is expected to run from October 2016 to December 2018.
      DISCUSSION: Besides providing epidemiological and health service utilisation
      information relating to different diseases and their risk factors in towns of
      different sizes, the results will be used to develop a composite measure of
      health service access. The importance of access to health services will be
      investigated by assessing the correlation of this measure with rates of
      undiagnosed and undermanaged disease at the mesh block level. Results will be
      shared with partner organisations to inform service planning and interventions to
      improve health outcomes for local people.

PMID- 29843660
TI  - Gene expression profiling of 1200 pancreatic ductal adenocarcinoma reveals novel
      subtypes.
AB  - BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause
      of cancer related death in the world with a five-year survival rate of less than
      5%. Not all PDAC are the same, because there exist intra-tumoral heterogeneity
      between PDAC, which poses a great challenge to personalized treatments for PDAC.
      METHODS: To dissect the molecular heterogeneity of PDAC, we performed a
      retrospective meta-analysis on whole transcriptome data from more than 1200 PDAC
      patients. Subtypes were identified based on non-negative matrix factorization
      (NMF) biclustering method. We used the gene set enrichment analysis (GSEA) and
      survival analysis to conduct the molecular and clinical characterization of the
      identified subtypes, respectively. RESULTS: Six molecular and clinical distinct
      subtypes of PDAC: L1-L6, are identified and grouped into tumor-specific (L1, L2
      and L6) and stroma-specific subtypes (L3, L4 and L5). For tumor-specific
      subtypes, L1 (~ 22%) has enriched carbohydrate metabolism-related gene sets and
      has intermediate survival. L2 (~ 22%) has the worst clinical outcomes, and is
      enriched for cell proliferation-related gene sets. About 23% patients can be
      classified into L6, which leads to intermediate survival and is enriched for
      lipid and protein metabolism-related gene sets. Stroma-specific subtypes may
      contain high non-epithelial contents such as collagen, immune and islet cells,
      respectively. For instance, L3 (~ 12%) has poor survival and is enriched for
      collagen-associated gene sets. L4 (~ 14%) is enriched for various immune-related
      gene sets and has relatively good survival. And L5 (~ 7%) has good clinical
      outcomes and is enriched for neurotransmitter and insulin secretion related gene
      sets. In the meantime, we identified 160 subtype-specific markers and built a
      deep learning-based classifier for PDAC. We also applied our classification
      system on validation datasets and observed much similar molecular and clinical
      characteristics between subtypes. CONCLUSIONS: Our study is the largest cohort of
      PDAC gene expression profiles investigated so far, which greatly increased the
      statistical power and provided more robust results. We identified six molecular
      and clinical distinct subtypes to describe a more complete picture of the PDAC
      heterogeneity. The 160 subtype-specific markers and a deep learning based
      classification system may be used to better stratify PDAC patients for
      personalized treatments.

PMID- 29843661
TI  - High prevalence rates for multiple psychiatric conditions among inmates at French
      Guiana's correctional facility: diagnostic and demographic factors associated
      with violent offending and previous incarceration.
AB  - BACKGROUND: French Guiana has the highest incarceration rate among French
      territories, it is higher than that of Brazil, Colombia or Venezuela. It is well
      known that mental health problems are over-represented in correctional
      facilities. Our objectives were to describe the prevalence of various psychiatric
      conditions and to study factors associated with violence and repeated offenses
      among arriving detainees at the sole correctional facility of French Guiana.
      METHODS: The study was cross-sectional. All consenting new adult prisoners
      incarcerated between 18/09/2013 and 31/12/2014 at the penitentiary centre of
      French Guiana were included. The Mini International Neuropsychiatric Interview
      (MINI) was used to screen for psychiatric diagnoses. In addition sociodemographic
      data was collected. RESULTS: Overall 647 men and 60 women were included. The
      participation rate was 90%.Overall 72% of patients had at least one psychiatric
      diagnosis (Fig. 2). Twenty percent had three or more diagnoses. Violent index
      offences were not more frequent among those with a psychiatric diagnosis (crude
      odds ratio 1.3 (95%CI = 0.9-2), P = 0.11. Multivariate analysis showed that after
      adjusting for sex and age, psychosis, suicidality and post-traumatic stress
      disorder were independently associated with violent offences. Generalized anxiety
      disorder was less likely to be associated with incarceration for violent
      offences. Having a history of a previous incarceration was significantly
      associated with a psychiatric condition in general (any diagnosis) OR = 3 (95%CI
      = 2-4.3), P < 0.0001. Calculations of the population attributable risks showed
      that in the sample 31.4% of repeat incarcerations were attributable to antisocial
      personality disorder, 28.3% to substance addiction, 17.3% to alcohol addiction,
      8.7% to depression and 7% to psychosis. CONCLUSIONS: The very high prevalence of
      psychiatric disorders observed in our sample, and the relative lack of
      psychiatric facilities, suggest that part of the problem of very high
      incarceration rate may be explained by transinstitutionalization. Improving
      psychiatric care in prison and coordination with psychiatric care in the
      community after release is likely to be important.

PMID- 29843662
TI  - Associations between loneliness and perceived social support and outcomes of
      mental health problems: a systematic review.
AB  - BACKGROUND: The adverse effects of loneliness and of poor perceived social
      support on physical health and mortality are established, but no systematic
      synthesis is available of their relationship with the outcomes of mental health
      problems over time. In this systematic review, we aim to examine the evidence on
      whether loneliness and closely related concepts predict poor outcomes among
      adults with mental health problems. METHODS: We searched six databases and
      reference lists for longitudinal quantitative studies that examined the
      relationship between baseline measures of loneliness and poor perceived social
      support and outcomes at follow up. Thirty-four eligible papers were retrieved.
      Due to heterogeneity among included studies in clinical populations, predictor
      measures and outcomes, a narrative synthesis was conducted. RESULTS: We found
      substantial evidence from prospective studies that people with depression who
      perceive their social support as poorer have worse outcomes in terms of symptoms,
      recovery and social functioning. Loneliness has been investigated much less than
      perceived social support, but there is some evidence that greater loneliness
      predicts poorer depression outcome. There is also some preliminary evidence of
      associations between perceived social support and outcomes in schizophrenia,
      bipolar disorder and anxiety disorders. CONCLUSIONS: Loneliness and quality of
      social support in depression are potential targets for development and testing of
      interventions, while for other conditions further evidence is needed regarding
      relationships with outcomes.

PMID- 29843663
TI  - Anti-vascular endothelial growth factor for neovascular age-related macular
      degeneration: a meta-analysis of randomized controlled trials.
AB  - BACKGROUND: To evaluate the relative efficacy and safety of anti-vascular
      endothelial growth factor (anti-VEGF) agents for the treatment of neovascular age
      related macular degeneration (AMD). METHODS: Systematic literature review
      identifying RCTs comparing anti-VEGF agents to another treatment published before
      June 2016. Efficacy assessed by mean change in best corrected visual acuity
      (BCVA) and central macular thickness (CMT) from baseline at up to 2 years
      followup. Safety assessed by proportions of patients with death,
      arteriothrombotic and venous thrombotic events, and at least one serious systemic
      adverse event at up to 2 years of followup. RESULTS: Fifteen RCTs selected for
      meta-analysis (8320 patients). Two trials compared pegaptanib, and three trials
      compared ranibizumab versus control. Eight trials compared bevacizumab with
      ranibizumab. Two trials compared aflibercept with ranibizumab. There were no
      significant differences between bevacizumab and ranibizumab for BCVA at 1 or 2
      years (weighted mean difference = - 0.57, 95% CI - 1.55 to 0.41, P = 0.25 and
      weighted mean difference = - 0.76, 95% CI - 2.25 to 0.73, P = 0.32,
      respectively). Ranibizumab was more effective in reducing CMT at 1 year (weighted
      mean difference = 4.49, 95% CI 1.13 to 7.84, P = 0.009). Risk ratios comparing
      rates of serious systemic adverse events at 1 and 2 years were slightly out of
      favour for bevacizumab. Aflibercept compared with ranibizumab demonstrated
      similar mean change in BCVA, reduction in CMT, and safety at 1 year. CONCLUSIONS:
      Bevacizumab and ranibizumab had equivalent efficacy for BCVA, while ranibizumab
      had greater reduction in CMT and less rate of serious systemic adverse events.
      Aflibercept and ranibizumab had comparable efficacy for BCVA and CMT. This
      provides information to balance comparable effects on vision and risk of adverse
      events between anti-VEGF agents.

PMID- 29843664
TI  - Predictors of latent tuberculosis infection treatment completion in the US
      private sector: an analysis of administrative claims data.
AB  - BACKGROUND: Factors that affect latent tuberculosis infection (LTBI) treatment
      completion in the US have not been well studied beyond public health settings.
      This gap was highlighted by recent health insurance-related regulatory changes
      that are likely to increase LTBI treatment by private sector healthcare
      providers. We analyzed LTBI treatment completion in the private healthcare
      setting to facilitate planning around this important opportunity for tuberculosis
      (TB) control in the US. METHODS: We analyzed a national sample of commercial
      insurance medical and pharmacy claims data for people ages 0 to 64 years who
      initiated daily dose isoniazid treatment between July 2011 and March 2014 and who
      had complete data. All individuals resided in the US. Factors associated with
      treatment completion were examined using multivariable generalized ordered logit
      models and bivariate Kruskal-Wallis tests or Spearman correlations. RESULTS: We
      identified 1072 individuals with complete data who initiated isoniazid LTBI
      treatment. Treatment completion was significantly associated with less
      restrictive health insurance, age < 15 years, patient location, use of interferon
      gamma release assays, non-poverty, HIV diagnosis, immunosuppressive drug therapy,
      and higher cumulative counts of clinical risk factors. CONCLUSIONS: Private
      sector healthcare claims data provide insights into LTBI treatment completion
      patterns and patient/provider behaviors. Such information is critical to
      understanding the opportunities and limitations of private healthcare in the US
      to support treatment completion as this sector's role in protecting against and
      eliminating TB grows.

PMID- 29843665
TI  - Network meta-analysis: users' guide for pediatricians.
AB  - BACKGROUND: Network meta-analysis (NMA) is a powerful analytic tool that allows
      simultaneous comparison between several management/treatment alternatives even
      when direct comparisons of the alternatives (such as the case in which treatments
      are compared against placebo and have not been compared against each other) are
      unavailable. Though there are still a limited number of pediatric NMAs published,
      the rapid increase in NMAs in other areas suggests pediatricians will soon be
      frequently facing this new form of evidence summary. DISCUSSION: Evaluating the
      NMA evidence requires serial judgments on the creditability of the process of NMA
      conduct, and evidence quality assessment. First clinicians need to evaluate the
      basic standards applicable to any meta-analysis (e.g. comprehensive search,
      duplicate assessment of eligibility, risk of bias, and data abstraction). Then
      evaluate specific issues related to NMA including precision, transitivity,
      coherence, and rankings. CONCLUSIONS: In this article we discuss how clinicians
      can evaluate the credibility of NMA methods, and how they can make judgments
      regarding the quality (certainty) of the evidence. We illustrate the concepts
      using recent pediatric NMA publications.

PMID- 29843666
TI  - The level of lipopolysaccharide-binding protein is elevated in adult patients
      with obstructive sleep apnea.
AB  - BACKGROUND: lipopolysaccharide-binding protein (LBP) has been to be a surrogate
      marker of inflammation in OSA. This study aimed to test the hypothesis that the
      concentration of LBP is elevated in adult patients with obstructive sleep apnea
      (OSA). METHODS: A total of 90 patients were enrolled into the study, 50 subjects
      were divided into OSA groups and 40 in healthy control according to PSG
      examination. Subsequently, patients with apnea-hypopnea index (AHI) ? 5, were
      divided into different subgroups according to blood pressure, gender, body mass
      index (BMI) and AHI. Venous blood samples were collected for detection after
      polysomnography. The serum levels of LBP and proinflammatory cytokines
      (interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha) were tested by
      ELISA. RESULTS: The present study demonstrated that the serum levels of both LBP
      and proinflammatory cytokines were elevated in OSA patients. A stratified
      analysis conducted to analyze differences among subgroups indicated that OSA
      patients with a higher AHI or BMI had an increased level of LBP and
      proinflammatory cytokines (all p < 0.05). Furthermore, a significant correlations
      were observed between LBP and inflammation and AHI. Multivariate regression
      analysis also demonstrated that AHI, LSaO2 and BMI had impact on the
      concentration of LBP. CONCLUSION: The research showed that the serum level of LBP
      and proinflammatory cytokines were elevated in adult patients with OSA, and an
      association with severity of disease and BMI were established. Furthermore, sleep
      apnea and BMI had effect on the concentration of LBP.

PMID- 29843667
TI  - Access to HIV care and treatment for migrants between Lesotho and South Africa: a
      mixed methods study.
AB  - BACKGROUND: HIV treatment and care for migrants is affected by their mobility and
      interaction with HIV treatment programs and health care systems in different
      countries. To assess healthcare needs, preferences and accessibility barriers of
      HIV-infected migrant populations in high HIV burden, borderland districts of
      Lesotho. METHODS: We selected 15 health facilities accessed by high patient
      volumes in three districts of Maseru, Leribe and Mafeteng. We used a mixed
      methods approach by administering a survey questionnaire to consenting HIV
      infected individuals on anti-retroviral therapy (ART) and utilizing a purposive
      sampling procedure to recruit health care providers for qualitative in-depth
      interviews across facilities. RESULTS: Out of 524 HIV-infected migrants enrolled
      in the study, 315 (60.1%) were from urban and 209 (39.9%) from rural sites. Of
      these, 344 (65.6%) were women, 375 (71.6%) were aged between 26 and 45 years and
      240 (45.8%) were domestic workers. A total of 486 (92.7%) preferred to collect
      their medications primarily in Lesotho compared to South Africa. From 506 who
      responded to the question on preferred dispensing intervals, 63.1% (n = 319)
      preferred 5-6 month ARV refills, 30.2% (n = 153) chose 3-4 month refills and only
      6.7% (n = 34) opted for the standard-of-care 1-2 month refills. A total of 126
      (24.4%) defaulted on their treatment and the primary reason for defaulting was
      failure to get to Lesotho to collect medication (59.5%, 75/126). Treatment
      default rates were higher in urban than rural areas (28.3% versus 18.4%, p =
      0.011). Service providers indicated a lack of transfer letters as the major
      drawback in facilitating care and treatment for migrants, followed by
      discrimination based on nationality or language. Service providers indicated that
      most patients preferred all treatment services to be rendered in Lesotho, as they
      perceive the treatment provided in South Africa to be different often less strong
      or with more serious side effects. CONCLUSION: Existing healthcare systems in
      both South Africa and Lesotho experience challenges in providing proper care and
      treatment for HIV infected migrants. A need for a differentiated model of ART
      delivery to HIV infected migrants that allows for multi-month scripting and
      dispensing is warranted.

PMID- 29843668
TI  - Correlation of subfoveal choroidal thickness with axial length, refractive error,
      and age in adult highly myopic eyes.
AB  - BACKGROUND: Subfoveal choroidal thickness (SFCT) in highly myopic eyes was found
      to be correlated with increasing age, refractive error (spherical equivalent),
      and axial length. Which factor is the most significant predictor of SFCT remains
      controversial. METHODS: A hospital-based cohort of highly myopic eyes (with
      spherical equivalent equal to or over 6.00 diopter) were retrospectively
      screened. Data from only right eye in those bilateral high myopia, and unilateral
      high myopia in any eye, were used for analysis. Correlations among the four
      biometric factors were analyzed. Linear correlation was performed to analyze the
      predictors of SFCT. RESULTS: A cohort of 312 eyes from 312 adults (98 men) was
      enrolled. Statistical analysis showed that axial length (R = - 0.592), spherical
      equivalent (R = - 0.471), and age (R = - 0.296) were significantly correlated
      with SFCT (P < 0.001). No significant correlation was found between age and axial
      length, or age and spherical equivalent. Partial correlation with controlled age
      confirmed that axial length (R = - 0.628) was a more significant predictor of
      SFCT than spherical equivalent (R = - 0.507). CONCLUSIONS: SFCT was inversely
      correlated with increasing age, spherical equivalent and axial length, with axial
      length as the most significant predictor of SFCT, in adult highly myopic eyes.

PMID- 29843669
TI  - Expression of MyoD, insulin like growth factor binding protein, thioredoxin and
      p27 in secondarily overacting inferior oblique muscles with superior oblique
      palsy.
AB  - BACKGOUND: To identify and compare specific protein levels between overacting
      inferior oblique (IO) muscles in superior oblique (SO) palsy patients and normal
      IO muscles. METHODS: We obtained 20 IO muscle samples from SO palsy patients with
      IO overaction >= + 3 who underwent IO myectomies (IOOA group), and 20 IO samples
      from brain death donors whose IO had functioned normally, according to their
      ophthalmological chart review (control group). We used MyoD for identifying
      satellite cell activation, insulin-like growth factor binding protein 5 (IGFBP5)
      for IGF effects, thioredoxin for oxidative stress, and p27 for satellite cell
      activation or oxidative stress in both groups. Using immunohistochemistry and
      Western blot, we compared expression levels of the four proteins (MyoD, IGFBP5,
      thioredoxin, and p27). RESULTS: Levels of thioredoxin and p27 were decreased
      significantly in the IOOA group. MyoD and IGFBP5 levels showed no significant
      difference between the groups. CONCLUSIONS: Based on these findings, the
      overacting IOs of patients with SO palsy had been under oxidative stress status
      versus normal IOs. Pathologically overacting extraocular muscles may have an
      increased risk of oxidative stress compared with normal extraocular muscles.

PMID- 29843670
TI  - Study protocol: intervention in maternal perception of preschoolers' weight among
      Mexican and Mexican-American mothers.
AB  - BACKGROUND: Childhood obesity is a public health issue negatively affecting
      children's physical and psychosocial health. Mothers are children's primary
      caregivers, thus key players in childhood obesity prevention. Studies have
      indicated that mothers underestimate their children's weight. If mothers are
      unaware of their children's weight problem, they are less likely to participate
      in activities preventing and treating excess weight. The "Healthy Change"
      intervention is designed to change maternal perception of child's weight (MPCW)
      through peer-led group health education in childcare settings. METHODS/DESIGN:
      The "Healthy Change" is a multicenter two-arm randomized trial in four centers.
      Three centers are in Mexican States (Nuevo Leon, Tamaulipas, and Zacatecas). The
      fourth center is in San Antonio, Texas, USA. A total of 360 mother-child pairs
      (90 pairs per center) are to be randomly and evenly allocated to either the
      intervention or the control group. Intervention group will receive four-session
      group obesity prevention education. Control group will receive a four-session
      personal and food hygiene education. The education is delivered by trained peer
      mother promotoras. Data will be collected using questionnaires and focus groups.
      The primary outcome is a change in proportion of mothers with accurate MPCW.
      Secondary outcomes include change in maternal feeding styles and practices,
      maternal self-efficacy and actions for managing child excessive weight gain.
      McNemar's Test will be used to test the primary outcome. The GLM Univariate
      procedure will be used to determine intervention effects on secondary outcomes.
      The models will include the secondary outcome measures as the dependent
      variables, treatment condition (intervention/control) as the fixed factor, and
      confounding factors (e.g., mother's education, children's gender and age) as
      covariates. Sub-analyses will be performed to compare intervention effects on
      primary and secondary outcomes between the samples from Mexico and Texas, USA.
      Qualitative data will be analyzed through analysis of inductive content. A
      combined coding model will be developed and used to code transcripts using the
      NVivo software. DISCUSSION: Healthy Change intervention could help change MPCW,
      an initial step for obesity prevention among preschoolers. This study presents a
      first of its kind intervention available in Spanish and English targeting Mexican
      and Mexican-American mothers in Mexico and USA. TRIAL REGISTRATION:
      ISRCTN12281648.

PMID- 29843671
TI  - Insomnia and depressive symptoms in relation to unhealthy eating behaviors in
      bariatric surgery candidates.
AB  - BACKGROUND: Alongside obesity, insomnia and depression are common public health
      problems. Sleep problems are currently believed to be associated with excessive
      food intake and metabolic disturbances. Therefore, we aimed to explore a
      relationship between insomnia, depressive symptoms and eating habits as well as
      metabolic parameters in bariatric surgery candidates. METHODS: A total of 361
      unrelated obese subjects were included in this study. Severity of sleep problems
      was measured with Athens Insomnia Scale (AIS) and the severity of depressive
      symptoms was assessed with the Beck Depression Inventory (BDI-II). Obstructive
      sleep apnea (OSA) was assessed by the Apnea Hypopnoea Index (AHI). Information
      was obtained about demographics, eating habits and lifestyle. Blood samples were
      collected to measure concentration of lipids (cholesterol, triglyceride, HDL
      cholesterol, LDL-cholesterol), and glucose. RESULTS: The median (interquartile
      range) score for AIS in the study participants was 5 (3-8) with a range of 0-24
      and 47% (171) participants scored >=6 (met criteria for diagnosis of insomnia).
      Statistically significant correlations were found between the AIS scores and
      serum triglycerides and glucose concentrations, and BDI-II total scores. The
      highest scores on AIS and BDI-II were found in participants with high frequency
      of snack food consumption, in physically inactive individuals as well as in those
      who self-reported eating at night or who declared more than 3 intense emotions
      associated with a desire-to-eat. Adjusted multivariate logistic regression
      analysis revealed that clinical insomnia was most strongly associated with daily
      consumption of snack foods, with the odds ratio of 3.26 (95% CI: 1.74-6.11),
      while depressive symptoms were strongly associated with both eating in response
      to >=3 specific emotions with OR = 2.93 (95% CI: 1.26-6.78) as well as with daily
      consumption of snack foods with OR = 2.87 (95% CI: 1.16-5.14). CONCLUSIONS: The
      results indicate that insomnia and depression in obese individuals are associated
      with eating habits, and suggest that in some patients these associations appears
      as major factors affecting obesity development.

PMID- 29843672
TI  - Effects of controlled abnormal joint movement on the molecular biological
      response in intra-articular tissues during the acute phase of anterior cruciate
      ligament injury in a rat model.
AB  - BACKGROUND: The anterior cruciate ligament (ACL) is responsible for braking
      forward movement of the tibia relative to the femur and for tibial rotation.
      After ACL injury, this braking performance deteriorates, inducing abnormal joint
      movement. The purpose of this study was to clarify the effects of controlled
      abnormal joint movement on the molecular biological response in intra-articular
      tissues during the acute phase of ACL injury. METHODS: Eighty-four mature Wistar
      male rats were randomly assigned to a controlled abnormal movement (CAM) group,
      an ACL-transection (ACL-T) group, a sham-operated group, or an intact group. The
      ACL was completely transected at its midportion in the ACL-T and CAM groups, and
      a nylon suture was used to control abnormal tibial translation in the CAM group.
      The sham-operated group underwent skin and joint capsule incisions and tibial
      drilling without ACL transection. Animals were not restricted activity until
      sacrifice 1, 3, or 5 days after surgery for histological and gene expression
      assessments. Acute-phase inflammation requires an important balance between
      degenerative and biosynthetic processes and is controlled by the activities of
      matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases
      (TIMPs). Both types of gene were analyzed in this study. RESULTS: The ACL-T and
      CAM groups exhibited cleavage of the ACL at all time points. However, for the CAM
      group, the gap in the ligament stump was extremely small, and fibroblast
      proliferation was observed around the stump. Relative to the ACL-T group, the CAM
      group demonstrated significantly lower expression of MMP-13 mRNA and a lower MMP
      13/TIMP-1 ratio on days 1 and 5 in the ACL, the medial meniscus and the lateral
      meniscus. The expression of TIMP-1 mRNA was not significantly different between
      the ACL-T and CAM groups. CONCLUSIONS: The study results suggested that
      controlling abnormal movement inhibited the inflammatory reaction in intra
      articular tissues after ACL injury. This reaction was down-regulated in intra
      articular tissues in the CAM group. Abnormal joint control caused prolonged
      inflammation and inhibited remodeling during the acute phase of ACL rupture.

PMID- 29843673
TI  - Early rehabilitation for volumetric muscle loss injury augments endogenous
      regenerative aspects of muscle strength and oxidative capacity.
AB  - BACKGROUND: Volumetric muscle loss (VML) injuries occur due to orthopaedic trauma
      or the surgical removal of skeletal muscle and result in debilitating long-term
      functional deficits. Current treatment strategies do not promote significant
      restoration of function; additionally appropriate evidenced-based practice
      physical therapy paradigms have yet to be established. The objective of this
      study was to develop and evaluate early rehabilitation paradigms of passive range
      of motion and electrical stimulation in isolation or combination to understand
      the genetic and functional response in the tissue remaining after a multi-muscle
      VML injury. METHODS: Adult male mice underwent an ~ 20% multi-muscle VML injury
      to the posterior compartment (gastrocnemius, soleus, and plantaris muscle)
      unilaterally and were randomized to rehabilitation paradigm twice per week
      beginning 2 days post-injury or no treatment. RESULTS: The most salient findings
      of this work are: 1) that the remaining muscle tissue after VML injury was
      adaptable in terms of improved muscle strength and mitigation of stiffness; but
      2) not adaptable to improvements in metabolic capacity. Furthermore, biochemical
      (i.e., collagen content) and gene (i.e., gene arrays) assays suggest that
      functional adaptations may reflect changes in the biomechanical properties of the
      remaining tissue due to the cellular deposition of non-contractile tissue in the
      void left by the VML injury and/or differentiation of gene expression with early
      rehabilitation. CONCLUSIONS: Collectively this work provides evidence of genetic
      and functional plasticity in the remaining skeletal muscle with early
      rehabilitation approaches, which may facilitate future evidenced-based practice
      of early rehabilitation at the clinical level.

PMID- 29843674
TI  - Decreased choroidal thickness in vitiligo patients.
AB  - BACKGROUND: Vitiligo is a disease characterized by depigmented macules and
      patches that occur as a result of the loss of functional melanocytes from the
      affected skin through a mechanism which has not been elucidated yet. Destruction
      of pigment cells in vitiligo may not remain limited to the skin; the eyelashes,
      iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be
      affected. This study aims to compare the choroidal thickness of patients with and
      without vitiligo using optical coherence tomography (OCT). METHODS: Spectral
      domain optical coherence tomography (SD-OCT) (Retina Scan Advanced RS-3000 NIDEK,
      Japan) instrument (with lambda = 840 nm, 27,000 A-scans/second and 5 MUm axial
      resolution) was used for the imaging. Statistical analysis was performed using
      SPSS 21.0 software package. RESULTS: In all values except optic nevre area
      measurements, the choroidal thickness of all vitiligo patients was found out to
      be thinner compared to the control group. CONCLUSIONS: In vitiligo, the choroidal
      thickness may be affected by the loss of melanocytes.

PMID- 29843675
TI  - Mixed pneumonic plague and nosocomial MDR-bacterial infection of lung: a rare
      case report.
AB  - BACKGROUND: Plague is a life-threatening disease caused by the bacterium,
      Yersinia pestis. Madagascar is the leading country for human plague cases
      worldwide. Human plague is a serious disease, particularly in its septicaemic and
      pneumonic forms. We report a case of pneumonic plague co-infected by a MDR
      Stenotrophomonas maltophilia. CASE PRESENTATION: A 24 year-old man originated
      from Soavinandriana, a plague focus, felt uneasy and developed high fever with
      chills. He started treatment by himself, by private medical care and by a
      traditional healer for nine days moving several times from place to place. His
      condition had deteriorated when he presented to a district hospital with a
      syndrome of dyspnea, bronchial rale and altered state of consciousness. Two days
      later, plague diagnosis, performed as a last resort, revealed a positive F1
      antigen on rapid diagnostic test. Additional tests (pla PCR and plague serology)
      evidenced a Y. pestis infection. However, streptomycin treatment did not achieve
      a complete recovery as the course of disease was complicated by the presence of
      MDR-S. maltophilia in his lung. This opportunistic infection could have been
      favored by an immunosuppression due to Y. pestis pulmonary infection and probably
      been acquired during his stay at a District Hospital. He was treated with a
      combination of ciprofloxacin and gentamycin and recovered fully. CONCLUSIONS:
      Pneumonic plague infection may promote another virulent or avirulent bacterial
      infection particularly when it is not initially suspected. However, coinfection
      is rarely described and its occurrence frequency is unknown. In middle or low
      resources areas, which is the case of most plague endemic countries, control and
      prevention of infections in health facilities is not optimal. Co-infection with
      an opportunistic pathogen agent, such as S. maltophilia, is a risk which must not
      be disregarded as demonstrated by this case report. When deciding of a national
      control strategy, it should be taken into account in the choice of the first line
      treatment.

PMID- 29843676
TI  - Predictors of medication adherence among patients with severe psychiatric
      disorders: findings from the baseline assessment of a randomized controlled trial
      (Tecla).
AB  - BACKGROUND: Schizophrenia and bipolar disorder are characterized by a high
      disease burden. Antipsychotic medication is an essential part of the treatment.
      However, non-adherence is a major problem. Our aim was to examine potential
      determinants of non-adherence for patients with severe mental disorders. METHODS:
      Baseline data of the study "Post stationary telemedical care of patients with
      severe psychiatric disorders" (Tecla) were used. Medication adherence was
      assessed with the Medication Adherence Report Scale German version (MARS-D). A
      logistic regression was calculated with age, sex, education, employment status,
      level of global functioning, social support and intake of typical and atypical
      antipsychotics as predictors. RESULTS: N = 127 participants were included in the
      analysis (n = 73 men, mean age 42 years). The mean MARS-D Score was 23.4 (SD
      2.5). The most common reason for non-adherence was forgetting to take the
      medicine. Significant positive determinants for adherence were older age (OR
      1.02, 95% CI 1.011-1.024, p < 0.0001), being employed (OR 2.46, 95% CI 1.893
      3.206, p < 0.0001), higher level of global functioning (overall measure of how
      patients are doing) (OR 1.02, 95% CI 1.012-1.028, p < 0.0001), having social
      support (OR 1.02, 95% CI 1.013-1.026, p < 0.0001), and intake of typical
      antipsychotics (OR 2.389, 95% CI 1.796-3.178, p < 0.0001). A negative determinant
      was (female) sex (OR 0.73, 95% CI 0.625-0.859, p = 0.0001). CONCLUSIONS:
      Especially employment, functioning and social support could be promising targets
      to facilitate adherence in patients with schizophrenia or bipolar disorder. TRIAL
      REGISTRATION: This study is retrospectively registered at the German Clinical
      Trials Register with the trial registration number DRKS00008548 at 21/05/2015.

PMID- 29843677
TI  - Stability of gene expression by primary bronchial epithelial cells over
      increasing passage number.
AB  - BACKGROUND: An increasing number of studies using primary human bronchial
      epithelial cells (BECs) have reported intrinsic differences in the expression of
      several genes between cells from asthmatic and non-asthmatic donors. The
      stability of gene expression by primary BECs with increasing cell passage number
      has not been well characterized. METHODS: To determine if expression by primary
      BECs from asthmatic and non-asthmatic children of selected genes associated with
      airway remodeling, innate immune response, immunomodulatory factors, and markers
      of differentiated airway epithelium, are stable over increasing cell passage
      number, we studied gene expression patterns in passages 1, 2, 3, 4, and 5 BECs
      from asthmatic (n = 6) and healthy (n = 6) subjects that were differentiated at
      an air-liquid interface. RNA was harvested from BECs and RT-PCR was performed for
      TGFbeta1, TGFbeta2, activin A, FSTL3, MUC5AC, TSLP, IL-33, CXCL10, IFIH1, p63,
      KT5, TUBB4A, TJP1, OCLN, and FOXJ1. RESULTS: Expression of TGFbeta1, TGFbeta2,
      activin A, FSTL3, MUC5AC, CXCL10, IFIH1, p63, KT5, TUBB4A, TJP1, OCLN, and FOXJ1
      by primary BECs from asthmatic and healthy children was stable with no
      significant differences between passages 1, 2 and 3; however, gene expression at
      cell passages 4 and 5 was significantly greater and more variable compared to
      passage 1 BECs for many of these genes. IL-33 and FOXJ1 expression was also
      stable between passages 1 through 3, however, expression at passages 4 and 5 was
      significantly lower than by passage 1 BECs. TSLP, p63, and KRT5 expression was
      stable across BEC passages 1 through 5 for both asthmatic and healthy BECs.
      CONCLUSIONS: These observations illustrate the importance of using BECs from
      passage <=3 when studying gene expression by asthmatic and non-asthmatic primary
      BECs and characterizing the expression pattern across increasing cell passage
      number for each new gene studied, as beyond passage 3 genes expressed by primary
      BECs appear to less accurately model in vivo airway epithelial gene expression.

PMID- 29843678
TI  - When helping helps: exploring health benefits of cancer survivors participating
      in for-cause physical activity events.
AB  - BACKGROUND: Over 15.5 million Americans live with cancer and 5-year survival
      rates have risen to 69%. Evidence supports important health benefits of regular
      physical activity for cancer survivors, including increased strength and quality
      of life, and reduced fatigue, recurrence, and mortality. However, physical
      activity participation among cancer survivors remains low. Cancer organizations
      provide various resources and support for cancer survivors, including emotional,
      instrumental, informational, and appraisal support. Many cancer organizations,
      like the LIVESTRONG Foundation, support the cancer community by sponsoring and
      hosting for-cause physical activity events, providing opportunities for anyone
      (including cancer survivors) to "help"/support those living with cancer. The
      concept of helping others has been positively related with wellbeing, physical
      activity, and multiple health behaviors for those helping. However, the role of
      helping others has not been examined in the context of being physically active to
      help others or its relationship with overall physical activity and quality of
      life among those helping. Therefore, we developed a path model to examine
      relationships between cancer survivors' (1) desire to help others with cancer,
      (2) physically active LIVESTRONG participation to help others, (3) regular
      physical activity engagement, and (4) quality of life. METHODS: In 2010, 3257
      cancer survivors responded to an online survey sent to all people involved with
      the LIVESTRONG organization at any level. The hypothesized path model was tested
      using path analysis (Mplus 8). RESULTS: After list-wise deletion of missing
      responses, our final sample size was 3122 (61.8% female, mean age: 48.2 years [SD
      = 12.7]). Results indicated that the model yielded perfect fit indexes.
      Controlling for age, sex, income, and survivorship length, desire to help was
      positively related with physically active LIVESTRONG participation (beta = .11, p
      < .001), which was positively related with regular physical activity (beta = .30,
      p < .001), and regular physical activity was positively related with quality of
      life (beta = .194, p < .001). CONCLUSIONS: Results suggest that cancer survivors
      can benefit from participating in for-cause physical activity events, including
      more regular physical activity. Researchers need to further investigate the role
      of helping others when examining health behaviors and outcomes, and cancer
      organizations should continue encouraging cancer survivors to help others by
      participating in physical activity events.

PMID- 29843679
TI  - Direct-acting antiviral treatment in real world patients with hepatitis C not
      associated with psychiatric side effects: a prospective observational study.
AB  - BACKGROUND: Treatment of Hepatitis C virus (HCV) infection has evolved from
      interferon (IFN)-based treatments to direct-acting antivirals (DAAs). Patients
      with HCV have an elevated psychiatric morbidity (including substance abuse) and
      patients with such comorbidity have often been excluded from treatment with IFN.
      To date, little is known about psychiatric adverse effects of DAA-based regimens.
      We therefore aimed to study the psychiatric side effects of new IFN-free
      treatment for HCV (including depressive symptoms and sleep) in real world
      patients also including those with a history of psychiatric diagnosis, substance
      abuse or drug dependence. METHODS: Consecutive patients were monitored during
      treatment with three of the latest DAA agents (sofosbuvir, simeprevir and
      daclatasvir). Repeated expert psychiatric assessments from baseline to 12 weeks
      post-treatment were performed with the Structured Clinical Interview for DSM-IV
      Axis I Disorders (SCID-I) clinical version and the self-report versions of the
      Montgomery Asberg Depression Rating Scale (MADRS-S) and the Pittsburgh Sleep
      Quality Index (PSQI). Friedman's test was performed to calculate differences in
      the MADRS-S and PSQI over time. In a post-hoc analysis Wilcoxon's test was used
      to compare baseline depressive symptoms with those at post-treatment. Spearman's
      rank correlation test was conducted in another post-hoc analysis to evaluate the
      correlation between symptoms of depression and HCV viral load at baseline.
      RESULTS: At baseline, 15/17 patients (88%) had a history of any psychiatric
      diagnosis; 11 (65%) had a history of substance abuse or dependence; and 11 (65%)
      had previously been treated with IFN and six of those had experienced psychiatric
      side effects. There was no correlation between depressive symptoms and HCV viral
      load at baseline. Symptoms of depression did not increase during DAA treatment
      and were lower 12 weeks post-treatment compared with baseline: MADRS-S 10.7 vs.
      8.3 (p = 0.01). This observation held when excluding patients taking
      antidepressant medication. Sleep quality did not significantly change during
      treatment. Adherence to treatment was estimated to 95% and sustained virological
      response was 88%. CONCLUSIONS: Despite high psychiatric morbidity, including
      previous substance abuse, patients successfully completed DAA treatment without
      increasing depressive symptoms or sleep disturbance. Symptoms of depression were
      significantly reduced 12 weeks after DAA treatment.

PMID- 29843680
TI  - Outcomes and early revision rate after medial unicompartmental knee arthroplasty:
      prospective results from a non-designer single surgeon.
AB  - BACKGROUND: This prospective study evaluates outcomes and reoperation rates for
      unicompartmental knee arthroplasty (UKA) from a single non-designer surgeon using
      relatively extended criteria of degenerative changes of grade 2 or above in
      either or both non-operated compartments. METHODS: 187 consecutive medial mobile
      bearing UKA implants were included after history, clinical assessment and
      radiological evaluation. 91 patients had extended clinical outcomes. Post
      operative assessment included functional scoring with the Oxford Knee Score (OKS)
      and radiographic review. Survivorship curves were constructed using the life
      table method, with 95% confidence intervals calculated using Rothman's equation.
      Separate endpoints were examined: revision for any reason and revision for
      confirmed loosening. RESULTS: The mean follow-up was 3.5 years. The pre-operative
      OKS improved from a mean of 21.2 to 38.9 (Mann-Whitney U Test, p = < 0.001).
      Twelve Patients required further operations including 9 revisions. No patients
      developed deep infection and no surviving implants were loose radiographically.
      Survivorship at 7 years with endpoints of re-operation, revision and aseptic
      loosening at surgery or radiographically was 88.4% (95% CI 79.6-93.7), 93.1% (95%
      CI 85.5-96.9) and 97.3% (95% CI 91.2-99.2) respectively. The presence of pre
      operative mild contralateral tibiofemoral or any extent of patellofemoral joint
      degeneration was of no consequence. DISCUSSION: The indications for UKA are being
      expanded to include patients with greater deformity, more advanced disease in the
      patellofemoral joint and even certain features in the lateral compartment
      indicative of an anteromedial pattern of osteoarthritis (OA). However, much of
      the supporting literature remains available only from designer centres. This
      study represents a group of patients with what we believe to be wider
      indications, along with decisions to treat made on clinical grounds and
      radiographs alone. CONCLUSION: This study shows comparable clinical outcomes of
      UKA for extended indications from a high volume, high-usage non-designer unit.

PMID- 29843681
TI  - Prevalence and risk factors of testicular microlithiasis in patients with
      hypospadias: a retrospective study.
AB  - BACKGROUND: It has been described that the incidence of testicular microlithiasis
      is high in several congenital disorders which may be associated with testicular
      impairment and infertility. Several reports have shown that a prepubertal or
      pubertal hormonal abnormality in the pituitary-gonadal axis was identified in
      some patients with hypospadias that is one of the most common disorders of sex
      development. However, exact prevalence or risk factors of testicular
      microlithiasis in patients with hypospadias have not reported so far. In the
      present study, to clarify the prevalence and risk factors of testicular
      microlithiasis in patients with hypospadias, a retrospective chart review was
      performed. METHODS: Children with hypospadias who underwent testicular
      ultrasonography between January 2010 and April 2016 were enrolled in the present
      study. Severity of hypospadias was divided into mild and severe. The prevalence
      and risk factors of testicular microlithiasis or classic testicular
      microlithiasis were examined. RESULTS: Of 121 children, mild and severe
      hypospadias were identified in 66 and 55, respectively. Sixteen children had
      undescended testis. Median age at ultrasonography evaluation was 1.7 years old.
      Testicular microlithiasis and classic testicular microlithiasis were documented
      in 17 children (14.0%) and 8 (6.6%), respectively. Logistic regression analysis
      revealed that presence of undescended testis was only a significant factor for
      testicular microlithiasis and classic testicular microlithiasis. The prevalence
      of testicular microlithiasis or classic testicular microlithiasis was
      significantly higher in children with undescended testis compared to those
      without undescended testis (testicular microlithiasis; 43.8% versus 9.5% (p =
      0.002), classic testicular microlithiasis; 37.5% versus 1.9% (p < 0.001).
      CONCLUSIONS: The current study demonstrated that the presence of undescended
      testis was only a significant risk factor for testicular microlithiasis or
      classic testicular microlithiasis in patients with hypospadias. As co-existing
      undescended testis has been reported as a risk factor for testicular dysfunction
      among patients with hypospadias, the current findings suggest that testicular
      microlithiasis in children with hypospadias may be associated with impaired
      testicular function. Conversely, patients with isolated HS seem to have lower
      risks for testicular impairment. Further investigation with longer follow-up will
      be needed to clarify these findings.

PMID- 29843682
TI  - Changes in attitudes towards hastened death among Finnish physicians over the
      past sixteen years.
AB  - BACKGROUND: The ethics of hastened death are complex. Studies on physicians'
      opinions about assisted dying (euthanasia or assisted suicide) exist, but changes
      in physicians' attitudes towards hastened death in clinical decision-making and
      the background factors explaining this remain unclear. The aim of this study was
      to explore the changes in these attitudes among Finnish physicians. METHODS: A
      questionnaire including hypothetical patient scenarios was sent to 1182 and 1258
      Finnish physicians in 1999 and 2015, respectively. Two scenarios of patients with
      advanced cancer were presented: one requesting an increase in his morphine dose
      to a potentially lethal level and another suffering a cardiac arrest. Physicians'
      attitudes towards assisted death, life values and other background factors were
      queried as well. The response rate was 56%. RESULTS: The morphine dose was
      increased by 25% and 34% of the physicians in 1999 and 2015, respectively (p <
      0.001). Oncologists approved the increase most infrequently without a significant
      change between the study years (15% vs. 17%, p = 0.689). Oncological specialty,
      faith in God, female gender and younger age were independent factors associated
      with the reluctance to increase the morphine dose. Euthanasia, but not assisted
      suicide, was considered less reprehensible in 2015 (p = 0.008). In both years,
      most physicians (84%) withheld cardiopulmonary resuscitation. CONCLUSION: Finnish
      physicians accepted the risk of hastening death more often in 2015 than in 1999.
      The physicians' specialty and many other background factors influenced this
      acceptance. They also regarded euthanasia as less reprehensible now than they did
      16 years ago.

PMID- 29843683
TI  - Does hallux valgus impair physical function?
AB  - BACKGROUND: The relationships between radiographic hallux valgus (HV) and various
      physical functions independent of knee osteoarthritis (KOA) were examined among
      residents of a mountain village in Japan. METHODS: Study participants were
      recruited from mountain village residents aged >=50 years. Participants' height,
      weight, and body mass index (BMI) were measured, and baseline data, including
      age, sex, and foot pain, were obtained using interviews and questionnaires.
      Radiography of the feet and knees was performed to assess the presence of HV (HV
      angle >=20 degrees ) and KOA (Kellgren-Lawrence grade >= II). Grip strength, 6-m
      walk at usual and maximum speeds, single-leg stance time, and stand up from a
      chair time were evaluated as physical function performance tests. Plantar
      pressure patterns were also examined. RESULTS: Moderate-severe HV (HV angle >=30
      degrees), impaired grip strength and maximum walking speed, and painful HV
      reduced usual and maximum walking speeds independent of KOA. Hallux plantar
      pressure decreased according to the HV angle. Hallux plantar pressure was
      significantly lower in painful HV than in the no HV feet or painless HV.
      CONCLUSIONS: Moderate-severe HV deformity and HV-related pain impaired physical
      function independent of KOA. By controlling the pain and severe deformity of HV
      by treatments such as surgery, the physical function of HV patients might be
      improved.

PMID- 29843684
TI  - The production of a recombinant tandem single chain fragment variable capable of
      binding prolamins triggering celiac disease.
AB  - BACKGROUND: Celiac disease (CD) is one of the most common food-related chronic
      disorders. It is mediated by the dietary consumption of prolamins, which are
      storage proteins of different grains. So far, no therapy exists and patients are
      bound to maintain a lifelong diet to avoid symptoms and long-term complications.
      To support those patients we developed a tandem single chain Fragment variable
      (tscFv) acting as a neutralizing agent against prolamins. We recombinantly
      produced this molecule in E. coli, but mainly obtained misfolded product
      aggregates, so-called inclusion bodies, independent of the cultivation strategy
      we applied. RESULTS: In this study, we introduce this novel tscFv against CD and
      present our strategy of obtaining active product from inclusion bodies. The
      refolded tscFv shows binding capabilities towards all tested CD-triggering
      grains. Compared to a standard polyclonal anti-PT-gliadin-IgY, the tscFv displays
      a slightly reduced affinity towards digested gliadin, but an additional affinity
      towards prolamins of barley. CONCLUSION: The high binding specificity of tscFv
      towards prolamin-containing grains makes this novel molecule a valuable candidate
      to support patients suffering from CD in the future.

PMID- 29843685
TI  - Life after pelvic organ prolapse surgery: a qualitative study in Amhara region,
      Ethiopia.
AB  - BACKGROUND: Women living in resource constrained settings often have limited
      knowledge of and access to surgical treatment for pelvic organ prolapse.
      Additionally, little is known about experiences during recovery periods or about
      the reintegration process for women who do gain access to medical services,
      including surgery. This study aimed to explore women's experiences related to
      recovery and reintegration after free surgical treatment for pelvic organ
      prolapse in a resource-constrained setting. METHODS: The study had a qualitative
      design and used in-depth interviews in the data collection with a purposive
      sample of 25 participants, including 12 women with pelvic organ prolapse.
      Recruitment took place at the University of Gondar Hospital, Ethiopia, where
      women with pelvic organ prolapse had been admitted for free surgical treatment.
      In-depth interviews were carried out with women at the hospital prior to surgery
      and in their homes 5-9 months following surgery. Interviews were also conducted
      with health-care providers (8), representatives from relevant organizations (3),
      and health authorities (2). The fieldwork was carried out in close collaboration
      with a local female interpreter. RESULTS: The majority of the women experienced a
      transformation after prolapse surgery. They went from a life dominated by fear of
      disclosure, discrimination, and divorce due to what was perceived as a shameful
      and strongly prohibitive condition both physically and socially, to a life of
      gradually regained physical health and reintegration into a social life. The
      strong mobilization of family-networks for most of the women facilitated work
      related help and social support during the immediate post-surgery period as well
      as on a long-term basis. The women with less extensive social networks expressed
      greater challenges, and some struggled to meet their basic needs. All the women
      openly disclosed their health condition after surgery, and several actively
      engaged in creating awareness about the condition. CONCLUSIONS: Free surgical
      treatment substantially improved the health and social life for most of the study
      participants. The impact of the surgery extended to the communities in which the
      women lived through increased openness and awareness and thus had the potential
      to ensure increased disclosure among other women who suffer from this treatable
      condition.

PMID- 29843686
TI  - Experiences of being screened for intimate partner violence during pregnancy: a
      qualitative study of women in Japan.
AB  - BACKGROUND: Intimate partner violence (IPV) is physical, sexual or psychological
      violence by a current or former intimate partner. IPV threatens women's health,
      and during pregnancy women are more vulnerable to violence. Therefore, IPV
      screening has been recommended during antenatal care; however, health care
      providers have expressed concern about the negative impact on women and therefore
      have been reluctant in conducting IPV screening. Consequently our objective was
      to investigate pregnant women's experiences of reading and completing an IPV
      screening questionnaire. METHODS: Semi-structured interviews were conducted with
      postpartum women who had received IPV screening during pregnancy to investigate
      their experiences using the IVP Violence Against Women Screen (VAWS). Qualitative
      data were analyzed based on content analysis. RESULTS: A total of 43 women
      participated in this study. There were eight (18.6%) women positive for IPV
      screening during pregnancy. Content analysis for all participants revealed three
      themes: necessity, acceptability and optimality. 'Necessity' referred to benefits
      for women from IPV screening, and was supported by three categories: 'redefining
      the relationship', 'promoting IPV awareness' and 'opportunity to initiate
      support'. 'Acceptability' of IPV screening was also supported by three
      categories: 'comfortable', 'quickly completed' and 'difficulty'. 'Optimality'
      meant IPV screening during pregnancy was appropriate timing for women who had
      been screened as either positive or negative. CONCLUSIONS: The majority of women,
      including women experiencing IPV, had positive responses to IPV screening during
      pregnancy. Future diffusion of IPV screening requires safe environments for IPV
      screening and improved awareness of health care providers towards IPV.

PMID- 29843687
TI  - Sexual initiation and associated factors among young women in West Shoa, Ambo
      Town, Ethiopia: a community-based cross-sectional study.
AB  - BACKGROUND: For physiological as well as behavioral reasons, sexual debut
      increases young individuals' risk for infection with sexually transmitted
      infection including HIV. It is fundamental to recognize the factors related to
      sexual debut in a broader context for designing and implementing effective
      interventions targeting youth. METHODS: Community-based cross-sectional study was
      employed from January to May, 2013 among females of Ambo town. A multistage
      sampling technique was applied. The participants were selected using simple
      random sampling technique. Face to face interview using structured and pretested
      questionnaires were used to collect thedata from the study participants.
      Bivariate and multivariate logistic regression analysis was used to determine the
      predictors of sexual initiation. RESULTS: Three hundred seventeen (49.9%) of the
      respondents have ever had sex. The mean age at first sexual initiation was 16.6
      (SD +/-2.3) years. Being in age group 20-24 [Adjusted Odds Ratio (AOR) & (95% CI)
      = 2.75 (1.74, 4.34)], Educational level [AOR& (95% CI) = 0.20 (0.08, 0.48)],
      being in school [AOR& (95% CI) = 0.19 (0.11, 0.33)], having paid job [AOR& (95%
      CI) = 2.20 (1.19, 4.07)], peer pressure [AOR& (95% CI) = 3.20 (2.08, 4.94)],
      alcohol consumption [AOR& (95% CI) = 2.17 (1.43, 3.28)], and pornographic
      materials [AOR& (95% CI) = 2.27 (1.43, 3.61)] had significant association with
      sexual initiation. CONCLUSION: Substantial numbers of females had started sexual
      activity that might expose them to different reproductive health problems. In
      general age group, peer pressure, alcohol consumption and watching pornographic
      materials were found to be predictors for the sexual debut. Therefore, building
      life skills, establishing youth friendly clubs should be intensified.

PMID- 29843688
TI  - Huatuo Zaizao pill ameliorates cognitive impairment of APP/PS1 transgenic mice by
      improving synaptic plasticity and reducing Abeta deposition.
AB  - BACKGROUND: It is well known that Alzheimer's disease (AD) is a progressive
      neurodegenerative disease characterized by memory deficits and cognitive decline.
      Amyloid-beta (Abeta) deposition and synaptic dysfunction play important roles in
      the pathophysiology of Alzheimer's disease (AD). The Huatuo Zaizao pill (HT) is a
      Traditional Chinese Medicine (TCM) that has been used clinically for many years
      in China, mainly for post-stroke rehabilitation and cognitive decline; however,
      the mechanism of cognitive function is not clear. In this study, we investigated
      the effect of HT on hippocampal synaptic function, Amyloid-beta (Abeta)
      deposition in APP/PS1 AD transgenic mice. METHOD: Six-month-old APP/PS1
      transgenic (Tg) mice were randomly divided into control, HT-treated, and
      memantine (MEM)-treated groups. Then, these groups were orally administered
      vehicle (for the control), HT (0.25 g/kg) and MEM (5 mg/kg) respectively for 4
      weeks. The Morris water maze, Novel Object Recognition, and Open field tests were
      used to assess cognitive behavioral changes. We evaluated the effects of HT on
      neuronal excitability, membrane ion channel activity, and synaptic plasticity in
      acute hippocampal slices by combining electrophysiological extracellular tests.
      Synaptic morphology in the hippocampus was investigated by electron microscopy.
      Western blotting was used to assess synaptic-associated protein and Abeta
      production and degrading levels. Immunofluorescence staining was used to
      determine the relative integrated density. RESULTS: HT can ameliorate hippocampus
      dependent memory deficits and improve synaptic dysfunction by reversing LTP
      impairment in APP/PS1 transgenic mice. Moreover, HT reduces amyloid plaque
      deposition by regulating alpha-secretase and gamma-secretase levels. CONCLUSION:
      HT can improve the learning and memory function of APP/PS1 transgenic mice by
      improving synaptic function and reducing amyloid plaque deposition.

PMID- 29843689
TI  - Widening interest, widening participation: factors influencing school students'
      aspirations to study medicine.
AB  - BACKGROUND: Under-representation of some socio-economic groups in medicine is
      rooted in under-representation of those groups in applications to medical school.
      This study aimed to explore what may deter school-age children from applying to
      study medicine. METHODS: Workshops were undertaken with school students aged 16
      17 years ('Year 12', n = 122 across three workshops) and 13-14 years ('Year 9', n
      = 295 across three workshops). Workshops used a variety of methods to identify
      and discuss participants' perceptions of medicine, medical school and the
      application process. Year 12 workshops focused on applications and medical
      school, while Year 9 took a broader approach reflecting their relative distance
      from applying. Subsequent workshops were informed by the findings of earlier
      ones. RESULTS: The main finding was that potential applicants had limited
      knowledge about medicine and medical school in several areas. Older students
      would benefit from accessible information about medical degrees and application
      processes, access to work experience opportunities and personal contact with
      medical students and junior doctors, particularly those from a similar
      background. Younger students demonstrated a lack of awareness of the breadth of
      medical careers and a limited understanding of what medicine encompasses. Many
      Year 9 students were attracted by elements of practice which they did not
      associate with medicine, such as 'talking to people with mental health problems'.
      An exercise addressing this elicited an increase in their interest in medicine.
      These issues were identified by participants as being more marked for those
      without knowledgeable support at home or school. It was apparent that school
      teachers may not be equipped to fill these knowledge gaps. CONCLUSION: Gaps in
      knowledge and support may reflect the importance of 'social capital' in
      facilitating access to medical school. Medical schools could act as hubs to
      introduce students to resources which are essential for widening participation.
      Outreach and support to schools may ensure that fundamental knowledge gaps are
      equitably addressed for all prospective applicants. More generally, a focus on
      medicine which under-emphasises aspects of medical practice involving
      communication may deter some students and have longer term impact on recruitment
      to careers including general practice and psychiatry.

PMID- 29843690
TI  - Effects of dental treatment and systemic disease on oral health-related quality
      of life in Korean pediatric patients.
AB  - BACKGROUND: The findings that not only dental caries but also systemic disease
      can exert a negative effect on oral health-related quality of life (OHRQoL), and
      that dental treatment can improve OHRQoL have been confirmed in multiple studies.
      The purpose of this study is to investigate the impact of dental treatment on
      OHRQoL of Korean pediatric patients and the differences in OHRQoL between
      patients with and without systemic disease. METHODS: All the primary caregivers
      of pediatric patients who underwent dental treatments under either general
      anesthesia or intravenous deep sedation at Seoul National University Dental
      Hospital completed abbreviated versions of the Child Oral Health Impact Profile
      (COHIP-14) and Family Impact Scale (FIS-12) surveys on OHRQOL pre- and post
      treatment (average: 2.4 +/- 1.7 months after dental treatment). This is a case
      control study with patients divided into two groups according to the presence or
      absence of systemic disease. RESULTS: Data from 93 pediatric patients (46 male
      and 47 female, average patient age: 5.0 +/- 3.4 years) were analyzed to compare
      OHRQoL before and after treatment with the Wilcoxon signed-rank test and to
      calculate the effect size using Cohen's d. All of the patients exhibited an
      improvement in OHRQoL (COHIP-14: p <  0.001, effect size = 1.0; FIS-12: p < 
      0.001, effect size = 0.7). Patients with systemic diseases demonstrated lower
      OHRQoL in both pre- and post-treatment surveys than patients without systemic
      diseases (Wilcoxon Rank-sum test, both COHIP-14 and FIS-12: p <  0.05). The COHIP
      14 appears to have a greater impact on the FIS-12 in patients with systemic
      disease than those without (explanatory power of 65.3 and 44.6%, respectively).
      CONCLUSIONS: Based on the primary caregivers' perceptions, dental treatment can
      improve the OHRQoL in Korean pediatric patients. Systemic disease results in a
      reduced OHRQoL, and the awareness of patients' oral health appeared to have a
      greater impact on OHRQoL for family members of patients with a systemic disease.
      TRIAL REGISTRATION: KCT0002473 (Clinical Research Information Service, Republic
      of Korea) and 22 Sep 2017, retrospectively registered.

PMID- 29843691
TI  - Impacts of online and group perinatal education: a mixed methods study protocol
      for the optimization of perinatal health services.
AB  - BACKGROUND: Prenatal education is a core component of perinatal care and services
      provided by health institutions. Whereas group prenatal education is the most
      common educational model, some health institutions have opted to implement online
      prenatal education to address accessibility issues as well as the evolving needs
      of future parents. Various studies have shown that prenatal education can be
      effective in acquisition of knowledge on labour and delivery, reducing
      psychological distress and maximising father's involvement. However, these
      results may depend on educational material, organization, format and content.
      Furthermore, the effectiveness of online prenatal education compared to group
      prenatal education remains unclear in the literature. This project aims to
      evaluate the impacts of group prenatal education and online prenatal education on
      health determinants and users' health status, as well as on networks of perinatal
      educational services maintained with community-based partners. METHODS: This
      multipronged mixed methods study uses a collaborative research approach to
      integrate and mobilize knowledge throughout the process. It consists of: 1) a
      prospective cohort study with quantitative data collection and qualitative
      interviews with future and new parents; and 2) a multiple case study integrating
      documentary sources and interviews with stakeholders involved in the
      implementation of perinatal information service networks and collaborations with
      community partners. Perinatal health indicators and determinants will be compared
      between prenatal education groups (group prenatal education and online prenatal
      education) and standard care without these prenatal education services (control
      group). DISCUSSION: This study will provide knowledge about the impact of online
      prenatal education as a new technological service delivery model compared to
      traditional group prenatal education. Indicators related to the complementarity
      of these interventions and those available in community settings will refine our
      understanding of regional perinatal services networks. Results will assist
      decision-making regarding service organization and delivery models of prenatal
      education services. PROTOCOL VERSION: Version 1 (February 9 2018).

PMID- 29843692
TI  - Quality improvement strategies at primary care level to reduce inequalities in
      diabetes care: an equity-oriented systematic review.
AB  - BACKGROUND: There is evidence that disparities exist in diabetes prevalence,
      access to diabetes care, diabetes-related complications, and the quality of
      diabetes care. A wide range of interventions has been implemented and evaluated
      to improve diabetes care. We aimed to review trials of quality improvement (QI)
      interventions aimed to reduce health inequities among people with diabetes in
      primary care and to explore the extent to which experimental studies addressed
      and reported equity issues. METHODS: Pubmed, EMBASE, CINAHL, and the Cochrane
      Library were searched to identify randomized controlled studies published between
      January 2005 and May 2016. We adopted the PROGRESS Plus framework, as a tool to
      explore differential effects of QI interventions across sociodemographic and
      economic factors. RESULTS: From 1903 references fifty-eight randomized trials met
      the inclusion criteria (with 17.786 participants), mostly carried out in USA. The
      methodological quality was good for all studies. Almost all studies reported the
      age, gender/sex and race distribution of study participants. The majority of
      trials additionally used at least one further PROGRESS-Plus factor at baseline,
      with education being the most commonly used, followed by income (55%). Large
      variation was observed between these studies for type of interventions, target
      populations, and outcomes evaluated. Few studies examined differential
      intervention effects by PROGRESS-plus factors. Existing evidence suggests that
      some QI intervention delivered in primary care can improve diabetes-related
      health outcomes in social disadvantaged population subgroups such as ethnic
      minorities. However, we found very few studies comparing health outcomes between
      population subgroups and reporting differential effect estimates of QI
      interventions. CONCLUSIONS: This review provides evidence that QI interventions
      for people with diabetes is feasible to implement and highly acceptable. However,
      more research is needed to understand their effective components as well as the
      adoption of an equity-oriented approach in conducting primary studies. Moreover,
      a wider variety of socio-economic characteristics such as social capital, place
      of residence, occupation, education, and religion should be addressed.

PMID- 29843693
TI  - First right lobe living-donor hepatectomy after sleeve gastrectomy.
AB  - BACKGROUND: Obesity presents one of the leading causes of many chronic liver
      disorders and injuries. Nowadays, non-alcoholic steatohepatitis (NASH)
      demonstrates a challenging issue for the global health system. NASH can progress
      to life-threatening conditions such as cirrhosis and hepatocellular or cholangio
      carcinoma. Currently, NASH cirrhosis is a major indication for liver transplant
      (LT). CASE PRESENTATION: We present the case of a 37 year-old male who has lost
      74 kg after undergoing successful laparoscopic sleeve gastrectomy (SG) four years
      ago. Recently, he underwent right hepatectomy in the course of living-donor liver
      transplantation for his sick father in our clinic. Before the SG was conducted
      four years ago, his weight was at 157 kg and his Body Mass Index (BMI) at 49
      kg/m2. At that time, Ultrasound examination showed severe fatty liver changes and
      intraoperative inspection of the liver was consistent with that observation. At
      the time of surgery, he weighed 83 kg and his BMI was at 27 kg/m2. An effective
      weight reduction after bariatric surgery might protect NASH patients from further
      deterioration of their medical condition. CONCLUSION: To our knowledge, we report
      the first successful case of a right lobe living-donor hepatectomy in a patient
      who previously underwent successful laparoscopic sleeve gastrectomy (LSG).

PMID- 29843694
TI  - Cancer detection rate of prebiopsy MRI with subsequent systematic and targeted
      biopsy are superior to non-targeting systematic biopsy without MRI in biopsy
      naive patients: a retrospective cohort study.
AB  - BACKGROUND: To determine whether prebiopsy multiparametric magnetic resonance
      imaging (mpMRI) with subsequent systematic plus targeted biopsies for suspicious
      lesions improve prostate cancer detection compared with standard non-targeting
      systematic biopsies without mpMRI in biopsy-naive patients. METHODS: Patients who
      underwent their first prostate biopsy due to suspicion of prostate cancer were
      analyzed retrospectively to compare the biopsy outcomes between patients who
      received prebiopsy mpMRI (215 patients) and those who did not (281 patients).
      mpMRI was performed to determine pre-biopsy likelihood of the presence of
      prostate cancer using a three-point scale (1 = low level of suspicion, 2 =
      equivocal, and 3 = high level of suspicion). Systematic biopsies were performed
      in both groups. Targeted biopsies were added for a high level of suspicious
      lesions on mpMRI. All biopsies were performed by transperineal biopsy technique.
      After biopsy, Prostate Imaging Reporting and Data System ver. 2 (PIRADS-2)
      scoring was performed to describe the mpMRI findings and predictive value of
      PIRADS-2 was evaluated. RESULTS: The detection rate of total and clinically
      significant prostate cancer was significantly higher in patients who received
      prebiopsy mpMRI than in those who did not (55.3 and 46.0% vs. 42.0 and 35.2%,
      respectively; p = 0.004 and p = 0.016). The clinically insignificant prostate
      cancer detection rate was similar between the two groups (9.3% vs. 6.8%; p =
      0.32). Of 86 patients who underwent systematic plus targeted biopsy in the MRI
      cohort and were diagnosed with prostate cancer, seven patients were detected by
      addition of targeted biopsy whereas 29 patients were missed by targeted biopsy
      but detected by systematic biopsy. There was a correlation between the PIRADS-2
      and prostate cancer detection rate, and a receiver-operator curve analysis
      yielded an area under the curve of 0.801 (p <  0.0001). CONCLUSIONS: Prebiopsy
      mpMRI with subsequent systematic plus targeted biopsies for suspicious lesions
      can yield a higher cancer detection rate than non-targeting systematic biopsies.
      PIRADS-2 scoring is useful for predicting the biopsy outcome.

PMID- 29843695
TI  - Factors associated with low vs increased perceived mastery of clinical work over
      ten years of practice: a prospective study of Norwegian doctors.
AB  - BACKGROUND: A higher sense of mastery of doctors' clinical work could benefit not
      only their own mental health but also their work performance and patient care.
      However, we know little about factors associated with perceived mastery of
      clinical work among physicians. Our aim was therefore to study characteristics of
      those with stable low levels and of those with increased levels of mastery over a
      period of ten years of medical practice. METHODS: N = 631 doctors were surveyed
      in their final year of medical school in 1993/94 (T1) and 10 (T2), 15 (T3) and 20
      (T4) years later. Low and increased perceived mastery of clinical work were
      measured between T2, T3 and T4. Response rates for all items measuring low and
      increased mastery were 238/522 (46%) and 256/522 (49%) respectively. The
      following explanatory variables were included: demographics, medical school
      factors, personality and contextual work-related and non-work-related factors.
      RESULTS: N = 73 (31%) of the doctors reported stable low mastery from T2 to T4.
      The following variables were significantly associated with low mastery in the
      adjusted analyses: vulnerability (OR: 1.30, P < .000, CI: 1.12 to 1.50), drinking
      alcohol to cope with stress during medical school (OR: 2.66, P = .04, CI: 1.03 to
      6.85) and social support (OR: 0.78, P = .002, CI: 0.66 to 0.91). N = 39 (15%)
      reported increased mastery during the ten-year period from T2 to T4. Perceived
      job demands (OR: 0.66, P = .02, CI: 0.45 to 0.98) and taking up a leading
      position (OR: 3.04, P = .01, CI: 1.31 to 7.07) were associated with increased
      mastery after adjustment. CONCLUSIONS: Stable low sense of mastery over time is
      associated with having a vulnerable personality, a history of having used alcohol
      to cope with stress during medical school and lack of contemporary social
      support. Conversely, increased sense of mastery is associated with taking up a
      leading position and having the perception that job demands are decreasing over
      time. These findings indicate that perceived mastery of clinical work may not be
      a trait, but a state modifiable over time.

PMID- 29843696
TI  - Implementation of a patient-facing genomic test report in the electronic health
      record using a web-application interface.
AB  - BACKGROUND: Genomic medicine is emerging into clinical care. Communication of
      genetic laboratory results to patients and providers is hampered by the complex
      technical nature of the laboratory reports. This can lead to confusion and
      misinterpretation of the results resulting in inappropriate care. Patients
      usually do not receive a copy of the report leading to further opportunities for
      miscommunication. To address these problems, interpretive reports were created
      using input from the intended end users, patients and providers. This paper
      describes the technical development and deployment of the first patient-facing
      genomic test report (PGR) within an electronic health record (EHR) ecosystem
      using a locally developed standards-based web-application interface. METHODS: A
      patient-facing genomic test report with a companion provider report was
      configured for implementation within the EHR using a locally developed software
      platform, COMPASSTM. COMPASSTM is designed to manage secure data exchange, as
      well as patient and provider access to patient reported data capture and clinical
      display tools. COMPASSTM is built using a Software as a Service (SaaS) approach
      which exposes an API that apps can interact with. RESULTS: An authoring tool was
      developed that allowed creation of patient-specific PGRs and the accompanying
      provider reports. These were converted to a format that allowed them to be
      presented in the patient portal and EHR respectively using the existing COMPASSTM
      interface thus allowing patients, caregivers and providers access to individual
      reports designed for the intended end user. CONCLUSIONS: The PGR as developed was
      shown to enhance patient and provider communication around genomic results. It is
      built on current standards but is designed to support integration with other
      tools and be compatible with emerging opportunities such as SMART on FHIR. This
      approach could be used to support genomic return of results as the tool is
      scalable and generalizable.

PMID- 29843697
TI  - Life-history responses of insects to water-deficit stress: a case study with the
      aphid Sitobion avenae.
AB  - BACKGROUND: Drought may become one of the greatest challenges for cereal
      production under future warming scenarios, and its impact on insect pest
      outbreaks is still controversial. To address this issue, life-history responses
      of the English grain aphid, Sitobion avenae (Fabricius), from three areas of
      different drought levels were compared under three water treatments. RESULTS:
      Significant differences were identified in developmental time, fecundity and
      adult weight among S. avenae clones from moist, semiarid and arid areas under all
      the three water treatments. Semiarid and arid area clones tended to have higher
      heritability for test life-history traits than moist area clones. We identified
      significant selection of water-deficit on the developmental time of 1st instar
      nymphs and adult weight for both semiarid and arid area clones. The impact of
      intermediate and severe water-stress on S. avenae's fitness was neutral and
      negative (e.g., decreased fecundity and weight), respectively. Compared with arid
      area clones, moist- and semiarid-area clones showed higher extents of adaptation
      to the water-deficit level of their respective source environment. Adult weight
      was identified as a good indicator for S. avenae's adaptation potential under
      different water-stress conditions. After their exposure to intermediate water
      deficit stress for only five generations, adult weight and fecundity tended to
      decrease for moist- and semiarid-area clones, but increase for arid-area clones.
      CONCLUSIONS: It is evident from our study that S. avenae clones from moist,
      semiarid and arid areas have diverged under different water-deficit stress, and
      such divergence could have a genetic basis. The impact of drought on S. avenae's
      fitness showed a water-level dependent pattern. Clones of S. avenae were more
      likely to become adapted to intermediate water-deficit stress than severe water
      deficit stress. After continuous water-deficit stress of only five generations,
      the adaptation potential of S. avenae tended to decrease for moist and semiarid
      area clones, but increase for arid area clones. The rapid shift of aphids' life
      history traits and adaptation potential under drought could have significant
      implications for their evolutionary dynamics and outbreak risks in future climate
      change scenarios.

PMID- 29843698
TI  - Screening pregnant women for suicidal behavior in electronic medical records:
      diagnostic codes vs. clinical notes processed by natural language processing.
AB  - BACKGROUND: We examined the comparative performance of structured, diagnostic
      codes vs. natural language processing (NLP) of unstructured text for screening
      suicidal behavior among pregnant women in electronic medical records (EMRs).
      METHODS: Women aged 10-64 years with at least one diagnostic code related to
      pregnancy or delivery (N = 275,843) from Partners HealthCare were included as our
      "datamart." Diagnostic codes related to suicidal behavior were applied to the
      datamart to screen women for suicidal behavior. Among women without any
      diagnostic codes related to suicidal behavior (n = 273,410), 5880 women were
      randomly sampled, of whom 1120 had at least one mention of terms related to
      suicidal behavior in clinical notes. NLP was then used to process clinical notes
      for the 1120 women. Chart reviews were performed for subsamples of women.
      RESULTS: Using diagnostic codes, 196 pregnant women were screened positive for
      suicidal behavior, among whom 149 (76%) had confirmed suicidal behavior by chart
      review. Using NLP among those without diagnostic codes, 486 pregnant women were
      screened positive for suicidal behavior, among whom 146 (30%) had confirmed
      suicidal behavior by chart review. CONCLUSIONS: The use of NLP substantially
      improves the sensitivity of screening suicidal behavior in EMRs. However, the
      prevalence of confirmed suicidal behavior was lower among women who did not have
      diagnostic codes for suicidal behavior but screened positive by NLP. NLP should
      be used together with diagnostic codes for future EMR-based phenotyping studies
      for suicidal behavior.

PMID- 29843699
TI  - Differences in the determinants of health insurance enrolment among working-age
      adults in two regions in Ghana.
AB  - BACKGROUND: Ghana's National Health Insurance Scheme (NHIS) has achieved varying
      levels of enrolment within the regions with different rural-urban populations
      with associated income inequalities. This study sought to investigate the
      differences in the determinants of enrolment between the Greater Accra (GAR) and
      Western (WR) regions of Ghana to inform the NHIS reforms. METHOD: Data from 4214
      adults, 18 years and above from a household survey conducted in the two regions
      was analyzed. Bivariate analysis (t-test for continuous and Pearson chi-square
      for categorical) was performed to examine differences in respondents
      characteristics (socio-economic and insurance enrolment) between the two regions
      for the total, urban and rural samples. Logistic regression estimation was
      performed to establish differences in determinant of enrolment between the
      regions. RESULTS: Age, sex, educational level, marital status, health status and
      travel time to nearest health facility were identified as determinants of
      enrolment in both regions and among the rural and urban residents within the
      regions. Although the rich and richest in both regions are more likely to enroll
      than the poor and poorest, the odds of enrolment for the urban richest in the WR
      is about twice that of GAR whiles the odds of enrolment for the rural richest in
      the GAR is also about twice that of the WR. Those who visit public facilities in
      the GAR are more likely to enroll than those in WR for the total and urban
      samples. However, those who visit private facilities in rural communities in both
      regions are more likely to enroll. CONCLUSION: Differences in the NHIS enrolment
      between the regions is as a result of differences in socio-economic factors that
      are intrinsic in the regions and impact on the inhabitants' ability to afford
      insurance premium. Policymakers should determine NHIS premium differently at the
      district level based on socio-economic activities and income levels within the
      districts.

PMID- 29843700
TI  - Comparison of health-related quality of Life (HRQOL) among patients with pre
      diabetes, diabetes and normal glucose tolerance, using the 15D-HRQOL
      questionnaire in Greece: the DEPLAN study.
AB  - BACKGROUND: Diabetes mellitus is usually preceded by a pre-diabetic stage before
      the clinical presentation of the disease, the influence of which on persons'
      quality of life is not adequately elucidated. The purpose of this study was to
      compare the Health-Related Quality of Life (HRQOL) of persons with pre-diabetes
      with that of diabetes or normal glucose tolerance (NGT), using the validated
      HRQOL-15D questionnaire. METHODS: The HRQOL-15D scores of 172 people with pre
      diabetes (108 with Impaired Fasting Glucose [IFG], 64 with Impaired Glucose
      Tolerance [IGT], aged 58.3 +/- 10.3 years) and 198 with NGT (aged 54.4 +/- 10.1
      years) from the Greek part of the DEPLAN study (Diabetes in Europe - Prevention
      using Lifestyle, Physical Activity and Nutritional Intervention), were compared
      to 100 diabetes patients' scores (aged 60.9 +/- 12.5 years, diabetes duration
      17.0 +/- 10.0 years, HbA1c 7.2 +/- 1.2%), derived from the outpatient Diabetes
      Clinic of a University Hospital. RESULTS: The diabetes patients' HRQOL-15D score
      (0.8605) was significantly lower than the pre-diabetes' (0.9008) and the
      controls' (0.9092) (p < 0.001). There were no differences in the total score
      between the controls and the group with pre-diabetes. However, examination of
      individual parameters of the score showed that people with IGT had lower scores
      compared to the control group, as related to the parameters of "mobility" and
      "psychological distress". No differences were found in any component of the HRQOL
      15D score between the control group and the IFG group, nor between the two groups
      with pre-diabetes (IFG vs. IGT). CONCLUSIONS: Persons with pre-diabetes had a
      similar HRQOL score with healthy individuals, and a higher score than persons
      with diabetes. Specific components of the score, however, were lower in the IGT
      group compared to the controls. These findings help clarify the issue of HRQOL of
      persons with pre-diabetes and its possible impact on prevention.

PMID- 29843701
TI  - Comparison of solvate ionic liquids and DMSO as an in vivo delivery and storage
      media for small molecular therapeutics.
AB  - BACKGROUND: Solvate ionic liquids (SILs) are a new class of ionic liquids that
      are equimolar solutions of lithium bistrifluoromethanesulfonimide in either
      triglyme or tetraglyme, referred to as G3LiTFSA and G4LiTFSA, respectively. SILs
      play a role in energy storage lithium batteries, and have been proposed as
      potential alternatives to traditional organic solvents such as DMSO. G3TFSA and
      G4TFSA have been shown to exhibit no toxicity in vivo up to 0.5% (v/v), and
      solubilize small compounds (N,N-diethylaminobenzaldehyde) with full penetrance,
      similar to DMSO delivered DEAB. Herein, we compare the effects of storage (either
      at room temperature or - 20  degrees C) on DEAB solubilized in either DMSO,
      G3TFSA or G4TFSA to investigate compound degradation and efficacy. RESULTS: The
      findings show that DEAB stored at room temperature (RT) for 4 months solubilized
      in either G3TFSA, G4TFSA or DMSO displayed no loss of penetrance. The same was
      observed with stock solutions stored at - 20  degrees C for 4 months; however
      G4TFSA remained in a liquid state compared to both G3TFSA and DMSO. Moreover, we
      examined the ability of G3TFSA and G4TFSA to solubilize another small molecular
      therapeutic, the FGFR antagonist SU5402. G4TFSA, unlike G3TFSA solubilized SU5402
      and displayed similar phenotypic characteristics and reduced dlx2a expression as
      reported and shown with SU5402 in DMSO; albeit more penetrative. CONCLUSION: This
      study validates the use of these ionic liquids as a potential replacement for
      DMSO in vivo as organic solubilizing agents.

PMID- 29843702
TI  - Sustainability in Health care by Allocating Resources Effectively (SHARE) 11:
      reporting outcomes of an evidence-driven approach to disinvestment in a local
      healthcare setting.
AB  - BACKGROUND: This is the final paper in a thematic series reporting a program of
      Sustainability in Health care by Allocating Resources Effectively (SHARE) in a
      local healthcare setting. The SHARE Program was established to explore a
      systematic, integrated, evidence-based organisation-wide approach to
      disinvestment in a large Australian health service network. This paper summarises
      the findings, discusses the contribution of the SHARE Program to the body of
      knowledge and understanding of disinvestment in the local healthcare setting, and
      considers implications for policy, practice and research. DISCUSSION: The SHARE
      program was conducted in three phases. Phase One was undertaken to understand
      concepts and practices related to disinvestment and the implications for a local
      health service and, based on this information, to identify potential settings and
      methods for decision-making about disinvestment. The aim of Phase Two was to
      implement and evaluate the proposed methods to determine which were sustainable,
      effective and appropriate in a local health service. A review of the current
      literature incorporating the SHARE findings was conducted in Phase Three to
      contribute to the understanding of systematic approaches to disinvestment in the
      local healthcare context. SHARE differed from many other published examples of
      disinvestment in several ways: by seeking to identify and implement disinvestment
      opportunities within organisational infrastructure rather than as standalone
      projects; considering disinvestment in the context of all resource allocation
      decisions rather than in isolation; including allocation of non-monetary
      resources as well as financial decisions; and focusing on effective use of
      limited resources to optimise healthcare outcomes. CONCLUSION: The SHARE findings
      provide a rich source of new information about local health service decision
      making, in a level of detail not previously reported, to inform others in similar
      situations. Multiple innovations related to disinvestment were found to be
      acceptable and feasible in the local setting. Factors influencing decision
      making, implementation processes and final outcomes were identified; and methods
      for further exploration, or avoidance, in attempting disinvestment in this
      context are proposed based on these findings. The settings, frameworks, models,
      methods and tools arising from the SHARE findings have potential to enhance
      health care and patient outcomes.

PMID- 29843703
TI  - The degree of bother and healthcare seeking behaviour in women with symptoms of
      pelvic organ prolapse from a developing gulf country.
AB  - BACKGROUND: The healthcare-seeking behaviour of women with pelvic organ prolapse
      (POP) is affected by several factors including the cultural background. There is
      limited number of studies which addressed the healthcare-seeking behaviour in
      women with POP. The aim of this study was to determine the degree of bother,
      social impact and healthcare seeking behaviour of symptoms of POP in one of the
      Gulf countries and compare the results to published data from other areas.
      METHODS: All women who attended the three family development centres in our city
      between January 2010 and January 2011 and who had symptoms suggestive of POP were
      included in the study. The data was collected by well-trained interviewers.
      RESULTS: One hundred twenty-seven women reported symptoms of POP (mean age: 38.2
      years; range: 18-71). Out of these, 111 (87.4%) had at least one activity
      (physical, social or prayers) or sexual relationship affected by POP symptoms. In
      49 women (38%), the effect on at least one of these activities or relationships
      has been described as moderate and in 18 women (14%), the effect was severe.
      Sixty-nine women (54%) did not seek medical advice due to: embarrassment to see
      medical doctors (51%), the belief that POP is normal among women (51%), hope for
      spontaneous resolution (48%), embarrassment to see male doctors (33%) and
      unawareness of the existence of medical treatment (30%). On univariate analysis,
      the need to insert the finger in the vagina to empty the bladder or bowel and the
      interference of symptoms with physical activities, had significantly determined
      healthcare seeking attitude (P < 0.05 for all). However, on multivariate analysis
      interference with physical activities was the only significant determinant (P =
      0.04). CONCLUSIONS: Although POP had affected the quality of life in the majority
      of the affected women, unlike some other societies, more than half failed to seek
      healthcare advice mainly due to shyness and embarrassment and lack of proper
      knowledge about the condition. Interference of symptoms with physical activities
      was the main significant determinants of healthcare-seeking behaviour. Additional
      teaching campaigns designed according to cultural backgrounds in each society are
      required to address these sensitive issues.

PMID- 29843704
TI  - Clinical significance of three-dimensional skeleton-arterial model in the
      management of delayed reconstruction of acetabular fractures.
AB  - BACKGROUND: Delayed reconstruction of acetabular fractures remains a challenging
      task for orthopedists because of malunion, fracture line absorption, and scar
      formation. Accurate osteotomy, interfragmentary release, and proper adaptation of
      plates are keys to successful surgery. Prevention of superior gluteal artery
      (SGA) injury induced by cleaning of the osteotylus and reduction of the sciatic
      notch is also important. Therefore, sufficient preoperative planning is
      essential. However, traditional planning methods do not readily provide direct
      visual and tactile feedback to surgeons. Rapid prototyping (RP) models have
      provided new opportunities in the preoperative planning of delayed reconstruction
      of acetabular fractures. We hypothesized that a three-dimensional (3D) skeleton
      arterial model would improve both preoperative planning in the management of
      fractures and arteries and intraoperative assistance during delayed
      reconstruction of complex acetabular fractures. METHODS: Eight patients were
      enrolled in this study. Data on the skeleton and arteries were obtained from
      computed tomography and angiography scans and used to produce RP models.
      Preoperative surgical planning and intraoperative assistance were performed using
      these models as references. RESULTS: All 3D skeleton-arterial models were
      extremely accurate. Reduction and fixation were performed programmatically and
      smoothly, and management of the SGA was reliably executed according to a thorough
      preoperative plan. The mean surgical time and intraoperative blood loss were
      224.4 min and 1250 ml, respectively. Among the eight patients, four underwent
      anatomic reduction and five had excellent functional outcomes at the final follow
      up. No significant complications occurred. CONCLUSIONS: This 3D skeleton-arterial
      model is helpful for orthopedists in preoperative planning and intraoperative
      assistance.

PMID- 29843705
TI  - Application of a sub-specialties management model improves quality control in a
      central sterile supply department.
AB  - BACKGROUND: The management of medical devices is crucial to safe, high-quality
      surgical care, but has received little attention in the medical literature. This
      study explored the effect of a sub-specialties management model in the Central
      Sterile Supply Department (CSSD). METHODS: A traditional routine management model
      (control) was applied from September 2015 through April 2016, and a newly
      developed sub-specialties management model (observation) was applied from July
      2016 through February 2017. Health personnel from various clinical departments
      were randomly selected to participate as the control (n = 86) and observation (n
      = 90) groups, respectively. The groups were compared for rates of personnel
      satisfaction, complaints regarding device errors, and damage of medical devices.
      RESULTS: The satisfaction score of the observation group (95.8 +/- 1.2) was
      significantly higher than that of the control (90.2 +/- 2.3; P = 0.000). The rate
      of complaints of the observation group (3.3%) was significantly lower than that
      of the control (11.6%; P = 0.035). The quality control regarding recycle and
      packing was significantly higher during the observation period than the control
      period, which favorably influenced the scores for satisfaction. The rate of
      damage to specialist medical devices during the observation period (0.40%) was
      lower than during the control period (0.61%; P = 0.003). The theoretical
      knowledge and practical skills of the CSSD professionals improved after
      application of the sub-specialties management model. CONCLUSIONS: A management
      model that considers the requirements of specialist medical devices can improve
      quality control in the CSSD.

PMID- 29843706
TI  - The product of fasting plasma glucose and triglycerides improves risk prediction
      of type 2 diabetes in middle-aged Koreans.
AB  - BACKGROUND: Screening for risk of type 2 diabetes mellitus (T2DM) is an important
      public health issue. Previous studies report that fasting plasma glucose (FPG)
      and triglyceride (TG)-related indices, such as lipid accumulation product (LAP)
      and the product of fasting glucose and triglyceride (TyG index), are associated
      with incident T2DM. We aimed to evaluate whether FPG or TG-related indices can
      improve the predictive ability of a diabetes risk model for middle-aged Koreans.
      METHODS: 7708 Koreans aged 40-69 years without diabetes at baseline were eligible
      from the Korean Genome and Epidemiology Study. The overall cumulative incidence
      of T2DM was 21.1% (766 cases) in men and 19.6% (797 cases) in women. Therefore,
      the overall cumulative incidence of T2DM was 20.3% (1563 cases). Multiple
      logistic regression analysis was conducted to compare the odds ratios (ORs) for
      incident T2DM for each index. The area under the receiver operating
      characteristic curve (AROC), continuous net reclassification improvement (cNRI),
      and integrated discrimination improvement (IDI) were calculated when each measure
      was added to the basic risk model for diabetes. RESULTS: All the TG-related
      indices and FPG were more strongly associated with incident T2DM than WC in our
      study population. The adjusted ORs for the highest quartiles of WC, TG, FPG, LAP,
      and TyG index compared to the lowest, were 1.64 (95% CI, 1.13-2.38), 2.03 (1.59
      2.61), 3.85 (2.99-4.97), 2.47 (1.82-3.34), and 2.79 (2.16-3.60) in men, and 1.17
      (0.83-1.65), 2.42 (1.90-3.08), 2.15 (1.71-2.71), 2.44 (1.82-3.26), and 2.85 (2.22
      3.66) in women, respectively. The addition of TG-related parameters or FPG, but
      not WC, to the basic risk model for T2DM (including age, body mass index, family
      history of diabetes, hypertension, current smoking, current drinking, and regular
      exercise) significantly increased cNRI, IDI, and AROC in both sexes. CONCLUSIONS:
      Adding either TyG index or FPG into the basic risk model for T2DM increases its
      prediction and reclassification ability. Compared to FPG, TyG index was a more
      robust T2DM predictor in the stratified sex and fasting glucose level. Therefore,
      TyG index should be considered as a screening tool for identification of people
      at high risk for T2DM in practice.

PMID- 29843707
TI  - Collecting sexual assault history and forensic evidence from adult women in the
      emergency department: a retrospective study.
AB  - BACKGROUND: The objective of this retrospective study was to examine the
      discrepancy between information derived from written medical reports and the
      results of forensic DNA analyses on swabs collected from the victims in 122 cases
      of alleged sexual assault treated at the Emergency Department of Padua Hospital.
      The examination of discrepant results has proved useful to support a broader
      application of sexual assault management, particularly during the taking of case
      history. METHODS: The Laboratory of Forensic Genetics of Padua University have
      processed samples from 122 sexual assault cases over a period of 5 years.
      RESULTS: Of the 103 cases in which the victim reported a penetration and
      ejaculation, only 67 (55% of all the samples) correlated with positive feedback
      match from the laboratory. In 36 cases in which the patient reported penetration
      with ejaculation, no male DNA was found in the samples collected. Therefore,
      there was a total of 41 cases in which the patient's report were not supported by
      laboratory data. In the remaining ten cases, which had an ambiguous history, 3
      tested positively for the presence of male DNA. CONCLUSIONS: To avoid
      discrepancies between the medical reporting and reconstruction of sex crimes, it
      is crucial to deploy strategies which focus not only on the technical aspects of
      evidence collection, but also on how the victim's story is recorded; such efforts
      could lead to better management of sexual assault victims, and to a strengthened
      legal impact of forensic evidence and of crime reconstruction.

PMID- 29843708
TI  - Hindering the formation and promoting the dispersion of medical biofilms: non
      lethal effects of seagrass extracts.
AB  - BACKGROUND: Biofilms have great significance in healthcare-associated infections
      owing to their inherent tolerance and resistance to antimicrobial therapies. New
      approaches to prevent and treat unwanted biofilms are urgently required. To this
      end, three seagrass species (Enhalus acoroides, Halophila ovalis and Halodule
      pinifolia) collected in Vietnam and in India were investigated for their effects
      in mediating non-lethal interactions on sessile bacterial (Escherichia coli) and
      fungal (Candida albicans) cultures. The present study was focused on anti-biofilm
      activities of seagrass extracts, without killing cells. METHODS: Methanolic
      extracts were characterized, and major compounds were identified by MS/MS
      analysis. The antibiofilm properties of the seagrass extracts were tested at sub
      lethal concentrations by using microtiter plate adhesion assay. The performance
      of the most promising extract was further investigated in elegant bioreactors to
      reproduce mature biofilms both at the solid/liquid and the solid/air interfaces.
      Dispersion and bioluminescent assays were carried out to decipher the mode of
      action of the bioactive extract. RESULTS: It was shown that up to 100 ppm of
      crude extracts did not adversely affect microbial growth, nor do they act as a
      carbon and energy source for the selected microorganisms. Seagrass extracts
      appear to be more effective in deterring microbial adhesion on hydrophobic
      surfaces than on hydrophilic. The results revealed that non-lethal concentrations
      of E. acoroides leaf extract: i) reduce bacterial and fungal coverage by 60.9 and
      73.9%, respectively; ii) affect bacterial biofilm maturation and promote
      dispersion, up to 70%, in fungal biofilm; iii) increase luminescence in Vibrio
      harveyi by 25.8%. The characterization of methanolic extracts showed the unique
      profile of the E. acoroides leaf extract. CONCLUSIONS: E. acoroides leaf extract
      proved to be the most promising extract among those tested. Indeed, the selected
      non-lethal concentrations of E. acoroides leaf extract were found to exert an
      antibiofilm effect on C. albicans and E. coli biofilm in the first phase of
      biofilm genesis, opening up the possibility of developing preventive strategies
      to hinder the adhesion of microbial cells to surfaces. The leaf extract also
      affected the dispersion and maturation steps in C. albicans and E. coli
      respectively, suggesting an important role in cell signaling processes.

PMID- 29843709
TI  - Genetic diversity of Coxiella burnetii in domestic ruminants in central Italy.
AB  - BACKGROUND: As the epidemiology of human Q Fever generally reflects the spread of
      Coxiella burnetii in ruminant livestock, molecular characterization of strains is
      essential to prevent human outbreaks. In this study we report the genetic
      diversity of C. burnetii in central Italy accomplished by MST and MLVA-6 on
      biological samples from 20 goat, sheep and cow farms. RESULTS: Five MST and ten
      MLVA profiles emerged from the analysis establishing a part of C. burnetii strain
      world atlas. In particular, ST32 occurred on 12 farms (60%), prevalently in goat
      specimens, while ST12 (25%) was detected on 4 sheep and 1 goat samples. ST8 and a
      variant of this genotype were described on 2 different sheep farms, whereas ST55
      was observed on a goat farm. Five complete MLVA profiles different from any other
      published genotypes were described in this study in addition to 15 MLVA
      incomplete panels. Despite this, polymorphic markers Ms23, Ms24 and Ms33 enabled
      the identification of samples sharing the same MST profile. CONCLUSIONS:
      Integration of such data in international databases can be of further help in the
      attempt of building a global phylogeny and epidemiology of Q fever in animals,
      with a "One Health" perspective.

PMID- 29843710
TI  - Gene expression of the liver of vaccination-protected mice in response to early
      patent infections of Plasmodium chabaudi blood-stage malaria.
AB  - BACKGROUND: The role of the liver for survival of blood-stage malaria is only
      poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi,
      protective vaccination induces healing and, thus, survival of otherwise lethal
      infections. This model is appropriate to study the role of the liver in
      vaccination-induced survival of blood-stage malaria. METHODS: Female Balb/c mice
      were vaccinated with a non-infectious vaccine consisting of plasma membranes
      isolated in the form of erythrocyte ghosts from P. chabaudi-infected erythrocytes
      at week 3 and week 1 before infection with P. chabaudi blood-stage malaria. Gene
      expression microarrays and quantitative real-time PCR were used to investigate
      the response of the liver, in terms of expression of mRNA and long intergenic non
      coding (linc)RNA, to vaccination-induced healing infections and lethal P.
      chabaudi malaria at early patency on day 4 post infection, when parasitized
      erythrocytes begin to appear in peripheral blood. RESULTS: In vaccination-induced
      healing infections, 23 genes were identified to be induced in the liver by >
      tenfold at p < 0.01. More than one-third were genes known to be involved in
      erythropoiesis, such as Kel, Rhag, Ahsp, Ermap, Slc4a1, Cldn13 Gata1, and Gfi1b.
      Another group of > tenfold expressed genes include genes involved in natural
      cytotoxicity, such as those encoding killer cell lectin-like receptors Klrb1a,
      Klrc3, Klrd1, the natural cytotoxicity-triggering receptor 1 Ncr1, as well as the
      granzyme B encoding Gzmb. Additionally, a series of genes involved in the control
      of cell cycle and mitosis were identified: Ccnb1, Cdc25c, Ckap2l were expressed >
      tenfold only in vaccination-protected mice, and the expression of 22 genes was at
      least 100% higher in vaccination-protected mice than in non-vaccinated mice.
      Furthermore, distinct lincRNA species were changed by > threefold in livers of
      vaccination-protected mice, whereas lethal malaria induced different lincRNAs.
      CONCLUSION: The present data suggest that protective vaccination accelerates the
      malaria-induced occurrence of extramedullary erythropoiesis, generation of liver
      resident cytotoxic cells, and regeneration from malaria-induced injury in the
      liver at early patency, which may be critical for final survival of otherwise
      lethal blood-stage malaria of P. chabaudi.

PMID- 29843711
TI  - Operational assessment of point-of-care diagnostics in rural primary healthcare
      clinics of KwaZulu-Natal, South Africa: a cross-sectional survey.
AB  - BACKGROUND: The World Health Organization (WHO) called for new clinical
      diagnostic for settings with limited access to laboratory services. Access to
      diagnostic testing may not be uniform in rural settings, which may result in poor
      access to essential healthcare services. The aim of this study is to determine
      the availability, current usage, and need for point-of-care (POC) diagnostic
      tests among rural primary healthcare (PHC) clinics in South Africa's KwaZulu
      Natal (KZN) province. METHODS: We used the KZN's Department of Health (DoH)
      clinic classification to identify the 232 rural PHC clinics in KZN, South Africa.
      We then randomly sampled 100 of 232 rural PHC clinics. Selected health clinics
      were surveyed between April to August 2015 to obtain clinic-level data for health
      worker volume and to determine the accessibility, availability, usage and need
      for POC tests. Professional healthcare workers responsible for POC testing at
      each clinic were interviewed to assess the awareness of POC testing. Data were
      survey weighted and analysed using Stata 13. RESULTS: Among 100 rural clinics,
      the average number of patients seen per week was 2865 +/- 2231 (range 374
      11,731). The average number of POC tests available and in use was 6.3 (CI: 6.2
      6.5) out of a potential of 51 tests. The following POC tests were universally
      available in all rural clinics: urine total protein, urine leukocytes, urine
      nitrate, urine pregnancy, HIV antibody and blood glucose test. The average number
      of desired POC diagnostic tests reported by the clinical staff was estimated at
      15 (CI: 13-17) per clinic. The most requested POC tests reported were serum
      creatinine (37%), CD4 count (37%), cholesterol (32%), tuberculosis (31%), and HIV
      viral load (23%). CONCLUSION: Several POC tests are widely available and in use
      at rural PHC clinics in South Africa's KZN province. However, healthcare workers
      have requested additional POC tests to improve detection and management of
      priority disease conditions. TRIAL REGISTRATION: Clinical Trials.gov Identifier:
      NCT02692274.

PMID- 29843712
TI  - FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and
      inflammation.
AB  - BACKGROUND: High level of serum fibroblast growth factor 23 (FGF23) is implicated
      in the development and progression of diabetic nephropathy (DN), making it a
      crucial factor in the pathogenesis of DN. FGF23 is also tightly correlated with
      inflammation in the progression of DN. The aim of this study was to explore
      whether the C-terminal of FGF23 (FGF23C-tail), an antagonist that can block the
      FGF23 signaling pathway by competing with intact FGF23, could exhibit a
      therapeutic effect on DN. RESULTS: Biochemical data and histological examination
      showed that FGF23 C-tail administration ameliorated the functional and
      morphological abnormalities of db/db mice with DN without changing the levels of
      circulating FGF23 and phosphate. Evaluation of morphology and fibrosis by
      Masson's trichrome staining and IHC staining of fibronectin, PCR, and western
      blot analysis showed that FGF23C-tail prevents diabetes-induced fibrosis in db/db
      mice. Importantly, FGF23C-tail decreased the levels of inflammatory cytokines in
      serum and renal tissues. CONCLUSION: FGF23C-tail may improve diabetic nephropathy
      by decreasing inflammation and fibrosis in db/db mice, suggesting that blocking
      of FGF23 action remains an important therapeutic target for the prevention or
      attenuation of the progression of DN.

PMID- 29843713
TI  - Development of a high-throughput flexible quantitative suspension array assay for
      IgG against multiple Plasmodium falciparum antigens.
AB  - BACKGROUND: Antibody responses to Plasmodium falciparum play a critical role in
      disease control. Finding reliable IgG biomarkers of protection is complicated by
      a parasite proteome of over 5000 proteins, some with polymorphisms. Studies of
      anti-malarial naturally acquired and vaccine immunity would benefit from a
      standard high-throughput immunoassay to measure multiple antibodies. A multiplex
      quantitative suspension assay to measure antigen-specific IgGs was developed and
      its precision (reproducibility and repeatability), dynamic range, limits of
      detection and quantification, and non-specific binding to different P. falciparum
      proteins tested. A set of 288 human plasma samples from a malaria-endemic region
      were analysed twice by two different operators. Another set of samples from 9
      malaria-naive and 10 malaria-exposed individuals were repetitively assayed during
      22 consecutive days. Positive controls, negative controls, blanks and
      microspheres coated with bovine serum albumin were included in all assays.
      RESULTS: The multiplex quantitative suspension assay demonstrated low non
      specific signal and good estimates of precision and reproducibility between
      operators. The overall mean of non-specific binding measured in 288 plasma
      samples was 32.83 to +/- 44.81 median fluorescence intensity (MFI). Repeatability
      was 7.66% +/- 15.89 between triplicates for all antigens and samples, being lower
      in samples from malaria-exposed than malaria-naive individuals. No evidence of
      significantly different variance across days in MFI or arbitrary units (AU)/mL
      was found, assuming homogeneity of variance between days of analysis. Intra-class
      correlation coefficient between 22 days of analysis was 0.98 (0.97-0.98) for MFI
      units and 0.9 (0.87-0.93) for AU/mL. Reproducibility between operators for all
      samples and antigens had an overall adjusted correlation of 0.929 for MFI and
      0.836 for AU/mL. CONCLUSIONS: This high-throughput multiplex immunoassay is
      simple and highly reproducible. This represents an asset for malaria vaccine
      studies involving CSP-specific antibodies and selected antigens for sero
      epidemiological purposes. Measuring a multiplex antigen panel in a single
      reaction will help to assess not only vaccine immunogenicity but also potential
      malaria vaccine effects on naturally acquired immune responses. This will
      accelerate the identification of immune correlates of protection, down-selection
      of vaccine formulations, antigen discovery and guide second-generation vaccine
      design.

PMID- 29843715
TI  - Differences in physical environmental characteristics between adolescents' actual
      and shortest cycling routes: a study using a Google Street View-based audit.
AB  - BACKGROUND: The objective evaluation of the physical environmental
      characteristics (e.g. speed limit, cycling infrastructure) along adolescents'
      actual cycling routes remains understudied, although it may provide important
      insights into why adolescents prefer one cycling route over another. The present
      study aims to gain insight into the physical environmental characteristics
      determining the route choice of adolescent cyclists by comparing differences in
      physical environmental characteristics between their actual cycling routes and
      the shortest possible cycling routes. METHODS: Adolescents (n = 204; 46.5% boys;
      14.4 +/- 1.2 years) recruited at secondary schools in and around Ghent (city in
      Flanders, northern part of Belgium) were instructed to wear a Global Positioning
      System device in order to identify cycling trips. For all identified cycling
      trips, the shortest possible route that could have been taken was calculated.
      Actual cycling routes that were not the shortest possible cycling routes were
      divided into street segments. Segments were audited with a Google Street View
      based tool to assess physical environmental characteristics along actual and
      shortest cycling routes. RESULTS: Out of 160 actual cycling trips, 73.1% did not
      differ from the shortest possible cycling route. For actual cycling routes that
      were not the shortest cycling route, a speed limit of 30 km/h, roads having few
      buildings with windows on the street side and roads without cycle lane were more
      frequently present compared to the shortest possible cycling routes. A mixed land
      use, roads with commercial destinations, arterial roads, cycle lanes separated
      from traffic by white lines, small cycle lanes and cycle lanes covered by
      lighting were less frequently present along actual cycling routes compared to the
      shortest possible cycling routes. CONCLUSIONS: Results showed that distance
      mainly determines the route along which adolescents cycle. In addition,
      adolescents cycled more along residential streets (even if no cycle lane was
      present) and less along busy, arterial roads. Local authorities should provide
      shortcuts free from motorised traffic to meet adolescents' preference to cycle
      along the shortest route and to avoid cycling along arterial roads.

PMID- 29843714
TI  - Towards a Dynamic Interaction Network of Life to unify and expand the
      evolutionary theory.
AB  - The classic Darwinian theory and the Synthetic evolutionary theory and their
      linear models, while invaluable to study the origins and evolution of species,
      are not primarily designed to model the evolution of organisations, typically
      that of ecosystems, nor that of processes. How could evolutionary theory better
      explain the evolution of biological complexity and diversity? Inclusive network
      based analyses of dynamic systems could retrace interactions between (related or
      unrelated) components. This theoretical shift from a Tree of Life to a Dynamic
      Interaction Network of Life, which is supported by diverse molecular, cellular,
      microbiological, organismal, ecological and evolutionary studies, would further
      unify evolutionary biology.

PMID- 29843716
TI  - The VEGF and PEDF levels in the follicular fluid of patients co- treated with
      LETROZOLE and gonadotropins during the stimulation cycle.
AB  - BACKGROUND: Previous studies have shown that androgens, in addition to serving as
      precursors for ovarian estrogen synthesis, also have a fundamental role in
      primate ovarian follicular development by augmentation of FSH receptor expression
      on granulosa cells. Recent studies have shown that aromatase inhibitor,
      letrozole, improves ovarian response to FSH in normal and poor responder
      patients, possibly by increasing intraovarian androgen levels. Studies in mice
      also showed an effect of letrozole to increase pigment epithelium-derived factor
      (PEDF) and to lower vascular epithelial growth factor (VEGF), which might be
      expected to reduce the risk of ovarian hyperstimulation syndrome (OHSS) with
      stimulation. The aim of this study was to compare the VEGF and PEDF levels in the
      follicular fluids of normal responders treated with letrozole and gonadotropins
      during the ovarian stimulation with patients treated with gonadotropins only.
      METHODS: A single center, prospective clinical trial. We collected follicular
      fluid from 26 patients, on a GnRH antagonist protocol, dual triggered with hCG
      and GnRH agonist. The patients in one group were co-treated with letrozole and
      gonadotropins during the ovarian stimulation and the patients in the other group
      were treated with gonadotropins only. VEGF, PEDF, estrogen, progesterone and
      testosterone levels were measured by ELISA kits. RESULTS: The age of the
      patients, the total dose of gonadotropins and the number of oocytes were
      comparable between the two groups. In the follicular fluid, the estrogen levels
      (2209 nmol/l vs. 3280 nmol/l, p = 0.02) were significantly decreased, and the
      testosterone levels (246.5 nmol/l vs. 40.7 nmol/l, p < 0.001) were significantly
      increased in the letrozole group compared to the gonadotropin only group. The
      progesterone levels (21.4 MUmol/l vs. 17.5 p = NS) were comparable between the
      two groups. The VEGF levels (2992 pg/ml vs. 1812 pg/ml p = 0.02) were
      significantly increased and the PEDF levels (9.7 ng/ml vs 17.3 ng/ml p < 0.001)
      were significantly decreased in the letrozole group. CONCLUSIONS: Opposite to
      observations in the mouse, we found that VEGF levels were increased and PEDF
      levels were decreased in the follicular fluid in patients treated with letrozole
      during the stimulation cycles. Further investigation is required to determine if
      patients treated with letrozole during the IVF stimulation protocol are at
      increased risk for developing OHSS as a result of these findings.

PMID- 29843717
TI  - Monitoring health systems readiness and inpatient malaria case-management at
      Kenyan county hospitals.
AB  - BACKGROUND: Change of severe malaria treatment policy from quinine to artesunate,
      a major malaria control advance in Africa, is compromised by scarce data to
      monitor policy translation into practice. In Kenya, hospital surveys were
      implemented to monitor health systems readiness and inpatient malaria case
      management. METHODS: All 47 county referral hospitals were surveyed in February
      and October 2016. Data collection included hospital assessments, interviews with
      inpatient health workers and retrospective review of patients' admission files.
      Analysis included 185 and 182 health workers, and 1162 and 1224 patients admitted
      with suspected malaria, respectively, in all 47 hospitals. Cluster-adjusted
      comparisons of the performance indicators with exploratory stratifications were
      performed. RESULTS: Malaria microscopy was universal during both surveys.
      Artesunate availability increased (63.8-85.1%), while retrospective stock-outs
      declined (46.8-19.2%). No significant changes were observed in the coverage of
      artesunate trained (42.2% vs 40.7%) and supervised health workers (8.7% vs
      12.8%). The knowledge about treatment policy improved (73.5-85.7%; p = 0.002)
      while correct artesunate dosing knowledge increased for patients < 20 kg (42.7
      64.6%; p < 0.001) and > 20 kg (70.3-80.8%; p = 0.052). Most patients were tested
      on admission (88.6% vs 92.1%; p = 0.080) while repeated malaria testing was low
      (5.2% vs 8.1%; p = 0.034). Artesunate treatment for confirmed severe malaria
      patients significantly increased (69.9-78.7%; p = 0.030). No changes were
      observed in artemether-lumefantrine treatment for non-severe test positive
      patients (8.0% vs 8.8%; p = 0.796). Among test negative patients, increased
      adherence to test results was observed for non-severe (68.6-78.0%; p = 0.063) but
      not for severe patients (59.1-62.1%; p = 0.673). Overall quality of malaria case
      management improved (48.6-56.3%; p = 0.004), both for children (54.1-61.5%; p =
      0.019) and adults (43.0-51.0%; p = 0.041), and in both high (51.1-58.1%; p =
      0.024) and low malaria risk areas (47.5-56.0%; p = 0.029). CONCLUSION: Most
      health systems and malaria case-management indicators improved during 2016. Gaps,
      often specific to different inpatient populations and risk areas, however remain
      and further programmatic interventions including close monitoring is needed to
      optimize policy translation.

PMID- 29843718
TI  - Keys to the avian malaria parasites.
AB  - BACKGROUND: Malaria parasites (genus Plasmodium) are widespread in birds. These
      pathogens cause pathology of blood and various organs, often resulting in severe
      avian malaria. Numerous recent studies have reported DNA sequences of avian
      malaria parasites, indicating rich genetic diversity and the possible existence
      of many undescribed species. However, the majority of reported Plasmodium
      lineages remain unidentified to species level, and molecular characterization is
      unavailable for the majority of described Plasmodium parasites. During the past
      15 years, numerous new Plasmodium species have been described. However, keys for
      their identification are unavailable or incomplete. Identification of avian
      malaria parasites remains a difficult task even for experts, and this precludes
      development of avian malariology, particularly in wildlife. Here, keys for avian
      malaria parasites have been developed as a baseline for assisting academic and
      veterinary medicine researchers in identification of these pathogens. The main
      obstacles and future research priorities have been defined in the taxonomy of
      avian Plasmodium species. METHODS: The data were considered from published
      articles and type and voucher material, which was accessed in museums in Europe,
      the USA and Australia. Blood films containing various blood stages of the
      majority of described species were examined and used for the development of
      dichotomous keys for avian Plasmodium species. RESULTS: In all, 164 published
      articles were included in this review. Blood stages of avian Plasmodium parasites
      belonging to subgenera Haemamoeba, Giovannolaia, Novyella, Bennettinia and Huffia
      were analysed and compared. Illustrated keys for identification of subgenera and
      species of these parasites were developed. Lists of invalid and synonymous
      Plasmodium parasite names as well as names of doubtful identity were composed.
      CONCLUSION: This study shows that 55 described species of avian Plasmodium can be
      readily identified using morphological features of their blood stages. These were
      incorporated in the keys. Numerous synonymous names of Plasmodium species and
      also the names belonging to the category species inquirenda exist, and they can
      be used as reserves for future taxonomy studies. Molecular markers are
      unavailable for 58% of described Plasmodium parasites, raising a task for the
      current avian malaria researchers to fill up this gap.

PMID- 29843719
TI  - The Ramazzini Institute 13-week study on glyphosate-based herbicides at human
      equivalent dose in Sprague Dawley rats: study design and first in-life endpoints
      evaluation.
AB  - BACKGROUND: Glyphosate-based herbicides (GBHs) are the most widely used
      pesticides worldwide, and glyphosate is the active ingredient of such herbicides,
      including the formulation known as Roundup. The massive and increasing use of
      GBHs results in not only the global burden of occupational exposures, but also
      increased exposure to the general population. The current pilot study represents
      the first phase of a long-term investigation of GBHs that we are conducting over
      the next 5 years. In this paper, we present the study design, the first
      evaluation of in vivo parameters and the determination of glyphosate and its
      major metabolite aminomethylphosphonic acid (AMPA) in urine. METHODS: We exposed
      Sprague-Dawley (SD) rats orally via drinking water to a dose of glyphosate
      equivalent to the United States Acceptable Daily Intake (US ADI) of 1.75 mg/kg
      bw/day, defined as the chronic Reference Dose (cRfD) determined by the US EPA,
      starting from prenatal life, i.e. gestational day (GD) 6 of their mothers. One
      cohort was continuously dosed until sexual maturity (6-week cohort) and another
      cohort was continuously dosed until adulthood (13-week cohort). Here we present
      data on general toxicity and urinary concentrations of glyphosate and its major
      metabolite AMPA. RESULTS: Survival, body weight, food and water consumption of
      the animals were not affected by the treatment with either glyphosate or Roundup.
      The concentration of both glyphosate and AMPA detected in the urine of SD rats
      treated with glyphosate were comparable to that observed in animals treated with
      Roundup, with an increase in relation to the duration of treatment. The majority
      of glyphosate was excreted unchanged. Urinary levels of the parent compound,
      glyphosate, were around 100-fold higher than the level of its metabolite, AMPA.
      CONCLUSIONS: Glyphosate concentrations in urine showed that most part of the
      administered dose was excreted as unchanged parent compound upon glyphosate and
      Roundup exposure, with an increasing pattern of glyphosate excreted in urine in
      relation to the duration of treatment. The adjuvants and the other substances
      present in Roundup did not seem to exert a major effect on the absorption and
      excretion of glyphosate. Our results demonstrate that urinary glyphosate is a
      more relevant marker of exposure than AMPA in the rodent model.

PMID- 29843720
TI  - Soluble epoxide hydrolase inhibitors, t-AUCB, downregulated miR-133 in a mouse
      model of myocardial infarction.
AB  - BACKGROUND: It has been demonstrated that soluble epoxide hydrolase inhibitors
      (sEHIs) are protective against ischemia-induced lethal arrhythmias, but the
      mechanisms involved are unknown. Previously, we showed that sEHIs might reduce
      the incidence of ischemic arrhythmias by suppressing microRNA-1 (miR-1) in the
      myocardium. As miR-1 and miR-133 have the same proarrhythmic effects in the
      heart, we assumed that the beneficial effects of sEHIs might also relate to the
      regulation of miR-133. METHODS: A mouse model of myocardial infarction (MI) was
      established by ligating the coronary artery. The sEHI t-AUCB (trans-4-[4-(3
      adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid) was administered daily for 7
      days before MI. Myocardial infarct size and cardiac function was assessed at 24 h
      post-MI. The miRNA expression profiles of sham and MI mice treated with or
      without t-AUCB were determined by microarray and verified by real-time PCR. The
      incidence of arrhythmias was assessed by in vivo electrophysiologic studies. The
      mRNA levels of miR-133, its target genes (KCNQ1 [potassium voltage-gated channel
      subfamily Q member 1] and KCNH2 [potassium voltage-gated channel subfamily H
      member 2]), and serum response factor (SRF) were measured by real-time PCR;
      KCNQ1, KCNH2, and SRF protein levels were assessed by western blotting. RESULTS:
      We demonstrated that the treatment with sEHIs could reduce infarct size, improve
      cardia function, and prevent the development of cardiac arrhythmias in MI mice.
      The expression levels of 14 miRNAs differed between the sham and MI groups. t
      AUCB treatment altered the expression of eight miRNAs: two were upregulated and
      six were downregulated. Of these, the muscle-specific miR-133 was downregulated
      in the ischemic myocardium. In line with this, up-regulation of miR-133 and down
      regulation of KCNQ1 and KCNH2 mRNA/protein were observed in ischemic myocaridum,
      whereas administration of sEHIs produced an opposite effect. In addition, miR-133
      overexpression inhibited expression of the target mRNA, whereas t-AUCB reversed
      the effects. Furthermore, SRF might participate in the negative regulation of miR
      133 by t-AUCB. CONCLUSIONS: In MI mice, sEHI t-AUCB can repress miR-133,
      consequently stimulating KCNQ1 and KCNH2 mRNA and protein expression, suggesting
      a possible mechanism for its potential therapeutic application in ischemic
      arrhythmias.

PMID- 29843721
TI  - Comparison of visual and automated Deki Reader interpretation of malaria rapid
      diagnostic tests in rural Tanzanian military health facilities.
AB  - BACKGROUND: Although microscopy is a standard diagnostic tool for malaria and the
      gold standard, it is infrequently used because of unavailability of laboratory
      facilities and the absence of skilled readers in poor resource settings. Malaria
      rapid diagnostic tests (RDT) are currently used instead of or as an adjunct to
      microscopy. However, at very low parasitaemia (usually < 100 asexual
      parasites/ul), the test line on malaria rapid diagnostic tests can be faint and
      consequently hard to visualize and this may potentially affect the interpretation
      of the test results. Fio Corporation (Canada), developed an automated RDT reader
      named Deki ReaderTM for automatic analysis and interpretation of rapid diagnostic
      tests. This study aimed to compare visual assessment and automated Deki Reader
      evaluations to interpret malaria rapid diagnostic tests against microscopy.
      Unlike in the previous studies where expert laboratory technicians interpreted
      the test results visually and operated the device, in this study low cadre health
      care workers who have not attended any formal professional training in laboratory
      sciences were employed. METHODS: Finger prick blood from 1293 outpatients with
      fever was tested for malaria using RDT and Giemsa-stained microscopy for thick
      and thin blood smears. Blood samples for RDTs were processed according to
      manufacturers' instructions automated in the Deki Reader. Results of malaria
      diagnoses were compared between visual and the automated devise reading of RDT
      and microscopy. RESULTS: The sensitivity of malaria rapid diagnostic test results
      interpreted by the Deki Reader was 94.1% and that of visual interpretation was
      93.9%. The specificity of malaria rapid diagnostic test results was 71.8% and
      that of human interpretation was 72.0%. The positive predictive value of malaria
      RDT results by the Deki Reader and visual interpretation was 75.8 and 75.4%,
      respectively, while the negative predictive values were 92.8 and 92.4%,
      respectively. The accuracy of RDT as interpreted by DR and visually was 82.6 and
      82.1%, respectively. CONCLUSION: There was no significant difference in
      performance of RDTs interpreted by either automated DR or visually by unskilled
      health workers. However, despite the similarities in performance parameters, the
      device has proven useful because it provides stepwise guidance on processing RDT,
      data transfer and reporting.

PMID- 29843722
TI  - Light sheet theta microscopy for rapid high-resolution imaging of large
      biological samples.
AB  - BACKGROUND: Advances in tissue clearing and molecular labeling methods are
      enabling unprecedented optical access to large intact biological systems. These
      developments fuel the need for high-speed microscopy approaches to image large
      samples quantitatively and at high resolution. While light sheet microscopy
      (LSM), with its high planar imaging speed and low photo-bleaching, can be
      effective, scaling up to larger imaging volumes has been hindered by the use of
      orthogonal light sheet illumination. RESULTS: To address this fundamental
      limitation, we have developed light sheet theta microscopy (LSTM), which
      uniformly illuminates samples from the same side as the detection objective,
      thereby eliminating limits on lateral dimensions without sacrificing the imaging
      resolution, depth, and speed. We present a detailed characterization of LSTM, and
      demonstrate its complementary advantages over LSM for rapid high-resolution
      quantitative imaging of large intact samples with high uniform quality.
      CONCLUSIONS: The reported LSTM approach is a significant step for the rapid high
      resolution quantitative mapping of the structure and function of very large
      biological systems, such as a clarified thick coronal slab of human brain and
      uniformly expanded tissues, and also for rapid volumetric calcium imaging of
      highly motile animals, such as Hydra, undergoing non-isomorphic body shape
      changes.

PMID- 29843723
TI  - Measuring outcomes of community aged care programs: challenges, opportunities and
      the Australian Community Outcomes Measurement ACCOM tool.
AB  - Measuring health and wellbeing outcomes of community aged care programs is a
      complex task given the diverse settings in which care takes place and the
      intersection of numerous factors affecting an individual's quality of life
      outcomes. Knowledge of a strong causal relationship between services provided and
      the final outcome enables confidence in assuming the care provided was largely
      responsible for the outcome achieved (Courtney et al., Aust J Adv Nurs 26:49-57,
      2009). The Department of Health has recently reported on the findings of The
      National Aged Care Quality Indicator Program - Home Care Pilot (KPMG, National
      Aged Care Quality Indicator Program - Home Care Pilot, 2017). The Program sought
      to test various tools to measure quality of life outcomes of their community aged
      care programs. Some of the key issues raised in the study reiterate the findings
      from The Australian Community Care Outcome Measurement (ACCOM) pilot study
      (Cardona et al., Australas J Ageing 36: 69-71, 2017), including the value of the
      ASCOT SCT4 tool (Adult Social care Outcomes Toolkit,
      http://www.pssru.ac.uk/ascot/downloads/questionnaires/sct4.pdf ) to measure
      social care related quality of life (SCRQoL) in community aged care programs in
      the Australian context, the collection of additional data to map the relationship
      of various variables such as functional ability, demographic characteristics and
      quality of life scores and the governance and administration of measurement tools
      for the purpose of quality reporting and consumer choice.

PMID- 29843724
TI  - Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their
      extracellular vesicles in experimental silicosis.
AB  - BACKGROUND: Silicosis is an occupational disease that affects workers who inhale
      silica particles, leading to extensive lung fibrosis and ultimately causing
      respiratory failure. Mesenchymal stromal cells (MSCs) have been shown to exert
      therapeutic effects in lung diseases and represent an alternative treatment for
      silicosis. Recently, it has been suggested that similar effects can be achieved
      by the therapeutic use of extracellular vesicles (EVs) obtained from MSCs. The
      aim of this study was to investigate the effects of adipose-tissue-derived MSCs
      (AD-MSCs) or their EVs in a model of silicosis. METHODS: Silicosis was induced by
      intratracheal instillation of silica in C57BL/6 mice. After the onset of disease,
      animals received saline, AD-MSCs, or EVs, intratracheally. RESULTS: At day 30, AD
      MSCs and EVs led to a reduction in collagen fiber content, size of granuloma, and
      in the number of macrophages inside granuloma and in the alveolar septa. In
      addition, the expression levels of interleukin 1beta and transforming growth
      factor beta in the lungs were decreased. Higher dose of EVs also reduced lung
      static elastance when compared with the untreated silicosis group. CONCLUSIONS:
      Both AD-MSCs and EVs, locally delivered, ameliorated fibrosis and inflammation,
      but dose-enhanced EVs yielded better therapeutic outcomes in this model of
      silicosis.

PMID- 29843725
TI  - The Ramazzini Institute 13-week pilot study on glyphosate and Roundup
      administered at human-equivalent dose to Sprague Dawley rats: effects on the
      microbiome.
AB  - BACKGROUND: Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that
      act on the shikimate pathway in bacteria, fungi, and plants. The possible effects
      of GBHs on human health are the subject of an intense public debate for both its
      potential carcinogenic and non-carcinogenic effects, including its effects on
      microbiome. The present pilot study examines whether exposure to GBHs at doses of
      glyphosate considered to be "safe" (the US Acceptable Daily Intake - ADI - of
      1.75 mg/kg bw/day), starting from in utero, may modify the composition of gut
      microbiome in Sprague Dawley (SD) rats. METHODS: Glyphosate alone and Roundup, a
      commercial brand of GBHs, were administered in drinking water at doses comparable
      to the US glyphosate ADI (1.75 mg/kg bw/day) to F0 dams starting from the
      gestational day (GD) 6 up to postnatal day (PND) 125. Animal feces were collected
      at multiple time points from both F0 dams and F1 pups. The gut microbiota of 433
      fecal samples were profiled at V3-V4 region of 16S ribosomal RNA gene and further
      taxonomically assigned and assessed for diversity analysis. We tested the effect
      of exposure on overall microbiome diversity using PERMANOVA and on individual
      taxa by LEfSe analysis. RESULTS: Microbiome profiling revealed that low-dose
      exposure to Roundup and glyphosate resulted in significant and distinctive
      changes in overall bacterial composition in F1 pups only. Specifically, at PND31,
      corresponding to pre-pubertal age in humans, relative abundance for Bacteriodetes
      (Prevotella) was increased while the Firmicutes (Lactobacillus) was reduced in
      both Roundup and glyphosate exposed F1 pups compared to controls. CONCLUSIONS:
      This study provides initial evidence that exposures to commonly used GBHs, at
      doses considered safe, are capable of modifying the gut microbiota in early
      development, particularly before the onset of puberty. These findings warrant
      future studies on potential health effects of GBHs in early development such as
      childhood.

PMID- 29843726
TI  - Predicting health-related quality of life (EQ-5D-5 L) and capability wellbeing
      (ICECAP-A) in the context of opiate dependence using routine clinical outcome
      measures: CORE-OM, LDQ and TOP.
AB  - BACKGROUND: Economic evaluation normally requires information to be collected on
      outcome improvement using utility values. This is often not collected during the
      treatment of substance use disorders making cost-effectiveness evaluations of
      therapy difficult. One potential solution is the use of mapping to generate
      utility values from clinical measures. This study develops and evaluates mapping
      algorithms that could be used to predict the EuroQol-5D (EQ-5D-5 L) and the
      ICEpop CAPability measure for Adults (ICECAP-A) from the three commonly used
      clinical measures; the CORE-OM, the LDQ and the TOP measures. METHODS: Models
      were estimated using pilot trial data of heroin users in opiate substitution
      treatment. In the trial the EQ-5D-5 L, ICECAP-A, CORE-OM, LDQ and TOP were
      administered at baseline, three and twelve month time intervals. Mapping was
      conducted using estimation and validation datasets. The normal estimation
      dataset, which comprised of baseline sample data, used ordinary least squares
      (OLS) and tobit regression methods. Data from the baseline and three month time
      periods were combined to create a pooled estimation dataset. Cluster and mixed
      regression methods were used to map from this dataset. Predictive accuracy of the
      models was assessed using the root mean square error (RMSE) and the mean absolute
      error (MAE). Algorithms were validated using sample data from the follow-up time
      periods. RESULTS: Mapping algorithms can be used to predict the ICECAP-A and the
      EQ-5D-5 L in the context of opiate dependence. Although both measures can be
      predicted, the ICECAP-A was better predicted by the clinical measures. There were
      no advantages of pooling the data. There were 6 chosen mapping algorithms, which
      had MAE scores ranging from 0.100 to 0.138 and RMSE scores ranging from 0.134 to
      0.178. CONCLUSION: It is possible to predict the scores of the ICECAP-A and the
      EQ-5D-5 L with the use of mapping. In the context of opiate dependence, these
      algorithms provide the possibility of generating utility values from clinical
      measures and thus enabling economic evaluation of alternative therapy options.
      TRIAL REGISTRATION: ISRCTN22608399 . Date of registration: 27/04/2012. Date of
      first randomisation: 14/08/2012.

PMID- 29843727
TI  - Preferred and actual retirement age of oral and maxillofacial surgeons aged 55
      and older in the Netherlands: a longitudinal study from 2003 to 2016.
AB  - BACKGROUND: In workforce planning for oral and maxillofacial surgeons in the
      Netherlands, it is important to plan timely, as these dental specialists are
      required to earn both medical and dental degrees. An important factor to take
      into account in workforce planning is the outflow of the profession through
      retirement. In the workforce planning in the Netherlands, it was assumed that
      retirement plans are a predictor for the actual moment of retirement. The purpose
      of this study was to investigate this assumption. METHODS: A standardised survey
      to investigate the work activity and retirement plans of oral and maxillofacial
      surgeons was conducted seven times between 2003 and 2016. With some minor
      variations, in every edition, all oral and maxillofacial surgeons aged 55 years
      and older who did not indicate to be retired in an earlier edition were invited
      to participate. The data of all seven editions was analysed to investigate what
      factors influence the actual retirement age. For the analyses of the data, ANOVA
      and linear regression were employed. RESULTS: The response rate was at least 80%
      in all editions. For all editions combined, 185 surgeons were invited one or more
      times, of whom 170 responded at least once. Between 2003 and 2016, the mean
      preferred retirement age increased from 63.7 to 66.7. Two thirds of the
      respondents who participated in more than one edition had revised their preferred
      retirement age upwards. Regarding the difference between preferred and actual
      retirement age, 45% of the oral and maxillofacial surgeons retired at a higher
      age than originally preferred and another 14% was still working at the age the
      originally preferred to retire. Linear regression shows that preferred retirement
      age is associated with sex and the number of working hours and that actual
      retirement age is associated with preferred retirement age, earlier preference to
      decrease working hours and working in non-academic hospitals. CONCLUSION:
      Altogether, it seems that in this group the preferred retirement age has some
      predictive value, but the oral and maxillofacial surgeons tend to retire at a
      higher age than they originally preferred to.

PMID- 29843728
TI  - A home monitoring program including real-time wireless home spirometry in
      idiopathic pulmonary fibrosis: a pilot study on experiences and barriers.
AB  - In idiopathic pulmonary fibrosis (IPF), home monitoring experiences are limited,
      not yet real-time available nor implemented in daily care. We evaluated
      feasibility and potential barriers of a new home monitoring program with real
      time wireless home spirometry in IPF. Ten patients with IPF were asked to test
      this home monitoring program, including daily home spirometry, for four weeks.
      Measurements of home and hospital spirometry showed good agreement. All patients
      considered real-time wireless spirometry useful and highly feasible. Both
      patients and researchers suggested relatively easy solutions for the identified
      potential barriers regarding real-time home monitoring in IPF.

PMID- 29843729
TI  - The need for independent research on the health effects of glyphosate-based
      herbicides.
AB  - BACKGROUND: Glyphosate, formulated as Roundup, is the world's most widely used
      herbicide. Glyphosate is used extensively on genetically modified (GM) food crops
      designed to tolerate the herbicide, and global use is increasing rapidly. Two
      recent reviews of glyphosate's health hazards report conflicting results. An
      independent review by the International Agency for Research on Cancer (IARC)
      found that glyphosate is a "probable human carcinogen". A review by the European
      Food Safety Agency (EFSA) found no evidence of carcinogenic hazard. These
      differing findings have produced regulatory uncertainty. REGULATORY ACTIONS:
      Reflecting this regulatory uncertainty, the European Commission on November 27
      2017, extended authorization for glyphosate for another 5 years, while the
      European Parliament opposed this decision and issued a call that pesticide
      approvals be based on peer-reviewed studies by independent scientists rather than
      on the current system that relies on proprietary industry studies. RAMAZZINI
      INSTITUTE RESPONSE: The Ramazzini Institute has initiated a pilot study of
      glyphosate's health hazards that will be followed by an integrated experimental
      research project. This evaluation will be independent of industry support and
      entirely sponsored by worldwide crowdfunding. The aim of the Ramazzini Institute
      project is to explore comprehensively the effects of exposures to glyphosate
      based herbicides at current real-world levels on several toxicological endpoints,
      including carcinogenicity, long-term toxicity, neurotoxicity, endocrine
      disrupting effects, prenatal developmental toxicity, the microbiome and multi
      generational effects.

PMID- 29843730
TI  - The effect of inlet and outlet boundary conditions in image-based CFD modeling of
      aortic flow.
AB  - BACKGROUND: Computational modeling of cardiovascular flow is a growing and useful
      field, but such simulations usually require the researcher to guess the flow's
      inlet and outlet conditions since they are difficult and expensive to measure. It
      is critical to determine the amount of uncertainty introduced by these
      assumptions in order to evaluate the degree to which cardiovascular flow
      simulations are accurate. Our work begins to address this question by examining
      the sensitivity of flow to several different assumed velocity inlet and outlet
      conditions in a patient-specific aorta model. METHODS: We examined the
      differences between plug flow, parabolic flow, linear shear flows, skewed cubic
      flow profiles, and Womersley flow at the inlet. Only the shape of the inlet
      velocity profile was varied-all other parameters were identical among these
      simulations. Secondary flow in the form of a counter-rotating pair of vortices
      was also added to parabolic axial flow to study its effect on the solution. In
      addition, we examined the differences between two-element Windkessel, three
      element Windkessel and the outflow boundary conditions. In these simulations,
      only the outlet boundary condition was varied. RESULTS: The results show axial
      and in-plane velocities are considerably different close to the inlet for the
      cases with different inlet velocity profile shapes. However, the solutions are
      qualitatively similar beyond 1.75D, where D is the inlet diameter. This trend is
      also observed in other quantities such as pressure and wall shear stress.
      Normalized root-mean-square deviation, a measure of axial velocity magnitude
      differences between the different cases, generally decreases along the streamwise
      coordinate. The linear shear inlet velocity boundary condition and plug velocity
      boundary condition solution exhibit the highest time-averaged wall shear stress,
      approximately [Formula: see text] higher than the parabolic inlet velocity
      boundary condition. Upstream of 1D from the inlet, adding secondary flow has a
      significant impact on temporal wall shear stress distributions. This is
      especially observable during diastole, when integrated wall shear stress
      magnitude varies about [Formula: see text] between simulations with and without
      secondary flow. The results from the outlet boundary condition study show the
      Windkessel models differ from the outflow boundary condition by as much as
      [Formula: see text] in terms of time-averaged wall shear stress. Furthermore,
      normalized root-mean-square deviation of axial velocity magnitude, a measure of
      deviation between Windkessel and the outflow boundary condition, increases along
      the streamwise coordinate indicating larger variations near outlets. CONCLUSION:
      It was found that the selection of inlet velocity conditions significantly
      affects only the flow region close to the inlet of the aorta. Beyond two
      diameters distal to the inlet, differences in flow solution are small. Although
      additional studies must be performed to verify this result, the data suggest that
      it is important to use patient-specific inlet conditions primarily if the
      researcher is concerned with the details of the flow very close to the inlet.
      Similarly, the selection of outlet conditions significantly affects the flow in
      the vicinity of the outlets. Upstream of five diameters proximal to the outlet,
      deviations between the outlet boundary conditions examined are insignificant.
      Although the inlet and outlet conditions only affect the flow significantly in
      their respective neighborhoods, our study indicates that outlet conditions
      influence a larger percentage of the solution domain.

PMID- 29843731
TI  - Tyrphostin AG17 inhibits adipocyte differentiation in vivo and in vitro.
AB  - BACKGROUND: Excessive subcutaneous adiposity in obesity is associated to positive
      white adipocyte tissue (WAT) differentiation (adipogenesis) and WAT
      expandability. Here, we hypothesized that supplementation with the insulin
      inhibitor and mitochondrial uncoupler, Tyrphostin (T-AG17), in vitro and in vivo
      inhibits adipogenesis and adipocyte hypertrophy. METHODS: We used a 3T3-L1
      proadipocyte cell line to identify the potential effect of T-AG17 on adipocyte
      differentiation and fat accumulation in vitro. We evaluated the safety of T-AG17
      and its effects on physiological and molecular metabolic parameters including
      hormonal profile, glucose levels, adipogenesis and adipocyte hypertrophy in a
      diet-induced obesity model using C57BL/6 mice. RESULTS: We found that T-AG17 is
      effective in preventing adipogenesis and lipid synthesis in the 3T3-L1 cell line,
      as evidenced by a significant decrease in oil red staining (p < 0.05). In obese
      C57BL/6 mice, oral administration of T-AG17 (0.175 mg/kg for 2 weeks) lead to
      decreased fat accumulation and WAT hypertrophy. Further, T-AG17 induced adipocyte
      apoptosis by activating caspase-3. In the hepatocytes of obese mice, T-AG17
      promoted an increase in the size of lipid inclusions, which was accompanied by
      glycogen accumulation. T-AG17 did not alter serum biochemistry, including
      glucose, insulin, leptin, free fatty acids, creatinine, and aspartate
      aminotransferase. CONCLUSION: T-AG17 promotes adipocyte apoptosis in vivo and is
      an effective modulator of adipocyte differentiation and WAT hypertrophy in vitro
      and in vivo. Therefore, T-AG17 may be useful as a pharmacological obesity
      treatment.

PMID- 29843732
TI  - Measuring the efficiency of Palestinian public hospitals during 2010-2015: an
      application of a two-stage DEA method.
AB  - BACKGROUND: While health needs and expenditure in the Occupied Palestinian
      Territories (OPT) are growing, the international donations are declining and the
      economic situation is worsening. The purpose of this paper is twofold, to
      evaluate the productive efficiency of public hospitals in West Bank and to study
      contextual factors contributing to efficiency differences. METHODS: This study
      examined technical efficiency among 11 public hospitals in West Bank from 2010
      through 2015 targeting a total of 66 observations. Nationally representative data
      were extracted from the official annual health reports. We applied input-oriented
      Data Envelopment Analysis (DEA) models to estimate efficiency scores. To
      elaborate further on performance, we used Tobit regression to identify contextual
      factors whose impact on inefficient performance is statistically significant.
      RESULTS: Despite the increase in efficiency mean scores by 4% from 2010 to 2015,
      findings show potential savings of 14.5% of resource consumption without reducing
      the volume of the provided services. The significant Tobit model showed four
      predictors explaining the inefficient performance of a hospital (p <  0.01) are:
      bed occupancy rate (BOR); the outpatient-inpatient ratio (OPIPR); hospital's size
      (SIZE); and the availability of primary healthcare centers within the hospital's
      catchment area (PRC). There is a strong effect of OPIPR on efficiency differences
      between hospitals: A one unit increase in OPIPR will lead a decrease of 19.7% in
      the predicted inefficiency level holding all other factors constant. CONCLUSION:
      To date, no previous studies have examined the efficiency of public hospitals in
      the OPT. Our work identified their efficiency levels for potential improvements
      and the determinants of efficient performance. Based on the measurement of
      efficiency, the generated information may guide hospitals' managers,
      policymakers, and international donors improving the performance of the main
      national healthcare provider. The scope of this study is limited to public
      hospitals in West Bank. For a better understanding of the Palestinian market,
      further research on private hospitals and hospitals in Gaza Strip will be useful.

PMID- 29843733
TI  - Development of pooled testing system for porcine epidemic diarrhoea using real
      time fluorescent reverse-transcription loop-mediated isothermal amplification
      assay.
AB  - BACKGROUND: Porcine epidemic diarrhoea (PED) is an emerging disease in pigs that
      causes massive economic losses in the swine industry, with high mortality in
      suckling piglets. Early identification of PED virus (PEDV)-infected herd through
      surveillance or monitoring strategies is necessary for mass control of PED.
      However, a common working diagnosis system involves identifying PEDV-infected
      animals individually, which is a costly and time-consuming approach. Given the
      above information, the thrusts of this study were to develop a real-time
      fluorescent reverse transcription loop-mediated isothermal amplification (RtF-RT
      LAMP) assay and establish a pooled testing system using faecal sample to identify
      PEDV-infected herd. RESULTS: In this study, we developed an accurate, rapid, cost
      effective, and simple RtF- RT-LAMP assay for detecting the PEDV genome targeting
      M gene. The pooled testing system using the RtF-RT-LAMP assay was optimized such
      that a pool of at least 15 individual faecal samples could be analysed.
      CONCLUSIONS: The developed RtF-RT-LAMP assay in our study could support the
      design and implementation of large-scaled epidemiological surveys as well as
      active surveillance and monitoring programs for effective control of PED.

PMID- 29843734
TI  - An innovative diagnostic technology for the codon mutation C580Y in kelch13 of
      Plasmodium falciparum with MinION nanopore sequencer.
AB  - BACKGROUND: The recent spread of artemisinin (ART)-resistant Plasmodium
      falciparum represents an emerging global threat to public health. In Southeast
      Asia, the C580Y mutation of kelch13 (k13) is the dominant mutation of ART
      resistant P. falciparum. Therefore, a simple method for the detection of C580Y
      mutation is urgently needed to enable widespread routine surveillance in the
      field. The aim of this study is to develop a new diagnostic procedure for the
      C580Y mutation using loop-mediated isothermal amplification (LAMP) combined with
      the MinION nanopore sequencer. RESULTS: A LAMP assay for the k13 gene of P.
      falciparum to detect the C580Y mutation was successfully developed. The detection
      limit of this procedure was 10 copies of the reference plasmid harboring the k13
      gene within 60 min. Thereafter, amplicon sequencing of the LAMP products using
      the MinION nanopore sequencer was performed to clarify the nucleotide sequences
      of the gene. The C580Y mutation was identified based on the sequence data
      collected from MinION reads 30 min after the start of sequencing. Further,
      clinical evaluation of the LAMP assay in 34 human blood samples collected from
      patients with P. falciparum malaria in Indonesia revealed a positive detection
      rate of 100%. All LAMP amplicons of up to 12 specimens were simultaneously
      sequenced using MinION. The results of sequencing were consistent with those of
      the conventional PCR and Sanger sequencing protocol. All procedures from DNA
      extraction to variant calling were completed within 3 h. The C580Y mutation was
      not found among these 34 P. falciparum isolates in Indonesia. CONCLUSIONS: An
      innovative method combining LAMP and MinION will enable simple, rapid, and high
      sensitivity detection of the C580Y mutation of P. falciparum, even in resource
      limited situations in developing countries.

PMID- 29843736
TI  - Automatic liver segmentation in computed tomography using general-purpose shape
      modeling methods.
AB  - BACKGROUND: Liver segmentation in computed tomography is required in many
      clinical applications. The segmentation methods used can be classified according
      to a number of criteria. One important criterion for method selection is the
      shape representation of the segmented organ. The aim of the work is automatic
      liver segmentation using general purpose shape modeling methods. METHODS: As part
      of the research, methods based on shape information at various levels of
      advancement were used. The single atlas based segmentation method was used as the
      simplest shape-based method. This method is derived from a single atlas using the
      deformable free-form deformation of the control point curves. Subsequently, the
      classic and modified Active Shape Model (ASM) was used, using medium body shape
      models. As the most advanced and main method generalized statistical shape
      models, Gaussian Process Morphable Models was used, which are based on multi
      dimensional Gaussian distributions of the shape deformation field. RESULTS:
      Mutual information and sum os square distance were used as similarity measures.
      The poorest results were obtained for the single atlas method. For the ASM method
      in 10 analyzed cases for seven test images, the Dice coefficient was above
      55[Formula: see text], of which for three of them the coefficient was over
      70[Formula: see text], which placed the method in second place. The best results
      were obtained for the method of generalized statistical distribution of the
      deformation field. The DICE coefficient for this method was 88.5[Formula: see
      text] CONCLUSIONS: This value of 88.5 [Formula: see text] Dice coefficient can be
      explained by the use of general-purpose shape modeling methods with a large
      variance of the shape of the modeled object-the liver and limitations on the size
      of our training data set, which was limited to 10 cases. The obtained results in
      presented fully automatic method are comparable with dedicated methods for liver
      segmentation. In addition, the deforamtion features of the model can be modeled
      mathematically by using various kernel functions, which allows to segment the
      liver on a comparable level using a smaller learning set.

PMID- 29843735
TI  - Collaborative and partnership research for improvement of health and social
      services: researcher's experiences from 20 projects.
AB  - BACKGROUND: Getting research into policy and practice in healthcare is a
      recognised, world-wide concern. As an attempt to bridge the gap between research
      and practice, research funders are requesting more interdisciplinary and
      collaborative research, while actual experiences of such processes have been less
      studied. Accordingly, the purpose of this study was to gain more knowledge on the
      interdisciplinary, collaborative and partnership research process by
      investigating researchers' experiences of and approaches to the process, based on
      their participation in an inventive national research programme. The programme
      aimed to boost collaborative and partnership research and build learning
      structures, while improving ways to lead, manage and develop practices in Swedish
      health and social services. METHODS: Interviews conducted with project leaders
      and/or lead researchers and documentation from 20 projects were analysed using
      directed and conventional content analysis. RESULTS: Collaborative approaches
      were achieved by design, e.g. action research, or by involving practitioners from
      several levels of the healthcare system in various parts of the research process.
      The use of dual roles as researcher/clinician or practitioner/PhD student or the
      use of education designed especially for practitioners or 'student researchers'
      were other approaches. The collaborative process constituted the area for the
      main lessons learned as well as the main problems. Difficulties concerned
      handling complexity and conflicts between different expectations and demands in
      the practitioner's and researcher's contexts, and dealing with human resource
      issues and group interactions when forming collaborative and interdisciplinary
      research teams. The handling of such challenges required time, resources,
      knowledge, interactive learning and skilled project management. CONCLUSIONS:
      Collaborative approaches are important in the study of complex phenomena. Results
      from this study show that allocated time, arenas for interactions and skills in
      project management and communication are needed during research collaboration to
      ensure support and build trust and understanding with involved practitioners at
      several levels in the healthcare system. For researchers, dealing with this
      complexity takes time and energy from the scientific process. For practitioners,
      this puts demands on understanding a research process and how it fits with on
      going organisational agendas and activities and allocating time. Some of the
      identified factors may be overlooked by funders and involved stakeholders when
      designing, performing and evaluating interdisciplinary, collaborative and
      partnership research.

PMID- 29843737
TI  - The advantages and limitations of guideline adaptation frameworks.
AB  - BACKGROUND: The implementation of evidence-based guidelines can improve clinical
      and public health outcomes by helping health professionals practice in the most
      effective manner, as well as assisting policy-makers in designing optimal
      programs. Adaptation of a guideline to suit the context in which it is intended
      to be applied can be a key step in the implementation process. Without taking the
      local context into account, certain interventions recommended in evidence-based
      guidelines may be infeasible under local conditions. Guideline adaptation
      frameworks provide a systematic way of approaching adaptation, and their use may
      increase transparency, methodological rigor, and the quality of the adapted
      guideline. This paper presents a number of adaptation frameworks that are
      currently available. We aim to compare the advantages and limitations of their
      processes, methods, and resource implications. These insights into adaptation
      frameworks can inform the future development of guidelines and systematic methods
      to optimize their adaptation. ANALYSIS: Recent adaptation frameworks show an
      evolution from adapting entire existing guidelines, to adapting specific
      recommendations extracted from an existing guideline, to constructing evidence
      tables for each recommendation that needs to be adapted. This is a move towards
      more recommendation-focused, context-specific processes and considerations. There
      are still many gaps in knowledge about guideline adaptation. Most of the
      frameworks reviewed lack any evaluation of the adaptation process and outcomes,
      including user satisfaction and resources expended. The validity, usability, and
      health impact of guidelines developed via an adaptation process have not been
      studied. Lastly, adaptation frameworks have not been evaluated for use in low
      income countries. CONCLUSION: Despite the limitations in frameworks, a more
      systematic approach to adaptation based on a framework is valuable, as it helps
      to ensure that the recommendations stay true to the evidence while taking local
      needs into account. The utilization of frameworks in the guideline implementation
      process can be optimized by increasing the understanding and upfront estimation
      of resource and time needed, capacity building in adaptation methods, and
      increasing the adaptability of the source recommendation document.

PMID- 29843738
TI  - Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive
      microgliosis prior to nigral degeneration.
AB  - After publication of the original article [1] it was noted that the name of
      author, D. Luke Fisher, was erroneously typeset in both the PDF and online
      formats of the manuscript as Luke D. Fisher.

PMID- 29843739
TI  - Reconstruction of a genome-scale metabolic model for Actinobacillus succinogenes
      130Z.
AB  - BACKGROUND: Actinobacillus succinogenes is a promising bacterial catalyst for the
      bioproduction of succinic acid from low-cost raw materials. In this work, a
      genome-scale metabolic model was reconstructed and used to assess the metabolic
      capabilities of this microorganism under producing conditions. RESULTS: The
      model, iBP722, was reconstructed based on the functional reannotation of the
      complete genome sequence of A. succinogenes 130Z and manual inspection of
      metabolic pathways, covering 1072 enzymatic reactions associated with 722
      metabolic genes that involve 713 metabolites. The highly curated model was
      effective in capturing the growth of A. succinogenes on various carbon sources,
      as well as the SA production under various growth conditions with fair agreement
      between experimental and predicted data. Calculated flux distributions under
      different conditions show that a number of metabolic pathways are affected by the
      activity of some metabolic enzymes at key nodes in metabolism, including the
      transport mechanism of carbon sources and the ability to fix carbon dioxide.
      CONCLUSIONS: The established genome-scale metabolic model can be used for model
      driven strain design and medium alteration to improve succinic acid yields.

PMID- 29843740
TI  - Standardizing an approach to the evaluation of implementation science proposals.
AB  - BACKGROUND: The fields of implementation and improvement sciences have
      experienced rapid growth in recent years. However, research that seeks to inform
      health care change may have difficulty translating core components of
      implementation and improvement sciences within the traditional paradigms used to
      evaluate efficacy and effectiveness research. A review of implementation and
      improvement sciences grant proposals within an academic medical center using a
      traditional National Institutes of Health framework highlighted the need for
      tools that could assist investigators and reviewers in describing and evaluating
      proposed implementation and improvement sciences research. METHODS: We
      operationalized existing recommendations for writing implementation science
      proposals as the ImplemeNtation and Improvement Science Proposals Evaluation
      CriTeria (INSPECT) scoring system. The resulting system was applied to pilot
      grants submitted to a call for implementation and improvement science proposals
      at an academic medical center. We evaluated the reliability of the INSPECT system
      using Krippendorff's alpha coefficients and explored the utility of the INSPECT
      system to characterize common deficiencies in implementation research proposals.
      RESULTS: We scored 30 research proposals using the INSPECT system. Proposals
      received a median cumulative score of 7 out of a possible score of 30. Across
      individual elements of INSPECT, proposals scored highest for criteria rating
      evidence of a care or quality gap. Proposals generally performed poorly on all
      other criteria. Most proposals received scores of 0 for criteria identifying an
      evidence-based practice or treatment (50%), conceptual model and theoretical
      justification (70%), setting's readiness to adopt new services/treatment/programs
      (54%), implementation strategy/process (67%), and measurement and analysis (70%).
      Inter-coder reliability testing showed excellent reliability (Krippendorff's
      alpha coefficient 0.88) for the application of the scoring system overall and
      demonstrated reliability scores ranging from 0.77 to 0.99 for individual
      elements. CONCLUSIONS: The INSPECT scoring system presents a new scoring criteria
      with a high degree of inter-rater reliability and utility for evaluating the
      quality of implementation and improvement sciences grant proposals.

PMID- 29843741
TI  - Distinct mutations with different inheritance mode caused similar retinal
      dystrophies in one family: a demonstration of the importance of genetic
      annotations in complicated pedigrees.
AB  - BACKGROUND: Retinitis pigmentosa (RP) is the most common form of inherited
      retinal dystrophy presenting remarkable genetic heterogeneity. Genetic
      annotations would help with better clinical assessments and benefit gene therapy,
      and therefore should be recommended for RP patients. This report reveals the
      disease causing mutations in two RP pedigrees with confusing inheritance patterns
      using whole exome sequencing (WES). METHODS: Twenty-five participants including
      eight patients from two families were recruited and received comprehensive
      ophthalmic evaluations. WES was applied for mutation identification.
      Bioinformatics annotations, intrafamilial co-segregation tests, and in silico
      analyses were subsequently conducted for mutation verification. RESULTS: All
      patients were clinically diagnosed with RP. The first family included two
      siblings born to parents with consanguineous marriage; however, no potential
      pathogenic variant was found shared by both patients. Further analysis revealed
      that the female patient carried a recurrent homozygous C8ORF37 p.W185*, while the
      male patient had hemizygous OFD1 p.T120A. The second family was found to
      segregate mutations in two genes, TULP1 and RP1. Two patients born to
      consanguineous marriage carried homozygous TULP1 p.R419W, while a recurrent
      heterozygous RP1 p.L762Yfs*17 was found in another four patients presenting an
      autosomal dominant inheritance pattern. Crystal structural analysis further
      indicated that the substitution from arginine to tryptophan at the highly
      conserved residue 419 of TULP1 could lead to the elimination of two hydrogen
      bonds between residue 419 and residues V488 and S534. All four genes, including
      C8ORF37, OFD1, TULP1 and RP1, have been previously implicated in RP etiology.
      CONCLUSIONS: Our study demonstrates the coexistence of diverse inheritance modes
      and mutations affecting distinct disease causing genes in two RP families with
      consanguineous marriage. Our data provide novel insights into assessments of
      complicated pedigrees, reinforce the genetic complexity of RP, and highlight the
      need for extensive molecular evaluations in such challenging families with
      diverse inheritance modes and mutations.

PMID- 29843742
TI  - C-reactive protein, glucose and iron concentrations are significantly altered in
      dogs undergoing open ovariohysterectomy or ovariectomy.
AB  - BACKGROUND: There are relatively few studies about the canine surgical stress
      response, a sequence of events orchestrated by the body in response to a surgical
      trauma which is sometimes, as shown in human surgery, deleterious to the patient.
      There is a need to identify objective markers to quantify this response in order
      to estimate tissue trauma and use the markers as potential early indicators of
      surgical complications. The study objective was to investigate the surgical
      stress response, measured by C-reactive protein (CRP), glucose and iron serum
      concentrations, to gonadectomy in female dogs, and to compare the response to
      ovariohysterectomy (OHE) with the response to ovariectomy (OVE). A randomized
      clinical trial was performed on a sample of 42 female dogs, which were divided
      into two groups: one group underwent OHE, the other OVE. RESULTS: Blood samples
      were collected immediately before surgery (T0), and at 1 (T1), 6 (T6), and 24
      (T24) h after surgery, and serum frozen and stored at - 80  degrees C for later
      analysis. Upon thawing, the serum samples were subjected to measurement of CRP,
      glucose and iron concentration. Seventeen dogs in the OHE group and 19 dogs in
      the OVE group were included in the statistical analysis. There was a significant
      increase in glucose concentration at all time points compared with T0, and an
      increase of CRP at T6 and T24. Iron concentration was significantly decreased at
      T6 and T24. Differences between the two groups could not be detected for any of
      the three variables. CONCLUSIONS: The study showed that both OHE and OVE induce a
      moderate surgical stress response in female dogs, measured by CRP, glucose and
      iron. A difference between the surgical techniques could not be detected for any
      of the variables, and hence; with regards to the parameters studied
      recommendations of one procedure over the other cannot be made and preferred
      technique remains the surgeon's choice.

PMID- 29843743
TI  - The GRADE Evidence to Decision (EtD) framework for health system and public
      health decisions.
AB  - OBJECTIVE: To describe a framework for people making and using evidence-informed
      health system and public health recommendations and decisions. BACKGROUND: We
      developed the GRADE Evidence to Decision (EtD) framework for health system and
      public health decisions as part of the DECIDE project, in which we simultaneously
      developed frameworks for these and other types of healthcare decisions, including
      clinical recommendations, coverage decisions and decisions about diagnostic
      tests. DEVELOPING THE FRAMEWORK: Building on GRADE EtD tables, we used an
      iterative approach, including brainstorming, consultation of the literature and
      with stakeholders, and an international survey of policy-makers. We applied the
      framework to diverse examples, conducted workshops and user testing with health
      system and public health guideline developers and policy-makers, and observed and
      tested its use in real-life guideline panels. FINDINGS: All the GRADE EtD
      frameworks share the same basic structure, including sections for formulating the
      question, making an assessment and drawing conclusions. Criteria listed in the
      assessment section of the health system and public health framework cover the
      important factors for making these types of decisions; in addition to the effects
      and economic impact of an option, the priority of the problem, the impact of the
      option on equity, and its acceptability and feasibility are important
      considerations that can inform both whether and how to implement an option.
      Because health system and public health interventions are often complex, detailed
      implementation considerations should be made when making a decision. The
      certainty of the evidence is often low or very low, but decision-makers must
      still act. Monitoring and evaluation are therefore often important considerations
      for these types of decisions. We illustrate the different components of the EtD
      framework for health system and public health decisions by presenting their
      application in a framework adapted from a real-life guideline. DISCUSSION: This
      framework provides a structured and transparent approach to support policy-making
      informed by the best available research evidence, while making the basis for
      decisions accessible to those whom they will affect. The health system and public
      health EtD framework can also be used to facilitate dissemination of
      recommendations and enable decision-makers to adopt, and adapt, recommendations
      or decisions.

PMID- 29843744
TI  - "Freshman's week": characteristics associated with participation and experiencing
      adverse effects.
AB  - BACKGROUND: "Freshman's week" (FW) is a Norwegian initiation ritual to higher
      education. Previous research has suggested that FW-participation is associated
      with better social adjustment to the student setting, as well as heavy alcohol
      use both during and after the event. In this study, we aimed to identify
      characteristics associated with participation in FW and characteristics
      associated with experiencing adverse effects of alcohol use during FW. METHODS:
      Students in the city of Bergen, Norway participated in a survey during fall 2015,
      shortly after FW. The current sample consisted of the first-year students (N = 4,
      401, estimated response rate: 49%). The sample's mean age was 24 years (range: 17
      73 years), 65% were females, and the majority were born in Norway (93%). Logistic
      regressions were conducted to identify characteristics associated with
      participation in FW and experiencing adverse effects. RESULTS: A total of 64% of
      the first-year students reported participation in FW, and 27% of these reported
      experiencing at least one adverse alcohol-related effect during FW. Participation
      in FW was positively associated with being single (OR = 1.29), extroversion (OR =
      1.18), and alcohol use (OR = 1.28), and inversely associated with age (OR =
      0.70), and having children (OR = 0.36). Several characteristics (e.g., alcohol
      use (OR = 1.84), extroversion (OR = 0.60), symptoms of depression (OR = 1.60))
      were associated with an increased risk of experiencing adverse effects of alcohol
      use during participation. CONCLUSION: The current results suggest that
      initiatives for increasing the participation rate in FW, reducing alcohol use
      during FW, and decreasing the occurrence of adverse alcohol effects during FW are
      warranted. Aiming to reduce the focus on alcohol use during FW, and seeking to
      make FW more available and enjoyable for students with other priorities, students
      who do not match the stereotype of the typical first-year student, and less
      sociable students, might both increase participation rate and prevent the
      occurrence of adverse alcohol effects. Future studies should aim to develop and
      assess interventions designed to increase participation in FW and reduce the
      occurrence of adverse effects related to participation.

PMID- 29843745
TI  - Novel splice site IDUA gene mutation in Tunisian pedigrees with hurler syndrome.
AB  - BACKGROUND: The mucopolysaccharidosis type I (MPS I) is a lysosomal storage
      disease resulting from the defective activity of the enzyme alpha-L-iduronidase
      (IDUA). The disease has three major clinical subtypes (severe Hurler syndrome,
      intermediate Hurler-Scheie syndrome and attenuated Scheie syndrome). We aim to
      identify the genetic variants in MPS I patients and to investigate the effect of
      the novel splice site mutation on splicing of IDUA- mRNA variability using
      bioinformatics tools. METHODS: The IDUA mutations were determined in four MPS I
      patients from four families from Northern Tunisia, by amplifying and sequencing
      each of the IDUA exons and intron-exon junctions. RESULTS: One novel splice site
      IDUA mutation, c.1650 + 1G > T in intron 11 and two previously reported
      mutations, p.A75T and p.R555H, were detected. The patients in families 1 and 2
      who have the Hurler phenotype were homozygotes for the novel splice site mutation
      c.1650 + 1G > T. The patient in family 3, who also had the Hurler phenotype, was
      a compound heterozygote for the novel splice site mutation c.1650 + 1G > T and
      for the previously reported missense mutation p.A75T. The patient in family 4 who
      had the Hurler-Scheie phenotype was a compound heterozygote for the novel splice
      site mutation c.1650 + 1G > T and for the previously reported missense mutation
      p.R555H. In addition, four known IDUA polymorphisms were identified.
      Bioinformatics tools allowed us to associate the variant c.1650 + 1G > T with the
      severe clinical phenotype of MPS I. This variant affects the essential nucleotide
      + 1 (G to T) of the donor splice site of IDUA intron 11. The G > T in intron 11
      leads to wild type donor site broken with minus 19.97% value compared to normal
      value with 0%, hence the new splice site acceptor has plus 5.59%. CONCLUSIONS:
      The present findings indicate that the identified mutations facilitate the
      accurate carrier detection (genetic counseling of at-risk relatives) and the
      molecular prenatal diagnosis in Tunisia.

PMID- 29843746
TI  - miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by
      targeting STAT3/Bcl2 signaling pathway.
AB  - BACKGROUND: Chemoresistance to temozolomide (TMZ) is a major challenge in the
      treatment of glioblastoma (GBM). We previously found that miR-519a functions as a
      tumor suppressor in glioma by targeting the signal transducer and activator of
      transcription 3 (STAT3)-mediated autophagy oncogenic pathway. Here, we
      investigated the effects of miR-519a on TMZ chemosensitivity and autophagy in GBM
      cells. Furthermore, the underlying molecular mechanisms and signaling pathways
      were explored. METHODS: In the present study, two stable TMZ-resistant GBM cell
      lines were successfully generated by exposure of parental cells to a gradually
      increasing TMZ concentration. After transfecting U87-MG/TMZ and U87-MG cells with
      miR-519a mimic or inhibitor, a series of biochemical assays such as MTT,
      apoptosis, and colony formation were performed to determine the chemosensitive
      response to TMZ. The autophagy levels in GBM cells were detected by transmission
      electron microscopy, LC3B protein immunofluorescence, and Western blotting
      analysis. Stable knockdown and overexpression of miR-519a in GBM cells were
      established using lentivirus. A xenograft nude mouse model and in situ brain
      model were used to examine the in vivo effects of miR-519a. Tumor tissue samples
      were collected from 48 patients with GBM and were used to assess the relationship
      between miR-519a and STAT3 expression. RESULTS: TMZ treatment significantly
      upregulated miR-519a in U87-MG cells but not in U87-MG/TMZ cells. Moreover, the
      expression of miR-519a and baseline autophagy levels was lower in U87-MG/TMZ
      cells as compared to U87-MG cells. miR-519a dramatically enhanced TMZ-induced
      autophagy and apoptotic cell death in U87-MG/TMZ cells, while inhibition of miR
      519a promoted TMZ resistance and reduced TMZ-induced autophagy in U87-MG cells.
      Furthermore, miR-519a induced autophagy through modification of STAT3 expression.
      The in vivo results showed that miR-519a can enhance apoptosis and sensitized GBM
      to TMZ treatment by promoting autophagy and targeting the STAT3/Bcl-2/Beclin-1
      pathway. In human GBM tissues, we found an inverse correlation between miR-519a
      and STAT3 expression. CONCLUSIONS: Our results suggested that miR-519a increased
      the sensitivity of GBM cells to TMZ therapy. The positive effects of miR-519a may
      be mediated through autophagy. In addition, miR-519a overexpression can induce
      autophagy by inhibiting STAT3/Bcl-2 pathway. Therefore, a combination of miR-519a
      and TMZ may represent an effective therapeutic strategy in GBM.

PMID- 29843747
TI  - A predictive score for optimal cytoreduction at interval debulking surgery in
      epithelial ovarian cancer: a two- centers experience.
AB  - BACKGROUND: Optimal cytoreduction (macroscopic Residual Tumor, RT = 0) is the
      best survival predictor factor in epithelial ovarian cancer (EOC). It doesn't
      exist a consolidated criteria to predict optimal surgical resection at interval
      debulking surgery (IDS). The aim of this study is to develop a predictive model
      of complete cytoreduction at IDS. METHODS: We, retrospectively, analyzed 93 out
      of 432 patients, with advanced EOC, underwent neoadjuvant chemotherapy (NACT) and
      IDS from January 2010 to December 2016 in two referral cancer centers. The
      correlation between clinical-pathological variables and residual disease at IDS
      has been investigated with univariate and multivariate analysis. A predictive
      score of cytoreduction (PSC) has been created by combining all significant
      variables. The performance of each single variable and PSC has been reported and
      the correlation of all significant variables with progression free survival (PFS)
      has been assessed. RESULTS: At IDS, 65 patients (69,8%) had complete
      cytoreduction with no residual disease (R = 0). Three criteria independently
      predicted R > 0: age >= 60 years (p = 0.014), CA-125 before NACT > 550 UI/dl (p =
      0.044), and Peritoneal Cancer Index (PCI) > 16 (p < 0.001). A PSC >= 3 has been
      associated with a better accuracy (85,8%), limiting the number of incomplete
      surgeries to 16,5%. Moreover, a PCI > 16, a PSC >= 3 and the presence of R > 0
      after IDS were all significantly associated with shorter PFS (p < 0.001, p <
      0.001 and p = 0.004 respectively). CONCLUSIONS: Our PSC predicts, in a large
      number of patients, complete cytoreduction at IDS, limiting the rate of futile
      extensive surgeries in case of presence of residual tumor (R > 0). The PSC should
      be prospectively validated in a larger series of EOC patients undergoing NACT
      IDS.

PMID- 29843748
TI  - Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an
      endemic osteochondropathy, Kashin-Beck disease.
AB  - BACKGROUND: Kashin-Beck disease (KBD) is an endemic, chronic, degenerative
      osteoarthropathy. KBD is usually diagnosed by using X-ray image and clinical
      symptoms, lacking of serological biomarkers. The serum level of PIICP, PIIANP,
      and PIIBNP can specifically reflect the damage of the cartilage. So, in this
      study, the serum levels of PIICP, PIIANP, and PIIBNP were detected in order to
      determine whether they can be used as potential biomarkers for the diagnosis of
      KBD. METHOD: Using a status survey, the survey sites were selected in the KBD
      historical endemic areas and non-endemic areas in Jilin and Heilongjiang
      provinces. All local residents have undergone clinical examination, X-ray
      examination of the hands and knees, and questionnaire survey. A total of 554
      people were surveyed, and 184 residents who are eligible for inclusion criteria
      were selected as our subjects. Fifty-six cases were diagnosed as KBD and 63
      individuals were included as internal control and 65 subjects were included as
      external control. And blood samples of surveyed subjects were collected, and the
      serum was separated to detect the levels of PIICP, PIIANP, and PIIBNP by ELISA.
      Statistical analysis was performed using the SPSS software. RESULTS: There were
      no statistically significant differences in age and sex among the three groups.
      The Kruskal-Wallis H test showed that the serum levels of PIICP, PIIANP, and
      PIIBNP were significantly different among the three groups. Multiple comparisons
      using Dunnett's T3 test revealed that serum levels of PIICP, PIIANP, and PIIBNP
      were significantly lower in KBD patients than in internal and external control.
      However, there was no significant difference between the internal and external
      control. CONCLUSIONS: The results preliminarily indicated that the levels of
      PIICP, PIIANP, and PIIBNP in serum could reflect the abnormal synthesis of type
      II collagen in KBD patients and suggested that these indicators might be used as
      potential biomarkers for the diagnosis of KBD.

PMID- 29843749
TI  - Hip pathology: the diagnostic accuracy of magnetic resonance imaging.
AB  - BACKGROUND: Hip arthroscopy has led to a greater understanding of intra-articular
      hip pathology. Non-contrast magnetic resonance imaging (MRI) is currently the
      gold standard in non-invasive imaging diagnosis, with high sensitivity in
      identifying labral pathology but equivocal results for ligamentum teres damage
      and chondral defects. The aim of this study is to determine the accuracy of non
      contrast MRI for diagnosis of intra-articular hip derangements and identify
      radiological features that could increase the accuracy of the diagnosis. METHODS:
      A prospective study of 71 hips on 68 patients undergoing hip arthroscopy was
      conducted comparing pre-operative analysis of MRI imaging versus an arthroscopic
      examination. Two musculoskeletal radiologists reported the data independently.
      All hip arthroscopies were performed by a single surgeon. Patients with MRIs
      performed within 6 months before hip arthroscopy were included. Outcome measures
      included observer accuracy identifying ligamentum teres tears, labral lesions,
      and chondral rim damage. Secondary outcome measures included inter-observer
      variability and correctly staged ligamentum teres tears. RESULTS: The accuracy of
      radiology reporting for ligamentum teres tears, labral damage, and chondral rim
      lesions was 85.92% for each instance. The MRI findings most consistent with
      labral tears include the presence of linear high signal traversing the articular
      surface into the labrum, presence of intra-labral fluid signal, and loss of
      homogenous low signal triangular morphology. Chondral rim damage was difficult to
      diagnose, but abnormal signal at the chondrolabral junction with partial
      thickness defects would suggest damage. Ligamentum teres tears are commonly found
      but poorly graded. Thickening and increased signal suggests synovitis while
      discontinuity and fraying suggests partial tearing. CONCLUSION: Conventional non
      arthrographic MRI offers an accurate non-invasive method to screen patients with
      symptoms referable to the hip by revealing the presence of labral tears, chondral
      defects, and ligamentum teres tears/synovitis. This study demonstrates that tears
      and synovitis of the ligamentum teres as potential sources of hip pain can be
      accurately identified on conventional non-arthrographic MRI. However, MRI has
      poor specificity and negative predictive value, and thus, a negative MRI result
      may warrant further investigation.

PMID- 29843750
TI  - Torque teno virus dynamics during the first year of life.
AB  - BACKGROUND: Torque teno virus is a small chronically persisting circular negative
      ssDNA virus reaching near 100% prevalence. It is reported to be a marker for
      immune function in immunocompromised patients. The possibility of vertical
      maternal-fetal transmission remains controversial but incidence rate of TTV DNA
      in children increased with age. TTV dynamics well studied for allogeneic
      hematopoietic stem cell transplantation as a predictor of post-transplant
      complications but there is no viral proliferation kinetics data for other patient
      groups or healthy individuals. The aim of this study was to determine TTV
      dynamics during the first year of life of healthy infants. METHODS: Ninety eight
      clinically healthy breastfeeding infants (1-12 months of age) were analyzed by
      quantitative PCR for the whole blood TTV load with the test sensitivity of about
      1000 viral copies per milliliter of blood (total number of samples including
      repeatedly tested infants was 109). RESULTS: 67% of all analyzed samples were TTV
      positive demonstrating significant positive correlation between age and TTV load
      (r = 0.81, p < 0.01). CONCLUSIONS: This is the first study to suggest that viral
      load increases during the first year of life reaching a plateau after 6 months
      with strong proliferation for the first 60 days. Our data well correlates with
      TTV dynamics in patients following allogeneic hematopoietic stem cell
      transplantation.

PMID- 29843751
TI  - Immediate reduction under general anesthesia and combined anterior and posterior
      fusion in the treatment of distraction-flexion injury in the lower cervical
      spine.
AB  - BACKGROUND: Distraction-flexion of the lower cervical spine is a severe traumatic
      lesion, frequently resulting in paralysis. The optimal surgical treatment is
      controversial. It has been a challenge for orthopedic surgeons to manage
      distraction-flexion injury in the lower cervical spine while avoiding the risk of
      iatrogenic damage. Thus, safer strategies need to be designed and adopted.This
      study aimed to evaluate the clinical efficacy of immediate reduction under
      general anesthesia and combined anterior and posterior fusion in the treatment of
      distraction-flexion injury in the lower cervical spine. METHODS: Twenty-four
      subjects of traumatic lower cervical spinal distraction-flexion were
      retrospectively analyzed from January 2010 to December 2013. Traffic accident was
      the primary cause of injury, with patients presenting with dislocated segments in
      C4-5 (n = 8), C5-6 (n = 10), and C6-7 (n = 6). Sixteen patients had unilateral
      facet dislocation and eight had bilateral facet dislocation. Spinal injuries were
      classified according to the American Spinal Injury Association (ASIA) impairment
      scale (2000 edition amended), with four cases of grade A, four cases of grade B,
      ten cases of grade C, four cases of grade D, and two cases of grade E. On
      admission, all patients underwent immediate reduction under general anesthesia
      and combined anterior and posterior fusion. The mean follow-up time was 3.5
      years. RESULTS: All operations were completed successfully, with no major
      complications. Postoperative X-rays showed satisfactory height for the cervical
      intervertebral space and recovery of the vertebral sequence. Bone fusion was
      completed within 4 to 6 months after surgery. Surgery also significantly improved
      neurological function in all patients. CONCLUSION: Immediate reduction under
      general anesthesia and combined anterior and posterior fusion can be used to
      successfully treat distraction-flexion injury in the lower cervical spine,
      obtaining completed decompression, safe spinal re-alignment, and excellent
      immediate postoperative stability.

PMID- 29843752
TI  - Stereotactic body radiation therapy (SBRT) in patients with hepatocellular
      carcinoma and oligometastatic liver disease.
AB  - BACKGROUND: To report our experience with SBRT in primary and secondary liver
      tumors. METHODS: We retrospectively analysed 55 patients (70 lesions) with a
      median follow-up of 10 months (range 1-57) treated from 2011 to 2016. All
      patients had not been eligible for other local treatment options. Median age was
      64 years and 64% were male. 27 patients (36 lesions) suffered from hepatocellular
      carcinoma (HCC, Child A:78%, Child B:18%, Child C:4%), 28 patients (34 lesions)
      had oligometastatic liver disease (MD). Treatment planning was based on 4D-CT
      usually after placement of fiducials. Dose and fractionation varied depending on
      localization and size, most commonly 3 * 12.5 Gy (prescribed to the surrounding
      65%-isodose) in 56% and 5x8Gy (80% isodose) in 20% of the treated lesions.
      RESULTS: Local recurrence was observed in 7 patients (13%) and 8 lesions (11%),
      resulting in estimated 1- and 2-year local control rates (LC) of 91 and 74%.
      Estimated 1- and 2-year rates of Freedom from hepatic failure (FFHF) were 42 and
      28%. Number of lesions was predictive for LC and FFHF in the entire cohort.
      Estimated 1- and 2-year overall survival (OS) was 76 and 57%. OS was
      significantly affected by number of treated lesions and performance status. In
      the HCC subgroup, pretreatment liver function and gender were also predictive for
      OS. Maximum acute non-hepatic toxicity was grade 1 in 16% and grade 2 in 10% of
      the patients. Three HCC patients (11%) developed marked deterioration of liver
      function (grade 3/4). CONCLUSIONS: SBRT resulted in high local control and
      acceptable survival rates in patients with HCC or MD not amendable to other
      locally-ablative treatment options with limited toxicity. Care should be taken in
      HCC patients with Child B cirrhosis.

PMID- 29843753
TI  - Mechanical CPR: Who? When? How?
AB  - In cardiac arrest, high quality cardiopulmonary resuscitation (CPR) is a key
      determinant of patient survival. However, delivery of effective chest
      compressions is often inconsistent, subject to fatigue and practically
      challenging.Mechanical CPR devices provide an automated way to deliver high
      quality CPR. However, large randomised controlled trials of the routine use of
      mechanical devices in the out-of-hospital setting have found no evidence of
      improved patient outcome in patients treated with mechanical CPR, compared with
      manual CPR. The limited data on use during in-hospital cardiac arrest provides
      preliminary data supporting use of mechanical devices, but this needs to be
      robustly tested in randomised controlled trials.In situations where high-quality
      manual chest compressions cannot be safely delivered, the use of a mechanical
      device may be a reasonable clinical approach. Examples of such situations include
      ambulance transportation, primary percutaneous coronary intervention, as a bridge
      to extracorporeal CPR and to facilitate uncontrolled organ donation after
      circulatory death.The precise time point during a cardiac arrest at which to
      deploy a mechanical device is uncertain, particularly in patients presenting in a
      shockable rhythm. The deployment process requires interruptions in chest
      compression, which may be harmful if the pause is prolonged. It is recommended
      that use of mechanical devices should occur only in systems where quality
      assurance mechanisms are in place to monitor and manage pauses associated with
      deployment.In summary, mechanical CPR devices may provide a useful adjunct to
      standard treatment in specific situations, but current evidence does not support
      their routine use.

PMID- 29843754
TI  - Immune checkpoint therapy in liver cancer.
AB  - Immune checkpoints include stimulatory and inhibitory checkpoint molecules. In
      recent years, inhibitory checkpoints, including cytotoxic T lymphocyte-associated
      antigen 4 (CTLA-4), programmed cell death protein-1 (PD-1), and programmed cell
      death ligand 1 (PD-L1), have been identified to suppress anti-tumor immune
      responses in solid tumors. Novel drugs targeting immune checkpoints have
      succeeded in cancer treatment. Specific PD-1 blockades were approved for
      treatment of melanoma in 2014 and for treatment of non-small-cell lung cancer in
      2015 in the United States, European Union, and Japan. Preclinical and clinical
      studies show immune checkpoint therapy provides survival benefit for greater
      numbers of patients with liver cancer, including hepatocellular carcinoma and
      cholangiocarcinoma, two main primary liver cancers. The combination of anti-PD
      1/PD-L1 with anti-CTLA-4 antibodies is being evaluated in phase 1, 2 or 3 trials,
      and the results suggest that an anti-PD-1 antibody combined with locoregional
      therapy or other molecular targeted agents is an effective treatment strategy for
      HCC. In addition, studies on activating co-stimulatory receptors to enhance anti
      tumor immune responses have increased our understanding regarding this
      immunotherapy in liver cancer. Epigenetic modulations of checkpoints for
      improving the tumor microenvironment also expand our knowledge of potential
      therapeutic targets in improving the tumor microenvironment and restoring immune
      recognition and immunogenicity. In this review, we summarize current knowledge
      and recent developments in immune checkpoint-based therapies for the treatment of
      hepatocellular carcinoma and cholangiocarcinoma and attempt to clarify the
      mechanisms underlying its effects.

PMID- 29843755
TI  - Randomized, phase I/II study of gemcitabine plus IGF-1R antagonist (MK-0646)
      versus gemcitabine plus erlotinib with and without MK-0646 for advanced
      pancreatic adenocarcinoma.
AB  - BACKGROUND: Binding of insulin-like growth factor-I (IGF-1) to its receptor (IGF
      1R) initiates downstream signals that activate PI3K/Akt/mTOR and MEK/Erk
      pathways, which stimulate cancer cell proliferation and induce drug resistance.
      Cross talk between IGF-1R and epidermal growth factor receptor (EGFR) mediates
      resistance to anti-EGFR agents. We studied safety, tolerability, and outcomes of
      MK-0646, IGF-1 monoclonal antibody, in combination with gemcitabine (G) +/-
      erlotinib (E) in metastatic pancreatic cancer. METHODS: Our study included a
      phase I dose escalation and phase II randomization and expansion cohorts. A 3 + 3
      dose escalation protocol was used to determine MK-0646 maximum tolerable dose
      (MTD) in combination with G +/- E standard doses. For phase II, patients were
      randomized to arm A (G + MK), arm B (G + MK + E), or arm C (G + E). Primary
      endpoint was progression-free survival (PFS). Secondary endpoints were overall
      survival (OS), disease control rate, toxicity, and correlation between OS and IGF
      1 in patients treated with MK-0646. RESULTS: MK-0646 MTD was 10 mg/kg in
      combination with G and 5 mg/kg in combination with G + E. In randomization
      cohort, 15 patients were treated in each arm. Disease control rates were 50, 60,
      and 40% respectively. PFS was not different between the three arms. OS was
      significantly different between arm A (10.4 months) and C (5.7 months) (P =
      0.02). However, addition of erlotinib in arm B yielded no OS benefit compared to
      arm A (P = 0.6). Plasma and tissue IGF-1 levels did not correlate with OS (P =
      0.64, 0.87). Grade 3-4 toxicity during phase II cohorts were neutropenia (10/arm
      A, 14/arm B, 5/arm C), leukopenia (5/A, 5/B, 7/C), thrombocytopenia (8/A, 9/B,
      2/C), hyponatremia (1/A, 3/B), and hyperglycemia (8/A, 1/B). CONCLUSIONS: MK-0646
      was tolerable in combination with G and associated with improvement in OS but not
      PFS as compared with G + E. Tissue and serum IGF-1 did not correlate with
      clinical outcome. TRIAL REGISTRATION: This trial is registered in
      ClinicalTrial.gov under the Identifier NCT00769483 and registration date was
      October 9, 2008.

PMID- 29843756
TI  - Clinical comparison of liquid-based and conventional cytology of oral brush
      biopsies: a randomized controlled trial.
AB  - BACKGROUND: Exfoliative cytology performed on oral brush samples can help
      dentists to decide, whether a given oral lesion is (pre-) malignant. The use of
      non-invasive brush biopsies as an auxiliary tool in the diagnosis of oral mucosal
      lesions has gained renewed interest since improvements in cytological techniques
      such as the development of adjuvant diagnostic tools and liquid-based cell
      preparation techniques. METHODS: The aim of this study was to compare the quality
      of two different preparation techniques (cell collectors): the conventional
      transfer procedure to glass slides and the so-called liquid-based cytology
      preparation method. Cell smears were collected from 10 orally healthy individuals
      (mean age: 24 years) from the palatine mucosa at two different times (baseline
      and 4 weeks later). Slides of both techniques were stained by Giemsa (n = 40) and
      May-Gruenwald Giemsa (n = 40). The statistical analysis was performed with Excel.
      RESULTS: On specimen analysis, the liquid-based cytology showed statistically
      significant improvement compared to conventional glass sides (p < 0.001). Thin
      layers, which were performed by liquid-based cytology showed significantly better
      results in the parameters (p < 0.001): uniform distribution, cellular
      overlapping, cellular disformation, mucus, microbial colonies and debris. The
      conventional glass slides approach showed more cell overlapping and contamination
      with extraneous material than thin layers, which were performed by Orcellex(r)
      Brush cell collectors. CONCLUSIONS: Both techniques are diagnostically reliable.
      The liquid-based method showed an overall improvement on sample preservation,
      specimen adequacy, visualization of cell morphology and reproducibility. Liquid
      based cytology simplifies cell collection due to easier handling and less
      transfer errors by dentists.

PMID- 29843757
TI  - Ch'ol nomenclature for soil classification in the ejido Oxolotan, Tacotalpa,
      Tabasco, Mexico.
AB  - BACKGROUND: The traditional ecological knowledge of land of the Ch'ol originary
      people from southeast Mexico forms part of their cultural identity; it is local
      and holistic and implies an integrated physical and spiritual worldview that
      contributes to improve their living conditions. We analyzed the nomenclature for
      soil classification used in the Mexican state of Tabasco by the Ch'ol farmers
      with the objective of contributing to the knowledge of the Maya soil
      classification. METHODS: A map of the study area was generated from the digital
      database of parcels in the ejido Oxolotan in the municipality of Tacotalpa, to
      which a geopedological map was overlaid in order to obtain modeled topographic
      profiles (Zavala-Cruz et al., Ecosistemas y Recursos Agropecuarios 3:161-171,
      2016). In each modeled profile, a soil profile was made and classified according
      to IUSS Working Group WRB (181, 2014) in order to generate a map of soil groups,
      which was used to survey the study area with the participation of 245 local Ch'ol
      farmers for establishing an ethnopedological soil classification (Ortiz et al.:
      62, 1990). In addition, we organized a participatory workshop with 35 people to
      know details of the names of the soils and their indicators of fertility and
      workability, from which we selected 15 participants for field trips and
      description of soil profiles. RESULTS: The color, texture, and stoniness are
      attributes important in the Ch'ol nomenclature, although the names do not
      completely reflect the visible characteristic of the soil surface. On the other
      hand, the mere presence of stones is sufficient to name a land class, while
      according to IUSS Working Group WRB (181, 2014), a certain amount and
      distribution of stones in the soil profiles is necessary to be taken into
      consideration in the name. Perception of soil quality by local farmers considers
      the compaction or hardness of the cultivable soil layer, because of which black
      or sandy soils are perceived as better for cultivation of banana, or as secondary
      vegetation in fallow. Red, yellow, or brown soils are seen as of less quality and
      are only used for establishing grasslands, while maize is cultivated in all soil
      classes. CONCLUSIONS: Farmers provided the Ch'ol nomenclature, perceived
      problems, and uses of each class of soil. Translation of Ch'ol soil names and
      comparison with descriptions of soil profiles revealed that the Ch'ol soil
      nomenclature takes into account the soil profile, given it is based on
      characteristics of both surface and subsurface horizons including color of soil
      matrix and mottles, stoniness, texture, and vegetation.

PMID- 29843758
TI  - Preoperative assessment of ovarian tumors using a modified multivariate index
      assay.
AB  - BACKGROUND: Preoperative differentiation between benign and malignant masses can
      be challenging. The aim of this research was to evaluate the performance of a
      modified multivariate index assay (MIA) in detecting ovarian cancer and to
      compare the effectiveness of gynecologist assessment, cancer antigen (CA) 125,
      and MIA for identifying ovarian masses with high suspicion of malignancy.
      RESULTS: This prospective observational study included 150 women with ovarian
      masses who underwent surgery in the Maternity Teaching Hospital from December
      2014 to May 2016. Preoperative estimation of modified MIA, assessment by a
      gynecologist, and CA 125 level correlated with the surgical histopathology. A
      modified MIA was implemented because of lack of access to the software typically
      used. Among 150 enrolled women there were 30 cases of malignancy, including 8
      cases (26%) of early-stage ovarian cancer and 22 cases (74%) of late-stage
      cancer. MIA showed high specificity (96.7%) in detecting cancer and a sensitivity
      of 70%, with a positive predictive value of 84% and a negative predictive value
      of 92.8%. No significant differences were detected between the MIA results and
      the histopathology results (P = 0.267). For early-stage ovarian cancer, the
      sensitivity of MIA was 100% compared with 75% for CA 125 alone. CONCLUSION: MIA
      seems to be effective for evaluation of ovarian tumors with higher specificity
      and positive predictive value than CA 125 while maintaining high negative
      predictive value and with only a slightly lower overall sensitivity. For
      evaluation of early-stage ovarian cancer, MIA showed a much higher sensitivity
      that markedly outperformed CA 125 alone. This modified MIA strategy may be
      particularly useful in low resource setting.

PMID- 29843759
TI  - Neuroinflammation is increased in the parietal cortex of atypical Alzheimer's
      disease.
AB  - BACKGROUND: While most patients with Alzheimer's disease (AD) present with memory
      complaints, 30% of patients with early disease onset present with non-amnestic
      symptoms. This atypical presentation is thought to be caused by a different
      spreading of neurofibrillary tangles (NFT) than originally proposed by Braak and
      Braak. Recent studies suggest a prominent role for neuroinflammation in the
      spreading of tau pathology. METHODS: We aimed to explore whether an atypical
      spreading of pathology in AD is associated with an atypical distribution of
      neuroinflammation. Typical and atypical AD cases were selected based on both NFT
      distribution and amnestic or non-amnestic clinical presentation.
      Immunohistochemistry was performed on the temporal pole and superior parietal
      lobe of 10 typical and 9 atypical AD cases. The presence of amyloid-beta (N
      terminal; IC16), pTau (AT8), reactive astrocytes (GFAP), microglia (Iba1, CD68,
      and HLA-DP/DQ/DR), and complement factors (C1q, C3d, C4b, and C5b-9) was
      quantified by image analysis. Differences in lobar distribution patterns of
      immunoreactivity were statistically assessed using a linear mixed model. RESULTS:
      We found a temporal dominant distribution for amyloid-beta, GFAP, and Iba1 in
      both typical and atypical AD. Distribution of pTau, CD68, HLA-DP/DQ/DR, C3d, and
      C4b differed between AD variants. Typical AD cases showed a temporal dominant
      distribution of these markers, whereas atypical AD cases showed a parietal
      dominant distribution. Interestingly, when quantifying for the number of amyloid
      beta plaques instead of stained surface area, atypical AD cases differed in
      distribution pattern from typical AD cases. Remarkably, plaque morphology and
      localization of neuroinflammation within the plaques was different between the
      two phenotypes. CONCLUSIONS: Our data show a different localization of
      neuroinflammatory markers and amyloid-beta plaques between AD phenotypes. In
      addition, these markers reflect the atypical distribution of tau pathology in
      atypical AD, suggesting that neuroinflammation might be a crucial link between
      amyloid-beta deposits, tau pathology, and clinical symptoms.

PMID- 29843760
TI  - Feasibility of optical coherence tomography angiography to assess changes in
      retinal microcirculation in ovine haemorrhagic shock.
AB  - BACKGROUND: This study aimed to investigate the feasibility of optical coherence
      tomography angiography (OCT-A) for quantitative analysis of flow density to
      assess changes in retinal perfusion in an experimental model of haemorrhagic
      shock. METHODS: Haemorrhagic shock was induced in five healthy, anaesthetized
      sheep by stepwise blood withdrawal of 3 * 10 ml?kg- 1 body weight. OCT-A imaging
      of retinal perfusion was performed using an OCT device. Incident dark-field
      illumination microscopy videos were obtained for the evaluation of conjunctival
      microcirculation. Haemodynamic variables and flow density data in the OCT
      angiogram were analysed before and during progressive haemorrhage resulting in
      haemorrhagic shock as well as after fluid resuscitation with 10 ml?kg- 1 body
      weight of balanced hydroxyethyl starch solution (6% HES 130/0.4). Videos of the
      conjunctival microcirculation were recorded at baseline, in haemorrhagic shock,
      and after resuscitation. Data are presented as median with interquartile range.
      Comparisons between time points were made using Friedman's test and the degree of
      correlation between two variables was expressed as Spearman's rank correlation
      coefficient. RESULTS: Mean arterial pressure and cardiac index (CI) decreased and
      lactate concentration increased after induction of shock, and haemodynamics
      recovered after resuscitation. The flow density in the superficial retinal OCT
      angiogram decreased significantly after shock induction (baseline 44.7% (40.3;
      50.5) vs haemorrhagic shock 34.5% (32.8; 40.4); P = 0.027) and recovered after
      fluid resuscitation (46.9% (41.7; 50.7) vs haemorrhagic shock; P = 0.027). The
      proportion of perfused vessels of the conjunctival microcirculation showed
      similar changes. The flow density measured using OCT-A correlated with the
      conjunctival microcirculation (perfused vessel density: Spearman's rank
      correlation coefficient rho = 0.750, P = 0.001) and haemodynamic parameters (CI:
      rho = 0.693, P < 0.001). CONCLUSIONS: Retinal flow density, measured using OCT-A,
      significantly decreased in shock and recovered after fluid therapy in an
      experimental model of haemorrhagic shock. OCT-A is feasible to assess changes in
      retinal perfusion in haemorrhagic shock and fluid resuscitation.

PMID- 29843761
TI  - Efficacy and safety of electro-acupuncture treatment in improving the
      consciousness of patients with traumatic brain injury: study protocol for a
      randomized controlled trial.
AB  - BACKGROUND: Traumatic brain injury (TBI) has become a leading cause of death
      among young people worldwide. Survivors may live with a long-term TBI-related
      disability or even develop a disorder of consciousness resulting in poor life
      quality and shortened life expectancy. Thus far, very few approaches have been
      found to be effective in the consciousness recovery of these patients.
      Acupuncture has long been used in the treatment of neurological disorders in
      China. However, its efficacy and safety in consciousness recovery remain to be
      proved. METHODS: Here, we present a study design and protocol of a randomized,
      blinded, controlled study to evaluate the efficacy and safety of electro
      acupuncture in the consciousness recovery of patients with TBI. A total of 150
      patients with initial Glasgow coma scale score of less than 8 points will be
      recruited in the trial and randomized into acupuncture or control groups.
      Patients in the control group will receive routine pharmacological treatment
      alone while patients in the acupuncture group will receive electro-acupuncture
      treatment for 10 days in addition to routine treatment. The efficacy will be
      assessed with the changes in Glasgow coma scale score and mismatch negativity of
      event-related brain potentials before and after treatment. Moreover, Glasgow
      outcome scale and Barthel index of activities of daily living will be compared
      between the two groups at 3 months after treatment. The secondary outcome
      measures are the length of stay in ICU and hospital, expenses in ICU and
      hospital, as well as the incidence of coma-related complications. The safety of
      electro-acupuncture will be assessed by monitoring the incidence of adverse
      events and changes in vital signs during the study. DISCUSSION: Results from this
      trial will significantly add to the current body of evidence on the role of
      electro-acupuncture in the consciousness recovery of patients with severe TBI. In
      addition, a more convenient and consistent electro-acupuncture method can be set
      up for clinical practice. If found to be effective and safe, electro-acupuncture
      will be a valuable complementary option for comatose patients with TBI. TRIAL
      REGISTRATION: Chinese Clinical Trial Registry: ChiCTR-INR-17011674 . Registered
      on 16 June 2016.

PMID- 29843762
TI  - Mechanisms of electrical vasoconstriction.
AB  - BACKGROUND: Electrical vasoconstriction is a promising approach to control blood
      pressure or restrict bleeding in non-compressible wounds. We explore the neural
      and non-neural pathways of electrical vasoconstriction in-vivo. METHODS: Charge
      balanced, asymmetric pulses were delivered through a pair of metal disc
      electrodes. Vasoconstriction was assessed by measuring the diameter of rat
      saphenous vessels stimulated with low-voltage (20 V, 1 ms) and high-voltage (150
      V, 10 MUs) stimuli at 10 Hz for 5 min. Activation pathways were explored by
      topical application of a specific neural agonist (phenylephrine, alpha-1
      receptor), a non-specific agonist (KCl) and neural inhibitors (phenoxybenzamine,
      25 mg/ml; guanethidine, 1 mg/ml). Acute tissue damage was assessed with a
      membrane permeability (live-dead) fluorescent assay. The Joule heating in tissue
      was estimated using COMSOL Multiphysics modeling. RESULTS: During stimulation,
      arteries constricted to 41 +/- 8% and 37 +/- 6% of their pre-stimulus diameter
      with low- and high-voltage stimuli, while veins constricted to 80 +/- 18% and 40
      +/- 11%, respectively. In arteries, despite similar extent of constriction, the
      recovery time was very different: about 30 s for low-voltage and 10 min for high
      voltage stimuli. Neural inhibitors significantly reduced low-voltage arterial
      constriction, but did not affect high-voltage arterial or venous constriction,
      indicating that high-voltage stimuli activate non-neural vasoconstriction
      pathways. Adrenergic pathways predominantly controlled low-voltage arterial but
      not venous constriction, which may involve a purinergic pathway. Viability
      staining confirmed that stimuli were below the electroporation threshold.
      Modeling indicates that heating of the blood vessels during stimulation (< 0.2 
      degrees C) is too low to cause vasoconstriction. CONCLUSIONS: We demonstrate that
      low-voltage stimuli induce reversible vasoconstriction through neural pathways,
      while high-voltage stimuli activate non-neural pathways, likely in addition to
      neural stimulation. Different stimuli providing precise control over the extent
      of arterial and venous constriction as well as relaxation rate could be used to
      control bleeding, perfusion or blood pressure.

PMID- 29843763
TI  - Trainer in a pocket - proof-of-concept of mobile, real-time, foot kinematics
      feedback for gait pattern normalization in individuals after stroke, incomplete
      spinal cord injury and elderly patients.
AB  - BACKGROUND: Walking disabilities negatively affect inclusion in society and
      quality of life and increase the risk for secondary complications. It has been
      shown that external feedback applied by therapists and/or robotic training
      devices enables individuals with gait abnormalities to consciously normalize
      their gait pattern. However, little is known about the effects of a technically
      assisted over ground feedback therapy. The aim of this study was to assess
      whether automatic real-time feedback provided by a shoe-mounted inertial-sensor
      based gait therapy system is feasible in individuals with gait impairments after
      incomplete spinal cord injury (iSCI), stroke and in the elderly. METHODS: In a
      non-controlled proof-of-concept study, feedback by tablet computer-generated
      verbalized instructions was given to individuals with iSCI, stroke and old age
      for normalization of an individually selected gait parameter (stride length,
      stance or swing duration, or foot-to-ground angle). The training phase consisted
      of 3 consecutive visits. Four weeks post training a follow-up visit was
      performed. Visits started with an initial gait analysis (iGA) without feedback,
      followed by 5 feedback training sessions of 2-3 min and a gait analysis at the
      end. A universal evaluation and FB scheme based on equidistant levels of
      deviations from the mean normal value (1 level = 1 standard deviation (SD) of the
      physiological reference for the feedback parameter) was used for assessment of
      gait quality as well as for automated adaptation of training difficulty. Overall
      changes in level over iGAs were detected using a Friedman's Test. Post-hoc
      testing was achieved with paired Wilcoxon Tests. The users' satisfaction was
      assessed by a customized questionnaire. RESULTS: Fifteen individuals with iSCI,
      11 after stroke and 15 elderly completed the training. The average level at iGA
      significantly decreased over the visits in all groups (Friedman's test, p <
      0.0001), with the biggest decrease between the first and second training visit
      (4.78 +/- 2.84 to 3.02 +/- 2.43, p < 0.0001, paired Wilcoxon test). Overall,
      users rated the system's usability and its therapeutic effect as positive.
      CONCLUSIONS: Mobile, real-time, verbalized feedback is feasible and results in a
      normalization of the feedback gait parameter. The results form a first basis for
      using real-time feedback in task-specific motor rehabilitation programs. TRIAL
      REGISTRATION: DRKS00011853 , retrospectively registered on 2017/03/23.

PMID- 29843764
TI  - Babesia vesperuginis in insectivorous bats from China.
AB  - BACKGROUND: To increase understanding of human bacterial and parasitic pathogens
      in bats, we investigated the prevalence of Babesia spp., Rickettsia spp.,
      Anaplasma spp. and Coxiella burnetii in bats from China. METHODS: Bats were
      captured from Mengyin County, Shandong Province of China using nets. DNA was
      extracted from the blood and spleen of bats for molecular detection of Babesia
      spp., Rickettsia spp., Anaplasma spp. and Coxiella burnetii with specific primers
      for each species. RESULTS: A total of 146 spleen samples and 107 blood samples of
      insectivorous bats, which belonged to 6 species within two families, were
      collected from Mengyin County, Shandong Province of China. We found that two
      Eptesicus serotinus (2/15, 13.3%) were positive for Babesia vesperuginis. We were
      unable to detect genomic sequences for Rickettsia spp., Anaplasma spp. and
      Coxiella burnetii. CONCLUSIONS: To our knowledge, our study showed for the first
      time the presence of Babesia vesperuginis in Eptesicus serotinus collected from
      China, suggesting that Babesia vesperuginis has a broad host species and
      geographical distribution.

PMID- 29843765
TI  - Clinical analysis of chemo-resistance risk factors in endometriosis associated
      ovarian cancer.
AB  - BACKGROUND: To analyze the clinical characteristics and chemo-resistance related
      factors of patients with resistant and non-resistant endometriosis-associated
      ovarian cancer (ovarian clear cell carcinoma and endometrioid carcinoma) by
      reviewing the data of epithelial ovarian cancer patients who received initial
      treatment in our hospital over a 12-year period. RESULTS: Among the 304 patients,
      17.1% were seen with platinum-based drug resistance. The ROC curve of continuous
      variables was drawn according to resistance situation, then they were grouped by
      age (< 48 or >= 48 years), tumor size (< 7 cm or >= 7 cm) and Ca125 (< 90 and >=
      90 U/ml). In univariate analysis, age >= 48 years, initial symptom of abdominal
      distension or weight loss, abnormal preoperative serum Ca125, Ca125 < 90 U/ml,
      advanced FIGO stage, absence of endometriosis, bilateral tumors, lack of
      lymphadenectomy, positive lymph nodes, unsatisfactory initial cytoreduction
      surgery and history of breast cancer were all related to drug resistance in
      ovarian cancer. In multivariate analysis, advanced stage, lack of
      lymphadenectomy, positive lymph nodes and history of breast cancer were
      independent risk factors related to platinum-based drug resistance (P < 0.05).
      CONCLUSION: For patients of endometriosis-related ovarian cancer, platinum-based
      drug resistance were associated with advanced FIGO stage, lack of
      lymphadenectomy, positive lymph nodes and history of breast cancer.

PMID- 29843766
TI  - Evaluation of the clinical effectiveness of bioactive glass (S53P4) in the
      treatment of non-unions of the tibia and femur: study protocol of a randomized
      controlled non-inferiority trial.
AB  - BACKGROUND: Treatment of non-union remains challenging and often necessitates
      augmentation of the resulting defect with an autologous bone graft (ABG). ABG is
      limited in quantity and its harvesting incurs an additional surgical intervention
      leaving the risk for associated complications and morbidities. Therefore,
      artificial bone graft substitutes that might replace autologous bone are needed.
      S53P4-type bioactive glass (BaG) is a promising material which might be used as
      bone graft substitute due to its osteostimulative, conductive and antimicrobial
      properties. In this study, we plan to examine the clinical effectiveness of BaG
      as a bone graft substitute in Masquelet therapy in comparison with present
      standard Masquelet therapy using an ABG with tricalciumphosphate to fill the bone
      defect. METHODS/DESIGN: This randomized controlled, clinical non-inferiority
      trial will be carried out at the Department of Orthopedics and Traumatology at
      Heidelberg University. Patients who suffer from tibial or femoral non-unions with
      a segmental bone defect of 2-5 cm and who are receiving Masquelet treatment will
      be included in the study. The resulting bone defect will either be filled with
      autologous bone and tricalciumphosphate (control group, N = 25) or BaG (S53P4)
      (study group, N = 25). Subsequent to operative therapy, all patients will receive
      the same standardized follow-up procedures. The primary endpoint of the study is
      union achieved 1year after surgery. DISCUSSION: The results from the current
      study will help evaluate the clinical effectiveness of this promising biomaterial
      in non-union therapy. In addition, this randomized trial will help to identify
      potential benefits and limitations regarding the use of BaG in Masquelet therapy.
      Data from the study will increase the knowledge about BaG as a bone graft
      substitute as well as identify patients possibly benefiting from Masquelet
      therapy using BaG and those who are more likely to fail, thereby improving the
      quality of non-union treatment. TRIAL REGISTRATION: German Clinical Trials
      Register (DRKS), ID: DRKS00013882 . Registered on 22 January 2018.

PMID- 29843767
TI  - Algorithm-based decision support for symptom self-management among adults with
      Cancer: results of usability testing.
AB  - BACKGROUND: It is essential that cancer patients understand anticipated symptoms,
      how to self-manage these symptoms, and when to call their clinicians. However,
      patients are often ill-prepared to manage symptoms at home. Clinical decision
      support (CDS) is a potentially innovative way to provide information to patients
      where and when they need it. The purpose of this project was to design and
      evaluate a simulated model of an algorithm-based CDS program for self-management
      of cancer symptoms. METHODS: This study consisted of three phases; development of
      computable algorithms for self-management of cancer symptoms using a modified
      ADAPTE process, evaluation of a simulated model of the CDS program, and
      identification of design objectives and lessons learned from the evaluation of
      patient-centered CDS. In phase 1, algorithms for pain, constipation and
      nausea/vomiting were developed by an expert panel. In phase 2, we conducted
      usability testing of a simulated symptom assessment and management intervention
      for self-care (SAMI-Self-Care) CDS program involving focus groups, interviews and
      surveys with cancer patients, their caregivers and clinicians. The Acceptability
      E-scale measured acceptability of the program. In phase 3, we developed design
      objectives and identified barriers to uptake of patient-centered CDS based on the
      data gathered from stakeholders. RESULTS: In phase 1, algorithms were reviewed
      and approved through a consensus meeting and majority vote. In phase 2, 24
      patients & caregivers and 13 clinicians participated in the formative evaluation.
      Iterative changes were made in a simulated SAMI-Self-Care CDS program.
      Acceptability scores were high among patients, caregivers and clinicians. In
      phase 3, we formulated CDS design objectives, which included: 1) ensure patient
      safety, 2) communicate clinical concepts effectively, 3) promote communication
      with clinicians, 4) support patient activation, and 5) facilitate navigation and
      use. We identified patient barriers and clinician concerns to using CDS for
      symptom self-management, which were consistent with the chronic care model, a
      theoretical framework used to enhance patient-clinician communication and patient
      self-management. CONCLUSION: Patient safety and tool navigation were critical
      features of CDS for patient self-management. Insights gleaned from this study may
      be used to inform the development of CDS resources for symptom self-management in
      patients with other chronic conditions.

PMID- 29843768
TI  - Egr-1 increases angiogenesis in cartilage via binding Netrin-1 receptor DCC
      promoter.
AB  - BACKGROUND: Osteoarthritis (OA) is a joint disease characterized by degradation
      of cartilage. The etiology of OA is still unclear. Vascular endothelial growth
      factor (VEGF) plays a key role of angiogenesis in the pathogenesis of OA and
      contributes to the angiogenesis of NT-1/DCC. Whether or not NT-1/DCC and VEGF
      interact in regulating angiogenesis of OA cartilage is not known. METHODS:
      Histological studies for CD34, VEGF, and safranin-O staining were performed to
      determine angiogenesis and cartilage tissue injury. ELISA indicated the level of
      pro-inflammation cytokines. Immunoblotting, immunoprecipitation, and
      electrophoretic mobility shift assay (EMSA) were performed to assay the
      expression and function of NT-1/DCC-VEGF signaling pathway. RESULTS: Our data
      indicated that VEGF expression was increased in cartilage tissue from OA rats,
      while the chondrocytes were disorganized, and cartilage degeneration was
      increasing in OA rats. The inflammation factors in articular cavity fluid were
      higher in the OA rats than in the sham. The protein expression of NT-1, DCC, and
      VEGF were increased in osteoarthritic cartilage. DCC was involved in the positive
      regulation of osteoarthritic angiogenesis by VEGF. Egr-1 expression was higher in
      OA rats than in sham rats. Egr-1 is a regulator of DCC promoter activity, and the
      binding is higher in OA rats than in sham rats. CONCLUSION: Our present study
      provides a mechanism by which Egr-1 induced angiogenesis via NT-1/DCC-VEGF
      pathway.

PMID- 29843769
TI  - Penile cancer in Maranhao, Northeast Brazil: the highest incidence globally?
AB  - BACKGROUND: The objectives of this study were to determine the minimum incidence
      of penile cancer in the poorest Brazilian state, and to describe the
      epidemiologic and clinical characteristics of patients diagnosed with the
      disease. METHODS: A retrospective study of 392 patients diagnosed with penile
      cancer in the three most important referral center in the state was conducted
      during 2004-2014. RESULTS: The age-standardized incidence was 6.15 per 100,000
      and the crude annual incidence was 1.18 per 100,000. More than half (61.1%) of
      the tumors were histological grades 2 and 3, and 66.4% of tumors were classified
      as at least stage T2. The average age of patients was 58.6 +/- 15.7 years (range,
      18 to 103 years), with 20.8% of patients <=40 years of age at diagnosis. The vast
      majority underwent penectomy (93%). Only 41.8% underwent lymphadenectomy, 58
      patients (14.8%) received chemotherapy, and 54 patients (13.8%) received
      radiotherapy. Stage 3/4 and vascular invasion were statically significant at
      disease-free survival analysis. CONCLUSION: The state of Maranhao has the highest
      incidence of penile cancer in Brazil and globally. Tumors are locally advanced
      and at the time of diagnosis, and there is a high frequency among young
      individuals. Patients have a low socioeconomic status, making it difficult to
      complete treatment and receive appropriate follow-up.

PMID- 29843770
TI  - Modelling the impact of larviciding on the population dynamics and biting rates
      of Simulium damnosum (s.l.): implications for vector control as a complementary
      strategy for onchocerciasis elimination in Africa.
AB  - BACKGROUND: In 2012, the World Health Organization set goals for the elimination
      of onchocerciasis transmission by 2020 in selected African countries.
      Epidemiological data and mathematical modelling have indicated that elimination
      may not be achieved with annual ivermectin distribution in all endemic foci.
      Complementary and alternative treatment strategies (ATS), including vector
      control, will be necessary. Implementation of vector control will require that
      the ecology and population dynamics of Simulium damnosum (sensu lato) be
      carefully considered. METHODS: We adapted our previous SIMuliid POPulation
      dynamics (SIMPOP) model to explore the impact of larvicidal insecticides on S.
      damnosum (s.l.) biting rates in different ecological contexts and to identify how
      frequently and for how long vector control should be continued to sustain
      substantive reductions in vector biting. SIMPOP was fitted to data from large
      scale aerial larviciding trials in savannah sites (Ghana) and small-scale ground
      larviciding trials in forest areas (Cameroon). The model was validated against
      independent data from Burkina Faso/Cote d'Ivoire (savannah) and Bioko (forest).
      Scenario analysis explored the effects of ecological and programmatic factors
      such as pre-control daily biting rate (DBR) and larviciding scheme design on
      reductions and resurgences in biting rates. RESULTS: The estimated efficacy of
      large-scale aerial larviciding in the savannah was greater than that of ground
      based larviciding in the forest. Small changes in larvicidal efficacy can have
      large impacts on intervention success. At 93% larvicidal efficacy (a realistic
      value based on field trials), 10 consecutive weekly larvicidal treatments would
      reduce DBRs by 96% (e.g. from 400 to 16 bites/person/day). At 70% efficacy, and
      for 10 weekly applications, the DBR would decrease by 67% (e.g. from 400 to 132
      bites/person/day). Larviciding is more likely to succeed in areas with lower
      water temperatures and where blackfly species have longer gonotrophic cycles.
      CONCLUSIONS: Focal vector control can reduce vector biting rates in settings
      where a high larvicidal efficacy can be achieved and an appropriate duration and
      frequency of larviciding can be ensured. Future work linking SIMPOP with
      onchocerciasis transmission models will permit evaluation of the impact of
      combined anti-vectorial and anti-parasitic interventions on accelerating
      elimination of the disease.

PMID- 29843771
TI  - Neutrophil extracellular traps induce aggregation of washed human platelets
      independently of extracellular DNA and histones.
AB  - BACKGROUND: The release of neutrophil extracellular traps (NETs), a mesh of DNA,
      histones and neutrophil proteases from neutrophils, was first demonstrated as a
      host defence against pathogens. Recently it became clear that NETs are also
      released in pathological conditions. NETs released in the blood can activate
      thrombosis and initiate a cascade of platelet responses. However, it is not well
      understood if these responses are mediated through direct or indirect
      interactions. We investigated whether cell-free NETs can induce aggregation of
      washed human platelets in vitro and the contribution of NET-derived extracellular
      DNA and histones to platelet activation response. METHODS: Isolated human
      neutrophils were stimulated with PMA to produce robust and consistent NETs. Cell
      free NETs were isolated and characterised by examining DNA-histone complexes and
      quantification of neutrophil elastase with ELISA. NETs were incubated with washed
      human platelets to assess several platelet activation responses. Using
      pharmacological inhibitors, we explored the role of different NET components, as
      well as main platelet receptors, and downstream signalling pathways involved in
      NET-induced platelet aggregation. RESULTS: Cell-free NETs directly induced dose
      dependent platelet aggregation, dense granule secretion and procoagulant
      phosphatidyl serine exposure on platelets. Surprisingly, we found that inhibition
      of NET-derived DNA and histones did not affect NET-induced platelet aggregation
      or activation. We further identified the molecular pathways involved in NET
      activated platelets. The most potent single modulator of NET-induced platelet
      responses included NET-bound cathepsin G, platelet Syk kinase, and P2Y12 and
      alphaIIbbeta3 receptors. CONCLUSIONS: In vitro-generated NETs can directly induce
      marked aggregation of washed human platelets. Pre-treatment of NETs with DNase or
      heparin did not reduce NET-induced activation or aggregation of human washed
      platelets. We further identified the molecular pathways activated in platelets in
      response to NETs. Taken together, we conclude that targeting certain platelet
      activation pathways, rather than the NET scaffold, has a more profound reduction
      on NET-induced platelet aggregation.

PMID- 29843772
TI  - Effectiveness of a standardized electronic admission order set for acute
      exacerbation of chronic obstructive pulmonary disease.
AB  - BACKGROUND: Variation in hospital management of patients with acute exacerbation
      of chronic obstructive pulmonary disease (AECOPD) may prolong length of stay,
      increasing the risk of hospital-acquired complications and worsening quality of
      life. We sought to determine whether an evidence-based computerized AECOPD
      admission order set could improve quality and reduce length of stay. METHODS: The
      order set was designed by a provincial COPD working group and implemented
      voluntarily among three physician groups in a Canadian tertiary-care teaching
      hospital. The primary outcome was length of stay for patients admitted during
      order set implementation period, compared to the previous 12 months. Secondary
      outcomes included length of stay of patients admitted with and without order set
      after implementation, all-cause readmissions, and emergency department visits.
      RESULTS: There were 556 admissions prior to and 857 admissions after order set
      implementation, for which the order set was used in 47%. There was no difference
      in overall length of stay after implementation (median 6.37 days (95% confidence
      interval 5.94, 6.81) pre-implementation vs. 6.02 days (95% confidence interval
      5.59, 6.46) post-implementation, p = 0.26). In the post-implementation period,
      order set use was associated with a 1.15-day reduction in length of stay (95%
      confidence interval - 0.5, - 1.81, p = 0.001) compared to patients admitted
      without the order set. There was no difference in readmissions. CONCLUSIONS: Use
      of a computerized guidelines-based admission order set for COPD exacerbations
      reduced hospital length of stay without increasing readmissions. Interventions to
      increase order set use could lead to greater improvements in length of stay and
      quality of care.

PMID- 29843773
TI  - Paraquat induced acute kidney injury and lung fibrosis: a case report from
      Bangladesh.
AB  - BACKGROUND: Since Bangladesh government issued a ban on the use of highly toxic
      WHO Class I pesticides, annual consumption of herbicides like Paraquat have been
      sharply increasing in the markets. Paraquat poisoning is an emerging public
      health threat and its high mortality rate is responsible for a significant number
      of deaths. Diagnostic limitations and unavailable sample at presentation have
      resulted in under-reporting and lack of awareness among the treating physicians,
      making Paraquat poisoning one of the most neglected toxicological emergencies.
      Herein, we present a case of Paraquat induced multi-organ failure and emphasis on
      pitfalls in the management. CASE PRESENTATION: An 18-years-old healthy male was
      admitted in Sylhet M.A.G Osmani Medical College Hospital with history of
      attempted suicide by Paraquat ingestion. On admission, he had high serum
      creatinine but otherwise asymptomatic. He was discharged on day 10 when his renal
      functions returned to normal. But On day 15, he started having respiratory
      symptoms-unresponsive to any of the local treatments he received, and by day 30,
      he developed overt lung fibrosis. We present sequential blood picture,
      radiographs and CT scans demonstrating Paraquat induced kidney and lung injury
      over the course of 30 days. CONCLUSION: Paraquat poisoning can lead to death and
      fatal long-term consequences. All cases of Paraquat poisoning, regardless of
      symptoms, must be hospitalized and observed for early detection of complications.
      Distribution of Paraquat should be restricted and/or banned as 38 other countries
      have done so, which we believe will greatly reduce poisoning related mortality.

PMID- 29843774
TI  - Post-trial follow-up methodology in large randomised controlled trials: a
      systematic review.
AB  - BACKGROUND: Randomised controlled clinical trials typically have a relatively
      brief in-trial follow-up period which can underestimate safety signals and fail
      to detect long-term hazards, which may take years to appear. Extended follow-up
      after the scheduled closure of the trial allows detection of both persistent or
      enhanced beneficial effects following cessation of study treatment (i.e. a legacy
      effect) and the emergence of possible adverse effects (e.g. development of
      cancer). METHODS: A systematic review was conducted following PRISMA guidelines
      to qualitatively compare post-trial follow-up methods used in large randomised
      controlled trials. Five bibliographic databases, including Medline and the
      Cochrane Library, and one trial registry were searched. All large randomised
      controlled trials (more than 1000 adult participants) published from March 2006
      to April 2017 were evaluated. Two reviewers screened and extracted data attaining
      > 95% concordance of papers checked. Assessment of bias in the trials was
      evaluated using the Cochrane Risk of Bias tool. RESULTS: Fifty-seven thousand
      three hundred and fifty-two papers were identified and 65 trials which had post
      trial follow-up (PTFU) were included in the analysis. The majority of trials used
      more than one type of follow-up. There was no evidence of an association between
      the retention rates of participants in the PTFU period and the type of follow-up
      used. Costs of PTFU varied widely with data linkage being the most economical. It
      was not possible to assess associations between risk of bias during the in-trial
      period and proportions lost to follow-up during the PTFU period. DISCUSSION: Data
      captured during the post-trial follow-up period can add scientific value to a
      trial. However, there are logistical and financial barriers to overcome. Where
      available, data linkage via electronic registries and records is a cost-effective
      method which can provide data on a range of endpoints. SYSTEMATIC REVIEW
      REGISTRATION: Not applicable for PROSPERO registration.

PMID- 29843775
TI  - On the journey from nematode to human, scientists dive by the zebrafish cell
      lineage tree.
AB  - Three recent single-cell papers use novel CRISPR-Cas9-sgRNA genome editing
      methods to shed light on the zebrafish cell lineage tree.

PMID- 29843776
TI  - Fatigue independently predicts different work disability dimensions in etanercept
      treated rheumatoid arthritis and ankylosing spondylitis patients.
AB  - BACKGROUND: Work disability remains a significant problem in ankylosing
      spondylitis (AS) and rheumatoid arthritis (RA), despite biological therapy. This
      study aimed to test the hypothesis that the prevalent symptom of fatigue
      longitudinally predicts work disability among RA and AS patients commencing
      etanercept. METHODS: Two observational studies, comprising RA and AS etanercept
      commencers, respectively, were analysed. Both provided data on work disability
      over 1 year and a comprehensive set of putative predictors, including fatigue. A
      series of repeated measures models were conducted, including baseline variables,
      visit (6/12 months), and the interaction between visit and each of the
      explanatory variables. RESULTS: A total of 1003 AS and 1747 RA patients were
      assessed. For AS, fatigue was significantly associated with presenteeism (linear
      mixed model coefficient 3.75, 95% confidence interval (CI) 2.14 to 5.36) and
      activity impairment (2.62, 1.26 to 3.98), but not with work productivity loss
      (1.81, -0.40 to 4.02) or absenteeism (generalised linear mixed model odds ratio
      (OR) 1.18, 95% CI 0.92 to 1.51). In RA, fatigue was associated with presenteeism
      (coefficient 3.44, 95% CI 2.17 to 4.70), activity impairment (1.52, 0.79 to
      2.26), work productivity loss (4.16, 2.47 to 5.85), and absenteeism (OR 1.23, 95%
      CI 1.02 to 1.49). The lack of significant interactions between fatigue and visit
      supported a consistent effect of baseline fatigue over time. CONCLUSIONS: Among
      patients beginning etanercept therapy, fatigue has a significant and independent
      effect on absenteeism, presenteeism, productivity loss, and activity impairment
      for RA patients and a significant but dimension-selective effect on work
      disability among AS patients. TRIAL REGISTRATION: ClinicalTrials.gov, NCT00544557
      . Registered on 16 October 2007. ClinicalTrials.gov, NCT00488475 . Registered on
      20 June 2006.

PMID- 29843777
TI  - Rare copy number variants analysis identifies novel candidate genes in heterotaxy
      syndrome patients with congenital heart defects.
AB  - BACKGROUND: Heterotaxy (Htx) syndrome comprises a class of congenital disorders
      resulting from malformations in left-right body patterning. Approximately 90% of
      patients with heterotaxy have serious congenital heart diseases; as a result, the
      survival rate and outcomes of Htx patients are not satisfactory. However, the
      underlying etiology and mechanisms in the majority of Htx cases remain unknown.
      The aim of this study was to investigate the function of rare copy number
      variants (CNVs) in the pathogenesis of Htx. METHODS: We collected 63 sporadic Htx
      patients with congenital heart defects and identified rare CNVs using an
      Affymetrix CytoScan HD microarray and real-time polymerase chain reaction.
      Potential candidate genes associated with the rare CNVs were selected by
      referring to previous literature related to left-right development. The
      expression patterns and function of candidate genes were further analyzed by
      whole mount in situ hybridization, morpholino knockdown, clustered regularly
      interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)
      mediated mutation, and over-expressing methods with zebrafish models. RESULTS:
      Nineteen rare CNVs were identified for the first time in patients with Htx. These
      CNVs include 5 heterozygous genic deletions, 4 internal genic duplications, and
      10 complete duplications of at least one gene. Further analyses of the 19 rare
      CNVs identified six novel potential candidate genes (NUMB, PACRG, TCTN2, DANH10,
      RNF115, and TTC40) linked to left-right patterning. These candidate genes
      exhibited early expression patterns in zebrafish embryos. Functional testing
      revealed that downregulation and over-expression of five candidate genes (numb,
      pacrg, tctn2, dnah10, and rnf115) in zebrafish resulted in disruption of cardiac
      looping and abnormal expression of lefty2 or pitx2, molecular markers of left
      right patterning. CONCLUSIONS: Our findings show that Htx with congenital heart
      defects in some sporadic patients may be attributed to rare CNVs. Furthermore,
      DNAH10 and RNF115 are Htx candidate genes involved in left-right patterning which
      have not previously been reported in either humans or animals. Our results also
      advance understanding of the genetic components of Htx.

PMID- 29843779
TI  - Grifolic acid induces GH3 adenoma cell death by inhibiting ATP production through
      a GPR120-independent mechanism.
AB  - BACKGROUND: Grifolic acid is a derivative of grifolin, an antitumor natural
      compound, and it was reported as an agonist of free fatty acid receptor GPR120.
      Little is known about its antitumor effects and the involvement of GPR120.
      METHODS: GH3 cells, the rat anterior pituitary adenoma cells, were cultured and
      the cell death was measured by MTT assay and Annexin V/PI staining. The
      mitochondrial membrane potential (MMP) of GH3 cells was measured by JC-1
      staining. Cellular ATP levels and the intracellular NAD/NADH ratio were measured.
      GPR120 expression in GH3 cells was observed by RT-PCR and Western Blot, and siRNA
      was used to inhibit GPR120 expression in GH3 cells. RESULTS: Grifolic acid dose-
      and time-dependently induced the necrosis of GH3 cells. Grifolic acid
      significantly reduced the mitochondrial membrane potential (MMP) and decreased
      cellular ATP levels in GH3 cells. In contrast, the MMP of isolated mitochondria
      was not decreased by grifolic acid. The intracellular NAD/NADH ratio was
      significantly increased by grifolic acid. GPR120 is expressed in GH3 cells, but
      GPR120 agonists such as EPA, GW9508 and TUG891 did not affect the viability of
      GH3 cells. Moreover, GPR120 siRNA knockdown showed no significant influence on
      grifolic acid-induced GH3 cell death. CONCLUSION: Grifolic acid induces GH3 cell
      death by decreasing MMP and inhibiting ATP production, which may be due to the
      inhibition of NADH production through a GPR120-independent mechanism.

PMID- 29843778
TI  - Searching for the proverbial needle in a haystack: advances in mosquito-borne
      arbovirus surveillance.
AB  - Surveillance is critical for the prevention and control of mosquito-borne
      arboviruses. Detection of elevated or emergent virus activity serves as a warning
      system to implement appropriate actions to reduce outbreaks. Traditionally,
      surveillance of arboviruses has relied on the detection of specific antibodies in
      sentinel animals and/or detection of viruses in pools of mosquitoes collected
      using a variety of sampling methods. These methods, although immensely useful,
      have limitations, including the need for a cold chain for sample transport, cross
      reactivity between related viruses in serological assays, the requirement for
      specialized equipment or infrastructure, and overall expense. Advances have
      recently been made on developing new strategies for arbovirus surveillance. These
      strategies include sugar-based surveillance, whereby mosquitoes are collected in
      purpose-built traps and allowed to expectorate on nucleic acid preservation cards
      which are submitted for virus detection. New diagnostic approaches, such as next
      generation sequencing, have the potential to expand the genetic information
      obtained from samples and aid in virus discovery. Here, we review the advancement
      of arbovirus surveillance systems over the past decade. Some of the novel
      approaches presented here have already been validated and are currently being
      integrated into surveillance programs. Other strategies are still at the
      experimental stage, and their feasibility in the field is yet to be evaluated.

PMID- 29843780
TI  - The implementation of the free maternal health policy in rural Northern Ghana:
      synthesised results and lessons learnt.
AB  - OBJECTIVE: A free maternal health policy was implemented under Ghana's National
      Health Insurance Scheme to promote the use of maternal health services. Under the
      policy, women are entitled to free services throughout pregnancy and at
      childbirth. A mixed methods study involving women, providers and insurance
      managers was carried out in the Kassena-Nankana municipality of Ghana. It
      explored the affordability, availability, acceptability and quality of services.
      In this manuscript, we present synthesised results categorised as facilitators
      and barriers to access as well as lessons learnt (implications). RESULTS:
      Reasonable waiting times, cleanliness of facilities as well as good interpersonal
      relationships with providers were the facilitators to access. Barriers included
      out of pocket payments, lack of, or inadequate supply of drugs and commodities,
      equipment, water, electricity and emergency transport. Four lessons
      (implications) were identified. Firstly, out of pocket payments persisted.
      Secondly, the health system was not strengthened before implementing the free
      maternal health policy. Thirdly, lower level facilities were poorly resourced.
      Finally, the lack of essential inputs and infrastructure affected quality of care
      and therefore, access to care. It is suggested that the Government of Ghana, the
      Health Insurance Scheme and other stakeholders improve the provision of resources
      to facilities.

PMID- 29843781
TI  - Daptomycin versus placebo as an adjunct to beta-lactam therapy in the treatment
      of Staphylococcus aureus bacteremia: study protocol for a randomized controlled
      trial.
AB  - BACKGROUND: Staphylococcus aureus bacteremia is associated with significant
      morbidity and mortality. To treat this infection, the current standard of care
      includes intravenous anti-staphylococcal beta-lactam antibiotics and obtaining
      adequate source control. Combination therapy with an aminoglycoside or rifampin,
      despite early promise, can no longer be routinely recommended due to an absence
      of proven benefit and risk of harm. Daptomycin is a rapidly acting bactericidal
      antibiotic that is approved for the treatment of Staphylococcus aureus bacteremia
      as monotherapy but has not been shown to be superior to the current standard of
      care. As demonstrated in vitro, the addition of daptomycin to beta-lactam therapy
      may result in enhanced anti-staphylococcal activity. Our objective is to assess
      the efficacy and safety of prescribing the combination of daptomycin with
      cefazolin or cloxacillin for the treatment of methicillin-susceptible
      Staphylococcus aureus (MSSA) bacteremia in adults. We hypothesize that adjunctive
      therapy with daptomycin will reduce the duration of bacteremia in this
      population. METHODS: The DASH-RCT trial is a randomized, double blind, placebo
      controlled trial designed per the Standard Protocol Items: Recommendation for
      Interventional Trials (SPIRIT) and Consolidated Standards of Reporting Trials
      (CONSORT) guidelines. We recruit adults with confirmed MSSA bacteremia, at the
      McGill University Health Center. Patients are eligible if they are 18 years or
      older, can receive cefazolin or cloxacillin monotherapy, and are enrolled within
      72 h of the first blood culture being drawn. Exclusion criteria include
      anaphylaxis to study drugs, having polymicrobial bacteremia, anticipated hospital
      admission for < 5 days, and healthcare team refusal. While receiving standard of
      care, study patients are randomized to a 5-day course of adjunctive daptomycin or
      placebo. The trial began in December 2016 and is expected to end in December
      2018, after recruiting an estimated 102 patients. DISCUSSION: The DASH-RCT will
      compare the use of daptomycin as an adjunct to an anti-staphylococcal beta-lactam
      versus placebo in the treatment of MSSA bacteremia. We believe that a short
      course of dual therapy will result in earlier eradication of bacteremia and that
      subsequent research could evaluate effects on metastatic infection, relapse,
      and/or mortality. Ongoing issues in the trial include a delay between
      presentation of infection, enrollment in the trial, and the potential for
      unrecognized deep foci of infection at diagnosis. TRIAL REGISTRATION:
      ClinicalTrials.gov, NCT02972983 . Registered on 25 November 2016. Trial protocol:
      http://individual.utoronto.ca/leet/dash/dashprotocol.pdf.

PMID- 29843782
TI  - Spontaneous regression of mantle cell lymphoma: a report of four cases.
AB  - BACKGROUND: Spontaneous regression has been reported in some indolent forms of
      lymphoma. Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm and has a
      poor prognosis. However, approximately 30% of MCL patients can exhibit indolent
      clinical behavior. To date, complete spontaneous regression of MCL has not been
      reported. CASE PRESENTATION: We describe four cases of spontaneous regression of
      MCL. At the time of presentation, these patients were asymptomatic, with lymph
      node enlargement and mild to moderate fluorodeoxyglucose (FDG) uptake on FDG
      positron emission tomography combined with computed tomography. One of the
      possible mechanisms of spontaneous regression of the tumor could be due to the
      host immune response through humoral and cellular immunity, which may have a role
      in the clearance of tumor cells. CONCLUSIONS: In this report, we support the use
      of a "wait and watch" strategy for MCL patients with no risk factors and indolent
      behavior. This strategy helps spare patients from further potentially harmful
      chemotherapy. In addition, we describe the phenomenon of spontaneous regression
      in MCL patients who are asymptomatic and have low-volume disease.

PMID- 29843783
TI  - Plasmodium falciparum msp1 and msp2 genetic diversity and allele frequencies in
      parasites isolated from symptomatic malaria patients in Bobo-Dioulasso, Burkina
      Faso.
AB  - BACKGROUND: In Burkina Faso, malaria remains the overall leading cause of
      morbidity and mortality accounting for 35.12% of consultations, 40.83% of
      hospitalizations and 37.5% of deaths. Genotyping of malaria parasite populations
      remains an important tool to determine the types and number of parasite clones in
      an infection. The present study aimed to evaluate the merozoite surface protein 1
      (msp1) and merozoite surface protein 2 (msp2) genetic diversity and allele
      frequencies in Bobo-Dioulasso, Burkina Faso. METHOD: Dried blood spots (DBS) were
      collected at baseline from patients with uncomplicated malaria in urban health
      centers in Bobo-Dioulasso. Parasite DNA was extracted using chelex-100 and
      species were identified using nested PCR. Plamodium falciparum msp1 and msp2
      genes were amplified by nested polymerase chain reaction (PCR) and PCR products
      were analyzed by electrophoresis on a 2.5% agarose gel. Alleles were categorized
      according to their molecular weight. RESULTS: A total of 228 blood samples were
      analyzed out of which 227 (99.9%) were confirmed as P. falciparum-positive and
      one sample classified as mixed infection for P. malaria and P. falciparum. In
      msp1, the K1 allelic family was predominant with 77.4% (162/209) followed
      respectively by the MAD20 allelic family with 41.3% and R033 allelic family with
      36%. In msp2, the 3D7 allelic family was the most frequently detected with 93.1 %
      compared to FC27 with 41.3%. Twenty-one different alleles were observed in msp1
      with 9 alleles for K1, 8 alleles for MAD20 and 4 alleles for R033. In msp2, 25
      individual alleles were detected with 10 alleles for FC27 and 15 alleles for 3D7.
      The mean multiplicity of falciparum infection was 1.95 with respectively 1.8
      (1.76-1.83) and 2.1 (2.03-2.16) for msp1 and msp2 (P = 0.01). CONCLUSIONS: Our
      study showed high genetic diversity and allelic frequencies of msp1 and msp2 in
      Plasmodium falciparum isolates from symptomatic malaria patients in Bobo
      Dioulasso.

PMID- 29843784
TI  - Effect of the nematophagous fungus Pochonia chlamydosporia on soil content of
      ascarid eggs and infection levels in exposed hens.
AB  - BACKGROUND: The nematophagous fungus Pochonia chlamydosporia can degrade ascarid
      (e.g. Ascaridia galli) eggs in agar and soil in vitro. However, it has not been
      investigated how this translates to reduced infection levels in naturally exposed
      chickens. We thus tested the infectivity of soil artificially contaminated with
      A. galli (and a few Heterakis gallinarum) eggs and treated with P.
      chlamydosporia. Sterilised and non-sterilised soils were used to examine any
      influence of natural soil biota. METHODS: Unembryonated eggs were mixed with
      sterilised (S)/non-sterilised (N) soil, either treated with the fungus (F) or
      left as untreated controls (C) and incubated (22  degrees C, 35 days) to allow
      eggs to embryonate and fungus to grow. Egg number in soil was estimated on days 0
      and 35 post-incubation. Hens were exposed to the soil (SC/SF/NC/NF) four times
      over 12 days by mixing soil into the feed. On day 42 post-first-exposure
      (p.f.e.), the hens were euthanized and parasites were recovered. Serum A. galli
      IgY level and ascarid eggs per gram of faeces (EPG) were examined on days -1 and
      36 (IgY) or 40 p.f.e. (EPG). RESULTS: Egg recovery in SF soil was substantially
      lower than in SC soil, but recovery was not significantly different between NF
      and NC soils. SF hens had a mean worm count of 76 whereas the other groups had
      means of 355-453. Early mature/mature A. galli were recovered from SF hens
      whereas hens in the other groups harboured mainly immature A. galli. Heterakis
      gallinarum counts were low overall, especially in SF. The SF post-exposure IgY
      response was significantly lower while EPG was significantly higher compared to
      the other groups. CONCLUSIONS: Pochonia chlamydosporia was very effective in
      reducing ascarid egg numbers in sterilised soil and thus worm burdens in the
      exposed hens. However, reduced exposure of hens shifted A. galli populations
      toward a higher proportion of mature worms and resulted in a higher faecal egg
      excretion within the study period. This highlights a fundamental problem in
      ascarid control: if not all eggs in the farm environment are inactivated, the
      resulting low level infections may result in higher contamination levels with
      associated negative long-term consequences.

PMID- 29843785
TI  - Oxidative stress impairs energy metabolism in primary cells and synovial tissue
      of patients with rheumatoid arthritis.
AB  - BACKGROUND: In this study, we examined the effect of oxidative stress on cellular
      energy metabolism and pro-angiogenic/pro-inflammatory mechanisms of primary
      rheumatoid arthritis synovial fibroblast cells (RASFC) and human umbilical vein
      endothelial cells (HUVEC). METHODS: Primary RASFC and HUVEC were cultured with
      the oxidative stress inducer 4-hydroxy-2-nonenal (4-HNE), and extracellular
      acidification rate, oxygen consumption rate, mitochondrial function and pro
      angiogenic/pro-inflammatory mechanisms were assessed using the Seahorse analyser,
      complex I-V activity assays, random mutation mitochondrial capture assays, enzyme
      linked immunosorbent assays and functional assays, including angiogenic tube
      formation, migration and invasion. Expression of angiogenic growth factors in
      synovial tissue (ST) was assessed by IHC in patients with rheumatoid arthritis
      (RA) undergoing arthroscopy before and after administration of tumour necrosis
      factor inhibitors (TNFi). RESULTS: In RASFC and HUVEC, 4-HNE-induced oxidative
      stress reprogrammed energy metabolism by inhibiting mitochondrial basal, maximal
      and adenosine triphosphate-linked respiration and reserve capacity, coupled with
      the reduced enzymatic activity of oxidative phosphorylation complexes III and IV.
      In contrast, 4-HNE elevated basal glycolysis, glycolytic capacity and glycolytic
      reserve, paralleled by an increase in mitochondrial DNA mutations and reactive
      oxygen species. 4-HNE activated pro-angiogenic responses of RASFC, which
      subsequently altered HUVEC invasion and migration, angiogenic tube formation and
      the release of pro-angiogenic mediators. In vivo markers of angiogenesis
      (vascular endothelial growth factor, angiopoietin 2 [Ang2], tyrosine kinase
      receptor [Tie2]) were significantly associated with oxidative damage and oxygen
      metabolism in the inflamed synovium. Significant reduction in ST vascularity and
      Ang2/Tie2 expression was demonstrated in patients with RA before and after
      administration of TNFi. CONCLUSIONS: Oxidative stress promotes metabolism in
      favour of glycolysis, an effect that may contribute to acceleration of
      inflammatory mechanisms and subsequent dysfunctional angiogenesis in RA.

PMID- 29843786
TI  - ELISA based on a recombinant Paragonimus heterotremus protein for serodiagnosis
      of human paragonimiasis in Thailand.
AB  - BACKGROUND: Paragonimus heterotremus is the main causative agent of
      paragonimiasis in Thailand. In Western blot diagnostic assays for paragonimiasis,
      the 35 kDa band present in crude P. heterotremus somatic extracts represents one
      of the known diagnostic bands. This study aimed to use a P. heterotremus cDNA
      library to create a recombinant version of this antigen for use in
      immunodiagnosis of paragonimiasis. METHODS: To accomplish this aim a cDNA
      expression library was constructed from adult worm mRNA and immuno-screened using
      antibodies from mice that had been immunized with the 35 kDa antigen. Screening
      resulted in the identification of an immunoreactive protein encoded by clone CE3,
      which contained an inserted sequence composed of 1292 base pairs. This clone was
      selected for use in the construction of a recombinant P. heterotremus protein
      because of its similarity to proactivator polypeptide. For recombinant protein
      expression, the CE3 gene sequence was inserted into the plasmid vector pRset and
      the resulting product had the expected molecular weight of 35 kDa. An IgG-ELISA
      based on the CE3 recombinant protein was evaluated by using sera from healthy
      individuals, from patients with paragonimiasis and other parasitic infections.
      This ELISA was performed by using human sera diluted at 1:2000, an optimized
      antigen concentration of 1 MUg/ml, and anti-human IgG diluted at 1:4000. RESULTS:
      The cut-off optical density value was set as the mean + 2 standard deviations
      (0.54), which resulted in the test having a sensitivity of 88.89% and a
      specificity of 95.51%. The recombinant antigen could react with antibodies from
      P. heterotremus, P. pseudoheterotremus and P. westermani infections. Cross
      reactivity occurred with a few cases of Blastocystis hominis infection (2/3),
      Bancroftian filariasis (1/10), opisthorchiasis (3/10), strongyloidiasis (4/10)
      and neurocysticercosis (1/11). CONCLUSIONS: Given the high test sensitivity and
      specificity, reflected in the low level of heterologous infection cross
      reactivity (11/215 serum samples), observed in the IgG-ELISA, this 35 kDa antigen
      may be useful for the detection of paragonimiasis.

PMID- 29843787
TI  - Sex differences in basal hypothalamic anorectic and orexigenic gene expression
      and the effect of quantitative and qualitative food restriction.
AB  - BACKGROUND: Research into energy balance and growth has infrequently considered
      genetic sex, yet there is sexual dimorphism for growth across the animal kingdom.
      We test the hypothesis that in the chicken, there is a sex difference in arcuate
      nucleus neuropeptide gene expression, since previous research indicates
      hypothalamic AGRP expression is correlated with growth potential and that males
      grow faster than females. Because growth has been heavily selected in some
      chicken lines, food restriction is necessary to improve reproductive performance
      and welfare, but this increases hunger. Dietary dilution has been proposed to
      ameliorate this undesirable effect. We aimed to distinguish the effects of gut
      fullness from nutritional feedback on hypothalamic gene expression and its
      interaction with sex. METHODS: Twelve-week-old male and female fast-growing
      chickens were either released from restriction and fed ad libitum or a restricted
      diet plus 15% w/w ispaghula husk, a non-nutritive bulking agent, for 2 days. A
      control group remained on quantitative restriction. Hypothalamic arcuate nucleus
      neuropeptides were measured using real-time PCR. To confirm observed sex
      differences, the experiment was repeated using only ad libitum and restricted fed
      fast-growing chickens and in a genetically distinct breed of ad libitum fed male
      and female chickens. Linear mixed models (Genstat 18) were used for statistical
      analysis with transformation where appropriate. RESULTS: There were pronounced
      sex differences: expression of the orexigenic genes AGRP (P < 0.001) and NPY (P <
      0.002) was higher in males of the fast-growing strain. In genetically distinct
      chickens, males had higher AGRP mRNA (P = 0.002) expression than females,
      suggesting sex difference was not restricted to a fast-growing strain. AGRP (P <
      0.001) expression was significantly decreased in ad libitum fed birds but was
      high and indistinguishable between birds on a quantitative versus qualitative
      restricted diet. Inversely, gene expression of the anorectic genes POMC and CART
      was significantly higher in ad libitum fed birds but no consistent sex
      differences were observed. CONCLUSION: Expression of orexigenic peptides in the
      avian hypothalamus are significantly different between sexes. This could be
      useful starting point of investigating further if AGRP is an indicator of growth
      potential. Results also demonstrate that gut fill alone does not reduce
      orexigenic gene expression.

PMID- 29843788
TI  - The lack of association between the burden of monosodium urate crystals assessed
      with dual-energy computed tomography or ultrasonography with cardiovascular risk
      in the commonly high-risk gout patient.
AB  - BACKGROUND: Gout is associated with higher cardiovascular risk that increases
      with disease severity. The objective of this study was to explore the
      relationship between the extent of monosodium urate (MSU) crystal deposition,
      assessed with ultrasonography (US) and dual-energy computed tomography (DECT),
      and cardiovascular risk. METHODS: Gout patients were included in this cross
      sectional study to undergo DECT scans for the assessment of total MSU volume
      deposition in the knees and feet, and US to evaluate the number of joints with
      the double contour (DC) sign. Participants were screened for traditional
      cardiovascular risk factors, and levels of the American College of Cardiology
      (ACC)/American Heart Association (AHA) 10-year risk for heart disease or stroke
      were calculated. The primary endpoint was the Spearman correlation coefficient
      rho between DECT MSU volume and cardiovascular risk. RESULTS: A total of 42
      patients were included; they were predominantly male (40/42) and aged 63.0 +/-
      13.2 years. Overall, 28/42 patients presented with the metabolic syndrome and the
      average 10-year coronary event or stroke risk according to the ACC/AHA (n = 33)
      was 21 +/- 15%. Correlations between DECT volumes of MSU deposits in the knees,
      feet, and knees + feet and cardiovascular risk according to the ACC/AHA were very
      poor, with rho = 0.18, -0.01, and 0.13, respectively. The was no correlation
      between the number of joints with the DC sign and cardiovascular risk (rho = 
      0.07). DECT MSU deposit volume was similar in patients with and without metabolic
      syndrome (p = 0.29). CONCLUSIONS: The extent of MSU burden does not increase the
      estimated risk of cardiovascular events in gout patients.

PMID- 29843789
TI  - An optimized library for reference-based deconvolution of whole-blood
      biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray.
AB  - Genome-wide methylation arrays are powerful tools for assessing cell composition
      of complex mixtures. We compare three approaches to select reference libraries
      for deconvoluting neutrophil, monocyte, B-lymphocyte, natural killer, and CD4+
      and CD8+ T-cell fractions based on blood-derived DNA methylation signatures
      assayed using the Illumina HumanMethylationEPIC array. The IDOL algorithm
      identifies a library of 450 CpGs, resulting in an average R2 = 99.2 across cell
      types when applied to EPIC methylation data collected on artificial mixtures
      constructed from the above cell types. Of the 450 CpGs, 69% are unique to EPIC.
      This library has the potential to reduce unintended technical differences across
      array platforms.

PMID- 29843790
TI  - Systematic evaluation of CRISPR-Cas systems reveals design principles for genome
      editing in human cells.
AB  - BACKGROUND: While CRISPR-Cas systems hold tremendous potential for engineering
      the human genome, it is unclear how well each system performs against one another
      in both non-homologous end joining (NHEJ)-mediated and homology-directed repair
      (HDR)-mediated genome editing. RESULTS: We systematically compare five different
      CRISPR-Cas systems in human cells by targeting 90 sites in genes with varying
      expression levels. For a fair comparison, we select sites that are either
      perfectly matched or have overlapping seed regions for Cas9 and Cpf1. Besides
      observing a trade-off between cleavage efficiency and target specificity for
      these natural endonucleases, we find that the editing activities of the smaller
      Cas9 enzymes from Staphylococcus aureus (SaCas9) and Neisseria meningitidis
      (NmCas9) are less affected by gene expression than the other larger Cas proteins.
      Notably, the Cpf1 nucleases from Acidaminococcus sp. BV3L6 and Lachnospiraceae
      bacterium ND2006 (AsCpf1 and LbCpf1, respectively) are able to perform precise
      gene targeting efficiently across multiple genomic loci using single-stranded
      oligodeoxynucleotide (ssODN) donor templates with homology arms as short as 17
      nucleotides. Strikingly, the two Cpf1 nucleases exhibit a preference for ssODNs
      of the non-target strand sequence, while the popular Cas9 enzyme from
      Streptococcus pyogenes (SpCas9) exhibits a preference for ssODNs of the target
      strand sequence instead. Additionally, we find that the HDR efficiencies of Cpf1
      and SpCas9 can be further improved by using asymmetric donors with longer arms 5'
      of the desired DNA changes. CONCLUSIONS: Our work delineates design parameters
      for each CRISPR-Cas system and will serve as a useful reference for future genome
      engineering studies.

PMID- 29843791
TI  - The role of adrenaline in cardiopulmonary resuscitation.
AB  - Adrenaline has been used in the treatment of cardiac arrest for many years. It
      increases the likelihood of return of spontaneous circulation (ROSC), but some
      studies have shown that it impairs cerebral microcirculatory flow. It is possible
      that better short-term survival comes at the cost of worse long-term outcomes.
      This narrative review summarises the rationale for using adrenaline, significant
      studies to date, and ongoing research.

PMID- 29843792
TI  - Safety and efficacy of obinutuzumab in Chinese patients with B-cell lymphomas: a
      secondary analysis of the GERSHWIN trial.
AB  - BACKGROUND: Patients with relapsed/refractory B-cell lymphomas have limited
      treatment options. GERSHWIN is an open-label, single-arm, phase Ib study of
      obinutuzumab monotherapy in Chinese patients with histologically documented CD20+
      relapsed/refractory chronic lymphocytic leukemia (CLL), diffuse large B-cell
      lymphoma (DLBCL), or follicular lymphoma (FL). The primary outcome measure of
      pharmacokinetics has been previously reported. We now present data on the
      secondary endpoint measures (e.g., safety, and efficacy and pharmacodynamics).
      METHODS: Patients received 1000 mg obinutuzumab intravenously on days 1, 8, and
      15 of cycle 1 (CLL patients; first dose split over 2 days), and on day 1 of
      cycles 2-8. Each cycle lasted for 21 days; the treatment period was 24 weeks. All
      subjects receiving at least one dose of obinutuzumab were included in the
      analysis of safety, efficacy, as well as pharmacodynamics. RESULTS: A total of 48
      patients (> 18 years of age) were enrolled (CLL: 12; DLBCL: 23; FL: 13). The
      subjects received a median of two lines of anticancer treatment prior to the
      enrollment. Thirty-five patients (72.9%) had at least one adverse event (AE). The
      most frequent AE was infusion-related reactions (15 patients; 31.3%), followed by
      pyrexia (11 patients; 22.9%). Treatment-related AEs were reported in 28 patients
      (58.3%), and included one death (interstitial lung disease). End-of-treatment
      (EoT) response rate was 33.3%. Best overall response rate was 47.9%. Most CLL
      patients achieved a partial response at EoT (58.3%). CD19+ depletion occurred in
      75.0% of the patients with CLL, and all patients with FL and DLBCL. CONCLUSIONS:
      The safety and efficacy of obinutuzumab monotherapy in Chinese patients with B
      cell lymphomas were similar to that observed in previous studies in non-Chinese
      patients; no new safety signals were observed. Clinical trial registration ID
      NCT01680991.

PMID- 29843793
TI  - Triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio and arterial
      stiffness in Japanese population: a secondary analysis based on a cross-sectional
      study.
AB  - BACKGROUND: Previous studies have revealed that triglyceride to high-density
      lipoprotein cholesterol (HDL-C) ratio (henceforth TG/HDL-C) is one of major risk
      factors of cardiovascular diseases, insulin resistance and metabolism syndrome.
      However, there are fewer scientific dissertations about the correlation between
      TG/HDL-C and bapWV. This study was undertaken to investigate the relationship
      between Triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio
      and brachial-ankle pulse wave velocity (baPWV) in Japanese. METHODS: The present
      study was a cross-sectional study. 912 Japanese men and women, aging 24-84 years
      old, received a health medical a health check-up program including the results
      from baPWV inspection and various standardized questionnaire in a health
      examination Center in Japan. Main outcome measures included TG/HDL-C ratio,
      baPWV, fatty liver, postmenopausal status. Abdominal ultrasonography was used to
      diagnose fatty liver. Postmenopausal state was defined as beginning 1 year after
      the cessation of menses. It was noted that the entire study was completed by
      Fukuda et al., and uploaded the data to the DATADRYAD website. The author only
      used this data for secondary analysis. RESULTS: After adjusting potential
      confounders (age, sex, BMI, SBP, DBP, AST, ALT, GGT, uric acid, fasting glucose,
      TC, LDL, eGFR, smoking and exercise status, fatty liver, alcohol consumption and
      ABI), non-linear relationship was detected between TG/HDL-C and baPWV, whose
      point was 5.6. The effect sizes and the confidence intervals on the left and
      right sides of inflection point were 12.7 (1.9 to 23.5) and - 16.7 (- 36.8 to
      3.3), respectively. Subgroup analysis showed, in participants with excessive
      alcohol consumption (more than 280 g/week), that TG/HDL-C had a negative
      correlation with BAPWV (beta = - 30.7, 95%CI (- 53.1, - 8.4)), and the P for
      interaction was less than 0.05, CONCLUSION: The relationship between TG/HDL-C and
      baPWV is non-linear. TG/HDL-C was positively related with baPWV when TG/HDL-C is
      less than 5.6. In addition, while the trend is opposite in excessive alcoholic
      subjects.

PMID- 29843794
TI  - The opposite roles of PAS-5 and Galectin-1 in immune response during the early
      infection of Angiostrongylus cantonensis.
AB  - BACKGROUND: Angiostrongylus cantonensis is a human zoonotic nematode parasite.
      Our previous studies found that PAS-5 and Galectin-1 (Gal-1) proteins of A.
      cantonensis could be strongly recognized by sera from mice infected with A.
      cantonensis. In this study, we further evaluated the potential roles of these two
      proteins in the induction of immune response in mice. METHODS: Mice were
      immunized with recombinant PAS-5 or Gal-1 and then challenged with 30 infective
      A. cantonensis larvae following the last immunization. We then examined the
      infected mice for changes in serum antibodies and cytokines by ELISA, CD4+ T
      cells and CD4+CD25+FoxP3+ regulatory T cells (Tregs) by flow cytometry, and
      tissue damage severity by hematoxylin-eosin (H&E) staining. RESULTS: Compared
      with control mice, the PAS-5-immunized mice exhibited increased levels of serum
      antibodies and cytokines (except for IL-10) at different time points post
      infection. PAS-5 immunization promoted significant proliferation of CD4+ T cells,
      and caused more damage in the brain tissue. Vaccination with Gal-1 inhibited the
      production of antibodies (except for IgG1) and IFN-gamma, but promoted the
      expression of IL-4 and IL-10. Gal-1 immunization results in significant increases
      in the levels of CD4+CD25+FoxP3+ Tregs, and mild inflammatory changes.
      CONCLUSIONS: Taken together, our findings show that PAS-5 enhances, but Gal-1
      inhibits the immune response in the early stage of A. cantonensis infections.

PMID- 29843795
TI  - Is telephone health coaching a useful population health strategy for supporting
      older people with multimorbidity? An evaluation of reach, effectiveness and cost
      effectiveness using a 'trial within a cohort'.
AB  - BACKGROUND: Innovative ways of delivering care are needed to improve outcomes for
      older people with multimorbidity. Health coaching involves 'a regular series of
      phone calls between patient and health professional to provide support and
      encouragement to promote healthy behaviours'. This intervention is promising, but
      evidence is insufficient to support a wider role in multimorbidity care. We
      evaluated health coaching in older people with multimorbidity. METHODS: We used
      the innovative 'Trials within Cohorts' design. A cohort was recruited, and a
      trial was conducted using a 'patient-centred' consent model. A randomly selected
      group within the cohort were offered the intervention and were analysed as the
      intervention group whether they accepted the offer or not. The intervention
      sought to improve the skills of patients with multimorbidity to deal with a range
      of long-term conditions, through health coaching, social prescribing and low
      intensity support for low mood. RESULTS: We recruited 4377 older people, and 1306
      met the eligibility criteria (two or more long-term conditions and moderate
      'patient activation'). We selected 504 for health coaching, and 41% consented.
      More than 80% of consenters received the defined 'dose' of 4+ sessions. In an
      intention-to-treat analysis, those selected for health coaching did not improve
      on any outcome (patient activation, quality of life, depression or self-care)
      compared to usual care. We examined health care utilisation using hospital
      administrative and self-report data. Patients selected for health coaching
      demonstrated lower levels of emergency care use, but an increase in the use of
      planned services and higher overall costs, as well as a quality-adjusted life
      year (QALY) gain. The incremental cost per QALY was L8049, with a 70-79%
      probability of being cost-effective at conventional levels of willingness to pay.
      CONCLUSIONS: Health coaching did not lead to significant benefits on the primary
      measures of patient-reported outcome. This is likely related to relatively low
      levels of uptake amongst those selected for the intervention. Demonstrating
      effectiveness in this design is challenging, as it estimates the effect of being
      selected for treatment, regardless of whether treatment is adopted. We argue that
      the treatment effect estimated is appropriate for health coaching, a proactive
      model relevant to many patients in the community, not just those seeking care.
      TRIAL REGISTRATION: International Standard Randomised Controlled Trial Number (
      ISRCTN12286422 ).

PMID- 29843796
TI  - Level of modern health care seeking behaviors among mothers having under five
      children in Dangila town, north West Ethiopia, 2016: a cross sectional study.
AB  - BACKGROUND: Health seeking behavior is an action taken by an individual who
      perceive to have a health problem. In most developing countries including
      Ethiopia the health of the children is strongly dependant on maternal health care
      behavior. Most childhood morbidities and mortalities are associated with low
      level of mothers health care seeking behavior. Therefore, the objective of this
      study was to assess level of modern health care seeking behavior among mothers
      having under five children in Dangila town, North West Ethiopia. METHODS:
      Community based quantitative cross-sectional study was conducted from April 15 to
      May 15, 2016. Systematic random sampling technique was used to select study
      participants. A total of273 mothers with children less than five years were
      included in this study. The data was collected from all five Kebeles using
      interviewer administered questionnaire. Descriptive and inferential statistics
      were used to present the data. Both bivariate and multivariate logistic
      regression analyses were used to identify factors associated with level of modern
      health care seeking behavior. RESULTS: Prevalence of modern health care seeking
      behavior was 82.1%. Age of mothers (AOR = 2.4(1.1, 5.3), age of the child (AOR =
      6.7(2.8, 22.2), severity of illness (AOR = 5.2(1.2, 22.6) and family number (AOR
      = 6.4(2.1, 20.2) were predictors of modern health care seeking behavior among
      mothers. CONCLUSIONS: Majority of the mothers preferred to take their children to
      modern health care when they got illness. Age of children, age of mother, number
      of family and severity of illness were the determinant factors for modern health
      care seeking behavior. Therefore, health care services should be strengthened at
      community level through community integrated management of childhood illness,
      information, education communication / behavioral change communication strategies
      to improve mothers health care seeking behaviors.

PMID- 29843797
TI  - Preparation of an epitope-based recombinant diagnostic antigen specific to anti
      phospholipase A2 receptor 1 antibodies.
AB  - BACKGROUND: According to recent studies, the phospholipase A2 receptor 1 (PLA2R1)
      may be used as a biomarker to diagnose idiopathic membranous nephropathy (iMN).
      Moreover, the immune-dominant regions of PLA2R1 have been identified. The aim of
      the present study was to construct a diagnostic antigen based on the immune
      dominant region of PLA2R1 and develop a specific serological detection method for
      PLA2R1 antibodies. RESULTS: The tandem multi-epitope diagnostic antigen
      (designated 'R101'), which includes aa 39-130 (CysR), aa 238-356 (CTLD1), and aa
      1136-1234 (CTLD7) of PLA2R1; thioredoxin at the N-terminus; and a His tag at the
      C-terminus, was prepared at a concentration of 2.36 mg/mL and purity of 97.32%
      using Escherichia coli expression and affinity and anion exchange chromatography
      purification. The integrity and antigenicity of the R101 protein was demonstrated
      by western blot analysis using anti-Trx, anti-His, and anti-PLA2R1 monoclonal
      antibodies as the primary antibodies. By analysing 120 positive serum samples
      identified by biopsy-proven iMN (gold standard) and 240 negative samples
      identified by an established ELISA based on R101 protein, we concluded that the
      cut-off value, kappa value, sensitivity, specificity, and agreement rate were
      0.305, 0.881, 91.67, 96.25, and 94.72% respectively. The receiver operating
      characteristic (ROC) curve illustrated that the diagnostic accuracy and
      practicability of the ELISA was excellent. The area under the curve was 0.986.
      CONCLUSIONS: Using prokaryotic expression and chromatography purification, immune
      dominant regions of PLA2R1 with excellent antigenicity can be prepared and
      applied to serological detection of PLA2R1 antibodies.

PMID- 29843798
TI  - The NK1 receptor antagonist NKP608 inhibits proliferation of human colorectal
      cancer cells via Wnt signaling pathway.
AB  - BACKGROUND: Neurokinin1 (NK1) receptor has played a vital role in the development
      of tumor. However, NKP608 as a NK1 receptor antagonist whether has the effect of
      the resistance of colorectal cancer is still unclear. Thereby, in this study, we
      investigated the role of NKP608 on human colorectal cancer and explored the
      underlying mechanism. METHODS: The cell proliferation of colorectal cancer cells
      was detected by cell counting kit-8 (CCK8) assay, cell migration and invasion
      were assessed by transwell assay, the apoptotic ratio of cells was assessed by
      Annexin V-fluorescein isothiocyanate/propidium iodide stained and flow cytometry.
      The involvement of molecular mechanisms was examined by western blot. RESULTS: In
      this study, we found that NKP608 inhibited the proliferation, migration/invasion
      of HCT116 cells. In addition, NKP608 reduced expressions of Wnt-3a, beta-catenin,
      Cyclin D1, and (vascular endothelial growth factor) VEGF while induced expression
      of E-Cadherin. Furthermore, flow cytometry analyzed that NKP608 induced apoptosis
      of HCT116 cells, consistently, western blotting detecting of apoptosis-related
      proteins revealed that NKP608 downregulated Bcl-2 while upregulated Bax and
      Active-Caspase-3. CONCLUSIONS: Taken together, our results demonstrated that
      NKP608 inhibited colorectal cancer cell proliferation, migration and invasion via
      suppressing the Wnt/beta-catenin signaling pathway. Therefore, NKP608 might
      represent a promising therapeutic agent in the treatment of colorectal cancer.

PMID- 29843799
TI  - The impact of chronic airway disease on symptom severity and global suffering in
      Canadian rhinosinusitis patients.
AB  - BACKGROUND: Patients with Chronic Rhinosinusitis (CRS) can suffer from a
      significant decline in their quality of life. CRS patients have a high prevalence
      of comorbid conditions and it is important to understand the impact of these
      conditions on their CRS-related quality of life. This study measures the impacts
      of chronic pulmonary comorbidities on quality of life, pain, and depression
      scores among patients with CRS awaiting Endoscopic Sinus Surgery (ESS). METHODS:
      This study is based on cross-sectional analysis of prospectively collected
      patient-reported outcome data collected pre-operatively from patients waiting for
      ESS. Surveys were administered to patients to assess sino-nasal morbidity (SNOT
      22), depression and pain. The impact of pulmonary comorbidity on SNOT-22 scores,
      pain and depression was measured. RESULTS: Two hundred fifthy-three patients were
      included in the study, 91 with chronic pulmonary comorbidity. The mean SNOT-22
      scores were significantly higher among patients with chronic pulmonary
      comorbidities than among patients without (37 and 48, respectively). This
      difference is large enough to be clinically significant. Patients with chronic
      pulmonary comorbidities reported slightly higher depression scores than those
      without. CONCLUSIONS: This study found that among CRS patients waiting for ESS,
      chronic pulmonary comorbidities are strongly associated with significantly higher
      symptom burden.

PMID- 29843800
TI  - Is there a survival benefit from adjuvant chemotherapy for patients with liver
      oligometastases from colorectal cancer after curative resection?
AB  - BACKGROUND: Although colorectal oligometastases to the liver can potentially be
      cured with aggressive local ablation, the efficacy of adjuvant chemotherapy (ACT)
      for such metastasis remains unclear. The present study explored the effects of
      ACT on patients with colorectal liver oligometastases (CLO) after curative
      resections and aimed to identify patients who could benefit from ACT. METHODS: We
      retrospectively analyzed 264 eligible patients with CLO who underwent curative
      resection between September 1999 and June 2015. Recurrence-free survival (RFS)
      and overall survival (OS) were analyzed using the Kaplan-Meier method and log
      rank test; prognostic factors were a by Cox regression modeling. RESULTS: Among
      264 patients, 200 (75.8%) patients received ACT and 64 (24.2%) did not receive
      ACT. These two groups did not significantly differ in clinicopathologic
      characteristics, and had comparable 3-year OS and RFS rates (RFS: 42.1% vs.
      45.7%, P = 0.588; OS: 69.7% vs. 62.7%, P = 0.446) over a median follow-up
      duration of 35.5 months, irrespective of preoperative chemotherapy. ACT markedly
      improved 3-year OS in high-risk patients with Memorial Sloan-Kettering Cancer
      Center clinical risk scores (MSKCC-CRS) of 3-5 (68.2% vs. 33.8%, P = 0.015), but
      presented no additional benefit in patients with MSKCC-CRS of 0-2 (72.2% vs.
      78.6%, P = 0.834). In multivariate analysis, ACT was independently associated
      with improved OS in patients with MSKCC-CRS of 3-5. CONCLUSIONS: ACT might offer
      a prognostic benefit in high-risk patients with CLOs after curative liver
      resection, but not in low-risk patients. Therefore, patients' risk status should
      be determined before ACT administration to optimize postoperative therapeutic
      strategies.

PMID- 29843801
TI  - When symptoms don't fit: a case series of conversion disorder in the pediatric
      otolaryngology practice.
AB  - BACKGROUND: Conversion disorder refers to functional bodily impairments that can
      be precipitated by high stress situations including trauma and surgery. Symptoms
      of conversion disorder may mimic or complicate otolaryngology diseases in the
      pediatric population. CASE PRESENTATION: In this report, the authors describe 3
      cases of conversion disorder that presented to a pediatric otolaryngology-head
      and neck surgery practice. This report highlights a unique population of patients
      who have not previously been investigated. The clinical presentation and
      management of these cases are discussed in detail. Non-organic otolaryngology
      symptoms of conversion disorder in the pediatric population are reviewed. In
      addition, we discuss the challenges faced by clinicians in appropriately
      identifying and treating these patients and present an approach to management of
      their care. CONCLUSION: In this report, the authors highlight the importance of
      considering psychogenic illnesses in patients with atypical clinical
      presentations of otolaryngology disorders.

PMID- 29843802
TI  - Challenges to the Israeli healthcare system: attracting medical students to
      primary care and to the periphery.
AB  - BACKGROUND: The greatest challenges facing healthcare systems include ensuring a
      sufficient supply of primary care physicians and physicians willing to work in
      rural or peripheral areas. Especially challenging is enticing young physicians to
      practice primary care in rural/peripheral areas. Identifying medical students
      interested in primary care and in residencies in Israel's periphery should aid
      the healthcare leadership. It may be particularly important to do so during the
      clinical years, as this is the stage at which many future physicians begin to
      crystallize their specialty and location preferences. METHODS: Questionnaires,
      distributed to 6 consecutive 5th-year classes of the Hebrew University - Hadassah
      School of Medicine, from 2010 to 2016, elicited information on criteria for
      choosing a career specialty, criteria for choosing a residency program and
      whether one-time monetary grants authorized in the 2011 physicians' union
      contract would attract students to residencies in the periphery. RESULTS:
      Completed questionnaires were returned by 511 of 740 (69%) students. Ninety-eight
      (19%) were interested in a primary care residency, 184 (36%) were unsure and 229
      (45%) were not interested. Students interested in primary care were significantly
      less interested in specialties that perform procedures/surgeries and in joining a
      medical school faculty, while being more inclined towards specialties dealing
      with social problems, controllable lifestyles and working limited hours. The
      percentage of students interested in primary care was stable during the study
      period. Forty-eight of the students indicated interest in residencies in the
      country's periphery, and 42% of them were also interested in primary care
      residencies. Overall, only 3.7% of students were interested in both a primary
      care residency and a residency in the periphery. Thirty percent of the students
      indicated that the monetary incentives tempted them to consider a residency in
      the periphery. Fifty-three percent of these students reported that they did not
      yet know the geographic area where they wished to do their residency, as compared
      to only 22% among those not interested in incentives. CONCLUSIONS: This study
      provides the healthcare leadership with information on the characteristics of the
      students at a centrally-located medical school who tend to be more interested in
      primary care and in working in the periphery. Specifically, the study found that
      students interested in primary care desire a positive life/work balance,
      something that Israeli non-hospital primary care practice provides. Students
      considering residencies in the periphery were similarly inclined. Moreover, about
      a third of students had positive thoughts about monetary incentives for
      residencies in peripheral hospitals. These students should be identified early
      during their clinical experience so that attempts to recruit them to the
      periphery can commence before their specialty and location preferences have fully
      crystallized. Parallel studies should be performed at additional Israeli medical
      schools.

PMID- 29843803
TI  - Immunohistochemical expression and prognostic value of PD-L1 in Extrapulmonary
      small cell carcinoma: a single institution experience.
AB  - BACKGROUND: Extrapulmonary small cell carcinomas (ESCC) are rare but aggressive
      tumors. Relapses are common despite treatment with chemotherapy and/or
      radiotherapy. Prospective data for treatment of ESCC are lacking; treatment of
      these cancers usually incorporates lung small cell carcinoma treatment
      recommendations. Cancer staging remains the most important prognostic factor.
      Cancer immunotherapy targeting the PD-1/PD-L1 pathway has shown efficacy in
      multiple tumor types, and could be an appealing treatment strategy for these rare
      tumors. METHODS: We investigated PD-L1 expression by immunochemistry (IHC) in
      ESCCs diagnosed at University of Massachusetts Medical Center, from 1999 to 2016.
      34 cases with sufficient material were selected for PD-L1 IHC analysis using
      clone E1L3N. PD-L1 expression was evaluated using the combined positive score
      (CPS). Retrospective chart review was performed. We evaluated the incidence and
      prognostic value of PD-L1 expression in ESCC at our institution. RESULTS: Twelve
      out 34 cases (35%) had PD-L1 CPS scores >=1. Ten cases had CPS scores ranging 1
      5, whereas 2 cases had CPS scores > 80. The overall response rate to the standard
      chemotherapy with/without radiotherapy in the PD-L1 positive group was 80% versus
      67% for the PDL-1 negative group (p-value 0.67). The median overall survival for
      the PD-L1 positive group, regardless of stage, was 11.5 months versus 7 months
      for PD-L1 negative group (p-value 0.34). Patients with limited stage disease with
      positive PD-L1 had a median survival of 53 months compared to 15 months for
      patients with PD-L1 negative limited stage (p-value 0.80). CONCLUSIONS: This
      study showed that at least one third of our ESCC tissue samples expressed PD-L1.
      There was a trend for higher response rates to the standard chemotherapy
      with/without radiotherapy and improved survival in PD-L1 positive patients.
      Further studies are required to understand the implications of immune
      dysregulation in these aggressive tumors. PD-L1/PD-1 inhibitors should be
      investigated in this group of patients.

PMID- 29843804
TI  - Building a patient-centered and interprofessional training program with patients,
      students and care professionals: study protocol of a participatory design and
      evaluation study.
AB  - BACKGROUND: A common approach to enhance patient-centered care is training care
      professionals. Additional training of patients has been shown to significantly
      improve patient-centeredness of care. In this participatory design and evaluation
      study, patient education and medical education will be combined by co-creating a
      patient-centered and interprofessional training program, wherein patients,
      students and care professionals learn together to improve patient-centeredness of
      care. METHODS: In the design phase, scientific literature regarding interventions
      and effects of student-run patient education will be synthesized in a scoping
      review. In addition, focus group studies will be performed on the preferences of
      patients, students, care professionals and education professionals regarding the
      structure and content of the training program. Subsequently, an intervention plan
      of the training program will be constructed by combining these building blocks.
      In the evaluation phase, patients with a chronic disease, that is rheumatoid
      arthritis, diabetes and hypertension, and patients with an oncologic condition,
      that is colonic cancer and breast cancer, will learn together with medical
      students, nursing students and care professionals in training program cycles of
      three months. Process and effect evaluation will be performed using the plan-do
      study-act (PDSA) method to evaluate and optimize the training program in care
      practice and medical education. A modified control design will be used in PDSA
      cycles to ensure that students who act as control will also benefit from
      participating in the program. DISCUSSION: Our participatory design and evaluation
      study provides an innovative approach in designing and evaluating an intervention
      by involving participants in all stages of the design and evaluation process. The
      approach is expected to enhance the effectiveness of the training program by
      assessing and meeting participants' needs and preferences. Moreover, by using
      fast PDSA cycles and a modified control design in evaluating the training
      program, the training program is expected to be efficiently and rapidly
      implemented into and adjusted to care practice and medical education.

PMID- 29843805
TI  - Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R
      expressing ALS mouse model.
AB  - Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
      characterized by a selective loss of upper and lower motor neurons. Recent
      studies have shown that mutations in SQSTM1 are linked to ALS. SQSTM1 encodes
      SQSTM1/p62 that regulates not only autophagy via the association with MAP1LC3/LC3
      and ubiquitinated proteins but also the KEAP1-NFE2L2/Nrf2 anti-oxidative stress
      pathway by interacting with KEAP1. Previously, we have demonstrated that loss of
      SQSTM1 exacerbates disease phenotypes in a SOD1H46R-expressing ALS mouse model.
      To clarify the effects of SQSTM1 overexpression in this model, we generated
      SQSTM1 and SOD1 H46R double-transgenic (SQSTM1;SOD1 H46R ) mice. SQSTM1;SOD1 H46R
      mice exhibited earlier disease onset and shorter lifespan than did SOD1 H46R
      mice. Conversely, disease progression after the onset rather slightly but
      significantly slowed in SQSTM1;SOD1 H46R mice. However, there were observable
      differences neither in the number of Nissl positive neurons nor in the
      distribution of ubiquitin-positive and/or SQSTM1-positive aggregates between SOD1
      H46R and SQSTM1;SOD1 H46R mice. It was noted that these protein aggregates were
      mainly observed in neuropil, and partly localized to astrocytes and/or microglia,
      but not to MAP2-positive neuronal cell bodies and dendrites at the end-stage of
      disease. Nonetheless, the biochemically-detectable insoluble SQSTM1 and poly
      ubiquitinated proteins were significantly and progressively increased in the
      spinal cord of SQSTM1;SOD1 H46R mice compared to SOD1 H46R mice. These results
      suggest that overexpression of SQSTM1 in SOD1 H46R mice accelerates disease onset
      by compromising the protein degradation pathways.

PMID- 29843807
TI  - What is the impact of regulatory guidance and expiry of drug patents on dementia
      drug prescriptions in England? A trend analysis in the Clinical Practice Research
      Datalink.
AB  - BACKGROUND: Drugs for dementia have been available in England since 1997. Since
      their launch, there have been several changes to national guidelines and
      initiatives that may have influenced prescribing. These include changes in
      National Institute for Health and Care Excellence (NICE) guidance, several
      government dementia strategies, the addition of dementia to the Quality and
      Outcomes Framework (QOF), and the expiry of drug patents. Despite this, there has
      been little research into the effect of these events on prescribing. This paper
      examines prescribing trends in England using data from the U.K. Clinical Practice
      Research Datalink since the launch of drugs for dementia up to 1st January 2016.
      METHODS: We considered the monthly proportion of patients eligible for treatment,
      with a diagnosis of probable Alzheimer's disease, receiving their first
      prescription for each drug class-namely, acetylcholinesterase (AChE) inhibitors
      (donepezil, rivastigmine, galantamine) and N-methyl-D-aspartate (NMDA) receptor
      antagonists (memantine). Trend analysis using joinpoint models was then applied
      to identify up to two trend changes per treatment of interest. RESULTS: The
      overall trend was for increasing prescriptions in each drug class over the period
      in which they were studied. This was indicated by the average monthly percentage
      change, which was 6.0% (95% CI, - 6.4 to 19.9; June 1997 to December 2015) for
      AChE inhibitors and 15.4% (95% CI, - 77.1 to 480.9; January 2003 to December
      2015) for NMDA receptor antagonists. Prescriptions of AChE inhibitors increased
      at the end of 2012, probably in response to the patent expiry of these drugs
      earlier that year. The Prime Minister's Dementia Challenge launched in May 2012
      may also have contributed to the observed increase. However, neither this
      strategy nor patent expiry appeared to influence prescriptions of NMDA receptor
      antagonists. Instead trend changes in this drug class were driven by NICE
      guidance released in 2011 that allowed access to these drugs outside of clinical
      trials. CONCLUSIONS: Dementia drug prescribing does not always respond to factors
      such as regulatory guidance, recommendations, or patent expiry, and when it does,
      not necessarily in a predictable way. This suggests that communication with
      clinicians may need to be improved to use drugs for dementia more cost
      effectively.

PMID- 29843808
TI  - Long-term use of selective digestive decontamination in an ICU highly endemic for
      bacterial resistance.
AB  - BACKGROUND: We examined whether long-term use of selective digestive tract
      decontamination (SDD) was effective in reducing intensive care unit (ICU)
      acquired infection and antibiotic consumption while decreasing colistin-,
      tobramycin-, and most of the antibiotic-resistant colonization rates in a mixed
      ICU with a high endemic level of multidrug-resistant bacteria (MDRB). METHODS: In
      this cohort study, which was conducted in a 30-bed medical-surgical ICU, clinical
      outcomes before (1 year, non-SDD group) and after (4 years) implementation of SDD
      were compared. ICU patients who were expected to require tracheal intubation for
      > 48 hours were given a standard prophylactic SDD regimen. Oropharyngeal and
      rectal swabs were obtained on admission and once weekly thereafter. RESULTS: ICU
      acquired infections occurred in 110 patients in the non-SDD group and in 258 in
      the SDD group. A significant (P <  0.001) reduction of infections caused by MDRB
      (risk ratio [RR], 0.31; 95% CI, 0.23-0.41) was found after SDD and was associated
      with low rates of colistin- and tobramycin-resistant colonization. Colistin- and
      tobramycin-acquired increasing rate of ICU colonization resistance by 1000 days,
      adjusted by the rate of resistances at admission, was nonsignificant (0.82; 95%
      CI, 0.56 to 1.95; 1.13; 95% CI, 0.75 to 1.70, respectively). SDD was also a
      protective factor for ICU-acquired infections caused by MDR gram-negative
      pathogens and Acinetobacter baumannii in the multivariate analysis. In addition,
      a significant (P <  0.001) reduction of ventilator-associated pneumonia (VAP)
      (RR, 0.43; 95% CI, 0.32-0.59) and secondary bloodstream infection (BSI) (RR,
      0.35; 95% CI, 0.24-0.52) was found. A decrease in antibiotic consumption was also
      observed. CONCLUSIONS: Treatment with SDD during 4 years was effective in an ICU
      setting with a high level of resistance, with clinically relevant reductions of
      infections caused by MDRB, and with low rates of colistin- and tobramycin
      resistant colonization with nonsignificant increasing rate of ICU colonization
      resistance by 1000 days, adjusted by the rate of resistances at ICU admission. In
      addition, VAP and secondary BSI rates were significantly lower after SDD.
      Notably, a decrease in antimicrobial consumption was also observed.

PMID- 29843806
TI  - A computational framework for complex disease stratification from multiple large
      scale datasets.
AB  - BACKGROUND: Multilevel data integration is becoming a major area of research in
      systems biology. Within this area, multi-'omics datasets on complex diseases are
      becoming more readily available and there is a need to set standards and good
      practices for integrated analysis of biological, clinical and environmental data.
      We present a framework to plan and generate single and multi-'omics signatures of
      disease states. METHODS: The framework is divided into four major steps: dataset
      subsetting, feature filtering, 'omics-based clustering and biomarker
      identification. RESULTS: We illustrate the usefulness of this framework by
      identifying potential patient clusters based on integrated multi-'omics
      signatures in a publicly available ovarian cystadenocarcinoma dataset. The
      analysis generated a higher number of stable and clinically relevant clusters
      than previously reported, and enabled the generation of predictive models of
      patient outcomes. CONCLUSIONS: This framework will help health researchers plan
      and perform multi-'omics big data analyses to generate hypotheses and make sense
      of their rich, diverse and ever growing datasets, to enable implementation of
      translational P4 medicine.

PMID- 29843809
TI  - Validation of two scales for measuring participation and perceived stigma in
      Chinese community-based rehabilitation programs.
AB  - BACKGROUND: The World Health Organization has asserted the importance of
      enhancing participation of people with disabilities within the International
      Classification of Functioning, Disability and Health framework. Participation is
      regarded as a vital outcome in community-based rehabilitation. The actualization
      of the right to participate is limited by social stigma and discrimination. To
      date, there is no validated instrument for use in Chinese communities to measure
      participation restriction or self-perceived stigma. This study aimed to translate
      and validate the Participation Scale and the Explanatory Model Interview
      Catalogue (EMIC) Stigma Scale for use in Chinese communities with people with
      physical disabilities. METHODS: The Chinese versions of the Participation Scale
      and the EMIC stigma scale were administered to 264 adults with physical
      disabilities. The two scales were examined separately. The reliability analysis
      was studied in conjunction with the construct validity. Reliability analysis was
      conducted to assess the internal consistency and item-total correlation.
      Exploratory factor analysis was conducted to investigate the latent patterns of
      relationships among variables. A Rasch model analysis was conducted to test the
      dimensionality, internal validity, item hierarchy, and scoring category structure
      of the two scales. RESULTS: Both the Participation Scale and the EMIC stigma
      scale were confirmed to have good internal consistency and high item-total
      correlation. Exploratory factor analysis revealed the factor structure of the two
      scales, which demonstrated the fitting of a pattern of variables within the
      studied construct. The Participation Scale was found to be multidimensional,
      whereas the EMIC stigma scale was confirmed to be unidimensional. The item
      hierarchies of the Participation Scale and the EMIC stigma scale were discussed
      and were regarded as compatible with the cultural characteristics of Chinese
      communities. CONCLUSION: The Chinese versions of the Participation Scale and the
      EMIC stigma scale were thoroughly tested in this study to demonstrate their
      robustness and feasibility in measuring the participation restriction and
      perceived stigma of people with physical disabilities in Chinese communities.
      This is crucial as it provides valid measurements to enable comprehensive
      understanding and assessment of the participation and stigma among people with
      physical disabilities in Chinese communities.

PMID- 29843810
TI  - A new Aura virus isolate in Brazil shows segment duplication in the variable
      region of the nsP3 gene.
AB  - BACKGROUND: A new isolate of Aura virus serendipitously discovered as a cell
      culture contaminant is reported in this manuscript. Aura virus belongs to the
      family Togaviridae and is classified in the genus Alphavirus. There are only two
      reports of Aura virus isolation from mosquitoes in the scientific literature, and
      the existence of a vertebrate host is still unknown. The discovery of this new
      isolate was based on transmission electron microscopy and nucleic acid
      amplification through a non-specific RT-PCR amplification protocol followed by
      sequencing. RESULTS: Genetic analysis has shown that the new virus shares a high
      degree of identity with the previously described isolate (GenBank: AF126284.1). A
      major difference was observed in the nsP3 gene in which a 234-nucleotide
      duplication has been identified. Furthermore, a pronounced difference was
      observed in cell cultures compared to the data available for the previously
      described isolate. Cell permissiveness and phenotypic characteristics in C6/36,
      Vero and BHK-21 cells were found to differ from previous reports. This may be due
      to the genetic differences that have been observed. CONCLUSIONS: The genetic and
      biological characteristics of the new Aura virus isolate are suggestive of viral
      adaptation to the cell substrate. The development of a cDNA clone will lend a
      perspective and better understanding of these results as well as open avenues for
      its use as a biotechnological tool, as seen for other alphaviruses.

PMID- 29843811
TI  - First results on survival from a large Phase 3 clinical trial of an autologous
      dendritic cell vaccine in newly diagnosed glioblastoma.
AB  - BACKGROUND: Standard therapy for glioblastoma includes surgery, radiotherapy, and
      temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor
      lysate-pulsed dendritic cell vaccine (DCVax(r)-L) to standard therapy for newly
      diagnosed glioblastoma. METHODS: After surgery and chemoradiotherapy, patients
      were randomized (2:1) to receive temozolomide plus DCVax-L (n = 232) or
      temozolomide and placebo (n = 99). Following recurrence, all patients were
      allowed to receive DCVax-L, without unblinding. The primary endpoint was
      progression free survival (PFS); the secondary endpoint was overall survival
      (OS). RESULTS: For the intent-to-treat (ITT) population (n = 331), median OS
      (mOS) was 23.1 months from surgery. Because of the cross-over trial design,
      nearly 90% of the ITT population received DCVax-L. For patients with methylated
      MGMT (n = 131), mOS was 34.7 months from surgery, with a 3-year survival of
      46.4%. As of this analysis, 223 patients are >= 30 months past their surgery
      date; 67 of these (30.0%) have lived >= 30 months and have a Kaplan-Meier (KM)
      derived mOS of 46.5 months. 182 patients are >= 36 months past surgery; 44 of
      these (24.2%) have lived >= 36 months and have a KM-derived mOS of 88.2 months. A
      population of extended survivors (n = 100) with mOS of 40.5 months, not explained
      by known prognostic factors, will be analyzed further. Only 2.1% of ITT patients
      (n = 7) had a grade 3 or 4 adverse event that was deemed at least possibly
      related to the vaccine. Overall adverse events with DCVax were comparable to
      standard therapy alone. CONCLUSIONS: Addition of DCVax-L to standard therapy is
      feasible and safe in glioblastoma patients, and may extend survival. Trial
      registration Funded by Northwest Biotherapeutics; Clinicaltrials.gov number:
      NCT00045968;
      https://clinicaltrials.gov/ct2/show/NCT00045968?term=NCT00045968&rank=1 ;
      initially registered 19 September 2002.

PMID- 29843812
TI  - A cohort study on acute ocular motility disorders in pediatric emergency
      department.
AB  - BACKGROUND: Acute ocular motility disorders (OMDs) in children admitted to
      Emergency Department (ED) represents a not so rare condition with a wide spectrum
      of different etiologies. The emergency physician must be skilled in rapidly
      identifying patients with potentially life threatening (LT) forms, requiring
      further diagnostic procedures. The aim of the study was to assess characteristics
      of children with acute Ocular Motility Disorders (OMDs), and to identify "red
      flags" for recognition of underlying life-threatening (LT) conditions. METHODS: A
      retrospective cohort study evaluated children (2 months-17 years) admitted to a
      tertiary Emergency Department in 2009-2014. A subgroup analysis was performed
      comparing children with and without LT conditions. RESULTS: Of 192 visits for
      OMDs, the isolated strabismus occurred most frequently (55.6%), followed by pupil
      disorders (31.8%), ptosis (5.2%) and combined OMDs (11.5%). The majority of acute
      OMDs involved no underlying LT conditions (n = 136) and most of them were infants
      or toddlers (50%). In a multivariable analysis, LT conditions included especially
      children over 6 years of age, increasing the odds ratio by 2% for each months of
      age (p = 0.009). LT etiologies were 16 times more likely in combined OMDs (p =
      0.018), were over 13 times more likely to report associated extra-ocular
      signs/symptoms (p = 0.017) and over 50 times more likely to report co-morbidity
      (p = 0.017). CONCLUSION: OMDs are not an uncommon presentation at ED. Although
      most of them involve non-LT conditions, the ED physician should consider
      potential "red flags" for appropriate management of children such as age > 6
      years, combined OMDs, extra-ocular symptoms and co-morbidity.

PMID- 29843813
TI  - Stratification of ovarian tumor pathology by expression of programmed cell death
      1 (PD-1) and PD-ligand- 1 (PD-L1) in ovarian cancer.
AB  - BACKGROUND: Ovarian cancer is the major cause of death among gynecologic cancers
      with 75% of patients diagnosed with advanced disease, and only 20% of these
      patients having a survival duration of five years. Treatments blocking immune
      checkpoint molecules, programmed cell death (PD-1) or its ligand PD-ligand- I (PD
      L1) have produced a beneficial and prolonged effect in a subgroup of these
      patients. However, there is debate in the literature concerning the prognostic
      value of the expression of these molecules in tumors, with immunotherapy
      responsiveness, and survival. We evaluated the immune landscape of the ovarian
      tumor microenvironment of patients, by measuring the impact of the expression of
      tumor PD-1, PD-L1 and infiltrating lymphocytes on stage and grade of tumors and
      survival, in a cohort of 55 patients with gynecologic malignancies. Most patients
      under study were diagnosed with advanced disease ovarian cancer. RESULTS: Our
      studies revealed that a low density of PD-1 and of PD-L1 expressing cells in
      tumor tissue were significantly associated with advanced disease (P = 0.028 and P
      = 0.033, respectively). Moreover, PD-L1 was expressed significantly more often in
      high grade tumors (41.5%) than in low grade tumors of patients (7.7%) (P =
      0.040). The presence of CD3 or of FoxP3 infiltrating cells with PD-L1 in patient
      tumors did not impact the significance of the association of PD-L1 with high
      grade tumors (P = 0.040), and our analyses did not show an association between
      the presence of PD-1 or PD-L1 and survival. CONCLUSIONS: We conclude that a
      subgroup of advanced disease ovarian cancer patients with high grade tumors,
      expressing PD-L1, may be prime candidates for immunotherapy targeting PD-1
      signaling.

PMID- 29843815
TI  - Re-exploring the value of surveillance cultures in predicting pathogens of late
      onset neonatal sepsis in a tertiary care hospital in southern Sri Lanka.
AB  - OBJECTIVE: To identify the validity of surveillance cultures in predicting
      causative organism(s) of late onset neonatal sepsis. RESULTS: Prospective
      analytical study was conducted from January to April 2011 at the Neonatal
      Intensive Care Unit, Teaching Hospital, Karapitiya, Galle, Sri Lanka. Fifty
      neonates were screened on admission and weekly thereafter for colonization with
      potential pathogens. On suspicion of infection, relevant samples were cultured
      and tested for antibiotic sensitivity. There were 55 episodes of clinically
      suspected infections including 33 nosocomial infections. One-third (17/55) of all
      clinically suspected infections were culture positive. Out of 55, only 33
      episodes were clinically suspected nosocomial infections. Clinically suspected
      nosocomial infection rate was 50/1000 patient-days. Culture proven nosocomial
      infection rate was 13.61/1000 patient-days. Coliforms were the commonest clinical
      isolate (76%) and 2/3 of them produced extended spectrum beta lactamase. More
      than 80% of the isolates causing late onset sepsis were sensitive to carbapenems
      and aminoglycosides. Sensitivity, specificity, positive predictive value and
      negative predictive value of surveillance cultures were 77.8, 37.5, 31.8 and
      81.8%, respectively. Surveillance samples can be used to predict pathogens of
      late-onset sepsis. Broad-spectrum antibiotics (carbapenems, aminoglycosides) are
      recommended as empirical therapy for late-onset neonatal sepsis.

PMID- 29843814
TI  - 'It's because I like things... it's a status and he buys me airtime': exploring
      the role of transactional sex in young women's consumption patterns in rural
      South Africa (secondary findings from HPTN 068).
AB  - BACKGROUND: 'Transactional sex', defined as a non-marital, non-commercial sexual
      relationship in which money or material goods are exchanged for sex, is
      associated with young women's increased vulnerability to HIV infection. Existing
      research illustrates that the motivations for transactional sex are complex. The
      fulfilment of psycho-social needs such as the need to belong to a peer group are
      important factors underlying young women's desires to obtain certain consumption
      items and thus engage in transactional sex. METHODS: We use a mixed-methods
      approach to explore the relationship between transactional sex and consumption
      patterns among young women in rural Mpumalanga province, South Africa. In the
      secondary analysis of 693 sexually active young women, we use factor analysis to
      group the different consumption items and we use multivariable logistic
      regression to demonstrate the relationship between transactional sex and
      consumption patterns. The qualitative study uses five focus group discussions and
      19 in-depth interviews to explore further young women's motivations for acquiring
      different consumption items. RESULTS: The quantitative results show that young
      women that engage in transactional sex have higher odds of consuming items for
      entertainment (e.g., movie tickets) than on practical items (e.g., food and
      groceries). The qualitative findings also revealed that young women's perceptions
      of items that were considered a 'need' were strongly influenced by peer pressure
      and a desire for improved status. Further, there was a perception that emerged
      from the qualitative data that relationships with sugar daddies offered a way to
      acquire consumer goods associated with a 'modern lifestyle', such as items for
      personal enhancement and entertainment. However, young women seem aware of the
      risks associated with such relationships. More importantly, they also develop
      relationship with partners of similar age, albeit with the continued expectation
      of material exchange, despite engaging in the relationship for love. CONCLUSION:
      This study shows that young women are willing to take certain risks in order to
      have a degree of financial independence. Interventions that provide alternative
      methods of attaining this independence, such as the provision of cash transfers
      may have potential in preventing them from engaging in transactional
      relationships. Further, the psycho-social reasons that drive young women's
      motivations for consumption items resulting in risky sexual behaviours need to be
      better understood.

PMID- 29843816
TI  - Response to flutamide, as second-line therapy after bicalutamide, predicts
      efficacy of abiraterone, not that of enzalutamide.
AB  - OBJECTIVE: The objective of this retrospective study was to evaluate whether the
      effect of second-line therapy of flutamide after bicalutamide can predict the
      response to abiraterone. RESULTS: Thirty-four patients received abiraterone and
      32 received enzalutamide after treatment with second-line flutamide for
      castration-resistant prostate cancer. Prostate-specific antigen-progression-free
      survival during treatment with abiraterone or enzalutamide was the endpoint. The
      response to flutamide therapy was defined as any decrease in prostate-specific
      antigen compared to baseline prostate-specific antigen. Among the abiraterone
      treated patients, those for whom flutamide after bicalutamide was effective
      showed significantly lower prostate-specific antigen changes than those for whom
      it was ineffective (P = 0.0175). Prostate-specific antigen-progression-free
      survival was significantly higher in the abiraterone patients when flutamide was
      effective than in the patients when it was ineffective (P = 0.027). However, in
      enzalutamide-treated patients, the prostate-specific antigen changes were not
      significantly different between those for whom flutamide after bicalutamide was
      effective and those for whom it was ineffective (P = 0.75). In the enzalutamide
      patients, prostate-specific antigen-progression-free survival was not
      significantly different between those for whom flutamide was effective and those
      for whom it was ineffective (P = 0.92). Therefore, the response to second-line
      flutamide predicts the efficacy of abiraterone. This information should be
      helpful when choosing between abiraterone and enzalutamide for patients with
      castration-resistant prostate cancer.

PMID- 29843817
TI  - BGP: identifying gene-specific branching dynamics from single-cell data with a
      branching Gaussian process.
AB  - High-throughput single-cell gene expression experiments can be used to uncover
      branching dynamics in cell populations undergoing differentiation through
      pseudotime methods. We develop the branching Gaussian process (BGP), a non
      parametric model that is able to identify branching dynamics for individual genes
      and provide an estimate of branching times for each gene with an associated
      credible region. We demonstrate the effectiveness of our method on simulated
      data, a single-cell RNA-seq haematopoiesis study and mouse embryonic stem cells
      generated using droplet barcoding. The method is robust to high levels of
      technical variation and dropout, which are common in single-cell data.

PMID- 29843818
TI  - Sex and cardiovascular disease status differences in attitudes and willingness to
      participate in clinical research studies/clinical trials.
AB  - BACKGROUND: While women are under-represented in research on cardiovascular
      disease (CVD), little is known about the attitudes of men and women with CVD
      regarding participation in clinical research studies/clinical trials. METHODS:
      Patients with CVD (and/or risk factors) and patients with other chronic
      conditions from Iowa were recruited from a commercial panel. An on-line survey
      assessed willingness to participate (WTP) and other attitudes towards aspects of
      clinical research studies. RESULTS: Based on 504 respondents, there were no
      differences in WTP in patients with CVD compared to patients with other chronic
      diseases. Across all respondents, men had 14% lower WTP (relative risk (RR) for
      men, 0.86, 95% CI, 0.72-1.02). Among patients with CVD, there was no significant
      difference in WTP between women (RR for women = 1) and men (RR for men, 0.96, 95%
      CI, 0.82-1.14). There were no significant differences based on sex or CVD status
      for attitudes on randomization, blinding, side effects, conflict of interest,
      experimental treatments or willingness to talk to one's physician. Women had more
      favorable attitudes about participants being treated like "guinea pigs" (RR for
      men, 0.84, 95% CI, 0.73-0.98) and clinical trials being associated with
      terminally ill patients (RR for men, 0.93, 95% CI, 0.86-1.00). CONCLUSIONS: The
      findings reported here suggest that the observed lower levels of participation by
      women are due to factors other than a lower WTP or to women having more negative
      attitudes towards aspects of study participation. Patients with CVD have similar
      attitudes and WTP as patients with other chronic conditions.

PMID- 29843819
TI  - The effect of lipopolysaccharide on the expression level of immunomodulatory and
      immunostimulatory factors of human amniotic epithelial cells.
AB  - OBJECTIVE: Human amniotic epithelial cells (hAECs) are a novel source of stem
      cells and have immunomodulatory effects on both the innate and adoptive immune
      system. hAECs can differentiate into multiple cell lineages that make them a
      suitable cell source for regenerative medicine. These cells express multiple toll
      like receptors (TLRs) and respond to various TLR ligands. This study aimed to
      evaluate the effect of lipopolysaccharide (LPS), a TLR4 ligand, on the level of
      immunomodulatory and immunostimulatory factors of hAECs. RESULTS: Our results
      indicated that LPS had the ability to up-regulate the expression of prostaglandin
      E2 synthase and transforming growth factor-beta1 in hAECs. However, there was no
      change in the level of interleukin-1beta, interleukin-6 and interleukin-10 in
      hAECs when were stimulated with LPS. In addition, we observed tumor necrosis
      factor-alpha was only expressed at very low level in some of hAECs samples which
      its expression was independent of the effects of LPS.

PMID- 29843820
TI  - Successful treatment of primary bone marrow Hodgkin lymphoma with brentuximab
      vedotin: a case report and review of the literature.
AB  - BACKGROUND: Hodgkin lymphoma usually presents with sequential enlargement of
      peripheral lymph nodes, and bone marrow invasion rarely occurs (approximately 3
      5%). However, several cases have been reported as "primary" bone marrow Hodgkin
      lymphoma, especially among patients with human immunodeficiency virus and the
      elderly. This type of Hodgkin lymphoma is characterized by no peripheral
      lymphadenopathies and has been reported to have poorer prognosis. CASE
      PRESENTATION: A 38-year-old Japanese man was admitted to our hospital because of
      fever of unknown origin and pancytopenia without lymphadenopathies. Bone marrow
      examination revealed Hodgkin cells mimicking abnormal cells. These were positive
      for CD30, EBER-1, CD15, PAX-5, and Bob-1 and negative for Oct-2, CD3, CD20,
      surface immunoglobulin, CD56. On the basis of systemic evaluation and bone marrow
      examination, he was diagnosed with primary bone marrow Hodgkin lymphoma. We
      initiated therapy with DeVIC (dexamethasone, etoposide, ifosfamide, and
      carboplatin) therapy, but remission was not achieved. Then, the patient was
      treated with brentuximab vedotin combined with systemic chemotherapy (Adriamycin,
      vinblastine and dacarbazine), which was effective. CONCLUSIONS: There is no
      established treatment strategy for Hodgkin lymphoma, and therapeutic outcomes
      using ABVD (Adriamycin, bleomycin, vinblastine and dacarbazine)-like or CHOP
      (cyclophosphamide, Adriamycin, vincristine, and prednisone)-like regimens are
      reportedly poor. Only a few patients have been reported to achieve long-term
      remission. Through this case report, we suggest an alternative therapeutic option
      for primary bone marrow Hodgkin lymphoma.

PMID- 29843821
TI  - On-orbit sleep problems of astronauts and countermeasures.
AB  - Sufficient sleep duration and good sleep quality are crucial to ensure normal
      physical and mental health, cognition and work performance for the common people,
      as well as astronauts. On-orbit sleep problem is very common among astronauts and
      has potential detrimental influences on the health of crewmembers and the safety
      of flight missions. Sleep in space is becoming a new medical research frontier.
      In this review we summarized on-orbit sleep problems of astronauts and six kinds
      of causes, and we presented the effects of lack of sleep on performance as well
      as mental and physical health, then we proposed seven kinds of countermeasures
      for sleep disturbance in spaceflight, including pharmacologic interventions,
      light treatment, crew selection and training, Traditional Chinese Medicine and so
      on. Furthermore, we discussed and oriented the prospect of researches on sleep in
      space.

PMID- 29843822
TI  - Co-transfer of tumor-specific effector and memory CD8+ T cells enhances the
      efficacy of adoptive melanoma immunotherapy in a mouse model.
AB  - BACKGROUND: Adoptive cell transfer (ACT) is a promising cancer immunotherapeutic
      strategy that remains ineffective for a large subset of patients. ACT with memory
      CD8+ T cells (Tmem) has been shown to have superior efficacy compared to
      traditional ACT with effector CD8+ T cells (Teff). Teff and Tmem have
      complementary physiological advantages for immunotherapy, but previous
      publications have not examined ACT using a combination of Teff and Tmem. METHODS:
      Splenocytes harvested from Ly5.1+/C57BL/6 mice during and after infection with
      lymphocytic choriomeningitis virus (LCMV) were used to generate bona fide
      effector and memory CD8+ T cells specific for the LCMV epitope peptide GP33.
      Congenic Ly5.2+/C57BL/6 mice were inoculated with B16F10 melanoma cells
      transfected to express very low levels of GP33, then treated with ACT 7 days
      later with GP33-specific Teff, Tmem, or a combination of Teff + Tmem. RESULTS:
      Inhibition of melanoma growth was strongest in mice receiving combinatorial ACT.
      Although combinatorial ACT and memory ACT resulted in maximal intratumoral
      infiltration of CD8+ T cells, combinatorial ACT induced stronger infiltration of
      endogenous CD8+ T cells than Tmem ACT and a stronger systemic T cell
      responsiveness to tumor antigen. In vitro assays revealed rapid but transient
      melanoma inhibition with Teff and gradual but prolonged melanoma inhibition with
      Tmem; the addition of Tmem enhanced the ability of Teff to inhibit melanoma in a
      manner that could be reproduced using conditioned media from activated Tmem and
      blocked by the addition of anti-IL-2 blocking antibody. CONCLUSIONS: These
      findings suggest that a novel combinatorial approach that takes advantage of the
      unique and complementary strengths of tumor-specific Teff and Tmem may be a way
      to optimize the efficacy of adoptive immunotherapy.

PMID- 29843823
TI  - A novel canine model for Duchenne muscular dystrophy (DMD): single nucleotide
      deletion in DMD gene exon 20.
AB  - BACKGROUND: Boys with Duchenne muscular dystrophy (DMD) have DMD gene mutations,
      with associated loss of the dystrophin protein and progressive muscle
      degeneration and weakness. Corticosteroids and palliative support are currently
      the best treatment options. The long-term benefits of recently approved compounds
      such as eteplirsen and ataluren remain to be seen. Dogs with naturally occurring
      dystrophinopathies show progressive disease akin to that of DMD. Accordingly,
      canine DMD models are useful for studies of pathogenesis and preclinical therapy
      development. A dystrophin-deficient, male border collie dog was evaluated at the
      age of 5 months for progressive muscle weakness and dysphagia. CASE PRESENTATION:
      Dramatically increased serum creatine kinase levels (41,520 U/L; normal range 59
      895 U/L) were seen on a biochemistry panel. Histopathologic changes
      characteristic of dystrophinopathy were seen. Dystrophin was absent in the
      skeletal muscle on immunofluorescence microscopy and western blot. Whole genome
      sequencing, polymerase chain reaction, and Sanger sequencing revealed a
      frameshift, single nucleotide deletion in canine DMD exon 20, position 27,626,466
      (c.2841delT mRNA), resulting in a stop codon six nucleotides downstream. Semen
      was archived for future line perpetuation. CONCLUSIONS: This spontaneous canine
      dystrophinopathy occurred due to a novel mutation in the minor DMD mutation
      hotspot (between exons 2 through 20). Perpetuating this line could allow for
      preclinical testing of genetic therapies targeted to this area of the DMD gene.

PMID- 29843824
TI  - The risk of urban yellow fever resurgence in Aedes-infested American cities.
AB  - Aedes aegypti, historically known as yellow fever (YF) mosquito, transmits a
      great number of other viruses such as Dengue, West Nile, Chikungunya, Zika,
      Mayaro and perhaps Oropouche, among others. Well established in Africa and Asia,
      Aedes mosquitoes are now increasingly invading large parts of the American
      continent, and hence the risk of urban YF resurgence in the American cities
      should because of great concern to public health authorities. Although no new
      urban cycle of YF was reported in the Americas since the end of an Aedes
      eradication programme in the late 1950s, the high number of non-vaccinated
      individuals that visit endemic areas, that is, South American jungles where the
      sylvatic cycle of YF is transmitted by canopy mosquitoes, and return to Aedes
      infested urban areas, increases the risk of resurgence of the urban cycle of YF.
      We present a method to estimate the risk of urban YF resurgence in dengue-endemic
      cities. This method consists in (1) to estimate the number of Aedes mosquitoes
      that explains a given dengue outbreak in a given region; (2) calculate the force
      of infection caused by the introduction of one infective individual per unit area
      in the endemic area under study; (3) using the above estimates, calculate the
      probability of at least one autochthonous YF case per unit area produced by one
      single viraemic traveller per unit area arriving from a YF endemic or epidemic
      sylvatic region at the city studied. We demonstrate that, provided the relative
      vector competence, here defined as the capacity to being infected and disseminate
      the virus, of Ae. aegypti is greater than 0.7 (with respect to dengue), one
      infected traveller can introduce urban YF in a dengue endemic area.

PMID- 29843825
TI  - Association of influenza outbreaks with advanced pediatric medical support.
AB  - Retrospective data evaluated increases in advanced medical support for children
      with medically attended acute respiratory illness (MAARI) during influenza
      outbreak periods (IOP). Advanced support included hospitalisation, intensive care
      unit admission, or mechanical ventilation, for children aged 0-17 years
      hospitalised in Maryland's 50 acute-care hospitals over 12 influenza seasons.
      Weekly numbers of positive influenza tests in the Maryland area defined IOP for
      each season as the fewest consecutive weeks, including the peak week containing
      at least 85% of positive tests with a 2-week buffer on either side of the IOP.
      Peak IOP (PIOP) was defined as four consecutive weeks containing the peak week
      with the most number of positive influenza tests. Off-PIOP was defined as the
      'shoulder' weeks during each IOP. Non-influenza season (NIS) was the remaining
      weeks of that study season. Rate ratios of mean daily MAARI-related admissions
      resulting in advanced medical support outcomes during PIOP or Off-PIOP were
      compared with the NIS and were significantly elevated for all 12 study seasons
      combined. The results suggest that influenza outbreaks are associated with
      increased advanced medical support utilisation by children with MAARI. We feel
      that this data may help preparedness for severe influenza epidemics or pandemic.

PMID- 29843826
TI  - Reinfection hazard of hand-foot-mouth disease in Wuhan, China, using Cox
      proportional hazard model.
AB  - Hand-foot-mouth disease (HFMD) is an acute infectious disease caused by serotypes
      of the enterovirus (EV) family. HFMD reinfection occurs commonly in lack of cross
      protection between different EV serotypes. In this study, we investigated the
      hazards of HFMD reinfection using Cox-proportional hazard model. Retrospective
      data of 95 209 HFMD cases in Wuhan during 2008-2015 was used. Kaplan-Meier
      survival methods and Cox-proportional hazard model were used to estimate the
      hazard probabilities. Of the all HFMD cases, about 2% experienced reinfection
      (1842/95 209). Kaplan-Meier curves revealed the reinfection risk sharply
      increased before 40 months from first infection. Higher hazards of reinfection
      were detected among those who were males, aged 3 years and below, scattered
      children, belonging to urban areas and first infected with coxsackievirus (CV)
      A16 compared with their respective counterparts. Cox-proportional hazard model
      suggested that gender, age, group, living area and serotypes of first infection
      had significant effect on reinfection even after adjusting for potential
      confounding effects of other selected factors considered in the study. These
      results indicate that boys aged 3 years and below, especially those living in
      urban areas and first infected with CV-A16 are more prone to reinfection.
      Interventions should be imposed on these high-risk populations.

PMID- 29843827
TI  - Serological survey on Leptospira infection in slaughtered swine in North-Central
      Italy.
AB  - Swine can act as asymptomatic carriers of some Leptospira serovars. In this
      study, 1194 sera from 61 farms located in five different Regions of North-West
      Italy were collected from slaughtered healthy pigs. Presence of antibody against
      four Leptospira serovars was evaluated. Overall, 52.5% of analysed farms
      presented at least one positive animal and 34.4% presented at least one positive
      swine with titre ?1:400. A percentage of 16.6% sera was positive and 5.9% samples
      presented a positive titre ?1:400. Tuscany and Lombardy showed the highest
      percentage of positive farms (64.3% and 54.6%, respectively) and sera (28.5% and
      13.3%, respectively), probably due to environmental conditions and potential risk
      factors, which promote maintenance and spreading of Leptospira in these areas.
      The main represented serogroups were Australis (21.3% positive farms, 8.2%
      positive sera) and Pomona (18.0% positive farms, 8.1% positive sera). In swine,
      these serogroups are the most detected worldwide; however, our results seem to
      highlight a reemerging of serogroup Pomona in pigs in investigated areas. A low
      percentage of sera (0.6%) scored positive to Canicola, leaving an open question
      on the role of pigs in the epidemiology of this serovar. Higher antibody titres
      were detected for serogroups Australis and Pomona. Swine leptospirosis is
      probably underestimated in Italy and could represent a potential risk for animal
      and human health.

PMID- 29843828
TI  - Assessment of Executive Functions in Preschool Children With Sickle Cell Anemia.
AB  - OBJECTIVES: Children with sickle cell anemia (SCA) are commonly reported to
      experience executive dysfunction. However, the development of executive function
      (EF) in preschool-age children without stroke in this patient population has not
      been investigated so it is unclear when and how these deficits emerge. METHODS:
      This case-control study examines the feasibility of assessing the early
      development of executive functioning in 22 preschool children years with SCA in
      the domains of processing speed, working memory, attention, inhibitory control,
      and cognitive flexibility, as well as everyday function, in comparison to matched
      control children. RESULTS: A pattern of potential deficits in early emerging
      executive skills was observed in the domains of inhibitory control and cognitive
      flexibility. Parents reported no differences for everyday EF and no significant
      differences were observed for working memory and processing speed. CONCLUSIONS:
      Results suggest that deficits in everyday executive difficulties, working memory,
      and processing speed, as commonly reported for older children with SCA, may not
      yet have emerged at this early developmental stage, despite specific deficits in
      cognitive flexibility and inhibitory control on behavioral measures. The
      feasibility of using available executive measures with preschool age children to
      characterize the development of early EF skills is discussed. (JINS, 2018, 24,
      949-954).

PMID- 29843829
TI  - The validity of mid-upper arm circumference as an indicator of low BMI in
      population screening for undernutrition: a study among adult slum dwellers in
      eastern India.
AB  - OBJECTIVE: To explore the possibility for a statistically appropriate value of
      mid-upper arm circumference (MUAC) to identify the state of severe
      undernutrition, based on very low BMI, among adult Indian slum dwellers. DESIGN:
      Cross-sectional study on adults. Height and MUAC were recorded and BMI was
      computed. Chronic energy deficiency (CED) was determined using the WHO
      international guidelines as BMI<18.5 kg/m2 and normal as BMI>=18.5 kg/m2. Besides
      calculating mean, sd and 25th, 50th and 75th percentile values, multiple linear
      regression analysis was undertaken to assess the associations between age, MUAC
      and BMI. Receiver-operating characteristic curve analysis was performed to
      determine the best MUAC cut-off to identify CED status. The chi 2 test was used
      to assess significance of the difference in CED prevalence across MUAC
      categories. SETTING: An urban slum in Midnapore town, West Bengal State, India.
      SUBJECTS: Male (n 467) and female (n 488) Indian slum dwellers. RESULTS: MUAC of
      22.7 and 21.9 cm, respectively, in males and females were the best cut-off points
      to differentiate CED from non-CED. CONCLUSIONS: Results supported the validity of
      the WHO-recommended MUAC cut-offs for adults. There is still a need to establish
      statistically appropriate MUAC cut-offs to predict undernutrition and morbidity.

PMID- 29843830
TI  - Applying the zero-inflated Poisson model with random effects to detect abnormal
      rises in school absenteeism indicating infectious diseases outbreak.
AB  - Records of absenteeism from primary schools are valuable data for infectious
      diseases surveillance. However, the analysis of the absenteeism is complicated by
      the data features of clustering at zero, non-independence and overdispersion.
      This study aimed to generate an appropriate model to handle the absenteeism data
      collected in a European Commission granted project for infectious disease
      surveillance in rural China and to evaluate the validity and timeliness of the
      resulting model for early warnings of infectious disease outbreak. Four steps
      were taken: (1) building a 'well-fitting' model by the zero-inflated Poisson
      model with random effects (ZIP-RE) using the absenteeism data from the first
      implementation year; (2) applying the resulting model to predict the 'expected'
      number of absenteeism events in the second implementation year; (3) computing the
      differences between the observations and the expected values (O-E values) to
      generate an alternative series of data; (4) evaluating the early warning validity
      and timeliness of the observational data and model-based O-E values via the EARS
      3C algorithms with regard to the detection of real cluster events. The results
      indicate that ZIP-RE and its corresponding O-E values could improve the detection
      of aberrations, reduce the false-positive signals and are applicable to the zero
      inflated data.

PMID- 29843831
TI  - Burden of Frailty in Post-Disaster Low-Income Countries: An Example From Nepal.

PMID- 29843832
TI  - Maternal vitamin D concentrations are associated with faster childhood reaction
      time and response speed, but not with motor fluency and flexibility, at the age
      of 5-6 years: the Amsterdam Born Children and their Development (ABCD) Study.
AB  - About 57 % of the pregnant European women have 25-hydroxyvitamin D (25(OH)D)
      concentrations below 50 nmol/l. However, as data on the impact of gestational
      vitamin D deficiency on maternal and fetal health are limited, the WHO does not
      advocate vitamin D supplementation as part of routine antenatal care. We explored
      associations between first trimester maternal 25(OH)D status and childhood
      cognition at 5-6 years of age (n 1854, primarily Caucasian). Median serum 25(OH)D
      was determined at 13 (interquartile range 12-14) weeks of gestation. Childhood
      attention, motor fluency and flexibility and executive function were assessed
      using the Amsterdam Neuropsychological Tasks. Restricted cubic splines and linear
      regression analyses were used to analyse the data while adjusting for many
      maternal and child related covariates. Higher 25(OH)D status (nmol/l) was
      associated with better attention and executive functioning as shown by a faster
      reaction time (beta -0.30 (sd 0.14) ms, P=0.03), faster response speed (beta 
      0.58 (sd 0.21) ms, P=0.006), and better response speed stability (beta -0.45 (sd
      0.17) ms, P=0.009). No associations were observed of serum 25(OH)D with motor
      fluency and flexibility. Associations were most pronounced among children of
      African origin (n 205) as compared with those of Caucasian or another origin, for
      example attention (reaction time, beta -2.06 (sd 0.70) ms, P=0.004) and executive
      function (response speed, beta -1.95 (sd 0.94) ms, P=0.04). Concluding, maternal
      25(OH)D status was significantly associated with childhood attention and
      executive function, while no associations were observed for 25(OH)D status with
      motor fluency and flexibility.

PMID- 29843833
TI  - Effects of chito-oligosaccharide on piglet jejunal explants: an histological
      approach.
AB  - Antibiotics have been widely used in piglet diets to promote growth performance
      and reduce diarrhea incidence. However, the resistance of pathogens to
      antibiotics and the risk of residues of antibiotics in animal products induced a
      growing interest in the use of alternatives to in-feed antibiotics. Chito
      oligosaccharide (COS), a natural alkaline polymer of glucosamine is currently
      being tested as a substitute for in-feed antibiotics. In weaned piglets, COS has
      positive effects on promoting growth, which may be related to its action on
      intestinal morphology, immune ability and beneficial microbiota. However,
      previous studies shown variable results with effective doses ranging from 30
      mg/kg to 5 g/kg. Therefore, the goal of this study was to test the hypothesis
      that the use of COS can be an alternative to in-feed antibiotics by improve the
      intestinal morphology of piglets, using the jejunal explant model. The intestinal
      explants were exposed for 4 h to following treatments: control - only culture
      media and culture media with COS in doses of 0.025 mg/ml, 0.05 mg/ml, 0.1 mg/ml
      and 0.15 mg/ml. After the incubation period the explants were processed for
      histological and morphometrical analysis. The histological changes were evaluated
      using an adapted histological score based on the intensity and severity of
      lesions. Mild histological changes were observed in jejunal explants exposed to
      different treatments; however, no significant difference in the histological
      score, villi height, crypt depth or villus : crypt ratio were observed between
      the COS-groups and the control. In addition, goblet cells density in intestinal
      explants exposed to COS remained statistically similar to control group. Our
      results indicate that COS exposure in levels ranging from 0.025 to 0.15 mg/ml
      induced no effect on intestinal morphology of pig's explants. The research will
      provide guidance on the low dosage of COS supplementation on weaning pigs.

PMID- 29843834
TI  - Molecular detection of Anaplasma phagocytophilum DNA in the lesser horseshoe bat
      (Rhinolophus hipposideros) guano.
AB  - Although bats are increasingly recognised as potential reservoir hosts of human
      zoonotic pathogens, bacteria in bats are still poorly studied. To investigate the
      DNA faecal prevalence of the bacterium Anaplasma phagocytophilum, we sampled 23
      lesser horseshoe bat (Rhinolophus hipposideros) maternity colonies located in
      buildings (churches, barns) in rural villages of eastern France. A total of 552
      faecal samples were collected from 278 individuals. Anaplasma phagocytophilum DNA
      was detected in the faeces of 63 individuals (22.7%). Such high prevalence might
      suggest persistent infection in bats and/or a frequent consumption of insect
      preys carrying bacteria. Faecal DNA prevalence varied highly among colonies but
      was not related to the colony size. Faecal DNA prevalence was the highest in the
      Jura Department, where the density of ticks is known to be the highest across the
      study area. Because the sampled bats live in close proximity to humans, we
      discuss how concerning the presence of A. phagocytophilum DNA in bat guano is for
      humans frequenting places of worship that shelter bats. We also advocate future
      research to understand what a high faecal DNA prevalence in bat guano really
      implicates in terms of bacteria transmission.

PMID- 29843835
TI  - Positive predictive value of infective endocarditis in the Danish National
      Patient Registry: a validation study.
AB  - The positive predictive value of an infective endocarditis diagnosis is
      approximately 80% in the Danish National Patient Registry. However, since
      infective endocarditis is a heterogeneous disease implying long-term intravenous
      treatment, we hypothesiszed that the positive predictive value varies by length
      of hospital stay. A total of 100 patients with first-time infective endocarditis
      in the Danish National Patient Registry were identified from January 2010 -
      December 2012 at the University hospital of Aarhus and regional hospitals of
      Herning and Randers. Medical records were reviewed. We calculated the positive
      predictive value according to admission length, and separately for patients with
      a cardiac implantable electronic device and a prosthetic heart valve using the
      Wilson score method. Among the 92 medical records available for review, the
      majority of the patients had admission length ?2 weeks. The positive predictive
      value increased with length of admission. In patients with admission length <2
      weeks the positive predictive value was 65% while it was 90% for admission length
      ?2 weeks. The positive predictive value was 81% for patients with a cardiac
      implantable electronic device and 87% for patients with a prosthetic valve. The
      positive predictive value of the infective endocarditis diagnosis in the Danish
      National Patient Registry is high for patients with admission length ?2 weeks.
      Using this algorithm, the Danish National Patient Registry provides a valid
      source for identifying infective endocarditis for research.

PMID- 29843836
TI  - Economic Community of West African States Disaster Preparedness Tabletop
      Exercise: Building Regional Capacity to Enhance Health Security.
AB  - OBJECTIVE: The West African Disaster Preparedness Initiative held a disaster
      preparedness tabletop exercise with representatives from the Economic Community
      of West African States (ECOWAS) in November 2015. The tabletop exercise was
      hosted by the Republic of Ghana's National Disaster Management Organization and
      partners in Accra, Ghana. METHODS: ECOWAS Commission delegates and
      representatives from 10 member states were confronted with a series of simulated
      crises. Participants utilized existing national preparedness plans and web-based
      information technologies to research and communicate about internal disaster
      threats and those from neighboring countries. After each of the exercise's three
      phases, facilitators distributed participant surveys. RESULTS: A total of 106
      individuals participated in the tabletop exercise. During the exercise, national
      teams utilizing well-developed disaster contingency plans and emergency
      operations center (EOC) standard operating procedures (SOPs) reached out to help
      less-prepared national teams. Key issues identified in the survey were language
      and cultural issues as barriers, effectiveness of disaster management agencies
      linked to heads of state, and the need for data sharing and real-time
      communication for situational awareness and multisector coordination. CONCLUSION:
      This tabletop exercise helped improve and refine the ECOWAS regional and member
      states' national SOPs that teams will employ to prepare for, respond to, and
      recover from future disasters. (Disaster Med Public Health Preparedness.
      2018;page 1 of 5).

PMID- 29843837
TI  - Application of quality improvement analytic methodology in emergency medicine
      research: A comparative evaluation.
AB  - OBJECTIVE: Quality improvement (QI) analytic methodology is rarely encountered in
      the emergency medicine literature. We sought to comparatively apply QI design and
      analysis techniques to an existing data set, and discuss these techniques as an
      alternative to standard research methodology for evaluating a change in a process
      of care. METHODS: We used data from a previously published randomized controlled
      trial on triage-nurse initiated radiography using the Ottawa ankle rules (OAR).
      QI analytic tools were applied to the data set from this study and evaluated
      comparatively against the original standard research methodology. RESULTS: The
      original study concluded that triage nurse-initiated radiographs led to a
      statistically significant decrease in mean emergency department length of stay.
      Using QI analytic methodology, we applied control charts and interpreted the
      results using established methods that preserved the time sequence of the data.
      This analysis found a compelling signal of a positive treatment effect that would
      have been identified after the enrolment of 58% of the original study sample, and
      in the 6th month of this 11-month study. CONCLUSIONS: Our comparative analysis
      demonstrates some of the potential benefits of QI analytic methodology. We found
      that had this approach been used in the original study, insights regarding the
      benefits of nurse-initiated radiography using the OAR would have been achieved
      earlier, and thus potentially at a lower cost. In situations where the
      overarching aim is to accelerate implementation of practice improvement to
      benefit future patients, we believe that increased consideration should be given
      to the use of QI analytic methodology.

PMID- 29843838
TI  - Trends in proportion of older HIV-infected people in care in Latin America and
      the Caribbean: a growing challenge.
AB  - We aimed to quantify the proportion of people receiving care for HIV-infection
      that are 50 years or older (older HIV patients) in Latin America and the
      Caribbean between 2000 and 2015 and to estimate the contribution to the growth of
      this population of people enrolled before (<50yo) and after 50 years old (yo)
      (?50yo). We used a series of repeated, cross-sectional measurements over time in
      the Caribbean, Central and South American network (CCASAnet) cohort. We estimated
      the percentage of patients retained in care each year that were older HIV
      patients. For every calendar year, we divided patients into two groups: those who
      enrolled before age 50 and after age 50. We used logistic regression models to
      estimate the change in the proportion of older HIV patients between 2000 and
      2015. The percentage of CCASAnet HIV patients over 50 years had a threefold
      increase (8% to 24%) between 2000 and 2015. Most of the growth of this population
      can be explained by the increasing proportion of people that enrolled before 50
      years and aged in care. These changes will impact needs of care for people living
      with HIV, due to multiple comorbidities and high risk of disability associated
      with aging.

PMID- 29843839
TI  - Posterior Cerebellar Volume and Executive Function in Young Adults With
      Congenital Heart Disease.
AB  - OBJECTIVES: As the number of adolescents and young adults (AYAs) surviving
      congenital heart disease (CHD) grows, studies of long-term outcomes are needed.
      CHD research documents poor executive function (EF) and cerebellum (CB)
      abnormalities in children. We examined whether AYAs with CHD exhibit reduced EF
      and CB volumes. We hypothesized a double dissociation such that the posterior CB
      is related to EF while the anterior CB is related to motor function. We also
      investigated whether the CB contributes to EF above and beyond processing speed.
      METHODS: Twenty-two AYAs with CHD and 22 matched healthy controls underwent
      magnetic resonance imaging and assessment of EF, processing speed, and motor
      function. Volumetric data were calculated using a cerebellar atlas (SUIT)
      developed for SPM. Group differences were compared with t tests, relationships
      were tested with Pearson's correlations and Fisher's r to z transformation, and
      hierarchical regression was used to test the CB's unique contributions to EF.
      RESULTS: CHD patients had reduced CB total, lobular, and white matter volume
      (d=.52-.99) and poorer EF (d=.79-1.01) compared to controls. Significant
      correlations between the posterior CB and EF (r=.29-.48) were identified but
      there were no relationships between the anterior CB and motor function nor EF.
      The posterior CB predicted EF above and beyond processing speed (ps<.001).
      CONCLUSIONS: This study identified a relationship between the posterior CB and
      EF, which appears to be particularly important for inhibitory processes and
      abstract reasoning. The unique CB contribution to EF above and beyond processing
      speed alone warrants further study. (JINS, 2018, 24, 939-948).

PMID- 29843840
TI  - Understanding why older adults choose to seek non-urgent care in the emergency
      department: the patient's perspective.
AB  - CLINICIAN'S CAPSULE What is known about the topic? While EDs serve a critical
      role in the care of older adults, about 25% of visits made by older adults are
      classified as "non-urgent". What did this study ask? What are older adults'
      reasons for seeking non-urgent care in EDs? What did this study find?
      Comprehensiveness and convenience of diagnostic and treatment services in a
      single location were the primary motivations for older adults to seek treatment
      in the ED. Why does this study matter to clinicians? Novel partnerships between
      EDs, primary and community care are needed to better address the non-urgent care
      needs of older adults.

PMID- 29843842
TI  - Safety of psychotropic medicines: contribution from observational evidence.
AB  - The risks associated with psychotropic drugs use should be accurately documented
      at the population level in view of the growing number of persons exposed to these
      drugs. The strengths of observational studies regarding the identification of
      drug-related harms mirror the limitations of randomised controlled trials and
      vice-versa. Observational studies can be carried out in large samples of
      unselected participants treated in real-life conditions and who may be followed
      up over long periods. Serious adverse effects undetected during pre-marketing
      clinical trials may be observed only in post-marketing use, such as metabolic
      effects of second-generation antipsychotics. Observational studies play a key
      role in the identification of teratogenic risks, such as those induced by
      prenatal exposure to anticonvulsants. These studies are the main source of
      information to investigate the long-term effects of drugs, such as the possible
      increased risk of dementia in benzodiazepine users. They may also contribute to
      the accurate assessment at population level of risks overestimated by studies
      carried out in non-representative samples, such as the risk of congenital heart
      diseases in babies prenatally exposed to lithium. Owing to the lack of random
      allocation of drugs, confounding by indication or by disease severity are the
      major sources of biases in observational studies exploring drug safety. An
      adverse outcome may be wrongly imputed to drug exposure while it is a
      symptom/outcome of the disease motivating the decision to prescribe. Such a bias
      may occur in studies investigating the link between exposure to antidepressants
      and suicidality. As several methods have been developed to lessen the impact of
      such biases, pharmaco-epidemiological studies based upon stringent methodological
      designs should be regarded as a valid approach for assessing psychotropic drug
      safety.

PMID- 29843841
TI  - Ice cream rounds: The adaptation, implementation, and evaluation of a peer
      support wellness rounds in an emergency medicine resident training program.
AB  - : Introduction/Innovation ConceptEmergency medicine (EM) requires physicians to
      deal with acutely ill patients in a fast-paced and dynamic environment, which
      creates a barrier to debriefing after critical events. These unique challenges
      can negatively impact wellness. We sought to adapt and implement a peer-support
      wellness program called 'Ice Cream Rounds' in an EM residency setting. METHODS: A
      needs assessment survey was conducted among EM residents at The University of
      Ottawa to gauge interest and obtain resident input regarding program design. The
      structure of the sessions was adapted from similar initiatives in Canadian
      Pediatric Residency programs.Curriculum, Tool or MaterialConfidential peer
      support sessions were created and piloted. Residents preferred peer facilitators,
      rather than staff, so two residents obtained training the Faculty of Medicine's
      Wellness Program to lead sessions. Attendance at rounds was voluntary; however,
      overall attendance was recorded along with feedback from pilot sessions.
      Discussion topics included difficult patient encounters, poor patient outcomes,
      challenges in residency, and ethical issues. Post implementation feedback
      demonstrated that Ice Cream Rounds was a helpful forum for residents to discuss
      important issues with colleagues. CONCLUSIONS: This is the first Canadian EM
      training program to adapt, implement, and evaluate peer-support wellness rounds
      for debriefing, and this initiative can be easily adopted by any EM training
      program.

PMID- 29843843
TI  - Impact of feeder space on laying hen feeding behavior and production performance
      in enriched colony housing.
AB  - Current feeder space recommendations in laying hen welfare guidelines are
      inconsistent among and within countries. One determining criterion forming the
      recommendations (e.g. 12.0 cm/hen for the EU guideline) is that all birds can
      feed simultaneously. However, if there are other resources in the environment, as
      in enriched colony housing (ECH), it is unknown whether group-housed hens will
      choose to feed simultaneously. This study assesses the impact of feeder space on
      feeding behavior of 60 laying hens (W-36) in ECH using a ultra-high frequency
      radio-frequency identification-based tracking system. The feeder spaces
      investigated were 12.0, 9.5, 8.5 and 6.5 cm/hen, achieved by blocking portions of
      the overall feeder access to keep hens at the same stocking density. Each feeder
      space treatment, randomly assigned over the course of the experiment, lasted for
      7 consecutive days. Feeding behaviors were characterized as daily time spent at
      the feeder (TS, min/hen-day), daily frequency of visits to the feeder (FV, #/hen
      day), and maximum or average percentage of hens feeding simultaneously (MPB, APB,
      %). Group-average daily feed intake (FI, g/hen-day), water use (WU, g/hen-day),
      and hen-day egg production (HDEP, %) were also measured. The results revealed
      that at 12.0 cm/hen, where unoccupied feeder space was present, a maximum of
      59.0+/-1.4% (average of 31.7+/-0.3%) hens fed simultaneously. No significant
      differences were detected among 12.0, 9.5 and 8.5 cm/hen in TS (293+/-10, 286+/
      10 and 281+/-10 min/hen-day) and MPB (59.0+/-1.4, 57.3+/-1.4 and 53.3+/-1.4%)
      (P>0.05). The outcome of no significant differences also held true between 12.0
      and 9.5 cm/hen in APB (31.7+/-0.3 v. 30.8+/-0.3%) and between 9.5 and 8.5 cm/hen
      in all response variables measured (P>0.05). However, there were significant
      differences in APB between 6.5 cm/hen and all other treatments; in TS and FV
      between 6.5 and 9.5 cm/hen; and in MPB between 6.5 and 12 cm/hen (P0.05). The
      results revealed that synchronous feeding of hens in the ECH did not increase
      with increasing feeder space. However, it is worth noting that lower feeder space
      may lead to aggression or frustration which was not quantified in the current
      study.

PMID- 29843845
TI  - Rabies - ghastly deaths are vaccine preventable.

PMID- 29843844
TI  - Childhood infectious diseases and risk of multiple myeloma: an analysis of the
      Italian multicentre case-control study.
AB  - Common childhood infectious diseases have been associated with a reduced risk of
      following haematopoietic malignancies, but investigations on multiple myeloma
      (MM) are scarce. Information about 213 MM cases and 1128 healthy controls were
      obtained from a multicentre population-based Italian case-control study. The
      association between chickenpox, measles, mumps, pertussis and rubella and the MM
      risk was estimated by unconditional logistic regression, adjusting for age,
      gender and residence area. No association was found between MM risk and any
      considered infectious disease. The number of infections was slightly inversely
      associated with the risk of MM, but statistical significance was not reached (OR
      0.87, 95% CI 0.55-1.4 for 1-2 diseases vs. none and OR 0.68, 95% CI 0.41-1.1 for
      3-5 diseases, respectively, P = 0.131). We did not find a clear evidence that
      common infections during childhood are associated with the subsequent risk of
      developing MM.

PMID- 29843846
TI  - Palliative care for drug-resistant tuberculosis: An urgent call to action.

PMID- 29843847
TI  - Unpacking Recommendation 16 of the Health Ombud's report on the Life Esidimeni
      tragedy.

PMID- 29843848
TI  - Back-to-the-future potential for autochthonous transmission of Aedes aegypti
      transmitted viruses in eThekwini and urban coastal KwaZulu-Natal Province, South
      Africa.

PMID- 29843849
TI  - The Life Esidimeni tragedy: Moral pathology and an ethical crisis.
AB  - The Life Esidimeni tragedy highlights several ethical transgressions. Health
      professionals' ethics are put to the test when their own interests are balanced
      against competing claims. Core values of compassion, competence and autonomy,
      together with respect for fundamental human rights, serve as the foundation of
      ethical practice in healthcare. These values are increasingly being challenged by
      governments and other third parties. The duties conferred on healthcare
      practitioners require them to act responsibly and be accountable for their
      actions. Codes in healthcare serve as a source of moral authority. The Gauteng
      health authorities exerted tremendous power and created a culture of fear and
      disempowerment among healthcare practitioners. When health professionals choose
      to support state interests instead of those of patients, problematic dual-loyalty
      conflicts arise.

PMID- 29843850
TI  - Co-infection with Streptococcus pneumoniae and Listeria monocytogenes in an
      immunocompromised patient.
AB  - A 34-year-old HIV-positive man with a history of chronic substance abuse was
      admitted with dual infection of Streptococcus pneumoniae and Listeria
      monocytogenes. Combined bacteraemia with S. pneumoniae and L. monocytogenes is
      very rare. To the best of our knowledge, this is the first such case documented
      at our institution and in South Africa. Ampicillin should be added to antibiotic
      regimens to improve patient outcome if L. monocytogenes infection is suspected.
      Co-infections that occur with L. monocytogenes may have conflicting antibiotic
      treatment options. This case report emphasises the need for a good relationship
      between the local microbiology pathologist and physician to select appropriate
      antibiotic treatment before definitive results are available.

PMID- 29843851
TI  - Fulminant hepatitis B virus (HBV) infection in an infant following mother-to
      child transmission of an e-minus HBV mutant: Time to relook at HBV prophylaxis in
      South African infants.
AB  - The prevalence of hepatitis B virus (HBV) infection in pregnant women is high in
      South Africa (SA), yet prophylaxis to prevent mother-to-child transmission (MTCT)
      falls short of international recommendations. We describe a 10-week-old infant
      who developed fulminant hepatic failure following MTCT. The mother was hepatitis
      e-antibody positive and had a viral load of only 760 IU/mL. Genetic analysis of
      virus from mother and infant showed that both had the G1896A mutation in the
      preC/C gene, which truncates hepatitis e antigen (HBeAg) during translation,
      causing an HBeAg-negative phenotype. HBeAg attenuates antiviral immune responses,
      and its absence was probably responsible for the infant's fulminant hepatitis,
      due to an uncontrolled immune attack on infected liver cells. Pregnant women are
      not tested for HBV infection in SA and MTCT rates are unknown. Addition of a
      birth dose of vaccine, HBV screening of pregnant women and antiviral prophylaxis
      to positive mothers should be prioritised.

PMID- 29843852
TI  - Fanconi anaemia in South Africa: Past, present and future.
AB  - Fanconi anaemia (FA) is an inherited genetic disorder characterised by somatic
      anomalies, bone marrow failure and an increased predisposition to solid tumours
      and haematological malignancies. South African (SA) black and Afrikaner
      individuals are at higher than average risk for this condition owing to genetic
      founder mutations in certain Fanconi-associated genes. This review explores the
      epidemiology, clinical presentation, diagnostic modalities and recommended care
      of affected patients, focusing on the founder population groups in SA. The early
      diagnosis of FA is important and provides improved opportunities for early
      intervention, but remains challenging.

PMID- 29843853
TI  - Differentiating Crohn's disease from intestinal tuberculosis at presentation in
      patients with tissue granulomas.
AB  - BACKGROUND: Overlapping clinical, endoscopic, radiographic and histological
      features, coupled with poor microbiological yield, make differentiating Crohn's
      disease (CD) from intestinal tuberculosis (ITB) challenging. Granulomas are
      present in both diseases; in CD they predict the need for immunosuppressive
      therapy that requires ITB to be excluded before initiation. OBJECTIVES: To
      compare granuloma-positive CD and ITB, to identify factors that may aid in
      diagnosis. METHODS: This was a retrospective cohort study evaluating granuloma
      positive CD and ITB identified from a pathology database. RESULTS: Sixty-eight
      ITB and 48 CD cases were identified. Patients with ITB were more likely to be
      male, and to have HIV infection, isolated colitis, night sweats and tachycardia.
      ITB was also associated with lower serum albumin and haemoglobin and higher C
      reactive protein levels, a chest radiograph showing active tuberculosis, and
      lymph nodes >1 cm on imaging. Extraintestinal manifestations (EIMs) were
      predictive of CD. There were no significant differences in smoking status,
      symptom duration or perianal disease. On multivariate analysis, HIV positivity
      (odds ratio (OR) 29.72, 95% confidence interval (CI) 2.15 - 410.96; p=0.01),
      isolated colitis (OR 6.17, 95% CI 1.17 - 32.52; p=0.03) and the absence of EIMs
      (OR 0.10, 95% CI 0.01 - 0.65; p=0.02) remained significant risk factors for ITB.
      CONCLUSION: This is the first study to identify clinical and biochemical factors
      to aid in differentiating granuloma-positive ITB from CD. EIMs support a
      diagnosis of CD, while isolated colitis and HIV are predictors of ITB.

PMID- 29843854
TI  - The 'ins and outs' of faecal microbiota transplant for recurrent Clostridium
      difficile diarrhoea at Wits Donald Gordon Medical Centre, Johannesburg, South
      Africa.
AB  - BACKGROUND: Clostridium difficile-associated diarrhoea (CDAD) is a potentially
      life-threatening condition that is becoming increasingly common. A persistent
      burden of this infectious illness has been demonstrated over the past 4 years at
      Wits Donald Gordon Medical Centre (WDGMC), Johannesburg, South Africa, through
      implementation of active surveillance of hospital-acquired infections as part of
      the infection prevention and control programme. Oral treatment with metronidazole
      or vancomycin is recommended, but there is a major problem with symptomatic
      recurrence after treatment. Replacement of normal flora by the administration of
      donor stool through colonoscopy or nasogastric/duodenal routes is becoming
      increasingly popular. OBJECTIVES: To identify risk factors for the development of
      CDAD in patients referred for faecal microbiota transplant (FMT) and evaluate the
      safety of administration of donor stool as an outpatient procedure, including via
      the nasogastric route. METHODS: A retrospective record review of patients with
      recurrent CDAD referred for FMT at WDGMC between 1 January 2012 and 31 December
      2016 was conducted. RESULTS: Twenty-seven patients were identified, all of whom
      fulfilled the criteria for recurrent CDAD. One-third were aged >65 years, and the
      majority were female. The most common risk factors were prior exposure to
      antibiotics or proton-pump inhibitors and underlying inflammatory bowel disease.
      Three procedures were carried out as inpatients and 24 in the outpatient
      gastroenterology unit. At 4-week follow-up, all patients reported clinical
      resolution of their diarrhoea after a single treatment and there were no
      recurrences. The FMT procedure was associated with no morbidity (with particular
      reference to the risk of aspiration when administered via the nasogastric route)
      or mortality. CONCLUSIONS: This case series confirms that FMT is a safe and
      effective therapy for recurrent CDAD. In most cases it can be administered via
      the nasogastric route in the outpatient department. We propose that the recently
      published South African Gastroenterology Society guidelines be reviewed with
      regard to recommendations for the route of administration of FMT and hospital
      admission. Meticulous prescription practice by clinicians practising in hospitals
      and outpatient settings, with particular attention to antimicrobials and chronic
      medication, is urgently required to prevent this debilitating and potentially
      life-threatening condition.

PMID- 29843855
TI  - Incidence of myocardial injury after non-cardiac surgery: Experience at Groote
      Schuur Hospital, Cape Town, South Africa.
AB  - BACKGROUND: Myocardial injury after non-cardiac surgery (MINS) is a newly
      recognised entity identified as an independent risk factor associated with
      increased 30-day all-cause mortality. MINS increases the risk of death in the
      perioperative period by ~10-fold. More than 80% of patients with MINS are
      asymptomatic, so the majority of diagnoses are missed. Awareness of MINS is
      therefore important for perioperative physicians. OBJECTIVES: To investigate the
      incidence of MINS after elective elevated-risk non-cardiac surgery at Groote
      Schuur Hospital, Cape Town, South Africa (SA). METHODS: Patients aged >=45 years
      undergoing elective elevated-risk non-cardiac surgery were enrolled via
      convenience sampling. The new fifth-generation high-sensitivity cardiac troponin
      T blood test was used postoperatively to identify MINS. Preoperative troponin
      levels were not measured. RESULTS: Among 244 patients included in the study, the
      incidence of MINS was 4.9% (95% confidence interval (CI) 2.8 - 8.5), which was
      not significantly different from that in a major international prospective
      observational study (VISION) (8.0% (95% CI 7.5 - 8.4)); p=0.080. CONCLUSIONS: Our
      SA cohort had a lower cardiovascular risk profile but a similar incidence of MINS
      to that described in international literature. The impact of MINS on morbidity
      and mortality is therefore likely to be proportionally higher in SA than in
      published international studies. The limited sample size and lower event rate
      weaken our conclusions. Larger studies are required to establish patient and
      surgical risk factors for MINS, allowing for revision of cardiovascular risk
      prediction models in SA.

PMID- 29843856
TI  - A raised serum lactate level is an independent predictor of in-hospital mortality
      in patients with isolated cerebral gunshot wounds.
AB  - BACKGROUND: Cerebral gunshot wounds (CGSWs) represent a highly lethal form of
      traumatic brain injury, and triaging these patients is difficult. The prognostic
      significance of the serum lactate level in the setting of CGSWs is largely
      unknown. OBJECTIVES: To examine the relationship between elevated serum lactate
      levels and mortality in patients with isolated CGSWs. METHODS: A retrospective
      review of the regional trauma registry was undertaken at the Pietermaritzburg
      Metropolitan Trauma Service, South Africa, over a 5-year period from 1 January
      2010 to 31 December 2014. All patients with an isolated CGSW were included.
      RESULTS: A total of 102 patients with isolated CGSWs were identified. Of these,
      92.2% (94/102) were male. The mean age (standard deviation) was 29 (8) years, and
      the in-hospital mortality rate was 21.6% (22/102). The mean serum lactate level
      was significantly higher among non-survivors than among survivors (6.1 mmol/L v.
      1.3 mmol/L; p<0.001). Lactate levels among non-survivors were <2 mmol/L in 4.5%,
      2 - 3.99 mmol/L in 9.1%, 4 - 5.99 mmol/L in 36.4% and >=6 mmol/L in 50.0%. The
      odds ratio for mortality with a lactate level of 4 - 5.99 mmol/L was 67 (95%
      confidence interval (CI) 1.7 - 2 674.2), while for a lactate level of >=6 mmol/L
      it was 1 787 (95% CI 9.0 - 354 116.1). The serum lactate level accurately
      predicted mortality even after adjustment for other variables. Based on a
      receiver operating curve analysis, an optimal cut-off of 3.3 mmol/L for serum
      lactate as a predictor for mortality was identified (area under the curve =
      0.957). CONCLUSIONS: CGSWs are associated with significant mortality, and a
      raised serum lactate level appears to be an independent predictor of in-hospital
      mortality. It is a potentially useful adjunct in the resuscitation room for
      identifying patients with a very poor prognosis.

PMID- 29843857
TI  - Healthcare-associated infections in paediatric and neonatal wards: A point
      prevalence survey at four South African hospitals.
AB  - BACKGROUND: Healthcare-associated infections (HAIs) cause substantial morbidity,
      mortality and healthcare costs. The prevalence of neonatal/paediatric HAI at
      South African (SA) district and regional hospitals is unknown. OBJECTIVES: To
      document HAI rates, antimicrobial use for HAI, infection prevention staffing,
      hand hygiene (HH) provisions and HH compliance rates in neonatal and paediatric
      wards in two district and two regional hospitals in the Western Cape Province,
      SA. METHODS: An HAI point prevalence survey (PPS) was conducted in neonatal and
      paediatric wards at two district and two regional hospitals in the Western Cape
      during December 2016, applying National Healthcare Safety Network HAI
      definitions. HAI events and antimicrobial therapy active at 08h00 on the PPS day
      and during the preceding 7 days (period prevalence) were documented. Provisions
      for HH and HH compliance rates were observed on each ward using the World Health
      Organization's HH surveillance tool. RESULTS: Pooled point and period HAI
      prevalence were 9.9% (15/151; 95% confidence interval (CI) 6 - 15.8) and 12.6%
      (19/151; 95% CI 8 - 18.9), respectively. Hospital-acquired pneumonia (5/15,
      33.3%), bloodstream infection (3/15, 20.0%) and urinary tract infection (3/15,
      20.0%) were predominant HAI types. Risk factors for HAI were a history of recent
      hospitalisation (8/19, 42.1% v. 17/132, 12.9%; p<0.001) and underlying
      comorbidity (17/19, 89.5% v. 72/132, 54.5%; p<0.004). HH provisions (handwash
      basins/alcohol hand rub) were available and functional. HH compliance was higher
      in neonatal than in paediatric wards (125/243, 51.4% v. 25/250, 10.0%; p<0.001).
      Overall HH compliance rates were higher among mothers (46/107, 43.0%) than nurses
      (73/265, 27.8%) and doctors (29/106, 27.4%). CONCLUSIONS: Neonatal and paediatric
      HAIs are common adverse events at district and regional hospitals. This at-risk
      population should be prioritised for HAI surveillance and prevention through
      improved infection prevention practices and HH compliance.

PMID- 29843858
TI  - The costs and outcomes of paediatric tuberculosis treatment at primary healthcare
      clinics in Johannesburg, South Africa.
AB  - BACKGROUND: Little up-to-date information is available about the costs of
      providing drug-susceptible tuberculosis (DS-TB) treatment to paediatric patients
      in South Africa (SA), nor have actual costs incurred at clinics been compared
      with costs expected from guidelines. OBJECTIVES: To estimate actual and guideline
      treatment costs by means of a retrospective cohort analysis. METHODS: We report
      patient characteristics, outcomes and treatment costs from a retrospective cohort
      of paediatric and adolescent (<18 years) DS-TB patients registered for treatment
      from 1 April 2011 to 31 March 2013 at three primary healthcare clinics in
      Johannesburg, SA. Actual treatment costs in 2015 SA rands and US dollars were
      estimated from the provider perspective using a standard bottom-up microcosting
      approach and compared with an estimate of guideline costs. RESULTS: We enrolled
      88 DS-TB patients (median age 4 years (interquartile range 1.0 - 9.5), 44.3%
      female, 22.7% HIV co-infected, 92.0% pulmonary TB). Treatment success was high
      (89.8%; 13.6% cured, 76.1% completed treatment), and the mean (standard deviation
      (SD)) cost per patient with treatment success was ZAR1 820/USD143 (ZAR593/USD46),
      comprising fixed costs (44.0%), outpatient visits (30.7%), medication (19.3%) and
      laboratory investigations (6.0%). This was 17% more than the mean (SD) cost
      estimated by applying treatment guidelines (ZAR1 553/USD122 (ZAR1 620/USD127)),
      with differences due mainly to higher laboratory costs and more outpatient visits
      taking place than were recommended in national guidelines. CONCLUSIONS: These
      results are the first reported estimates of paediatric DS-TB treatment costs in
      SA and show the potential cost savings of closer adherence to national treatment
      guidelines. The findings were robust in sensitivity analyses and are lower than
      previous cost estimates in adults.

PMID- 29843859
TI  - Short-term outcomes of down-referral in provision of paediatric antiretroviral
      therapy at Red Cross War Memorial Children's Hospital, Cape Town, South Africa: A
      retrospective cohort study.
AB  - BACKGROUND: The large scale-up of paediatric HIV care necessitated down-referral
      of many children receiving antiretroviral therapy (ART) from Red Cross War
      Memorial Children's Hospital (RCWMCH), Cape Town, South Africa. Few published
      data exist on the outcomes of these children. OBJECTIVES: To assess outcomes of
      children receiving ART in the first 12 months after down-referral to primary
      healthcare (PHC) clinics and identify determinants of successful down-referral.
      METHODS: A retrospective cohort study of children <15 years of age who initiated
      ART at RCWMCH and were subsequently down-referred to one of two PHC clinics
      between January 2006 and December 2012 was completed. Baseline characteristics of
      patients and caregivers as well as CD4+ counts, viral loads (VLs) and weights
      were collected 6 and 12 months after down-referral. Outcomes included retention
      in care and viral suppression. RESULTS: Of 116 children down-referred to the two
      study PHC clinics, 81.9% arrived at the designated PHC clinic and a further 8.6%
      continued care at other clinics, the remaining 9.5% being lost to follow-up. Of
      those successfully down-referred, 11.4% took >8 weeks to present, possibly
      experiencing treatment interruption. At 12 months after down-referral, only 81.0%
      remained in care. No factors were associated with retention in care in
      multivariable analysis. For children who remained in care at the designated PHC
      clinics, the clinical and immunological gains achieved prior to down-referral
      were sustained through 12 months of follow-up, and 54.7% of this cohort had
      documented viral suppression at 12 months. However, if only children with VL
      results are considered, 75.9% (41/54) were virally suppressed 12 months after
      down-referral. CONCLUSIONS: Down-referral of children on ART is complex, with
      risk of loss to follow-up and treatment interruption.

PMID- 29843860
TI  - Assessing the value of Western Cape Provincial Government health administrative
      data and electronic pharmacy records in ascertaining medicine use during
      pregnancy.
AB  - BACKGROUND: In African settings, where there is a high disease burden, there is a
      need to improve the science of documenting and analysing accurate information
      regarding medicine exposures in women immediately before and during pregnancy to
      assess the extent of use and safety in pregnant women and their unborn children.
      OBJECTIVES: To compare evidence of medicine use during pregnancy, as documented
      in paper-based clinical records (maternity case records (MCRs)) against
      electronic health information resources (Provincial Health Data Centre (PHDC))
      and assess the level of concordance between the two as part of baseline
      investigations before piloting a provincial pregnancy exposure registry and birth
      defect surveillance system. The PHDC consolidates electronic clinical and
      pharmacy data. METHODS: A folder review of completed pregnancies between November
      2013 and January 2016 was conducted on randomly selected MCRs from midwife-run
      obstetric units and a secondary maternity hospital in Cape Town, South Africa.
      Medication exposures in the MCR were captured and compared with a customised PHDC
      data extract. The type and timing of drug exposures were compared. Total
      exposures were compiled from all data sources. RESULTS: Two hundred and six MCRs
      from three facilities were sampled: 83 women had documented antiretroviral
      therapy (ART) exposure; all but 1 (1%) had been recorded in the PHDC extract.
      There was no evidence of ART use in the MCRs of 4 (5%) cases, despite evidence in
      the PHDC. There were imprecise drug names in the MCRs of 14 (17%) ART patients,
      discordant dates of onset between the MCRs and PHDC extracts in 10/83 (12%) and
      inaccurate medicine names and incorrect dates in 1 (1%) case each. Nine of 10
      (90%) women who were administered antituberculosis medication were recorded in
      the PHDC extract. Ten of 21 (48%) isoniazid preventive therapy treatments
      appeared in the MCRs and PHDC; 9 (42%) in the PHDC only and 2 (10%) in the MCRs
      only. Half (n=18/36) of all antibiotic use was reflected only in the MCRs, while
      13/36 (36%) appeared only in the PHDC extract. In the former cases, antibiotics
      used for treatment of sexually transmitted infections and urinary tract
      infections were dispensed from ward stock and not captured electronically.
      Antibiotics reflected only in the PHDC were either dispensed at a referral
      facility or before the first recorded antenatal clinic visit. Folic acid and iron
      were mostly documented in the MCR only (n=79/99 (80%) and n=107/128 (84%),
      respectively). However, analgesics and antihistamines more often appeared in the
      PHDC extract only (n=11/16 (73%) and n=5/5 (100%), respectively). CONCLUSIONS:
      The PHDC extract provided a better and more complete reflection of chronic drug
      exposures compared with the MCRs, especially when women sought care at facilities
      other than the antenatal care unit where they first attended, or when exposures
      occurred before the initial antenatal visit. The exception was antibiotics
      dispensed from ward stock to treat sexually transmitted and urinary tract
      infections.

PMID- 29843861
TI  - Determination of Eight Sulfonylurea Herbicide Residues by LC/MS/MS Using a Sample
      Separation Technique with Ethyl Acetate.
AB  - Background: Sulfonylureas are an important group of systemic herbicides mainly
      used for the control of weeds in cereals and other crops in early growth stages
      of their cultivations. Sulfonylureas are characterized by their broad spectrum
      weed control and their good crop selectivity. Objective: In the present study,
      the determination of eight sulfonylureas has been tested in wheat flour by
      applying the SweEt multiresidue method modified for dry products. Method: The
      method involves sample preparation with extraction with ethyl acetate (EEA) and
      determination of the analytes with LC/MS/MS-electrospray ionization. Its
      performance was compared with the quick, easy, cheap, effective, rugged, and safe
      (QuEChERS) method. Both methods were validated in three fortification levels
      according to European Union requirements. Results: The proposed method gave
      acceptable results as far as validation criteria are concerned, while QuEChERS
      did not result in successful recoveries in the lowest validation level, which is
      equal to the respective maximum residue limits (MRLs). Conclusions: The obtained
      results showed that the tested method showed good separation, sensitivity,
      linearity, precision, and accuracy for quantitative and qualitative analysis of
      sulfonylurea herbicides in cereals at low levels, as required by legislation. The
      analytical techniques were successfully applied to different samples of cereals,
      and no residues were determined above the reporting limit, as established at the
      lowest concentration level of each analyte being validated with acceptable
      accuracy. Highlights: Low recoveries for QuEChERS in the concentrations equal to
      the MRL. Acceptable recoveries for the EEA method in all fortification levels.
      Correlation coefficients above 0.99. Positive findings only with EEA in real
      samples.

PMID- 29843862
TI  - Multiresidue Method of Analysis of Pesticides in Medical Cannabis.
AB  - Three related analytical methods were developed and validated for the
      determination of pesticides in cannabis leaves, dried cannabis flowers, and
      cannabis oil. The methods follow the generic sequence of an acetonitrile
      extraction, followed by solid-phase extraction cleanup and analysis by HPLC
      tandem mass spectrometry (HPLC-MS/MS), GC-MS/MS, and GC-MS. These methods were
      developed to accommodate sample quantity and lipid content of the different
      matrices. Validation at a spiking level of 0.01 MUg/g was successful for 39
      pesticides in cannabis leaves and 40 pesticides in cannabis oil, and at 0.02
      MUg/g for 32 pesticides in cannabis flowers, with the majority of analytes
      showing recoveries within the acceptable range of 70-130%. With these methods
      established, unannounced inspections of Canadian licensed producers of cannabis
      revealed that out of 144 samples collected, 26 showed the presence of
      unauthorized pest control products.

PMID- 29843864
TI  - Simultaneous Preconcentration and Determination of Brilliant Blue and Sunset
      Yellow in Foodstuffs by Solid-Phase Extraction Combined UV-Vis Spectrophotometry.
AB  - Background: Brilliant Blue and Sunset Yellow, two highly water-soluble synthetic
      food dyes, are the most popular food dyes used and consumed. Although they are
      not highly toxic, some health problems can be observed when excessive amounts of
      food products containing these dyes are consumed. Objectives: The aim of the
      study was to develop a simultaneous UV-Vis combined solid-phase extraction
      method, based on the adsorption onto Amberlite XAD-8 resin, for determination of
      Brilliant Blue and Sunset Yellow dyes. Methods: Sample solution was poured into
      the reservoir of the column and permitted to gravitationally pass through the
      column at 2 mL/min flow rate. Adsorbed dyes were eluted to 5 mL of final volume
      with 1 mol/L HNO3 in ethanol solution by applying a 2 mL/min flow rate. Dye
      concentrations of the solution were determined at 483 and 630 nm for Sunset
      Yellow and Brilliant Blue, respectively. Results: The detection limits of the
      method for Brilliant Blue and Sunset Yellow were determined as 0.13 and 0.66
      ng/mL, respectively. Preconcentration factor was 80. Brilliant Blue contents of
      real food samples were found to be between 11 and 240 MUg/g. Sunset Yellow
      concentrations of foodstuffs were determined to be between 19 and 331 MUg/g.
      Conclusions: Economical, effective, and simple simultaneous determination of
      Brilliant Blue and Sunset Yellow was achieved by using a solid-phase extraction
      combined UV-Vis spectrometry method. Highlights: The method is applicable and
      suitable for routine analysis in quality control laboratories without the need
      for expert personnel and high operational costs because the instrumentation is
      simple and inexpensive.

PMID- 29843863
TI  - Superparamagnetic Iron Oxide-enhanced Magnetic Resonance Imaging of Spontaneous
      Hepatic Neoplasia in a Cynomolgus Macaque (Macaca fascicularis).
AB  - Although the number of reports describing tumors in aged NHP has increased,
      spontaneous neoplasias in NHP are extremely rare, with the notable exception of
      prosimians, in which spontaneous hepatic neoplasms arise. In addition to
      radiography and ultrasonography, superparamagnetic iron oxide (SPIO)-enhanced MRI
      tends to be applied in human practice to non-invasively locate, identify, and
      size liver tumors and to define the border between neoplastic and normal tissues.
      Here we report a 13-y-old female cynomolgus monkey with anorexia and
      serologically normal liver enzymes. After fluid therapy, the condition remained
      in remission for several months. Later, however, a palpable mass was assessed by
      using ultrasonography, radiology, and SPIO-MRI; T2-weighted images revealed a
      clear border between a hepatocellular carcinoma and normal liver tissue. Findings
      at necropsy supported the imaging data. Serologic assessment after euthanasia
      revealed a positive reaction to an abnormal form of prothrombin (PIVKA-II). We
      recommend SPIO-MRI as a practical and useful for diagnosing hepatocellular
      neoplasias in NHP. This study is the first to demonstrate the applicability of
      SPIO-MRI for the identification of hepatocellular carcinoma in NHP.

PMID- 29843865
TI  - Manufacture of Gluten Free Oats for Gluten Compliance at the Serving Level: An
      Attainable Industrial Standard.

PMID- 29843866
TI  - Performance Comparison Between Monolithic, Core-Shell, and Totally Porous
      Particulate Columns for Application in Greener and Faster Chromatography.
AB  - Background: The introduction of monolithic rods and core-shell particles as new
      morphologies of packing materials different from the conventional totally porous
      particles resulted in a leap forward for performance in LC. Meanwhile,
      environmental safety has become increasingly important in many areas, especially
      in industry and research laboratories. Objective: This study compared the
      efficiencies of commercially available columns of different lengths and diameters
      when greener chromatographic conditions were utilized. The main purpose of this
      study is to help practitioners select the most appropriate stationary phase for
      faster and greener analysis. Methods: The three types of stationary phases were
      compared in terms of separation efficiency, number of theoretical plates, peak
      shape, selectivity, resolution, analysis time, mobile phase consideration, and
      permeability using six drug molecules. Results: Results indicated that core-shell
      and monolithic stationary phases had superiority over the conventional totally
      porous particles in terms of efficiency and speed of analysis. Monolithic rods
      had lower column backpressure and higher permeability, so they are more suitable
      for higher mobile phase flow rates and viscosities. However, core-shell particles
      provided enhanced peak shapes and number of theoretical plates. Conclusions: The
      choice will depend on the main purpose of analysis and the composition of the
      mobile phase. Compromise must be made to obtain the best trade-off between
      separation efficiency and analysis speed. Highlights: This study is the first to
      consider green chromatography concepts for the selection of the best stationary
      phase of new morphologies.

PMID- 29843867
TI  - Simultaneous Detection of Yersinia Enterocolitica and Listeria Monocytogenes in
      Foodstuffs by Capillary Electrophoresis and Microchip Capillary Electrophoresis
      Laser-Induced Fluorescence Detector.
AB  - Background: Food safety is one of the most important public health problems in
      the world, and pathogenic bacterium is a major factor causing serious foodborne
      diseases. Objective: Two methods of duplex PCR combined with capillary
      electrophoresis laser-induced fluorescence detector (CE-LIF) and microchip
      capillary electrophoresis laser-induced fluorescence detector (MCE-LIF) have been
      developed for the simultaneous detection of Yersinia Enterocolitica and Listeria
      Monocytogenes in various foods. The specific conservative sequences of these two
      bacteria were amplified. Methods: After labelled with nucleic acid dye SYBR Gold
      and SYBR Orange, the PCR products were analyzed by CE-LIF and MCE-LIF,
      respectively. Under the optimal conditions, the detection of PCR products of the
      target bacteria was achieved in less than 15 min by CE-LIF and within 6 min by
      MCE-LIF. Results: The alignment analysis demonstrated that the PCR products had
      good agreement with the sequences published in GenBank. The CE-LIF method could
      detect 10 CFU/mL Y. enterocolitica and L. monocytogenes, and the MCE-LIF method
      could detect 100 CFU/mL Y. enterocolitica and L. monocytogenes. The intraday
      precisions of migration time and peak area of DNA markers and PCR products were
      in the range of 1.13 to 1.18% and 1.60 to 6.29%, respectively, for CE-LIF and
      1.18 to 1.48% and 2.85 to 4.06%, respectively, for MCE-LIF. Conclusions: The
      proposed methods could be applied to target bacterial detection infood samples
      rapidly, sensitively, and specifically. Highlights: Two new methods based on CE
      and MCE have been developed for the simultaneous detection of Y. enterocolitica
      and L. monocytogenes in foodstuffs, and they can detect the bacteria directly
      without any enrichment because of their high sensitivity.

PMID- 29843868
TI  - Ultrasensitive DNA Detection with Hydrodynamic Separation of Plasmonic
      Nanoparticles and Isothermal Amplification.
AB  - Nucleic acid based assays are routinely used to detect diseases and monitor
      medical treatment. Here, we demonstrated a novel approach for colorimetric DNA
      detection using plasmonic gold nanoparticles (AuNPs) as hydrodynamic separators
      coupled with differential centrifugation. This approach relies upon the change in
      the sedimentation rate of AuNPs when conjugated to DNA amplicons. Isothermal
      nucleic acid amplification results in the formation of unique DNA amplicons that
      is large enough to prevent the sedimentation of conjugated AuNPs at a specific
      centrifugal force. In contrast, free nanoparticles are readily centrifuged and
      the solution color changes to colorless, enabling accurate and quantitative
      detection of the targeted DNA. This approach was challenged for the detection of
      sdfI gene of Salmonella. The decline of the red color intensity of AuNPs was
      linear to the concentration of the targeted DNA from 1.2 * 101 copies/ml to 1.2 *
      107 copies/ml and the detection limit was as low as 120 copies/ml (S/N = 3). This
      simple platform could be used to establish inexpensive and sensitive assays for
      clinical and in-field diagnostic applications.

PMID- 29843869
TI  - Optimal Design of Novel Functionalized Nanoconjugates Based on Polymalic Acid for
      Efficient Tumor Endocytosis with Enhanced Anticancer Activity.
AB  - To overcome the strong negative charge and improve the endocytosis of poly-beta
      malic acid (PMLA) as a drug carrier, a pH-sensitive nanoconjugate of PMLA/hyd
      PEG5000/PEG2000-TAT/DOX (PHPTD) was developed. The trans activator of
      transcription (TAT) modified with polyethylene glycol2000(PEG2000) was conjugated
      with the PMLA backbone which improved the endocytosis of PMLA. PEG5000 was
      utilized to shield TAT by a pH-sensitive hydrazone (Hyd) bond. In order to
      decrease the potential risk of accelerated blood clearance (ABC) phenomenon by
      anti-PEG IgM, the minimal content of TAT for penetrating tumor cells and the
      optimal protecting layer density of PEG5000 were screened. The result showed that
      0.3 mol% TAT was enough to efficiently improve cellular uptake of PMLA (30 kda).
      The cytotoxicity and the 1H-NMR results indicated that 3.6 mol% PEG5000-modified
      nanoconjugates could shield 0.3 mol% TAT. The antitumor effect in breast cancer
      cells (MDA-MB-231) in tumor-bearing BALB/C mice demonstrated that this
      nanoconjugates exhibits high therapeutic efficiency in artificial solid tumors
      and low toxicity to normal tissues. It is indicated that TAT could be hidden in
      the long chain of PEG5000 at a neutral pH, when arrival to the tumor
      extracellular microenvironment, PEG5000 was cleaved from the nanoconjugates
      through the hydrazone bond due to the acidic tumor environment. Then, TAT was
      exposed, allowing the nanoconjugates to be transported into tumor cells. Our
      findings provide important and detailed information regarding the optimal content
      of TAT and the shielded density of PEG5000 and reveal their abilities of tumor
      penetration and potential for the efficient drug carrier.

PMID- 29843870
TI  - Self-Assembled Nanocomplex for Co-Delivery of Arsenic-Retinoic Acid Prodrug into
      Acute Promyelocytic Leukemia Cells.
AB  - The synergistic effect of arsenic (As) and all-trans retinoic acid in acute
      promyelocytic leukemia (APL) has been well documented. However, several major
      issues impeding the efficient delivery of these drugs for APL therapy remain
      unsolved. The low solubility of retinoic acid in physiological solutions makes
      drug delivery cumbersome, and the high systemic cytotoxicity of arsenic trioxide
      leads to unwanted side effects. In the present study, a new organo-arsenic
      molecule was synthesized via template-directed ring-opening esterification of an
      epoxy arsenic hydride (2-chloro-1,3,2-dioxaarsolane, CDA) under a nucleophilic
      attack exposing the hydroxyl terminus. The additional single step conjugation
      with retinoic acid (RA) and polyethylene glycol (PEG) yielded the amphiphilic
      prodrug PEG-As-RA that readily self-assembles into nanoparticles in the aqueous
      phase. The assembled nanoparticles containing both arsenic and RA exhibit high
      water solubility and good biocompatibility. In addition, they are highly stable
      in physiological buffers and are efficiently taken up by human APL cells. In vivo
      imaging results showed that the nanoparticles are characterized by prolonged
      blood circulation, and release both RA and As via hydrolysis to provide
      combination therapy for human APL. This novel organo-arsenic molecule conjugated
      with RA offers a new approach to the treatment of APL.

PMID- 29843871
TI  - Construction of High Sensitive CD133 Immune PLGA Magnetic Spheres Platform for
      Lung Cancer Stem Cells Isolation and Its Property Evaluation.
AB  - High sensitive immune CD133 PLGA magnetic spheres platform is constructed to
      isolate and enrich lung cancer stem cells in order to study their biological
      characteristics, such as their proliferation, self-renewal and invasion and
      metastasis in vitro. The expression of the specific transcription factors Oct 4
      and Nanog genes of stem cells were detected by immunofluorescence and RT-PCR. The
      tumorigenic capacity of lung cancer cells were studied using the tumorigenesis
      experiment in nude mice in vivo. The results indicated that the CD133 immune PLGA
      magnetic beads (with diameter 356.25 +/- 0.64 nm) can effectively separate more
      lung cancer stem cells under the serum-free suspension culture compared with MACS
      CD133 MicroBead Kit. Some A549 cells sorted magnetically could form stable tumor
      suspended spheres that were able to undergo passage stably after 3 to 6 days. The
      self-renewal, clonal formation and invasion and metastasis capacities of the
      suspended spheres were higher than those of the parent cells (P < 0.05). The
      expressions of Oct 4 and Nanog mRNA in stem cells were significantly elevated (P
      < 0.05), and the A549 suspended spheres could significantly improve the in vivo
      tumorigenic capacity of nude mice. Among the peripheral blood of 20 patients with
      lung adenocarcinoma, CD133+ cells were isolated from the peripheral blood of 14
      (70%), and CD133+ cells sorted from 11 (55%) patients were cultured into spheres.

PMID- 29843872
TI  - Comparative Analysis of microRNA Expression Profiles of Exosomes Derived from
      Normal and Hypoxic Preconditioning Human Neural Stem Cells by Next Generation
      Sequencing.
AB  - Stroke recovery is associated with neural stem cell (NSC) development and
      neurovascular unit reconstruction. The exosome, as an important intercellular
      player in neurovascular communication, mediates neuro-restorative events by
      transferring exosomal protein and RNA cargoes. In this study, we explored the
      role of exosomal microRNAs (miRNAs) in human NSCs (hNSCs), and analyzed the
      expression profiles of miRNAs in hNSC-derived and hypoxic preconditioning hNSC
      derived exosomes with the help of next generation sequencing (NGS). The results
      demonstrated that a certain proportion of miRNAs were differentially expressed in
      both exosomes. In addition, target gene prediction and Gene Ontology (GO)
      enrichment analysis showed that these genes were associated with differential
      miRNAs primarily participating in biological processes (regulation of cellular
      process), cellular component (intracellular membrane-bounded organelle), and
      molecular function (binding). Kyoto Encyclopedia of Genes and Genomes pathway
      (KEGG) pathway enrichment data suggested that most of targeted genes involved in
      PI3K-Akt, Hippo, MAPK, mTOR, and Endocytosis etc. signaling pathways. We
      identified the interesting and important expressed miRNA and considered that miR
      98-3p might be a special hNSC-derived exosomal-miRNA which was significantly
      downregulated under hypoxic preconditioning. The hNSCs-derived exosomes were
      capable of modulating gene expression or promoting stroke therapy. We observed
      that after hypoxic preconditioning, the functions of these exosomes were changed,
      and exosomal-miRNAs expression profile was different. In summary, our study
      suggested that hNSC-derived exosomal miRNAs including hypoxic preconditioning
      exosomal miRNAs provided a new strategy for the diagnosis and treatment of stroke
      patients.

PMID- 29843873
TI  - Immunomagnetic Lipid Separation and Plastin Identification for Pancreatic Cancer
      Cells and Its Clinical Application.
AB  - Circulating tumour cells isolated from the peripheral blood of patients have the
      advantage of being non-invasive. The aim of this study was to develop an
      effective method for detecting pancreatic cancer micrometastasis from peripheral
      blood and explore the clinical application value of the separation of circulating
      pancreatic cancer cells using epithelial cell adhesion molecule (EpCAM) lipid
      magnetic spheres (ELMS) and plastin monoclonal antibody for identification. The
      pancreatic cancer PANC-1 cells were respectively added to phosphate-buffered
      saline (PBS) and fresh blood provided by healthy volunteers to detect cell
      recovery using ELMS. Moreover, trials were conducted using nude mice with tumour
      and samples from patients with pancreatic cancer to evaluate the effect of CTC
      isolation and identification. The prepared ELMS captured PANC-1 cells from blood
      with high efficiency, which was similar to the efficiency obtained with nude mice
      with tumour and the samples from patients with pancreatic cancer, in agreement
      with the clinical test results. This study is based on the high efficiency of the
      EpCAM magnetic nanolipid sphere separation system capturing CTC of pancreatic
      cancer, which provides a strong support for investigating pancreatic cancer, in
      terms of its early diagnosis, preoperative and post-operative analysis and
      analysing the treatment effects.

PMID- 29843874
TI  - Polydimethylsiloxane (PDMS)-Based Flexible Optical Electrodes with Conductive
      Composite Hydrogels Integrated Probe for Optogenetics.
AB  - Optical electrodes are important tools for optogenetic research. Flexible optical
      electrodes represent a refinement over traditional fiber-based electrodes because
      they contact with target cells gently by reducing mechanical mismatch, thereby
      enhancing their long-term, stable signal acquisition capability. Until now,
      little attention has been paid to flexible intracortical optical electrodes.
      Here, we reported a novel flexible penetrating optical electrode with a probe
      made of composite hydrogels. We used polydimethylsiloxane (PDMS), a kind of
      transparent material, to fabricate waveguide by capillary assembly method with
      two tungsten wires inside providing mechanic support. Then one tungsten wire was
      withdrawn out and the microchannel was filled with hydrogel composed of polyvinyl
      alcohol (PVA), multi-walled carbon nanotubes (MWCNT), poly(3,4
      ethylenedioxythiophene) (PEDOT), and polystyrene sulfonate (PSS) as an electrical
      recording and stimulation probe. With PDMS as the waveguide and
      PVA/MWCNT/PEDOT/PSS hydrogel as the electroprobe, the optical electrode becomes a
      flexible package. The morphology observed by scanning electron microscopy showed
      that the PVA/MWCNT/PEDOT/PSS hydrogel had a loose surface structure, which would
      allow the effective adhesion to target neurons. A buckling test showed that our
      electrode maintained bending strength comparable to that of previously reported
      flexible penetrating electrodes. Finally, the electrical properties showed a
      lower impedance and higher charge capacity after PEDOT/PSS modification. The
      flexible penetrating optical electrode we developed may be used for long-term in
      vivo optogenetics studies.

PMID- 29843875
TI  - Redox-Responsive Supramolecular Micelles for Targeted Imaging and Drug Delivery
      to Tumor.
AB  - The tumor-selective drug delivery system based on supramolecular micelles that
      were self-assembled by amphiphilic beta-cyclodextrins (beta-CD) with redox
      responsiveness and fluorescence have been developed. The amphiphilic beta-CD were
      formed by anthraquinone (AQ) and cyclodextrins with disulfide bond in between.
      The disulfide bond is in charge of the responsiveness, while the AQ moiety serves
      as fluorescent probe. The tumor targeting was introduced by the host-guest
      inclusion complex between beta-CD and folate (FA), due to the known folate
      receptor mediated endocytosis. The responsive disintegration of this beta-CD-AQ
      FA micelles and coinstantaneous drug releases happened with cleavage of disulfide
      bond following tumor targeting and cell endocytosis, which was triggered by
      massive glutathione in the cytoplasm of tumor cells. The highly selective
      particle uptake by tumor cells and subsequent efficient drug delivery to these
      cells, which were directly demonstrated by fluorescence microscopy, resulted in
      an over twofold efficacy against tumor cells compared with normal cells, as well
      as higher tumor cytotoxicity than that caused by free drugs. These results
      indicate that these beta-CD-AQ-FA micelles, with performance of selective drug
      delivery, responsive drug release, effective drug tracking and tumor labeling,
      could be a promising platform for better therapeutic effects in cancer treatment.

PMID- 29843876
TI  - Highly Sensitive Detection of Glucose by a "Turn-Off-On" Fluorescent Probe Using
      Gadolinium-Doped Carbon Dots and Carbon Microparticles.
AB  - Carbon dots, as a potential substitute for semiconductor quantum dots, have drawn
      great interest in recent years. The preparation of fluorescent carbon dots has
      been made easy with many significant advances, but the complicated purifying
      processes, low quantum yield, and blue emission wavelength still limit its wider
      application in biosensors, biomedicine, and photonic devices. Here we report a
      strategy to synthesis Gd-doped carbon dots (Gd-Cdots) of super-high quantum yield
      with a microwave assisted hydrothermal method. The Gd-Cdots, with a diameter of
      47~8 nm, can be purified easily with conventional centrifugal techniques. Carbon
      microparticles (CMPs) have also been synthesized with a similar procedure.
      Meanwhile, we demonstrated a novel "turn-off-on" fluorescent biosensor, which has
      been developed for highly sensitive detection of glucose using Gd-doped carbon
      dots as probes. The proposed biosensor has exhibited low-cost and non-toxic
      properties, with high sensitivity and good specificity. In addition, the results
      in real blood samples further confirmed it as a promising application in diabetes
      diagnosis.

PMID- 29843877
TI  - Anticancer Supramolecular Hydrogel of D/L-Peptide with Enhanced Stability and
      Bioactivity.
AB  - Supramolecular nanofibers based on D-amino acid-containing peptide self-assembly
      have attracted increased interest recently because of their superior
      biostability. However, the construction of nanostructures containing D-amino
      acids is still insufficient at present, and their application in biomedical
      fields should be further explored. Herein, we demonstrated that the aggregation
      property of hydrophobic anticancer tyroservaltide (YSV) could be decreased by
      introducing D-amino acids. Using such strategy, we fabricated a novel anticancer
      hydrogelator based on the D/L-peptide of NapGDFDFDYGYSV (D-YSV). Through a
      heating-cooling process, NapGDFDFDYGYSV self-assembled into a stable hydrogel,
      while its control peptide of NapGFFYGYSV (L-YSV) self-assembled into an unstable
      suspension. The nanofiber of D-YSV exhibited an excellent resistance to
      proteinase digestion comparing with that of L-YSV, and a better anticancer
      efficiency in vitro due to its improved cellular uptake. Moreover, D-YSV
      possessed good biocompatibility and showed a prominent tumour inhibition capacity
      in vivo via tail vein injection. Our study demonstrates a powerful strategy to
      reduce the aggregation property and construct supramolecular hydrogels of
      bioactive hydrophobic L-peptides.

PMID- 29843878
TI  - Doxorubicin-Loaded Dextran-Modified GoldMag Nanoparticles for Targeting
      Hepatocellular Carcinoma.
AB  - Doxorubicin (Dox) is one of the most widely used chemotherapeutic agents for many
      types of cancer, including hepatocellular carcinoma. However, clinical
      applications of Dox are limited due to its non-selective cytotoxicity that
      results in severe adverse effects. To tackle this problem targeted delivery of
      Dox exclusively to tumour milieu has become clinically prioritised. In this
      study, we first synthesized and validated Dextran coated GoldMag Nanoparticles
      (DGMNs) as a potential delivery vehicle for Dox. We then evaluated the
      cytotoxicity of Dox-DGMNs, the drug and carrier composites, under guidance of
      external magnetic field (EMF) in hepatocellular carcinoma cell lines and in
      tumour grafts. Intriguingly, DGMNs exhibited the capacity to prolong Dox release
      in vitro; hence, Dox-DGMNs significantly enhanced the therapeutic efficiency of
      the drug in vitro and in vivo, especially under EMF. However, DGMNs were able to
      significantly decrease systemic adverse effects and inhibit tumour growth
      compared to the intravenous application of free Dox. Molecular analysis revealed
      that tumour cells were more affected by Dox-DGMNs with EMF than Dox-DGMNs or Dox
      alone in terms of apoptosis and DNA damage marker expression. Overall, DGMNs
      exhibited a substantial potential to serve as a promising drug delivery carrier
      for magnetically targeted cancer therapy.

PMID- 29843879
TI  - Inhibition of Al(III)-Induced Abeta42 Fibrillation and Reduction of Neurotoxicity
      by Epigallocatechin-3-Gallate Nanoparticles.
AB  - RATIONAL: Accumulation of amyloid beta fibrils is the pathological hallmark of
      Alzheimer's disease. Epigallocatechin-3-gallate (EGCG) has shown to possess
      potent anti-amyloidogenic, metal chelation and antioxidant properties. However,
      its therapeutic potential is limited in-vivo due to its poor bioavailability and
      stability. Therefore, the present study aims to evaluate the neuroprotective role
      of EGCG nanoparticles (nanoEGCG) against Al(III)-induced Abeta42 fibrillation in
      vitro. METHOD: NanoEGCG was synthesized and its physiochemical characterization
      was performed. In-vitro release profiles and stability of nanoEGCG in simulated
      gastro-intestinal fluids, along with its antioxidant and metal chelation
      potential was evaluated. The anti-amyloidogenic potential of nanoEGCG on Abeta42
      secondary structure and its morphology was evaluated via induction with Al(III)
      and nanoEGCG treatment. Further, the effect of Abeta42 on cellular toxicity was
      also assessed. RESULT: NanoEGCG with 96% encapsulation efficiency and a
      hydrodynamic diameter of 300 nm with spherical to slightly ellipsoid shape was
      synthesized. EGCG release from the nanoparticle occurred in a sustained manner
      and was stable when released in simulated gastro-intestinal fluids. The
      antioxidant and metal chelation potential of nanoEGCG over time was better than
      its free form. Effective inhibition of both Abeta42 and Al(III) induced Abeta42
      fibrillation with nanoEGCG treatment was noted. This was achieved through the
      generation of soluble Abeta42 amorphous aggregates instead of insoluble Abeta42
      oligomers and fibril generation. Significant reduction in cellular toxicity was
      also noted when treated with nanoEGCG. CONCLUSION: In conclusion, this study
      strengthens the hypothesis that EGCG nanoparticles can inhibit Al(III)-induced
      Abeta42 fibrillation and its neurotoxicity in-vitro.

PMID- 29843880
TI  - Multifunctional Bismuth Ferrite Nanoparticles as Magnetic Localized Dose
      Enhancement in Radiotherapy and Imaging.
AB  - Recently bismuth-based nanoparticles have drawn extensive attention as
      radiosensitizer in radiotherapy due to high atomic number, low toxicity, and low
      cost. This study aims to introduce the applicability of bismuth ferrite
      nanoparticles (BFO, BiFeO3) as a new multifunctional theranostic agent for
      radiotherapy, magnetic resonance imaging (MRI), and computed tomography (CT) as
      well as magnetic hyperthermia mediator. After evaluation of BFO nanoparticles
      biocompatibility which were synthesized by conventional sol-gel method, we
      investigated dose enhancement property of BFO nanoparticles with gel dosimetry,
      clonogenic, and cck8 assay. According to clonogenic assay, sensitizer enhancement
      ratios (SERs) were obtained as 1.35 and 1.76 for nanoparticle concentrations of
      0.05 mg/ml and 0.1 mg/ml, respectively. For high concentration (0.5 mg/ml), dose
      enhancement effect of BFO nanoparticles was demonstrated by gel dosimetry. To
      prove the contrast enhancement of BFO nanoparticles in MR and CT imaging, the
      relaxation time rate (R2) and Hounsfield unit (HU) were measured, respectively.
      It was found that the R2 and Hu have linear relationship with the nanoparticle
      concentrations. Moreover, whereas BFO nanoparticles have magnetic properties, we
      measured inductive heating property of the nanoparticles in external alternative
      magnetic field to evaluate their applicability as magnetic hyperthermia mediator.
      A rapid temperature increment was detected under alternative magnetic field (12.2
      kAm-1 and 17.2 kAm-1, frequency 480 kHz) owing to the high concentration of BFO
      nanoparticles. Collectively, our experimental investigation results proved that
      the multifunctional BFO nanoparticles could be employed as a multimodal imaging
      and radio-thermotherapeutic agent to enhance theranostic efficacy.

PMID- 29843881
TI  - The Preparation of C-Reactive Protein Immunosensor Based on Nano-Mimetic Enzyme
      Co3O4.
AB  - In this work, a nano-mimetic enzyme Co3O4 nanoparticles with catalytic effect on
      the reduction of H2O2, was synthesized and used to label C-reactive protein
      antibody. Au nanoparticles (Au NPs) were loaded on COF-TpPa-1 to form Au NPs@COF
      TpPa-1 with good biocompatibility and adsorption ability. A sandwich C-reactive
      protein immunosensor was prepared using Au NPs @COF-TpPa-1 as the immobilization
      matrix. The catalytic current of Co3O4 nanoparticles to the reduction of H2O2 was
      measured by the chronoamperometry which is in proportion to the concentration of
      CRP. The linear range of this immunosensor was 0.05-80 ng/mL with the linear
      correlation coefficient of 0.9955. The method demonstrated a good sensitivity
      with a detection limit of 0.017 ng/mL (S/N = 3) for CRP. When the C-reactive
      protein immunosensor was applied to real serum samples analysis, the satisfied
      results were obtained, indicating that the immunosensor is of prospect of
      application.

PMID- 29843882
TI  - Neural Stem Cells Alleviate Inflammation via Neutralization of IFN-gamma Negative
      Effect in Ischemic Stroke Model.
AB  - Inflammatory response generated by ischemic stroke commonly affects functional or
      structural recovery. The aim of this study was to examine the IFN-gamma caused
      inflammatory effects on NSCs in vitro and in vivo. We found that IFN-gamma did
      not affect NSCs proliferation but increased the SOD2 level of inflammatory
      oxidative stress in NSCs culturing. High dose IFN-gamma (500 ng) injection
      aggravated the level of inflammation in the cerebral ischemic model but did not
      alter the repairing functions of the NSCs in vivo. NSCs based treatment,
      including the NSCs-IFN-gamma combined treatment, significantly improved the
      ischemic microenvironment by decreasing CD4+, CD8+ T cells and microglia
      infiltration. Furthermore, anti-inflammatory cytokines IL-10 and TGF-beta1
      expression were increased in the NSCs and combined treatment groups, but the
      level of pro-inflammatory cytokines (IL-1 beta, IL-6, IFN-gamma, and TNF-alpha)
      were decreased. The IFN-gamma/Stat1 signaling pathway was also activated. NSCs
      transplantation therefore promoted the neurological recovery of ischemic stroke
      rats mainly by altering the inflammatory microenvironment, neutralizing the
      negative effect of IFN-gamma. In conclusion, in addition to promoting cell
      replacement or engraftment, the NSCs-based transplantation also enhanced the
      therapeutic effects of transplantation by optimizing its immune microenvironment
      of ischemic areas.

PMID- 29843883
TI  - Survey of Musculoskeletal Disorders Among Indian Dancers in Mumbai and Mangalore.
AB  - Classical Indian dance has earned recognition across the globe; however, the
      health of dancers who are carrying forth this heritage has not received due
      attention. Therefore, this study aimed to explore musculoskeletal pain and injury
      prevailing among Indian dancers in Mumbai and Mangalore. A secondary aim was to
      compare pain tolerance levels between dancers and non-dancers. Fifty-one dancers
      trained in different traditional Indian and Western dance forms and 164
      recreational dancers were recruited as participants. An indigenous questionnaire
      was designed and validated by physical therapists across various levels of
      experience and dancers across various training levels. The questionnaire recorded
      dance, pain, and injury profiles. Additionally, pain tolerance was evaluated
      using the Pain Sensitivity Questionnaire among dancers and healthy age- and
      gender-matched controls (N = 200). Descriptive statistical analysis was performed
      to present results of the site of current pain, site of past injury, perceived
      causes of injury, and exercise routine. The Student's t-test was used to compare
      Pain Sensitivity Questionnaire scores between dancers and non-dancers, and
      independent one-way ANOVA was used to compare scores among dancers practicing
      different dance forms. For both current pain and past injury, dancers reported
      the back (42.5%) followed by the knee (28.3%) and ankle (18.6%) as the most
      common sites. Stress was the most commonly perceived cause of injury (34.4%),
      followed by over work (24.7%), tiredness (17.2%), and falls (13.5%). Warm-up
      exercises were always performed by 43.30% of dancers, whereas only 20% performed
      stretching after dance. Almost 60% of dancers participated in forms of exercise
      other than dance, e.g., swimming, yoga, and aerobics. Pain sensitivity was not
      significantly different between dancers and non-dancers (p = 0.159). Level of
      training and gender did not influence pain.

PMID- 29843884
TI  - Lower Extremity Horizontal Work, But Not Vertical Power, Predicts Balance
      Performance in Female Collegiate Dancers.
AB  - Dancers, similar to other athletes, often perform vertical and horizontal jumps.
      Lower extremity (LE) work, power, and balance are important in performing these
      movements. However, whether these qualities are inter-related in dancers remains
      unclear. Our purposes were to examine if 1. LE horizontal work, vertical power,
      and balance were inter-related, and 2. LE horizontal work and vertical power
      would predict balance in female collegiate dancers. Sixty-one collegiate female
      dancers (18.3 +/- 0.7 years; 164.7 +/- 7.3 cm; 61.7 +/- 9.5 kg) performed Single
      Leg Hops (SLH, m), and Vertical Jumps (VJ, cm). The resulting distances were used
      to calculate horizontal work (hWork, joules = weight[N] * SLH), and vertical
      power (vPower, watts = 78.5 * VJ + 60.6 * mass[kg] 15.3 * height [cm] 1,308).
      Balance was operationally defined as the bilateral composite Star Excursion
      Balance Test (SEBTcom, % leg-length-LL) reach scores in the anterior,
      posterolateral, and posteromedial directions. Pearson correlation coefficients
      examined relationships among hWork, vPower, and SEBTcom. A stepwise linear
      regression examined whether hWork and vPower predicted balance (p <= 0.05).
      SEBTcom (75.7 +/- 6.2% LL) showed moderate correlations to hWork (800.3 +/- 191
      joules; r = 0.59, p < 0.001), and fair correlations to vPower (3289.1 +/- 1047.7
      watts; r = 0.31, p = 0.02). hWork showed moderatestrong correlations to vPower (r
      = 0.70, p < 0.001). hWork predicted 32.4% of the balance score variance (p <
      0.001), but vPower did not enter the regression model. Overall, LE horizontal
      work, vertical power, and balance were positively correlated in female collegiate
      dancers. LE horizontal but not vertical power predicted almost one-third of the
      changes in balance. The similar horizontal directional task demands in both the
      SEBT and SLH versus the differing horizontal and vertical directional task
      demands in the SEBT and the VJ, respectively, may partially explain these
      findings. As LE work, power, and balance are interrelated, whether dancers'
      participation in training programs can improve their jumping, landing, and
      balance performance needs further examination.

PMID- 29843885
TI  - The Effect of Physical Therapist Involvement in the Diagnosis and Treatment of
      Youth and Adolescent Dancers' Injuries.
AB  - In studies of major dance companies that employ mostly adult dancers, measuring
      the effect of comprehensive medical management that includes daily on-site
      physical therapy has shown a decrease in the incidence of dance injuries, days
      missed from dance, injury-related costs, and Workers Compensation claims. As no
      comparable data have been collected with regard to youth and adolescent dancers,
      we sought to assess the effect of physical therapist involvement in the care of
      injuries sustained by young dancers on the incidence and amount of time missed
      from dancing. A cross sectional study was conducted by questionnaire of 55
      students attending a US school for the arts summer dance program. Dancers ranged
      in age from 13 to 17 years, with a mean age of 15.0 +/- 1.0. Most (87.3%) were
      female. Participants reported dancing a mean of 4.4 +/- 2.6 hours per day prior
      to arrival at the program. They recorded 37 prior injuries, most of which (51.4%)
      were diagnosed by a physician, although a substantial proportion were diagnosed
      by a physical therapist (43.2%). Dancers whose injuries were diagnosed by a
      physician were more likely to miss dance class than those diagnosed by a physical
      therapist (100% vs. 50%; p = 0.014). When an injury did result in missed dance
      time, the median number of days missed was greater when the diagnosis was made by
      a physician as opposed to a physical therapist, although this finding was not
      statistically significant (6.0 vs. 2.5 days; p = 0.203). This supports previous
      literature showing a beneficial effect of health care management that involves
      physical therapists, especially those with expertise in dance injuries, on
      outcomes from dance injuries sustained by adult dancers.

PMID- 29843886
TI  - The Effect of Footwear on Free Moments During a Rotational Movement in Country
      Swing Dance.
AB  - Footwear in dance has been studied for support and cushioning, but little
      research has been conducted on free moments, which may result from high
      frictional coefficients. Conversely, insufficient friction between shoes and
      floors may increase the risk of falls and compromise dance performance. The
      purpose of this study was to examine the effect of different types of footwear
      with different coefficients of friction on peak and average free moments during a
      rotational movement in country swing dance. Fifteen country swing dancers
      completed a rotational movement under four footwear conditions: barefoot, rubber
      bottom boots, leather-bottom boots, and running shoes. The peak and average free
      moments applied to the left and right legs were measured using two force plates.
      Coefficients of static friction between different shoes and force plate surfaces
      were quantified and found to be greater for the rubber-bottom boots and running
      shoes than the leather-bottom boots. For the left (push off) leg, free moments
      were greater for the running shoe and rubber-bottom boot conditions compared to
      the barefoot and leather-bottom boot conditions. For the right (rotating) leg,
      free moments were greatest for the running shoe condition, second greatest for
      the barefoot and rubber-bottom boot conditions, and least for the leather-bottom
      boot condition. The leatherbottom boots may decrease twisting loads resulting
      from free moments. Coefficients of friction and free moments should be considered
      for future longitudinal studies to investigate potential cause-effect
      relationships among footwear, potential for injury, and dance performance.

PMID- 29843887
TI  - Pain and Injury in Elite Adolescent Irish Dancers: A Cross-Sectional Study.
AB  - Dance is an extremely popular activity among adolescents and has a range of
      associated physical and psychological health benefits. However, pain and injury
      in young elite dancers is pervasive, and the underlying risk factors are poorly
      understood. This study investigated the incidence of pain and injury in elite
      adolescent Irish dancers and examined a range of potentially associated
      biopsychosocial risk factors. Thirty-seven championship level Irish dancers
      completed baseline questionnaires recording any episode of pain or injury over
      the previous 12 months. Additionally, dancers provided information regarding
      their dance practices, general health, sleep, eating habits, and a range of
      psychological factors including mood, catastrophizing, passion for dance, and
      achievement motivation. A baseline physical screening protocol including
      assessment of balance, fitness, flexibility, endurance, and functional movement
      was conducted. Subjects were separated into a "more pain and injury (MPI)" group
      (N = 17) or "less pain and injury (LPI)" group (N = 20) based on their reported
      pain and injury history over the previous year. Statistical analysis was
      conducted using independent samples ttest, the Mann-Whitney U test for skewed
      variables, and the test of independence for categorical variables as appropriate.
      Eighty-four percent of subjects recorded at least one pain or injury during the
      previous year. The lower limb, particularly the foot and ankle, was most commonly
      affected. Factors significantly associated with pain and injury included having
      an unusual number of troublesome body parts (p = 0.002), often or always dancing
      in pain (p = 0.033), and high levels of anger or hostility (p = 0.045). This
      study demonstrates that elite adolescent Irish dance is associated with a
      substantial risk of pain and injury that appears to be greater than that incurred
      by young dancers from other genres. Proposed explanations include inappropriate
      technique progression, unique choreographic features, and an overly arduous
      calendar of competitive events. A prospective study nearing completion will help
      clarify causal factors in these dancers.

PMID- 29843888
TI  - Shame and Anxiety: The Mediating Role of Childhood Adversity in Dancers.
AB  - The combination of shame, anxiety, and a history of childhood maltreatment can
      have devastating effects on self-esteem and on the morbidity and mortality of an
      individual. Shame is a natural emotion evoked in social evaluative settings.
      Without some degree of shame, goal attainment is less likely. However, high
      levels of shame may increase pathology and decrease performance. In this
      crosssectional study, pre-professional and professional dancers were divided into
      two shame groupings: low (N = 193) and high (N = 25). Chi square and multivariate
      analyses of covariance (age and gender as covariates) were conducted to determine
      group differences for cumulative adverse childhood experiences (ACEs), anxiety,
      self-esteem, and shame factors. The high shame group had a greater distribution
      of childhood adversity (especially emotional, physical and sexual abuse, and
      emotional neglect). They also had clinical levels of anxiety and low self-esteem.
      In the path analyses, the causal model demonstrated that childhood adversity had
      a direct effect on anxiety and shame and an indirect effect on self-esteem. Shame
      and anxiety had a direct effect on self-esteem. Helping dancers become resistant
      to shame may decrease anxiety and buffer the effects of a history of childhood
      adversity. As internalized shame decreases, dancers may enhance their self
      esteem, wellbeing, and ability to pursue and achieve their career goals.

PMID- 29843891
TI  - The effect of elevated non-esterified fatty acid concentrations on bovine
      spermatozoa and on oocyte invitro fertilisation.
AB  - Elevated non-esterified fatty acid (NEFA) concentrations, present in follicular
      and oviductal fluid, have been postulated as a causative link between metabolic
      disorders and subfertility. High NEFA conditions can directly disrupt oocyte
      maturation and developmental capacity after fertilisation. However, their
      influence on sperm function and the fertilisation process is not known. This
      study investigated the fertilisation process under high NEFA conditions. To
      differentiate between effects on both spermatozoa and oocytes or on spermatozoa
      only, different experiments were conducted. In the first experiment both gametes
      were simultaneously incubated during IVF under different conditions: (1) NEFA
      free, solvent-free control conditions, (2) solvent control, (3) physiological
      concentrations of oleic (OA), palmitic (PA) and stearic (SA) acids or (4)
      pathophysiological concentrations of OA, PA and SA. In the second experiment
      spermatozoa were incubated (4h) under the same treatment conditions prior to
      routine IVF. Gamete co-incubation resulted in reduced fertilisation and cleavage
      rates and increased prevalence of polyspermy. In the second experiment embryo
      developmental capacity and quality were not affected, although sperm motility and
      plasma membrane integrity were decreased. In conclusion, lipolytic conditions
      affected the fertilisation process mainly through an effect on the oocyte.
      Spermatozoa were still able to fertilise even though these conditions reduced
      sperm function.

PMID- 29843892
TI  - Insulin-like growth factor-1 (IGF-1) promotes primordial follicle growth and
      reduces DNA fragmentation through the phosphatidylinositol 3-kinase/protein
      kinase B (PI3K/AKT) signalling pathway.
AB  - We investigated the effects of insulin-like growth factor 1 (IGF-1) on the
      morphology and follicular activation of ovine preantral follicles cultured in
      situ and whether the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT)
      pathway is involved in IGF-1 action in the sheep ovary. Ovine ovarian fragments
      were fixed for histological and terminal deoxynucleotidyl transferase dUTP nick
      end labelling (TUNEL) analyses (fresh control) or cultured in supplemented alpha
      minimum essential medium (alpha-MEM+; control) or alpha-MEM+ with IGF-1 (1, 10,
      50, 100 or 200ngmL-1) for 7 days. Follicles were classified as normal or atretic,
      primordial or growing and the oocyte and follicle diameters were measured. DNA
      fragmentation was evaluated by TUNEL assay. Proliferating cell nuclear antigen
      (PCNA) immunohistochemistry was performed on the fresh control, alpha-MEM+ and
      100ngmL-1 IGF-1 samples. Inhibition of PI3K activity was performed through
      pretreatment with the PI3K inhibitor LY294002 and phosphorylated AKT (pAKT)
      expression was analysed after culture in the absence or presence of LY294002. IGF
      1 at 100ngmL-1 increased (P<0.05) follicular activation compared with alpha-MEM+
      and decreased TUNEL-positive cells (P<0.05) compared with other treatments. PCNA
      positive cells also increased (P<0.05) in 100ngmL-1 IGF-1. LY294002 significantly
      inhibited follicular activation stimulated by alpha-MEM+ and 100ngmL-1 IGF-1 and
      reduced pAKT expression in follicles. Overall, IGF-1 at 100ngmL-1 promoted
      primordial follicle activation, cell proliferation and reduced DNA fragmentation
      after in situ culture through the PI3K/AKT pathway.

PMID- 29843893
TI  - Boar sperm hyperactivated motility is induced by temperature via an intracellular
      calcium-dependent pathway.
AB  - Herein we describe a new protocol to induce boar sperm hypermotility: temperature
      induced hypermotility (TIH). Briefly, spermatozoa stored at 17 degrees C in a
      calcium-free Tyrode's basal medium (containing EGTA) were exposed to increased
      temperature by incubation at 38.5 degrees C. Hypermotility induced by the calcium
      ionophore A23187 was used as a control (calcium ionophore-induced hyperactivity
      (CIIH)). The increase in temperature led to an increase in the percentage of
      hypermotile spermatozoa. When the slope of the temperature increase is near zero,
      sperm hyperactivity becomes a more progressive movement. Motility parameters of
      sperm hyperactivation induced by TIH were different from those following CIIH.
      Cluster analysis revealed that these two populations of hyperactivated
      spermatozoa are different. TIH is independent of extracellular Ca2+ but dependent
      on intracellular Ca2+ release. Moreover, TIH is unaffected by protein kinase A
      (PKA) inhibition, whereas CIIH is reduced by half in the presence of a PKA
      inhibitor. In conclusion, we have demonstrated that: (1) a temperature increase
      in boar spermatozoa is a stimulus that can induce a hyperactive population, which
      is differs from the hyperactive sperm population induced by calcium ionophore;
      (2) the temperature increase in spermatozoa triggers the release of Ca2+ from
      intracellular stores; (3) extracellular calcium is not required for TIH; and (4)
      TIH in boar spermatozoa is independent of PKA activity.

PMID- 29843894
TI  - Diffuse Erythema and Acral Hyperkeratosis in a Newborn.

PMID- 29843895
TI  - Single versus double column fixation in transverse fractures of the acetabulum: A
      randomised controlled trial.
AB  - INTRODUCTION: Biomechanical studies have compared fixation methods in transverse
      acetabular fractures, yet there is not enough clinical data to suggest an optimal
      fixation method. The aim of this randomized controlled trail was to compare
      fracture stability in posterior plating alone versus posterior plating and
      anterior column lag-screw fixation in treatment of transverse and transverse with
      posterior wall acetabular fractures. METHODS: Thirty patients were randomized to
      one of two groups, either posterior fixation alone (single column group), or
      posterior plating and anterior fixation with percutaneous anterior column screw
      (double column group). Patients were followed up with serial radiographic
      assessments documenting any loss of reduction, utilizing Matta's radiological
      criteria, measuring the roof arc angles and by measuring any change in the
      femoral head offset. RESULTS: Fifteen patients were randomized to each group.
      Mean patient age was 31 years, mean follow up period was 19 months (range 12-24).
      There was no significant differences between the two groups with regards the
      quality of post-operative reduction, blood loss, hospital stay and functional
      score using the modified Merle D'Aubinge and Postel score. The operative time was
      significantly longer in the double column fixation group (130 min versus 104
      min). There was no loss of reduction observed in either of the two groups.
      CONCLUSION: Single poster column fixation in transverse and transverse posterior
      wall fractures showed similar result to double column fixation, in terms of
      fractures stability in the follow up period, quality of reduction and early
      functional outcome.

PMID- 29843896
TI  - Episodic memory for natural and transformed food.
AB  - It has been proposed that the conceptual knowledge of food and its putative
      subdivision into natural (i.e., fruit/vegetables) and transformed (i.e., food
      that underwent thermic or non-thermic processing) may follow the living/non
      living distinction. In the present study, we investigated whether the advantage
      for living things compared to non-living things observed in episodic memory (the
      so-called animacy effect) extends to natural foods and transformed foods
      respectively. We pursued this issue in two experiments. In Experiment 1, we
      measured episodic memory for natural and transformed foods in young participants.
      In Experiment 2, we enrolled dementia-free centenarians, patients with
      Alzheimer's disease (DAT), Progressive primary aphasia (PPA), and healthy
      controls whose episodic memory was also tested for living/non-living things.
      Results showed that young participants had better recognition memory for
      transformed foods compared to natural foods. This difference disappeared in
      centenarians and patients. However, centenarians and PPA exhibited enhanced
      levels of false alarms (FA) with natural food, and DAT patients with both natural
      and transformed food. As far as the living/non-living distinction is concerned,
      the episodic memory for the living category appears more resilient to the decline
      compared to the non-living category in patients, particularly those with PPA. In
      conclusion, our study shows that transformed food is better remembered than
      natural food, suggesting that it is more salient and possibly relevant from an
      evolutionary perspective. The natural/transformed distinction appears susceptible
      to erosion only in the presence of a high degree of episodic memory impairment.
      These results offer novel insight on episodic memory of food, and also extend the
      current knowledge on the animacy effect in episodic memory.

PMID- 29843897
TI  - Major bleeding with old and novel oral anticoagulants: How to manage it. Focus on
      reversal agents.
AB  - Even though vitamin K antagonists (VKAs) have been employed for >50 years, there
      is still some uncertainty about the best strategy to reverse anticoagulation due
      to VKAs in cases of major bleeding. Furthermore, there is also scarce evidence
      about the most appropriate way to treat serious bleeding associated with non
      vitamin K antagonist oral anticoagulants. This review analyses the main
      advantages and disadvantages of the various forthcoming therapeutic options to
      restore a normal coagulation status in anticoagulated patients with ongoing
      serious bleeding. It discusses the role of fresh frozen plasma, prothrombin
      complex concentrates and recombinant factor VII activated. Moreover, we report
      updated evidence on antidotes currently available or in development. Finally,
      this article proposes a comprehensive algorithm that summarizes major bleeding
      management during treatment with oral anticoagulants.

PMID- 29843898
TI  - Association of ibuprofen use with post-tonsillectomy bleeding in older children.
AB  - OBJECTIVE: Evaluate post-tonsillectomy outcomes in children discharged with
      ibuprofen versus those without. METHODS: This was a retrospective review of
      children who underwent tonsillectomy +/- adenoidectomy from 2012 to 2016 at a
      tertiary care children's hospital. Main outcome measures included bleed rates, ER
      visits, and nurse phone calls. RESULTS: Seven hundred and seventy-three patients
      were included; 504 had ibuprofen at discharge (ID) and 269 did not (NID). There
      were significant differences in mean age, 6.7 years in the ID group years versus
      8.6 for the NID group (P < 0.001). Indication for surgery was sleep apnea in
      70.5% of ID patients and 44.0% of NID patients (P < 0.001). Post-tonsillectomy
      bleeds occurred in 8.7% in the ID group and 5.9% of the NID group (P = 0.168).
      Other outcome measures revealed no significant differences between the two
      groups. There was no significant difference in the outcome measures between
      patients with sleep apnea or recurrent tonsillitis. Age was important; 12.1% of
      children 9-18 years versus 4.8% in children 3.1-6 years (P = 0.006) had post
      tonsillectomy bleeding. For children 9-18 years old, 16.7% in the ID group bled
      versus 7.5% in the NID group (P = 0.039). Logistical regression revealed that age
      contributed to post-op bleeding, and ibuprofen contributed to number of ER
      visits. CONCLUSION: Ibuprofen is associated with significantly elevated post
      tonsillectomy bleeding in older children, further research is needed and other
      analgesics should be considered.

PMID- 29843899
TI  - Randomized phase II trial evaluating pain response in patients with spinal
      metastases following stereotactic body radiotherapy versus three-dimensional
      conformal radiotherapy.
AB  - BACKGROUND: To report the primary endpoint of a randomized trial comparing pain
      response following palliative stereotactic body radiation therapy (SBRT) versus
      conventionally-fractionated 3D-conformal radiotherapy (3DCRT) for previously
      untreated spinal metastases. METHODS: Fifty-five patients with
      histologically/radiologically confirmed painful spinal metastases were analyzed
      in this single-institutional, non-blinded, randomized explorative trial.
      Participants were randomly assigned (1:1) to receive single-fraction SBRT (24 Gy)
      or 3DCRT (30 Gy in 10 fractions). The primary endpoint was pain relief of >2
      points on the visual analog scale (VAS) measured within the irradiated region at
      3 months following radiotherapy completion. Other recorded parameters included
      pain response (per International Bone Consensus response definitions), use of
      concurrent medications and opioid usage (oral morphine equivalent dose, OMED).
      All parameters were assessed at baseline and at three and six months after RT.
      Intention-to-treat analysis was applied. This trial is registered with
      ClinicalTrials.gov, number NCT02358720. FINDINGS: Despite no significant
      differences for VAS at 3 months between groups (p = 0.13), pain values decreased
      faster within this time period in the SBRT arm (p = 0.01). At 6 months following
      RT, significantly lower VAS values were reported in the SBRT group (p = 0.002).
      There were no differences in OMED consumption at 3 (p = 0.761) and 6 months (p =
      0.174). There was a trend toward improved pain response in the SBRT arm at 3
      months (p = 0.057), but significantly so after 6 months (p = 0.003). No patient
      in the SBRT group experienced grade >=3 toxicities according to the Common
      Terminology Criteria for Adverse Events v.4.03. CONCLUSIONS: This randomized
      trial demonstrates the utility of palliative SBRT for spinal metastases, which
      was associated with a quicker and improved pain response. Larger ongoing
      randomized studies will assist in further addressing these endpoints.

PMID- 29843900
TI  - Serum 25-hydroxyvitamin D level is negatively associated with serum phosphorus
      level among stage 3a-5 chronic kidney disease patients.
AB  - BACKGROUND: Serum 25-hydroxyvitamin D (25(OH)D) negatively correlates with serum
      phosphorus level of stage 3a-5 chronic kidney disease (CKD) patients. So far, no
      explanation has been provided for this negative association. OBJECTIVE: To
      confirm this negative association and determine if this relationship is mediated
      through other known co-morbid factors. CASES AND METHODS: One hundred (57 male
      and 43 female) pre-dialysis stage 3a-5 CKD patients were selected. Estimated
      glomerular filtration rate (eGFR), serum calcium (Ca), phosphorus (P), 25(OH)D,
      parathyroid hormone (PTH), and intact fibroblast growth factor-23 (FGF23) were
      assessed. A correlation analysis between serum 25(OH)D and the different
      parameters studied was performed. Multivariate linear regression analysis was
      carried out to determine predictors of 25(OH)D. RESULTS: The negative association
      between serum 25(OH)D and serum P was confirmed in univariate and multivariate
      correlation analysis. On the other hand, we failed to detect a significant
      association between 25(OH)D and serum FGF23. Serum P is the most important
      independent predictor of 25(OH)D in these patients (partial R2=0.15, p<0.0001).
      CONCLUSION: Serum P is likely to have a direct negative impact on serum 25(OH)D.
      Further studies are needed to determine the underlying mechanism.

PMID- 29843901
TI  - Slaintecare - A ten-year plan to achieve universal healthcare in Ireland.
AB  - In May 2017, an Irish cross-party parliamentary committee published the 'Houses
      of the Oireachtas Committee on the Future of Healthcare "Slaintecare" report'.
      The report, known as 'Slaintecare', is unique and historic as it is the first
      time there has been a cross-party political consensus on major health reform in
      Ireland. Slaintecare sets out a high level policy roadmap to deliver whole system
      reform and universal healthcare, phased over a ten year period and costed.
      Slaintecare details reform proposals which, if delivered, will establish; a
      universal, single-tier health service where patients are treated solely on the
      basis of health need; the reorientation of the health system 'towards integrated
      primary and community care, consistent with the highest quality of patient safety
      in as short a time-frame as possible'. Slaintecare has five interrelated
      components: population health; entitlements and access to healthcare; integrated
      care; funding; and implementation. In this article, the authors use documents in
      the public domain (parliamentary reports, public hearings, submissions to the
      Committee, media coverage, the final report of the Committee, speeches by
      Committee members) to describe the policy process and the main contents of the
      proposed Slaintecare reforms. It is too soon tell if the political consensus in
      the policy formation can hold for its implementation.

PMID- 29843902
TI  - Non-inflammatory causes of emergency consultation in patients with multiple
      sclerosis.
AB  - OBJECTIVES: To describe non-relapse-related emergency consultations of patients
      with multiple sclerosis (MS): causes, difficulties in the diagnosis, clinical
      characteristics, and treatments administered. METHODS: We performed a
      retrospective study of patients who attended a multiple sclerosis day hospital
      due to suspected relapse and received an alternative diagnosis, over a 2-year
      period. Demographic data, clinical characteristics, final diagnosis, and
      treatments administered were evaluated. Patients who were initially diagnosed
      with pseudo-relapse and ultimately diagnosed with true relapse were evaluated
      specifically. As an exploratory analysis, patients who consulted with non
      inflammatory causes were compared with a randomly selected cohort of patients
      with true relapses who attended the centre in the same period. RESULTS: The study
      included 50 patients (33 were women; mean age 41.4+/-11.7years). Four patients
      (8%) were initially diagnosed with pseudo-relapse and later diagnosed as having a
      true relapse. Fever and vertigo were the main confounding factors. The non
      inflammatory causes of emergency consultation were: neurological, 43.5% (20
      patients); infectious, 15.2% (7); psychiatric, 10.9% (5); vertigo, 8.6% (4);
      trauma, 10.9% (5); and miscellaneous, 10.9% (5). CONCLUSIONS: MS-related symptoms
      constituted the most frequent cause of non-inflammatory emergency consultations.
      Close follow-up of relapse and pseudo-relapse is necessary to detect incorrect
      initial diagnoses, avoid unnecessary treatments, and relieve patients' symptoms.

PMID- 29843903
TI  - Second neoplasms in patients infected with HIV.

PMID- 29843904
TI  - Predicting adhesion and biofilm formation boundaries on stainless steel surfaces
      by five Salmonella enterica strains belonging to different serovars as a function
      of pH, temperature and NaCl concentration.
AB  - This study aimed to assess the capability of 97 epidemic S. enterica strains
      belonging to 18 serovars to form biofilm. Five strains characterized as strong
      biofilm-producers, belonging to distinct serovars (S. Enteritidis 132, S.
      Infantis 176, S. Typhimurium 177, S. Heidelberg 281 and S. Corvallis 297) were
      assayed for adhesion/biofilm formation on stainless steel surfaces. The
      experiments were conducted in different combinations of NaCl (0, 2, 4, 5, 6, 8
      and 10% w/v), pH (4, 5, 6 and 7) and temperatures (8  degrees C, 12  degrees C,
      20  degrees C and 35  degrees C). Only adhesion was assumed to occur when S.
      enterica counts were >=3 and <5 log CFU/cm2, whereas biofilm formation was
      defined as when the counts were >=5 log CFU/cm2. The binary responses were used
      to develop models to predict the probability of adhesion/biofilm formation on
      stainless steel surfaces by five strains belonging to different S. enterica
      serovars. A total of 99% (96/97) of the tested S. enterica strains were
      characterized as biofilm-producers in the microtiter plate assays. The ability to
      form biofilm varied (P < 0.05) within and among the different serovars. Among the
      biofilm-producers, 21% (20/96), 45% (43/96), and 35% (34/96) were weak, moderate
      and strong biofilm-producers, respectively. The capability for adhesion/biofilm
      formation on stainless steel surfaces under the experimental conditions studied
      varied among the strains studied, and distinct secondary models were obtained to
      describe the behavior of the five S. enterica tested. All strains showed adhesion
      at pH 4 up to 4% of NaCl and at 20  degrees C and 35  degrees C. The probability
      of adhesion decreased when NaCl concentrations were >8% and at 8  degrees C, as
      well as in pH values <= 5 and NaCl concentrations > 6%, for all tested strains.
      At pH 7 and 6, biofilm formation for S. Enteritidis, S. Infantis, S. Typhimurium,
      S. Heidelberg was observed up to 6% of NaCl at 35  degrees C and 20  degrees C.
      The predicted boundaries for adhesion were pH values < 5 and NaCl >= 4% and at
      temperatures <20  degrees C. For biofilm formation, the predicted boundaries were
      pH values < 5 and NaCl concentrations >= 2% and at temperatures <20  degrees C
      for all strains. The secondary models obtained describe the variability in
      boundaries of adhesion and biofilm formation on stainless steel by five strains
      belonging to different S. enterica serovars. The boundary models can be used to
      predict adhesion and biofilm formation ability on stainless steel by S. enterica
      as affected by pH, NaCl and temperature.

PMID- 29843905
TI  - Real-world data on antiviral treatments for hepatitis C virus infections: Can we
      define intention to treat or per protocol analyses?

PMID- 29843906
TI  - Endometrial cancer: Molecular markers and management of advanced stage disease.
AB  - Endometrial cancer is the most prevalent gynecologic cancer in the United States.
      Over the last 10 years, death rates from endometrial cancer have been rising
      about 1.4% per year. Traditionally endometrial cancer treatment has been driven
      by stage and histology. Recent studies have, however, shown that cancers of the
      same stage and histology have very distinct molecular and genomic profiles.
      Translational research is progressing rapidly and endometrial cancer-specific
      precision medicine is evolving. The first tissue agnostic therapy based on the
      molecular profile of the tumor was approved by the FDA this year. The approval of
      immune checkpoint inhibitor, pembrolizumab (anti-PD-1), for all solid tumors with
      defective DNA mismatch repair, could benefit 20-30% of patients with advanced
      endometrial cancer. Other genomic changes and molecular markers in endometrial
      cancer, such as hormone receptor status, could lead to more tailored therapy in
      the future. Pre-clinical and clinical investigations of targeted therapies
      suggest efficacy for some agents. Single agent targeted therapies, however, have
      modest activity. Identifying biomarkers that effectively determine response to
      targeted therapy remains a challenge. The next generation of clinical trials will
      focus on novel combinations and how to best utilize the advances that have been
      made in sequencing technology and bioinformatics. Although there is currently an
      immense body of data and many options for obtaining genomic characteristics of
      endometrial cancer, how to interpret and utilize this data is still being
      explored. This review will summarize the important trials that have led to the
      treatment options we have for advanced and/or recurrent endometrial cancer and
      discuss the important studies that have led to a better understanding of the
      distinctive molecular and genomic profiles within endometrial cancer. We will
      review the current status of biomarker-driven targeted therapy in endometrial
      cancer and the rationale behind ongoing clinical trials that are utilizing novel
      targeted agents.

PMID- 29843907
TI  - Abdominal stab wound injury in children: Do we need different approach?
AB  - BACKGROUND: Penetrating stab wounds in children are relatively rare and no clear
      recommendations for the optimal evaluation have been devised. An acceptable
      traditional approach to the patient with an abdominal stab wound who does not
      require urgent surgery is selective nonoperative management and serial exams. The
      use of routine computed tomography remains an actively utilized investigation for
      these patients at many institutions. PURPOSE: We hypothesize that the approach to
      pediatric stab wound victims should be distinctly different than that of adult
      counterparts in order to minimize radiation exposure. METHODS: A retrospective
      cohort study involving abdominal stab wounds among pediatric trauma patients (age
      < 14) compared with adults between the years 1997 and 2016 was conducted
      utilizing the Israeli National Trauma Registry. RESULTS: A total of 92 children
      and 4444 adults were identified from the registry for inclusion. Among the
      children 20 (21.7%) patients had intraabdominal injury compared to 1730 (38.9%)
      among adult counterparts. Four children were hemodynamically unstable, two of
      them were referred directly to operating room and two others were treated without
      surgery. Among the remaining 88 children there was no observed mortality.
      CONCLUSIONS: The majority of pediatric stab wounds trauma victims have minor
      abdominal injuries. We do not recommend the routine utilization of abdominal CT
      scan in the evaluation of abdominal stab wounds. Observation with serial exams
      and minimization of radiation exposure from CT are warranted in this unique
      population. TYPE OF STUDY: Retrospective comparative study. LEVEL OF EVIDENCE: 3.

PMID- 29843908
TI  - Malnutrition increases the risk of 30-day complications after surgery in
      pediatric patients with Crohn disease.
AB  - BACKGROUND: Pediatric patients with Crohn disease (CD) are frequently
      malnourished, yet how this affects surgical outcomes has not been evaluated. This
      study aims to determine the effects of malnourishment in children with CD on 30
      day outcomes after surgery. STUDY DESIGN: The ACS NSQIP-Pediatric database from
      2012 to 2015 was used to select children aged 5-18 with CD who underwent bowel
      surgery. BMI-for-age Z-scores were calculated based on CDC growth charts and 2015
      guidelines of pediatric malnutrition were applied to categorize severity of
      malnutrition into none, mild, moderate, or severe. Malnutrition's effects on 30
      day complications. Propensity weighted multivariable regression was used to
      determine the effect of malnutrition on complications were evaluated. RESULTS:
      516 patients were included: 349 (67.6%) without malnutrition, 97 (18.8%) with
      mild, 49 (9.5%) with moderate, and 21 (4.1%) with severe malnutrition. There were
      no differences in demographics, ASA class, or elective/urgent case type. Overall
      complication rate was 13.6% with malnutrition correlating to higher rates: none
      9.7%, mild 18.6%, moderate 20.4%, and severe 28.6% (p < 0.01). In propensity
      matched, multivariable analysis, malnutrition corresponded with increased odds of
      complications in mild and severely malnourished patients (mild OR = 2.1 [p =
      0.04], severe OR 3.26 [p = 0.03]). CONCLUSION: Worsening degrees of malnutrition
      directly correlate with increasing risk of 30-day complications in children with
      CD undergoing major bowel surgery. These findings support BMI for-age z scores as
      an important screening tool for preoperatively identifying pediatric CD patients
      at increased risk for postoperative complications. Moreover, these scores can
      guide nutritional optimization efforts prior to elective surgery. LEVEL OF
      EVIDENCE: IV.

PMID- 29843909
TI  - Molluscan indicator species and their potential use in ecological status
      assessment using species distribution modeling.
AB  - Marine habitat assessment using indicator species through Species Distribution
      Modeling (SDM) was investigated. The bivalves: Corbula gibba and Flexopecten
      hyalinus were the indicator species characterizing disturbed and undisturbed
      areas respectively in terms of chlorophyll a concentration in Greece. The habitat
      suitability maps of these species reflected the overall ecological status of the
      area. The C. gibba model successfully predicted the occurrence of this species in
      areas with increased physical disturbance driven by chlorophyll a concentration,
      whereas the habitat map for F. hyalinus showed an increased probability of
      occurrence in chlorophyll-poor areas, affected mainly by salinity. We advocate
      the use of C. gibba as a proxy for eutrophication and the incorporation of this
      species in monitoring studies through SDM methods. For the Mediterranean Sea we
      suggest the use of F. hyalinus in SDM as an indicator of environmental stability
      and a possible forecasting tool for salinity fluctuations.

PMID- 29843910
TI  - Impact of inadvertent enterotomy on short-term outcomes after ventral hernia
      repair: An AHSQC analysis.
AB  - BACKGROUND: Patients undergoing ventral hernia repair (VHR) are at risk of an
      inadvertent enterotomy during surgery. Inadvertent enterotomies potentially
      contaminate the surgical field presenting a management dilemma for the surgeon.
      The aim of our study was to define the incidence and risk factors for a
      recognized inadvertent enterotomy and determine its impact on short-term outcomes
      after ventral hernia repair. METHODS: Using a nationwide hernia registry, the
      Americas Hernia Society Quality Collaborative, we reviewed all ventral hernia
      repair performed between 2013 and 2017. Patients were assessed for full-thickness
      inadvertent enterotomies at the time of surgery. Patients with inadvertent
      enterotomies and without enterotomies were compared to assess differences in 30
      day outcomes, using regression modeling. RESULTS: A total of 5,916 patients were
      included. The incidence of inadvertent enterotomy was 1.9%, with no difference
      between open and laparoscopic approaches. Inadvertent enterotomies did not
      increase surgical site occurrences but there were more surgical site infections
      (OR: 2.20 [95% CI: 1.24-3.90], P = .007). Patients were less likely to receive
      mesh if there was an enterotomy. Inadvertent enterotomies led to higher rates of
      reoperations, readmission, enterocutaneous fistulas, and mortality. CONCLUSION:
      Inadvertent enterotomies are more common in complex cases of ventral hernia
      repair and have an overall incidence of 1.9%. These patients are at increased
      risk of surgical site infections, reoperations, readmission, and mortality.
      Although definitive hernia repair with mesh can be safely performed, surgeons
      should consider multiple factors, including type of mesh and location of mesh in
      the abdominal wall, before proceeding with definitive repair in any case of an
      enterotomy.

PMID- 29843911
TI  - Reconsideration of tumor size threshold for total thyroidectomy in differentiated
      thyroid cancer.
AB  - BACKGROUND: The optimal extent of surgery for differentiated thyroid cancer may
      not be well recognized initially. Identification of intermediate-risk features on
      surgical pathology may prompt the need for completion thyroidectomy if a
      lobectomy is performed. In this study, we examined the factors in relation to the
      need for completion thyroidectomy. METHODS: We studied consecutive patients who
      underwent thyroidectomy for differentiated thyroid cancer from 2008 to 2017.
      Total thyroidectomy was indicated when tumor size >4 cm, clinical extrathyroidal
      extension, clinical lymph node metastasis, or distant metastasis was present. The
      need for completion thyroidectomy was defined as the presence of aggressive
      histology, extrathyroidal extension, lymphovascular invasion, or non-low-risk
      nodal metastasis. RESULTS: Among 771 patients, 155 (20%) were definitely
      indicated for total thyroidectomy. The need for completion thyroidectomy was
      identified in 273 (44%) of the 616 patients initially eligible for lobectomy. The
      proportions of patients requiring completion thyroidectomy were 18% and 57% for
      microcarcinomas and tumors of 1-4 cm, respectively. Receiver operating
      characteristic curve analysis indicated that tumor size >=1.1 cm had the highest
      accuracy of prediction. Multivariate logistic regression revealed that tumor size
      and BRAF V600E mutation were independent factors predicting the risk of requiring
      completion thyroidectomy. CONCLUSION: A substantial portion of patients with
      differentiated thyroid cancer who are preoperatively eligible for lobectomy would
      be found to have intermediate-risk pathologic features. This should be
      incorporated into the shared decision making before surgery.

PMID- 29843912
TI  - Association Between Utilization of Chiropractic Services for Treatment of Low
      Back Pain and Risk of Adverse Drug Events.
AB  - OBJECTIVES: Mortality rates due to adverse drug events (ADEs) are escalating in
      the United States. Analgesics are among the drug classes most often associated
      with occurrence of an ADE. Utilization of nonpharmacologic chiropractic services
      for treatment of low back pain could lead to reduced risk of an ADE. The
      objective of this investigation was to evaluate the association between
      utilization of chiropractic services and likelihood of an ADE. METHODS: We
      employed a retrospective cohort design to analyze health insurance claims data
      from the state of New Hampshire. After inversely weighting each participant by
      their propensity to be in their cohort, we employed logistic regression to
      compare recipients of chiropractic services to nonrecipients with regard to
      likelihood of occurrence of an ADE in an outpatient setting. RESULTS: The risk of
      an ADE was significantly lower among recipients of chiropractic services as
      compared with nonrecipients. The adjusted likelihood of an ADE occurring in an
      outpatient setting within 12 months was 51% lower among recipients of
      chiropractic services as compared to nonrecipients (OR 0.49; P = .0002). The
      reported ADEs were nonspecific with regard to drug category in the majority of
      incidents that occurred in both cohorts. CONCLUSIONS: Among New Hampshire adults
      with office visits for low back pain, the adjusted likelihood of an ADE was
      significantly lower for recipients of chiropractic services as compared to
      nonrecipients. No causal relationship was established between utilization of
      chiropractic care and risk of an ADE. Future research should employ larger
      databases, rigorous methods to reduce risk of bias, and more sensitive means of
      identifying ADEs.

PMID- 29843913
TI  - Controversial points in the obesity paradox in patients with coronary artery
      disease.

PMID- 29843914
TI  - Escaping the atherogenic trap: Preventing LDL fusion and binding in the intima.

PMID- 29843916
TI  - Reply to: "Anthropometric measures in the risk assessment of obese individuals".

PMID- 29843915
TI  - Update on peripheral artery disease: Epidemiology and evidence-based facts.

PMID- 29843917
TI  - Nationwide cohort study of mitral valve repair versus replacement for infective
      endocarditis.
AB  - OBJECTIVES: The feasibility and long-term outcomes of mitral valve (MV) repair in
      patients with infective endocarditis (IE) remain unclear. METHODS: Using Taiwan's
      National Health Insurance Research Database, we identified 1999 patients who
      underwent MV surgery for IE during 2000 to 2013. The patients were more likely to
      have undergone valve replacement (1575 patients; 78.8%) than valve repair (424
      patients; 21.2%). After 1:1 propensity score matching, 352 patients in each group
      were included for analysis. Perioperative outcomes and late composite end points,
      comprising all-cause mortality, MV reoperation, any stroke, major bleeding, and
      readmission for heart failure, were compared. RESULTS: Patients who received MV
      repair had fewer perioperative complications, lower in-hospital mortality rates
      (6.3% vs 10.8%; P = .031), and lower risks of late mortality (hazard ratio [HR],
      0.59; 95% confidence interval [CI], 0.44-0.80), and composite end point (HR,
      0.67; 95% CI, 0.52-0.87) during a mean follow-up of 4.8 years. Subgroup analysis
      revealed a trend in which the beneficial effect of MV repair was not apparent
      when surgeries were performed in hospitals within the lowest volume quartile (P
      for interaction = .091). In patients who underwent surgery during active IE, MV
      repair was also related to a lower rate of late mortality (HR, 0.64; 95% CI, 0.48
      0.85). CONCLUSIONS: Mitral repair for IE has better perioperative and late
      outcomes than mitral replacement. Mitral repair performed by an experienced team
      is recommended for IE patients instead of MV replacement whenever possible, even
      with an active infection status.

PMID- 29843918
TI  - Prevalence and correlates of bleeding and emotional harms in a national US sample
      of patients with venous thromboembolism: A cross-sectional structural equation
      model.
AB  - INTRODUCTION: Venous thromboembolism (VTE) including deep vein thrombosis (DVT)
      or pulmonary embolism (PE) is associated with reduced survival, poorer quality of
      life, and substantial health-care-costs. Limited research, primarily qualitative,
      suggests that those with VTE may have elevated fear of recurrence, and associated
      emotional dysfunction and distress. METHODS: A national online survey was
      administered to 907 patients who had experienced a VTE event in the past two
      years. The survey assessed for the prevalence of self-reported bleeding harms
      associated with VTE, the levels of anxiety, depression, cognitive dysfunction and
      distress experienced by patients, and a range of potential psychosocial
      correlates that may be associated with these bleeding or emotional harms.
      RESULTS: The majority (63.0%) of respondents had experienced at least one
      bleeding related harm following their VTE diagnosis, and 40.6% indicated they
      experienced fear of another clot often or almost all the time. One-in-four
      (24.7%) and one-in-ten (11.6%) had abnormal levels of anxiety and depression,
      respectively. Structural equation modeling was used to define two composite
      latent bleeding harm and emotional harm factors. Emotional and bleeding harms
      were associated with younger age, a belief that one's health is due to luck,
      having multiple comorbidities, having a history of prior VTE events, having
      multiple barriers to VTE care, and experiencing medical mistakes in diagnosis or
      treatment. Emotional harms were uniquely predicted by having poorer health
      literacy, having low self-reported medication adherence, belief others are
      responsible for one's health, and more recent VTE events. Bleeding harms were
      uniquely predicted by having a lower frequency of primary care provider contact
      and having a history of switching between warfarin and direct oral anticoagulants
      for VTE treatment. CONCLUSIONS: The findings show high levels of self-reported
      bleeding and emotional harms in a general population of VTE sufferers that are
      clearly associated with readily identifiable demographic, health status, and
      psychosocial characteristics. These represent targets for intervention and
      changes in clinical practice.

PMID- 29843919
TI  - Morphometry and hemodynamics of posterior communicating artery aneurysms:
      Ruptured versus unruptured.
AB  - Posterior communicating artery (PCoA) aneurysms frequently rupture in small size
      (<7 mm). The aim of the study is to demonstrate morphometric and hemodynamic
      analyses in ruptured and unruptured PCoA aneurysms to improve predictive accuracy
      for rupture. Geometrical models were reconstructed from rotational DSA images of
      57 ruptured and 22 unruptured side-wall PCoA aneurysms, which were classified
      into four two-dimensional (2D) groups by a combination of H/D and H/S ratios (H:
      dome height, D: dome diameter, and S: semi-axis height). Surface area ratio (SAR)
      of low time-averaged wall shear stress (TAWSS, <=4 dynes cm-2) and high
      oscillatory shear index (OSI, >=0.15) were computed in aneurysms. We hypothesized
      that a two-step analysis method, i.e., one-dimensionally morphometric and
      hemodynamic analyses in each 2D group, can enhance accuracy of PCoA aneurysm
      rupture evaluation. There was the highest incidence of H/D > 1 and H/S <= 2 with
      the largest surface area and SAR-TAWSS, but the lowest incidence of H/D <= 1 and
      H/S > 2 with the smallest surface area and SAR-TAWSS in ruptured PCoA aneurysms.
      PCoA aneurysms of H/D > 1 and H/S <= 2 with surface area > 70 mm2, H/D <= 1 and
      H/S > 2 with neck diameter > 2.3 mm, H/D <= 1 and H/S <= 2 with aneurysmal
      height/parent diameter ratio > 1.0, and H/D > 1 and H/S > 2 with aneurysmal angle
      > 115 degrees  need special attention for clinical diagnosis and treatment. The
      study highlighted the importance of the two-step analysis method for clinical
      evaluation of PCoA aneurysm rupture.

PMID- 29843920
TI  - Direct characterization of cytoskeletal reorganization during blood platelet
      spreading.
AB  - Blood platelets are the key cellular players in blood clotting and thus of great
      biomedical importance. While spreading at the site of injury, they reorganize
      their cytoskeleton within minutes and assume a flat appearance. As platelets
      possess no nucleus, many standard methods for visualizing cytoskeletal components
      by means of fluorescence tags fail. Here we employ silicon-rhodamine actin and
      tubulin probes for imaging these important proteins in a time-resolved manner. We
      find two distinct timescales for platelet spread area development and for
      cytoskeletal reorganization, indicating that although cell spreading is most
      likely associated with actin polymerization at the cell edges, distinct, stress
      fiber-like actin structures within the cell, which may be involved in the
      generation of contractile forces, form on their own timescale. Following
      microtubule dynamics allows us to distinguish the role of myosin, microtubules
      and actin during early spreading.

PMID- 29843921
TI  - Transcriptional analysis of Myceliophthora thermophila on soluble starch and role
      of regulator AmyR on polysaccharide degradation.
AB  - Thermophilic fungus Myceliophthora thermophila has great capacity for biomass
      degradation and is an attractive option for use as cell factory to produce
      chemicals directly from renewable polysaccharides, such as starch, rather than
      monomer glucose. To date, there has been no transcriptomic analysis of this
      thermophilic fungus on starch. This study determined the transcriptomic profile
      of M. thermophila responding to soluble starch and a 342-gene set was identified
      as a "starch regulon", including the major amylolytic enzyme (Mycth_72393). Its
      overexpression led to increased amylase activities on starch by 35%. Furthermore,
      overexpressing the key amylolytic enzyme regulator AmyR in M. thermophila
      significantly increased amylase activity by 30%. Deletion of amyR by the
      CRISPR/Cas9 system led to the relief of carbon catabolite repression and 3-fold
      increased lignocellulase activities on cellulose. This study will accelerate
      rational fungal strain engineering for biochemical production from biomass
      substrates such as raw corn starch and even crop straw.

PMID- 29843922
TI  - Embryonal brain tumor with unknown primary lesion and massive cerebrospinal fluid
      dissemination: A case report.
AB  - The 2007 World Health Organization Classification of Tumors of the Central
      Nervous System (CNS) categorized embryonal tumors of the CNS into three classes:
      medulloblastoma, CNS primitive neuroectodermal tumor, and atypical
      teratoid/rhabdoid tumor. Due to the lack of specific histological features, it
      was sometimes difficult to accurately differentiate CNS embryonal tumors
      pathologically. Here, we report a case of a young man, who presented with
      headache. Gadolinium-enhanced magnetic resonance imaging demonstrated massive
      lesions in the cerebrospinal fluid space, which strongly suggested leptomeningeal
      dissemination of a brain tumor. The histology showed the tumor comprised densely
      packed, small cells with scant cytoplasm. Immunoreactivities were positive for
      synaptophysin and chromogranin A, and negative for glial fibrillary acidic
      protein, S-100, EMA, and CD20. Because the tumors were located in multiple sites
      and most of them were within the cerebrospinal fluid space, the primary lesion
      could not be determined. We diagnosed this case as 'CNS primitive neuroectodermal
      tumor' by the patient age and predominantly supratentorial distribution of the
      lesions. After the induction therapy, WHO published its updated classification in
      2016. Considering the possibility that the diagnosis is medulloblastoma, we
      performed additional immunohistochemical analyses, and diagnosed Group 3
      medulloblastoma because of the expression of natriuretic peptide receptor 3.

PMID- 29843924
TI  - Factors associated with antimuscarinic drug persistence and increasing drug
      persistence after switching to mirabegron for overactive bladder patients.
AB  - PURPOSE: To evaluate long-term antimuscarinic drug persistence and its associated
      characteristics in patients with overactive bladder (OAB) treated with
      antimuscarinic agents. We also assessed the efficacy and safety of switching from
      solifenacin to mirabegron in patients refractory to antimuscarinic therapy.
      METHODS: In this prospective, open-label, 48-month study, 416 patients (mean age,
      70.6 +/- 12.4 years) were enrolled. All patients completed the overactive bladder
      symptom score and urgency severity score questionnaires, along with initial and
      follow-up uroflowmetry. All patients received antimuscarinic solifenacin 5 mg
      daily. Mirabegron (25 mg daily) was suggested in patients that were refractory to
      antimuscarinic therapy or had intolerable side effects. RESULTS: The mean
      solifenacin persistence was 6.6 +/- 8.1 months (range, 0.5-48 months). Only 81
      (19.5%) patients had drug persistence of >=12 months. Male sex, age, cerebral
      vascular accident, maximum flow rate, and post-void residual were associated with
      solifenacin persistence in the univariate analysis. Age (odds ratio [OR], 0.14;
      95% CI, 0.08-0.21) was the only independent predictor in the multivariate
      logistic regression. Of the 416 patients, 171 (60.8%) changed from solifenacin to
      mirabegron for due to the persistence of OAB symptoms. The switch resulted in a
      significantly longer period of actual OAB pharmacotherapy (9.3 +/- 9.2 vs 13.3 +/
      9.3 months, p < 0.001). CONCLUSION: Long-term drug persistence of solifenacin
      was low during the 2-year follow-up. Age was an independent factor associated
      with longer drug persistence. Switching from solifenacin to mirabegron was an
      effective and safe alternative for OAB patients that were refractory to
      solifenacin treatment.

PMID- 29843923
TI  - Surface Area to Volume Ratio: A Natural Variable for Bacterial Morphogenesis.
AB  - An immediately observable feature of bacteria is that cell size and shape are
      remarkably constant and characteristic for a given species in a particular
      condition, but vary quantitatively with physiological parameters such as growth
      rate, indicating both genetic and environmental regulation. However, despite
      decades of research, the molecular mechanisms underlying bacterial morphogenesis
      have remained incompletely characterized. We recently demonstrated that a wide
      range of bacterial species exhibit a robust surface area to volume ratio (SA/V)
      homeostasis. Because cell size, shape, and SA/V are mathematically
      interconnected, if SA/V is indeed the natural variable that cells actively
      monitor, this finding has critical implications for our understanding of
      bacterial morphogenesis, placing fundamental constraints on the sizes and shapes
      that cells can adopt. In this Opinion article we discuss the broad implications
      that this novel perspective has for the field of bacterial growth and
      morphogenesis.

PMID- 29843925
TI  - Extranodal NK/T-cell lymphoma of the nasal cavity developed in a patient with
      intestinal Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder.
AB  - Extranodal NK/T cell lymphoma, nasal type (ENKL) developed in a patient with
      intestinal Epstein-Barr virus (EBV)-positive T/NK-cell lymphoproliferative
      disorder (LPD). The patient was a 46-year-old Chinese man who complained of
      diarrhea and abdominal pain without immune-deficiency. Endoscopy demonstrated
      ileum ulcers like Crohn's disease, without histological granulomas. His symptoms
      continued waxing and waning for 3 years until he developed overt lymphoma (ENKL)
      in the nasal cavity. The ileum lesions exacerbated into a large deep ulcer, and
      the biopsy specimens from the ileum, including the one 3 years ago, showed
      infiltration of small lymphocytes containing many EBV-positive T/NK cells without
      atypia. Thus, the patient illness of intestine was revealed as intestinal EBV
      positive T/NK-cell LPD, which might be closely associated with development of
      ENKL in this patient. In cases of inflammatory bowel disease without typical
      clinical courses and histological findings, check-up of EBV in the biopsy might
      help correct diagnosis.

PMID- 29843926
TI  - Lanthanum deposition corresponds to white lesions in the stomach.
AB  - OBJECTIVE: Although lanthanum deposition in the stomach has been most frequently
      reported to occur as white lesions, no study has investigated whether the white
      lesions observed during esophagogastroduodenoscopy are truly lanthanum-related.
      Here, we retrospectively investigated the amount of lanthanum in endoscopic
      biopsy specimens. METHODS: We reviewed four patients showing gastric white spots
      or annular whitish mucosa in the gastric white lesions (Bw) and peripheral mucosa
      where the white substance was not endoscopically observed (Bp) during biopsy. We
      also reviewed three patients with diffuse whitish mucosa and three patients with
      no whitish lesions. We performed scanning electron microscopy and energy
      dispersive X-ray spectrometry to quantify the lanthanum elements (wt%) in the
      biopsy specimens. RESULTS: The amount of lanthanum in the Bw ranged from 0.15
      0.31 wt%, whereas that of Bp was 0.00-0.13 wt%. The difference was statistically
      significant (P < 0.05). The amount of lanthanum in the Bw, endoscopically
      presented with white spots or annular whitish mucosa, was significantly higher
      than that of no whitish lesions (0.05-0.14 wt%, P < 0.05). The amount of
      lanthanum was also higher in the diffuse whitish mucosa (0.21-0.23 wt%) compared
      with no whitish lesions (P < 0.01). CONCLUSIONS: This study is the first to
      reveal that pathological lanthanum deposition corresponds to the endoscopically
      observed white lesions in the gastric mucosa. Therefore, during
      esophagogastroduodenoscopy, physicians should pay attention to possible presence
      of white lesions in patients treated with oral lanthanum carbonate to ensure
      prompt identification of associated issues.

PMID- 29843927
TI  - Hepatic endometrial stromal sarcoma.
AB  - Endometrial stromal sarcomas are rare tumors that may recur or metastasize many
      years after their initial presentation. Though most recurrences are within the
      pelvis, distant metastases can occur, and are most common to the lungs.
      Metastases to the liver are extremely rare. Herein we report two cases of
      endometrial stromal sarcoma with metastases to the liver without a prior history
      of endometriosis, accompanied by their histology, immunohistochemistry, and
      molecular analysis in the context of a relevant literature review.

PMID- 29843928
TI  - Polytrauma from Unintentional Pressure Cooker Explosion: A Case Report.
AB  - BACKGROUND: Pressure cookers are common kitchen appliances with a good safety
      record and only rare associated explosions. CASE REPORT: Here we present a case
      of unintentional pressure cooker explosion leading to polytrauma with injuries
      including pneumothorax, intracranial hemorrhage, open skull fracture, and
      multiple facial fractures. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?:
      Extreme forces and temperatures are involved in pressure cooking. Given the
      infrequent but real risk of mechanical failure and the increasing use of such
      devices to create intentional explosions, emergency physicians should be aware of
      the potentially significant blast injuries that can be associated with them.

PMID- 29843929
TI  - MicroRNA-4497 functions as a tumor suppressor in laryngeal squamous cell
      carcinoma via negatively modulation the GBX2.
AB  - OBJECTIVE: MicroRNAs (miRNAs) are aberrantly expressed in various tumors and play
      a critical role in the progression and development of tumors. However, there is
      little information about the role of miR-4497 in laryngeal squamous cell
      carcinoma (LSCC). The aim of this study is to investigate the role of miR-4497 in
      LSCC. METHODS: MiR-4497 expression in tumor tissues and adjacent normal tissues
      was measured by RT-PCR. The effects of miR-4497 on cell viability and apoptosis
      were evaluated by the MTT assay, Flow cytometry and caspase-3 activity assay.
      Western blot analysis was used to measure the expression of various proteins.
      Bioinformatic analysis and luciferase reporter assay were applied to investigate
      the relationship between miR-4497 and GBX2. RESULTS: We found that miR-4497
      expression was downregulated in LSCC tumor tissues and cell lines compared to the
      normal counterparts. Overexpression of miR-4497 inhibits the proliferation and
      induces apoptosis of LSCC cells accompanied by the down-regulation of anti
      apoptotic Bcl-2 proteins. Mechanisms investigation revealed that GBX2 is a direct
      target of miR-4497. miR-4497 expression was inversely correlated with GBX2
      expression in LSCC tissues. Moreover, overexpression of miR-4497 leads to the
      activation of ERK, JNK but not p38. Inhibition of ERK by specific inhibitor
      SCH772984 could interfere the apoptosis induced by overexpression of miR-4497.
      CONCLUSION: Therefore, our results indicate that miR-4497 may play a suppressive
      role in LSCC by targeting GBX2, which offer new insights into the tumorigenesis
      of LSCC.

PMID- 29843930
TI  - Cardiogenic shock in acute myocardial infarction: Stratify to prevent.

PMID- 29843931
TI  - Blepharoplasty in the works of Aulo Cornelio Celso.

PMID- 29843932
TI  - Transconjunctival suturing of the scleral flap in late hypotony maculopathy after
      non-penetrating deep sclerectomy.
AB  - CLINICAL CASE: A 63-year-old man presents with late hypotony maculopathy after
      non-penetrating deep sclerectomy. Hypotonia and visual acuity are improved after
      transconjunctival suturing of the scleral flap. DISCUSSION: Hypotony maculopathy
      may occur as a late complication after glaucoma surgery. Transconjunctival
      suturing of the scleral flap can be useful when conservative measures have
      failed.

PMID- 29843933
TI  - Patient perspectives on racial and ethnic implicit bias in clinical encounters:
      Implications for curriculum development.
AB  - OBJECTIVE: Patients describe feelings of bias and prejudice in clinical
      encounters; however, their perspectives on restoring the encounter once bias is
      perceived are not known. Implicit bias has emerged as a target for curricular
      interventions. In order to inform the design of novel patient-centered curricular
      interventions, this study explores patients' perceptions of bias, and suggestions
      for restoring relationships if bias is perceived. METHODS: The authors conducted
      bilingual focus groups with purposive sampling of self-identified Black and
      Latino community members in the US. Data were analyzed using grounded theory.
      RESULTS: Ten focus groups (in English (6) and Spanish (4)) with N = 74
      participants occurred. Data analysis revealed multiple influences patients'
      perception of bias in their physician encounters. The theory emerging from the
      analysis suggests if bias is perceived, the outcome of the encounter can still be
      positive. A positive or negative outcome depends on whether the physician
      acknowledges this perceived bias or not, and his or her subsequent actions.
      CONCLUSIONS: Participant lived experience and physician behaviors influence
      perceptions of bias, however clinical relationships can be restored following
      perceived bias. PRACTICE IMPLICATIONS: Providers might benefit from skill
      development in the recognition and acknowledgement of perceived bias in order to
      restore patient-provider relationships.

PMID- 29843934
TI  - An N of one.

PMID- 29843935
TI  - Associations of multiple unhealthy lifestyle behaviors with overweight/obesity
      and abdominal obesity among Brazilian adolescents: A country-wide survey.
AB  - BACKGROUND AND AIMS: Physical inactivity, unhealthy diet, smoking and heavy
      drinking are four key unhealthy lifestyle behaviors (ULB) that may influence body
      weight and obesity development. More recently, sedentary time has been recognized
      as another potentially emerging ULB related to obesity. We therefore investigated
      the association of multiple ULB with overweight/obesity and abdominal obesity
      among Brazilian adolescents. METHODS AND RESULTS: This cross-sectional study
      involved 62,063 students (12-17 years). Physical inactivity, high screen time,
      low fiber intake, binge drinking and smoking were self-reported and combined to a
      ULB risk score, ranging from zero to five. Participants were classified as
      overweight/obese or with abdominal obesity using sex and age-specific cut-off
      points for BMI and waist circumference, respectively. Poisson regression models
      were used to examine the associations between ULB with overweight/obesity and
      abdominal obesity, adjusted for socio-demographic variables. Overall, 2.3%,
      18.9%, 43.9%, 32.3% and 2.6% of participants reported zero, one, two, three and
      four/five ULB, respectively. Higher ULB risk score was associated with
      overweight/obesity and abdominal obesity in a dose-response gradient. Among 32
      possible combinations of ULB, the three most prevalent combinations (physical
      inactivity + low fiber intake; high screen time + low fiber intake; physical
      inactivity + high screen time + low fiber intake) were positively associated with
      general and abdominal obesity. CONCLUSIONS: Our findings suggest a synergistic
      relationship between ULB and general and abdominal obesity. Preventive efforts
      targeting combined ULB should be sought to reduce the prevalence of general and
      abdominal obesity in Brazilian youth.

PMID- 29843936
TI  - Corrigendum to "How does questioning influence nursing students' clinical
      reasoning in problem-based learning? A scoping review" [Nurse Educ. Today 65
      (2018) 108-115].

PMID- 29843937
TI  - Prognostic significance of circumferential resection margin involvement in
      patients receiving potentially curative treatment for oesophageal cancer.
AB  - INTRODUCTION: The utility of Circumferential Resection Margin (CRM) status in
      predicting prognosis in oesophageal cancer is controversial, with different
      definitions used by the College of American Pathologists and the Royal College of
      Pathologists. We aimed to determine prognostic significance of CRM involvement
      and evaluate which system is the best predictor of prognosis. METHODS: A cohort
      of 390 patients who had potentially curative oesophagectomy (- + neoadjuvant
      chemotherapy) were analysed. Associations between CRM involvement and patient
      outcome were assessed for the whole cohort, and for pre-specified subgroups of T3
      tumours and those who received neo-adjuvant chemotherapy. RESULTS: CRM
      involvement was associated with higher T and N stage, tumour differentiation,
      increased tumour length and both lymphovascular and perineural invasion. Overall
      Survival (OS) and Recurrence Free Survival (RFS) significantly worsened with CRM
      involvement (p = 0.001, p < 0.001). R1a (<1 mm but no macroscopic involvement)
      resulted in significantly improved OS (p = 0.037) and RFS (P = 0.026) compared to
      R1b (macroscopic involvement), but did not differ significantly from R0 (>=1 mm).
      The association between CRM-involvement and both OS and RFS remained significant
      regardless of whether neoadjuvant chemotherapy was given. However, CRM
      involvement was not a significant prognostic marker in T3 patients (p = 0.148).
      Multivariable analysis found N stage, lymphovascular invasion, patient age and
      neoadjuvant chemotherapy to be significantly predictive of patient outcome. CRM
      involvement was not a significant independent prognostic marker. CONCLUSIONS: CRM
      involvement was not found to be independently predictive of prognosis, after
      accounting for other prognostic markers. As such, CRM should not be considered a
      major prognostic factor in patients with oesophageal cancer.

PMID- 29843938
TI  - Reply to: Dissecting the therapeutic implications of the complex SMAD4 regulatory
      network in metastatic colorectal cancer.

PMID- 29843939
TI  - Identification of algal growth inhibitors in treated waste water using effect
      directed analysis based on non-target screening techniques.
AB  - Growth inhibition of freshwater microalga Pseudokirchneriella subcapitata caused
      by a waste water treatment plant (WWTP) effluent extract was investigated using
      an effect directed analysis (EDA) approach. The objective was to identify
      compounds responsible for the toxicity by combining state-of-the-art sampling,
      bioanalytical, fractionation and non-target screening techniques. Three
      fractionation steps of the whole extract were performed and bioactive fractions
      were analysed with GC (xGC)-MS and LC-HRMS. In total, 383 compounds were
      tentatively identified, and their toxicity was characterized using US EPA Ecotox
      database, open scientific literature or modelled by ECOSAR. Among the top-ranking
      drivers of toxicity were pesticides and their transformation products,
      pharmaceuticals (barbiturate derivatives and macrolide antibiotics e.g.
      azithromycin), industrial compounds or caffeine and its metabolites. Several of
      the top-ranking pesticides are no longer registered for use in plant protection
      products or biocides in the Czech Republic (e.g. prometryn, atrazine, acetochlor,
      resmethrin) and some are approved only for use in biocides (e.g. terbutryn,
      carbendazim, phenothrin), which indicates that their non-agricultural input into
      aquatic environment via WWTPs should be carefully considered. The study
      demonstrated a functional strategy of combining biotesting, fractionation and non
      target screening techniques in the EDA study focused on the identification of
      algal growth inhibitors in WWTP effluent.

PMID- 29843940
TI  - Thiamine for preventing dementia development among patients with alcohol use
      disorder: A nationwide population-based cohort study.
AB  - OBJECTIVE OF STUDY: Alcohol use disorder is one of the most important factors
      contributing to dementia. This study examined the protective effect of thiamine
      administration on the incidence of dementia among patients with alcohol use
      disorder in Taiwan by evaluating a nationwide database. METHODS: We retrieved
      data for this retrospective cohort study from the Longitudinal Health Insurance
      Database 1995-2000. Patients receiving thiamine therapy after the diagnosis of
      alcohol use disorder were recruited as the thiamine therapy (TT) group, and the
      comparison group without TT (NTT group) included randomly assigned and age-, sex
      , and index year-matched individuals with alcohol use disorder. Demographic data,
      comorbid medical disorders, and psychotropic medication use were evaluated and
      controlled. The cumulative defined daily dose (DDD) was analyzed to demonstrate
      the dose effect. RESULTS: Each group had 5059 patients. The TT group had a lower
      crude hazard ratio (0.76; 95% confidence interval: 0.60-0.96) of dementia than
      the NTT group. After adjusting for demographic data, comorbidity, and
      psychotropic medication use, the adjusted hazard ratio was 0.54 (95% confidence
      interval: 0.43-0.69). The significance existed among TT subjects with cumulative
      DDD higher than 23. The Kaplan-Meier analysis demonstrated a lower cumulative
      incidence of dementia in the TT group than in the NTT group. CONCLUSION: The
      results indicated that thiamine therapy could be a protective factor for dementia
      development in patients with alcohol use disorder. Thiamine therapy should be a
      crucial part of the treatment plan and health policies to prevent dementia
      development or progression among patients with alcohol use disorder.

PMID- 29843941
TI  - Glyphosate affects swine ovarian and adipose stromal cell functions.
AB  - Although Glyphosate (GLY) is a widely used pesticide, its effects on ovarian
      function and stem cell differentiation are still largely unknown. Therefore, as a
      contribution on this subject, the present work reports an investigation of the in
      vitro effects of GLY on swine granulosa cells and adipose stromal cells (ASCs).
      The effect of GLY at different doses (0.2, 4 and 16 MUg/mL) was evaluated on
      granulosa cells growth (BrDU incorporation and ATP production), steroidogenesis
      (17-beta estradiol and progesterone secretion) and redox status (superoxide and
      nitric oxide production and non-enzymatic scavenging activity). GLY has been
      shown to inhibit cell growth, 17-beta estradiol and non-enzymatic scavenging
      activity and to increase progesterone and nitric oxide secretion (P < 0.05). In
      addition, GLY significantly decreased the viability of ASCs (P < 0.001), and
      inhibited their adipogenic differentiation. These data indicate that GLY alters
      the main features of granulosa cells and ASCS thus suggesting that GLY could
      affect both reproductive function and adipose tissues homeostasis.

PMID- 29843942
TI  - Involvement of lipopolysaccharide in ovarian cystic follicles in dairy cow:
      Expressions of LPS receptors and steroidogenesis-related genes in follicular
      cells of cystic follicles.
AB  - In ovarian cystic follicles, molecular changes in the growing follicle may have a
      local action and contribute to anovulation and cystic formation. One of the
      candidate molecules that affect the steroid and gonadotropin signaling systems of
      cystic follicles is lipopolysaccharide (LPS), a cell wall component of gram
      negative bacteria. To examine the molecular characteristics of bovine cystic
      follicles, we analyzed LPS concentration in follicular fluid of cystic follicles,
      and the expression of LPS receptors and steroidogenesis-related genes in
      granulosa and theca cells. Cystic follicles were categorized as estradiol (E2)
      active (EACF) and E2-inactive cystic follicle (EICF). Overall, LPS concentration
      in follicular fluid of EACF and EICF was higher compared with healthy
      preovulatory follicles (POF). Expression of luteinizing hormone receptor (LHR) in
      granulosa and thecal cells was decreased in EACF and EICF compared with POF.
      Expression of CYP19 in granulosa cells of EACF and EICF was lower than POF. High
      expression of StAR in granulosa and thecal cells was observed in EICF. In
      granulosa cells, the expression of TLR4 and TLR2 mRNA was higher in EICF than
      other follicles. By contrast, higher expression of TLR2 in thecal cells was
      observed in EICF. Thus, high LPS concentration in follicular fluid of cystic
      follicles may be associated with the regulation of expression of steroidogenesis
      related genes in granulosa and theca cells. These finding revealed the molecular
      characteristics of bovine ovarian cysts and possible involvement of LPS in the
      pathology of cystic follicle diseases.

PMID- 29843943
TI  - Designing flexible low-viscous sieving media for capillary electrophoresis
      analysis of ribonucleic acids.
AB  - Modified messenger RNA (mRNA) has recently become a new prospective class of drug
      product. Consequently, stability indicating separation methods are needed to
      progress pharmaceutical development of mRNA. A promising separation technique for
      the analysis of mRNA is capillary gel electrophoresis (CGE). We designed a
      flexible, low-viscous sieving medium for CGE, based on high mass linear
      polyvinylpyrrolidone (PVP) and glycerol. A Central Composite Face-centered design
      resulted in a strong model that allowed us to predict suitable sieving media
      compositions by using multi-objective optimization. The way of working proposed
      in this paper gives analysts the freedom to design a suitable sieving medium for
      their response(s) of interest, for purity and stability analysis of
      polynucleotides with a size around 100-1000 bases. Depending on the criteria for
      the analysis there will be a trade-off between different suitable conditions. By
      using this method, we created a sieving medium that was able to improve
      resolution, peak height and analysis time of an RNA ladder compared to the
      current commercially available separation gels.

PMID- 29843944
TI  - Theoretical and experimental investigation of the focusing position in
      asymmetrical flow field-flow fractionation (AF4).
AB  - To better understand the focusing process and to determine the focusing position
      (zfoc) in Asymmetrical Flow Field-Flow Fractionation (AF4), theoretical and
      experimental studies were performed. A new theoretical expression that allows the
      calculation of zfoc in AF4 channels of any shape having an axial plane of
      symmetry was established. The equation was then applied to the particular case of
      a trapezoidal AF4 channel with tapered ends. The applicability of this equation
      was verified by comparing the calculated results with the experimental measures
      of the focusing position obtained using blue dextran dye under different flow
      conditions. The calculated values and the experimental results were in good
      agreement. The total uncertainty associated with the calculated zfoc was
      evaluated and was lower than 10%. A good repeatability and reproducibility of the
      focusing position was obtained. Moreover, the effects of the sample-injection
      position, the spacer thickness, the membrane aging, and the nature of the
      injected sample on the focusing position were investigated: zfoc was not
      influenced by these parameters, proving the universal applicability of the
      equation given in this work for predicting the focusing position, when the
      assumption of constancy of the cross-flow velocity at the membrane, which
      underlies this equation, is fulfilled. Additionally, it is notable that this
      theoretical expression is suitable for different models of AF4 channel and not
      peculiar to specific suppliers.

PMID- 29843945
TI  - Isolation of biofunctional bovine immunoglobulin G from milk- and colostral whey
      with mixed-mode chromatography at lab and pilot scale.
AB  - The aim of the present work was to develop a new scalable and cost-efficient
      process to isolate bovine immunoglobulin G from colostral whey with high purity
      and minimal loss of activity. The mixed mode material Mercapto-Ethyl-Pyridine
      HypercelTM was identified appropriate for direct capture of immunoglobulin G. The
      binding mechanism is primarily based on hydrophobic interactions at physiological
      conditions. As compared to immunoglobulin G, all other low molecular whey
      proteins such as alpha-Lactalbumin or beta-Lactoglobulin, except lactoperoxidase,
      are more hydrophilic and were therefore found in the flow-through fraction. In
      order to remove lactoperoxidase as an impurity the column was combined in series
      with a second mixed mode material (CaptoTM- with N-benzoyl-homocysteine as
      ligand) using the same binding conditions. At pH 7.5 the carboxyl group of this
      ligand is negatively charged and can hence bind the positively charged
      lactoperoxidase, whose isoelectric point is at pH 9.6. After sample application,
      the columns were eluted separately. By combining the two columns it was possible
      to obtain immunoglobulin G with a purity of >96.1% and yield of 65-80%. The
      process development was carried out using 1 mL columns and upscaling was
      performed in three steps up to a column volume of 8800 mL for the HypercelTM
      column and 3000 mL for the CaptoTM- column. At this scale it is possible to
      obtain 130-150 g pure immunoglobulin G from 3 L colostrum within five hours,
      including the regeneration of both columns. Additionally, the impact of freeze
      drying on the isolated immunoglobulin G was studied. The nativity of the freeze
      dried immunoglobulin was above 95%, which was proven by reversed phase liquid
      chromatography and validated by differential scanning calorimetry. The activity
      of immunoglobulin G was preserved over the isolation process and during drying as
      measured by enzyme-linked immunosorbent assay. In conclusion, by applying the
      proposed isolation process, it becomes feasible to obtain pure, active and stable
      imunnunoglobulin G at large scale.

PMID- 29843946
TI  - Design keys for paper-based concentration gradient generators.
AB  - The generation of concentration gradients is an essential operation for several
      analytical processes implemented on microfluidic paper-based analytical devices.
      The dynamic gradient formation is based on the transverse dispersion of chemical
      species across co-flowing streams. In paper channels, this transverse flux of
      molecules is dominated by mechanical dispersion, which is substantially different
      than molecular diffusion, which is the mechanism acting in conventional
      microchannels. Therefore, the design of gradient generators on paper requires
      strategies different from those used in traditional microfluidics. This work
      considers the foundations of transverse dispersion in porous substrates to
      investigate the optimal design of microfluidic paper-based concentration gradient
      generators (MUPGGs) by computer simulations. A set of novel and versatile MUPGGs
      were designed in the format of numerical prototypes, and virtual experiments were
      run to explore the ranges of operation and the overall performance of such
      devices. Then physical prototypes were fabricated and experimentally tested in
      our lab. Finally, some basic rules for the design of optimized MUPGGs are
      proposed. Apart from improving the efficiency of mixers, diluters and MUPGGs, the
      results of this investigation are relevant to attain highly controlled
      concentration fields on paper-based devices.

PMID- 29843947
TI  - Intracochlear pressure measurements during acoustic shock wave exposure.
AB  - INTRODUCTION: Injuries to the peripheral auditory system are among the most
      common results of high intensity impulsive acoustic exposure. Prior studies of
      high intensity sound transmission by the ossicular chain have relied upon
      measurements in animal models, measurements at more moderate sound levels (i.e. <
      130 dB SPL), and/or measured responses to steady-state noise. Here, we directly
      measure intracochlear pressure in human cadaveric temporal bones, with fiber
      optic pressure sensors placed in scala vestibuli (SV) and tympani (ST), during
      exposure to shock waves with peak positive pressures between ~7 and 83 kPa.
      METHODS: Eight full-cephalic human cadaver heads were exposed, face-on, to
      acoustic shock waves in a 45 cm diameter shock tube. Specimens were exposed to
      impulses with nominal peak overpressures of 7, 28, 55, & 83 kPa (171, 183, 189, &
      192 dB pSPL), measured in the free field adjacent to the forehead. Specimens were
      prepared bilaterally by mastoidectomy and extended facial recess to expose the
      ossicular chain. Ear canal (EAC), middle ear, and intracochlear sound pressure
      levels were measured with fiber-optic pressure sensors. Surface-mounted sensors
      measured SPL and skull strain near the opening of each EAC and at the forehead.
      RESULTS: Measurements on the forehead showed incident peak pressures
      approximately twice that measured by adjacent free-field and EAC entrance
      sensors, as expected based on the sensor orientation (normal vs tangential to the
      shock wave propagation). At 7 kPa, EAC pressure showed gain, calculated from the
      frequency spectra, consistent with the ear canal resonance, and gain in the
      intracochlear pressures (normalized to the EAC pressure) were consistent with
      (though somewhat lower than) previously reported middle ear transfer functions.
      Responses to higher intensity impulses tended to show lower intracochlear gain
      relative to EAC, suggesting sound transmission efficiency along the ossicular
      chain is reduced at high intensities. Tympanic membrane (TM) rupture was observed
      following nearly every exposure 55 kPa or higher. CONCLUSIONS: Intracochlear
      pressures reveal lower middle-ear transfer function magnitudes (i.e. reduced gain
      relative to the ear canal) for high sound pressure levels, thus revealing lower
      than expected cochlear exposure based on extrapolation from cochlear pressures
      measured at more moderate sound levels. These results are consistent with lowered
      transmissivity of the ossicular chain at high intensities, and are consistent
      with our prior report measuring middle ear transfer functions in human cadaveric
      temporal bones with high intensity tone pips.

PMID- 29843948
TI  - Sandwich osteotomy for the reconstruction of deficient alveolar bone.
AB  - Alveolar bone deficiency is a very common problem encountered by the practitioner
      when planning dental implants. The severity of the deficiency is variable. Many
      practitioners perform augmentation using the method they feel comfortable with
      and do not necessarily use the most appropriate method. This is a retrospective
      study on 21 patients between the ages of 25 and 63 years exhibiting moderate
      vertical alveolar bone deficiency and treated by the sandwich technique. Mean
      vertical bone gain was 7.5mm. Sixty-one dental implants were inserted showing a
      survival rate of 96.7% with a median of 3.1 years follow-up. Main advantages of
      the method include minimal relapse, single operation and preservation of the
      native cortical bone in the occlusal surface. We believe the surgeon should
      maintain the capability of using different augmentation techniques and utilize
      them appropriately for different severities of deficiency. We wish to establish a
      paradigm for using different augmentation methods We recommend using the sandwich
      technique in the moderate deficient cases as described in this work, using
      alveolar distraction osteogenesis for the severe cases as described in our
      previous work, where lack of soft tissue for proper closure is a major
      limitation, and using guided bone regeneration for minor deficiencies.

PMID- 29843949
TI  - Comparison of osseous healing after sagittal split ramus osteotomy and intraoral
      vertical ramus osteotomy.
AB  - The sagittal split ramus osteotomy (SSRO) is generally associated with greater
      postoperative stability than the intraoral vertical ramus osteotomy (IVRO);
      however, it entails a risk of inferior alveolar nerve damage. In contrast, IVRO
      has the disadvantages of slow postoperative osseous healing and projection of the
      antegonial notch, but inferior alveolar nerve damage is believed to be less
      likely. The purposes of this study were to compare the osseous healing processes
      associated with SSRO and IVRO and to investigate changes in mandibular width
      after IVRO in 29 patients undergoing mandibular setback. On computed tomography
      images, osseous healing was similar in patients undergoing SSRO and IVRO at 1year
      after surgery. Projection of the antegonial notch occurred after IVRO, but
      returned to the preoperative state within 1year. The results of the study
      indicate that IVRO is equivalent to SSRO with regard to both bone healing and
      morphological recovery of the mandible.

PMID- 29843950
TI  - Short implants versus bone augmentation in combination with standard-length
      implants in posterior atrophic partially edentulous mandibles: systematic review
      and meta-analysis with the Bayesian approach.
AB  - The use of short implants as an alternative to bone reconstruction techniques for
      the placement of standard-length dental implants is a debated topic. The aim of
      this study was to perform a systematic review and meta-analysis in order to
      assist in the clinical decision making about the most appropriate approach for
      the fixed rehabilitation of the posterior atrophic partially edentulous lower
      jaws. Only randomized trials with at least 1-year follow-up were included. Of the
      1024 studies initially retrieved, 14 articles were selected and independently
      evaluated by two reviewers. Finally, four studies were included, and underwent
      data extraction and meta-analysis with the Bayesian approach. Both treatment
      approaches provide high implant survival rate after 1year of function. However,
      the probability of survival rate of short implants being greater than standard
      length implants is 84%, and the probability of complications using short implants
      being greater than standard-length implants is 15.7%. In spite of similar
      survival rates when the residual bone is sufficient for placement of short
      implants, the latter should be preferred to augmentation techniques and standard
      length implants due to fewer complications, lower morbidity and greater comfort
      for patients.

PMID- 29843951
TI  - Man as a living bioreactor: Long-term histological aspects of a mandibular
      replacement engineered in the patient's own body.
AB  - In 2016, we reported the world's first reconstruction of a mandibular
      discontinuity defect using a custom-made bone transplant that had been
      prefabricated in the gastrocolic omentum using tissue engineering strategies.
      However, the tissue of an engineered human neomandible has not been evaluated
      histologically until now. The current study assessed the long-term histological
      characteristics of biopsies of the neomandible 9months after transplantation.
      Histological analysis showed an increased amount of vital mineralized bone tissue
      after 10months, in comparison to biopsies obtained earlier. The engineered bone
      covered the surface of the bone substitute material but also grew out typical
      structures of cancellous bone tissue without a core of BioOss. The amount of
      induced bone tissue was 32% in the biopsy. In addition, the soft tissue showed an
      alignment of the connective tissue fibres parallel to the trabecular bone.
      Increasing time and mechanical forces at the mandible led to an increased amount
      of mineralized tissue and remodelling of the connective tissue fibres after
      transplantation. Further research should focus on developing advanced scaffold
      materials, as the outer titanium mesh cage leads to complications.

PMID- 29843952
TI  - Jugular foramen tumour resulting in hypoglossal denervation pseudohypertrophy: a
      rare and significant cause for tongue asymmetry.
AB  - Paragangliomas of the jugular foramen are rare. They may present with symptoms of
      compression of the glossopharyngeal or vagus nerves, or due to secretion of
      catecholamines from chromaffin cells within the tumour. This case describes a
      rare presentation of glomus tumour. A 67-year-old patient presented with a 2
      month history of right-sided tongue swelling. She was found to have an obvious
      swelling on the right side of the tongue but no obvious weakness or fasciculation
      on initial examination. Ultrasound confirmed diffuse muscle swelling, but no
      lesion within the tongue. Magnetic resonance imaging of the neck revealed an
      ipsilateral glomus jugulare tumour that extended to the hypoglossal canal, and
      had resulted in ipsilateral denervation pseudohypertrophy of the lingual muscles.
      This paper reviews presentation of glomus jugulare tumours and contributes a
      novel presentation of a rare entity.

PMID- 29843953
TI  - Clinicopathological and prognostic significance of preoperative serum epidermal
      growth factor levels in patients with oral squamous cell carcinoma.
AB  - Epidermal growth factor (EGF) promotes tumourigenesis and tissue repair of
      epithelial and mesenchymal cells and has a role in chemotaxis, mitogenesis, cell
      motility, and cytoprotection. It also enhances the growth of cancers. EGF may
      therefore have a role in the initiation or promotion of oral carcinogenesis. The
      cases of 152 patients with oral squamous cell carcinoma whose preoperative serum
      EGF level was determined by enzyme-linked immunosorbent assay were analyzed
      retrospectively, along with those of 40 age- and sex-matched controls. Patients
      with higher levels of EGF were more likely to have neck lymph node metastasis
      (P=0.026), advanced stage cancer (P=0.04), and a worse survival status
      (P=0.0019). Multivariate analysis using the Cox proportional hazards model
      indicated that the EGF level was an independent predictor of poor survival
      (hazard ratio 1.99, P=0.018). Patients with higher preoperative serum EGF levels
      had significantly poorer cancer-specific survival by Kaplan-Meier analysis
      (P=0.032). This study indicates that a higher preoperative serum EGF level is
      associated with neck lymph node metastasis, more advanced stage, and poor
      survival. EGF should be considered as a potential prognostic biomarker and a
      therapeutic target for patients with oral cancer.

PMID- 29843954
TI  - Practice variation on use of antibiotics: An international survey among pediatric
      urologists.
AB  - INTRODUCTION AND BACKGROUND: Although there is abundance in literature focusing
      on the use of prophylactic antibiotics for adult urological procedures, the
      evidence for using antibiotics following common pediatric urological procedures
      is limited with no specific guidelines for use. Consequently, current practices
      on antibiotic usage for common interventions may be variable among practicing
      pediatric urologists, lacking evidence-based support. OBJECTIVE: The aim was to
      evaluate the current practice pattern on antibiotic usage for common
      interventions amongst pediatric urologists (PU) practicing in four English
      speaking sectors of the world. MATERIALS AND METHODS: An anonymous survey of five
      scenarios with multiple choice options was disseminated to all active practicing
      members of the Pediatric Urologist of Canada (PUC) and Society of Pediatric
      Urology of Australia and New Zealand (SPUNZA), as well as all those attending the
      2016 British Association of Pediatric Urology (BAPU) and 2017 American
      Association of Pediatric Urology (AAPU) meetings. The response for each scenario
      was summarized for overall practice pattern variation and the pattern for each
      sector was compared using the Fisher exact test. RESULTS: A total of 126
      respondents completed the survey (68.5% response rate) with at least a 65%
      response rate for each of the four sectors. The majority of respondents do not
      use antibiotics for indwelling urethral (46.8%) and suprapubic catheters (53.4%);
      however, they do give antibiotics for J-J stent placement (65.1%) and hypospadias
      surgery (84.9%), and use antibiotics after hypospadias surgery where catheters or
      stents are left indwelling (80.9%, 84.2%, respectively). Among those surveyed,
      the PUC members and AAPU PU demonstrated similar practice patterns which often
      significantly differed from that of SPUNZA members and BAPU attendees.
      Specifically, a significantly larger proportion of the North American pediatric
      urologists do not use antibiotics for common procedures compared with Australia,
      New Zealand, and the UK (Table). DISCUSSION: In the absence of prospective
      studies in antibiotic use for pediatric patients to guide clinicians, there is a
      clear variability among sectors in the use of antibiotics for most clinical
      scenarios investigated. With increasing resistance patterns and possible adverse
      effects of antibiotics, it is important that the international pediatric urology
      community engage in discussions and collaborations to address this issue.
      CONCLUSION: Practice patterns in antibiotic usage amongst PU varies widely, some
      of which may be associated with their local "culture." There is a need to
      understand these differences and begin to standardize treatment in the hopes of
      increasing appropriate use of antibiotics internationally.

PMID- 29843955
TI  - MicroRNA-148b Targets the TGF-beta Pathway to Regulate Angiogenesis and
      Endothelial-to-Mesenchymal Transition during Skin Wound Healing.
AB  - Transforming growth factor beta (TGF-beta) is crucial for regulation of the
      endothelial cell (EC) homeostasis. Perturbation of TGF-beta signaling leads to
      pathological conditions in the vasculature, causing cardiovascular disease and
      fibrotic disorders. The TGF-beta pathway is critical in endothelial-to
      mesenchymal transition (EndMT), but a gap remains in our understanding of the
      regulation of TGF-beta and related signaling in the endothelium. This study
      applied a gain- and loss-of function approach and an in vivo model of skin wound
      healing to demonstrate that miR-148b regulates TGF-beta signaling and has a key
      role in EndMT, targeting TGFB2 and SMAD2. Overexpression of miR-148b increased EC
      migration, proliferation, and angiogenesis, whereas its inhibition promoted
      EndMT. Cytokine challenge decreased miR-148b levels in ECs while promoting EndMT
      through the regulation of SMAD2. Finally, in a mouse model of skin wound healing,
      delivery of miR-148b mimics promoted wound vascularization and accelerated
      closure. In contrast, inhibition of miR-148b enhanced EndMT in wounds, resulting
      in impaired wound closure that was reversed by SMAD2 silencing. Together, these
      results demonstrate for the first time that miR-148b is a key factor controlling
      EndMT and vascularization. This opens new avenues for therapeutic application of
      miR-148b in vascular and tissue repair.

PMID- 29843956
TI  - Differential but Complementary HIF1alpha and HIF2alpha Transcriptional
      Regulation.
AB  - Effective vascular regeneration could provide therapeutic benefit for multiple
      pathologies, especially in chronic peripheral artery disease (PAD) and myocardial
      ischemia. The hypoxia inducible factors (HIFs) mediate the cellular
      transcriptional response to hypoxia and regulate multiple processes that are
      required for angiogenesis to ultimately restore perfusion and oxygen supply. In
      endothelial cells, both HIF1alpha and HIF2alpha are known to contribute to this
      role; however, the extent and individual roles of each of these HIFalpha remain
      unclear. To characterize the individual roles of HIFalpha, we sequenced the
      transcriptional outputs of stabilized forms of HIF1alpha and HIF2alpha, where
      they regulated 701 and 1,454 genes, respectively. HIF1alpha transcription
      primarily regulated metabolic reprogramming, whereas HIF2alpha exerted a larger
      role in regulating angiogenic extracellular signaling, guidance cues, and
      extracellular matrix remodeling factors. Furthermore, HIF2alpha almost
      exclusively regulated a large and diverse subset of transcription factors and
      coregulators that contribute to its diverse roles in hypoxia. Further
      understanding of how HIFs regulate cellular processes in hypoxia and angiogenesis
      could offer new avenues to modulate physiological angiogenesis to enhance
      revascularisation in ischemic conditions and other pathologies.

PMID- 29843957
TI  - Modelling of enterobacterial loads to the Baie des Veys (Normandy, France).
AB  - The Baie des Veys (Normandy, France) has abundant stocks of shellfish (oyster and
      cockle farms). Water quality in the bay is affected by pollutant inputs from a
      3500 km2 watershed and notably occasional episodes of contamination by faecal
      coliforms. In order to characterise enterobacterial loads and develop a plan of
      action to improve the quality of seawater and shellfish in the bay, a two-stage
      modelling procedure was adopted. This focused on Escherichia coli and included a
      catchment model describing the E. coli releases, and the transport and die-off of
      this bacteria up to the coast. The output from this model then served as input
      for a marine model used to determine the concentration of E. coli in seawater. A
      total 60 scenarios were tested, including different wind, tidal, rainfall and
      temperature conditions and accidental pollution events, for both current
      situations and future scenarios. The modelling results highlighted the impact of
      rainfall on E. coli loadings to the sea, as well as the effects of sluice gates
      and tidal cycles, which dictated the use of an hourly timescale for the modelling
      process. The coupled models also made it possible to identify the origin of these
      enterobacteria as found in shellfish harvesting areas, both in terms of the
      contributing watercourses and the sources of contamination of those watercourses.
      The tool can accordingly be used to optimise remedial action.

PMID- 29843958
TI  - Survival outcome of tonsillar squamous cell carcinoma (TSCC) in the context of
      human papillomavirus (HPV): A systematic review and meta-analysis.
AB  - OBJECTIVE: The objective of our study was to assess whether HPV-positive TSCC had
      better survival and prognosis rates, when compared to HPV-negative TSCC. METHOD:
      A systematic review and meta-analysis was performed comparing HPV status in TSCC
      patients. TSCC was confirmed with histopathology and HPV status was confirmed
      with PCR, immunohistochemistry and/or in-situ-hybridisation. The primary
      endpoints were overall survival (OS) and disease free survival (DFS). RESULTS:
      Twenty-four studies were identified, involving 1921 TSCC cases, of which 56.2%
      (1079) were HPV positive. OS was significantly higher in patients with HPV
      positive compared to HPV-negative TSCC in years 1-5 (OR 2.54, P < 0.01; OR 2.93 P
      < 0.01; OR 2.74 P < 0.01; OR 2.20 P < 0.01, and OR 2.14 P < 0.01 respectively).
      Similarly, DFS was also significantly higher in patients with HPV-positive
      compared to HPV-negative TSCC in years 1-3 (OR 2.86, P < 0.01; OR 2.60 P < 0.02;
      and OR 2.60 P < 0.01 respectively), which was attenuated in years 4 and 5 (OR
      1.83, P = 0.10 and OR 1.50, P = 0.12). CONCLUSION: This is the largest meta
      analysis with 1921 patients, comparing non-HPV induced TSCC and HPV induced TSCC,
      looking at outcome and survival. HPV-positive had better OS and DFS.

PMID- 29843959
TI  - Liver-Microbiome Axis in Health and Disease.
AB  - The intestinal and hepatobiliary tract exhibits host-specific commensal
      colonization. The resident microbiota has emerged as a key player in intestinal
      and hepatic diseases. Alcoholic and nonalcoholic fatty liver diseases
      (ALD/NAFLD), primary sclerosing cholangitis (PSC), liver cirrhosis, and some of
      their clinical complications, such as hepatic encephalopathy (HE), have been
      linked to a microbial signature, as also observed for severe liver inflammation
      in alcoholic hepatitis. In turn, the liver impacts, and communicates with, the
      microbiota through hepatic mediators, such as bile acids or inflammatory signals.
      Therefore, a liver-microbiome bidirectional crosstalk appears to be critical in
      health and various liver diseases and could be therapeutically targeted, such as
      by fecal microbiota transplantation.

PMID- 29843960
TI  - Injury risk-workload associations in NCAA American college football.
AB  - OBJECTIVES: To determine injury risk-workload associations in collegiate American
      Football. DESIGN: Retrospective analysis. METHODS: Workload and injury data was
      recorded from 52 players during a full NCAA football season. Acute, chronic, and
      a range of acute:chronic workload ratios (ACWR: 7:14, 7:21 and 7:28 day)
      calculated using rolling and exponentially weighted moving averages (EWMA) were
      plotted against non-contact injuries (regardless of time lost or not) sustained
      within 3- and 7-days. Injury risks were also determined relative to position and
      experience. RESULTS: 105 non-contact injuries (18 game- and 87 training-related)
      were observed with almost 40% sustained during the pre-season. 7-21 day EWMA
      ACWR's with a 3-day injury lag were most closely associated with injury
      (R2=0.54). Relative injury risks were >3* greater with high compared to moderate
      and low ratios and magnified when combined with low 21-day chronic workloads
      (injury probability=92.1%). Injury risks were similar across positions. 'Juniors'
      presented likely and possibly increased overall injury risk compared to
      'Freshman' (RR: 1.94, CI 1.07-3.52) and 'Seniors' (RR: 1.7, CI 0.92-3.14), yet no
      specific ACWR - experience or - position interactions were identified.
      CONCLUSIONS: High injury rates during college football pre-season training may be
      associated with high acute loads. In-season injury risks were greatest with high
      ACWR and evident even when including (more common and less serious) non-time loss
      injuries. Substantially increased injury risks when low 21-day chronic workloads
      and concurrently high EWMA ACWR highlights the importance of load management for
      individuals with chronic game- (non-involved on game day) and or training
      (following injury) absences.

PMID- 29843961
TI  - Vasovagal syncope-role of closed loop stimulation pacing.
AB  - The benefit of conventional pacing in vasovagal syncope remains controversial and
      is currently recommended for patients with recurrent syncope and documented
      asystole. In the last two decades, a growing body of evidence has emerged
      supporting the use of a new sensing technique called closed loop stimulation or
      CLS, to treat refractory vasovagal syncope. CLS uses a sensing algorithm that can
      detect variation in cardiac contractility and respond to drop in blood pressure
      by increasing the heart rate. Multiple observational and randomized studies have
      assessed its efficacy and showed its superiority to conventional pacing in
      reducing the burden of syncopal attacks in patients with cardio-inhibitory
      vasovagal syncope.

PMID- 29843962
TI  - Serological inflammatory factors as biomarkers for anatomic response in diabetic
      macular edema treated with anti-VEGF.
AB  - PURPOSE: To study the relationship between systemic pro-inflammatory factors and
      macular structural response to intravitreal bevacizumab for diabetic macular
      edema (DME). METHODS: Prospective study including 30 cases with DME, treated with
      bevacizumab and a minimum follow-up of 6 months. All cases underwent baseline
      laboratory testing for cardiovascular risk (high sensitivity C-reactive protein
      (hsCRP), homocystein), dyslipidemia, renal dysfunction and glucose control. Serum
      levels of VEGF, soluble ICAM-1, MCP-1 and TNF-alpha were assessed by enzyme
      linked immunosorbent assay kits. Significant associations between systemic
      factors and quantitative and qualitative spectral-domain optical coherence
      macular features were analyzed. RESULTS: A mean of 4.82 +/- 0.56 intravitreal
      injections was performed, resulting in significant improvement of central foveal
      thickness (CFT) (p < 0.001). A significant association with third month CFT
      decrease <10% was found for hsCRP (3.33 +/- 2.01 vs 1.39 +/- 1.15 mg/l, p =
      0.007) and ICAM1 (975.54 +/- 265.49 vs 727.07 +/- 336.09 pg/ml, p = 0.012). ROC
      curve analysis indicated hsCRP and ICAM1 as significant biomarkers for 3rd month
      reduced anatomic response (area under the curve (AUC) = 0.807, p = 0.009 for
      hsCRP; AUC = 0.788, p = 0.014 for ICAM1). ROC curve analysis revealed hsCRP as a
      significant biomarker for 6th month CFT decrease <10% (AUC = 0.903, p < 0.001,
      cutoff value = 1.81 mg/l). A significant association with 6th month CFT decrease
      >=25% was found for serum MCP1 (244.69 +/- 49.34 pg/ml vs 319.24 +/- 94.88 pg/ml,
      p = 0.017) and serum VEGF (90.84 +/- 37.33 vs 58.28 +/- 25.19 pg/ml, p = 0.027).
      The combined model of serum VEGF and LDL-cholesterol was found to be predictive
      of 6th month hard exudate severity (p = 0.001, r2 = 0.463). CONCLUSIONS:
      Increased levels of hsCRP and ICAM1 were found to be significant biomarkers for
      early reduced anatomic response to anti-VEGF treatment. Cases with higher serum
      levels of such factors had increased CFT values, despite treatment, suggesting
      inner blood-retinal barrier breakdown that is not adequately responsive to anti
      VEGF monotherapy.

PMID- 29843963
TI  - Cognitive and behavioral functioning and quality of life in older adults.

PMID- 29843965
TI  - New Components of the Lignin Biosynthetic Metabolon.
AB  - Lignin biosynthetic enzymes form a complex on the ER. Here we highlight how the
      recent identification of the membrane steroid binding proteins (MSBPs) as the
      structural component of the complex have revealed the molecular mechanism
      underlying the monolignol metabolon formation.

PMID- 29843966
TI  - CD59 deficiency presenting as polyneuropathy and Moyamoya syndrome with
      endothelial abnormalities of small brain vessels.
AB  - CD59 is involved in lymphocyte signal transduction and regulates complement
      mediated cell lysis by inhibiting the membrane attack complex. In the cases
      reported so far, congenital isolated CD59 deficiency was associated with
      recurrent episodes of hemolytic anemia, peripheral neuropathy, and strokes. Here,
      we report on a patient from a consanguineous Turkish family, who had a first
      episode of hemolytic anemia at one month of age and presented at 14 months with
      acute Guillain-Barre syndrome (GBS). The child suffered repeated infection
      triggered relapses leading to the diagnosis of chronic inflammatory demyelinating
      polyneuropathy (CIDP). Although partly steroid-responsive, the polyneuropathy
      failed to be stabilized by a number of immunosuppressive agents. At the age of 6
      years, he developed acute hemiparesis and showed progressive stenosis of proximal
      cerebral arteries, evolving into Moyamoya syndrome (MMS) with recurrent
      infarctions leading to death at 8 years of age. Post-mortem genetic analysis
      revealed a pathogenic p.(Asp49Valfs*31) mutation in CD59. Re-analysis of brain
      biopsy specimens showed absent CD59 expression and severe endothelial damage.
      Whereas strokes are a known feature of CD59 deficiency, MMS has not previously
      been described in this condition. Therefore, we conclude that in MMS combined
      with hemolysis or neuropathy CD59 deficiency should be considered. Establishing
      the diagnosis and targeted therapy with eculizumab might have prevented the
      lethal course in our patient.

PMID- 29843967
TI  - The value of the doctorate dissertation seminar to personal development.

PMID- 29843964
TI  - Latent toxoplasma infection in real-world schizophrenia: Results from the
      national FACE-SZ cohort.
AB  - OBJECTIVE: Latent Toxoplasma infection has been associated with widespread brain
      immune activation, increased blood brain barrier permeability, neural disruption,
      increased dopamine release in dopaminergic neurons, with NMDA activation and with
      schizophrenia (SZ) onset risk. Toxoplasma has been suggested to be a source of
      chronic low-grade inflammation and this inflammation has been associated with
      cognitive impairment in SZ. The objective of the present study were (i) to
      determine if latent Toxoplasma infection was associated with specific clinical
      features in stabilized SZ subjects, with cognitive impairment and with increased
      low-grade peripheral inflammation and (ii) to determine if Treatments with Anti
      Toxoplasmic Activity (TATA) were associated with improved outcomes in subjects
      with latent Toxoplasma infection. METHODS: A comprehensive 2 daylong clinical and
      neuropsychological battery was administered in 250 SZ subjects included between
      2015 and 2017 in the national FondaMental Expert Center (FACE-SZ) Cohort. Solid
      phase-enzyme microplate immunoassay methods were used to measure IgG class of
      antibodies to T. gondii in blood sample. Latent Toxoplasma infection was defined
      by T. gondii IgG ratio >=0.8, equivalent to >=10 international units. Chronic
      peripheral inflammation was defined by highly sensitive C reactive protein blood
      level >= 3 mg/L. RESULTS: Latent Toxoplasma infection has been found in 184
      (73.6%) of this national multicentric sample. In the multivariate analyses,
      latent Toxoplasma infection has been significantly associated with higher PANSS
      negative (aOR = 1.1 [1.1-1.1], p = 0.04) and excitement subscores (aOR = 1.3 [1.1
      1.6], p = 0.01), with two specific symptoms (i.e., reference delusion (aOR = 3.6
      [1.2-10.6] p = 0.01) and alogia (aOR = 16.7 [2.0-134.7], p = 0.008)) and with
      chronic low-grade peripheral inflammation (27.2% vs. 7.6%, aOR = 3.8 [1.4-10.3],
      p = 0.004). Extrapyramidal symptoms remained significantly associated with latent
      Toxoplasma infection. On the opposite, no significant association of latent
      Toxoplasma infection with age, gender, age at SZ onset, suicide behavior or
      cognitive deficits has been found in these models (all p > 0.05). TATA were
      associated with lower depressive symptoms (aOR = 0.8[0.7-0.9], p = 0.01), and
      with lower rates of chronic peripheral inflammation (20.9% vs. 48.6%, aOR = 3.5
      [1.5-7.9], p = 0.003) but not with higher cognitive scores (p > 0.05).
      CONCLUSION: The present findings suggest that Toxoplasma is almost 3 times more
      frequent in SZ population compared to general population in France. The potential
      cerebral underpinnings of the association of latent Toxoplasma infection and the
      above-mentioned outcomes have been discussed. Future studies should confirm that
      TATA may be effective to reduce Toxoplasma-associated depressive symptoms and low
      grade peripheral inflammation.

PMID- 29843968
TI  - Reasonable cholecystectomy of gallbladder polyp - 10 years of experience.
AB  - BACKGROUND AND OBJECTIVE: Although the incidence of carcinoma is not high in
      gallbladder polyps, it is essential to diagnose gallbladder cancer at an early
      stage to achieve a good therapeutic outcome. Therefore, the aim of this study was
      to define the characteristics of gallbladder polyps to establish sound criteria
      for surgical indications. METHODS: In the current study, data from 516 patients
      with gallbladder polyps who underwent cholecystectomy were reviewed to correlate
      clinical features with histopathologic findings and identify risk factors with
      receiver-operating characteristic curves (ROCs). RESULTS: Among the 516 patients
      who underwent cholecystectomy, 24 patients (4.6%) had cancerous change. The
      cancer group was significantly older (65.5 years (median, range 35-85)) than the
      non-cancer group (42 years (median, range 23-82)) (p < 0.001). Among the cancer
      group, the preoperative polyp size on ultrasonography was significantly larger
      (14 mm (median, range 9-30)) than the polyps in the non-cancer group (10.4 mm
      (median, range 1.9-45)) (p < 0.001). Using the ROC curve and considering the
      sensitivity and specificity for predicting malignant polyps, 12 mm may be a
      reasonable cutoff for considering a malignant polyp. CONCLUSIONS: Gallbladder
      polyps with 10-11 mm in asymptomatic young patients (less than 50 years old) have
      low risk of malignancy, and therefore, a careful "wait and see with follow up by
      using ultrasonography strategy" might be more appropriate than immediate
      cholecystectomy.

PMID- 29843969
TI  - Adolescent Health Providers' Willingness to Prescribe Pre-Exposure Prophylaxis
      (PrEP) to Youth at Risk of HIV Infection in the United States.
AB  - PURPOSE: HIV disproportionately affects young men who have sex with men. Pre
      exposure prophylaxis (PrEP) can prevent HIV acquisition; however, youth access to
      PrEP is limited by provider willingness to prescribe PrEP. METHODS: We conducted
      an online survey of clinicians working with adolescents (aged 13-17 years) and
      young adults (aged 18-26 years) in the United States through the Society of
      Adolescent Health and Medicine. We used multivariate logistic regression to
      assess provider beliefs associated with willingness to provide PrEP. RESULTS:
      Nearly all (93.2%) providers had heard of PrEP, and 57 (35.2%) had prescribed
      PrEP. While almost all providers (95%) agreed that PrEP prevents HIV, fewer were
      willing to prescribe to young adults (77.8%) or adolescents (64.8%). Willingness
      to prescribe PrEP was strongly associated with the belief that providers had
      enough knowledge to safely provide PrEP to adolescents (OR 2.11, confidence
      interval [CI]: 1.18-3.76, p = .01) and young adults (odds ratio 5.19, CI: 2.15
      12.50, p <= .001), and that adolescents would be adherent (odds ratio 3, CI: 1.30
      6.90, p = .01). Response rate was 17%. CONCLUSIONS: Almost all providers had
      heard of PrEP and most providers were willing to prescribe PrEP. Provider
      education and tools to promote provider self-efficacy and adolescent adherence
      might improve provider willingness to provide PrEP.

PMID- 29843970
TI  - [Venous invasions in colonic adenocarcinoma: Value of elastic stain].
AB  - : The aim of our study was to assess the value of Elastic stain in the diagnosis
      of venous invasion (VI) in colonic adenocarcinoma. MATERIAL AND METHODS: All
      patients who undergone surgery for colonic adenocarcinoma at the University
      Hospital of Amiens, between 2004 and 2007, were included. Hematein-phloxin
      saffron (HPS) stained slides of colectomy specimens were reviewed by two
      pathologists. Tumor blocks were stained with Elastic Stain (Roche - Ventana(r)).
      The presence or absence of VI, their number and localization were correlated with
      overall survival. RESULTS: Two hundred and thirty-one cases were investigated and
      3274 slides were examined. VI were more often diagnosed by Elastic Stain than HPS
      stain (66% vs. 40%). Ninety percent of VI were revealed within the first 6 HPS
      slides, and from the first 5 in Elastic Stain. The presence of VI revealed by
      Elastic Stain and/or HPS was significantly associated with decreased overall
      survival in multivariate analysis (P=0.029), especially for stage IIA tumors
      (P=0.016). Tumor differentiation (P=0.006) and pTNM stage (P=0.001) were also
      independent prognostic factors. The localization and the number of VI were not
      prognostic factors. CONCLUSION: Our study confirms the prognostic value of VI,
      revealed by an elastic stain, in colonic adenocarcinoma. A systematic elastic
      stain of all tumor blocks (number at least 5) could be considered in the future,
      during pathological examination of colectomy for adenocarcinoma.

PMID- 29843971
TI  - [Learning pathologic anatomy during medical formation: Understanding the
      contribution of the motivation].
AB  - INTRODUCTION: The motivations of medical students for Pathologic Anatomy are
      little known although they can strongly influence their academic performance. Our
      work focused on the analysis of the relationship between performance and
      motivation for Pathologic Anatomy. MATERIALS AND METHODS: Second-year students
      (n=268) from the University of Nantes were contacted to complete a motivation
      questionnaire and to provide indicators of performance and attendance. The
      responses were analyzed in order to establish the psychometric reliability and
      the factorial structure of the questionnaire. The relationship between motivation
      and performance was explored by correlation and by linear regression studies. A
      cluster analysis was performed to specify the distribution of the two variables
      in our sample. RESULTS: The sample corresponded to 168 respondents with a F/M
      ratio similar to that of our population. Our data demonstrated the reliability of
      the questionnaire and a structure described by 5 motivation factors (self
      determination, self-efficacy, career, grade and intrinsic motivation). The
      academic performance was not significantly correlated with the overall motivation
      or with student attendance. However, it was predicted by self-determination and
      self-efficacy. Our work revealed gender differences as well as the existence of
      two distinct clusters defined by the motivation and performance of the students.
      DISCUSSION/CONCLUSION: This work constitutes the first study of the motivations
      of French medical students for cyto-pathology. It validates a quantitative
      assessment tool for motivation. Finally, it explores the heterogeneity of the
      distribution of motivation and academic performance within a population of
      learners.

PMID- 29843972
TI  - Pathology assessment of pancreatic cancer following neoadjuvant treatment: Time
      to move on.
AB  - Neoadjuvant treatment has increasingly become an integral part of the multimodal
      management of patients with pancreatic cancer. In patients who are able to
      undergo surgery following preoperative therapy, tumour regression grading remains
      the diagnostic gold standard for the histomorphological assessment of the effect
      of neoadjuvant treatment. In recent years, however, there has been growing
      concern about inherent flaws of tumour regression grading systems as well as
      their imprecise and impractical criteria that result in divergence of practice
      and lack of interobserver agreement. Furthermore, existing tumour regression
      systems differ in their defining criteria and thresholds, leading to
      incomparability of data. In this review, the principles and limitations of the
      main existing tumour regression systems are discussed, and potential alternative
      assessment approaches and novel markers are presented.

PMID- 29843973
TI  - Prevalence and Outcomes of Undiagnosed Peripheral Arterial Disease Among High
      Risk Patients in Australia: An Australian REACH Sub-Study.
AB  - BACKGROUND: Compared with other manifestations of cardiovascular disease,
      peripheral arterial disease (PAD) is under-diagnosed. This study aims to
      investigate the prevalence, risk profile and cardiovascular outcomes of
      undiagnosed PAD in Australian general practices. METHOD: A sub-study of the
      Australian Reduction of Atherothrombosis for Continued Health (REACH) Registry, a
      prospective cohort study of patients at high risk of atherothrombosis recruited
      from Australian general practices. Eligible patients for this study had no
      previous clinical diagnosis of PAD and had an ankle-brachial index (ABI) <=1.4 at
      recruitment. RESULTS: Peripheral arterial disease was undiagnosed in 34%
      Australian REACH participants, 28% patients had low ABI (ABI<0.9) and 11% had
      intermittent claudication (IC) based on responses to the Edinburgh Claudication
      Questionnaire (ECQ). We found no significant differences in risk factor control
      between patient with or without PAD. Intermittent claudication patients had
      higher risks of non-fatal cardiovascular events and PAD interventions at one
      year, whereas all-cause mortality rate was higher among patients with ABI<0.9,
      especially in those who also reported IC. Finally, an ABI<0.9, together with
      poorly controlled risk factors were independent predictors of incident IC at one
      year. CONCLUSIONS: This study suggests a high rate of undiagnosed PAD among high
      risk patients in Australian primary health care. These patients are at high risk
      of events and therefore would potentially benefit from better secondary
      prevention measures.

PMID- 29843974
TI  - Prognostic Importance of Increased Right Ventricular Afterload in Orthotopic
      Liver Transplantation Recipients with Endstage Cirrhosis.
AB  - BACKGROUND: Severely increased right ventricular (RV) afterload is considered a
      contra-indication for orthotopic liver transplantation (OLT). This study assesses
      the effects of mildly increased RV afterload on long-term outcome after OLT in
      relation to RV function. METHODS: 139 OLT recipients (53+/-12years, 76% male)
      were included. Preoperative RV afterload was assessed invasively or, if not
      available, echocardiographically and categorised as normal, high-normal (mean
      pulmonary artery pressure [PAP] 20-25mmHg or echocardiographic systolic PAP 35
      40mmHg) or mildly elevated (mean PAP 25-35mmHg or systolic PAP 40-50mmHg). The
      association between level of RV afterload, echocardiographic RV function and
      postoperative outcome was assessed. RESULTS: Right ventricular afterload was high
      normal in 17% and mildly elevated in 12% of patients. Patients with elevated RV
      afterload had higher echocardiographic RV dimensions and left ventricular filling
      pressures. RV functional parameters were within normal range and not associated
      with RV afterload. Increased RV afterload was associated with a higher incidence
      of postoperative haemodynamic complications (8%, 17%, and 29% for normal, high
      normal and mildly elevated RV afterload, respectively, p=0.03) and worse survival
      (8-year survival 74%, 41% and 37% respectively, p=0.01). Preoperative RV function
      was not associated with outcome after OLT. CONCLUSIONS: Increased RV afterload
      was associated with increased haemodynamic complications and worse long-term
      survival in OLT recipients. Right ventricular function in patients with increased
      RV afterload was within normal range and not associated with postoperative
      outcome.

PMID- 29843975
TI  - Comorbidities and Ventricular Dysfunction Drive Excess Mid-Term Morbidity in an
      Indigenous Australian Coronary Revascularisation Cohort.
AB  - BACKGROUND: There is a paucity of data in regards to longer term morbidity
      outcomes in Indigenous Australian patients undergoing coronary artery bypass
      grafting (CABG). No comparative data on re-infarction, stroke or reintervention
      rates exist. Outcome data following percutaneous coronary intervention (PCI) is
      also extremely limited. Addressing this gap in knowledge forms the major aim of
      our study. METHODS: This was a single centre cohort study conducted at the
      Townsville Hospital, Australia which provides tertiary adult cardiac surgical
      services to the northern parts of the state of Queensland. It incorporated
      consecutive patients (n=350) undergoing isolated CABG procedures, 2008-2010,
      20.9% (73/350) of whom were Indigenous Australians. The main outcome measures
      were major adverse cardiac or cerebrovascular events (MACCE) at mid-term follow
      up (mean 38.9 months). RESULTS: The incidence of MACCE among Indigenous
      Australian patients was approximately twice that of non-Indigenous patients at
      mid-term follow-up (36.7% vs. 18.6%; p=0.005; OR 2.525 (1.291-4.880)). Following
      adjustment for preoperative and operative variables, Indigenous Australian status
      itself was not significantly associated with MACCE (AOR 1.578 (0.637-3.910)).
      Significant associations with MACCE included renal impairment (AOR 2.198 (1.010
      4.783)) and moderate-severe left ventricular impairment (AOR 3.697 (1.820
      7.508)). An association between diabetes and MACCE failed to reach statistical
      significance (AOR 1.812 (0.941-3.490)). CONCLUSIONS: Indigenous Australians
      undergoing CABG suffer an excess of MACCE when followed-up in the longer term.
      High rates of comorbidities in the Indigenous Australian population likely play
      an aetiological role.

PMID- 29843976
TI  - Comparison of standard renal denervation procedure versus novel distal and branch
      vessel ablation with brachial arterial access.
AB  - OBJECTIVES: We assessed a novel approach to percutaneous renal denervation for
      uncontrolled hypertension consisting of ablation beyond the proximal main renal
      artery (Y-pattern), including the primary branches, and compared it to the
      standard procedure applied only within the main vessel. We also assessed the
      safety and practicality of a brachial access approach. METHODS AND RESULTS: Renal
      denervation was performed on 119 consecutive patients (60 +/- 13 years). In 68 of
      the patients, femoral arterial vascular approach was used and in 51 brachial. In
      80 patients treated with the standard ablation, 12.0 +/- 3.0 total ablations
      (both sides) were applied while 20.4 +/- 3.9 total ablations were delivered for
      the group of 39 patients with Y-pattern denervation (P < 0.001). Technically
      successful renal denervation was achieved in all patients. Office blood-pressure
      levels at baseline were 170 +/- 17/93 +/- 10 mm Hg for the standard group and 169
      +/- 13/96 +/- 9 mm Hg for the Y-pattern group. No major adverse events occurred
      during the procedure or in the postprocedural in-hospital period. Renal
      denervation was associated with significant decreases in both office and
      ambulatory systolic and diastolic blood pressure in both groups. The reduction in
      24-hour mean ambulatory systolic blood pressure at 6 months was significantly
      greater (P = 0.002) for the Y-Pattern group (-22.1 +/- 15.4 mm Hg) compared to
      the Standard group (-11.8 +/- 16.2 mm Hg). Changes in diastolic office and
      ambulatory pressure were also significantly greater at 6 months in the Y-pattern
      ablation group. Indices of blood pressure variability improved in both groups.
      CONCLUSION: Renal denervation using a Y-pattern ablation strategy combined with a
      greater number of lesions is safe and resulted in significant greater decreases
      in mean 24-hour ambulatory systolic and diastolic blood pressure compared to the
      conventional approach in this single-centre matched cohort study. Brachial artery
      access was shown to be feasible and safe for renal denervation.

PMID- 29843977
TI  - Type 2 diabetes: A protective factor for COPD?
AB  - BACKGROUND: Chronic obstructive pulmonary disease (COPD) and type 2 diabetes
      (T2DM) are common comorbidities. COPD is a known risk factor for incident T2DM,
      however few studies have examined the relationship in reverse. The primary aim of
      this study was to compare the incidence of COPD in people with and without T2DM.
      MATERIALS AND METHODS: We conducted a retrospective case-control study using a
      long-established English general practice network database (n=894,646). We
      matched 29,217 cases of T2DM with controls, adjusting for age, gender, smoking
      status, BMI and social deprivation, to achieve 1:1 propensity matching and
      compared the rate of incident COPD over eight years of follow-up. We performed a
      secondary analysis to investigate the effect of insulin, metformin and
      sulphonylureas on COPD incidence. RESULTS: People with T2DM had a reduced risk of
      COPD compared to matched controls over the follow-up period (HR 0.89, 95%CI 0.79
      0.93). 48.5% of those with T2DM were ex-smokers compared with 27.3% of those
      without T2DM. Active smoking rates were 20.4% and 23.7% respectively. Insulin,
      metformin and sulphonylureas were not associated with incident COPD. CONCLUSIONS:
      People with T2DM are less likely to be diagnosed with COPD than matched controls.
      This may be due to positive lifestyle changes, such as smoking cessation in those
      with T2DM.

PMID- 29843978
TI  - Piezoelectric surgery versus conventional drilling for implant site preparation:
      a meta-analysis.
AB  - PURPOSE: To answer the PICO question: "Among patients to whom an implant is
      placed, does the piezoelectric surgery (PS) compared to the conventional drilling
      (CS) achieve higher implant stability, increase surgical time or improve implant
      survival rate?" STUDY SELECTION: Two independent authors screened the literature
      through MEDLINE, Cochrane Library and Scopus. Randomized or non-randomized
      controlled trials, prospective and retrospective cohort studies comparing implant
      stability and/or clinical outcomes with PS versus CS used for implant site
      preparation published in the last 10 years were included in the search. RESULTS:
      Five of the 177 articles initially found were included in the meta-analysis. No
      statistically significant differences were found between PS and CS for implant
      stability quotient (ISQ) at baseline (SMD: 0.31; 95 %CI: -0.59 to 1.20; p=0.5).
      However, ISQ values were significantly higher at 2 months (SMD: 0.52; 95 %CI:
      0.03-1.00; p=0.04) and at 3 months (SMD: 0.74; 95 %CI: 0.17-1.32; p=0.01) for CS.
      PS needed significantly more time than CS (SMD: 1.74; 95 %CI: 0.42-3.06; p=0.01)
      in order to be performed. No differences for implant survival rates were found
      when comparing both techniques (RR: 0.52; 95 %CI: 0.09-2.88; p=0.45).
      CONCLUSIONS: PS has not demonstrated superiority to conventional drilling for
      implant stability during the healing period. PS needs significantly longer
      surgery time than CS. Differences for implant survival rate were not found
      between the two techniques.

PMID- 29843979
TI  - Staphylococcus aureus requires less virulence to establish an infection in
      diabetic hosts.
AB  - Staphylococcus aureus is the most frequent pathogen causing diabetic foot
      infections. Here, we investigated the degree of bacterial virulence required to
      establish invasive tissue infections in diabetic organisms. Staphylococcal
      isolates from diabetic and non-diabetic foot ulcers were tested for their
      virulence in in vitro functional assays of host cell invasion and cytotoxicity.
      Isolates from diabetes mellitus type I/II patients exhibited less virulence than
      isolates from non-diabetic patients, but were nevertheless able to establish
      severe infections. In some cases, non-invasive isolates were detected deep within
      diabetic wounds, even though the strains were non-pathogenic in cell culture
      models. Testing of defined isolates in murine footpad injection models revealed
      that both low- and high-virulent bacterial strains persisted in higher numbers in
      diabetic compared to non-diabetic hosts, suggesting that hyperglycemia favors
      bacterial survival. Additionally, the bacterial load was higher in NOD mice,
      which have a compromised immune system, compared to C57Bl/6 mice. Our results
      reveal that high as well as low-virulent staphylococcal strains are able to cause
      soft tissue infections and to persist in diabetic humans and mice, suggesting a
      reason for the frequent and endangering infections in patients with diabetes.

PMID- 29843980
TI  - Functional analysis reveals differential effects of glutamate and MCH
      neuropeptide in MCH neurons.
AB  - OBJECTIVES: Melanin-concentrating hormone (MCH) neurons in the lateral
      hypothalamus (LH) regulate food intake and body weight, glucose metabolism and
      convey the reward value of sucrose. In this report, we set out to establish the
      respective roles of MCH and conventional neurotransmitters in these neurons.
      METHODS: MCH neurons were profiled using Cre-dependent molecular profiling
      technologies (vTRAP). MCHCre mice crossed to Vglut2fl/flmice or to DTRfl/flwere
      used to identify the role of glutamate in MCH neurons. We assessed metabolic
      parameters such as body composition, glucose tolerance, or sucrose preference.
      RESULTS: We found that nearly all MCH neurons in the LH are glutamatergic and
      that a loss of glutamatergic signaling from MCH neurons from a glutamate
      transporter (VGlut2) knockout leads to a reduced weight, hypophagia and
      hyperkinetic behavior with improved glucose tolerance and a loss of sucrose
      preference. These effects are indistinguishable from those seen after ablation of
      MCH neurons. These findings are in contrast to those seen in mice with a knockout
      of the MCH neuropeptide, which show normal glucose preference and do not have
      improved glucose tolerance. CONCLUSIONS: Overall, these data show that the vast
      majority of MCH neurons are glutamatergic, and that glutamate and MCH signaling
      mediate partially overlapping functions by these neurons, presumably by
      activating partially overlapping postsynaptic populations. The diverse functional
      effects of MCH neurons are thus mediated by a composite of glutamate and MCH
      signaling.

PMID- 29843981
TI  - Blind biliary limb dilatation (Candy cane syndrome) of jejuno-jejunal anastomosis
      after Roux en Y Gastric Bypass (with video).

PMID- 29843982
TI  - Operative technique: Robotic transaxillary thyroid lobectomy.

PMID- 29843983
TI  - HbA1c and retinal sensitivity in diabetics using microperimetry.
AB  - PURPOSE: The purpose of this study was to determine the relationship between
      HbA1c values and retinal sensitivity at central 10 degrees  using the MP-1
      microperimeter. METHODS: A prospective study was carried out on 32 healthy
      subjects (control group) and 60 diabetic patients. The diabetic patients were
      divided into 2 groups. Group 1 comprised of 30 patients without diabetic
      retinopathy (DR) and group 2 had 30 patients with mild non-proliferative DR. A
      full-threshold microperimetry of the central 10 degrees  of retina (the macula)
      was performed on all subjects, utilizing 32 points with the MP-1. The
      relationship between light sensitivity and HbA1c value was calculated using
      linear regression analysis. RESULTS: Total mean sensitivity at 10 degrees  for
      group 1 without DR, group 2 with mild NPDR and control group were 18.67+/-0.83,
      17.98+/-1.42 and 19.45+/-0.34 (dB), respectively. There was a significant
      difference in total mean retinal sensitivity at 10 degrees  between the 3 groups
      (F(2,89)=18.14, p=0.001). A simple linear regression was calculated to predict
      HbA1c based on retinal sensitivity. A significant regression equation was found
      (F(1,90)=107.61, p=0.0001, with an R2 of 0.545). The linear regression analysis
      revealed that there was a 0.64dB decline in mean retinal sensitivity within the
      central 10 degrees  diameter with an increase of 1mmHg of HbA1c. CONCLUSION:
      Retinal sensitivity at the central 10 degrees  of the macula is affected by
      changes in HbA1c values.

PMID- 29843984
TI  - Comparison of clinical characteristics of radiological forms of autoimmune
      pancreatitis.
AB  - BACKGROUND: There is limited understanding of the clinical characteristics of
      different radiological forms of autoimmune pancreatitis (AIP). This retrospective
      study compared the clinical features of radiological forms of AIP. METHODS: A
      retrospective review was conducted of patients with AIP treated from 2005 to
      2015. Based on radiological features, these AIP cases were classified as diffuse
      (D) or focal (F), and the latter further stratified as head (H), or body and/or
      tail (B/T). The clinical characteristics and laboratory indices were compared.
      RESULTS: Among the 119 patients, 66 (55.5%), 40 (33.6%), and 13 (10.9%) were
      respectively classified as D-, H-, and B/T-type. Compared with the others, the
      B/T-type patients were younger at onset, the percentage of men was lower, loss of
      appetite and weight were less common, and these patients had fewer
      extrapancreatic lesions (P < 0.05, each). Compared with the other groups, the B/T
      type patients showed significantly lower levels of liver enzymes, direct
      bilirubin, and total bilirubin. No B/T-type patient displayed jaundice or
      pruritus. Three B/T-type patients progressed to D-type during the natural course
      of illness. CONCLUSIONS: D-type and H-type AIP patients had similar clinical
      features. The B/T-type group differed significantly from the other two types. B/T
      type can progress to D-type.

PMID- 29843985
TI  - Intrapancreatic accessory spleen: a diagnostic dilemma.
AB  - BACKGROUND: As intrapancreatic accessory spleen (IPAS) is rarely encountered
      during clinical practice, the aim of this review was to summarize the
      epidemiologic features, the diagnosis and treatment of IPAS. METHODS: MEDLINE and
      EMBASE were searched for articles reporting on IPAS. Categorical variables were
      reported as frequency and percentage. Continuous variables were reported as
      median (range). RESULTS: A total of 105 patients were included, of which 73% were
      detected incidentally. The male/female ratio was 1.23. The size of IPAS in
      patients who had previously undergone splenectomy was larger than that of
      patients without prior splenectomy (2.5 cm vs 1.5 cm; p = 0.020). No preoperative
      examination was able to make a definite diagnosis for all IPASs. More than half
      of the patients (55%) received surgical treatment, most of which (87%) were
      suspected as pancreatic neuroendocrine tumors (p-net) preoperatively.
      CONCLUSIONS: Although rare, IPAS should be considered in the differential of
      patients with suspected incidental p-net, especially if there has been a past
      history of splenectomy. Preoperative diagnosis is important as unnecessary
      surgery can be avoided. As it is difficult to make a definite diagnosis of IPAS
      by one single examination, multiple techniques may be required.

PMID- 29843986
TI  - Intention-to-treat analysis of liver transplantation, resection and thermal
      ablation for hepatocellular carcinoma in a single centre.
AB  - BACKGROUND: potentially curative treatment options for hepatocellular carcinoma
      (HCC) include liver transplantation (LT), liver resection (LR) and thermal
      ablation (TA). Long term intent-to-treat (ITT) analysis from a single-centre
      using all three modalities contemporaneously has not been published. METHODS: An
      ITT analysis was undertaken of all patients with HCC listed for LT, or have
      undergone LR or TA. RESULTS: 444 patients were identified; 145 were listed for LT
      (121 underwent LT), 190 underwent LR and 109 underwent TA. One and 3-year overall
      survival (OS) was similar among LT, LR and TA (88/77%, 88/64% and 95/72%) whereas
      5-year OS was higher following LT than LR or TA (73% vs. 54% vs. 49%). Disease
      free survival at 1- and 5-years was higher for LT (97% and 84%) than LR (66% and
      35%) or TA (73%, and 19%). CONCLUSION: LT offered the lowest rate of cancer
      recurrence and highest chance of long-term survival. Differences in outcome
      likely reflect a combination of cancer-related factors (AFP, micro- and
      macrovascular invasion), patient-related factors (performance status, co
      morbidities and psychosocial issues) and treatment type. Two thirds of patients
      treated by LR and three quarters treated by TA had HCC recurrence by 5 years,
      reinforcing the need for close long-term surveillance.

PMID- 29843987
TI  - Patterns of Distant Failure by Intrinsic Breast Cancer Subtype in Premenopausal
      Women Treated With Neoadjuvant Chemotherapy.
AB  - PURPOSE: To identify patterns of distant failure (DF) in premenopausal women
      receiving neoadjuvant chemotherapy (NAC) for breast cancer. PATIENTS AND METHODS:
      Premenopausal patients treated with NAC between 2005 and 2015 at a single
      institution were retrospectively reviewed. Timing and location of local,
      regional, and distant metastases were described. Predictors for DF and overall
      survival (OS) were analyzed. RESULTS: Of 225 patients, there were 24 (10.7%)
      local, 30 (13.3%) regional, and 63 (28.0%) distant recurrences. Cumulative
      incidence of DF was higher in patients younger than age 40 (P = .01), in those
      with residual tumor size > 2 cm (P < .0001), in those with positive lymph nodes
      after NAC (P = .0003), and in those without pathologic complete response (P <
      .0001). Cumulative incidence of brain metastases was most common in patients with
      human epidermal growth factor receptor 2 (HER2)-positive disease (P = .05). Time
      from development of metastatic disease to death varied by breast cancer subtype
      (P = .019), as did 5-year OS (P = .024). Women with HER2-positive and triple
      negative disease had the highest incidence of brain metastases and the shortest
      time from development of metastases to death. On multivariable analysis, luminal
      B subtype (P = .025), pathologic complete response (P = .0014), young age (P =
      .0008), lack of hormone therapy (P < .0001), lymphovascular space involvement (P
      < .0001), and pathologic size of the primary tumor (P < .0001) were all
      significant predictors for DF. CONCLUSION: Patterns of DF after NAC in
      premenopausal women vary by breast cancer subtype, with DF more common than
      locoregional failure. Young age remains an independent poor prognostic factor,
      and OS differs by breast cancer subtype.

PMID- 29843988
TI  - Oncologic Safety of Gonadotropin-Releasing Hormone Agonist for Ovarian Function
      Protection During Breast Cancer Chemotherapy.
AB  - BACKGROUND: Receipt of a gonadotropin-releasing hormone (GnRH) agonist has been
      reported to protect against ovarian failure. We sought to determine the oncologic
      effect of a GnRH agonist with chemotherapy for breast cancer patients. PATIENTS
      AND METHODS: Data from 1160 patients aged 20 to 40 years with stage I to III
      breast cancer who received chemotherapy from 5 hospitals in Korea from 2002 to
      2012 were reviewed. A GnRH agonist was provided to 406 patients for ovarian
      protection during chemotherapy, and 754 patients received chemotherapy without
      ovarian protection. An individual score-matching strategy was used to create sets
      matched by age, tumor stage, hormone receptor status, neoadjuvant or adjuvant
      chemotherapy, and institute. RESULTS: Survival analysis by Cox regression showed
      that the GnRH agonist group had better distant metastasis-free survival (hazard
      ratio [HR], 0.59; 95% confidence interval [CI], 0.39-0.89) and disease-free
      survival (HR, 0.72; 95% CI, 0.52-0.99) than the chemotherapy-alone group. Among
      patients with hormone receptor-positive breast cancer, the benefit was
      significant for distant metastasis-free survival (HR, 0.53; 95% CI, 0.29-0.99)
      and disease-free survival (HR, 0.58; 95% CI, 0.35-0.96). CONCLUSION: Ovarian
      protection using a GnRH agonist can be safely considered for premenopausal breast
      cancer patients for whom chemotherapy is planned.

PMID- 29843989
TI  - Type testing of a locally made LiF:Mg,Ti + PTFE TLD for its use as a personal
      dosimeter.
AB  - Our research group has developed a thermoluminescence dosimeter (TLD) based on
      pellets of LiF:Mg,Ti mixed with polytetrafluoroethylene (LiF:Mg,Ti +PTFE). This
      TLD can be used as a personal dosimeter. Extensive type testing, carried out with
      reference to the International Electrotechnical Commission (IEC) Standard, were
      performed for the purpose of accepting the LiF:Mg,Ti+PTFE as a personal TL
      dosimeter. Tests performed include repeatability, batch homogeneity, linearity,
      detection threshold, and light sensitivity. Results showed that locally made
      LiF:Mg,Ti+PTFE TLDs met all the standard requirements.

PMID- 29843990
TI  - Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous
      Polyposis-Case Report and SEER Analysis.

PMID- 29843992
TI  - Editorial overview: Personality disorders: Personality pathology is what
      personality pathologists do.

PMID- 29843991
TI  - Lassa virus glycoprotein: stopping a moving target.
AB  - The structure of a prefusion arenavirus GPC was enigmatic for many years, owing
      to the metastable and non-covalent nature of the association between the receptor
      binding and fusion subunits. Recent engineering efforts to stabilize the
      glycoprotein of the Old World arenavirus Lassa in a native, yet cleaved state,
      allowed the first structure of any arenavirus prefusion GPC trimer to be
      determined. Comparison of this structure with the structures of other arenavirus
      glycoprotein subunits reveals surprising findings: that the receptor binding
      subunit, GP1, of Lassa virus is conformationally labile, while the GP1 subunit of
      New World arenaviruses is not, and that the arenavirus GPC adopts a trimeric
      state unlike other glycoproteins with similar fusion machinery. Structural
      analysis, combined with recent biochemical data regarding antibody epitopes and
      receptor binding requirements, provides a basis for rational vaccine design.

PMID- 29843993
TI  - A case control study on HDL associated PON1 enzyme level in Northern Indian type
      2 diabetes mellitus patients.
AB  - AIM: To evaluate the serum paraoxonase 1 activity and determine its association
      with duration in type 2 Diabetes mellitus patients. METHODS: A total of 80 cases
      from type 2 diabetes mellitus and healthy controls were enrolled in the present
      case control study. Human serum PON1 concentration was measured by ELISA and
      western blotting and it activity was determined spectrophotometrically using 4
      nitrophenyle acetate. Diagnostic accuracy of serum PON1 to identify type 2
      Diabetes mellitus was calculated with ROC analysis. RESULT: Serum concentration
      of LDL, VLDL, TG, A1C, FBS and TC levels showed significantly higher levels in
      type 2 diabetes patients as compared to healthy controls, however there were no
      significant differences found in the level of HDL. Serum PON1 concentration and
      activity monitored in patients with >1 year diabetes showed higher level (75.1 +/
      6.8 ng/mL) as compared to patients with >3 years diabetes (65.24 +/- 1.6 ng/mL),
      its level was further decreased in patients with >5 (53.8 +/- 2.6 ng/mL) and >7
      years (48.1 +/- 2.7 ng/mL) of diabetes. PON1 concentration decreased as the
      duration of diabetes increased. PON1 level was further decreased due to habits
      like smoking and alcohol consumption. CONCLUSION: Serum PON1 levels decrease in
      states of high oxidative stress like metabolic syndrome, obesity, uncontrolled
      diabetes, and dyslipidemia. It can be used as diagnostic marker for diabetes
      mellitus along with increased TG, LDL, VLDL and FBG.

PMID- 29843994
TI  - Autophagy and GLUT4: The missing pieces.
AB  - BACKGROUND: Autophagy is a process devoted to degrade and recycle cellular
      components inside mammalian cells through lysosomal system. It plays a main
      function in the pathophysiology of several diseases. In type 2 diabetes, works
      demonstrated the dual functions of autophagy in diabetes biology. Studies had
      approved the role of autophagy in promoting different routes for movement of
      integral membrane proteins to the plasma membrane. But its role in regulation of
      GLUT4 trafficking has not been widely observed. In normal conditions, insulin
      promotes GLUT4 translocation from intracellular membrane compartments to the
      plasma membrane, while in type 2 diabetes defects occur in this translocation.
      METHOD: Intriguing evidences discussed the contribution of different
      intracellular compartments in autophagy membrane formation. Furthermore,
      autophagy serves to mobilise membranes within cells, thereby promoting
      cytoplasmic components reorganisation. The intent of this review is to focus on
      the possibility of autophagy to act as a carrier for GLUT4 through regulating
      GLUT4 endocytosis, intracellular trafficking in different compartments, and
      translocation to cell membrane. RESULTS: The common themes of autophagy and GLUT4
      have been highlighted. The review discussed the overlapping of endocytosis
      mechanism and intracellular compartments, and has shown that autophagy and GLUT4
      utilise similar proteins (SNAREs) which are used for exocytosis. On top of that,
      PI3K and AMPK also control both autophagy and GLUT4. CONCLUSION: The control of
      GLUT4 trafficking through autophagy could be a promising field for treating type
      2 diabetes.

PMID- 29843995
TI  - Interaction between Albuminuria and Treatment Group Outcomes for Patients with
      Renal Artery Stenosis: The NITER Study.
AB  - PURPOSE: To perform a post-hoc analysis of the Nephropathy Ischemic Therapy
      (NITER) trial, which enrolled patients with atherosclerotic renal artery
      stenosis, to evaluate whether medical therapy plus stent placement is superior to
      medical therapy alone in patients without elevated albuminuria. MATERIALS AND
      METHODS: Data from 51 patients were analyzed and stratified into 2 cohorts by
      median urinary albumin (UAlb) levels: cohort 1 ("low albuminuria," UAlb <=0.04
      g/24h) and cohort 2 ("high albuminuria," UAlb >0.04g/24h). Interaction effect
      between treatment arms and UAlb cohorts was calculated using Cox regression
      analysis. Survival analysis was followed by test for effect size, power analysis,
      and construction of a Kaplan-Meier survival table. RESULTS: At study completion,
      13 patients had an outcome event: 6 (23%) from cohort 1 and 7 (28%) from cohort
      2. Patients in cohort 1 had event-free survival of 83% at 3.9 +/- 0.3 years from
      the primary endpoints of all-cause mortality, dialysis, and cardiovascular events
      when treated with interventional therapy, compared to 45% when treated with
      medical therapy alone (P = .501), which showed a 62% treatment effect for stent
      placement. In cohort 2, event-free survival rates were 64% for medical therapy
      versus 52% for medical plus interventional therapy (P = .64). Using Cox
      regression analysis, the interaction effect between treatment arms and UAlb
      cohorts was not significant (P = .32). The power of the study to detect an
      interaction effect, if one existed, was only 15%. CONCLUSIONS: Inference cannot
      be drawn for similar populations because of inadequate sample size, but, in this
      sample, patients treated with stent placement who had low albuminuria had better
      outcomes than patients treated with medical therapy alone.

PMID- 29843996
TI  - Radioembolization for Hepatocellular Carcinoma: A Nationwide 10-Year Experience.
AB  - PURPOSE: To examine the US nationwide experience with transarterial
      radioembolization (TARE) for hepatocellular carcinoma (HCC) in the years 2003
      2012 and the prognostic factors associated with overall survival. MATERIALS AND
      METHODS: A retrospective cohort study from the National Cancer Database included
      110,139 adult patients with HCC between 2003 and 2012, of whom 1,222 received
      TARE. Primary outcome of interest was mortality after treatment. Univariate and
      multivariate analyses for factors predicting mortality were performed for 961
      patients treated between 2003 and 2011. Overall survival was estimated by Kaplan
      Meier method. RESULTS: There was a steady increase in utilization of TARE in the
      past decade. Most patients were white men with median age of 64 years. Of those
      patients, 67% received treatment at an academic institution, 42% were American
      Joint Committee on Cancer stage I or II, and 10% had metastatic disease at the
      time of treatment. Median overall survival was 13.3 months. Overall survival
      varied by patient and tumor characteristics. Female patients with tumors < 5 cm
      or stage I or II disease benefited the most from treatment. Outcomes were the
      same across all age groups. Patients who were African American or had metastatic
      disease tended to have worse outcomes. CONCLUSIONS: Use of TARE in patients with
      HCC has been increasing. Several factors are significantly associated with a less
      favorable outcome after TARE, including male sex, large tumors, and extrahepatic
      disease. These data can be used for designing future radioembolization trials.

PMID- 29843997
TI  - Percutaneous Transanastomotic Stent Graft Deployment to Salvage Dysfunctional
      Native Forearm Radiocephalic Fistulae: Feasibility and Primary Patency at 12
      Months.
AB  - PURPOSE: To evaluate feasibility and efficacy of transanastomotic self-expandable
      polytetrafluoroethylene stent graft placement for salvage of radiocephalic
      arteriovenous fistulae (RCAVFs). MATERIALS AND METHODS: From 2008 to 2016, 26
      patients (21 male; age, 38-80 y) with dysfunctional RCAVFs for juxtaanastomotic
      lesions that were unresponsive to angioplasty underwent transanastomotic stent
      graft placement. Stenotic and thrombotic lesions were included. All were deemed
      unsuitable for surgical revision. Patency rates were calculated per Kaplan-Meier
      method. A Cox analysis was used to identify influencing factors. RESULTS: Thirty
      two stent grafts (6 patients had 2 stents) were deployed. Anatomic and clinical
      success were achieved in all patients; no major complications occurred.
      Mechanical and/or pharmacologic thrombolysis was performed in 6 cases before
      stent graft deployment. During follow-up (median, 34.7 mo; range, 1.9-102.7 mo),
      17 repeat interventions were required in 10 patients (43 procedures overall), for
      an endovascular intervention rate of 0.27 per year. At 3, 6, 12, and 24 months,
      primary patency (PP) rates were 96% +/- 4 (95% CI, 75%-99%), 83% +/- 7 (95% CI,
      61%-93%), 78% +/- 8 (95% CI, 55%-90%), and 69% +/- 10 (95% CI, 46%-84%). The
      corresponding assisted PP rates were 96% +/- 4 (95% CI, 76%-99%), 96% +/- 4 (95%
      CI, 76%-99%), 92% +/- 5 (95% CI, 71%-98%), and 82% +/- 8 (95% CI, 60%-93%). Five
      AVFs were ultimately abandoned. Per Cox analysis, arterial diameter >= 4 mm was
      associated with better PP (P = .032). CONCLUSIONS: Transanastomotic stent graft
      placement for RCAVF salvage is feasible and safe, providing patency rates
      comparable with historical endovascular and surgical data. Its role should be
      evaluated in larger studies.

PMID- 29843998
TI  - Combination drug treatment prolongs survival of experimentally infected mice with
      silver-haired bat rabies virus.
AB  - Rabies is a lethal disease in humans and animals, killing approximately 60,000
      people every year. Currently, there is no treatment available, except post
      exposure prophylaxis (PEP) that can be administered whenever exposure to a rabid
      animal took place. Here we describe the beneficial effects of a combination
      treatment initiated at day 4 post infection, containing anti-viral drugs and
      immune modulators in infected mice. Combination therapy resulted in significant
      increase in survival time (P < 0.05) and significantly lowers viral RNA in the
      brain and spinal cord (P < 0.05). Furthermore, treatment influenced markers of
      pyroptosis and apoptosis and early inflammatory response as measured by the
      levels of TNF-alpha. Morphological lesions were absent in rabies virus infected
      mice with few signs of inflammation. However, these were not significant between
      the different groups.

PMID- 29843999
TI  - Can genotype mismatch really affect the level of protection conferred by
      Newcastle disease vaccines against heterologous virulent strains?
AB  - Newcastle disease (ND), caused by virulent class II avian paramyxovirus 1
      (Newcastle disease virus, NDV), occurs sporadically in poultry despite their
      having been immunized with commercial vaccines. These vaccines were all derived
      from NDV strains isolated around 70 years ago. Since then, class II NDV strains
      have evolved into 18 genotypes. Whether the vaccination failure results from
      genotype mismatches between the currently used vaccine strains and field
      circulating velogenic strains or from an impaired immune response in the
      vaccination remains unclear. To test the first hypothesis, we performed a
      heterologous genotype II vaccine/genotype XI challenge in one-day old specific
      pathogen free (SPF) chicks and reproduced viral shedding. We then produced two
      attenuated strains of genotype II and XI by reverse genetics and used them to
      immunize two-week old SPF chickens that were subsequently challenged with
      velogenic strains of genotypes II, VII and XI. We found that both vaccines could
      induce antibodies with hemagglutination inhibition titers higher than 6.5 log2.
      Vaccination also completely prevented disease, viral shedding in swabs, and
      blocked viral replication in tissues from different genotypes in contrast to
      unvaccinated chickens that died shortly after challenge. Taken together, our
      results support the hypothesis that, in immunocompetent poultry, genotype
      mismatch is not the main reason for vaccination failure.

PMID- 29844000
TI  - Improved timely birth dose coverage of hepatitis B vaccine narrows the socio
      economic inequality in western China in 2011-2016.
AB  - OBJECTIVE: To compare timely birth dose (TBD) coverage of hepatitis B vaccine and
      socio-economic inequality distribution of TBD coverage between 2011 and 2016 in
      rural areas of western China. METHODS: In western China, using multi-stage
      probability proportion to size sampling, 2633 and 1929 children aged 0-35 months
      with an immunization card were selected from 14 rural counties in 2011 and 2016,
      respectively. Socio-economic characteristics were obtained from face-to-face
      questionnaire survey and copies of vaccination certificates. We performed
      multivariate logistic regression models to identify the determinants of TBD
      coverage of hepatitis B vaccine. We grouped TBD coverage by wealth quintiles,
      calculated inequality using the difference base on coverage in richest (quintile
      5) and poorest (quintile 1) household wealth quintiles. FINDINGS: From 2011 to
      2016, the overall TBD coverage of hepatitis B vaccine among children aged 0-35
      months in rural areas of western China increased from 52.8% (95% confidence
      interval, CI: 42.4-62.8) to 80.2% (95% CI: 69.5-87.8). The absolute difference in
      TBD coverage between richest and poorest quintiles was 20.6 (95%CI: 9.4-31.8) and
      15.8 (95%CI: 1.4-30.2) in 2011 and 2016, respectively. CONCLUSION: The
      socioeconomic inequality in TBD coverage decreased over the study period, but
      such inequality still existed in 2016. To improve inequality in TBD, the
      government should pay more attention to the disadvantaged groups, especially the
      children who were delivered at home, or whose caregivers were ethnic minority or
      who have a lower level of education.

PMID- 29844001
TI  - Docetaxel Down-Regulates PD-1 Expression via STAT3 in T Lymphocytes.
AB  - BACKGROUND: Lung tumor is a major cause of cancer incidence and patient death.
      Chemotherapy is the primary therapy used to treat lung cancer. In addition to
      direct cytotoxic effect on tumor cells, chemotherapeutic drugs activate immune
      responses to exert antitumor function. Here, the effects of docetaxel on the
      inhibitory molecules, programmed cell death 1 (PD-1), cytotoxic T-lymphocyte
      associated antigen 4 (CTLA-4), and T-cell immunoglobulin and mucin domain 3 (TIM
      3) in T lymphocytes were explored in patients with lung adenocarcinoma. PATIENTS
      AND METHODS: Peripheral blood mononuclear cells were isolated from lung
      adenocarcinoma patients receiving cisplatin-docetaxel chemotherapy. By flow
      cytometry and PCR, the expressions of CTLA-4, PD-1 and TIM-3 in T cell subsets
      were analyzed. Health subjects were used as control group. RESULTS: During
      chemotherapy, suppressive markers were down-regulated in peripheral CD4+ and CD8+
      T cells from patients with partial remission or stable disease. Additionally,
      interferon-gamma production was also augmented during this period. In vitro assay
      showed that docetaxel reduced the expression of PD-1 on T-cell subsets without
      altering cell death. Further tests in Jurkat T cells demonstrated that docetaxel
      activated signal transduction and activator of transcription 3 (STAT3) signaling
      to suppress PD-1 expression, whereas STAT3 inhibition reversed the down
      regulation of PD-1. CONCLUSION: Our data support the hypothesis that
      chemotherapeutic drugs are not only purely cytotoxic but are also immune
      modulators.

PMID- 29844002
TI  - Programmed Cell Death Ligand 1 Expression in Non-Small-cell Lung Cancer Patients
      With Interstitial Lung Disease: A Matched Case-control Study.
AB  - BACKGROUND: Programmed cell death protein 1 (PD-1)/programmed cell death ligand 1
      (PD-L1) checkpoint inhibitors have demonstrated antitumor activity, and
      immunohistochemical analysis of PD-L1 expression has been used to identify the
      response in patients with non-small-cell lung cancer (NSCLC). Recently,
      considerable interest has ensued toward extending the benefit of these inhibitors
      to high-risk patients, such as those with NSCLC and interstitial lung disease
      (ILD). However, no studies have compared PD-L1 expression in NSCLC patients with
      and without ILD. Therefore, we conducted a case-control study to evaluate PD-L1
      expression and stromal CD8+ lymphocyte density in these patients. MATERIALS AND
      METHODS: The data from patients with pathologic stage I or II NSCLC who had
      undergone surgery from January 2007 to January 2016 were analyzed. RESULTS: We
      identified 62 patients with pathologic stage I or II NSCLC and ILD. We compared
      these patients with 1:1-matched cohort. In both groups with and without ILD,
      approximately 60% were PD-L1+. Tumor cell PD-L1 expression was similar between
      the groups (median, 1%; interquartile range, 0%-5%; vs. median, 1%; interquartile
      range, 0%-5%; P = .49). The proportion of patients with positive (>= 1%) and
      strongly positive (>= 50%) PD-L1 expression was also similar between the 2 groups
      (P = .46 and P = 1.00, respectively). Additionally, the CD8+ lymphocyte density
      did not differ between patients with and without ILD. CONCLUSION: PD-L1
      expression and stromal CD8+ lymphocyte density were comparable between the NSCLC
      patients with and without ILD. PD-1 axis inhibitors might be effective for NSCLC
      patients with ILD.

PMID- 29844003
TI  - Antifungal susceptibility of clinical isolates of 25 genetically confirmed
      Aspergillus species collected from Taiwan and Mainland China.
AB  - BACKGROUND: To investigate the in vitro antifungal susceptibilities of 25
      genetically confirmed Aspergillus species collected from Taiwan and Mainland
      China. METHODS: A total of 390 non-duplicate and consecutive Aspergillus isolates
      representing of 25 species recovered from clinical sources at two teaching
      hospitals in Taiwan and Mainland china were preserved for this study. In vitro
      antifungal susceptibility testing (AFST) of those Aspergillus isolates against
      seven antifungal agents was performed using Sensititre YeastOne (SYO) system. The
      susceptibility profiles of isolates were analyzed according to the general
      interpretation code drawn from the SYO instruction. The CYP51A gene sequencing
      analysis was performed for triazole-resistant Aspergillusfumigatus isolates.
      RESULTS: Among the 390 Aspergillus isolates, 76.7% (n = 299) exhibited complete
      susceptibility to all the tested antifungals, and 23.3% (91/390) of different
      Aspergillus species isolates showed resistance to one or two classes of
      antifungal agents with higher minimum inhibitory concentrations (MICs) of >2
      mg/L. Resistance to amphotericin B was found in 91.2% (83/91) of those less
      susceptible isolates and most of them focused on species being resistant to
      Amphotericin B innately. The total rate of triazole resistance in this study was
      low (3.3%, 13/390), and only 3 (2.8%) A. fumigatus isolates were resistant to at
      least one of the triazoles with mutations of TR34/L98H or TR46/Y121F/T289A in
      CYP51A gene. The echinocandins were highly potent to the tested Aspergillus
      isolates. CONCLUSION: The existence of triazole resistance among A. fumigatus
      isolates in Taiwan and Mainland China indicates the need for continuous
      monitoring from now on.

PMID- 29844004
TI  - Transcatheter Device Closure of Aortopulmonary Window. Is There a Need for an
      Alternative Strategy to Surgery?

PMID- 29844005
TI  - Tako-tsubo Cardiomyopathy Complicated With Cardiac Tamponade and Cardiogenic
      Shock.

PMID- 29844006
TI  - Phenotype-modifying Factors in Hypertrophic Cardiomyopathy.

PMID- 29844007
TI  - Case Report: Chemotherapy in Conjunction With Blood-Brain Barrier Disruption for
      a Patient With Germ Cell Tumor With Multiple Brain Metastases.

PMID- 29844008
TI  - Heterogeneity of Second-Line Treatment for Patients With Multiple Myeloma in the
      Connect MM Registry (2010-2016).
AB  - BACKGROUND: The treatment landscape for multiple myeloma (MM) has undergone
      recent changes with the regulatory approval of several new therapies indicated
      for second- and later-line disease. Using data from Connect MM, the largest
      multisite, primarily community-based, prospective, observational registry of MM
      patients in the United States, selection of second-line treatments was evaluated
      during a 5-year period from 2010 to 2016. PATIENTS AND METHODS: Eligible patients
      were aged >= 18 years, had newly diagnosed MM <= 2 months before study entry, and
      were followed for up to 8 years. Patients who received >= 2 lines of therapy were
      analyzed. "Tepee" plots of stacked area graphs differentiated treatments by color
      to allow visualization of second-line treatment trends in MM patients. RESULTS:
      As of February 2017, 855 of 2897 treated patients had progressed to second-line
      treatment. Treatment selection was heterogeneous; shifting patterns of treatment
      choices coincided with the approval status of newer agents. The most common
      treatment regimens in the early part of the decade were lenalidomide and/or
      bortezomib, with or without dexamethasone, with increasing use of newer agents
      (carfilzomib, pomalidomide, daratumumab, and elotuzumab) and triplet combinations
      over time. The influence of the baseline patient characteristics of age, history
      of diabetes, peripheral neuropathy, and renal function on treatment choice was
      also examined. CONCLUSION: These findings indicate that community physicians are
      current in their MM management practices, with uptake of new drugs and
      acquaintance with results of randomized clinical trials using combinations almost
      concurrent with their regulatory approval and publication.

PMID- 29844009
TI  - Workflow and efficiency in MRI-based high-dose-rate brachytherapy for cervical
      cancer in a high-volume brachytherapy center.
AB  - PURPOSE: We report the clinical workflow and time required for MRI-based image
      guided brachytherapy (MR-IGBT) of cervical cancer patients in a high-volume
      brachytherapy center with 10 years of experiences to provide a practical
      guideline for implementing MR-IGBT into clinical use. METHODS AND MATERIALS: We
      recorded the time and workflow of each procedure step within the 40 consecutive
      ring and tandem applicator fractions of MR-IGBT by our multidisciplinary team. We
      divided the entire procedure into four sections based on where the procedure was
      performed: (1) applicator insertion under sedation, (2) MR imaging, (3) planning,
      and (4) treatment delivery. In addition, we compared the current procedure time
      to the initial procedure time when first implementing MR-IGBT in 2007-2008 via a
      retrospective review. RESULTS: Mean total procedure time was 149.3 min (SD 17.9,
      ranges 112-178). The multidisciplinary team included an anesthesia team,
      radiologist, radiation oncologist, nurses, radiation therapists, MRI technicians,
      dosimetrists, and physicists. The mean procedure time and ranges for each section
      (min) were as follows: (1) 56.2 (28.0-103.0), (2) 31.0 (19.0-70.0), (3) 44.3
      (21.0-104.0), and (4) 17.8 (9.0-34.0). Under current setting, the combined mean
      procedure time for MR imaging and planning was 63.2 min. In comparison, the same
      procedure took 137.7 min in 2007-2008 period, which was significantly longer than
      the current workflow (p < 0.001). CONCLUSIONS: A skilled and dedicated
      multidisciplinary team is required for an efficient clinical workflow and
      delivery of MR-IGBT. Over the years, we have improved efficiency with clinical
      experience and continuous efforts in staff education.

PMID- 29844010
TI  - Possible Sources of Bias in Primary Care Electronic Health Record Data Use and
      Reuse.
AB  - BACKGROUND: Enormous amounts of data are recorded routinely in health care as
      part of the care process, primarily for managing individual patient care. There
      are significant opportunities to use these data for other purposes, many of which
      would contribute to establishing a learning health system. This is particularly
      true for data recorded in primary care settings, as in many countries, these are
      the first place patients turn to for most health problems. OBJECTIVE: In this
      paper, we discuss whether data that are recorded routinely as part of the health
      care process in primary care are actually fit to use for other purposes such as
      research and quality of health care indicators, how the original purpose may
      affect the extent to which the data are fit for another purpose, and the
      mechanisms behind these effects. In doing so, we want to identify possible
      sources of bias that are relevant for the use and reuse of these type of data.
      METHODS: This paper is based on the authors' experience as users of electronic
      health records data, as general practitioners, health informatics experts, and
      health services researchers. It is a product of the discussions they had during
      the Translational Research and Patient Safety in Europe (TRANSFoRm) project,
      which was funded by the European Commission and sought to develop, pilot, and
      evaluate a core information architecture for the learning health system in
      Europe, based on primary care electronic health records. RESULTS: We first
      describe the different stages in the processing of electronic health record data,
      as well as the different purposes for which these data are used. Given the
      different data processing steps and purposes, we then discuss the possible
      mechanisms for each individual data processing step that can generate biased
      outcomes. We identified 13 possible sources of bias. Four of them are related to
      the organization of a health care system, whereas some are of a more technical
      nature. CONCLUSIONS: There are a substantial number of possible sources of bias;
      very little is known about the size and direction of their impact. However,
      anyone that uses or reuses data that were recorded as part of the health care
      process (such as researchers and clinicians) should be aware of the associated
      data collection process and environmental influences that can affect the quality
      of the data. Our stepwise, actor- and purpose-oriented approach may help to
      identify these possible sources of bias. Unless data quality issues are better
      understood and unless adequate controls are embedded throughout the data
      lifecycle, data-driven health care will not live up to its expectations. We need
      a data quality research agenda to devise the appropriate instruments needed to
      assess the magnitude of each of the possible sources of bias, and then start
      measuring their impact. The possible sources of bias described in this paper
      serve as a starting point for this research agenda.

PMID- 29844011
TI  - USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through
      a PU.1-dependent mechanism.
AB  - Ras mutations are commonly observed in juvenile myelomonocytic leukemia (JMML)
      and chronic myelomonocytic leukemia (CMML). JMML and CMML transform into acute
      myeloid leukemia (AML) in about 10% and 50% of patients, respectively. However,
      how additional events cooperate with Ras to promote this transformation are
      largely unknown. We show that absence of the ubiquitin-specific peptidase 22
      (USP22), a component of the Spt-Ada-GCN5-acetyltransferase chromatin-remodeling
      complex that is linked to cancer progression, unexpectedly promotes AML
      transformation in mice expressing oncogenic KrasG12D/+ USP22 deficiency in
      KrasG12D/+ mice resulted in shorter survival compared with control mice. This was
      due to a block in myeloid cell differentiation leading to the generation of AML.
      This effect was cell autonomous because mice transplanted with USP22-deficient
      KrasG12D/+ cells developed an aggressive disease and died rapidly. The
      transcriptome profile of USP22-deficient KrasG12D/+ progenitors resembled
      leukemic stem cells and was highly correlated with genes associated with poor
      prognosis in AML. We show that USP22 functions as a PU.1 deubiquitylase by
      positively regulating its protein stability and promoting the expression of PU.1
      target genes. Reconstitution of PU.1 overexpression in USP22-deficient KrasG12D/+
      progenitors rescued their differentiation. Our findings uncovered an unexpected
      role for USP22 in Ras-induced leukemogenesis and provide further insights into
      the function of USP22 in carcinogenesis.

PMID- 29844012
TI  - Transhumanism: five minutes with . . . Mark O'Connell.

PMID- 29844015
TI  - Margaret McCartney: We must look at the whole impact of revalidation.

PMID- 29844014
TI  - An allosteric propofol-binding site in kinesin disrupts kinesin-mediated
      processive movement on microtubules.
AB  - Microtubule-based molecular motors mediate transport of intracellular cargo to
      subdomains in neurons. Previous evidence has suggested that the anesthetic
      propofol decreases the average run-length potential of the major anterograde
      transporters kinesin-1 and kinesin-2 without altering their velocity. This effect
      on kinesin has not been observed with other inhibitors, stimulating considerable
      interest in the underlying mechanism. Here, we used a photoactive derivative of
      propofol, meta-azipropofol (AziPm), to search for potential propofol-binding
      sites in kinesin. Single-molecule motility assays confirmed that AziPm and
      propofol similarly inhibit kinesin-1 and kinesin-2. We then applied AziPm in
      semiquantitative radiolabeling and MS microsequencing assays to identify propofol
      binding sites within microtubule-kinesin complexes. The radiolabeling experiments
      suggested preferential AziPm binding to the ATP-bound microtubule-kinesin
      complex. The photolabeled residues were contained within the kinesin motor domain
      rather than at the motor domain-beta-tubulin interface. No residues within the P
      loop of kinesin were photolabeled, indicating an inhibitory mechanism that does
      not directly affect ATPase activity and has an effect on run length without
      changing velocity. Our results also indicated that when the kinesin motor
      interacts with the microtubule during its processive run, a site forms in kinesin
      to which propofol can then bind and allosterically disrupt the kinesin
      microtubule interaction, resulting in kinesin detachment and run termination. The
      discovery of the propofol-binding allosteric site in kinesin may improve our
      understanding of the strict coordination of the motor heads during the processive
      run. We hypothesize that propofol's potent effect on intracellular transport
      contributes to various components of its anesthetic action.

PMID- 29844013
TI  - Alcohol intake in relation to non-fatal and fatal coronary heart disease and
      stroke: EPIC-CVD case-cohort study.
AB  - OBJECTIVE: To investigate the association between alcohol consumption (at
      baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD)
      and stroke. DESIGN: Multicentre case-cohort study. SETTING: A study of
      cardiovascular disease (CVD) determinants within the European Prospective
      Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European
      countries. PARTICIPANTS: 32 549 participants without baseline CVD, comprised of
      incident CVD cases and a subcohort for comparison. MAIN OUTCOME MEASURES: Non
      fatal and fatal CHD and stroke (including ischaemic and haemorrhagic stroke).
      RESULTS: There were 9307 non-fatal CHD events, 1699 fatal CHD, 5855 non-fatal
      stroke, and 733 fatal stroke. Baseline alcohol intake was inversely associated
      with non-fatal CHD, with a hazard ratio of 0.94 (95% confidence interval 0.92 to
      0.96) per 12 g/day higher intake. There was a J shaped association between
      baseline alcohol intake and risk of fatal CHD. The hazard ratios were 0.83 (0.70
      to 0.98), 0.65 (0.53 to 0.81), and 0.82 (0.65 to 1.03) for categories 5.0-14.9
      g/day, 15.0-29.9 g/day, and 30.0-59.9 g/day of total alcohol intake,
      respectively, compared with 0.1-4.9 g/day. In contrast, hazard ratios for non
      fatal and fatal stroke risk were 1.04 (1.02 to 1.07), and 1.05 (0.98 to 1.13) per
      12 g/day increase in baseline alcohol intake, respectively, including broadly
      similar findings for ischaemic and haemorrhagic stroke. Associations with
      cardiovascular outcomes were broadly similar with average lifetime alcohol
      consumption as for baseline alcohol intake, and across the eight countries
      studied. There was no strong evidence for interactions of alcohol consumption
      with smoking status on the risk of CVD events. CONCLUSIONS: Alcohol intake was
      inversely associated with non-fatal CHD risk but positively associated with the
      risk of different stroke subtypes. This highlights the opposing associations of
      alcohol intake with different CVD types and strengthens the evidence for policies
      to reduce alcohol consumption.

PMID- 29844016
TI  - The trimeric coiled-coil HSBP1 protein promotes WASH complex assembly at
      centrosomes.
AB  - The Arp2/3 complex generates branched actin networks that exert pushing forces
      onto different cellular membranes. WASH complexes activate Arp2/3 complexes at
      the surface of endosomes and thereby fission transport intermediates containing
      endocytosed receptors, such as alpha5beta1 integrins. How WASH complexes are
      assembled in the cell is unknown. Here, we identify the small coiled-coil protein
      HSBP1 as a factor that specifically promotes the assembly of a ternary complex
      composed of CCDC53, WASH, and FAM21 by dissociating the CCDC53 homotrimeric
      precursor. HSBP1 operates at the centrosome, which concentrates the building
      blocks. HSBP1 depletion in human cancer cell lines and in Dictyostelium amoebae
      phenocopies WASH depletion, suggesting a critical role of the ternary WASH
      complex for WASH functions. HSBP1 is required for the development of focal
      adhesions and of cell polarity. These defects impair the migration and invasion
      of tumor cells. Overexpression of HSBP1 in breast tumors is associated with
      increased levels of WASH complexes and with poor prognosis for patients.

PMID- 29844018
TI  - Review of L10 000 gender pay gap in medicine is launched.

PMID- 29844017
TI  - Quantitative Morphological Variation in the Developing Drosophila Wing.
AB  - Quantitative genetic variation in morphology is pervasive in all species and is
      the basis for the evolution of differences among species. The measurement of
      morphological form in adults is now beginning to be combined with comparable
      measurements of form during development. Here we compare the shape of the
      developing wing to its adult form in a holometabolous insect, Drosophila
      melanogaster We used protein expression patterns to measure shape in the
      developing precursors of the final adult wing. Three developmental stages were
      studied: late larval third instar, post-pupariation and in the adult fly. We
      studied wild-type animals in addition to mutants of two genes (shf and ds) that
      have known effects on adult wing shape and size. Despite experimental noise
      related to the difficulty of comparing developing structures, we found consistent
      differences in wing shape and size at each developmental stage between genotypes.
      Quantitative comparisons of variation arising at different developmental stages
      with the variation in the final structure enable us to determine when variation
      arises, and to generate hypotheses about the causes of that variation. In
      addition we provide linear rules allowing us to link wing morphology in the
      larva, with wing morphology in the pupa. Our approach provides a framework to
      analyze quantitative morphological variation in the developing fly wing. This
      framework should help to characterize the natural variation of the larval and
      pupal wing shape, and to measure the contribution of the processes occurring
      during these developmental stages to the natural variation in adult wing
      morphology.

PMID- 29844020
TI  - David Oliver: "Ghost wards" and rota gaps show the need for official safe
      staffing levels.

PMID- 29844021
TI  - Correction to: 2016 ACC/AHA Clinical Performance and Quality Measures for Adults
      With Atrial Fibrillation or Atrial Flutter: A Report of the American College of
      Cardiology/American Heart Association Task Force on Performance Measures.

PMID- 29844019
TI  - Bone remodeling induced by mechanical forces is regulated by miRNAs.
AB  - The relationship between mechanical force and alveolar bone remodeling is an
      important issue in orthodontics because tooth movement is dependent on the
      response of bone tissue to the mechanical force induced by the appliances used.
      Mechanical cyclical stretch (MCS), fluid shear stress (FSS), compression, and
      microgravity play different roles in the cell differentiation and proliferation
      involved in bone remodeling. However, the underlying mechanisms are unclear,
      particularly the molecular pathways regulated by non-coding RNAs (ncRNAs) that
      play essential roles in bone remodeling. Amongst the various ncRNAs, miRNAs act
      as post-transcriptional regulators that inhibit the expression of their target
      genes. miRNAs are considered key regulators of many biologic processes including
      bone remodeling. Here, we review the role of miRNAs in mechanical force-induced
      bone metabolism.

PMID- 29844023
TI  - Shifting the Paradigm: The Quiet Revolution of Pediatric Procedural Sedation
      Practice.

PMID- 29844022
TI  - A Central Extended Amygdala Circuit That Modulates Anxiety.
AB  - Both the amygdala and the bed nucleus of the stria terminalis (BNST) have been
      implicated in maladaptive anxiety characteristics of anxiety disorders. However,
      the underlying circuit and cellular mechanisms have remained elusive. Here we
      show that mice with Erbb4 gene deficiency in somatostatin-expressing (SOM+)
      neurons exhibit heightened anxiety as measured in the elevated plus maze test and
      the open field test, two assays commonly used to assess anxiety-related behaviors
      in rodents. Using a combination of electrophysiological, molecular, genetic, and
      pharmacological techniques, we demonstrate that the abnormal anxiety in the
      mutant mice is caused by enhanced excitatory synaptic inputs onto SOM+ neurons in
      the central amygdala (CeA), and the resulting reduction in inhibition onto
      downstream SOM+ neurons in the BNST. Notably, our results indicate that an
      increase in dynorphin signaling in SOM+ CeA neurons mediates the paradoxical
      reduction in inhibition onto SOM+ BNST neurons, and that the consequent enhanced
      activity of SOM+ BNST neurons is both necessary for and sufficient to drive the
      elevated anxiety. Finally, we show that the elevated anxiety and the associated
      synaptic dysfunctions and increased dynorphin signaling in the CeA-BNST circuit
      of the Erbb4 mutant mice can be recapitulated by stress in wild-type mice.
      Together, our results unravel previously unknown circuit and cellular processes
      in the central extended amygdala that can cause maladaptive anxiety.SIGNIFICANCE
      STATEMENT The central extended amygdala has been implicated in anxiety-related
      behaviors, but the underlying mechanisms are unclear. Here we found that
      somatostatin-expressing neurons in the central amygdala (CeA) controls anxiety
      through modulation of the stria terminalis, a process that is mediated by an
      increase in dynorphin signaling in the CeA. Our results reveal circuit and
      cellular dysfunctions that may account for maladaptive anxiety.

PMID- 29844025
TI  - Sixty seconds on . . . digitalisation of pharma.

PMID- 29844024
TI  - Apnea in Preterm and Term Infants After Deep Sedation and General Anesthesia.
AB  - OBJECTIVES: Determine the incidence of apnea in preterm and term infants after
      deep sedation (DS) compared with general anesthesia (GA). METHODS: A
      retrospective chart review was performed on infants who underwent elective DS or
      GA from January 2008 to December 2013, were <60 weeks postmenstrual age if
      preterm or <50 weeks postmenstrual age if term, and were monitored for apnea as
      inpatients after DS or GA. Gestational age, postmenstrual age, chronologic age,
      anesthetic and sedative medications, procedure indication, and postsedation
      events were collected. RESULTS: There were 61 DS encounters (24 preterm and 37
      term) and 175 GA encounters (120 preterm and 55 term) that met inclusion
      criteria. No recorded apneic events in either preterm or term infants were
      recorded after DS. After GA, 1.7% of infants had apneic events (2.5% preterm and
      0 term; P = .57 versus DS). All events occurred within 2 hours of monitoring in
      recovery. CONCLUSIONS: None of the infants had apnea after DS. Rates from the
      literature would suggest that 2 to 6 of the preterm DS subjects should have
      experienced postsedation apnea. Sampled GA subjects had a rate of 2.5% in preterm
      infants exhibiting apnea after GA. Although the post-DS apnea rate is lower than
      what has been previously published, the small sample size and limitations of a
      retrospective design prevent us from directing a change in postsedation
      monitoring recommendations. However, we do support the need for prospective
      studies with strict monitoring criteria to reveal the true risk of post-DS apnea.

PMID- 29844026
TI  - Inherited DNA methylation primes the establishment of accessible chromatin during
      genome activation.
AB  - For animals, epigenetic modifications can be globally or partially inherited from
      gametes after fertilization, and such information is required for proper
      transcriptional regulation, especially during the process of zygotic genome
      activation (ZGA). However, the mechanism underlying how the inherited epigenetic
      signatures affect transcriptional regulation during ZGA remains poorly
      understood. Here, we performed genome-wide profiling of chromatin accessibility
      during zebrafish ZGA, which is closely related to zygotic transcriptional
      regulation. We observed a clear trend toward a gradual increase in accessible
      chromatin during ZGA. Furthermore, accessible chromatin at the promoters
      displayed a sequential priority of emergence, and the locations of the accessible
      chromatin were precisely primed by the enrichment of unmethylated CpGs that were
      fully inherited from gametes. On the other hand, distal regions with high
      methylation levels that were inherited from the sperm facilitated the binding of
      DNA methylation-preferred transcription factors, such as Pou5f3 and Nanog, which
      contributed to the establishment of accessible chromatin at these loci. Our
      results demonstrate a model whereby inherited DNA methylation signatures from
      gametes prime the establishment of accessible chromatin during zebrafish ZGA
      through two distinct mechanisms.

PMID- 29844027
TI  - Low Serum Calcium and Magnesium Levels and Rupture of Intracranial Aneurysms.
AB  - BACKGROUND AND PURPOSE: Both low serum calcium and magnesium levels have been
      associated with the extent of bleeding in patients with intracerebral hemorrhage,
      suggesting hypocalcemia- and hypomagnesemia-induced coagulopathy as a possible
      underlying mechanism. We hypothesized that serum albumin-corrected total calcium
      and magnesium levels are associated with ruptured intracranial aneurysms.
      METHODS: The medical records of 4701 patients, including 1201 prospective
      patients, diagnosed at the Brigham and Women's Hospital and Massachusetts General
      Hospital between 1990 and 2016 were reviewed and analyzed. One thousand two
      hundred seventy-five patients had available serum calcium, magnesium, and albumin
      values within 1 day of diagnosis. Individuals were divided into cases with
      ruptured aneurysms and controls with unruptured aneurysms. Univariable and
      multivariable logistic regression analyses were performed to determine the
      association between serum albumin-corrected total calcium and magnesium levels
      and ruptured aneurysms. RESULTS: In multivariable analysis, both albumin
      corrected calcium (odds ratio, 0.33; 95% confidence interval, 0.27-0.40) and
      magnesium (odds ratio, 0.40; 95% confidence interval, 0.28-0.55) were
      significantly and inversely associated with ruptured intracranial aneurysms.
      CONCLUSIONS: In this large case-control study, hypocalcemia and hypomagnesemia at
      diagnosis were significantly associated with ruptured aneurysms. Impaired
      hemostasis caused by hypocalcemia and hypomagnesemia may explain this
      association.

PMID- 29844028
TI  - Taurine Reduces tPA (Tissue-Type Plasminogen Activator)-Induced Hemorrhage and
      Microvascular Thrombosis After Embolic Stroke in Rat.
AB  - BACKGROUND AND PURPOSE: Taurine (2-aminoethansulfolic amino acid) exerts
      neuroprotective actions in experimental stroke. Here, we investigated the effect
      of taurine in combination with delayed tPA (tissue-type plasminogen activator) on
      embolic stroke. METHODS: Rats subjected to embolic middle cerebral artery
      occlusion were treated with taurine (50 mg/kg) at 4 hours in combination with tPA
      (10 mg/kg) at 6 hours. Control groups consisted of ischemic rats treated with
      either taurine (50 mg/kg) or saline at 4 hours or tPA (10 mg/kg) alone at 2 or 6
      hours after middle cerebral artery occlusion. RESULTS: We found that combination
      treatment with taurine and tPA robustly reduced infarct volume and neurological
      deficits 3 days after stroke, whereas treatment with taurine alone had a less
      significant protective effect. tPA alone at 6 hours had no effects on infarct
      volume but instead induced intracerebral hemorrhage. The combination treatment
      with taurine prevented tPA-associated hemorrhage and reduced intravascular
      deposition of fibrin/fibrinogen and platelets in downstream microvessels and
      hence improved microvascular patency. These protective effects are associated
      with profound inhibition of CD147 (cluster of differentiation 147)-dependent MMP
      9 (matrix metalloproteinase-9) pathway in ischemic brain endothelium by taurine.
      Notably, targeted inhibition of CD147 by intracerebroventricular injection of the
      rat CD147 siRNA profoundly inhibited ischemia-induced and tPA-enhanced MMP-9
      activity in ischemic brain endothelium and blocked tPA-induced cerebral
      hemorrhage. Finally, the combination treatment with taurine and tPA improved long
      term outcome at least 45 days after stroke compared with saline-treated group.
      CONCLUSIONS: Our results suggest that taurine in combination with tPA may be a
      clinically feasible approach toward future attempts at combination stroke
      therapy.

PMID- 29844029
TI  - Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated
      Microglial Migration and Proliferation.
AB  - BACKGROUND AND PURPOSE: Cerebral microbleeds are linked to cognitive decline, but
      it remains unclear how they impair neuronal function. Infarction is not typically
      observed near microbleeds, suggesting more subtle mechanisms, such as
      inflammation, may play a role. Because of their small size and largely
      asymptomatic nature, real-time detection and study of spontaneous cerebral
      microbleeds in humans and animal models are difficult. METHODS: We used in vivo 2
      photon microscopy through a chronic cranial window in adult mice to follow the
      inflammatory response after a cortical microhemorrhage of ~100 um diameter,
      induced by rupturing a targeted cortical arteriole with a laser. RESULTS: The
      inflammatory response included the invasion of blood-borne leukocytes, the
      migration and proliferation of brain-resident microglia, and the activation of
      astrocytes. Nearly all inflammatory cells responding to the microhemorrhage were
      brain-resident microglia, but a small number of CX3CR1+ and CCR2+ macrophages,
      ultimately originating from the invasion of blood-borne monocytes, were also
      found near the lesion. We found a coordinated pattern of microglia migration and
      proliferation, where microglia within 200 um of the microhemorrhage migrated
      toward the lesion over hours to days. In contrast, microglia proliferation was
      not observed until ~40 hours after the lesion and occurred primarily in a shell
      shaped region where the migration of microglia decreased their local density.
      These data suggest that local microglia density changes may trigger
      proliferation. Astrocytes activated in a similar region as microglia but delayed
      by a few days. By 2 weeks, this inflammatory response had largely resolved.
      CONCLUSIONS: Although microhemorrhages are small in size, the brain responds to a
      single bleed with an inflammatory response that involves brain-resident and blood
      derived cells, persists for weeks, and may impact the adjacent brain
      microenvironment.

PMID- 29844030
TI  - Continuation or Discontinuation of Anticoagulation in the Early Phase After Acute
      Ischemic Stroke.
AB  - BACKGROUND AND PURPOSE: There is no consensus on whether anticoagulation should
      be continued or temporarily stopped in patients suffering acute ischemic stroke
      while using anticoagulation. We assessed treatment variations and outcomes in
      these patients. METHODS: Post hoc analysis of PASS (Preventive Antibiotics in
      Stroke Study). We included patients with acute ischemic stroke who used
      anticoagulation at admission. We compared clinical outcomes, thrombotic, and
      major bleeding events at 3 months. RESULTS: Nine percent (192/2101) of the
      patients with acute ischemic stroke used anticoagulation at admission (186
      vitamin K antagonists). Anticoagulation was discontinued in 35/192 (18%)
      patients. These patients had higher National Institutes of Health Stroke Scale
      scores than patients in whom anticoagulation was continued (median, 13 versus 4;
      P<0.001). Thrombotic events occurred more frequently in patients in whom
      anticoagulation was discontinued (11% versus 3%; P=0.038). There were no major
      bleeding events in either group. Mortality and clinical outcomes at 90 days were
      worse in patients in whom anticoagulation was discontinued (mortality, 31% versus
      15%; P=0.019 and modified Rankin Scale score of 0-2, 20% versus 55%; P<0.001).
      After adjustment for potential confounders, there were no statistically
      significant differences between groups. CONCLUSIONS: In our study, clinicians
      tended to continue anticoagulation in patients with acute ischemic stroke.
      Discontinuation was associated with an increased risk of thrombotic events and
      worse clinical outcome. Risk of major bleeding was not increased in patients in
      whom anticoagulation was continued. CLINICAL TRIAL REGISTRATION: URL:
      https://www.controlled-trials.com. Unique identifier: ISRCTN66140176.

PMID- 29844031
TI  - Impact of Transcranial Doppler Ultrasound on Logistics and Outcomes in Stroke
      Thrombolysis: Results From the SITS-ISTR.
AB  - BACKGROUND AND PURPOSE: Diagnostic transcranial Doppler ultrasound (TCD) is
      commonly used in patients with acute stroke before or during treatment with
      intravenous thrombolysis (IVT). We aimed to assess how much TCD delays IVT
      initiation and whether TCD influences outcomes. METHODS: We analyzed data from
      the SITS-ISTR (Safe Implementation of Thrombolysis in Stroke-International Stroke
      Thrombolysis Register) collected from December 2002 to December 2011. Outcomes
      were door-to-needle time, symptomatic intracerebral hemorrhage, functional
      outcome per the modified Rankin Scale, and mortality at 3 months. RESULTS: In
      hospitals performing any TCD pre-IVT, 1701 of 11 265 patients (15%) had TCD
      before IVT initiation. Door-to-needle time was higher in patients with pre-IVT
      TCD (74 versus 60 minutes; P<0.001). At hospitals performing any TCD during IVT
      infusion, of 9044 patients with IVT, 747 were examined with TCD during IVT. No
      treatment delay was seen with TCD during IVT. After multivariate adjustment, TCD
      during IVT was independently associated with modestly increased excellent
      functional outcome (modified Rankin Scale, 0-1; adjusted odds ratio, 1.28; 95%
      confidence interval, 1.06-1.55; P=0.012) and lower mortality (adjusted odds
      ratio, 0.73; 95% confidence interval, 0.55-0.95; P=0.022). CONCLUSIONS: We
      recommend that TCD, if performed, should be done during IVT infusion, to avoid
      treatment delay. The association of hyperacute TCD with beneficial outcomes
      suggests potential impact on patient management, which warrants further study.

PMID- 29844032
TI  - Surface display of small affinity proteins on Synechocystis sp. PCC 6803 mediated
      by fusion to the major type IV pilin PilA1.
AB  - Functional surface display of small affinity proteins, namely Affibodies (6.5
      kDa), was evaluated for the model cyanobacterium Synechocystis sp. PCC 6803,
      through anchoring to native surface structures. These structures included
      confirmed or putative subunits of the type IV pili, the S-layer protein, and the
      heterologous Escherichia coli autotransporter antigen 43 system. The most stable
      display system was determined to be through C-terminal fusion to PilA1, the major
      type IV pili subunit in Synechocystis, in a strain unable to retract these pili
      (DeltapilT1). Type IV pili synthesis was upheld, albeit reduced, when fusion
      proteins were incorporated. However, pili-mediated functions such as motility and
      transformational competency were negatively affected. Display of Affibodies on
      Synechocystis and the complementary anti-idiotypic Affibodies on E. coli or
      Staphylococcus carnosus was able to mediate interspecies cell-cell binding by
      Affibody complex formation. The same strategy was however not able to drive cell
      cell binding and aggregation of Synechocystis-only mixtures. Successful Affibody
      tagging of the putative minor pilin PilA4 showed that it locates to the type IV
      pili in Synechocystis, and that its extracellular availability depends on PilA1.
      In addition, Affibody-tagging of the S-layer protein indicated that the domains
      responsible for anchoring and secretion of this protein are located at the N- and
      C-terminus, respectively. This study can serve as a basis for future surface
      display of proteins on Synechocystis for biotechnological applications.Importance
      Cyanobacteria are gaining interest for their potential as autotrophic cell
      factories. Development of efficient surface display strategies could improve
      their suitability for large-scale applications by providing options for designed
      microbial consortia, cell immobilization, and biomass harvesting. Here, surface
      display of small affinity proteins was realized by fusing them to the major
      subunit of the native type IV pili in Synechocystis sp. PCC 6803. Display of
      complementary affinity proteins allowed specific cell-cell binding between
      Synechocystis and Escherichia coli or Staphylococcus carnosus Additionally,
      successful tagging of the putative pilin PilA4, helped determine its localization
      to the type IV pili. Analogous tagging of the S-layer protein shed light on the
      regions involved in its secretion and surface anchoring.

PMID- 29844034
TI  - Benign acute myositis in an adult patient.
AB  - The benign acute childhood myositis presents as a marked and painful oedema of
      leg muscles in the days following a viral illness. This disease is often
      considered as occurring only in children. We report the case of a 32-year-old
      patient who presented with severe pain and oedema of both legs associated with
      motor deficit of lower extremities. He suffered from a grippal syndrome for 4
      days. Creatine kinase blood level rose up to 39 394 IU/L (n<200) and a muscle
      biopsy of left tibialis anterior found necrosisand regeneration of myocytes
      without inflammatory infiltrates. All clinical and paraclinical abnormalities
      spontaneously disappeared in a few days. This case illustrates that a disorder
      similar to benign acute childhood myositis may occur in adult patients. Muscle
      biopsy might be avoided in typical cases because of the favourable evolution.

PMID- 29844033
TI  - Resistance to UV Irradiation Caused by Inactivation of nurA and herA Genes in
      Thermus thermophilus.
AB  - NurA and HerA are thought to be essential proteins for DNA end resection in
      archaeal homologous recombination systems. Thermus thermophilus, an extremely
      thermophilic eubacterium, has proteins that exhibit significant sequence
      similarity to archaeal NurA and HerA. To unveil the cellular function of NurA and
      HerA in T. thermophilus, we performed phenotypic analysis of disruptant mutants
      of nurA and herA with or without DNA-damaging agents. The nurA and herA genes
      were not essential for survival, and their deletion had no effect on cell growth
      and genome integrity. Unexpectedly, these disruptants of T. thermophilus showed
      increased resistance to UV irradiation and mitomycin C treatment. Further, these
      disruptants and the wild type displayed no difference in sensitivity to oxidative
      stress and a DNA replication inhibitor. T. thermophilus NurA had nuclease
      activity, and HerA had ATPase. The overexpression of loss-of-function mutants of
      nurA and herA in the respective disruptants showed no complementation, suggesting
      their enzymatic activities were involved in the UV sensitivity. In addition, T.
      thermophilus NurA and HerA interacted with each other in vitro and in vivo,
      forming a complex with 2:6 stoichiometry. These results suggest that the NurA
      HerA complex has an architecture similar to that of archaeal counterparts but
      that it impairs, rather than promotes, the repair of photoproducts and DNA cross
      links in T. thermophilus cells. This cellular function is distinctly different
      from that of archaeal NurA and HerA.IMPORTANCE Many nucleases and helicases are
      engaged in homologous recombination-mediated DNA repair. Previous in vitro
      analyses in archaea indicated that NurA and HerA are the recombination-related
      nuclease and helicase. However, their cellular function had not been fully
      understood, especially in bacterial cells. In this study, we performed in vivo
      analyses to address the cellular function of nurA and herA in an extremely
      thermophilic bacterium, Thermus thermophilus As a result, T. thermophilus NurA
      and HerA exhibited an interfering effect on the repair of several instances of
      DNA damage in the cell, which is in contrast to the results in archaea. This
      finding will facilitate our understanding of the diverse cellular functions of
      the recombination-related nucleases and helicases.

PMID- 29844035
TI  - Keratinising squamous cell metaplasia: when is it safe to stop looking?
AB  - Keratinising squamous cell metaplasia (KSCM) is an uncommon diagnosis in the
      West. Patients typically present with lower urinary tract symptoms: haematuria
      (visible and non-visible), dysuria, urgency and frequency. Investigation is rigid
      cystoscopy. Abnormal bladder wall tissue should be resected and biopsies sent for
      histopathology to confirm KSCM. This is a preneoplastic condition with strong
      associations with squamous cell carcinoma. Due to a significant lag time, annual
      cystoscopy with multiple biopsies is recommended.

PMID- 29844036
TI  - Thoracic oesophageal cancer as a cause of stridor: a literature review.
AB  - An 83-year-old woman, with a background of treated squamous cell oesophageal
      cancer, presented with a 3-week history of stridor. Of note, the patient had no
      risk factors for oesophageal cancer other than age. Clinical examination was
      unremarkable apart from stridor. Laboratory investigations, including arterial
      blood gas on room air, were unremarkable. Radiological examination revealed a
      4.5*3.5*3.6 cm mass involving the posterior trachea and invading the tracheal
      orifice. Oesophagogastroduodenoscopy and rigid bronchoscopy confirmed an
      extensive tumour arising from the lower oesophagus and invading the trachea,
      causing 90% airway obstruction for a 6 mm length ending 1.5 cm above the carina.
      Biopsy revealed a poorly differentiated carcinoma with foci of squamous cell
      carcinoma. Unfortunately, the patient passed away 2 months after palliative
      tracheal stent placement.

PMID- 29844037
TI  - Acute non-cardiogenic pulmonary oedema due to contralateral pulmonary re
      expansion after thoracentesis: an uncommon complication.

PMID- 29844038
TI  - Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine beta
      Lactamases.
AB  - CTX-M is the most prevalent family of extended-spectrum beta-lactamases. We
      recently developed a tetrazole-derived noncovalent inhibitor of CTX-M-9. Here, we
      present the biochemical and microbiological activity of this inhibitor across a
      representative panel of serine beta-lactamases and Gram-negative bacteria. The
      compound displayed significant activity against all major subgroups of CTX-M,
      including CTX-M-15, while it exhibited some low-level inhibition of other serine
      beta-lactamases. Complex crystal structures with the CTX-M-14 S237A mutant and
      CTX-M-27 illustrate the binding contribution of specific active-site residues on
      the beta3 strand. In vitro pharmacokinetic studies revealed drug-like properties
      and positive prospects for further optimization. These studies suggest that
      tetrazole-based compounds can provide novel chemotypes for future serine beta
      lactamase inhibitor discovery.

PMID- 29844039
TI  - Nephrotoxicity Associated with Intravenous Polymyxin B Once- versus Twice-Daily
      Dosing Regimen.
AB  - Nephrotoxicity is a known adverse effect of polymyxin B (PMB). Animal data
      suggest that once-daily dosing may reduce the rate and delay the onset of acute
      kidney injury (AKI). In a multicenter retrospective study, we evaluated adult
      patients with a creatinine clearance (CrCl) of >=30 ml/min who received >=48 h of
      PMB therapy. The primary endpoint was the difference in rate of AKI comparing
      once- and twice-daily PMB dosing. The secondary endpoints included the time to
      AKI and the recovery of renal function. Of 273 eligible patients, 100 from each
      group were matched on the basis of propensity scores. In the matched groups,
      nephrotoxicity, defined according to risk, injury, failure, loss, and end-stage
      renal disease (RIFLE) criteria, was more frequent with once- than with twice
      daily dosing (47% versus 17%, respectively; P = 0.0005). After adjusting for
      residual differences by multivariate conditional logistic regression, once-daily
      dosing was more likely to result in nephrotoxicity (adjusted odds ratio, 2.5; 95%
      confidence interval [CI], 1.413 to 4.541; P = 0.002). Among 64 patients who
      developed AKI, the median onsets were similar between the groups (7 days with
      once versus 6 days with twice-daily dosing, P = 0.095). Of 37 patients who had
      their serum creatinine evaluated subsequently, 29/37 (78%) had recovery of renal
      function. No patient required renal replacement therapy. Our findings suggest
      that AKI is significantly more common with PMB once daily than with twice-daily
      dosing with no difference in time to AKI. A prospective randomized study is
      warranted to validate these results.

PMID- 29844040
TI  - Fragments of the Nonlytic Proline-Rich Antimicrobial Peptide Bac5 Kill
      Escherichia coli Cells by Inhibiting Protein Synthesis.
AB  - Unlike most antimicrobial peptides (AMPs), the main mode of action of the
      subclass of proline-rich antimicrobial peptides (PrAMPs) is not based on
      disruption of the bacterial membrane. Instead, PrAMPs exploit the inner membrane
      transporters SbmA and YjiL/MdtM to pass through the bacterial membrane and enter
      the cytosol of specific Gram-negative bacteria, where they exert an inhibitory
      effect on protein synthesis. Despite sharing a high proline and arginine content
      with other characterized PrAMPs, the PrAMP Bac5 has a low sequence identity with
      them. Here we investigated the mode of action of three N-terminal Bac5 fragments,
      Bac5(1-15), Bac5(1-25), and Bac5(1-31). We show that Bac5(1-25) and Bac5(1-31)
      retained excellent antimicrobial activity toward Escherichia coli and low
      toxicity toward eukaryotic cells, whereas Bac5(1-15) was inactive. Bac5(1-25) and
      Bac5(1-31) inhibited bacterial protein synthesis in vitro and in vivo Competition
      assays suggested that the binding site of Bac5 is within the ribosomal tunnel,
      where it prevents the transition from the initiation to the elongation phase of
      translation, as reported for other PrAMPs, such as the bovine PrAMP Bac7.
      Surprisingly, unlike Bac7, Bac5(1-25) exhibited species-specific inhibition,
      being an excellent inhibitor of protein synthesis on E. coli ribosomes but a poor
      inhibitor on Thermus thermophilus ribosomes. This indicates that while Bac5 most
      likely has an overlapping binding site with Bac7, the mode of interaction is
      distinct, suggesting that Bac5 fragments may be interesting alternative lead
      compounds for the development of new antimicrobial agents.

PMID- 29844041
TI  - Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa.
AB  - Whole-genome sequencing (WGS) of historical Pseudomonas aeruginosa clinical
      isolates identified a chromosomal copy of mcr-5 within a Tn3-like transposon in
      P. aeruginosa MRSN 12280. The isolate was nonsusceptible to colistin by broth
      microdilution, and genome analysis revealed no mutations known to confer colistin
      resistance. To the best of our knowledge, this is the first report of mcr in
      colistin-nonsusceptible P. aeruginosa.

PMID- 29844042
TI  - Lipopeptide Paenipeptin Analogues Potentiate Clarithromycin and Rifampin against
      Carbapenem-Resistant Pathogens.
AB  - Two paenipeptin analogues at 4 MUg/ml potentiated clarithromycin and rifampin
      against carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae
      strains. The combined treatment significantly increased their antibacterial
      efficacy in a microbiological medium and in human serum in vitro at
      therapeutically relevant concentrations. Moreover, these two paenipeptin
      analogues showed low cytotoxicity against a human kidney cell line. Therefore,
      combination therapy with paenipeptins may be an option for the treatment of
      antibiotic-resistant bacterial infections.

PMID- 29844043
TI  - Comparison of In Vitro Activity and MIC Distributions between the Novel
      Oxazolidinone Delpazolid and Linezolid against Multidrug-Resistant and
      Extensively Drug-Resistant Mycobacterium tuberculosis in China.
AB  - Oxazolidinones are efficacious in treating mycobacterial infections, including
      tuberculosis (TB) caused by drug-resistant Mycobacterium tuberculosis In this
      study, we compared the in vitro activities and MIC distributions of delpazolid, a
      novel oxazolidinone, and linezolid against multidrug-resistant TB (MDR-TB) and
      extensively drug-resistant TB (XDR-TB) in China. Additionally, genetic mutations
      in 23S rRNA, rplC, and rplD genes were analyzed to reveal potential mechanisms
      underlying the observed oxazolidinone resistance. A total of 240 M. tuberculosis
      isolates were included in this study, including 120 MDR-TB isolates and 120 XDR
      TB isolates. Overall, linezolid and delpazolid MIC90 values for M. tuberculosis
      isolates were 0.25 mg/liter and 0.5 mg/liter, respectively. Based on visual
      inspection, we tentatively set epidemiological cutoff (ECOFF) values for MIC
      determinations for linezolid and delpazolid at 1.0 mg/liter and 2.0 mg/liter,
      respectively. Although no significant difference in resistance rates was observed
      between linezolid and delpazolid among XDR-TB isolates (P > 0.05), statistical
      analysis revealed a significantly greater proportion of linezolid-resistant
      isolates than delpazolid-resistant isolates within the MDR-TB group (P = 0.036).
      Seven (53.85%) of 13 linezolid-resistant isolates were found to harbor mutations
      within the three target genes. Additionally, 1 isolate exhibited an amino acid
      substitution (Arg126His) within the protein encoded by rplD that contributed to
      high-level resistance to linezolid (MIC of >16 mg/liter), compared to a
      delpazolid MIC of 0.25. In conclusion, in vitro susceptibility testing revealed
      that delpazolid antibacterial activity was comparable to that of linezolid. A
      novel mutation within rplD that endowed M. tuberculosis with linezolid, but not
      delpazolid, resistance was identified.

PMID- 29844045
TI  - Disruption of mpl Activates beta-Lactamase Production in Stenotrophomonas
      maltophilia and Pseudomonas aeruginosa Clinical Isolates.
AB  - The hyperproduction of chromosomally encoded beta-lactamases is a key method of
      acquired resistance to ceftazidime, aztreonam, and, when seen in backgrounds
      having reduced envelope permeability, carbapenems. Here, we show that the loss of
      Mpl, a UDP-muramic acid/peptide ligase, is a common and previously overlooked
      cause of chromosomally encoded beta-lactamase hyperproduction in clinical
      isolates of Stenotrophomonas maltophilia and Pseudomonas aeruginosa, important
      pathogens notorious for their beta-lactam-resistant phenotypes.

PMID- 29844044
TI  - Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition
      Metals.
AB  - The lack of information regarding the mechanisms of action (MoA) or specific
      molecular targets of phenotypically active compounds can prove a barrier to their
      development as chemotherapeutic agents. Here, we report the results of our
      orthogonal genetic, molecular, and biochemical studies to determine the MoA of a
      novel 7-substituted 8-hydroxy-1,6-naphthyridine (8-HNT) series that displays
      promising activity against Trypanosoma brucei and Leishmania donovani High
      throughput loss-of-function genetic screens in T. brucei highlighted two probable
      zinc transporters associated with resistance to these compounds. These
      transporters localized to the parasite Golgi apparatus. Directed by these
      findings, the role of zinc and other divalent cations in the MoA of these
      compounds was investigated. 8-HNT compounds were found to directly deplete
      intracellular levels of Zn2+, while the addition of exogenous Zn2+ and Fe2+
      reduced the potency of compounds from this series. Detailed biochemical analyses
      confirmed that 8-HNT compounds bind directly to a number of divalent cations,
      predominantly Zn2+, Fe2+, and Cu2+, forming 2:1 complexes with one of these
      cations. Collectively, our studies demonstrate transition metal depletion, due to
      chelation, as the MoA of the 8-HNT series of compounds. Strategies to improve the
      selectivity of 8-HNT compounds are discussed.

PMID- 29844046
TI  - Recommendations To Address the Difficulties Encountered When Determining
      Linezolid Resistance from Whole-Genome Sequencing Data.
AB  - Mutations associated with linezolid resistance within the V domain of 23S rRNA
      are annotated using an Escherichia coli numbering system. The 23S rRNA gene
      varies in length, nucleotide sequence, and copy number among bacterial species.
      Consequently, this numbering system is not intuitive and can lead to confusion
      when mutation sites are being located using whole-genome sequencing data. Using
      the mutation G2576T as an example, we demonstrate the difficulties associated
      with using the E. coli numbering system.

PMID- 29844047
TI  - Clofazimine for the Treatment of Mycobacterium kansasii.
AB  - Mycobacterium kansasii pulmonary infection is a global problem. Standard
      combination therapy consists of isoniazid at 300 mg/day, rifampin at 600 mg/day,
      and ethambutol at 15 mg/kg of body weight/day for 18 months. Coincubation of M.
      kansasii with different clofazimine concentrations over 7 days in test tubes
      resulted in a maximal kill (maximum effect [Emax]) of 2.03 log10 CFU/ml below the
      day 0 bacterial burden. The concentration associated with Emax was 110 times the
      MIC. Next, the effects of human-like concentration-time profiles of clofazimine
      human-equivalent doses ranging from 0 to 200 mg daily for 21 days were examined
      in the hollow-fiber model of intracellular M. kansasii (HFS-Mkn). On day 14, when
      the clofazimine microbial effect was maximal, the Emax was 2.57 log10 CFU/ml,
      while the dose associated with Emax was 100 mg/day. However, no dose killed M.
      kansasii to levels below the day 0 bacterial burden. Thus, the antimicrobial
      effect of clofazimine monotherapy in the HFS-Mkn was modest. Human-equivalent
      concentration-time profiles of standard combination therapy and doses were used
      as comparators in the HFS-Mkn On day 14, standard therapy killed to a level 2.32
      log10 CFU/ml below the day 0 bacterial burden. The effect of standard therapy was
      consistent with a biexponential decline, with kill rate constants of 1.85 per day
      (half-life = 0.37 days) and 0.06 per day (half-life = 12.76 days) (r2 > 0.99).
      This means that standard therapy would take 9.3 to 12 months to completely
      eliminate M. kansasii in the model, which is consistent with clinical
      observations. This observation for standard therapy means that the modest to poor
      effect of clofazimine on M. kansasii identified here is likely to be the same in
      the clinic.

PMID- 29844048
TI  - Iron Restriction to Clinical Isolates of Candida albicans by the Novel Chelator
      DIBI Inhibits Growth and Increases Sensitivity to Azoles In Vitro and In Vivo in
      a Murine Model of Experimental Vaginitis.
AB  - Candida albicans is an important opportunistic pathogen causing various human
      infections that are often treated with azole antifungals. The U.S. CDC now
      regards developing candidal antifungal resistance as a threat, creating a need
      for new and more effective antifungal treatments. Iron is an essential nutrient
      for all living cells, and there is growing evidence that interference with iron
      homeostasis of C. albicans can improve its response to antifungals. This study
      was aimed at establishing whether withholding iron by currently used medical iron
      chelators and the novel chelator DIBI could restrict growth and also enhance the
      activity of azoles against clinical isolates of C. albicans DIBI, but not
      deferoxamine or deferiprone, inhibited the growth of C. albicans at relatively
      low concentrations in vitro, and this inhibition was reversed by iron addition.
      DIBI in combination with various azoles demonstrated stronger growth inhibition
      than the azoles alone and greatly prolonged the inhibition of cell
      multiplication. In addition, the administration of DIBI along with fluconazole
      (FLC) to mice inoculated with an FLC-sensitive isolate in a model of experimental
      C. albicans vaginitis showed a markedly improved clearance of infection. These
      results suggest that iron chelation by DIBI has the potential to enhance azole
      efficacy for the treatment of candidiasis.

PMID- 29844049
TI  - Analysis of the Tunicamycin Biosynthetic Gene Cluster of Streptomyces chartreusis
      Reveals New Insights into Tunicamycin Production and Immunity.
AB  - The tunicamycin biosynthetic gene cluster of Streptomyces chartreusis consists of
      14 genes (tunA to tunN) with a high degree of apparent translational coupling.
      Transcriptional analysis revealed that all of these genes are likely to be
      transcribed as a single operon from two promoters, tunp1 and tunp2. In-frame
      deletion analysis revealed that just six of these genes (tunABCDEH) are essential
      for tunicamycin production in the heterologous host Streptomyces coelicolor,
      while five (tunFGKLN) with likely counterparts in primary metabolism are not
      necessary, but presumably ensure efficient production of the antibiotic at the
      onset of tunicamycin biosynthesis. Three genes are implicated in immunity,
      namely, tunI and tunJ, which encode a two-component ABC transporter presumably
      required for export of the antibiotic, and tunM, which encodes a putative S
      adenosylmethionine (SAM)-dependent methyltransferase. Expression of tunIJ or tunM
      in S. coelicolor conferred resistance to exogenous tunicamycin. The results
      presented here provide new insights into tunicamycin biosynthesis and immunity.

PMID- 29844050
TI  - Antimicrobial Efficacy and Safety of a Novel Gas Plasma-Activated Catheter Lock
      Solution.
AB  - Antimicrobial lock solutions are important for prevention of microbial
      colonization and infection of long-term central venous catheters. We investigated
      the efficacy and safety of a novel antibiotic-free lock solution formed from gas
      plasma-activated disinfectant (PAD). Using a luminal biofilm model, viable cells
      of methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis,
      Pseudomonas aeruginosa, and Candida albicans in mature biofilms were reduced by 6
      to 8 orders of magnitude with a PAD lock for 60 min. Subsequent 24-h incubation
      of PAD-treated samples resulted in no detectable regrowth of viable bacteria or
      fungi. As a comparison, the use of a minocycline-EDTA-ethanol lock solution for
      60 min led to regrowth of bacteria and fungi, up to 107 to 109 CFU/ml, in 24 h.
      The PAD lock solution had minimal impact on human umbilical vein endothelial cell
      viability, whereas the minocycline-EDTA-ethanol solution elicited cell death in
      nearly half of human endothelial cells. Additionally, PAD treatment caused little
      topological change to catheter materials. In conclusion, PAD represents a novel
      antibiotic-free, noncytotoxic lock solution that elicits rapid and broad-spectrum
      eradication of biofilm-laden microbes and shows promise for the prevention and
      treatment of intravascular catheter infections.

PMID- 29844051
TI  - Miltefosine Has a Postantifungal Effect and Induces Apoptosis in Cryptococcus
      Yeasts.
AB  - Cryptococcus spp. are common opportunistic fungal pathogens, particularly in HIV
      patients. The approved drug miltefosine (MFS) has potential as an alternative
      antifungal against cryptococcosis; however, the mechanism of action of MFS in
      Cryptococcus is poorly understood. Here, we examined the effects of MFS on C.
      neoformans and C. gattii yeasts (planktonic and biofilm lifestyles) to clarify
      its mechanism of action. MFS presented inhibitory and fungicidal effects against
      planktonic Cryptococcus cells, with similar activities against dispersion biofilm
      cells, while sessile biofilm cells were less sensitive to MFS. Interestingly, MFS
      had postantifungal effect on Cryptococcus, with a proliferation delay of up to
      8.15 h after a short exposure to fungicidal doses. MFS at fungicidal
      concentrations increased the plasma membrane permeability, likely due to a direct
      interaction with ergosterol, as suggested by competition assays with exogenous
      ergosterol. Moreover, MFS reduced the mitochondrial membrane potential, increased
      reactive oxygen species (ROS) production, and induced DNA fragmentation and
      condensation, all of which are hallmarks of apoptosis. Transmission electron
      microscopy analysis showed that MFS-treated yeasts had a reduced
      mucopolysaccharide capsule (confirmed by morphometry with light microscopy),
      plasma membrane irregularities, mitochondrial swelling, and a less conspicuous
      cell wall. Our results suggest that MFS increases the plasma membrane
      permeability in Cryptococcus via an interaction with ergosterol and also affects
      the mitochondrial membrane, eventually leading to apoptosis, in line with its
      fungicidal activity. These findings confirm the potential of MFS as an antifungal
      against C. neoformans and C. gattii and warrant further studies to establish
      clinical protocols for MFS use against cryptococcosis.

PMID- 29844052
TI  - R-Ras2 is required for germinal center formation to aid B cells during
      energetically demanding processes.
AB  - Upon antigen recognition within peripheral lymphoid organs, B cells interact with
      T cells and other immune cells to transiently form morphological structures
      called germinal centers (GCs), which are required for B cell clonal expansion,
      immunoglobulin class switching, and affinity maturation. This process, known as
      the GC response, is an energetically demanding process that requires the
      metabolic reprogramming of B cells. We showed that the Ras-related guanosine
      triphosphate hydrolase (GTPase) R-Ras2 (also known as TC21) plays an essential,
      nonredundant, and B cell-intrinsic role in the GC response. Both the conversion
      of B cells into GC B cells and their expansion were impaired in mice lacking R
      Ras2, but not in those lacking a highly related R-Ras subfamily member or both
      the classic H-Ras and N-Ras GTPases. In the absence of R-Ras2, activated B cells
      did not exhibit increased oxidative phosphorylation or aerobic glycolysis. We
      showed that R-Ras2 was an effector of both the B cell receptor (BCR) and CD40 and
      that, in its absence, B cells exhibited impaired activation of the PI3K-Akt
      mTORC1 pathway, reduced mitochondrial DNA replication, and decreased expression
      of genes involved in glucose metabolism. Because most human B cell lymphomas
      originate from GC B cells or B cells that have undergone the GC response, our
      data suggest that R-Ras2 may also regulate metabolism in B cell malignancies.

PMID- 29844053
TI  - Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and
      lysyl oxidase precursors and collagen cross-linking sites.
AB  - Fibrillar collagens of the extracellular matrix are critical for tissue structure
      and physiology; however, excessive or abnormal deposition of collagens is a
      defining feature of fibrosis. Regulatory mechanisms that act on collagen fibril
      assembly potentially offer new targets for antifibrotic treatments. Tissue
      weakening, altered collagen fibril morphologies, or both, are shared phenotypes
      of mice lacking matricellular thrombospondins. Thrombospondin-1 (TSP1) plays an
      indirect role in collagen homeostasis through interactions with matrix
      metalloproteinases and transforming growth factor-beta1 (TGF-beta1). We found
      that TSP1 also affects collagen fibril formation directly. Compared to skin from
      wild-type mice, skin from Thbs1-/- mice had reduced collagen cross-linking and
      reduced prolysyl oxidase (proLOX) abundance with increased conversion to
      catalytically active LOX. In vitro, TSP1 bound to both the C-propeptide domain of
      collagen I and the highly conserved KGHR sequences of the collagen triple-helical
      domain that participate in cross-linking. TSP1 also bound to proLOX and inhibited
      proLOX processing by bone morphogenetic protein-1. In human dermal fibroblasts
      (HDFs), TSP1 and collagen I colocalized in intracellular vesicles and on
      extracellular collagen fibrils, whereas TSP1 and proLOX colocalized only in
      intracellular vesicles. Inhibition of LOX-mediated collagen cross-linking did not
      prevent the extracellular association between collagen and TSP1; however,
      treatment of HDFs with KGHR-containing, TSP1-binding, triple-helical peptides
      disrupted the collagen-TSP1 association, perturbed the collagen extracellular
      matrix, and increased myofibroblastic differentiation in a manner that depended
      on TGF-beta receptor 1. Thus, the extracellular KGHR-dependent interaction of
      TSP1 with fibrillar collagens contributes to fibroblast homeostasis.

PMID- 29844054
TI  - Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment
      epithelium.
AB  - The retinal pigment epithelium (RPE) transports nutrients and metabolites between
      the microvascular bed that maintains the outer retina and photoreceptor neurons.
      The RPE removes photoreceptor outer segments (POS) by receptor-mediated
      phagocytosis, a process that peaks in the morning. Uptake and degradation of POS
      initiates signaling cascades in the RPE. Upstream stimuli from various metabolic
      activities converge on mechanistic target of rapamycin complex 1 (mTORC1), and
      aberrant mTORC1 signaling is implicated in aging and age-related degeneration of
      the RPE. We measured mTORC1-mediated responses to RPE phagocytosis in vivo and in
      vitro. During the morning burst of POS shedding, there was transient activation
      of mTORC1-mediated signaling in the RPE. POS activated mTORC1 through lysosome
      independent mechanisms, and engulfed POS served as a docking platform for mTORC1
      assembly. The identification of POS as endogenous stimuli of mTORC1 in the RPE
      provides a mechanistic link underlying the photoreceptor-RPE interaction in the
      outer retina.

PMID- 29844055
TI  - Dual phosphorylation of Ric-8A enhances its ability to mediate G protein alpha
      subunit folding and to stimulate guanine nucleotide exchange.
AB  - Resistance to inhibitors of cholinesterase-8A (Ric-8A) and Ric-8B are essential
      biosynthetic chaperones for heterotrimeric G protein alpha subunits. We provide
      evidence for the direct regulation of Ric-8A cellular activity by dual
      phosphorylation. Using proteomics, Western blotting, and mutational analyses, we
      determined that Ric-8A was constitutively phosphorylated at five serines and
      threonines by the protein kinase CK2. Phosphorylation of Ser435 and Thr440 in rat
      Ric-8A (corresponding to Ser436 and Thr441 in human Ric-8A) was required for high
      affinity binding to Galpha subunits, efficient stimulation of Galpha subunit
      guanine nucleotide exchange, and mediation of Galpha subunit folding. The CK2
      consensus sites that contain Ser435 and Thr440 are conserved in Ric-8 homologs
      from worms to mammals. We found that the homologous residues in mouse Ric-8B,
      Ser468 and Ser473, were also phosphorylated. Mutation of the genomic copy of ric
      8 in Caenorhabditis elegans to encode alanine in the homologous sites resulted in
      characteristic ric-8 reduction-of-function phenotypes that are associated with
      defective Gq and Gs signaling, including reduced locomotion and defective egg
      laying. The C. elegans ric-8 phosphorylation site mutant phenotypes were
      partially rescued by chemical stimulation of Gq signaling. These results indicate
      that dual phosphorylation represents a critical form of conserved Ric-8
      regulation and demonstrate that Ric-8 proteins are needed for effective Galpha
      signaling. The position of the CK2-phosphorylated sites within a structural model
      of Ric-8A reveals that these sites contribute to a key acidic and negatively
      charged surface that may be important for its interactions with Galpha subunits.

PMID- 29844056
TI  - Clinical Pharmacology in HIV Therapy.
AB  - The success of combination antiretroviral therapy in the treatment of HIV-1
      positive individuals has shifted clinical attention toward combination
      antiretroviral drug regimens that optimize tolerability, long-term safety, and
      durable efficacy. Wherever patients have access to treatment, morbidity and
      mortality are increasingly driven by non-HIV-associated comorbidities, which may
      be observed earlier than in age-matched controls and despite the best available
      combination antiretroviral therapy. Similarly, HIV-1-positive individuals are now
      diagnosed and treated earlier with anticipated lifelong therapy. The contribution
      of specific antiretroviral agents to long-term morbidity and mortality is
      dependent on the pharmacologic characteristics of these agents, and it is
      increasingly important in this context.

PMID- 29844057
TI  - Riboswitches and Translation Control.
AB  - A growing collection of bacterial riboswitch classes is being discovered that
      sense central metabolites, coenzymes, and signaling molecules. Included among the
      various mechanisms of gene regulation exploited by these RNA regulatory elements
      are several that modulate messenger RNA (mRNA) translation. In this review, the
      mechanisms of riboswitch-mediated translation control are summarized to highlight
      both their diversity and potential ancient origins. These mechanisms include
      ligand-gated presentation or occlusion of ribosome-binding sites, control of
      alternative splicing of mRNAs, and the regulation of mRNA stability. Moreover,
      speculation on the potential for novel riboswitch discoveries is presented,
      including a discussion on the potential for the discovery of a greater diversity
      of mechanisms for translation control.

PMID- 29844058
TI  - A Teenage Girl with Unexpected Pubertal Changes.

PMID- 29844059
TI  - Commentary.

PMID- 29844060
TI  - Commentary.

PMID- 29844061
TI  - Argininemia, Hyperornithinemia, and 3-Hydroxyisovaleric Aciduria.

PMID- 29844062
TI  - Waiting for Severe Hyperbilirubinemia.

PMID- 29844063
TI  - A 69-Year-Old Woman with Markedly Decreased Cholesterol.

PMID- 29844064
TI  - "Quiet Waters".

PMID- 29844067
TI  - Safe staffing legislation will be introduced in Scotland.

PMID- 29844065
TI  - The Interaction between the Ribosomal Stalk Proteins and Translation Initiation
      Factor 5B Promotes Translation Initiation.
AB  - Ribosomal stalk proteins recruit translation elongation GTPases to the factor
      binding center of the ribosome. Initiation factor 5B (eIF5B in eukaryotes and
      aIF5B in archaea) is a universally conserved GTPase that promotes the joining of
      the large and small ribosomal subunits during translation initiation. Here we
      show that aIF5B binds to the C-terminal tail of the stalk protein. In the
      cocrystal structure, the interaction occurs between the hydrophobic amino acids
      of the stalk C-terminal tail and a small hydrophobic pocket on the surface of the
      GTP-binding domain (domain I) of aIF5B. A substitution mutation altering the
      hydrophobic pocket of yeast eIF5B resulted in a marked reduction in ribosome
      dependent eIF5B GTPase activity in vitro In yeast cells, the eIF5B mutation
      affected growth and impaired GCN4 expression during amino acid starvation via a
      defect in start site selection for the first upstream open reading frame in GCN4
      mRNA, as observed with the eIF5B deletion mutant. The deletion of two of the four
      stalk proteins diminished polyribosome levels (indicating defective translation
      initiation) and starvation-induced GCN4 expression, both of which were
      suppressible by eIF5B overexpression. Thus, the mutual interaction between
      a/eIF5B and the ribosomal stalk plays an important role in subunit joining during
      translation initiation in vivo.

PMID- 29844068
TI  - Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug
      Discovery.

PMID- 29844066
TI  - DIFFERENTIAL ROLE OF THE RasGEFs SOS1 AND SOS2 IN MOUSE SKIN HOMEOSTASIS AND
      CARCINOGENESIS.
AB  - Using Sos1-KO, Sos2-KO and Sos1/2-DKO mice, we assessed the functional role of
      Sos1 and Sos2 in skin homeostasis under physiological and/or pathological
      conditions. Sos1 depletion resulted in significant alterations of skin
      homeostasis including reduced keratinocyte proliferation, altered hair follicle
      and blood vessel integrity in dermis, and reduced adipose tissue in hypodermis.
      These defects worsened significantly when both Sos1 and Sos2 were absent.
      Simultaneous Sos1/2 disruption led to severe impairment of the ability to repair
      skin wounds as well as to almost complete ablation of the neutrophil-mediated
      inflammatory response in the injury site. Furthermore, Sos1 disruption delayed
      the onset of tumor initiation, decreased tumor growth and prevented malignant
      progression of papillomas in a DMBA/TPA-induced skin carcinogenesis model.
      Finally, Sos1 depletion in preexisting chemically-induced papillomas resulted
      also in decreased tumor growth, probably linked to significantly reduced
      underlying keratinocyte proliferation.Our data unveil novel, distinctive
      mechanistic roles of Sos 1 and Sos2 in physiological control of skin homeostasis
      and wound repair as well as in pathological development of chemically induced
      skin tumors. These observations underscore the essential role of Sos proteins in
      cellular proliferation and migration and support the consideration of these
      RasGEFs as potential biomarkers/therapy targets in Ras-driven epidermal tumors.

PMID- 29844069
TI  - Public Reporting III: Improving the Value of Public Physician Quality
      Information.

PMID- 29844070
TI  - Suboptimal Outcome of Myocardial Infarction After Noncardiac Surgery: Physicians
      Can and Should Do More.

PMID- 29844071
TI  - Hypertension in China: Time to Transition From Knowing the Problem to
      Implementing the Solution.

PMID- 29844072
TI  - New Therapeutic Approaches in Pulmonary Arterial Hypertension: The Pantheon Is
      Getting Crowded.

PMID- 29844073
TI  - Energetics of Blood Flow in Cardiovascular Disease: Concept and Clinical
      Implications of Adverse Energetics in Patients With a Fontan Circulation.
AB  - Visualization and quantification of the adverse effects of distorted blood flow
      are important emerging fields in cardiology. Abnormal blood flow patterns can be
      seen in various cardiovascular diseases and are associated with increased energy
      loss. These adverse energetics can be measured and quantified using 3-dimensional
      blood flow data, derived from computational fluid dynamics and 4-dimensional flow
      magnetic resonance imaging, and provide new, promising hemodynamic markers. In
      patients with palliated single-ventricular heart defects, the Fontan circulation
      passively directs systemic venous return to the pulmonary circulation in the
      absence of a functional subpulmonary ventricle. Therefore, the Fontan circulation
      is highly dependent on favorable flow and energetics, and minimal energy loss is
      of great importance. A focus on reducing energy loss led to the introduction of
      the total cavopulmonary connection (TCPC) as an alternative to the classical
      Fontan connection. Subsequently, many studies have investigated energy loss in
      the TCPC, and energy-saving geometric factors have been implemented in clinical
      care. Great advances have been made in computational fluid dynamics modeling and
      can now be done in 3-dimensional patient-specific models with increasingly
      accurate boundary conditions. Furthermore, the implementation of 4-dimensional
      flow magnetic resonance imaging is promising and can be of complementary value to
      these models. Recently, correlations between energy loss in the TCPC and cardiac
      parameters and exercise intolerance have been reported. Furthermore, efficiency
      of blood flow through the TCPC is highly variable, and inefficient blood flow is
      of clinical importance by reducing cardiac output and increasing central venous
      pressure, thereby increasing the risk of experiencing the well-known Fontan
      complications. Energy loss in the TCPC will be an important new hemodynamic
      parameter in addition to other well-known risk factors such as pulmonary vascular
      resistance and can possibly be improved by patient-specific surgical design. This
      article describes the theoretical background of mechanical energy of blood flow
      in the cardiovascular system and the methods of calculating energy loss, and it
      gives an overview of geometric factors associated with energy efficiency in the
      TCPC and its implications on clinical outcome. Furthermore, the role of 4
      dimensional flow magnetic resonance imaging and areas of future research are
      discussed.

PMID- 29844074
TI  - Letter by Hernandez-Gonzalez et al Regarding Article, "Phenotypic
      Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients
      Diagnosed Clinically With Pulmonary Arterial Hypertension".

PMID- 29844075
TI  - Response by Hadinnapola et al to Letter Regarding Article, "Phenotypic
      Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients
      Diagnosed Clinically With Pulmonary Arterial Hypertension".

PMID- 29844076
TI  - Letter by Lowe et al Regarding Article, "Low-Density Lipoprotein Cholesterol
      Lowering for the Primary Prevention of Cardiovascular Disease Among Men With
      Primary Elevations of Low-Density Lipoprotein Cholesterol Levels of 190 mg/dL or
      Above: Analyses From the WOSCOPS (West of Scotland Coronary Prevention Study) 5
      Year Randomized Trial and 20-Year Observational Follow-Up".

PMID- 29844077
TI  - Letter by Koh Regarding Article, "Low-Density Lipoprotein Cholesterol Lowering
      for the Primary Prevention of Cardiovascular Disease Among Men With Primary
      Elevations of Low-Density Lipoprotein Cholesterol Levels of 190 mg/dL or Above:
      Analyses From the WOSCOPS (West of Scotland Coronary Prevention Study) 5-Year
      Randomized Trial and 20-Year Observational Follow-Up".

PMID- 29844078
TI  - Response by Vallejo-Vaz et al to Letters Regarding Article, "Low-Density
      Lipoprotein Cholesterol Lowering for the Primary Prevention of Cardiovascular
      Disease Among Men With Primary Elevations of Low-Density Lipoprotein Cholesterol
      Levels of 190 mg/dL or Above: Analyses From the WOSCOPS (West of Scotland
      Coronary Prevention Study) 5-Year Randomized Trial and 20-Year Observational
      Follow-Up".

PMID- 29844079
TI  - Letter by Campochiaro et al Regarding Article, "Clinical Features, Management,
      and Outcomes of Immune Checkpoint Inhibitor-Related Cardiotoxicity".

PMID- 29844080
TI  - Response by Thuny et al to Letter Regarding Article, "Clinical Features,
      Management, and Outcomes of Immune Checkpoint Inhibitor-Related Cardiotoxicity".

PMID- 29844081
TI  - Letter by Lema Regarding Article, "The Value of Preoperative Assessment Before
      Noncardiac Surgery in the Era of Value-Based Care".

PMID- 29844082
TI  - Correction to: Angiography Versus Hemodynamics to Predict the Natural History of
      Coronary Stenoses: Fractional Flow Reserve Versus Angiography in Multivessel
      Evaluation 2 Substudy.

PMID- 29844083
TI  - Clinical presentation and management of corneal fistula.
AB  - PURPOSE: To describe the clinical features and management of corneal fistula in
      patients of healed keratitis. METHODS: Medical records of all patients of healed
      keratitis presenting to the cornea clinic from November 2016 to September 2017
      were reviewed. Eightcases of corneal fistula (six true fistulas, two closed
      fistulas) were identified. Six patients were managed with autologous tenon patch
      graft while two patients were managed medically. Various risk factors and
      treatment outcomes of corneal fistulisation were evaluated. RESULTS: The patients
      included two patients of failed therapeutic keratoplasty (with resolved graft
      infection) and six patients of healed keratitis. The age of the patients ranged
      between 10 and 60 years. Five of the patients were male while three were female.
      The size of the fistula measured between 1 and 2 mm. A surrounding cystic area of
      diameter ranging between 1 and 4.5 mm was seen in all the patients. In all of the
      patients, the treating physician missed the diagnosis. Complete healing was noted
      at 6-8 weeks in all the patients who underwent tenon graft. One patient refused
      to undergo any surgery and was lost to follow-up. In another case, surgery was
      deferred due to uncontrolled hypertension and he developed anterior staphyloma
      subsequently. CONCLUSION: Corneal fistula can often be missed in an apparently
      healed perforated corneal ulcer. Tenon patch graft is an effective technique for
      the management of corneal fistula.

PMID- 29844084
TI  - Acute macular neuroretinopathy: pathogenetic insights from optical coherence
      tomography angiography.
AB  - AIM: To describe the optical coherence tomography angiography (OCT-A) features of
      patients affected by acute macular neuroretinopathy (AMN). METHODS: This is a
      prospective, observational, cross-sectional study. Multimodal imaging, including
      spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg,
      Germany) and 6*6 mm swept source OCT-A (ZEISS PLEX Elite 9000; ZEISS, Dublin,
      California), was performed on all patients. The primary outcome measure was
      assessment of the vascular alterations of the superficial (SCP) and deep (DCP)
      capillary plexuses and choriocapillaris (CC). A segmentation of the AMN lesions
      using enface OCT images of photoreceptors-retinal pigment epithelium complex was
      used to discriminate intralesional and extralesional regions on the OCT-A enface
      slabs of the DCP and CC reconstructions. Each OCT-A slab was imported into ImageJ
      V.1.50 and digitally binarised for quantitative analyses. RESULTS: Overall, seven
      patients (mean age 19.4+/-3.2 years, six women) affected by AMN were included.
      The mean best-corrected visual acuity was 0.00+/-0.00 logarithm of the minimum
      angle of resolution. Twelve healthy age-matched subjects (mean age 22+/-3.4
      years, 10 women) represented the control group. The quantitative analysis of
      global vessel densities showed that the CC vessel density was significantly lower
      in patients with AMN (0.495+/-0.03) compared with the age-matched controls
      (0.545+/-0.02) (corrected p=0.0003). The intralesional vessel density of the DCP
      was 0.349+/-0.04 in AMN and vs 0.497+/-0.02 in the controls (corrected p=0.0002).
      CONCLUSIONS: Our study confirmed inner choroidal vascular flow void as a possible
      pathogenetic mechanism of AMN. We also found a focal impairment of the DCP within
      the AMN lesions. Future studies are needed to clarify which is the primary
      location of the vascular insult in this condition.

PMID- 29844085
TI  - Outcomes of ultrathin Descemet stripping automated endothelial keratoplasty (UT
      DSAEK) performed in eyes with failure of primary Descemet membrane endothelial
      keratoplasty (DMEK).
AB  - AIM: To evaluate the outcomes of ultrathin Descemet stripping automated
      endothelial keratoplasty (UT-DSAEK) performed in eyes after failure of primary
      Descemet membrane endothelial keratoplasty (DMEK). METHODS: This was a
      retrospective, non-comparative interventional case series done in a tertiary care
      hospital. The study group included 21 eyes of patients which underwent UT-DSAEK
      following the failure of primary DMEK. Outcome measures included best spectacle
      corrected visual acuity (BSCVA) and endothelial cell density (ECD) both recorded
      6 and 12 months postoperatively as well as central graft thickness (CGT) measured
      6 months after UT-DSAEK. RESULTS: When considering only eyes without
      comorbidities (17 of 21), 12 months after UT-DSAEK, BSCVA was >=20/25 in 12/13
      (92%) eyes and >=20/20 in 4/13 (30%) eyes. Mean ECD loss rate was 38.9% at 12
      months postoperatively (range 8%-57%). Six months postoperatively, CGT averaged
      at 81+/-34 um (range 34-131 um). No intraoperative complications were recorded.
      Postoperatively, one patient (no. 8) had graft wrinkles that were fixed 2 days
      following UT-DSAEK. Four patients have developed intraocular lens (IOL)
      opacification, and two of them underwent IOL exchange. No other postoperative
      complications were recorded. CONCLUSIONS: UT-DSAEK is instrumental in the
      management of primary DMEK graft failure, allowing visual rehabilitation which is
      comparable with that of repeat DMEK.

PMID- 29844086
TI  - White matter microstructural alterations in amblyopic adults revealed by
      diffusion spectrum imaging with systematic tract-based automatic analysis.
AB  - BACKGROUND/AIM: We investigated the microstructural changes in white matter of
      adults with amblyopia using diffusion spectrum imaging with systematic tract
      based automatic analysis of the whole brain. METHODS: Ten adults with amblyopia
      (six women and four men, 33.6+/-10.6 years old on average) and 20 age- and sex
      matched normal-sighted controls were enrolled. The mean generalised fractional
      anisotropy (GFA) was measured in 76 white matter tracts and compared between the
      experimental and control groups using a threshold-free cluster-weighted method
      and t-test. A 2-percentile cut-off was used to identify segments with the
      greatest differences between the two groups. RESULTS: Participants with amblyopia
      had significantly lower GFA values than the controls in 11 segments located in
      nine white matter tracts, which included the following: left arcuate fasciculus,
      left frontal aslant tract, left fornix and left inferior fronto-occipital
      fasciculus of the association fibres; left thalamic radiations of the auditory
      nerve and bilateral optic radiations of the projection fibres; and genu and
      middle temporal gyrus of the callosal fibres. Amblyopic participants had
      statistically higher GFA values in the bilateral uncinate fasciculus than those
      of the controls. CONCLUSION: This preliminary study using whole-brain
      tractographic analysis of white matter reveals association between abnormal early
      visual processing and alterations in brain architecture, which may be related to
      various higher-level deficits, such as audiovisual integration and hand-eye
      coordination in patients with amblyopia.

PMID- 29844087
TI  - Reducing inequity of cataract blindness and vision impairment is a global
      priority, but where is the evidence?
AB  - Throughout the world, people who are socially or economically disadvantaged
      disproportionately experience blindness and vision impairment caused by cataract.
      Reducing vision loss from cataract and its unequal distribution must be a
      priority if the WHO's aim of 'universal eye health' is to be realised. To help
      achieve this, decision-makers and service planners need evidence on which
      strategies improve access to cataract services among disadvantaged populations,
      and under what circumstances. Unfortunately, despite many strategies to improve
      cataract services being implemented in recent decades, evidence of what works,
      for who and in what circumstances is not readily available. This paper summarises
      the extent of the evidence on interventions to reduce inequity of vision loss
      from cataract and makes suggestions for how the evidence base can be
      strengthened.

PMID- 29844088
TI  - Repeatability, interocular correlation and agreement of quantitative swept-source
      optical coherence tomography angiography macular metrics in healthy subjects.
AB  - PURPOSE: To investigate the repeatability, interocular correlation and agreement
      of quantitative swept-source optical coherence tomography angiography (SS-OCTA)
      metrics in healthy subjects. METHODS: Thirty-three healthy normal subjects were
      enrolled. The macula was scanned four times by an SS-OCTA system using the 3 mm*3
      mm mode. The superficial capillary map images were analysed using a MATLAB
      program. A series of parameters were measured: foveal avascular zone (FAZ) area,
      FAZ perimeter, FAZ circularity, parafoveal vessel density, fractal dimension and
      vessel diameter index (VDI). The repeatability of four scans was determined by
      intraclass correlation coefficient (ICC). Then the averaged results were analysed
      for intereye difference, correlation and agreement using paired t-test, Pearson's
      correlation coefficient (r), ICC and Bland-Altman plot. RESULTS: The
      repeatability assessment of the macular metrics exported high ICC values (ranged
      from 0.853 to 0.996). There is no statistically significant difference in the
      OCTA metrics between the two eyes. FAZ area (ICC=0.961, r=0.929) and FAZ
      perimeter (ICC=0.884, r=0.802) showed excellent binocular correlation. Fractal
      dimension (ICC=0.732, r=0.578) and VDI (ICC=0.707, r=0.547) showed moderate
      binocular correlation, while parafoveal vessel density had poor binocular
      correlation. Bland-Altman plots showed the range of agreement was from -0.0763 to
      0.0954 mm2 for FAZ area and from -0.0491 to 0.1136 for parafoveal vessel density.
      CONCLUSIONS: The macular metrics obtained using SS-OCTA showed excellent
      repeatability in healthy subjects. We showed high intereye correlation in FAZ
      area and perimeter, moderate correlation in fractal dimension and VDI, while
      vessel density had poor correlation in normal healthy subjects.

PMID- 29844089
TI  - Why Is DNA Double Stranded? The Discovery of DNA Excision Repair Mechanisms.
AB  - The persistence of hereditary traits over many generations testifies to the
      stability of the genetic material. Although the Watson-Crick structure for DNA
      provided a simple and elegant mechanism for replication, some elementary
      calculations implied that mistakes due to tautomeric shifts would introduce too
      many errors to permit this stability. It seemed evident that some additional
      mechanism(s) to correct such errors must be required. This essay traces the early
      development of our understanding of such mechanisms. Their key feature is the
      cutting out of a section of the strand of DNA in which the errors or damage
      resided, and its replacement by a localized synthesis using the undamaged strand
      as a template. To the surprise of some of the founders of molecular biology, this
      understanding derives in large part from studies in radiation biology, a field
      then considered by many to be irrelevant to studies of gene structure and
      function. Furthermore, genetic studies suggesting mechanisms of mismatch
      correction were ignored for almost a decade by biochemists unacquainted or uneasy
      with the power of such analysis. The collective body of results shows that the
      double-stranded structure of DNA is critical not only for replication but also as
      a scaffold for the correction of errors and the removal of damage to DNA. As
      additional discoveries were made, it became clear that the mechanisms for the
      repair of damage were involved not only in maintaining the stability of the
      genetic material but also in a variety of biological phenomena for increasing
      diversity, from genetic recombination to the immune response.

PMID- 29844091
TI  - Corrigendum.

PMID- 29844093
TI  - C-peptide prevents SMAD3 binding to alpha promoters to inhibit collagen type IV
      synthesis.
AB  - Activation of transforming growth factor beta1 (TGFB1)/SMAD3 signaling may lead
      to additional synthesis of collagen type IV (COL4), which is a major contributor
      to extracellular matrix (ECM) accumulation in diabetic nephropathy (DN). C
      peptide can attenuate fibrosis to have unique beneficial effects in DN. However,
      whether and how C-peptide affects TGFB1/SMAD3-activated COL4 synthesis is
      unclear. In this study, pathological changes, expression of COL4 a1-a5 chains
      (Col4a1-a5), COL4 distribution and protein and TGFB1 and SMAD3 protein were first
      assessed in a rat model of diabetes. Then, rat mesangial cells were treated with
      high glucose (HG) and/or C-peptide to investigate the underlying mechanism.
      Col4a1-a5 expression, COL4 protein and secretion, TGFB1 protein, SMAD3 nuclear
      translocation and binding of SMAD3 to its cognate sites in the promoters of
      Col4a1a2, Col4a3a4 and Col4a5 were measured. It was found that C-peptide
      attenuated glomerular pathological changes and suppressed renal Col4a1-a5 mRNA
      expression, COL4 protein content and TGFB1 protein content. C-peptide had a dose
      dependent effect to inhibit Col4a1-a5 mRNA expression, COL4 protein content and
      secretion, in HG-stimulated mesangial cells. In addition, the HG-induced increase
      in TGFB1 protein content was significantly reduced by C-peptide. Although not
      apparently affecting SMAD3 nuclear translocation, C-peptide prevented SMAD3 from
      binding to its sites in the Col4a1a2, Col4a3a4 and Col4a5 promoters in HG
      stimulated mesangial cells. In conclusion, C-peptide could prevent SMAD3 from
      binding to its sites in the Col4a1a2, Col4a3a4 and Col4a5 promoters, to inhibit
      COL4 generation. These results may provide a mechanism for the alleviation of
      fibrosis in DN by C-peptide.

PMID- 29844094
TI  - PAPP-A and cancer.
AB  - The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor
      (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby
      increasing IGF available for IGF receptor-mediated cell proliferation, migration
      and survival. In many tumors, enhanced IGF receptor signaling is associated with
      tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and
      function, and post-translational inhibitors of PAPP-A expression or proteolytic
      activity. We will then review the evidence supporting an important role for PAPP
      A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.

PMID- 29844090
TI  - Development and Function of the Drosophila Tracheal System.
AB  - The tracheal system of insects is a network of epithelial tubules that functions
      as a respiratory organ to supply oxygen to various target organs. Target-derived
      signaling inputs regulate stereotyped modes of cell specification, branching
      morphogenesis, and collective cell migration in the embryonic stage. In the
      postembryonic stages, the same set of signaling pathways controls highly plastic
      regulation of size increase and pattern elaboration during larval stages, and
      cell proliferation and reprograming during metamorphosis. Tracheal tube
      morphogenesis is also regulated by physicochemical interaction of the cell and
      apical extracellular matrix to regulate optimal geometry suitable for air flow.
      The trachea system senses both the external oxygen level and the metabolic
      activity of internal organs, and helps organismal adaptation to changes in
      environmental oxygen level. Cellular and molecular mechanisms underlying the high
      plasticity of tracheal development and physiology uncovered through research on
      Drosophila are discussed.

PMID- 29844095
TI  - Mexican Carriers of the HNF1A p.E508K Variant Do Not Experience an Enhanced
      Response to Sulfonylureas.
AB  - OBJECTIVE: To assess whether an ethnic-specific variant (p.E508K) in the maturity
      onset diabetes of the young (MODY) gene hepatocyte nuclear factor-1alpha (HNF1A)
      found in Mexicans is associated with higher sensitivity to sulfonylureas, as
      documented in patients with MODY3. RESEARCH DESIGN AND METHODS: We recruited 96
      participants (46 variant carriers and 50 age- and sex-matched noncarriers).
      Response to glipizide (one 2.5-5.0-mg dose), metformin (four 500-mg doses), and
      an oral glucose challenge was evaluated using a previously validated protocol.
      Glucose and insulin levels and their areas under the curve (AUCs) were compared
      between groups. RESULTS: Carriers of the p.E508K variant had a lower maximum
      insulin peak during the glipizide challenge as compared with noncarriers with
      diabetes (P < 0.05). Also, carriers had a lower insulin response after the oral
      glucose challenge. Following an oral glucose tolerance test in the presence of
      metformin, carriers of the p.E508K variant with diabetes had a lower maximum
      insulin peak and total and incremental insulin AUC value as compared with
      noncarriers with diabetes (P < 0.05). A similar but nonsignificant trend was seen
      in participants without type 2 diabetes. CONCLUSIONS: Carriers of variant p.E508K
      in HNF1A have a reduced insulin response rather than the increased sensitivity to
      sulfonylureas seen in patients with MODY3.

PMID- 29844096
TI  - Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated
      Fat or Simple Sugars.
AB  - OBJECTIVE: Nonalcoholic fatty liver disease (i.e., increased intrahepatic
      triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular
      disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the
      main pathways contributing to IHTG. We hypothesized that dietary macronutrient
      composition influences the pathways, mediators, and magnitude of weight gain
      induced changes in IHTG. RESEARCH DESIGN AND METHODS: We overfed 38 overweight
      subjects (age 48 +/- 2 years, BMI 31 +/- 1 kg/m2, liver fat 4.7 +/- 0.9%) 1,000
      extra kcal/day of saturated (SAT) or unsaturated (UNSAT) fat or simple sugars
      (CARB) for 3 weeks. We measured IHTG (1H-MRS), pathways contributing to IHTG
      (lipolysis ([2H5]glycerol) and DNL (2H2O) basally and during euglycemic
      hyperinsulinemia), insulin resistance, endotoxemia, plasma ceramides, and adipose
      tissue gene expression at 0 and 3 weeks. RESULTS: Overfeeding SAT increased IHTG
      more (+55%) than UNSAT (+15%, P < 0.05). CARB increased IHTG (+33%) by
      stimulating DNL (+98%). SAT significantly increased while UNSAT decreased
      lipolysis. SAT induced insulin resistance and endotoxemia and significantly
      increased multiple plasma ceramides. The diets had distinct effects on adipose
      tissue gene expression. CONCLUSIONS: Macronutrient composition of excess energy
      influences pathways of IHTG: CARB increases DNL, while SAT increases and UNSAT
      decreases lipolysis. SAT induced the greatest increase in IHTG, insulin
      resistance, and harmful ceramides. Decreased intakes of SAT could be beneficial
      in reducing IHTG and the associated risk of diabetes.

PMID- 29844098
TI  - Changes to sharing medical records could damage research, report warns.

PMID- 29844097
TI  - Universal Health Coverage in Francophone Sub-Saharan Africa: Assessment of Global
      Health Experts' Confidence in Policy Options.
AB  - Many countries rely on standard recipes for accelerating progress toward
      universal health coverage (UHC). With limited generalizable empirical evidence,
      expert confidence and consensus plays a major role in shaping country policy
      choices. This article presents an exploratory attempt conducted between April and
      September 2016 to measure confidence and consensus among a panel of global health
      experts in terms of the effectiveness and feasibility of a number of policy
      options commonly proposed for achieving UHC in low- and middle-income countries,
      such as fee exemptions for certain groups of people, ring-fenced domestic health
      budgets, and public-private partnerships. To ensure a relative homogeneity of
      contexts, we focused on French-speaking sub-Saharan Africa. We initially used the
      Delphi method to arrive at expert consensus, but since no consensus emerged after
      2 rounds, we adjusted our approach to a statistical analysis of the results from
      our questionnaire by measuring the degree of consensus on each policy option
      through 100 (signifying total consensus) minus the size of the interquartile
      range of the individual scores. Seventeen global health experts from various
      backgrounds, but with at least 20 years' experience in the broad region,
      participated in the 2 rounds of the study. The results provide an initial
      "mapping" of the opinions of a group of experts and suggest interesting lessons.
      For the 18 policy options proposed, consensus emerged only on strengthening the
      supply of quality primary health care services (judged as being effective with a
      confidence score of 79 and consensus score of 90), and on fee exemptions for the
      poorest (judged as being fairly easy to implement with a confidence score of 66
      and consensus score of 85). For none of the 18 common policy options was there
      consensus on both potential effectiveness and feasibility, with very diverging
      opinions concerning 5 policy options. The lack of confidence and consensus within
      the panel seems to reflect the lack of consistent evidence on the proposed policy
      options. This suggests that experts' opinions should be framed within
      strengthened inclusive and "evidence-informed deliberative processes" where the
      trade-offs along the 3 dimensions of UHC-extending the population covered against
      health hazards, expanding the range of services and benefits covered, and
      reducing out-of-pocket expenditures-can be discussed in a transparent and
      contextualized setting.

PMID- 29844099
TI  - Qualitative, multimethod study of behavioural and attitudinal responses to
      cochlear implantation from the patient and healthcare professional perspective in
      Australia and the UK: study protocol.
AB  - INTRODUCTION: The growing prevalence of adults with 'severe or greater' hearing
      loss globally is of great concern, with hearing loss leading to diminished
      communication, and impacting on an individual's quality of life (QoL). Cochlear
      implants (CI) are a recommended device for people with severe or greater,
      sensorineural hearing loss, who obtain limited benefits from conventional hearing
      aids (HA), and through improved speech perception, CIs can improve the QoL of
      recipients. Despite this, utilisation of CIs is low. METHODS AND ANALYSIS: This
      qualitative, multiphase and multimethod dual-site study (Australia and the UK)
      explores patients' and healthcare professionals' behaviours and attitudes to
      cochlear implantation. Participants include general practitioners, audiologists
      and older adults with severe or greater hearing loss, who are HA users, CI users
      and CI candidates. Using purposive time frame sampling, participants will be
      recruited to take part in focus groups or individual interviews, and will each
      complete a demographic questionnaire and a qualitative proforma. The study aims
      to conduct 147 data capture events across a sample of 49 participants, or until
      data saturation occurs. Schema and thematic analysis with extensive group work
      will be used to analyse data alongside reporting of demographic and participant
      characteristics. ETHICS AND DISSEMINATION: Ethics approval for this study was
      granted by Macquarie University (HREC: 5201700539), and the study will abide by
      Australian National Health and Medical Research Council ethical guidelines. Study
      findings will be published through peer-reviewed journal articles, and
      disseminated through public and academic conference presentations, participant
      information sheets and a funders' final report.

PMID- 29844100
TI  - Validation, Intrarater and Interrater Reliability Study of the Lateral-Anterior
      Drawer Test for Detecting Posterior Cruciate Ligament Ruptures: Study Protocol of
      a Prospective Controlled Single-Blinded Cross-Sectional Study.
AB  - INTRODUCTION: Commonly used clinical tests for posterior cruciate ligament (PCL)
      rupture detection exhibit several limitations, thus requiring more precise
      clinical PCL tests. The lateral-anterior drawer (LAD) test has been proposed as a
      manually applied testing alternative but not yet been evaluated in vivo. METHODS
      AND ANALYSIS: Fifteen patients presenting with an MRI-confirmed acute or chronic
      unilateral PCL rupture and 15 subjects with no prior knee injury in their medical
      history will be included in this prospective single-blinded cross-sectional
      cohort study. Three examiners with different lengths of working experience (range
      1-30 years), blinded to MRI outcomes and patient history, will use the LAD test
      on both knees of each participant to test for PCL integrity. Examiners will
      independently document the PCL status of each knee on a blank case report form.
      Fleiss-Kappa values will be calculated to investigate whether the LAD test shows
      clinically significant interrater and intrarater reliability. Furthermore, LAD
      test outcomes will be compared with MRI which serves as reference standard to
      check for concurrent validity. Moreover, LAD test accuracy with respect to tester
      experience will be evaluated. ETHICS AND DISSEMINATION: The study will be
      conducted in agreement with the World Medical Association Declaration of Helsinki
      (2013). Ethical permission (EK16-081-0616) to conduct this study was obtained
      from the review board of the city of Vienna on 1 September 2016. All personal and
      research data will be used in accordance with the Austrian Federal Data
      Protection Act and will be anonymised before publication in relevant
      international peer-reviewed journals. TRIAL REGISTRATIONNUMBER: DRKS00013268; Pre
      results.

PMID- 29844101
TI  - Understanding patient preference for physician attire: a cross-sectional
      observational study of 10 academic medical centres in the USA.
AB  - OBJECTIVE: Several large studies have shown that improving the patient experience
      is associated with higher reported patient satisfaction, increased adherence to
      treatment and clinical outcomes. Whether physician attire can affect the patient
      experience-and how this influences satisfaction-is unknown. Therefore, we
      performed a national, cross-sectional study to examine patient perceptions,
      expectations and preferences regarding physicians dress. SETTING: 10 academic
      hospitals in the USA. PARTICIPANTS: Convenience sample of 4062 patients recruited
      from 1 June 2015 to 31 October 2016. PRIMARY AND SECONDARY OUTCOMES MEASURES: We
      conducted a questionnaire-based study of patients across 10 academic hospitals in
      the USA. The questionnaire included photographs of a male and female physician
      dressed in seven different forms of attire. Patients were asked to rate the
      provider pictured in various clinical settings. Preference for attire was
      calculated as the composite of responses across five domains (knowledgeable,
      trustworthy, caring, approachable and comfortable) via a standardised instrument.
      Secondary outcome measures included variation in preferences by respondent
      characteristics (eg, gender), context of care (eg, inpatient vs outpatient) and
      geographical region. RESULTS: Of 4062 patient responses, 53% indicated that
      physician attire was important to them during care. Over one-third agreed that it
      influenced their satisfaction with care. Compared with all other forms of attire,
      formal attire with a white coat was most highly rated (p=0.001 vs scrubs with
      white coat; p<0.001 all other comparisons). Important differences in preferences
      for attire by clinical context and respondent characteristics were noted. For
      example, respondents>=65 years preferred formal attire with white coats (p<0.001)
      while scrubs were most preferred for surgeons. CONCLUSIONS: Patients have
      important expectations and perceptions for physician dress that vary by context
      and region. Nuanced policies addressing physician dress code to improve patient
      satisfaction appear important.

PMID- 29844102
TI  - Impact of body weight, low energy diet and gastric bypass on drug
      bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol
      for an open, non-randomised, three-armed single centre study (COCKTAIL).
AB  - INTRODUCTION: Roux-en-Y gastric bypass (GBP) is associated with changes in
      cardiometabolic risk factors and bioavailability of drugs, but whether these
      changes are induced by calorie restriction, the weight loss or surgery per se,
      remains uncertain. The COCKTAIL study was designed to disentangle the short-term
      (6 weeks) metabolic and pharmacokinetic effects of GBP and a very low energy diet
      (VLED) by inducing a similar weight loss in the two groups. METHODS AND ANALYSIS:
      This open, non-randomised, three-armed, single-centre study is performed at a
      tertiary care centre in Norway. It aims to compare the short-term (6 weeks) and
      long-term (2 years) effects of GBP and VLED on, first, bioavailability and
      pharmacokinetics (24 hours) of probe drugs and biomarkers and, second, their
      effects on metabolism, cardiometabolic risk factors and biomarkers. The primary
      outcomes will be measured as changes in: (1) all six probe drugs by absolute
      bioavailability area under the curve (AUCoral/AUCiv) of midazolam (CYP3A4 probe),
      systemic exposure (AUCoral) of digoxin and rosuvastatin and drug:metabolite
      ratios for omeprazole, losartan and caffeine, levels of endogenous CYP3A
      biomarkers and genotypic variation, changes in the expression and activity data
      of the drug-metabolising, drug transport and drug regulatory proteins in biopsies
      from various organs and (2) body composition, cardiometabolic risk factors and
      metabolic biomarkers. ETHICS AND DISSEMINATION: The COCKTAIL protocol was
      reviewed and approved by the Regional Committee for Medical and Health Research
      Ethics (Ref: 2013/2379/REK sorost A). The results will be disseminated to
      academic and health professional audiences and the public via presentations at
      conferences, publications in peer-reviewed journals and press releases and
      provided to all participants. TRIAL REGISTRATION NUMBER: NCT02386917.

PMID- 29844104
TI  - Pfizer pays $24m to settle kickback claims over patient assistance charity.

PMID- 29844103
TI  - Establishing a protocol for building a pan-Canadian population-based monitoring
      system for early childhood development for children with health disorders:
      Canadian Children's Health in Context Study (CCHICS).
AB  - INTRODUCTION: Health disorders early in life have tremendous impact on children's
      developmental trajectories. Almost 80% of children with health disorders lack the
      developmental skills to take full advantage of school-based education relative to
      27% of children without a health disorder. In Canada, there is currently a dearth
      of nationally representative data on the social determinants of early childhood
      development for children with health disorders. Evidence from Canada and other
      countries indicate that poorer developmental outcomes in typically developing
      children are associated with lower socioeconomic status (SES). However, to date,
      it is not known whether this relationship is stronger among children with health
      disorders. The study's objectives are to estimate the prevalence and to
      investigate social determinants of developmental outcomes for young children with
      health disorders, using the Early Development Instrument (EDI). METHODS AND
      ANALYSIS: Study objectives will be achieved through three steps. First, using
      existing EDI data for 10 provinces and 2 territories collected from 2004 to 2015,
      we will investigate differences in developmental health outcomes among children
      with identified health disorders. Second, population-level EDI data will be
      linked with neighbourhood sociodemographic census data to explore associations
      between socioeconomic characteristics and rates of specific diagnoses among
      children aged 5-6 years, including trends over time. Third, for 3 of these 12
      regions, additional health and/or education databases will be linked at an
      individual level. These data will be used to establish differences in EDI
      outcomes in relation to the age-of-onset of diagnosis, and presence of
      intervention or treatment. ETHICS AND DISSEMINATION: Study methodologies have
      been approved by the Hamilton Integrated Research Ethics Board. The results of
      the analyses of developmental health outcomes for children with health disorders
      combined with SES will have implications for both health service delivery and
      school-based intervention strategies. Results will contribute to a framework for
      public policy.

PMID- 29844105
TI  - Inhibition of SF3B1 by molecules targeting the spliceosome results in massive
      aberrant exon skipping.
AB  - The recent identification of compounds that interact with the spliceosome
      (sudemycins, spliceostatin A, and meayamycin) indicates that these molecules
      modulate aberrant splicing via SF3B1 inhibition. Through whole transcriptome
      sequencing, we have demonstrated that treatment of Rh18 cells with sudemycin
      leads to exon skipping as the predominant aberrant splicing event. This was also
      observed following reanalysis of published RNA-seq data sets derived from HeLa
      cells after spliceostatin A exposure. These results are in contrast to previous
      reports that indicate that intron retention was the major consequence of SF3B1
      inhibition. Analysis of the exon junctions up-regulated by these small molecules
      indicated that these sequences were absent in annotated human genes, suggesting
      that aberrant splicing events yielded novel RNA transcripts. Interestingly, the
      length of preferred downstream exons was significantly longer than the skipped
      exons, although there was no difference between the lengths of introns flanking
      skipped exons. The reading frame of the aberrantly skipped exons maintained a
      ratio of 2:1:1, close to that of the cassette exons (3:1:1) present in naturally
      occurring isoforms, suggesting negative selection by the nonsense-mediated decay
      (NMD) machinery for out-of-frame transcripts. Accordingly, genes involved in NMD
      and RNAs encoding proteins involved in the splicing process were enriched in both
      data sets. Our findings, therefore, further elucidate the mechanisms by which
      SF3B1 inhibition modulates pre-mRNA splicing.

PMID- 29844107
TI  - Correction for Ballarino et al., "Novel Long Noncoding RNAs (lncRNAs) in
      Myogenesis: a miR-31 Overlapping lncRNA Transcript Controls Myoblast
      Differentiation".

PMID- 29844106
TI  - tRNA fragments (tRFs) guide Ago to regulate gene expression post
      transcriptionally in a Dicer-independent manner.
AB  - tRNA related RNA fragments (tRFs), also known as tRNA-derived RNAs (tdRNAs), are
      abundant small RNAs reported to be associated with Argonaute proteins, yet their
      function is unclear. We show that endogenous 18 nucleotide tRFs derived from the
      3' ends of tRNAs (tRF-3) post-transcriptionally repress genes in HEK293T cells in
      culture. tRF-3 levels increase upon parental tRNA overexpression. This represses
      target genes with a sequence complementary to the tRF-3 in the 3' UTR. The tRF-3
      mediated repression is Dicer-independent, Argonaute-dependent, and the targets
      are recognized by sequence complementarity. Furthermore, tRF-3:target mRNA pairs
      in the RNA induced silencing complex associate with GW182 proteins, known to
      repress translation and promote the degradation of target mRNAs. RNA-seq
      demonstrates that endogenous target genes are specifically decreased upon tRF-3
      induction. Therefore, Dicer-independent tRF-3s, generated upon tRNA
      overexpression, repress genes post-transcriptionally through an Argonaute-GW182
      containing RISC via sequence matches with target mRNAs.

PMID- 29844108
TI  - Correction for Deng et al., "HMGN1 Modulates Nucleosome Occupancy and DNase I
      Hypersensitivity at the CpG Island Promoters of Embryonic Stem Cells".

PMID- 29844109
TI  - Genomic and Geographic Context for the Evolution of High-Risk Carbapenem
      Resistant Enterobacter cloacae Complex Clones ST171 and ST78.
AB  - Recent reports have established the escalating threat of carbapenem-resistant
      Enterobacter cloacae complex (CREC). Here, we demonstrate that CREC has evolved
      as a highly antibiotic-resistant rather than highly virulent nosocomial pathogen.
      Applying genomics and Bayesian phylogenetic analyses to a 7-year collection of
      CREC isolates from a northern Manhattan hospital system and to a large set of
      publicly available, geographically diverse genomes, we demonstrate clonal spread
      of a single clone, ST171. We estimate that two major clades of epidemic ST171
      diverged prior to 1962, subsequently spreading in parallel from the Northeastern
      to the Mid-Atlantic and Midwestern United States and demonstrating links to
      international sites. Acquisition of carbapenem and fluoroquinolone resistance
      determinants by both clades preceded widespread use of these drugs in the mid
      1980s, suggesting that antibiotic pressure contributed substantially to its
      spread. Despite a unique mobile repertoire, ST171 isolates showed decreased
      virulence in vitro While a second clone, ST78, substantially contributed to the
      emergence of CREC, it encompasses diverse carbapenemase-harboring plasmids,
      including a potentially hypertransmissible IncN plasmid, also present in other
      sequence types. Rather than heightened virulence, CREC demonstrates lineage
      specific, multifactorial adaptations to nosocomial environments coupled with a
      unique potential to acquire and disseminate carbapenem resistance genes. These
      findings indicate a need for robust surveillance efforts that are attentive to
      the potential for local and international spread of high-risk CREC
      clones.IMPORTANCE Carbapenem-resistant Enterobacter cloacae complex (CREC) has
      emerged as a formidable nosocomial pathogen. While sporadic acquisition of
      plasmid-encoded carbapenemases has been implicated as a major driver of CREC,
      ST171 and ST78 clones demonstrate epidemic potential. However, a lack of reliable
      genomic references and rigorous statistical analyses has left many gaps in
      knowledge regarding the phylogenetic context and evolutionary pathways of
      successful CREC. Our reconstruction of recent ST171 and ST78 evolution represents
      a significant addition to current understanding of CREC and the directionality of
      its spread from the Eastern United States to the northern Midwestern United
      States with links to international collections. Our results indicate that the
      remarkable ability of E. cloacae to acquire and disseminate cross-class
      antibiotic resistance rather than virulence determinants, coupled with its
      ability to adapt under conditions of antibiotic pressure, likely led to the wide
      dissemination of CREC.

PMID- 29844110
TI  - Reply to Das and Berkhout, "How Polypurine Tract Changes in the HIV-1 RNA Genome
      Can Cause Resistance against the Integrase Inhibitor Dolutegravir".

PMID- 29844111
TI  - A New Family of Capsule Polymerases Generates Teichoic Acid-Like Capsule Polymers
      in Gram-Negative Pathogens.
AB  - Group 2 capsule polymers represent crucial virulence factors of Gram-negative
      pathogenic bacteria. They are synthesized by enzymes called capsule polymerases.
      In this report, we describe a new family of polymerases that combine
      glycosyltransferase and hexose- and polyol-phosphate transferase activity to
      generate complex poly(oligosaccharide phosphate) and poly(glycosylpolyol
      phosphate) polymers, the latter of which display similarity to wall teichoic acid
      (WTA), a cell wall component of Gram-positive bacteria. Using modeling and
      multiple-sequence alignment, we showed homology between the predicted polymerase
      domains and WTA type I biosynthesis enzymes, creating a link between Gram
      negative and Gram-positive cell wall biosynthesis processes. The polymerases of
      the new family are highly abundant and found in a variety of capsule-expressing
      pathogens such as Neisseria meningitidis, Actinobacillus pleuropneumoniae,
      Haemophilus influenzae, Bibersteinia trehalosi, and Escherichia coli with both
      human and animal hosts. Five representative candidates were purified, their
      activities were confirmed using nuclear magnetic resonance (NMR) spectroscopy,
      and their predicted folds were validated by site-directed mutagenesis.IMPORTANCE
      Bacterial capsules play an important role in the interaction between a pathogen
      and the immune system of its host. During the last decade, capsule polymerases
      have become attractive tools for the production of capsule polymers applied as
      antigens in glycoconjugate vaccine formulations. Conventional production of
      glycoconjugate vaccines requires the cultivation of the pathogen and thus the
      highest biosafety standards, leading to tremendous costs. With regard to animal
      husbandry, where vaccines could avoid the extensive use of antibiotics,
      conventional production is not sufficiently cost-effective. In contrast,
      enzymatic synthesis of capsule polymers is pathogen-free and fast, offers high
      stereo- and regioselectivity, and works with high efficacy. The new capsule
      polymerase family described here vastly increases the toolbox of enzymes
      available for biotechnology purposes. Representatives are abundantly found in
      human pathogens but also in animal pathogens, paving the way for the exploitation
      of polymerases for the development of a new generation of vaccines for animal
      husbandry.

PMID- 29844113
TI  - Increased Usage of Antiseptics Is Associated with Reduced Susceptibility in
      Clinical Isolates of Staphylococcus aureus.
AB  - Hospital-acquired infection is a major cause of morbidity and mortality, and
      regimes to prevent infection are crucial in infection control. These include the
      decolonization of vulnerable patients with methicillin-resistant Staphylococcus
      aureus (MRSA) carriage using antiseptics, including chlorhexidine and octenidine.
      Concern has been raised, however, regarding the possible development of biocide
      resistance. In this study, we assembled a panel of S. aureus isolates, including
      isolates collected before the development of chlorhexidine and octenidine and
      isolates, from a major hospital trust in the United Kingdom during a period when
      the decolonization regimes were altered. We observed significant increases in the
      MIC and minimum bactericidal concentration (MBC) of chlorhexidine in isolates
      from periods of high usage of chlorhexidine. Isolates with increased MICs and
      MBCs of octenidine rapidly emerged after octenidine was introduced in the trust.
      There was no apparent cross-resistance between the two biocidal agents. A
      combination of variable-number tandem repeat (VNTR) analysis, PCR for qac genes,
      and whole-genome sequencing was used to type isolates and examine possible
      mechanisms of resistance. There was no expansion of a single strain associated
      with decreased biocide tolerance, and biocide susceptibility did not correlate
      with carriage of qac efflux pump genes. Mutations within the NorA or NorB efflux
      pumps, previously associated with chlorhexidine export, were identified, however,
      suggesting that this may be an important mechanism of biocide tolerance. We
      present evidence that isolates are evolving in the face of biocide challenge in
      patients and that changes in decolonization regimes are reflected in changes in
      susceptibility of isolates.IMPORTANCE Infection in hospitals remains a major
      cause of death and disease. One way in which we combat this is by decolonizing at
      risk patients from carriage of bacteria which can cause disease such as MRSA.
      This is done with antiseptics, including chlorhexidine and octenidine. There is
      concern, however, that bacteria may be able to become resistant to these
      antiseptics. In this study, we looked at isolates of MRSA and found that there
      was a correlation between the use of antiseptics and increased resistance in the
      isolates. We also suggest that the mechanism by which these more tolerant
      isolates may become resistant to antiseptics is that of changing a transport pump
      that exports these agents. This information suggests that we need to study the
      impact of antiseptics on clinically important bacteria more closely.

PMID- 29844112
TI  - Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus
      fumigatus.
AB  - Microbial secondary metabolites, including isocyanide moieties, have been
      extensively mined for their repertoire of bioactive properties. Although the
      first naturally occurring isocyanide (xanthocillin) was isolated from the fungus
      Penicillium notatum over half a century ago, the biosynthetic origins of fungal
      isocyanides remain unknown. Here we report the identification of a family of
      isocyanide synthases (ICSs) from the opportunistic human pathogen Aspergillus
      fumigatus Comparative metabolomics of overexpression or knockout mutants of ICS
      candidate genes led to the discovery of a fungal biosynthetic gene cluster (BGC)
      that produces xanthocillin (xan). Detailed analysis of xanthocillin biosynthesis
      in A. fumigatus revealed several previously undescribed compounds produced by the
      xan BGC, including two novel members of the melanocin family of compounds. We
      found both the xan BGC and a second ICS-containing cluster, named the copper
      responsive metabolite (crm) BGC, to be transcriptionally responsive to external
      copper levels and further demonstrated that production of metabolites from the
      xan BGC is increased during copper starvation. The crm BGC includes a novel type
      of fungus-specific ICS-nonribosomal peptide synthase (NRPS) hybrid enzyme, CrmA.
      This family of ICS-NRPS hybrid enzymes is highly enriched in fungal pathogens of
      humans, insects, and plants. Phylogenetic assessment of all ICSs spanning the
      tree of life shows not only high prevalence throughout the fungal kingdom but
      also distribution in species not previously known to harbor BGCs, indicating an
      untapped resource of fungal secondary metabolism.IMPORTANCE Fungal ICSs are an
      untapped resource in fungal natural product research. Their isocyanide products
      have been implicated in plant and insect pathogenesis due to their ability to
      coordinate transition metals and disable host metalloenzymes. The discovery of a
      novel isocyanide-producing family of hybrid ICS-NRPS enzymes enriched in
      medically and agriculturally important fungal pathogens may reveal mechanisms
      underlying pathogenicity and afford opportunities to discover additional families
      of isocyanides. Furthermore, the identification of noncanonical ICS BGCs will
      enable refinement of BGC prediction algorithms to expand on the secondary
      metabolic potential of fungal and bacterial species. The identification of genes
      related to ICS BGCs in fungal species not previously known for secondary
      metabolite-producing capabilities (e.g., Saccharomyces spp.) contributes to our
      understanding of the evolution of BGC in fungi.

PMID- 29844114
TI  - Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of
      Mycobacterium tuberculosis through Nutrient Auxotrophy.
AB  - Multidrug-resistant (MDR) tuberculosis, defined as tuberculosis resistant to the
      two first-line drugs isoniazid and rifampin, poses a serious problem for global
      tuberculosis control strategies. Lack of a safe and convenient model organism
      hampers progress in combating the spread of MDR strains of Mycobacterium
      tuberculosis We reasoned that auxotrophic MDR mutants of M. tuberculosis would
      provide a safe means for studying MDR M. tuberculosis without the need for a
      biosafety level 3 (BSL3) laboratory. Two different sets of triple auxotrophic
      mutants of M. tuberculosis were generated, which were auxotrophic for the
      nutrients leucine, pantothenate, and arginine or for leucine, pantothenate, and
      methionine. These triple auxotrophic strains retained their acid-fastness, their
      ability to generate both a drug persistence phenotype and drug-resistant mutants,
      and their susceptibility to plaque-forming mycobacterial phages. MDR triple
      auxotrophic mutants were obtained in a two-step fashion, selecting first for
      solely isoniazid-resistant or rifampin-resistant mutants. Interestingly,
      selection for isoniazid-resistant mutants of the methionine auxotroph generated
      isolates with single point mutations in katG, which encodes an isoniazid
      activating enzyme, whereas similar selection using the arginine auxotroph yielded
      isoniazid-resistant mutants with large deletions in the chromosomal region
      containing katG These M. tuberculosis MDR strains were readily sterilized by
      second-line tuberculosis drugs and failed to kill immunocompromised mice. These
      strains provide attractive candidates for M. tuberculosis biology studies and
      drug screening outside the BSL3 facility.IMPORTANCE Elimination of Mycobacterium
      tuberculosis, the bacterium causing tuberculosis, requires enhanced understanding
      of its biology in order to identify new drugs against drug-susceptible and drug
      resistant M. tuberculosis as well as uncovering novel pathways that lead to M.
      tuberculosis death. To circumvent the need for a biosafety level 3 (BSL3)
      laboratory when conducting research on M. tuberculosis, we have generated drug
      susceptible and drug-resistant triple auxotrophic strains of M. tuberculosis
      suitable for use in a BSL2 laboratory. These strains originate from a double
      auxotrophic M. tuberculosis strain, H37Rv DeltapanCD DeltaleuCD, which was
      reclassified as a BSL2 strain based on its lack of lethality in immunocompromised
      and immunocompetent mice. A third auxotrophy (methionine or arginine) was
      introduced via deletion of metA or argB, respectively, since M. tuberculosis
      DeltametA and M. tuberculosis DeltaargB are unable to survive amino acid
      auxotrophy and infect their host. The resulting triple auxotrophic M.
      tuberculosis strains retained characteristics of M. tuberculosis relevant for
      most types of investigations.

PMID- 29844115
TI  - Erratum for Xu et al., "Disruption of Early Tumor Necrosis Factor Alpha Signaling
      Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes
      and Development of Protective Immunity against Cryptococcal Infection".

PMID- 29844116
TI  - Core Concept: "Twisted" light beams promise an optical revolution.

PMID- 29844118
TI  - Integrative Modeling Identifies Key Determinants of Inhibitor Sensitivity in
      Breast Cancer Cell Lines.
AB  - Cancer cell lines differ greatly in their sensitivity to anticancer drugs as a
      result of different oncogenic drivers and drug resistance mechanisms operating in
      each cell line. Although many of these mechanisms have been discovered, it
      remains a challenge to understand how they interact to render an individual cell
      line sensitive or resistant to a particular drug. To better understand this
      variability, we profiled a panel of 30 breast cancer cell lines in the absence of
      drugs for their mutations, copy number aberrations, mRNA, protein expression and
      protein phosphorylation, and for response to seven different kinase inhibitors.
      We then constructed a knowledge-based, Bayesian computational model that
      integrates these data types and estimates the relative contribution of various
      drug sensitivity mechanisms. The resulting model of regulatory signaling
      explained the majority of the variability observed in drug response. The model
      also identified cell lines with an unexplained response, and for these we
      searched for novel explanatory factors. Among others, we found that 4E-BP1
      protein expression, and not just the extent of phosphorylation, was a determinant
      of mTOR inhibitor sensitivity. We validated this finding experimentally and found
      that overexpression of 4E-BP1 in cell lines that normally possess low levels of
      this protein is sufficient to increase mTOR inhibitor sensitivity. Taken
      together, our work demonstrates that combining experimental characterization with
      integrative modeling can be used to systematically test and extend our
      understanding of the variability in anticancer drug response.Significance: By
      estimating how different oncogenic mutations and drug resistance mechanisms
      affect the response of cancer cells to kinase inhibitors, we can better
      understand and ultimately predict response to these anticancer drugs.Graphical
      Abstract:
      http://cancerres.aacrjournals.org/content/canres/78/15/4396/F1.large.jpg Cancer
      Res; 78(15); 4396-410. (c)2018 AACR.

PMID- 29844119
TI  - Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal
      Adenocarcinoma by Dual Genetic Targeting.
AB  - Despite advances in our understanding of the genetics of pancreatic ductal
      adenocarcinoma (PDAC), the efficacy of therapeutic regimens targeting aberrant
      signaling pathways remains highly limited. Therapeutic strategies are greatly
      hampered by the extensive desmoplasia that comprises heterogeneous cell
      populations. Notch signaling is a contentious pathway exerting opposite roles in
      tumorigenesis depending on cellular context. Advanced model systems are needed to
      gain more insights into complex signaling in the multilayered tumor
      microenvironment. In this study, we employed a dual recombinase-based in vivo
      strategy to modulate Notch signaling specifically in myeloid cells to dissect the
      tumorigenic role of Notch in PDAC stroma. Pancreas-specific KrasG12D activation
      and loss of Tp53 was induced using a Pdx1-Flp transgene, whereas Notch signaling
      was genetically targeted using a myeloid-targeting Lyz2-Cre strain for either
      activation of Notch2-IC or deletion of Rbpj. Myeloid-specific Notch activation
      significantly decreased tumor infiltration by protumorigenic M2 macrophages in
      spontaneous endogenous PDAC, which translated into significant survival benefit.
      Further characterization revealed upregulated antigen presentation and cytotoxic
      T effector phenotype upon Notch-induced M2 reduction. This approach is the first
      proof of concept for genetic targeting and reprogramming of myeloid cells in a
      complex disease model of PDAC and provides evidence for a regulatory role of
      Notch signaling in intratumoral immune phenotypes.Significance: This study
      provides insight into the role of myeloid-dependent NOTCH signaling in PDAC and
      accentuates the need to dissect differential roles of signaling pathways in
      different cellular components within the tumor microenvironment. Cancer Res;
      78(17); 4997-5010. (c)2018 AACR.

PMID- 29844121
TI  - Restraining Network Response to Targeted Cancer Therapies Improves Efficacy and
      Reduces Cellular Resistance.
AB  - A key tool of cancer therapy has been targeted inhibition of oncogene-addicted
      pathways. However, efficacy has been limited by progressive emergence of
      resistance as transformed cells adapt. Here, we use Drosophila to dissect
      response to targeted therapies. Treatment with a range of kinase inhibitors led
      to hyperactivation of overall cellular networks, resulting in emergent resistance
      and expression of stem cell markers, including Sox2. Genetic and drug screens
      revealed that inhibitors of histone deacetylases, proteasome, and Hsp90 family of
      proteins restrained this network hyperactivation. These "network brake"
      cocktails, used as adjuncts, prevented emergent resistance and promoted cell
      death at subtherapeutic doses. Our results highlight a general response of cells,
      transformed and normal, to targeted therapies that leads to resistance and
      toxicity. Pairing targeted therapeutics with subtherapeutic doses of broad-acting
      "network brake" drugs may provide a means of extending therapeutic utility while
      reducing whole body toxicity.Significance: These findings with a strong
      therapeutic potential provide an innovative approach of identifying effective
      combination treatments for cancer. Cancer Res; 78(15); 4344-59. (c)2018 AACR.

PMID- 29844120
TI  - Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine
      and 5'-Methylthioadenosine.
AB  - Homozygous deletion of the methylthioadenosine phosphorylase (MTAP) gene is a
      frequent event in a wide variety of human cancers and is a possible molecular
      target for therapy. One potential therapeutic strategy to target MTAP-deleted
      tumors involves combining toxic purine analogues such as 6'-thioguanine (6TG) or
      2'-fluoroadenine (2FA) with the MTAP substrate 5'-deoxy-5'-methylthioadenosine
      (MTA). The rationale is that excess MTA will protect normal MTAP+ cells from
      purine analogue toxicity because MTAP catalyzes the conversion of MTA to adenine,
      which then inhibits the conversion of purine base analogues into nucleotides.
      However, in MTAP- tumor cells, no protection takes place because adenine is not
      formed. Here, we examine the effects of 6TG and 2FA in combination with MTA in
      vitro and in vivoIn vitro, MTA protected against both 6TG and 2FA toxicity in an
      MTAP-dependent manner, shifting the IC50 concentration by one to three orders of
      magnitude. However, in mice, MTA protected against toxicity from 2FA but failed
      to protect against 6TG. Addition of 100 mg/kg MTA to 20 mg/kg 2FA entirely
      reversed the toxicity of 2FA in a variety of tissues and the treatment was well
      tolerated by mice. The 2FA+MTA combination inhibited tumor growth of four
      different MTAP- human tumor cell lines in mouse xenograft models. Our results
      suggest that 2FA+MTA may be a promising combination for treating MTAP-deleted
      tumors.Significance: Loss of MTAP occurs in about 15% of all human cancers; the
      MTAP protection strategy presented in this study could be very effective in
      treating these cancers. Cancer Res; 78(15); 4386-95. (c)2018 AACR.

PMID- 29844122
TI  - Radiotherapy and CD40 Activation Separately Augment Immunity to Checkpoint
      Blockade in Cancer.
AB  - Immunotherapy in pancreatic ductal adenocarcinoma (PDA) remains a difficult
      clinical problem despite success in other disease types with immune checkpoint
      blockade (ICB) and chimeric antigen receptor T-cell therapy. Mechanisms driving
      immunosuppression and poor T-cell infiltration in PDA are incompletely
      understood. Here, we use genetically engineered mouse models of PDA that
      recapitulate hallmarks of human disease to demonstrate that CD40 pathway
      activation is required for clinical response to radiotherapy and ICB with
      alphaCTLA-4 and alphaPD-1. The combination of an agonist alphaCD40 antibody,
      radiotherapy, and dual ICB eradicated irradiated and unirradiated (i.e.,
      abscopal) tumors, generating long-term immunity. Response required T cells and
      also short-lived myeloid cells and was dependent on the long noncoding RNA
      myeloid regulator Morrbid Using unbiased random forest machine learning, we built
      unique, contextual signatures for each therapeutic component, revealing that (i)
      radiotherapy triggers an early proinflammatory stimulus, ablating existing
      intratumoral T cells and upregulating MHC class I and CD86 on antigen-presenting
      cells, (ii) alphaCD40 causes a systemic and intratumoral reorganization of the
      myeloid compartment, and (iii) ICB increases intratumoral T-cell infiltration and
      improves the CD8 T-cell:regulatory T-cell ratio. Thus, alphaCD40 and radiotherapy
      nonredundantly augment antitumor immunity in PDA, which is otherwise refractory
      to ICB, providing a clear rationale for clinical evaluation.Significance:
      Radiotherapy and alphaCD40 disrupt key links between innate and adaptive
      immunity, ameliorating resistance to immune checkpoint blockade in pancreatic
      cancer via multiple cellular mechanisms. Cancer Res; 78(15); 4282-91. (c)2018
      AACR.

PMID- 29844123
TI  - Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in
      Glioblastoma.
AB  - Glioblastoma (GBM) is the most common primary brain malignancy and carries an
      extremely poor prognosis. Recent molecular studies revealed the CDK4/6-Rb-E2F
      axis and receptor tyrosine kinase (RTK) signaling to be deregulated in most GBM,
      creating an opportunity to develop more effective therapies by targeting both
      pathways. Using a phospho-RTK protein array, we found that both c-Met and TrkA-B
      pathways were significantly activated upon CDK4/6 inhibition in GBM cells. We
      therefore investigated the efficacy of combined CDK4/6 and c-Met/TrkA-B
      inhibition against GBM. We show that both c-Met and TrkA-B pathways transactivate
      each other, and targeting both pathways simultaneously results in more efficient
      pathway suppression. Mechanistically, inhibition of CDK4/6 drove NF-kappaB
      mediated upregulation of hepatocyte growth factor, brain-derived neurotrophic
      factor, and nerve growth factor that in turn activated both c-Met and TrkA-B
      pathways. Combining the CDK4/6 inhibitor abemaciclib with the c-Met/Trk inhibitor
      altiratinib or the corresponding siRNAs induced apoptosis, leading to significant
      synergy against GBM. Collectively, these findings demonstrate that the activation
      of c-Met/TrkA-B pathways is a novel mechanism involved in therapeutic resistance
      of GBM to CDK4/6 inhibition and that dual inhibition of c-Met/Trk with CDK4/6
      should be considered in future clinical trials.Significance: CDK4/6 inhibition in
      glioblastoma activates the c-Met and TrkA-B pathways mediated by NF-kappaB and
      can be reversed by a dual c-Met/Trk inhibitor. Cancer Res; 78(15); 4360-9.
      (c)2018 AACR.

PMID- 29844124
TI  - Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in
      Hepatocellular Carcinoma.
AB  - Twist is a critical epithelial-mesenchymal transition (EMT)-inducing
      transcription factor that increases expression of vimentin. How Twist1 regulates
      this expression remains unclear. Here, we report that Twist1 regulates Cullin2
      (Cul2) circular RNA to increase expression of vimentin in EMT. Twist1 bound the
      Cul2 promoter to activate its transcription and to selectively promote expression
      of Cul2 circular RNA (circ-10720), but not mRNA. circ-10720 positively correlated
      with Twist1, tumor malignance, and poor prognosis in hepatocellular carcinoma
      (HCC). Twist1 promoted vimentin expression by increasing levels of circ-10720,
      which can absorb miRNAs that target vimentin. circ-10720 knockdown counteracted
      the tumor-promoting activity of Twist1 in vitro and in patient-derived xenograft
      and diethylnitrosamine-induced TetOn-Twist1 transgenic mouse HCC models. These
      data unveil a mechanism by which Twist1 regulates vimentin during EMT. They also
      provide potential therapeutic targets for HCC treatment and provide new insight
      for circular RNA (circRNA)-based diagnostic and therapeutic
      strategies.Significance: A circRNA-based mechanism drives Twist1-mediated
      regulation of vimentin during EMT and provides potential therapeutic targets for
      treatment of HCC.Graphical Abstract:
      http://cancerres.aacrjournals.org/content/canres/78/15/4150/F1.large.jpg Cancer
      Res; 78(15); 4150-62. (c)2018 AACR.

PMID- 29844126
TI  - The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone
      Deacetylation.
AB  - Oligodendrogliomas are brain tumors accounting for approximately 10% of all
      central nervous system cancers. CIC is a transcription factor that is mutated in
      most patients with oligodendrogliomas; these mutations are believed to be a key
      oncogenic event in such cancers. Analysis of the Drosophila melanogaster ortholog
      of CIC, Capicua, indicates that CIC loss phenocopies activation of the
      EGFR/RAS/MAPK pathway, and studies in mammalian cells have demonstrated a role
      for CIC in repressing the transcription of the PEA3 subfamily of ETS
      transcription factors. Here, we address the mechanism by which CIC represses
      transcription and assess the functional consequences of CIC inactivation. Genome
      wide binding patterns of CIC in several cell types revealed that CIC target genes
      were enriched for MAPK effector genes involved in cell-cycle regulation and
      proliferation. CIC binding to target genes was abolished by high MAPK activity,
      which led to their transcriptional activation. CIC interacted with the SIN3
      deacetylation complex and, based on our results, we suggest that CIC functions as
      a transcriptional repressor through the recruitment of histone deacetylases.
      Independent single amino acid substitutions found in oligodendrogliomas prevented
      CIC from binding its target genes. Taken together, our results show that CIC is a
      transcriptional repressor of genes regulated by MAPK signaling, and that ablation
      of CIC function leads to increased histone acetylation levels and transcription
      at these genes, ultimately fueling mitogen-independent tumor growth.Significance:
      Inactivation of CIC inhibits its direct repression of MAPK pathway genes, leading
      to their increased expression and mitogen-independent growth.Graphical Abstract:
      http://cancerres.aacrjournals.org/content/canres/78/15/4114/F1.large.jpg Cancer
      Res; 78(15); 4114-25. (c)2018 AACR.

PMID- 29844125
TI  - FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is
      Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation.
AB  - Cooperativity between WNT and FGF signaling is well documented in embryonic
      development and cancer progression, but the molecular mechanisms underlying this
      cross-talk remain elusive. In this study, we interrogated the dynamics of RNA
      levels, ribosome occupancy, and protein expression as a function of inducible FGF
      signaling in mouse mammary glands with constitutive WNT hyperactivation.
      Multiomics correlation analysis revealed a substantial discrepancy between RNA
      and ribosome occupancy levels versus protein levels. However, this discrepancy
      decreased as cells became premalignant and dynamically responded to FGF
      signaling, implicating the importance of stringent gene regulation in
      nontransformed cells. Analysis of individual genes demonstrated that acute FGF
      hyperactivation increased translation of many stem cell self-renewal regulators,
      including WNT signaling components, and decreased translation of genes regulating
      cellular senescence. WNT pathway components translationally upregulated by FGF
      signaling had long and structured 5' UTRs with a high frequency of polypurine
      sequences, several of which harbored (CGG)4 motifs that can fold into either
      stable G-quadruplexes or other stable secondary structures. The FGF-mediated
      increase in translation of WNT pathway components was compromised by silvestrol,
      an inhibitor of EIF4A that clamps EIF4A to polypurine sequences to block 43S
      scanning and inhibits its RNA-unwinding activity important for translation
      initiation. Moreover, silvestrol treatment significantly delayed FGF-WNT-driven
      tumorigenesis. Taken together, these results suggest that FGF signaling
      selectively enhances translation of structured mRNAs, particularly WNT signaling
      components, and highlight their vulnerability to inhibitors that target the RNA
      helicase EIF4A.Significance: The RNA helicase EIF4A may serve as a therapeutic
      target for breast cancers that require FGF and WNT signaling. Cancer Res; 78(15);
      4229-40. (c)2018 AACR.

PMID- 29844127
TI  - SNHG6 Acts as a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297
      Mediated S-Adenosylmethionine-Dependent Positive Feedback Loops.
AB  - Aberrant genome-wide hypomethylation and long noncoding RNA (lncRNA)
      dysregulation are associated with hepatocarcinogenesis. However, whether a
      relationship between the two exists remains largely unknown. S-adenosylmethionine
      (SAMe)-dependent methylation is a critical factor in genomic methylation. We
      previously found that SNHG6 lncRNA acted as an oncogene in hepatocarcinogenesis
      and could be considered a potential prognostic indicator for hepatocellular
      carcinoma (HCC). Here we verify that SNHG6 leads to genome-wide hypomethylation
      in hepatoma cells and that SNHG6 negatively correlates with the steady-state SAMe
      concentration in vivo and in vitro SNHG6 suppressed MAT1A protein expression by
      activating the miR-1297/FUS pathway to regulate nucleocytoplasmic shuttling of
      MAT1A mRNA. In addition, SNHG6 promoted expression of MAT2A by suppressing direct
      binding of miR-1297 to the MAT2A 3'UTR. SNHG6 regulated steady-state SAMe levels
      via coupling of two miR-1297-mediated SAMe-dependent positive feedback loops.
      Interestingly, the effect of SNHG6 on genome-wide methylation was inhibited by
      exogenous SAMe within a certain concentration range. These results suggest that
      single lncRNA dysregulation can lead to aberrant genome-wide hypomethylation by
      inhibiting SAMe production in HCC and that exogenous SAMe may be beneficial in
      the treatment of HCC.Significance: These findings explore the role of SNHG6
      lncRNA in suppressing production of the universal methyl donor SAMe and its
      impact on global DNA methylation levels in liver cancer and highlight the
      potential benefit of SAMe for the treatment of liver cancer. Cancer Res; 78(14);
      3849-64. (c)2018 AACR.

PMID- 29844128
TI  - Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol
      as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity.
AB  - Purpose: The DEAD-box RNA helicase eIF4A1 carries out the key enzymatic step of
      cap-dependent translation initiation and is a well-established target for cancer
      therapy, but no drug against it has entered evaluation in patients. We identified
      and characterized a natural compound with broad antitumor activities that emerged
      from the first target-based screen to identify novel eIF4A1
      inhibitors.Experimental Design: We tested potency and specificity of the marine
      compound elatol versus eIF4A1 ATPase activity. We also assessed eIF4A1 helicase
      inhibition, binding between the compound and the target including binding site
      mutagenesis, and extensive mechanistic studies in cells. Finally, we determined
      maximum tolerated dosing in vivo and assessed activity against xenografted
      tumors.Results: We found elatol is a specific inhibitor of ATP hydrolysis by
      eIF4A1 in vitro with broad activity against multiple tumor types. The compound
      inhibits eIF4A1 helicase activity and binds the target with unexpected 2:1
      stoichiometry at key sites in its helicase core. Sensitive tumor cells suffer
      acute loss of translationally regulated proteins, leading to growth arrest and
      apoptosis. In contrast to other eIF4A1 inhibitors, elatol induces markers of an
      integrated stress response, likely an off-target effect, but these effects do not
      mediate its cytotoxic activities. Elatol is less potent in vitro than the well
      studied eIF4A1 inhibitor silvestrol but is tolerated in vivo at approximately
      100* relative dosing, leading to significant activity against lymphoma
      xenografts.Conclusions: Elatol's identification as an eIF4A1 inhibitor with in
      vivo antitumor activities provides proof of principle for target-based screening
      against this highly promising target for cancer therapy. Clin Cancer Res; 24(17);
      4256-70. (c)2018 AACR.

PMID- 29844129
TI  - Phase Ib Study of Binimetinib with Paclitaxel in Patients with Platinum-Resistant
      Ovarian Cancer: Final Results, Potential Biomarkers, and Extreme Responders.
AB  - Purpose: Epithelial ovarian cancer (EOC) is a molecularly diverse disease. MEK
      inhibition targets tumors harboring MAPK pathway alterations and enhances
      paclitaxel-induced apoptosis in EOC. This phase Ib study evaluated the MEK
      inhibitor binimetinib combined with paclitaxel in patients with platinum
      resistant EOC.Patients and Methods: Patients received intravenous weekly
      paclitaxel with oral binimetinib in three different administration schedules.
      Outcomes were assessed by RECIST and CGIC CA-125 response criteria. Tumor samples
      were analyzed using next-generation sequencing.Results: Thirty-four patients
      received >=1 binimetinib dose. A 30-mg twice-a-day continuous or 45-mg twice-a
      day intermittent binimetinib dose was deemed the recommended phase II dose (RP2D)
      in combination with 80 mg/m2 i.v. weekly paclitaxel. Rate of grade 3/4 adverse
      events was 65%. The best overall response rate was 18%-one complete (CR) and four
      partial responses (PR)-among 28 patients with RECIST-measurable disease. Eleven
      patients achieved stable disease (SD), yielding a clinical benefit rate
      (CR+PR+SD) of 57%. Response rates, per both RECIST and CA-125 criteria, were
      highest in the 45-mg twice-a-day continuous cohort and lowest in the 45-mg twice
      a-day intermittent cohort. All four evaluable patients with MAPK pathway-altered
      tumors experienced clinical benefit.Conclusions: The combination of binimetinib
      and intravenous weekly paclitaxel was tolerable in this patient population. The
      RP2D of binimetinib in combination with paclitaxel was 30 mg twice a day as a
      continuous or 45 mg twice a day as an intermittent dose. Although response rates
      were modest, a higher clinical benefit rate was seen in patients harboring
      alterations affecting the MAPK pathway. Clin Cancer Res; 24(22); 5525-33. (c)2018
      AACR.

PMID- 29844130
TI  - Detection of Gastric Cancer with Novel Methylated DNA Markers: Discovery, Tissue
      Validation, and Pilot Testing in Plasma.
AB  - Purpose: Gastric adenocarcinoma is the third most common cause of cancer
      mortality worldwide. Accurate and affordable noninvasive detection methods have
      potential value for screening and surveillance. Herein, we identify novel
      methylated DNA markers (MDM) for gastric adenocarcinoma, validate their
      discrimination for gastric adenocarcinoma in tissues from geographically separate
      cohorts, explore marker acquisition through the oncogenic cascade, and describe
      distributions of candidate MDMs in plasma from gastric adenocarcinoma cases and
      normal controls.Experimental Design: Following discovery by unbiased whole
      methylome sequencing, candidate MDMs were validated by blinded methylation
      specific PCR in archival case-control tissues from U.S. and South Korean
      patients. Top MDMs were then assayed by an analytically sensitive method
      (quantitative real-time allele-specific target and signal amplification) in a
      blinded pilot study on archival plasma from gastric adenocarcinoma cases and
      normal controls.Results: Whole-methylome discovery yielded novel and highly
      discriminant candidate MDMs. In tissue, a panel of candidate MDMs detected
      gastric adenocarcinoma in 92% to 100% of U.S. and South Korean cohorts at 100%
      specificity. Levels of most MDMs increased progressively from normal mucosa
      through metaplasia, adenoma, and gastric adenocarcinoma with variation in points
      of greatest marker acquisition. In plasma, a 3-marker panel (ELMO1, ZNF569,
      C13orf18) detected 86% (95% CI, 71-95) of gastric adenocarcinomas at 95%
      specificity.Conclusions: Novel MDMs appear to accurately discriminate gastric
      adenocarcinoma from normal controls in both tissue and plasma. The point of
      aberrant methylation during oncogenesis varies by MDM, which may have relevance
      to marker selection in clinical applications. Further exploration of these MDMs
      for gastric adenocarcinoma screening and surveillance is warranted. Clin Cancer
      Res; 24(22); 5724-34. (c)2018 AACR.

PMID- 29844132
TI  - Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal
      Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan
      Synthesis.
AB  - Purpose: We aimed to discover glycosyltransferase gene (glycogene)-derived
      molecular subtypes of colorectal cancer associated with patient
      outcomes.Experimental Design: Transcriptomic and epigenomic datasets of nontumor,
      precancerous, cancerous tissues, and cell lines with somatic mutations, mismatch
      repair status, clinicopathologic and survival information were assembled (n =
      4,223) and glycogene profiles were analyzed. IHC for a glycogene, GALNT6, was
      conducted in adenoma and carcinoma specimens (n = 403). The functional role and
      cell surface glycan profiles were further investigated by in vitro loss-of
      function assays and lectin microarray analysis.Results: We initially developed
      and validated a 15-glycogene signature that can identify a poor-prognostic
      subtype, which closely related to deficient mismatch repair (dMMR) and GALNT6
      downregulation. The association of decreased GALNT6 with dMMR was confirmed in
      multiple datasets of tumors and cell lines, and was further recapitulated by IHC,
      where approximately 15% tumors exhibited loss of GALNT6 protein. GALNT6 mRNA and
      protein was expressed in premalignant/preinvasive lesions but was subsequently
      downregulated in a subset of carcinomas, possibly through epigenetic silencing.
      Decreased GALNT6 was independently associated with poor prognosis in the IHC
      cohort and an additional microarray meta-cohort, by multivariate analyses, and
      its discriminative power of survival was particularly remarkable in stage III
      patients. GALNT6 silencing in SW480 cells promoted invasion, migration,
      chemoresistance, and increased cell surface expression of a cancer-associated
      truncated O-glycan, Tn-antigen.Conclusions: The 15-glycogene signature and the
      expression levels of GALNT6 mRNA and protein each serve as a novel prognostic
      biomarker, highlighting the role of dysregulated glycogenes in cancer-associated
      glycan synthesis and poor prognosis. Clin Cancer Res; 24(18); 4468-81. (c)2018
      AACR.

PMID- 29844131
TI  - TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in
      PTEN and TP53-Mutated Prostate Cancer.
AB  - Purpose: Deletions or mutations in PTEN and TP53 tumor suppressor genes have been
      linked to lineage plasticity in therapy-resistant prostate cancer. Fusion-driven
      overexpression of the oncogenic transcription factor ERG is observed in
      approximately 50% of all prostate cancers, many of which also harbor PTEN and
      TP53 alterations. However, the role of ERG in lineage plasticity of PTEN/TP53
      altered tumors is unclear. Understanding the collective effect of multiple
      mutations within one tumor is essential to combat plasticity-driven therapy
      resistance.Experimental Design: We generated a Pten-negative/Trp53-mutated/ERG
      overexpressing mouse model of prostate cancer and integrated RNA-sequencing with
      ERG chromatin immunoprecipitation-sequencing (ChIP-seq) to identify pathways
      regulated by ERG in the context of Pten/Trp53 alteration. We investigated ERG
      dependent sensitivity to the antiandrogen enzalutamide and cyclin-dependent
      kinase 4 and 6 (CDK4/6) inhibitor palbociclib in human prostate cancer cell
      lines, xenografts, and allografted mouse tumors. Trends were evaluated in TCGA,
      SU2C, and Beltran 2016 published patient cohorts and a human tissue
      microarray.Results: Transgenic ERG expression in mice blocked Pten/Trp53
      alteration-induced decrease of AR expression and downstream luminal epithelial
      genes. ERG directly suppressed expression of cell cycle-related genes, which
      induced RB hypophosphorylation and repressed E2F1-mediated expression of
      mesenchymal lineage regulators, thereby restricting adenocarcinoma plasticity and
      maintaining antiandrogen sensitivity. In ERG-negative tumors, CDK4/6 inhibition
      delayed tumor growth.Conclusions: Our studies identify a previously undefined
      function of ERG to restrict lineage plasticity and maintain antiandrogen
      sensitivity in PTEN/TP53-altered prostate cancer. Our findings suggest ERG fusion
      as a biomarker to guide treatment of PTEN/TP53-altered, RB1-intact prostate
      cancer. Clin Cancer Res; 24(18); 4551-65. (c)2018 AACR.

PMID- 29844133
TI  - Loss of Elongation-Like Factor 1 Spontaneously Induces Diverse, RNase H-Related
      Suppressor Mutations in Schizosaccharomyces pombe.
AB  - A healthy individual may carry a detrimental genetic trait that is masked by
      another genetic mutation. Such suppressive genetic interactions, in which a
      mutant allele either partially or completely restores the fitness defect of a
      particular mutant, tend to occur between genes that have a confined functional
      connection. Here we investigate a self-recovery phenotype in Schizosaccharomyces
      pombe, mediated by suppressive genetic interactions that can be amplified during
      cell culture. Cells without Elf1, an AAA+ family ATPase, have severe growth
      defects initially, but quickly recover growth rates near to those of wild-type
      strains by acquiring suppressor mutations. elf1Delta cells accumulate RNAs within
      the nucleus and display effects of genome instability such as sensitivity to DNA
      damage, increased incidence of lagging chromosomes, and mini-chromosome loss.
      Notably, the rate of phenotypic recovery was further enhanced in elf1Delta cells
      when RNase H activities were abolished and significantly reduced upon
      overexpression of RNase H1, suggesting that loss of Elf1-related genome
      instability can be resolved by RNase H activities, likely through eliminating the
      potentially mutagenic DNA-RNA hybrids caused by RNA nuclear accumulation. Using
      whole genome sequencing, we mapped a few consistent suppressors of elf1Delta
      including mutated Cue2, Rpl2702, and SPBPJ4664.02, suggesting previously unknown
      functional connections between Elf1 and these proteins. Our findings describe a
      mechanism by which cells bearing mutations that cause fitness defects and genome
      instability may accelerate the fitness recovery of their population through
      quickly acquiring suppressors. We propose that this mechanism may be universally
      applicable to all microorganisms in large-population cultures.

PMID- 29844135
TI  - Identifying opportunities to advance practice at a large academic medical center
      using the ASHP Ambulatory Care Self-Assessment Tool.
AB  - PURPOSE: The use of the ASHP Ambulatory Care Self-Assessment Tool to advance
      pharmacy practice at 8 ambulatory care clinics of a large academic medical center
      is described. SUMMARY: The ASHP Ambulatory Care Self-Assessment Tool was
      developed to help ambulatory care pharmacists assess how their current practices
      align with the ASHP Practice Advancement Initiative. The Henry Ford Hospital
      Ambulatory Care Advisory Group (ACAG) opted to use the "Practitioner Track"
      sections of the tool to assess pharmacy practices within each of 8 ambulatory
      care clinics individually. The responses to self-assessment items were then
      compiled and discussed by ACAG members. The group identified best practices and
      ways to implement action items to advance ambulatory care practice throughout the
      institution. Three recommended action items were common to most clinics: (1)
      identify and evaluate solutions to deliver financially viable services, (2)
      develop technology to improve patient care, and (3) optimize the role of pharmacy
      technicians and support personnel. The ACAG leadership met with pharmacy
      administrators to discuss how action items that were both feasible and deemed
      likely to have a medium-to-high impact aligned with departmental goals and used
      this information to develop an ambulatory care strategic plan. This process
      informed and enabled initiatives to advance ambulatory care pharmacy practice
      within the system. CONCLUSION: The ASHP Ambulatory Care Self-Assessment Tool was
      useful in identifying opportunities for practice advancement in a large academic
      medical center.

PMID- 29844134
TI  - The Effect of Strong Purifying Selection on Genetic Diversity.
AB  - Purifying selection reduces genetic diversity, both at sites under direct
      selection and at linked neutral sites. This process, known as background
      selection, is thought to play an important role in shaping genomic diversity in
      natural populations. Yet despite its importance, the effects of background
      selection are not fully understood. Previous theoretical analyses of this process
      have taken a backward-time approach based on the structured coalescent. While
      they provide some insight, these methods are either limited to very small samples
      or are computationally prohibitive. Here, we present a new forward-time analysis
      of the trajectories of both neutral and deleterious mutations at a nonrecombining
      locus. We find that strong purifying selection leads to remarkably rich dynamics:
      neutral mutations can exhibit sweep-like behavior, and deleterious mutations can
      reach substantial frequencies even when they are guaranteed to eventually go
      extinct. Our analysis of these dynamics allows us to calculate analytical
      expressions for the full site frequency spectrum. We find that whenever
      background selection is strong enough to lead to a reduction in genetic
      diversity, it also results in substantial distortions to the site frequency
      spectrum, which can mimic the effects of population expansions or positive
      selection. Because these distortions are most pronounced in the low and high
      frequency ends of the spectrum, they become particularly important in larger
      samples, but may have small effects in smaller samples. We also apply our forward
      time framework to calculate other quantities, such as the ultimate fates of
      polymorphisms or the fitnesses of their ancestral backgrounds.

PMID- 29844137
TI  - The Cycle of Child Protection Services Involvement: A Cohort Study of Adolescent
      Mothers.
AB  - OBJECTIVES: To determine if adolescent mothers who were in the care of child
      protection services (CPS) when they gave birth to their first child are more
      likely to have that child taken into CPS care before the child's second birthday
      than adolescent mothers who were not in the care of CPS. METHODS: Linkable
      administrative data were used to create a population-based cohort of adolescent
      mothers whose first child was born in Manitoba, Canada between April 1, 1998, and
      March 31, 2013 (n = 5942). Adjusted odds ratios (aOR) of having that first child
      taken into care before their second birthday were compared between mothers who
      were in care (n = 576) and mothers who were not in care (n = 5366) at the birth
      of their child by using logistic regression models. RESULTS: Adolescent mothers
      who were in care had greater odds of having their child taken into care before
      the child's second birthday (aOR = 7.53; 95% confidence interval [CI] = 6.19
      9.14). Specifically, their children had higher odds of being taken into care in
      their first week of life (aOR = 11.64; 95% CI = 8.83-15.34), between 1 week and
      their first birthday (aOR = 3.63; 95% CI = 2.79-4.71), and between their first
      and second birthday (aOR = 2.21; 95% CIl = 1.53-3.19). CONCLUSIONS: Findings
      support an intergenerational cycle of involvement with CPS. More and better
      services are required for adolescent mothers who give birth while in care of CPS.

PMID- 29844136
TI  - A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channel.
AB  - The adenosine triphosphate (ATP)-sensitive (KATP) channels in pancreatic beta
      cells couple the blood glucose level to insulin secretion. KATP channels in
      pancreatic beta cells comprise the pore-forming Kir6.2 and the modulatory
      sulfonylurea receptor 1 (SUR1) subunits. Currently, there is no high-affinity and
      relatively specific inhibitor for the Kir6.2 pore. The importance of developing
      such inhibitors is twofold. First, in many cases, the lack of such an inhibitor
      precludes an unambiguous determination of the Kir6.2's role in certain
      physiological and pathological processes. This problem is exacerbated because
      Kir6.2 knockout mice do not yield the expected phenotypes of hyperinsulinemia and
      hypoglycemia, which in part, may reflect developmental adaptation. Second,
      mutations in Kir6.2 or SUR1 that increase the KATP current cause permanent
      neonatal diabetes mellitus (PNDM). Many patients who have PNDM have been
      successfully treated with sulphonylureas, a common class of antidiabetic drugs
      that bind to SUR1 and indirectly inhibit Kir6.2, thereby promoting insulin
      secretion. However, some PNDM-causing mutations render KATP channels insensitive
      to sulphonylureas. Conceptually, because these mutations are located
      intracellularly, an inhibitor blocking the Kir6.2 pore from the extracellular
      side might provide another approach to this problem. Here, by screening the
      venoms from >200 animals against human Kir6.2 coexpressed with SUR1, we
      discovered a small protein of 54 residues (SpTx-1) that inhibits the KATP channel
      from the extracellular side. It inhibits the channel with a dissociation constant
      value of 15 nM in a relatively specific manner and with an apparent one-to-one
      stoichiometry. SpTx-1 evidently inhibits the channel by primarily targeting
      Kir6.2 rather than SUR1; it inhibits not only wild-type Kir6.2 coexpressed with
      SUR1 but also a Kir6.2 mutant expressed without SUR1. Importantly, SpTx-1
      suppresses both sulfonylurea-sensitive and -insensitive, PNDM-causing Kir6.2
      mutants. Thus, it will be a valuable tool to investigate the channel's
      physiological and biophysical properties and to test a new strategy for treating
      sulfonylurea-resistant PNDM.

PMID- 29844138
TI  - Understanding the Intergenerational Cycle of Child Protective Service
      Involvement.

PMID- 29844139
TI  - Safety of Oral Propranolol for Infantile Hemangioma.
AB  - OBJECTIVES: The safety of oral propranolol for infantile hemangioma has not yet
      been studied at population level since the pediatric use marketing authorization
      was obtained in Europe. METHODS: A survey of a nationwide, claim-based
      observational cohort of children <3 years old, with at least 1 delivery of oral
      propranolol between July 2014 and June 2016, was performed by using the database
      of the French National Health Insurance system. Standardized morbidity ratios
      (SMRs) were calculated by using, from the same database, a representative random
      sample of nonexposed subjects. The main outcomes were hospitalizations for
      cardiovascular (conduction disorders, bradycardia, and hypotension), respiratory
      (bronchial hyperactivity and bronchospasm), or metabolic events (hypoglycemia and
      hyperkalaemia), identified through the hospitalization diagnostic codes of the
      International Classification of Diseases, 10th Revision. The main analysis was
      conducted separately on "healthy" children (N = 1484), that is, free from of any
      prespecified underlying disease and on children with 1 of these underlying
      diseases (N = 269). RESULTS: In all, 1753 patients <3 years of age had at least 2
      deliveries of oral propranolol. In the healthy population, we observed 2
      cardiovascular events (SMR = 2.8 [0-6.7]), 51 respiratory events (SMR = 1.7 [1.2
      2.1]), and 3 metabolic events (SMR = 5.1 [0-10.9]). In the population with an
      underlying disease (mainly congenital heart disease), we observed 11
      cardiovascular events leading to an SMR of 6.0 (2.5-9.6). SMRs were not
      significantly raised for respiratory or metabolic events in this "nonhealthy"
      population. CONCLUSIONS: In this study on a large continuous nationwide claims
      database, we confirm the safety profile of oral propranolol in healthy children
      to be good.

PMID- 29844140
TI  - Fabrication of a Corneal Model Composed of Corneal Epithelial and Endothelial
      Cells via a Collagen Vitrigel Membrane Functioned as an Acellular Stroma and Its
      Application to the Corneal Permeability Test of Chemicals.
AB  - A collagen vitrigel membrane (CVM) we developed can function as both a scaffold
      for cells and a pathway for chemicals. To extrapolate the corneal permeability of
      chemicals in vivo, we proposed six corneal models using the CVM. Thin and thick
      CVMs were used as models for Bowman's membrane (BM) and an acellular stroma (AS),
      respectively. Models for a corneal epithelium (CEpi), a CEpi-AS, a CEpi
      endothelium (Endo), and a CEpi-AS-Endo were fabricated by culturing corneal
      epithelial cells and/or corneal endothelial cells on the surface of CVMs.
      Subsequently, the permeability coefficient (Papp) value of each model was
      calculated using five chemicals with different molecular radii; cyanocobalamin
      and four fluorescein isothiocyanate-dextrans (FD) (FD-4, FD-10, FD-20, and FD
      40). The slopes of Papp versus molecular radii of those chemicals in the both BM
      and AS models were almost similar to data using an excised rabbit corneal stroma.
      The ratios of Papp values in models for BM, CEpi, and CEpi-Endo against those in
      data using an excised rabbit cornea were calculated as 75.4-fold, 6.4-fold, and
      4.5-fold for FD-4, and 38.7-fold, 10.0-fold, and 4.2-fold for FD-10,
      respectively. Similarly, those in models for AS, CEpi-AS, and CEpi-AS-Endo were
      calculated as 26.1-fold, 2.5-fold, and 0.6-fold for FD-4, and 26.1-fold, 1.5
      fold, and 0.6-fold for FD-10, respectively. These results suggest that the CEpi
      AS-Endo model with both the barrier function of corneal cell layers and the
      diffusion capacity of chemicals in thick CVM is most appropriate for
      extrapolating the corneal permeability of chemicals in vivo.

PMID- 29844141
TI  - Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine:
      A Scientific Statement From the American Heart Association.
AB  - The completion of the Human Genome Project has unleashed a wealth of human
      genomics information, but it remains unclear how best to implement this
      information for the benefit of patients. The standard approach of biomedical
      research, with researchers pursuing advances in knowledge in the laboratory and,
      separately, clinicians translating research findings into the clinic as much as
      decades later, will need to give way to new interdisciplinary models for research
      in genomic medicine. These models should include scientists and clinicians
      actively working as teams to study patients and populations recruited in clinical
      settings and communities to make genomics discoveries-through the combined
      efforts of data scientists, clinical researchers, epidemiologists, and basic
      scientists-and to rapidly apply these discoveries in the clinic for the
      prediction, prevention, diagnosis, prognosis, and treatment of cardiovascular
      diseases and stroke. The highly publicized US Precision Medicine Initiative, also
      known as All of Us, is a large-scale program funded by the US National Institutes
      of Health that will energize these efforts, but several ongoing studies such as
      the UK Biobank Initiative; the Million Veteran Program; the Electronic Medical
      Records and Genomics Network; the Kaiser Permanente Research Program on Genes,
      Environment and Health; and the DiscovEHR collaboration are already providing
      exemplary models of this kind of interdisciplinary work. In this statement, we
      outline the opportunities and challenges in broadly implementing new
      interdisciplinary models in academic medical centers and community settings and
      bringing the promise of genomics to fruition.

PMID- 29844142
TI  - Guidance is needed on valproate in pregnancy for those without capacity.

PMID- 29844143
TI  - Dynamic Regulation of Cerebral Blood Flow in Patients With Alzheimer Disease.
AB  - Cerebral autoregulation and baroreflex sensitivity are key mechanisms that
      maintain cerebral blood flow. This study assessed whether these control
      mechanisms are affected in patients with dementia and mild cognitive impairment
      due to Alzheimer disease, as this would increase the risks of antihypertensive
      treatment. We studied 53 patients with dementia (73.1 years [95% confidence
      interval (CI), 71.4-74.8]), 37 patients with mild cognitive impairment (69.2
      years [95% CI, 66.4-72.0]), and 47 controls (69.4 years [95% CI, 68.3-70.5]).
      Beat-to-beat blood pressure (photoplethysmography), heart rate, and cerebral
      blood flow velocity (transcranial Doppler) were measured during 5-minute rest
      (sitting) and 5 minutes of orthostatic challenges, using repeated sit-to-stand
      maneuvers. Cerebral autoregulation was assessed using transfer function analysis
      and the autoregulatory index. Baroreflex sensitivity was estimated with transfer
      function analysis and by calculating the heart rate response to blood pressure
      changes during the orthostatic challenges. Dementia patients had the lowest
      cerebral blood flow velocity (P=0.004). During rest, neither transfer function
      analysis nor the autoregulatory index indicated impairments in cerebral
      autoregulation. During the orthostatic challenges, higher autoregulatory index
      (P=0.011) and lower transfer function gain (P=0.017), indicating better cerebral
      autoregulation, were found in dementia (4.56 arb. unit [95% CI, 4.14-4.97]; 0.59
      cm/s per mm Hg [95% CI, 0.51-0.66]) and mild cognitive impairment (4.59 arb. unit
      [95% CI, 4.04-5.13]; 0.51 cm/s per mm Hg [95% CI, 0.44-0.59]) compared with
      controls (3.71 arb. unit [95% CI, 3.35-4.07]; 0.67 cm/s per mm Hg [95% CI, 0.59
      0.74]). Baroreflex sensitivity measures did not differ between groups. In
      conclusion, the key mechanisms to control blood pressure and cerebral blood flow
      are not reduced in 2 stages of Alzheimer disease compared with controls, both in
      rest and during orthostatic changes that reflect daily life challenges.

PMID- 29844144
TI  - Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and
      Endoplasmic Reticulum Stress Response in Hypertension.
AB  - Vascular Nox (NADPH oxidase)-derived reactive oxygen species and endoplasmic
      reticulum (ER) stress have been implicated in hypertension. However,
      relationships between these processes are unclear. We hypothesized that Nox
      isoforms localize in a subcellular compartment-specific manner, contributing to
      oxidative and ER stress, which influence the oxidative proteome and vascular
      function in hypertension. Nox compartmentalization (cell fractionation), O2-
      (lucigenin), H2O2 (amplex red), reversible protein oxidation (sulfenylation),
      irreversible protein oxidation (protein tyrosine phosphatase, peroxiredoxin
      oxidation), and ER stress (PERK [protein kinase RNA-like endoplasmic reticulum
      kinase], IRE1alpha [inositol-requiring enzyme 1], and phosphorylation/oxidation)
      were studied in spontaneously hypertensive rat (SHR) vascular smooth muscle cells
      (VSMCs). VSMC proliferation was measured by fluorescence-activated cell sorting,
      and vascular reactivity assessed in stroke-prone SHR arteries by myography. Noxs
      were downregulated by short interfering RNA and pharmacologically. In SHR, Noxs
      were localized in specific subcellular regions: Nox1 in plasma membrane and Nox4
      in ER. In SHR, oxidative stress was associated with increased protein
      sulfenylation and hyperoxidation of protein tyrosine phosphatases and
      peroxiredoxins. Inhibition of Nox1 (NoxA1ds), Nox1/4 (GKT137831), and ER stress
      (4-phenylbutyric acid/tauroursodeoxycholic acid) normalized SHR vascular reactive
      oxygen species generation. GKT137831 reduced IRE1alpha sulfenylation and XBP1 (X
      box binding protein 1) splicing in SHR. Increased VSMC proliferation in SHR was
      normalized by GKT137831, 4-phenylbutyric acid, and STF083010 (IRE1-XBP1
      disruptor). Hypercontractility in the stroke-prone SHR was attenuated by 4
      phenylbutyric acid. We demonstrate that protein hyperoxidation in hypertension is
      associated with oxidative and ER stress through upregulation of plasmalemmal-Nox1
      and ER-Nox4. The IRE1-XBP1 pathway of the ER stress response is regulated by
      Nox4/reactive oxygen species and plays a role in the hyperproliferative VSMC
      phenotype in SHR. Our study highlights the importance of Nox subcellular
      compartmentalization and interplay between cytoplasmic reactive oxygen species
      and ER stress response, which contribute to the VSMC oxidative proteome and
      vascular dysfunction in hypertension.

PMID- 29844145
TI  - Modeling Superimposed Preeclampsia Using Ang II (Angiotensin II) Infusion in
      Pregnant Stroke-Prone Spontaneously Hypertensive Rats.
AB  - Hypertensive disorders of pregnancy are the second leading cause of maternal
      deaths worldwide. Superimposed preeclampsia is an increasingly common problem and
      often associated with impaired placental perfusion. Understanding the underlying
      mechanisms and developing treatment options are crucial. The pregnant stroke
      prone spontaneously hypertensive rat has impaired uteroplacental blood flow and
      abnormal uterine artery remodeling. We used Ang II (angiotensin II) infusion in
      pregnant stroke-prone spontaneously hypertensive rats to mimic the increased
      cardiovascular stress associated with superimposed preeclampsia and examine the
      impact on the maternal cardiovascular system and fetal development. Continuous
      infusion of Ang II at 500 or 1000 ng/kg per minute was administered from
      gestational day 10.5 until term. Radiotelemetry and echocardiography were used to
      monitor hemodynamic and cardiovascular changes, and urine was collected
      prepregnancy and throughout gestation. Uterine artery myography assessed
      uteroplacental vascular function and structure. Fetal measurements were made at
      gestational day 18.5, and placentas were collected for histological and gene
      expression analyses. The 1000 ng/kg per minute Ang II treatment significantly
      increased blood pressure (P<0.01), reduced cardiac output (P<0.05), and reduced
      diameter and increased stiffness of the uterine arteries (P<0.01) during
      pregnancy. The albumin:creatinine ratio was increased in both Ang II treatment
      groups (P<0.05; P<0.0001). The 1000 ng/kg per minute-treated fetuses were
      significantly smaller than vehicle treatment (P<0.001). Placental expression of
      Ang II receptors was increased in the junctional zone in 1000 ng/kg per minute
      Ang II-treated groups (P<0.05), with this zone showing depletion of glycogen
      content and structural abnormalities. Ang II infusion in pregnant stroke-prone
      spontaneously hypertensive rats mirrors hemodynamic, cardiac, and urinary
      profiles observed in preeclamptic women, with evidence of impaired fetal growth.

PMID- 29844146
TI  - Activin A and Late Postpartum Cardiac Dysfunction Among Women With Hypertensive
      Disorders of Pregnancy.
AB  - Women with hypertensive disorders of pregnancy have an increased risk of
      subsequent heart failure and cardiovascular disease when compared with women with
      normotensive pregnancies. Although the mechanisms underlying these findings are
      unclear, elevated levels of the biomarker activin A are associated with
      myocardial dysfunction and may have predictive value. We hypothesized that
      elevated levels of antepartum activin A levels would correlate with postpartum
      cardiac dysfunction in women with hypertensive disorders of pregnancy. We
      prospectively studied 85 women to determine whether increased antepartum activin
      A levels were associated with cardiac dysfunction at 1 year postpartum as
      measured by global longitudinal strain. Thirty-two patients were diagnosed with
      preeclampsia, 28 were diagnosed with gestational or chronic hypertension, and the
      remainder were nonhypertensive controls. Activin A levels were measured with
      ELISA both in the third antepartum trimester and at 1 year postpartum.
      Comprehensive echocardiograms including measurement of global longitudinal strain
      were also performed at enrollment and at 1 year postpartum. Antepartum activin A
      levels correlated with worsening antepartum global longitudinal strain (r=0.70;
      P=0.0001). Across the entire cohort, elevated antepartum activin A levels were
      associated with the development of abnormal global longitudinal strain at 1 year
      (C statistic 0.74; P=0.004). This association remained significant after
      multivariable adjustment for clinically relevant confounders (C statistic 0.93;
      P=0.01). Postpartum activin A levels also correlated with increasing left
      ventricular mass index (P=0.02), increasing mean arterial pressures (P=0.02), and
      decreasing E' values (P=0.01). Activin A may be a useful tool for identifying and
      monitoring patients at risk for postpartum development of cardiovascular disease.

PMID- 29844147
TI  - Stay in Shape With BH4: Loss of Endothelial Tetrahydrobiopterin Promotes Aortic
      Aneurysm Development in Mice.

PMID- 29844148
TI  - Blood Pressure and Cerebral Blood Flow in Alzheimer Disease.

PMID- 29844149
TI  - When Guideline Authors Ignore Their Own Guidelines.

PMID- 29844150
TI  - To Be, or Nox to Be, Endoplasmic Reticulum Stress in Hypertension.

PMID- 29844151
TI  - Cerebrospinal Fluid Protein Changes in Preeclampsia.
AB  - The molecular mechanisms underlying seizure susceptibility in preeclampsia are
      unknown. We hypothesized that altered expression of distinct proteins in the
      cerebrospinal fluid (CSF) may reflect pathophysiological changes in the central
      nervous system that contribute to the neurological manifestations of severe
      preeclampsia. We obtained CSF samples from 13 patients with preeclampsia and 14
      control patients during spinal anesthesia before delivery and analyzed them by
      SOMAscan, an aptamer-based proteomics platform for alterations in 1310 protein
      levels. Ingenuity Pathway Analysis was conducted to highlight relationships
      between preeclampsia-specific proteins found to be significantly altered. For 2
      of the target proteins, we validated the difference in CSF concentrations by
      ELISA. SOMAscan revealed 82 proteins, whose expression levels were significantly
      different (P<0.05) in CSF from patients with preeclampsia versus controls.
      Principal component analysis achieved perfect separation of the preeclampsia and
      control groups in 2 dimensions. The differentially expressed proteins converge
      around 4 signaling molecules: TGF-beta (transforming growth factor-beta), VEGFA
      (vascular endothelial growth factor A), angiotensinogen, and IL-6 (interleukin
      6). Within the TGF-beta pathway, upregulation of activin A (301.6+/-47.4 versus
      151.6+/-20.5 pg/mL; P=0.0074) and follistatin-related gene (5129+/-347 versus
      3016+/-188 pg/mL; P<0.0001) in preeclampsia was confirmed by ELISA. In summary,
      signaling pathways important for vascular remodeling, inflammation, and neuronal
      growth, signaling, and electrophysiology were well represented among the proteins
      found to be altered in CSF in patients with preeclampsia.

PMID- 29844153
TI  - Preeclampsia: What Does the Brain Tell Us? Can We Blame the Eclampsia Risk on a
      Malperfused Placenta?

PMID- 29844152
TI  - Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin)
      II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.
AB  - GTPCH (GTP cyclohydrolase 1, encoded by Gch1) is required for the synthesis of
      tetrahydrobiopterin; a critical regulator of endothelial NO synthase function. We
      have previously shown that mice with selective loss of Gch1 in endothelial cells
      have mild vascular dysfunction, but the consequences of endothelial cell
      tetrahydrobiopterin deficiency in vascular disease pathogenesis are unknown. We
      investigated the pathological consequence of Ang (angiotensin) II infusion in
      endothelial cell Gch1 deficient (Gch1fl/fl Tie2cre) mice. Ang II (0.4 mg/kg per
      day, delivered by osmotic minipump) caused a significant decrease in circulating
      tetrahydrobiopterin levels in Gch1fl/fl Tie2cre mice and a significant increase
      in the Nomega-nitro-L-arginine methyl ester inhabitable production of H2O2 in the
      aorta. Chronic treatment with this subpressor dose of Ang II resulted in a
      significant increase in blood pressure only in Gch1fl/fl Tie2cre mice. This
      finding was mirrored with acute administration of Ang II, where increased
      sensitivity to Ang II was observed at both pressor and subpressor doses. Chronic
      Ang II infusion in Gch1fl/fl Tie2ce mice resulted in vascular dysfunction in
      resistance mesenteric arteries with an enhanced constrictor and decreased dilator
      response and medial hypertrophy. Altered vascular remodeling was also observed in
      the aorta with an increase in the incidence of abdominal aortic aneurysm
      formation in Gch1fl/fl Tie2ce mice. These findings indicate a specific
      requirement for endothelial cell tetrahydrobiopterin in modulating the
      hemodynamic and structural changes induced by Ang II, through modulation of blood
      pressure, structural changes in resistance vessels, and aneurysm formation in the
      aorta.

PMID- 29844154
TI  - Prescribing in pregnancy shows the weaknesses in pharmacovigilance.

PMID- 29844155
TI  - QnAs with Joanne Chory.

PMID- 29844156
TI  - TAp73 contributes to the oxidative stress response by regulating protein
      synthesis.
AB  - TAp73 is a transcription factor that plays key roles in brain development, aging,
      and cancer. At the cellular level, TAp73 is a critical homeostasis-maintaining
      factor, particularly following oxidative stress. Although major studies focused
      on TAp73 transcriptional activities have indicated a contribution of TAp73 to
      cellular metabolism, the mechanisms underlying its role in redox homeostasis have
      not been completely elucidated. Here we show that TAp73 contributes to the
      oxidative stress response by participating in the control of protein synthesis.
      Regulation of mRNA translation occupies a central position in cellular
      homeostasis during the stress response, often by reducing global rates of protein
      synthesis and promoting translation of specific mRNAs. TAp73 depletion results in
      aberrant ribosomal RNA (rRNA) processing and impaired protein synthesis. In
      particular, polysomal profiles show that TAp73 promotes the integration of mRNAs
      that encode rRNA-processing factors in polysomes, supporting their translation.
      Concurrently, TAp73 depletion causes increased sensitivity to oxidative stress
      that correlates with reduced ATP levels, hyperactivation of AMPK, and
      translational defects. TAp73 is important for maintaining active translation of
      mitochondrial transcripts in response to oxidative stress, thus promoting
      mitochondrial activity. Our results indicate that TAp73 contributes to redox
      homeostasis by affecting the translational machinery, facilitating the
      translation of specific mitochondrial transcripts. This study identifies a
      mechanism by which TAp73 contributes to the oxidative stress response and
      describes a completely unexpected role for TAp73 in regulating protein synthesis.

PMID- 29844157
TI  - Genome-wide regulation of light-controlled seedling morphogenesis by three
      families of transcription factors.
AB  - Three families of transcription factors have been reported to play key roles in
      light control of Arabidopsis seedling morphogenesis. Among them, bHLH protein
      PIFs and plant-specific protein EIN3/EIN3-LIKE 1 (EIN3/EIL1) accumulate in the
      dark to maintain skotomorphogenesis. On the other hand, HY5 and HY5 HOMOLOG
      (HYH), two related bZIP proteins, are stabilized in light and promote
      photomorphogenic development. To systemically investigate the transcriptional
      regulation of light-controlled seedling morphogenesis, we generated
      HY5ox/pifQein3eil1, which contained mutations of EIN3/EIL1 and four PIF genes
      (pifQein3eil1) and overexpression of HY5 Our results show that dark-grown
      HY5ox/pifQein3eil1 seedlings display a photomorphogenesis highly similar to that
      of wild-type seedlings grown in continuous light, with remarkably enhanced
      photomorphogenic phenotypes compared with the pifQ mutants. Consistent with the
      genetic evidence, transcriptome analysis indicated that PIFs, EIN3/EIL1, and HY5
      are dominant transcription factors in collectively mediating a wide range of
      light-caused genome-wide transcriptional changes. Moreover, PIFs and EIN3/EIL1
      independently control the expression of light-regulated genes such as HLS1 to
      cooperatively regulate apical hook formation, hypocotyl elongation, and cotyledon
      opening and expansion. This study illustrates a comprehensive regulatory network
      of transcription activities that correspond to specific morphological aspects in
      seedling skotomorphogenesis and photomorphogenesis.

PMID- 29844159
TI  - Mediator subunit MED31 is required for radial patterning of Arabidopsis roots.
AB  - Stem cell specification in multicellular organisms relies on the precise
      spatiotemporal control of RNA polymerase II (Pol II)-dependent gene
      transcription, in which the evolutionarily conserved Mediator coactivator complex
      plays an essential role. In Arabidopsis thaliana, SHORTROOT (SHR) and SCARECROW
      (SCR) orchestrate a transcriptional program that determines the fate and
      asymmetrical divisions of stem cells generating the root ground tissue. The
      mechanism by which SHR/SCR relays context-specific regulatory signals to the Pol
      II general transcription machinery is unknown. Here, we report the role of
      Mediator in controlling the spatiotemporal transcriptional output of SHR/SCR
      during asymmetrical division of stem cells and ground tissue patterning. The
      Mediator subunit MED31 interacted with SCR but not SHR. Reduction of MED31
      disrupted the spatiotemporal activation of CYCLIND6;1 (CYCD6;1), leading to
      defective asymmetrical division of stem cells generating ground tissue. MED31 was
      recruited to the promoter of CYCD6;1 in an SCR-dependent manner. MED31 was
      involved in the formation of a dynamic MED31/SCR/SHR ternary complex through the
      interface protein SCR. We demonstrate that the relative protein abundance of
      MED31 and SHR in different cell types regulates the dynamic formation of the
      ternary complex, which provides a tunable switch to strictly control the
      spatiotemporal transcriptional output. This study provides valuable clues to
      understand the mechanism by which master transcriptional regulators control organ
      patterning.

PMID- 29844158
TI  - Protein kinase Calpha gain-of-function variant in Alzheimer's disease displays
      enhanced catalysis by a mechanism that evades down-regulation.
AB  - Conventional protein kinase C (PKC) family members are reversibly activated by
      binding to the second messengers Ca2+ and diacylglycerol, events that break
      autoinhibitory constraints to allow the enzyme to adopt an active, but
      degradation-sensitive, conformation. Perturbing these autoinhibitory constraints,
      resulting in protein destabilization, is one of many mechanisms by which PKC
      function is lost in cancer. Here, we address how a gain-of-function germline
      mutation in PKCalpha in Alzheimer's disease (AD) enhances signaling without
      increasing vulnerability to down-regulation. Biochemical analyses of purified
      protein demonstrate that this mutation results in an ~30% increase in the
      catalytic rate of the activated enzyme, with no changes in the concentrations of
      Ca2+ or lipid required for half-maximal activation. Molecular dynamics
      simulations reveal that this mutation has both localized and allosteric effects,
      most notably decreasing the dynamics of the C-helix, a key determinant in the
      catalytic turnover of kinases. Consistent with this mutation not altering
      autoinhibitory constraints, live-cell imaging studies reveal that the basal
      signaling output of PKCalpha-M489V is unchanged. However, the mutant enzyme in
      cells displays increased sensitivity to an inhibitor that is ineffective toward
      scaffolded PKC, suggesting the altered dynamics of the kinase domain may
      influence protein interactions. Finally, we show that phosphorylation of a key
      PKC substrate, myristoylated alanine-rich C-kinase substrate, is increased in
      brains of CRISPR-Cas9 genome-edited mice containing the PKCalpha-M489V mutation.
      Our results unveil how an AD-associated mutation in PKCalpha permits enhanced
      agonist-dependent signaling via a mechanism that evades the cell's homeostatic
      down-regulation of constitutively active PKCalpha.

PMID- 29844160
TI  - Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2
      inhibitors.
AB  - Malaria control is threatened by a limited pipeline of effective pharmaceuticals
      against drug-resistant strains of Plasmodium falciparum Components of the
      mitochondrial electron transport chain (ETC) are attractive targets for drug
      development, owing to exploitable differences between the parasite and human ETC.
      Disruption of ETC function interferes with metabolic processes including de novo
      pyrimidine synthesis, essential for nucleic acid replication. We investigated the
      effects of ETC inhibitor selection on two distinct P. falciparum clones, Dd2 and
      106/1. Compounds CK-2-68 and RYL-552, substituted quinolones reported to block P.
      falciparum NADH dehydrogenase 2 (PfNDH2; a type II NADH:quinone oxidoreductase),
      unexpectedly selected mutations at the quinol oxidation (Qo) pocket of P.
      falciparum cytochrome B (PfCytB). Selection experiments with atovaquone (ATQ) on
      106/1 parasites yielded highly resistant PfCytB Y268S mutants seen in clinical
      infections that fail ATQ-proguanil treatment. In contrast, ATQ pressure on Dd2
      yielded moderately resistant parasites carrying a PfCytB M133I or K272R mutation.
      Strikingly, all ATQ-selected mutants demonstrated little change or slight
      increase of sensitivity to CK-2-68 or RYL-552. Molecular docking studies
      demonstrated binding of all three ETC inhibitors to the Qo pocket of PfCytB,
      where Y268 forms strong van der Waals interactions with the hydroxynaphthoquinone
      ring of ATQ but not the quinolone ring of CK-2-68 or RYL-552. Our results suggest
      that combinations of suitable ETC inhibitors may be able to subvert or delay the
      development of P. falciparum drug resistance.

PMID- 29844161
TI  - Exceptionally high levels of lead pollution in the Balkans from the Early Bronze
      Age to the Industrial Revolution.
AB  - The Balkans are considered the birthplace of mineral resource exploitation and
      metalworking in Europe. However, since knowledge of the timing and extent of
      metallurgy in southeastern Europe is largely constrained by discontinuous
      archaeological findings, the long-term environmental impact of past mineral
      resource exploitation is not fully understood. Here, we present a high-resolution
      and continuous geochemical record from a peat bog in western Serbia, providing a
      clear indication of the extent and magnitude of environmental pollution in this
      region, and a context in which to place archaeological findings. We observe
      initial evidence of anthropogenic lead (Pb) pollution during the earliest part of
      the Bronze Age [~3,600 years before Common Era (BCE)], the earliest such evidence
      documented in European environmental records. A steady, almost linear increase in
      Pb concentration after 600 BCE, until ~1,600 CE is observed, documenting the
      development in both sophistication and extent of southeastern European
      metallurgical activity throughout Antiquity and the medieval period. This
      provides an alternative view on the history of mineral exploitation in Europe,
      with metal-related pollution not ceasing at the fall of the western Roman Empire,
      as was the case in western Europe. Further comparison with other Pb pollution
      records indicates the amount of Pb deposited in the Balkans during the medieval
      period was, if not greater, at least similar to records located close to western
      European mining regions, suggestive of the key role the Balkans have played in
      mineral resource exploitation in Europe over the last 5,600 years.

PMID- 29844162
TI  - NT3-chitosan enables de novo regeneration and functional recovery in monkeys
      after spinal cord injury.
AB  - Spinal cord injury (SCI) often leads to permanent loss of motor, sensory, and
      autonomic functions. We have previously shown that neurotrophin3 (NT3)-loaded
      chitosan biodegradable material allowed for prolonged slow release of NT3 for 14
      weeks under physiological conditions. Here we report that NT3-loaded chitosan,
      when inserted into a 1-cm gap of hemisectioned and excised adult rhesus monkey
      thoracic spinal cord, elicited robust axonal regeneration. Labeling of cortical
      motor neurons indicated motor axons in the corticospinal tract not only entered
      the injury site within the biomaterial but also grew across the 1-cm-long lesion
      area and into the distal spinal cord. Through a combination of magnetic resonance
      diffusion tensor imaging, functional MRI, electrophysiology, and kinematics-based
      quantitative walking behavioral analyses, we demonstrated that NT3-chitosan
      enabled robust neural regeneration accompanied by motor and sensory functional
      recovery. Given that monkeys and humans share similar genetics and physiology,
      our method is likely translatable to human SCI repair.

PMID- 29844164
TI  - QnAs with Caroline Dean.

PMID- 29844163
TI  - Doc2-mediated superpriming supports synaptic augmentation.
AB  - Various forms of synaptic plasticity underlie aspects of learning and memory.
      Synaptic augmentation is a form of short-term plasticity characterized by
      synaptic enhancement that persists for seconds following specific patterns of
      stimulation. The mechanisms underlying this form of plasticity are unclear but
      are thought to involve residual presynaptic Ca2+ Here, we report that
      augmentation was reduced in cultured mouse hippocampal neurons lacking the Ca2+
      sensor, Doc2; other forms of short-term enhancement were unaffected. Doc2 binds
      Ca2+ and munc13 and translocates to the plasma membrane to drive augmentation.
      The underlying mechanism was not associated with changes in readily releasable
      pool size or Ca2+ dynamics, but rather resulted from superpriming a subset of
      synaptic vesicles. Hence, Doc2 forms part of the Ca2+-sensing apparatus for
      synaptic augmentation via a mechanism that is molecularly distinct from other
      forms of short-term plasticity.

PMID- 29844165
TI  - The glycerol backbone of phospholipids derives from noncarbohydrate precursors in
      starved lung cancer cells.
AB  - Cancer cells are reprogrammed to consume large amounts of glucose to support
      anabolic biosynthetic pathways. However, blood perfusion and consequently the
      supply with glucose are frequently inadequate in solid cancers. PEPCK-M (PCK2),
      the mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK), has been
      shown by us and others to be functionally expressed and to mediate
      gluconeogenesis, the reverse pathway of glycolysis, in different cancer cells.
      Serine and ribose synthesis have been identified as downstream pathways fed by
      PEPCK in cancer cells. Here, we report that PEPCK-M-dependent glycerol phosphate
      formation from noncarbohydrate precursors (glyceroneogenesis) occurs in starved
      lung cancer cells and supports de novo glycerophospholipid synthesis. Using
      stable isotope-labeled glutamine and lactate, we show that PEPCK-M generates
      phosphoenolpyruvate and 3-phosphoglycerate, which are at least partially
      converted to glycerol phosphate and incorporated into glycerophospholipids (GPL)
      under glucose and serum starvation. This pathway is required to maintain levels
      of GPL, especially phosphatidylethanolamine (PE), as shown by stable shRNA
      mediated silencing of PEPCK-M in H23 lung cancer cells. PEPCK-M shRNA led to
      reduced colony formation after starvation, and the effect was partially reversed
      by the addition of dioleyl-PE. Furthermore, PEPCK-M silencing abrogated cancer
      growth in a lung cancer cell xenograft model. In conclusion, glycerol phosphate
      formation for de novo GPL synthesis via glyceroneogenesis is a newly
      characterized anabolic pathway in cancer cells mediated by PEPCK-M under
      conditions of severe nutrient deprivation.

PMID- 29844166
TI  - Limiting global-mean temperature increase to 1.5-2  degrees C could reduce the
      incidence and spatial spread of dengue fever in Latin America.
AB  - The Paris Climate Agreement aims to hold global-mean temperature well below 2 
      degrees C and to pursue efforts to limit it to 1.5  degrees C above preindustrial
      levels. While it is recognized that there are benefits for human health in
      limiting global warming to 1.5  degrees C, the magnitude with which those
      societal benefits will be accrued remains unquantified. Crucial to public health
      preparedness and response is the understanding and quantification of such impacts
      at different levels of warming. Using dengue in Latin America as a study case, a
      climate-driven dengue generalized additive mixed model was developed to predict
      global warming impacts using five different global circulation models, all scaled
      to represent multiple global-mean temperature assumptions. We show that policies
      to limit global warming to 2  degrees C could reduce dengue cases by about 2.8
      (0.8-7.4) million cases per year by the end of the century compared with a no
      policy scenario that warms by 3.7  degrees C. Limiting warming further to 1.5 
      degrees C produces an additional drop in cases of about 0.5 (0.2-1.1) million per
      year. Furthermore, we found that by limiting global warming we can limit the
      expansion of the disease toward areas where incidence is currently low. We
      anticipate our study to be a starting point for more comprehensive studies
      incorporating socioeconomic scenarios and how they may further impact dengue
      incidence. Our results demonstrate that although future climate change may
      amplify dengue transmission in the region, impacts may be avoided by constraining
      the level of warming.

PMID- 29844167
TI  - Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by
      HoxB13.
AB  - The constitutively active androgen receptor (AR) splice variant 7 (AR-V7) plays
      an important role in the progression of castration-resistant prostate cancer
      (CRPC). Although biomarker studies established the role of AR-V7 in resistance to
      AR-targeting therapies, how AR-V7 mediates genomic functions in CRPC remains
      largely unknown. Using a ChIP-exo approach, we show AR-V7 binds to distinct
      genomic regions and recognizes a full-length androgen-responsive element in CRPC
      cells and patient tissues. Remarkably, we find dramatic differences in AR-V7
      cistromes across diverse CRPC cells and patient tissues, regulating different
      target gene sets involved in CRPC progression. Surprisingly, we discover that
      HoxB13 is universally required for and colocalizes with AR-V7 binding to open
      chromatin across CRPC genomes. HoxB13 pioneers AR-V7 binding through direct
      physical interaction, and collaborates with AR-V7 to up-regulate target
      oncogenes. Transcriptional coregulation by HoxB13 and AR-V7 was further supported
      by their coexpression in tumors and circulating tumor cells from CRPC patients.
      Importantly, HoxB13 silencing significantly decreases CRPC growth through
      inhibition of AR-V7 oncogenic function. These results identify HoxB13 as a
      pivotal upstream regulator of AR-V7-driven transcriptomes that are often cell
      context-dependent in CRPC, suggesting that HoxB13 may serve as a therapeutic
      target for AR-V7-driven prostate tumors.

PMID- 29844169
TI  - How electrostatic networks modulate specificity and stability of collagen.
AB  - One-quarter of the 28 types of natural collagen exist as heterotrimers. The
      oligomerization state of collagen affects the structure and mechanics of the
      extracellular matrix, providing essential cues to modulate biological and
      pathological processes. A lack of high-resolution structural information limits
      our mechanistic understanding of collagen heterospecific self-assembly. Here, the
      1.77-A resolution structure of a synthetic heterotrimer demonstrates the balance
      of intermolecular electrostatics and hydrogen bonding that affects collagen
      stability and heterospecificity of assembly. Atomistic simulations and
      mutagenesis based on the solved structure are used to explore the contributions
      of specific interactions to energetics. A predictive model of collagen stability
      and specificity is developed for engineering novel collagen structures.

PMID- 29844168
TI  - Activated integrins identify functional antigen-specific CD8+ T cells within
      minutes after antigen stimulation.
AB  - Immediate beta2-integrin activation upon T cell receptor stimulation is critical
      for effective interaction between T cells and their targets and may therefore be
      used for the rapid identification and isolation of functional T cells. We present
      a simple and sensitive flow cytometry-based assay to assess antigen-specific T
      cells using fluorescent intercellular adhesion molecule (ICAM)-1 multimers that
      specifically bind to activated beta2-integrins. The method is compatible with
      surface and intracellular staining; it is applicable for monitoring of a broad
      range of virus-, tumor-, and vaccine-specific CD8+ T cells, and for isolating
      viable antigen-reacting cells. ICAM-1 binding correlates with peptide-MHC
      multimer binding but, notably, it identifies the fraction of antigen-specific
      CD8+ T cells with immediate and high functional capability (i.e., expressing high
      levels of cytotoxic markers and cytokines). Compared with the currently available
      methods, staining of activated beta2-integrins presents the unique advantage of
      requiring activation times of only several minutes, therefore delivering
      functional information nearly reflecting the in vivo situation. Hence, the ICAM-1
      assay is most suitable for rapid and precise monitoring of functional antigen
      specific T cell responses, including for patient samples in a variety of clinical
      settings, as well as for the isolation of functional T cells for adoptive cell
      transfer immunotherapies.

PMID- 29844170
TI  - Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in
      the nuclear exosome-targeting complex.
AB  - The nuclear exosome-targeting (NEXT) complex functions as an RNA exosome cofactor
      and is involved in surveillance and turnover of aberrant transcripts and
      noncoding RNAs. NEXT is a ternary complex composed of the RNA-binding protein
      RBM7, the scaffold zinc-knuckle protein ZCCHC8, and the helicase MTR4. While RNA
      interactions with RBM7 are known, it remains unclear how NEXT subunits
      collaborate to recognize and prepare substrates for degradation. Here, we show
      that MTR4 helicase activity is enhanced when associated with RBM7 and ZCCHC8.
      While uridine-rich substrates interact with RBM7 and are preferred, optimal
      activity is observed when substrates include a polyadenylated 3' end. We identify
      a bipartite interaction of ZCCHC8 with MTR4 and uncover a role for the conserved
      C-terminal domain of ZCCHC8 in stimulating MTR4 helicase and ATPase activities. A
      crystal structure reveals that the ZCCHC8 C-terminal domain binds the helicase
      core in a manner that is distinct from that observed for Saccharomyces cerevisiae
      exosome cofactors Trf4p and Air2p. Our results are consistent with a model
      whereby effective targeting of substrates by NEXT entails recognition of elements
      within the substrate and activation of MTR4 helicase activity.

PMID- 29844171
TI  - Dynamic action potential clamp predicts functional separation in mild familial
      and severe de novo forms of SCN2A epilepsy.
AB  - De novo variants in SCN2A developmental and epileptic encephalopathy (DEE) show
      distinctive genotype-phenotype correlations. The two most recurrent SCN2A
      variants in DEE, R1882Q and R853Q, are associated with different ages and seizure
      types at onset. R1882Q presents on day 1 of life with focal seizures, while
      infantile spasms is the dominant seizure type seen in R853Q cases, presenting at
      a median age of 8 months. Voltage clamp, which characterizes the functional
      properties of ion channels, predicted gain-of-function for R1882Q and loss-of
      function for R853Q. Dynamic action potential clamp, that we implement here as a
      method for modeling neurophysiological consequences of a given epilepsy variant,
      predicted that the R1882Q variant would cause a dramatic increase in firing,
      whereas the R853Q variant would cause a marked reduction in action potential
      firing. Dynamic clamp was also able to functionally separate the L1563V variant,
      seen in benign familial neonatal-infantile seizures from R1882Q, seen in DEE,
      suggesting a diagnostic potential for this type of analysis. Overall, the study
      shows a strong correlation between clinical phenotype, SCN2A genotype, and
      functional modeling. Dynamic clamp is well positioned to impact our understanding
      of pathomechanisms and for development of disease mechanism-targeted therapies in
      genetic epilepsy.

PMID- 29844173
TI  - Correction for Nepomnyachiy et al., Complex evolutionary footprints revealed in
      an analysis of reused protein segments of diverse lengths.

PMID- 29844172
TI  - Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis.
AB  - Mesenchymal cells in the microenvironment of cancer exert important functions in
      tumorigenesis; however, little is known of intrinsic pathways that mediate these
      effects. MAPK signals, such as from MAPKAPK2 (MK2) are known to modulate
      tumorigenesis, yet their cell-specific role has not been determined. Here, we
      studied the cell-specific role of MK2 in intestinal carcinogenesis using complete
      and conditional ablation of MK2. We show that both genetic and chemical
      inhibition of MK2 led to decreased epithelial cell proliferation, associated with
      reduced tumor growth and invasive potential in the Apcmin/+ mouse model. Notably,
      this function of MK2 was not mediated by its well-described immunomodulatory role
      in immune cells. Deletion of MK2 in intestinal mesenchymal cells (IMCs) led to
      both reduced tumor multiplicity and growth. Mechanistically, MK2 in IMCs was
      required for Hsp27 phosphorylation and the production of downstream tumorigenic
      effector molecules, dominantly affecting epithelial proliferation, apoptosis, and
      angiogenesis. Genetic ablation of MK2 in intestinal epithelial or endothelial
      cells was less effective in comparison with its complete deletion, leading to
      reduction of tumor size via modulation of epithelial apoptosis and angiogenesis
      associated proliferation, respectively. Similar results were obtained in a model
      of colitis-associated carcinogenesis, indicating a mesenchymal-specific role for
      MK2 also in this model. Our findings demonstrate the central pathogenic role of
      mesenchymal-specific MK2/Hsp27 axis in tumorigenesis and highlight the value of
      mesenchymal MK2 inhibition in the treatment of cancer.

PMID- 29844174
TI  - Face recognition accuracy of forensic examiners, superrecognizers, and face
      recognition algorithms.
AB  - Achieving the upper limits of face identification accuracy in forensic
      applications can minimize errors that have profound social and personal
      consequences. Although forensic examiners identify faces in these applications,
      systematic tests of their accuracy are rare. How can we achieve the most accurate
      face identification: using people and/or machines working alone or in
      collaboration? In a comprehensive comparison of face identification by humans and
      computers, we found that forensic facial examiners, facial reviewers, and
      superrecognizers were more accurate than fingerprint examiners and students on a
      challenging face identification test. Individual performance on the test varied
      widely. On the same test, four deep convolutional neural networks (DCNNs),
      developed between 2015 and 2017, identified faces within the range of human
      accuracy. Accuracy of the algorithms increased steadily over time, with the most
      recent DCNN scoring above the median of the forensic facial examiners. Using
      crowd-sourcing methods, we fused the judgments of multiple forensic facial
      examiners by averaging their rating-based identity judgments. Accuracy was
      substantially better for fused judgments than for individuals working alone.
      Fusion also served to stabilize performance, boosting the scores of lower
      performing individuals and decreasing variability. Single forensic facial
      examiners fused with the best algorithm were more accurate than the combination
      of two examiners. Therefore, collaboration among humans and between humans and
      machines offers tangible benefits to face identification accuracy in important
      applications. These results offer an evidence-based roadmap for achieving the
      most accurate face identification possible.

PMID- 29844176
TI  - Correction for Spence et al., Revealing the specificity of regulatory T cells in
      murine autoimmune diabetes.

PMID- 29844175
TI  - Increase in chemokine CXCL1 by ERbeta ligand treatment is a key mediator in
      promoting axon myelination.
AB  - Estrogen receptor beta (ERbeta) ligands promote remyelination in mouse models of
      multiple sclerosis. Recent work using experimental autoimmune encephalomyelitis
      (EAE) has shown that ERbeta ligands induce axon remyelination, but impact
      peripheral inflammation to varying degrees. To identify if ERbeta ligands
      initiate a common immune mechanism in remyelination, central and peripheral
      immunity and pathology in mice given ERbeta ligands at peak EAE were assessed.
      All ERbeta ligands induced differential expression of cytokines and chemokines,
      but increased levels of CXCL1 in the periphery and in astrocytes. Oligodendrocyte
      CXCR2 binds CXCL1 and has been implicated in normal myelination. In addition,
      despite extensive immune cell accumulation in the CNS, all ERbeta ligands
      promoted extensive remyelination in mice at peak EAE. This finding highlights a
      component of the mechanism by which ERbeta ligands mediate remyelination. Hence,
      interplay between the immune system and central nervous system may be responsible
      for the remyelinating effects of ERbeta ligands. Our findings of potential
      neuroprotective benefits arising from the presence of CXCL1 could have
      implications for improved therapies for multiple sclerosis.

PMID- 29844177
TI  - Functional diversification of Arabidopsis SEC1-related SM proteins in cytokinetic
      and secretory membrane fusion.
AB  - Sec1/Munc18 (SM) proteins contribute to membrane fusion by interacting with Qa
      SNAREs or nascent trans-SNARE complexes. Gymnosperms and the basal angiosperm
      Amborella have only a single SEC1 gene related to the KEULE gene in Arabidopsis
      However, the genomes of most angiosperms including Arabidopsis encode three SEC1
      related SM proteins of which only KEULE has been functionally characterized as
      interacting with the cytokinesis-specific Qa-SNARE KNOLLE during cell-plate
      formation. Here we analyze the closest paralog of KEULE named SEC1B. In contrast
      to the cytokinesis defects of keule mutants, sec1b mutants are homozygous viable.
      However, the keule sec1b double mutant was nearly gametophytically lethal,
      displaying collapsed pollen grains, which suggests substantial overlap between
      SEC1B and KEULE functions in secretion-dependent growth. SEC1B had a strong
      preference for interaction with the evolutionarily ancient Qa-SNARE SYP132
      involved in secretion and cytokinesis, whereas KEULE interacted with both KNOLLE
      and SYP132. This differential interaction with Qa-SNAREs is likely conferred by
      domains 1 and 2a of the two SM proteins. Comparative analysis of all four
      possible combinations of the relevant SEC1 Qa-SNARE double mutants revealed that
      in cytokinesis, the interaction of SEC1B with KNOLLE plays no role, whereas the
      interaction of KEULE with KNOLLE is prevalent and functionally as important as
      the interactions of both SEC1B and KEU with SYP132 together. Our results suggest
      that functional diversification of the two SEC1-related SM proteins during
      angiosperm evolution resulted in enhanced interaction of SEC1B with Qa-SNARE
      SYP132, and thus a predominant role of SEC1B in secretion.

PMID- 29844179
TI  - Experimental evidence for delayed contingent cooperation among wild dwarf
      mongooses.
AB  - Many animals participate in biological markets, with strong evidence existing for
      immediate cooperative trades. In particular, grooming is often exchanged for
      itself or other commodities, such as coalitionary support or access to food and
      mates. More contentious is the possibility that nonhuman animals can rely on
      memories of recent events, providing contingent cooperation even when there is a
      temporal delay between two cooperative acts. Here we provide experimental
      evidence of delayed cross-commodity grooming exchange in wild dwarf mongooses
      (Helogale parvula). First, we use natural observations and social-network
      analyses to demonstrate a positive link between grooming and sentinel behavior
      (acting as a raised guard). Group members who contributed more to sentinel
      behavior received more grooming and had a better social-network position. We then
      used a field-based playback experiment to test a causal link between
      contributions to sentinel behavior and grooming received later in the day. During
      3-h trial sessions, the perceived sentinel contributions of a focal individual
      were either up-regulated (playback of its surveillance calls, which are given
      naturally during sentinel bouts) or unmanipulated (playback of its foraging close
      calls as a control). On returning to the sleeping refuge at the end of the day,
      focal individuals received more grooming following surveillance-call playback
      than control-call playback and more grooming than a matched individual whose
      sentinel contributions were not up-regulated. We believe our study therefore
      provides experimental evidence of delayed contingent cooperation in a wild
      nonprimate species.

PMID- 29844178
TI  - Fluctuating hydrogen-bond networks govern anomalous electron transfer kinetics in
      a blue copper protein.
AB  - We combine experimental and computational methods to address the anomalous
      kinetics of long-range electron transfer (ET) in mutants of Pseudomonas
      aeruginosa azurin. ET rates and driving forces for wild type (WT) and three N47X
      mutants (X = L, S, and D) of Ru(2,2'-bipyridine)2 (imidazole)(His83) azurin are
      reported. An enhanced ET rate for the N47L mutant suggests either an increase of
      the donor-acceptor (DA) electronic coupling or a decrease in the reorganization
      energy for the reaction. The underlying atomistic features are investigated using
      a recently developed nonadiabatic molecular dynamics method to simulate ET in
      each of the azurin mutants, revealing unexpected aspects of DA electronic
      coupling. In particular, WT azurin and all studied mutants exhibit more DA
      compression during ET (>2 A) than previously recognized. Moreover, it is found
      that DA compression involves an extended network of hydrogen bonds, the
      fluctuations of which gate the ET reaction, such that DA compression is
      facilitated by transiently rupturing hydrogen bonds. It is found that the N47L
      mutant intrinsically disrupts this hydrogen-bond network, enabling particularly
      facile DA compression. This work, which reveals the surprisingly fluctional
      nature of ET in azurin, suggests that hydrogen-bond networks can modulate the
      efficiency of long-range biological ET.

PMID- 29844181
TI  - Mapping an ancient city with a century of remotely sensed data.
AB  - The rapidly growing global population places cultural heritage at great risk, and
      the encroachment of modern settlement on archaeological sites means that valuable
      information about how past societies worked and interacted with the environment
      is lost. To manage and mitigate these risks, we require knowledge about what has
      been lost and what remains, so we can actively decide what should be investigated
      and what should be preserved for the future. Remote sensing provides
      archaeologists with some of the tools we need to do this. In this paper we
      explore the application of multitemporal, multisensor data to map features and
      chart the impacts of urban encroachment on the ancient city of Jerash (in modern
      Jordan) by combining archives of aerial photography dating back to 1917 with
      state-of-the-art airborne laser scanning. The combined results revealed details
      of the water distribution system and the ancient city plan. This demonstrates
      that by combining historical images with modern aerial and ground-based data we
      can successfully detect and contextualize these features and thus achieve a
      better understanding of life in a city in the past. These methods are essential,
      given that much of the ancient city has been lost to modern development and the
      historical imagery is often our only source of information.

PMID- 29844182
TI  - MINFLUX monitors rapid molecular jumps with superior spatiotemporal resolution.
AB  - Compared with localization schemes solely based on evaluating patterns of
      molecular emission, the recently introduced single-molecule localization concept
      called MINFLUX and the fluorescence nanoscopies derived from it require up to
      orders of magnitude fewer emissions to attain single-digit nanometer resolution.
      Here, we demonstrate that the lower number of required fluorescence photons
      enables MINFLUX to detect molecular movements of a few nanometers at a temporal
      sampling of well below 1 millisecond. Using fluorophores attached to thermally
      fluctuating DNA strands as model systems, we demonstrate that measurement times
      as short as 400 microseconds suffice to localize fluorescent molecules with ~2-nm
      precision. Such performance is out of reach for popular camera-based localization
      by centroid calculation of emission diffraction patterns. Since theoretical
      limits have not been reached, our results show that emerging MINFLUX nanoscopy
      bears great potential for dissecting the motions of individual (macro)molecules
      at hitherto-unattained combinations of spatial and temporal resolution.

PMID- 29844180
TI  - In vitro reconstitution of sortase-catalyzed pilus polymerization reveals
      structural elements involved in pilin cross-linking.
AB  - Covalently cross-linked pilus polymers displayed on the cell surface of Gram
      positive bacteria are assembled by class C sortase enzymes. These pilus-specific
      transpeptidases located on the bacterial membrane catalyze a two-step protein
      ligation reaction, first cleaving the LPXTG motif of one pilin protomer to form
      an acyl-enzyme intermediate and then joining the terminal Thr to the nucleophilic
      Lys residue residing within the pilin motif of another pilin protomer. To date,
      the determinants of class C enzymes that uniquely enable them to construct pili
      remain unknown. Here, informed by high-resolution crystal structures of
      corynebacterial pilus-specific sortase (SrtA) and utilizing a structural variant
      of the enzyme (SrtA2M), whose catalytic pocket has been unmasked by activating
      mutations, we successfully reconstituted in vitro polymerization of the cognate
      major pilin (SpaA). Mass spectrometry, electron microscopy, and biochemical
      experiments authenticated that SrtA2M synthesizes pilus fibers with correct Lys
      Thr isopeptide bonds linking individual pilins via a thioacyl intermediate.
      Structural modeling of the SpaA-SrtA-SpaA polymerization intermediate depicts
      SrtA2M sandwiched between the N- and C-terminal domains of SpaA harboring the
      reactive pilin and LPXTG motifs, respectively. Remarkably, the model uncovered a
      conserved TP(Y/L)XIN(S/T)H signature sequence following the catalytic Cys, in
      which the alanine substitutions abrogated cross-linking activity but not cleavage
      of LPXTG. These insights and our evidence that SrtA2M can terminate pilus
      polymerization by joining the terminal pilin SpaB to SpaA and catalyze ligation
      of isolated SpaA domains in vitro provide a facile and versatile platform for
      protein engineering and bio-conjugation that has major implications for
      biotechnology.

PMID- 29844183
TI  - Fluctuating radiocarbon offsets observed in the southern Levant and implications
      for archaeological chronology debates.
AB  - Considerable work has gone into developing high-precision radiocarbon (14C)
      chronologies for the southern Levant region during the Late Bronze to Iron
      Age/early Biblical periods (~1200-600 BC), but there has been little
      consideration whether the current standard Northern Hemisphere 14C calibration
      curve (IntCal13) is appropriate for this region. We measured 14C ages of calendar
      dated tree rings from AD 1610 to 1940 from southern Jordan to investigate
      contemporary 14C levels and to compare these with IntCal13. Our data reveal an
      average offset of ~19 14C years, but, more interestingly, this offset seems to
      vary in importance through time. While relatively small, such an offset has
      substantial relevance to high-resolution 14C chronologies for the southern
      Levant, both archaeological and paleoenvironmental. For example, reconsidering
      two published studies, we find differences, on average, of 60% between the 95.4%
      probability ranges determined from IntCal13 versus those approximately allowing
      for the observed offset pattern. Such differences affect, and even potentially
      undermine, several current archaeological and historical positions and
      controversies.

PMID- 29844184
TI  - Consequences of resistance evolution in a Cas9-based sex conversion-suppression
      gene drive for insect pest management.
AB  - The use of a site-specific homing-based gene drive for insect pest control has
      long been discussed, but the easy design of such systems has become possible only
      with the recent establishment of CRISPR/Cas9 technology. In this respect, novel
      targets for insect pest management are provided by new discoveries regarding sex
      determination. Here, we present a model for a suppression gene drive designed to
      cause an all-male population collapse in an agricultural pest insect. To evaluate
      the molecular details of such a sex conversion-based suppression gene drive
      experimentally, we implemented this strategy in Drosophila melanogaster to serve
      as a safe model organism. We generated a Cas9-based homing gene-drive element
      targeting the transformer gene and showed its high efficiency for sex conversion
      from females to males. However, nonhomologous end joining increased the rate of
      mutagenesis at the target site, which resulted in the emergence of drive
      resistant alleles and therefore curbed the gene drive. This confirms previous
      studies that simple homing CRISPR/Cas9 gene-drive designs will be ineffective.
      Nevertheless, by performing population dynamics simulations using the parameters
      we obtained in D. melanogaster and by adjusting the model for the agricultural
      pest Ceratitis capitata, we were able to identify adequate modifications that
      could be successfully applied for the management of wild Mediterranean fruit fly
      populations using our proposed sex conversion-based suppression gene-drive
      strategy.

PMID- 29844185
TI  - Unimolecular reaction of acetone oxide and its reaction with water in the
      atmosphere.
AB  - Criegee intermediates (i.e., carbonyl oxides with two radical sites) are known to
      be important atmospheric reagents; however, our knowledge of their reaction
      kinetics is still limited. Although experimental methods have been developed to
      directly measure the reaction rate constants of stabilized Criegee intermediates,
      the experimental results cover limited temperature ranges and do not completely
      agree well with one another. Here we investigate the unimolecular reaction of
      acetone oxide [(CH3)2COO] and its bimolecular reaction with H2O to obtain rate
      constants with quantitative accuracy comparable to experimental accuracy. We do
      this by using CCSDT(Q)/CBS//CCSD(T)-F12a/DZ-F12 benchmark results to select and
      validate exchange-correlation functionals, which are then used for direct
      dynamics calculations by variational transition state theory with small-curvature
      tunneling and torsional and high-frequency anharmonicity. We find that tunneling
      is very significant in the unimolecular reaction of (CH3)2COO and its bimolecular
      reaction with H2O. We show that the atmospheric lifetimes of (CH3)2COO depend on
      temperature and that the unimolecular reaction of (CH3)2COO is the dominant decay
      mode above 240 K, while the (CH3)2COO + SO2 reaction can compete with the
      corresponding unimolecular reaction below 240 K when the SO2 concentration is 9 *
      1010 molecules per cubic centimeter. We also find that experimental results may
      not be sufficiently accurate for the unimolecular reaction of (CH3)2COO above 310
      K. Not only does the present investigation provide insights into the decay of
      (CH3)2COO in the atmosphere, but it also provides an illustration of how to use
      theoretical methods to predict quantitative rate constants of medium-sized
      Criegee intermediates.

PMID- 29844187
TI  - Correction for Ponce de Leon et al., Human bony labyrinth is an indicator of
      population history and dispersal from Africa.

PMID- 29844186
TI  - Implications of Zika virus and congenital Zika syndrome for the number of live
      births in Brazil.
AB  - An increase in microcephaly, associated with an epidemic of Zika virus (ZIKV) in
      Brazil, prompted the World Health Organization to declare a Public Health
      Emergency of International Concern in February 2016. While knowledge on
      biological and epidemiological aspects of ZIKV has advanced, demographic impacts
      remain poorly understood. This study uses time-series analysis to assess the
      impact of ZIKV on births. Data on births, fetal deaths, and hospitalizations due
      to abortion complications for Brazilian states, from 2010 to 2016, were used.
      Forecasts for September 2015 to December 2016 showed that 119,095 fewer births
      than expected were observed, particularly after April 2016 (a reduction
      significant at 0.05), demonstrating a link between publicity associated with the
      ZIKV epidemic and the decline in births. No significant changes were observed in
      fetal death rates. Although no significant increases in hospitalizations were
      forecasted, after the ZIKV outbreak hospitalizations happened earlier in the
      gestational period in most states. We argue that postponement of pregnancy and an
      increase in abortions may have contributed to the decline in births. Also, it is
      likely that an increase in safe abortions happened, albeit selective by
      socioeconomic status. Thus, the ZIKV epidemic resulted in a generation of
      congenital Zika syndrome (CZS) babies that reflect and exacerbate regional and
      social inequalities. Since ZIKV transmission has declined, it is unlikely that
      reductions in births will continue. However, the possibility of a new epidemic is
      real. There is a need to address gaps in reproductive health and rights, and to
      understand CZS risk to better inform conception decisions.

PMID- 29844188
TI  - KDM4B protects against obesity and metabolic dysfunction.
AB  - Although significant progress has been made in understanding epigenetic
      regulation of in vitro adipogenesis, the physiological functions of epigenetic
      regulators in metabolism and their roles in obesity remain largely elusive. Here,
      we report that KDM4B (lysine demethylase 4B) in adipose tissues plays a critical
      role in energy balance, oxidation, lipolysis, and thermogenesis. Loss of KDM4B in
      mice resulted in obesity associated with reduced energy expenditure and impaired
      adaptive thermogenesis. Obesity in KDM4B-deficient mice was accompanied by
      hyperlipidemia, insulin resistance, and pathological changes in the liver and
      pancreas. Adipocyte-specific deletion of Kdm4b revealed that the adipose tissues
      were the main sites for KDM4B antiobesity effects. KDM4B directly controlled the
      expression of multiple metabolic genes, including Ppargc1a and Ppara
      Collectively, our studies identify KDM4B as an essential epigenetic factor for
      the regulation of metabolic health and maintaining normal body weight in mice.
      KDM4B may provide a therapeutic target for treatment of obesity.

PMID- 29844189
TI  - Potent and selective antitumor activity of a T cell-engaging bispecific antibody
      targeting a membrane-proximal epitope of ROR1.
AB  - T cell-engaging bispecific antibodies (biAbs) present a promising strategy for
      cancer immunotherapy, and numerous bispecific formats have been developed for
      retargeting cytolytic T cells toward tumor cells. To explore the therapeutic
      utility of T cell-engaging biAbs targeting the receptor tyrosine kinase ROR1,
      which is expressed by tumor cells of various hematologic and solid malignancies,
      we used a bispecific ROR1 * CD3 scFv-Fc format based on a heterodimeric and
      aglycosylated Fc domain designed for extended circulatory t1/2 and diminished
      systemic T cell activation. A diverse panel of ROR1-targeting scFv derived from
      immune and naive rabbit antibody repertoires was compared in this bispecific
      format for target-dependent T cell recruitment and activation. An ROR1-targeting
      scFv with a membrane-proximal epitope, R11, revealed potent and selective
      antitumor activity in vitro, in vivo, and ex vivo and emerged as a prime
      candidate for further preclinical and clinical studies. To elucidate the precise
      location and engagement of this membrane-proximal epitope, which is conserved
      between human and mouse ROR1, the 3D structure of scFv R11 in complex with the
      kringle domain of ROR1 was determined by X-ray crystallography at 1.6-A
      resolution.

PMID- 29844191
TI  - Metaproteomics method to determine carbon sources and assimilation pathways of
      species in microbial communities.
AB  - Measurements of stable carbon isotope ratios (delta13C) are widely used in
      biology to address questions regarding food sources and metabolic pathways used
      by organisms. The analysis of these so-called stable isotope fingerprints (SIFs)
      for microbes involved in biogeochemical cycling and microbiota of plants and
      animals has led to major discoveries in environmental microbiology. Currently,
      obtaining SIFs for microbial communities is challenging as the available methods
      either only provide low taxonomic resolution, such as the use of lipid
      biomarkers, or are limited in throughput, such as nanoscale secondary ion MS
      imaging of single cells. Here we present "direct protein-SIF" and the Calis-p
      software package (https://sourceforge.net/projects/calis-p/), which enable high
      throughput measurements of accurate delta13C values for individual species within
      a microbial community. We benchmark the method using 20 pure culture
      microorganisms and show that the method reproducibly provides SIF values
      consistent with gold-standard bulk measurements performed with an isotope ratio
      mass spectrometer. Using mock community samples, we demonstrate that SIF values
      can also be obtained for individual species within a microbial community.
      Finally, a case study of an obligate bacteria-animal symbiosis shows that direct
      protein-SIF confirms previous physiological hypotheses and can provide unexpected
      insights into the symbionts' metabolism. This confirms the usefulness of this
      approach to accurately determine delta13C values for different species in
      microbial community samples.

PMID- 29844192
TI  - QnAs with Rafael Radi.

PMID- 29844190
TI  - Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning.
AB  - C1q, a member of the immune complement cascade, is implicated in the selective
      pruning of synapses by microglial phagocytosis. C1q-mediated synapse elimination
      has been shown to occur during brain development, while increased activation and
      complement-dependent synapse loss is observed in neurodegenerative diseases.
      However, the molecular mechanisms underlying C1q-controlled synaptic pruning are
      mostly unknown. This study addresses distortions in the synaptic proteome leading
      to C1q-tagged synapses. Our data demonstrated the preferential localization of
      C1q to the presynapse. Proteomic investigation and pathway analysis of C1q-tagged
      synaptosomes revealed the presence of apoptotic-like processes in C1q-tagged
      synapses, which was confirmed experimentally with apoptosis markers. Moreover,
      the induction of synaptic apoptotic-like mechanisms in a model of sensory
      deprivation-induced synaptic depression led to elevated C1q levels. Our results
      unveiled that C1q label-based synaptic pruning is triggered by and directly
      linked to apoptotic-like processes in the synaptic compartment.

PMID- 29844194
TI  - Geometric hydrodynamics via Madelung transform.
AB  - We introduce a geometric framework to study Newton's equations on infinite
      dimensional configuration spaces of diffeomorphisms and smooth probability
      densities. It turns out that several important partial differential equations of
      hydrodynamical origin can be described in this framework in a natural way. In
      particular, the Madelung transform between the Schrodinger equation and Newton's
      equations is a symplectomorphism of the corresponding phase spaces. Furthermore,
      the Madelung transform turns out to be a Kahler map when the space of densities
      is equipped with the Fisher-Rao information metric. We describe several dynamical
      applications of these results.

PMID- 29844193
TI  - Gene cluster conservation provides insight into cercosporin biosynthesis and
      extends production to the genus Colletotrichum.
AB  - Species in the genus Cercospora cause economically devastating diseases in sugar
      beet, maize, rice, soy bean, and other major food crops. Here, we sequenced the
      genome of the sugar beet pathogen Cercospora beticola and found it encodes 63
      putative secondary metabolite gene clusters, including the cercosporin toxin
      biosynthesis (CTB) cluster. We show that the CTB gene cluster has experienced
      multiple duplications and horizontal transfers across a spectrum of plant
      pathogenic fungi, including the wide-host range Colletotrichum genus as well as
      the rice pathogen Magnaporthe oryzae Although cercosporin biosynthesis has been
      thought to rely on an eight-gene CTB cluster, our phylogenomic analysis revealed
      gene collinearity adjacent to the established cluster in all CTB cluster
      harboring species. We demonstrate that the CTB cluster is larger than previously
      recognized and includes cercosporin facilitator protein, previously shown to be
      involved with cercosporin autoresistance, and four additional genes required for
      cercosporin biosynthesis, including the final pathway enzymes that install the
      unusual cercosporin methylenedioxy bridge. Lastly, we demonstrate production of
      cercosporin by Colletotrichum fioriniae, the first known cercosporin producer
      within this agriculturally important genus. Thus, our results provide insight
      into the intricate evolution and biology of a toxin critical to agriculture and
      broaden the production of cercosporin to another fungal genus containing many
      plant pathogens of important crops worldwide.

PMID- 29844196
TI  - An intermediate along the recovery stroke of myosin VI revealed by X-ray
      crystallography and molecular dynamics.
AB  - Myosins form a class of actin-based, ATPase motor proteins that mediate important
      cellular functions such as cargo transport and cell motility. Their functional
      cycle involves two large-scale swings of the lever arm: the force-generating
      powerstroke, which takes place on actin, and the recovery stroke during which the
      lever arm is reprimed into an armed configuration. Previous analyses of the
      prerecovery (postrigor) and postrecovery (prepowerstroke) states predicted that
      closure of switch II in the ATP binding site precedes the movement of the
      converter and the lever arm. Here, we report on a crystal structure of myosin VI,
      called pretransition state (PTS), which was solved at 2.2 A resolution.
      Structural analysis and all-atom molecular dynamics simulations are consistent
      with PTS being an intermediate along the recovery stroke, where the Relay/SH1
      elements adopt a postrecovery conformation, and switch II remains open. In this
      state, the converter appears to be largely uncoupled from the motor domain and
      explores an ensemble of partially reprimed configurations through extensive,
      reversible fluctuations. Moreover, we found that the free energy cost of hydrogen
      bonding switch II to ATP is lowered by more than 10 kcal/mol compared with the
      prerecovery state. These results support the conclusion that closing of switch II
      does not initiate the recovery stroke transition in myosin VI. Rather, they
      suggest a mechanism in which lever arm repriming would be mostly driven by
      thermal fluctuations and eventually stabilized by the switch II interaction with
      the nucleotide in a ratchet-like fashion.

PMID- 29844197
TI  - Seminal fluid enhances competitiveness of territorial males' sperm in a fish with
      alternative male reproductive tactics.
AB  - The most common adaptation to sperm competition in males is represented by an
      increase in the sperm number and/or quality released at mating, to raise their
      probability of egg fertilization. However, rapidly mounting evidence highlights
      that seminal fluid may directly influence the competitive fertilization success
      of a male by affecting either own and/or rival sperm performance. In the black
      goby, Gobius niger, an external fertilizer with guard-sneaker mating tactics and
      high sperm competition level, sneaker ejaculates contain less seminal fluid and
      more sperm, that are also of better quality, than those of territorial males.
      However, territorial males gain a higher paternity success inside natural nests.
      Here, we ask whether the seminal fluid can contribute to the reproductive success
      of territorial males by enhancing their sperm performance and/or by decreasing
      that of sneaker males. Using sperm and seminal fluid manipulation and in vitro
      fertilization tests, we found that own seminal fluid influences the velocity and
      fertilization ability of sperm only in territorial males, making them as fast as
      those of sneakers and with a similar fertilization rate. Moreover, both sneaker
      and territorial sperm remain unaffected by the seminal fluid of rival males.
      Thus, black goby males respond to the different level of sperm competition faced
      by differential allocation of sperm and non-sperm components of the ejaculate,
      with sneakers primarily investing in sperm of intrinsic high quality and
      territorial males relying on the effect of seminal fluid to increase the lower
      intrinsic quality of their sperm.

PMID- 29844198
TI  - Can physiological engineering/programming increase multi-generational thermal
      tolerance to extreme temperature events?
AB  - Organisms increasingly encounter higher frequencies of extreme weather events as
      a consequence of global climate change. Currently, few strategies are available
      to mitigate climate change effects on animals arising from acute extreme high
      temperature events. We tested the capacity of physiological engineering to
      influence the intra- and multi-generational upper thermal tolerance capacity of a
      model organism, Artemia, subjected to extreme high temperatures. Enhancement of
      specific physiological regulators during development could affect thermal
      tolerance or life-history attributes affecting subsequent fitness. Using
      experimental Artemia populations, we exposed F0 individuals to one of four
      treatments: heat hardening (28 degrees C to 36 degrees C, 1 degrees C per 10
      min), heat hardening plus serotonin (0.056 MUg ml-1), heat hardening plus
      methionine (0.79 mg ml-1) and a control treatment. Regulator concentrations were
      based on previous literature. Serotonin may promote thermal tolerance, acting
      upon metabolism and life history. Methionine acts as a methylation agent across
      generations. For all groups, measurements were collected for three performance
      traits of individual thermal tolerance (upper sublethal thermal limit, lethal
      limit and dysregulation range) over two generations. The results showed that no
      treatment increased the upper thermal limit during acute thermal stress, although
      serotonin-treated and methionine-treated individuals outperformed controls across
      multiple thermal performance traits. Additionally, some effects were evident
      across generations. Together, these results suggest that phenotypic engineering
      provides complex outcomes, and if implemented with heat hardening can further
      influence performance in multiple thermal tolerance traits, within and across
      generations. Potentially, such techniques could be up-scaled to provide
      resilience and stability in populations susceptible to extreme temperature
      events.

PMID- 29844199
TI  - Almost like a whale - first evidence of suction feeding in a seabird.
AB  - Little auks (Alle alle) are one of the most numerous seabird species in the world
      and feed primarily on copepods in arctic waters. Their high daily energy
      requirements leave them vulnerable to current changes in the arctic plankton
      community, where a smaller, less-profitable copepod species (Calanus
      finmarchicus) becomes increasingly abundant. Little auks have been estimated to
      require ~60,000 copepods per day, necessitating prey capture rates of ~6 copepods
      per second underwater. To achieve such performance, it has been suggested that
      little auks capture their prey by (non-visual) filter feeding. We tested this
      hypothesis by exposing little auks to varying copepod densities within a shallow
      experimental pool and filming their prey capture behaviour. At none of the
      copepod densities tested did birds filter feed. Instead, all birds captured
      copepods by what we identified as visually guided suction feeding, achieved
      through an extension of their sub-lingual pouch. Suction feeding is very common
      in fish and marine mammals, but to the best of our knowledge, this is the first
      time that it has been specifically identified in a seabird species. While
      presumably less efficient than filter feeding, this behaviour may allow little
      auks to foster higher resilience when facing the consequences of arctic climate
      change.

PMID- 29844195
TI  - CFH and VIPR2 as susceptibility loci in choroidal thickness and pachychoroid
      disease central serous chorioretinopathy.
AB  - Central serous chorioretinopathy (CSC) is a common disease affecting younger
      people and may lead to vision loss. CSC shares phenotypic overlap with age
      related macular degeneration (AMD). As recent studies have revealed a
      characteristic increase of choroidal thickness in CSC, we conducted a genome-wide
      association study on choroidal thickness in 3,418 individuals followed by TaqMan
      assays in 2,692 subjects, and we identified two susceptibility loci: CFH
      rs800292, an established AMD susceptibility polymorphism, and VIPR2 rs3793217 (P
      = 2.05 * 10-10 and 6.75 * 10-8, respectively). Case-control studies using
      patients with CSC confirmed associations between both polymorphisms and CSC (P =
      5.27 * 10-5 and 5.14 * 10-5, respectively). The CFH rs800292 G allele is
      reportedly a risk allele for AMD, whereas the A allele conferred risk for thicker
      choroid and CSC development. This study not only shows that susceptibility genes
      for CSC could be discovered using choroidal thickness as a defining variable but
      also, deepens the understanding of differences between CSC and AMD
      pathophysiology.

PMID- 29844200
TI  - Foraging strategy of wasps - optimisation of intake rate or energetic efficiency?
AB  - In endothermic wasps, foraging is an expensive activity. To maximise the benefit
      for the colony, wasps can optimise either the intake rate or energetic efficiency
      of a foraging trip. We investigated the foraging behaviour of vespine wasps under
      variable environmental and reward conditions. We trained them to forage for 0.5
      mol l-1 sucrose solution from an artificial flower in a flow-through respiratory
      measurement chamber, and simultaneously measured their body temperature using
      infrared thermography to investigate interactions between thermoregulation and
      energetics. Measurement of carbon dioxide release (for energetic calculations)
      and load mass enabled the direct determination of foraging efficiency. An
      unlimited reward increased the wasps' energetic effort to increase the suction
      speed through high body temperatures. With reduced reward (limited flow), when an
      increased body temperature could not increase suction speed, the wasps decreased
      their body temperature to reduce the metabolic effort. Solar heat gain was used
      differently, either to increase body temperature without additional metabolic
      effort or to save energy. The foraging efficiency was mainly determined by the
      flow rate, ambient temperature and solar heat gain. In shade, an unlimited
      sucrose flow and a high ambient temperature yielded the highest energetic
      benefit. A limited flow reduced foraging efficiency in the shade, but only partly
      in sunshine. Solar radiation boosted the efficiency at all reward rates. Wasps
      responded flexibly to varying reward conditions by maximising intake rate at
      unlimited flow and switching to the optimisation of foraging efficiency when the
      intake rate could not be enhanced due to a limited flow rate.

PMID- 29844201
TI  - Low thermal dependence of the contractile properties of a wing muscle in the bat
      Carollia perspicillata.
AB  - Temperature affects contractile rate properties in muscle, which may affect
      locomotor performance. Endotherms are known to maintain high core body
      temperatures, but temperatures in the periphery of the body can fluctuate. Such a
      phenomenon occurs in bats, whose wing musculature is relatively poorly insulated,
      resulting in substantially depressed temperatures in the distal wing. We examined
      a wing muscle in the small-bodied tropical bat Carollia perspicillata and a
      hindlimb muscle in the laboratory mouse at 5 degrees C intervals from 22 to 42
      degrees C to determine the thermal dependence of the contractile properties of
      both muscles. We found that the bat extensor carpi radialis longus had low
      thermal dependence from near body temperature to 10 degrees C lower, with Q10
      values of less than 1.5 for relaxation from contraction and shortening velocities
      in that interval, and with no significant difference in some rate properties in
      the interval between 32 and 37 degrees C. In contrast, for all temperature
      intervals below 37 degrees C, Q10 values for the mouse extensor digitorum longus
      were 1.5 or higher, and rate properties differed significantly across successive
      temperature intervals from 37 to 22 degrees C. An ANCOVA analysis found that the
      thermal dependencies of all measured isometric and isotonic rate processes were
      significantly different between the bat and mouse muscles. The relatively low
      thermal dependence of the bat muscle likely represents a downward shift of its
      optimal temperature and may be functionally significant in light of the variable
      operating temperatures of bat wing muscles.

PMID- 29844202
TI  - Transverse anisotropy in the deformation of the muscle during dynamic
      contractions.
AB  - When pennate muscle fibres shorten, the transverse deformation of fibres results
      in an increase in pennation angle of fascicles (bundles of fibres) and transverse
      deformation of muscle belly. Transverse shape changes of a muscle can influence
      force generation. Recent modelling studies predicted asymmetrical transverse
      deformations in the muscle fascicles in the gastrocnemii. However, these
      predictions have not been tested experimentally. As muscle is a 3D entity, it is
      important to explore the structural changes in a 3D perspective to enhance our
      understanding of the underlying structural mechanisms that have functional
      implications. The medial and lateral gastrocnemius muscles from 12 subjects were
      imaged during plantarflexion movements on a dynamometer. The muscle belly was
      simultaneously scanned from two orthogonal directions using two ultrasound
      probes. Fascicle deformations were measured from the two orthogonal ultrasound
      scans to provide 3D information of muscle geometry. Whilst transverse
      deformations in the medial gastrocnemius were similar from the two directions,
      the data for the lateral gastrocnemius confirm that transverse anisotropy can
      occur in the muscle fascicles. As the lateral gastrocnemius fascicle length
      shortened, the pennation angle increased and the fascicles bulged transversally
      in one direction (closest to the typical 2D scanning plane) while thinning in the
      other orthogonal direction. We suggest that the transverse deformation of the
      muscle fascicles depends on the stiffness of the aponeuroses, properties of
      connective tissue structures surrounding muscle, and compressive forces both
      internal and external to the muscle. These results highlight that muscle
      fascicles do not bulge uniformly and the implications for this behaviour on
      muscle function remain largely unexplored.

PMID- 29844203
TI  - Clinical, molecular, and immunological responses to pembrolizumab treatment of
      synchronous melanoma and acute myeloid leukemia.

PMID- 29844204
TI  - Plasma hepcidin is associated with future risk of venous thromboembolism.
AB  - Red cell distribution width (RDW) is associated with venous thromboembolism
      (VTE), but the underlying mechanism(s) is unclear. Iron deficiency is associated
      with high RDW, and studies suggest an association between iron deficiency and
      VTE. To assess whether iron deficiency is a risk factor for VTE that explains the
      association between RDW and VTE, we conducted a nested case-control study of 390
      patients with VTE and 802 age- and sex-matched controls selected from the
      population-based cohort of the Tromso Study. Physical measurements and blood
      samples were collected from 1994 to 1995. Logistic regression models were used to
      calculate odds ratios (ORs) with 95% confidence intervals (CIs) for VTE by RDW,
      hepcidin, and ferritin light chain (FtL). RDW was inversely associated with
      hepcidin, FtL, and hemoglobin. The risk of VTE increased linearly across
      categories of higher plasma hepcidin levels. Participants with hepcidin in the
      highest quartile had an OR for VTE of 1.32 (95% CI, 1.00-2.42), and those in the
      >90% percentile had an OR for VTE of 1.66 (95% CI, 1.14-2.42) compared with the
      reference group (quartiles 2 and 3). The risk estimates remained similar after
      adjustment for C-reactive protein. The risk of VTE increased by categories of
      higher RDW and was strengthened after inclusion of hepcidin and FtL in the
      multivariable model. Our findings reject the hypothesis that iron deficiency
      explains the association between RDW and VTE and suggest, in contrast, that high
      body iron levels might increase the risk of VTE.

PMID- 29844205
TI  - Comparison of pediatric allogeneic transplant outcomes using myeloablative
      busulfan with cyclophosphamide or fludarabine.
AB  - Busulfan combined with cyclophosphamide (BuCy) has long been considered a
      standard myeloablative conditioning regimen for allogeneic hematopoietic cell
      transplantation (HCT), including both nonmalignant conditions and myeloid
      diseases. Substituting fludarabine for cyclophosphamide (BuFlu) to reduce
      toxicity without an increase in relapse has been increasingly performed in
      children, but without comparison with BuCy. We retrospectively analyzed 1781
      children transplanted from 2008 to 2014 to compare the effectiveness of BuCy with
      BuFlu. Nonmalignant and malignant disease populations were analyzed separately.
      Overall mortality was comparable for children with nonmalignant conditions who
      received BuFlu or BuCy (relative risk [RR], 1.14, P = .52). Lower incidences of
      sinusoidal obstruction syndrome (P = .04), hemorrhagic cystitis (P = .04), and
      chronic graft-versus-host disease (P = .02) were observed after BuFlu, but the
      influence of the conditioning regimen could not be assessed by multivariate
      analysis because of the low frequency of these complications. Children
      transplanted for malignancies were more likely to receive BuFlu if they had
      higher hematopoietic cell transplantation-comorbidity index scores (P < .001) or
      their donor was unrelated and HLA-mismatched (P = .004). Nevertheless, there were
      no differences in transplant toxicities and comparable transplant-related
      mortality (RR, 1.2; P = .46), relapse (RR, 1.2; P = .15), and treatment failure
      (RR, 1.2; P = .12). BuFlu was associated with higher overall mortality (RR, 1.4;
      P = .008) related to inferior postrelapse survival (P = .001). Our findings
      demonstrated that outcomes after BuFlu are similar to those for BuCy for
      children, but for unclear reasons, those receiving BuFlu for malignancy may be at
      risk for shorter postrelapse survival.

PMID- 29844206
TI  - Activation of the vitamin D receptor transcription factor stimulates the growth
      of definitive erythroid progenitors.
AB  - The pathways that regulate the growth of erythroid progenitors are incompletely
      understood. In a computational analysis of gene expression changes during
      erythroid ontogeny, the vitamin D receptor (Vdr) nuclear hormone receptor
      transcription factor gene was identified in fetal and adult stages, but not at
      the embryonic stage of development. Vdr was expressed in definitive erythroid
      (EryD) progenitors and was downregulated during their maturation. Activation of
      Vdr signaling by the vitamin D3 agonist calcitriol increased the outgrowth of
      EryD colonies from fetal liver and adult bone marrow, maintained progenitor
      potential, and delayed erythroid maturation, as revealed by clonogenic assays,
      suspension culture, cell surface phenotype, and gene expression analyses. The
      early (cKit+CD71lo/neg), but not the late (cKit+CD71hi), EryD progenitor subset
      of LinnegcKit+ cells was responsive to calcitriol. Culture of cKit+CD71lo/neg
      progenitors in the presence of both vitamin D3 and glucocorticoid receptor
      ligands resulted in an increase in proliferation that was at least additive
      compared with either ligand alone. Lentivirus shRNA-mediated knockdown of Vdr
      expression abrogated the stimulation of early erythroid progenitor growth by
      calcitriol. These findings suggest that Vdr has a cell-intrinsic function in
      early erythroid progenitors. Targeting of downstream components of the Vdr
      signaling pathway may lead to new approaches for the expansion of erythroid
      progenitors ex vivo.

PMID- 29844209
TI  - Incorporating a Nebulizer System Into High-Flow Nasal Cannula Improves Comfort in
      Infants With Bronchiolitis.
AB  - BACKGROUND: High-flow nasal cannula (HFNC) is increasingly used to provide
      respiratory support in infants with bronchiolitis. The delivery of aerosol
      therapy through a jet nebulizer is widely indicated despite its controversial
      efficacy and poor tolerability. METHODS: This randomized cross-over study aimed
      to evaluate the comfort and satisfaction of the delivery of aerosol therapy using
      a nebulization system integrated into HFNC compared with the standard practice of
      using a jet nebulizer with a face mask. The COMFORT-Behavior (COMFORT-B) scale, a
      visual analog scale, and a numeric rating scale were used by health professionals
      and caregivers to assess subjects' levels of comfort and satisfaction. RESULTS: A
      total of 113 nebulizations (64 via nebulizer with HFNC; 49 via jet nebulizer)
      were delivered to the 6 subjects included in the study. Use of the nebulizer with
      HFNC showed increased comfort and satisfaction during nebulization compared to
      use of the jet nebulizer, as measured by the COMFORT-B scale, the visual analog
      scale, and the numeric rating scale, with the following median (interquartile
      range) scores: 10.7 (7-16) versus 14.5 (10-20) (P = .006), 8.5 (6-10) versus 7 (4
      9) (P = .02), and 3.84 (3.61-4.07) versus 1.83 (1.58-2.08) (P < .001),
      respectively. Correlation between the COMFORT-B scale and the visual analog scale
      using Spearman's rho was -0.757 (P < .001). The intraclass correlation
      coefficient for the COMFORT-B scale, visual analog scale, and numeric rating
      scale, as measured by 2 different nurses, was between 0.75 and 0.87. CONCLUSIONS:
      The use of a nebulizer incorporated into HFNC therapy results in an increased
      level of comfort and satisfaction compared to the use of a conventional jet
      nebulizer in subjects with bronchiolitis who required HFNC therapy. Further
      studies are needed to determine whether aerosol therapy delivered through HFNC
      improves the clinical course of this pathology.

PMID- 29844207
TI  - Cardiometabolic risk in polycystic ovary syndrome.
AB  - Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive
      age. Besides hyperandrogenism, oligomenorrhea and fertility issues, it is
      associated with a high prevalence of metabolic disorders and cardiovascular risk
      factors. Several genetic polymorphisms have been identified for possible
      associations with cardiometabolic derangements in PCOS. Different PCOS phenotypes
      differ significantly in their cardiometabolic risk, which worsens with severity
      of androgen excess. Due to methodological difficulties, longer time-scale data
      about cardiovascular morbidity and mortality in PCOS and about possible
      beneficial effects of different treatment interventions is missing leaving many
      issues regarding cardiovascular risk unresolved.

PMID- 29844208
TI  - Mechanisms of Crystalloid versus Colloid Osmosis across the Peritoneal Membrane.
AB  - Background Osmosis drives transcapillary ultrafiltration and water removal in
      patients treated with peritoneal dialysis. Crystalloid osmosis, typically induced
      by glucose, relies on dialysate tonicity and occurs through endothelial aquaporin
      1 water channels and interendothelial clefts. In contrast, the mechanisms
      mediating water flow driven by colloidal agents, such as icodextrin, and
      combinations of osmotic agents have not been evaluated.Methods We used
      experimental models of peritoneal dialysis in mouse and biophysical studies
      combined with mathematical modeling to evaluate the mechanisms of colloid versus
      crystalloid osmosis across the peritoneal membrane and to investigate the
      pathways mediating water flow generated by the glucose polymer
      icodextrin.ResultsIn silico modeling and in vivo studies showed that deletion of
      aquaporin-1 did not influence osmotic water transport induced by icodextrin but
      did affect that induced by crystalloid agents. Water flow induced by icodextrin
      was dependent upon the presence of large, colloidal fractions, with a reflection
      coefficient close to unity, a low diffusion capacity, and a minimal effect on
      dialysate osmolality. Combining crystalloid and colloid osmotic agents in the
      same dialysis solution strikingly enhanced water and sodium transport across the
      peritoneal membrane, improving ultrafiltration efficiency over that obtained with
      either type of agent alone.Conclusions These data cast light on the molecular
      mechanisms involved in colloid versus crystalloid osmosis and characterize novel
      osmotic agents. Dialysis solutions combining crystalloid and colloid particles
      may help restore fluid balance in patients treated with peritoneal dialysis.

PMID- 29844210
TI  - Efficacy of Interventions to Improve Respiratory Function After Stroke.
AB  - BACKGROUND: The aim of this study was to systematically review all current
      interventions that have been utilized to improve respiratory function and
      activity after stroke. METHODS: Specific searches were conducted. The
      experimental intervention had to be planned, structured, repetitive, purposive,
      and delivered with the aim of improving respiratory function. Outcomes included
      respiratory strength (maximum inspiratory pressure [PImax], maximum expiratory
      pressure [PEmax]) and endurance, lung function (FVC, FEV1, and peak expiratory
      flow [PEF]), dyspnea, and activity. The quality of the randomized trials was
      assessed by the PEDro scale using scores from the Physiotherapy Evidence Database
      (www.pedro.org.au), and risk of bias was assessed in accordance with the Cochrane
      Handbook for Systematic Reviews of Interventions. RESULTS: The 17 included trials
      had a mean PEDro score of 5.7 (range 4-8) and involved 616 participants. Meta
      analyses showed that respiratory muscle training significantly improved all
      outcomes of interest: PImax (weighted mean difference 11 cm H2O, 95% CI 7-15, I2
      = 0%), PEmax (8 cm H2O, 95% CI 2-15, I2 = 65%), FVC (0.25 L, 95% CI 0.12-0.37, I2
      = 29%), FEV1 (0.24 L, 95% CI 0.17-0.30, I2 = 0%), PEF (0.51 L/s, 95% CI 0.10
      0.92, I2 = 0%), dyspnea (standardized mean difference -1.6 points, 95% CI -2.2 to
      -0.9; I2 = 0%), and activity (standardized mean difference 0.78, 95% CI 0.22
      1.35, I2 = 0%). Meta-analyses found no significant results for the effects of
      breathing exercises on lung function. For the remaining interventions (ie,
      aerobic and postural exercises) and the addition of electrical stimulation, meta
      analyses could not be performed. CONCLUSIONS: This systematic review reports 5
      possible interventions used to improve respiratory function after stroke.
      Respiratory muscle training proved to be effective for improving inspiratory and
      expiratory strength, lung function, and dyspnea, and benefits were carried over
      to activity. However, there is still no evidence to accept or refute the efficacy
      of aerobic, breathing, and postural exercises, or the addition of electrical
      stimulation in respiratory function.

PMID- 29844211
TI  - Performances of CPAP Devices With an Oronasal Mask.
AB  - BACKGROUND: The aim of this bench study was to investigate the performances of 8
      devices for noninvasive CPAP. METHODS: Eight devices for noninvasive CPAP with an
      orofacial mask were studied: Ventumask, Ventumask 30, EasyVent, EasyVent
      Emergency, Compact Model II, Flowone, Superflow, Boussignac CPAP valve. Each
      device was tested at oxygen input flows from 5 to 20 L/min, and the output gas
      flow was measured in static conditions. Each device was evaluated during a
      eupneic and a tachypneic simulated breathing test. RESULTS: The gas output flow
      generated by each device increased with higher oxygen input flow; EasyVent and
      Flowone produced the highest output flow (P < .001). At the simulated eupneic
      breathing test, Superflow and EasyVent showed a more stable pressure swing at
      different PEEP levels, whereas the other masks had a greater swing, between 10
      and 15 cm H2O PEEP (P = .002 for all pairwise comparisons). During the tachypneic
      breathing test, the pressure swing was stable with Flowone and EasyVent (P =
      .055), whereas it had increased with other masks (P = .002 for all pairwise
      comparisons). CONCLUSIONS: We found a significant variation in the performances
      of the 8 CPAP devices examined in this study. The technical characteristics and
      limitations of different CPAP devices should be considered when using in patients
      with hypoxemic acute respiratory failure.

PMID- 29844212
TI  - Mechanical Ventilation-Related Safety Incidents in General Care Wards and ICU
      Settings.
AB  - BACKGROUND: Although the ICU is the most appropriate place to care for
      mechanically ventilated patients, a considerable number are ventilated in general
      medical care wards all over the world. However, adverse events focusing on
      mechanically ventilated patients in general care have not been explored. METHODS:
      Data from the Japan Council for Quality Health Care database were analyzed.
      Patient safety incidents from January 2010 to November 2017 regarding mechanical
      ventilation were collected, and comparisons of patient safety incidents between
      ICUs/high care units (HCUs) and general care wards were made. RESULTS: We
      identified 261 adverse events (with at least 20 adverse events resulting in
      death) and 702 near-miss events related to mechanical ventilation in Japan
      between 2010 and 2017. Furthermore, among all adverse events, 19% (49 of 261
      events) caused serious harm (residual disability or death). Human-factor issues
      were most frequent in both ICU/HCU and general care settings (55% and 53%,
      respectively), while knowledge-based errors were higher in the general care
      setting. CONCLUSIONS: Human-factor issues were the most frequent reasons in both
      settings, while knowledge-based error rates were higher in general care. Our
      results suggest that proper education and training is needed to minimize patient
      safety incidents in facilities without respiratory therapists.

PMID- 29844213
TI  - Positive Correlation Between Regional Cerebral Oxygen Saturation and Mixed Venous
      Oxygen Saturation During Off-Pump Coronary Artery Bypass Surgery.
AB  - BACKGROUND: The balance of oxygen delivery and consumption is essential in
      patients who are critically ill. Mixed venous oxygen saturation (SvO2 ) is a
      standard method to evaluate oxygen delivery and consumption during anesthesia.
      However, SvO2 is monitored through a pulmonary artery catheter, which is
      invasive. Regional cerebral oxygenation (rScO2) reflects oxygen saturation in a
      small region of the frontal lobes and is monitored noninvasively through near
      infrared spectroscopy. In the present study, the correlation between rScO2 and
      SvO2 was calculated during off-pump coronary artery bypass grafting surgery to
      determine whether a positive correlation exists between rScO2 and SvO2 . METHODS:
      A total of 56 subjects were consecutively enrolled in the study. Then rScO2 and
      SvO2 were simultaneously monitored. The parameters were recorded at 5 time
      points: T1, 10 min after intubation (1.0 FIO2 for 10 min); T2, 20 min after
      intubation (0.60 FIO2 for 10 min); T3, at the end of the revascularization of the
      left anterior descending artery (0.60 FIO2 ); T4, after protamine infusion (0.60
      FIO2 ); and T5, 10 min after protamine infusion (1.0 FIO2 for 10 min). The
      correlation between rScO2 and SvO2 and the variation trend between rScO2 and SvO2
      when FIO2 increased from 0.60 to 1.0 were analyzed. RESULTS: There was a
      significant positive correlation between rScO2 and SvO2 at these 5 time points (r
      2 = 0.77, 0.81, 0.70, 0.83, and 0.92, respectively). There also was a significant
      positive correlation between Delta rScO2 and Delta SvO2 (n = 112, r 2 = 0.72, P <
      .001). Linear regression analysis revealed that SvO2 had a positive correlation
      with rScO2 and cardiac output (r 2 = 0.68, P = .013). CONCLUSIONS: There was a
      positive correlation between rScO2 and SvO2 during off-pump coronary artery
      bypass grafting surgery, and there also was a positive correlation in the
      variation trend between rScO2 and SvO2 .

PMID- 29844214
TI  - The Effect of Different Closed Suction Catheter Designs and pMDI Adapters on
      Aerosol Delivery in Simulated Adult Mechanical Ventilation With and Without
      Exhaled Humidity.
AB  - BACKGROUND: Closed suction catheters are commonly used with pressurized metered
      dose inhalers (pMDIs) in ventilator-dependent patients receiving bronchodilator
      therapy. Although heated/humidified circuits result in a decrease in drug
      delivery, no studies have investigated the impact of a closed suction catheter
      with a pMDI on aerosol delivery during mechanical ventilation. We sought to
      quantify aerosol delivery with a variety of closed suction catheters and pMDI
      adapters in a simulated ventilator-dependent adult lung model with and without
      exhaled humidity. METHODS: A ventilator (tidal volume 450 mL, PEEP 5 cm H2O,
      breathing frequency 15 breaths/min, peak flow 60 L/min, and bias flow 2 L/min)
      was attached to 3 closed suction catheter designs (T-piece, double swivel elbow,
      and a multi-access port) with pMDI adapters (small- and large-unidirectional
      adapters, a bidirectional adapter, and a built-in port) connected to an
      endotracheal tube (ETT) with a collecting filter and a passive test lung. To
      simulate exhaled humidity, a heated humidifier was placed between the collection
      filter and the distal tip of the ETT, set at 36 degrees C. Experiments without
      exhaled humidity were performed with no heat and humidification. For each test, 4
      puffs of albuterol sulfate (432 MUg) were administered. The drug was eluted from
      the collecting filter and analyzed via spectrophotometer (276 nm). Each
      experiment was run 3 times. RESULTS: Delivery efficiency of the bidirectional
      adapter was greatest compared to other adapters tested in this study (P = .01).
      Aerosol deposition obtained from the combination of the T-piece closed suction
      catheter and the bidirectional adapter was more than that from the multi-access
      port (P = .42) and double swivel closed suction catheter (P = .27). Drug delivery
      without exhaled humidity exceeded values with exhaled humidity by 20-90% using
      the small unidirectional, large unidirectional, and bidirectional adapters (P =
      .01, P = .02 and P = .02, respectively). CONCLUSIONS: Closed suction catheter,
      pMDI spacer/adapters, and exhalation conditions have an impact on drug delivery
      during simulated adult mechanical ventilation. Aerosol delivery without exhaled
      humidity appears to report unrealistically high values in comparison to the more
      accurate values with simulated exhalation humidity.

PMID- 29844215
TI  - Comparison of Flow Resistance Characteristics and Placement of Two Endotracheal
      Tubes.
AB  - BACKGROUND: In a traditional endotracheal tube (ETT), there is a linear outward
      pull through its attachment to the ventilator tubing that leads to risk of
      accidental dislodgement. This study was conducted to assess the ETT flow
      characteristics and to evaluate providers' intubation experience using two ETT's
      in a simulated setting. METHODS: Respiratory pressure-volume dynamics for the 2
      ETTs were studied in a simulation laboratory by using 3 different flow settings
      and 2 different test lungs. The time taken for successful intubation on a
      mannikin was compared by direct observation of 33 separate intubation attempts by
      11 different providers. Comfort with intubation by using both tubes was assessed
      with a Likert scale- based survey. The potential increase in physical and
      cognitive work load of nurses and respiratory therapists was assessed by the NASA
      task load index. RESULTS: There were slightly lower average tidal volumes
      delivered with SecureTube compared with the standard tube at different peak
      inspiratory pressures. Similarly, the same tidal volume delivered with a
      different flow and bag compliance required slightly higher peak inspiratory
      pressure compared with the standard ETT. Among providers, there was no difference
      in the average time to intubate when using either tube. All survey respondents (N
      = 11) rated intubation attempts with the SecureTube to be very easy compared with
      the standard tube. The NASA task load index (N = 26) showed very low task loads
      on all the tasks. CONCLUSIONS: There was minimal impact on flow resistance on
      pressure or volume with the SecureTube compared with the standard tube. Most
      providers felt comfortable intubating with the SecureTube and took a comparable
      amount of time to intubate in a simulated setting. We observed low task load
      scores for securement, maintenance, and manipulation per nurses and respiratory
      therapists.

PMID- 29844216
TI  - Acute Effects of Mechanical Insufflation-Exsufflation on the Breathing Pattern in
      Stable Subjects With Duchenne Muscular Dystrophy.
AB  - BACKGROUND: Duchenne muscular dystrophy (DMD) is characterized by progressive
      degeneration, wasting, and weakness of skeletal musculature, including
      respiratory muscles. Cough is also compromised with disease progression. Among
      cough-augmentation techniques, mechanical insufflation-exsufflation (MI-E) has
      demonstrated several clinical benefits in patients with chronic airway secretion
      obstruction and muscular weakness. In clinical practice, the use of MI-E in DMD
      patients is also suggested when they are stable with no airway infections.
      However, there is a paucity of studies that consider the effect of MI-E
      specifically on stable DMD patients who have adapted to the use of MI-E. METHODS:
      Twenty subjects with DMD with no active upper airway or lung infections, who used
      MI-E device regularly at home, were enrolled. They received a single MI-E
      treatment consisting of 5 cycles of 5 insufflations-exsufflations with their
      customary settings. Volume variations during quiet breathing, vital capacity, and
      cough before and after treatment were measured with optoelectronic
      plethysmography (OEP). RESULTS: A decrease in breathing frequency (P = .001) and
      the rapid shallow breathing index emerged (P = .007), while cough peak flow
      (Spirometer P = .86, OEP P = .58), vital capacity (Spirometer P = .78, OEP total
      chest wall P = .57), and end-expiratory volumes (Total chest wall P = .97,
      Ribcage P = .14, Abdomen P = .10) were not affected by the treatment. An
      increment of the chest wall volume variation during the expiratory cough phase
      was identified (P = .001), particularly due to an increase in abdominal expansion
      (P = .005). CONCLUSIONS: A single treatment of MI-E in subjects with stable DMD
      already adapted to the device can provide beneficial changes in breathing pattern
      through a significant decrease in breathing frequency and rapid shallow
      breathing. These findings suggest an improvement in short-term dyspnea, although
      there were no changes in lung-volume recruitment or unassisted cough peak flow.

PMID- 29844218
TI  - Adaptive Immune Responses in Hepatitis A Virus and Hepatitis E Virus Infections.
AB  - Both hepatitis A virus (HAV) and hepatitis E virus (HEV) cause self-limited
      infections in humans that are preventable by vaccination. Progress in
      characterizing adaptive immune responses against these enteric hepatitis viruses,
      and how they contribute to resolution of infection or liver injury, has therefore
      remained largely frozen for the past two decades. How HAV and HEV infections are
      so effectively controlled by B- and T-cell immunity, and why they do not have the
      same propensity to persist as HBV and HCV infections, cannot yet be adequately
      explained. The objective of this review is to summarize our understanding of the
      relationship between patterns of virus replication, adaptive immune responses,
      and acute liver injury in HAV and HEV infections. Gaps in knowledge, and recent
      studies that challenge long-held concepts of how antibodies and T cells
      contribute to control and pathogenesis of HAV and HEV infections, are
      highlighted.

PMID- 29844219
TI  - Characterizing the Cancer Genome in Blood.
AB  - Cell-free circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) can be
      found in the bloodstream of individuals with cancer and are increasingly being
      explored as biomarkers in various aspects of cancer management. The application
      of next-generation sequencing (NGS) technologies to ctDNA and CTC analysis are
      providing new opportunities to characterize the cancer genome from a simple blood
      test and can facilitate the ease with which tumor-specific genomic changes can be
      followed over time. The serial analysis of ctDNA and CTCs has enormous potential
      to provide insights into intratumor heterogeneity and clonal evolution during
      disease progression, and may ultimately allow noninvasive molecular disease
      monitoring to guide therapeutic decisions and improve patient outcomes.

PMID- 29844220
TI  - Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models, and
      Therapies.
AB  - Although a de novo clinical presentation of small cell neuroendocrine carcinoma
      of the prostate is rare, a subset of patients previously diagnosed with prostate
      adenocarcinoma may develop neuroendocrine features in later stages of castration
      resistant prostate cancer (CRPC) progression as a result of treatment resistance.
      Despite sharing clinical, histologic, and some molecular features with other
      neuroendocrine carcinomas, including small cell lung cancer, castration-resistant
      neuroendocrine prostate cancer (CRPC-NE) is clonally derived from prostate
      adenocarcinoma. CRPC-NE therefore retains early prostate cancer genomic
      alterations and acquires new molecular changes making them resistant to
      traditional CRPC therapies. This review focuses on recent advances in our
      understanding of CRPC-NE biology, the transdifferentiation/plasticity process,
      and development and characterization of relevant CRPC-NE preclinical models.

PMID- 29844221
TI  - Molecular Composition of Vestibular Hair Bundles.
AB  - The vertebrate hair bundle, responsible for transduction of mechanical signals
      into receptor potentials in sensory hair cells, is an evolutionary masterpiece.
      Composed of actin-filled stereocilia of precisely regulated length, width, and
      number, the structure of the hair bundle is optimized for sensing auditory and
      vestibular stimuli. Recent developments in identifying the lipids and proteins
      constituting the hair bundle, obtained through genetics, biochemistry, and
      imaging, now permit a description of the consensus composition of vestibular
      bundles of mouse, rat, and chick.

PMID- 29844217
TI  - The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not
      metformin, prevents inflammation-associated cachectic muscle wasting.
AB  - Activation of AMPK has been associated with pro-atrophic signaling in muscle.
      However, AMPK also has anti-inflammatory effects, suggesting that in cachexia, a
      syndrome of inflammatory-driven muscle wasting, AMPK activation could be
      beneficial. Here we show that the AMPK agonist AICAR suppresses IFNgamma/TNFalpha
      induced atrophy, while the mitochondrial inhibitor metformin does not.
      IFNgamma/TNFalpha impair mitochondrial oxidative respiration in myotubes and
      promote a metabolic shift to aerobic glycolysis, similarly to metformin. In
      contrast, AICAR partially restored metabolic function. The effects of AICAR were
      prevented by the AMPK inhibitor Compound C and were reproduced with A-769662, a
      specific AMPK activator. AICAR and A-769662 co-treatment was found to be
      synergistic, suggesting that the anti-cachectic effects of these drugs are
      mediated through AMPK activation. AICAR spared muscle mass in mouse models of
      cancer and LPS induced atrophy. Together, our findings suggest a dual function
      for AMPK during inflammation-driven atrophy, wherein it can play a protective
      role when activated exogenously early in disease progression, but may contribute
      to anabolic suppression and atrophy when activated later through mitochondrial
      dysfunction and subsequent metabolic stress.

PMID- 29844222
TI  - The Role of Next-Generation Sequencing in Pharmacogenetics and Pharmacogenomics.
AB  - Inherited genetic variations in pharmacogenetic loci are widely acknowledged as
      important determinants of phenotypic differences in drug response, and may be
      actionable in the clinic. However, recent studies suggest that a considerable
      number of novel rare variants in pharmacogenes likely contribute to a still
      unexplained fraction of the observed interindividual variability. Next-generation
      sequencing (NGS) represents a rapid, relatively inexpensive, large-scale DNA
      sequencing technology with potential relevance as a comprehensive pharmacogenetic
      genotyping platform to identify genetic variation related to drug therapy.
      However, many obstacles remain before the clinical use of NGS-based test results,
      including technical challenges, functional interpretation, and strict
      requirements for diagnostic tests. Advanced computational analyses, high
      throughput screening methodologies, and generation of shared resources with cell
      based and clinical information will facilitate the integration of NGS data into
      candidate genotyping approaches, likely enhancing future drug phenotype
      predictions in patients.

PMID- 29844223
TI  - Whole-Genome Sequencing in Cancer.
AB  - Genome sequencing of cancer has fundamentally advanced our understanding of the
      underlying biology of this disease, and more recently has provided approaches to
      characterize and monitor tumors in the clinic, guiding and evaluating treatment.
      Although cancer research is relying more on whole-genome characterization, the
      clinical application of genomics is largely limited to targeted sequencing
      approaches, tailored to capture specific clinically relevant biomarkers. However,
      as sequencing costs reduce, and the tools to effectively analyze complex and
      large-scale data improve, the ability to effectively characterize whole genomes
      at scale in a clinically relevant time frame is now being piloted. This ability
      effectively blurs the line between clinical cancer research and the clinical
      management of the disease. This leads to a new paradigm in cancer management in
      which real-time analysis of an individual's disease can have a rapid and lasting
      impact on our understanding of how clinical practices need to change to exploit
      novel therapeutic rationales. In this article, we will discuss how whole-genome
      sequencing (WGS), often combined with transcriptome analysis, has been used to
      understand cancer and how this approach is uniquely positioned to provide a
      comprehensive view of an evolving disease in response to therapy.

PMID- 29844225
TI  - Effects of micronutrients on placental function: evidence from clinical studies
      to animal models.
AB  - Micronutrient deficiencies are common in pregnant women due to low dietary intake
      and increased requirements for fetal development. Low maternal micronutrient
      status is associated with a range of pregnancy pathologies involving placental
      dysfunction, including fetal growth restriction (FGR), small-for-gestational age
      (SGA), pre-eclampsia and preterm birth. However, clinical trials commonly fail to
      convincingly demonstrate beneficial effects of supplementation of individual
      micronutrients, attributed to heterogeneity and insufficient power, potential
      interactions and lack of mechanistic knowledge of effects on the placenta. We
      aimed to provide current evidence of relationships between selected
      micronutrients (vitamin D, vitamin A, iron, folate, vitamin B12) and adverse
      pregnancy outcomes, combined with understanding of actions on the placenta.
      Following a systematic literature search, we reviewed data from clinical, in
      vitro and in vivo studies of micronutrient deficiency and supplementation. Key
      findings are potential effects of micronutrient deficiencies on placental
      development and function, leading to impaired fetal growth. Studies in human
      trophoblast cells and rodent models provide insights into underpinning
      mechanisms. Interestingly, there is emerging evidence that deficiencies in all
      micronutrients examined induce a pro-inflammatory state in the placenta, drawing
      parallels with the inflammation detected in FGR, pre-eclampsia, stillbirth and
      preterm birth. Beneficial effects of supplementation are apparent in vitro and in
      animal models and for combined micronutrients in clinical studies. However,
      greater understanding of the roles of these micronutrients, and insight into
      their involvement in placental dysfunction, combined with more robust clinical
      studies, is needed to fully ascertain the potential benefits of supplementation
      in pregnancy.

PMID- 29844226
TI  - Peri-ovarian adipose tissue contributes to intraovarian control during
      folliculogenesis in mice.
AB  - Peri-ovarian adipose tissue (POAT) is a kind of intra-abdominal white adipose
      tissue that is present surrounding the ovaries in rodents. Recent studies
      demonstrated that POAT-deficient mice displayed a phenotype of delayed antral
      follicular development, for which decreases in serum estrogen, serum FSH and FSHR
      levels were responsible. However, folliculogenesis is regulated by endocrine
      signals and also modulated by a number of locally produced intraovarian factors
      whose acts are both autocrine and paracrine. Here, we used a model of surgical
      removal of POAT unilaterally and contralateral ovaries as controls, as both were
      under the same endocrine control, to assess the paracrine effect of the POAT on
      folliculogenesis. Surgical removal of unilateral POAT resulted in delayed antral
      follicular development and the increased number of atretic follicles, accompanied
      by decreased levels of intraovarian adipokines and growth factors, lipid
      accumulation and steroidogenic enzyme expression. POAT-deficient ovaries
      displayed compensatory increased expressions of intraovarian genes, such as Vegf
      and Adpn for angiogenesis, Acc, Fasn, and Gapdh involved in lipogenesis and Fshr
      in response to FSH stimulation. Furthermore, we demonstrated that removal of POAT
      promoted follicular apoptosis, caused retention of cytoplasmic YAP and inhibited
      PTEN-AKT-mTOR activation. These alterations were observed only in the POAT
      deficient ovaries but not in the contralateral ovaries (with POAT), which
      suggests that a paracrine interaction between POAT and ovaries is important for
      normal folliculogenesis.

PMID- 29844224
TI  - Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in
      Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in
      Communities Study.
AB  - Fructosamine and glycated albumin are potentially useful alternatives to
      hemoglobin A1c (HbA1c) as diabetes biomarkers. The genetic determinants of
      fructosamine and glycated albumin, however, are unknown. We performed genome-wide
      association studies of fructosamine and glycated albumin among 2,104 black and
      7,647 white participants without diabetes in the Atherosclerosis Risk in
      Communities (ARIC) Study and replicated findings in the Coronary Artery Risk
      Development in Young Adults (CARDIA) study. Among whites, rs34459162, a novel
      missense single nucleotide polymorphism (SNP) in RCN3, was associated with
      fructosamine (P = 5.3 * 10-9) and rs1260236, a known diabetes-related missense
      mutation in GCKR, was associated with percent glycated albumin (P = 5.9 * 10-9)
      and replicated in CARDIA. We also found two novel associations among blacks: an
      intergenic SNP, rs2438321, associated with fructosamine (P = 6.2 * 10-9), and an
      intronic variant in PRKCA, rs59443763, associated with percent glycated albumin
      (P = 4.1 * 10-9), but these results did not replicate. Few established fasting
      glucose or HbA1c SNPs were also associated with fructosamine or glycated albumin.
      Overall, we found genetic variants associated with the glycemic information
      captured by fructosamine and glycated albumin as well as with their nonglycemic
      component. This highlights the importance of examining the genetics of
      hyperglycemia biomarkers to understand the information they capture, including
      potential glucose-independent factors.

PMID- 29844227
TI  - Candidate Enzymes for Saffron Crocin Biosynthesis Are Localized in Multiple
      Cellular Compartments.
AB  - Saffron is the dried stigmas of Crocus sativus and is the most expensive spice in
      the world. Its red color is due to crocins, which are apocarotenoid glycosides
      that accumulate in the vacuole to a level up to 10% of the stigma dry weight.
      Previously, we characterized the first dedicated enzyme in the crocin
      biosynthetic pathway, carotenoid cleavage dioxygenase2 (CsCCD2), which cleaves
      zeaxanthin to yield crocetin dialdehyde. In this work, we identified six putative
      aldehyde dehydrogenase (ALDH) genes expressed in C. sativus stigmas. Heterologous
      expression in Escherichia coli showed that only one of corresponding proteins
      (CsALDH3I1) was able to convert crocetin dialdehyde into the crocin precursor
      crocetin. CsALDH3I1 carries a carboxyl-terminal hydrophobic domain, similar to
      that of the Neurospora crassa membrane-associated apocarotenoid dehydrogenase YLO
      1. We also characterized the UDP-glycosyltransferase CsUGT74AD1, which converts
      crocetin to crocins 1 and 2'. In vitro assays revealed high specificity of
      CsALDH3I1 for crocetin dialdehyde and long-chain apocarotenals and of CsUGT74AD1
      for crocetin. Following extract fractionation, CsCCD2, CsALDH3I1, and CsUGT74AD1
      were found in the insoluble fraction, suggesting their association with membranes
      or large insoluble complexes. Analysis of protein localization in both C. sativus
      stigmas and following transgene expression in Nicotiana benthamiana leaves
      revealed that CsCCD2, CsALDH3I, and CsUGT74AD1 were localized to the plastids,
      the endoplasmic reticulum, and the cytoplasm, respectively, in association with
      cytoskeleton-like structures. Based on these findings and current literature, we
      propose that the endoplasmic reticulum and cytoplasm function as transit centers
      for metabolites whose biosynthesis starts in the plastid and are accumulated in
      the vacuole.

PMID- 29844228
TI  - Asexual Female Gametogenesis Involves Contact with a Sexually-Fated Megaspore in
      Apomictic Hieracium.
AB  - Apomixis results in asexual seed formation where progeny are identical to the
      maternal plant. In ovules of apomictic species of the Hieracium subgenus
      Pilosella, meiosis of the megaspore mother cell generates four megaspores.
      Aposporous initial (AI) cells form during meiosis in most ovules. The sexual
      pathway terminates during functional megaspore (FM) differentiation, when an
      enlarged AI undergoes mitosis to form an aposporous female gametophyte. Then, the
      mitotically programmed FM dies along with the three other megaspores by unknown
      mechanisms. Transcriptomes of laser-dissected AIs, ovule cells, and ovaries from
      apomicts and AI-deficient mutants were analyzed to understand the pathways
      involved. The steps leading to AI mitosis and sexual pathway termination were
      determined using antibodies against arabinogalactan protein epitopes found to
      mark both sexual and aposporous female gametophyte lineages at inception. At
      most, four AIs differentiated near developing megaspores. The first expanding AI
      cell to contact the FM formed a functional AI that underwent mitosis soon after
      megaspore degeneration. Transcriptome analyses indicated that the enlarged, laser
      captured AIs were arrested in the S/G2 phase of the cell cycle and were
      metabolically active. Further comparisons with AI-deficient mutants showed that
      AIs were enriched in transcripts encoding homologs of genes involved in, and
      potentially antagonistic to, known FM specification pathways. We propose that AI
      and FM cell contact provides cues required for AI mitosis and megaspore
      degeneration. Specific candidates to further interrogate AI-FM interactions were
      identified here and include Hieracium arabinogalactan protein family genes.

PMID- 29844229
TI  - Reproductive Long Intergenic Noncoding RNAs Exhibit Male Gamete Specificity and
      Polycomb Repressive Complex 2-Mediated Repression.
AB  - Long noncoding RNAs (lncRNAs) have been characterized extensively in animals and
      are involved in several processes, including homeobox gene expression and X
      chromosome inactivation. In comparison, there has been much less detailed
      characterization of plant lncRNAs, and the number of distinct lncRNAs encoded in
      plant genomes and their regulation by developmental and epigenetic mechanisms
      remain largely unknown. Here, we analyzed transcriptome data from Asian rice
      (Oryza sativa) and identified 6,309 long intergenic noncoding RNAs (lincRNAs),
      focusing on their expression in reproductive tissues and organs. Most O. sativa
      lincRNAs were expressed in a highly tissue-specific manner, with an unexpectedly
      high fraction specifically expressed in male gametes. Mutation of a component of
      the Polycomb Repressive Complex2 (PRC2) resulted in derepression of another large
      class of lincRNAs, whose expression is correlated with H3K27 trimethylation in
      developing panicles. Overlap with the sperm cell-specific lincRNAs suggests that
      epigenetic repression of lincRNAs in the panicles was partially relieved in the
      male germline. Expression of a subset of lincRNAs also showed modulation by
      drought in reproductive tissues. Comparison with other cereal genomes showed that
      the lincRNAs generally have low levels of conservation at both the sequence and
      structural levels. Use of a novelty detection support vector machine model
      enabled the detection of nucleotide sequence and structural homology in ~10% and
      ~4% of the lincRNAs in genomes of purple false brome (Brachypodium distachyon)
      and maize (Zea mays), respectively. This is the first study to report on a large
      number of lncRNAs that are targets of repression by PRC2 rather than mediating
      regulation via PRC2. That the vast majority of the lincRNAs reported here do not
      overlap with those of other rice studies indicates that these are a significant
      addition to the known lincRNAs in rice.

PMID- 29844230
TI  - Standardisation of perioperative urinary catheter use to reduce postsurgical
      urinary tract infection: an interrupted time series study.
AB  - BACKGROUND: Prevention of healthcare-associated urinary tract infection (UTI) has
      been the focus of a national effort, yet appropriate indications for insertion
      and removal of urinary catheters (UC) among surgical patients remain poorly
      defined. METHODS: We developed and implemented a standardised approach to
      perioperative UC use to reduce postsurgical UTI including standard criteria for
      catheter insertion, training of staff to insert UC using sterile technique and
      standardised removal in the operating room and surgical unit using a nurse
      initiated medical directive. We performed an interrupted time series analysis up
      to 2 years following intervention. The primary outcome was the proportion of
      patients who developed postsurgical UTI within 30 days as measured by the
      American College of Surgeons National Surgical Quality Improvement Program (ACS
      NSQIP). Process measures included monthly UC insertions, removals in the
      operating room and UC days per patient-days on surgical units. RESULTS: At
      baseline, 22.5% of patients were catheterised for surgery, none were removed in
      the operating room and catheter-days per patient-days were 17.4% on surgical
      units. Following implementation of intervention, monthly catheter removal in the
      operating room immediately increased (range 12.2%-30.0%) while monthly UC
      insertion decreased more slowly before being sustained below baseline for 12
      months (range 8.4%-15.6%). Monthly catheter-days per patient-days decreased to
      8.3% immediately following intervention with a sustained shift below the mean in
      the final 8 months. Postsurgical UTI decreased from 2.5% (95% CI 2.0-3.1%) to
      1.4% (95% CI 1.1-1.9; p=0.002) during the intervention period. CONCLUSIONS:
      Standardised perioperative UC practices resulted in measurable improvement in
      postsurgical UTI. These appropriateness criteria for perioperative UC use among a
      broad range of surgical services could inform best practices for hospitals
      participating in ACS NSQIP.

PMID- 29844231
TI  - Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon
      Tetrachloride-Induced Model of Liver Injury.
AB  - The cyclooxygenase-2 (COX-2) selective inhibitor celecoxib is widely used in the
      treatment of pain and inflammation. Celecoxib has been explored as a possible
      treatment of liver fibrosis with contradictory results, depending on the model.
      The present study reports the effect of celecoxib in a 5-week carbon
      tetrachloride (CCl4)-induced liver fibrosis mouse model. Celecoxib alone and in
      combination with inhibitors of the enzyme-soluble epoxide hydrolase (sEH), as
      well as a dual inhibitor that targets both COX-2 and sEH, were administered via
      osmotic minipump to mice receiving intraperitoneal injections of CCl4 Collagen
      deposition was elevated in the mice treated with both celecoxib and CCl4 compared
      with the control or CCl4-only groups, as assessed by trichrome staining.
      Histopathology revealed more extensive fibrosis and cell death in the animals
      treated with both celecoxib and CCl4 compared with all other experimental groups.
      Although some markers of fibrosis, such as matrix metalloprotease, were unchanged
      or lowered in the animals treated with both celecoxib and CCl4, overall, hepatic
      fibrosis was more severe in this group. Cotreatment with celecoxib and an
      inhibitor of sEH or treatment with a dual inhibitor of COX-2 and sEH decreased
      the elevated levels of fibrotic markers observed in the group that received both
      celecoxib and CCl4 Oxylipid analysis revealed that celecoxib reduced the level of
      prostaglandin E2 relative to the CCl4 only group. Overall, celecoxib treatment
      did not decrease liver fibrosis in CCl4-treated mice.

PMID- 29844232
TI  - Biochemical Characterization of Isoniazid-resistant Mycobacterium tuberculosis:
      Can the Analysis of Clonal Strains Reveal Novel Targetable Pathways?
AB  - Tuberculosis (TB) continues to be an important public health threat worldwide,
      due in part to drug resistant Mycobacterium tuberculosis (Mtb) strains. The
      United States recently reported a shortage of isoniazid (INH), which could drive
      higher INH resistance rates. Changes in the Mtb proteome before and after
      acquisition of INH resistance in a clean genetic background remain understudied
      and may elucidate alternate drug targets. Here, we focused on Mtb clonal strains
      to characterize the consequences of INH resistance on mycobacterial metabolism.
      Proteomic analysis was conducted by liquid-chromatography tandem mass
      spectrometry (LC-MS/MS) of cellular and secreted fractions, followed by a
      normalized spectral counting (NSAF) analysis (data are available via
      ProteomeXchange with identifier PXD009549). Two different Mtb clonal pairs
      representing a specific genetic lineage (one clinical and one generated in the
      laboratory) but sharing a katG mutation associated with INH resistance, were used
      in our analysis. Overall, we found 26 Mtb proteins with altered abundances after
      acquisition of INH resistance across both Mtb genetic lineages studied. These
      proteins were involved in ATP synthesis, lipid metabolism, regulatory events, and
      virulence, detoxification, and adaptation processes. Proteomic findings were
      validated by Western blotting analyses whenever possible. Mycolic acid (MA)
      analysis through LC/MS in the clonal Mtb pairs did not reveal a common trend in
      the alteration of these fatty acids across both INHr strains but revealed a
      significant reduction in levels of the two more abundant alpha-MA features in the
      clinical INHr strain. Interestingly, the clinical clonal pair demonstrated more
      variation in the abundance of the proteins involved in the FAS II pathway.
      Together, the proteomic and lipidomic data highlight the identification of
      potential drug targets such as alternative lipid biosynthetic pathways that may
      be exploited to combat clinically relevant Mtb INHr strains.

PMID- 29844233
TI  - Interleukin-21 Induces Short-Lived Effector CD8+ T Cells but Does Not Inhibit
      Their Exhaustion after Mycobacterium bovis BCG Infection in Mice.
AB  - Interleukin 21 (IL-21) is a pleiotropic common cytokine receptor gamma chain
      cytokine that promotes the effector functions of NK cells and CD8+ T cells and
      inhibits CD8+ T cell exhaustion during chronic infection. We found that the
      absolute number of short-lived effector CD8+ T cells (SLECs) (KLRG1high CD127low)
      decreased significantly in IL-21 receptor-deficient (IL-21R-/-) mice during
      Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection. Early effector CD8+
      T cells (EECs) (KLRG1low CD127low) were normally generated in IL-21R-/- mice
      after infection. Exhausted CD8+ T cells (PD-1high KLRG1low) were also normally
      generated in IL-21R-/- mice after infection. Mixed bone marrow (BM) chimera and
      transfer experiments showed that IL-21R on CD8+ T cells was essential for the
      proliferation of EECs, allowing them to differentiate into SLECs after BCG
      infection. On the other hand, the number of SLECs increased significantly after
      infection with recombinant BCG (rBCG) that secreted an antigen 85B (Ag85B)-IL-21
      fusion protein (rBCG-Ag85B-IL-21), but the number of exhausted CD8+ T cells did
      not change after rBCG-Ag85B-IL-21 infection. These results suggest that IL-21
      signaling drives the differentiation of SLECs from EECs but does not inhibit the
      exhaustion of CD8+ T cells following BCG infection in mice.

PMID- 29844234
TI  - Spatial, Temporal, and Functional Assessment of LC3-Dependent Autophagy in
      Shigella flexneri Dissemination.
AB  - Shigella flexneri disseminates within the colonic mucosa by displaying actin
      based motility in the cytosol of epithelial cells. Motile bacteria form membrane
      protrusions that project into adjacent cells and resolve into double-membrane
      vacuoles (DMVs) from which the bacteria escape, thereby achieving cell-to-cell
      spread. During dissemination, S. flexneri is targeted by LC3-dependent autophagy,
      a host cell defense mechanism against intracellular pathogens. The S. flexneri
      type III secretion system effector protein IcsB was initially proposed to
      counteract the recruitment of the LC3-dependent autophagy machinery to cytosolic
      bacteria. However, a recent study proposed that LC3 was recruited to bacteria in
      DMVs formed during cell-to-cell spread. To resolve the controversy and clarify
      the role of autophagy in S. flexneri infection, we tracked dissemination using
      live confocal microscopy and determined the spatial and temporal recruitment of
      LC3 to bacteria. This approach demonstrated that (i) LC3 was exclusively
      recruited to wild-type or icsB bacteria located in DMVs and (ii) the icsB mutant
      was defective in cell-to-cell spread due to failure to escape LC3-positive as
      well as LC3-negative DMVs. Failure of S. flexneri to escape DMVs correlated with
      late LC3 recruitment, suggesting that LC3 recruitment is the consequence and not
      the cause of DMV escape failure. Inhibition of autophagy had no positive impact
      on the spreading of wild-type or icsB mutant bacteria. Our results unambiguously
      demonstrate that IcsB is required for DMV escape during cell-to-cell spread,
      regardless of LC3 recruitment, and do not support the previously proposed notion
      that autophagy counters S. flexneri dissemination.

PMID- 29844235
TI  - Phosphatidylinositol-(3,4,5)-Trisphosphate Induces Phagocytosis of Nonmotile
      Pseudomonas aeruginosa.
AB  - Pathogenic bacteria that establish chronic infections in immunocompromised
      patients frequently undergo adaptation or selection for traits that are
      advantageous for their growth and survival. Clinical isolates of Pseudomonas
      aeruginosa, a Gram-negative, opportunistic bacterial pathogen, exhibit a temporal
      transition from a motile to a nonmotile phenotype through loss of flagellar
      motility during the course of chronic infection. This progressive loss of
      motility is associated with increased resistance to both antibiotic and immune
      clearance. We have previously shown that loss of bacterial motility enables P.
      aeruginosa to evade phagocytic clearance both in vitro and in vivo and fails to
      activate the phosphatidylinositol 3-kinase (PI3K)/Akt-dependent phagocytic
      pathway. Therefore, we tested the hypothesis that clearance of phagocytosis
      resistant bacteria could be induced by exogenously pretreating innate immune
      cells with the Akt-activating molecule phosphatidylinositol-(3,4,5)-trisphosphate
      (PIP3). Here, we demonstrate that PIP3 induces the uptake of nonmotile P.
      aeruginosa by primary human neutrophils >25-fold, and this effect is phenocopied
      with the use of murine phagocytes. However, surprisingly, mechanistic studies
      revealed that the induction of phagocytosis by PIP3 occurs because
      polyphosphoinositides promote bacterial binding by the phagocytes rather than
      bypassing the requirement for PI3K. Moreover, this induction was selective since
      the uptake of other nonmotile Gram-negative, but not Gram-positive, bacteria can
      also be induced by PIP3 Since there is currently no treatment that effectively
      eradicates chronic P. aeruginosa infections, these findings provide novel
      insights into a potential methodology by which to induce clearance of nonmotile
      pathogenic bacteria and into the endogenous determinants of phagocytic
      recognition of P. aeruginosa.

PMID- 29844236
TI  - Intestinal Lamina Propria CD4+ T Cells Promote Bactericidal Activity of
      Macrophages via Galectin-9 and Tim-3 Interaction during Salmonella enterica
      Serovar Typhimurium Infection.
AB  - The intestinal immune system is crucial for protection from pathogenic infection
      and maintenance of mucosal homeostasis. We studied the intestinal immune
      microenvironment in a Salmonella enterica serovar Typhimurium intestinal
      infection mouse model. Intestinal lamina propria macrophages are the main
      effector cells in innate resistance to intracellular microbial pathogens. We
      found that S Typhimurium infection augmented Tim-3 expression on intestinal
      lamina propria CD4+ T cells and enhanced galectin-9 expression on F4/80+ CD11b+
      macrophages. Moreover, CD4+ T cells promoted the activation and bactericidal
      activity of intestinal F4/80+ CD11b+ macrophages via the Tim-3/galectin-9
      interaction during S Typhimurium infection. Blocking the Tim-3/galectin-9
      interaction with alpha-lactose significantly attenuated the bactericidal activity
      of intracellular S Typhimurium by macrophages. Furthermore, the Tim-3/galectin-9
      interaction promoted the formation and activation of inflammasomes, which led to
      caspase-1 cleavage and interleukin 1beta (IL-1beta) secretion. The secretion of
      active IL-1beta further improved bactericidal activity of macrophages and
      galectin-9 expression on macrophages. These results demonstrated the critical
      role of the cross talk between CD4+ T cells and macrophages, particularly the Tim
      3/galectin-9 interaction, in antimicrobial immunity and the control of intestinal
      pathogenic infections.

PMID- 29844237
TI  - A Novel Sialylation Site on Neisseria gonorrhoeae Lipooligosaccharide Links
      Heptose II Lactose Expression with Pathogenicity.
AB  - Sialylation of lacto-N-neotetraose (LNnT) extending from heptose I (HepI) of
      gonococcal lipooligosaccharide (LOS) contributes to pathogenesis. Previously,
      gonococcal LOS sialyltransterase (Lst) was shown to sialylate LOS in Triton X-100
      extracts of strain 15253, which expresses lactose from both HepI and HepII, the
      minimal structure required for monoclonal antibody (MAb) 2C7 binding. Ongoing
      work has shown that growth of 15253 in cytidine monophospho-N-acetylneuraminic
      acid (CMP-Neu5Ac)-containing medium enables binding to CD33/Siglec-3, a cell
      surface receptor that binds sialic acid, suggesting that lactose termini on LOSs
      of intact gonococci can be sialylated. Neu5Ac was detected on LOSs of strains
      15253 and an MS11 mutant with lactose only from HepI and HepII by mass
      spectrometry; deleting HepII lactose rendered Neu5Ac undetectable. Resistance of
      HepII lactose Neu5Ac to desialylation by alpha2-3-specific neuraminidase
      suggested an alpha2-6 linkage. Although not associated with increased factor H
      binding, HepII lactose sialylation inhibited complement C3 deposition on
      gonococci. Strain 15253 mutants that lacked Lst or HepII lactose were
      significantly attenuated in mice, confirming the importance of HepII Neu5Ac in
      virulence. All 75 minimally passaged clinical isolates from Nanjing, China,
      expressed HepII lactose, evidenced by reactivity with MAb 2C7; MAb 2C7 was
      bactericidal against the first 62 (of 75) isolates that had been collected
      sequentially and were sialylated before testing. MAb 2C7 effectively attenuated
      15253 vaginal colonization in mice. In conclusion, this novel sialylation site
      could explain the ubiquity of gonococcal HepII lactose in vivo Our findings
      reinforce the candidacy of the 2C7 epitope as a vaccine antigen and MAb 2C7 as an
      immunotherapeutic antibody.

PMID- 29844238
TI  - The Periplasmic Trehalase Affects Type 1 Fimbria Production and Virulence of
      Extraintestinal Pathogenic Escherichia coli Strain MT78.
AB  - Extraintestinal pathogenic Escherichia coli (ExPEC) is responsible for various
      infections outside the gastrointestinal tract in humans and other animals. ExPEC
      strain MT78 is invasive to various nonphagocytic cells and highly virulent in
      vivo To identify genes required for invasion of nonphagocytic cells by this
      strain, we applied signature-tagged mutagenesis to generate a library of mutants
      and tested them for invasion of avian fibroblasts. Mutants showing reduced
      cellular invasion included those with insertions in the fim operon, encoding type
      1 fimbriae. Another attenuated mutant showed a disruption in the treA gene, which
      encodes a periplasmic trehalase. The substrate of TreA, trehalose, can be
      metabolized and used as a carbon source or can serve as an osmoprotectant under
      conditions of osmotic stress in E. coli K-12. We generated and characterized
      mutant MT78DeltatreA In contrast to the wild type, MT78DeltatreA was able to grow
      under osmotic stress caused by 0.6 M urea but not in minimal M9 medium with
      trehalose as the only carbon source. It presented decreased association and
      invasion of avian fibroblasts, decreased yeast agglutination titer, and impaired
      type 1 fimbria production. In a murine model of urinary tract infection,
      MT78DeltatreA was less able to colonize the bladder. All phenotypes were rescued
      in the complemented mutant. Our results show that the treA gene is needed for
      optimal production of type 1 fimbriae in ExPEC strain MT78 and that loss of treA
      significantly reduces its cell invasion capacity and colonization of the bladder
      in a murine model of urinary tract infection.

PMID- 29844239
TI  - The Fructose-Specific Phosphotransferase System of Klebsiella pneumoniae Is
      Regulated by Global Regulator CRP and Linked to Virulence and Growth.
AB  - Klebsiella pneumoniae is an opportunistic pathogen, and its hypervirulent
      variants cause serious invasive community-acquired infections. A genomic view of
      K. pneumoniae NTUH-2044 for the carbohydrate phosphotransferase system (PTS)
      found a putative fructose PTS, namely, the Frw PTS gene cluster. The deletion
      mutant and the complemented mutant of frwC (KP1_1992), which encodes the putative
      fructose-specific enzyme IIC, were constructed, and the phenotypes were
      characterized. This transmembrane PTS protein is responsible for fructose
      utilization. frwC deletion can enhance biofilm formation and capsular
      polysaccharide (CPS) biosynthesis but decreases the growth rate and lethality in
      mice. frwC expression was repressed in the cyclic AMP receptor protein (CRP)
      mutant. Electrophoretic mobility shift assay showed that CRP can directly bind to
      the promoter of frwC These results indicated that frwC expression is controlled
      by CRP directly and that such regulation contributes to bacterial growth, CPS
      synthesis, and the virulence of the Deltacrp strain. The findings help elucidate
      fructose metabolism and the CRP regulatory mechanism in K. pneumoniae.

PMID- 29844240
TI  - Transposon Sequencing of Brucella abortus Uncovers Essential Genes for Growth In
      Vitro and Inside Macrophages.
AB  - Brucella abortus is a class III zoonotic bacterial pathogen able to survive and
      replicate inside host cells, including macrophages. Here we report a
      multidimensional transposon sequencing analysis to identify genes essential for
      Brucella abortus growth in rich medium and replication in RAW 264.7 macrophages.
      The construction of a dense transposon mutant library and mapping of 929,769
      unique mini-Tn5 insertion sites in the genome allowed identification of 491
      essential coding sequences and essential segments in the B. abortus genome.
      Chromosome II carries a lower proportion (5%) of essential genes than chromosome
      I (19%), supporting the hypothesis of a recent acquisition of a megaplasmid as
      the origin of chromosome II. Temporally resolved transposon sequencing analysis
      as a function of macrophage infection stages identified 79 genes with a specific
      attenuation phenotype in macrophages, at either 2, 5, or 24 h postinfection, and
      86 genes for which the attenuated mutant phenotype correlated with a growth
      defect on plates. We identified 48 genes required for intracellular growth,
      including the virB operon, encoding the type IV secretion system, which supports
      the validity of the screen. The remaining genes encode amino acid and pyrimidine
      biosynthesis, electron transfer systems, transcriptional regulators, and
      transporters. In particular, we report the need of an intact pyrimidine
      nucleotide biosynthesis pathway in order for B. abortus to proliferate inside RAW
      264.7 macrophages.

PMID- 29844241
TI  - TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile
      Infection.
AB  - Tumor progression locus 2 (TPL2), a serine/threonine protein kinase, is a major
      inflammatory mediator in immune cells. The predominant inflammatory actions of
      TPL2 depend on the activation of mitogen-activated protein kinases (MAPK) and the
      upregulated production of the cytokines tumor necrosis factor alpha (TNF-alpha)
      and interleukin 1beta (IL-1beta) in macrophages and dendritic cells in response
      to lipopolysaccharide (LPS). Significant increases in TNF-alpha, IL-6, IL-beta,
      and IL-8 levels in patients with Clostridium difficile infection (CDI) have been
      reported. Both TNF-alpha and IL-6 have been postulated to play key roles in the
      systemic inflammatory response in CDI, and IL-8 is essential for the development
      of local intestinal inflammatory responses in CDI. The objective of this study
      was to elucidate the role of TPL2 in the pathogenesis of CDI. We found that TPL2
      was significantly activated in human and mouse intestinal tissues upon C.
      difficile toxin exposure or CDI. We further demonstrated that TPL2 knockout (TPL2
      KO) mice were significantly more resistant to CDI than wild-type mice, with
      significantly reduced production of TNF-alpha, IL-6, IL-1beta, KC (a mouse
      homologue of IL-8), and myeloperoxidase (MPO) in the ceca and colons of TPL2-KO
      mice. Finally, we found that TPL2 inhibition by a specific inhibitor or TPL2 gene
      ablation significantly reduced TcdB-induced production of TNF-alpha, IL-6, IL
      beta, and KC by inhibiting the activation of p38, extracellular signal-regulated
      kinase (ERK), and c-Jun NH2-terminal kinase (JNK). Taken together, our data
      suggest that TPL2 represents a potential therapeutic target for CDI treatment.

PMID- 29844242
TI  - A Thioredoxin Homologous Protein of Plasmodium falciparum Participates in
      Erythrocyte Invasion.
AB  - Invasion of erythrocytes by merozoites is required in the life cycle of malarial
      parasites. Proteins derived from the invasive merozoites are essential ligands
      for erythrocyte recognition and penetration. In this study, we report a novel
      protein that possesses a Trx domain-like structure of the thioredoxin family and
      is expressed on the surface of merozoites of the malaria parasite Plasmodium
      falciparum This protein, namely, PfTrx-mero protein, displayed a mutated sequence
      character at the Trx domain, but with a specific binding activity to human
      erythrocytes. Specific antibodies to the protein inhibited merozoite invasion
      into human erythrocytes. Immunization with a homologous protein of Plasmodium
      berghei strain ANKA also showed significant protection against lethal infection
      in mice. These results suggested that the novel PfTrx-like-mero protein expressed
      on the surface of merozoites is an important ligand participating in erythrocyte
      invasion and a potential vaccine candidate.

PMID- 29844243
TI  - Toll-Like Receptor 2 and Lipoprotein-Like Lipoproteins Enhance Staphylococcus
      aureus Invasion in Epithelial Cells.
AB  - Staphylococcus aureus contains a certain subclass of lipoproteins, the so-called
      lipoprotein-like lipoproteins (Lpl's), that not only represent Toll-like receptor
      2 (TLR2) ligands but are also involved in host cell invasion. Here we addressed
      the question of which factors contribute to Lpl-mediated invasion of epithelial
      cells and keratinocytes. For this purpose, we compared the invasiveness of USA300
      and its Deltalpl mutant under different conditions. In the presence of the matrix
      proteins IgG, fibrinogen (Fg), and fibronectin (Fn), and of fetal bovine serum
      (FBS), the invasion ratio was increased in both strains, and always more in
      USA300 than in its Deltalpl mutant. Interestingly, when we compared the invasion
      of HEK-0 and HEK-TLR2 cells, the cells expressing TLR2 showed a 9-times-higher
      invasion frequency. When HEK-TLR2 cells were additionally stimulated with a
      synthetic lipopeptide, Pam3CSK4 (P3C), the invasion frequency was further
      increased. A potential reason for the positive effect of TLR2 on invasion could
      be that TLR2 activation by P3C also activates F-actin formation. Here we show
      that S. aureus invasion depends on a number of factors, on the host side as well
      as on the bacterial side.

PMID- 29844245
TI  - Sex-Specific Versus Overall Clinical Decision Limits for Cardiac Troponin I and T
      for the Diagnosis of Acute Myocardial Infarction: A Systematic Review.
AB  - BACKGROUND: The overall clinical decision limits of high-sensitivity cardiac
      troponin I (hs-cTnI; 26 ng/L) and T (hs-cTnT; 14 ng/L) may contribute to
      underdiagnosis of acute myocardial infarction in women. We performed a systematic
      review to investigate sex-specific and overall 99th percentiles of hs-cTnI and hs
      cTnT derived from healthy reference populations. CONTENT: We searched in PubMed
      and EMBASE for original studies, and by screening reference lists. Reference
      populations designed to establish 99th percentiles of hs-cTnI (Abbott) and/or hs
      cTnT (Roche), published between January 2009 and October 2017, were included. Sex
      specific and overall 99th percentile values of hs-cTnI and hs-cTnT were compared
      with overall clinical decision ranges (hs-cTnI, 23-30 ng/L; hs-cTnT, 13-25 ng/L).
      Twenty-eight studies were included in the systematic review. Of 16 hs-cTnI and 18
      hs-cTnT studies, 14 (87.5%) and 11 (61.1%) studies reported lower female-specific
      hs-cTn cutoffs than overall clinical decision ranges, respectively. Conversely,
      male-specific thresholds of both hs-cTnI and hs-cTnT were in line with currently
      used overall thresholds, particularly hs-cTnT (90% concordance). The variation of
      estimated overall 99th percentiles was much higher for hs-cTnI than hs-cTnT
      (29.4% vs 80.0% of hs-cTnI and hs-cTnT studies reported values within the current
      overall clinical decision range, respectively). SUMMARY: Our data show
      substantially lower female-specific upper reference limits of hs-cTnI and hs-cTnT
      than overall clinical decision limits of 26 ng/L and 14 ng/L, respectively. The
      statistical approach strongly affects the hs-cTnI threshold. Downward adjustment
      of hs-cTn thresholds in women may be warranted to reduce underdiagnosis of acute
      myocardial infarction in women.

PMID- 29844244
TI  - Intake of Different Dietary Proteins and Risk of Heart Failure in Men: The Kuopio
      Ischaemic Heart Disease Risk Factor Study.
AB  - BACKGROUND: Animal and plant protein intakes have indicated opposite associations
      with cardiovascular mortality risk. Whether dietary proteins are associated with
      risk of heart failure (HF) is unclear. Thus, we examined the associations of
      proteins from different food sources with risk of HF. METHODS AND RESULTS: The
      study included 2441 men aged 42 to 60 years at the baseline examinations in 1984
      to 1989 in the Kuopio Ischaemic Heart Disease Risk Factor Study. Protein intakes
      at baseline were assessed with 4-day dietary records. Data on incident HF cases
      were obtained from national registers. HF risk according to protein intake was
      estimated by Cox proportional hazard ratios. During the mean follow-up of 22.2
      years, 334 incident HF cases occurred. Higher intake of total protein indicated a
      trend toward increased risk of HF (multivariable-adjusted hazard ratio in the
      highest versus lowest quartile=1.33; 95% confidence interval: 0.95-1.85; P
      trend=0.05). The associations between specific types and sources of protein with
      incident HF were consistent with this overall finding although not all
      associations reached statistical significance. For example, the hazard ratio in
      the highest versus lowest quartile was 1.43 (95% confidence interval: 1.00-2.03;
      P-trend=0.07) for total animal protein and 1.17 (95% confidence interval: 0.72
      1.91; P-trend=0.35) for total plant protein. CONCLUSIONS: In middle-aged men,
      higher protein intake was marginally associated with increased risk of HF.
      CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique
      identifier: NCT03221127.

PMID- 29844246
TI  - External counterpulsation enhances neuroplasticity to promote stroke recovery.

PMID- 29844247
TI  - Erratum for Panayiotou et al., "Viperin Restricts Zika Virus and Tick-Borne
      Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation".

PMID- 29844248
TI  - Correction for Gaulke et al., "Intestinal Epithelial Barrier Disruption through
      Altered Mucosal MicroRNA Expression in Human Immunodeficiency Virus and Simian
      Immunodeficiency Virus Infections".

PMID- 29844249
TI  - Reanalysis of risks of childhood leukaemia with distance from overhead power
      lines in the UK.
AB  - Our previous study of childhood leukaemia and distance to high-voltage overhead
      power lines in the UK has been included in an international pooled analysis. That
      pooled analysis used different distance categories to those we did, which has
      focussed attention on the effect of that choice. We re-analyse our previous
      subjects, using finer distance categories. In the 1960s and 1970s, when we
      principally found an elevated risk, the risk did not fall monotonically with
      distance from the power line but had a maximum at 100-200 m. This weakens the
      evidence that any elevated risks are related to magnetic fields, and slightly
      strengthens the evidence for a possible effect involving residential mobility or
      other socioeconomic factors.

PMID- 29844250
TI  - Comparison of Flavonoids and Centella asiatica for the treatment of chronic anal
      fissure. A randomized clinical trial.
AB  - AIMS: We aim to test and compare the effects of Flavonoids (Fs) and Centella
      asiatica (Ca), and the traditional treatment to find out which best deals with
      healing time, bleeding and pain in the treatment of chronic Anal Fissure (AF).
      Materials of Study: 98 outpatients were divided randomly into treated (either Fs
      or Ca) and control group. The control group (Group C, n=32) received the
      traditional treatment along with the other two subgroups which were treated,
      additionally, with Fs (Group A, n=30) or Ca (Group B, n=36). Patients were
      observed once weekly over 8 consecutive weeks. RESULTS: The median time to stop
      bleeding in the group A was 1 week, in the Group B was 3 weeks and in the group C
      was 4 weeks. There were significant differences between Groups in terms of time
      to end bleeding (A vs B: p-value= 0.022; A vs C: p-value<0.001; B vs C: p
      value=0.070). As for pain score from baseline to the 2nd week were statistically
      different between Groups A and B on the one hand and Group C on the other hand (A
      vs C: p-value=0.004; B vs C: p-value 0.035). All patients healed within 8th week.
      DISCUSSION: Either patients treated with Fs or Ca experienced early pain
      disappearance. Fs and Ca did not show side effects CONCLUSIONS: The treatment
      with Fs is the most effective for bleeding. Patients additionally treated with
      either Fs or Ca experienced an earlier healing and disappearance of pain in
      comparison with patients underwent to the traditional treatment. KEY WORDS: Anal
      bleeding, Anal fissure, Defecation pain.

PMID- 29844251
TI  - Human Fibrinogen: Molecular and Genetic Aspects of Congenital Disorders.
AB  - Congenital fibrinogen disorders can be quantitative (afibrinogenemia,
      hypofibrinogenemia) or functional (dysfibrinognemia). To date, several genetic
      variants have been identified in individuals with fibrinogen disorders. The
      complexity of the fibrinogen molecules, formed by three non-identical chains and
      with a trinodal organization, renders the identification of molecular causes and
      of clinical and biochemical phenotypes very challenging. However, the
      acknowledgement of the type of molecular defect is crucial for a safer therapy,
      which is going to improve the clinical management of these patients. In this
      review, some aspects concerning molecular and clinical findings available on
      congenital fibrinogen disorders will be discussed.

PMID- 29844253
TI  - Influence of Homogenization on Microstructural Response and Mechanical Property
      of Al-Cu-Mn Alloy.
AB  - The evolution of the microstructures and properties of large direct chill (DC)
      cast Al-Cu-Mn alloy ingots during homogenization was investigated. The results
      revealed that the Al-Cu-Mn alloy ingots had severe microsegregation and the main
      secondary phase was Al2Cu, with minimal Al7Cu2Fe phase. Numerous primary eutectic
      phases existed in the grain boundary and the main elements were segregated at the
      interfaces along the interdendritic region. The grain boundaries became
      discontinuous, residual phases were effectively dissolved into the matrix, and
      the segregation degree of all elements was reduced dramatically during
      homogenization. In addition, the homogenized alloys exhibited improved
      microstructures with finer grain size, higher number density of dislocation
      networks, higher density of uniformly distributed theta' or theta phase (Al2Cu),
      and higher volume fraction of high-angle grain boundaries compared to the
      nonhomogenized samples. After the optimal homogenization scheme treated at 535 
      degrees C for 10 h, the tensile strength and elongation% were about 24 MPa, 20.5
      MPa, and 1.3% higher than those of the specimen without homogenization treatment.

PMID- 29844252
TI  - MAO-A Inhibitory Potential of Terpene Constituents from Ginger Rhizomes-A
      Bioactivity Guided Fractionation.
AB  - BACKGROUND: In the search for novel antidepressive drug candidates, bioguided
      fractionation of nonpolar constituents present in the oleoresin from ginger
      rhizomes (Zingiber officinale Roscoe, Zingiberaceae) was performed. This
      particular direction of the research was chosen due to the existing reports on
      the antidepressive properties of ginger total extract. The search for individual
      metabolites acting as MAO-A inhibitors, which correspond to the apparent effect
      of the total extract, is the subject of this work. METHODS: Hexane extracts from
      ginger rhizomes were fractionated by using column chromatography (including
      silica gel impregnated with silver nitrate) and semi-preparative high-performance
      chromatography. For the activity assessment, an in vitro monoamine oxidase A (MAO
      A) inhibition luminescence assay was performed on 10 purified terpenes: 1,8
      cineole, alpha-citronellal, geraniol, beta-sesquiphellandrene, gamma-terpinen,
      geranyl acetate, isobornyl acetate, terpinen-4-ol, (E,E)-alpha-farnesene, and
      alpha-zingiberene. RESULTS: Geraniol and (-)-terpinen-4-ol were found to be the
      strongest enzyme inhibitors with inhibition of 44.1% and 42.5%, respectively, at
      a concentration of 125 ug/mL. No differences in the inhibition potential were
      observed for the different groups of terpenes: sesquiterpenes, monoterpenes, or
      sesquiterpene alcohols; however, the two most active compounds contained a
      hydroxyl moiety. CONCLUSIONS: Terpene constituents from ginger's extract were
      found to exhibit moderate inhibitory properties against the MAO-A enzyme in in
      vitro tests.

PMID- 29844254
TI  - Milk Fermented by Specific Lactobacillus Strains Regulates the Serum Levels of IL
      6, TNF-alpha and IL-10 Cytokines in a LPS-Stimulated Murine Model.
AB  - Studies report that metabolites, such as peptides, present in fermented milk with
      specific lactic acid bacteria, may regulate cytokine production and exert an anti
      inflammatory effect. Hence, the cytokine regulatory effect of fermented milk by
      specific Lactobacillus strains was evaluated in a lipopolysaccharide (LPS)
      stimulated murine model. From twelve strains, three (J20, J23 and J28) were
      selected for their high proteolytic and acidifying capacities in milk and used
      for the in vivo study. Three treatments (fermented milk, FM; pasteurized
      fermented milk, PFM; and its 0.05) reduced pro-inflammatory cytokine (IL-6 and
      TNF-alpha) concentrations and significantly increased anti-inflammatory (IL-10)
      cytokine concentrations in comparison to the control; also, pro-inflammatory
      cytokines were reduced for animals treated with PFM10 (p < 0.05). RP-HPLC-MS/MS
      analysis showed that water-soluble extracts (.

PMID- 29844256
TI  - Effects of Build Orientation on Surface Morphology and Bone Cell Activity of
      Additively Manufactured Ti6Al4V Specimens.
AB  - Additive manufacturing of lightweight or functional structures by selective laser
      beam (SLM) or electron beam melting (EBM) is widespread, especially in the field
      of medical applications. SLM and EBM processes were applied to prepare Ti6Al4V
      test specimens with different surface orientations (0 degrees , 45 degrees  and
      90 degrees ). Roughness measurements of the surfaces were conducted and cell
      behavior on these surfaces was analyzed. Hence, human osteoblasts were seeded on
      test specimens to determine cell viability (metabolic activity, live-dead
      staining) and gene expression of collagen type 1 (Col1A1), matrix metalloprotease
      (MMP) 1 and its natural inhibitor, TIMP1, after 3 and 7 days. The surface
      orientation of specimens during the manufacturing process significantly
      influenced the roughness. Surface roughness showed significant impact on cellular
      viability, whereas differences between the time points day 3 and 7 were not
      found. Collagen type 1 mRNA synthesis rates in human osteoblasts were enhanced
      with increasing roughness. Both manufacturing techniques further influenced the
      induction of bone formation process in the cell culture. Moreover, the
      relationship between osteoblastic collagen type 1 mRNA synthesis rates and
      specimen orientation during the building process could be characterized by
      functional formulas. These findings are useful in the designing of biomedical
      applications and medical devices.

PMID- 29844258
TI  - Metabolomics in Radiation-Induced Biological Dosimetry: A Mini-Review and a
      Polyamine Study.
AB  - In this study, we elucidate that polyamine metabolite is a powerful biomarker to
      study post-radiation changes. Metabolomics in radiation biodosimetry, the
      application of a metabolomics analysis to the field of radiobiology, promises to
      increase the understanding of biological responses by ionizing radiation (IR).
      Radiation exposure triggers a complex network of molecular and cellular responses
      that impacts metabolic processes and alters the levels of metabolites. Such
      metabolites have potential as biomarkers for radiation dosimetry. Among
      metabolites, polyamine is one of many potential biomarkers to estimate radiation
      response. In addition, this review provides an opportunity for the understanding
      of a radiation metabolomics in biodosimetry and a polyamine case study.

PMID- 29844257
TI  - Tumor Size-Dependent Anticancer Efficacy of Chlorin Derivatives for Photodynamic
      Therapy.
AB  - Photodynamic therapy (PDT) with a suitable photosensitizer molecule is a
      promising anticancer treatment. We evaluated two chlorin molecules as potential
      photosensitizers, methyl pyropheophorbide a (MPPa) and N-methoxyl purpurinimide
      (NMPi), against A549 human lung adenocarcinoma cells in vitro as well as in A549
      tumor-bearing mice in vivo. Cell viability, microscopy, and fluorescence
      activated cell sorting (FACS) analyses were performed for the in vitro studies.
      MPPa and NMPi showed high phototoxicity in vitro, which was dependent on the
      concentration of the photosensitizers as well as the light irradiation time. In
      the animal study, tumor volume change, tumor surface alterations, and hematoxylin
      & eosin (H&E) and terminal deoxyribonucleotidyl transferse-mediated dUTP nick-end
      labelling (TUNEL) staining analyses were performed and compared between small
      (tumor volume of 50 mm3) size of initial tumors. MPPa and NMPi showed high
      anticancer efficacy against small-size tumors, indicating that early treatment
      with PDT is effective. Especially, repeated two times PDT with NMPi allowed
      almost complete eradication against small-size tumors. However, MPPa and NMPi
      were not effective against large-size tumors. In conclusion, the two chlorin
      derivatives, MPPa and NMPi, show good anticancer efficacy as promising
      photosensitizers for PDT in vitro and in vivo. Moreover, their activity in vivo
      was significantly dependent on the initial tumor size in mice, which confirms the
      importance of early cancer treatment.

PMID- 29844255
TI  - A Half-Century History of Applications of Antisense Oligonucleotides in Medicine,
      Agriculture and Forestry: We Should Continue the Journey.
AB  - Antisense oligonucleotides (ASO), short single-stranded polymers based on DNA or
      RNA chemistries and synthesized in vitro, regulate gene expression by binding in
      a sequence-specific manner to an RNA target. The functional activity and
      selectivity in the action of ASOs largely depends on the combination of
      nitrogenous bases in a target sequence. This simple and natural property of
      nucleic acids provides an attractive route by which scientists can create
      different ASO-based techniques. Over the last 50 years, planned and realized
      applications in the field of antisense and nucleic acid nanotechnologies have
      produced astonishing results and posed new challenges for further developments,
      exemplifying the essence of the post-genomic era. Today the majority of ASOs are
      chemically modified and/or incorporated within nanoparticles to enhance their
      stability and cellular uptake. This review critically analyzes some successful
      cases using the antisense approach in medicine to address severe diseases, such
      as Duchenne muscular dystrophy and spinal muscular atrophy, and suggests some
      prospective directions for future research. We also examine in detail the
      elaboration of unmodified insect-specific DNA insecticides and RNA preparations
      in the areas of agriculture and forestry, a relatively new branch of ASO that
      allows circumvention of the use of non-selective chemical insecticides. When
      considering the variety of successful ASO modifications with an efficient signal
      to-noise ratio of action, coupled with the affordability of in vitro
      oligonucleotide synthesis and post-synthesis procedures, we predict that the next
      half-century will produce a fruitful yield of tools created from effective ASO
      based end products.

PMID- 29844259
TI  - Real-World Use and Outcomes of ALK-Positive Crizotinib-Treated Metastatic NSCLC
      in US Community Oncology Practices: A Retrospective Observational Study.
AB  - INTRODUCTION: Around 3-5% of non-small cell lung cancers (NSCLC) are ALK
      positive. Crizotinib was the first approved ALK inhibitor from clinical trials.
      However, there are less data on the utilization and patient outcomes associated
      with crizotinib in real-world clinical practice. METHODS: This was a
      retrospective, observational study of adult crizotinib-treated ALK-positive
      metastatic NSCLC patients who received treatment between 1 September 2011 and 31
      October 2014, with follow up through 31 December 2015. Data were obtained via
      programmatic queries of the US Oncology Network/McKesson Specialty Health
      electronic health record database, supplemented with chart abstraction. Overall
      survival (OS) and time to treatment failure (TTF) were estimated from crizotinib
      initiation using the Kaplan-Meier (KM) method. RESULTS: Of the n = 199 ALK
      positive crizotinib-treated patients meeting eligibility criteria, crizotinib was
      prescribed as first line (1 L) in n = 123 (61.8%). The majority (88.9%) had
      confirmed adenocarcinoma histology and 32.2% had brain metastases at initial
      diagnosis. Median age at crizotinib initiation was 60.2 years (range 27.1-88.2);
      54.8% were never smokers, 33.7% were former smokers. Treatment of 250 mg, twice
      daily, was most commonly prescribed (89.5%) with the dose unchanged from an
      initial dose in 79.4% of patients. The primary discontinuation reason was
      progression (n = 91, 58.7%). Patients (3.2%) were identified as discontinuing
      crizotinib as a result of treatment-related toxicity. With median follow-up time
      of 13.0 months (min-max = 0.03-46.6), median OS from crizotinib initiation was
      33.8 months (95% CI = 24.3-38.8). Median TTF was 10.4 months. CONCLUSIONS:
      Crizotinib usage evaluated within the real-world setting is consistent with prior
      phase III clinical trial data, and illustrates the real-world effectiveness of
      crizotinib.

PMID- 29844260
TI  - Magnetic Detection Structure for Lab-on-Chip Applications Based on the Frequency
      Mixing Technique.
AB  - A magnetic frequency mixing technique with a set of miniaturized planar coils was
      investigated for use with a completely integrated Lab-on-Chip (LoC) pathogen
      sensing system. The system allows the detection and quantification of
      superparamagnetic beads. Additionally, in terms of magnetic nanoparticle
      characterization ability, the system can be used for immunoassays using the beads
      as markers. Analytical calculations and simulations for both excitation and pick
      up coils are presented; the goal was to investigate the miniaturization of simple
      and cost-effective planar spiral coils. Following these calculations, a Printed
      Circuit Board (PCB) prototype was designed, manufactured, and tested for limit of
      detection, linear response, and validation of theoretical concepts. Using the
      magnetic frequency mixing technique, a limit of detection of 15 ug/mL of 20 nm
      core-sized nanoparticles was achieved without any shielding.

PMID- 29844262
TI  - The Role of Diffusion-Weighted Magnetic Resonance Imaging in the Differentiation
      of Head and Neck Masses.
AB  - The purpose of this study was to evaluate the value of diffusion-weighted MRI (DW
      MRI) in differentiating benign and malignant head and neck masses by comparing
      their apparent diffusion coefficient (ADC) values. The study included 32 patients
      with a neck mass >1 cm in diameter who were examined with echo planar DW-MRI. Two
      different diffusion gradients (b values of b = 0 and b = 1000 s/mm2) were
      applied. DWI and ADC maps of 32 neck masses in 32 patients were obtained. Mean
      ADC values of benign and malignant neck lesions were measured and compared
      statistically. A total of 15 (46.9%) malignant masses and 17 (53.1%) benign
      masses were determined. Of all the neck masses, the ADC value of cystic masses
      was the highest and that of lymphomas was the lowest. The mean ADC values of
      benign and malignant neck masses were 1.57 * 10-3 mm2/s and 0.90 * 10-3 mm2/s,
      respectively. The difference between mean ADC values of benign and malignant neck
      masses was significant (p < 0.01). Diffusion-weighted MRI with ADC measurements
      can be useful in the differential diagnosis of neck masses.

PMID- 29844261
TI  - Antioxidant Activity and Spectroscopic Characteristics of Extractable and Non
      Extractable Phenolics from Terminalia sericea Burch. ex DC.
AB  - The aim of this study was to determine the antioxidant activity of the
      extractable and non-extractable phenolics of Terminalia. Sericea Burch. Ex DC.
      Free, ester bound, ether or glycoside bound and insoluble phenolics were
      extracted from the fruit, leaves, stem, and root samples. Follin Ciocalteu was
      used to estimate the phenolic content while DPPH (2,2-diphenyl-1-picrylhydrazyl)
      assay was used to determine the antioxidant activity. The data obtained were
      subjected to multivariate analysis for relationships. The result indicated that
      the highest average total phenolic contents and antioxidant activities were found
      in the free (14.8 mgGAE/g; IC50 6.8 MUg/mL) and ester bound (15.1 mgGAE/g; IC50
      6.4 MUg/mL) extractable phenolics. There was a strong negative correlation
      between TPC and DPPH (r = -0.828). Agglomerative hierarchical clustering revealed
      three clusters. Cluster one contained the insoluble and glycoside phenolics while
      cluster 2 contained only free phenolic acid of the root. The third cluster was
      predominantly free and ester bound phenolic extracts. The principal component
      analysis score plot indicated two major clusters with factor 1 (F1) explaining
      61% of the variation. The nuclear magnetic resonance spectroscopy spectra
      indicated that gallic acid and resveratrol are the major phenolic compounds
      present in the root. This study has demonstrated that extractable phenolics
      contributed more to the antioxidant activities compared to the non-extractables.

PMID- 29844263
TI  - Exploring the Dual Inhibitory Activity of Novel Anthranilic Acid Derivatives
      towards alpha-Glucosidase and Glycogen Phosphorylase Antidiabetic Targets:
      Design, In Vitro Enzyme Assay, and Docking Studies.
AB  - A few new anthranilate diamide derivatives, 3a-e, 5a-c and 7a-d, were designed,
      synthesized, and evaluated for their inhibitory activity against two interesting
      antidiabetic targets, alpha-glucosidase and glycogen phosphorylase enzymes.
      Different instrumental analytical tools were applied in identification and
      conformation of their structures like; 13C NMR, 1H NMR and elemental analysis.
      The screening of the novel compounds showed potent inhibitory activity with
      nanomolar concentration values. The most active compounds (5c) and (7b) showed
      the highest inhibitory activity against alpha-glucosidase and glycogen
      phosphorylase enzymes IC50 = 0.01247 +/- 0.01 uM and IC50 = 0.01372 +/- 0.03 uM,
      respectively. In addition, in vivo testing of the highly potent alpha-glucosidase
      inhibitor (7b) on rats with DTZ-induced diabetes was done and showed significant
      reduction of blood glucose levels compared to the reference drug. Furthermore, a
      molecular docking study was performed to help understand the binding interactions
      of the most active analogs with these two enzymes. The data obtained from the
      molecular modeling were correlated with those obtained from the biological
      screening. These data showed considerable antidiabetic activity for these newly
      synthesized compounds.

PMID- 29844264
TI  - Genome-Wide Screening and Characterization of the Dof Gene Family in Physic Nut
      (Jatropha curcas L.).
AB  - Physic nut (Jatropha curcas L.) is a species of flowering plant with great
      potential for biofuel production and as an emerging model organism for functional
      genomic analysis, particularly in the Euphorbiaceae family. DNA binding with one
      finger (Dof) transcription factors play critical roles in numerous biological
      processes in plants. Nevertheless, the knowledge about members, and the
      evolutionary and functional characteristics of the Dof gene family in physic nut
      is insufficient. Therefore, we performed a genome-wide screening and
      characterization of the Dof gene family within the physic nut draft genome. In
      total, 24 JcDof genes (encoding 33 JcDof proteins) were identified. All the JcDof
      genes were divided into three major groups based on phylogenetic inference, which
      was further validated by the subsequent gene structure and motif analysis. Genome
      comparison revealed that segmental duplication may have played crucial roles in
      the expansion of the JcDof gene family, and gene expansion was mainly subjected
      to positive selection. The expression profile demonstrated the broad involvement
      of JcDof genes in response to various abiotic stresses, hormonal treatments and
      functional divergence. This study provides valuable information for better
      understanding the evolution of JcDof genes, and lays a foundation for future
      functional exploration of JcDof genes.

PMID- 29844265
TI  - Probiotic Lactobacillus Paracasei Expressing a Nucleic Acid-Hydrolyzing Minibody
      (3D8 Scfv) Enhances Probiotic Activities in Mice Intestine as Revealed by
      Metagenomic Analyses.
AB  - Probiotics are well known for their beneficial effects for animals, including
      humans and livestock. Here, we tested the probiotic activity of Lactobacillus
      paracasei expressing 3D8 scFv, a nucleic acid-hydrolyzing mini-antibody, in mice
      intestine. A total of 18 fecal samples derived from three different conditions at
      two different time points were subjected to high-throughput 16S ribosomal RNA
      (rRNA) metagenomic analyses. Bioinformatic analyses identified an average of 290
      operational taxonomic units. After administration of L. paracasei, populations of
      the probiotics L. paracasei, Lactobacillus reuteri, and Pediococcus acidilactici
      increased, whereas the population of harmful bacteria such as Helicobacter
      species decreased. Furthermore, continuous administration of L. paracasei
      resulted in L. paracasei emerging as the dominant probiotic after competition
      with other existing probiotics. Expression of 3D8 scFv protein specifically
      increased the population of P. acidilactici, which is another probiotic. In
      summary, our results showed that L. paracasei expressing 3D8 scFv protein
      enhanced probiotic activity in mice intestine with no observable side effects.
      Thus, the system developed in this study may be a good tool for the expression of
      recombinant protein using probiotics.

PMID- 29844266
TI  - Separation and Quantification of Four Main Chiral Glucosinolates in Radix
      Isatidis and Its Granules Using High-Performance Liquid Chromatography/Diode
      Array Detector Coupled with Circular Dichroism Detection.
AB  - As chemical drugs, separation and quantification of the specific enantiomer from
      the chiral compounds in herbal medicines are becoming more important. To clarify
      the chemical characterization of chiral glucosinolates-the antiviral active
      ingredients of Radix Isatidis, an optimized efficient method of HPLC-UV-CD was
      developed to simultaneously separate and quantify the four main chiral
      glucosinolates: progoitrin, epiprogoitrin, and R,S-goitrin. The first step was to
      determine progoitrin, epiprogoitrin, and R,S-goitrin using HPLC-UV, and then
      determine the R-goitrin and S-goitrin by coupling with CD detection.
      Subsequently, through the linear relations between anisotropy factor (g factor)
      and the percent optical purity of R-goitrin, the contents of R-goitrin and S
      goitrin from the R,S-goitrin mixture were calculated separately. Furthermore, the
      chemical composition features of the four chiral glucosinolates in 37 samples
      from crude drugs, decoction pieces, and granules of R. Isatidis were conducted.
      The total content of the four glucosinolates was obviously higher in crude drugs,
      and the variance character of each glucosinolate contents was different. In
      summary, the accurate measurement method reported here allows for better control
      of the internal quality of R. Isatidis and its granules and provides a powerful
      approach for the analysis of other chiral components in traditional Chinese
      medicines.

PMID- 29844267
TI  - Effects of a Chimeric Lysin against Planktonic and Sessile Enterococcus faecalis
      Hint at Potential Application in Endodontic Therapy.
AB  - Enterococcus faecalis is a commensal opportunistic pathogen found in the
      intestine, mouth, and vaginal tract of humans. As an invasive pathogen in the
      oral cavity, E. faecalis is one of the leading causes of periapical endodontic
      lesions. However, due to the strong biofilm-forming capacity and tolerance of E.
      faecalis to conventional antibiotics and treatments, limited therapeutic options
      are available. In the present study, we investigated the activity of ClyR, a
      chimeric lysin with extended streptococcal lytic spectrum, against planktonic and
      sessile E. faecalis cells in vitro and in an ex vivo dental model. Our results
      showed that ClyR has robust and rapid lytic activity against multiple E. faecalis
      strains, killing >90% planktonic cells within 1 min at a concentration of 50
      MUg/mL. The biochemical experiments combined with microscopy analysis revealed
      that ClyR degrades E. faecalis biofilm with high efficacy in a dose-dependent
      manner, reducing the survival rate to 90% viable bacteria within biofilms at a
      low dose of 50 MUg/mL, which is much better than ampicillin and similar to
      calcium hydroxide, the extensively used routine intracanal medicament in the
      treatment of endodontics and dental traumatology. The robust activity of ClyR
      against both planktonic and sessile E. faecalis suggests the potential of ClyR in
      treating endodontic infections caused by E. faecalis.

PMID- 29844268
TI  - Synthesis of 2-Deoxybrassinosteroids Analogs with 24-nor, 22(S)-23-Dihydroxy-Type
      Side Chains from Hyodeoxycholic Acid.
AB  - Natural brassinosteroids are widespread in the plant kingdom and it is known that
      they play an important role in regulating plant growth. In this study, two new
      brassinosteroid analogs with shorter side chains but keeping the diol function
      were synthesized. Thus, the synthesis of 2-deoxybrassinosteroids analogs of the
      3alpha-hydroxy-24-nor, 22,23-dihydroxy-5alpha-cholestane side chain type is
      described. The starting material is a derivative from hyodeoxycholic acid (4),
      which was obtained with an overall yield of 59% following a previously reported
      five step route. The side chain of this intermediate was modified by oxidative
      decarboxylation to get a terminal olefin at the C22-C23 position (compound 20)
      and subsequent dihydroxylation of the olefin. The resulting epimeric mixture of
      21a, 21b was separated and the absolute configuration at the C22 carbon for the
      main product 21a was elucidated by single crystal X-ray diffraction analysis of
      the benzoylated derivative 22. Finally, lactonization of 21a through a Baeyer
      Villiger oxidation of triacetylated derivative 23, using CF3CO3H/CHCl3 as oxidant
      system, leads to lactones 24 and 25 in 35% and 14% yields, respectively.
      Deacetylation of these compounds leads to 2-deoxybrassinosteroids 18 and 19 in
      86% and 81% yields. Full structural characterization of all synthesized compounds
      was achieved using their 1D, 2D NMR, and HRMS data.

PMID- 29844269
TI  - Effects of Periostracum Cicadae on Cytokines and Apoptosis Regulatory Proteins in
      an IgA Nephropathy Rat Model.
AB  - Periostracum cicadae, the cast-off shell of the cicada Cryptotympana pustulata
      Fabricius, is used in traditional Chinese medicine for its diaphoretic,
      anticonvulsive, sedative, antipyretic, and antiallergic effects. However, the
      exact pathogenesis of immunoglobulin A nephropathy (IgAN) remains unclear,
      thereby hindering investigations to identify novel therapeutic agents. A rat IgAN
      model was established by administration of bovine serum albumin,
      lipopolysaccharide, and carbon tetrachloride, which simultaneously established
      blood stasis and a heat syndrome model. The animals were sacrificed to detect
      changes in protein levels in urine and blood. Immunofluorescence was performed to
      assess IgA deposition in the glomeruli. Tumor necrosis factor-alpha (TNF-alpha),
      interleukin-1beta (IL-1beta), and interleukin 6 (IL-6) levels were measured in
      bronchoalveolar lavage fluid (BALF) by enzyme-linked immunosorbent assay.
      Hematology and eosin, periodic acid-Schiff, TUNEL (TdT-mediated dUTP Nick-End
      Labeling), and immunohistochemical staining were performed to evaluate
      histopathological changes in kidney tissues. Additionally, target-related
      proteins were measured by Western blotting. Periostracum cicadae resulted in a
      reduction in blood and urine protein levels. Serum TNF-alpha, IL-1beta, and IL-6
      levels significantly decreased in the periostracum cicadae-treated groups
      compared to the IgAN group. Furthermore, a reduction in MCP-1 (Monocyte
      Chemotactic Protein-1), TLR4 ((Toll-Like Receptor 4)), and IgA expression levels
      and a dose-dependent increase in caspase 3 expression were observed in response
      to periostracum cicadae treatment. TGF-beta1(Transforming Growth Factor-beta)
      levels decreased, whereas that of Fas increased in the kidney tissues of the
      periostracum cicadae-treated groups. The findings of the present study indicate
      that periostracum cicadae induces apoptosis and improves kidney inflammation and
      fibrosis in IgA nephropathy rat models.

PMID- 29844271
TI  - Initial Self-Healing Temperatures of Asphalt Mastics Based on Flow Behavior
      Index.
AB  - Increasing temperature is a simple and convenient method to accelerate the self
      healing process of bitumen. However, bitumen may not achieve the healing
      capability at lower temperature, and may be aged if temperature is too high. In
      addition, the bitumen is mixed with mineral filler and formed as asphalt mastic
      in asphalt concrete, so it is more accurate to study the initial self-healing
      from the perspective of asphalt mastic. The primary purpose of this research was
      to examine the initial self-healing temperature of asphalt mastic, which was
      determined by the flow behavior index obtained from the flow characteristics.
      Firstly, the texture and geometry characteristics of two fillers were analyzed,
      and then the initial self-healing temperature of nine types of asphalt mastic,
      pure bitumen (PB) and styrene-butadiene-styrene (SBS) modified bitumen were
      determined by the flow behavior index. Results demonstrate that the average
      standard deviation of gray-scale texture value of limestone filler (LF) is 21.24%
      lower than that of steel slag filler (SSF), showing that the steel slag filler
      has a better particle distribution and geometry characteristics. Also the initial
      self-healing temperatures of asphalt mastics with 0.2, 0.4 and 0.6 LF-PB volume
      ratio are 46.5  degrees C, 47.2  degrees C and 49.4  degrees C, which are 1.4 
      degrees C, 0.8  degrees C and 0.4  degrees C higher than that of asphalt mastics
      with SSF-PB, but not suitable for the evaluation of asphalt mastic contained SBS
      modified bitumen because of unique structure and performance of SBS.

PMID- 29844270
TI  - Comparison of the Microtensile Bond Strength of a Polyetherketoneketone (PEKK)
      Tooth Post Cemented with Various Surface Treatments and Various Resin Cements.
AB  - The aim of this in-vitro research was to evaluate the microtensile bond strength
      in the newly introduced PEKK tooth post with various surface treatments and resin
      cements. A fiberglass tooth post was included in order to compare it with PEKK as
      a possible post material. The microtensile bond strengths of the fiberglass post
      (FRC Postec Plus) and the PEKK post (Pekkton(r)) were tested using three kinds of
      self-adhesive resin cements (G-CEM LinkAce, Multilink Speed, and RelyX U200) and
      one self-etching resin cement (PANAVIA F2.0). The surface treatments of the
      fiberglass posts were processed according to the manufacturer's recommendations
      (F1, application of 37% phosphoric acid etching gel and silanization). For the
      PEKK post groups, various surface treatments were performed like no surface
      treatment (P1), sandblasting (P2), silica-coating and silanization (P3), and
      sandblasting with a composite primer (P4). In the surface treatment, PEKK posts
      with silica coating and silane treatment (P3) showed a significantly higher
      microtensile bond strength (mean MPa: 18.09, p < 0.05). The highest microtensile
      bond strength was shown when the PEKK posts were treated with a silica coating
      and silane treatment and cemented with RelyX U200 (mean MPa: 22.22). The PEKK
      posts with surface treatments of silica-coating and silanization or sandblasting
      displayed superior microtensile bond strengths (mean MPa: 18.09 and 16.25,
      respectively) compared to the conventional fiberglass posts (mean MPa: 14.93, p <
      0.05).

PMID- 29844273
TI  - Mosses Are Better than Leaves of Vascular Plants in Monitoring Atmospheric Heavy
      Metal Pollution in Urban Areas.
AB  - Mosses and leaves of vascular plants have been used as bioindicators of
      environmental contamination by heavy metals originating from various sources.
      This study aims to compare the metal accumulation capabilities of mosses and
      vascular species in urban areas and quantify the suitability of different taxa
      for monitoring airborne heavy metals. One pleurocarpous feather moss species,
      Haplocladium angustifolium, and two evergreen tree species, Cinnamomum
      bodinieriOsmanthus fragrans, and substrate soil were sampled in the urban area of
      different land use types in Wuhan City in China. The concentrations of Ag, As,
      Cd, Co, Cr, Cu, Mn, Mo, Ni, V, Pb, and Zn in these samples were analyzed by
      inductively coupled plasma mass spectrometry. The differences of heavy metals
      concentration in the three species showed that the moss species was considerably
      more capable of accumulating heavy metals than tree leaves (3 times to 51 times).
      The accumulated concentration of heavy metals in the moss species depended on the
      metal species and land use type. The enrichment factors of metals for plants and
      the correlations of metals in plants with corresponding metals in soil reflected
      that the accumulated metals in plants stemmed mostly from atmospheric deposition,
      rather than the substrate soil. Anthropogenic factors, such as traffic emissions
      from automobile transportation and manufacturing industries, were primarily
      responsible for the variations in metal pollutants in the atmosphere and
      subsequently influenced the metal accumulation in the mosses. This study
      elucidated that the moss species H. angustifolium is relatively more suitable
      than tree leaves of C. bodinieri and O. fragrans in monitoring heavy metal
      pollution in urban areas, and currently Wuhan is at a lower contamination level
      of atmospheric heavy metals than some other cities in China.

PMID- 29844274
TI  - Review of Fabrication Methods, Physical Properties, and Applications of
      Nanostructured Copper Oxides Formed via Electrochemical Oxidation.
AB  - Typically, anodic oxidation of metals results in the formation of hexagonally
      arranged nanoporous or nanotubular oxide, with a specific oxidation state of the
      transition metal. Recently, the majority of transition metals have been anodized;
      however, the formation of copper oxides by electrochemical oxidation is yet
      unexplored and offers numerous, unique properties and applications. Nanowires
      formed by copper electrochemical oxidation are crystalline and composed of
      cuprous (CuO) or cupric oxide (Cu2O), bringing varied physical and chemical
      properties to the nanostructured morphology and different band gaps: 1.44 and
      2.22 eV, respectively. According to its Pourbaix (potential-pH) diagram, the
      passivity of copper occurs at ambient and alkaline pH. In order to grow oxide
      nanostructures on copper, alkaline electrolytes like NaOH and KOH are used. To
      date, no systemic study has yet been reported on the influence of the operating
      conditions, such as the type of electrolyte, its temperature, and applied
      potential, on the morphology of the grown nanostructures. However, the numerous
      reports gathered in this paper will provide a certain view on the matter. After
      passivation, the formed nanostructures can be also post-treated. Post-treatments
      employ calcinations or chemical reactions, including the chemical reduction of
      the grown oxides. Nanostructures made of CuO or Cu2O have a broad range of
      potential applications. On one hand, with the use of surface morphology, the
      wetting contact angle is tuned. On the other hand, the chemical composition (pure
      Cu2O) and high surface area make such materials attractive for renewable energy
      harvesting, including water splitting. While compared to other fabrication
      techniques, self-organized anodization is a facile, easy to scale-up, time
      efficient approach, providing high-aspect ratio one-dimensional (1D)
      nanostructures. Despite these advantages, there are still numerous challenges
      that have to be faced, including the strict control of the chemical composition
      and morphology of the grown nanostructures, their uniformity, and understanding
      the mechanism of their growth.

PMID- 29844272
TI  - The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function.
AB  - Chronic kidney disease (CKD) is associated with profound vascular remodeling,
      which accelerates the progression of cardiovascular disease. This remodeling is
      characterized by intimal hyperplasia, accelerated atherosclerosis, excessive
      vascular calcification, and vascular stiffness. Vascular smooth muscle cell
      (VSMC) dysfunction has a key role in the remodeling process. Under uremic
      conditions, VSMCs can switch from a contractile phenotype to a synthetic
      phenotype, and undergo abnormal proliferation, migration, senescence, apoptosis,
      and calcification. A growing body of data from experiments in vitro and animal
      models suggests that uremic toxins (such as inorganic phosphate, indoxyl sulfate
      and advanced-glycation end products) may directly impact the VSMCs' physiological
      functions. Chronic, low-grade inflammation and oxidative stress-hallmarks of CKD
      are also strong inducers of VSMC dysfunction. Here, we review current knowledge
      about the impact of uremic toxins on VSMC function in CKD, and the consequences
      for pathological vascular remodeling.

PMID- 29844276
TI  - A Friction-Inertial-Based Rotary Motor: Design, Modelling and Experiments.
AB  - A friction-inertial-based rotary motor driven by shear piezoelectric actuators
      (SPAs) is proposed in this paper, which possesses many superior features,
      including high resolution, compact size, large load-capacity, and low cost. In
      order to eliminate the step loss and increase the step size when an external load
      is applied, the power-function-shape driving signal was used to actuate the
      rotary motor. According to the step characteristics under this driving signal,
      two motion modes were observed and defined, namely the stick-shoot motion mode
      and the stick-slip-shoot motion mode. The former motion mode can realize a large
      step size while the later one cannot due to the slipping during the rising phase.
      After analyzing the results from the numerical simulation and the experiment
      study, it was found that the motion performance of the motor is closely related
      to the preload and the base number of the driving signal rather than the size of
      SPAs, which means the motor can be further downsized according to its actual
      requirements.

PMID- 29844275
TI  - Stand-Alone Wearable System for Ubiquitous Real-Time Monitoring of Muscle
      Activation Potentials.
AB  - Wearable technology is attracting most attention in healthcare for the
      acquisition of physiological signals. We propose a stand-alone wearable surface
      ElectroMyoGraphy (sEMG) system for monitoring the muscle activity in real time.
      With respect to other wearable sEMG devices, the proposed system includes
      circuits for detecting the muscle activation potentials and it embeds the
      complete real-time data processing, without using any external device. The system
      is optimized with respect to power consumption, with a measured battery life that
      allows for monitoring the activity during the day. Thanks to its compactness and
      energy autonomy, it can be used outdoor and it provides a pathway to valuable
      diagnostic data sets for patients during their own day-life. Our system has
      performances that are comparable to state-of-art wired equipment in the detection
      of muscle contractions with the advantage of being wearable, compact, and
      ubiquitous.

PMID- 29844278
TI  - Adaptive Obstacle Detection for Mobile Robots in Urban Environments Using
      Downward-Looking 2D LiDAR.
AB  - Environment perception is important for collision-free motion planning of outdoor
      mobile robots. This paper presents an adaptive obstacle detection method for
      outdoor mobile robots using a single downward-looking LiDAR sensor. The method
      begins by extracting line segments from the raw sensor data, and then estimates
      the height and the vector of the scanned road surface at each moment.
      Subsequently, the segments are divided into either road ground or obstacles based
      on the average height of each line segment and the deviation between the line
      segment and the road vector estimated from the previous measurements. A series of
      experiments have been conducted in several scenarios, including normal scenes and
      complex scenes. The experimental results show that the proposed approach can
      accurately detect obstacles on roads and could effectively deal with the
      different heights of obstacles in urban road environments.

PMID- 29844277
TI  - Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections.
AB  - The CRISPR/Cas9 system has been applied in the genome editing and disruption of
      latent infections for herpesviruses such as the herpes simplex virus, Epstein
      Barr virus, cytomegalovirus, and Kaposi's sarcoma-associated herpesvirus.
      CRISPR/Cas9-directed mutagenesis can introduce similar types of mutations to the
      viral genome as can bacterial artificial chromosome recombination engineering,
      which maintains and reconstitutes the viral genome successfully. The cleavage
      mediated by CRISPR/Cas9 enables the manipulation of disease-associated viral
      strains with unprecedented efficiency and precision. Additionally, current
      therapies for herpesvirus productive and latent infections are limited in
      efficacy and cannot eradicate viruses. CRISPR/Cas9 is potentially adapted for
      antiviral treatment by specifically targeting viral genomes during latent
      infections. This review, which focuses on recently published progress, suggests
      that the CRISPR/Cas9 system is not only a useful tool for basic virology
      research, but also a promising strategy for the control and prevention of
      herpesvirus latent infections.

PMID- 29844280
TI  - A Study of the Particle-Level Fabric and Morphology of Granular Soils under One
      Dimensional Compression Using Insitu X-ray CT Imaging.
AB  - The particle morphology and fabric of a granular soil influence its mechanical
      behavior. This study focuses on the evolution of the particle-level fabric and
      morphology of a uniformly graded sand sample subjected to one-dimensional
      compression up to 64 MPa. The microstructural changes with increased stresses
      were captured using in situ high-resolution X-ray computed tomography (X-ray CT)
      imaging. The processed images of particles were separated using the Monash
      Particle Separation Method (MPSM) for subsequent fabric and morphological
      analyses. The variations of various fabric parameters were studied using the
      separated particle volumes. New methods of assessing the morphology and
      crushability of particles were introduced including a comprehensive algorithm for
      determining coordination number, branch and contact normal vectors. Results of
      all fabric parameters were analyzed and discussed with reference to observed
      changes. Potential mechanisms were identified and relevant correlations were
      developed where warranted.

PMID- 29844279
TI  - UDP-Glucose 4-Epimerase and beta-1,4-Galactosyltransferase from the Oyster
      Magallana gigas as Valuable Biocatalysts for the Production of Galactosylated
      Products.
AB  - Uridine diphosphate galactose (UDP-galactose) is a valuable building block in the
      enzymatic synthesis of galactose-containing glycoconjugates. UDP-glucose 4
      epimerase (UGE) is an enzyme which catalyzes the reversible conversion of
      abundantly available UDP-glucose to UDP-galactose. Herein, we described the
      cloning, expression, purification, and biochemical characterization of an
      unstudied UGE from the oyster Magallana gigas (MgUGE). Activity tests of
      recombinantly expressed MgUGE, using HPLC (high-performance liquid
      chromatography), mass spectrometry, and photometric assays, showed an optimal
      temperature of 16  degrees C, and reasonable thermal stability up to 37  degrees
      C. No metal ions were required for enzymatic activity. The simple nickel-affinity
      purification procedure makes MgUGE a valuable biocatalyst for the synthesis of
      UDP-galactose from UDP-glucose. The biosynthetic potential of MgUGE was further
      exemplified in a coupled enzymatic reaction with an oyster-derived beta-1,4
      galactosyltransferase (MgGalT7), allowing the galactosylation of the model
      substrate para-nitrophenol xylose (pNP-xylose) using UDP-glucose as the starting
      material.

PMID- 29844281
TI  - Small Universal Bacteria and Plasmid Computing Systems.
AB  - Bacterial computing is a known candidate in natural computing, the aim being to
      construct "bacterial computers" for solving complex problems. In this paper, a
      new kind of bacterial computing system, named the bacteria and plasmid computing
      system (BP system), is proposed. We investigate the computational power of BP
      systems with finite numbers of bacteria and plasmids. Specifically, it is
      obtained in a constructive way that a BP system with 2 bacteria and 34 plasmids
      is Turing universal. The results provide a theoretical cornerstone to construct
      powerful bacterial computers and demonstrate a concept of paradigms using a
      "reasonable" number of bacteria and plasmids for such devices.

PMID- 29844282
TI  - In Vitro Antifungal Activity of New and Known Geranylated Phenols against
      Phytophthora cinnamomi Rands.
AB  - A series of new and known geranylated phenol/methoxyphenol derivatives has been
      tested in vitro as inhibitor agents of mycelial growth of Phytophthora cinnamomi.
      The activity of tested compounds is correlated with the nature, number, and
      position of the substituent group on the aromatic ring. Results indicate that the
      most active geranylated derivatives are those having two hydroxyl groups (or one 
      OH and one -OCH3) attached to the aromatic ring. Interestingly, these derivatives
      are as active as Metalaxil(r), a commonly used commercial fungicide. Thus, our
      results suggest that some of these compounds might be of agricultural interest
      due to their potential use as fungicides against P. cinnamomi. The effect of
      structure on fungicide activity is discussed in terms of electronic distribution
      on both the aromatic ring and side geranyl chain. All tested compounds have been
      synthesized by direct coupling of geraniol and the respective phenol.
      Interestingly, new digeranylated derivatives were obtained by increasing the
      reaction time.

PMID- 29844285
TI  - Caching Joint Shortcut Routing to Improve Quality of Service for Information
      Centric Networking.
AB  - Hundreds of thousands of ubiquitous sensing (US) devices have provided an
      enormous number of data for Information-Centric Networking (ICN), which is an
      emerging network architecture that has the potential to solve a great variety of
      issues faced by the traditional network. A Caching Joint Shortcut Routing (CJSR)
      scheme is proposed in this paper to improve the Quality of service (QoS) for ICN.
      The CJSR scheme mainly has two innovations which are different from other in
      network caching schemes: (1) Two routing shortcuts are set up to reduce the
      length of routing paths. Because of some inconvenient transmission processes, the
      routing paths of previous schemes are prolonged, and users can only request data
      from Data Centers (DCs) until the data have been uploaded from Data Producers
      (DPs) to DCs. Hence, the first kind of shortcut is built from DPs to users
      directly. This shortcut could release the burden of whole network and reduce
      delay. Moreover, in the second shortcut routing method, a Content Router (CR)
      which could yield shorter length of uploading routing path from DPs to DCs is
      chosen, and then data packets are uploaded through this chosen CR. In this
      method, the uploading path shares some segments with the pre-caching path, thus
      the overall length of routing paths is reduced. (2) The second innovation of the
      CJSR scheme is that a cooperative pre-caching mechanism is proposed so that QoS
      could have a further increase. Besides being used in downloading routing, the pre
      caching mechanism can also be used when data packets are uploaded towards DCs.
      Combining uploading and downloading pre-caching, the cooperative pre-caching
      mechanism exhibits high performance in different situations. Furthermore, to
      address the scarcity of storage size, an algorithm that could make use of storage
      from idle CRs is proposed. After comparing the proposed scheme with five existing
      schemes via simulations, experiments results reveal that the CJSR scheme could
      reduce the total number of processed interest packets by 54.8%, enhance the cache
      hits of each CR and reduce the number of total hop counts by 51.6% and cut down
      the length of routing path for users to obtain their interested data by 28.6
      85.7% compared with the traditional NDN scheme. Moreover, the length of uploading
      routing path could be decreased by 8.3-33.3%.

PMID- 29844283
TI  - Biological and Psychosocial Processes in the Development of Children's Appetitive
      Traits: Insights from Developmental Theory and Research.
AB  - There has been increasing concern expressed about children's food intakes and
      dietary patterns. These are closely linked to children's appetitive traits (such
      as disinhibited eating and food fussiness/neophobia). Research has examined both
      biological and psychosocial correlates or predictors of these traits. There has
      been less focus on possible processes or mechanisms associated with children's
      development of these traits and research that links biological and psychosocial
      factors. There is an absence of research that links biological and psychosocial
      factors. In the present article, we outline a model intended to facilitate theory
      and research on the development of appetitive traits. It is based on scholarship
      from developmental theory and research and incorporates biological factors such
      as genetic predispositions and temperament as well as psychosocial factors in
      terms of parent cognitions, feeding styles and feeding practices. Particular
      attention is directed to aspects such as emotional eating and feeding, self
      regulation of energy intake, and non-shared family environments. We highlight the
      opportunity for longitudinal research that examines bidirectional, transactional
      and cascade processes and uses a developmental framework. The model provides a
      basis for connecting the biological foundations of appetitive traits to system
      level analysis in the family. Knowledge generated through the application of the
      model should lead to more effective prevention and intervention initiatives.

PMID- 29844284
TI  - Review of Intraocular Pharmacokinetics of Anti-Infectives Commonly Used in the
      Treatment of Infectious Endophthalmitis.
AB  - Although intravitreal administration of anti-infectives represents the standard
      treatment for infectious endophthalmitis, the knowledge about their
      pharmacokinetics is still limited. In this review, we aimed to summarise the
      factors influencing the pharmacokinetics of the anti-infective agents. We have
      conducted a comprehensive review of the preclinical pharmacokinetic parameters
      obtained in different studies of intravitreal injections of anti-infectives
      performed on animals, mainly rabbits. The two aspects with the biggest influence
      on pharmacokinetics are the distribution in the vitreous humour and the
      elimination through the posterior segment. The distribution can be affected by
      the molecular weight of the drug, the convection flow of the vitreous, the
      condition of the vitreous humour depending on the age of the patient, the
      possible interactions between the drug and the components of the vitreous, and
      the presence of vitrectomy. Meanwhile, the elimination includes the metabolism of
      the drug, the clearance via the anterior and posterior routes, and the possible
      inflammation of the eye resulting from the disease. Understanding the
      pharmacokinetics of the anti-infectives used in clinical practice is essential
      for a correct application. The information provided in this review could offer
      guidance for selecting the best therapeutic option according to the
      characteristics of the drugs.

PMID- 29844286
TI  - Phycotoxins in Marine Shellfish: Origin, Occurrence and Effects on Humans.
AB  - Massive phytoplankton proliferation, and the consequent release of toxic
      metabolites, can be responsible for seafood poisoning outbreaks: filter-feeding
      mollusks, such as shellfish, mussels, oysters or clams, can accumulate these
      toxins throughout the food chain and present a threat for consumers' health.
      Particular environmental and climatic conditions favor this natural phenomenon,
      called harmful algal blooms (HABs); the phytoplankton species mostly involved in
      these toxic events are dinoflagellates or diatoms belonging to the genera
      Alexandrium, Gymnodinium, Dinophysis, and Pseudo-nitzschia. Substantial economic
      losses ensue after HABs occurrence: the sectors mainly affected include
      commercial fisheries, tourism, recreational activities, and public health
      monitoring and management. A wide range of symptoms, from digestive to nervous,
      are associated to human intoxication by biotoxins, characterizing different and
      specific syndromes, called paralytic shellfish poisoning, amnesic shellfish
      poisoning, diarrhetic shellfish poisoning, and neurotoxic shellfish poisoning.
      This review provides a complete and updated survey of phycotoxins usually found
      in marine invertebrate organisms and their relevant properties, gathering
      information about the origin, the species where they were found, as well as their
      mechanism of action and main effects on humans.

PMID- 29844287
TI  - Phage-Derived Peptidoglycan Degrading Enzymes: Challenges and Future Prospects
      for In Vivo Therapy.
AB  - Peptidoglycan degrading enzymes are of increasing interest as antibacterial
      agents, especially against multi-drug resistant pathogens. Herein we present a
      review about the biological features of virion-associated lysins and endolysins,
      phage-derived enzymes that have naturally evolved to compromise the bacterial
      peptidoglycan from without and from within, respectively. These natural features
      may determine the adaptability of the enzymes to kill bacteria in different
      environments. Endolysins are by far the most studied group of peptidoglycan
      degrading enzymes, with several studies showing that they can exhibit potent
      antibacterial activity under specific conditions. However, the lytic activity of
      most endolysins seems to be significantly reduced when tested against actively
      growing bacteria, something that may be related to fact that these enzymes are
      naturally designed to degrade the peptidoglycan from within dead cells. This may
      negatively impact the efficacy of the endolysin in treating some infections in
      vivo. Here, we present a critical view of the methods commonly used to evaluate
      in vitro and in vivo the antibacterial performance of PG-degrading enzymes,
      focusing on the major hurdles concerning in vitro-to-in vivo translation.

PMID- 29844289
TI  - Sexual Risk Behaviors of Patients with HIV/AIDS over the Course of Antiretroviral
      Treatment in Northern Vietnam.
AB  - Antiretroviral therapy (ART) improves the health and well-being of people living
      with the human immunodeficiency virus (HIV, PLWH), and reduces their risk of
      transmitting the virus to sexual partners. However, patterns of sexual risk
      behavior among HIV-positive patients taking ART in Vietnam remain largely
      unknown. In this study, we sought to examine sexual risk behaviors and their
      associated factors among HIV-positive patients receiving ART in northern Vietnam.
      The socio-demographic characteristics, ART use, health status, and sexual
      behaviors of 1133 patients taking ART in the Hanoi and Nam Dinh provinces were
      explored through face-to-face interviews. There were 63.5% of patients who had
      one sex partner, while 3.6% and 5.6% of patients had sexual intercourse with
      casual partners or sex workers, respectively, in the previous 12 months. Most
      participants tended to use condoms more often with commercial sex partners
      (90.2%) and intimate partners (79.7%), and less often with casual partners
      (60.9%). Higher age (odds ratio, OR = 1.0; 95% CIs = 1.0, 1.1) or suffering
      pain/discomfort (OR = 1.7; 95% CIs = 1.2, 2.4) were factors more likely to be
      associated with multiple sex partners. Patients who were self-employed were more
      likely to have sexual intercourse with casual partners/sex workers (OR = 2.1; 95%
      CIs = 1.1, 4.0). Meanwhile, a higher score on the EuroQol visual analog scale (EQ
      VAS), an unknown HIV stage, and a longer duration of ART were adversely
      associated with not using condoms with casual partners/sex workers. Patients with
      longer durations of ART had a lower likelihood of not using a condom with casual
      partners/sex workers (OR = 0.5; 95% CIs = 0.3, 0.8). Our study underscored a
      relatively high rate of unsafe sexual behaviors among HIV-positive patients.
      Continuing to improve the physical and psychological well-being of HIV-positive
      patients in Vietnam is important in reducing the spread of HIV via risky sexual
      behaviors. In addition, safe-sex education should be provided to older people,
      and to those who are self-employed.

PMID- 29844288
TI  - The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased
      Nocturnal Melatonin Synthesis.
AB  - In mammals, a master clock is located within the suprachiasmatic nucleus (SCN) of
      the hypothalamus, a region that receives input from the retina that is
      transmitted by the retinohypothalamic tract. The SCN controls the nocturnal
      synthesis of melatonin by the pineal gland that can influence the activity of the
      clock's genes and be involved in the inhibition of cancer development. On the
      other hand, in the literature, some papers highlight that artificial light
      exposure at night (LAN)-induced circadian disruptions promote cancer. In the
      present review, we summarize the potential mechanisms by which LAN-evoked
      disruption of the nocturnal increase in melatonin synthesis counteracts its
      preventive action on human cancer development and progression. In detail, we
      discuss: (i) the Warburg effect related to tumor metabolism modification; (ii)
      genomic instability associated with L1 activity; and (iii) regulation of
      immunity, including regulatory T cell (Treg) regulation and activity. A better
      understanding of these processes could significantly contribute to new treatment
      and prevention strategies against hormone-related cancer types.

PMID- 29844290
TI  - Functioning and Disability Profile of Children with Microcephaly Associated with
      Congenital Zika Virus Infection.
AB  - INTRODUCTION: The increase in the number of cases of microcephaly in Brazil and
      its association with the Zika virus (ZIKV) is a global public health problem. The
      International Classification of Functioning Disability and Health (ICF) model is
      a powerful tool and extremely relevant in managing disability. OBJECTIVE:
      Describe the functioning profile of children with microcephaly associated with
      ZIKV in two states of northeastern Brazil. METHODS: This is a descriptive cross
      sectional study. The sociodemographic characteristics, head circumference, and
      other clinical data were collected from medical charts, physical examinations,
      measuring instruments, and interviews with the children and their parents. The
      Brazilian Portuguese version of the Brief Common ICF Core Set for cerebral palsy
      (CP) was used. Each ICF category was assigned a qualifier, which ranged from 0 to
      4 (no problem, mild problem, moderate problem, severe problem, complete problem).
      For environmental factors, 0 represents no barrier and 4 represents complete
      barrier; +0, no facilitator and +4, complete facilitator. RESULTS: A total of 34
      children with microcephaly caused by ZIKV were recruited (18 girls and 16 boys)
      at four rehabilitation facilities in Rio Grande do Norte and Paraiba states,
      Brazil. The average age of the participants was 21 months, monthly income was
      ~USD 300.00, and head circumference z-scores ranged between 0.92 and -5.51. The
      functioning profile revealed complete disability in most of the body function
      categories (b). The activity and participation areas (d) were highly impacted,
      particularly in mobility-related categories. With respect to environmental
      factors (e), most of the sample reported a complete facilitator for the immediate
      family, friends, and health services, systems, and policies, as well as a
      complete barrier to societal attitudes. CONCLUSION: This is the first study that
      describes the functioning profile of children with microcephaly associated with
      ZIKV, using a tool based on the ICF in Brazil. Our findings reinforce the need to
      maximize health care and access to information, based on the ICF, for
      multiprofessional teams, administrators, family members, and children.

PMID- 29844291
TI  - A Sensitive and Rapid Method to Determin the Adhesion Capacity of Probiotics and
      Pathogenic Microorganisms to Human Gastrointestinal Mucins.
AB  - Mucus is the habitat for the microorganisms, bacteria and yeast that form the
      commensal flora. Mucins, the main macromolecules of mucus, and more specifically,
      the glycans that cover them, play essential roles in microbial gastrointestinal
      colonization. Probiotics and pathogens must also colonize mucus to have lasting
      positive or deleterious effects. The question of which mucin-harboured glycan
      motifs favour the adhesion of specific microorganisms remains very poorly
      studied. In the current study, a simple test based on the detection of
      fluorescent-labeled microorganisms raised against microgram amounts of mucins
      spotted on nitrocellulose was developed. The adhesion of various probiotic,
      commensal and pathogenic microorganisms was evaluated on a panel of human
      purified gastrointestinal mucins and compared with that of commercially available
      pig gastric mucins (PGM) and of mucins secreted by the colonic cancer cell line
      HT29-MTX. The latter two proved to be very poor indicators of adhesion capacity
      on intestinal mucins. Our results show that the nature of the sialylated cores of
      O-glycans, determined by MALDI MS-MS analysis, potentially enables sialic acid
      residues to modulate the adhesion of microorganisms either positively or
      negatively. Other identified factors affecting the adhesion propensity were O
      glycan core types and the presence of blood group motifs. This test should help
      to select probiotics with enhanced adhesion capabilities as well as deciphering
      the role of specific mucin glycotopes on microbial adhesion.

PMID- 29844292
TI  - Smart Sensing Technologies for Personalised e-Coaching.
AB  - People living in both developed and developing countries face serious health
      challenges related to sedentary lifestyles. It is therefore essential to find new
      ways to improve health so that people can live longer and age well. With an ever
      growing number of smart sensing systems developed and deployed across the globe,
      experts are primed to help coach people to have healthier behaviors. The
      increasing accountability associated with app- and device-based behavior tracking
      not only provides timely and personalized information and support, but also gives
      us an incentive to set goals and do more. This paper outlines some of the recent
      efforts made towards automatic and autonomous identification and coaching of
      troublesome behaviors to procure lasting, beneficial behavioral changes.

PMID- 29844293
TI  - Magnetic Photocatalyst BiVO4/Mn-Zn ferrite/Reduced Graphene Oxide: Synthesis
      Strategy and Its Highly Photocatalytic Activity.
AB  - Magnetic photocatalyst BiVO4/Mn-Zn ferrite (Mn1-xZnxFe2O4)/reduced graphene oxide
      (RGO) was synthesized by a simple calcination and reduction method. The magnetic
      photocatalyst held high visible light-absorption ability with low band gap energy
      and wide absorption wavelength range. Electrochemical impedance spectroscopies
      illustrated good electrical conductivity which indicated low charge-transfer
      resistance due to incorporation of Mn1-xZnxFe2O4 and RGO. The test of
      photocatalytic activity showed that the degradation ratio of rhodamine B (RhB)
      reached 96.0% under visible light irradiation after only 1.5 h reaction. The
      photocatalytic mechanism for the prepared photocatalyst was explained in detail.
      Here, the incorporation of RGO enhanced the specific surface area compared with
      BiVO4/Mn1-xZnxFe2O4.The larger specific surface area provided more active surface
      sites, more free space to improve the mobility of photo-induced electrons, and
      further facilitated the effective migration of charge carriers, leading to the
      remarkable improvement of photocatalytic performance. Meanwhile, RGO was the
      effective acceptor as well as transporter of photo-generated electron hole pairs.
      *O2- was the most active species in the photocatalytic reaction. BiVO4/Mn1
      xZnxFe2O4/RGO had quite a wide application in organic contaminants removal or
      environmental pollution control.

PMID- 29844294
TI  - Supervoxels-Based Histon as a New Alzheimer's Disease Imaging Biomarker.
AB  - Alzheimer's disease (AD) represents the prevalent type of dementia in the
      elderly, and is characterized by the presence of neurofibrillary tangles and
      amyloid plaques that eventually leads to the loss of neurons, resulting in
      atrophy in specific brain areas. Although the process of degeneration can be
      visualized through various modalities of medical imaging and has proved to be a
      valuable biomarker, the accurate diagnosis of Alzheimer's disease remains a
      challenge, especially in its early stages. In this paper, we propose a novel
      classification method for Alzheimer's disease/cognitive normal discrimination in
      structural magnetic resonance images (MRI), based on the extension of the concept
      of histons to volumetric images. The proposed method exploits the relationship
      between grey matter, white matter and cerebrospinal fluid degeneration by means
      of a segmentation using supervoxels. The calculated histons are then processed
      for a reduction in dimensionality using principal components analysis (PCA) and
      the resulting vector is used to train an support vector machine (SVM) classifier.
      Experimental results using the OASIS-1 database have proven to be a significant
      improvement compared to a baseline classification made using the pipeline
      provided by Clinica software.

PMID- 29844296
TI  - Estimating Angle-of-Arrival and Time-of-Flight for Multipath Components Using
      WiFi Channel State Information.
AB  - Channel state information (CSI) collected during WiFi packet transmissions can be
      used for localization of commodity WiFi devices in indoor environments with
      multipath propagation. To this end, the angle of arrival (AoA) and time of flight
      (ToF) for all dominant multipath components need to be estimated. A two
      dimensional (2D) version of the multiple signal classification (MUSIC) algorithm
      has been shown to solve this problem using 2D grid search, which is
      computationally expensive and is therefore not suited for real-time localisation.
      In this paper, we propose using a modified matrix pencil (MMP) algorithm instead.
      Specifically, we show that the AoA and ToF estimates can be found independently
      of each other using the one-dimensional (1D) MMP algorithm and the results can be
      accurately paired to obtain the AoA-ToF pairs for all multipath components. Thus,
      the 2D estimation problem reduces to running 1D estimation multiple times,
      substantially reducing the computational complexity. We identify and resolve the
      problem of degenerate performance when two or more multipath components have the
      same AoA. In addition, we propose a packet aggregation model that uses the CSI
      data from multiple packets to improve the performance under noisy conditions.
      Simulation results show that our algorithm achieves two orders of magnitude
      reduction in the computational time over the 2D MUSIC algorithm while achieving
      similar accuracy. High accuracy and low computation complexity of our approach
      make it suitable for applications that require location estimation to run on
      resource-constrained embedded devices in real time.

PMID- 29844298
TI  - Accurate Fall Detection in a Top View Privacy Preserving Configuration.
AB  - Fall detection is one of the most investigated themes in the research on
      assistive solutions for aged people. In particular, a false-alarm-free
      discrimination between falls and non-falls is indispensable, especially to assist
      elderly people living alone. Current technological solutions designed to monitor
      several types of activities in indoor environments can guarantee absolute privacy
      to the people that decide to rely on them. Devices integrating RGB and depth
      cameras, such as the Microsoft Kinect, can ensure privacy and anonymity, since
      the depth information is considered to extract only meaningful information from
      video streams. In this paper, we propose an accurate fall detection method
      investigating the depth frames of the human body using a single device in a top
      view configuration, with the subjects located under the device inside a room.
      Features extracted from depth frames train a classifier based on a binary support
      vector machine learning algorithm. The dataset includes 32 falls and 8 activities
      considered for comparison, for a total of 800 sequences performed by 20 adults.
      The system showed an accuracy of 98.6% and only one false positive.

PMID- 29844295
TI  - Contact Allergy: A Review of Current Problems from a Clinical Perspective.
AB  - Contact allergy is common, affecting 27% of the general population in Europe.
      Original publications, including case reports, published since 2016 (inclusive)
      were identified with the aim of collating a full review of current problems in
      the field. To this end, a literature search employing methods of systematic
      reviewing was performed in the Medline(r) and Web of ScienceTM databases on 28
      January 2018, using the search terms ("contact sensitization" or "contact
      allergy"). Of 446 non-duplicate publications identified by above search, 147 were
      excluded based on scrutiny of title, abstract and key words. Of the remaining 299
      examined in full text, 291 were deemed appropriate for inclusion, and main
      findings were summarised in topic sections. In conclusion, diverse sources of
      exposures to chemicals of widely-differing types and structures, continue to
      induce sensitisation in man and may result in allergic contact dermatitis. Many
      of the chemicals are "evergreen" but others are "newcomers". Vigilance and proper
      investigation (patch testing) are required to detect and inform of the presence
      of these haptens to which our populations remain exposed.

PMID- 29844297
TI  - Immunotherapy for Gastric Cancer: Time for a Personalized Approach?
AB  - Over the last decade, our understanding of the mechanisms underlying immune
      modulation has greatly improved, allowing for the development of multiple
      therapeutic approaches that are revolutionizing the treatment of cancer.
      Immunotherapy for gastric cancer (GC) is still in the early phases but is rapidly
      evolving. Recently, multi-platform molecular analyses of GC have proposed a new
      classification of this heterogeneous group of tumors, highlighting subset
      specific features that may more reliably inform therapeutic choices, including
      the use of new immunotherapeutic drugs. The clinical benefit and improved
      survival observed in GC patients treated with immunotherapeutic strategies and
      their combination with conventional therapies highlighted the importance of the
      immune environment surrounding the tumor. A thorough investigation of the tumor
      microenvironment and the complex and dynamic interaction between immune cells and
      tumor cells is a fundamental requirement for the rational design of novel and
      more effective immunotherapeutic approaches. This review summarizes the pre
      clinical and clinical results obtained so far with immunomodulatory and
      immunotherapeutic treatments for GC and discusses the novel combination
      strategies that are being investigated to improve the personalization and
      efficacy of GC immunotherapy.

PMID- 29844299
TI  - Size and Content of the Sex-Determining Region of the Y Chromosome in Dioecious
      Mercurialis annua, a Plant with Homomorphic Sex Chromosomes.
AB  - Dioecious plants vary in whether their sex chromosomes are heteromorphic or
      homomorphic, but even homomorphic sex chromosomes may show divergence between
      homologues in the non-recombining, sex-determining region (SDR). Very little is
      known about the SDR of these species, which might represent particularly early
      stages of sex-chromosome evolution. Here, we assess the size and content of the
      SDR of the diploid dioecious herb Mercurialis annua, a species with homomorphic
      sex chromosomes and mild Y-chromosome degeneration. We used RNA sequencing
      (RNAseq) to identify new Y-linked markers for M. annua. Twelve of 24 transcripts
      showing male-specific expression in a previous experiment could be amplified by
      polymerase chain reaction (PCR) only from males, and are thus likely to be Y
      linked. Analysis of genome-capture data from multiple populations of M. annua
      pointed to an additional six male-limited (and thus Y-linked) sequences. We used
      these markers to identify and sequence 17 sex-linked bacterial artificial
      chromosomes (BACs), which form 11 groups of non-overlapping sequences, covering a
      total sequence length of about 1.5 Mb. Content analysis of this region suggests
      that it is enriched for repeats, has low gene density, and contains few candidate
      sex-determining genes. The BACs map to a subset of the sex-linked region of the
      genetic map, which we estimate to be at least 14.5 Mb. This is substantially
      larger than estimates for other dioecious plants with homomorphic sex
      chromosomes, both in absolute terms and relative to their genome sizes. Our data
      provide a rare, high-resolution view of the homomorphic Y chromosome of a
      dioecious plant.

PMID- 29844300
TI  - Multidirectional Efficacy of Biologically Active Nitro Compounds Included in
      Medicines.
AB  - The current concept in searching for new bioactive products, including mainly
      original active substances with potential application in pharmacy and medicine,
      is based on compounds with a previously determined structure, well-known
      properties, and biological activity profile. Nowadays, many commonly used drugs
      originated from natural sources. Moreover, some natural materials have become the
      source of leading structures for processing further chemical modifications. Many
      organic compounds with great therapeutic significance have the nitro group in
      their structure. Very often, nitro compounds are active substances in many well
      known preparations belonging to different groups of medicines that are classified
      according to their pharmacological potencies. Moreover, the nitro group is part
      of the chemical structure of veterinary drugs. In this review, we describe many
      bioactive substances with the nitro group, divided into ten categories, including
      substances with exciting activity and that are currently undergoing clinical
      trials.

PMID- 29844301
TI  - Vibration-Induced Errors in MEMS Tuning Fork Gyroscopes with Imbalance.
AB  - This paper discusses the vibration-induced error in non-ideal MEMS tuning fork
      gyroscopes (TFGs). Ideal TFGs which are thought to be immune to vibrations do not
      exist, and imbalance between two gyros of TFGs is an inevitable phenomenon. Three
      types of fabrication imperfections (i.e., stiffness imbalance, mass imbalance,
      and damping imbalance) are studied, considering different imbalance radios. We
      focus on the coupling types of two gyros of TFGs in both drive and sense
      directions, and the vibration sensitivities of four TFG designs with imbalance
      are simulated and compared. It is found that non-ideal TFGs with two gyros
      coupled both in drive and sense directions (type CC TFGs) are the most
      insensitive to vibrations with frequencies close to the TFG operating
      frequencies. However, sense-axis vibrations with in-phase resonant frequencies of
      a coupled gyros system result in severe error outputs to TFGs with two gyros
      coupled in the sense direction, which is mainly attributed to the sense
      capacitance nonlinearity. With increasing stiffness coupled ratio of the coupled
      gyros system, the sensitivity to vibrations with operating frequencies is cut
      down, yet sensitivity to vibrations with in-phase frequencies is amplified.

PMID- 29844303
TI  - Evaluation of Fine Aggregate Morphology by Image Method and Its Effect on Skid
      Resistance of Micro-Surfacing.
AB  - Micro-surfacing is a widely used pavement preventive maintenance technology used
      all over the world, due to its advantages of fast construction, low maintenance
      cost, good waterproofness, and skid-resistance performance. This study evaluated
      the fine aggregate morphology and surface texture of micro-surfacing by AIMS
      (aggregate image measurement system), and explored the effect of aggregate
      morphology on skid-resistance of single-grade micro-surfacing. Sand patch test
      and British pendulum test were also used to detect skid-resistance for comparison
      with the image-based method. Wet abrasion test was used to measure skid
      resistance durability for feasibility verification of single-grade micro
      surfacing. The results show that the effect of Form2D on the skid-resistance of
      micro-surfacing is much stronger than that of angularity. Combining the
      feasibility analysis of durability and skid-resistance, 1.18-2.36 grade micro
      surfacing meets the requirements of durability and skid-resistance at the same
      time. This study also determined that, compared with British pendulum test, the
      texture result obtained by sand patch test fits better with results of image
      method.

PMID- 29844302
TI  - The Human Health Assessment to Phthalate Acid Esters (PAEs) and Potential
      Probability Prediction by Chromophoric Dissolved Organic Matter EEM-FRI
      Fluorescence in Erlong Lake.
AB  - Phthalate acid esters (PAEs) are suspected to cause wide environmental pollution
      and have adverse effects on human health. Three priority control phthalates,
      namely dimethyl phthalate (DMP), diethyl phthalate (DEP), and dibutyl phthalate
      (DBP), were determined in 45 water samples from the largest drinking water source
      in Jilin Province. Chromophoric-dissolved organic matter (CDOM), which are
      composed of complex compounds and are a proxy for water quality, can be monitored
      using a fluorometer. This study attempted to understand the correlations of the
      CDOM fluorescence regional integration (FRI) components with PAEs and CDOM
      characteristics under seasonal and spatial variations in the Erlong Lake. The
      characteristics of the CDOM absorption parameters in different water samples
      showed a higher aromatic content and molecular weight in October because of
      increased terrestrial inputs. The Sigma3PAEs concentrations ranged from 0.231 mg
      L-1 to 0.435 mg L-1 in water, and DEP contributed to more than 90% of the
      Sigma3PAEs. The FRI method identified five fluorescence components: one tyrosine
      like (R1), one tryptophan-like (R2), one fulvic-like (R3), one microbial protein
      like (R4), and one humic-like (R5) component. However, significant relationships
      exist between DEP and R3 (R2 = 0.78, p < 0.001), R4 (R2 = 0.77, p < 0.001), and
      R5 (R2 = 0.58, p < 0.001). Quantifying the relationship between CDOM and PAEs was
      highly significant, because the results will simplify the componential analysis
      of pollutants from a spatiotemporal perspective as compared to traditional
      chemical measurements. The human health risk assessment results revealed no human
      health risk (HQ < 1) in the Erlong Lake basin.

PMID- 29844304
TI  - Alleviation of Acute Lung Injury in Rats with Sepsis by Resveratrol via the
      Phosphatidylinositol 3-Kinase/Nuclear Factor-Erythroid 2 Related Factor 2/Heme
      Oxygenase-1 (PI3K/Nrf2/HO-1) Pathway.
AB  - BACKGROUND Resveratrol (Res) is a type of polyphenol found in many plants, which
      can protect important organs from the damage induced by sepsis. However, the
      exact mechanism of its protective effect has not been established. This study
      investigated the effect of Res on the PI3K/Nrf2/HO-1 signaling pathway in rats
      with sepsis-induced acute lung injury (ALI). MATERIAL AND METHODS Male Wistar
      rats were treated with 30 mg/kg Res by intraperitoneal administration for 1 hour
      immediately after cecal ligation and puncture. Levels of MIP-2, IL-18, and IL-10
      in bronchoalveolar lavage fluid (BALF) were determined. Lung tissues were
      collected to measure the wet-to-dry (W/D) ratios, oxidative stress index, and
      lung injury scores. Expression levels of Akt, p-Akt, HO-1, Nrf-2, and active
      caspase-3 proteins were determined by western blotting; expression of HO-1 mRNA
      was determined by RT-PCR. RESULTS Treatment with Res significantly decreased the
      levels of MIP-2 and IL-18 and increased IL-10 in the BALF of rats with sepsis
      induced ALI. In addition, Res also effectively reduced the W/D lung weight ratio,
      lung injury score, and the levels of MDA (malondialdehyde) and 8-OHdG.
      Conversely, Res increased SOD (superoxide dismutase) activity in the lung tissue.
      Moreover, Res significantly induced higher HO-1 mRNA expression, upregulated HO-1
      and Nrf-2 protein expression, and the phosphorylation of Akt in the lung tissue.
      In contrast, the levels of activated caspase-3 protein were decreased in Res
      treated rats (P<0.05). CONCLUSIONS Res could inhibit inflammation, oxidative
      stress, and cell apoptosis to alleviate ALI in septic rats through the inhibition
      of the PI3K/Nrf2/HO-1 signaling pathway.

PMID- 29844305
TI  - Silent Neoplastic Cardiac Invasion in Small Cell Lung Cancer: A Case Report and
      Review of the Literature.
AB  - BACKGROUND Secondary malignant tumor of the heart is one of the most life
      threatening complications of lung cancer. Several published case reports have
      documented non-small cell lung cancer (NSCLC) patients with neoplastic cardiac
      invasion. However, the number of reported cases of small cell lung cancer (SCLC)
      with neoplastic cardiac invasion is limited. CASE REPORT We present a rare case
      of advanced SCLC in a patient with asymptomatic neoplastic cardiac invasion. We
      also discuss radiation therapy modalities that should be considered in SCLC
      patients with cardiac invasion. CONCLUSIONS Clinicians should be vigilant about
      cases of SCLC with asymptomatic intra-cardiac invasion and practice caution when
      diagnosing, as well as treating with radiation as a monotherapy.

PMID- 29844306
TI  - S100A11 protects against neuronal cell apoptosis induced by cerebral ischemia via
      inhibiting the nuclear translocation of annexin A1.
AB  - The subcellular location of annexin A1 (ANXA1) determines the ultimate fate of
      neurons after ischemic stroke. ANXA1 nuclear translocation is involved in
      neuronal apoptosis after cerebral ischemia, and extracellular ANXA1 is also
      associated with regulation of inflammatory responses. As the factors and
      mechanism that influence ANXA1 subcellular translocation remain unclear, studies
      aiming to determine and clarify the role of ANXA1 as a cell fate 'regulator'
      within cells are critically needed. In this study, we found that
      intracerebroventricular injection of the recombinant adenovirus vector Ad-S100A11
      (carrying S100A11) strongly improved cognitive function and induced robust
      neuroprotective effects after ischemic stroke in vivo. Furthermore, upregulation
      of S100A11 protected against neuronal apoptosis induced by oxygen-glucose
      deprivation and reoxygenation (OGD/R) in vitro. Surprisingly, S100A11
      overexpression markedly decreased ANXA1 nuclear translocation and subsequently
      alleviated OGD/R-induced neuronal apoptosis. Notably, S100A11 exerted its
      neuroprotective effect by directly binding ANXA1. Importantly, S100A11 directly
      interacted with ANXA1 through the nuclear translocation signal (NTS) of ANXA1,
      which is essential for ANXA1 to import into the nucleus. Consistent with our
      previous studies, ANXA1 nuclear translocation after OGD/R promoted p53
      transcriptional activity, induced mRNA expression of the pro-apoptotic Bid gene,
      and activated the caspase-3 apoptotic pathway, which was almost completely
      reversed by S100A11 overexpression. Thus, S100A11 protects against cell apoptosis
      by inhibiting OGD/R-induced ANXA1 nuclear translocation. This study provides a
      novel mechanism whereby S100A11 protects against neuronal cells apoptosis,
      suggesting the potential for a previously unidentified treatment strategy in
      minimizing apoptosis after ischemic stroke.

PMID- 29844307
TI  - miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance
      through the direct targeting of YAP.
AB  - Although evidence has emerged to suggest that YAP overexpression is a crucial
      factor for tumor progression and resistance to targeted drugs in multiple
      cancers, the miRNA-mediated YAP regulation is still unclear. Here we show that
      the novel miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor
      resistance through the direct targeting of YAP. Our data showed that the miR-550a
      3-5p suppressed cell proliferation, metastasis, and tumor sphere formation
      through the direct inhibition of YAP and its oncogenic pathway in various cancer
      cell types. In addition, we showed that the YAP signature was associated with
      poor survival of colon cancer and identified an inverse correlation between miR
      550a-3-5p and YAP in colon cancer tissues. Interestingly, this inverse
      correlation was regulated in a density-dependent manner. Furthermore, high levels
      of miR-550a-3-5p were associated with a good prognosis of esophageal cancer,
      which was suggestive of the clinical relevance of miR-550a-3-5p-mediated YAP
      regulation in multiple cancers. Importantly, we demonstrated that miR-550a-3-5p
      treatment sensitized vemurafenib-resistant colon and melanoma cells through YAP
      inhibition with reduced AKT activity. Moreover, the tumor-suppressive activity of
      miR-550a-3-5p and its sensitization effect for vemurafenib resistance were also
      observed in tumor xenograft models. Collectively, our data suggest that miR-550a
      3-5p acts as a tumor suppressor through the targeting of oncogenic YAP and may be
      a new therapeutic tool for YAP-mediated BRAF inhibitor resistance in BRAF-mutant
      cancer cells.

PMID- 29844308
TI  - Observation of different reactivities of para and ortho-water towards trapped
      diazenylium ions.
AB  - Water is one of the most fundamental molecules in chemistry, biology and
      astrophysics. It exists as two distinct nuclear-spin isomers, para- and ortho
      water, which do not interconvert in isolated molecules. The experimental
      challenges in preparing pure samples of the two isomers have thus far precluded a
      characterization of their individual chemical behavior. Capitalizing on recent
      advances in the electrostatic deflection of polar molecules, we separate the
      ground states of para- and ortho-water in a molecular beam to show that the two
      isomers exhibit different reactivities in a prototypical reaction with trapped
      diazenylium ions. Based on ab initio calculations and a modelling of the reaction
      kinetics using rotationally adiabatic capture theory, we rationalize this finding
      in terms of different rotational averaging of ion-dipole interactions during the
      reaction.

PMID- 29844309
TI  - FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating
      the focal adhesion signalling pathway.
AB  - Follistatin-like protein 1 (FSTL1) has been reported to have both tumour
      promoting and tumour-suppressive characters. However, the role of FSTL1 in
      colorectal cancer (CRC) remains unclear. Here we showed that FSTL1 expression was
      significantly up-regulated in CRC tissues compared with the paired normal
      tissues. In addition, the higher FSTL1 expression was associated with the
      infiltrating depth, lymph node metastasis and poor prognosis of CRC. Enhanced
      expression of FSTL1 distinctly increased cell migration and invasion in vitro, as
      well as promoting liver metastasis of CRC in vivo. Conversely, knockdown of FSTL1
      expression significantly repressed invasion and metastasis of CRC. Mechanically,
      transcription factor Smad3 was involved in FSTL1 protein expression inducing by
      TGFbeta1-Smad2/3 signalling. Furthermore, this effect of FSTL1 in promoting CRC
      progression was actualised via activating focal adhesions signalling pathway and
      regulating cytoskeleton rearrangement. We identified VIM, as an interactive
      protein of FSTL1, participated in FSTL1-mediated aggressive phenotype. We showed
      the role of FSTL1 in CRC and explored its transcription regulation and downstream
      signalling molecular mechanisms. In conclusion, our findings suggested that FSTL1
      promoted CRC progression and metastasis, making it a novel target for diagnosis
      and prognostic evaluation of CRC.

PMID- 29844310
TI  - Budding-like division of all-aqueous emulsion droplets modulated by networks of
      protein nanofibrils.
AB  - Networks of natural protein nanofibrils, such as cytoskeletal filaments, control
      the shape and the division of cells, yet mimicking this functionality in a
      synthetic setting has proved challenging. Here, we demonstrate that artificial
      networks of protein nanofibrils can induce controlled deformation and division of
      all-aqueous emulsion droplets with budding-like morphologies. We show that this
      process is driven by the difference in the immersional wetting energy of the
      nanofibril network, and that both the size and the number of the daughter
      droplets formed during division can be controlled by modulating the fibril
      concentration and the chemical properties of the fibril network. Our results
      demonstrate a route for achieving biomimetic division with synthetic self
      assembling fibrils and offer an engineered approach to regulate the morphology of
      protein gels.

PMID- 29844311
TI  - Interfacial photochemistry at the ocean surface is a global source of organic
      vapors and aerosols.
AB  - The surface of the oceans acts as a global sink and source for trace gases and
      aerosol particles. Recent studies suggest that photochemical reactions at this
      air/water interface produce organic vapors, enhancing particle formation in the
      atmosphere. However, current model calculations neglect this abiotic source of
      reactive compounds and account only for biological emissions. Here we show that
      interfacial photochemistry serves as a major abiotic source of volatile organic
      compounds (VOCs) on a global scale, capable to compete with emissions from marine
      biology. Our results indicate global emissions of 46.4-184 Tg C yr-1 of organic
      vapors from the oceans into the marine atmosphere and a potential contribution to
      organic aerosol mass of more than 60% over the remote ocean. Moreover, we provide
      global distributions of VOC formation potentials, which can be used as simple
      tools for field studies to estimate photochemical VOC emissions depending on
      location and season.

PMID- 29844312
TI  - Are autonomous cities our urban future?
AB  - Cities are rapidly expanding in size, wealth and power, with some now larger than
      nation states. Smart city solutions and strong global urban networks are
      developing to manage massive urban growth. However, cities exist within a wider
      system and it may take more than technological advances, innovation and city
      autonomy to develop a sustainable urban future.

PMID- 29844313
TI  - Inharmonic speech reveals the role of harmonicity in the cocktail party problem.
AB  - The "cocktail party problem" requires us to discern individual sound sources from
      mixtures of sources. The brain must use knowledge of natural sound regularities
      for this purpose. One much-discussed regularity is the tendency for frequencies
      to be harmonically related (integer multiples of a fundamental frequency). To
      test the role of harmonicity in real-world sound segregation, we developed speech
      analysis/synthesis tools to perturb the carrier frequencies of speech, disrupting
      harmonic frequency relations while maintaining the spectrotemporal envelope that
      determines phonemic content. We find that violations of harmonicity cause
      individual frequencies of speech to segregate from each other, impair the
      intelligibility of concurrent utterances despite leaving intelligibility of
      single utterances intact, and cause listeners to lose track of target talkers.
      However, additional segregation deficits result from replacing harmonic
      frequencies with noise (simulating whispering), suggesting additional grouping
      cues enabled by voiced speech excitation. Our results demonstrate acoustic
      grouping cues in real-world sound segregation.

PMID- 29844314
TI  - Superfluid motion and drag-force cancellation in a fluid of light.
AB  - Quantum fluids of light merge many-body physics and nonlinear optics, revealing
      quantum hydrodynamic features of light when it propagates in nonlinear media. One
      of the most outstanding evidence of light behaving as an interacting fluid is its
      ability to carry itself as a superfluid. Here, we report a direct experimental
      detection of the transition to superfluidity in the flow of a fluid of light past
      an obstacle in a bulk nonlinear crystal. In this cavityless all-optical system,
      we extract a direct optical analog of the drag force exerted by the fluid of
      light and measure the associated displacement of the obstacle. Both quantities
      drop to zero in the superfluid regime characterized by a suppression of long
      range radiation from the obstacle. The experimental capability to shape both the
      flow and the potential landscape paves the way for simulation of quantum
      transport in complex systems.

PMID- 29844315
TI  - The kinase receptor-interacting protein 1 is required for inflammasome activation
      induced by endoplasmic reticulum stress.
AB  - Endoplasmic reticulum (ER) stress contributes to the development and progression
      of many chronic inflammatory diseases, including type 2 diabetes, obesity,
      atherosclerosis, neurodegenerative diseases, and cancer. ER stress has been
      reported to induce inflammasome activation and release of mature IL-1beta, which
      contributes to many inflammatory diseases. The molecular mechanisms that activate
      the inflammasome during ER stress are still poorly understood. Here we report
      that the kinase receptor-interacting protein 1 (RIP1) plays an important role in
      ER stress-induced activation of inflammasome. Inhibition of RIP1 kinase activity
      by Necrostatin-1 or siRNA-mediated RIP1 knockdown significantly reduced ER stress
      induced caspase-1 cleavage and IL-1beta secretion in both bone marrow-derived
      macrophages (BMDMs) and J774A.1 macrophages. We speculate that the mitochondria
      fission factor dynamin-related protein 1 (DRP1) and reactive oxygen species (ROS)
      might function as the effectors downstream of RIP1 to mediate inflammasome
      activation. Our study reveals a critical role for RIP1 in regulating ER stress
      induced inflammation responses, and proposes RIP1 as a potential pharmaceutical
      target to treat diseases resulting from unresolved ER stress-related
      inflammation.

PMID- 29844316
TI  - Asymmetric transfer of CO2 across a broken sea surface.
AB  - Most estimates of the climatically-important transfer of atmospheric gases into,
      and out of, the ocean assume that the ocean surface is unbroken by breaking
      waves. However the trapping of bubbles of atmospheric gases in the ocean by
      breaking waves introduces an asymmetry in this flux. This asymmetry occurs as a
      bias towards injecting gas into the ocean where it dissolves, and against the
      evasion/exsolution of previously-dissolved gas coming out of solution from the
      oceans and eventually reaching the atmosphere. Here we use at-sea measurements
      and modelling of the bubble clouds beneath the ocean surface to show that the
      numbers of large bubbles found metres below the sea surface in high winds are
      sufficient to drive a large and asymmetric flux of carbon dioxide. Our results
      imply a much larger asymmetry for carbon dioxide than previously proposed. This
      asymmetry contradicts an assumption inherent in most existing estimates of ocean
      atmosphere gas transfer. The geochemical and climate implications include an
      enhanced invasion of carbon dioxide into the stormy temperate and polar seas.

PMID- 29844317
TI  - Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor
      draining lymph node.
AB  - CD4+ T cell antitumor responses have mostly been studied in transplanted tumors
      expressing secreted model antigens (Ags), while most mutated proteins in human
      cancers are not secreted. The fate of Ag-specific CD4+ T cells recognizing a
      cytoplasmic Ag in mice bearing autochthonous tumors is still unclear. Here we
      show, using a genetically engineered lung adenocarcinoma mouse model, that naive
      tumor-specific CD4+ T cells are activated and proliferate in the tumor-draining
      lymph node (TdLN) but do not differentiate into effectors or accumulate in
      tumors. Instead, these CD4+ T cells are driven toward anergy or peripherally
      induced Treg (pTreg) differentiation, from the early stage of tumor development.
      This bias toward immune suppression is restricted to the TdLN, and is maintained
      by Tregs enriched in the tumor Ag-specific cell population. Thus, tumors may
      enforce a dominant inhibition of the anti-tumor CD4 response in the TdLN by
      recapitulating peripheral self-tolerance mechanisms.

PMID- 29844318
TI  - A phase I single-blind clinical trial to evaluate the safety of oil palm
      phenolics (OPP) supplementation in healthy volunteers.
AB  - Plant phenolics are being increasingly consumed globally with limited scientific
      and clinical evidence pertaining to safety and efficacy. The oil palm fruit
      contains a cocktail of phenolics, and palm oil production results in high volumes
      of aqueous by-products enriched in phenolics and bioactives. Several lines of
      evidence from in vitro and in vivo animal studies confirmed that the aqueous
      extract enriched in phenolics and other bioactives collectively known as oil palm
      phenolics (OPP) is safe and has potent bioactivity. A phase one clinical trial
      was conducted to evaluate the safety and effects of OPP in healthy volunteers. In
      this single-blind trial, 25 healthy human volunteers were supplemented with 450
      mg gallic acid equivalent (GAE)/day of OPP or control treatments for a 60-day
      period. Fasting blood and urine samples were collected at days 1, 30 and 60.
      Medical examination was performed during these trial interventions. All clinical
      biochemistry profiles observed throughout the control and OPP treatment period
      were in the normal range with no major adverse effect (AE) or serious adverse
      effect (SAE) observed. Additionally, OPP supplementation resulted in improvement
      of total cholesterol and LDL-C levels, compared to the control treatment. The
      outcomes support our previous observations that OPP is safe and may have a
      protective role in reducing cholesterol levels.

PMID- 29844319
TI  - Mechanisms responsible for increased circulating levels of galectin-3 in
      cardiomyopathy and heart failure.
AB  - Galectin-3 is a biomarker of heart disease. However, it remains unknown whether
      increase in galectin-3 levels is dependent on aetiology or disease-associated
      conditions and whether diseased heart releases galectin-3 into the circulation.
      We explored these questions in mouse models of heart disease and in patients with
      cardiomyopathy. All mouse models (dilated cardiomyopathy, DCM; fibrotic
      cardiomyopathy, ischemia-reperfusion, I/R; treatment with beta-adrenergic agonist
      isoproterenol) showed multi-fold increases in cardiac galectin-3 expression and
      preserved renal function. In mice with fibrotic cardiomyopathy, I/R or
      isoproterenol treatment, plasma galectin-3 levels and density of cardiac
      inflammatory cells were elevated. These models also exhibited parallel changes in
      cardiac and plasma galectin-3 levels and presence of trans-cardiac galectin-3
      gradient, indicating cardiac release of galectin-3. DCM mice showed no change in
      circulating galectin-3 levels nor trans-cardiac galectin-3 gradient or myocardial
      inflammatory infiltration despite a 50-fold increase in cardiac galectin-3
      content. In patients with hypertrophic cardiomyopathy or DCM, plasma galectin-3
      increased only in those with renal dysfunction and a trans-cardiac galectin-3
      gradient was not present. Collectively, this study documents the aetiology
      dependency and diverse mechanisms of increment in circulating galectin-3 levels.
      Our findings highlight cardiac inflammation and enhanced beta-adrenoceptor
      activation in mediating elevated galectin-3 levels via cardiac release in the
      mechanism.

PMID- 29844320
TI  - Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome
      remodelling properties in a mutation-specific manner.
AB  - ATP-dependent chromatin remodellers are mutated in more than 20% of human
      cancers. The consequences of these mutations on enzyme function are poorly
      understood. Here, we characterise the effects of CHD4 mutations identified in
      endometrial carcinoma on the remodelling properties of dMi-2, the highly
      conserved Drosophila homologue of CHD4. Mutations from different patients have
      surprisingly diverse defects on nucleosome binding, ATPase activity and
      nucleosome remodelling. Unexpectedly, we identify both mutations that decrease
      and increase the enzyme activity. Our results define the chromodomains and a
      novel regulatory region as essential for nucleosome remodelling. Genetic
      experiments in Drosophila demonstrate that expression of cancer-derived dMi-2
      mutants misregulates differentiation of epithelial wing structures and produces
      phenotypes that correlate with their nucleosome remodelling properties. Our
      results help to define the defects of CHD4 in cancer at the mechanistic level and
      provide the basis for the development of molecular approaches aimed at restoring
      their activity.

PMID- 29844321
TI  - Exciton Relaxation Cascade in two-dimensional Transition Metal Dichalcogenides.
AB  - Monolayers of transition metal dichalcogenides (TMDs) are characterized by an
      extraordinarily strong Coulomb interaction giving rise to tightly bound excitons
      with binding energies of hundreds of meV. Excitons dominate the optical response
      as well as the ultrafast dynamics in TMDs. As a result, a microscopic
      understanding of exciton dynamics is the key for a technological application of
      these materials. In spite of this immense importance, elementary processes
      guiding the formation and relaxation of excitons after optical excitation of an
      electron-hole plasma has remained unexplored to a large extent. Here, we provide
      a fully quantum mechanical description of momentum- and energy-resolved exciton
      dynamics in monolayer molybdenum diselenide (MoSe2) including optical excitation,
      formation of excitons, radiative recombination as well as phonon-induced cascade
      like relaxation down to the excitonic ground state. Based on the gained insights,
      we reveal experimentally measurable features in pump-probe spectra providing
      evidence for the exciton relaxation cascade.

PMID- 29844322
TI  - Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRgamma
      coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic
      cells.
AB  - Plasmacytoid dendritic cells (pDCs) produce large amounts of type-I interferon
      (IFN) in response to viral infection or self nucleic acids. Leukocyte mono
      immunoglobulin-like receptor 8 (LMIR8), also called CMRF-35-like molecule-6 (CLM
      6), is a putative activating receptor among mouse LMIR/CLM/CD300 members;
      however, the expression and function of LMIR8 remain unclear. Here, we
      characterize mouse LMIR8 as a pDC receptor. Analysis of Flag-tagged LMIR8
      transduced bone marrow (BM)-derived mast cells demonstrated that LMIR8 can
      transmit an activating signal by interacting with immunoreceptor tyrosine-based
      activating motif (ITAM)-containing FcRgamma. Flow cytometric analysis using a
      specific antibody for LMIR8 showed that LMIR8 expression was restricted to mouse
      pDCs residing in BM, spleen, or lymph node. FcRgamma deficiency dampened surface
      expression of LMIR8 in mouse pDCs. Notably, LMIR8 was detected only in pDCs,
      irrespective of TLR9 stimulation, suggesting that LMIR8 is a suitable marker for
      pDCs in mouse tissues; LMIR8 is weakly expressed in Flt3 ligand-induced BM
      derived pDCs (BMpDCs). Crosslinking of transduced LMIR8 in BMpDCs with anti-LMIR8
      antibody did not induce IFN-alpha production, but rather suppressed TLR9-mediated
      production of IFN-alpha. Taken together, these observations indicate that LMIR8
      is an FcRgamma-coupled receptor selectively expressed in mouse tissue pDCs, which
      might suppress pDC activation through the recognition of its ligands.

PMID- 29844323
TI  - Naturally occurring a loss of a giant plasmid from Mycobacterium ulcerans subsp.
      shinshuense makes it non-pathogenic.
AB  - Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU), a WHO-defined
      neglected tropical disease. All Japanese BU causative isolates have shown
      distinct differences from the prototype and are categorized as M. ulcerans
      subspecies shinshuense. During repeated sub-culture, we found that some M.
      shinshuense colonies were non-pigmented whereas others were pigmented. Whole
      genome sequence analysis revealed that non-pigmented colonies did not harbor a
      giant plasmid, which encodes elements needed for mycolactone toxin biosynthesis.
      Moreover, mycolactone was not detected in sterile filtrates of non-pigmented
      colonies. Mice inoculated with suspensions of pigmented colonies died within 5
      weeks whereas those infected with suspensions of non-pigmented colonies had
      significantly prolonged survival (>8 weeks). This study suggests that mycolactone
      is a critical M. shinshuense virulence factor and that the lack of a mycolactone
      producing giant plasmid makes the strain non-pathogenic. We made an avirulent
      mycolactone-deletion mutant strain directly from the virulent original.

PMID- 29844324
TI  - Linking drug target and pathway activation for effective therapy using multi-task
      learning.
AB  - Despite the abundance of large-scale molecular and drug-response data, the
      insights gained about the mechanisms underlying treatment efficacy in cancer has
      been in general limited. Machine learning algorithms applied to those datasets
      most often are used to provide predictions without interpretation, or reveal
      single drug-gene association and fail to derive robust insights. We propose to
      use Macau, a bayesian multitask multi-relational algorithm to generalize from
      individual drugs and genes and explore the interactions between the drug targets
      and signaling pathways' activation. A typical insight would be: "Activation of
      pathway Y will confer sensitivity to any drug targeting protein X". We applied
      our methodology to the Genomics of Drug Sensitivity in Cancer (GDSC) screening,
      using gene expression of 990 cancer cell lines, activity scores of 11 signaling
      pathways derived from the tool PROGENy as cell line input and 228 nominal targets
      for 265 drugs as drug input. These interactions can guide a tissue-specific
      combination treatment strategy, for example suggesting to modulate a certain
      pathway to maximize the drug response for a given tissue. We confirmed in
      literature drug combination strategies derived from our result for brain, skin
      and stomach tissues. Such an analysis of interactions across tissues might help
      target discovery, drug repurposing and patient stratification strategies.

PMID- 29844326
TI  - Heart regeneration is regulates by key micro RNAs from fish to mammals: what it
      can learned about the epicardial cells activation during the regeneration in
      zebrafish.

PMID- 29844325
TI  - Combining amplicon sequencing and metabolomics in cirrhotic patients highlights
      distinctive microbiota features involved in bacterial translocation, systemic
      inflammation and hepatic encephalopathy.
AB  - In liver cirrhosis (LC), impaired intestinal functions lead to dysbiosis and
      possible bacterial translocation (BT). Bacteria or their byproducts within the
      bloodstream can thus play a role in systemic inflammation and hepatic
      encephalopathy (HE). We combined 16S sequencing, NMR metabolomics and network
      analysis to describe the interrelationships of members of the microbiota in LC
      biopsies, faeces, peripheral/portal blood and faecal metabolites with clinical
      parameters. LC faeces and biopsies showed marked dysbiosis with a heightened
      proportion of Enterobacteriaceae. Our approach showed impaired faecal bacterial
      metabolism of short-chain fatty acids (SCFAs) and carbon/methane sources in LC,
      along with an enhanced stress-related response. Sixteen species, mainly belonging
      to the Proteobacteria phylum, were shared between LC peripheral and portal blood
      and were functionally linked to iron metabolism. Faecal Enterobacteriaceae and
      trimethylamine were positively correlated with blood proinflammatory cytokines,
      while Ruminococcaceae and SCFAs played a protective role. Within the peripheral
      blood and faeces, certain species (Stenotrophomonas pavanii, Methylobacterium
      extorquens) and metabolites (methanol, threonine) were positively related to HE.
      Cirrhotic patients thus harbour a 'functional dysbiosis' in the faeces and
      peripheral/portal blood, with specific keystone species and metabolites related
      to clinical markers of systemic inflammation and HE.

PMID- 29844328
TI  - LncRNA MALAT1 promotes high glucose-induced inflammatory response of microglial
      cells via provoking MyD88/IRAK1/TRAF6 signaling.
AB  - Although a large number of studies have confirmed from multiple levels that
      diabetes mellitus (DM) promotes cerebral ischemic reperfusion (I/R) injury, but
      the precise mechanism is still unclear. A cerebral I/R injury model in diabetic
      rats was established. The neurological deficit scores and brain edema were
      monitored at 24 and 72 hours after injury. The peri-infarct cortical tissues of
      rats were isolated for molecular biology detection. The rat primary microglia and
      microglia line HAPI were cultured to establish the cell model of DM-I/R by high
      glucose (HG) and hypoxia-reoxygenation (H/R). The endogenous expression of MALAT1
      and MyD88 was regulated by the transfection with pcDNA-MALAT1, si-MALAT1 and si
      MyD88, respectively. The cerebral I/R injury model in diabetic rats had more
      severe neuronal injury as shown by the significantly higher neurological deficit
      scores and an obvious increasing brain edema at 24 and 72 hours after injury.
      Moreover, the microglia were activated and induced a large number of inflammatory
      cytokines TNF-alpha, IL-1beta and IL-6 in the peri-infarct cortical tissues
      during cerebral I/R injury associated with DM. The expression of MALAT1, MyD88,
      IRAK1 and TRAF6 protein were significantly up-regulated by DM-I/R in vitro and in
      vivo. Furthermore, the HG-H/R-induced MALAT1 promoted the inflammatory response
      in microglia via MyD88/IRAK1/TRAF6 signaling. Our results suggested that MALAT1
      mediated the exacerbation of cerebral I/R injury induced by DM through triggering
      the inflammatory response in microglia via MyD88 signaling.

PMID- 29844329
TI  - Fabrication and In Vitro Characterization of a Tissue Engineered PCL-PLLA Heart
      Valve.
AB  - Heart valve diseases are among the leading causes of cardiac failure around the
      globe. Nearly 90,000 heart valve replacements occur in the USA annually.
      Currently, available options for heart valve replacement include bioprosthetic
      and mechanical valves, both of which have severe limitations. Bioprosthetic
      valves can last for only 10-20 years while patients with mechanical valves always
      require blood-thinning medications throughout the remainder of the patient's
      life. Tissue engineering has emerged as a promising solution for the development
      of a viable, biocompatible and durable heart valve; however, a human implantable
      tissue engineered heart valve is yet to be achieved. In this study, a tri-leaflet
      heart valve structure is developed using electrospun polycaprolactone (PCL) and
      poly L-lactic acid (PLLA) scaffolds, and a set of in vitro testing protocol has
      been developed for routine manufacturing of tissue engineered heart valves.
      Stress-strain curves were obtained for mechanical characterization of different
      valves. The performances of the developed valves were hemodynamically tested
      using a pulse duplicator, and an echocardiography machine. Results confirmed the
      superiority of the PCL-PLLA heart valve compared to pure PCL or pure PLLA. The
      developed in vitro test protocol involving pulse duplicator and echocardiography
      tests have enormous potential for routine application in tissue engineering of
      heart valves.

PMID- 29844327
TI  - Interferon-gamma drives programmed death-ligand 1 expression on islet beta cells
      to limit T cell function during autoimmune diabetes.
AB  - Type 1 diabetes is caused by autoreactive T cell-mediated beta cell destruction.
      Even though co-inhibitory receptor programmed death-1 (PD-1) restrains
      autoimmunity, the expression and regulation of its cognate ligands on beta cell
      remains unknown. Here, we interrogated beta cell-intrinsic programmed death
      ligand-1 (PD-L1) expression in mouse and human islets. We measured a significant
      increase in the level of PD-L1 surface expression and the frequency of PD-L1+
      beta cells as non-obese diabetic (NOD) mice aged and developed diabetes.
      Increased beta cell PD-L1 expression was dependent on T cell infiltration, as
      beta cells from Rag1-deficient mice lacked PD-L1. Using Rag1-deficient NOD mouse
      islets, we determined that IFN-gamma promotes beta cell PD-L1 expression. We
      performed analogous experiments using human samples, and found a significant
      increase in beta cell PD-L1 expression in type 1 diabetic samples compared to
      type 2 diabetic, autoantibody positive, and non-diabetic samples. Among type 1
      diabetic samples, beta cell PD-L1 expression correlated with insulitis. In vitro
      experiments with human islets from non-diabetic individuals showed that IFN-gamma
      promoted beta cell PD-L1 expression. These results suggest that insulin-producing
      beta cells respond to pancreatic inflammation and IFN-gamma production by
      upregulating PD-L1 expression to limit self-reactive T cells.

PMID- 29844330
TI  - Molecular Diagnosis of 34 Japanese Families with Leber Congenital Amaurosis Using
      Targeted Next Generation Sequencing.
AB  - Leber congenital amaurosis (LCA) is a genetically and clinically heterogeneous
      disease, and represents the most severe form of inherited retinal dystrophy
      (IRD). The present study reports the mutation spectra and frequency of known LCA
      and IRD-associated genes in 34 Japanese families with LCA (including three
      families that were previously reported). A total of 74 LCA- and IRD-associated
      genes were analysed via targeted-next generation sequencing (TS), while recently
      discovered LCA-associated genes, as well as known variants not able to be
      screened using this approach, were evaluated via additional Sanger sequencing,
      long-range polymerase chain reaction, and/or copy number variation analyses. The
      results of these analyses revealed 30 potential pathogenic variants in 12 (nine
      LCA-associated and three other IRD-associated) genes among 19 of the 34 analysed
      families. The most frequently mutated genes were CRB1, NMNAT1, and RPGRIP1. The
      results also showed the mutation spectra and frequencies identified in the
      analysed Japanese population to be distinctly different from those previously
      identified for other ethnic backgrounds. Finally, the present study, which is the
      first to conduct a NGS-based molecular diagnosis of a large Japanese LCA cohort,
      achieved a detection rate of approximately 56%, indicating that TS is a valuable
      method for molecular diagnosis of LCA cases in the Japanese population.

PMID- 29844331
TI  - Less invasive surfactant administration and complications of preterm birth.
AB  - In a large cohort study of the German Neonatal Network (GNN) we aimed to evaluate
      whether less invasive surfactant administration (LISA) strategy is associated
      with complications of preterm birth. Within the observational period n = 7533
      very-low-birth-weight infants (VLBWI) with gestational age 22 0/7 to 28 6/7 weeks
      were enrolled in GNN; n = 1214 VLBWI never received surfactant, n = 2624 VLBWI
      were treated according to LISA procedure, n = 3695 VLBWI had surfactant via
      endotracheal tube (ETT). LISA was associated with a reduced risk for adverse
      outcome measures including mortality [odds ratio (OR) 0.66 (95% CI: 0.51-0.84), p
      < 0.001] bronchopulmonary dysplasia [BPD; OR 0.55 (95% CI: 0.49-0.62), p <
      0.001], intracerebral hemorrhage (ICH) grade II-IV [OR 0.55 (95% CI: 0.48-0.64),
      p < 0.001] and retinopathy of prematurity [ROP; OR 0.62 (95% CI: 0.45-0.85), p <
      0.001]. Notably, LISA was associated with an increased risk for focal intestinal
      perforation [FIP; OR 1.49 (95% CI: 1.14-1.95), p = 0.002]. The differences in FIP
      rates were primarily observed in VLBWI born <26 weeks (LISA: 10.0 vs. ETT: 7.4%,
      p = 0.029). Our observational data confirm that LISA is associated with improved
      outcome. In infants <26 weeks we noted an increased risk for FIP. Future
      randomized controlled trials including LISA need to integrate safety analyses for
      this particular subgroup.

PMID- 29844332
TI  - Does "a picture is worth 1000 words" apply to iconic Chinese words? Relationship
      of Chinese words and pictures.
AB  - The meaning of a picture can be extracted rapidly, but the form-to-meaning
      relationship is less obvious for printed words. In contrast to English words that
      follow grapheme-to-phoneme correspondence rule, the iconic nature of Chinese
      words might predispose them to activate their semantic representations more
      directly from their orthographies. By using the paradigm of repetition blindness
      (RB) that taps into the early level of word processing, we examined whether
      Chinese words activate their semantic representations as directly as pictures do.
      RB refers to the failure to detect the second occurrence of an item when it is
      presented twice in temporal proximity. Previous studies showed RB for
      semantically related pictures, suggesting that pictures activate their semantic
      representations directly from their shapes and thus two semantically related
      pictures are represented as repeated. However, this does not apply to English
      words since no RB was found for English synonyms. In this study, we replicated
      the semantic RB effect for pictures, and further showed the absence of semantic
      RB for Chinese synonyms. Based on our findings, it is suggested that Chinese
      words are processed like English words, which do not activate their semantic
      representations as directly as pictures do.

PMID- 29844333
TI  - Direct observation of pure pentavalent uranium in U2O5 thin films by high
      resolution photoemission spectroscopy.
AB  - Thin films of the elusive intermediate uranium oxide U2O5 have been prepared by
      exposing UO3 precursor multilayers to atomic hydrogen. Electron photoemission
      spectra measured about the uranium 4f core-level doublet contain sharp satellites
      separated by 7.9(1) eV from the 4f main lines, whilst satellites characteristics
      of the U(IV) and U(VI) oxidation states, expected respectively at 6.9(1) and
      9.7(1) eV from the main 4f lines, are absent. This shows that uranium ions in the
      films are in a pure pentavalent oxidation state, in contrast to previous
      investigations of binary oxides claiming that U(V) occurs only as a metastable
      intermediate state coexisting with U(IV) and U(VI) species. The ratio between the
      5f valence band and 4f core-level uranium photoemission intensities decreases by
      about 50% from UO2 to U2O5, which is consistent with the 5f 2 (UO2) and 5f 1
      (U2O5) electronic configurations of the initial state. Our studies conclusively
      establish the stability of uranium pentoxide.

PMID- 29844334
TI  - Effective adaptation to rising flood risk.

PMID- 29844335
TI  - Homodimerisation-independent cleavage of dsRNA by a pestiviral nicking
      endoribonuclease.
AB  - The glycoprotein Erns plays a central role in the biology of the pestivirus
      bovine viral diarrhea virus (BVDV). This soluble endonuclease mediates the escape
      from an interferon (IFN) response in the infected fetus, thereby permitting the
      establishment of persistent infection. Viral single-stranded (ss) and double
      stranded (ds) RNA act as potent IFN inducing signals and we previously showed
      that Erns efficiently cleaves these substrates, thereby inhibiting an IFN
      response that is crucial for successful fetal infection. Considering that a large
      variety of RNases and DNases require dimerisation to cleave double-stranded
      substrates, the activity of Erns against dsRNA was postulated to depend on
      homodimer formation mediated by disulfide bonds involving residue Cys171. Here,
      we show that monomeric Erns is equally able to cleave dsRNA and to inhibit dsRNA
      induced IFN synthesis as the wild-type form. Furthermore, both forms were able to
      degrade RNA within a DNA/RNA- as well as within a methylated RNA/RNA-hybrid, with
      the DNA and the methylated RNA strand being resistant to degradation. These
      results support our model that Erns acts as 'nicking endoribonuclease' degrading
      ssRNA within double-stranded substrates. This efficiently prevents the activation
      of IFN and helps to maintain a state of innate immunotolerance in persistently
      infected animals.

PMID- 29844337
TI  - Quality control of the traditional Chinese medicine Ruyi jinhuang powder based on
      high-throughput sequencing and real-time PCR.
AB  - Traditional Chinese medicine (TCM) has been practiced for thousands of years,
      although concerns about the efficacy, legality, and safety of TCM continue to be
      raised. Chromatographic studies have detected the presence of heavy metals and
      plant toxins within some TCM preparations. However, chromatography is not able to
      identify all of the compounds of TCM, particularly those items that are not
      clearly labeled on the packaging. The present study aimed to establish a
      supplemental method that better assesses the ingredient components of TCM
      preparations.We established an effective approach to screen the biological and
      toxical composition of TCM based on high-throughput sequencing (HTS), as well as
      fast detection and validation of the toxical species by real-time PCR, based on
      ITS2 DNA barcoding. Ruyi jinhuang powder (RHP), a classical herbal prescription
      containing the toxical herb Arisaematis rhizoma, was chosen to test the method.
      This method could determine whether the Arisaematis Rhizoma had been replaced by
      Pinellia pedatisecta in the RHP. The results were validated by real-time PCR. 90%
      compositions of RHP were identified by ITS2 DNA barcoding, suggesting that more
      DNA barcoding markers are needed for TCM identification. The strategy of high
      throughput sequencing has the potential for comprehensive ingredient profiling
      for TCM preparations. Real-time PCR provides a expeditious metehod for monitoring
      the safety and legality of TCM preparations.

PMID- 29844336
TI  - Oxytocin and vasopressin flatten dominance hierarchy and enhance behavioral
      synchrony in part via anterior cingulate cortex.
AB  - The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) influence social
      functions in many mammals. In humans and rhesus macaques, OT delivered
      intranasally can promote prosocial behavior in certain contexts. Yet the precise
      neural mechanisms mediating these behavioral effects remain unclear. Here we show
      that treating a group of male macaque monkeys intranasally with aerosolized OT
      relaxes their spontaneous social interactions with other monkeys. OT reduces
      differences in social behavior between dominant and subordinate monkeys, thereby
      flattening the status hierarchy. OT also increases behavioral synchrony within a
      pair. Intranasal delivery of aerosolized AVP reproduces the effects of OT with
      greater efficacy. Remarkably, all behavioral effects are replicated when OT or
      AVP is injected focally into the anterior cingulate gyrus (ACCg), a brain area
      linked to empathy and other-regarding behavior. ACCg lacks OT receptors but is
      rich in AVP receptors, suggesting exogenous OT may shape social behavior, in
      part, via nonspecific binding. Notably, OT and AVP alter behaviors of both the
      treated monkey and his untreated partner, consistent with enhanced feedback
      through reciprocal social interactions. These findings bear important
      implications for use of OT in both basic research and as a therapy for social
      impairments in neurodevelopmental disorders.

PMID- 29844339
TI  - Author Correction: Rapid Staining of Circulating Tumor Cells in Three-Dimensional
      Microwell Dialysis (3D-MUDialysis) Chip.
AB  - A correction to this article has been published and is linked from the HTML and
      PDF versions of this paper. The error has been fixed in the paper.

PMID- 29844338
TI  - Genome-wide microRNA screening in Nile tilapia reveals pervasive isomiRs'
      transcription, sex-biased arm switching and increasing complexity of expression
      throughout development.
AB  - MicroRNAs (miRNAs) are key regulators of gene expression in multicellular
      organisms. The elucidation of miRNA function and evolution depends on the
      identification and characterization of miRNA repertoire of strategic organisms,
      as the fast-evolving cichlid fishes. Using RNA-seq and comparative genomics we
      carried out an in-depth report of miRNAs in Nile tilapia (Oreochromis niloticus),
      an emergent model organism to investigate evo-devo mechanisms. Five hundred known
      miRNAs and almost one hundred putative novel vertebrate miRNAs have been
      identified, many of which seem to be teleost-specific, cichlid-specific or
      tilapia-specific. Abundant miRNA isoforms (isomiRs) were identified with
      modifications in both 5p and 3p miRNA transcripts. Changes in arm usage (arm
      switching) of nine miRNAs were detected in early development, adult stage and
      even between male and female samples. We found an increasing complexity of miRNA
      expression during ontogenetic development, revealing a remarkable synchronism
      between the rate of new miRNAs recruitment and morphological changes. Overall,
      our results enlarge vertebrate miRNA collection and reveal a notable differential
      ratio of miRNA arms and isoforms influenced by sex and developmental life stage,
      providing a better picture of the evolutionary and spatiotemporal dynamics of
      miRNAs.

PMID- 29844340
TI  - Isospecific adenine DNA methyltransferases show distinct preferences towards DNA
      substrates.
AB  - Here, we report results on systematic analysis of DNA substrate preferences of
      three N6-adenine beta-class DNA methyltransferases that are part of the type II
      restriction-modification systems. The studied enzymes were: M.EcoVIII, M.HindIII
      and M.LlaCI, which although found in phylogenetically distant bacteria (gamma
      proteobacteria and low-GC Gram-positive bacteria), recognize the same palindromic
      specific sequence 5'-AAGCTT-3' and catalyze formation of N6-methyladenine at the
      first A-residue. As expected overall the enzymes share the most analyzed
      features, but they show also some distinct differences in substrate recognition.
      Therefore DNA methylation reactions were carried out not only under standard, but
      also under relaxed conditions using DMSO or glycerol. We found that all of these
      enzymes preferred DNA containing a hemimethylated target site, but differ in
      modification of ssDNA, especially more pronounced for M.EcoVIII under relaxed
      conditions. In these conditions they also have shown varied preferences toward
      secondary sites, which differ by one nucleotide from specific sequence. They
      preferred sequences with substitutions at the 1st (A1 -> G/C) and at the 2nd
      position (A2 -> C), while sites with substitutions at the 3rd position (G3 ->
      A/C) were modified less efficiently. Kinetic parameters of the methylation
      reaction carried out by M.EcoVIII were determined. Methylation efficiency
      (kcat/Km) of secondary sites was 4.5-10 times lower when compared to the
      unmethylated specific sequences, whilst efficiency observed for the
      hemimethylated substrate was almost 4.5 times greater. We also observed a
      distinct effect of analyzed enzymes on unspecific interaction with DNA phosphate
      backbone. We concluded that for all three enzymes the most critical is the
      phosphodiester bond between G3-C4 nucleotides at the center of the target site.

PMID- 29844342
TI  - Stabilization of molten salt materials using metal chlorides for solar thermal
      storage.
AB  - The effect of a variety of metal-chlorides additions on the melting behavior and
      thermal stability of commercially available salts was investigated. Ternary salts
      comprised of KNO3, NaNO2, and NaNO3 were produced with additions of a variety of
      chlorides (KCl, LiCl, CaCl2, ZnCl2, NaCl and MgCl2). Thermogravimetric analysis
      and weight loss experiments showed that the quaternary salt containing a 5 wt%
      addition of LiCl and KCl led to an increase in short term thermal stability
      compared to the ternary control salts. These additions allowed the salts to
      remain stable up to a temperature of 630  degrees C. Long term weight loss
      experiments showed an upper stability increase of 50  degrees C. A 5 wt% LiCl
      addition resulted in a weight loss of only 25% after 30 hours in comparison to a
      61% loss for control ternary salts. Calorimetry showed that LiCl additions allow
      partial melting at 80  degrees C, in comparison to the 142  degrees C of ternary
      salts. This drop in melting point, combined with increased stability, provided a
      molten working range increase of almost 100  degrees C in total, in comparison to
      the control ternary salts. XRD analysis showed the oxidation effect of
      decomposing salts and the additional phase created with LiCl additions to allow
      melting point changes to occur.

PMID- 29844341
TI  - Leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1 activation are
      required for position-dependent regeneration.
AB  - In animal regeneration, control of position-dependent cell proliferation is
      crucial for the complete restoration of patterned appendages in terms of both,
      shape and size. However, detailed mechanisms of this process are largely unknown.
      In this study, we identified leucine/glutamine and v-ATPase/lysosomal
      acidification, via mechanistic target of rapamycin complex 1 (mTORC1) activation,
      as effectors of amputation plane-dependent zebrafish caudal fin regeneration.
      mTORC1 activation, which functions in cell proliferation, was regulated by
      lysosomal acidification possibly via v-ATPase activity at 3 h post amputation
      (hpa). Inhibition of lysosomal acidification resulted in reduced growth factor
      related gene expression and suppression of blastema formation at 24 and 48 hpa,
      respectively. Along the proximal-distal axis, position-dependent lysosomal
      acidification and mTORC1 activation were observed from 3 hpa. We also report that
      Slc7a5 (L-type amino acid transporter), whose gene expression is position
      dependent, is necessary for mTORC1 activation upstream of lysosomal acidification
      during fin regeneration. Furthermore, treatment with leucine and glutamine, for
      both proximal and distal fin stumps, led to an up-regulation in cell
      proliferation via mTORC1 activation, indicating that leucine/glutamine signaling
      possesses the ability to change the position-dependent regeneration. Our findings
      reveal that leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1
      activation are required for position-dependent zebrafish fin regeneration.

PMID- 29844343
TI  - Nonlinear optical components for all-optical probabilistic graphical model.
AB  - The probabilistic graphical models (PGMs) are tools that are used to compute
      probability distributions over large and complex interacting variables. They have
      applications in social networks, speech recognition, artificial intelligence,
      machine learning, and many more areas. Here, we present an all-optical
      implementation of a PGM through the sum-product message passing algorithm (SPMPA)
      governed by a wavelength multiplexing architecture. As a proof-of-concept, we
      demonstrate the use of optics to solve a two node graphical model governed by
      SPMPA and successfully map the message passing algorithm onto photonics
      operations. The essential mathematical functions required for this algorithm,
      including multiplication and division, are implemented using nonlinear optics in
      thin film materials. The multiplication and division are demonstrated through a
      logarithm-summation-exponentiation operation and a pump-probe saturation process,
      respectively. The fundamental bottlenecks for the scalability of the presented
      scheme are discussed as well.

PMID- 29844344
TI  - Optimum Sowing Date and Genotype Testing for Upland Rice Production in Brazil.
AB  - A better understanding of widespread agricultural practices adopted in the region
      of Ribeira Valley, Sao Paulo, Brazil for upland rice (Oryza sativa L.) production
      is needed. The objectives of this study were to determine the optimum sowing date
      and highest yielding genotypes for rice production. Treatments included four
      upland rice genotypes (ANA 5011, AN-Cambara, Moti-Amarelo, and Moti-Branco) and
      four sowing dates (October, November, December, and January) in 2011 and 2012.
      The results of the study showed that genotype ANA 5011 had the earliest maturity,
      while the Moti genotypes had the latest maturity in all sowing dates. The Moti
      genotypes were found to have greater plant height and 1,000-grain weight than the
      other two genotypes. In contrast, the Moti genotypes had fewer panicles m-2,
      fewer total filled and total numbers of spikelets panicle-1, and lower final
      yield. The genotype AN-Cambara had the highest number of tillers, filled and
      total number of spikelets panicle-1, panicle m-2, and the highest yield. Sowing
      in either November or December was found to be the most suitable dates for rice
      cultivation for all genotypes. In conclusion, the AN-Cambara genotype was found
      to have the highest yield potential for the region among all genotypes studied.

PMID- 29844345
TI  - SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and
      differentiation through repression of MYF5 and MYOD function.
AB  - Rhabdomyosarcoma (RMS) is a mesenchymal tumor of soft tissue in children that
      originates from a myogenic differentiation defect. Expression of SNAIL
      transcription factor is elevated in the alveolar subtype of RMS (ARMS),
      characterized by a low myogenic differentiation status and high aggressiveness.
      In RMS patients SNAIL level increases with higher stage. Moreover, SNAIL level
      negatively correlates with MYF5 expression. The differentiation of human ARMS
      cells diminishes SNAIL level. SNAIL silencing in ARMS cells inhibits
      proliferation and induces differentiation in vitro, and thereby completely
      abolishes the growth of human ARMS xenotransplants in vivo. SNAIL silencing
      induces myogenic differentiation by upregulation of myogenic factors and muscle
      specific microRNAs, such as miR-206. SNAIL binds to the MYF5 promoter suppressing
      its expression. SNAIL displaces MYOD from E-box sequences (CANNTG) that are
      associated with genes expressed during differentiation and G/C rich in their
      central dinucleotides. SNAIL silencing allows the re-expression of MYF5 and
      canonical MYOD binding, promoting ARMS cell myogenic differentiation. In
      differentiating ARMS cells SNAIL forms repressive complex with histone
      deacetylates 1 and 2 (HDAC1/2) and regulates their expression. Accordingly, in
      human myoblasts SNAIL silencing induces differentiation by upregulation of
      myogenic factors. Our data clearly point to SNAIL as a key regulator of myogenic
      differentiation and a new promising target for future ARMS therapies.

PMID- 29844346
TI  - Classification of Spatiotemporal Neural Activity Patterns in Brain Imaging Data.
AB  - Various patterns of neural activity are observed in dynamic cortical imaging
      data. Such patterns may reflect how neurons communicate using the underlying
      circuitry to perform appropriate functions; thus it is crucial to investigate the
      spatiotemporal characteristics of the observed neural activity patterns. In
      general, however, neural activities are highly nonlinear and complex, so it is a
      demanding job to analyze them quantitatively or to classify the patterns of
      observed activities in various types of imaging data. Here, we present our
      implementation of a novel method that successfully addresses the above issues for
      precise comparison and classification of neural activity patterns. Based on two
      dimensional representations of the geometric structure and temporal evolution of
      activity patterns, our method successfully classified a number of computer
      generated sample patterns created from combinations of various spatial and
      temporal patterns. In addition, we validated our method with voltage-sensitive
      dye imaging data of Alzheimer's disease (AD) model mice. Our analysis algorithm
      successfully distinguished the activity data of AD mice from that of wild type
      with significantly higher performance than previously suggested methods. Our
      result provides a pragmatic solution for precise analysis of spatiotemporal
      patterns of neural imaging data.

PMID- 29844347
TI  - Porcine Neonatal Pancreatic Cell Clusters Maintain Their Multipotency in Culture
      and After Transplantation.
AB  - Ductal epithelium is primarily detected in porcine neonatal pancreatic cell
      clusters (NPCCs) bearing grafts, suggesting that transplants might exhibit
      progenitor-like phenotypes. Here we found that soon after NPCC isolation,
      PDX1+/insulin- and SOX9+ pancreatic progenitor-like cells dramatically increased
      while dual-hormonal progenitor-like cells were routinely observed in NPCC
      culture. After transplantation (Tx), insulin+ cells increased and PDX1+ and SOX9+
      cells gradually decreased in both non-diabetic (NDM) and streptozotocin-induced
      diabetic (DM) grafts over 2 months. Strikingly, a significantly higher percentage
      of insulin+ cells were detected in 9-day and 16-day, but not in 23-day, 30-day
      and 60-day grafts implying that hyperglycemia could only facilitate NPCC-derived
      beta cells early post-Tx. A higher percentage of NPCC-derived beta cells in early
      DM grafts was determined via an enhanced neogenic differentiation based on the
      detection of insulin+ cells budding out from PDX1+/SOX9+ epithelium.
      Interestingly, a drop in SOX9+ progenitor-like cells was detected 16 days post-Tx
      in DM grafts whilst PDX1+ cells do not show a significant difference until 60
      days post-Tx between DM and NDM grafts, demonstrating that distinct progenitor
      like populations fuel new beta cells post-Tx. In conclusion, PDX1+/SOX9+ cells
      could be quickly activated after NPCC isolation, maintain their multipotency in
      culture and differentiate into new beta cell post-Tx.

PMID- 29844348
TI  - HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation
      via paracrine effect.
AB  - Tumor repopulation during therapy is an important cause of treatment failure.
      Strategies to overcome repopulation are arising in parallel with advances in the
      comprehension of underlying biological mechanisms. Here, we reveal a new
      mechanism by which high mobility group box 1 (HMGB1) released by dying cells
      during radiotherapy or chemotherapy could stimulate living tumor cell
      proliferationInhibition or genetic ablation of HMGB1 suppressed tumor cell
      proliferation. This effect was due to binding of HMGB1with the member receptor
      for advanced glycation end-products (RAGE), which activated downstream ERK and
      p38 signaling pathway and promoted cell proliferation. Furthermore, higher HMGB1
      expression in tumor tissue correlated with poor overall survival and higher HMGB1
      concentration was detected in serum of patients who accepted radiotherapy.
      Collectively, the results from this study suggested that interaction between dead
      cells and surviving cells might influence the fate of tumor. HMGB1 could be a
      novel tumor promoter with therapeutic and prognostic relevance in cancers.

PMID- 29844349
TI  - The bioeroding sponge Cliona orientalis will not tolerate future projected ocean
      warming.
AB  - Coral reefs face many stressors associated with global climate change, including
      increasing sea surface temperature and ocean acidification. Excavating sponges,
      such as Cliona spp., are expected to break down reef substrata more quickly as
      seawater becomes more acidic. However, increased bioerosion requires that Cliona
      spp. maintain physiological performance and health under continuing ocean
      warming. In this study, we exposed C. orientalis to temperature increments
      increasing from 23 to 32  degrees C. At 32  degrees C, or 3  degrees C above the
      maximum monthly mean (MMM) temperature, sponges bleached and the photosynthetic
      capacity of Symbiodinium was compromised, consistent with sympatric corals.
      Cliona orientalis demonstrated little capacity to recover from thermal stress,
      remaining bleached with reduced Symbiodinium density and energy reserves after
      one month at reduced temperature. In comparison, C. orientalis was not observed
      to bleach during the 2017 coral bleaching event on the Great Barrier Reef, when
      temperatures did not reach the 32  degrees C threshold. While C. orientalis can
      withstand current temperature extremes (<3  degrees C above MMM) under laboratory
      and natural conditions, this species would not survive ocean temperatures
      projected for 2100 without acclimatisation or adaptation (>=3  degrees C above
      MMM). Hence, as ocean temperatures increase above local thermal thresholds, C.
      orientalis will have a negligible impact on reef erosion.

PMID- 29844351
TI  - An orthogonal system for heterologous expression of actinobacterial lasso
      peptides in Streptomyces hosts.
AB  - Lasso peptides are ribosomally synthesized and post-translationally modified
      peptides produced by bacteria. They are characterized by an unusual lariat-knot
      structure. Targeted genome scanning revealed a wide diversity of lasso peptides
      encoded in actinobacterial genomes, but cloning and heterologous expression of
      these clusters turned out to be problematic. To circumvent this, we developed an
      orthogonal expression system for heterologous production of actinobacterial lasso
      peptides in Streptomyces hosts based on a newly-identified regulatory circuit
      from Actinoalloteichus fjordicus. Six lasso peptide gene clusters, mainly
      originating from marine Actinobacteria, were chosen for proof-of-concept studies.
      By varying the Streptomyces expression hosts and a small set of culture
      conditions, three new lasso peptides were successfully produced and characterized
      by tandem MS. The newly developed expression system thus sets the stage to
      uncover and bioengineer the chemo-diversity of actinobacterial lasso peptides.
      Moreover, our data provide some considerations for future bioprospecting efforts
      for such peptides.

PMID- 29844350
TI  - Repurposing auranofin as an intestinal decolonizing agent for vancomycin
      resistant enterococci.
AB  - Multidrug-resistant enterococcal pathogens, especially vancomycin-resistant
      enterococci (VRE), are among the pathogens that require new antibiotic
      innovation. The colonization of the gut represents a major pathway by which VRE
      can cause infection and spread to other patients. In the current study, auranofin
      (FDA-approved rheumatoid arthritis drug) is evaluated for its potential use as a
      decolonizing agent for VRE. Auranofin was found to exert potent antimicrobial
      activity against a wide range of enterococcal clinical isolates with a minimum
      inhibitory concentration of 1 MUg/mL. No resistant mutants could be developed
      against auranofin over the course of 14 passages. Auranofin was also found to
      exert potent anti-biofilm activity against VRE. Auranofin was superior to
      linezolid, the drug of choice for VRE infection treatment, in the in vivo mouse
      model. Auranofin significantly reduced the VRE burden in feces, cecum, and ileum
      contents after 8 days of treatment. Accordingly, this study provides valuable
      evidence that auranofin has significant promise as a novel gastrointestinal
      decolonizing agent for VRE.

PMID- 29844352
TI  - A physical model of cell metabolism.
AB  - Cell metabolism is characterized by three fundamental energy demands: to sustain
      cell maintenance, to trigger aerobic fermentation and to achieve maximum
      metabolic rate. The transition to aerobic fermentation and the maximum metabolic
      rate are currently understood based on enzymatic cost constraints. Yet, we are
      lacking a theory explaining the maintenance energy demand. Here we report a
      physical model of cell metabolism that explains the origin of these three energy
      scales. Our key hypothesis is that the maintenance energy demand is rooted on the
      energy expended by molecular motors to fluidize the cytoplasm and counteract
      molecular crowding. Using this model and independent parameter estimates we make
      predictions for the three energy scales that are in quantitative agreement with
      experimental values. The model also recapitulates the dependencies of cell growth
      with extracellular osmolarity and temperature. This theory brings together
      biophysics and cell biology in a tractable model that can be applied to
      understand key principles of cell metabolism.

PMID- 29844353
TI  - Metabolic patterns in insulin-sensitive male hypogonadism.
AB  - Male hypogonadism is a disorder characterised by low levels of the hormone
      testosterone. At beginning subjects with low levels of testosterone do not show
      insulin resistance (insulin-sensitive patients), which develops over time
      (insulin-resistance patients). To analyse the metabolic alterations mainly
      related to decreased testosterone, we performed metabolomics investigations on
      the plasma of males with hypogonadism who showed normal insulin levels. Plasma
      from patients with low testosterone (<8 nmol/l) and homeostatic model assessment
      for insulin-resistance-index (HOMAi) < 2.5, as well as matched controls, was
      analysed by UHPLC and mass spectrometry. Then metabolites were then subjected to
      multivariate statistical analysis and grouped by metabolic pathways. Glycolysis
      was not altered, as expected for the presence of insulin activity, but imbalances
      in several other pathways were found, such as the pentose phosphate pathway
      (PPP), glycerol shuttle, malate shuttle, Krebs cycle (TCA) and lipid metabolism.
      The PPP was significantly upregulated. Moreover, while the first steps of the
      Krebs cycle were downregulated, 2-oxoglutarate was replenished via
      glutaminolysis. Since glutaminolysis leads to an activation of the malate
      aspartate cycle, greater amounts of NADH and ATP with respect to the control were
      recorded. The activation of the glycerol shuttle was also recorded, with
      consequent lower triglyceride production and downregulation of beta-oxidation.
      This explained the moderately increased dyslipidaemia, as well as the mild
      increase in body mass index (BMI) observed in insulin-sensitive hypogonadism.
      Finally, a significant decrease in carnosine was recorded, explaining the muscle
      weakness commonly observed.

PMID- 29844354
TI  - Sub-threshold signal encoding in coupled FitzHugh-Nagumo neurons.
AB  - Despite intensive research, the mechanisms underlying the neural code remain
      poorly understood. Recent work has focused on the response of a single neuron to
      a weak, sub-threshold periodic signal. By simulating the stochastic FitzHugh
      Nagumo (FHN) model and then using a symbolic method to analyze the firing
      activity, preferred and infrequent spike patterns (defined by the relative timing
      of the spikes) were detected, whose probabilities encode information about the
      signal. As not individual neurons but neuronal populations are responsible for
      sensory coding and information transfer, a relevant question is how a second
      neuron, which does not perceive the signal, affects the detection and the
      encoding of the signal, done by the first neuron. Through simulations of two
      stochastic FHN neurons we show that the encoding of a sub-threshold signal in
      symbolic spike patterns is a plausible mechanism. The neuron that perceives the
      signal fires a spike train that, despite having an almost random temporal
      structure, has preferred and infrequent patterns which carry information about
      the signal. Our findings could be relevant for sensory systems composed by two
      noisy neurons, when only one detects a weak external input.

PMID- 29844355
TI  - Psychiatric risk gene Cacna1c determines mitochondrial resilience against
      oxidative stress in neurons.

PMID- 29844356
TI  - Niche-induced extramedullary hematopoiesis in the spleen is regulated by the
      transcription factor Tlx1.
AB  - Extramedullary hematopoiesis (EMH) in postnatal life is a pathological process in
      which the differentiation of hematopoietic stem/progenitor cells (HSPCs) occurs
      outside the bone marrow (BM) to respond to hematopoietic emergencies. The spleen
      is a major site for EMH; however, the cellular and molecular nature of the
      stromal cell components supporting HSPC maintenance, the niche for EMH in the
      spleen remain poorly understood compared to the growing understanding of the BM
      niche at the steady-state as well as in emergency hematopoiesis. In the present
      study, we demonstrate that mesenchymal progenitor-like cells expressing Tlx1, an
      essential transcription factor for spleen organogenesis, and selectively
      localized in the perifollicular region of the red pulp of the spleen, are a major
      source of HSPC niche factors. Consistently, overexpression of Tlx1 in situ
      induces EMH, which is associated with mobilization of HSPC into the circulation
      and their recruitment into the spleen where they proliferate and differentiate.
      The alterations in the splenic microenvironment induced by Tlx1 overexpression in
      situ phenocopy lipopolysaccharide (LPS)-induced EMH, and the conditional loss of
      Tlx1 abolished LPS-induced splenic EMH. These findings indicate that activation
      of Tlx1 expression in the postnatal splenic mesenchymal cells is critical for the
      development of splenic EMH.

PMID- 29844357
TI  - Transient modes of zeolite surface growth from 3D gel-like islands to 2D single
      layers.
AB  - Zeolite crystallization occurs by multifaceted processes involving molecule
      attachment and nonclassical pathways governed by the addition of amorphous
      precursors. Here, we use scanning probe microscopy to monitor zeolite LTA
      crystallization in situ with a spatiotemporal resolution that captures dynamic
      processes in real time. We report a distinctive pathway involving the formation
      of gel-like islands from supersaturated solutions comprised of (alumino)silicate
      molecules. Three-dimensional assembly and evolution of these islands constitutes
      a unique mode of growth that differs from classical theories. Time-resolved
      imaging also reveals that growth can occur by (nearly) oriented attachment. At
      later stages of crystallization, a progressive transition to lower
      supersaturation shifts growth to a layered mechanism involving two-dimensional
      nucleation and spreading of layers. Here, we show that LTA crystallization occurs
      by multiple pathways, thereby reconciling putative hypotheses of growth
      mechanisms while also highlighting new modes of nonclassical crystallization that
      may prove relevant to other zeolites and related materials.

PMID- 29844358
TI  - Chemically activating MoS2 via spontaneous atomic palladium interfacial doping
      towards efficient hydrogen evolution.
AB  - Lacking strategies to simultaneously address the intrinsic activity, site
      density, electrical transport, and stability problems of chalcogels is
      restricting their application in catalytic hydrogen production. Herein, we
      resolve these challenges concurrently through chemically activating the
      molybdenum disulfide (MoS2) surface basal plane by doping with a low content of
      atomic palladium using a spontaneous interfacial redox technique. Palladium
      substitution occurs at the molybdenum site, simultaneously introducing sulfur
      vacancy and converting the 2H into the stabilized 1T structure. Theoretical
      calculations demonstrate the sulfur atoms next to the palladium sites exhibit low
      hydrogen adsorption energy at -0.02 eV. The final MoS2 doped with only 1wt% of
      palladium demonstrates exchange current density of 805 MUA cm-2 and 78 mV
      overpotential at 10 mA cm-2, accompanied by a good stability. The combined
      advantages of our surface activating technique open the possibility of
      manipulating the catalytic performance of MoS2 to rival platinum.

PMID- 29844359
TI  - Various stress stimuli rewire the profile of liver secretome in a p53-dependent
      manner.
AB  - Liver is an important secretory organ that consistently manages various insults
      in order to retain whole-body homeostasis. Importantly, it was suggested that the
      tumor-suppressor p53 plays a role in a variety of liver physiological processes
      and thus it is being regarded as a systemic homeostasis regulator. Using high
      throughput mass spectrometric analysis, we identified various p53-dependent liver
      secretome profiles. This allowed a global view on the role of p53 in maintaining
      the harmony of liver and whole-body homeostasis. We found that p53 altered the
      liver secretome differently under various conditions. Under physiological
      conditions, p53 controls factors that are related mainly to lipid metabolism and
      injury response. Upon exposure to various types of cancer therapy agents, the
      hepatic p53 is activated and induces the secretion of proteins related to
      additional pathways, such as hemostasis, immune response, and cell adhesion.
      Interestingly, we identified a possible relationship between p53-dependent liver
      functions and lung tumors. The latter modify differently liver secretome profile
      toward the secretion of proteins mainly related to cell migration and immune
      response. The notion that p53 may rewire the liver secretome profile suggests a
      new non-cell autonomous role of p53 that affect different liver functions and
      whole organism homeostasis.

PMID- 29844360
TI  - Amblyopia, Strabismus and Refractive Errors in Congenital Ptosis: a systematic
      review and meta-analysis.
AB  - Congenital ptosis may be associated with abnormalities of visual development and
      function, including amblyopia, strabismus and refractive errors. However, the
      prevalence estimates of these abnormalities vary widely. We performed a
      systematic review and meta-analysis to estimate the prevalence of amblyopia,
      strabismus and refractive errors in congenital ptosis. Cochrane, Pubmed, Medline,
      Embase, and Web of Science were searched by July 2017. We used random/fixed
      effects models based on a proportion approach to estimate the prevalence.
      Heterogeneity would be considered signifcant if the p values less than 0.1 and/or
      I2 greater than 50%. Subgroup analyses, meta-regression analyses and sensitivity
      analyses were utilized to explore the potential sources of it. A total of 24
      studies selected from 3,633 references were included. The highest prevalence was
      revealed for myopia with 30.2% (95%CI 3.0-69.8%), followed by 22.7% (95%CI 18.5
      27.8%) for amblyopia, 22.2% (95%CI 7.8-63.1%) for astigmatism, 19.6% (95%CI 16.5
      23.2%) for strabismus, 17.3% (95% CI 13.1-22.9%) for anisometropia and 4.0% for
      hyperopia (95%CI 1.8-7.1%). Significant heterogeneity was identified across most
      estimates. Our findings suggest that amblyopia, strabismus and refractive errors
      in congenital ptosis are present in much higher percentage. This study highlights
      the importance of early diagnosis and timely treatment of patients with
      congenital ptosis.

PMID- 29844361
TI  - Dimethyl fumarate induces a persistent change in the composition of the innate
      and adaptive immune system in multiple sclerosis patients.
AB  - The effects of dimethyl fumarate (DMF) on the immune system in multiple sclerosis
      (MS) are not completely elucidated. In this study, an extensive immunophenotypic
      analysis of innate and adaptive immune cells of DMF-treated MS patients was
      performed. Peripheral blood immune cell phenotypes were determined using flow
      cytometry in a follow-up study of 12 MS patients before, after 3 and 12 months of
      DMF treatment and a cross-sectional study of 25 untreated and 64 DMF-treated MS
      patients. Direct effects of DMF on B cells were analyzed in vitro. After 12
      months of DMF treatment, percentages of monocytes, natural killer cells, naive T
      and B cells and transitional B cells increased. Percentages of (effector) memory
      T cells, (non) class-switched memory B cells and double negative B cells
      decreased together with CD4+ T cells expressing interferon-gamma (IFN-gamma),
      granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-17 (IL
      17). DMF treatment was fully effective as of 6 months and directly induced
      apoptosis and decreased expression of costimulatory CD40, antigen presentation
      molecule MHCII and B cell activating factor receptor (BAFFR) on B cells. DMF
      induced a persistent change of the immune system of MS patients, directly induced
      apoptosis and reduced expression of functional markers on B cells.

PMID- 29844362
TI  - Basal interferon signaling and therapeutic use of interferons in controlling
      rotavirus infection in human intestinal cells and organoids.
AB  - Rotavirus (RV) primarily infects enterocytes and results in severe diarrhea,
      particularly in children. It is known that the host immune responses determine
      the outcome of viral infections. Following infections, interferons (IFNs) are
      produced as the first and the main anti-viral cytokines to combat the virus. Here
      we showed that RV predominantly induced type III IFNs (IFN-lambda1), and to a
      less extent, type I IFNs (IFN-alpha and IFN-beta) in human intestinal cells.
      However, it did not produce detectable IFN proteins and thus, was not sufficient
      to inhibit RV replication. In contrast, we revealed the essential roles of the
      basal IFN signaling in limiting RV replication by silencing STAT1, STAT2 and IRF9
      genes. In addition, exogenous IFN treatment demonstrated that RV replication was
      able to be inhibited by all types of IFNs, both in human intestinal Caco2 cell
      line and in primary intestinal organoids. In these models, IFNs significantly
      upregulated a panel of well-known anti-viral IFN-stimulated genes (ISGs).
      Importantly, inhibition of the JAK-STAT cascade abrogated ISG induction and the
      anti-RV effects of IFNs. Thus, our study shall contribute to better understanding
      of the complex RV-host interactions and provide rationale for therapeutic
      development of IFN-based treatment against RV infection.

PMID- 29844363
TI  - In situ redox reactions facilitate the assembly of a mixed-valence metal-organic
      nanocapsule.
AB  - C-alkylpyrogallol[4]arenes (PgCs) have been studied for their ability to form
      metal-organic nanocapsules (MONCs) through coordination to appropriate metal
      ions. Here we present the synthesis and characterization of an MnII/MnIII-seamed
      MONC in addition to its electrochemical and magnetic behavior. This MONC
      assembles from 24 manganese ions and 6 PgCs, while an additional metal ion is
      located on the capsule interior, anchored through the introduction of bridging
      nitrite ions. The latter originate from an in situ redox reaction that occurs
      during the self-assembly process, thus representing a new route to otherwise
      unobtainable nanocapsules.

PMID- 29844365
TI  - Evapotranspiration and favorable growing degree-days are key to tree height
      growth and ecosystem functioning: Meta-analyses of Pacific Northwest historical
      data.
AB  - While temperature and precipitation comprise important ecological filtering for
      native ranges of forest trees and are predisposing factors underlying forest
      ecosystem dynamics, the extent and severity of drought raises reasonable concerns
      for carbon storage and species diversity. Based on historical data from common
      garden experiments across the Pacific Northwest region, we developed non-linear
      niche models for height-growth trajectories of conifer trees at the sapling stage
      using annual or seasonal climatic variables. The correlations between virtual
      tree height for each locality and ecosystem functions were respectively assessed.
      Best-fitted models were composed of two distinct components: evapotranspiration
      and the degree-days disparity for temperature regimes between 5  degrees C and 18
      degrees C (effective temperature sum and growth temperature, respectively). Tree
      height prediction for adaptive generalists (e.g., Pinus monticola, Thuja plicata)
      had smaller residuals than for specialists (e.g., Pinus contorta, Pseudotsuga
      menziesii), albeit a potential confounding factor - tree age. Discernably, there
      were linearly positive patterns between tree height growth and ecosystem
      functions (productivity, biomass and species diversity). Additionally, there was
      a minor effect of tree diversity on height growth in coniferous forests. This
      study uncovers the implication of key ecological filtering and increases our
      integrated understanding of how environmental cues affect tree stand growth,
      species dominance and ecosystem functions.

PMID- 29844364
TI  - STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the
      perinuclear actin cap.
AB  - The perinuclear actin cap is an important cytoskeletal structure that regulates
      nuclear morphology and re-orientation during front-rear polarisation. The
      mechanisms regulating the actin cap are currently poorly understood. Here, we
      demonstrate that STEF/TIAM2, a Rac1 selective guanine nucleotide exchange factor,
      localises at the nuclear envelope, co-localising with the key perinuclear
      proteins Nesprin-2G and Non-muscle myosin IIB (NMMIIB), where it regulates
      perinuclear Rac1 activity. We show that STEF depletion reduces apical perinuclear
      actin cables (a phenotype rescued by targeting active Rac1 to the nuclear
      envelope), increases nuclear height and impairs nuclear re-orientation. STEF down
      regulation also reduces perinuclear pMLC and decreases myosin-generated tension
      at the nuclear envelope, suggesting that STEF-mediated Rac1 activity regulates
      NMMIIB activity to promote stabilisation of the perinuclear actin cap. Finally,
      STEF depletion decreases nuclear stiffness and reduces expression of TAZ
      regulated genes, indicating an alteration in mechanosensing pathways as a
      consequence of disruption of the actin cap.

PMID- 29844366
TI  - E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome
      and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based
      treatments.
AB  - The main goal of this study was to find out strategies of clinical relevance to
      classify patients with a pancreatic ductal adenocarcinoma (PDAC) for
      individualized treatments. In the present study a set of 55 patient-derived
      xenografts (PDX) were obtained and their transcriptome were analyzed by using an
      Affymetrix approach. A supervised bioinformatics-based analysis let us to
      classify these PDX in two main groups named E2F-highly dependent and E2F-lowly
      dependent. Afterwards their characterization by using a Kaplan-Meier analysis
      demonstrated that E2F high patients survived significantly less than E2F low
      patients (9.5 months vs. 16.8 months; p = 0.0066). Then we tried to establish if
      E2F transcriptional target levels were associated to the response to cytotoxic
      treatments by comparing the IC50 values of E2F high and E2F low cells after
      gemcitabine, 5-fluorouracil, oxaliplatin, docetaxel or irinotecan treatment, and
      no association was found. Then we identified an E2F inhibitor compound, named
      ly101-4B, and we observed that E2F-higly dependent cells were more sensitive to
      its treatment (IC50 of 19.4 +/- 1.8 uM vs. 44.1 +/- 4.4 uM; p = 0.0061). In
      conclusion, in this work we describe an E2F target expression-based
      classification that could be predictive for patient outcome, but more important,
      for the sensitivity of tumors to the E2F inhibitors as a treatment. Finally, we
      can assume that phenotypic characterization, essentially by an RNA expression
      analysis of the PDAC, can help to predict their clinical outcome and their
      response to some treatments when are rationally selected.

PMID- 29844367
TI  - A cluster of nontuberculous mycobacterial endophthalmitis (NTME) cases after
      cataract surgery: clinical features and treatment outcomes.
AB  - PURPOSE: To report the clinical features and treatment outcomes in a cluster of
      patients with endophthalmitis after cataract surgery caused by nontuberculous
      mycobacterium. PATIENTS AND METHODS: Retrospective chart review and
      noncomparative, consecutive case series. Nine consecutive cases of
      endophthalmitis, after cataract surgery in a local clinic, were referred to our
      hospital. The treatment outcomes and analysis of risk factors for infection are
      reported. RESULTS: The major symptoms at presentation were pain, redness, and
      decreased vision. Best-corrected visual acuity at presentation ranged from hand
      motion in two cases (22%), counting fingers at 30 cm in three cases (33%), 20/100
      in two cases (20%), 20/63 in one case (11%), to 20/50 in one (11%) case. The mean
      duration between cataract surgery to presentation at our hospital was 16.7 days.
      Prompt intravitreal injections (IVI) of amikacin (0.4 mg/0.1 mL) and vancomycin
      (1 mg/0.1 mL), with topical moxifloxacin were administered initially. Pars plana
      vitrectomy with amikacin (10 mg/L) and vancomycin (20 mg/L) intravitreal
      irrigation, and intraocular lens removal were performed for all patients.
      Systemic antibiotics including amikacin and tigecycline were prescribed for 10
      days, and clarithromycin was prescribed for at least 3 months. In all the nine
      cases, the culture results from either aqueous tapping or vitrectomy sample were
      positive for nontuberculous Mycobacterium: Mycobacterium abscessus/chelonae,
      which was compatible with iatrogenic clustered infection. At the last follow-up,
      three cases (33.3%) had best-corrected visual acuity of counting fingers at 30
      cm, while the other six cases had no light perception. Two cases (22%) were
      enucleated and one case (11%) had phthisis bulbi. CONCLUSION: Nontuberculous
      mycobacterium endophthalmitis (NTME) often induces chronic recurrent or
      persistent intraocular inflammation. Very poor outcomes despite aggressive
      antibiotic treatment and repeated surgical interventions are suggestive of the
      virulent nature of the organisms. Autoclave sterilization and perioperative
      disinfection may help in reducing iatrogenic clustered infection.

PMID- 29844368
TI  - Non-inverted pedicle internal limiting membrane transposition for large macular
      holes.
AB  - PURPOSE: The purpose of this study is to investigate the effectiveness of a new
      surgical technique of non-inverted pedicle internal limiting membrane (ILM)
      transposition for the treatment of eyes with large macular hole. METHODS: This is
      a retrospective, consecutive, interventional case series. Twelve eyes of 12
      consecutive patients who underwent vitrectomy for the treatment of a large
      macular hole (MH size > 400 um) were treated. ILM was peeled and left with a
      pedicle attached to the superior temporal retina. The macular hole was covered by
      transposition of the pedicle ILM in a non-inverted way. Preoperative and
      postoperative best-corrected visual acuity (BCVA), SD-OCT image, macular
      sensitivity by microperimetry, and multifocal electroretinogram (mERG) response
      were evaluated. All of the patients were followed for more than 3 months.
      RESULTS: Postoperative OCT examination confirmed 11 of 12 macular hole closed
      (91.7%). Six macular hole filled with silicone oil closed as early as the next
      day. The postoperative BCVA significantly increased compared with preoperative
      BCVA (P = 0.002). The improvement of macular sensitivity within 2 degrees  and 8
      degrees  circle was also statistical significant (P = 0.018 and P = 0.017,
      respectively). Fixation stability, shown as the percentage of fixation point
      within the 2 degrees  circle and 4 degrees  circle, was remarkably improved (P =
      0.017 and P = 0.018, respectively). The R1/R2 and R1/R4 ring ratios also
      increased significantly as compared with that of baseline. CONCLUSION: These
      findings indicate that the non-inverted pedicle ILM transposition results in a
      high incidence of anatomic closure with good visual outcome for the treatment of
      large macular hole.

PMID- 29844369
TI  - Composite binocular perception from dichoptic stimulus arrays with similar
      ensemble information.
AB  - We view the world through laterally displaced eyes that generate two streams of
      image signals differing slightly in their perspectives of the visual scene. The
      brain derives three-dimensional structures from these two image streams by
      establishing binocular matches and computing image disparities between the two
      eyes' views. Since the binocular matching problem can have multiple, alternative
      solutions, vision relies on several strategies to determine the most probable
      matches. The current study investigated whether the visual system might utilize
      regularities among neighbouring features (feature ensembles) when confronting
      this problem. We hypothesized that binocular perception with unlikely, anomalous
      ensembles would indicate unsuccessful binocular matches. We made dichoptic
      stimulus arrays of coloured circles and manipulated the colour similarity of
      stimulus items to produce probable or unusual ensembles when superimposed. Using
      binocular rivalry as a proxy index, we found that composite perception of
      dichoptic arrays was more stable when the stimulus items shared similar colours,
      and that unusual ensembles induced binocular rivalry. Our results suggest that
      binocular ensembles can be utilized to detect unsuccessful binocular matches,
      thus uncovering a potentially useful supplemental strategy for identifying
      binocular matches when viewing potentially confusing visual scenes containing
      redundant visual features.

PMID- 29844370
TI  - mTOR coordinates transcriptional programs and mitochondrial metabolism of
      activated Treg subsets to protect tissue homeostasis.
AB  - Regulatory T (Treg) cells derived from the thymus (tTreg) and periphery (pTreg)
      have central and distinct functions in immunosuppression, but mechanisms for the
      generation and activation of Treg subsets in vivo are unclear. Here, we show that
      mechanistic target of rapamycin (mTOR) unexpectedly supports the homeostasis and
      functional activation of tTreg and pTreg cells. mTOR signaling is crucial for
      programming activated Treg-cell function to protect immune tolerance and tissue
      homeostasis. Treg-specific deletion of mTOR drives spontaneous effector T-cell
      activation and inflammation in barrier tissues and is associated with reduction
      in both thymic-derived effector Treg (eTreg) and pTreg cells. Mechanistically,
      mTOR functions downstream of antigenic signals to drive IRF4 expression and
      mitochondrial metabolism, and accordingly, deletion of mitochondrial
      transcription factor A (Tfam) severely impairs Treg-cell suppressive function and
      eTreg-cell generation. Collectively, our results show that mTOR coordinates
      transcriptional and metabolic programs in activated Treg subsets to mediate
      tissue homeostasis.

PMID- 29844371
TI  - Intravital imaging by simultaneous label-free autofluorescence-multiharmonic
      microscopy.
AB  - Intravital microscopy (IVM) emerged and matured as a powerful tool for
      elucidating pathways in biological processes. Although label-free multiphoton IVM
      is attractive for its non-perturbative nature, its wide application has been
      hindered, mostly due to the limited contrast of each imaging modality and the
      challenge to integrate them. Here we introduce simultaneous label-free
      autofluorescence-multiharmonic (SLAM) microscopy, a single-excitation source
      nonlinear imaging platform that uses a custom-designed excitation window at 1110
      nm and shaped ultrafast pulses at 10 MHz to enable fast (2-orders-of-magnitude
      improvement), simultaneous, and efficient acquisition of autofluorescence (FAD
      and NADH) and second/third harmonic generation from a wide array of cellular and
      extracellular components (e.g., tumor cells, immune cells, vesicles, and vessels)
      in living tissue using only 14 mW for extended time-lapse investigations. Our
      work demonstrates the versatility and efficiency of SLAM microscopy for tracking
      cellular events in vivo, and is a major enabling advance in label-free IVM.

PMID- 29844372
TI  - All-optical control of long-lived nuclear spins in rare-earth doped
      nanoparticles.
AB  - Nanoscale systems that coherently couple to light and possess spins offer key
      capabilities for quantum technologies. However, an outstanding challenge is to
      preserve properties, and especially optical and spin coherence lifetimes, at the
      nanoscale. Here, we report optically controlled nuclear spins with long coherence
      lifetimes (T2) in rare-earth-doped nanoparticles. We detect spins echoes and
      measure a spin coherence lifetime of 2.9 +/- 0.3 ms at 5 K under an external
      magnetic field of 9 mT, a T2 value comparable to those obtained in bulk rare
      earth crystals. Moreover, we achieve spin T2 extension using all-optical spin
      dynamical decoupling and observe high fidelity between excitation and echo
      phases. Rare-earth-doped nanoparticles are thus the only nano-material in which
      optically controlled spins with millisecond coherence lifetimes have been
      reported. These results open the way to providing quantum light-atom-spin
      interfaces with long storage time within hybrid architectures.

PMID- 29844374
TI  - Macrophage inducible nitric oxide synthase promotes the initiation of lung
      squamous cell carcinoma by maintaining circulated inflammation.

PMID- 29844373
TI  - Habituation of phase-locked local field potentials and gamma-band oscillations
      recorded from the human insula.
AB  - Salient nociceptive and non-nociceptive stimuli elicit low-frequency local field
      potentials (LFPs) in the human insula. Nociceptive stimuli also elicit insular
      gamma-band oscillations (GBOs), possibly preferential for thermonociception,
      which have been suggested to reflect the intensity of perceived pain. To shed
      light on the functional significance of these two responses, we investigated
      whether they would be modulated by stimulation intensity and temporal expectation
      - two factors contributing to stimulus saliency. Insular activity was recorded
      from 8 depth electrodes (41 contacts) implanted in the left insula of 6 patients
      investigated for epilepsy. Thermonociceptive, vibrotactile, and auditory stimuli
      were delivered using two intensities. To investigate the effects of temporal
      expectation, the stimuli were delivered in trains of three identical stimuli (S1
      S2-S3) separated by a constant 1-s interval. Stimulation intensity affected
      intensity of perception, the magnitude of low-frequency LFPs, and the magnitude
      of nociceptive GBOs. Stimulus repetition did not affect perception. In contrast,
      both low-frequency LFPs and nociceptive GBOs showed a marked habituation of the
      responses to S2 and S3 as compared to S1 and, hence, a dissociation with
      intensity of perception. Most importantly, although insular nociceptive GBOs
      appear to be preferential for thermonociception, they cannot be considered as a
      correlate of perceived pain.

PMID- 29844375
TI  - Induction of ganglioside synthesis in Drosophila brain accelerates assembly of
      amyloid beta protein.
AB  - The assembly and deposition of amyloid beta protein (Abeta) is a fundamental
      event during the early stages of Alzheimer's disease (AD) and cerebral amyloid
      angiopathy. A growing body of evidence indicates that gangliosides form a
      pathological platform for the generation of ganglioside-bound Abeta, which
      facilitates the assembly of soluble Abetas; however, the molecular mechanisms
      underlying the binding of Abeta to gangliosides in the brain remain unclear due
      to the lack of an in vivo system that may address this issue. In insects,
      including the fruit fly Drosophila melanogaster, gangliosides are not
      intrinsically present at a detectable level. We herein demonstrate that
      ganglioside expression is inducible in Drosophila via the expression of
      transgenes of ganglioside synthesis enzymes and the feeding of exogenous sialic
      acid, and also that the induction of ganglioside synthesis significantly
      accelerates Abeta assembly in vivo. Our results support the hypothesis that
      gangliosides are responsible for Abeta assembly in vivo and also provide an
      opportunity to develop a valuable model for basic research as well as a
      therapeutic strategy for AD.

PMID- 29844377
TI  - Terahertz wave modulation enhanced by laser processed PVA film on Si substrate.
AB  - An optically pumped ultrasensitive broadband terahertz (THz) wave modulator based
      on polyvinyl alcohol (PVA) film on Si wafer was demonstrated in this work. The
      THz time domain spectroscopy experiments confirm that the PVA/Si can drastically
      enhance the photo-induced THz wave modulation on the Si surface, especially when
      the PVA film is heated by a high-power laser. A modulation depth of 72% can be
      achieved only under 0.55 W/cm2 modulated laser power, which is superior
      significantly to the bare Si. The numerical simulations indicate that the laser
      processed PVA (LP-PVA) film increases the photo-generated carrier concentration
      on the Si surface in two orders of magnitude higher than that of bare Si.
      Moreover, the modulation mechanism and the dynamic process of laser heating on
      the PVA/Si have been discussed. This highly efficient THz modulation mechanism
      and its simple fabrication method have great application potentials in THz
      modulators.

PMID- 29844376
TI  - Uranium(III)-carbon multiple bonding supported by arene delta-bonding in mixed
      valence hexauranium nanometre-scale rings.
AB  - Despite the fact that non-aqueous uranium chemistry is over 60 years old, most
      polarised-covalent uranium-element multiple bonds involve formal uranium
      oxidation states IV, V, and VI. The paucity of uranium(III) congeners is because,
      in common with metal-ligand multiple bonding generally, such linkages involve
      strongly donating, charge-loaded ligands that bind best to electron-poor metals
      and inherently promote disproportionation of uranium(III). Here, we report the
      synthesis of hexauranium-methanediide nanometre-scale rings. Combined
      experimental and computational studies suggest overall the presence of formal
      uranium(III) and (IV) ions, though electron delocalisation in this Kramers system
      cannot be definitively ruled out, and the resulting polarised-covalent U = C
      bonds are supported by iodide and delta-bonded arene bridges. The arenes provide
      reservoirs that accommodate charge, thus avoiding inter-electronic repulsion that
      would destabilise these low oxidation state metal-ligand multiple bonds. Using
      arenes as electronic buffers could constitute a general synthetic strategy by
      which to stabilise otherwise inherently unstable metal-ligand linkages.

PMID- 29844378
TI  - High pCO2-induced exopolysaccharide-rich ballasted aggregates of planktonic
      cyanobacteria could explain Paleoproterozoic carbon burial.
AB  - The contribution of planktonic cyanobacteria to burial of organic carbon in deep
      sea sediments before the emergence of eukaryotic predators ~1.5 Ga has been
      considered negligible owing to the slow sinking speed of their small cells.
      However, global, highly positive excursion in carbon isotope values of inorganic
      carbonates ~2.22-2.06 Ga implies massive organic matter burial that had to be
      linked to oceanic cyanobacteria. Here to elucidate that link, we experiment with
      unicellular planktonic cyanobacteria acclimated to high partial CO2 pressure
      (pCO2) representative of the early Paleoproterozoic. We find that high pCO2
      boosts generation of acidic extracellular polysaccharides (EPS) that adsorb Ca
      and Mg cations, support mineralization, and aggregate cells to form ballasted
      particles. The down flux of such self-assembled cyanobacterial aggregates would
      decouple the oxygenic photosynthesis from oxidative respiration at the ocean
      scale, drive export of organic matter from surface to deep ocean and sustain
      oxygenation of the planetary surface.

PMID- 29844379
TI  - Persistence of Long-lived Memory B Cells specific to Duffy Binding Protein in
      individuals exposed to Plasmodium vivax.
AB  - The major challenge in designing a protective Duffy binding protein region II
      (DBPII)-based vaccine against blood-stage vivax malaria is the high number of
      polymorphisms in critical residues targeted by binding-inhibitory antibodies.
      Here, longevity of antibody and memory B cell response (MBCs) to DBL-TH variants,
      DBL-TH2, -TH4, -TH5, -TH6 and -TH9 were analyzed in P. vivax-exposed individuals
      living in a low malaria transmission area of southern Thailand. Antibody to DBL
      TH variants were significantly detected during P. vivax infection and it was
      persisted for up to 9 months post-infection. However, DBL-TH-specific MBC
      responses were stably maintained longer than antibody response, at least 3 years
      post-infection in the absence of re-infection. Phenotyping of B cell subsets
      showed the expansion of activated and atypical MBCs during acute and recovery
      phase of infection. While the persistence of DBL-TH-specific MBCs was found in
      individuals who had activated and atypical MBC expansion, anti-DBL-TH antibody
      responses was rapidly declined in plasma. The data suggested that these two MBCs
      were triggered by P. vivax infection, its expansion and stability may have impact
      on antibody responses. Our results provided evidence for ability of DBPII variant
      antigens in induction of long-lasting MBCs among individuals who were living in
      low malaria endemicity.

PMID- 29844380
TI  - Novel autoantibody in Sjogren syndrome.

PMID- 29844381
TI  - Changing patterns of lupus nephritis over five decades.

PMID- 29844382
TI  - Tocilizumab or TNF inhibitors in RA?

PMID- 29844383
TI  - Validating canakinumab therapy for autoinflammation.

PMID- 29844384
TI  - The Holocene retreat dynamics and stability of Petermann Glacier in northwest
      Greenland.
AB  - Submarine glacial landforms in fjords are imprints of the dynamic behaviour of
      marine-terminating glaciers and are informative about their most recent retreat
      phase. Here we use detailed multibeam bathymetry to map glacial landforms in
      Petermann Fjord and Nares Strait, northwestern Greenland. A large grounding-zone
      wedge (GZW) demonstrates that Petermann Glacier stabilised at the fjord mouth for
      a considerable time, likely buttressed by an ice shelf. This stability was
      followed by successive backstepping of the ice margin down the GZW's retrograde
      backslope forming small retreat ridges to 680 m current depth (~730-800 m
      palaeodepth). Iceberg ploughmarks occurring somewhat deeper show that thick,
      grounded ice persisted to these water depths before final breakup occurred. The
      palaeodepth limit of the recessional moraines is consistent with final collapse
      driven by marine ice cliff instability (MICI) with retreat to the next stable
      position located underneath the present Petermann ice tongue, where the seafloor
      is unmapped.

PMID- 29844385
TI  - CD24 regulates sorafenib resistance via activating autophagy in hepatocellular
      carcinoma.
AB  - Hepatocellular carcinoma is one of most common solid cancers worldwide. Sorafenib
      is indicated as a treatment for advanced hepatocellular carcinoma (HCC). However,
      the clinical efficacy of sorafenib has been severely compromised by the
      development of drug resistance, and the precise mechanisms of drug resistance
      remain largely unknown. Here we found that a cell surface molecule, CD24, is
      overexpressed in tumor tissues and sorafenib-resistant hepatocellular carcinoma
      cell lines. Moreover, there is a positive correlation between CD24 expression
      levels and sorafenib resistance. In sorafenib-resistant HCC cell lines, depletion
      of CD24 caused a notable increase of sorafenib sensitivity. In addition, we found
      that CD24-related sorafenib resistance was accompanied by the activation of
      autophagy and can be blocked by the inhibition of autophagy using either
      pharmacological inhibitors or essential autophagy gene knockdown. In further
      research, we found that CD24 overexpression also leads to an increase in PP2A
      protein production and induces the deactivation of the mTOR/AKT pathway, which
      enhances the level of autophagy. These results demonstrate that CD24 regulates
      sorafenib resistance via activating autophagy in HCC. This is the first report to
      describe the relationships among CD24, autophagy, and sorafenib resistance. In
      conclusion, the combination of autophagy modulation and CD24 targeted therapy is
      a promising therapeutic strategy in the treatment of HCC.

PMID- 29844386
TI  - The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD
      progression during obesity.
AB  - Aberrant histone methylation profile is reported to correlate with the
      development and progression of NAFLD during obesity. However, the identification
      of specific epigenetic modifiers involved in this process remains poorly
      understood. Here, we identify the histone demethylase Plant Homeodomain Finger 2
      (Phf2) as a new transcriptional co-activator of the transcription factor
      Carbohydrate Responsive Element Binding Protein (ChREBP). By specifically erasing
      H3K9me2 methyl-marks on the promoter of ChREBP-regulated genes, Phf2 facilitates
      incorporation of metabolic precursors into mono-unsaturated fatty acids, leading
      to hepatosteatosis development in the absence of inflammation and insulin
      resistance. Moreover, the Phf2-mediated activation of the transcription factor NF
      E2-related factor 2 (Nrf2) further reroutes glucose fluxes toward the pentose
      phosphate pathway and glutathione biosynthesis, protecting the liver from
      oxidative stress and fibrogenesis in response to diet-induced obesity. Overall,
      our findings establish a downstream epigenetic checkpoint, whereby Phf2, through
      facilitating H3K9me2 demethylation at specific gene promoters, protects liver
      from the pathogenesis progression of NAFLD.

PMID- 29844387
TI  - Male germ cells support long-term propagation of Zika virus.
AB  - Evidence of male-to-female sexual transmission of Zika virus (ZIKV) and viral RNA
      in semen and sperm months after infection supports a potential role for
      testicular cells in ZIKV propagation. Here, we demonstrate that germ cells (GCs)
      are most susceptible to ZIKV. We found that only GCs infected by ZIKV, but not
      those infected by dengue virus and yellow fever virus, produce high levels of
      infectious virus. This observation coincides with decreased expression of
      interferon-stimulated gene Ifi44l in ZIKV-infected GCs, and overexpression of
      Ifi44l results in reduced ZIKV production. Using primary human testicular tissue,
      we demonstrate that human GCs are also permissive for ZIKV infection and
      production. Finally, we identified berberine chloride as a potent inhibitor of
      ZIKV infection in both murine and human testes. Together, these studies identify
      a potential cellular source for propagation of ZIKV in testes and a candidate
      drug for preventing sexual transmission of ZIKV.

PMID- 29844388
TI  - Early transcriptional response of human ovarian and fallopian tube surface
      epithelial cells to norepinephrine.
AB  - Evidence from human and animal studies suggests that chronic behavioral stress
      and resulting activation of the sympathetic nervous system may influence
      initiation and progression of tumors. However, the underlying mechanisms for
      these observations are poorly understood. The purpose of this study is to explore
      the effects of adrenergic signaling on cell line models derived from normal cells
      presumed to originate epithelial ovarian cancers. Here we explored the effects of
      the stress-related hormone, norepinephrine, on the transcriptional program of
      normal immortalized ovarian (iOSE) and fallopian tube (iFTSEC) surface epithelial
      cells. Analysis of RNA-Seq data of treated and untreated cells revealed a
      significant overlap between the responses in iOSE and iFTSEC cells. Most genes
      modulated by norepinephrine in ovarian and fallopian tube epithelial cells are
      already expressed in normal ovarian and fallopian tissue and cells. For several
      genes, expression changes were reflected at the protein level. Genes in immune
      related and developmental pathways were enriched in the set of genes modulated by
      norepinephrine. We identified HOXA5, SPIB, REL, SRF, SP1, NFKB1, MEF2A, E2F1, and
      EGR1 transcription factor binding sites to be highly enriched in our dataset.
      These data represent the early transcriptional response to norepinephrine in
      cells postulated to originate epithelial ovarian cancer.

PMID- 29844389
TI  - Antibody-mediated stabilization of NRG1 induces behavioral and
      electrophysiological alterations in adult mice.
AB  - Neuregulin 1 (NRG1) is required for development of the central and peripheral
      nervous system and regulates neurotransmission in the adult. NRG1 and the gene
      encoding its receptor, ERBB4, are risk genes for schizophrenia, although how
      alterations in these genes disrupt their function has not been fully established.
      Studies of knockout and transgenic mice have yielded conflicting results, with
      both gain and loss of function resulting in similar behavioral and
      electrophysiological phenotypes. Here, we used high affinity antibodies to NRG1
      and ErbB4 to perturb the function of the endogenous proteins in adult mice.
      Treatment with NRG1 antibodies that block receptor binding caused behavioral
      alterations associated with schizophrenia, including, hyper-locomotion and
      impaired pre-pulse inhibition of startle (PPI). Electrophysiological analysis of
      brain slices from anti-NRG1 treated mice revealed reduced synaptic transmission
      and enhanced paired-pulse facilitation. In contrast, mice treated with more
      potent ErbB4 function blocking antibodies did not display behavioral alterations,
      suggesting a receptor independent mechanism of the anti-NRG1-induced phenotypes.
      We demonstrate that anti-NRG1 causes accumulation of the full-length
      transmembrane protein and increases phospho-cofilin levels, which has previously
      been linked to impaired synaptic transmission, indicating enhancement of non
      canonical NRG1 signaling could mediate the CNS effects.

PMID- 29844390
TI  - The hedgehog and Wnt/beta-catenin system machinery mediate myofibroblast
      differentiation of LR-MSCs in pulmonary fibrogenesis.
AB  - Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung
      disease that is characterized by enhanced changes in stem cell differentiation
      and fibroblast proliferation. Resident mesenchymal stem cells (LR-MSCs) can
      undergo phenotype conversion to myofibroblasts to augment extracellular matrix
      production, impairing function and contributing to pulmonary fibrosis. Hedgehog
      and Wnt signaling are developmental signal cascades that play an essential role
      in regulating embryogenesis and tissue homeostasis. Recently, it has been
      reported that both hedgehog and Wnt signaling play important roles in pulmonary
      fibrogenesis. Thus, the identification of specific target regulators may yield
      new strategy for pulmonary fibrosis therapies. In our work, we demonstrated the
      critical role of Gli1, Wnt7b, Wnt10a and Fzd10 in the process of pulmonary
      fibrogenesis in vitro and in vivo. Gli1 was induced in LR-MSCs following TGF
      beta1 treatment and fibrotic lung tissues. Inhibition of Gli1 suppressed
      myofibroblast differentiation of LR-MSCs and pulmonary fibrosis, and decreased
      the expression of Wnt7b, Wnt10a and beta-catenin. Gli1 bound to and increased
      promoter activity of the Wnt7b and Wnt10a genes, and Wnt7b and Wnt10a were
      critical activators of Wnt/beta-catenin signaling. It was noteworthy that Fzd10
      knockdown reduced Wnt7b and Wnt10a-induced activation of Wnt/beta-catenin
      signaling, which imply that Wnt7b and Wnt10a may be the ligands for Fzd10.
      Moreover, siRNA-mediated inhibition of Fzd10 prevented TGF-beta1-induced
      myofibroblast differentiation of LR-MSCs in vitro and impaired bleomycin-induced
      pulmonary fibrosis. We conclude that hedgehog and Wnt/beta-catenin signaling play
      a critical role in promoting myofibroblast differentiation of LR-MSCs and
      development of pulmonary fibrosis. These findings elucidate a therapeutic
      approach to attenuate pulmonary fibrosis through targeted inhibition of Gli1 or
      Fzd10.

PMID- 29844391
TI  - Manipulation of skyrmion motion by magnetic field gradients.
AB  - Magnetic skyrmions are particle-like, topologically protected magnetisation
      entities that are promising candidates as information carriers in racetrack
      memory. The transport of skyrmions in a shift-register-like fashion is crucial
      for their embodiment in practical devices. Here, we demonstrate that chiral
      skyrmions in Cu2OSeO3 can be effectively manipulated under the influence of a
      magnetic field gradient. In a radial field gradient, skyrmions were found to
      rotate collectively, following a given velocity-radius relationship. As a result
      of this relationship, and in competition with the elastic properties of the
      skyrmion lattice, the rotating ensemble disintegrates into a shell-like structure
      of discrete circular racetracks. Upon reversing the field direction, the rotation
      sense reverses. Field gradients therefore offer an effective handle for the fine
      control of skyrmion motion, which is inherently driven by magnon currents. In
      this scheme, no local electric currents are needed, thus presenting a different
      approach to shift-register-type operations based on spin transfer torque.

PMID- 29844392
TI  - Turbulent superstructures in Rayleigh-Benard convection.
AB  - Turbulent Rayleigh-Benard convection displays a large-scale order in the form of
      rolls and cells on lengths larger than the layer height once the fluctuations of
      temperature and velocity are removed. These turbulent superstructures are
      reminiscent of the patterns close to the onset of convection. Here we report
      numerical simulations of turbulent convection in fluids at different Prandtl
      number ranging from 0.005 to 70 and for Rayleigh numbers up to 107. We identify
      characteristic scales and times that separate the fast, small-scale turbulent
      fluctuations from the gradually changing large-scale superstructures. The
      characteristic scales of the large-scale patterns, which change with Prandtl and
      Rayleigh number, are also correlated with the boundary layer dynamics, and in
      particular the clustering of thermal plumes at the top and bottom plates. Our
      analysis suggests a scale separation and thus the existence of a simplified
      description of the turbulent superstructures in geo- and astrophysical settings.

PMID- 29844393
TI  - A fluorescence anisotropy assay to discover and characterize ligands targeting
      the maytansine site of tubulin.
AB  - Microtubule-targeting agents (MTAs) like taxol and vinblastine are among the most
      successful chemotherapeutic drugs against cancer. Here, we describe a
      fluorescence anisotropy-based assay that specifically probes for ligands
      targeting the recently discovered maytansine site of tubulin. Using this assay,
      we have determined the dissociation constants of known maytansine site ligands,
      including the pharmacologically active degradation product of the clinical
      antibody-drug conjugate trastuzumab emtansine. In addition, we discovered that
      the two natural products spongistatin-1 and disorazole Z with established
      cellular potency bind to the maytansine site on beta-tubulin. The high-resolution
      crystal structures of spongistatin-1 and disorazole Z in complex with tubulin
      allowed the definition of an additional sub-site adjacent to the pocket shared by
      all maytansine-site ligands, which could be exploitable as a distinct, separate
      target site for small molecules. Our study provides a basis for the discovery and
      development of next-generation MTAs for the treatment of cancer.

PMID- 29844394
TI  - FHC, an NS4B-interacting Protein, Enhances Classical Swine Fever Virus
      Propagation and Acts Positively in Viral Anti-apoptosis.
AB  - Classical swine fever virus (CSFV), the etiological agent of classical swine
      fever, causes enormous economic loss to the pig industry. Ferritin heavy chain
      (FHC) is a notable anti-apoptotic protein, and existing evidence suggests that
      CSFV cannot induce apoptosis of host cells, however, the role of FHC in CSFV
      replication remains unclear. In the present study, we found that recombinant
      lentivirus-mediated knockdown or overexpression of FHC inhibited or enhanced CSFV
      replication, respectively, indicating a positive role for FHC in CSFV
      proliferation. Furthermore, interaction between the CSFV NS4B protein and FHC was
      confirmed by glutathione S-transferase (GST) pull-down, co-immunoprecipitation
      (co-IP) and confocal imaging assays. In addition, both CSFV replication and NS4B
      expression upregulated expression of FHC, which counteracts apoptosis by
      modulating cellular reactive oxygen species (ROS). These results suggest that
      FHC, an NS4B-interacting protein, enhances CSFV replication and has a positive
      role in viral anti-apoptosis by regulating ROS accumulation. This work may
      provide a new perspective for understanding the mechanism of CSFV pathogenesis.

PMID- 29844395
TI  - Morphological and functional effects of graphene on the synthesis of uranium
      carbide for isotopes production targets.
AB  - The development of tailored targets for the production of radioactive isotopes
      represents an active field in nuclear research. Radioactive beams find
      applications in nuclear medicine, in astrophysics, matter physics and materials
      science. In this work, we study the use of graphene both as carbon source for UO2
      carbothermal reduction to produce UCx targets, and also as functional properties
      booster. At fixed composition, the UCx target grain size, porosity and thermal
      conductivity represent the three main points that affect the target production
      efficiency. UCx was synthesized using both graphite and graphene as the source of
      carbon and the target properties in terms of composition, grain size, porosity,
      thermal diffusivity and thermal conductivity were studied. The main output of
      this work is related to the remarkable enhancement achieved in thermal
      conductivity, which can profitably improve thermal dissipation during operational
      stages of UCx targets.

PMID- 29844396
TI  - A Judgement Bias Test to Assess Affective State and Potential Therapeutics in a
      Rat Model of Chemotherapy-Induced Mucositis.
AB  - Chemotherapy-induced mucositis is an extremely painful condition that occurs in
      40-60% of patients undergoing chemotherapy. As mucositis currently has no
      effective treatment, and due to the self-limiting nature of the condition, the
      major treatment aims are to manage symptoms and limit pain with significance
      placed on improving patient quality of life. Rodent models are frequently used in
      mucositis research. These investigations typically assess pathological outcomes,
      yet fail to include a measure of affective state; the key therapeutic goal.
      Assessment of cognitive biases is a novel approach to determining the affective
      state of animals. Consequently, this study aimed to validate a cognitive bias
      test through a judgement bias paradigm to measure affective state in a rat model
      of chemotherapy-induced intestinal mucositis. Rats with intestinal mucositis
      demonstrated a negative affective state, which was partially ameliorated by
      analgesic administration, whilst healthy rats showed an optimistic response. This
      study concluded that the judgement bias test was able to evaluate the emotional
      state of rats with chemotherapy-induced mucositis. These findings provide a
      foundation for future refinement to the experimental design associated with the
      animal model that will expedite successful transitioning of novel therapeutics to
      clinical practice, and also improve humane endpoint implementation.

PMID- 29844397
TI  - The cyclohexene derivative MC-3129 exhibits antileukemic activity via
      RhoA/ROCK1/PTEN/PI3K/Akt pathway-mediated mitochondrial translocation of cofilin.
AB  - The effects of MC-3129, a synthetic cyclohexene derivative, on cell viability and
      apoptosis have been investigated in human leukemia cells. Exposure of leukemia
      cells to MC-3129 led to the inhibition of cell viability and induction of
      apoptosis through the dephosphorylation and mitochondrial translocation of
      cofilin. A mechanistic study revealed that interruption of the
      RhoA/ROCK1/PTEN/PI3K/Akt signaling pathway plays a crucial role in the MC-3129
      mediated dephosphorylation and mitochondrial translocation of cofilin and
      induction of apoptosis. Our in vivo study also showed that the MC-3129-mediated
      inhibition of the tumor growth in a mouse leukemia xenograft model is associated
      with the interruption of ROCK1/PTEN/PI3K/Akt signaling and apoptosis. Molecular
      docking suggested that MC-3129 might activate the RhoA/ROCK1 pathway by targeting
      LPAR2. Collectively, these findings suggest a hierarchical model, in which the
      induction of apoptosis by MC-3129 primarily results from the activation of
      RhoA/ROCK1/PTEN and inactivation of PI3K/Akt, leading to the dephosphorylation
      and mitochondrial translocation of cofilin, and culminating in cytochrome c
      release, caspase activation, and apoptosis. Our study reveals a novel role for
      RhoA/ROCK1/PTEN/PI3K/Akt signaling in the regulation of mitochondrial
      translocation of cofilin and apoptosis and suggests MC-3129 as a potential drug
      for the treatment of human leukemia.

PMID- 29844399
TI  - Metagenomic insights into the microbial diversity in manganese-contaminated mine
      tailings and their role in biogeochemical cycling of manganese.
AB  - To extend the knowledge on the microbial diversity of manganese rich
      environments, we performed a clone library based study using metagenomic
      approach. Pyrosequencing based analysis of 16S rRNA genes were carried out on an
      Illumina platform to gain insights into the bacterial community inhabiting in a
      manganese mining site and the taxonomic profiles were correlated with the
      inherent capacities of these strains to solubilise manganese. The application of
      shot gun sequencing in this study yielded results which revealed the highest
      prevalence of Proteobacteria (42.47%), followed by Actinobacteria (23.99%) in the
      area of study. Cluster of orthologous group (COG) functional category has 85,066
      predicted functions. Out of which 11% are involved in metabolism of amino acid,
      9% are involved in production and conversion of energy while Keto Encyclopedia of
      Gene and Genomes (KEGG) functional category has 107,388 predicted functions, out
      of which 55% are involved in cellular metabolism, 15% are environmental and
      information processing and 12% are genetic information processing in nature. The
      isolated microbial consortia demonstrated visible growth in presence of high
      concentrations of Mn. Solubilisation studies resulted in 86% of manganese
      recovery after 20 days. The result presented in this study has important
      implications in understanding the microbial diversity in manganese contaminated
      mine tailings and their role in natural geochemical cycling of Mn.

PMID- 29844398
TI  - Single-shot 3D coherent diffractive imaging of core-shell nanoparticles with
      elemental specificity.
AB  - We report 3D coherent diffractive imaging (CDI) of Au/Pd core-shell nanoparticles
      with 6.1 nm spatial resolution with elemental specificity. We measured single
      shot diffraction patterns of the nanoparticles using intense x-ray free electron
      laser pulses. By exploiting the curvature of the Ewald sphere and the symmetry of
      the nanoparticle, we reconstructed the 3D electron density of 34 core-shell
      structures from these diffraction patterns. To extract 3D structural information
      beyond the diffraction signal, we implemented a super-resolution technique by
      taking advantage of CDI's quantitative reconstruction capabilities. We used high
      resolution model fitting to determine the Au core size and the Pd shell thickness
      to be 65.0 +/- 1.0 nm and 4.0 +/- 0.5 nm, respectively. We also identified the 3D
      elemental distribution inside the nanoparticles with an accuracy of 3%. To
      further examine the model fitting procedure, we simulated noisy diffraction
      patterns from a Au/Pd core-shell model and a solid Au model and confirmed the
      validity of the method. We anticipate this super-resolution CDI method can be
      generally used for quantitative 3D imaging of symmetrical nanostructures with
      elemental specificity.

PMID- 29844400
TI  - C-terminal intrinsically disordered region-dependent organization of the
      mycobacterial genome by a histone-like protein.
AB  - The architecture of the genome influences the functions of DNA from bacteria to
      eukaryotes. Intrinsically disordered regions (IDR) of eukaryotic histones have
      pivotal roles in various processes of gene expression. IDR is rare in bacteria,
      but interestingly, mycobacteria produce a unique histone-like protein, MDP1 that
      contains a long C-terminal IDR. Here we analyzed the role of IDR in MDP1
      function. By employing Mycobacterium smegmatis that inducibly expresses MDP1 or
      its IDR-deficient mutant, we observed that MDP1 induces IDR-dependent DNA
      compaction. MDP1-IDR is also responsible for the induction of growth arrest and
      tolerance to isoniazid, a front line tuberculosis drug that kills growing but not
      growth-retardated mycobacteria. We demonstrated that MDP1-deficiency and
      conditional knock out of MDP1 cause spreading of the M. smegmatis genome in the
      stationary phase. This study thus demonstrates for the first time a C-terminal
      region-dependent organization of the genome architecture by MDP1, implying the
      significance of IDR in the function of bacterial histone-like protein.

PMID- 29844401
TI  - Trapping an octahedral Ag6 kernel in a seven-fold symmetric Ag56 nanowheel.
AB  - High-nuclearity silver clusters are appealing synthetic targets for their
      remarkable structures, but most are isolated serendipitously. We report here six
      giant silver-thiolate clusters mediated by solvents, which not only dictate the
      formation of an octahedral Ag64+ kernel, but also influence the in situ-generated
      Mo-based anion templates. The typical sevenfold symmetric silver nanowheels show
      a hierarchical cluster-in-cluster structure that comprises an outermost Ag56
      shell and an inner Ag64+ kernel in the centre with seven MoO42- anion templates
      around it. Electrospray ionization mass spectrometry analyses reveal the
      underlying rule for the formation of such unique silver nanowheels. This work
      establishes a solvent-intervention approach to construct high-nuclearity silver
      clusters in which both the formation of octahedral Ag64+ kernel and in situ
      generation of various Mo-based anion templates can be simultaneously controlled.

PMID- 29844402
TI  - Improved fermentation efficiency of S. cerevisiae by changing glycolytic
      metabolic pathways with plasma agitation.
AB  - Production of ethanol by the yeast Saccharomyces cerevisiae is a process of
      global importance. In these processes, productivities and yields are pushed to
      their maximum possible values leading to cellular stress. Transient and lasting
      enhancements in tolerance and performance have been obtained by genetic
      engineering, forced evolution, and exposure to moderate levels of chemical and/or
      physical stimuli, yet the drawbacks of these methods include cost, and multi
      step, complex and lengthy treatment protocols. Here, plasma agitation is shown to
      rapidly induce desirable phenotypic changes in S. cerevisiae after a single
      treatment, resulting in improved conversion of glucose to ethanol. With a complex
      environment rich in energetic electrons, highly-reactive chemical species,
      photons, and gas flow effects, plasma treatment simultaneously mimics exposure to
      multiple environmental stressors. A single treatment of up to 10 minutes
      performed using an atmospheric pressure plasma jet was sufficient to induce
      changes in cell membrane structure, and increased hexokinase 2 activity and
      secondary metabolite production. These results suggest that plasma treatment is a
      promising strategy that can contribute to improving metabolic activity in
      industrial microbial strains, and thus the practicality and economics of
      industrial fermentations.

PMID- 29844403
TI  - The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau
      phosphorylation and cognitive deficits in an Alzheimer's disease model.
AB  - Alzheimer's disease (AD) is a dreadful neurodegenerative disease that leads to
      severe impairment of cognitive function, leading to a drastic decline in the
      quality of life. The primary pathological features of AD include senile plaques
      (SPs) and intracellular neurofibrillary tangles (NFTs), comprising aggregated
      amyloid beta (Abeta) and hyperphosphorylated tau protein, respectively, in the
      hippocampus of AD patients. Histone deacetylase 6 (HDAC6) is a key enzyme in this
      neurodegenerative disease, in particular, as it relates to tau
      hyperphosphorylation. This study aimed to investigate the protective effects and
      mechanism of the novel HDAC6 inhibitor, MPT0G211, using an AD model. Our results
      indicated that MPT0G211 significantly reduced tau phosphorylation and
      aggregation, the processes highly correlated with the formation of NFTs. This
      HDAC6 inhibitory activity resulted in an increase in acetylated Hsp90, which
      decreased Hsp90 and HDAC6 binding, causing ubiquitination of phosphorylated tau
      proteins. In addition, a significant increase of phospho-glycogen synthase kinase
      3beta (phospho-GSK3beta) on Ser9 (the inactive form) through Akt phosphorylation
      was associated with the inhibition of phospho-tau Ser396 in response to MPT0G211
      treatment. In AD in vivo models, MPT0G211 appeared to ameliorate learning and
      memory impairment in animals. Furthermore, MPT0G211 treatment reduced the amount
      of phosphorylated tau in the hippocampal CA1 region. In summary, MPT0G211
      treatment appears to be a promising strategy for improving the AD phenotypes,
      including tau hyperphosphorylation and aggregation, neurodegeneration, and
      learning and memory impairment, making it a valuable agent for further
      investigation.

PMID- 29844404
TI  - DSGOST regulates resistance via activation of autophagy in gastric cancer.
AB  - Danggui-Sayuk-Ga-Osuyu-Saenggang-Tang (DSGOST in Korean, Danggui-Sini-Jia-Wuzhuyu
      Shengian-Tang in Chinese, and Tokishigyakukagoshuyushokyoto (TJ-38) in Japanese),
      a well-known traditional Korean/Chinese/Japanese medicine, has long been used to
      treat vascular diseases such as Raynaud's phenomenon (RP). However, anticancer
      effect of DSGOST remains elusive. In this study, we checked if DSGOST has an
      anticancer effect against gastric cancer cells, and investigated the mechanisms
      underlying DSGOST resistance. Moreover, DSGOST regulates chemoresistance in
      cisplatin-treated gastric cancer cells. Interestingly, DSGOST treatment induced
      the accumulation of GFP-LC3 puncta and increased the level of autophagy markers,
      such as LC3-II, ATG5, and Beclin-1, indicating activated autophagy. Furthermore,
      DSGOST could activate epithelial-to-mesenchymal transition (EMT) and exosomes via
      induction of autophagy. DSGOST in combination with TGFbeta also induced autophagy
      and EMT. However, autophagy inhibition induces DSGOST-mediated cell death in
      gastric cancer cells. In addition, autophagy inhibition blocks the activation of
      DSGOST-mediated EMT markers including N-cadherin, Snail, Slug, vimentin, beta
      catenin, p-Smad2, and p-Smad3. Taken together, these findings indicated that
      prosurvival autophagy was one of the mechanisms involved in the resistance of
      gastric cancer to DSGOST. Targeting the inhibition of autophagy could be an
      effective therapeutic approach to overcome resistance to DSGOST in gastric
      cancer.

PMID- 29844405
TI  - Amorphous topological superconductivity in a Shiba glass.
AB  - Topological states of matter support quantised nondissipative responses and
      exotic quantum particles that cannot be accessed in common materials. The
      exceptional properties and application potential of topological materials have
      triggered a large-scale search for new realisations. Breaking away from the
      popular trend focusing almost exclusively on crystalline symmetries, we introduce
      the Shiba glass as a platform for amorphous topological quantum matter. This
      system consists of an ensemble of randomly distributed magnetic atoms on a
      superconducting surface. We show that subgap Yu-Shiba-Rusinov states on the
      magnetic moments form a topological superconducting phase at critical density
      despite a complete absence of spatial order. Experimental signatures of the
      amorphous topological state can be obtained by scanning tunnelling microscopy
      measurements probing the topological edge mode. Our discovery demonstrates the
      physical feasibility of amorphous topological quantum matter, presenting a
      concrete route to fabricating new topological systems from nontopological
      materials with random dopants.

PMID- 29844406
TI  - Correction: MicroRNA-27a promotes podocyte injury via PPARgamma-mediated beta
      catenin activation in diabetic nephropathy.
AB  - Correction to: Cell Death and Disease 8, e2658 (2017);
      https://doi.org/10.1038/cddis.2017.74 ; published online 9 March 2017.

PMID- 29844408
TI  - Improved thermoelectric performance of solid solution Cu4Sn7.5S16 through
      isoelectronic substitution of Se for S.
AB  - Cu-Sn-S family of compounds have been considered as very competitive
      thermoelectric candidates in recent years due to their abundance and eco
      friendliness. The first-principles calculation reveals that the density of states
      (DOS) increases in the vicinity of the Fermi level (Ef) upon an incorporation of
      Se in the Cu4Sn7.5S16-xSe x (x = 0-2.0) system, which indicates the occurrence of
      resonant states. Besides, the formation of Cu(Sn)-Se network upon the occupation
      of Se in S site reduces the Debye temperature from 395 K for Cu4Sn7S16 (x = 0) to
      180.8 K for Cu4Sn7.5S16-xSe x (x = 1.0). Although the point defects mainly impact
      the phonon scattering, an electron-phonon interaction also bears significance in
      the increase in phonon scattering and the further reducion of lattice thermal
      conductivity at high temperatures. As a consequence, the resultant TE figure of
      merit (ZT) reaches 0.5 at 873 K, which is 25% higher compared to 0.4 for
      Cu4Sn7.5S16.

PMID- 29844409
TI  - Probiotic supplementation and associated infant gut microbiome and health: a
      cautionary retrospective clinical comparison.
AB  - While probiotics are a multi-billion dollar industry, there is little evidence to
      show that supplementing infants provides any health benefits. We conducted an
      observational study where 35 of 86 participating mothers self-administered
      probiotics during breastfeeding, as well as directly to their infants. The
      primary objective was to determine if probiotic exposure influenced the infants'
      fecal microbiome while the secondary objective assessed associated changes to the
      mothers' breast milk immunity and infant health. Analysis of infant fecal
      microbiome throughout the first 6 months of life revealed that probiotics were
      associated with higher abundances of Bifidobacterium at week 1 only. Short-chain
      fatty acid production and predicted metagenomic functions of the microbial
      communities were not altered. While probiotics did not alter breast milk immune
      markers, fecal sIgA responses were higher among probiotic supplemented infants.
      Surprisingly, this was not associated with better health outcomes, as the
      probiotic cohort had higher incidences of mucosal-associated illnesses as
      toddlers. This retrospective clinical comparison suggests that probiotic exposure
      during infancy has limited effects on gut microbial composition yet is associated
      with increased infection later in life. These correlative findings caution
      against probiotic supplementation during infancy until rigorous controlled follow
      up studies determining their safety and efficacy have occurred.

PMID- 29844410
TI  - MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic
      ductal adenocarcinoma by hypermethylation of its locus.
AB  - Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease with
      poor prognostic implications. This is partly due to a large proportion of PDACs
      carrying mutations in TP53, which impart gain-of-function characteristics that
      promote metastasis. There is evidence that microRNAs (miRNAs) may play a role in
      both gain-of-function TP53 mutations and metastasis, but this has not been fully
      explored in PDAC. Here we set out to identify miRNAs which are specifically
      dysregulated in metastatic PDAC. To achieve this, we utilised established mouse
      models of PDAC to profile miRNA expression in primary tumours expressing the
      metastasis-inducing mutant p53R172H and compared these to two control models
      carrying mutations, which promote tumour progression but do not induce
      metastasis. We show that a subset of miRNAs are dysregulated in mouse PDAC tumour
      tissues expressing mutant p53R172H, primary cell lines derived from mice with the
      same mutations and in TP53 null cells with ectopic expression of the orthologous
      human mutation, p53R175H. Specifically, miR-142-3p is downregulated in all of
      these experimental models. We found that DNA methyltransferase 1 (Dnmt1) is
      upregulated in tumour tissue and cell lines, which express p53R172H. Inhibition
      or depletion of Dnmt1 restores miR-142-3p expression. Overexpression of miR-142
      3p attenuates the invasive capacity of p53R172H-expressing tumour cells. MiR-142
      3p dysregulation is known to be associated with cancer progression, metastasis
      and the miRNA is downregulated in patients with PDAC. Here we link TP53 gain-of
      function mutations to Dnmt1 expression and in turn miR-142-3p expression.
      Additionally, we show a correlation between expression of these genes and patient
      survival, suggesting that they may have potential to be therapeutic targets.

PMID- 29844411
TI  - Author Correction: Dynamic thylakoid stacking regulates the balance between
      linear and cyclic photosynthetic electron transfer.
AB  - In the version of this Article originally published, the authors incorrectly
      labelled the timescale in Fig. 6b as milliseconds (ms) on the x axis and the
      indicated half-life values; the correct units are microseconds (MUs). The figure
      has now been amended in all versions of the Article.

PMID- 29844412
TI  - Mitochondrial imaging in live or fixed tissues using a luminescent iridium
      complex.
AB  - Mitochondrial morphology is important for the function of this critical organelle
      and, accordingly, altered mitochondrial structure is exhibited in many
      pathologies. Imaging of mitochondria can therefore provide important information
      about disease presence and progression. However, mitochondrial imaging is
      currently limited by the availability of agents that have the capacity to image
      mitochondrial morphology in both live and fixed samples. This can be particularly
      problematic in clinical studies or large, multi-centre cohort studies, where
      tissue archiving by fixation is often more practical. We previously reported the
      synthesis of an iridium coordination complex [Ir(ppy)2(MeTzPyPhCN)]+; where ppy
      is a cyclometalated 2-phenylpyridine and TzPyPhCN is the 5-(5-(4-cyanophen-1
      yl)pyrid-2-yl)tetrazolate ligand; and showed that this complex (herein referred
      to as IraZolve-Mito) has a high specificity for mitochondria in live cells. Here
      we demonstrate that IraZolve-Mito can also effectively stain mitochondria in both
      live and fixed tissue samples. The staining protocol proposed is versatile,
      providing a universal procedure for cell biologists and pathologists to visualise
      mitochondria.

PMID- 29844413
TI  - Rate and Temporal Coding Mechanisms in the Anterior Cingulate Cortex for Pain
      Anticipation.
AB  - Pain is a complex sensory and affective experience. Through its anticipation,
      animals can learn to avoid pain. Much is known about passive avoidance during a
      painful event; however, less is known about active pain avoidance. The anterior
      cingulate cortex (ACC) is a critical hub for affective pain processing. However,
      there is currently no mechanism that links ACC activities at the cellular level
      with behavioral anticipation or avoidance. Here we asked whether distinct
      populations of neurons in the ACC can encode information for pain anticipation.
      We used tetrodes to record from ACC neurons during a conditioning assay to train
      rats to avoid pain. We found that in rats that successfully avoid acute pain
      episodes, neurons that responded to pain shifted their firing rates to an earlier
      time, whereas neurons that responded to the anticipation of pain increased their
      firing rates prior to noxious stimulation. Furthermore, we found a selected group
      of neurons that shifted their firing from a pain-tuned response to an
      anticipatory response. Unsupervised learning analysis of ensemble spike activity
      indicates that temporal spiking patterns of ACC neurons can indeed predict the
      onset of pain avoidance. These results suggest rate and temporal coding schemes
      in the ACC for pain avoidance.

PMID- 29844414
TI  - Effect of religion on hypertension in adult Buddhists and residents in China: A
      cross-sectional study.
AB  - Correlation between religion and hypertension is worth investigating since they
      both influence many people. Compared to studies which quantify religion with
      indicators representing only restricted dimensions of religion, researches
      assessing religion as an integral is preferable while lacking. Moreover,
      religious behaviors have great potential to be generalized if they are proved to
      be mediator through which religion exerts effect. However, relevant evidence is
      limited. Therefore, this cross-sectional study recruited 1384 adult Tibetan
      Buddhists from two Buddhist institutes in the Sichuan Province of China, and
      enrolled 798 adult Tibetan residents from nearby villages/towns. Each participant
      received a questionnaire, physical examination, and blood biochemistry tests.
      Buddhist effect on hypertension was investigated. The effects of uniquely
      Buddhist behaviors on hypertension were analyzed. The hypertensive risk of the
      Tibetan Buddhists is significantly decreased by 38% than Tibetan residents. As a
      Buddhist behavior, vegetarian diet highly approximates to be protective for
      Tibetan hypertension. As another Buddhist behavior, longer Buddhist activity
      participation time is associated with decreased prevalence of hypertension as
      well as lower blood pressure (BP) by analyzing subgroup of 570 Buddhists.
      Therefore, the protective role of religion on hypertension is suggested, and the
      religious behaviors are mediators which may be applied to general population.

PMID- 29844415
TI  - Regulation of cortical activity and arousal by the matrix cells of the
      ventromedial thalamic nucleus.
AB  - The "non-specific" ventromedial thalamic nucleus (VM) has long been considered a
      candidate for mediating cortical arousal due to its diffuse, superficial
      projections, but direct evidence was lacking. Here, we show in mice that the
      activity of VM calbindin1-positive matrix cells is high in wake and REM sleep and
      low in NREM sleep, and increases before cortical activity at the sleep-to-wake
      transition. Optogenetic stimulation of VM cells rapidly awoke all mice from NREM
      sleep and consistently caused EEG activation during slow wave anesthesia, while
      arousal did not occur from REM sleep. Conversely, chemogenetic inhibition of VM
      decreased wake duration. Optogenetic activation of the "specific" ventral
      posteromedial nucleus (VPM) did not cause arousal from either NREM or REM sleep.
      Thus, matrix cells in VM produce arousal and broad cortical activation during
      NREM sleep and slow wave anesthesia in a way that accounts for the effects
      classically attributed to "non-specific" thalamic nuclei.

PMID- 29844416
TI  - Role of TREM-1 in pulmonary tuberculosis patients- analysis of serum soluble TREM
      1 levels.
AB  - Triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammatory
      responses and is upregulated during sepsis and pulmonary infection. The
      association between serum soluble TREM-1 (sTREM-1) level and pulmonary
      tuberculosis (PTB) disease deserves investigation. In the present study, patients
      with PTB, latent TB infection (LTBI), and non-TB, non-LTBI subjects were
      prospectively enrolled and serum levels of sTREM-1, sTREM-2, and C-reactive
      protein (CRP) were measured. We correlated serum biomarkers and clinical
      presentations and treatment outcomes of PTB cases. We also utilized
      immunohistochemistry (IHC) to visualize TREM-1-expressing cells in lung tissues
      from PTB patients. A total of 86 PTB, 41 LTBI, and 20 non-TB, non-LTBI subjects
      were enrolled. Serum levels of sTREM-1 and CRP significantly increased in PTB
      patients; these higher serum levels were correlated with more advanced
      involvement in chest films and higher bacteria burden in sputum. In multivariate
      analysis, serum levels of sTREM-1 >260 pg/mL and CRP >2.6 mg/L were independent
      predictors for on-treatment mortality. Abundant TREM-1-expressing macrophages
      were identified in lung tissues from PTB samples. In conclusion, serum levels of
      sTREM-1 correlated with disease severity and treatment outcomes in PTB patients.

PMID- 29844417
TI  - Quantum Monte Carlo simulations of a giant {Ni21Gd20} cage with a S = 91 spin
      ground state.
AB  - The detailed analysis of magnetic interactions in a giant molecule is difficult
      both because the synthesis of such compounds is challenging and the number of
      energy levels increases exponentially with the magnitude and number of spins.
      Here, we isolated a {Ni21Gd20} nanocage with a large number of energy levels (~5
      * 1030) and used quantum Monte Carlo (QMC) simulations to perform a detailed
      analysis of magnetic interactions. Based on magnetization measurements above 2 K,
      the QMC simulations predicted very weak ferromagnetic interactions that would
      give a record S = 91 spin ground state. Low-temperature measurements confirm the
      spin ground state but suggest a more complex picture due to the single ion
      anisotropy; this has also been modeled using the QMC approach. The high spin and
      large number of low-lying states lead to a large low-field magnetic entropy (14.1
      J kg-1 K-1 for DeltaH = 1 T at 1.1 K) for this material.

PMID- 29844418
TI  - Bacterial Communities Changes during Food Waste Spoilage.
AB  - Food waste is an important component of municipal solid waste worldwide. There
      are various ways to treat or utilize food waste, such as, biogas fermentation,
      animal feed, etc. but pathogens and mycotoxins that accumulate in the process of
      spoilage can present a health hazard. However, spoilage of food waste has not yet
      been studied, and there are no reports of the bacterial communities present in
      this waste. In this research, food waste was collected and placed at two
      different temperatures. We investigated the spoilage microbiota by using culture
      independent methods and measured the possible mycotoxins may appear in the
      spoilage process. The results showed that lactic acid bacteria are the most
      important bacteria in the food waste community, regardless of the temperature.
      Few microbial pathogens and aflatoxins were found in the spoilage process. This
      suggests that if food waste is stored at a relatively low temperature and for a
      short duration, there will be less risk for utilization.

PMID- 29844419
TI  - The degree of prevalence of similarity between outer tropical cyclone rainbands
      and squall lines.
AB  - Tropical cyclone rainbands (TCRs) are not only one of the most striking and
      persistent features of tropical cyclones (TCs) but also one of the major causes
      for extreme floods as TCs approach or encounter the land area. TCRs have been
      traditionally considered as manifestations of atmospheric waves initiated near
      the eyewall or close to the TC center. However, the limited evidence from recent
      studies showed the possibility for TCRs to develop squall-line-like
      characteristics in the outer region of TCs. In this study, the degree of the
      prevalence for this similarity is explored by radar and surface observations from
      a large set of 50 outer TCRs associated with 22 TCs as they approached Taiwan.
      The results indicate that around 58% of outer TCRs are similar to squall lines.
      These outer TCRs are generally characterized by convective precipitation, an
      obvious convergence zone between the band-relative rear-to-front flow and front
      to-rear flow at low levels, either frontward or rearward tilting updrafts, and a
      surface cold pool signature. The frequent similarity between the outer TCRs and
      squall lines documented provides important insights into the formation of
      organized, heavy precipitation associated with TCs.

PMID- 29844420
TI  - The feasibility and stability of large complex biological networks: a random
      matrix approach.
AB  - In the 70's, Robert May demonstrated that complexity creates instability in
      generic models of ecological networks having random interaction matrices A.
      Similar random matrix models have since been applied in many disciplines. Central
      to assessing stability is the "circular law" since it describes the eigenvalue
      distribution for an important class of random matrices A. However, despite
      widespread adoption, the "circular law" does not apply for ecological systems in
      which density-dependence operates (i.e., where a species growth is determined by
      its density). Instead one needs to study the far more complicated eigenvalue
      distribution of the community matrix S = DA, where D is a diagonal matrix of
      population equilibrium values. Here we obtain this eigenvalue distribution. We
      show that if the random matrix A is locally stable, the community matrix S = DA
      will also be locally stable, providing the system is feasible (i.e., all species
      have positive equilibria D > 0). This helps explain why, unusually, nearly all
      feasible systems studied here are locally stable. Large complex systems may thus
      be even more fragile than May predicted, given the difficulty of assembling a
      feasible system. It was also found that the degree of stability, or resilience of
      a system, depended on the minimum equilibrium population.

PMID- 29844421
TI  - Signal and noise extraction from analog memory elements for neuromorphic
      computing.
AB  - Dense crossbar arrays of non-volatile memory (NVM) can potentially enable
      massively parallel and highly energy-efficient neuromorphic computing systems.
      The key requirements for the NVM elements are continuous (analog-like)
      conductance tuning capability and switching symmetry with acceptable noise
      levels. However, most NVM devices show non-linear and asymmetric switching
      behaviors. Such non-linear behaviors render separation of signal and noise
      extremely difficult with conventional characterization techniques. In this study,
      we establish a practical methodology based on Gaussian process regression to
      address this issue. The methodology is agnostic to switching mechanisms and
      applicable to various NVM devices. We show tradeoff between switching symmetry
      and signal-to-noise ratio for HfO2-based resistive random access memory. Then, we
      characterize 1000 phase-change memory devices based on Ge2Sb2Te5 and separate
      total variability into device-to-device variability and inherent randomness from
      individual devices. These results highlight the usefulness of our methodology to
      realize ideal NVM devices for neuromorphic computing.

PMID- 29844422
TI  - The hepcidin-ferroportin axis controls the iron content of Salmonella-containing
      vacuoles in macrophages.
AB  - Macrophages release iron into the bloodstream via a membrane-bound iron export
      protein, ferroportin (FPN). The hepatic iron-regulatory hormone hepcidin controls
      FPN internalization and degradation in response to bacterial infection.
      Salmonella typhimurium can invade macrophages and proliferate in the Salmonella
      containing vacuole (SCV). Hepcidin is reported to increase the mortality of
      Salmonella-infected animals by increasing the bacterial load in macrophages. Here
      we assess the iron levels and find that hepcidin increases iron content in the
      cytosol but decreases it in the SCV through FPN on the SCV membrane. Loss-of-FPN
      from the SCV via the action of hepcidin impairs the generation of bactericidal
      reactive oxygen species (ROS) as the iron content decreases. We conclude that FPN
      is required to provide sufficient iron to the SCV, where iron serves as a
      cofactor for the generation of antimicrobial ROS rather than as a nutrient for
      Salmonella.

PMID- 29844423
TI  - Different combination strategies for prophylaxis of venous thromboembolism in
      patients: A prospective multicenter randomized controlled study.
AB  - The aim was to evaluate the efficacy and safety of different combination
      strategies for prophylaxis of venous thromboembolism (VTE) after gynecologic
      surgery in patients at different levels of risk. This was a prospective
      multicenter randomized controlled study, in which 625 women who would undergo
      pelvic surgery for gynecologic diseases were stratified into three risk groups
      and then randomized into four groups to receive graduated compression stockings
      (GCS) alone (group A), GCS + low molecular weight heparin (LMWH) (group B), GCS +
      intermittent pneumatic compression (IPC) (group C), and GCS + IPC + LMWH (group
      C), respectively. The overall incidence of DVT was 5.1%. Group A had the highest
      incidence of DVT (8.8%), followed by group C (5.2%), group B (3.8%), and group D
      (2.6%). There was a significant difference in the incidence of DVT between groups
      A and D. The incidence of DVT was significantly lower in LMWH-treated patients
      (group B + group D) than in non-LMWH-treated patients (group A + group C). In
      conclusion, combination prophylaxis, especially LMWH-containing strategies, is
      better than monoprophylaxis in reducing VTE after gynecologic surgery. Risk
      stratified prophylactic strategies should be implemented in patients undergoing
      gynecologic surgery, with LMWH-containing strategies being recommended for high
      risk and very-high-risk patients.

PMID- 29844424
TI  - Increased H3K27ac level of ACE mediates the intergenerational effect of low peak
      bone mass induced by prenatal dexamethasone exposure in male offspring rats.
AB  - Prenatal dexamethasone exposure (PDE) induces developmental toxicities of
      multiple organs in offspring. Here, we verified the intergenerational effect of
      low peak bone mass induced by PDE and investigated its intrauterine programming
      mechanism. Pregnant rats were injected subcutaneously with 0.2 mg/kg/d
      dexamethasone from gestation day (GD) 9 to 20. Some pregnant rats were killed for
      the fetuses on GD20, and the rest went on to spontaneous labor to produce the
      first-generation (F1) offspring. The adult F1 male offspring were mated with
      normal females to produce the F2 offspring. In vivo, PDE leads to low peak bone
      mass in F1 male offspring rats at postnatal week (PW) 28. Furthermore, PDE
      reduced the bone mass in F1 male offspring from GD20 to PW12. Meanwhile, the
      osteogenic differentiation was suppressed and the local renin-angiotensin system
      (RAS) was activated continuously by PDE. Moreover, the histone 3 lysine 27
      acetylation (H3K27ac) level in angiotensin-converting enzyme (ACE) promoter
      region was increased by PDE from GD20 to PW12. Likewise, PDE induced the low peak
      bone mass and the activated local RAS in F2 male offspring. Meaningfully, the
      H3K27ac level of ACE was increased by PDE in the F2 offspring. In vitro,
      dexamethasone inhibited bone marrow mesenchymal stem cells (BMSCs) osteogenic
      differentiation and promoted RAS activation. Furthermore, dexamethasone recruited
      CCAAT/enhancer-binding protein alpha and p300 into the BMSCs nucleus by
      activating glucocorticoid receptor, which cooperatively increased the H3K27ac
      level in the ACE promoter region. In conclusion, PDE induced the low peak bone
      mass and its intergenerational effect, which was mediated by sustained activation
      of RAS via increasing H3K27ac level of ACE.

PMID- 29844425
TI  - The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones.
AB  - R2TP is an HSP90 co-chaperone that assembles important macro-molecular
      machineries. It is composed of an RPAP3-PIH1D1 heterodimer, which binds the two
      essential AAA+ATPases RUVBL1/RUVBL2. Here, we resolve the structure of the
      conserved C-terminal domain of RPAP3, and we show that it directly binds
      RUVBL1/RUVBL2 hexamers. The human genome encodes two other proteins bearing RPAP3
      C-terminal-like domains and three containing PIH-like domains. Systematic
      interaction analyses show that one RPAP3-like protein, SPAG1, binds PIH1D2 and
      RUVBL1/2 to form an R2TP-like complex termed R2SP. This co-chaperone is enriched
      in testis and among 68 of the potential clients identified, some are expressed in
      testis and others are ubiquitous. One substrate is liprin-alpha2, which organizes
      large signaling complexes. Remarkably, R2SP is required for liprin-alpha2
      expression and for the assembly of liprin-alpha2 complexes, indicating that R2SP
      functions in quaternary protein folding. Effects are stronger at 32  degrees C,
      suggesting that R2SP could help compensating the lower temperate of testis.

PMID- 29844426
TI  - Cortical BOLD responses to moderate- and high-speed motion in the human visual
      cortex.
AB  - We investigated the BOLD response of visual cortical and sub-cortical regions to
      fast drifting motion presented over wide fields, including the far periphery.
      Stimuli were sinusoidal gratings of 50% contrast moving at moderate and very high
      speeds (38 and 570  degrees /s), projected to a large field of view (~60 degrees
      ). Both stimuli generated strong and balanced responses in the lateral geniculate
      nucleus and the superior colliculus. In visual cortical areas, responses were
      evaluated at three different eccentricities: central 0-15 degrees ; peripheral 20
      30 degrees ; and extreme peripheral 30-60 degrees . "Ventral stream" areas (V2,
      V3, V4) preferred moderate-speeds in the central visual field, while motion area
      MT+ responded equally well to both speeds at all eccentricities. In all other
      areas and eccentricities BOLD responses were significant and equally strong for
      both types of moving stimuli. Support vector machine showed that the direction of
      the fast-speed motion could be successfully decoded from the BOLD response in all
      visual areas, suggesting that responses are mediated by motion mechanisms rather
      than being an unspecific preference for fast rate of flicker. The results show
      that the visual cortex responds to very fast motion, at speeds generated when we
      move our eyes rapidly, or when moving objects pass by closely.

PMID- 29844427
TI  - Pharmacologic inhibition of protein phosphatase-2A achieves durable immune
      mediated antitumor activity when combined with PD-1 blockade.
AB  - Mounting evidence suggests that inhibition of protein phosphatase-2A (PP2A), a
      serine/threonine phosphatase, could enhance anticancer immunity. However, drugs
      targeting PP2A are not currently available. Here, we report that a PP2A
      inhibitor, LB-100, when combined with anti-PD-1 (aPD-1) blockade can
      synergistically elicit a durable immune-mediated antitumor response in a murine
      CT26 colon cancer model. This effect is T-cell dependent, leading to regression
      of a significant proportion of tumors. Analysis of tumor lymphocytes demonstrates
      enhanced effector T-cell and reduced suppressive regulatory T-cell infiltration.
      Clearance of tumor establishes antigen-specific secondary protective immunity. A
      synergistic effect of LB-100 and aPD-1 blockade is also observed in B16 melanoma
      model. In addition, LB-100 activates the mTORC1 signaling pathway resulting in
      decreased differentiation of naive CD4 cells into regulatory T cells. There is
      also increased expression of Th1 and decreased expression of Th2 cytokines. These
      data highlight the translational potential of PP2A inhibition in combination with
      checkpoint inhibition.

PMID- 29844428
TI  - Anatomy of interfacial spin-orbit coupling in Co/Pd multilayers using X-ray
      magnetic circular dichroism and first-principles calculations.
AB  - Element-specific orbital magnetic moments and their anisotropies in
      perpendicularly magnetised Co/Pd multilayers are investigated using Co L-edge and
      Pd M-edge angle-dependent x-ray magnetic circular dichroism. We show that the
      orbital magnetic moments in Co are anisotropic, whereas those in Pd are
      isotropic. The first-principles density-functional-theory calculations also
      suggest that the Co/Pd interfacial orbital magnetic moments in Co are anisotropic
      and contribute to the perpendicular magnetic anisotropy (PMA), and that the
      isotropic ones in Pd manipulates the Co orbitals at the interface through
      proximity effects. Orbital-resolved anatomy of Co/Pd interfaces reveals that the
      orbital moment anisotropy in Co and spin-flipped transition related to the
      magnetic dipoles in Pd are essential for the appearance of PMA.

PMID- 29844429
TI  - A MYST Histone Acetyltransferase Modulates Conidia Development and Secondary
      Metabolism in Pestalotiopsis microspora, a Taxol Producer.
AB  - Reverse genetics is a promising strategy for elucidating the regulatory
      mechanisms involved in secondary metabolism and development in fungi. Previous
      studies have demonstrated the key role of histone acetyltransferases in
      transcriptional regulation. Here, we identified a MYST family histone
      acetyltransferase encoding gene, mst2, in the filamentous fungus Pestalotiopsis
      microspora NK17 and revealed its role in development and secondary metabolism.
      The gene mst2 showed temporal expression that corresponded to the conidiation
      process in the wild-type strain. Deletion of mst2 resulted in serious growth
      retardation and impaired conidial development, e.g., a delay and reduced capacity
      of conidiation and aberrant conidia. Overexpression of mst2 triggered earlier
      conidiation and higher conidial production. Additionally, deletion of mst2 led to
      abnormal germination of the conidia and caused cell wall defects. Most
      significantly, by HPLC profiling, we found that loss of mst2 diminished the
      production of secondary metabolites in the fungus. Our data suggest that mst2 may
      function as a general mediator in growth, secondary metabolism and morphological
      development.

PMID- 29844430
TI  - Gravity modeling finds a large magma body in the deep crust below the Gulf of
      Naples, Italy.
AB  - We analyze a wide gravity low in the Campania Active Volcanic Area and interpret
      it by a large and deep source distribution of partially molten, low-density
      material from about 8 to 30 km depth. Given the complex spatial-temporal
      distribution of explosive volcanism in the area, we model the gravity data
      consistently with several volcanological and petrological constraints. We propose
      two possible models: one accounts for the coexistence, within the
      lower/intermediate crust, of large amounts of melts and cumulates besides country
      rocks. It implies a layered distribution of densities and, thus, a variation with
      depth of percentages of silicate liquids, cumulates and country rocks. The other
      reflects a fractal density distribution, based on the scaling exponent estimated
      from the gravity data. According to this model, the gravity low would be related
      to a distribution of melt pockets within solid rocks. Both density distributions
      account for the available volcanological and seismic constraints and can be
      considered as end-members of possible models compatible with gravity data. Such
      results agree with the general views about the roots of large areas of
      ignimbritic volcanism worldwide. Given the prolonged history of magmatism in the
      Campania area since Pliocene times, we interpret the detected low-density body as
      a developing batholith.

PMID- 29844432
TI  - A rose on the garden fair.

PMID- 29844433
TI  - The genomic floral language of rose.

PMID- 29844431
TI  - Excitation and injury of adult ventricular cardiomyocytes by nano- to millisecond
      electric shocks.
AB  - Intense electric shocks of nanosecond (ns) duration can become a new modality for
      more efficient but safer defibrillation. We extended strength-duration curves for
      excitation of cardiomyocytes down to 200 ns, and compared electroporative damage
      by proportionally more intense shocks of different duration. Enzymatically
      isolated murine, rabbit, and swine adult ventricular cardiomyocytes (VCM) were
      loaded with a Ca2+ indicator Fluo-4 or Fluo-5N and subjected to shocks of
      increasing amplitude until a Ca2+ transient was optically detected. Then, the
      voltage was increased 5-fold, and the electric cell injury was quantified by the
      uptake of a membrane permeability marker dye, propidium iodide. We established
      that: (1) Stimuli down to 200-ns duration can elicit Ca2+ transients, although
      repeated ns shocks often evoke abnormal responses, (2) Stimulation thresholds
      expectedly increase as the shock duration decreases, similarly for VCMs from
      different species, (3) Stimulation threshold energy is minimal for the shortest
      shocks, (4) VCM orientation with respect to the electric field does not affect
      the threshold for ns shocks, and (5) The shortest shocks cause the least
      electroporation injury. These findings support further exploration of ns
      defibrillation, although abnormal response patterns to repetitive ns stimuli are
      of a concern and require mechanistic analysis.

PMID- 29844434
TI  - Hepatocyte Growth Factor (HGF) Promotes Peripheral Nerve Regeneration by
      Activating Repair Schwann Cells.
AB  - During the peripheral nerve regeneration process, a variety of neurotrophic
      factors play roles in nerve repair by acting on neuronal or non-neuronal cells.
      In this report, we investigated the role(s) of hepatocyte growth factor (HGF) and
      its receptor, c-met, in peripheral nerve regeneration. When mice were subjected
      to sciatic nerve injury, the HGF protein level was highly increased at the
      injured and distal sites. The level of both total and phosphorylated c-met was
      also highly upregulated, but almost exclusively in Schwann cells (SCs) distal
      from the injury site. When mice were treated with a c-met inhibitor, PHA-665752,
      myelin thickness and axon regrowth were decreased indicating that re-myelination
      was hindered. HGF promoted the migration and proliferation of cultured SCs, and
      also induced the expression of various genes such as GDNF and LIF, presumably by
      activating ERK pathways. Furthermore, exogenous supply of HGF around the injury
      site, by intramuscular injection of a plasmid DNA expressing human HGF, enhanced
      the myelin thickness and axon diameter in injured nerves. Taken together, our
      results indicate that HGF and c-met play important roles in Schwann cell-mediated
      nerve repair, and also that HGF gene transfer may provide a useful tool for
      treating peripheral neuropathy.

PMID- 29844435
TI  - Profiling and functional analysis of circular RNAs in acute promyelocytic
      leukemia and their dynamic regulation during all-trans retinoic acid treatment.
AB  - Circular RNAs (circRNAs) are a novel class of powerful regulators in gene
      expression and participate in the pathogenesis of many diseases, including
      cancer. However, little is known about the roles of circRNAs in the development
      and treatment of acute promyelocytic leukemia (APL). Here we report the
      expression profiling and function of circRNAs in APL, including their dynamic
      regulation during all-trans retinoic acid (ATRA)-induced differentiation. We
      performed two independent ribosomal RNA-minus RNA-sequencing (Ribo-minus RNA-seq)
      experiments with and without RNase R treatment on APL patient-derived NB4 cells
      and identified a total of 4313 circRNAs, including 1098 newly identified
      circRNAs. Detailed analysis showed that circRNAs expressed in APL cells were
      mostly exon-derived, not by-products during splicing, and could be distinguished
      from hematopoietic stem cells, neutrophils and lymphocytes. The true presence and
      stability of circRNAs were verified both in NB4 cells and primary APL patient
      samples. Moreover, we conducted a time-series analysis of circRNAs on ATRA
      treated NB4 cells and uncovered 508 circRNAs with dynamic expression during ATRA
      treatment, including 246 upregulated and 262 downregulated. Further evidence
      demonstrated that the majority of circRNAs were regulated independently of their
      host linear mRNAs. Detailed functional experiments demonstrated that circ-HIPK2,
      one of the differentially expressed circRNAs, significantly influenced ATRA
      induced differentiation of APL cells. Further mechanistic studies revealed that
      circ-HIPK2 was located in cytoplasm and served as a sponge for differentiation
      associated miR-124-3p. Finally, circ-HIPK2 expression in APL patients was
      significantly lower than that in normal peripheral mononuclear cells and other
      subtypes of AML, indicating its potential role as an APL biomarker. Our study
      indicates the biological functions of circRNAs in the development and treatment
      of APL, and provides a comprehensive circRNA resource for future studies.

PMID- 29844436
TI  - Enhanced magnetocaloric effect in Ni-Mn-Sn-Co alloys with two successive
      magnetostructural transformations.
AB  - High magnetocaloric refrigeration performance requires large magnetic entropy
      change DeltaS M and broad working temperature span DeltaT FWHM . A fourth element
      doping of Co in ternary Ni-Mn-Sn alloy may significantly enhance the saturation
      magnetization of the alloy and thus enhance the DeltaS M . Here, the effects of
      Co-doping on the martensite transformation, magnetic properties and
      magnetocaloric effects (MCE) of quaternary Ni47-xMn43Sn10Cox (x = 0, 6, 11)
      alloys were investigated. The martensite transformation temperatures decrease
      while austenite Curie point increases with Co content increasing to x = 6 and 11,
      thus broadening the temperature window for a high magnetization austenite (13.5,
      91.7 and 109.1 A.m2/kg for x = 0, 6 and 11, respectively). Two successive
      magnetostructural transformations (A -> 10 M and A -> 10 M + 6 M) occur in the
      alloy x = 6, which are responsible for the giant magnetic entropy change DeltaS M
      =  29.5 J/kg.K, wide working temperature span DeltaT FWHM  = 14 K and large
      effective refrigeration capacity RC eff  = 232 J/kg under a magnetic field of 5.0
      T. These results suggest that Ni40.6Mn43.3Sn10.0Co6.1 alloy may act as a
      potential solid-state magnetic refrigerant working at room temperature.

PMID- 29844437
TI  - Extended investigation of tube-gel sample preparation: a versatile and simple
      choice for high throughput quantitative proteomics.
AB  - Sample preparation for quantitative proteomics is a crucial step to ensure the
      repeatability and the accuracy of the results. However, there is no universal
      method compatible with the wide variety of protein extraction buffers currently
      used. We have recently demonstrated the compatibility of tube-gel with SDS-based
      buffers and its efficiency for label-free quantitative proteomics by comparing it
      to stacking gel and liquid digestion. Here, we investigated the compatibility of
      tube-gel with alternatives to SDS-based buffers allowing notably the extraction
      of proteins in various pH conditions. We also explored the use of
      photopolymerization to extend the number of possibilities, as it is compatible
      with a wide range of pH and is non-oxidative. To achieve this goal, we compared
      six extraction buffers in combination with two polymerization conditions to
      further optimize the tube-gel protocol and evaluate its versatility.
      Identification and quantitative results demonstrated the compatibility of tube
      gel with all tested conditions by overall raising quite comparable results. In
      conclusion, tube-gel is a versatile and simple sample preparation method for
      large-scale quantitative proteomics applications. Complete datasets are available
      via ProteomeXchange with identifier PXD008656.

PMID- 29844438
TI  - Association of a rare variant of the TNFSF13B gene with susceptibility to
      Rheumatoid Arthritis and Systemic Lupus Erythematosus.
AB  - A rare variant (BAFF-var) of the tumor necrosis factor superfamily 13b (TNFSF13B)
      gene has been recently associated with multiple sclerosis (MS) and systemic lupus
      erythematosus (SLE). The aim of this study was to investigate the association
      between TNFSF13B BAFF-var and susceptibility to rheumatoid arthritis (RA) and
      replicate that association in SLE. 6,218 RA patients, 2,575 SLE patients and
      4,403 healthy controls from three different countries were included in the study.
      TNFSF13B BAFF-var was genotyped using TaqMan allelic discrimination assay. PLINK
      software was used for statistical analyses. TNFSF13B BAFF-var was significantly
      associated with RA (p = 0.015, OR = 1.21, 95% CI = 1.03-1.41) in the Spanish
      cohort. A trend of association was observed in the Dutch (p = 0.115) and German
      (p = 0.228) RA cohorts. A meta-analysis of the three RA cohorts included in this
      study revealed a statistically significant association (p = 0.002, OR = 1.24, 95%
      CI = 1.10-1.38). In addition, TNFSF13B BAFF-var was significantly associated with
      SLE in the Spanish (p = 0.001, OR = 1.41, 95% CI = 1.14-1.74) and the German
      cohorts (p = 0.030, OR = 1.86, 95% CI = 1.05-3.28), with a statistically
      significant p-value obtained in the meta-analysis (p = 0.0002, OR = 1.46, 95% CI
      = 1.09-2.32). The results obtained confirm the known association of TNFSF13B BAFF
      var with SLE and, for the first time, demonstrate that this variant contributes
      to susceptibility to RA.

PMID- 29844439
TI  - Analytical and toxicological evaluation of flavor chemicals in electronic
      cigarette refill fluids.
AB  - Thousands of electronic cigarette refill fluids are commercially available. The
      concentrations of nicotine and the solvents, but not the flavor chemicals, are
      often disclosed on product labels. The purpose of this study was to identify and
      quantify flavor chemicals in 39 commercial refill fluids that were previously
      evaluated for toxicity. Twelve flavor chemicals were identified with
      concentrations >=1 mg/ml: cinnamaldehyde, menthol, benzyl alcohol, vanillin,
      eugenol, p-anisaldehyde, ethyl cinnamate, maltol, ethyl maltol, triacetin,
      benzaldehyde, and menthone. Transfer of these flavor chemicals into aerosols made
      at 3V and 5V was efficient (mean transfer = 98%). We produced lab-made refill
      fluids containing authentic standards of each flavor chemical and analyzed the
      toxicity of their aerosols produced at 3V and 5V using a tank Box Mod device.
      Over 50% of the refill fluids in our sample contained high concentrations of
      flavor chemicals that transferred efficiently to aerosols at concentrations that
      produce cytotoxicity. When tested with two types of human lung cells, the
      aerosols made at 5V were generally more toxic than those made at 3V. These data
      will be valuable for consumers, physicians, public health officials, and
      regulatory agencies when discussing potential health concerns relating to flavor
      chemicals in electronic cigarette products.

PMID- 29844440
TI  - Resolving the smell of wood - identification of odour-active compounds in Scots
      pine (Pinus sylvestris L.).
AB  - Being one of the most common trees in forests, Pinus sylvestris L. is a
      frequently used raw material for wood products. Its specific odour is, however,
      mostly unresolved to date. Accordingly, we investigated Scots pine wood samples
      grown in Germany for their main odorant composition. We employed dedicated
      odorant analysis techniques such as gas chromatography-olfactometry (GC-O) and
      aroma extract dilution analysis (AEDA) and successfully detected 44 odour-active
      compounds; of these, 39 substances were successfully identified by gas
      chromatography-mass spectrometry/olfactometry (GC-MS/O) and two-dimensional gas
      chromatography-mass spectrometry/olfactometry (2D-GC-MS/O). Among the main
      odorants found were (E,E)-nona-2,4-dienal, vanillin, phenylacetic acid, 3
      phenylpropanoic acid, delta-octalactone and alpha-pinene, all of them having been
      detected with high flavour dilution factors during GC-O analyses. The majority of
      the identified odorants were fatty acid degradation products, plus some terpenoic
      substances and odorous substances resulting from the degradation of lignin.
      Although some of the detected substances have previously been reported as
      constituents of wood, 11 substances are reported here for the first time as odour
      active compounds in wood, amongst them heptanoic acid, gamma-octalactone, delta
      nonalactone and (E,Z,Z)-trideca-2,4,7-trienal.

PMID- 29844441
TI  - Association of assisted reproductive technology and multiple pregnancies with the
      risks of birth defects and stillbirth: A retrospective cohort study.
AB  - Assisted reproductive technology (ART) has been widely used among women with
      infertility. However, the association of ART with birth defects and stillbirth
      remains controversial and has rarely been reported in China. A retrospective
      cohort study of 112,043 pregnant women and 114,522 newborns from 2006 to 2016 was
      performed. Compared to spontaneously conceived infants, ART-conceived infants had
      a higher likelihood of any birth defect, with an adjusted odds ratio (OR) of 2.10
      (95% confidence interval, 1.63-2.69). ART-conceived infants also had a
      significantly increased risk for subcategories of cardiovascular,
      musculoskeletal, urogenital, gastrointestinal, and respiratory defects. Most
      (62.25%) of the effect of ART on birth defects was a direct effect, whereas
      37.75% of the effect of ART on birth defects was due to multiple pregnancies
      (i.e., an indirect effect). Compared with naturally conceived singletons, the
      combined effect of ART and twins on the risk of birth defects was lower than that
      of the sum of the individual effects of ART and twins on the risk of birth
      defects, with an adjusted OR of 0.54 (0.32-0.92). These findings clearly show
      that ART is associated with an increased risk of birth defects in China and may
      provide guidance to couples and obstetricians in selecting numbers of pregnancies
      and in identifying organs at a high risk of birth defects.

PMID- 29844442
TI  - Author Correction: The atopic dermatitis blood signature is characterized by
      increases in inflammatory and cardiovascular risk proteins.
AB  - A correction to this article has been published and is linked from the HTML and
      PDF versions of this paper. The error has been fixed in the paper.

PMID- 29844443
TI  - The Evolution of Molecular Compatibility between Bacteriophage PhiX174 and its
      Host.
AB  - Viruses rely upon their hosts for biosynthesis of viral RNA, DNA and protein.
      This dependency frequently engenders strong selection for virus genome
      compatibility with potential hosts, appropriate gene regulation and expression
      necessary for a successful infection. While bioinformatic studies have shown
      strong correlations between codon usage in viral and host genomes, the selective
      factors by which this compatibility evolves remain a matter of conjecture.
      Engineered to include codons with a lesser usage and/or tRNA abundance within the
      host, three different attenuated strains of the bacterial virus FX174 were
      created and propagated via serial transfers. Molecular sequence data indicate
      that biosynthetic compatibility was recovered rapidly. Extensive computational
      simulations were performed to assess the role of mutational biases as well as
      selection for translational efficiency in the engineered phage. Using
      bacteriophage as a model system, we can begin to unravel the evolutionary
      processes shaping codon compatibility between viruses and their host.

PMID- 29844444
TI  - Dominant-negative STAT5B mutations cause growth hormone insensitivity with short
      stature and mild immune dysregulation.
AB  - Growth hormone (GH) insensitivity syndrome (GHIS) is a rare clinical condition in
      which production of insulin-like growth factor 1 is blunted and, consequently,
      postnatal growth impaired. Autosomal-recessive mutations in signal transducer and
      activator of transcription (STAT5B), the key signal transducer for GH, cause
      severe GHIS with additional characteristics of immune and, often fatal, pulmonary
      complications. Here we report dominant-negative, inactivating STAT5B germline
      mutations in patients with growth failure, eczema, and elevated IgE but without
      severe immune and pulmonary problems. These STAT5B missense mutants are robustly
      tyrosine phosphorylated upon stimulation, but are unable to nuclear localize, or
      fail to bind canonical STAT5B DNA response elements. Importantly, each variant
      retains the ability to dimerize with wild-type STAT5B, disrupting the normal
      transcriptional functions of wild-type STAT5B. We conclude that these STAT5B
      variants exert dominant-negative effects through distinct pathomechanisms,
      manifesting in milder clinical GHIS with general sparing of the immune system.

PMID- 29844445
TI  - Dexamethasone-induced Intra-Uterine Growth Restriction impacts NOSTRIN and its
      downstream effector genes in the rat mesometrial uterus.
AB  - Intra-Uterine Growth Restriction (IUGR) is a major cause of fetal and neonatal
      mortality. Understanding the impact of IUGR on utero-placental gene expression is
      key to developing effective therapy. In this report we elucidated the impact of
      IUGR on NOSTRIN and its downstream effector gene expression in the utero
      placental compartments. We showed here that induction of IUGR by maternal
      dexamethasone administration in rats led to up-regulation of NOSTRIN transcript
      and protein in the mesometrial triangle of the uterus (MG) and not in other utero
      placental compartments as compared to control. This was associated with down
      regulation of twelve genes and four cytokines that were known to be regulated by
      NOSTRIN and also required for maintenance of pregnancy. Interestingly, there was
      remarkable decrease in phosphorylation of RelA transcription factor in the MG
      during IUGR in line with the fact that the down regulated genes harbour RelA
      transcription activation domain in their promoters. Furthermore, HIF-1alpha level
      was reciprocal to NOSTRIN expression pattern in the mesometrial compartment
      during IUGR and also in CoCl2 treated endothelial cells. Over-expression of HIF
      1alpha led to a decrease in NOSTRIN levels suggesting inhibition of Nostrin
      transcription by HIF-1alpha. Our findings highlight the importance of NOSTRIN in
      uterine pathophysiology during IUGR.

PMID- 29844446
TI  - The effect of PTC124 on choroideremia fibroblasts and iPSC-derived RPE raises
      considerations for therapy.
AB  - Inherited retinal dystrophies (IRDs) are caused by mutations in over 200 genes,
      resulting in a range of therapeutic options. Translational read-through inducing
      drugs (TRIDs) offer the possibility of treating multiple IRDs regardless of the
      causative gene. TRIDs promote ribosomal misreading of premature stop codons,
      which results in the incorporation of a near-cognate amino acid to produce a full
      length protein. The IRD choroideremia (CHM) is a pertinent candidate for TRID
      therapy, as nonsense variants cause 30% of cases. Recently, treatment of the UAA
      nonsense-carrying CHM zebrafish model with the TRID PTC124 corrected the
      underlying biochemical defect and improved retinal phenotype. To be clinically
      relevant, we studied PTC124 efficiency in UAA nonsense-carrying human fibroblasts
      and induced pluripotent stem cell-derived retinal pigment epithelium, as well as
      in a UAA-mutated CHM overexpression system. We showed that PTC124 treatment
      induces a non-significant trend for functional rescue, which could not be
      improved by nonsense-mediated decay inhibition. Furthermore, it does not produce
      a detectable CHM-encoded protein even when coupled with a proteasome inhibitor.
      We suggest that drug efficiency may depend upon on the target amino acid and its
      evolutionary conservation, and argue that patient cells should be screened in
      vitro prior to inclusion in a clinical trial.

PMID- 29844447
TI  - Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response
      in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation.
AB  - Homoharringtonine (HHT), an inhibitor of protein synthesis, has been used to
      treat leukemia. Its therapeutic effects on non-small cell lung adenocarcinoma
      carrying KRAS mutation and their immune system are less understood. The present
      study examined the therapeutic efficacy and the immune effects of HHT in two
      murine lung tumor models, xenograft and transgenic, carrying the Kras mutation
      G12D and G12C respectively. HHT exhibited efficient anticancer activity,
      significantly suppressing lung tumor growth in vitro and in vivo. The levels of
      22 cytokines and chemokines in splenocytes of tumor-bearing mice were examined.
      Interleukin-12 expression was lower in splenocytes of HHT-treated mice when
      compared to the controls as demonstrated by a cytokine array and an enzyme-linked
      immunosorbent assay. The expression levels of CD80, CD86, and CD69 in B220+ B
      cells from splenocytes of HHT-treated mice were higher than that of control mice
      in two mouse tumor models. Furthermore, antitumor effect of HHT was attenuated
      with depletion of B cells. Increased numbers of CD80+ and CD86+ B cells were
      observed in the mice treated with narciclasine, another translation inhibitor. In
      conclusion, HHT changed the features of immune cells, and exhibited efficient
      anti-tumor activity against lung tumor carrying mutant Kras expression.

PMID- 29844448
TI  - Sonochemical synthesis of cellulose/hydroxyapatite nanocomposites and their
      application in protein adsorption.
AB  - Hydroxyapatite (HA) is the main mineral constituent in the hard tissue of
      vertebrate, which is recognized as an important biomedical material owing to its
      excellent bioactivity and biocompatibility. Herein, we report a facile and green
      sonochemical route for the rapid synthesis of cellulose/HA nanocomposites in
      NaOH/urea aqueous solution. The in vitro behavior of the cellulose/HA
      nanocomposites was studied to evaluate the biological response of the
      nanocomposites following immersion in simulated body fluid for various periods
      (maximum of 28 days). The HA crystals formed on the surface of the nanocomposites
      were carbonate-containing apatite, which is similar to the naturally occurring
      calcium phosphate materials. The HA nanosheets (assembly of nanorods) were
      mineralized on the surface of the nanocomposites, and maximum mass of the
      nanocomposites was reached 1.82 times of initial mass after 28 days of soaking.
      Moreover, the as-prepared cellulose/HA nanocomposites have good
      cytocompatibility, and show a relatively high protein adsorption ability using
      hemoglobin as a model protein. These results indicate that the as-prepared
      cellulose/HA nanocomposites are promising for applications in various biomedical
      fields such as tissue engineering and protein/drug delivery.

PMID- 29844449
TI  - Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?
AB  - Leucine-rich repeat-containing G-protein coupled receptor (LGR5 or GPR49)
      potentiates canonical Wnt/beta-catenin signalling and is a marker of normal stem
      cells in several tissues, including the intestine. Consistent with stem cell
      potential, single isolated LGR5+ cells from the gut generate self-organising
      crypt/villus structures in vitro termed organoids or 'mini-guts', which
      accurately model the parent tissue. The well characterised deregulation of
      Wnt/beta-catenin signalling that occurs during the adenoma-carcinoma sequence in
      colorectal cancer (CRC) renders LGR5 an interesting therapeutic target.
      Furthermore, recent studies demonstrating that CRC tumours contain LGR5+ subsets
      and retain a degree of normal tissue architecture has heightened translational
      interest. Such reports fuel hope that specific subpopulations or molecules within
      a tumour may be therapeutically targeted to prevent relapse and induce long-term
      remissions. Despite these observations, many studies within this field have
      produced conflicting and confusing results with no clear consensus on the
      therapeutic value of LGR5. This review will recap the various oncogenic and
      tumour suppressive roles that have been described for the LGR5 molecule in CRC.
      It will further highlight recent studies indicating the plasticity or redundancy
      of LGR5+ cells in intestinal cancer progression and assess the overall merit of
      therapeutically targeting LGR5 in CRC.

PMID- 29844450
TI  - Oleuropein aglycone stabilizes the monomeric alpha-synuclein and favours the
      growth of non-toxic aggregates.
AB  - alpha-synuclein plays a key role in the pathogenesis of Parkinson's disease (PD);
      its deposits are found as amyloid fibrils in Lewy bodies and Lewy neurites, the
      histopathological hallmarks of PD. Amyloid fibrillation is a progressive
      polymerization path starting from peptide/protein misfolding and proceeding
      through the transient growth of oligomeric intermediates widely considered as the
      most toxic species. Consequently, a promising approach of intervention against PD
      might be preventing alpha-synuclein build-up, misfolding and aggregation. A
      possible strategy involves the use of small molecules able to slow down the
      aggregation process or to alter oligomer conformation favouring the growth of non
      pathogenic species. Here, we show that oleuropein aglycone (OleA), the main olive
      oil polyphenol, exhibits anti-amyloidogenic power in vitro by interacting with,
      and stabilizing, alpha-synuclein monomers thus hampering the growth of on-pathway
      oligomers and favouring the growth of stable and harmless aggregates with no
      tendency to evolve into other cytotoxic amyloids. We investigated the molecular
      basis of such interference by both biophysical techniques and limited
      proteolysis; aggregate morphology was monitored by electron microscopy. We also
      found that OleA reduces the cytotoxicity of alpha-synuclein aggregates by
      hindering their binding to cell membrane components and preventing the resulting
      oxidative damage to cells.

PMID- 29844451
TI  - Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice.
AB  - Activation of TLR2 or TLR4 by endogenous ligands such as high mobility group box
      1 (HMGB1) may mediate inflammation causing diabetic kidney injury. We determined
      whether blockade of HMGB1 signaling by: (1) supra-physiological production of
      endogenous secretory Receptor for Advanced Glycation End-products (esRAGE), a
      receptor for HMGB1; (2) administration of HMGB1 A Box, a specific competitive
      antagonist, would inhibit development of streptozotocin induced diabetic
      nephropathy (DN). Wild-type diabetic mice developed albuminuria, glomerular
      injuries, interstitial fibrosis and renal inflammation. Using an adeno-associated
      virus vector, systemic over-expression of esRAGE afforded significant protection
      from all parameters. No protection was achieved by a control vector which
      expressed human serum albumin. Administration of A Box was similarly protective
      against development of DN. To determine the mechanism(s) of protection, we found
      that whilst deficiency of TLR2, TLR4 or RAGE afforded partial protection from
      development of DN, over-expression of esRAGE provided additional protection in
      TLR2-/-, modest protection against podocyte damage only in TLR4-/- and no
      protection in RAGE-/- diabetic mice, suggesting the protection provided by esRAGE
      was primarily through interruption of RAGE and TLR4 pathways. We conclude that
      strategies to block the interaction between HMGB1 and its receptors may be
      effective in preventing the development of DN.

PMID- 29844453
TI  - Genotype by Yield*Trait (GYT) Biplot: a Novel Approach for Genotype Selection
      based on Multiple Traits.
AB  - Genotype selection based on multiple traits is a key issue in plant breeding; it
      has been dependent on setting a subjective weight for each trait in index
      selection and a subjective truncation point for each trait in independent
      culling, and the weights and truncation points can be highly subjective. In this
      paper we proposed and demonstrated a novel approach for genotype selection based
      on multiple traits, the genotype by yield*trait (GYT) biplot, where "trait" can
      be any breeding objective other than yield; it may be an agronomic trait, a grain
      quality, processing quality, or nutritional quality trait, or a disease
      resistance. The GYT biplot ranks genotypes based on their levels in combining
      yield with other target traits and at the same time shows their trait profiles,
      i.e., their strengths and weaknesses. Compared to existing methods, this approach
      is graphical, objective, effective, and straightforward. Underlying the GYT
      biplot approach is the paradigm shift that genotypes should be evaluated by their
      levels in combining yield with other traits as opposed to by their levels in
      individual traits. An oat dataset from multi-year multi-locations trials was used
      to demonstrate the GYT biplot approach.

PMID- 29844452
TI  - Linking spatial gene expression patterns to sex-specific brain structural changes
      on a mouse model of 16p11.2 hemideletion.
AB  - Neurodevelopmental disorders, such as ASD and ADHD, affect males about three to
      four times more often than females. 16p11.2 hemideletion is a copy number
      variation that is highly associated with neurodevelopmental disorders. Previous
      work from our lab has shown that a mouse model of 16p11.2 hemideletion (del/+)
      exhibits male-specific behavioral phenotypes. We, therefore, aimed to investigate
      with magnetic resonance imaging (MRI), whether del/+ animals also exhibited a sex
      specific neuroanatomical endophenotype. Using the Allen Mouse Brain Atlas, we
      analyzed the expression patterns of the 27 genes within the 16p11.2 region to
      identify which gene expression patterns spatially overlapped with brain
      structural changes. MRI was performed ex vivo and the resulting images were
      analyzed using Voxel-based morphometry for T1-weighted sequences and tract-based
      spatial statistics for diffusion-weighted images. In a subsequent step, all
      available in situ hybridization (ISH) maps of the genes involved in the 16p11.2
      hemideletion were aligned to Waxholm space and clusters obtained by sex-specific
      group comparisons were analyzed to determine which gene(s) showed the highest
      expression in these regions. We found pronounced sex-specific changes in male
      animals with increased fractional anisotropy in medial fiber tracts, especially
      in those proximate to the striatum. Moreover, we were able to identify gene
      expression patterns spatially overlapping with male-specific structural changes
      that were associated with neurite outgrowth and the MAPK pathway. Of note,
      previous molecular studies have found convergent changes that point to a sex
      specific dysregulation of MAPK signaling. This convergent evidence supports the
      idea that ISH maps can be used to meaningfully analyze imaging data sets.

PMID- 29844454
TI  - Self-assembly, optical and electrical properties of perylene diimide dyes bearing
      unsymmetrical substituents at bay position.
AB  - Perylene diimides (PDIs) are one class of the most explored organic fluorescent
      materials due to their high luminescence efficiency, optoelectronic properties,
      and ready to form well-tailored supramolecular structures. However, heavy
      aggregation caused quenching (ACQ) effect in solid state has greatly limited
      their potential applications. We have easily solved this problem by chemical
      modification of the PDI core with only phenoxy moietie at one of the bay
      position. In this paper, we report two perylene bisimides with small rigid
      substituents, 1- phenol -N, N'-dicyclohexyl perylene-3,4,9,10-tetracarboxylic
      diimide (PDI 1) and 1- p-chlorophenol-N, N'-dicyclohexyl perylene-3,4,9,10
      tetracarboxylic diimide (PDI 2) possess both well defined organic nanostructures
      and high fluorescence quantum yield in the solid state. In contrast, 1-propanol
      N, N'-dicyclohexyl perylene-3,4,9,10-tetracarboxylic diimide (PDI 3) bearing a
      straight chain only shown weak orange fluorescence. In addition, morphological
      inspection demonstrated that PDI 3 molecules easily form well-organized
      microstructures despite the linkage of the PDI core with a straight chain. The
      present strategy could provide a generic route towards novel and advanced
      fluorescent materials and these materials may find various applications in high
      tech fields.

PMID- 29844455
TI  - Oligomeric states of microbial rhodopsins determined by high-speed atomic force
      microscopy and circular dichroic spectroscopy.
AB  - Oligomeric assembly is a common feature of membrane proteins and often relevant
      to their physiological functions. Determining the stoichiometry and the
      oligomeric state of membrane proteins in a lipid bilayer is generally challenging
      because of their large size, complexity, and structural alterations under
      experimental conditions. Here, we use high-speed atomic force microscopy (HS-AFM)
      to directly observe the oligomeric states in the lipid membrane of various
      microbial rhodopsins found within eubacteria to archaea. HS-AFM images show that
      eubacterial rhodopsins predominantly exist as pentamer forms, while archaeal
      rhodopsins are trimers in the lipid membrane. In addition, circular dichroism
      (CD) spectroscopy reveals that pentameric rhodopsins display inverted CD couplets
      compared to those of trimeric rhodopsins, indicating different types of exciton
      coupling of the retinal chromophore in each oligomer. The results clearly
      demonstrate that the stoichiometry of the fundamental oligomer of microbial
      rhodopsins strongly correlate with the phylogenetic tree, providing a new insight
      into the relationship between the oligomeric structure and function-structural
      evolution of microbial rhodopsins.

PMID- 29844456
TI  - Exploration of an urban lake management model to simulate chlorine interference
      based on the ecological relationships among aquatic species.
AB  - In eutrophic lakes, algae are known to be sensitive to chlorine, but the impact
      of chlorine on the wider ecosystem has not been investigated. To quantitatively
      investigate the effects of chlorine on the urban lake ecosystem and analyze the
      changes in the aquatic ecosystem structure, a dynamic response model of aquatic
      species to chlorine was constructed based on the biomass density dynamics of
      aquatic species of submerged macrophytes, phytoplankton, zooplankton, periphyton,
      and benthos. The parameters were calibrated using data from the literature and
      two simulative experiments. The model was then validated using field data from an
      urban lake with a surface area of approximately 8000 m2 located in the downtown
      area of Guangzhou, South China. The correlation coefficient (R), root mean square
      error-observations standard deviation ratio (RSR) and index of agreement (IOA)
      were used to evaluate the accuracy and reliability of the model and the results
      were consistent with the observations (0.446 R < 0.985, RSR < 0.7, IOA > 0.6).
      Comparisons between the simulated and observed trends confirmed the feasibility
      of using this model to investigate the dynamics of aquatic species under chlorine
      interference. The model can help managers apply a modest amount of chlorine to
      control eutrophication and provides scientific support for the management of
      urban lakes.

PMID- 29844457
TI  - Outer Membrane Vesicles from Neisseria Meningitidis (Proteossome) Used for
      Nanostructured Zika Virus Vaccine Production.
AB  - The increase of Zika virus (ZIKV) infections in Brazil in the last two years
      leaves a prophylactic measures on alert for this new and emerging pathogen.
      Concerning of our positive experience, we developed a new prototype using
      Neisseria meningitidis outer membrane vesicles (OMV) on ZIKV cell growth in a
      fusion of OMV in the envelope of virus particles. The fusion of nanoparticles
      resulting from outer membrane vesicles of N. meningitidis with infected C6/36
      cells line were analyzed by Nano tracking analysis (NTA), zeta potential,
      differential light scattering (DLS), scan and scanning transmission eletronic
      microscopy (SEM and STEM) and high resolution mass spectometry (HRMS) for
      nanostructure characterization. Also, the vaccination effects were viewed by
      immune response in mice protocols immunization (ELISA and inflammatory
      chemokines) confirmed by Zika virus soroneutralization test. The results of
      immunizations in mice showed that antibody production had a titer greater than
      1:160 as compared to unvaccinated mice. The immune response of the adjuvant and
      non-adjuvant formulation activated the cellular immune response TH1 and TH2. In
      addition, the serum neutralization was able to prevent infection of virus
      particles in the glial tumor cell model (M059J). This research shows efficient
      strategies without recombinant technology or DNA vaccines.

PMID- 29844458
TI  - Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency.
AB  - Genome editing is the introduction of directed modifications in the genome, a
      process boosted to therapeutic levels by designer nucleases. Building on the
      experience of ex vivo gene therapy for severe combined immunodeficiencies, it is
      likely that genome editing of haematopoietic stem/progenitor cells (HSPC) for
      correction of inherited blood diseases will be an early clinical application. We
      show molecular evidence of gene correction in a mouse model of primary
      immunodeficiency. In vitro experiments in DNA-dependent protein kinase catalytic
      subunit severe combined immunodeficiency (Prkdc scid) fibroblasts using designed
      zinc finger nucleases (ZFN) and a repair template demonstrated molecular and
      functional correction of the defect. Following transplantation of ex vivo gene
      edited Prkdc scid HSPC, some of the recipient animals carried the expected
      genomic signature of ZFN-driven gene correction. In some primary and secondary
      transplant recipients we detected double-positive CD4/CD8 T-cells in thymus and
      single-positive T-cells in blood, but no other evidence of immune reconstitution.
      However, the leakiness of this model is a confounding factor for the
      interpretation of the possible T-cell reconstitution. Our results provide support
      for the feasibility of rescuing inherited blood disease by ex vivo genome editing
      followed by transplantation, and highlight some of the challenges.

PMID- 29844459
TI  - The effect of N-acetyl-l-cysteine (NAC) on liver toxicity and clinical outcome
      after hematopoietic stem cell transplantation.
AB  - : Busulphan (Bu) is a myeloablative drug used for conditioning prior to
      hematopoietic stem cell transplantation. Bu is predominantly metabolized through
      glutathione conjugation, a reaction that consumes the hepatic glutathione. N
      acetyl-l-cysteine (NAC) is a glutathione precursor used in the treatment of
      acetaminophen hepatotoxicity. NAC does not interfere with the busulphan
      myeloablative effect. We investigated the effect of NAC concomitant treatment
      during busulphan conditioning on the liver enzymes as well as the clinical
      outcome. Prophylactic NAC treatment was given to 54 patients upon the start of
      busulphan conditioning. These patients were compared with 54 historical matched
      controls who did not receive NAC treatment. In patients treated with NAC,
      aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase
      (ALP) were significantly (P < 0.05) decreased after conditioning compared to
      their start values. Within the NAC-group, liver enzymes were normalized in those
      patients (30%) who had significantly high start values. No significant decrease
      in enzyme levels was observed in the control group. Furthermore, NAC affected
      neither Bu kinetics nor clinical outcome (sinusoidal obstruction syndrome
      incidence, graft-versus-host disease and/or graft failure). IN CONCLUSION: NAC is
      a potential prophylactic treatment for hepatotoxicity during busulphan
      conditioning. NAC therapy did not alter busulphan kinetics or affect clinical
      outcome.

PMID- 29844460
TI  - Spatially organizing biochemistry: choosing a strategy to translate synthetic
      biology to the factory.
AB  - Natural biochemical systems are ubiquitously organized both in space and time.
      Engineering the spatial organization of biochemistry has emerged as a key theme
      of synthetic biology, with numerous technologies promising improved biosynthetic
      pathway performance. One strategy, however, may produce disparate results for
      different biosynthetic pathways. We use a spatially resolved kinetic model to
      explore this fundamental design choice in systems and synthetic biology. We
      predict that two example biosynthetic pathways have distinct optimal organization
      strategies that vary based on pathway-dependent and cell-extrinsic factors.
      Moreover, we demonstrate that the optimal design varies as a function of kinetic
      and biophysical properties, as well as culture conditions. Our results suggest
      that organizing biosynthesis has the potential to substantially improve
      performance, but that choosing the appropriate strategy is key. The flexible
      design-space analysis we propose can be adapted to diverse biosynthetic pathways,
      and lays a foundation to rationally choose organization strategies for
      biosynthesis.

PMID- 29844461
TI  - Exploring the Reusability of Synthetically Contaminated Wastewater Containing
      Crystal Violet Dye using Tectona grandis Sawdust as a Very Low-Cost Adsorbent.
AB  - Present investigation explores the possible reusability of synthetically
      contaminated wastewater containing crystal violet (CV) organic dye using Tectona
      grandis sawdust (TGSD) waste as a very low-cost adsorbent. The adsorbent was
      characterized by proximate, SEM/EDX, FTIR, and XRD analyses. Batch adsorption
      studies were carried under changing conditions of contact time, the initial
      concentration of CV, pH, TGSD dose, TGSD particle size, and temperature. The
      experimental data were tested using Langmuir, Freundlich and Temkin isotherm
      models, and the data were best followed by Langmuir one. The kinetic results were
      examined in the light of different models and pseudo-second-order was obtained to
      be best obeyed. The values of DeltaH degrees  (28.642 kJ/mol), DeltaG degrees  (
      10.776 to -7.080 kJ/mol) and DeltaS degrees  (121.8 J/K/mol) in the temperature
      range of 293-323 K suggested the overall process to be spontaneous, endothermic
      and associated with an increase in randomness. On the basis of experimental
      results and their analyses, it has been established that TGSD is one of the most
      effective adsorbents among those obtained from the domestic, agricultural and
      industrial wastes. Thus this adsorbent can be effectively utilized to make the
      impure wastewater reusable.

PMID- 29844462
TI  - Using genetic markers to unravel the origin of birds converging towards pre
      migratory sites.
AB  - Identifying patterns of individual movements in spatial and temporal scales can
      provide valuable insight into the structure of populations and the dynamics of
      communities and ecosystems. Especially for migrating birds, that can face a
      variety of unfavorable conditions along their journey, resolving movements of
      individuals across their annual cycle is necessary in order to design better
      targeted conservation strategies. Here, we studied the movements of a small
      migratory falcon, the Lesser Kestrel (Falco naumanni), by genetically assigning
      feathers from individuals of unknown origin that concentrate in large roosts
      during the pre-migratory period. Our findings suggest that birds from multiple
      breeding populations in the Central and Eastern Mediterranean region move towards
      two pre-migratory sites in the Balkans, some of them detouring greatly from their
      expected flyways, travelling more than 500 km to reach these sites and prepare
      for the post-nuptial migration. By identifying the origin of individuals using
      the pre-migratory sites, not only we provide a better understanding of the
      possible impact of local threats at these sites on multiple breeding populations
      but also inform the design of effective conservation actions for the species.

PMID- 29844463
TI  - Targeted delivery of fluorogenic peptide aptamers into live microalgae by
      femtosecond laser photoporation at single-cell resolution.
AB  - Microalgae-based metabolic engineering has been proven effective for producing
      valuable substances such as food supplements, pharmaceutical drugs, biodegradable
      plastics, and biofuels in the past decade. The ability to accurately visualize
      and quantify intracellular metabolites in live microalgae is essential for
      efficient metabolic engineering, but remains a major challenge due to the lack of
      characterization methods. Here we demonstrate it by synthesizing fluorogenic
      peptide aptamers with specific binding affinity to a target metabolite and
      delivering them into live microalgae by femtosecond laser photoporation at single
      cell resolution. As a proof-of-principle demonstration of our method, we use it
      to characterize Euglena gracilis, a photosynthetic unicellular motile microalgal
      species, which is capable of producing paramylon (a carbohydrate granule similar
      to starch). Specifically, we synthesize a peptide aptamer containing a paramylon
      binding fluorescent probe, 7-nitrobenzofurazan, and introduce it into E. gracilis
      cells one-by-one by suppressing their mobility with mannitol and transiently
      perforating them with femtosecond laser pulses at 800 nm for photoporation. To
      demonstrate the method's practical utility in metabolic engineering, we perform
      spatially and temporally resolved fluorescence microscopy of single live
      photoporated E. gracilis cells under different culture conditions. Our method
      holds great promise for highly efficient microalgae-based metabolic engineering.

PMID- 29844464
TI  - Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate
      kinase M2 via mTOR-HIF1alpha inhibition.
AB  - Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2
      (PKM2) as its key regulator. Curcumin is an extensively-studied anti-cancer
      compound, however, its role in affecting cancer metabolism remains poorly
      understood. Herein, we show that curcumin inhibits glucose uptake and lactate
      production (Warburg effect) in a variety of cancer cell lines by down-regulating
      PKM2 expression, via inhibition of mTOR-HIF1alpha axis. Stable PKM2 silencing
      revealed that PKM2 is required for Warburg effect and proliferation of cancer
      cells. PKM2 over-expression abrogated the effects of curcumin, demonstrating that
      inhibition of Warburg effect by curcumin is PKM2-mediated. High PKM2 expression
      correlated strongly with poor overall survival in cancer, suggesting the
      requirement of PKM2 in cancer progression. The study unravels novel PKM2-mediated
      inhibitory effect of curcumin on metabolic capacities of cancer cells. To the
      best of our knowledge, this is the first study linking curcumin with PKM2-driven
      cancer glycolysis, thus, providing new perspectives into the mechanism of its
      anticancer activity.

PMID- 29844466
TI  - The quest for identifiability in human functional connectomes.
AB  - The evaluation of the individual "fingerprint" of a human functional connectome
      (FC) is becoming a promising avenue for neuroscientific research, due to its
      enormous potential inherent to drawing single subject inferences from functional
      connectivity profiles. Here we show that the individual fingerprint of a human
      functional connectome can be maximized from a reconstruction procedure based on
      group-wise decomposition in a finite number of brain connectivity modes. We use
      data from the Human Connectome Project to demonstrate that the optimal
      reconstruction of the individual FCs through connectivity eigenmodes maximizes
      subject identifiability across resting-state and all seven tasks evaluated. The
      identifiability of the optimally reconstructed individual connectivity profiles
      increases both at the global and edgewise level, also when the reconstruction is
      imposed on additional functional data of the subjects. Furthermore, reconstructed
      FC data provide more robust associations with task-behavioral measurements.
      Finally, we extend this approach to also map the most task-sensitive functional
      connections. Results show that is possible to maximize individual fingerprinting
      in the functional connectivity domain regardless of the task, a crucial next step
      in the area of brain connectivity towards individualized connectomics.

PMID- 29844465
TI  - Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans
      Promote Mitochondrial Maintenance and Protect Against Chemical-Induced
      Mitotoxicity.
AB  - Exercise and caloric restriction improve health, including reducing risk of
      cardiovascular disease, neurological disease, and cancer. However, molecular
      mechanisms underlying these protections are poorly understood, partly due to the
      cost and time investment of mammalian long-term diet and exercise intervention
      studies. We subjected Caenorhabditis elegans nematodes to a 6-day, twice daily
      swimming exercise regimen, during which time the animals also experienced brief,
      transient food deprivation. Accordingly, we included a non-exercise group with
      the same transient food deprivation, a non-exercise control with ad libitum
      access to food, and a group that exercised in food-containing medium. Following
      these regimens, we assessed mitochondrial health and sensitivity to mitochondrial
      toxicants. Exercise protected against age-related decline in mitochondrial
      morphology in body-wall muscle. Food deprivation increased organismal basal
      respiration; however, exercise was the sole intervention that increased spare
      respiratory capacity and proton leak. We observed increased lifespan in exercised
      animals compared to both control and transiently food-deprived nematodes.
      Finally, exercised animals (and to a lesser extent, transiently food-deprived
      animals) were markedly protected against lethality from acute exposures to the
      mitotoxicants rotenone and arsenic. Thus, swimming exercise and brief food
      deprivation provide effective intervention in C. elegans, protecting from age
      associated mitochondrial decline and providing resistance to mitotoxicant
      exposures.

PMID- 29844467
TI  - Mitophagy is required for brown adipose tissue mitochondrial homeostasis during
      cold challenge.
AB  - Brown adipose tissue (BAT) is a specialized thermogenic organ in mammals. The
      ability of BAT mitochondria to generate heat in response to cold-challenge to
      maintain core body temperature is essential for organismal survival. While cold
      activated BAT mitochondrial biogenesis is recognized as critical for thermogenic
      adaptation, the contribution of mitochondrial quality control to this process
      remains unclear. Here, we show mitophagy is required for brown adipocyte
      mitochondrial homeostasis during thermogenic adaptation. Mitophagy is
      significantly increased in BAT from cold-challenged mice (4  degrees C) and in
      beta-agonist treated brown adipocytes. Blockade of mitophagy compromises brown
      adipocytes mitochondrial oxidative phosphorylation (OX-PHOS) capacity, as well as
      BAT mitochondrial integrity. Mechanistically, cold-challenge induction of BAT
      mitophagy is UCP1-dependent. Furthermore, our results indicate that mitophagy
      coordinates with mitochondrial biogenesis, maintaining activated BAT
      mitochondrial homeostasis. Collectively, our in vivo and in vitro findings
      identify mitophagy as critical for brown adipocyte mitochondrial homeostasis
      during cold adaptation.

PMID- 29844468
TI  - Spatial and temporal changes in extracellular elastin and laminin distribution
      during lung alveolar development.
AB  - Lung alveolarization requires precise coordination of cell growth with
      extracellular matrix (ECM) synthesis and deposition. The role of extracellular
      matrices in alveogenesis is not fully understood, because prior knowledge is
      largely extrapolated from two-dimensional structural analysis. Herein, we studied
      temporospatial changes of two important ECM proteins, laminin and elastin that
      are tightly associated with alveolar capillary growth and lung elastic recoil
      respectively, during both mouse and human lung alveolarization. By combining
      protein immunofluorescence staining with two- and three-dimensional imaging, we
      found that the laminin network was simplified along with the thinning of septal
      walls during alveogenesis, and more tightly associated with alveolar endothelial
      cells in matured lung. In contrast, elastin fibers were initially localized to
      the saccular openings of nascent alveoli, forming a ring-like structure. Then,
      throughout alveolar growth, the number of such alveolar mouth ring-like
      structures increased, while the relative ring size decreased. These rings were
      interconnected via additional elastin fibers. The apparent patches and dots of
      elastin at the tips of alveolar septae found in two-dimensional images were cross
      sections of elastin ring fibers in the three-dimension. Thus, the previous
      concept that deposition of elastin at alveolar tips drives septal inward growth
      may potentially be conceptually challenged by our data.

PMID- 29844469
TI  - Ultrasound-Mediated EGF-Coated-Microbubble Cavitation in Dressings for Wound
      Healing Applications.
AB  - The feasibility of ultrasound (US) controlled cavitation for transdermal drug
      delivery (TDD) using gas-filled microbubbles (MBs) has been explored. However,
      liquid or gel-type MBs is not easy used for TDD. The present study investigated a
      new treatment model for evaluating the US-mediated liquid-type epidermal growth
      factor (EGF)-coated lysozyme microbubble (LYMB) cavitation in a wound dressing
      for enhancing wound healing. The maximum loading efficacy of EGF onto LYMBs was
      19.40 +/- 0.04%. In terms of the in vitro treatment efficacy, the growth of
      Staphylococcus aureus was inhibited by 97.50 +/- 1.50% in the group with LYMBs
      exposed to 3 W/cm2 US. During 21 days in vivo wound healing experiments, the
      recovery rate during the first 6 days was significant higher in the group with
      EGF-LYMB dressings and US exposure (day 6: 54.28 +/- 3.26%) than in the control
      group (day 6: 26.36 +/- 3.34%) (p < 0.05). Our results show that the new model
      can significantly reduce the treatment duration during wound healing.

PMID- 29844470
TI  - Repeated administration of alpha-galactosylceramide ameliorates experimental
      lupus nephritis in mice.
AB  - Lupus nephritis is a crucial complication of systemic lupus erythematosus. In
      this study, we investigated the roles of mouse natural killer T (NKT) cells in
      lupus nephritis. From 24 weeks of age, NZB/NZW F1 mice were injected with alpha
      galactosylceramide (alpha-GalCer) or vehicle once a week for four weeks. In the
      alpha-GalCer group, the levels of proteinuria and blood urea nitrogen were
      significantly lower than those in the vehicle group. The histological evaluation
      showed a decrease in glomerular immune complex deposits and an alleviation of
      podocyte injury. The proportion of NKT cells in the mononuclear cell (MNC)
      fraction in the alpha-GalCer group was significantly decreased in the liver,
      kidney, and spleen. The proliferation and cytokine production in alpha-GalCer
      stimulated liver MNCs were markedly diminished in the alpha-GalCer group
      (anergy). The IFN-gamma production in liver MNCs stimulated by concanavalin A or
      an anti-CD3 antibody did not differ between the two groups, whereas the IL-4
      production was significantly lower in the alpha-GalCer group. In addition, the
      IgM production in CpG-oligodeoxynucleotide-stimulated spleen MNCs was
      significantly lower in the alpha-GalCer group. These results suggest that alpha
      GalCer suppressed Th2 immune responses in NKT cells and B cell function, thereby
      slowing the progression of lupus nephritis.

PMID- 29844471
TI  - Trends in flood losses in Europe over the past 150 years.
AB  - Adverse consequences of floods change in time and are influenced by both natural
      and socio-economic trends and interactions. In Europe, previous studies of
      historical flood losses corrected for demographic and economic growth
      ('normalized') have been limited in temporal and spatial extent, leading to an
      incomplete representation of trends in losses over time. Here we utilize a
      gridded reconstruction of flood exposure in 37 European countries and a new
      database of damaging floods since 1870. Our results indicate that, after
      correcting for changes in flood exposure, there has been an increase in annually
      inundated area and number of persons affected since 1870, contrasted by a
      substantial decrease in flood fatalities. For more recent decades we also found a
      considerable decline in financial losses per year. We estimate, however, that
      there is large underreporting of smaller floods beyond most recent years, and
      show that underreporting has a substantial impact on observed trends.

PMID- 29844472
TI  - Amending the Structure of Renewable Carbon from Biorefinery Waste-Streams for
      Energy Storage Applications.
AB  - Biorefineries produce impure sugar waste streams that are being underutilized. By
      converting this waste to a profitable by-product, biorefineries could be
      safeguarded against low oil prices. We demonstrate controlled production of
      useful carbon materials from the waste concentrate via hydrothermal synthesis and
      carbonization. We devise a pathway to producing tunable, porous spherical carbon
      materials by modeling the gross structure formation and developing an
      understanding of the pore formation mechanism utilizing simple reaction
      principles. Compared to a simple hydrothermal synthesis from sugar concentrate,
      emulsion-based synthesis results in hollow spheres with abundant microporosity.
      In contrast, conventional hydrothermal synthesis produces solid beads with micro
      and mesoporosity. All the carbonaceous materials show promise in energy storage
      application. Using our reaction pathway, perfect hollow activated carbon spheres
      can be produced from waste sugar in liquid effluence of biomass steam
      pretreatment units. The renewable carbon product demonstrated a desirable surface
      area of 872 m2/g and capacitance of up to 109 F/g when made into an electric
      double layer supercapacitor. The capacitor exhibited nearly ideal capacitive
      behavior with 90.5% capacitance retention after 5000 cycles.

PMID- 29844473
TI  - Expansion of human primary hepatocytes in vitro through their amplification as
      liver progenitors in a 3D organoid system.
AB  - Despite decades of investigation on the proliferation of adult human primary
      hepatocytes, their expansion in vitro still remains challenging. To later be able
      to consider hepatocytes as a cell therapy alternative or bridge to liver
      transplantation, dramatically impeded by a shortage in liver donors, the first
      step is having an almost unlimited source of these cells. The banking of
      transplantable hepatocytes also implies a protocol for their expansion that can
      be compatible with large-scale production. We show that adult human primary
      hepatocytes when grown in 3D organoids are easily amplified, providing a
      substantial source of functional hepatocytes ready for transplantation. Following
      their plating, differentiated human hepatocytes are amplified during a transient
      and reversible step as liver progenitors, and can subsequently be converted back
      to mature differentiated hepatocytes. The protocol we propose is not only
      compatible with automated and high-throughput cell culture systems, thanks to the
      expansion of hepatocytes in suspension, but also guarantees the generation of a
      high number of functional cells from the same patient sample, with a relatively
      easy set up.

PMID- 29844474
TI  - NPTX2 is a key component in the regulation of anxiety.
AB  - Anxiety disorders significantly impair quality of life. However, limited
      knowledge of the underlying mechanisms impedes the development of effective
      therapeutics. Previous studies have suggested that the expression of the Nptx2
      gene is associated with anxiety, but the neurobiological processes underlying
      this association remain unclear. We generated multiple mouse models with knockout
      or overexpression of Nptx2 in specific brain regions and during different
      developmental stages to assess anxiety, adult neurogenesis, and glucocorticoid
      related gene expression. Our results provide evidence that Nptx2 expression in
      the adult hippocampus regulates anxiety in mice. Eliminating Nptx2 expression in
      either the developing mouse brain or in adulthood leads to increased anxiety
      levels. The increase in anxiety was evident in hippocampus-specific Nptx2
      knockout mice, but not in an amygdala specific knockouts. Gene expression
      analysis revealed increased expression of glucocorticoid receptor target genes in
      Nptx2 knockout mice after acute stress. Overexpression of Nptx2 in the
      hippocampus alleviates stress-induced anxious behaviors and reverses the changes
      in expression of glucocorticoid receptor related genes. In conclusion, we
      demonstrate that Nptx2 in the hippocampus performs a critical role in modulating
      anxiety, hippocampal cell proliferation, and glucocorticoid receptor related gene
      expression. Our results suggest Nptx2 may be a potential target for anxiolytic
      therapeutics.

PMID- 29844475
TI  - Does human language limit translatability of clinical and preclinical addiction
      research?

PMID- 29844476
TI  - Not worth the wait: cocaine alters reward processing in the nucleus accumbens.

PMID- 29844477
TI  - Serum metabolite profile associated with incident type 2 diabetes in Koreans:
      findings from the Korean Genome and Epidemiology Study.
AB  - The identification of metabolic alterations in type 2 diabetes (T2D) is useful
      for elucidating the pathophysiology of the disease and in classifying high-risk
      individuals. In this study, we prospectively examined the associations between
      serum metabolites and T2D risk in a Korean community-based cohort (the Ansan
      Ansung cohort). Data were obtained from 1,939 participants with available
      metabolic profiles and without diabetes, cardiovascular disease, or cancer at
      baseline. The acylcarnitine, amino acid, amine, and phospholipid levels in
      fasting serum samples were analyzed by targeted metabolomics. During the 8-year
      follow-up period, we identified 282 cases of incident T2D. Of all metabolites
      measured, 22 were significantly associated with T2D risk. Specifically, serum
      levels of alanine, arginine, isoleucine, proline, tyrosine, valine, hexose and
      five phosphatidylcholine diacyls were positively associated with T2D risk,
      whereas lyso-phosphatidylcholine acyl C17:0 and C18:2 and other
      glycerophospholipids were negatively associated with T2D risk. The associated
      metabolites were further correlated with T2D-relevant risk factors such as
      insulin resistance and triglyceride indices. In addition, a healthier diet (as
      measured by the modified recommended food score) was independently associated
      with T2D risk. Alterations of metabolites such as amino acids and choline
      containing phospholipids appear to be associated with T2D risk in Korean adults.

PMID- 29844479
TI  - A new genetic mechanism of natural gas accumulation.
AB  - Natural gas of organic origin is primarily biogenic or thermogenic; however, the
      formation of natural gas is occasionally attributed to hydrothermal activity. The
      Precambrian dolomite reservoir of the Anyue gas field is divided into three
      stages. Dolomite-quartz veins were precipitated after two earlier stages of
      dolomite deposition. Fluid inclusions in the dolomite and quartz are divided into
      pure methane (P-type), methane-bearing (M-type), aqueous (W-type), and solid
      bitumen-bearing (S-type) inclusions. The W-type inclusions within the quartz and
      buried dolomite homogenized between 107  degrees C and 223  degrees C.
      Furthermore, the trapping temperatures and pressures of the fluid (249  degrees C
      to 319  degrees C and 1619 bar to 2300 bar, respectively) are obtained from the
      intersections of the isochores of the P-type and the coeval W-type inclusions in
      the quartz. However, the burial history of the reservoir indicates that the
      maximum burial temperature did not exceed 230  degrees C. Thus, the generation of
      the natural gas was not caused solely by the burial of the dolomite reservoir.
      The results are also supported by the presence of paragenetic pyrobitumen and MVT
      lead-zinc ore. A coupled system of occasional invasion by hydrothermal fluids and
      burial of the reservoir may represent a new genetic model for natural gas
      accumulation in this gas field.

PMID- 29844478
TI  - Compromised microvascular oxygen delivery increases brain tissue vulnerability
      with age.
AB  - Despite the possible role of impaired cerebral tissue oxygenation in age-related
      cognition decline, much is still unknown about the changes in brain tissue pO2
      with age. Using a detailed investigation of the age-related changes in cerebral
      tissue oxygenation in the barrel cortex of healthy, awake aged mice, we
      demonstrate decreased arteriolar and tissue pO2 with age. These changes are
      exacerbated after middle-age. We further uncovered evidence of the presence of
      hypoxic micro-pockets in the cortex of awake old mice. Our data suggests that
      from young to middle-age, a well-regulated capillary oxygen supply maintains the
      oxygen availability in cerebral tissue, despite decreased tissue pO2 next to
      arterioles. After middle-age, due to decreased hematocrit, reduced capillary
      density and higher capillary transit time heterogeneity, the capillary network
      fails to compensate for larger decreases in arterial pO2. The substantial
      decrease in brain tissue pO2, and the presence of hypoxic micro-pockets after
      middle-age are of significant importance, as these factors may be related to
      cognitive decline in elderly people.

PMID- 29844480
TI  - Asymmetric distribution of biomolecules of maternal origin in the Xenopus laevis
      egg and their impact on the developmental plan.
AB  - Asymmetric cell division is a ubiquitous feature during the development of higher
      organisms. Asymmetry is achieved by differential localization or activities of
      biological molecules such as proteins, and coding and non-coding RNAs. Here, we
      present subcellular transcriptomic and proteomic analyses along the animal
      vegetal axis of Xenopus laevis eggs. More than 98% of the maternal mRNAs could be
      categorized into four localization profile groups: animal, vegetal, extremely
      vegetal, and a newly described group of mRNAs that we call extremely animal,
      which are mRNAs enriched in the animal cortex region. 3'UTRs of localized mRNAs
      were analyzed for localization motifs. Several putative motifs were discovered
      for vegetal and extremely vegetal mRNAs, while no distinct conserved motifs for
      the extremely animal mRNAs were identified, suggesting different localization
      mechanisms. Asymmetric profiles were also found for proteins, with correlation to
      those of corresponding mRNAs. Based on unexpected observation of the profiles of
      the homoeologous genes exd2 we propose a possible mechanism of genetic evolution.

PMID- 29844481
TI  - Re-entrant bimodality in spheroidal chiral swimmers in shear flow.
AB  - We use a continuum model to report on the behavior of a dilute suspension of
      chiral swimmers subject to externally imposed shear in a planar channel. Swimmer
      orientation in response to the imposed shear can be characterized by two distinct
      phases of behavior, corresponding to unimodal or bimodal distribution functions
      for swimmer orientation along the channel. These phases indicate the occurrence
      (or not) of a population splitting phenomenon changing the swimming direction of
      a macroscopic fraction of active particles to the exact opposite of that dictated
      by the imposed flow. We present a detailed quantitative analysis elucidating the
      complexities added to the population splitting behavior of swimmers when they are
      chiral. In particular, the transition from unimodal to bimodal and vice versa are
      shown to display a re-entrant behavior across the parameter space spanned by
      varying the chiral angular speed. We also present the notable effects of particle
      aspect ratio and self-propulsion speed on system phase behavior and discuss
      potential implications of our results in applications such as swimmer
      separation/sorting.

PMID- 29844482
TI  - In situ measurement of autophagy under nutrient starvation based on interfacial
      pH sensing.
AB  - In this study, we report a novel method for the in situ measurement of autophagy
      under nutrient starvation using a principle of semiconductor technology. A
      semiconductor-based field-effect transistor (FET) biosensor enables the direct
      detection of ionic or molecular charges under biological conditions. In
      particular, cellular respiration accompanied by the generation of carbon dioxide
      can be continuously and directly monitored as a change in pH at a cell/sensor
      interface. When autophagy was induced in HeLa cells on a FET biosensor under
      nutrient starvation, the surface potential increased more significantly for about
      15 h than that for nonstarved cells. This positive shift indicates an increase in
      the number of hydrogen ions produced from the respiration of starved cells
      because the sensing surface was previously designed to be sensitive to pH
      variation. Therefore, we have found that cellular respiration is more activated
      by autophagy under nutrient starvation because the amino acids that decomposed
      from proteins in autophagic cells would have been rapidly spent in cellular
      respiration.

PMID- 29844483
TI  - PhosContext2vec: a distributed representation of residue-level sequence contexts
      and its application to general and kinase-specific phosphorylation site
      prediction.
AB  - Phosphorylation is the most important type of protein post-translational
      modification. Accordingly, reliable identification of kinase-mediated
      phosphorylation has important implications for functional annotation of
      phosphorylated substrates and characterization of cellular signalling pathways.
      The local sequence context surrounding potential phosphorylation sites is
      considered to harbour the most relevant information for phosphorylation site
      prediction models. However, currently there is a lack of condensed vector
      representation for this important contextual information, despite the presence of
      varying residue-level features that can be constructed from sequence homology
      profiles, structural information, and physicochemical properties. To address this
      issue, we present PhosContext2vec which is a distributed representation of
      residue-level sequence contexts for potential phosphorylation sites and
      demonstrate its application in both general and kinase-specific phosphorylation
      site predictions. Benchmarking experiments indicate that PhosContext2vec could
      achieve promising predictive performance compared with several other existing
      methods for phosphorylation site prediction. We envisage that PhosContext2vec, as
      a new sequence context representation, can be used in combination with other
      informative residue-level features to improve the classification performance in a
      number of related bioinformatics tasks that require appropriate residue-level
      feature vector representation and extraction. The web server of PhosContext2vec
      is publicly available at http://phoscontext2vec.erc.monash.edu/.

PMID- 29844484
TI  - Short-term increase in discs' apparent diffusion is associated with pain and
      mobility improvements after spinal mobilization for low back pain.
AB  - Pain perception, trunk mobility and apparent diffusion coefficient (ADC) within
      all lumbar intervertebral discs (IVDs) were collected before and shortly after
      posterior-to-anterior (PA) mobilizations in 16 adults with acute low back pain.
      Using a pragmatic approach, a trained orthopaedic manual physical therapist
      applied PA mobilizations to the participants' spine, in accordance with his
      examination findings. ADC all was computed from diffusion maps as the mean of
      anterior (ADC ant ), middle (ADC mid ), and posterior (ADC post ) portions of the
      IVD. After mobilization, pain ratings and trunk mobility were significantly
      improved and a significant increase in ADC all values was observed. The greatest
      ADC all changes were observed at the L3-L4 and L4-L5 levels and were mainly
      explained by changes in ADC ant and ADC post , respectively. No significant
      changes in ADC were observed at L5-S1 level. The reduction in pain and largest
      changes in ADC observed at the periphery of the hyperintense IVD region suggest
      that increased peripheral random motion of water molecules is implicated in the
      IVD nociceptive response modulation. Additionally, ADC changes were observed at
      remote IVD anatomical levels that did not coincide with the PA spinal
      mobilization application level.

PMID- 29844485
TI  - A comprehensive analysis of e-CAS cell line reveals they are mouse macrophages.
AB  - The 3Rs principles (Replacement, Reduction and Refinement) are focused on finding
      alternatives to the use of animals in research. In this regard, cell lines are
      popular and useful tools for the replacement of primary cells in in vitro
      studies. However, around 15-30% of cell lines used in research have been
      misidentified or cross-contaminated generating concerns about the results
      obtained from experiments that use them. Here we described how old aliquots of an
      equine macrophage cell line (e-CAS) stored at the Animal Health Trust did not
      contain equine cells but macrophages of murine origin (m-CAS).

PMID- 29844486
TI  - Children's screen time alters the expression of saliva extracellular miR-222 and
      miR-146a.
AB  - An imbalance between energy uptake and energy expenditure is the most important
      reason for increasing trends in obesity starting from early in life.
      Extracellular miRNAs are expressed in all bodily fluids and their expression is
      influenced by a broad range of stimuli. We examined whether screen time, physical
      activity and BMI are associated with children's salivary extracellular miR-222
      and miR-146a expression. In 80 children the extracellular fraction of saliva was
      obtained by means of differential centrifugation and ultracentrifugation.
      Expression levels of miR-222 and miR-146a were profiled by qPCR. We studied the
      association between children's salivary extracellular miRNA expression and screen
      time, physical activity and BMI using mixed models, while accounting for
      potential confounders. We found that higher screen time was positively associated
      with salivary extracellular miR-222 and miR-146a levels. On average, one hour
      more screen time use per week was associated with a 3.44% higher miR-222 (95% CI:
      1.34 to 5.58; p = 0.002) and 1.84% higher miR-146a (95% CI: -0.04 to 3.75; p =
      0.055) level in saliva. BMI and physical activity of the child were not
      significantly associated with either miR-222 or miR-146a. A sedentary behaviour,
      represented by screen time use in children, is associated with discernible
      changes in salivary expression of miR-146a and or miR-222. These miRNA targets
      may emerge attractive candidates to explore the role of these exposures in
      developmental processes of children's health.

PMID- 29844487
TI  - Nanopore sequencing of drug-resistance-associated genes in malaria parasites,
      Plasmodium falciparum.
AB  - Here, we report the application of a portable sequencer, MinION, for genotyping
      the malaria parasite Plasmodium falciparum. In the present study, an amplicon
      mixture of nine representative genes causing resistance to anti-malaria drugs is
      diagnosed. First, we developed the procedure for four laboratory strains (3D7,
      Dd2, 7G8, and K1), and then applied the developed procedure to ten clinical
      samples. We sequenced and re-sequenced the samples using the obsolete flow cell
      R7.3 and the most recent flow cell R9.4. Although the average base-call accuracy
      of the MinION sequencer was 74.3%, performing >50 reads at a given position
      improves the accuracy of the SNP call, yielding a precision and recall rate of
      0.92 and 0.8, respectively, with flow cell R7.3. These numbers increased
      significantly with flow cell R9.4, in which the precision and recall are 1 and
      0.97, respectively. Based on the SNP information, the drug resistance status in
      ten clinical samples was inferred. We also analyzed K13 gene mutations from 54
      additional clinical samples as a proof of concept. We found that a novel amino
      acid changing variation is dominant in this area. In addition, we performed a
      small population-based analysis using 3 and 5 cases (K13) and 10 and 5 cases
      (PfCRT) from Thailand and Vietnam, respectively. We identified distinct genotypes
      from the respective regions. This approach will change the standard methodology
      for the sequencing diagnosis of malaria parasites, especially in developing
      countries.

PMID- 29844488
TI  - Sedimentary environment and depositional evolution of the Mesoproterozoic
      Bingmagou Formation on the southern margin of the North China Craton.
AB  - The Precambrian sedimentary strata on the southern margin of the North China
      Craton are well developed and widely exposed, making the region ideal for the
      study of depositional processes. However, because of the length of the
      depositional history and the lack of biogenic criteria, interpretations of the
      sedimentary environments of the Precambrian strata are often based on the
      tectonic background, geographical environment, rock type and sedimentary
      structures, resulting in controversies in the literature. In this study of the
      Bingmagou Formation in the Ruyang Group on the southern margin of the North China
      Craton, analysis of petrologic features, palaeocurrents and sedimentary facies is
      combined with regional correlation of relevant strata and the reconstruction of
      ancient landforms to explain the depositional environments and environmental
      transitions. Dominated by marine deposits on the southern margin of the North
      China Craton, the sedimentary strata of the Ruyang Group unconformably overlie
      the Archean crystalline basement or Proterozoic Xionger Group. As the lowermost
      unit of the Ruyang Group, the Bingmagou Formation, which was depositionally
      controlled by topography and faults and received abundant detrital material, is a
      highly distinctive set of sedimentary strata and represents an environmental
      transition from alluvial fan to sandy coast.

PMID- 29844489
TI  - Correlative atomic force microscopy quantitative imaging-laser scanning confocal
      microscopy quantifies the impact of stressors on live cells in real-time.
AB  - There is an urgent need to assess the effect of anthropogenic chemicals on model
      cells prior to their release, helping to predict their potential impact on the
      environment and human health. Laser scanning confocal microscopy (LSCM) and
      atomic force microscopy (AFM) have each provided an abundance of information on
      cell physiology. In addition to determining surface architecture, AFM in
      quantitative imaging (QI) mode probes surface biochemistry and cellular mechanics
      using minimal applied force, while LSCM offers a window into the cell for imaging
      fluorescently tagged macromolecules. Correlative AFM-LSCM produces complimentary
      information on different cellular characteristics for a comprehensive picture of
      cellular behaviour. We present a correlative AFM-QI-LSCM assay for the
      simultaneous real-time imaging of living cells in situ, producing multiplexed
      data on cell morphology and mechanics, surface adhesion and ultrastructure, and
      real-time localization of multiple fluorescently tagged macromolecules. To
      demonstrate the broad applicability of this method for disparate cell types, we
      show altered surface properties, internal molecular arrangement and oxidative
      stress in model bacterial, fungal and human cells exposed to 2,4
      dichlorophenoxyacetic acid. AFM-QI-LSCM is broadly applicable to a variety of
      cell types and can be used to assess the impact of any multitude of contaminants,
      alone or in combination.

PMID- 29844490
TI  - Mammalian Solute Carrier (SLC)-like transporters of Legionella pneumophila.
AB  - Acquisition of nutrients during intra-vacuolar growth of L. pneumophila within
      macrophages or amoebae is poorly understood. Since many genes of L. pneumophila
      are acquired by inter-kingdom horizontal gene transfer from eukaryotic hosts, we
      examined the presence of human solute carrier (SLC)-like transporters in the L.
      pneumophila genome using I-TASSER to assess structural alignments. We identified
      11 SLC-like putative transporters in L. pneumophila that are structurally similar
      to SLCs, eight of which are amino acid transporters, and one is a tricarboxylate
      transporter. The two other transporters, LstA and LstB, are structurally similar
      to the human glucose transporter, SLC2a1/Glut1. Single mutants of lstA or lstB
      have decreased ability to import, while the lstA/lstB double mutant is severely
      defective for uptake of glucose. While lstA or lstB single mutants are not
      defective in intracellular proliferation within Acanthamoeba polyphaga and human
      monocyte-derived macrophages, the lstA/lstB double mutant is severely defective
      in both host cells. The two phenotypic defects of the lstA/lstB double mutant in
      uptake of glucose and intracellular replication are both restored upon
      complementation of either lstA or lstB. Our data show that the two glucose
      transporters, LstA and LstB, are redundant and are required for intracellular
      replication within human macrophages and amoebae.

PMID- 29844491
TI  - The evolution of genomic and epigenomic features in two Pleurotus fungi.
AB  - Pleurotus tuoliensis (Bailinggu, designated Pt) and P. eryngii var. eryngii
      (Xingbaogu, designated Pe) are highly valued edible mushrooms. We report de novo
      assemblies of high-quality genomes for both mushrooms based on PacBio RS II
      sequencing and annotation of all identified genes. A comparative genomics
      analysis between Pt and Pe with P. ostreatus as an outgroup taxon revealed
      extensive genomic divergence between the two mushroom genomes primarily due to
      the rapid gain of taxon-specific genes and disruption of synteny in either taxon.
      The re-appraised phylogenetic relationship between Pt and Pe at the genome-wide
      level validates earlier proposals to designate Pt as an independent species.
      Variation of the identified wood-decay-related gene content can largely explain
      the variable adaptation and host specificity of the two mushrooms. On the basis
      of the two assembled genome sequences, methylomes and the regulatory roles of DNA
      methylation in gene expression were characterized and compared. The genome,
      methylome and transcriptome data of these two important mushrooms will provide
      valuable information for advancing our understanding of the evolution of
      Pleurotus and related genera and for facilitating genome- and epigenome-based
      strategies for mushroom breeding.

PMID- 29844492
TI  - Evolution of oncogenic signatures of mutation hotspots in tyrosine kinases
      supports the atavistic hypothesis of cancer.
AB  - Cancer has been shown as an evolutionary process emerging hallmarks that are
      reminiscent of unicellular organisms. Since cancer is mostly driven by somatic
      mutations, especially by oncogenic hotspot mutations, we proposed a molecular
      atavism of cancer caused by gain-of-function mutations in oncogenes. As tyrosine
      kinase (TK) family contains the largest subgroup of oncogenes with hotspot
      mutations, we traced the most predominant mutation hotspots of TK oncogenes
      across phylogeny with the domain information and adjacent sequences integrated as
      onco-signatures. We detected 9 out of 17 TK oncogenes with onco-homologs
      possessing an onco-signature, which could be divided into two classes by whether
      their onco-homologs existed in mammals or not. In Class I we identified mammalian
      onco-homologs assuming oncogenic functions with onco-signatures always intact in
      cancer, such as HCK and LYN. In Class II with no bona fide mammalian onco
      homologs, Pyk2, a protist onco-homolog with an onco-signature of BRAF was found
      assuming oncogenic-like functions. Onco-signatures in both classes root deep in
      the primitive system. Together, these evidences supported our proposal that
      cancer can be driven by reverse evolution of oncogenes through gain-of-function
      mutations. And also for the first time, we provided the specific targets for
      experimental verification of the atavistic hypothesis of cancer.

PMID- 29844493
TI  - Chinese famine exposure in infancy and metabolic syndrome in adulthood: results
      from the China health and retirement longitudinal study.
AB  - BACKGROUND/OBJECTIVES: To explore the association between famine exposure in
      early life and the risk of metabolic syndrome in the Chinese adults.
      SUBJECTS/METHODS: A total of 2148 participants aged 50s were selected from a
      large national epidemiological survey in the China. The logistic regression
      models were used to analyze the association between famine exposure in early life
      and risk of metabolic syndrome in adulthood. RESULTS: The prevalence of metabolic
      syndrome among individuals in the preschool exposed group, infant exposed group,
      fetal exposed group, and the non-exposed group was 37.9, 43.5, 37.5, and 34.0%,
      respectively. The prevalence of metabolic syndrome in the infant exposed group
      was significantly higher than the non-exposed group (43.5 vs. 34.0%, P = 0.006).
      Compared with the non-exposed group, individuals who exposed to the famine in
      infancy significantly increased the risk of metabolic syndrome (OR = 1.83; 95%
      CI: 1.24, 2.70) after adjusting for gender, smoking status, drinking status,
      physical activity, and the educational levels of participants and their parents.
      However, similar results were not observed in the fetal (OR = 1.25; 95% CI: 0.89,
      1.74) or the preschool (OR = 1.30; 95% CI: 0.97, 1.75) exposed groups.
      CONCLUSIONS: The Great China famine exposure during infancy was linked with the
      elevated risk of metabolic syndrome in adults aged 50s, which provided further
      evidence for the developmental origins hypothesis.

PMID- 29844494
TI  - Investigation of dose-rate effects and cell-cycle distribution under protracted
      exposure to ionizing radiation for various dose-rates.
AB  - During exposure to ionizing radiation, sub-lethal damage repair (SLDR) competes
      with DNA damage induction in cultured cells. By virtue of SLDR, cell survival
      increases with decrease of dose-rate, so-called dose-rate effects (DREs). Here,
      we focused on a wide dose-rate range and investigated the change of cell-cycle
      distribution during X-ray protracted exposure and dose-response curves via hybrid
      analysis with a combination of in vitro experiments and mathematical modelling.
      In the course of flow-cytometric cell-cycle analysis and clonogenic assays, we
      found the following responses in CHO-K1 cells: (1) The fraction of cells in S
      phase gradually increases during 6 h exposure at 3.0 Gy/h, which leads to radio
      resistance. (2) Slight cell accumulation in S and G2/M phases is observed after
      exposure at 6.0 Gy/h for more than 10 hours. This suggests that an increase of
      SLDR rate for cells in S phase during irradiation may be a reproducible factor to
      describe changes in the dose-response curve at dose-rates of 3.0 and 6.0 Gy/h. By
      re-evaluating cell survival for various dose-rates of 0.186-60.0 Gy/h considering
      experimental-based DNA content and SLDR, it is suggested that the change of S
      phase fraction during irradiation modulates the dose-response curve and is
      possibly responsible for some inverse DREs.

PMID- 29844495
TI  - Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR.
AB  - P53-binding protein 1 (53BP1) regulates the double-strand break (DSB) repair
      pathway choice. A recently identified 53BP1-binding protein Tudor-interacting
      repair regulator (TIRR) modulates the access of 53BP1 to DSBs by masking the
      H4K20me2 binding surface on 53BP1, but the underlying mechanism remains unclear.
      Here we report the 1.76-A crystal structure of TIRR in complex with 53BP1 tandem
      Tudor domain. We demonstrate that the N-terminal region (residues 10-24) and the
      L8-loop of TIRR interact with 53BP1 Tudor through three loops (L1, L3, and L1').
      TIRR recognition blocks H4K20me2 binding to 53BP1 Tudor and modulates 53BP1
      functions in vivo. Structure comparisons identify a TIRR histidine (H106) that is
      absent from the TIRR homolog Nudt16, but essential for 53BP1 Tudor binding.
      Remarkably, mutations mimicking TIRR binding modules restore the disrupted
      binding of Nudt16-53BP1 Tudor. Our studies elucidate the mechanism by which TIRR
      recognizes 53BP1 Tudor and functions as a cellular inhibitor of the histone
      methyl-lysine readers.

PMID- 29844496
TI  - Psilocybin and MDMA reduce costly punishment in the Ultimatum Game.
AB  - Disruptions in social decision-making are becoming evident in many psychiatric
      conditions. These are studied using paradigms investigating the psychological
      mechanisms underlying interpersonal interactions, such as the Ultimatum Game
      (UG). Rejection behaviour in the UG represents altruistic punishment - the costly
      punishment of norm violators - but the mechanisms underlying it require
      clarification. To investigate the psychopharmacology of UG behaviour, we carried
      out two studies with healthy participants, employing serotonergic agonists:
      psilocybin (open-label, within-participant design, N = 19) and 3,4
      methylenedioxymethamphetamine (MDMA; placebo-controlled, double-blind, crossover
      design, N = 20). We found that both MDMA and psilocybin reduced rejection of
      unfair offers (odds ratio: 0.57 and 0.42, respectively). The reduction in
      rejection rate following MDMA was associated with increased prosociality (R2 =
      0.26, p = 0.025). In the MDMA study, we investigated third-party decision-making
      and proposer behaviour. MDMA did not reduce rejection in the third-party
      condition, but produced an increase in the amount offered to others (Cohen's d =
      0.82). We argue that these compounds altered participants' conceptualisation of
      'social reward', placing more emphasis on the direct relationship with
      interacting partners. With these compounds showing efficacy in drug-assisted
      psychotherapy, these studies are an important step in the further
      characterisation of their psychological effects.

PMID- 29844497
TI  - Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via
      testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice.
AB  - Sudden cardiac death (SCD) is associated with both electrical and ischemic
      substrates, and is a major cause of ischemic heart disease mortality worldwide.
      Male sex predisposes to SCD but the underlying mechanisms are incompletely
      understood. KCNE4, a cardiac arrhythmia-associated potassium channel beta
      subunit, is upregulated by 5alpha-dihydrotestosterone (DHT). Thus, ventricular
      Kcne4 expression is low in young adult female mice, but high in males and
      postmenopausal (12+ months) females. Despite causing a sex-independent electrical
      substrate at 13 months of age (22% QT prolongation in both males and females; P <
      0.01), Kcne4 deletion preferentially predisposed aged male mice to
      ischemia/reperfusion (IR)-provoked ventricular tachyarrhythmias. Interestingly,
      Kcne4 deletion caused baseline induction of cardioprotective RISK and SAFE
      pathways in 13-m-old female, but not male, mice. IR-invoked RISK/SAFE induction
      was also deficient in male but not female Kcne4-/- mice. Pharmacological
      inhibition of RISK/SAFE pathways in Kcne4-/- females eliminated sex-specific
      differences in IR-invoked tachyarrhythmia predisposition. Furthermore, castration
      of Kcne4-/- males eliminated sex-specific differences in both baseline and post
      IR RISK/SAFE pathway induction, and tachyarrhythmia predisposition. Our results
      demonstrate for the first time that male sex can predispose in aged mice to
      dangerous ventricular tachyarrhythmias despite sex-independent electrical and
      ischemic substrates, because of testosterone-dependent impairment of RISK/SAFE
      pathway induction.

PMID- 29844498
TI  - Patterns of species richness and the center of diversity in modern Indo-Pacific
      larger foraminifera.
AB  - Symbiont-bearing Larger Benthic Foraminifera (LBF) are ubiquitous components of
      shallow tropical and subtropical environments and contribute substantially to
      carbonaceous reef and shelf sediments. Climate change is dramatically affecting
      carbonate producing organisms and threatens the diversity and structural
      integrity of coral reef ecosystems. Recent invertebrate and vertebrate surveys
      have identified the Coral Triangle as the planet's richest center of marine life
      delineating the region as a top priority for conservation. We compiled and
      analyzed extensive occurrence records for 68 validly recognized species of LBF
      from the Indian and Pacific Ocean, established individual range maps and applied
      Minimum Convex Polygon (MCP) and Species Distribution Model (SDM) methodologies
      to create the first ocean-wide species richness maps. SDM output was further used
      for visualizing latitudinal and longitudinal diversity gradients. Our findings
      provide strong support for assigning the tropical Central Indo-Pacific as the
      world's species-richest marine region with the Central Philippines emerging as
      the bullseye of LBF diversity. Sea surface temperature and nutrient content were
      identified as the most influential environmental constraints exerting control
      over the distribution of LBF. Our findings contribute to the completion of
      worldwide research on tropical marine biodiversity patterns and the
      identification of targeting centers for conservation efforts.

PMID- 29844499
TI  - Categorical and Geographical Separation in Science.
AB  - We study scientific collaboration at the level of universities. The scope of this
      study is to answer two fundamental questions: (i) can one indicate a category
      (i.e., a scientific discipline) that has the greatest impact on the rank of the
      university and (ii) do the best universities collaborate with the best ones only?
      Restricting ourselves to the 100 best universities from year 2009 we show how the
      number of publications in certain categories correlates with the university rank.
      Strikingly, the expected negative trend is not observed in all cases - for some
      categories even positive values are obtained. After applying Principal Component
      Analysis we observe clear categorical separation of scientific disciplines,
      dividing the papers into almost separate clusters connected to natural sciences,
      medicine and arts and humanities. Moreover, using complex networks analysis, we
      give hints that the scientific collaboration is still embedded in the physical
      space and the number of common papers decays with the geographical distance
      between them.

PMID- 29844500
TI  - A Novel Geometry-Based Approach to Infer Protein Interface Similarity.
AB  - The protein interface is key to understand protein function, providing a vital
      insight on how proteins interact with each other and with other molecules. Over
      the years, many computational methods to compare protein structures were
      developed, yet evaluating interface similarity remains a very difficult task.
      Here, we present PatchBag - a geometry based method for efficient comparison of
      protein surfaces and interfaces. PatchBag is a Bag-Of-Words approach, which
      represents complex objects as vectors, enabling to search interface similarity in
      a highly efficient manner. Using a novel framework for evaluating interface
      similarity, we show that PatchBag performance is comparable to state-of-the-art
      alignment-based structural comparison methods. The great advantage of PatchBag is
      that it does not rely on sequence or fold information, thus enabling to detect
      similarities between interfaces in unrelated proteins. We propose that PatchBag
      can contribute to reveal novel evolutionary and functional relationships between
      protein interfaces.

PMID- 29844501
TI  - Possible Obesogenic Effects of Bisphenols Accumulation in the Human Brain.
AB  - Evidence of bisphenols' obesogenic effects on humans is mixed and inconsistent.
      We aimed to explore the presence of bisphenol A (BPA), bisphenol F (BPF) and
      chlorinated BPA (ClBPA), collectively called the bisphenols, in different brain
      regions and their association with obesity using post-mortem hypothalamic and
      white matter brain material from twelve pairs of obese (body mass index (BMI) >30
      kg/m2) and normal-weight individuals (BMI <25 kg/m2). Mean ratios of
      hypothalamus:white matter for BPA, BPF and ClBPA were 1.5, 0.92, 0.95,
      respectively, suggesting no preferential accumulation of the bisphenols in the
      grey matter (hypothalamic) or white matter-enriched brain areas. We observed
      differences in hypothalamic concentrations among the bisphenols, with highest
      median level detected for ClBPA (median: 2.4 ng/g), followed by BPF (2.2 ng/g)
      and BPA (1.2 ng/g); similar ranking was observed for the white matter samples
      (median for: ClBPA-2.5 ng/g, BPF-2.3 ng/g, and BPA-1.0 ng/g). Furthermore, all
      bisphenol concentrations, except for white-matter BPF were associated with
      obesity (p < 0.05). This is the first study reporting the presence of bisphenols
      in two distinct regions of the human brain. Bisphenols accumulation in the white
      matter-enriched brain tissue could signify that they are able to cross the blood
      brain barrier.

PMID- 29844502
TI  - Characterizing co-expression networks underpinning maize stalk rot virulence in
      Fusarium verticillioides through computational subnetwork module analyses.
AB  - Fusarium verticillioides is recognized as an important stalk rot pathogen of
      maize worldwide, but our knowledge of genetic mechanisms underpinning this
      pathosystem is limited. Previously, we identified a striatin-like protein Fsr1
      that plays an important role in stalk rot. To further characterize transcriptome
      networks downstream of Fsr1, we performed next-generation sequencing (NGS) to
      investigate relative read abundance and also to infer co-expression networks
      utilizing the preprocessed expression data through partial correlation. We used a
      probabilistic pathway activity inference strategy to identify functional
      subnetwork modules likely involved in virulence. Each subnetwork modules
      consisted of multiple correlated genes with coordinated expression patterns, but
      the collective activation levels were significantly different in F.
      verticillioides wild type versus fsr1 mutant. We also identified putative hub
      genes from predicted subnetworks for functional validation and network robustness
      studies through mutagenesis, virulence and qPCR assays. Our results suggest that
      these genes are important virulence genes that regulate the expression of closely
      correlated genes, demonstrating that these are important hubs of their respective
      subnetworks. Lastly, we used key F. verticillioides virulence genes to
      computationally predict a subnetwork of maize genes that potentially respond to
      fungal genes by applying cointegration-correlation-expression strategy.

PMID- 29844503
TI  - Fluorescent impurity emitter in toluene and its photon emission properties.
AB  - Single fluorescent emitters like colloidal quantum dots or single molecules are
      usually prepared in solutions and spin-coated onto cover glasses for studying.
      Toluene has been a widely used solvent in such studies. Here, we report on a
      fluorescent impurity emitter contained in toluene and its optical properties. The
      emission spectra of the single emitters show multiple peaks with the main peak
      varying from 2.03 eV (610 nm) to 2.14 eV (580 nm) and a red-shifted side peak
      with an average separation of 167 meV from the main peak. The emitted photons
      show a strong anti-bunching with a fluorescence lifetime of a few nanoseconds.
      They show very fast blinking behavior which cannot be properly detected by time
      trajectory of photoluminescence intensity. An analysis based on the second-order
      correlation functions reveals that a three-level model can explain our
      measurements well and that the blinking transition time ranges only a few tens of
      microseconds. This single emitter in toluene is clearly distinguished from the
      fluorescent centers in the cover glass by their respective emission spectra. The
      single emitters in the cover glass also exhibit fast blinking behavior. These
      background emitters should be carefully identified and distinguished while
      studying the single fluorescent emitters.

PMID- 29844504
TI  - Influence of Household Water Filters on Bacteria Growth and Trace Metals in Tap
      Water of Doha, Qatar.
AB  - Deteriorating water quality from aging infrastructure, growing threat of
      pollution from industrialization and urbanization, and increasing awareness about
      waterborne diseases are among the factors driving the surge in worldwide use of
      point-of-entry (POE) and point-of-use (POU) filters. Any adverse influence of
      such consumer point-of-use systems on quality of water at the tap remains poorly
      understood, however. We determined the chemical and microbiological changes in
      municipal water from the point of entry into the household plumbing system until
      it leaves from the tap in houses equipped with filters. We show that POE/POU
      devices can induce significant deterioration of the quality of tap water by
      functioning as traps and reservoirs for sludge, scale, rust, algae or slime
      deposits which promote microbial growth and biofilm formation in the household
      water distribution system. With changes in water pressure and physical or
      chemical disturbance of the plumbing system, the microorganisms and contaminants
      may be flushed into the tap water. Such changes in quality of household water
      carry a potential health risk which calls for some introspection in widespread
      deployment of POE/POU filters in water distribution systems.

PMID- 29844505
TI  - Phospholipid homeostasis, membrane tenacity and survival of Mtb in lipid rich
      conditions is determined by MmpL11 function.
AB  - The mycobacterial cell wall is a chemically complex array of molecular entities
      that dictate the pathogenesis of Mycobacterium tuberculosis. Biosynthesis and
      maintenance of this dynamic entity in mycobacterial physiology is still poorly
      understood. Here we demonstrate a requirement for M. tuberculosis MmpL11 in the
      maintenance of the cell wall architecture and stability in response to surface
      stress. In the presence of a detergent like Tyloxapol, a mmpL11 deletion mutant
      suffered from a severe growth attenuation as a result of altered membrane
      polarity, permeability and severe architectural damages. This mutant failed to
      tolerate permissible concentrations of cis-fatty acids suggesting its increased
      sensitivity to surface stress, evident as smaller colonies of the mutant outgrown
      from lipid rich macrophage cultures. Additionally, loss of MmpL11 led to an
      altered cellular fatty acid flux in the mutant: reduced incorporation into
      membrane cardiolipin was associated with an increased flux into the cellular
      triglyceride pool. This increase in storage lipids like triacyl glycerol (TAG)
      was associated with the altered metabolic state of higher dormancy-associated
      gene expression and decreased sensitivity to frontline TB drugs. This study
      provides a detailed mechanistic insight into the function of mmpL11 in stress
      adaptation of mycobacteria.

PMID- 29844506
TI  - Increased glutarate production by blocking the glutaryl-CoA dehydrogenation
      pathway and a catabolic pathway involving L-2-hydroxyglutarate.
AB  - Glutarate is a five carbon platform chemical produced during the catabolism of L
      lysine. It is known that it can be catabolized through the glutaryl-CoA
      dehydrogenation pathway. Here, we discover that Pseudomonas putida KT2440 has an
      additional glutarate catabolic pathway involving L-2-hydroxyglutarate (L-2-HG),
      an abnormal metabolite produced from 2-ketoglutarate (2-KG). In this pathway,
      CsiD, a Fe2+/2-KG-dependent glutarate hydroxylase, is capable of converting
      glutarate into L-2-HG, and LhgO, an L-2-HG oxidase, can catalyze L-2-HG into 2
      KG. We construct a recombinant strain that lacks both glutarate catabolic
      pathways. It can produce glutarate from L-lysine with a yield of 0.85 mol
      glutarate/mol L-lysine. Thus, L-2-HG anabolism and catabolism is a metabolic
      alternative to the glutaryl-CoA dehydrogenation pathway in P. putida KT2440; L
      lysine can be both ketogenic and glucogenic.

PMID- 29844507
TI  - Alcohol use effects on adolescent brain development revealed by simultaneously
      removing confounding factors, identifying morphometric patterns, and classifying
      individuals.
AB  - Group analysis of brain magnetic resonance imaging (MRI) metrics frequently
      employs generalized additive models (GAM) to remove contributions of confounding
      factors before identifying cohort specific characteristics. For example, the
      National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) used
      such an approach to identify effects of alcohol misuse on the developing brain.
      Here, we hypothesized that considering confounding factors before group analysis
      removes information relevant for distinguishing adolescents with drinking history
      from those without. To test this hypothesis, we introduce a machine-learning
      model that identifies cohort-specific, neuromorphometric patterns by
      simultaneously training a GAM and generic classifier on macrostructural MRI and
      microstructural diffusion tensor imaging (DTI) metrics and compare it to more
      traditional group analysis and machine-learning approaches. Using a baseline
      NCANDA MR dataset (N = 705), the proposed machine learning approach identified a
      pattern of eight brain regions unique to adolescents who misuse alcohol.
      Classifying high-drinking adolescents was more accurate with that pattern than
      using regions identified with alternative approaches. The findings of the joint
      model approach thus were (1) impartial to confounding factors; (2) relevant to
      drinking behaviors; and (3) in concurrence with the alcohol literature.

PMID- 29844508
TI  - An alpha-1,6-and alpha-1,3-linked glucan produced by Leuconostoc citreum ABK-1
      alternansucrase with nanoparticle and film-forming properties.
AB  - Alternansucrase catalyses the sequential transfer of glucose residues from
      sucrose onto another sucrose molecule to form a long chain polymer, known as
      "alternan". The alternansucrase-encoding gene from Leuconostoc citreum ABK-1
      (Lcalt) was successfully cloned and expressed in Escherichia coli. Lcalt encoded
      LcALT of 2,057 amino acid residues; the enzyme possessed an optimum temperature
      and pH of 40  degrees C and 5.0, respectively, and its' activity was stimulated
      up to 2.4-fold by the presence of Mn2+. Kinetic studies of LcALT showed a high
      transglycosylation activity, with Km 32.2 +/- 3.2 mM and kcat 290 +/- 12 s-1.
      Alternan generated by LcALT (Lc-alternan) harbours partially alternating alpha
      1,6 and alpha- 1,3 glycosidic linkages confirmed by NMR spectroscopy, methylation
      analysis, and partial hydrolysis of Lc-alternan products. In contrast to
      previously reported alternans, Lc-alternan can undergo self-assembly, forming
      nanoparticles with an average size of 90 nm in solution. At concentrations above
      15% (w/v), Lc-alternan nanoparticles disassemble and form a high viscosity
      solution, while this polymer forms a transparent film once dried.

PMID- 29844509
TI  - Rapid and Efficient FISH using Pre-Labeled Oligomer Probes.
AB  - Fluorescence in situ hybridization (FISH) is used to visualize the distribution
      of DNA elements within a genome. Conventional methods for FISH take 1-2 days.
      Here, we developed a simplified, rapid FISH technique using pre-labeled
      oligonucleotide probes (PLOPs) and tested the procedure using 18 PLOPs from 45S
      and 5S rDNA, Arabidopsis-type telomere, and newly-identified Panax ginseng
      specific tandem repeats. The 16 developed rDNA PLOPs can be universally applied
      to plants and animals. The telomere PLOPs can be utilized in most plants with
      Arabidopsis-type telomeres. The ginseng-specific PLOP can be used to distinguish
      P. ginseng from related Panax species. Differential labeling of PLOPs allowed us
      to simultaneously visualize different target loci while reducing the FISH
      hybridization time from ~16 h to 5 min. PLOP-FISH is efficient, reliable, and
      rapid, making it ideal for routine analysis, especially of newly sequenced
      genomes using either universal or specific targets, such as novel tandem repeats
      identified from whole-genome sequencing data.

PMID- 29844510
TI  - Hydrogen cyanide produced by the soil bacterium Chromobacterium sp. Panama
      contributes to mortality in Anopheles gambiae mosquito larvae.
AB  - Mosquito larvae continuously encounter microbes in their aquatic environment,
      which serve as food and play a critical role in successful development. In
      previous work, we isolated a Chromobacterium sp. (C.sp_P) with larvicidal
      activity from the midgut of dengue vector Aedes mosquitoes in Panama. In this
      study, we found a positive correlation between initial concentrations of C.sp_P
      and larval mortality rates, and that C.sp_P is more efficient at inducing larval
      mortality in a high nutrient environment. Multiple Chromobacterium species induce
      larval mortality with similar efficacy to C.sp_P except for C. subtsugae. We also
      found that a non-lethal dose of C.sp_P lengthens development time and increases
      mortality over multiple developmental stages, suggesting persistent effects of
      exposure. Additionally, we showed that larvicidal activity persists in the larval
      breeding water after removal of live bacteria, and that the larvicidal factor in
      C.sp_P-treated water is smaller than 3 kDa, heat resistant to 90  degrees C, and
      lost after vacuum centrifugation. We showed that C.sp_P produces hydrogen cyanide
      in culture and in larval water at concentrations sufficient to kill An. gambiae
      larvae, and treatment of the larval water with a cyanide antidote eliminated
      larvicidal activity. We conclude that a potential mechanism by which C.sp_P can
      induce larval mortality is via production of hydrogen cyanide.

PMID- 29844511
TI  - Cancer Characteristic Gene Selection via Sample Learning Based on Deep Sparse
      Filtering.
AB  - Identification of characteristic genes associated with specific biological
      processes of different cancers could provide insights into the underlying cancer
      genetics and cancer prognostic assessment. It is of critical importance to select
      such characteristic genes effectively. In this paper, a novel unsupervised
      characteristic gene selection method based on sample learning and sparse
      filtering, Sample Learning based on Deep Sparse Filtering (SLDSF), is proposed.
      With sample learning, the proposed SLDSF can better represent the gene expression
      level by the transformed sample space. Most unsupervised characteristic gene
      selection methods did not consider deep structures, while a multilayer structure
      may learn more meaningful representations than a single layer, therefore deep
      sparse filtering is investigated here to implement sample learning in the
      proposed SLDSF. Experimental studies on several microarray and RNA-Seq datasets
      demonstrate that the proposed SLDSF is more effective than several representative
      characteristic gene selection methods (e.g., RGNMF, GNMF, RPCA and PMD) for
      selecting cancer characteristic genes.

PMID- 29844512
TI  - Multilayer Aggregation with Statistical Validation: Application to Investor
      Networks.
AB  - Multilayer networks are attracting growing attention in many fields, including
      finance. In this paper, we develop a new tractable procedure for multilayer
      aggregation based on statistical validation, which we apply to investor networks.
      Moreover, we propose two other improvements to their analysis: transaction
      bootstrapping and investor categorization. The aggregation procedure can be used
      to integrate security-wise and time-wise information about investor trading
      networks, but it is not limited to finance. In fact, it can be used for different
      applications, such as gene, transportation, and social networks, were they
      inferred or observable. Additionally, in the investor network inference, we use
      transaction bootstrapping for better statistical validation. Investor
      categorization allows for constant size networks and having more observations for
      each node, which is important in the inference especially for less liquid
      securities. Furthermore, we observe that the window size used for averaging has a
      substantial effect on the number of inferred relationships. We apply this
      procedure by analyzing a unique data set of Finnish shareholders during the
      period 2004-2009. We find that households in the capital have high centrality in
      investor networks, which, under the theory of information channels in investor
      networks suggests that they are well-informed investors.

PMID- 29844513
TI  - Associations of passive muscle stiffness, muscle stretch tolerance, and muscle
      slack angle with range of motion: individual and sex differences.
AB  - Joint range of motion (ROM) is an important parameter for athletic performance
      and muscular injury risk. Nonetheless, a complete description of muscular factors
      influencing ROM among individuals and between men and women is lacking. We
      examined whether passive muscle stiffness (evaluated by angle-specific muscle
      shear modulus), tolerance to muscle stretch (evaluated by muscle shear modulus at
      end-ROM), and muscle slack angle of the triceps surae are associated with the
      individual variability and sex difference in dorsiflexion ROM, using ultrasound
      shear wave elastography. For men, ROM was negatively correlated to passive muscle
      stiffness of the medial and lateral gastrocnemius in a tensioned state and
      positively to tolerance to muscle stretch in the medial gastrocnemius. For women,
      ROM was only positively correlated to tolerance to muscle stretch in all muscles
      but not correlated to passive muscle stiffness. Muscle slack angle was not
      correlated to ROM in men and women. Significant sex differences were observed
      only for dorsiflexion ROM and passive muscle stiffness in a tensioned state.
      These findings suggest that muscular factors associated with ROM are different
      between men and women. Furthermore, the sex difference in dorsiflexion ROM might
      be attributed partly to that in passive muscle stiffness of plantar flexors.

PMID- 29844514
TI  - Characterization of Papaya ringspot virus isolates infecting transgenic papaya
      'Huanong No.1' in South China.
AB  - In 2006, the release and cultivation of the genetically modified papaya cultivar
      'Huanong No.1' successfully controlled the destructive papaya ringspot disease
      caused by Papaya ringspot virus (PRSV) in South China. However, some transgenic
      papaya plants from Guangdong and Hainan are found infected by PRSV. In this
      study, Field investigation was carried out and susceptible transgenic papaya
      samples were collected during 2012-2016. Twenty representative isolates were
      artificially inoculated into Cucurbita pepo and commercialised 'Huanong No.1'
      papaya, and results indicated that the plants showed obvious disease symptoms.
      Phylogenetic analysis of CP genes of 120 PRSV-infected isolates showed that PRSV
      can be divided into three groups. Isolates from Guangdong and Hainan belong to
      Group III, which is further divided into two subgroups. The isolates collected in
      this study have greatly diverged from the previously reported dominant strains
      Ys, Vb and Sm in South China, indicating that they belong to a new lineage.
      Further analysis showed a highly genetic differentiation between isolates, and
      27.1% of the isolates were identified as recombinants on the basis of CP
      nucleotide sequences. These results indicate that the genetic variation of PRSV
      and the formation of the new virus lineage may explain the loss of transgenic
      papaya resistance in South China.

PMID- 29844515
TI  - Caldera unrest driven by CO2-induced drying of the deep hydrothermal system.
AB  - Interpreting volcanic unrest is a highly challenging and non-unique problem at
      calderas, since large hydrothermal systems may either hide or amplify the
      dynamics of buried magma(s). Here we use the exceptional ground displacement and
      geochemical datasets from the actively degassing Campi Flegrei caldera (Southern
      Italy) to show that ambiguities disappear when the thermal evolution of the deep
      hydrothermal system is accurately tracked. By using temperatures from the CO2-CH4
      exchange of 13C and thermodynamic analysis of gas ascending in the crust, we
      demonstrate that after the last 1982-84 crisis the deep hydrothermal system
      evolved through supercritical conditions under the continuous isenthalpic inflow
      of hot CO2-rich gases released from the deep (~8 km) magma reservoir of regional
      size. This resulted in the drying of the base of the hot hydrothermal system, no
      more buffered along the liquid-vapour equilibrium, and excludes any shallow
      arrival of new magma, whose abundant steam degassing due to decompression would
      have restored liquid-vapour equilibrium. The consequent CO2-infiltration and
      progressive heating of the surrounding deforming rock volume cause the build-up
      of pore pressure in aquifers, and generate the striking temporal symmetry that
      characterizes the ongoing uplift and the post-1984 subsidence, both originated by
      the same but reversed deformation mechanism.

PMID- 29844516
TI  - A novel concept for dynamic adjustment of auditory space.
AB  - Traditionally, the auditory system is thought to serve reliable sound
      localization. Stimulus-history driven feedback circuits in the early binaural
      pathway, however, contradict this canonical concept and raise questions about
      their functional significance. Here we show that stimulus-history dependent
      changes in absolute space perception are poorly captured by the traditional
      labeled-line and hemispheric-difference models of auditory space coding. We
      therefore developed a new decoding model incorporating recent
      electrophysiological findings in which sound location is initially computed in
      both brain hemispheres independently and combined to yield a hemispherically
      balanced code. This model closely captures the observed absolute localization
      errors caused by stimulus history, and furthermore predicts a selective dilation
      and compression of perceptional space. These model predictions are confirmed by
      improvement and degradation of spatial resolution in human listeners. Thus,
      dynamic perception of auditory space facilitates focal sound source segregation
      at the expense of absolute sound localization, questioning existing concepts of
      spatial hearing.

PMID- 29844517
TI  - Beta and gamma human papillomaviruses in anal and genital sites among men:
      prevalence and determinants.
AB  - Data regarding the anogenital distribution of and type-specific concordance for
      cutaneous beta- and gamma-HPV types in men who have sex with women is limited and
      geographically narrow. Knowledge of determinants of anogenital detection of
      cutaneous HPV types in different regions is needed for better understanding of
      the natural history and transmission dynamics of HPV, and its potential role in
      the development of anogenital diseases. Genital and anal canal samples obtained
      from 554 Russian men were screened for 43 beta-HPVs and 29 gamma-HPVs, using a
      multiplex PCR combined with Luminex technology. Both beta- and gamma-HPVs were
      more prevalent in the anal (22.8% and 14.1%) samples than in the genital (16.8%
      and 12.3%) samples. Low overall and type-specific concordance for beta-HPVs (3.5%
      and 1.1%) and gamma-HPVs (1.3% and 0.6%) were observed between genital and anal
      samples. HIV-positive men had higher anal beta- (crude OR = 12.2, 95% CI: 5.3
      28.1) and gamma-HPV (crude OR = 7.2, 95% CI: 3.3-15.4) prevalence than HIV
      negative men. Due to the lack of genital samples from the HIV-positive men, no
      comparison was possible for HIV status in genital samples. The lack of type
      specific positive concordance between genital and anal sites for cutaneous beta-
      and gamma-HPV types in heterosexual men posits the needs for further studies on
      transmission routes to discriminate between contamination and true HPV infection.
      HIV-positive status may favor the anal acquisition or modify the natural history
      of cutaneous HPV types.

PMID- 29844518
TI  - PCR-Stop analysis as a new tool for qPCR assay validation.
AB  - Progressively more qPCR assays have been developed in recent years in numerous
      fields of application. These assays are routinely validated using calibration
      curves, but essential validation per se such as Poisson analysis is frequently
      neglected. However, validation is crucial for determination of resolution and
      quantitative and qualitative limits. The new test method PCR-Stop analysis
      presented in this work investigates assay performance during initial qPCR cycles.
      PCRs with one to five pre-runs are performed while the subsequent main qPCR runs
      reflect pre-run replication rates. Ideally, DNA doubles according to pre-runs,
      there is no variation between replicates and qPCR starts immediately at the first
      cycle with its average efficiency. This study shows two exemplary qPCR assays,
      both with suitable calibration curves and efficiencies. We demonstrated thereby
      the benefits of PCR-Stop analysis revealing quantitative and qualitative
      resolution of both assays, the limits of one of those assays and thus avoiding
      misinterpretations in qPCR analysis. Furthermore, data displayed that a well
      performing assay starts indeed with its average efficiency.

PMID- 29844519
TI  - Pneumocystis jirovecii pneumonia in HIV-uninfected, rituximab treated non-Hodgkin
      lymphoma patients.
AB  - Rituximab is associated with a higher incidence of Pneumocystis jirovecii
      pneumonia infection. Pneumocystis prophylaxis is advised in many
      immunocompromised populations treated with rituximab. However, the beneficial
      effect of pneumocystis prophylaxis in HIV-uninfected, rituximab-treated non
      Hodgkin lymphoma (NHL) patients has not been assessed. Thus, we conducted this
      retrospective study to explore pneumocystis infection in HIV-uninfected NHL
      patients who received at least three courses of chemotherapy without
      haematopoietic stem cell transplantation using the Taiwan National Health
      Insurance Research Database. Patients who had rituximab-based chemotherapy were
      included in the experimental (rituximab) group, while the rest of the patients
      who did not receive any rituximab-based chemotherapy throughout the study period
      formed the control group. The prevalence rate of pneumocystis infection in the
      rituximab group (N = 7,554) was significantly higher than that in the control
      group (N = 4,604) (2.95% vs. 1.32%). The onset of pneumocystis infection occurred
      between 6 and 16 weeks after chemotherapy. Patients who had pneumocystis
      prophylaxis, whether or not they had a pneumocystis infection later in their
      treatment course, had significantly better first-year survival rates (73% vs.
      38%). Regular pneumocystis prophylaxis should be considered in this group of
      patients.

PMID- 29844520
TI  - Generation and validation of homozygous fluorescent knock-in cells using CRISPR
      Cas9 genome editing.
AB  - Gene tagging with fluorescent proteins is essential for investigations of the
      dynamic properties of cellular proteins. CRISPR-Cas9 technology is a powerful
      tool for inserting fluorescent markers into all alleles of the gene of interest
      (GOI) and allows functionality and physiological expression of the fusion
      protein. It is essential to evaluate such genome-edited cell lines carefully in
      order to preclude off-target effects caused by (i) incorrect insertion of the
      fluorescent protein, (ii) perturbation of the fusion protein by the fluorescent
      proteins or (iii) nonspecific genomic DNA damage by CRISPR-Cas9. In this
      protocol, we provide a step-by-step description of our systematic pipeline to
      generate and validate homozygous fluorescent knock-in cell lines.We have used the
      paired Cas9D10A nickase approach to efficiently insert tags into specific genomic
      loci via homology-directed repair (HDR) with minimal off-target effects. It is
      time-consuming and costly to perform whole-genome sequencing of each cell clone
      to check for spontaneous genetic variations occurring in mammalian cell lines.
      Therefore, we have developed an efficient validation pipeline of the generated
      cell lines consisting of junction PCR, Southern blotting analysis, Sanger
      sequencing, microscopy, western blotting analysis and live-cell imaging for cell
      cycle dynamics. This protocol takes between 6 and 9 weeks. With this protocol, up
      to 70% of the targeted genes can be tagged homozygously with fluorescent
      proteins, thus resulting in physiological levels and phenotypically functional
      expression of the fusion proteins.

PMID- 29844521
TI  - In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue
      oxygenation in the mouse brain.
AB  - Cerebrovascular dysfunction has an important role in the pathogenesis of multiple
      brain disorders. Measurement of hemodynamic responses in vivo can be challenging,
      particularly as techniques are often not described in sufficient detail and vary
      between laboratories. We present a set of standardized in vivo protocols that
      describe high-resolution two-photon microscopy and intrinsic optical signal (IOS)
      imaging to evaluate capillary and arteriolar responses to a stimulus, regional
      hemodynamic responses, and oxygen delivery to the brain. The protocol also
      describes how to measure intrinsic NADH fluorescence to understand how blood O2
      supply meets the metabolic demands of activated brain tissue, and to perform
      resting-state absolute oxygen partial pressure (pO2) measurements of brain
      tissue. These methods can detect cerebrovascular changes at far higher resolution
      than MRI techniques, although the optical nature of these techniques limits their
      achievable imaging depths. Each individual procedure requires 1-2 h to complete,
      with two to three procedures typically performed per animal at a time. These
      protocols are broadly applicable in studies of cerebrovascular function in
      healthy and diseased brain in any of the existing mouse models of neurological
      and vascular disorders. All these procedures can be accomplished by a competent
      graduate student or experienced technician, except the two-photon measurement of
      absolute pO2 level, which is better suited to a more experienced, postdoctoral
      level researcher.

PMID- 29844523
TI  - Quantitative mapping of fluorescently tagged cellular proteins using FCS
      calibrated four-dimensional imaging.
AB  - The ability to tag a protein at its endogenous locus with a fluorescent protein
      (FP) enables quantitative understanding of protein dynamics at the physiological
      level. Genome-editing technology has now made this powerful approach routinely
      applicable to mammalian cells and many other model systems, thereby opening up
      the possibility to systematically and quantitatively map the cellular proteome in
      four dimensions. 3D time-lapse confocal microscopy (4D imaging) is an essential
      tool for investigating spatial and temporal protein dynamics; however, it lacks
      the required quantitative power to make the kind of absolute and comparable
      measurements required for systems analysis. In contrast, fluorescence correlation
      spectroscopy (FCS) provides quantitative proteomic and biophysical parameters
      such as protein concentration, hydrodynamic radius, and oligomerization but lacks
      the capability for high-throughput application in 4D spatial and temporal
      imaging. Here we present an automated experimental and computational workflow
      that integrates both methods and delivers quantitative 4D imaging data in high
      throughput. These data are processed to yield a calibration curve relating the
      fluorescence intensities (FIs) of image voxels to the absolute protein abundance.
      The calibration curve allows the conversion of the arbitrary FIs to protein
      amounts for all voxels of 4D imaging stacks. Using our workflow, users can
      acquire and analyze hundreds of FCS-calibrated image series to map their proteins
      of interest in four dimensions. Compared with other protocols, the current
      protocol does not require additional calibration standards and provides an
      automated acquisition pipeline for FCS and imaging data. The protocol can be
      completed in 1 d.

PMID- 29844522
TI  - Revealing the architecture of protein complexes by an orthogonal approach
      combining HDXMS, CXMS, and disulfide trapping.
AB  - Many cellular functions necessitate structural assemblies of two or more
      associated proteins. The structural characterization of protein complexes using
      standard methods, such as X-ray crystallography, is challenging. Herein, we
      describe an orthogonal approach using hydrogen-deuterium-exchange mass
      spectrometry (HDXMS), cross-linking mass spectrometry (CXMS), and disulfide
      trapping to map interactions within protein complexes. HDXMS measures changes in
      solvent accessibility and hydrogen bonding upon complex formation; a decrease in
      HDX rate could account for newly formed intermolecular or intramolecular
      interactions. To distinguish between inter- and intramolecular interactions, we
      use a CXMS method to determine the position of direct interface regions by
      trapping intermolecular residues in close proximity to various cross-linkers
      (e.g., disuccinimidyl adipate (DSA)) of different lengths and reactive groups.
      Both MS-based experiments are performed on high-resolution mass spectrometers
      (e.g., an Orbitrap Elite hybrid mass spectrometer). The physiological relevance
      of the interactions identified through HDXMS and CXMS is investigated by
      transiently co-expressing cysteine mutant pairs, one mutant on each protein at
      the discovered interfaces, in an appropriate cell line, such as HEK293. Disulfide
      trapped protein complexes are formed within cells spontaneously or are
      facilitated by addition of oxidation reagents such as H2O2 or diamide. Western
      blotting analysis, in the presence and absence of reducing reagents, is used to
      determine whether the disulfide bonds are formed in the proposed complex
      interface in physiologically relevant milieus. The procedure described here
      requires 1-2 months. We demonstrate this approach using the beta2-adrenergic
      receptor-beta-arrestin1 complex as the model system.

PMID- 29844524
TI  - High-throughput microsphiltration to assess red blood cell deformability and
      screen for malaria transmission-blocking drugs.
AB  - The mechanical retention of rigid erythrocytes in the spleen is central in major
      hematological diseases such as hereditary spherocytosis, sickle-cell disease and
      malaria. Here, we describe the use of microsphiltration (microsphere filtration)
      to assess erythrocyte deformability in hundreds to thousands of samples in
      parallel, by filtering them through microsphere layers in 384-well plates adapted
      for the discovery of compounds that stiffen Plasmodium falciparum gametocytes,
      with the aim of interrupting malaria transmission. Compound-exposed gametocytes
      are loaded into microsphiltration plates, filtered and then transferred to
      imaging plates for analysis. High-content imaging detects viable gametocytes
      upstream and downstream from filters and quantifies spleen-like retention. This
      screening assay takes 3-4 d. Unlike currently available methods used to assess
      red blood cell (RBC) deformability, microsphiltration enables high-throughput
      pharmacological screening (tens of thousands of compounds tested in a matter of
      months) and involves a cell mechanical challenge that induces a physiologically
      relevant dumbbell-shape deformation. It therefore directly assesses the ability
      of RBCs to cross inter-endothelial splenic slits in vivo. This protocol has
      potential applications in quality control for transfusion and in determination of
      phenotypic markers of erythrocytes in hematological diseases.

PMID- 29844525
TI  - Copy-number analysis and inference of subclonal populations in cancer genomes
      using Sclust.
AB  - The genomes of cancer cells constantly change during pathogenesis. This
      evolutionary process can lead to the emergence of drug-resistant mutations in
      subclonal populations, which can hinder therapeutic intervention in patients.
      Data derived from massively parallel sequencing can be used to infer these
      subclonal populations using tumor-specific point mutations. The accurate
      determination of copy-number changes and tumor impurity is necessary to reliably
      infer subclonal populations by mutational clustering. This protocol describes how
      to use Sclust, a copy-number analysis method with a recently developed mutational
      clustering approach. In a series of simulations and comparisons with alternative
      methods, we have previously shown that Sclust accurately determines copy-number
      states and subclonal populations. Performance tests show that the method is
      computationally efficient, with copy-number analysis and mutational clustering
      taking <10 min. Sclust is designed such that even non-experts in computational
      biology or bioinformatics with basic knowledge of the Linux/Unix command-line
      syntax should be able to carry out analyses of subclonal populations.

PMID- 29844526
TI  - Guiding biomedical clustering with ClustEval.
AB  - Clustering is a popular technique for discovering groups of similar objects in
      large datasets. It is nowadays applied in all areas of life sciences, from
      biomedicine to physics. However, designing high-quality cluster analyses is a
      tedious and complicated task with manifold choices along the way. As a cluster
      analysis is often the first step of a succeeding downstream analysis, the
      clustering must be reliable, reproducible, and of the highest quality. To address
      these challenges, we recently developed ClustEval, an integrated and extensible
      platform for the automated and standardized design and execution of complex
      cluster analyses. It allows researchers to design and carry out cluster analyses
      involving a large number of clustering methods applied to many, large datasets.
      ClustEval helps to shed light on all major aspects of cluster analysis, from
      choosing the right similarity function to using validity indices and data
      preprocessing protocols. Only this high degree of automation allows the
      researcher to easily run a clustering task with many different tools, parameters,
      and settings in order to gain the best possible outcome. In this paper, we guide
      the user step by step through three fundamentally important and widely applicable
      use cases: (i) identification of the best clustering method for a new, user-given
      protein sequence similarity dataset; (ii) evaluation of the performance of a new,
      user-given clustering method (densityCut) against the state of the art; and (iii)
      prediction of the best method for a new protein sequence similarity dataset. This
      protocol guides the user through the most important features of ClustEval and
      takes ~4 h to complete.

PMID- 29844527
TI  - Novel Dual-band Band-Pass Filters Based on Surface Plasmon Polariton-like
      Propagation Induced by Structural Dispersion of Substrate Integrated Waveguide.
AB  - In this paper, we present two novel dual-band bandpass filters based on surface
      plasmon polariton-like (SPP-like) propagation induced by structural dispersion of
      substrate integrated waveguide (SIW). Both filters are realized as a three-layer
      SIW where each layer represents a sub-SIW structure with intrinsic effective
      permittivity that depends on its width and filling dielectric material. The
      layers are designed to have effective permittivities of opposite signs in certain
      frequency ranges, which enables SPP-like propagation to occur at their
      interfaces. Since three layers can provide two distinct SPP-like propagations,
      the filters exhibit dual-band behaviour. A detailed theoretical and numerical
      analysis and numerical optimization have been used to design the filters, which
      were afterwards fabricated using standard printed circuit board technology. The
      independent choice of geometrical parameters of sub-SIWs and/or the corresponding
      dielectric materials provide a great freedom to arbitrarily position the
      passbands in the spectrum, which is a significant advantage of the proposed
      filters. At the same time, they meet the requirements for low-cost low-profile
      configuration since they are realized as SIW structures, as well as for excellent
      in-band characteristics and selectivity which is confirmed by the measurement
      results.

PMID- 29844528
TI  - Impact of genetics on third molar agenesis.
AB  - The purpose of this investigation was to determine the impact of heritability on
      third molar agenesis in twins. The study sample consisted of 284 same sex twins
      (172 monozygotic and 112 dizygotic), whose mean ages were 19.7 +/- 4.3 and 18.9
      +/- 4.8 years, respectively. The monozygotic group consisted of 36.3% males and
      63.7% females, while the dizygotic group consisted of 50.1% males and 49.9%
      females. The zygosity of the twins was established using 15 specific DNA markers.
      The prevalence of third molar agenesis in monozygotic twins was 19.6%, which was
      higher than in the dizygotic twins group (15.50%) (p = 0.004). In both groups,
      third molar agenesis was more frequent in the maxilla than in the mandible (p =
      0.000). Agenesis of the maxillary third molars was mostly affected by additive
      genetic factors (62-63%), with the common environment and the specific
      environment accounting for up to 25% and 13%, respectively. In contrast, agenesis
      of the lower third molars was associated with a higher additive genetic
      determination (81-83%), with the specific environment accounting for 17% to 19%.
      The study's conclusion is that the formation of the third molars follicle is
      strongly controlled by additive genetic factors.

PMID- 29844529
TI  - Daily morning light therapy is associated with an increase in choroidal thickness
      in healthy young adults.
AB  - Ambient light exposure is one environmental factor thought to play a role in the
      regulation of eye growth and refractive error development, and choroidal
      thickness changes have also been linked to longer term changes in eye growth.
      Therefore in this study we aimed to examine the influence of a 1-week period of
      morning light therapy upon choroidal thickness. Twenty two healthy young adult
      subjects had a series of macular choroidal thickness measurements collected with
      spectral domain optical coherence tomography before, and then following a 7-day
      period of increased daily light exposure. Increased light exposure was delivered
      through the use of commercially available light therapy glasses, worn for 30
      minutes in the morning each day. A significant increase in subfoveal choroidal
      thickness (mean increase of +5.4 +/- 10.3 um) was found following 7-days of
      increased daily light exposure (p = 0.02). An increase in choroidal thickness was
      also observed associated with light therapy across the central 5 mm macular
      region. This study provides the first evidence in the human eye that daily
      morning light therapy results in small magnitude but statistically significant
      increases in choroidal thickness. These changes may have implications for our
      understanding of the impact of environmental factors upon eye growth.

PMID- 29844530
TI  - A non-invasive approach to estimate the energetic requirements of an increasing
      seabird population in a perturbed marine ecosystem.
AB  - There is a growing desire to integrate the food requirements of predators living
      in marine ecosystems impacted by humans into sustainable fisheries management. We
      used non-invasive video-recording, photography and focal observations to build
      time-energy budget models and to directly estimate the fish mass delivered to
      chicks by adult greater crested terns Thalasseus bergii breeding in the Benguela
      ecosystem. Mean modelled adult daily food intake increased from 140.9 g.d-1 of
      anchovy Engraulis capensis during incubation to 171.7 g.d-1 and 189.2 g.d-1 when
      provisioning small and large chicks, respectively. Modelled prey intake expected
      to be returned to chicks was 58.3 g.d-1 (95% credible intervals: 44.9-75.8 g.d-1)
      over the entire growth period. Based on our observations, chicks were fed 19.9
      g.d-1 (17.2-23.0 g.d-1) to 45.1 g.d-1 (34.6-58.7 g.d-1) of anchovy during early
      and late provisioning, respectively. Greater crested terns have lower energetic
      requirements at the individual (range: 15-34%) and population level (range: 1-7%)
      than the other Benguela endemic seabirds that feed on forage fish. These modest
      requirements - based on a small body size and low flight costs - coupled with
      foraging plasticity have allowed greater crested terns to cope with changing prey
      availability, unlike the other seabirds species using the same exploited prey
      base.

PMID- 29844532
TI  - Optimization of Transcranial Direct Current Stimulation of Dorsolateral
      Prefrontal Cortex for Tinnitus: A Non-Linear Dose-Response Effect.
AB  - Neuromodulation is defined as the process of augmenting neuroplasticity via
      invasive or non-invasive methods. Tinnitus is the perception of sound in the
      absence of its external source. The objective of this study was to optimize the
      parameters of transcranial direct current stimulation (tDCS) of dorsolateral
      prefrontal cortex (DLPFC) for tinnitus suppression. The following factors were
      optimized in the dose-response design (n = 111): current intensity (1.5 mA or 2
      mA), stimulation duration (20 min or 30 min), and number of stimulation sessions
      (2, 4, 6, 8, or 10), with a 3-4 day washout period between each session.
      Participants underwent a minimum of 2 sessions in 1 week or maximum of 10
      sessions in 5 weeks' time. Tinnitus loudness was measured in pre-post design
      using a 10-point numeric rating scale. There was a significant reduction in
      tinnitus loudness after tDCS of DLPFC. There was no significant difference
      between the intensity and duration of stimulation. As the number of sessions
      increased, there was a higher reduction in the tinnitus loudness; however, this
      effect plateaued after 6 sessions.

PMID- 29844531
TI  - A qualitative proteome-wide lysine crotonylation profiling of papaya (Carica
      papaya L.).
AB  - Lysine crotonylation of histone proteins is a recently-identified post
      translational modification with multiple cellular functions. However, no
      information about lysine crotonylation of non-histone proteins in fruit cells is
      available. Using high-resolution LC-MS/MS coupled with highly sensitive immune
      affinity antibody analysis, a global crotonylation proteome analysis of papaya
      fruit (Carica papaya L.) was performed. In total, 2,120 proteins with 5,995
      lysine crotonylation sites were discovered, among which eight conserved motifs
      were identified. Bioinformatic analysis linked crotonylated proteins to multiple
      metabolic pathways, including biosynthesis of antibiotics, carbon metabolism,
      biosynthesis of amino acids, and glycolysis. particularly, 40 crotonylated
      enzymes involved in various pathways of amino acid metabolism were identified,
      suggesting a potential conserved function for crotonylation in the regulation of
      amino acid metabolism. Numerous crotonylation sites were identified in proteins
      involved in the hormone signaling and cell wall-related pathways. Our
      comprehensive crotonylation proteome indicated diverse functions for lysine
      crotonylation in papaya.

PMID- 29844533
TI  - Quantum entanglement of a harmonic oscillator with an electromagnetic field.
AB  - At present, there are many methods for obtaining quantum entanglement of
      particles with an electromagnetic field. Most methods have a low probability of
      quantum entanglement and not an exact theoretical apparatus based on an
      approximate solution of the Schrodinger equation. There is a need for new methods
      for obtaining quantum-entangled particles and mathematically accurate studies of
      such methods. In this paper, a quantum harmonic oscillator (for example, an
      electron in a magnetic field) interacting with a quantized electromagnetic field
      is considered. Based on the exact solution of the Schrodinger equation for this
      system, it is shown that for certain parameters there can be a large quantum
      entanglement between the electron and the electromagnetic field. Quantum
      entanglement is analyzed on the basis of a mathematically exact expression for
      the Schmidt modes and the Von Neumann entropy.

PMID- 29844534
TI  - Evaluation of psychological stress in confined environments using salivary, skin,
      and facial image parameters.
AB  - Detecting the influence of psychological stress is particularly important in
      prolonged space missions. In this study, we determined potential markers of
      psychological stress in a confined environment. We examined 23 Japanese subjects
      staying for 2 weeks in a confined facility at Tsukuba Space Center, measuring
      salivary, skin, and facial image parameters. Saliva was collected at four points
      in a single day to detect diurnal variation. Increases in salivary cortisol were
      detected after waking up on the 4th and 11th days, and at 15:30 on the 1st and in
      the second half of the stay. Transepidermal water loss (TEWL) and sebum content
      of the skin were higher compared with outside the facility on the 4th and 1st
      days respectively. Increased IL-1beta in the stripped stratum corneum was
      observed on the 14th day, and 7 days after leaving. Differences in facial
      expression symmetry at the time of facial expression changes were observed on
      11th and 14th days. Thus, we detected a transition of psychological stress using
      salivary cortisol profiles and skin physiological parameters. The results also
      suggested that IL-1beta in the stripped stratum corneum and facial expression
      symmetry are possible novel markers for conveniently detecting psychological
      stress.

PMID- 29844535
TI  - Responses to salinity stress in bivalves: Evidence of ontogenetic changes in
      energetic physiology on Cerastoderma edule.
AB  - Estuarine bivalves are especially susceptible to salinity fluctuations. Stage
      specific sensibilities may influence the structure and spatial distribution of
      the populations. Here we investigate differences on the energetic strategy of
      thread drifters (3-4 mm) and sedentary settlers (9-10 mm) of Cerastoderma edule
      over a wide range of salinities. Several physiological indicators (clearance,
      respiration and excretion rates, O:N) were measured during acute (2 days) and
      acclimated responses (7 days of exposure) for both size classes. Our results
      revealed a common lethal limit for both developmental stages (Salinity 15) but a
      larger physiological plasticity of thread drifters than sedentary settlers.
      Acclimation processes in drifters were initiated after 2 days of exposure and
      they achieved complete acclimation by day 7. Sedentary settlers delay acclimation
      and at day 7 feeding activity had not resumed and energetic losses through
      respiration and excretion were higher at the lowest salinity treatment. Different
      responses facing salinity stress might be related to differences in habitat of
      each stage. For sedentary settlers which occupy relatively stable niches, energy
      optimisation include delaying the initiation of the energetically expensive
      acclimation processes while drifters which occupy less stable environments
      require a more flexible process which allow them to optimize energy acquisition
      as fast as possible.

PMID- 29844536
TI  - Injectable cartilaginous template transformed BMSCs into vascularized bone.
AB  - Regeneration of alveolar bone for dental implant remains a major issue,
      partifcularly for patients suffering from severe bone adsorption and irregular
      socket trauma. Recapitulating embryological development is becoming an attractive
      approach for engineer organ or three-dimensional tissues from stem cells. In this
      study, we aimed to develop an injectable "cartilaginous" graft with adequate
      mechanical resistance and ideal bone remodelling potential. The cartilaginous
      graft was composed of a particulate decellularised cartilage matrix (PDCM),
      chondrogenically primed bone mesenchymal stem cell (BMSC) bricks (CB), and
      enriched platelet-rich plasma (P) gel. In immunodeficient mice, we found that
      angiogenesis occurred quickly inside PDCM-CB-P constructs after implantation,
      thereby improving tissue survival and bone formation. In rabbit tibia bone
      defects around implants, we confirmed that CBs not only transformed into bone
      tissue rapidly, but also significantly promoted bone remodelling and replacement
      of PDCM, thus realising osseointegration of dental implants within 3 months. In
      conclusion, CBs exhibited the potential for endochondral ossification in vivo,
      and application of a cartilaginous template composed of PDCM, CB, and P provided
      a minimally-invasive, "free material residual" approach to regenerate alveolar
      bone tissues in vivo. This method could have applications in peri-implant bone
      regeneration.

PMID- 29844537
TI  - Computing Mathematical Functions using DNA via Fractional Coding.
AB  - This paper discusses the implementation of mathematical functions such as
      exponentials, trigonometric functions, the sigmoid function and the perceptron
      function with molecular reactions in general, and DNA strand displacement
      reactions in particular. The molecular constructs for these functions are
      predicated on a novel representation for input and output values: a fractional
      encoding, in which values are represented by the relative concentrations of two
      molecular types, denoted as type-1 and type-0. This representation is inspired by
      a technique from digital electronic design, termed stochastic logic, in which
      values are represented by the probability of 1's in a stream of randomly
      generated 0's and 1's. Research in the electronic realm has shown that a variety
      of complex functions can be computed with remarkably simple circuitry with this
      stochastic approach. This paper demonstrates how stochastic electronic designs
      can be translated to molecular circuits. It presents molecular implementations of
      mathematical functions that are considerably more complex than any shown to date.
      All designs are validated using mass-action simulations of the chemical kinetics
      of DNA strand displacement reactions.

PMID- 29844538
TI  - Chytridiomycosis causes catastrophic organism-wide metabolic dysregulation
      including profound failure of cellular energy pathways.
AB  - Chytridiomycosis is among several recently emerged fungal diseases of wildlife
      that have caused decline or extinction of naive populations. Despite recent
      advances in understanding pathogenesis, host response to infection remains poorly
      understood. Here we modelled a total of 162 metabolites across skin and liver
      tissues of 61 frogs from four populations (three long-exposed and one naive to
      the fungus) of the Australian alpine tree frog (Litoria verreauxii alpina)
      throughout a longitudinal exposure experiment involving both infected and
      negative control individuals. We found that chytridiomycosis dramatically altered
      the organism-wide metabolism of clinically diseased frogs. Chytridiomycosis
      caused catastrophic failure of normal homeostatic mechanisms (interruption of
      biosynthetic and degradation metabolic pathways), and pronounced dysregulation of
      cellular energy metabolism. Key intermediates of the tricarboxylic acid cycle
      were markedly depleted, including in particular alpha-ketoglutarate and glutamate
      that together constitute a key nutrient pathway for immune processes. This study
      was the first to apply a non-targeted metabolomics approach to a fungal wildlife
      disease and specifically to dissect the host-pathogen interface of Bd-infected
      frogs. The patterns of metabolite accumulation we have identified reveal whole
      body metabolic dysfunction induced by a fungal skin infection, and these findings
      have broad relevance for other fungal diseases.

PMID- 29844539
TI  - Broad distribution spectrum from Gaussian to power law appears in stochastic
      variations in RNA-seq data.
AB  - Gene expression levels exhibit stochastic variations among genetically identical
      organisms under the same environmental conditions. In many recent transcriptome
      analyses based on RNA sequencing (RNA-seq), variations in gene expression levels
      among replicates were assumed to follow a negative binomial distribution,
      although the physiological basis of this assumption remains unclear. In this
      study, RNA-seq data were obtained from Arabidopsis thaliana under eight
      conditions (21-27 replicates), and the characteristics of gene-dependent
      empirical probability density function (ePDF) profiles of gene expression levels
      were analyzed. For A. thaliana and Saccharomyces cerevisiae, various types of
      ePDF of gene expression levels were obtained that were classified as Gaussian,
      power law-like containing a long tail, or intermediate. These ePDF profiles were
      well fitted with a Gauss-power mixing distribution function derived from a simple
      model of a stochastic transcriptional network containing a feedback loop. The
      fitting function suggested that gene expression levels with long-tailed ePDFs
      would be strongly influenced by feedback regulation. Furthermore, the features of
      gene expression levels are correlated with their functions, with the levels of
      essential genes tending to follow a Gaussian-like ePDF while those of genes
      encoding nucleic acid-binding proteins and transcription factors exhibit long
      tailed ePDF.

PMID- 29844540
TI  - Synchrotron radiation reveals the identity of the large felid from Monte
      Argentario (Early Pleistocene, Italy).
AB  - We describe here a partial skull with associated mandible of a large felid from
      Monte Argentario, Italy (Early Pleistocene; ~1.5 million years). Propagation x
      ray phase-contrast synchrotron microtomography of the specimen, still partially
      embedded in the rock matrix, allows ascribing it reliably to Acinonyx
      pardinensis, one of the most intriguing extinct carnivorans of the Old World Plio
      Pleistocene. The analysis of images and 3D models obtained through synchrotron
      microtomography - here applied for the first time on a Plio-Pleistocene
      carnivoran - reveals a mosaic of cheetah-like and Panthera-like features, with
      the latter justifying previous attributions of the fossil to the extinct Eurasian
      jaguar Panthera gombaszoegensis. Similarly, we reassign to A. pardinensis some
      other Italian materials previously referred to P. gombaszoegensis (sites of
      Pietrafitta and Ellera di Corciano). The recognition of Panthera-like characters
      in A. pardinensis leads to reconsidering the ecological role of this species,
      whose hunting strategy was likely to be different from those of the living
      cheetah. Furthermore, we hypothesise that the high intraspecific variation in
      body size in A. pardinensis can be the result of sexual dimorphism, as observed
      today in all large-sized felids.

PMID- 29844541
TI  - Effects of parental acclimation and energy limitation in response to high CO2
      exposure in Atlantic cod.
AB  - Ocean acidification (OA), the dissolution of excess anthropogenic carbon dioxide
      in ocean waters, is a potential stressor to many marine fish species. Whether
      species have the potential to acclimate and adapt to changes in the seawater
      carbonate chemistry is still largely unanswered. Simulation experiments across
      several generations are challenging for large commercially exploited species
      because of their long generation times. For Atlantic cod (Gadus morhua), we
      present first data on the effects of parental acclimation to elevated aquatic CO2
      on larval survival, a fundamental parameter determining population recruitment.
      The parental generation in this study was exposed to either ambient or elevated
      aquatic CO2 levels simulating end-of-century OA levels (~1100 uatm CO2) for six
      weeks prior to spawning. Upon fully reciprocal exposure of the F1 generation, we
      quantified larval survival, combined with two larval feeding regimes in order to
      investigate the potential effect of energy limitation. We found a significant
      reduction in larval survival at elevated CO2 that was partly compensated by
      parental acclimation to the same CO2 exposure. Such compensation was only
      observed in the treatment with high food availability. This complex 3-way
      interaction indicates that surplus metabolic resources need to be available to
      allow a transgenerational alleviation response to ocean acidification.

PMID- 29844542
TI  - The analysis of MSTMOVCF (Multi-segment thoracolumbar mild osteoporotic fractures
      surgery or conservative treatment) based on ASTLOF (the assessment system of
      thoracolumbar osteoporotic fracture).
AB  - To investigate the issue that conservative or surgical treatment for multi
      segmental thoracolumbar mild osteoporotic vertebral compression fracture
      (MSTMOVCF) by applying the assessment system of thoracolumbar osteoporotic
      fracture (ASTLOF). A single-center prospective cohort study was designed to
      enroll elderly patients with MSTMOVCF from June 2013 to June 2016, which were
      divided into conservative and surgery group. The primary outcomes were Visual
      Analogue Scale (VAS) score and Oswestry Disability Index (ODI) score, with
      secondary outcomes including SF-36 and imaging measures such as height of
      anterior and middle column, Beck value, complications. A total of 470 patients
      with MSTMOVCF were enrolled. 193 patients underwent surgery of percutaneous
      vertebroplasty (PVP) or percutaneous kyphoplasty (PKP) and 277 patients underwent
      conservative treatment. The VAS score of operation group was significantly lower
      than that of conservative group (P < 0.0001, for all). The ODI score of the
      operation group was significantly lower than that of conservative group (P <
      0.0001, for all). The SF-36 score, height of anterior and middle column, Beck
      value in the operation group were higher than those in conservative group (P <
      0.0001, for all) at 1-year follow-up. MSTMOVCF underwent surgery can achieve
      great short-term clinical results. The patient with the sum of revised ASTLOF
      scores of multiple injured vertebrae >= 5 was recommended for surgery.

PMID- 29844543
TI  - Share of African American men going into medicine hits historic low.

PMID- 29844544
TI  - Muons: the little-known particles helping to probe the impenetrable.

PMID- 29844545
TI  - Rush to protect lucrative antibody patents kicks into gear.

PMID- 29844546
TI  - Fifty years since DNA repair was linked to cancer.

PMID- 29844547
TI  - Money for nothing: the truth about universal basic income.

PMID- 29844548
TI  - Making physics more inclusive.

PMID- 29844550
TI  - Huntington's disease.

PMID- 29844549
TI  - CRISPR takes on Huntington's disease.

PMID- 29844551
TI  - Living under the shadow of Huntington's disease.

PMID- 29844552
TI  - Piecing together the puzzle of Huntington's disease.

PMID- 29844553
TI  - When Huntington's disease comes early.

PMID- 29844554
TI  - Improved metrics for Huntington's disease trials.

PMID- 29844555
TI  - Huntington's disease: 4 big questions.

PMID- 29844556
TI  - How the gene behind Huntington's disease could be neutralized.

PMID- 29844557
TI  - The zest of Zhejiang.

PMID- 29844562
TI  - Brexit uncertainty threatens fusion-energy research.

PMID- 29844563
TI  - 'Reprogrammed' stem cells approved to mend human hearts for the first time.

PMID- 29844564
TI  - Stem-cell tests must show success.

PMID- 29844565
TI  - MicroRNA Expression Profiling in the Prefrontal Cortex: Putative Mechanisms for
      the Cognitive Effects of Adolescent High Fat Feeding.
AB  - The medial prefrontal cortex (mPFC), master regulator of higher-order cognitive
      functions, is the only brain region that matures until late adolescence. During
      this period, the mPFC is sensitive to stressful events or suboptimal nutrition.
      For instance, high-fat diet (HFD) feeding during adolescence markedly impairs
      prefrontal-dependent cognition. It also provokes multiple changes at the cellular
      and synaptic scales within the mPFC, suggesting that major transcriptional events
      are elicited by HFD during this maturational period. The nature of this
      transcriptional reprogramming remains unknown, but may include epigenetic
      processes, in particular microRNAs, known to directly regulate synaptic
      functions. We used high-throughput screening in the adolescent mouse mPFC and
      identified 38 microRNAs differentially regulated by HFD, in particular mir-30e
      5p. We used a luciferase assay to confirm the functional effect of mir-30e-5p on
      a chosen target: Ephrin-A3. Using global pathway analyses of predicted microRNA
      targets, we identified biological pathways putatively affected by HFD. Axon
      guidance was the top-1 pathway, validated by identifying gene expression changes
      of axon guidance molecules following HFD. Our findings delineate major microRNA
      transcriptional reprogramming within the mPFC induced by adolescent HFD. These
      results will help understanding the contribution of microRNAs in the emergence of
      cognitive deficits following early-life environmental events.

PMID- 29844567
TI  - The Usage of Exon-Exon Splice Junctions for the Detection of Alternative Splicing
      using the REIDS model.
AB  - Alternative gene splicing is a common phenomenon in which a single gene gives
      rise to multiple transcript isoforms. The process is strictly guided and involves
      a multitude of proteins and regulatory complexes. Unfortunately, aberrant
      splicing events have been linked to genetic disorders. Therefore, understanding
      mechanisms of alternative splicing regulation and differences in splicing events
      between diseased and healthy tissues is crucial in advancing personalized
      medicine and drug developments. We propose a linear mixed model, Random Effects
      for the Identification of Differential Splicing (REIDS), for the identification
      of alternative splicing events using Human Transcriptome Arrays (HTA). For each
      exon, a splicing score is calculated based on two scores, an exon score and an
      array score. The junction information is used to rank the identified exons from
      strongly confident to less confident candidates for alternative splicing. The
      design of junctions was also discussed to highlight the complexity of exon-exon
      and exon-junction interactions. Based on a list of Rt-PCR validated probe sets,
      REIDS outperforms AltAnalyze and iGems in the % recall rate.

PMID- 29844568
TI  - Oxeiptosis-a cell death pathway to mitigate damage caused by radicals.

PMID- 29844569
TI  - Is oxidative stress MYC's Achilles heel?

PMID- 29844570
TI  - An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR
      204 promotes the invasion and metastasis of triple-negative breast cancer.
AB  - Androgen receptor (AR) is emerging as a novel prognostic biomarker in triple
      negative breast cancer (TNBC), but the underlying mechanisms remain unknown. As
      accumulating evidence has shown that long non-coding RNAs (lncRNAs) regulate
      important cancer hallmarks, we hypothesised that AR-regulated lncRNAs might play
      roles in TNBC progression. Here, we performed experiments with or without DHT
      treatment in three TNBC cell lines, and we identified an AR negatively induced
      lncRNA (ARNILA), which correlated with poor progression-free survival (PFS) in
      TNBC patients and promoted epithelial-mesenchymal transition (EMT), invasion and
      metastasis in vitro and in vivo. Subsequently, we demonstrated that ARNILA
      functioned as a competing endogenous RNA (ceRNA) for miR-204 to facilitate
      expression of its target gene Sox4, which is known to induce EMT and contribute
      to breast cancer progression, thereby promoting EMT, invasion and metastasis of
      TNBC. Our findings not only provide new insights into the mechanisms of lncRNA in
      regulating AR but also suggest ARNILA as an alternative therapeutic target to
      suppress metastasis of TNBC patients.

PMID- 29844571
TI  - Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation
      and cancer stem cells in prostate.
AB  - Monoamine oxidase A (MAOA) is a mitochondrial enzyme, which degrades monoamine
      neurotransmitters and dietary amines and produces H2O2. Recent studies have shown
      increased MAOA expression in prostate cancer (PCa), glioma, and classical Hodgkin
      lymphoma. However, the biological function of MAOA in cancer development remains
      unknown. In this study, we investigated the role of MAOA in the development of
      prostate adenocarcinoma by creating a prostate-specific Pten/MAOA knockout (KO)
      mouse model, in which MAOA-floxP mouse was crossed with the conditional Pten KO
      PCa mouse that develops invasive PCa. In contrast to Pten KO mice, age-matched
      Pten/MAOA KO mice exhibited a significant decrease in both prostate size and the
      incidence of invasive cancer. We observed a significant decline in AKT
      phosphorylation and Ki67 expression in Pten/MAOA KO mice, which reduced
      epithelial cell growth and proliferation. As cancer stem cells (CSCs) are
      required for tumor initiation and growth, we investigated expression of OCT4 and
      NANOG in the setting of decreased MAOA expression. We found that both OCT4 and
      NANOG were significantly attenuated in the prostate epithelia of Pten/MAOA KO
      mice compared to Pten KO mice, which was confirmed with targeted knockdown of
      MAOA with a short-hairpin(sh) vector targeting MAOA compared to cells transfected
      with a control vector. Expression of other markers associated with the a stem
      cell phenotype, including CD44, alpha2beta1, and CD133 as well as HIF
      1alpha+CD44+ stem cells were all decreased in shMAOA PCa cells compared with
      empty vector-transfected control cells. We also found spheroid formation ability
      in PCa cells was decreased when endogenous MAOA was suppressed by siRNA or MAOA
      inhibitor clorgyline in a colony formation assay. Using the TCGA database,
      elevated MAOA expression was associated with reduced Pten levels in high Gleason
      grade in patient samples. Further, we found that Pten-positive PCa cells were
      more resistant to clorgyline treatments than Pten-null cells in tumorigenicity
      and stemness. Taken together, these studies suggest that MAOA expression promotes
      PCa development by increasing cell proliferation and CSCs and highlights the
      potential use of MAOA inhibitors for the treatment of PCa.

PMID- 29844572
TI  - RANK-c attenuates aggressive properties of ER-negative breast cancer by
      inhibiting NF-kappaB activation and EGFR signaling.
AB  - The RANK/RANKL axis emerges as a key regulator of breast cancer initiation,
      progression, and metastasis. RANK-c is a RANK receptor isoform produced through
      alternative splicing of the TNFRSF11A (RANK) gene and a dominant-negative
      regulator of RANK-induced nuclear factor-kappaB (NF-kappaB) activation. Here we
      report that RANK-c transcript is expressed in 3.2% of cases in The Cancer Genome
      Atlas breast cancer cohort evenly between ER-positive and ER-negative cases.
      Nevertheless, the ratio of RANK to RANK-c (RANK/RANK-c) is increased in ER
      negative breast cancer cell lines compared to ER-positive breast cancer cell
      lines. In addition, forced expression of RANK-c in ER-negative breast cancer cell
      lines inhibited stimuli-induced NF-kappaB activation and attenuated migration,
      invasion, colony formation, and adhesion of cancer cells. Further, RANK-c
      expression in MDA-MB-231 cells inhibited lung metastasis and colonization in
      vivo. The RANK-c-mediated inhibition of cancer cell aggressiveness and nuclear
      factor-kappaB (NF-kappaB) activation in breast cancer cells seems to rely on a
      RANK-c/TNF receptor-associated factor-2 (TRAF2) protein interaction. This was
      further confirmed by a mutated RANK-c that is unable to interact with TRAF2 and
      abolishes the ability to attenuate NF-kappaB activation, migration, and invasion.
      Additional protein interaction characterization revealed epidermal growth factor
      receptor (EGFR) as a novel interacting partner for RANK-c in breast cancer cells
      with a negative effect on EGFR phosphorylation and EGF-dependent downstream
      signaling pathway activation. Our findings further elucidate the complex
      molecular biology of the RANKL/RANK system in breast cancer and provide
      preliminary data for RANK-c as a possible marker for disease progression and
      aggressiveness.

PMID- 29844566
TI  - Study of 300,486 individuals identifies 148 independent genetic loci influencing
      general cognitive function.
AB  - General cognitive function is a prominent and relatively stable human trait that
      is associated with many important life outcomes. We combine cognitive and genetic
      data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age
      16-102) and find 148 genome-wide significant independent loci (P < 5 * 10-8)
      associated with general cognitive function. Within the novel genetic loci are
      variants associated with neurodegenerative and neurodevelopmental disorders,
      physical and psychiatric illnesses, and brain structure. Gene-based analyses find
      709 genes associated with general cognitive function. Expression levels across
      the cortex are associated with general cognitive function. Using polygenic
      scores, up to 4.3% of variance in general cognitive function is predicted in
      independent samples. We detect significant genetic overlap between general
      cognitive function, reaction time, and many health variables including eyesight,
      hypertension, and longevity. In conclusion we identify novel genetic loci and
      pathways contributing to the heritability of general cognitive function.

PMID- 29844573
TI  - Melanoma protective antitumor immunity activated by catalytic DNA.
AB  - Melanoma incidence is increasing worldwide, and although drugs such as BRAF/MEK
      small-molecule inhibitors and immune checkpoint antibodies improve patient
      outcomes, most patients ultimately fail these therapies and alternative treatment
      strategies are urgently needed. DNAzymes have recently undergone clinical trials
      with signs of efficacy and no serious adverse events attributable to the DNAzyme.
      Here we investigated c-Jun expression in human primary and metastatic melanoma.
      We also explored the role of T cell immunity in DNAzyme inhibition of primary
      melanoma growth and the prevention of growth in non-treated tumors after the
      cessation of treatment in a mouse model. c-Jun was expressed in 80% of melanoma
      cells in human primary melanomas (n = 17) and in 83% of metastatic melanoma cells
      (n = 38). In contrast, c-Jun was expressed in only 11% of melanocytes in benign
      nevi (n = 24). Dz13, a DNAzyme targeting c-Jun/AP-1, suppressed both Dz13
      injected and untreated B16F10 melanoma growth in the same mice, an abscopal
      effect relieved in each case by administration of anti-CD4/anti-CD8 antibodies.
      Dz13 increased levels of cleaved caspase-3 within the tumors. New, untreated
      melanomas grew poorly in mice previously treated with Dz13. Administration of
      anti-CD4/anti-CD8 antibodies ablated this inhibitory effect and the tumors grew
      rapidly. Dz13 inhibited c-Jun expression, reduced intratumoral vascularity
      (vascular lumina area defined by CD31 staining), and increased CD4+ cells within
      the tumors. This study provides the first demonstration of an abscopal effect of
      a DNAzyme on tumor growth and shows that Dz13 treatment prevents growth of
      subsequent new tumors in the same animal. Dz13 may be useful clinically as a
      therapeutic antitumor agent by preventing tumor relapse through adaptive
      immunity.

PMID- 29844574
TI  - Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense.
AB  - Mammalian cells are equipped with antiviral innate immunity. To survive and grow,
      human papilloma virus (HPV)-infected cervical cancer cells must overcome this
      host defense system. However, the precise mechanism whereby cervical cancer cells
      evade the immunity is not fully understood. We noted that Sirtuin 1 (SIRT1) is
      overexpressed in HPV-infected cervical cancer cells and hypothesized that SIRT1
      counteracts antiviral immunity. Here, we found that cervical cancer cells undergo
      massive death by SIRT1 knockdown, but this effect is reversed by SIRT1
      restoration. SIRT1-knocked-down cells showed representative features of
      pyroptosis, as well as highly expressed absent in melanoma 2 (AIM2) and its
      downstream genes related to the inflammasome response. Mechanistically, SIRT1
      repressed the NF-kappaB-driven transcription of the AIM2 gene by destabilizing
      the RELB mRNA. Interestingly, pyroptotic death signaling in SIRT1-knocked-down
      cells was transmitted to naive cervical cancer cells, which was mediated by
      extracellular vesicles carrying AIM2 inflammasome proteins. Furthermore, the
      growth of cervical cancer xenografts was significantly inhibited by either SIRT1
      targeting siRNAs or SIRT1-knockdown-derived extracellular vesicles.
      Immunohistochemical analyses showed that SIRT1 expression correlated with poor
      clinical outcomes in cervical cancer. In conclusion, SIRT1 enabled HPV-infected
      cervical cancer cells to continue growing by nullifying AIM2 inflammasome
      mediated immunity. Without SIRT1, cervical cancer cells could no longer survive
      because of the derepression of the AIM2 inflammasome. SIRT1 could therefore be a
      target for the effective treatment of cervical cancer.

PMID- 29844575
TI  - Conformation and dynamics of soluble repetitive domain elucidates the initial
      beta-sheet formation of spider silk.
AB  - The beta-sheet is the key structure underlying the excellent mechanical
      properties of spider silk. However, the comprehensive mechanism underlying beta
      sheet formation from soluble silk proteins during the transition into insoluble
      stable fibers has not been elucidated. Notably, the assembly of repetitive
      domains that dominate the length of the protein chains and structural features
      within the spun fibers has not been clarified. Here we determine the conformation
      and dynamics of the soluble precursor of the repetitive domain of spider silk
      using solution-state NMR, far-UV circular dichroism and vibrational circular
      dichroism. The soluble repetitive domain contains two major populations: ~65%
      random coil and ~24% polyproline type II helix (PPII helix). The PPII helix
      conformation in the glycine-rich region is proposed as a soluble prefibrillar
      region that subsequently undergoes intramolecular interactions. These findings
      unravel the mechanism underlying the initial step of beta-sheet formation, which
      is an extremely rapid process during spider silk assembly.

PMID- 29844576
TI  - Local field potential decoding of the onset and intensity of acute pain in rats.
AB  - Pain is a complex sensory and affective experience. The current definition for
      pain relies on verbal reports in clinical settings and behavioral assays in
      animal models. These definitions can be subjective and do not take into
      consideration signals in the neural system. Local field potentials (LFPs)
      represent summed electrical currents from multiple neurons in a defined brain
      area. Although single neuronal spike activity has been shown to modulate the
      acute pain, it is not yet clear how ensemble activities in the form of LFPs can
      be used to decode the precise timing and intensity of pain. The anterior
      cingulate cortex (ACC) is known to play a role in the affective-aversive
      component of pain in human and animal studies. Few studies, however, have
      examined how neural activities in the ACC can be used to interpret or predict
      acute noxious inputs. Here, we recorded in vivo extracellular activity in the ACC
      from freely behaving rats after stimulus with non-noxious, low-intensity noxious,
      and high-intensity noxious stimuli, both in the absence and chronic pain. Using a
      supervised machine learning classifier with selected LFP features, we predicted
      the intensity and the onset of acute nociceptive signals with high degree of
      precision. These results suggest the potential to use LFPs to decode acute pain.

PMID- 29844577
TI  - IMMP2L: a mitochondrial protease suppressing cellular senescence.

PMID- 29844579
TI  - Dimethyl fumarate: targeting glycolysis to treat MS.

PMID- 29844578
TI  - Destabilization of linker histone H1.2 is essential for ATM activation and DNA
      damage repair.
AB  - Linker histone H1 is a master regulator of higher order chromatin structure, but
      its involvement in the DNA damage response and repair is unclear. Here, we report
      that linker histone H1.2 is an essential regulator of ataxia telangiectasia
      mutated (ATM) activation. We show that H1.2 protects chromatin from aberrant ATM
      activation through direct interaction with the ATM HEAT repeat domain and
      inhibition of MRE11-RAD50-NBS1 (MRN) complex-dependent ATM recruitment. Upon DNA
      damage, H1.2 undergoes rapid PARP1-dependent chromatin dissociation through poly
      ADP-ribosylation (PARylation) of its C terminus and further proteasomal
      degradation. Inhibition of H1.2 displacement by PARP1 depletion or an H1.2
      PARylation-dead mutation compromises ATM activation and DNA damage repair, thus
      leading to impaired cell survival. Taken together, our findings suggest that
      linker histone H1.2 functions as a physiological barrier for ATM to target the
      chromatin, and PARylation-mediated active H1.2 turnover is required for robust
      ATM activation and DNA damage repair.

PMID- 29844580
TI  - Aberrant erythropoiesis fuels tumor growth.

PMID- 29844581
TI  - Deadlier than the malate.

PMID- 29844582
TI  - Plant G-protein activation: connecting to plant receptor kinases.

PMID- 29844583
TI  - Tissue clearing of both hard and soft tissue organs with the PEGASOS method.
AB  - Tissue clearing technique enables visualization of opaque organs and tissues in 3
      dimensions (3-D) by turning tissue transparent. Current tissue clearing methods
      are restricted by limited types of tissues that can be cleared with each
      individual protocol, which inevitably led to the presence of blind-spots within
      whole body or body parts imaging. Hard tissues including bones and teeth are
      still the most difficult organs to be cleared. In addition, loss of endogenous
      fluorescence remains a major concern for solvent-based clearing methods. Here, we
      developed a polyethylene glycol (PEG)-associated solvent system (PEGASOS), which
      rendered nearly all types of tissues transparent and preserved endogenous
      fluorescence. Bones and teeth could be turned nearly invisible after clearing.
      The PEGASOS method turned the whole adult mouse body transparent and we were able
      to image an adult mouse head composed of bones, teeth, brain, muscles, and other
      tissues with no blind areas. Hard tissue transparency enabled us to reconstruct
      intact mandible, teeth, femur, or knee joint in 3-D. In addition, we managed to
      image intact mouse brain at sub-cellular resolution and to trace individual
      neurons and axons over a long distance. We also visualized dorsal root ganglions
      directly through vertebrae. Finally, we revealed the distribution pattern of
      neural network in 3-D within the marrow space of long bone. These results suggest
      that the PEGASOS method is a useful tool for general biomedical research.

PMID- 29844584
TI  - Dynamics of directional tuning and reference frames in humans: A high-density EEG
      study.
AB  - Recent developments in EEG recording and signal processing have made it possible
      to record in an unconstrained, natural movement task, therefore EEG provides a
      promising approach to understanding the neural mechanisms of upper-limb reaching
      control. This study specifically addressed how EEG dynamics in the time domain
      encoded finger movement directions (directional tuning) and posture dependence
      (movement reference frames) by applying representational similarity analysis.
      High-density EEG covering the entire scalp was recorded while participants
      performed eight-directional, center-out reaching movements, thereby allowing us
      to explore directional selectivity of EEG sources over the brain beyond
      somatosensory areas. A majority of the source processes exhibited statistically
      significant directional tuning during peri-movement periods. In addition,
      directional tuning curves shifted systematically when the shoulder angle was
      rotated to perform the task within a more laterally positioned workspace, the
      degree of tuning curve rotation falling between that predicted by models assuming
      extrinsic and shoulder-based reference frames. We conclude that temporal dynamics
      of neural mechanisms for motor control can be studied noninvasively in humans
      using high-density EEG and that directional sensitivity of motor and non-motor
      processing is not limited within the sensorimotor areas but extends to the whole
      brain areas.

PMID- 29844585
TI  - Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal
      cancer.
AB  - Overweight and obesity are associated with increased risk of developing metabolic
      disorders such as diabetes and cardiovascular diseases. However, besides these
      metabolic diseases, excess body weight is also associated with different cancers,
      including gastrointestinal cancers, such as liver, pancreatic and colon cancers.
      Inflammation is a common feature of both obesity and cancer; however, the origin
      of this inflammation has been largely debated. Over the past decade, growing
      evidence has shown that the composition of the gut microbiota and its activity
      might be associated not only with the onset of inflammation but also with
      metabolic disorders and cancer. Here, we review the links between the gut
      microbiota, gut barrier function and the onset of low-grade inflammation in the
      development of gastrointestinal cancer. We also describe the mechanisms by which
      specific microorganism-associated molecular patterns crosstalk with the immune
      system and how the metabolic activity of bacteria induces specific signalling
      pathways beyond the gut that eventually trigger carcinogenesis.

PMID- 29844586
TI  - Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity.
AB  - Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal
      capillary channels of the liver and are the most abundant non-parenchymal hepatic
      cell population. LSECs do not simply form a barrier within the hepatic sinusoids
      but have vital physiological and immunological functions, including filtration,
      endocytosis, antigen presentation and leukocyte recruitment. Reflecting these
      multifunctional properties, LSECs display unique structural and phenotypic
      features that differentiate them from the capillary endothelium present within
      other organs. It is now clear that LSECs have a critical role in maintaining
      immune homeostasis within the liver and in mediating the immune response during
      acute and chronic liver injury. In this Review, we outline how LSECs influence
      the immune microenvironment within the liver and discuss their contribution to
      immune-mediated liver diseases and the complications of fibrosis and
      carcinogenesis.

PMID- 29844587
TI  - Mitochondrial function - gatekeeper of intestinal epithelial cell homeostasis.
AB  - The intestinal epithelium is a multicellular interface in close proximity to a
      dense microbial milieu that is completely renewed every 3-5 days. Pluripotent
      stem cells reside at the crypt, giving rise to transient amplifying cells that go
      through continuous steps of proliferation, differentiation and finally anoikis (a
      form of programmed cell death) while migrating upwards to the villus tip. During
      these cellular transitions, intestinal epithelial cells (IECs) possess distinct
      metabolic identities reflected by changes in mitochondrial activity.
      Mitochondrial function emerges as a key player in cell fate decisions and in
      coordinating cellular metabolism, immunity, stress responses and apoptosis.
      Mediators of mitochondrial signalling include molecules such as ATP and reactive
      oxygen species and interrelate with pathways such as the mitochondrial unfolded
      protein response (MT-UPR) and AMP kinase signalling, in turn affecting cell cycle
      progression and stemness. Alterations in mitochondrial function and MT-UPR
      activation are integral aspects of pathologies, including IBD and cancer.
      Mitochondrial signalling and concomitant changes in metabolism contribute to
      intestinal homeostasis and regulate IEC dedifferentiation-differentiation
      programmes in the context of diseases, suggesting that mitochondrial function as
      a cellular checkpoint critically contributes to disease outcome. This Review
      highlights mitochondrial function and MT-UPR signalling in epithelial cell
      stemness, differentiation and lineage commitment and illustrates mitochondrial
      function in intestinal diseases.

PMID- 29844588
TI  - Noninvasive biomarkers in NAFLD and NASH - current progress and future promise.
AB  - Nonalcoholic fatty liver disease (NAFLD) affects 25% of the global adult
      population and is the most common chronic liver disease worldwide. Nonalcoholic
      steatohepatitis (NASH) is the active form of NAFLD, with hepatic
      necroinflammation and faster fibrosis progression. With an increasing number of
      patients developing NASH-related end-stage liver disease and pharmacological
      treatments on the horizon, there is a pressing need to develop NAFLD and NASH
      biomarkers for prognostication, selection of patients for treatment and
      monitoring. This requirement is particularly true as liver biopsy utility is
      limited by its invasive nature, poor patient acceptability and sampling
      variability. This article reviews current and potential biomarkers for different
      features of NAFLD, namely, steatosis, necroinflammation and fibrosis. For each
      biomarker, we evaluate its accuracy, reproducibility, responsiveness, feasibility
      and limitations. We cover biochemical, imaging and genetic biomarkers and discuss
      biomarker discovery in the omics era.

PMID- 29844589
TI  - Correction to: TAOK1 negatively regulates IL-17-mediated signaling and
      inflammation.
AB  - In this article, published online 5 February 2018, the second primer of mouse
      actin, il-6, il-1beta, TNFalpha, cxcl1, cxcl2, and ccl20 in Table 2 should be
      marked as "reverse primer" instead of "forward primer". Corrected Table 2 is
      shown below. The authors regret the errors.

PMID- 29844590
TI  - Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the
      immunosuppression of B cells.
AB  - Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is
      crucial for the suppressive functions of Bregs. However, little is known
      regarding how IL-10 production is regulated in B cells. To explore the mechanisms
      by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for
      molecules that are upregulated in IL-10-producing B cells and identified RNA
      binding motif protein 47 (Rbm47) as a post-transcriptional regulator. Rbm47 was
      found to promote IL-10 production in B cells. We found that Rbm47 promotes the
      stability of IL-10 mRNA by binding to AU-rich elements in the 3' untranslated
      region of Il10 mRNA. In addition, we demonstrated that the overexpression of
      Rbm47 enabled B cells to facilitate Foxp3+ regulator T-cell induction and reduce
      the severity of DSS-induced ulcerative colitis. Taken together, these results
      suggest that Rbm47 plays an important role in regulating IL-10 at the post
      transcriptional level, thus promoting the regulatory functions of B cells. The
      findings presented in this study not only increase our understanding of the post
      translational regulation of IL-10 in B cells but also identify a novel strategy
      for the potential application of Bregs.

PMID- 29844591
TI  - Cystathionine-gamma-lyase ameliorates the histone demethylase JMJD3-mediated
      autoimmune response in rheumatoid arthritis.
AB  - Cystathionine-gamma-lyase (CSE), an enzyme associated with hydrogen sulfide (H2S)
      production, is an important endogenous regulator of inflammation. Jumonji domain
      containing protein 3 (JMJD3) is implicated in the immune response and
      inflammation. Here, we investigated the potential contribution of JMJD3 to
      endogenous CSE-mediated inflammation in rheumatoid arthritis (RA). Upregulated
      CSE and JMJD3 were identified in synovial fibroblasts (SFs) from RA patients as
      well as in the joints of arthritic mice. Knocking down CSE augmented inflammation
      in IL-1beta-induced SFs by increasing JMJD3 expression. In addition, CSE-/- mice
      with collagen-induced arthritis (CIA) developed severe joint inflammation and
      bone erosion. Conversely, overexpressing CSE inhibited JMJD3 expression by the
      transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1beta
      treated SFs. Furthermore, JMJD3 silencing or the administration of the JMJD3
      inhibitor GSK-J4 significantly decreased the inflammatory response in IL-1beta
      treated SFs, mainly by controlling the methylation status of H3K27me3 at the
      promoter of its target genes. GSK-J4 markedly attenuated the severity of
      arthritis in CIA mice. In conclusion, suppressing JMJD3 expression by the
      transcription factor Sp-1 is likely responsible for the ability of CSE to
      negatively modulate the inflammatory response and reduce the progression of RA.

PMID- 29844592
TI  - Image-based modeling of gas adsorption and deformation in porous media.
AB  - Understanding adsorption of CO2 in porous formations is crucial to its
      sequestration in geological formations. We describe a model for adsorption of CO2
      and the deformation that it induces in a sandstone formation over wide ranges of
      temperature and pressure. The model couples the thermodynamics of sorption with
      elastic deformation of the solid. Finite-element computations are then used in
      order to compute CO2 adsorption isotherms along with the induced strain in the
      formation. We also compute the Darcy permeability of the porous medium using the
      lattice-Boltzmann method. All the computations are carried out with a three
      dimensional image of a core sample from Mt. Simon sandstone, the target porous
      formation for a pilot CO2 sequestration project that is currently being carried
      out by Illinois State Geological Survey. Thus, no assumptions are made regarding
      the shape and sizes of the pore throats and pore bodies. The computed CO2
      sorption isotherm at 195 K is in excellent agreement with our experimental data.
      The computed permeability is also in good agreement with the measurement. As a
      further test we also compute the sorption isotherm of N2 in the same formation at
      77.3 K, and show that it is also in good agreement with our experimental data.
      The model is capable of predicting adsorption of CO2 (or any other gas for that
      matter) in porous formations at high pressures and temperatures. Thus, it is used
      to study the effect of hydrostatic pressure on adsorption and deformation of the
      porous formation under various conditions. We find that the effect of the
      confining pressure is more prominent at higher temperatures. Also computed is the
      depth-dependence of the capacity of the formation for CO2 adsorption, along with
      the induced volumetric strain.

PMID- 29844593
TI  - FDA approves first-in-class SYK inhibitor.

PMID- 29844594
TI  - Sepsis researchers set sights on immunotherapeutic strategies.

PMID- 29844595
TI  - BACE failures lower AD expectations, again.

PMID- 29844596
TI  - Cancer: Preventing metastatic relapse.

PMID- 29844597
TI  - Cancer: Personalized cancer vaccines hit the spot.

PMID- 29844598
TI  - When drugs unintentionally affect gut bugs.

PMID- 29844600
TI  - Cancer: Restoring p53 activity.

PMID- 29844599
TI  - On the origin of transformative drugs.

PMID- 29844601
TI  - Norbert Bischofberger.

PMID- 29844602
TI  - Liver disease: Reducing cancer risk.

PMID- 29844603
TI  - Autoimmune disease: Targeting glucose transport in psoriasis.

PMID- 29844604
TI  - HIV Reverse Transcriptase and Protease Genes Variability Can Be a Biomarker
      Associated with HIV and Hepatitis B or C Coinfection.
AB  - Variability of the HIV reverse transcriptase (RT) and protease (PR) genes has
      been used as indicators of drug resistance and as a mean to evaluate phylogenetic
      relationships among circulating virus. However, these studies have been carried
      in HIV mono-infected populations. The goal of this study was to evaluate, for the
      first time, the HIV PR and RT sequences from HIV/HBV and HIV/HCV co-infected
      patients. HIV PR and RT genes were amplificated and sequenced to resistance
      analysis. The bioinformatics analysis was performed to infer about sequences
      clustering and molecular evolution. The results showed that the most frequent
      amino acid substitutions in RT were L214F (67.6%), I135T (55.9%), and in PR was
      V15I (41.2%). The molecular clock analysis showed that the HIV circulating in co
      infected patients were separated in two clusters in the years 1999-2000. Some
      patients included as HIV mono-infected according patients' medical records and
      inside the co-infected cluster were, in fact, co-infected by PCR analysis.
      Analysis of the decision trees showed susceptibility to lamivudine and
      emtricitabine were important attribute to characterize co-infected patients. In
      conclusion, the results obtained in this study suggest, for the first time, that
      HIV RT and PR genes variability could be a genetic biomarker to coinfection.

PMID- 29844605
TI  - Temperature and the vertical movements of oceanic whitetip sharks, Carcharhinus
      longimanus.
AB  - Large-bodied pelagic ectotherms such as sharks need to maintain internal
      temperatures within a favourable range in order to maximise performance and be
      cost-efficient foragers. This implies that behavioural thermoregulation should be
      a key feature of the movements of these animals, although field evidence is
      limited. We used depth and temperature archives from pop-up satellite tags to
      investigate the role of temperature in driving vertical movements of 16 oceanic
      whitetip sharks, Carcharhinus longimanus, (OWTs). Spectral analysis, linear mixed
      modelling, segmented regression and multivariate techniques were used to examine
      the effect of mean sea surface temperature (SST) and mixed layer depth on
      vertical movements. OWTs continually oscillated throughout the upper 200 m of the
      water column. In summer when the water column was stratified with high SSTs,
      oscillations increased in amplitude and cycle length and sharks reduced the time
      spent in the upper 50 m. In winter when the water column was cooler and well
      mixed, oscillations decreased in amplitude and cycle length and sharks frequently
      occupied the upper 50 m. SSTs of 28 oC marked a distinct change in vertical
      movements and the onset of thermoregulation strategies. Our results have
      implications for the ecology of these animals in a warming ocean.

PMID- 29844606
TI  - What are bacteria doing in the bladder?

PMID- 29844607
TI  - High-field modulated ion-selective field-effect-transistor (FET) sensors with
      sensitivity higher than the ideal Nernst sensitivity.
AB  - Lead ion selective membrane (Pb-ISM) coated AlGaN/GaN high electron mobility
      transistors (HEMT) was used to demonstrate a whole new methodology for ion
      selective FET sensors, which can create ultra-high sensitivity (-36 mV/log
      [Pb2+]) surpassing the limit of ideal sensitivity (-29.58 mV/log [Pb2+]) in a
      typical Nernst equation for lead ion. The largely improved sensitivity has
      tremendously reduced the detection limit (10-10 M) for several orders of
      magnitude of lead ion concentration compared to typical ion-selective electrode
      (ISE) (10-7 M). The high sensitivity was obtained by creating a strong filed
      between the gate electrode and the HEMT channel. Systematical investigation was
      done by measuring different design of the sensor and gate bias, indicating ultra
      high sensitivity and ultra-low detection limit obtained only in sufficiently
      strong field. Theoretical study in the sensitivity consistently agrees with the
      experimental finding and predicts the maximum and minimum sensitivity. The
      detection limit of our sensor is comparable to that of Inductively-Coupled-Plasma
      Mass Spectrum (ICP-MS), which also has detection limit near 10-10 M.

PMID- 29844608
TI  - Reviewer Recognition 2017.

PMID- 29844609
TI  - Continuing Medical Education Questions: May 2018.

PMID- 29844611
TI  - Continuing Medical Education Questions: May 2018.

PMID- 29844612
TI  - In vivo wide-field calcium imaging of mouse thalamocortical synapses with an 8 K
      ultra-high-definition camera.
AB  - In vivo wide-field imaging of neural activity with a high spatio-temporal
      resolution is a challenge in modern neuroscience. Although two-photon imaging is
      very powerful, high-speed imaging of the activity of individual synapses is
      mostly limited to a field of approximately 200 um on a side. Wide-field one
      photon epifluorescence imaging can reveal neuronal activity over a field of >=1
      mm2 at a high speed, but is not able to resolve a single synapse. Here, to
      achieve a high spatio-temporal resolution, we combine an 8 K ultra-high
      definition camera with spinning-disk one-photon confocal microscopy. This
      combination allowed us to image a 1 mm2 field with a pixel resolution of 0.21 um
      at 60 fps. When we imaged motor cortical layer 1 in a behaving head-restrained
      mouse, calcium transients were detected in presynaptic boutons of thalamocortical
      axons sparsely labeled with GCaMP6s, although their density was lower than when
      two-photon imaging was used. The effects of out-of-focus fluorescence changes on
      calcium transients in individual boutons appeared minimal. Axonal boutons with
      highly correlated activity were detected over the 1 mm2 field, and were probably
      distributed on multiple axonal arbors originating from the same thalamic neuron.
      This new microscopy with an 8 K ultra-high-definition camera should serve to
      clarify the activity and plasticity of widely distributed cortical synapses.

PMID- 29844613
TI  - Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid
      Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid
      Transporter Mfsd2a.
AB  - Disruption of the blood-brain barrier (BBB) by cancer cells is linked to
      metastatic tumor initiation and progression; however, the pathways that drive
      these events remain poorly understood. Here, we have developed novel patient
      derived xenograft (PDX) models of brain metastases that recapitulate pathological
      growth features found in original patient samples, thus allowing for analysis of
      BBB disruption by tumor cells. We report that the BBB is selectively disrupted in
      brain metastases, in part, via inhibition of the endothelial cell-expressed
      docosahexaenoic acid (DHA) transporter, major facilitator superfamily domain 2a
      (Mfsd2a). Loss of Mfsd2a expression in the tumor endothelium results in enhanced
      BBB leakage, but reduced DHA transport and altered lipid metabolism within
      metastases. Mfsd2a expression in normal cerebral endothelial cells is
      cooperatively regulated by TGFbeta and bFGF signaling pathways, and these
      pathways are pathologically diminished in the brain metastasis endothelium. These
      results not only reveal a fundamental pathway underlying BBB disruption by
      metastatic cancer cells, but also suggest that restoring DHA metabolism in the
      brain tumor microenvironment may be a novel therapeutic strategy to block
      metastatic cell growth and survival.

PMID- 29844614
TI  - Cell behavior of the highly sticky bacterium Acinetobacter sp. Tol 5 during
      adhesion in laminar flows.
AB  - It is important to characterize how medically, industrially, or environmentally
      important bacteria adhere to surfaces in liquid flows in order to control their
      cell adhesion and subsequent biofilm formation. Acinetobacter sp. Tol 5 is a
      remarkably sticky bacterium that autoagglutinates through the adhesive nanofiber
      protein AtaA, which is applicable to cell immobilization in bioprocesses. In this
      study, the adhesion and behavior of Tol 5 cells in laminar flows were
      investigated using flow cell systems. Tol 5 cells autoagglutinated through AtaA
      and formed cell clumps during flowing. The cell clumps rather than single cells
      went downward due to gravity and adhered to the bottom surface. Under appropriate
      shear stress, a twin vortex was caused by a separated flow generated at the rear
      of the pre-immobilized cell clumps and carried the small cell clumps to this
      location, resulting in their stacking there. The rearward immobilized cell clumps
      developed into a large, stable aggregate with a streamlined shape, independent of
      cell growth. Cell clumps hardly ever developed under weak shear stress that could
      not generate a twin vortex and were broken up under excessively strong shear
      stress. These cell behaviors including the importance of clumping are interesting
      features in the bacterial adhesion processes.

PMID- 29844616
TI  - Building Integrated Photovoltaic Module-Based on Aluminum Substrate With Forced
      Water Cooling.
AB  - The increase of operating temperature on a photovoltaic (PV) cell degrades its
      electrical efficiency. This paper is organized to describe our latest design of
      an aluminum substrate-based photovoltaic/thermal (PV/T) system. The electrical
      efficiency of the proposed PV/T can be increased by ~ 20% in comparison with a
      conventional glass substrate-based PV. The work will benefit hybrid utilization
      of solar energy in development of building integrated photovoltaic systems.

PMID- 29844615
TI  - From genome-wide associations to candidate causal variants by statistical fine
      mapping.
AB  - Advancing from statistical associations of complex traits with genetic markers to
      understanding the functional genetic variants that influence traits is often a
      complex process. Fine-mapping can select and prioritize genetic variants for
      further study, yet the multitude of analytical strategies and study designs makes
      it challenging to choose an optimal approach. We review the strengths and
      weaknesses of different fine-mapping approaches, emphasizing the main factors
      that affect performance. Topics include interpreting results from genome-wide
      association studies (GWAS), the role of linkage disequilibrium, statistical fine
      mapping approaches, trans-ethnic studies, genomic annotation and data
      integration, and other analysis and design issues.

PMID- 29844617
TI  - Genistein: is the multifarious botanical a natural anthelmintic too?
AB  - Genistein (4',5,7-trihydroxyisoflavone) is naturally present in plants of the soy
      family and is known to have various pharmacological activities, such as anti
      cancer, anti-diabetic, anti-oxidant, etc. The phytoestrogen is one of the major
      isoflavones found in some medicinal plants having anthelmintic properties. This
      review describes the putative role of genistein as an anthelmintic, which has
      been tested on some helminth parasites in vitro. Genistein has been shown to
      cause paralysis and alterations in the tegument and tegumental enzymes (acid
      phosphatase, alkaline phosphatase, adenosine triphosphatase, and 5'-nucleotidase)
      of helminth parasites. Alterations in the activities of several enzymes
      associated with the coordination system (specifically non-specific esterases,
      acetylcholine esterase, and nitric oxide synthase), and changes in the
      concentration of nitric oxide, cGMP, free amino acid pool, and tissue ammonia are
      observed in helminth parasites treated with genistein. The phytoestrogen also
      affects the carbohydrate metabolism by altering the activities of key enzymes
      involved in glycogen- and glucose-metabolism of a cestode parasite. Considering
      the significance of phosphoenolpyruvate carboxykinase (PEPCK) in glycolysis of
      the cestode parasite, Ki of the phytoestrogen for PEPCK in the parasite has been
      determined, and molecular docking of genistein into the active site of the enzyme
      has also been described. The potential beneficial role of genistein as a natural
      alternative in management of helminth parasites needs to be further explored,
      particularly considering its in vivo efficacy and pharmacokinetics.

PMID- 29844618
TI  - Using proteomics as a powerful tool to develop a vaccine against Mediterranean
      visceral leishmaniasis.
AB  - Visceral leishmaniasis (VL) is a tropical infectious disease, which is called
      Mediterranean visceral leishmaniasis (MVL) in the Mediterranean area. In spite of
      many attempts, no effective commercial vaccine exists for MVL. To find new
      targets for developing antileishmanial vaccines, knowing parasite antigens that
      provoke the immune system are on demand. Nowadays, proteomics methods are defined
      as approaches for analysis of protein profiling of different cells. Within this
      framework, detection of new antigens is becoming more facilitated. In this
      review, we aimed to introduce possible targets using proteomics so; they could be
      used as candidates for developing vaccines against MVL. It can shed new light in
      the near future on the development of promising vaccines for MVL.

PMID- 29844619
TI  - Spatial distribution of Giardia lamblia infection among general population in
      Mazandaran Province, north of Iran.
AB  - Giardia lamblia is the most prevalent intestinal parasites of humans in Iran and
      other in the world although information on geographical distribution of
      giardiasis plays significant role in identifying communities at high risk, little
      attention has been paid to study human giardiasis using geographical information
      system. Therefore, the aim of the current study was to determine temporal and
      spatial patterns of human giardiasis distribution to identify possible high risk
      areas and seasons in northern Iran. A total of 4788 people referred to health
      centers in the Mazandaran Province of northern Iran were surveyed January to
      December 2015. From each person stool sample and questionnaire with socio
      demographic data were collected. Giardia infection was diagnosed using direct wet
      mount, formalin ether concentration and trichrome staining. The results were
      analyzed using Moran Local Indicators of spatial association and geographically
      weighted regression. The overall prevalence of Giardia infection was 4.6%
      (222/4788), and was significantly higher among those aged 5-9 years compared to
      their older peers (P < 0.0001). Our data showed a significant dependency between
      the prevalence of G. lamblia and age, job, residence, season and height from the
      sea (P < 0.0001). The results of this study provided a precise and specific
      spatial and temporal pattern of human giardiasis distribution in the Mazandaran
      Province, Iran. These evidences should be considered for proper control of
      disease decisions and strategies.

PMID- 29844620
TI  - Serological and molecular diagnosis of Toxoplasma gondii in patients with
      schizophrenia.
AB  - Schizophrenia is a persistent neuropsychiatric syndrome of uncertain source.
      Toxoplasmosis is the most prevalent parasitic protozoan infecting one-third of
      the worldwide human population. Infectious agents such as toxoplasma are the
      probable cause of schizophrenia. This study was aimed to evaluate the association
      between schizophrenia and toxoplasmosis using SAG1 and B1 Target gene. During
      February to December 2016, 92 patients with schizophrenia are imported in our
      study. All cases were assessed by serological (IgG and IgM antibodies) and
      molecular examinations. ELISA was performed by Commercial kits according to
      manufactures procedure. DNA was extracted and nested PCR was done using two pairs
      of primers. From 92 patients, 59 (64.13%) cases were positive for toxoplasmosis
      by serological examinations (14 samples positive for IgM and IgG, 40 samples
      positive for only IgG and 5 samples Positive for only IgM) and 58 (63.04%) were
      positive by Nested PCR technique. Based on the nested PCR method, 68.47 and
      47.82% of samples were positive by B1 and SAG1 genes, respectively. Our results
      showed the importance of use both serological and molecular diagnostic methods
      for accurate recognition of T. gondii in patients with schizophrenia. Moreover
      our results indicated that B1 gene is more sensitive than SAG1 gene.

PMID- 29844621
TI  - A new species of Camallanidae (Raillet and Henry, 1917) from a siluroid catfish
      in Barak River, Jiribam, Manipur (India).
AB  - Based on the two Camallanid gravid females recovered from the intestine of
      siluroid catfish Aorichthys aor (Hamilton, 1822) in Barak River, Jiribam,
      Manipur, India, Procamallanus (Spirocamallanus) jiriensis n. sp. is described. It
      is morphologically characterized by 20-24 (9-incomplete) spiral thickenings
      (ridges), occupying posterior 2/3rd of the buccal capsule. The present species
      differs from its closely related species Procamallanus (Spirocamallanus) chauhani
      (Sahay in Indian J Helminthol 18(2):114-122, 1966) in many aspects such as two
      pair of teeth antero laterally present in oral cavity, a pair of finger-shaped
      thickenings, which is laterally present at the buccal capsule, presence of well
      developed globular vulvar lips, vagina directed posteriorly from vulva, a small
      conical spike-like projection at the rounded tail tip with well-developed caudal
      muscles and papillae.

PMID- 29844622
TI  - Achievement amastigotes of Leishmania infantum and investigation of pathological
      changes in the tissues of infected golden hamsters.
AB  - Leishmania infantum is an agent of visceral leishmaniasis (VL). Amastigote form
      is a more appropriate target for investigations on vaccines, treatment, and
      diagnosis. This study aimed to achieve the amastigotes of L. infantum in the
      golden hamster and J774 macrophages and report the pathological changes that
      occur in the liver and spleen of the hamsters with VL. 4 male golden hamsters
      were infected with L. infantum promastigotes. After 5 months, the hamsters were
      euthanized and touch and pathology smears were prepared from the livers and
      spleens. Then, these tissues were homogenized and centrifuged at 100*g.
      Supernatants were collected and centrifuged at 2000*g and the pellets were
      collected. In the next part of our study, J774 macrophages were infected with L.
      infantum promastigotes. Then, the infected macrophages were ruptured. Centrifuge
      stages were done same the previous part. The amastigotes were observed in touch
      and pathology smears. A load of amastigotes in the livers was more than the
      spleens in both types of smears. Although the livers' structure had undergone
      pathological changes, the spleens were unchanged. Also, the macrophage
      infectivity ratio was up to 95%. Our results present a simple and accessible way
      of achieving a lot of pure and real amastigotes for different fields in
      Leishmania. Also, it seems that the pathological changes occurring in the spleen
      and the liver of animals with VL are different and probably can be attributed to
      the genetic and immune process of the infected animals.

PMID- 29844623
TI  - Efficacy of some essential oils on Cephalopina titillator with special concern to
      nasal myiasis prevalence among camels and its consequent histopathological
      changes.
AB  - Nasopharyngeal myiasis is an important high incidence disease among camels in the
      Middle East and North of Africa caused by Cephalopina titillator (C. titillator)
      that results in sever economic losses in many camel breeding areas around the
      world. The current study was conducted to evaluate the efficacy of three
      essential oils; camphor, ginger and cinnamon oils and their histopathological
      effects on the 3rd larval instar of C. titillator, with special regard to the
      prevalence percentage of C. titillator infestation in slaughtered camels at
      Egyptian abattoirs in addition to investigate histopathological alterations of
      the infested animal's tissue. This study fulfilled that the prevalence of C.
      titillator infestation was 35.2% among slaughtered camels during summer season.
      The three tested essential oils were caused a significant mortality of C.
      tittilator; however, camphor oil was exhibited greater and quicker insecticidal
      effect than ginger and cinnamon oils at the same concentration in terms of
      mortality of the 3rd instar C. tittilator larvae. There was a concentration
      dependent effect on the larvae among the tested essential oils. The tested
      essential oils were caused remarkable histopathological alterations on the
      treated larval cuticle. The main salient lesions of the examined infested camel's
      tissue were necrotic and inflammatory alterations associated with cystic dilation
      of submucosal glands.

PMID- 29844624
TI  - Effect of entomopathogenic nematode of Heterorhabditis indica infection on immune
      and antioxidant system in lepidopteran pest Spodoptera litura (Lepidoptera:
      Noctuidae).
AB  - Entomopathogenic nematodes form excellent tools to study insect immunity in
      response to during infection. Insects activate as several defense mechanisms,
      namely Phenoloxidase, haemocytes, detoxification and antioxidant enzymes. However
      little mechanistic information is available about the sublethal effects of
      entomopathogenic nematodes infection on detoxification and immune mechanisms in
      lepidopteran insects. In the present study, the effects of infection on
      antioxidant, detoxification and immune systems of Spodoptera litura larvae were
      studied. Results show a significant reduction in Total Haemocyte Count observed
      after 3 h of infection. A significant increase Superoxide dismutase, Catalase,
      Glutathione S-transferase, Glutathione Peroxidase and Acid phosphatase were
      observed 6 h after infection and, progressive decrease in Peroxidase, Alkaline
      phosphatase and Lipid peroxidation was also observed. This study shows that
      increased detoxification enzyme levels in response to nematode infection are a
      protective mechanism in insects. Nematode infection suppresses insect immune
      response, which is evident from low haemocyte count and Phenoloxidase levels to
      ultimately cause larval mortality.

PMID- 29844625
TI  - Biochemical and ultrastructural changes in Raillietina echinobothrida in vitro
      exposed to extract of Lysimachia ramosa.
AB  - Lysimachia ramosa (Primulaceae) is a traditionally used medicinal plant, leaves
      extract of which is being widely used by the Jaintia tribes of Meghalaya, India
      for controlling helminthiasis. Preliminary investigation carried out on helminth
      parasites revealed that the crude extract of the plant causes deformity in the
      surface topography leading to death of the parasites. Therefore, the present
      study was conducted to identify the specific fraction of the crude leaf extract
      of the plant responsible for cestocidal efficacy, through biochemical and
      ultrastructural studies in Raillietina echinobothrida exposed to crude extract
      and its different fractions namely hexane, chloroform, ethyl acetate and n
      butanol. A dose dependent efficacy, with highest rate of mortality among n
      butanol exposed parasites was recorded. The treated parasites exhibited complete
      erosion of microtriches from the tegument, disintegration of muscle bundles,
      cellular organelles, plasma membrane, nuclear membrane, nucleolus and
      vacuolization of mitochondria was also observed. Observations on histochemical
      distribution of some important tegumental enzymes like adenosine triphosphatase
      (ATPase), alkaline phosphatase (AlkPase), acid phosphatase (AcPase) and
      5'Nucleotidase (5'-Nu) revealed a marked diminished stain intensity in the
      tegument of R. echinobothrida exposed to the crude extract and n-butanol fraction
      of the crude extract compared to the control. Highest reduction (77.93%) in the
      activity of ATPase was observed when the parasites exposed to 6 mg n-butanol
      fraction/ml of PBS. The results suggest that these enzymes act as target for
      anthelmintic stress caused by the phytochemicals present in the plant.

PMID- 29844626
TI  - Furcocercous cercariae infecting freshwater snails in Malabar: two new species
      from Lymnea luteola Lamarck and Gyraulus convexiusculus (Hutton).
AB  - The present paper describes two new species of furcocercous cercariae, Cercaria
      sp. XVIII Malabar n. sp. and Cercaria sp. XIX Malabar n. sp. infecting the
      freshwater snails, Lymnea luteola and Gyraulus convexiusculus respectively in the
      Malabar region of Kerala. Cercaria sp. XVIII Malabar n. sp., is a distome,
      pharyngeate, non-ocellate, longifurcate furcocercous cercaria with two pairs of
      penetration glands and 16 pairs of flame cells and recovered from L. luteola.
      Cercaria sp. XIX Malabar n. sp., is also a distome, pharyngeate, longifurcate
      cercaria with a pair of unpigmented eyespots and 20 pairs of flame cells and
      recovered from G. convexiusculus. Sporocysts of both the cercariae developed in
      the digestive glands. The present paper describes the cercariae and compares them
      with related species to establish their systematic position.

PMID- 29844627
TI  - Description of Tetracotyle wayanadensis n. sp. (Digenea: Strigeidae) metacercaria
      infecting six species of freshwater fishes from Western Ghats, India.
AB  - Tetracotyle wayanadensis n. sp. (Digenea, Strigeidae) infecting different organs
      of six species of freshwater fishes, Haludaria fasciata (eye, buccal cavity),
      Amblypharyngodon melettinus (eye, buccal cavity), Aplochelus lineatus (operculum,
      heart, mesenteries), Pethia conchonius (brain), Parambassis thomassi (muscles,
      mesenteries) and Lepidocephalus thermali (mesenteries) collected from water
      bodies in the Wayanad region of the Western Ghats is described and illustrated.
      Tetracotyle wayanadensis n. sp. is new to the genus and is separated from its
      congeners on the basis of differences in morphology and morphometry. The present
      paper also describes the prevalence, intensity, mean abundance and sites of
      infection of the parasite in each host. The prevalence of infection of T.
      wayanadensis n. sp. in Haludaria fasciata is 7.5%, intensity of infection is 2.66
      and mean abundance is 0.2; in Amblypharyngodon melettinus 10%, 6 and 0.6; in
      Aplochelus lineatus 12.2%, 6.2 and 0.76; in Pethia conchonius 7.14%, 5 and 0.36;
      in Parambassis thomassi 100%, 2 and 2; in Lepidocephalus thermali 10%, 2 and 0.2
      respectively.

PMID- 29844628
TI  - The impact of anthelminthic therapeutics on serological and tissues apoptotic
      changes induced by experimental trichinosis.
AB  - Trichinosis is a sharable parasitic disease caused by Trichinella spp., the
      disease occurred on eating inappropriate cooked pork infected by the parasite
      encysted larvae. This study aimed to evaluate experimentally the impact of
      treatment by thiabendazole, praziquantel (PZQ) and prednisone on T. spiralis
      induced parasitological, serological and apoptotic changes. Forty albino rats
      were infected orally each by +/- 1000 larvae, divided into four groups each of 10
      rats, group (A) infected control, group (B) thiabendazole tested, group (C) PZQ
      tested and group (D) prednisone tested. On the seventh and 40th days post
      infection, all groups were evaluated parasitologically by the number of the
      intestinal worms and the muscular encysted larvae, while IFN-gamma and TNF-alpha
      were estimated by ELISA, histopathological and histochemical assessment of the
      tissue changes during both phases were performed by different stains. In
      conclusion, thiabendazole was a potent and curable drug, it showed nearly 100%
      efficacy on intestinal worms, highly significant variations in cytokines levels
      during both the intestinal and muscular phases, while it induced moderate effects
      on encysted muscular larvae number, In addition it ameliorated myocytes apoptotic
      changes induced by trichinosis.

PMID- 29844629
TI  - Some epidemiological aspects of cutaneous leishmaniasis with emphasis on vectors
      and reservoirs of disease in the borderline of Iran and Iraq.
AB  - Cutaneous leishmaniasis (CL) is endemic and a major health problem in 17
      provinces out of 31 in Iran. This study aimed to determine vectors and reservoirs
      of the disease using molecular techniques in the borderline of Iran and Iraq.
      Sand flies and rodents were sampled using sticky paper traps and metal wire live
      traps, respectively, in the selected villages. About 10% of archived confirmed
      human positive slides was randomly checked for Leishmania by PCR-RFLP assay. The
      female sand flies were dissected in alcohol 96% in a sterile condition, the head
      and two segments of the abdomen end permanently mounted for identification and
      the remaining of body used for DNA extraction. The direct parasitological tests
      were carried out on the stained slides of rodents for Leishmania as well as PCR
      RFLP assay used for molecular detection of parasite. A total of 2050 sand flies
      were identified comprising of Phlebotomus papatasi, Sergentomyia sintoni, Se.
      clydei, Se. mervynae, Se. theodori, Se. dentate and Se. iranica. The Ph. papatasi
      was ranked as a prevailing sand fly species. Molecular tests on female sand flies
      revealed infection of Ph. papatasi to Leishmania major. Direct parasitology and
      molecular tests confirmed of 20% infection to L. major among the sole rodents
      species "Tatera indica". Due to wide dispersion of rodents colonies in the area
      and long favorite climate condition for sand flies, the CL foci will be provided
      the health risk for the religious tourists.

PMID- 29844630
TI  - Sandflies species composition, activity, and natural infection with Leishmania,
      parasite identity in lesion isolates of cutaneous leishmaniasis, central Iran.
AB  - Zoonotic cutaneous leishmaniosis (ZCL) is a crucial public health challenge in
      Iran. Sandflies feed on reservoir rodents' blood infected with Leishmania
      parasite and transmit it to other hosts. This study was conducted to find out the
      composition and monthly activity of sandflies as well as to identify the
      protozoan pathogens (Leishmania/Crithidia) by polymerase chain reaction (PCR) in
      an emerging ZCL focus of Abarkooh, Yazd province, Iran, in 2016. A cross
      sectional study was done in rural areas of Abarkooh. From April to November 2016,
      sticky traps were used indoor and outdoor to capture sandflies once every
      fortnight. Their composition and monthly activity were recorded. Following
      identification of sandflies and DNA extraction from them, PCR was used to
      identify their parasite and match it against samples taken from ZCL confirmed and
      suspected patients' lesions. After collection, a total of 2045 sandflies (779
      indoor, 1266 outdoor) were identified to species level. Sandfly activity started
      early April in this area with two active peaks (one late May and the other late
      August) terminated about mid-November. Seven Phlebotomus species and three
      Sergentomyia species were identified. The most and the least abundant species
      were P. papatasi (40.1%) and P. alexandri (0.09%), respectively. Using PCR, only
      6% (12:200) of P. papatasi sandflies were infected with Leishmania parasite. No
      Crithidia was detected in either sandflies or human lesions (176 specimen). Based
      on the highest abundance both indoor and outdoor of P. papatasi, this sandfly was
      considered the main vector of ZCL in this area. The capture of P. caucasicus, P.
      mongolensis, and P. ansarii from rodent burrows showed these species were likely
      involved in pathogen transmission in reservoir rodents' burrows.

PMID- 29844631
TI  - Prevalence of cymothoid isopods (Crustacea, Isopoda) and proximate analysis of
      parasites and their host fishes, Southeastern India.
AB  - Cymothoid isopods (Crustacea, Isopoda) are considered as potential threat to the
      health of different fish species. In order to evaluate the prevalence and
      proximate analysis of Cymothoid isopods and its host, an investigation was
      carried out fish species belonging to families Hemiramphidae and Belonidae in the
      Palk Bay region, Southeastern India. A total of 1265 individuals of teleost fish
      belonging to family Hemiramphidae species, Hemiramphus far (462), H.
      archipelagicus (78), and H. lutkie (277) and another family Belonidae species,
      Tylosurus crocodilus (448), were examined for cymothoid ectoparasitic
      infestation. Prevalence in H. far was the highest (39%) for the cymothoid
      Mothocys plagulophora, while T. crocodilus was most infested (13%) with Mothocys
      renardi, H. far and H. lutkie were not infested by M. renardi while T. crocodilus
      was not infested by M. plagulophora. Proximate analysis showed reduced level of
      protein in parasite infested fish compared with non-infested individuals.
      However, carbohydrate and lipid concentrations were lower in infested fish than
      non-infested individuals. Proximate analysis values in the two parasites of
      Mothocys species were similar, and these values were comparable to those
      unaffected fish species indicating that parasites were well nourished. The
      proximate analysis of isopod parasite M. plagulophora showed 21.6 +/- 7.7, 1.26
      +/- 0.05, 5.49 +/- 1.06% of protein, carbohydrate and lipid respectively, and in
      M. renardi, 21.09 +/- 6.6, 1.32 +/- 0.12, 5.83 +/- 0.72% of protein, carbohydrate
      and lipid respectively. Cadmium levels were similar between affected and non
      affected fish individuals and among species. The Pb levels were comparable among
      all T. crocodilus individuals, but the levels of Cd not showed much variation
      between affected and unaffected individuals in all four fish species.

PMID- 29844632
TI  - Bioinformatics analysis of single and multi-hybrid epitopes of GRA-1, GRA-4, GRA
      6 and GRA-7 proteins to improve DNA vaccine design against Toxoplasma gondii.
AB  - Toxoplasma gondii, is a causative agent of morbidity and mortality in
      immunocompromised and congenitally-infected individuals. Attempts to construct
      DNA vaccines against T. gondii using surface proteins are increasing. The dense
      granule antigens are highly expressed in the acute and chronic phases of T.
      gondii infection and considered as suitable DNA vaccine candidates to control
      toxoplasmosis. In the present study, bioinformatics tools and online software
      were used to predict, analyze and compare the structural, physical and chemical
      characters and immunogenicity of the GRA-1, GRA-4, GRA-6 and GRA-7 proteins.
      Sequence alignment results indicated that the GRA-1, GRA-4, GRA-6 and GRA-7
      proteins had low similarity. The secondary structure prediction demonstrated that
      among the four proteins, GRA-1 and GRA-6 had similar secondary structure except
      for a little discrepancy. Hydrophilicity/hydrophobicity analysis showed multiple
      hydrophilic regions and some classical high hydrophilic domains for each protein
      sequence. Immunogenic epitope prediction results demonstrated that the GRA-1 and
      GRA-4 epitopes were stable and GRA-4 showed the highest degree of antigenicity.
      Although the GRA-7 epitope had the highest score of immunogenicity, this epitope
      was instable and had the lowest degree of antigenicity and half-time in
      eukaryotic cell. Also, the results indicated that GRA4-GRA7 epitope and GRA6-GRA7
      had the highest degree of antigenicity and immunogenicity among multi-hybrid
      epitopes, respectively. Totally, in the present study, single epitopes showed the
      highest degree of antigenicity compared with multi-hybrid epitopes. Given the
      results, it can be concluded that GRA-4 and GRA-7 can be powerful DNA vaccine
      candidates against T. gondii.

PMID- 29844633
TI  - Therapeutic potential effect of bone marrow-derived mesenchymal stem cells on
      chronic liver disease in murine Schistosomiasis Mansoni.
AB  - Some reports have shown that mesenchymal stem cells (MSCs) therapy could
      ameliorate chemically-induced hepatic fibrosis. This research assesses the
      therapeutic action of bone marrow mesenchymal stem cells (BM-MSCs) on chronic
      diseased liver in Schistosoma mansoni infected mice. All infected female mice
      divided into three groups, one group (15 mice) treated with oral praziquantel
      (PZQ), second group (15 mice) received intravenous injection of BM-MSCs and third
      group (15 mice) treated with both MSCs + PZQ. Two control groups (15 mice each)
      subdivided into one infected and second healthy one. BM-MSCs were obtained from
      bones of both femur and tibia of male mice (30 mice), then cultured and
      characterized morphologically by detection of CD105 by flow cytometer. Liver
      tissues for all groups were examined histopathologically. Measuring of the
      collagen 1 gene expression was done by real-time PCR and immunohistochemical
      study to detect stem cells differentiation for detection of MSCs engraftments in
      liver tissue. MSCs treatment caused marked improvement and regression of
      fibrosis, and prevents deposition of collagen and reduced the expression of
      collagen 1 gene in infected mice on their liver tissues, especially when used
      with PZQ in mice treatment. It can be concluded that, MSCs is a good therapeutic
      method for liver fibrosis caused by S. mansoni infection.

PMID- 29844634
TI  - Molecular detection of Hepatozoon canis in dogs from Kerala.
AB  - India has a wide range of agro-climatic zones which is highly conducive for a
      diverse range of vectors and canines are continuously exposed to the risk of
      spectrum of tick borne protozoan diseases. The brown dog tick, Rhipicephalus
      sanguineus is widely prevalent among dogs in Kerala and there is a high
      prevalence of this tick transmitted Babesia and Ehrlichia spp. infection.
      However, the incidence of Hepatozoon canis transmitted by the same tick species
      had not been reported in the state since 2004. Preliminary screening of client
      owned dogs revealed six dogs to be positive for typical gelatin capsule shaped
      gamonts of H. canis within neutrophils in blood smear by microscopic examination.
      A PCR assay was standardized to amplify a specific 737 bp fragment of 18S rRNA
      gene of H. canis. Phylogenetic analysis revealed closest relationship with West
      Indies isolate deposited at GenBank database. The present study records the
      molecular detection of this haemoparasite in the state, for the first time.

PMID- 29844635
TI  - Aphelenchoides manipurensis sp. nov. (Nematoda: Tylenchina) from Manipur, India.
AB  - Aphelenchoides manipurensis sp. nov. was collected from two different localities
      of Manipur. Though the specimens collected from two different areas show some
      variations in their morphology and morphometric data, it was taken as the same
      species due to similarities in many characters. A. manipurensis sp. nov. had
      females with L = 294.1-461.91 um, a = 24.28-38.14, b = 6.3-8.65, b' = 3.61-4.68,
      c = 12.47-16.46, c' = 3-4.25, stylet = 10.38-13.84 um, V = 68.88-71.69, post
      uterine sac = 25.98-53.63 um long and two lateral lines. Males were common with
      spicule of 10.38-17.3 um. Mucro were present in both sexes. Species presented
      with illustrations and morphometrics.

PMID- 29844636
TI  - Is the cattle tick Rhipicephalus annulatus Say, 1821 reared on the rabbit?
AB  - The cattle tick Rhipicephalus annulatus Say, 1821 (Acari: Ixodidae) is the main
      tick species on cattle in Egypt. This study was designed to know the possibility
      of rearing R. annulatus on rabbits in order to obtaining an adequate tick number
      and maintaining this tick species in lab to the next generation. Additionally, a
      comparison was performed between some biological parameters in R. annulatus fed
      on rabbits with that fed on cows. Six New Zealand white rabbits were used as a
      lab animal for rearing R. annulatus. The animals were divided into two groups.
      The first (G1) included four rabbits and the second (G2) included two rabbits. In
      G1, larvae fed until to reach unfed adults those were detached, cleaned their
      mouth parts carefully and re-fed on another rabbit. In G2, larvae were maintained
      on rabbits until to the fully fed females dropped. Oviposion, hatchability and
      life cycle of R. annulatus fed on rabbits were recorded and compared with those
      fed on cows. Results showed that although the cattle tick R. annulatus is highly
      specific to cattle, it is possible reared on rabbit in limited scale. The larvae
      well developed on the same rabbit to nymphs and adults. In G2, a very few adults
      completed their feeding and laid very small egg mass, some of eggs failed to
      hatch and a few recorded hatchability percentage not more than 9.1% in comparing
      98.3% in females fed on cow. In G1, the rearing technique led to slightly
      increase the egg mass and their hatchability that reached to 23.6% in comparing
      with the hatchability recorded in G2.

PMID- 29844637
TI  - Endoparasites of Crotalus tzabcan (Serpentes: Viperidae), with a checklist in
      rattlesnakes.
AB  - The helminth and pentastomid fauna of 50 specimens of Crotalus tzabcan from the
      Yucatan Peninsula, Mexico is documented. The examination revealed the presence of
      three nematode species (Hastospiculum onchocercum, Hexametra boddaertii, and
      Travassosascaris araujoi), and one pentastomid (Porocephalus crotali). The threee
      nematode species had the same prevalence (2%), while the pentastomid had a higher
      prevalence (8%). The pentastomid P. crotali was the most abundant and intense
      parasite, although it was only found in four snake hosts. Crotalus tzabcan acts
      as definitive host for the adult helminths and pentastomids, with rodents as the
      probable intermediate hosts. This work represents the first systematic survey on
      the parasitic helminth and pentastomid fauna of C. tzabcan, and includes four new
      geographical records. Additionally, a checklist of helminths and pentastomids
      reported for Crotalus and Sistrurus is provided. To date, a total of 32 helminth
      and 7 pentastomid species have been recorded as parasites of rattlesnakes.
      Nematoda possessed the highest species richness. The genera with the highest
      number of host species were Mesocestoides and Hexametra, followed by
      Kalicephalus. The rattlesnake species with the highest number of reported
      parasites was C. durissus (18 nematodes and 2 pentastomids).

PMID- 29844638
TI  - Gross, histopathology and molecular diagnosis of oesophagostomosis in sheep.
AB  - A total of 120 tissue samples (Rumen, reticulum, omasum, abomasum, small
      intestine and large intestine) were collected from slaughter houses in Chennai,
      Kanchipuram and Tiruvallur districts and five samples from necropsy room at
      Department of Veterinary Pathology, Madras Veterinary College, Chennai, Tamil
      Nadu. Overall prevalence of GI parasites was 52.00%. Among the positive samples,
      single infection was found to be more (53.84%) than themixed infection (46.15%).
      Out of which, oesophagostomosis was 17.00% and found as single infection. In
      oesophagostomosis, significant gross lesions observed in the small and large
      intestine were multiple small to large, round to irregular, hard, fibrotic,
      raised nodules. The wall of the large intestine was greatly thickened and
      oedematous and the nodules were seen projecting into the lumen and mucosal
      surface was intact. On histopathological examination, ileum of sheep showed
      parasitic nodules with central baso-eosinophilic necrotic area, larval stages in
      the necrotic area, surrounded by layers of inflammatory cells and finally
      encapsulated in a thick fibrous connective tissue capsule. Immunohistochemistry
      (IHC) with Vimentin showed intense cytoplasmic positive signals DAB Brown. PCR
      was carried out targeting ITS2 regions of the O. columbianum and O. venulosum.
      DNA isolated from both the faecal eggs and adult worms showed good amplification.

PMID- 29844639
TI  - Psoroptes mites infestation in a captive Burmese Red Serow (Capricornis
      sumatraensis subspecies rubidus) of Indo-Burma bio-diversity hotspot.
AB  - An 8 years old male Burmese Red Serow (Capricornis sumatraensis sub species
      rubidus) from Aizawl Zoological Park was presented to the Teaching Veterinary
      Clinical Complex. An exploratory skin scraping revealed existence of nymphal as
      well as adult stages of mites of the Psoroptes spp. which were not associated
      with any overt lesions typical to mite infestation such as pruritus, erythema or
      scaling of the epidermis. The mites were identified as per their morphology, size
      and shape. Haemato-biochemical analysis revealed alteration of certain
      haematological and biochemical parameters. The red blood corpuscles were found to
      have anucleate cells with mild to absent central pallor. The absolute counts
      showed neutrophilic leucocytosis with mild monocytosis and lymphocytosis.
      Eosinophilic count was towards the higher side, indicating that the infestation
      was mild. The serum calcium, albumin, triglyceride, urea nitrogen (BUN) were
      found to be lower than normal, whereas serum ALT, AST, LDH, ALP and serum amylase
      were higher than the established reference indices. Due to lack of haemato
      biochemical reference values specific to captive Serow, emphasis was given in
      this report to establish baseline data for this species.

PMID- 29844640
TI  - The first finding of Moniliformis moniliformis (Acanthocephala, Moniliformidae)
      in Belarus.
AB  - Information on the detection of acanthocephalan Moniliformis moniliformis
      (Bremser, 1811) in a striped field mouse in Belarus and the short description of
      this parasite is given. The first finding of this helminth in Belarus (Malorita
      district of Brest region, south-western part of Belarus) is reported. The
      functioning of the centre of moniliformosis on the drainage system in the
      Malorita district is described. Rodents, as well as other animals as definitive
      hosts and insects as intermediate hosts of acanthocephalan Moniliformis
      moniliformis, take part in centre formation. This helminth has a medical
      significance because parasitize not only animals but also humans.

PMID- 29844641
TI  - 2018 Expert Consensus on the Management of Adverse Effects of Antiplatelet
      Therapy for Acute Coronary Syndrome in Taiwan.
AB  - Antiplatelet therapy is a key component in the treatment of acute coronary
      syndrome (ACS). The management of ACS has evolved considerably over recent years
      with the development of new and more potent antiplatelet agents. Clinical trials
      on ACS have demonstrated that potent antiplatelet agents can more effectively
      reduce cardiovascular events. However, there is a tipping point between safety
      and efficacy, beyond which the risk of bleeding and other adverse effects can
      outweigh the benefits of antiplatelet therapy. Striking a balance between safety
      and efficacy remains a major challenge. A consensus meeting of an expert panel
      composed of Taiwanese experts was held to provide recommendations for the
      management of adverse effects in patients with ACS receiving antiplatelet
      therapy. The common adverse effects of antiplatelet therapy include upper
      gastrointestinal bleeding, ecchymosis, hematuria, epistaxis and ticagrelor
      related dyspnea. In this study, a literature review of these adverse events was
      performed and recommendations for the management were made.

PMID- 29844642
TI  - In-Hospital Implementation of Evidence-Based Medications is Associated with
      Improved Survival in Diabetic Patients with Acute Coronary Syndrome - Data from
      TSOC ACS-DM Registry.
AB  - Background: Patients with acute coronary syndrome (ACS) and diabetes mellitus
      (DM) receive less aggressive treatment and have worse outcomes in Taiwan. We
      sought to explore whether the current practices of prescribing guideline-directed
      medical therapy (GDMT) for ACS and clinical outcomes have improved over time.
      Methods: A total of 1534 consecutive diabetic patients with ACS were enrolled
      between 2013 and 2015 from 27 hospitals in the nationwide registry initiated by
      the Taiwan Society of Cardiology (the TSOC ACS-DM Registry). Baseline and
      clinical demographics, treatment, and clinical outcomes were compared to those of
      1000 ACS patients with DM recruited in the Taiwan ACS-full spectrum (ACS-FS)
      Registry, which was performed between 2008 and 2010. Results: Compared to the DM
      patients in the Taiwan ACS-FS Registry, even though reperfusion therapy was
      carried out in significantly fewer patients, the primary percutaneous coronary
      intervention (PCI) rate for ST-segment elevation myocardial infarction (STEMI)
      and the prescription rates of GDMT for ACS including P2Y12 inhibitors, renin
      angiotensin blockers, beta-blockers, and statins were significantly higher in
      those in the TSOC ACS-DM Registry. Moreover, significant reductions in 1-year
      mortality, recurrent nonfatal MI and stroke were observed compared to those of
      the DM patients in the Taiwan ACS-FS Registry. Multivariate analysis identified
      reperfusion therapy in combination with GDMT as a strong predictor of better 1
      year outcomes [hazard ratio (95% confidence interval) = 0.54 (0.33-0.89)].
      Conclusions: Marked improvements in performing primary PCI for STEMI and
      prescribing GDMT for ACS were observed over time in Taiwan. This was associated
      with improved 1-year event-free survival in the diabetic patients with ACS.

PMID- 29844643
TI  - Anti-Inflammatory Effect of Gallic Acid-Eluting Stent in a Porcine Coronary
      Restenosis Model.
AB  - Background: Gallic acid (3,4,5-trihydroxybenzoic acid) is a natural polyphenol
      and strong natural antioxidant found abundantly in red wine and green tea. The
      aim of this study was to examine the anti-inflammatory effect of a novel gallic
      acid-eluting stent in a porcine coronary restenosis model. Methods: Fifteen pigs
      were randomized into three groups; in which a total of 30 coronary arteries (10
      in each group) were implanted with gallic acid-eluting stents (GESs, n = 10),
      gallic acid and sirolimus-eluting stents (GSESs, n = 10), or sirolimus-eluting
      stents (SESs, n = 10). Histopathologic analysis was performed 28 days after
      stenting. Results: There were no significant differences in injury score and
      fibrin score among the groups, however there were significant differences in the
      internal elastic lamina (4.0 +/- 0.83 mm2 in GES vs. 3.0 +/- 0.53 mm2 in GSES vs.
      4.6 +/- 1.43 mm2 in SES, p < 0.0001), lumen area (2.3 +/- 0.49 mm2 in GES vs. 1.9
      +/- 0.67 mm2 in GSES vs. 2.9 +/- 0.56 mm2 in SES, p < 0.0001), neointimal area
      (1.7 +/- 0.63 mm2 in GES vs. 1.1 +/- 0.28 mm2 in GSES vs. 1.7 +/- 1.17 mm2 in
      SES, p < 0.05), and percent area of stenosis (42.4% +/- 9.22% in GES vs. 38.2% +/
      12.77% in GSES vs. 33.9% +/- 15.64% in SES, p < 0.05). The inflammation score
      was significantly lower in the GES and GSES groups compared to that in the SES
      group [1.0 (range: 1.0 to 2.0) in GES vs. 1.0 (range: 1.0 to 1.0) in GSES vs. 1.5
      (range: 1.0 to 3.0) in SES, p < 0.05]. Conclusions: The GES group had a greater
      percent area of stenosis than the SES group. Although gallic acid in the GES and
      GSES groups did not show a synergistic effect in suppressing neointimal
      hyperplasia, it resulted in greater inhibition of the inflammatory reaction in
      the porcine coronary restenosis model than in the SES group.

PMID- 29844644
TI  - Effect of Selective Thrombus Aspiration on Serum Lipoprotein-Associated
      Phospholipase A2 in Patients with ST-Elevation Myocardial Infarction Undergoing
      Primary Percutaneous Coronary Intervention with High Thrombus Burden.
AB  - Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a potential
      therapeutic target in acute coronary syndromes. Although recent evidence does not
      support the routine use of manual thrombus aspiration (TA) in patients with ST
      elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary
      intervention (PPCI), the use of TA is associated with a significant improvement
      in myocardial reperfusion, especially in patients with high thrombus burden
      (HTB). We hypothesized that TA would reduce the serum Lp-PLA2 levels in STEMI
      patients undergoing PPCI with HTB. Methods and results: Our study cohort included
      320 consecutive STEMI patients undergoing PPCI with HTB who were randomly
      assigned to receive either TA before PPCI (TA group, n = 160) or PPCI alone
      (standard PPCI group, n = 160). The baseline characteristics of study
      participants were well-matched. After 30 +/- 2 days, serum Lp-PLA2 levels
      decreased by 53.9% in the TA group (152.9 +/- 58.1 ng/mL) and decreased by 31.2%
      in the standard PPCI group (84.2 +/- 86.6 ng/mL, p < 0.001). The TA group had a
      significantly lower prevalence of balloon predilatation, number of stents used,
      total stent length and corrected thrombolysis in myocardial infarction frame
      count, and a higher percentage of myocardial blush grade >= 2 compared with the
      standard PPCI group (all p < 0.001). No significant difference between the groups
      was observed in 30 +/- 2 days for major adverse cardiovascular and
      cerebrovascular events (p = 0.702). Conclusions: After 30 +/- 2 days of
      treatment, TA may significantly reduce serum levels of Lp-PLA2 in STEMI patients
      undergoing PPCI with HTB.

PMID- 29844645
TI  - Deterioration of Deceleration Capacity of Heart Rate is Associated with Left
      Ventricular Hypertrophy in End-Stage Renal Disease Population.
AB  - Background: Left ventricular hypertrophy (LVH) is prevalent in patients with end
      stage renal disease (ESRD), and may be secondary to arterial stiffness and volume
      overload. It is unclear whether LVH is caused by autonomic nerve dysregulation
      (AND), a frequent condition in patients with ESRD that is characterized by
      sympathetic hyperactivity and vagal withdrawal. We hypothesized that AND
      estimated by heart rate variability (HRV) may be associated with LVH in patients
      with ESRD. Methods: We prospectively enrolled patients with ESRD undergoing
      hemodialysis. Cardiac function and LVH were assessed using echocardiography
      according to the recommendations of the American Society of Echocardiography.
      Holter recordings were used to quantify HRV and deceleration capacity (DC).
      Dataon comorbidities and medications, and serum markers were obtained. Logistic
      regression analysis was performed. Results: Among the 281 included patients, 63%
      had LVH. The patients with LVH were older, had more comorbidities and advanced
      diastolic dysfunction than those without LVH. The root mean square of successive
      differences (rMSSD) (9.10 +/- 5.44 versus 13.25 +/- 8.61; p = 0.004) and DC (2.08
      +/- 1.90 versus 3.89 +/- 1.45; p = 0.021) were lower in the patients with LVH
      than that in those without LVH. Multivariate regression analysis showed that
      hypertension, asymmetrical dimethylarginine (ADMA), advanced diastolic
      dysfunction grade, rMSSD, and DC were independently associated with LVH. Among
      these variables, DC and ADMA showed the highest diagnostic value for LVH with
      areas under curves of 0.701 and 0.751, respectively. Conclusions: AND is
      independently associated with LVH in patients with ESRD.

PMID- 29844646
TI  - Effect of Heart Rate-Oriented Therapy on Diastolic Functions in Patients with
      Heart Failure with Reduced Ejection Fraction.
AB  - Background: Resting heart rate (HR) is a strong predictor of cardiovascular
      mortality and morbidity in patients with heart failure with reduced ejection
      fraction (HFrEF). However, the effects of HR-lowering therapy on diastolic
      function in HFrEF patients are not well described. In this study, we aimed to
      investigate the effect of lowering HR on diastolic function in HFrEF patients
      with sinus rhythm. Methods: Fifty patients with HFrEF with coexisting diastolic
      dysfunction and sinus rhythm with resting HR > 70 bpm were prospectively included
      in the study. All patients were treated with intended HR-lowering therapy, which
      targeted a HR below 70 bpm. We divided the whole population according to the
      resting HR achieved with strict rate control (group 1) and to that achieved
      without strict rate control (group 2; HR > 70 bpm) at the end of the study. Left
      ventricular diastolic function and B-type natriuretic peptide (BNP) values at
      baseline and at the end of the study were compared in both groups. Results: No
      significant differences were found between the groups in terms of baseline
      parameters except for lower diastolic blood pressure in group 2. At the end of
      follow-up, E/Em ratio, E/A ratio and left atrial area significantly decreased
      with an increased deceleration time in group 1. The changes in HR (delta HR) were
      correlated with E/Em (r = 0.67, p < 0.001) and delta BNP level (r = 0.49, p <
      0.001). Conclusions: No significant differences were found between the groups in
      terms of baseline parameters except for lower diastolic blood pressure in group
      2. At the end of follow-up, E/Em ratio, E/A ratio and left atrial area
      significantly decreased with an increased deceleration time in group 1. The
      changes in HR (delta HR) were correlated with E/Em (r = 0.67, p < 0.001) and
      delta BNP level (r = 0.49, p < 0.001).

PMID- 29844647
TI  - The Relationship between Serum Apelin Levels and the Severity of Calcific Aortic
      Stenosis.
AB  - Background: Apelin, an endogenous peptide, has recently gained attention due to
      its positive inotropic effects in heart failure physiopathology. We investigated
      the relationship between serum apelin levels and the severity of calcific aortic
      stenosis (AS). Methods: A total of 68 consecutive patients diagnosed with
      calcific AS and a control group of 32 subjects were included in the study. The
      subjects were divided into three group as follows: the control group, the mild
      moderate AS group and the severe AS group. Blood samples were obtained from all
      of the subjects, which were used for biochemical comparisons of apelin 36 and
      high-sensitive C-reactive protein (hsCRP) levels. Results: Plasma apelin 36
      levels were significantly lower in the patients with severe AS [490 (247-1074)
      pg/ml] compared to both the mild-moderate AS [209 (97-453) pg/ml] and control
      [660 (378-1200) pg/ml] groups (p < 0.001). Correlation analysis between the left
      ventricular mass index and apelin concentrations revealed a significant negative
      correlation between the two parameters (p < 0.001, r = -0.478). Conclusions: Our
      study demonstrated decreased apelin levels and increased hsCRP concentrations in
      patients with severe calcific AS. Our findings may help to clarify the exact
      pathophysiologic role of apelin in cardiovascular diseases.

PMID- 29844648
TI  - Worldwide Prevalence of Brugada Syndrome: A Systematic Review and Meta-Analysis.
AB  - Background: Brugada syndrome (BrS) is considered to be an inherited arrhythmic
      disease associated with fatal complications and premature sudden unexpected
      death. The prevalence of the Brugada electrocardiogram pattern (BrP) has been
      reported in several countries. Nonetheless, the specific worldwide prevalence of
      BrS has not been reported. Objective: We estimated the worldwide prevalence of
      BrS and Type-2/3 BrP in general adult populations using a systematic review and
      meta-analysis of the existing literature. Methods: We thoroughly searched MEDLINE
      and SCOPUS databases up to March 2017. Included studies were population-based
      electrocardiogram studies in which prevalence was presented or could be
      calculated from available data. Pooled prevalence by country/region and/or
      ethnicity was estimated using a random-effect model. Results: Twenty-eight
      articles with atotal population of 369,068 were included in this study. The
      worldwide pooled prevalence of BrS was 0.5 per 1,000 [95% confidence interval
      (CI): 0.3-0.7]. The highest prevalence was reported in Southeast Asia (1.8 per
      1,000, 95% CI: 0.5-6.6); the lowest was found in North Africa (0 per 1,000). BrS
      in Asians was nine times more common than in Caucasians and 36 times more common
      than in Hispanics. The worldwide pooled prevalence of Type-2/3 BrP was 6.1 per
      1,000 (95% CI: 5.0-7.1). The highest prevalence was also reported in Southeast
      Asia (35.5 per 1,000, 95% CI: 17.1-53.9). Conclusions: This study revealed a
      significant difference in the worldwide prevalence of BrS and Type-2/3 BrP.
      Brugada electrocardiogram patterns are highly prevalent in Southeast Asia.

PMID- 29844649
TI  - Reappraisal of the Worldwide Prevalence of Brugada Syndrome and Brugada
      Phenotype: From the Old to the New Diagnostic Criteria.

PMID- 29844650
TI  - Epicardial Fat Thickness is Associated with Abnormal Left Ventricle Geometry in
      Newly Diagnosed Hypertension.
AB  - Background: Epicardial adipose tissue is an emerging cardio metabolic risk
      factor. Although an association between epicardial fat thickness (EFT) and left
      ventricle (LV) hypertrophy in hypertensive patients is known, the relationship
      between abnormal LV geometric patterns and EFT has yet to be investigated. The
      aim of the present study was to investigate the relationship between EFT and
      abnormal LV geometric patterns in hypertensive patients. Methods: Measurements
      were obtained from 343 patients with untreated essential hypertension (mean age
      51.6 +/- 5.5 years) and 52 healthy control subjects (mean age 51.8 +/- 4.5
      years). Four different geometric patterns (NG; normal geometry, CR; concentric
      remodeling, EH; eccentric hypertrophy, and CH; concentric hypertrophy) were
      determined according to LV mass index (LVMI) and relative wall thickness (RWt).
      EFT was measured using transthoracic echocardiography. High sensitive C-reactive
      protein (hs-CRP) and other biochemical markers were measured in all participants.
      Results: The highest EFT and hs-CRP values were determined in the CH group (EFT =
      8.9 +/- 2.1 mm) compared with the controls (EFT = 5.7 +/- 1.5 mm), followed by
      the NG (EFT = 5.9 +/- 1.6 mm), CR (EFT = 5.9 +/- 1.3 mm) and EH groups (EFT = 6.5
      +/- 1.6 mm) (all p < 0.05). In addition, the EFT values of the EH group were
      higher than the control, NG and CR groups (all p < 0.05). Multivariate linear
      regression analysis showed that EFT was independently associated with LV geometry
      (beta = 0.161, p = 0.032), total cholesterol level (beta = -0.129, p = 0.003),
      triglyceride level (beta = 0.266, p < 0.001), hs-CRP level (beta = 0.349, p <
      0.001), and creatinine level (beta = 0.108, p = 0.010). Conclusions: EFT is
      independently associated with abnormal LV geometry, LV hypertrophy, creatinine
      level, and low grade chronic inflammation.

PMID- 29844651
TI  - Idiopathic Isolated Right Ventricular Apical Hypertrophy.

PMID- 29844652
TI  - Heart Rate Behind Systemic Inflammatory Response Syndrome Associated with One
      Year Mortality in the Patients with Acute Myocardial Infarction?

PMID- 29844653
TI  - The Criteria of Systemic Inflammatory Response Syndrome Present Varying Impacts
      on One-Year Mortality in Patients with Acute Myocardial Infarction.

PMID- 29844654
TI  - Molecular Evolution and Functional Divergence of the IgLON Family.
AB  - IgLON family is a subgroup of cell adhesion molecules which is known to have
      diverse roles in neuronal development. IgLONs are characterized by possessing 3
      Ig-like C2 domains, which play a part in mediating various cellular interactions.
      Recently, IgLONs have been shown to be expressed at the blood-brain barrier
      (BBB). However, our understanding of the genetic divergence patterns and
      evolutionary rates of these proteins in relation to their functions, in general,
      and at the BBB, in particular, remains inadequate. In this study, 12 species were
      explored to shed more light on the phylogenetic origins, structure, functional
      specificity, and divergence of this family. A total of 40 IgLON genes were
      identified from vertebrates and invertebrates. The absence of IgLON family genes
      in Hydra vulgaris and Nematostella vectensis but not in Drosophila melanogaster
      suggests that this family appeared during the time of divergence of Arthropoda
      455 Mya. In general, IgLON genes have been subject to strong positive selection
      in vertebrates. Our study, based on IgLONs' structural similarity, suggests that
      they may play a role in the evolutionary changes in the brain anatomy towards
      complexity including regulating neural growth and BBB permeability. IgLONs'
      functions seem to be performed through complex interactions on the level of
      motifs as well as single residues. We identified several IgLON motifs that could
      be influencing cellular migration and proliferation as well as BBB integrity
      through interactions with SH3 or integrin. Our motif analysis also revealed that
      NEGR1 might be involved in MAPK pathway as a form of a signal transmitting
      receptor through its motif (KKVRVVVNF). We found several residues that were both
      positively selected and with highly functional specificity. We also located
      functional divergent residues that could act as drug targets to regulate BBB
      permeability. Furthermore, we identified several putative metalloproteinase
      cleavage sites that support the ectodomain shedding hypothesis of the IgLONs. In
      conclusion, our results present a bridge between IgLONs' molecular evolution and
      their functions.

PMID- 29844655
TI  - A Bayesian Gene-Based Genome-Wide Association Study Analysis of Osteosarcoma Trio
      Data Using a Hierarchically Structured Prior.
AB  - Osteosarcoma is considered to be the most common primary malignant bone cancer
      among children and young adults. Previous studies suggest growth spurts and
      height to be risk factors for osteosarcoma. However, studies on the genetic cause
      are still limited given the rare occurrence of the disease. In this study, we
      investigated in a family trio data set that is composed of 209 patients and their
      unaffected parents and conducted a genome-wide association study (GWAS) to
      identify genetic risk factors for osteosarcoma. We performed a Bayesian gene
      based GWAS based on the single-nucleotide polymorphism (SNP)-level summary
      statistics obtained from a likelihood ratio test of the trio data, which uses a
      hierarchically structured prior that incorporates the SNP-gene hierarchical
      structure. The Bayesian approach has higher power than SNP-level GWAS analysis
      due to the reduced number of tests and is robust by accounting for the
      correlations between SNPs so that it borrows information across SNPs within a
      gene. We identified 217 genes that achieved genome-wide significance. Ingenuity
      pathway analysis of the gene set indicated that osteosarcoma is potentially
      related to TP53, estrogen receptor signaling, xenobiotic metabolism signaling,
      and RANK signaling in osteoclasts.

PMID- 29844656
TI  - 360-degree suture trabeculotomy ab interno to treat open-angle glaucoma: 2-year
      outcomes.
AB  - Purpose: The purpose of this study was to evaluate the efficacy of 360-degree
      suture trabeculotomy (360S-LOT) ab interno for treating open-angle glaucoma
      (OAG). Risk factors of surgical failure were examined. Patients and methods: 360S
      LOT ab interno alone was performed for patients with uncontrolled OAG, and
      combined 360S-LOT ab interno/phacoemulsification was performed for patients with
      controlled OAG with a visually significant cataract between March 2014 and
      September 2015 at a single center. The patients were prospectively followed for 2
      years. The main outcome measures included 2-year intraocular pressure (IOP),
      number of anti-glaucoma medications used, postoperative complications, and
      predictive factors of surgical failure. Kaplan-Meier analysis was performed, with
      surgical success (with or without medication use) defined as postoperative IOP
      <=15 mmHg and IOP reduction >=20% (criterion A) or IOP <=12 mmHg and IOP
      reduction >=30% (criterion B). Predictive factors were evaluated using Cox
      proportional hazard ratios. Results: A total of 64 eyes of 64 patients were
      included, and 50 (78%) eyes of 64 eyes underwent a phacoemulsification
      combination procedure. Surgery significantly reduced IOP from 18.4 +/- 2.9 mmHg
      before surgery to 13.4 +/- 3.0 mmHg after surgery (P < 0.001). Patients used an
      average of 1.8 +/- 1.5 medications before surgery and 1.3 +/- 1.5 medications
      after surgery (P = 0.101). No serious postoperative complications were observed.
      The probability of surgical success was 49.2% and 16.0% using criteria A and B,
      respectively. No risk factors of surgical failure were identified. Conclusion:
      The 360S-LOT ab interno procedure is a favorable option for treating eyes with
      mild or moderate OAG.

PMID- 29844658
TI  - Evaluation of femtosecond laser in flap and cap creation in corneal refractive
      surgery for myopia: a 3-year follow-up.
AB  - Purpose: To evaluate femtosecond laser in flap and cap creation, detect some
      corneal biomechanical changes, and evaluate dry eye after laser in situ
      keratomileusis (LASIK), Femto-LASIK, and small incision lenticule extraction
      (SMILE) with 3-year follow-up. Patients and methods: Preoperative evaluation
      taken: full ophthalmic examination, Pentacam, ocular response analyzer, ocular
      surface disease index (OSDI), and tear breakup time (TBUT). LASIK flap was
      created using Moria microkeratome in 30 eyes (LASIK group) and using VisuMax
      femtosecond laser in 38 eyes (FS-LASIK group) and SMILE was done by VisuMax in 35
      eyes (SMILE group). Postoperative evaluation: anterior segment optical coherence
      tomography to measure flap and cap thickness, ocular response analyzer to measure
      corneal hysteresis (CH) and corneal resistance factor (CRF), OSDI, and TBUT at 1,
      3, 6, 12, 24, and 36 months after surgery. Results: This study included 103 eyes
      of 103 patients. The mean deviation of central cap or flap thickness from
      intended was statistically higher in the LASIK group (P<0.001). Both CH and CRF
      showed significant reduction postoperatively but were significantly higher in the
      SMILE group during follow up (P<0.05). The mean OSDI scores were significantly
      elevated in all groups postoperatively (P<0.01) but were significantly lower in
      the SMILE group 3 months postoperatively (P<0.05). The mean TBUT was
      significantly decreased in all groups postoperatively (P<0.01) but was
      significantly higher in the SMILE group 6 months postoperatively (P<0.05).
      Conclusion: Femtosecond laser is more accurate than microkeratomes. CH and CRF
      changes were least after SMILE. The three procedures led to significant dryness
      but for shorter duration with SMILE.

PMID- 29844657
TI  - Brachytherapy for patients with uveal melanoma: historical perspectives and
      future treatment directions.
AB  - Surgical management with enucleation was the primary treatment for uveal melanoma
      (UM) for over 100 years. The Collaborative Ocular Melanoma Study confirmed in
      2001 that globe-preserving episcleral brachytherapy for UM was safe and
      effective, demonstrating no survival difference with enucleation. Today,
      brachytherapy is the most common form of radiotherapy for UM. We review the
      history of brachytherapy in the treatment of UM and the evolution of the
      procedure to incorporate fine-needle-aspiration biopsy techniques with DNA-and
      RNA-based genetic prognostic testing.

PMID- 29844659
TI  - Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation
      of Nrf2/HO-1 and NF-kappaB/IkappaBalpha signaling pathway.
AB  - Tanshinol, a water-soluble component isolated from Salvia miltiorrhiza Bunge, has
      a variety of biological activities involving anti-fibrotic effect. However, the
      exact role and the underlying mechanisms remain largely unclear. This study
      mainly focused on the anti-hepatic fibrotic activities and mechanisms of
      tanshinol on carbon tetrachloride (CCl4)-induced liver fibrosis in rats via anti
      oxidative and anti-inflammation pathways. The rats were divided into 4 groups as
      follows: control, model, tanshinol 20 mg/kg, and tanshinol 40 mg/kg. Except for
      the control group, CCl4 was used to induce liver fibrosis processing for 8 weeks,
      meanwhile rats in tanshinol groups were intraperitoneally injected with
      additional tanshinol. Control group simultaneously received the same volumes of
      olive oil and saline. The potentially protective effect and mechanisms of
      tanshinol on liver fibrosis in rats were evaluated. The serum levels of alanine
      aminotransferase, aspartate aminotransferase, and total bilirubin were obviously
      lower in the tanshinol treatment groups related to model group. Compared with the
      model group, the levels of hyaluronic acid, type IV collagen, Laminin (LN), and
      procollagen III peptide (PIIIP) in serum were significantly decreased after
      tanshinol treatment. Furthermore, tanshinol could regulate Nrf2/HO-1 signaling
      pathway and increase the level of superoxide dismutase (SOD) and glutathione
      peroxidase (GSH-Px), and also decrease the level of malondialdehyde (MDA) to
      against damage induced by oxidative stress. Simultaneously tanshinol could
      regulate nuclear factor kappa B signaling pathway to inhibit expression of
      inflammation factors, including transforming growth factor-beta, tumor necrosis
      factor-alpha, Cox-2, interleukin-1beta, and interleukin-6. In summary, our
      research demonstrated that tanshinol has protective effect on CCl4-induced liver
      fibrosis via inhibiting oxidative stress and inflammation, which may be
      associated with the regulation of nuclear factor erythroid2-related factor
      2/hemeoxygenase-a and nuclear factor kappa B/inhibitor of kappa B alpha signaling
      pathways.

PMID- 29844660
TI  - Waiting for diagnostic colonoscopy: a qualitative exploration of screening
      participants' experiences in a FIT-based colorectal cancer screening program.
AB  - Background: Participants in population-based screening for colorectal cancer
      (CRC) may experience increased anxiety immediately after a positive screening
      test, but research in this area is limited. The objective of this study was to
      explore how screening participants experience a positive test result and cope
      with the pre-diagnostic waiting period in a CRC screening program. Materials and
      methods: Screening participants with a positive fecal immunochemical test (FIT)
      result were identified in the Danish national CRC program before they attended
      diagnostic colonoscopy. Sixteen screening participants were selected for an
      interview in their own homes, using a semi-structured interview guide.
      Transcribed data were analyzed thematically. Results: The most prominent themes
      were symptom appraisal and communication strategies. Most participants attributed
      the positive FIT result showing blood in the stool to pre-existing non-malignant
      conditions but a few were very worried about the FIT result and the outcome of
      the colonoscopy. Communication strategies included discussions with family or
      friends about the positive FIT result and the upcoming colonoscopy, or containing
      information until the colonoscopy had provided the definitive diagnostic result.
      There was no apparent need for communication with health care professionals
      during the pre-diagnostic waiting period. Conclusion: The pre-diagnostic waiting
      period between positive FIT result and colonoscopy in a population-based
      screening program may cause worry for some participants, potentially to require
      support, but most people consider it unconcerning. Screening providers should
      communicate to all screening participants in written form that negative emotional
      responses may occur after a positive screening result. This is particularly
      important in screening programs using self-sample kits without the presence of a
      health care professional to reassure the few participants who may experience
      significant anxiety.

PMID- 29844661
TI  - Quick screen of patients' numeracy and document literacy skills: the factor
      structure of the Newest Vital Sign.
AB  - Introduction: The Newest Vital Sign (NVS) is a survey designed to measure general
      health literacy whereby an interviewer asks six questions related to information
      printed on a nutritional label from an ice cream container. It enables
      researchers to evaluate several health literacy dimensions in a short period of
      time, including document literacy, comprehension, quantitative literacy
      (numeracy), application, and evaluation. No study has empirically examined which
      items belong to which latent dimensions of health literacy in the NVS using
      factor analysis. Identifying the factor structure of the NVS would enable health
      care providers to choose appropriate intervention strategies to address patients'
      health literacy as well as improve their health outcomes accordingly. This study
      aimed to explore the factor structure of the NVS that is used to assess multiple
      dimensions of health literacy. Methods: A cross-sectional study administering the
      NVS in a face-to-face manner was conducted at two family medicine clinics in the
      USA. One hundred and seventy four individuals who participated were at least 20
      years old, diagnosed with type 2 diabetes, prescribed at least one oral diabetes
      medicine, and used English as their primary language. Exploratory factor analysis
      and confirmatory factor analysis were conducted to investigate the factor
      structure of the NVS. Results: Numeracy and document literacy are two dimensions
      of health literacy that were identified and accounted for 63.05% of the variance
      in the NVS. Internal consistency (Cronbach's alpha) of the NVS were 0.78 and 0.91
      for numeracy and document literacy, respectively. Conclusion: Numeracy and
      document literacy appropriately represent the factor structure of the NVS and may
      be used for assessing health literacy in greater detail for patients with type 2
      diabetes.

PMID- 29844662
TI  - The impact of pelvic floor muscle training on the quality of life of women with
      urinary incontinence: a systematic literature review.
AB  - Purpose: The purpose of this review was to assess the effectiveness of pelvic
      floor muscle training (PFMT) in the treatment of urinary incontinence (UI) in
      women, with a particular focus on the impact of this form of therapy on the
      patients' quality of life (QoL). Methods: The following electronic databases were
      searched: PubMed, Embase, and Cochrane Library (articles only in English, 1990
      2017). Search terms were as follows: urinary incontinence, pelvic floor muscle
      training, pelvic floor exercises, quality of life. Systematic review methods were
      based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta
      Analyses) statement. Results: The assessment of the impact of PFMT on the QoL of
      women with UI was conducted among 2,394 women in 24 selected studies. After the
      end of treatment, the majority of patients in the experimental groups noted a
      statistically significant improvement in QoL. Conclusion: The results of this
      literature review demonstrate that PFMT is an effective treatment for UI in
      women. PFMT significantly improves the QoL of women with UI, which is an
      important determinant of their physical, mental, and social functioning.

PMID- 29844663
TI  - Sensory and memory stimulation as a means to care for individuals with dementia
      in long-term care facilities.
AB  - Objective: The primary objective of this study was to identify and further
      examine the facilitators and barriers of utilizing sensory and memory stimulation
      as a means to care for individuals with dementia who live in long-term care
      settings. Materials and methods: The authors conducted a literature review of 30
      academic articles found using the databases such as CINAHL, PubMed, and Academic
      Search Ultimate from the past 15 years. Facilitator and barrier themes were found
      within each article and analyzed for their relevance to sensory and memory
      stimulation therapies and their effects on individuals with dementia. Results:
      The most common facilitator was improved communication. The top three barriers
      were access, staff training, and mixed results. Discussion: Reminiscence therapy
      appears to provide a person-centered method of care for those who otherwise have
      problems communicating. These implementations will be more effective if they have
      the support of staff and management. Conclusion: The authors conclude that
      sensory and memory stimulation therapies have the potential to help improve many
      dementia-specific issues for individuals living in long-term care settings.

PMID- 29844664
TI  - Development and validation of the Medication Regimen Simplification Guide for
      Residential Aged CarE (MRS GRACE).
AB  - Background: Residents of aged care facilities use increasingly complex medication
      regimens. Reducing unnecessary medication regimen complexity (eg, by
      consolidating the number of administration times or using alternative
      formulations) may benefit residents and staff. Objective: To develop and validate
      an implicit tool to facilitate medication regimen simplification in aged care
      facilities. Method: A purposively selected multidisciplinary expert panel used
      modified nominal group technique to identify and prioritize factors important in
      determining whether a medication regimen can be simplified. The five prioritized
      factors were formulated as questions, pilot-tested using non-identifiable
      medication charts and refined by panel members. The final tool was validated by
      two clinical pharmacists who independently applied the tool to a random sample of
      50 residents of aged care facilities to identify opportunities for medication
      regimen simplification. Inter-rater agreement was calculated using Cohen's kappa.
      Results: The Medication Regimen Simplification Guide for Residential Aged CarE
      (MRS GRACE) was developed as an implicit tool comprising of five questions about
      1) the resident; 2) regulatory and safety requirements; 3) drug interactions; 4)
      formulation; and 5) facility and follow-up considerations. Using MRS GRACE, two
      pharmacists independently simplified medication regimens for 29/50 and 30/50
      residents (Cohen's kappa=0.38, 95% CI 0.12-0.64), respectively. Simplification
      was possible for all residents with five or more administration times. Changing
      an administration time comprised 75% of the two pharmacists' recommendations.
      Conclusions: Using MRS GRACE, two clinical pharmacists independently simplified
      over half of residents' medication regimens with fair agreement. MRS GRACE is a
      promising new tool to guide medication regimen simplification in aged care.

PMID- 29844665
TI  - Age-related changes in shock absorption capacity of the human spinal column.
AB  - Background: The spinal column possesses shock absorption properties, mainly
      provided by the intervertebral discs. However, with the process of senescence,
      all structures of the spine, including the discs, undergo degenerative changes.
      It may lead to alteration of the mechanical properties of the spinal motion
      segment and diminished capacity for vibration attenuation. Objective: The
      objective of this study was to investigate the age-related changes in shock
      absorption properties of the spine. Patients and methods: A total of 112
      individuals divided into three groups according to age (third, fifth, and seventh
      decades of life) were enrolled in this study. The transmissibility of vibrations
      through the spine was measured in a standing position on a vibration platform by
      accelerometers mounted at the levels of S2 and C0. Registered signals were
      described using four parameters: VMS (variability), peak-to-peak amplitude (PPA),
      and spectral activity in two bands F2 (0.7-5 Hz) and F20 (15-25 Hz). Results: In
      all age groups, signals registered at C0 were characterized by significantly
      lower values of VMS, PPA, and F20, when compared to level S2. Simultaneously, the
      parameter F20 significantly differed among all age groups when C0 vibrations were
      analyzed: 2.43+/-1.93, 5.02+/-3.61, and 10.84+/-5.12 for the third, fifth, and
      seventh decades of life, respectively. Conclusion: The human spinal column
      provides vibration attenuation; however, this property gradually declines with
      the aging process.

PMID- 29844666
TI  - Exercise response to oxygen supplementation is not associated with survival in
      hypoxemic patients with obstructive lung disease.
AB  - Purpose: Hypoxemia is associated with more severe lung disease and worse
      outcomes. In some patients with chronic obstructive lung diseases who desaturate
      on exertion, supplemental oxygen improves exercise capacity. The clinical
      significance of this exercise response to oxygen supplementation is not known.
      Patients and methods: We identified chronic obstructive lung disease patients at
      our center who underwent a 6-minute walking test (6MWT) for ambulatory oxygen
      assessment and who desaturated breathing air and therefore had an additional walk
      test on supplemental oxygen, between August 2006 and June 2016. Responders were
      defined as walking >=26 m further with oxygen. Survival was determined up to
      February 1, 2017. We compared survival in oxygen responders and nonresponders in
      patients with obstructive lung diseases. Results: One hundred and seventy-four
      patients were included in the study, median age 70 years. Seventy-seven (44.3%)
      of the patients were oxygen responders. Borg dyspnea score improved by 1.4 (+/
      1.4) units (P<0.0005) on oxygen. Median survival was 66 months with death
      occurring in 84 (48.2%) patients. Kaplan-Meier analysis revealed no survival
      difference between both responders and nonresponders (P=0.571). Cox regression
      analysis showed that more 6MWT desaturation, lower 6-minute walking distance on
      room air, male gender, lower hemoglobin, and body mass index were associated with
      higher mortality risk. Conclusion: Acute exercise response to supplemental oxygen
      is not associated with long-term survival in patients with obstructive lung
      disease. This supports the use of ambulatory oxygen treatment for symptomatic
      purposes only.

PMID- 29844667
TI  - Distribution and characteristics of COPD phenotypes - results from the Polish sub
      cohort of the POPE study.
AB  - Background: This study aimed to examine the distribution of predefined
      phenotypes, demographic data, clinical outcomes, and treatment of patients who
      were included in the Polish cohort of the Phenotypes of COPD in Central and
      Eastern Europe (POPE) study. Patients and methods: This was a sub-analysis of the
      data from the Polish cohort of the POPE study, an international, multicenter,
      observational cross-sectional survey of COPD patients in Central and Eastern
      European countries. The study included patients aged >40 years, with a confirmed
      diagnosis of COPD, and absence of exacerbation for at least 4 weeks before study
      inclusion. A total of seven Polish centers participated in the study. Results:
      Among the 430 Polish COPD patients enrolled in the study, 61.6% were non
      exacerbators (NON-AE), 25.3% were frequent exacerbators with chronic bronchitis
      (AE CB), 7.9% were frequent exacerbators without chronic bronchitis (AE NON-CB),
      and 5.1% met the definition of asthma-COPD overlap syndrome (ACOS). There were
      statistically significant differences among these phenotypes in terms of symptom
      load, lung function, comorbidities, and treatment. Patients with the AE CB
      phenotype were most symptomatic with worse lung function, and more frequently
      reported anxiety and depression. Patients with the ACOS phenotype were
      significantly younger and were diagnosed with COPD earlier than those with other
      COPD phenotypes; those with the ACOS phenotype were also more often atopic and
      obese. Conclusion: There is significant heterogeneity among COPD patients in the
      Polish population in terms of phenotype and clinical outcome. The non-exacerbator
      phenotype is observed most frequently in Poland, while the frequent exacerbator
      with chronic bronchitis phenotype is the most symptomatic.

PMID- 29844668
TI  - Case-finding for COPD in primary care: a qualitative study of patients'
      perspectives.
AB  - Background: COPD is a leading cause of morbidity and mortality, yet it remains
      largely under-diagnosed. Case-finding is encouraged by many professionals, but
      there is a lack of information on the patients' views and perspectives. Patients
      and methods: Semistructured interviews were conducted with adults, aged 40 years
      or older with a history of smoking, who were eligible and invited for case
      finding for COPD as a part of a large UK primary care trial. Patients, including
      those who consented or declined participation and those with and without COPD
      after screening, were interviewed. Interviews were transcribed and analyzed using
      the framework method. Results: The 43 interviews revealed the following two main
      categories of themes: patients' views on COPD case-finding and barriers to case
      finding. Overall, case-finding was deemed important and beneficial. Participants
      highlighted the need for screening activities to be convenient for patients but
      perceived that general practitioners (GPs) lacked the time and accessing
      appointments was difficult. Desire for a health check among symptomatic patients
      facilitated participation in case-finding. Psychological barriers to engagement
      included denial of ill health or failure to recognize symptoms, fear of the
      "test", and lung symptoms being low on the hierarchy of patient health
      complaints. Mechanical barriers included providing care for another person (and
      therefore being too busy), being unable to access GP appointments, and lacking
      feedback of spirometry results or communication of the diagnosis. Conclusion:
      Patient engagement with case-finding may be limited by denial or lack of
      recognition of symptoms and physical barriers to attendance. Increasing public
      awareness of COPD risk factors and early symptoms may enhance case-finding.

PMID- 29844669
TI  - Responses of intestinal virome to silver nanoparticles: safety assessment by
      classical virology, whole-genome sequencing and bioinformatics approaches.
AB  - Background: Effects of silver nanoparticles (AgNP) on the intestinal virome/phage
      community are mostly unknown. The working hypothesis of this study was that the
      exposure of pharmaceutical/nanomedicine and other consumer-use material
      containing silver ions and nanoparticles to the gastrointestinal tract may result
      in disturbance of the beneficial gut viruses/phages. Methods: This study assesses
      the impact of AgNP on the survival of individual bacteriophages using classical
      virology cultivation and electron microscopic techniques. Moreover, how the
      ingested AgNP may affect the intestinal virus/phages was investigated by
      conducting whole-genome sequencing (WGS). Results: The viral cultivation methods
      showed minimal effect on selected viruses during short-term exposure (24 h) to 10
      nm AgNP. However, long-term exposure (7 days) resulted in significant reduction
      in the viral/phage population. Data obtained from WGS were filtered and compared
      with a nonredundant viral database composed of the complete viral genomes from
      NCBI using KRAKEN (confidence scoring threshold of 0.5). To compare the relative
      differential changes, the sequence counts in each treatment group were normalized
      to account for differences in DNA sequencing library sizes. Bioinformatics
      techniques were developed to visualize the virome comparative changes in a
      phylogenic tree graph. The computed data revealed that AgNP had an impact on
      several intestinal bacteriophages that prey on bacterial genus Enterobacteria,
      Yersinia and Staphylococcus as host species. Moreover, there was an independent
      effect of nanoparticles and released ions. Conclusion: Overall, this study
      reveals that the small-size AgNP could lead to perturbations of the gut microbial
      ecosystem, leading to the inactivation of resident phages that play an important
      role in influencing gastrointestinal health.

PMID- 29844670
TI  - Formulation and evaluation of mixed polymeric micelles of quercetin for treatment
      of breast, ovarian, and multidrug resistant cancers.
AB  - Background: Quercetin (QCT), a naturally occurring flavonoid has a wide array of
      pharmacological properties such as anticancer, antioxidant and anti-inflammatory
      activities. QCT has low solubility in water and poor bioavailability, which
      limited its use as a therapeutic molecule. Polymeric micelles (PMs) is a novel
      drug delivery system having characteristics like smaller particle size, higher
      drug loading, sustained drug release, high stability, increased cellular uptake
      and improved therapeutic potential. In the present study, we have formulated and
      characterized mixed PMs (MPMs) containing QCT for increasing its anticancer
      potential. Methods: The MPMs were prepared by thin film hydration method, and
      their physicochemical properties were characterized. The in vitro anticancer
      activity of the MPMs were tested in breast (MCF-7 and MDA-MB-231, epithelial and
      metastatic cancer cell lines, respectively), and ovarian (SKOV-3 and NCI/ADR,
      epithelial and multi-drug resistant cell lines, respectively) cancer. Results:
      The optimal MPM formulations were obtained from Pluronic polymers, P123 and P407
      with molar ratio of 7:3 (A16); and P123, P407 and TPGS in the molar ratio of
      7:2:1 (A22). The size of the particles before lyophilization (24.83+/-0.44 nm)
      and after lyophilisation (37.10+/-4.23 nm), drug loading (8.75+/-0.41%), and
      encapsulation efficiency (87.48+/-4.15%) for formulation A16 were determined. For
      formulation A22, the particle size before lyophilization, after lyophilization,
      drug loading and encapsulation efficiency were 26.37+/-2.19 nm, 45.88+/-13.80 nm,
      9.01+/-0.11% and 90.07+/-1.09%, respectively. The MPMs exhibited sustained
      release of QCT compared to free QCT as demonstrated from in vitro release
      experiments. The solubility of QCT was markedly improved compared to pure QCT.
      The MPMs were highly stable in aqueous media as demonstrated by their low
      critical micelle concentration. The concentration which inhibited 50% growth
      (IC50) values of both micellar preparations in all the cancer cell lines were
      significantly less compared to free QCT. Conclusion: Both the MPMs containing QCT
      could be used for effective delivery to different type of cancer and may be
      considered for further development.

PMID- 29844671
TI  - Hierarchically aligned fibrin nanofiber hydrogel accelerated axonal regrowth and
      locomotor function recovery in rat spinal cord injury.
AB  - Background: Designing novel biomaterials that incorporate or mimic the functions
      of extracellular matrix to deliver precise regulatory signals for tissue
      regeneration is the focus of current intensive research efforts in tissue
      engineering and regenerative medicine. Methods and results: To mimic the natural
      environment of the spinal cord tissue, a three-dimensional hierarchically aligned
      fibrin hydrogel (AFG) with oriented topography and soft stiffness has been
      fabricated by electrospinning and a concurrent molecular self-assembling process.
      In this study, the AFG was implanted into a rat dorsal hemisected spinal cord
      injury model to bridge the lesion site. Host cells invaded promptly along the
      aligned fibrin hydrogels to form aligned tissue cables in the first week, and
      then were followed by axonal regrowth. At 4 weeks after the surgery,
      neurofilament (NF)-positive staining fibers were detected near the rostral end as
      well as the middle site of defect, which aligned along the tissue cables.
      Abundant NF- and GAP-43-positive staining indicated new axon regrowth in the
      oriented tissue cables, which penetrated throughout the lesion site in 8 weeks.
      Additionally, the abundant blood vessels marked with RECA-1 had reconstructed
      within the lesion site at 4 weeks after surgery. Basso-Beattie-Bresnahan scoring
      showed that the locomotor performance of the AFG group recovered much faster than
      that of blank control group or the random fibrin hydrogel (RFG) group from 2
      weeks after surgery. Furthermore, diffusion tensor imaging tractography of MRI
      confirmed the optimal axon fiber reconstruction compared with the RFG and control
      groups. Conclusion: Taken together, our results suggested that the AFG scaffold
      provided an inductive matrix for accelerating directional host cell invasion,
      vascular system reconstruction, and axonal regrowth, which could promote and
      support extensive aligned axonal regrowth and locomotor function recovery.

PMID- 29844672
TI  - Recent advances in functional nanostructures as cancer photothermal therapy.
AB  - Being a non-invasive and relatively safe technique, photothermal therapy has
      attracted a lot of interest in the cancer treatment field. Recently,
      nanostructure technology has entered the forefront of cancer therapy owing to its
      ability to absorb near-infrared radiation as well as efficient light to heat
      conversion. In this study, key nanostructures for cancer therapy including gold
      nanoparticles, magnetite iron oxide nanoparticles, organic nanomaterials, and
      novel two-dimensional nanoagents such as MXenes are discussed. Furthermore, we
      briefly discuss the characteristics of the nanostructures of these photothermal
      nanomaterial agents, while focusing on how nanostructures hold potential as
      cancer therapies. Finally, this review offers promising insight into new cancer
      therapy approaches, particularly in vivo and in vitro cancer treatments.

PMID- 29844673
TI  - Mechanisms of oxidative stress, apoptosis, and autophagy involved in graphene
      oxide nanomaterial anti-osteosarcoma effect.
AB  - Background: Graphene and its derivative graphene oxide (GO) have been implicated
      in a wide range of anticancer effects. Purpose: The objective of this study was
      to systematically evaluate the toxicity and underlying mechanisms of GO on two
      osteosarcoma (OSA) cancer cell lines, MG-63 and K7M2 cells. Methods: MG-63 and
      K7M2 cells were treated by GO (0-50 ug/mL) for various time periods. Cell
      viability was tested by MTT and Live/Dead assays. A ROS Detection Kit based on
      DHE oxidative reaction was used for ROS detection. An Annexin V-FITC Apoptosis
      Kit was used for apoptosis detection. Dansylcadaverine (MDC) dyeing was applied
      for seeking unspecific autophagosomes. Western blot and Immunofluorescence
      analysis were used for related protein expression and location. Results: K7M2
      cells were more sensitive to GO compared with MG-63 cells. The mechanism was
      attributed to the different extent of the generation of reactive oxygen species
      (ROS). In K7M2 cells, ROS was easily stimulated and the apoptosis pathway was
      subsequently activated, accompanied by elevated expression of proapoptosis
      proteins (such as caspase-3) and decreased expression levels of antiapoptosis
      proteins (such as Bcl-2). A ROS inhibitor (N-acetylcysteine) could alleviate the
      cytotoxic effects of GO in K7M2 cells. However, the production of ROS in MG-63
      cells was probably inhibited by the activation of an antioxidative factor,
      nuclear factor-E2-related factor-2, which translocated from the cytoplasm to the
      nucleus after GO treatment, while a nuclear factor-E2-related factor-2 inhibitor
      (ML385) significantly increased ROS production in MG-63 cells when combined with
      GO treatment. In addition, autophagy was simultaneously stimulated by
      characteristic autophagosome formation, autophagy flux, and increased the
      expression level of autophagy-related proteins (such as LC3I to LC3II conversion,
      ATG5, and ATG7). Conclusion: This paper proposes various underlying mechanisms of
      the anticancer effect of GO. The novel synthetic use of GO with an oxidizing
      agent is the key step for further potential applications in clinical OSA cancer
      therapy.

PMID- 29844674
TI  - Factors impacting the efficacy of venlafaxine extended release 75-225 mg/day in
      patients with major depressive disorder: exploratory post hoc subgroup analyses
      of a randomized, double-blind, placebo-controlled study in Japan.
AB  - Purpose: To explore the potential factors impacting the efficacy of venlafaxine
      extended release (ER) and treatment differences between 75 mg/day and 75-225
      mg/day dose in patients with major depressive disorder (MDD). Methods: We
      performed exploratory post hoc subgroup analyses of a randomized, double-blind,
      placebo-controlled study conducted in Japan. A total of 538 outpatients aged 20
      years or older with a primary diagnosis of MDD who experienced single or
      recurrent episodes were randomized into three groups: fixed-dose, flexible-dose,
      or placebo. Venlafaxine ER was initiated at 37.5 mg/day and titrated to 75 mg/day
      for both fixed-dose and flexible-dose group, and to 225 mg/day for flexible-dose
      group (if well tolerated). Efficacy endpoints were changes from baseline at Week
      8 using the Hamilton Rating Scale for Depression-17 items (HAM-D17) total score,
      Hamilton Rating Scale for Depression-6 items score, and Montgomery-Asberg
      Depression Rating Scale total score. The following factors were considered in the
      subgroup analyses: sex, age, HAM-D17 total score at baseline, duration of MDD,
      duration of current depressive episode, history of previous depressive episodes,
      history of previous medications for MDD, and CYP2D6 phenotype. For each subgroup,
      an analysis of covariance model was fitted and the adjusted mean of the treatment
      effect and corresponding 95% CI were computed. Due to the exploratory nature of
      the investigation, no statistical hypothesis testing was used. Results:
      Venlafaxine ER improved symptoms of MDD compared with placebo in most subgroups.
      The subgroup with a long duration of MDD (>22 months) consistently showed greater
      treatment benefits in the flexible-dose group than in the fixed-dose group.
      Conclusion: These results suggest that a greater treatment response to
      venlafaxine ER (up to 225 mg/day) can be seen in patients with a longer duration
      of MDD. Further investigations are needed to identify additional factors
      impacting the efficacy of venlafaxine ER.

PMID- 29844675
TI  - Harm avoidance and depression, anxiety, insomnia, and migraine in fifth-year
      medical students in Taiwan.
AB  - Purpose: During medical school training, increased stress, depression, and
      anxiety are common. Certain personality traits, particularly harm avoidance (HA),
      may increase the risk of psycho-pathological disorders, insomnia, and migraine
      among medical students. This study evaluated the role HA may play on levels of
      stress, depression, anxiety, and insomnia among Taiwanese medical students
      starting their fifth and final year of medical school. Patients and methods: A
      series of self-report questionnaires were used to measure the severity of
      anxiety, depression, and insomnia, as well as somatic symptoms, particularly
      migraine headache, among 143 Taiwanese fifth-year medical students (94 males and
      49 females). Most had normal or mild levels of anxiety, depression, insomnia, and
      migraine. Results: HA personality trait was significantly associated with
      depression (all P <= 0.001) after adjusting for other factors. HA was not
      significantly associated with anxiety, insomnia, or migraine headache days.
      Conclusion: HA personality trait was significantly associated with depression
      among fifth-year medical students in Taiwan.

PMID- 29844676
TI  - Enhancing research publications and advancing scientific writing in health
      research collaborations: sharing lessons learnt from the trenches.
AB  - Background: Disseminating research protocols, processes, methods or findings via
      peer-reviewed publications has substantive merits and benefits to various
      stakeholders. Purpose: In this article, we share strategies to enhance research
      publication contents (ie, what to write about) and to facilitate scientific
      writing (ie, how to write) in health research collaborations. Methods: Empirical
      experience sharing. Results: To enhance research publication contents, we
      encourage identifying appropriate opportunities for publications, publishing
      protocols ahead of results papers, seeking publications related to methodological
      issues, considering justified secondary analyses, and sharing academic process or
      experience. To advance writing, we suggest setting up scientific writing as a
      goal, seeking an appropriate mentorship, making full use of scientific meetings
      and presentations, taking some necessary formal training in areas such as
      effective communication and time and stress management, and embracing the
      iterative process of writing. Conclusion: All the strategies we share are
      dependent upon each other; and they advocate gradual academic accomplishments
      through study and training in a "success-breeds-success" way. It is expected that
      the foregoing shared strategies in this paper, together with other previous
      guidance articles, can assist one with enhancing research publications, and
      eventually one's academic success in health research collaborations.

PMID- 29844677
TI  - The Influence of Nicotinamide on Health and Disease in the Central Nervous
      System.
AB  - Nicotinamide, the amide form of vitamin B3 (niacin), has long been associated
      with neuronal development, survival, and function in the central nervous system
      (CNS), being implicated in both neuronal death and neuroprotection. Here, we
      summarise a body of research investigating the role of nicotinamide in neuronal
      health within the CNS, with a focus on studies that have shown a neuroprotective
      effect. Nicotinamide appears to play a role in protecting neurons from traumatic
      injury, ischaemia, and stroke, as well as being implicated in 3 key
      neurodegenerative conditions: Alzheimer's, Parkinson's, and Huntington's
      diseases. A key factor is the bioavailability of nicotinamide, with low
      concentrations leading to neurological deficits and dementia and high levels
      potentially causing neurotoxicity. Finally, nicotinamide's potential mechanisms
      of action are discussed, including the general maintenance of cellular energy
      levels and the more specific inhibition of molecules such as the nicotinamide
      adenine dinucleotide-dependent deacetylase, sirtuin 1 (SIRT1).

PMID- 29844678
TI  - Peritoneal carcinomatosis index as a predictor of diaphragmatic involvement in
      stage III and IV ovarian cancer.
AB  - Objective: To analyze the surgical outcomes and diaphragmatic involvement in
      stage III and IV ovarian cancer. Patients and methods: All patients with stage
      III-IV ovarian cancer between January 2013 and January 2016 were included. The
      outcomes of interest reviewed were as follows: surgical (complications,
      mortality), peritoneal carcinomatosis index (PCI), rate of complete resection,
      and disease-free interval and survival. Results: Fifty-seven patients were
      included, 38 (67%) with diaphragmatic involvement; in 10 cases (18%),
      diaphragmatic resection was required. Optimal cytoreduction (OCR) was obtained in
      49 cases (86%). The PCI was >10 in 31 cases (54%). Respiratory complications
      occurred in 10 cases (18%) and mortality in 3 (5%). Disease-free survival rate in
      3 years was 53%, being 87% in cases without diaphragmatic involvement. The
      overall survival rate in 3 years is 46%, 83% in the cases without diaphragmatic
      involvement and 27% in cases with affectation (p<0.05). In cases of OCR, 3 year
      survival rate was 65%. In the multivariate analysis for the overall survival of
      cases with OCR, the only independent prognostic factor found was the operative
      PCI. A strong correlation was found between the total PCI and the diaphragmatic
      PCI (p<0.001). With a PCI >10, virtually all cases will present diaphragmatic
      involvement (p<0.05). Conclusion: The tumor burden is different in stages III and
      IV of advanced ovarian cancer and the PCI is an effective method to quantify it.
      The PCI constitutes an independent prognostic factor for the advanced stages of
      ovarian cancer. A PCI >10 constitutes a useful prognostic factor of the
      affectation and forces the surgeon to thoroughly review both diaphragms.

PMID- 29844679
TI  - 5-Azacytidine treatment induces demethylation of DAPK1 and MGMT genes and
      inhibits growth in canine mammary gland tumor cells.
AB  - Background: Canine mammary gland tumors (CMGTs) are the most common, spontaneous
      types of neoplasias in female dogs. Aberrant DAPK1 and MGMT methylation
      associated with tumor formation and development in various cancers. 5-Azacytidine
      is a known specific demethylation drug that covalently binds to DNA
      methyltransferase. However, the methylation of the DAPK1 and MGMT is unknown with
      respect to CMGTs. Therefore, we sought to demonstrate the effects of 5
      azacytidine on the proliferation of CMGTs cell, and elucidate the potential
      molecular mechanisms of action in these cancerous cells. Materials and methods:
      The effects of 5-azacytidine on CHMm and CHMp cell proliferation were evaluated
      by MTT assay. The DAPK1 and MGMT gene methylation patterns in CHMm and CHMp cells
      and CMGTs blood/tissue samples were analyzed by MSP assay. Effect of 5
      azacytidine on the methylation of DAPK1 and MGMT gene, and DAPK1 and MGMT mRNA
      expression in CHMm and CHMp cells were analyzed by MSP assay and qRT-PCR assay,
      respectively. Results: 5-Azacytidine may suppress the proliferation of CHMm and
      CHMp cells. Furthermore, the DAPK1 and MGMT genes were hypermethylated in
      CHMm/CHMp cells and clinical malignant tumor samples, but not in normal female
      dogs' blood and tissue. However, the DAPK1 and MGMT genes were re-inducible in
      CHMm and CHMp cells treated with 5 MUM 5-azacytidine. Meanwhile, 5-azacytidine
      increased the expression of DAPK1 and MGMT mRNA. Conclusion: These results
      suggest that DAPK1 and MGMT methylation can serve as sensitive diagnostic
      biomarkers and therapeutic targets for CMGTs. 5-Azacytidine also could be a
      potential therapeutic candidate for CMGTs.

PMID- 29844680
TI  - Identifying miRNA and gene modules of colon cancer associated with pathological
      stage by weighted gene co-expression network analysis.
AB  - Introduction: Colorectal cancer (CRC) is the fourth most common cause of cancer
      related mortality worldwide. The tumor, node, metastasis (TNM) stage remains the
      standard for CRC prognostication. Identification of meaningful microRNA (miRNA)
      and gene modules or representative biomarkers related to the pathological stage
      of colon cancer helps to predict prognosis and reveal the mechanisms behind
      cancer progression. Materials and methods: We applied a systems biology approach
      by combining differential expression analysis and weighted gene co-expression
      network analysis (WGCNA) to detect the pathological stage-related miRNA and gene
      modules and construct a miRNA-gene network. The Cancer Genome Atlas (TCGA) colon
      adenocarcinoma (CAC) RNA-sequencing data and miRNA-sequencing data were subjected
      to WGCNA analysis, and the GSE29623, GSE35602 and GSE39396 were utilized to
      validate and characterize the results of WGCNA. Results: Two gene modules
      (Gmagenta and Ggreen) and one miRNA module were associated with the pathological
      stage. Six hub genes (COL1A2, THBS2, BGN, COL1A1, TAGLN and DACT3) were related
      to prognosis and validated to be associated with the pathological stage. Five hub
      miRNAs were identified to be related to prognosis (hsa-miR-125b-5p, hsa-miR-145
      5p, hsa-let-7c-5p, hsa-miR-218-5p and hsa-miR-125b-2-3p). A total of 18 hub genes
      and seven hub miRNAs were predominantly expressed in tumor stroma. Proteoglycans
      in cancer, focal adhesion, extracellular matrix (ECM)-receptor interaction and so
      on were common pathways of the three modules. Hsa-let-7c-5p was located at the
      core of miRNA-gene network. Conclusion: These findings help to advance the
      understanding of tumor stroma in the progression of CAC and provide prognostic
      biomarkers as well as therapeutic targets.

PMID- 29844681
TI  - Advances of exosome in the development of ovarian cancer and its diagnostic and
      therapeutic prospect.
AB  - Ovarian cancer is the leading cause of female gynecological cancer mortality.
      Most patients with ovarian cancer are diagnosed with advanced stage because of
      lack of early symptoms, physical signs, and sensitive tumor biomarkers. The
      standard treatment includes cytoreductive surgery and platinum-based chemotherapy
      (usually platinum combined with paclitaxel). Despite that postoperative adjuvant
      chemotherapy prolongs survival time, most patients go through relapse within 6-12
      months after the treatment. Thus, elucidating the molecular mechanism in cancer
      development is essential to promote early diagnosis and novel treatments. The
      role of exosome has been highlighted in multiple research fields in recent years.
      Exosome has been described as nano-sized vesicle secreted by multiple mammalian
      cell types, carrying cargos like proteins, miRNAs, mRNAs, and lipids. It
      participates in the formation of tumor microenvironment and the development of
      tumorigenesis and drug resistance in ovarian cancer. Meanwhile, it may also play
      a pivotal role in diagnosis, efficacy evaluation, and prognosis. Besides, studies
      show that exosome and its processed products have promising value in ovarian
      cancer treatment. The aim of the current review is to describe the
      characteristics of exosome in ovarian cancer, especially focusing on its role in
      immune modulation and drug resistance, hoping to provide new information on its
      implications in cancer diagnosis and treatment.

PMID- 29844682
TI  - NDRG3 facilitates colorectal cancer metastasis through activating Src
      phosphorylation.
AB  - Background: NDRG3 is an N-myc downregulated gene (NDRG). The aim of this article
      was to identify the role of NDRG3 in colorectal cancer (CRC) and to determine the
      mechanism underlying its function. Methods: Using immunohistochemical staining,
      expression and clinicopathological variables of NDRG3 were analyzed in 170 CRC
      samples. Overexpression of NDRG3 was employed in SW1116 cells, downregulation of
      NDRG3 was achieved in RKO cells, then migration and invasion assays were
      performed in vitro, and a mouse model was constructed in vivo. Results: Increased
      expression of NDRG3 was observed in primary CRC tissues, and this expression was
      correlated with distant metastasis. Consistently, ectopic expression of NDRG3 in
      SW1116 cells enhanced cell migration and invasion, while knockdown of NDRG3 in
      RKO cells significantly suppressed CRC cell metastasis. The portal vein injection
      models suggested that NDRG3 overexpression facilitates liver metastasis. These
      events were associated with the phosphorylation of Src (c-Src) at Tyr 419 site.
      Conclusion: Our results showed that NDRG3 facilitates CRC migration and invasion
      by activating Src phosphorylation, suggesting the role of NDRG3 as a candidate
      oncogene.

PMID- 29844683
TI  - circSMAD2 inhibits the epithelial-mesenchymal transition by targeting miR-629 in
      hepatocellular carcinoma.
AB  - Background: Circular RNAs (circRNAs) are a class of widely distributed non-coding
      RNAs, which drew little attention for decades. Recent studies show that circRNAs
      are involved in cancer progression. Methods: The circSMAD2 expression in HCC and
      adjacent non-tumor tissues was measured by quantitative real-time polymerase
      chain reaction, and the biological function of circSMAD2 was explored by
      proliferation, apoptosis, migration, invasion, and Western blot assays. Next, the
      dual-luciferase reporter assay was performed to identify the target miRNA of
      circSMAD2. Finally, circSMAD2 and its target miRNA were co-transfected in HCC
      cells to investigate their relationship to HCC progression. Results: In this
      study, we found that circRNA SMAD2 (circSMAD2) expression was downregulated in
      hepatocellular carcinoma (HCC) tissues (P = 0.014) compared to the adjacent non
      tumor tissues and markedly associated with the differentiation degree of the HCC
      tissues (P < 0.001). The in vitro experiments showed that overexpressed circSMAD2
      inhibited the migration, invasion, and epithelial-mesenchymal transition (EMT) in
      HCC cells. Bioinformatics predicted that miR-629 is a potential target of
      circSMAD2, and the dual-luciferase reporter assay verified that miR-629 directly
      bound circSMAD2. In addition, we found that overexpression of circSMAD2
      suppressed the expression of miR-629 in HCC cells, whereas knockdown of circSMAD2
      upregulated the expression of miR-629. Furthermore, co-transfection of miR-629
      mimics with circSMAD2 reversed the circSMAD2 effects of inhibiting the migration,
      invasion, and EMT of HCC cells. Conclusion: Altogether, our data support that
      circSMAD2 inhibits the migration, invasion, and EMT of HCC cells by targeting miR
      629.

PMID- 29844684
TI  - Leaflet manual of external beam radiation therapy for hepatocellular carcinoma: a
      review of the indications, evidences, and clinical trials.
AB  - The use of external beam radiation therapy (EBRT) in the treatment of
      hepatocellular carcinoma (HCC), which was rarely performed due to liver toxicity
      with a previous technique, has increased. Palliation of portal vein thrombosis,
      supplementation for insufficient transarterial chemoembolization, and provision
      of new curative opportunities using stereotactic body radiotherapy are the
      potential indications for use of EBRT. The mechanism of EBRT treatment, with its
      radiobiological and physical perspectives, differs from those of conventional
      medical treatment or surgery. Therefore, understanding the effects of EBRT may be
      unfamiliar to physicians other than radiation oncologists, especially in the
      field of HCC, where EBRT has recently begun to be applied. The first objective of
      this review was to concisely explain the indications for use of EBRT for HCC for
      all physicians treating HCC. Therefore, this review focuses on the therapeutic
      outcomes rather than the detailed biological and physical background. We also
      reviewed recent clinical trials that may extend the indications for use of EBRT.
      Finally, we reviewed the current clinical practice guidelines for the treatment
      of HCC and discuss the current recommendations and future perspectives.

PMID- 29844685
TI  - RIP1 regulates TNF-alpha-mediated lymphangiogenesis and lymphatic metastasis in
      gallbladder cancer by modulating the NF-kappaB-VEGF-C pathway.
AB  - Background: Tumor necrosis factor alpha (TNF-alpha) enhances lymphangiogenesis in
      gallbladder carcinoma (GBC) via activation of nuclear factor (NF-kappaB)
      dependent vascular endothelial growth factor-C (VEGF-C). Receptor-interacting
      protein 1 (RIP1) is a multifunctional protein in the TNF-alpha signaling pathway
      and is highly expressed in GBC. However, whether RIP1 participates in the
      signaling pathway of TNF-alpha-mediated VEGF-C expression that enhances
      lymphangiogenesis in GBC remains unclear. Methods: The RIP1 protein levels in the
      GBC-SD and NOZ cells upon stimulation with increasing concentrations of TNF-alpha
      as indicated was examined using Western blot. Lentiviral RIP1 shRNA and
      siIkappaBalpha were constructed and transduced respectively them into NOZ and GBC
      SD cells, and then PcDNA3.1-RIP1 vectors was transduced into siRIP1 cell lines to
      reverse RIP1 expression. The protein expression of RIP1, inhibitor of NF-kappaB
      alpha (IkappaBalpha), p-IkappaBalpha, TAK1, NF-kappaB essential modulator were
      examined through immunoblotting or immunoprecipitation. Moreover, VEGF-C mRNA
      levels were measured by quantitative real-time polymerase chain reaction, VEGF-C
      protein levels were measured by immunoblotting and enzyme-linked immunosorbent
      assay, and VEGF-C promoter and NF-kappaB activities were quantified using a dual
      luciferase reporter assay. The association of NF-kappaB with the VEGF-C promoter
      was analysed by chromatin immunoprecipitation assay. A three-dimensional
      coculture method and orthotopic transplantation nude mice model were used to
      evaluate lymphatic tube-forming and metastasis ability in GBC cells. The
      expression of RIP1 protein, TNF-alpha protein and lymphatic vessels in human GBC
      tissues was examined by immunohistochemistry, and the dependence between RIP1
      protein with TNF-alpha protein and lymphatic vessel density was analysed.
      Results: TNF-alpha dose- and time-dependently increased RIP1 protein expression
      in the GBC-SD and NOZ cells of GBC, and the strongest effect was observed with a
      concentration of 50 ng/ml. RIP1 is fundamental for TNF-alpha-mediated NF-kappaB
      activation in GBC cells and can regulate TNF-alpha-mediated VEGF-C expression at
      the protein and transcriptional levels through the NF-kappaB pathway. RIP1 can
      regulate TNF-alpha-mediated lymphatic tube formation and metastasis in GBC cells
      both in vitro and vivo. The average optical density of RIP1 was linearly related
      to that of TNF-alpha protein and the lymphatic vessel density in GBC tissues.
      Conclusion: We conclude that RIP1 regulates TNF-alpha-mediated lymphangiogenesis
      and lymph node metastasis in GBC by modulating the NF-kappaB-VEGF-C pathway.

PMID- 29844686
TI  - Bacillus Calmette-Guerin and anti-PD-L1 combination therapy boosts immune
      response against bladder cancer.
AB  - Background: Programmed death-ligand 1 (PD-L1) is a critical immune checkpoint
      molecule which promotes immunosuppression by binding to PD-1 on T-cells in tumor
      immunity. We have previously identified that activation of toll like receptor 4
      (TLR-4), which serves an important role in the induction of antitumor immune
      response during Bacillus Calmette-Guerin (BCG) immunotherapy, could upregulate PD
      L1 expression in bladder cancer (BCa) cells through the classical mitogen
      activated protein kinase (MAPK) pathway and subsequently weaken the cytotoxicity
      of cytotoxic T lymphocyte (CTL). It is, therefore, necessary to investigate the
      possible potential relationship between PD-L1 expression and BCG immunotherapy.
      Materials and methods: In this study we investigated the effects of BCG treatment
      on PD-L1 expression in BCa cells and also evaluated the efficacy of BCG and anti
      PD-L1 combination therapy in immunocompetent orthotopic rat BCa models. Results:
      We found that PD-L1 expression was obviously upregulated in BCa cells in response
      to BCG treatment both in vitro and in vivo. Moreover, BCG and anti-PD-L1
      combination treatment activated a potent antitumor immune response with the
      increase in the number and activity of tumor-infiltrating CD8+ T cells, as well
      as the reduction in myeloid-derived suppressor cells (MDSCs), and eventually
      elicits prominent tumor growth inhibition and prolonged survival, and was found
      to be much more effective than either agent alone. Conclusion: These findings
      highlight the adaptive dynamic regulation of PD-L1 in response to BCG
      immunotherapy and suggest that combination of BCG immunotherapy with PD-L1
      blockade may be an effective antitumor strategy for improving treatment outcomes
      of BCa.

PMID- 29844687
TI  - High neutrophil to lymphocyte ratio and decreased CD69+NK cells represent a
      phenotype of high risk in early-stage breast cancer patients.
AB  - Purpose: Breast cancer (BC) is a highly heterogeneous disease presenting a broad
      range of clinical and molecular characteristics. In the past years, a growing
      body of evidence demonstrated that immune response plays a significant role in
      cancer outcome. However, immune prognostic markers are not completely validated
      in clinical practice in BC patients. Materials and methods: With the aim to
      characterize immune features, several parameters were analyzed in peripheral
      blood at diagnosis of 85 nonmetastatic BC patients between April 2011 and July
      2014. Results: With a median follow-up of 38.6 months, peripheral blood analysis
      of BC patients (stages I, II, and III) showed that total lymphocyte and T
      lymphocyte counts were augmented in nonrelapsed patients. Also, a higher
      neutrophil-to-lymphocytes ratio was associated with prolonged disease-free
      survival. Natural killer cell receptor analysis revealed that early activation
      receptor CD69 was associated with a better outcome. Conclusion: This preliminary
      evidence is in accordance with the concept of immune surveillance. We suggest an
      "immune phenotype" that provides relevant prognostic information in early-stage
      BC patients and which could be useful in the decision-making process.

PMID- 29844688
TI  - miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R.
AB  - Background: In recent years, the aberrant expression of miR-598 in tumorigenesis
      has been demonstrated, as well as the fact that the IGF-1R pathway is also
      involved in the development of human gastric cancer (GC). The present study aimed
      to investigate the molecular mechanisms underlying miR-598-regulated IGF-1R
      expression in human GC. Materials and methods: We analyzed the expression of miR
      598 and IGF-1R in GC samples and cells, and evaluated the clinical significance
      of miR-598 and IGF-1R in GC patients. Furthermore, in vitro and in vivo assays
      were used to investigate the molecular mechanisms of miR-598 and IGF-1R. Results:
      miR-598 expression was frequently downregulated in GC tissues and cells, and
      significantly correlated with poor prognosis, vascular invasion, TNM stage, and
      lymph node metastases as well as IGF-1R expression. The overexpression of miR-598
      obviously inhibited cell proliferation, migration, invasion, and induced cell
      cycle arrest in the G1/S phase, and increased the apoptosis of GC cells. The
      overexpression of miR-598 also significantly inhibited ERK1/2 and Akt
      phosphorylation level. In vivo assay validated the inhibitory effect of miR-598
      on tumor growth. Further studies showed that miR-598 inhibited IGF-1R protein
      expression by directly targeting its 3'-UTR. Besides, over-expression of IGF-1R
      reversed the inhibitory effects of miR-598, while suppression of IGF-1R
      expression showed inverse effects. Conclusion: miR-598 suppresses GC cell
      proliferation, migration and invasion by directly targeting IGF-1R expression.
      Thus, miR-598 may be a useful target for GC patients.

PMID- 29844689
TI  - Downregulation of PDIA3 inhibits proliferation and invasion of human acute
      myeloid leukemia cells.
AB  - Introduction: Acute myeloid leukemia (AML) is a common malignancy of the
      hematopoietic system. In bone marrow samples of AML patients, PDIA3 expression
      was higher than that in the samples of healthy controls. We aimed at exploring
      the effect of PDIA3 siRNA on proliferation, apoptosis, migration, and invasion of
      AML HL-60 and HEL cells. Materials and methods: RT-PCR was performed to identify
      PDIA3 expression. Cell proliferation was assessed by MTT. Flow cytometry analysis
      and transwell were used to detect cell apoptosis, migration and invasion. Gene
      set enrich-ment analysis (GSEA) was employed to explore the PDIA 3-associated
      pathways in AML. Western blotting was used for protein expression detection.
      Results: PDIA3 siRNA significantly inhibited the proliferation of AML cells at 24
      and 48 h. PDIA3 siRNA notably enhanced the percentage of apoptotic cells. The
      migration and invasion abilities of HL-60 and HEL cells in the PDIA3 siRNA group
      were significantly suppressed compared with those in the control and siNC groups.
      GSEA of the Cancer Genome Atlas dataset showed that Kyoto Encyclopedia of Genes
      and Genomes oxidative phosphorylation and amino sugar and nucleotide sugar
      metabolism pathways could be correlated with PDIA3 expression; this was further
      confirmed in AML cells by Western blotting. MAPK signaling was also blocked by
      PDIA3 siRNA. Conclusion: PDIA3 siRNA effectively enhanced apoptosis, and
      suppressed proliferation, invasion, and migration of AML cells by regulating
      oxidative phosphorylation and amino sugar and nucleotide sugar metabolism
      pathways, and MAPK signaling, which can provide novel therapeutic targets for
      AML.

PMID- 29844690
TI  - Plasma-activated water: a new and effective alternative for duodenoscope
      reprocessing.
AB  - Introduction: Duodenoscopes have been widely used for both diagnostic and
      therapeutic endoscopic retrograde cholangiopancreatography procedures. Numerous
      outbreaks of duodenoscope-associated infections involving multidrug-resistant
      bacteria have recently been reported. Plasma activated water (PAW) has been
      widely considered an effective agent for surface decontamination and is
      increasingly used for disinfection of medical equipment. The aim of this study
      was to evaluate whether the duodenoscopes currently on market are suited for the
      repeated use of PAW and to test the efficacy of PAW for their disinfection.
      Materials and methods: In order to evaluate the disinfection efficacy and the
      required time of contact, the duodenoscope samples were contaminated by immersing
      them in fasted-state simulated intestinal fluid containing Escherichia coli,
      Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, prior
      to PAW exposure. In order to test the duodenoscope polymer compatibility with
      PAW, a challenge test was conducted by immersing the samples in PAW for 30
      minutes daily for 45 consecutive days. Results: Significant reductions in
      bacterial populations were achieved after 30 minutes of PAW treatment, indicating
      a high-level disinfection. Atomic force microscopy and scanning electron
      microscopy were used to demonstrate that repeated PAW treatment of duodenoscope
      coating polymer samples did not result in significant differences in
      morphological surface between the treated and untreated samples. Energy
      dispersive X-ray spectroscopy analysis also showed no significant differences
      between the elemental composition of the duodenoscope coating polymer samples
      before and after repeated PAW treatment. Conclusion: Considering these
      preliminary results, PAW could be considered as a new alternative for
      duodenoscope reprocessing.

PMID- 29844691
TI  - Molecular characterization of carbapenem-resistant Gram-negative bacilli clinical
      isolates in Algeria.
AB  - Objectives: The aims of this study were to investigate the occurrence of
      carbapenem-resistant Gram-negative bacilli (GNB) isolated from inpatients and
      outpatients in Algeria between July and September 2015, and to screen their
      resistance mechanisms and genetic relatedness. Materials and methods: A total of
      68 non-redundant isolates were identified using matrix-assisted laser
      desorption/ionization time-of-flight (MALDI-TOF) antibiotic susceptibility
      testing was performed using disk diffusion and Etest methods. Carbapenemase
      activity was carried out using modified Carba NP test, EDTA assay, and the
      modified Hodge test. Molecular characterization of carbapenemases and extended
      spectrum beta-lactamase (ESBL) genes were detected by standard PCR and
      sequencing. Genotyping of carbapenem-resistant isolates was performed by
      multilocus sequence typing (MLST) analysis. Results: Of the 68 GNB isolates, 13
      (19%) showed reduced susceptibility to carbapenems, including, four Klebsiella
      pneumoniae, one Escherichia coli, six Acinetobacter baumannii, and two
      Pseudomonas aeruginosa. blaOXA-48 gene was detected in the five
      Enterobacteriaceae isolates, and blaOXA-23 was identified in all A. baumannii
      isolates. OprD mutations were revealed in the two P. aeruginosa isolates. A total
      of 11 out of the 13 carbapenem-resistant GNB were detected in inpatients, and the
      two remaining strains were isolated from outpatients. Molecular typing showed the
      presence of four sequence types (STs) among the OXA-48-producing K. pneumoniae
      isolates: ST101, ST147, ST163, and ST2017. ST533 was identified for the OXA-48
      producing E. coli isolate. All of the A. baumannii and P. aeruginosa were
      assigned to the international clonal lineages ST2 and ST654, respectively.
      Conclusion: This study reports the first detection of the epidemic multidrug
      resistant lineage, K. pneumoniae ST147 coproduced blaOXA-48 and ESBL genes in
      Algeria and represents the first description of OXA-48-producing E. coli ST533
      and K. pneumoniae ST163 and ST2017. In addition, this study describes for the
      first time the emergence of OXA-48-producing E. coli and K. pneumoniae in the
      community in Algeria, leading to major problems for managing microbial
      infections.

PMID- 29844692
TI  - Severity of primary open-angle glaucoma in patients with hypertension and
      diabetes.
AB  - Background: Primary open-angle glaucoma (POAG) is a progressive optic neuropathy
      with numerous risk factors. Its severity with associated risk factors remains a
      widely debated topic. Aim: To evaluate the severity of POAG in patients with
      hypertension (HTN) and diabetes or both. Patients and methods: This hospital
      based, cross-sectional descriptive study was conducted for a period of 18 months
      from January 2016 to June 2017. Diagnosed cases of POAG were evaluated for
      severity with associated risk factors. Results: A total of 221 patients were
      enrolled in the study. The mean age of the patients was 54.4 (SD +/- 15.9) years
      with a male to female ratio of 0.93:1. Of the 221 patients, 68 (31%) had a family
      history of POAG. Mean intraocular pressure was 15.8+/-4.87 mmHg, and mean central
      corneal thickness was 535.4+/-34.9 MUm. A total of 81 (36%) patients had HTN, 21
      (9.50%) had diabetes mellitus (DM), and 15 (6.80%) had both HTN and DM. Analysis
      using SPSS version 20 was done. The severity of POAG was found to be
      significantly higher in patients with HTN, DM, or both when evaluated on the
      basis of anatomical and functional loss. Conclusion: POAG patients with HTN, DM,
      or both were found to have more severe POAG. Patients with these risk factors
      could represent "high-risk patients" with POAG. Patients with HTN and DM, or both
      may require evaluations on a more frequent basis to access the
      progression/severity of POAG.

PMID- 29844693
TI  - Evaluating the cost-effectiveness of insulin detemir versus neutral protamine
      Hagedorn insulin in patients with type 1 or type 2 diabetes in the UK using a
      short-term modeling approach.
AB  - Background: To estimate the short-term cost-effectiveness of insulin detemir
      (IDet) versus neutral protamine Hagedorn (NPH) insulin based on the incidence of
      non-severe hypoglycemia and changes in body weight in subjects with type 1
      diabetes (T1D) or type 2 diabetes (T2D) in the UK. Methods: A model was developed
      to evaluate cost-effectiveness based on non-severe hypoglycemia, body mass index,
      and pharmacy costs over 1 year. Published rates of non-severe hypoglycemia were
      employed in the T1D and T2D analyses, while reduced weight gain with IDet was
      modeled in the T2D analysis only. Effectiveness was calculated in terms of
      quality-adjusted life expectancy using published utility scores. Pharmacy costs
      were captured using published prices and defined daily doses. Costs were
      expressed in 2016 pounds sterling (GBP). Sensitivity analyses were performed
      (including probabilistic sensitivity analysis). Results: In T1D, IDet was
      associated with fewer non-severe hypoglycemic events than NPH insulin (126.7
      versus 150.8 events per person-year), leading to an improvement of 0.099 quality
      adjusted life years (QALYs). Costs with IDet were GBP 60 higher, yielding an
      incremental cost-effectiveness ratio (ICER) of GBP 610 per QALY gained. In T2D,
      mean non-severe hypoglycemic event rates and body weight were lower with IDet
      than NPH insulin, leading to a total incremental utility of 0.120, accompanied by
      an annual cost increase of GBP 171, yielding an ICER of GBP 1,422 per QALY gained
      for IDet versus NPH insulin. Conclusion: Short-term health economic evaluation
      showed IDet to be a cost-effective alternative to NPH insulin in the UK due to
      lower rates of non-severe hypoglycemia (T1D and T2D) and reduced weight gain (T2D
      only).

PMID- 29844694
TI  - A review of vagus nerve stimulation as a therapeutic intervention.
AB  - In this review, we provide an overview of the US Food and Drug Administration
      (FDA)-approved clinical uses of vagus nerve stimulation (VNS) as well as
      information about the ongoing studies and preclinical research to expand the use
      of VNS to additional applications. VNS is currently FDA approved for therapeutic
      use in patients aged >12 years with drug-resistant epilepsy and depression.
      Recent studies of VNS in in vivo systems have shown that it has anti-inflammatory
      properties which has led to more preclinical research aimed at expanding VNS
      treatment across a wider range of inflammatory disorders. Although the signaling
      pathway and mechanism by which VNS affects inflammation remain unknown, VNS has
      shown promising results in treating chronic inflammatory disorders such as
      sepsis, lung injury, rheumatoid arthritis (RA), and diabetes. It is also being
      used to control pain in fibromyalgia and migraines. This new preclinical research
      shows that VNS bears the promise of being applied to a wider range of therapeutic
      applications.

PMID- 29844695
TI  - Role of biologics and biosimilars in inflammatory bowel disease: current trends
      and future perspectives.
AB  - Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory disease of
      the gastrointestinal system. The spectrum is of predominantly two types, namely,
      ulcerative colitis and Crohn's disease. The incidence of IBD has been increasing
      steadily since 1990, and so the number of agents used in their treatment.
      Biologics that are derived partly or completely from living biological sources
      such as animals and humans have become widely available, which provide
      therapeutic benefits to the IBD patients. Currently, monoclonal antibodies
      against tumor necrosis factor-alpha (infliximab, adalimumab, certolizumab, and
      golimumab), integrins (vedolizumab and natalizumab), and interleukin (IL)-12 and
      IL-23 antagonists (ustekinumab) are approved for use in IBD. Biosimilars of
      infliximab and adalimumab are also available for the treatment of IBD. This
      review summarizes the clinical pharmacology, studies leading to their approval,
      overall indications and their use in IBD, usage in pregnancy and lactation, and
      the adverse effects of these agents. This review also summarizes the recent
      advances and future perspectives specific to biologics and biosimilars in IBD.

PMID- 29844696
TI  - Electroacupuncture therapy in inflammation regulation: current perspectives.
AB  - Although acupuncture therapy is increasingly used to treat diverse symptoms and
      disorders in humans, its underlying mechanism is not known well. Only recently
      have experimental studies begun to provide insights into how acupuncture
      stimulation generates and relates to pathophysiological responsiveness.
      Acupuncture intervention is frequently used to control pathologic symptoms in
      several visceral organs, and a growing number of studies using experimental
      animal models suggest that acupuncture stimulation may be involved in inducing
      anti-inflammatory responses. The vagus nerve, a principal parasympathetic nerve
      connecting neurons in the central nervous system to cardiovascular systems and a
      majority of visceral organs, is known to modulate neuroimmune communication and
      anti-inflammatory responses in target organs. Here, we review a broad range of
      experimental studies demonstrating anti-inflammatory effects of
      electroacupuncture in pathologic animal models of cardiovascular and visceral
      organs and also ischemic brains. Then, we provide recent progress on the role of
      autonomic nerve activity in anti-inflammation mediated by electroacupuncture. We
      also discuss a perspective on the role of sensory signals generated by
      acupuncture stimulation, which may induce a neural code unique to acupuncture in
      the central nervous system.

PMID- 29844697
TI  - Emerging biomarkers in the diagnosis of prostate cancer.
AB  - Prostate cancer (PCa) is the second most common cancer in men worldwide. A large
      proportion of PCa are latent, never destined to progress or affect the patients'
      life. It is of utmost importance to identify which PCa are destined to progress
      and which would benefit from an early radical treatment. Prostate-specific
      antigen (PSA) remains the most used test to detect PCa. Its limited specificity
      and an elevated rate of overdiagnosis are the main problems associated with PSA
      testing. New PCa biomarkers have been proposed to improve the accuracy of PSA in
      the management of early PCa. Commercially available biomarkers such as PCA3
      score, Prostate Health Index (PHI), and the four-kallikrein panel are used with
      the purpose of reducing the number of unnecessary biopsies and providing
      information related to the aggressiveness of the tumor. The relationship with PCa
      aggressiveness seems to be confirmed by PHI and the four-kallikrein panel, but
      not by the PCA3 score. In this review, we also summarize new promising
      biomarkers, such as PSA glycoforms, TMPRSS2:ERG fusion gene, microRNAs,
      circulating tumor cells, androgen receptor variants, and PTEN gene. All these
      emerging biomarkers could change the management of early PCa, offering more
      accurate results than PSA. Nonetheless, large prospective studies comparing these
      new biomarkers among them are required to know their real value in PCa detection
      and prognosis.

PMID- 29844698
TI  - Exploring factors that might influence primary-care provider discussion of and
      recommendation for prostate and colon cancer screening.
AB  - Background: Primary-care providers may contribute to the use of low-value cancer
      screening. Objective: We sought to examine circumstances under which primary-care
      providers would discuss and recommend two types of cancer screening services
      across a spectrum of net benefit and other factors known to influence screening.
      Patients and methods: This was a cross sectional survey of 126 primary-care
      providers in 24 primary-care clinics in the US. Participants completed surveys
      with two hypothetical screening scenarios for prostate or colorectal cancer
      (CRC). Patients in the scenarios varied by age and screening-request status. For
      each scenario, providers indicated whether they would discuss and recommend
      screening. Providers also reported on their screening attitudes and the influence
      of other factors known to affect screening (short patient visits, worry about
      lawsuits, clinical reminders/performance measures, and screening guidelines). We
      examined associations between providers' attitudes and their screening
      recommendations for hypothetical 90-year-olds (the lowest-value screening).
      Results: Providers reported they would discuss cancer screening more often than
      they would recommend it (P<0.001). More providers would discuss and recommend
      screening for CRC than prostate cancer (P<0.001), for younger than older patients
      (P<0.001), and when the patient requested it than when not (P<0.001). For a 90
      year-old patient, every point increase in cancer-specific screening attitude
      increased the likelihood of a screening recommendation (30% for prostate cancer
      and 30% for CRC). Discussion: While most providers' reported practice patterns
      aligned with net benefit, some providers would discuss and recommend low-value
      cancer screening, particularly when faced with a patient request. Conclusion:
      More work appears to be needed to help providers to discuss and recommend
      screening that aligns with value.

PMID- 29844699
TI  - Ethical decision making in pain management: a conceptual framework.
AB  - Introduction: The practice and study of pain management pose myriad ethical
      challenges. There is a consensual opinion that adequate management of pain is a
      medical obligation rooted in classical Greek practice. However, there is evidence
      that patients often suffer from uncontrolled and unnecessary pain. This is
      inconsistent with the leges artis, and its practical implications merit a
      bioethical analysis. Several factors have been identified as causes of
      uncontrolled and unnecessary pain, which deprive patients from receiving
      appropriate treatments that theoretically they have the right to access.
      Important factors include (with considerable regional, financial, and cultural
      differences) the following: 1) failure to identify pain as a priority in patient
      care; 2) failure to establish an adequate physician-patient relationship; 3)
      insufficient knowledge regarding adequate prescription of analgesics; 4)
      conflicting notions associated with drug-induced risk of tolerance and fear of
      addiction; 5) concerns regarding "last-ditch" treatments of severe pain; and 6)
      failure to be accountable and equitable. Objective: The aim of this article was
      to establish that bioethics can serve as a framework for addressing these
      challenging issues and, from theoretical to practical approaches, bioethical
      reflection can contextualize the problem of unrelieved pain. Methods: This
      article is organized into three parts. First, we illustrate that pain management
      and its undertreatment are indeed ethical issues. The second part describes
      possible ethical frameworks that can be combined and integrated to better define
      the ethical issues in pain management. Finally, we discuss possible directions
      forward to improve ethical decision making in pain management. Discussion: We
      argue that 1) the treatment of pain is an ethical obligation, 2) health science
      schools, especially medical training institutions, have the duty to teach pain
      management in a comprehensive fashion, and 3) regulatory measures, which prevent
      patients from access to opioid treatment as indicated in their cases, are
      unethical and should be reconsidered. Conclusion: Developing an ethical framework
      for pain management will result in enhanced quality of care, linking the
      epistemic domains of pain management to their anthropological foundations,
      thereby making them ethically sound.

PMID- 29844700
TI  - Diagnostic accuracy of droplet digital PCR for detection of EGFR T790M mutation
      in circulating tumor DNA.
AB  - Objectives: Although different methods have been established to detect epidermal
      growth factor receptor (EGFR) T790M mutation in circulating tumor DNA (ctDNA), a
      wide range of diagnostic accuracy values were reported in previous studies. The
      aim of this meta-analysis was to provide pooled diagnostic accuracy measures for
      droplet digital PCR (ddPCR) in the diagnosis of EGFR T790M mutation based on
      ctDNA. Materials and methods: A systematic review and meta-analysis were carried
      out based on resources from Pubmed, Web of Science, Embase and Cochrane Library
      up to October 11, 2017. Data were extracted to assess the pooled sensitivity,
      specificity, positive likelihood ratio, negative likelihood ratio (NLR),
      diagnostic OR (DOR), and areas under the summary receiver-operating
      characteristic curve (SROC). Results: Eleven of 311 studies identified have met
      the including criteria. The sensitivity and specificity of ddPCR for the
      detection of T790M mutation in ctDNA ranged from 0.0% to 100.0% and 63.2% to
      100.0%, respectively. For the pooled analysis, ddPCR had a performance of 70.1%
      (95% CI, 62.7%-76.7%) sensitivity, 86.9 % (95% CI, 80.6%-91.7%) specificity, 3.67
      (95% CI, 2.33-5.79) PLR, 0.41 (95% CI, 0.32-0.55) NLR, and 10.83 (95% CI, 5.86
      20.03) DOR, with the area under the SROC curve being 0.82. Conclusion: The ddPCR
      harbored a good performance for detection of EGFR T790M mutation in ctDNA.

PMID- 29844701
TI  - Role of Lactobacillus in cervical cancer.
AB  - Cervical cancer is a common malignant cancer among women worldwide. Changes in
      the vaginal microecological environment lead to multiple gynecological diseases,
      including cervical cancer. Recent research has shown that Lactobacillus may play
      an important role in the occurrence and development of cervical cancer. This
      review explores the role of Lactobacillus in cervical cancer. A total of 29
      articles were included after identification and screening. The pertinent
      literature on Lactobacillus in cervical cancer from two perspectives, including
      clinical studies and experimental studies, was analyzed. An association network
      for the mechanism by which Lactobacillus induces cervical cancer was constructed.
      In addition, we provide direction and insight for further research on the role of
      Lactobacillus in cervical cancer.

PMID- 29844702
TI  - Dichloroacetate enhances the antitumor efficacy of chemotherapeutic agents via
      inhibiting autophagy in non-small-cell lung cancer.
AB  - Background: Chemotherapy is still the primary adjuvant strategy of cancer
      therapy; however, the emergence of multi-drug resistance has been a cause for
      concern. Autophagy has been demonstrated to have a protective role against
      chemotherapeutic drugs in cancer cells, and autophagy inhibition is generally
      considered to be a promising therapeutic strategy. However, the paucity of
      effective and specific autophagy inhibitors limits its application. Purpose: The
      objective of this study was to explore the effect of DCA, small molecular anti
      tumor agent, on the autophagy regulation and chemosensitization in NSCLC cells.
      Methods: We investigated the autophagy regulation of dichloroacetate (DCA) by
      laser confocal microscopy and western blotting in A549 and H1975 cell lines. The
      MTT assay and flow cytometry was performed for explore the chemosensitization
      effectiveness of DCA. The results were verified with subcutaneous tumor model in
      nude mice and the immunohistochemistry was applied for assessing the level of
      cell apoptosis and autophagy in vivo post treatment. Results: We found that DCA,
      which exhibited antitumor properties in various carcinoma models, induced
      apoptosis of non-small cell lung cancer cells (NSCLC) by inhibiting cancer cell
      autophagy. Furthermore, Perifosine, an AKT inhibitor, can greatly weaken the
      capacity of inducing apoptosis by DCA. The results indicate that the AKT-mTOR
      pathway, a main negative regulator of autophagy, is involved in the DCA-induced
      inhibition of autophagy. Then, we detected the effectiveness of autophagy
      inhibition by DCA. When used in co-treatment with the chemotherapeutic drug
      paclitaxel (PTX), DCA markedly decreased cell autophagy, enhanced apoptosis and
      inhibited proliferation in A549 and H1975 cells. The results of the xenograft
      experiment demonstrate that co-treatment of PTX and DCA can significantly
      decrease cell proliferation in vivo and prolong the survival of mice. Conclusion:
      Our results suggest that DCA can inhibit cell autophagy induced by
      chemotherapeutics, providing a new avenue for cancer chemotherapy sensitization.

PMID- 29844703
TI  - Expression and significance of RRBP1 in esophageal carcinoma.
AB  - Objective: This study was to investigate the expression and clinical significance
      of RRBP1 in esophageal carcinoma. Materials and methods: RRBP1 expression was
      detected in 120 esophageal carcinoma and matched adjacent normal tissues, and the
      relationship of RRBP1 with clinicopathological characteristics and prognosis was
      analyzed. Results: RRBP1 was highly expressed in esophageal carcinoma tissues
      compared with matched adjacent normal tissues (P<0.05). Moreover, RRBP1
      expression was associated with T stage, lymph node metastasis, and TNM stage in
      esophageal carcinoma (P<0.05). Survival analysis revealed that RRBP1, T stage,
      lymph node metastasis, and TNM stage were significantly associated with patients'
      prognosis. Conclusion: RRBP1 is highly expressed in esophageal carcinoma and can
      serve as a potential biomarker to predict patients' prognosis.

PMID- 29844704
TI  - The location, histologic type, and stage of lung cancer are associated with
      bleeding during endobronchial biopsy.
AB  - Background: Several risk factors have been proposed for bleeding during
      bronchoscopy, including immunosuppression, thrombocytopenia, pulmonary arterial
      hypertension, and mechanical ventilation. However, research on bronchoscopic
      biopsy-induced bleeding in the population of lung cancer without these "proposed
      risk factors" remains lacking. Patients and methods: A total of 531 lung cancer
      patients with endobronchial biopsy (EBB) were enrolled in this retrospective
      observational study. Patients were divided into biopsy-induced bleeding group
      (n=162) and non-bleeding group (n=369). Using multiple logistic regression,
      independent risk factors for EBB bleeding were identified. Results: The location,
      histologic type, and stage of lung cancer were independently associated with EBB
      bleeding, as assessed by multiple logistic regression (p<0.05) in patients with
      lung cancer. Moreover, during EBB, the risk of bleeding of endobronchial lesions
      located in the central airways was significantly higher when compared to that in
      peripheral bronchi (odds ratio [OR], 2.211; 95% CI, 1.276-3.830; p=0.005). In
      addition, squamous cell carcinoma and small-cell lung carcinoma were more
      susceptible to bleeding during biopsy when compared with adenocarcinoma (OR,
      3.107, 2.389; 95% CI, 1.832-5.271, 1.271-4.489; p=0.000, p=0.007, respectively).
      Patients with advanced lung cancer were more prone to EBB bleeding compared to
      patients in the early stages of disease (OR, 1.583; 95% CI, 1.065-2.354;
      p=0.023). Conclusion: Lesions located in the central airways, histologic types of
      squamous cell carcinoma and small-cell lung carcinoma, and stages of advanced
      lung cancer were the independent risk factors for hemorrhage in EBB.

PMID- 29844706
TI  - Describing the association between socioeconomic inequalities and cancer
      survival: methodological guidelines and illustration with population-based data.
AB  - Background: Describing the relationship between socioeconomic inequalities and
      cancer survival is important but methodologically challenging. We propose
      guidelines for addressing these challenges and illustrate their implementation on
      French population-based data. Methods: We analyzed 17 cancers. Socioeconomic
      deprivation was measured by an ecological measure, the European Deprivation Index
      (EDI). The Excess Mortality Hazard (EMH), ie, the mortality hazard among cancer
      patients after accounting for other causes of death, was modeled using a flexible
      parametric model, allowing for nonlinear and/or time-dependent association
      between the EDI and the EMH. The model included a cluster-specific random effect
      to deal with the hierarchical structure of the data. Results: We reported the
      conventional age-standardized net survival (ASNS) and described the changes of
      the EMH over the time since diagnosis at different levels of deprivation. We
      illustrated nonlinear and/or time-dependent associations between the EDI and the
      EMH by plotting the excess hazard ratio according to EDI values at different
      times after diagnosis. The median excess hazard ratio quantified the general
      contextual effect. Lip-oral cavity-pharynx cancer in men showed the widest
      deprivation gap, with 5-year ASNS at 41% and 29% for deprivation quintiles 1 and
      5, respectively, and we found a nonlinear association between the EDI and the
      EMH. The EDI accounted for a substantial part of the general contextual effect on
      the EMH. The association between the EDI and the EMH was time dependent in
      stomach and pancreas cancers in men and in cervix cancer. Conclusion: The
      methodological guidelines proved efficient in describing the way socioeconomic
      inequalities influence cancer survival. Their use would allow comparisons between
      different health care systems.

PMID- 29844707
TI  - Response to rapamycin analogs but not PD-1 inhibitors in PTEN-mutated metastatic
      non-small-cell lung cancer with high tumor mutational burden.
AB  - In non-small-cell lung cancer (NSCLC) refractory to standard therapy and which
      lacks well-known oncogenic drivers, genomic profiling can still identify genomic
      alterations that may suggest potential sensitivity to targeted therapy. PTEN
      mutation in NSCLC may be sensitizing to analogs of rapamycin such as everolimus
      or temsirolimus, but more investigation is needed. We report the case of a
      patient with metastatic NSCLC harboring a PTEN mutation as well as high tumor
      mutational burden and PD-L1 positivity with a durable response to temsirolimus,
      but refractory to a checkpoint inhibitor. Even in the event of failure of
      treatment with checkpoint inhibitors in the background of a case with a higher
      tumor mutational burden and PD-L1 positivity, targeting specific genomic
      alterations may still result in patient benefit.

PMID- 29844705
TI  - Severe cutaneous adverse reactions induced by targeted anticancer therapies and
      immunotherapies.
AB  - With the increasing use of targeted anticancer drugs and immunotherapies, there
      have been a substantial number of reports concerning life-threatening severe
      cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS),
      toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic
      symptoms, drug-induced hypersensitivity syndrome, and acute generalized
      exanthematous pustulosis. Although the potential risks and characteristics for
      targeted anticancer agent- and immunotherapy-induced SCAR were not well
      understood, these serious adverse reactions usually result in morbidity and
      sequela. As a treatment guideline for this devastating condition is still
      unavailable, prompt withdrawal of causative drugs is believed to be a priority of
      patient management. In this review, we outline distinct types of SCARs caused by
      targeted anticancer therapies and immunotherapies. Also, we discuss the clinical
      course, latency, concomitant medication, tolerability of rechallenge or
      alternatives, tumor response, and mortality associated with these devastating
      conditions. Imatinib, vemurafenib, and rituximab were the top three offending
      medications that most commonly caused SJS/TEN, while EGFR inhibitors were the
      group of drugs that most frequently induced SJS/TEN. For drug rash with
      eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome and
      acute generalized exanthematous pustulosis, imatinib was also the most common
      offending drug. Additionally, we delineated 10 SCAR cases related to innovative
      immunotherapies, including PD1 and CTLA4 inhibitors. There was a wide range of
      latency periods: 5.5-91 days (median). Only eight of 16 reported patients with
      SCAR showed clinical responses. Targeted anticancer drugs and immunotherapies can
      lead to lethal SCAR (14 deceased patients were identified as suffering from
      SJS/TEN). The mortality rate of TEN was high: up to 52.4%. The information
      compiled herein will serve as a solid foundation to formulate ideas for early
      recognition of SCAR and to discontinue offending drugs for better management.

PMID- 29844708
TI  - Simultaneous Gastric Metastasis From Renal Cell Carcinoma: A Case Report and
      Literature Review.
AB  - While some reports are available regarding metachronous gastric metastasis from
      renal cell carcinoma after treatment, there are few reports of primary lesion
      detection based on the diagnosis of a gastric metastatic lesion. The patient in
      this case was an 80-year-old woman who underwent upper gastrointestinal endoscopy
      after having developed anorexia 2 months earlier. A submucosal tumor with central
      umbilication was found in the gastric greater curvature. Endoscopic
      ultrasonography revealed a solid and hypoechoic mass with hypervascularity on
      color Doppler imaging that proliferated mainly within the submucosal layer. There
      was partial exposure of the tumor on the superficial layer. Biopsy was performed,
      as a neuroendocrine tumor was suspected; however, histopathological findings with
      immunostaining revealed gastric metastasis from clear renal cell carcinoma.
      Subsequently, contrast enhanced computed tomography showed right renal cell
      carcinoma and liver metastasis. Thus, molecularly targeted drug treatment was
      initiated by the Department of Urology. Our findings indicate that a primary
      lesion can be identified and prognosis can be assumed based on biopsy of the
      gastric metastatic lesion. Immunostaining of biopsy samples collected
      endoscopically could help achieve definite diagnosis.

PMID- 29844709
TI  - Post-acute Care for Children and Youth in Texas, 2011-2014.
AB  - Little is known about services provided to children and youth (C/Y) discharged
      from an acute care facility. Recent research has provided a foundation for
      efforts to supplement or complement that early work. This research investigates
      post-acute care (PAC) in Texas. It focuses on what differentiates those
      discharges that receive PAC from those that do not and on what differentiates
      those C/Y who receive PAC in a health care facility from those who receive home
      health services. The results show that only 6.4% of discharges involving C/Y
      receive PAC and that many factors affected the 2 issues under investigation quite
      differently. These results clearly demonstrate the low prevalence of PAC use for
      C/Y and the clear preference of using PAC home health in this population.

PMID- 29844710
TI  - A rare and unusual new bittiine genus with two new species from the South Pacific
      (Cerithiidae, Gastropoda).
AB  - A new genus, Limatiumgen. n., and two new species, L. pagodulasp. n. and L.
      aureumsp. n. are described, found on outer slopes of barrier reefs and fringing
      reefs in the South Pacific. They are rare for cerithiids, which typically occur
      in large populations. The two new species are represented by 108 specimens
      sampled over a period of 30 years, only 16 of which were collected alive. Three
      subadults from the Philippines and Vanuatu likely represent a third species. In
      addition to their rarity, Limatium species are atypical for cerithiids in their
      smooth, polished, honey to golden brown shells with distinctive white fascioles
      extending suture to suture. The radula presents a unique morphology that does not
      readily suggest an affinity to any of the cerithiid subfamilies. Two live
      collected specimens, one of each species and designated as holotypes, were
      preserved in 95% ethanol and sequenced. Bayesian analysis of partial COI and 16S
      rDNA sequences demonstrates a placement in the Bittiinae, further extending our
      morphological concept of the subfamily.

PMID- 29844711
TI  - Revision of genus Pericalus from China, with descriptions of four new species
      (Carabidae, Lebiini, Pericalina).
AB  - Nine taxa of the genus Pericalus Macleay from China are revised, with four new
      species described: Pericalus gibbosussp. n. (type locality: Putao, Myanmar; one
      paratype from Medog, Xizang), Pericalus eleganssp. n. (type locality: Medog,
      Xizang), Pericalus acutidenssp. n. (type locality: Longchuan, Yunnan), and
      Pericalus obscuratussp. n. (type locality: Fanjingshan, Guizhou). Four taxa are
      newly recorded from China: Pericalus ornatus ornatus Schmidt-Gobel (Yunnan,
      Hainan), P. obtusipennis Fedorenko (Yunnan), P. amplus Andrewes (Yunnan), and P.
      dux Andrewes (Yunnan). Pericalus formosanus Dupuis is newly ranked as a
      subspecies of P. ornatus Schmidt-Gobel. An improved key to world species of the
      subgenus Pericalus is provided, along with distribution maps and images of
      habitus and male and female genitalia for all Chinese species.

PMID- 29844712
TI  - A multi-access identification key based on colour patterns in ladybirds
      (Coleoptera, Coccinellidae).
AB  - An identification key based on French ladybird colouration is proposed for the
      tribes Chilocorini, Coccinellini, and Epilachnini. These tribes were chosen based
      on their relatively limited species diversity, as well as their large size and
      high colour diversity, making them easy to observe and collect. The
      identification key runs on Xper3 software, which allows the building of
      structured knowledge bases and online free-access keys. The online interactive
      Xper key is available at http://french-ladybird.identificationkey.fr.

PMID- 29844713
TI  - Revision of the Hawaiian psyllid genus Swezeyana, with descriptions of seven new
      species (Hemiptera, Psylloidea, Triozidae).
AB  - The endemic Hawaiian genus Swezeyana Caldwell, 1940 is highly distinctive due to
      the extremely long genal processes. In addition, some of the immatures are
      ornamented with extraordinary tubercles and tentacles. Two Swezeyana species are
      redescribed, and seven new species are described, bringing the total number of
      species in the genus to nine. All species are hosted by a single, endemic host
      plant, Planchonella sandwicensis (Sapotaceae), which is distributed across all
      major islands in the archipelago. The majority of Swezeyana species are single
      island endemics. A sister taxon pair is found sympatrically on the same
      individual plants on Kauai, and putative sister or at least closely related
      species are also found sympatrically on Oahu and Hawaii, suggesting these taxa
      may have diversified in sympatry. However, there is no observed ecological niche
      partitioning, despite some striking morphological diversity, as all Swezeyana
      species have free-living immatures that are found on the leaf surface, and
      therefore no apparent biological shifts are coincident with occupying the same
      host plant. Two species groups are represented by strikingly different female
      terminalia structure and endoskeletal development, although ovipositor structure
      is very similar between the two groups. Mitochondrial DNA barcodes (COI and cytB)
      are provided for eight of the nine species. A phylogenetic analysis of the
      mitochondrial barcode regions indicates species relationships within Swezeyana
      and provides a comparison of genetic divergence with other Hawaiian endemic
      genera.

PMID- 29844714
TI  - Larva and pupa of Ctesias (s. str.) serra (Fabricius, 1792) with remarks on
      biology and economic importance, and larval comparison of co-occurring genera
      (Coleoptera, Dermestidae).
AB  - Updated descriptions of the last larval instar (based on the larvae and exuviae)
      and first detailed description of the pupa of Ctesias (s. str.) serra (Fabricius,
      1792) (Coleoptera: Dermestidae) are presented. Several morphological characters
      of C. serra larvae are documented: antenna, epipharynx, mandible, maxilla,
      ligula, labial palpi, spicisetae, hastisetae, terga, frons, foreleg, and
      condition of the antecostal suture. The paper is fully illustrated and includes
      some important additions to extend notes for this species available in the
      references. Summarised data about biology, economic importance, and distribution
      of C. serra are also provided. The comparison of larval characteristics for some
      of the genera of Dermestidae co-occurring with Ctesias is presented. A key for
      identification of these genera is also provided.

PMID- 29844715
TI  - Assessment of knowledge, attitude and practice of adverse drug reaction reporting
      among healthcare professionals in secondary and tertiary hospitals in the capital
      of Pakistan.
AB  - Adverse Drug Reactions (ADRs) underreporting is a great challenge to
      pharmacovigilance. Healthcare professionals should consider ADR reporting as
      their professional obligation because the effective system of ADR reporting is
      important to improve patient care and safety. This study was designed to assess
      the knowledge, attitude, practice and factors associated with ADR reporting by
      healthcare professionals (physicians and pharmacists) in secondary and tertiary
      hospitals of Islamabad. A pretested questionnaire comprising of 27 questions
      (knowledge 12, attitude 4, practice 9 and factors influencing ADR reporting 2)
      was administered to 384 physicians and pharmacists in public and private
      hospitals. Respondents were evaluated for their knowledge, attitude and practice
      related to ADR reporting. Additionally, the factors which encourage and
      discourage respondents to report ADRs were also determined. The data was analysed
      by using SPSS statistical software. Among 384 respondents, 367 provided responses
      to questionnaire, giving a response rate of 95.5%. The mean age was 28.3 (SD =
      6.7). Most of the respondents indicated poor ADR reporting knowledge (83.1%). The
      majority of respondents (78.2%) presented a positive attitude towards ADR
      reporting and only a few (12.3%) hospitals have good ADR reporting practice. The
      seriousness of ADR, unusualness of reaction, new drug involvement and confidence
      in the diagnosis of ADR are the factors which encourage respondents to report ADR
      whereas lack of knowledge regarding where and how to report ADR, lack of access
      to ADR reporting form, managing patient is more important than reporting ADR
      legal liability issues were the major factors which discourage respondents to
      report ADR. The study reveals poor knowledge and practice regarding ADR
      reporting. However, most of the respondents have shown a positive attitude
      towards ADR reporting. There is a serious need for educational training as well
      as sincere and sustained efforts should be made by Government and Hospital
      Authorities to ensure proper implementation of ADR reporting system in all of the
      hospitals.

PMID- 29844716
TI  - GC quantitative analysis of benzyl isothiocyanate in Salvadora persica roots
      extract and dental care herbal products.
AB  - An accurate, sensitive, precise and simple method was developed utilizing Gas
      Chromatography for the quantitative analysis of benzyl isothicyanate in Siwak
      extract and dental care herbal products claimed to contain Siwak. Rtx (30.0 m *
      0.25 mm ID, 25 um thickness) column was used and helium as carrier gas at a flow
      rate of 0.74 mL/min. The retention time of standard benzyl isothicyanate was
      13.470 min under the described conditions. Linear regression data analysis
      indicated a good linear relationship between peak height measurement and
      concentration of benzyl isothiocyanate in the range of 10-50 ug/ml (R2 = 0.9971).
      The regression equation was y = 11,471x. The developed GC method was subjected to
      validation requirements set by the ICH for precision, accuracy, and robustness.
      The entitled GC analyses expected to be valuable for the determination of benzyl
      isothiocyanate in Siwak extracts and other formulations containing Siwak extract.
      The amount of benzyl isothiocyanate reflects the efficacy of the products.

PMID- 29844717
TI  - Characterization of forced degradation products of toloxatone by LC-ESI-MS/MS.
AB  - Forced degradation of toloxatone in solutions under basic, acidic, neutral, photo
      UV-VIS, photo UVC and oxidative stress conditions was investigated and structural
      elucidation of its degradation products was performed with the use of UHPLC
      system coupled ESI-Q-TOF mass spectrometer. Eight degradation products were found
      and their masses and formulas were obtained with high accuracy (0.09-3.79 ppm).
      The structure of unknown degradation products were elucidated from MS/MS
      fragmentation spectra of all analyzed compounds. Additionally, whole signals of
      decomposed substances were compared chemometrically. It was found that toloxatone
      is fragile towards basic hydrolysis, oxidative conditions and UVC irradiation.
      Finally, the toxicity of transformation products was computationally evaluated
      and compared in multivariate manner.

PMID- 29844718
TI  - Clinical pharmacy in Kuwait: Services provided, perceptions and barriers.
AB  - Introduction: Pharmacy practice has considerably evolved from a dispensing role
      to a patient-centered profession. Kuwait has minimal clinical pharmacy services
      established in its healthcare settings. Objectives: The objectives of this study
      were to document existing clinical pharmacy services in public hospitals,
      identify barriers to their implementation and assess perceptions regarding
      pharmacists providing clinical services. Material & Method: A cross sectional
      study using self-administered questionnaires among a total of 166 pharmacists and
      284 physicians across 6 public hospitals in Kuwait was conducted. Results: Over
      half of pharmacists (54%) provided clinical services, with the most common
      service being education and drug information (86%). Forty percent (40%) of the
      pharmacists reported that clinical services offered were of their own initiative
      but most of them (71%) were not sure whether they would offer additional services
      in the future. The majority of physicians were receptive to an expanded patient
      centered role of the pharmacist (97%), believed pharmacists add to patient
      clinical care (92%) and considered pharmacists members of the healthcare team
      (96%). Major barriers reported by pharmacists to implement clinical pharmacy
      services included lack of policy (49%), time (36%) and clinical skills (28%),
      which is similar to barriers reported by physicians. Conclusion: Although
      clinical pharmacy is in its infancy in Kuwait, it is well perceived and requested
      by physicians. Major barriers must be addressed and in this context, having a
      national framework for pharmacy practice from Ministry of Health, supported by
      cutting edge education and a pro-active professional association would be key
      assets to evolve the practice in Kuwait.

PMID- 29844719
TI  - A qualitative study exploring patients' experiences regarding insulin pump use.
AB  - Background: Diabetes is a threat to peoples' lives around the world, particularly
      in the Middle East. Medicine misuse and poor glycaemic control are prevalent
      among patients with type 2 diabetes, especially insulin-dependent patients
      (Alsairafi et al., 2016). With advances in medical technology, insulin pumps
      became a treatment option for patients with type 1 diabetes and those with
      insulin-dependent type 2 diabetes. However, use of these devices is still lacking
      in Kuwait, particularly in patients with type 2 diabetes. Information on how
      patients manage these devices and their efficacy and safety from the perspectives
      of patients is also lacking (Alsaleh et al., 2016). Objective: To examine the
      views and experiences of adults with type 2 diabetes regarding the use of insulin
      pumps compared to their previous insulin delivery methods, in terms of glycaemic
      control, quality of life, preference, convenience and adherence to doses.
      Setting: The main five secondary-care hospitals in Kuwait: Mobarak Al-Kabeer, Al
      Amiri, Al Adan, Al Farwaniya and Al Jahra. Method: All adults with type 2
      diabetes who used an insulin pump were invited to participate. Data were
      collected through semi-structured interviews. Data analysis was performed using
      MAXQDA-11. Results: A total of eight patients were interviewed. Interviews with
      patients revealed that using an insulin pump improved patients' glycaemic control
      and quality of life as a consequence of improved satisfaction and adherence to
      doses. Conclusion: From the perspective of adults with type 2 diabetes, there are
      lots of benefits of using insulin pumps over other insulin delivery methods,
      mainly seen by the improvement of quality of life and patients' adherence to
      doses. Policy-makers and healthcare professionals (HCPs) must be aware of such
      benefits and should support the wider implementation of this technology in the
      country by including patients with type 2 diabetes. Results of this study will
      help to inform healthcare provision and guideline modifications and to provide
      guidance for new patients using this therapy.

PMID- 29844720
TI  - Evaluation of the hepatoprotective effect of combination between hinokiflavone
      and Glycyrrhizin against CCl4 induced toxicity in rats.
AB  - Liver diseases are one of the fatal syndromes due to the vital role of the liver.
      Most of the effective treatment of liver conditions are of natural origin.
      Silymarin (SI) is the standard drug used for treatment of impaired liver
      functions. Two natural compounds possessing promising liver protection and with
      different chemical structures namely; the bioflavonoid hinokiflavone (HF)
      isolated from Junipers phoenicea family Cupressaceae and the sweet saponin
      Glycyrrhizin (GL) present in Glycyrrhiza glabra (liquorice) were selected for the
      current study. Since the two compounds are of different nature, they may act by
      different mechanisms and express synergistic effect. Combination of the two
      compounds using to dose levels were challenged with single doses of HF, GL and SI
      as well. The comparison was monitored via measuring serum biochemical parameters
      including, aspartate aminotransferase (AST), alanine aminotransferase (ALT),
      gamma glutamyltranspeptidase (GGT), alkaline phosphatase (ALP) and total
      bilirubin, tissue parameters such as MDA, NP-SH and TP, histopathological study
      using light and electron microscope. Protective effect on kidney was also
      monitored histopathologically and biochemically through observing the levels of
      LDH, creatinine, creatinine-kinase, urea and uric acid. The combinations of HF
      and GL showed protective effect more than the used single doses of HF and GL
      alone. However, SI was superior to the used combination in the two used doses in
      all the measured parameters. The liver and kidney cells appearance under normal
      and electron microscope showed that SI treated groups showed almost normal cells
      with slight toxic signs. Cells from group treated with the higher doses of the
      combination of HF and GL showed slight signs of intoxication under light and
      electron microscope indicating good level of protection. Although the combination
      of HF and GL expressed good protection in the higher dose, however, the
      combination did not exceed the protective effect of SI.

PMID- 29844721
TI  - Phytochemical contents and biological evaluation of Ruta chalepennsis L. growing
      in Saudi Arabia.
AB  - Phytochemical screening of Ruta chalepensis L. exhibited the presence of
      different chemical groups. The dried aerial parts of the plant was total
      extracted by ethanol and successively using chloroform, ethyl acetate and
      Butanol, out of the successive extracts four compounds namely, scopletin,
      kaempferol, quercetin, quercetin 3-O-alpha-L-rhamno glucopyranosyl (Rutin) were
      isolated and biological evaluations. Total ethanol and successive extracts;
      chloroform, ethyl acetate and Butanol were produced excellent antimicrobial
      activities against gram negative bacteria, gram positive bacteria and fungi.
      Ethyl acetate extract was the best for inhibition of the microorganism's growth.
      All extracts (total ethanol, and successive extracts) showed DPPH radical
      scavenging activity in a concentration-dependent manner. The best antioxidant
      activity was obtained by ethyl acetate & n-butanol extract (94.28%, IC50 = 56.6
      ug/ml). Also All extracts (total ethanol, and successive extracts) showed
      anticoagulant activity at higher concentration with prolonged clotting time 6:30
      and 4:30 s at 10 mg/ml concentrations, respectively.

PMID- 29844722
TI  - Pharmaceutical significance of Leuconostoc mesenteroides KS-TN11 isolated from
      Nile Tilapia, Oreochromis niloticus.
AB  - Aquatic animals are known for their myriad of beneficial bacteria with diverse
      biologically active compounds. The current study was aimed to isolate and
      characterize potentially beneficial lactic acid bacteria from Nile Tilapia and
      evaluate their pharmaceutical applications. The fish samples were dissected and
      stomach, intestine, and gills were collected and serially diluted for the
      isolation of lactic acid bacteria (LAB) on BCP agar media. Identification of
      isolate was carried by biochemical and molecular characterization using API kit
      and 16S rRNA gene sequencing analysis, respectively. Further, KS-TN11 was
      assessed for alpha-glucosidase inhibitory potential using the chromogenic method.
      A lactic acid bacterium KS-TN11 was isolated from the stomach of Nile Tilapia and
      identified as Leuconostoc mesenteroides. Effect of KS-TN11 on lipid accumulation
      in adipocytes was done by using Oil Red O staining. The isolate showed strong
      antibacterial activity against a number of pathogenic bacteria in vitro. In
      addition, L. mesenteroides KS-TN11 KS-TN11 (50 mg/ml and 100 mg/ml) tends to
      inhibit adipogenesis in 3T3-L1 adipocytes and thus may have possible anti-obesity
      effects. Moreover, L. mesenteroides KS-TN11 exhibited substantial alpha
      glucosidase inhibitory activities by 41.33% at 50 mg/ml and 64% at 100 mg/ml,
      respectively. The bacterium showed potent antibacterial activity against a number
      of pathogenic bacteria; in addition to alpha-glucosidase activity, and inhibition
      of lipid accumulation in 3T3-L1 cell line. These results reinforce KS-TN11 as a
      novel bacterium with an impending pharmaceutical application.

PMID- 29844723
TI  - Aggregation and conformational stability evaluation of myoglobin in the presence
      of ionic surfactant.
AB  - Sodium lauroyl sarcosinate (SLS) is frequently used for the solubilization of
      inclusion bodies in vitro due to its structural similarity to lipid plasma
      membrane. There are many factors that could influence protein aggregation
      propensity, including overall protein surface charge and hydrophobicity. Here,
      the aggregation pathway of myoglobin protein was studied under different
      conditions (pH 3.5 and 7.4) in the presence of varying concentrations of SLS to
      evaluate the underlying forces dictating protein aggregation. Data obtained from
      Rayleigh light scattering, ThT binding assay, and far-UV CD indicated that SLS
      have different effects on the protein depending on its concentration and
      environmental conditions. In the presence of low concentrations of SLS (0.05-0.1
      mM), no aggregation was detected at both pH conditions tested. Whereas, as we
      reach higher SLS concentrations (0.5-10.0 mM), myoglobin started forming larger
      sized aggregates at pH 3.5 and not pH 7.4. These results suggest that
      electrostatics interactions as well as hydrophobic forces play an important role
      in SLS-induced myoglobin aggregation.

PMID- 29844724
TI  - Revisiting the systemic lipopolysaccharide mediated neuroinflammation: Appraising
      the effect of l-cysteine mediated hydrogen sulphide on it.
AB  - The present research was ventured to examine the effect of l-cysteine on neuro
      inflammation persuaded by peripheral lipopolysaccharides (LPS, 125 MUg/kg, i.p.)
      administration. No behavioral, biochemical, and inflammatory abnormality was
      perceived in the brain tissues of experimental animals after LPS administration.
      l-cysteine precipitated marginal symptoms of toxicity in the brain tissue.
      Similar pattern of wholesome effect of LPS were perceived when evaluated through
      the brain tissue fatty acid profile, histopathologically and NF-KBP65 protein
      expression. LPS was unsuccessful to alter the levels of hydrogen sulphide (H2S),
      cyclooxygenase (COX) and lipoxygenase (LOX) enzyme in brain tissue. LPS afforded
      significant peripheral toxicity, when figured out through inflammatory markers
      (COX, LOX), gaseous signaling molecules nitric oxide (NO), H2S, liver toxicity
      (SGOT, SGPT), and inflammatory transcription factor (NF-KBP65) and l-cysteine
      also provided a momentous protection against the same as well. The study
      inculcated two major finding, firstly LPS (i.p.) cannot impart inflammatory
      changes to brain and secondly, l-cysteine can afford peripheral protection
      against deleterious effect of LPS (i.p.).

PMID- 29844725
TI  - Self-emulsifying drug delivery system improves preventive effect of curcuminoids
      on chronic heart failure in rats.
AB  - Several studies have reported the preventive or therapeutic effect of
      curcuminoids on chronic heart failure (CHF), but their application was limited
      due to low solubility and bioavailability. Our previous study indicates that self
      emulsifying drug delivery system (SEDDS) improves the solubility and
      bioavailability of curcuminoids. Thus, the aim of this work was to investigate
      whether SEDDS could improve preventive effect of curcuminoids on CHF in rats. CHF
      model was were established by coronary artery ligation. Ninety rats were randomly
      and averagely divided into sham, model, low- or high-dose suspension or SEDDS of
      curcuminoids (66.68 or 266.68 mg/kg) groups. Hemodynamic indices were recorded by
      multipurpose polygraph. Serum oxidative indices, B-type natriuretic peptide (BNP)
      and heart weight index were determined by kits and electronic balance. Myocardial
      infarct area, ventricular dilatation degree and collagen volume fraction of
      myocardial interstitium were analyzed by Masson staining, picric acid and sirius
      red staining, light microscopy and image analysis system. Myocardial
      histopathology was observed by hematoxylin and eosin staining, Masson staining
      and light microscopy. Reduction of ventricular pump function, increase of BNP
      level and heart weight index, myocardial lipid peroxidation damage, myocardial
      infarction, myocardial fibrosis, and cardiac enlargement were detected or
      observed in model group relative to those in sham group. After treatment with
      suspension or SEDDS of curcuminoids, the above-mentioned pathological changes
      were obviously reversed relative to those in model group. Meanwhile, the
      ameliorative effect of SEDDS of curcuminoids was markedly better than that of
      suspension of curcuminoids. This work provides a valuable reference from
      pharmacodynamics for development of curcuminoids pharmaceutics.

PMID- 29844726
TI  - In - Vitro activity of Desmostachya bipinnata (L.) Stapf successive extracts
      against Helicobacter pylori clinical isolates.
AB  - Helicobacter pylori are well acknowledged as a major cause of gastrointestinal
      ailments and gastric cancers. Therefore, the present study aimed to investigate
      the potential in vitro activity of Desmostachya bipinnata against H. pylori,
      focusing on the determination of the most active extract responsible for the anti
      helicobacter activity to produce new active drug from natural source.
      Desmostachya bipinnata total alcohol and successive extracts were in vitro tested
      against H. pylori. All extracts showed promising anti Helicobacter pylori
      activities. The most effective extract was diethyl ether extract, it showed 75%
      growth inhibition of the clinical Isolates bacterial Helicobacter pylori, in
      addition it showed high count reduction on the selected organisms in the
      different concentrations used (2xMIC, MIC & 1/2 MIC) compared with the untreated
      controls as well as the other extracts (chloroform, ethyl acetate and n-butanol).
      The oral median lethal dose (LD50) of the alcohol extract of the plant by doses
      up to 5000 mg/kg didn't showed any mortality or morbidity, in addition no side
      effects were recorded on both liver and kidney functions this means that the
      extract was safe for use.

PMID- 29844727
TI  - The possible mechanisms of protocatechuic acid-induced central analgesia.
AB  - It is aimed to investigate the central antinociceptive effect of protocatechuic
      acid and the involvement of stimulation of opioidergic, serotonin 5-HT2A/2C,
      alpha2-adrenergic and muscarinic receptors in protocatechuic acid-induced central
      analgesia in mice. Time-dependent antinociceptive effects of protocatechuic acid
      at the oral doses of 75, 150 and 300 mg/kg were tested in hot-plate (integrated
      supraspinal response) and tail-immersion (spinal reflex) tests in mice. To
      investigate the mechanisms of action; the mice administered 300 mg/kg
      protocatechuic acid (p.o.) were pre-treated with non-specific opioid antagonist
      naloxone (5 mg/kg, i.p.), serotonin 5-HT2A/2C receptor antagonist ketanserin (1
      mg/kg, i.p.), alpha2-adrenoceptor antagonist yohimbine (1 mg/kg, i.p.) and non
      specific muscarinic antagonist atropine (5 mg/kg, i.p.), respectively. The
      antinociceptive effect of protocatechuic acid was observed at the doses of 75,
      150 and 300 mg/kg in tail-immersion test, at the doses of 150 and 300 mg/kg in
      hot-plate test at different time interval. The enhancement in the latency of
      protocatechuic acid-induced response to thermal stimuli was antagonized by
      yohimbine, naloxone and atropine in tail-immersion test, while it was antagonized
      only by yohimbine and naloxone pretreatments in hot-plate test. These results
      indicated that protocatechuic acid has the central antinociceptive action that is
      probably organized by spinal mediated cholinergic and opiodiergic, also spinal
      and supraspinal mediated noradrenergic modulation. However, further studies are
      required to understand how protocatechuic acid organizes the interactions of
      these modulatory systems. As a whole, these findings reinforce that
      protocatechuic acid is a potential agent that might be used for pain relief.
      Additionally, the clarification of the effect and mechanisms of action of
      protocatechuic acid will contribute to new therapeutic approaches and provide
      guidance for new drug development studies.

PMID- 29844728
TI  - Inverse docking based screening and identification of protein targets for
      Cassiarin alkaloids against Plasmodium falciparum.
AB  - Various reports have shown Cassiarin alkaloids, selective in vitro activities
      against various strains of Plasmodium falciparum with low cytotoxicity, which
      indicates their possible candidature as antimalarial drug. However, poor
      recognition of their protein targets and molecular binding behaviour, certainly
      limits their exploration as antimalarial drug candidature. To address this, we
      utilises inverse screening, based on three different docking methodologies in
      order to find their most putative protein targets. In our study, we screened 1047
      protein structures from protein data bank, which belongs to 147 different
      proteins. Our investigation identified 16 protein targets for Cassiarins. In few
      cases of identified protein targets, the binding site was poorly studied, which
      encouraged us to perform comparative sequence and structural studies with their
      homologous proteins, like as in case of Kelch motif associated protein, Armadillo
      repeats only protein and Methionine aminopeptidase 1b. In our study, we also
      found Tryptophanyl-tRNA synthetase and 1-Deoxy-D-Xylose-5-phosphate
      reductoisomerase proteins are the most common targets for Cassiarins.

PMID- 29844729
TI  - Synthesis and antibacterial activity of new (2,4-dioxothiazolidin-5
      yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2
      thiohydantoin moieties.
AB  - A series of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with
      thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moiety (28-65) were
      synthesized by the reaction of (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid
      chlorides with 5-(hydroxybenzylidene) thiazolidine-2,4-dione, rhodanine and 2
      thiohydantoin derivatives. Obtained compounds (28-65) were tested on reference
      strains of Gram-positive bacteria and ones of the Gram-negative bacteria. The
      antibacterial activity of target compounds was determined by broth microdilution
      method. These derivatives showed antibacterial activity generally against Gram
      positive bacterial strains. Most active compounds possess MIC = 3.91 mg/L. Our
      results suggest that presence of electron-withdrawing substituent at phenyl ring
      is favorable while geometry of molecule does not play important role in
      antibacterial response. It was confirmed the lack of direct influence of
      substitution pattern at phenyl ring on antibacterial activity of closely related
      compounds of series 1-3. The antibacterial activity of some compounds was similar
      or higher than the activity of commonly used reference drugs such as oxacillin
      and cefuroxime.

PMID- 29844730
TI  - Comparison between the dissolution profiles of nine meloxicam tablet brands
      commercially available in Buenos Aires, Argentina.
AB  - In this work, the dissolution profiles of nine meloxicam tablet brands marketed
      in Argentina have been evaluated. As meloxicam is a Class 2 Biopharmaceutical
      Classification System (BSC) drug, interchangeability between commercial products
      must be demonstrated through in vivo bioequivalence studies. However, in our
      country, such studies remain to be performed. Dissolution studies have been
      performed according to USP 38 and evaluated by fitting experimental data to the
      zero and first-order, the Hixson-Crowell, the Higuchi, and the Weibull model
      dependent methods. To test the pertinence of these release models, the Akaike
      Information Criteria (AIC) were used. All brands satisfied the dissolution
      profiles (phosphate buffer, pH 7.5) established in the USP. The comparison
      between the dissolution profiles was carried out by model-dependent and model
      independent methods. The Weibull model provided the best kinetic curve
      adjustment. Brands I, II, IV and VI had the best fitting, with the maximum
      determination coefficient and the smallest AIC values. Model-independent methods
      included ratio test and the fit factors. The Dissolution Efficiency (DE) and Mean
      Dissolution Time (MDT) were analysed with ANOVA and the DGC method. In both
      cases, brand I did not show similarity with the rest of the brands. Using fit
      factors, only brands I, II and V were similar to each other. Significant
      differences were found among the in vitro dissolution profiles of meloxicam
      tablets belonging to the nine brands. As meloxicam is a class 2 BCS drug,
      interchangeability between commercial products must be demonstrated through in
      vivo bioequivalence studies. However, in Argentina, such studies remain to be
      performed. Our results demonstrate that caution must be exercised as regards
      interchangeability of generic products.

PMID- 29844731
TI  - Newly developed controlled release subcutaneous formulation for tramadol
      hydrochloride.
AB  - This study presents a drug delivery system of poly (E-caprolactone) (PCL) ribbons
      to optimize the pharmaceutical action of tramadol for the first time according to
      our knowledge. PCL ribbons were fabricated and loaded with tramadol HCl. Ribbons
      were prepared by slip casting technique and coated with dipping technique with
      beta-cyclodextrin. The chemical integrity and surface morphology of the ribbons
      were confirmed using FTIR and SEM coupled with EDX. In addition, thermodynamic
      behavior of the fabricated ribbons was investigated using DSC/TGA. Tramadol
      loading into PCL ribbons, biodegradation of ribbons and tramadol release kinetics
      were studied in PBS.The results revealed that the formulated composition did not
      affect the chemical integrity of the drug. Furthermore, SEM/EDX confirmed the
      inclusion of tramadol into the PCL matrix in homogenous distribution pattern
      without any observation of porous structure. The particle size of loaded tramadol
      was found to be in the range of (2-4 nm). The formulated composition did not
      affect the chemical integrity of the drug and should be further investigated for
      bioavailability. Tramadol exhibited controlled release behavior from PCL ribbons
      up to 45 days governed mainly by diffusion mechanism. The fabricated ribbons have
      a great potentiality to be implemented in the long term subcutaneous delivery of
      tramadol.

PMID- 29844732
TI  - PROSPECTIVE STUDY OF ASPIRIN FOR THROMBOEMBOLISM PROPHYLAXIS IN TOTAL HIP
      ARTHROPLASTY.
AB  - Objectives: To evaluate the effectiveness of aspirin as prophylaxis for deep
      venous thrombosis (DVT) in patients undergoing total hip arthroplasty (THA), and
      to analyze the incidence of bleeding during the post-operative period. Methods:
      This prospective study carried out in 2017 consisted of 37 patients indicated for
      THA with high risk for DVT. Immediately after the procedure, aspirin, elastic
      compression socks and early deambulation were initiated. Doppler ultrasound was
      performed in the legs 6 days and 6 weeks post-procedure to rule out venous
      thromboembolism. Hematometric variables and clinical criteria were used to detect
      bleeding. Results: The incidence of VTE (venous thromboembolism) 6 days post
      procedure was 21.6%. By 6 weeks post-procedure, it dropped to 8.1%, (p = 0.102).
      Only 2.7% were diagnosed with VTE, 6 days and also 6 weeks post-procedure. Within
      the immediate postoperative period, hemoglobin was lower (p < 0.001), in contrast
      to 6 weeks after surgery, when it returned to baseline levels. Conclusion:
      Aspirin was an effective chemical prophylaxis for venous thromboembolism in high
      risk patients who underwent THA. There was no clinical record of postoperative
      bleeding and hematometric levels suggested that there was no chronic bleeding.
      Level of Evidence II; Prospective study.

PMID- 29844733
TI  - SQUAMOUS CELL CARCINOMA IN THE FOOT: CASE SERIES AND LITERATURE REVIEW.
AB  - Objectives: To report a case series of squamous cell carcinoma (SCC) in the foot,
      describing previous risk factors, surgical treatment, histopathological findings,
      and functional and oncological results. Methods: Nine consecutive patients
      diagnosed with SCC of the foot were treated at a single institution and
      prospectively analyzed for risk factors related to the disease, surgical outcome,
      and histopathological, functional and oncological results. All patients had
      identifiable risk factors for SCC. Results: Definitive treatment consisted of
      partial (6 patients) or total (3 patients) amputation of the foot. The functional
      score was good or excellent in the surviving patients. Early identifiable risk
      factors are present in most patients. Biopsy when this diagnosis is suspected, in
      association with oncological principles, avoids diagnostic and treatment errors.
      Conclusion: Despite delayed diagnosis and surgical treatment with partial and
      total amputations of the foot in our series, we observed good oncological
      outcomes that avoided systemic spread of the disease and achieved expected
      functional results. Level of Evidence V; Case series.

PMID- 29844734
TI  - Texas Heart Institute Medal and the Ray C. Fish Award for Scientific Achievement
      in Cardiovascular Diseases.

PMID- 29844735
TI  - Public Hospitals Matter.

PMID- 29844736
TI  - Kindness Can Move Mountains.

PMID- 29844737
TI  - Cardiac Magnetic Resonance to Evaluate Percutaneous Pulmonary Valve Implantation
      in Children and Young Adults.
AB  - Experience with cardiac magnetic resonance to evaluate coronary arteries in
      children and young adult patients is limited. Because noninvasive imaging has
      advantages over coronary angiography, we compared the effectiveness of these
      techniques in patients who were being considered for percutaneous pulmonary valve
      implantation. We retrospectively reviewed the cases of 26 patients (mean age,
      12.53 +/- 4.85 yr; range, 5-25 yr), all of whom had previous right ventricular-to
      pulmonary artery homografts. We studied T2-prepared whole-heart images for
      coronary anatomy, velocity-encoded cine images for ventricular morphology, and
      function- and time-resolved magnetic resonance angiographic findings. Cardiac
      catheterization studies included coronary angiography, balloon compression
      testing, right ventricular outflow tract, and pulmonary artery anatomy.
      Diagnostic-quality images were obtained in 24 patients (92%), 13 of whom were
      considered suitable candidates for valve implantation. Two patients (8%) had
      abnormal coronary artery anatomy that placed them at high risk of coronary artery
      compression during surgery. Twelve patients underwent successful valve
      implantation after cardiac magnetic resonance images and catheterization showed
      no increased risk of compression. We attempted valve implantation in one patient
      with unsuitable anatomy but ultimately placed a stent in the homograft. Magnetic
      resonance imaging of coronary arteries is an important noninvasive study that may
      identify patients who are at high risk of coronary artery compression during
      percutaneous pulmonary valve implantation, and it may reveal high-risk anatomic
      variants that can be missed during cardiac catheterization.

PMID- 29844738
TI  - Varying Evidence on Deep Hypothermic Circulatory Arrest in Thoracic Aortic
      Aneurysm Surgery.
AB  - Cardiovascular surgeons have long debated the safe duration of deep hypothermic
      circulatory arrest during thoracic aortic aneurysm surgery. The rationale for
      using adjunctive cerebral perfusion (or not) is to achieve the best technical
      aortic repair with the lowest risk of morbidity and death. In this literature
      review, we highlight the debates surrounding these issues, evaluate the disparate
      findings on deep hypothermic circulatory arrest durations and temperatures, and
      consider the usefulness of adjunctive perfusion.

PMID- 29844739
TI  - New Pulmonary Valvuloplasty Technique by Use of an Hourglass-Shaped Balloon in 3
      Adults with Severe Pulmonary Valve Stenosis.
AB  - Percutaneous balloon pulmonary valvuloplasty is the preferred therapy for
      pulmonary valve stenosis. However, the designs of the cylindrical balloons
      historically used for valvuloplasty have limitations, especially in patients who
      have large pulmonary annular diameters. The hourglass-shaped V8 Aortic
      Valvuloplasty Balloon may prove to be an effective alternative. The balloon has 2
      large bulbous segments that are separated by a narrowed waist. The geometric
      shape is maintained throughout inflation, improving fixation and enabling broader
      leaflet opening. We present our first experience with the V8 balloon in 3 adults
      who had severe, symptomatic pulmonary valve stenosis. In addition to describing
      their cases, we detail our sizing technique for pulmonary valvuloplasty with the
      V8 balloon. Our successful results suggest that the V8 balloon is efficient and
      safe for balloon pulmonary valvuloplasty in adults with severe pulmonary valve
      stenosis.

PMID- 29844740
TI  - Changes in Coronary Plaque Volume: Comparison of Serial Measurements on
      Intravascular Ultrasound and Coronary Computed Tomographic Angiography.
AB  - Serial measurements of coronary plaque volume have been used to evaluate drug
      efficacy in atherosclerotic progression. However, the usefulness of computed
      tomography for this purpose is unknown. We investigated whether the change in
      total plaque volume on coronary computed tomographic angiography is associated
      with the change in segment plaque volume on intravascular ultrasound. We
      prospectively enrolled 11 consecutive patients (mean age, 56.3 +/- 5 yr; 6 men)
      who were to undergo serial invasive coronary angiographic examinations with use
      of grayscale intravascular ultrasound and coronary computed tomography, performed
      <180 days apart at baseline and from 1 to 2 years later. Subjects underwent 186
      serial measurements of total plaque volume on coronary computed tomography and 22
      of segmental plaque volume on intravascular ultrasound. We used semiautomated
      software to examine percentage relationships and changes between total plaque and
      segmental plaque volumes. No significant correlations were found between
      percentages of total coronary and segment coronary plaque volume, nor between
      normalized coronary plaque volume. However, in the per-patient analysis, there
      were strong correlations between the imaging methods for changes in total
      coronary and segment coronary plaque volume (r=0.62; P=0.04), as well as
      normalized plaque volume (r=0.82; P=0.002). Per-patient change in plaque volume
      on coronary computed tomography is significantly associated with that on
      intravascular ultrasound. Computed tomographic angiography may be safer and more
      widely available than intravascular ultrasound for evaluating atherosclerotic
      progression in coronary arteries. Larger studies are warranted.

PMID- 29844741
TI  - Malignant Shamblin III Carotid Body Tumors Resected with Use of the Retrocarotid
      Dissection Technique in 2 Patients.
AB  - Carotid body tumors are rare neoplasms with malignant potential in 6% to 12.5% of
      cases, and surgical resection is the only cure. We present the cases of 2 female
      patients who had expanding, painless, right-sided neck masses; computed
      tomographic angiograms revealed Shamblin III tumors at the carotid bifurcation.
      Each patient underwent tumor resection with use of the retrocarotid dissection
      technique. The tumor specimens were histologically consistent with malignancy,
      and free margins were achieved. The patients remained free of symptoms, local
      recurrence, and metastasis 44 and 19 months after their respective procedures.
      These are the first malignant Shamblin III carotid body tumors that we have
      resected by means of retrocarotid dissection. In addition to our patients' cases,
      we discuss carotid body tumors and compare the retrocarotid and standard
      caudocranial resection techniques.

PMID- 29844742
TI  - Therapeutic Plasma Exchange for Urgent Rivaroxaban Reversal.
AB  - Direct oral anticoagulants, which include the factor Xa inhibitor rivaroxaban,
      have some advantages over vitamin K antagonists in regard to stroke prevention in
      patients with atrial fibrillation. However, no antidotes to reverse the effect of
      oral anticoagulants are commercially available, which can complicate treating
      patients in whom reversal is urgent. We faced this challenge in a kidney
      transplant candidate, a 65-year-old man with end-stage renal disease who had been
      taking rivaroxaban for paroxysmal atrial fibrillation. When a deceased-donor
      kidney became available, we needed to rapidly reduce the patient's bleeding risk,
      while minimizing the cold ischemic time of the donor kidney. Therefore, we
      decided to take an experimental approach and perform therapeutic plasma exchange.
      The patient's plasma anti-factor Xa level decreased from 0.4 IU/mL immediately
      before treatment to 0.21 IU/mL afterward, indicating that rivaroxaban had been
      actively removed from circulation. Waste fluid showed significant anti-Xa
      activity, indicating that the risk of rebound anticoagulation had been mitigated.
      The patient subsequently underwent successful kidney transplantation. To our
      knowledge, this is the first report of therapeutic plasma exchange to reverse the
      effects of rivaroxaban in a patient undergoing urgent surgery. This treatment may
      also be suitable for patients who have life-threatening, large-volume bleeding,
      especially in the presence of substantial kidney or liver dysfunction.

PMID- 29844743
TI  - Distal Left Main Coronary Artery Aneurysm Resection during 5-Vessel Coronary
      Artery Bypass Grafting.
AB  - Coronary artery aneurysms are abnormal dilations of arterial segments, in some
      cases associated with underlying atherosclerosis. Although affected patients can
      be asymptomatic, some are at risk of plaque rupture, dissection, and other
      complications. Investigations into the optimal management of these vascular
      malformations are ongoing, because no consensus exists regarding when and how
      best to intervene. We present the case of a 58-year-old man whose large left main
      coronary artery aneurysm we ligated and removed during 5-vessel coronary artery
      bypass grafting. This distal aneurysm was at the trifurcation level of the
      patient's left anterior descending and left circumflex coronary arteries. In
      addition, we discuss considerations about left main coronary artery aneurysms and
      their treatment.

PMID- 29844744
TI  - Murmur Associated with Diastolic Paradoxical Jet Flow in a 43-Year-Old Man with
      Hypertrophic Cardiomyopathy.
AB  - A diastolic paradoxical jet flow, often seen in patients with hypertrophic
      cardiomyopathy, is a unique flow from the apex toward the base of the left
      ventricle during isovolumic relaxation. To date, this phenomenon appears to have
      been noninvasively detected only on echocardiograms. We report the case of a 43
      year-old man with hypertrophic cardiomyopathy and a diastolic paradoxical jet
      flow, in whom cardiac auscultation revealed a soft S4, a systolic ejection
      murmur, and a low-pitched early diastolic murmur immediately after S2 at the
      apex. On comparing his echocardiographic findings with those on phonocardiograms
      and apexcardiograms, we confirmed that the unusual murmur coincided with the
      diastolic jet flow. To our knowledge, this is the first case in which heart
      murmurs associated with a diastolic paradoxical jet flow have been clearly
      described. Because these flows can increase the risk of adverse outcomes,
      detecting any associated murmurs by methods other than echocardiography is
      worthwhile, even in the era of advanced imaging techniques.

PMID- 29844745
TI  - Recurrent Spontaneous Coronary Artery Dissection in 4 Vascular Territories.
AB  - Spontaneous coronary artery dissection, a rare cause of acute coronary syndrome,
      is due to nonatherosclerotic coronary events and is probably underrecognized as a
      cause of myocardial infarction. The condition typically affects premenopausal
      women who are otherwise healthy. Among more than 1,200 reported cases, recurrent
      dissection has been described 63 times, and only 3 reports have documented
      multiple episodes of dissection involving different vascular territories. We
      present the case of a woman in her 30s who, over a 9-year period, presented 4
      times with coronary dissection in different vascular territories. She was first
      treated conservatively, then with stents, and ultimately by means of coronary
      artery bypass grafting. In addition to this case, we discuss this rare condition
      and its management.

PMID- 29844746
TI  - Long-Term Continuous-Flow Biventricular Support in a 63-Year-Old Woman.
AB  - We describe the successful use of long-term biventricular continuous-flow
      mechanical circulatory support as a bridge to transplantation in a small-framed
      63-year-old woman with long-standing nonischemic cardiomyopathy. After placement
      of a left-sided HeartWare HVAD, persistent right-sided heart failure necessitated
      implantation of a second HeartWare device for long-term right ventricular
      support. After 262 days, the patient underwent successful orthotopic heart
      transplantation and was discharged from the hospital. This report indicates the
      feasibility of biventricular device support in older patients of relatively small
      stature, and our results may encourage others to consider this therapy in similar
      patient populations.

PMID- 29844747
TI  - Slow, But Dangerous.

PMID- 29844748
TI  - Pericardial Rupture with Intermittent Cardiac Luxation.

PMID- 29844749
TI  - Caught in the Act: Paradoxical Emboli.

PMID- 29844751
TI  - Erratum.
AB  - [This corrects the article on p. 29 in vol. 44, PMID: 28265210.].

PMID- 29844750
TI  - Continuous Suture Technique for Aortic Valve Replacement.

PMID- 29844752
TI  - The Epileptogenic Zone: Concept and Definition.
AB  - A "concept" refers to what exists in the mind as a representation (as in
      something comprehended) or as a formulation (as in a plan). It is generally
      understood as "any idea of what a thing ought to be" (Merriam-Webster). From that
      premise, an "idea" cannot be compartmentalized or rigidly defined as exclusively
      belonging to any single individual or school of thought. The utility of a concept
      is inherently linked to its adaptability to the needs and conditions of the time.
      I state this upfront because over the past several decades, the concept of the
      epileptogenic zone (EZ) has become so crucial to the foundation of major schools
      of surgical epilepsy that discussions and opinions on the topic have essentially
      sought to legitimize one view while criticizing the other. This review is not a
      referendum on any specific definition of the EZ but rather a chronological
      analysis of the historical evolution of this concept and the invasive EEG tools
      used to study it. The goal is to highlight common ground necessary to tackle the
      ever-present challenge of defining the ideal resection for a patient with drug
      resistant focal epilepsy.

PMID- 29844753
TI  - Depression Screening Tools: More Hammers, Fewer Nails.

PMID- 29844754
TI  - Knowing Is Half the Battle: Underestimating SUDEP.

PMID- 29844755
TI  - Two Studies, One Message: High Yield of Genetic Testing in Infants and Young
      Children With Severe Epilepsies.

PMID- 29844756
TI  - Less Effective and More Expensive: Is It Time to Move on From Rectal Diazepam?

PMID- 29844757
TI  - The Disruptive Nature of Focal Developmental Insults.

PMID- 29844758
TI  - Cognitive Problems in Epilepsy: Are Interictal Epileptiform Discharges to Blame?

PMID- 29844759
TI  - Cannabidiol and Serum Antiepileptic Drug Levels: The ABCs of CBD With AEDs.

PMID- 29844760
TI  - Do Seizures Induce Brain Tissue Loss?

PMID- 29844761
TI  - Circadian Profile and Seizure Forecasting: Still Cloudy but With Chance for
      Sunshine.

PMID- 29844762
TI  - Seizures in Tuberous Sclerosis: Mechanism-Based Interventions EXIST.

PMID- 29844763
TI  - Persistent Protection Against Pathology and Paroxysms by P2X7R Antagonism.

PMID- 29844764
TI  - Disease-Modification in Epilepsy by Nonpharmacological Methods.

PMID- 29844765
TI  - Focusing on the Big Picture: Induced Focal Seizures Propagate Along Synaptic
      Pathways.

PMID- 29844766
TI  - Back to the Dentate: Network Changes of Early- and Late-Born Dentate Granule
      Cells.

PMID- 29844767
TI  - Neonatal Seizures: Is the Remedy Worse Than the Disease?

PMID- 29844768
TI  - Lost Inhibition - Brain Activity Temporarily Out of Control.

PMID- 29844769
TI  - Expanding the Zebrafish Toolkit for Epilepsy Research.

PMID- 29844770
TI  - Thermally stable hybrid polyarylidene(azomethine-ether)s polymers (PAAP): an
      ultrasensitive arsenic(III) sensor approach.
AB  - A new category of thermally stable hybrid polyarylidene(azomethine-ether)s and
      copolyarylidene(azomethine-ether)s (PAAP) based on diarylidenecycloalkanones has
      been synthesized using solution polycondensation method. For potential cationic
      sensor development, a thin layer of PAAP onto a flat glassy carbon electrode
      (GCE, surface area: 0.0316 cm2) was prepared with conducting nafion (5%) coating
      agent to fabricate a sensitive and selective arsenic (III) [As3+] ion in short
      response time in neutral buffer system. The fabricated cationic sensor was
      measured the analytical performances such as higher sensitivity, linear dynamic
      range, detection limit, reproducibility, and long-term stability towards As3+
      ions. The sensitivity and detection limit were calculated as 2.714 MUAMUM-1cm-2
      and 6.8 +/- 0.1 nM (SNR of 3; 3N/S) respectively from the calibration curve. This
      novel approach can be initiated a well-organized route of an efficient
      development of heavy selective arsenic sensor for hazardous pollutants in
      biological, environmental, and health care fields. Real sample analysis for
      various environmental sample was performed with PAAP-modified-GCE.

PMID- 29844771
TI  - A Special Issue: Pharmaconosy.

PMID- 29844773
TI  - Investigation of Antioxidative, Cytotoxic, Membrane-Damaging and Membrane
      Protective Effects of The Essential Oil of Origanum majorana and its Oxygenated
      Monoterpene Component Linalool in Human-Derived Hep G2 Cell Line.

PMID- 29844772
TI  - Black Seed (Nigella Sativa) and its Constituent Thymoquinone as an Antidote or a
      Protective Agent Against Natural or Chemical Toxicities.
AB  - Nigella sativa(N. sativa), which belongs to the botanical family of
      Ranunculaceae, is a widely used medicinal plant all over the world. N. sativa
      seeds and oil have been used in the treatment of different diseases. Various
      studies on N. sativa have been carried out and a broad spectrum of its
      pharmacological actions have been established which include antioxidant,
      antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial,
      anti-inflammatory, spasmolytic, and bronchodilator. This is also indicated that
      the majority of the therapeutic effects of N. sativa are due to the presence of
      thymoquinone (TQ) that is the main bioactive constituent of the essential oil.
      According to several lines of evidence, the protective effects of this plant and
      its main constituent in different tissues including brain, heart, liver, kidney,
      and lung have been proved against some toxic agents either natural or chemical
      toxins in animal studies. In this review article, several in-vitro and animal
      studies in scientific databases which investigate the antidotal and protective
      effects of N. sativa and its main constituents against natural and chemical
      induced toxicities are introduced. Because human reports are rare, further
      studies are required to determine the efficacy of this plant as an antidote or
      protective agent in human intoxication.

PMID- 29844774
TI  - Cardioprotective Effects of Methanolic Extract of Scrophularia frigida on
      Ischemia-Reperfusion-Induced Injuries in Isolated Rat Heart.
AB  - Myocardial infarction is a common presentation of coronary artery disease and the
      leading cause of death worldwide. The present study investigated potential
      resistance to ischemia-reperfusion (I/R) injuries following administration of
      methanolic (MeOH) extract of Scrophularia frigida (S. frigida) in isolated rat
      heart. Male Wistar rat hearts (n= 8-10) were isolated and allowed to equilibrate
      for 20 min, and then subjected to 30 min regional ischemia followed by 120 min
      reperfusion. In the control group, Krebs-Henseleit (K/H) solution was perfused.
      However, in the treatment groups K/H solution containing 1, 5, and 10 ug/cc of
      extract was infused. In addition, total phenol, total flavonoid content and
      antioxidant property were evaluated and extract was subjected to phytochemical
      analysis. Administration of extract improved the flow rate, developed pressure as
      well as max and min left ventricular dp/dt. Number and duration of VT were
      significantly reduced by all extract concentrations in ischemic phase. In
      reperfusion phase, significant decreases in single and total arrhythmias were
      seen. Furthermore, concentrations of 5 and 10 ug/cc of extract remarkably
      decreased the infarct size. Generally, the methanolic extract of S. frigida
      exhibited a protective effect against I/R-induced injures, which might be due to
      the antioxidant activiies of iridoids and phenolics.

PMID- 29844775
TI  - Bioactivity-guided Study of Passiflora caerulea L. Leaf Extracts.
AB  - Passiflora species were known by their anticonvulsant, anxiolytic and sedative
      activities. The aim of this study was to investigate the chemical composition of
      the most active leaf extract of Passiflora caerulea L. grown in Egypt. The
      ethanolic extract of the leaves exhibited higher activity than aqueous extract as
      anticonvulsant (63% potency relative to carbamazepine), analgesic (70% potency
      relative to indomethacin), antioxidant (71% potency relative to vitamin E), anti
      inflammatory (90% potency relative to indomethacin) and antipyretic (90% potency
      relative to paracetamol). Fractions obtained successively from the ethanolic
      extract were then subjected to the same biological testing demonstrating that the
      ethyl acetate fraction was the most active in all activities (50, 96, 80, 63 %
      potency relative to reference standards used in each of the selected activity,
      respectively) followed by n-butanol then n-hexane and chloroform fractions.
      Purification of the anticonvulsant sub-fractions obtained by column
      chromatography of ethyl acetate fraction, led to the isolation of three compounds
      that were identified by physical and spectroscopic techniques as Lucenin II (1),
      4-hydroxycinnamic acid (2) and Chrysin 6-C-beta-D-glucoside (3). The amount of
      Chrysin 6-C-beta-D-glucoside was found to be 0.0184 g % w/w of the dried leaves
      using HPLC method that showed linearity (R2 = 0.9996) over the range 0.015-0.25
      mg/mL. C-glycosyl flavones and hydroxycinnamic acid derivatives may thus be the
      responsible principles for the biological activity of the plant under
      investigation. Moreover, RAPD technique was performed for the genetic
      characterization and authentication of the plant, where 106 fragments were
      recorded after DNA amplification with fifteen primers.

PMID- 29844776
TI  - Isolation and Identification of Secondary Metabolites from the Aerial Parts of
      Stachys lavandulifolia Vahl.
AB  - Stachys lavandulifolia Vahl is an herbaceous wild plant native to Iran which is
      traditionally used in Iranian folk medicine as a mild sedative tea for reducing
      anxiety and for treatment of gastrointestinal disorders. Our previous study on
      ethyl acetate extract of S. lavandulifolia proved anti-anxiolytic activity and so
      the present study was designed to determine chemical components of this
      biologically active fraction. The extract was prepared using maceration method.
      Column chromatography and medium pressure liquid chromatography (MPLC) was used
      respectively to separate the fractions. Finally, some evaluated fractions were
      used for high pressure liquid (HPLC) and peak shaving recycle technique to
      achieve more purification. Separated compounds were determined using NMR analysis
      and mass spectroscopy. Six compounds have been isolated from ethylacetate extract
      of aerial parts of S. lavandulifolia including four flavonoids (apigenin,
      kumatakenin, penduletin and 4', 7-dihyroxy- 3, 5, 6-trimethoxy flavon), a labdan
      diterpenoid (labda-13-en-8, 15-diol), and an iridoid.

PMID- 29844777
TI  - Comparative Analysis of Chemical Profile, Antioxidant, In-vitro and In-vivo
      Antidiabetic Activities of Juniperus foetidissima Willd. and Juniperus sabina L.
AB  - Fruit and leaves of junipers are commonly used internally as tea and pounded
      fruits are eaten to lower blood glucose levels in Anatolia. Thus, we aimed to
      evaluate antidiabetic and antioxidant potential and the chemical profile of
      Juniperus foetidissima Willd. and J. sabina L. in this study. In-vitro
      antidiabetic activities of leaf and fruit extracts were examined by their
      inhibitory activity on alpha-glucosidase and alpha-amylase enzymes. Then, in-vivo
      antidiabetic activities of leaf and fruit extracts of Juniperus species were
      investigated on streptozotocin-induced diabetic rats. Additionally, antioxidant
      activities (phosphomolybdenum, ferric-reducing antioxidant power and ABTS radical
      scavenging activity assays), phytochemical screening tests and high performance
      liquid chromatography analysis (HPLC) were done. In-vitro enzyme inhibitory
      effects of the extracts were supported by the results of in-vivo antidiabetic
      activity studies. Phytochemical screening tests indicated presence of flavonoids,
      tannins, terpenoids and carbohydrates in the extracts. Amentoflavone was
      identified as the major compound in the extracts and content of amentoflavone was
      determined. As a result, Juniperus extracts and its active constituents might be
      beneficial for diabetes and its complications.

PMID- 29844778
TI  - Study of Hypoglycemic, Hypocholesterolemic and Antioxidant Activities of Iranian
      Mentha Spicata Leaves Aqueous Extract in Diabetic Rats.
AB  - This study was conducted to evaluate the hypoglycemic, hypocholesterolemic and
      antioxidant properties of Mentha spicata (Labiateae) leaves aqueous extract
      (MSLA) in alloxan-induced diabetic rats. In this study, hyperglycemia was induced
      in male rats by intraperitoneal injection of alloxan monohydrate (150 mg/kg). The
      aqueous extract of M. spicata was orally administered at a dose of 300 mg/kg body
      weight to diabetic rats for 21 days and the effects were compared with
      glibenclamid (2 mg/kg). Fasing blood sugar (FBS), body weight, lipid profile and
      serum malondialdehyde (MDA) were monitored at 0, 7, 14 and 21 days after
      induction of diabetes. Total phenol contents (TP) and reducing power (RP) were
      also evaluated. TP and RP of aqueous extract were 2.763 +/- 0.39 mg Galic acid/gr
      and 0.026 +/- 0.001 EC50 mg/mL, respectively. The LD50 of the extract was found
      to be ? 1500 mg/kg. The administration of M. spicata aqueous extract produced a
      significant reduction (P?0.01) in FBS, total cholesterol, triglyceride, low
      density lipoprotein-cholesterol and MDA (101.83 +/- 4.33, 95.66 +/- 4.75, 89.83
      +/- 5.26, 26.20 +/- 5.10 mg/dl and 1.53 +/- 0.61 umol/l, respectively) in
      diabetic rats. These effects were comparable with the effects of standard
      antidiabetic drug (glibenclamide). The results of the investigation indicated
      that M. spicata leaf aqueous extract possess hypoglycemic, hypocholesterolemic
      and antioxidant properties in diabetic rats. Therefore, this study suggest a
      promising use of it for treatment of diabetes.

PMID- 29844779
TI  - Anti-oxidant and Anti-Inflammatory Cyclic Diarylheptanoids from Alnus japonica
      Stem Bark.
AB  - A new cyclic diarylheptanoid namely alnuheptanoid B (3), along with four known
      cyclic diarylheptanoids: myricanone (1), (+)-S-myricanol (2), myricanone 5-O- -D
      glucopyranoside (4), and (+)-S-myricanol 5-O- -D-glucopyranoside (5) were
      isolated from the EtOAc fraction of Alnus japonica Steud (family: Betulaceae)
      stem bark. Their structures were established by different spectroscopic analyses,
      as well as optical rotation measurement. Compounds 1, 2, 4, and 5 are isolated
      for the first time from A. japonica. The antioxidant and anti-inflammatory
      activities of compounds (1-5) were assessed using DPPH assay and carrageenin
      induced rat paw edema model, respectively. They displayed significant antioxidant
      activity in relation to propyl gallate (standard antioxidant) at concentration 50
      uM. Compound 2 demonstrated anti-inflammatory effect at a dose 10 mg/kg compared
      with indomethacin (positive control).

PMID- 29844780
TI  - In-vitro Antioxidant Activities of the Ethanolic Extracts of Some Contained
      Allantoin Plants.
AB  - It has been investigated the in-vitro antioxidant properties of ethanol extracts
      of the contained-allantoin plants in this study. Contained-allantoined plant
      samples Plantago lanceolata, Plantago major, Robinia pseudoacacia, Platanus
      orientalis and Aesculushippocastanum were tested at different concentrations. The
      antioxidant activities of plant samples were analysed by 1,1- diphenyl-2
      picrylhydrazyl (DPPH) radical scavenging method, cupric reducing antioxidant
      capacity (CUPRAC), reducing power assay and beta-carotene bleaching method.
      Plantago major plant showed the highest antioxidant capacity compared to other
      plant extracts in results of the in-vitro assays including 1,1- diphenyl-2
      picrylhydrazyl (DPPH) radical scavenging method with 90.25 %, cupric reducing
      antioxidant capacity (CUPRAC) with 1.789 %, reducing power assay (FRAP) with
      1.321 % and beta-carotene bleaching method with 78.01 % in 1 mg/mL. The lowest
      antioxidant activity was determined in Robinia pseudoacacia plant. In conclusion,
      allantoin shows antioxidant properties and it has the positive effect on total
      antioxidant capacity.

PMID- 29844781
TI  - Effects of Phytoestrogens in Alleviating the Menopausal Symptoms: A Systematic
      Review and Meta-Analysis.
AB  - The aim of this study was to perform a meta-analysis of high-quality, randomized,
      controlled trials (RCTs), to investigate the effectiveness of phytoestrogens in
      alleviating the menopausal symptoms (vaginal atrophy). Variety of databases
      including PubMed, Scopus, and Cochrane Central Register of Controlled Trials
      (CCRCT) were searched up to May 2015 according to the below-mentioned pre
      specified search strategy and using the relevant MeSH terms. The mean difference
      was applied as an estimate of the main effect size. Moreover, due to the
      considerable heterogeneity among studies, the random-effects model was used to
      obtain the pooled effect size derived from primary studies. Results showed that
      while the standardized mean difference of vaginal cell maturation index was
      increased up to 0.164 percent (with the confidence interval at 95%: (-0.419
      0.746), but this increase was not statistically significant (P=0.582). The
      absence of the publication bias was confirmed using the Egger's regression
      intercept test (P = 0.24). Also, meta-analysis of soybeans studies showed that
      while the standardized mean difference of vaginal maturation index increased
      0.072% in (95% CI: -0.42 to 0.5.), this increase was not statistically
      significant (p = 0.777). The results confirm that soybeans and phytoestrogens
      have non-significant positive effects on the vaginal atrophy index. Hence, it is
      suggested that with regard to non-significant positive effects, non-hormonal
      treatments along with other treatments such as the vaginal gels and so on should
      be used more in cases with non-severe vaginal atrophy.

PMID- 29844782
TI  - Efficacy of Supportive Therapy of Allergic Rhinitis by Stinging Nettle (Urtica
      dioica) root extract: a Randomized, Double-Blind, Placebo- Controlled, Clinical
      Trial.
AB  - The aim of this study was to survey the exact benefit of this herb in the
      management of clinical and laboratory signs and symptoms of allergic rhinitis. In
      a randomized double blind clinical trial, 74 patients with the signs and symptoms
      of allergic rhinitis and a positive skin prick test were selected and randomly
      divided into 2 groups who were takenUrtica dioica 150-mg, Urtidin(r) F.C Tablet)
      or placebo for one month. Their signs and symptoms, eosinophil percentage on
      nasal smear, serum IgE, and interleukin IL-4, IL-5, interferon- gamma) levels
      were recorded. Forty patients completed the trial. Based on the Sino- Nasal
      Outcome Test 22 SNOT-22), a significant improvement in clinical symptom severity
      was observed in both groups P < .001). Furthermore, a statistically significant
      reduction in mean nasal smear eosinophil count was observed after treatment with
      Nettle P < .01). However, the mean IgE and IL4 and IL5 levels in the study group
      before and after treatment with Nettle saw no significant changes P > .1).
      Intergroup pre- and post-treatment laboratory findings suggested that there was a
      significant difference in post-treatment changes of mean IFN gamma levels between
      the study and placebo group P = 0.017). Although the current study showed certain
      positive effects of Nettle in the management of allergic rhinitis on controlling
      the symptoms based on the SNOT-22, similar effects were demonstrated by placebo
      as well. We believe that our limitations underscore the need for larger, longer
      term studies of Nettle for the treatment of allergic rhinitis.

PMID- 29844783
TI  - Antioxidant, Antimutagenic, Tanning and Calpain Induction Activities of
      Methanolic Extract of Tunisian Plant (Moricandia Arvensis).
AB  - In this study, we investigate the potential of Moricandia arvensis methanol leaf
      extract (MeOHL) on calpain activity, melanin biosynthesis and DNA mutagenicity.
      Cytotoxic effect and measurement of reactive oxygen species (ROS) induced by
      lucigenin in colorectal cells (BE) were also determined. In addition, the
      chemical analysis of the extract was also studied and the chemical profile
      illustrates its content in para-hydroxybenzoic acid (p-HBA), a glycosylated
      kampferol (GK), a glycosylated kampferol with Rhamnose (GKR) and 19 amino acids
      (AAs). Our results showed that MeOHL extract enhanced a significant cytotoxic
      (max of IP = 89.23%) and antioxidant (max of IP=100%) activities. Furthermore,
      the tested extract stimulated calpain activity and significantly increased the
      production of intra (46 ug/mL cells) and extracellular melanin content
      (12.5ug/mL). Using Ames assay, the extract exhibits a significant inhibition of
      mutagenicity induced by methy-methane-sulfonate (MMS) (76.32%) as well as 2
      aminoanthracene (2-AA) (91%) in the Salmonella thyphimurium TA104 assay system.

PMID- 29844784
TI  - Evaluation of Hepatoprotective Effect of Acantholimon Gilliati Eerial Part
      Methanolic Extract.
AB  - The aerial parts of Acantholimon gilliati was extracted by n-hexane,
      dichloromethane and methanol. Methanolic extract tested for hepatoprotective
      effects on formaldehyde liver injury in mice. The maximum effect that the
      methanolic extract showed protective effect on this experiment against
      formaldehyde observed in 5 and 10 mg. Also other concentrations of this extract
      showed positive effect compared to toxicant on morphology and biochemical factors
      of the liver. Results showed that the methanolic extract of the A. gilliati has a
      protective include functional and enzymatic stablingeffect on liver.

PMID- 29844785
TI  - Phenolic Profile, Antiradical and Antitumour Evaluation of Raspberries Pomace
      Extract from Serbia.
AB  - Raspberry waste, obtained from two cultivars, Meeker (ERM) and Willamette (ERW)
      was subjected to evaluation antioxidants and antitumour activities as a potential
      source of phenolics. Some phenolic acids and flavonoids were identified and
      quantified by HPLC. Antioxidant activity was tested by measuring ability to
      scavenge DPPH* and *OH by ESR spectroscopy. IC50DPPH* varied from 0.67 for ERM to
      0.54 mg/mL for ERW, while IC50*OH values varied from 3.73 for ERM to 1.23 mg/mL
      for ERW. Cytotoxic activity was investigated using in vivo model of Ehrlich
      Ascite carcinoma cells (EAC) in mice. Pretreatment with extracts exhibited potent
      cytotoxic activity against EAC cells (up to 60%) and both extracts inhibited the
      tumour growth. Activity of xanthine oxidase (XOD) was extremely increased in
      pretreated animals, while the activity of enzyme complex glutathione reductase
      (GR) and glutathione peroxidase (GSHPx) was significantly increased. This study
      suggests that raspberry pomace could be used as nutraceutic resource and
      functional food ingredient.

PMID- 29844786
TI  - Evaluation of the Wound Healing Activity of a Traditional Compound Herbal Product
      Using Rat Excision Wound Model.
AB  - Iranian Traditional Medicine (ITM) manuscripts contain prescriptions that have
      long been used for healing of wounds. The present study evaluates the healing
      effect of a poly herbal paste (PHP), retrieved from ITM sources, containing Aloe
      vera, Commiphora myrrha and Boswellia carteri using rat excision wound model.
      Excision wounds were induced in six groups consisting of six rats each. Group 1
      received no treatment, while groups 2 and 6 received tetracycline ointment, Alpha
      ointment, PHP 40%, PHP 10% and paste base every day, respectively. The percentage
      of wound contraction on days 2, 7, 14 and 21 and histopathology parameters of
      healed wounds on 14th and 21st days were evaluated. Moreover, antioxidant
      activity of PHP was evaluated using DPPH method. There was a significant
      improvement in wound healing in PHP 10% group on the 7th day of the treatment
      (p<0.05). Moreover, the healing effect of PHP 10% was significantly greater than
      the control, tetracycline and paste base groups on the 2nd, 14th and 21st days
      (p<0.05). On day 14, PHP 40% showed significant healing effect compared to the
      control, tetracycline and paste base groups (p<0.05). Fewer inflammatory cells
      were observed in PHP 10%-treated animals and this group demonstrated better re
      epithelialization with remarkable neovascularization. Besides, the PHP 10%
      formulation exhibited antioxidant activity. In vivo and histopathologic
      examinations showed considerable wound healing in PHP 10% group. This finding
      could probably be due to the antioxidant, anti-inflammatory and antimicrobial
      activities of phytoconstituents of A. vera, B. carteri and C. myrrha.

PMID- 29844787
TI  - Effects of Stinging Nettle (Urtica Dioica L.,) on Antioxidant Enzyme Activities
      in Rat Model of Mammary Gland Cancer.
AB  - Stinging nettle (Urtica dioica L.,) is a medicinal herb commonly used by humans.
      The role of reactive oxygen metabolites on cancer etiology is known. There are
      some studies about the antioxidant effects of Urtica Dioica (UD) on therapy of
      some cancer types. This study aimed to investigate the effects of UD on
      antioxidant enzyme activities and mammary gland cancer induced by in rats-N
      methyl-N-nitrosourea (NMU) carcinogenesis. Rats were divided into four groups: a
      untreated group (Group 1), a NMU group (Group 2) given 50 mg/kg NMU by
      intraperitoneal (i.p.) injection, a NMU group (Group 3) treated with UD, a
      control group (Group 4) fed with 50g/kg UD. After 5.5 months, rats were
      decapitated, and mammary tissue and blood samples were obtained. There was a
      significant (p<0.05, p<0.01, respectively) increase in plasma malondialdehyde
      (MDA) levels of group 2 compared with group 1 and 4. The superoxide dismutase
      (SOD) activity of the erythrocytes was decreased in group 3 than the other groups
      (p<0.0001). The erythrocyte catalase (CAT) activity was significantly increased
      in group 4 compared with group 2 and 3 (p<0.05, p<0.01, respectively). The number
      of animals with palpable tumors was 6 (46.15%) in group 2, and 2 (13.3%) in group
      3 at the end of the 22nd week. Although group 3 had lower palpable tumor number
      than group 2, the difference was not statistically significant (p=0.096). The
      results showed that UD constituents may have effects on lipid peroxidation and
      some antioxidant enzyme activities, and may slow the formation of mammary tumor.

PMID- 29844788
TI  - The Effect of Melissa Officinalis Extract on the Severity of Primary Dysmenorrha.
AB  - Primary dysmenorrhea refers to painful cramps during menstruation with no organic
      reason. With respect to its high incidence and adverse outcomes in quality of
      life and some evidences regarding the sedative and antispasmodic effects of
      Melissa officinailson smooth muscles as an herb, this double-blind clinical trial
      was conducted to determine the effects of its capsules on severity of
      dysmenorrhea in the students of Islamic Azad University of Zanjan in 2014. 110
      students were matched in terms of dysmenorrhea severity and experience; age;
      menarche; body mass index (BMI); occupation as well as educational level of
      parents; and duration, interval as well as amount of bleeding. Then, they were
      randomly divided into 2 herb (55 subjects) and placebo (55 subjects) groups. The
      former was given capsules 330 mg of the herb 3 times a day over 3 days at the
      onset of hemorrhage while the latter was given placebo in similar capsules
      containing corn starch with the same protocol. Pain severity was evaluated with a
      visual analogue scale (0 to 10 cm). Different statistical tests were used for
      data analysis with SPSS package. No significant difference was found between the
      means of pain severity in the groups before the intervention. However, the
      severity was reduced in both groups after the intervention (P<0.001) but the
      amount of it was more in Melissa group with a significant difference (P<0.05).
      With respect to the findings, it seems that M. officinalismay decrease
      dysmenorrhea, which may be related to antispasmodic effects of this herb.

PMID- 29844789
TI  - Comparative Evaluation of Phenolic Profile, Antioxidative and Cytotoxic
      Activities of Different Geranium Species.

PMID- 29844790
TI  - Antibacterial Activityand Comparison of the Volatile Oils of Tanacetum
      tenuisectum (Boiss.) Podl. Obtained by Three Different Methods of Extraction.
AB  - The essential oils obtained by hydrodistillation (HD), steam distillation (SD)
      and solvent free microwave extraction (SFME) from the stems and flowers of
      Tanacetumtenuisectum (Boiss.) Podl., which is endemic to Iran, were analyzed by
      combination of GC and GC/MS. Camphor (26.91 %, 27.23% and 25.52%), borneol
      (12.61%,11.48% and 7.62%) and 1,8-cineole (7.93%, 13.23% and 11.26%) were the
      main constituents of the HD,SD and SFME oils of Tanacetumtenuisectum
      respectively. All three oils were rich in regard to monoterpenes and small
      percentage of sesquiterpenes and non terpenoid compounds. Antibacterial activity
      of the essential oil of the plant was determined against six Gram positive and
      Gram negative bacteria. The results showed that this oil was active against all
      of the tested bacteria.

PMID- 29844791
TI  - Protective Effects of Dendrobium nobile against Cisplatin Nephrotoxicity Both In
      vitro and In-vivo.
AB  - Dendrobium genus was reported to contain alkaloid, bibenzyl, fluorenone,
      phenanthrene, sesquiterpenoid, and phenolic acid, which have biological
      properties. Our aim was to investigate the protective effect of an aqueous
      extract of Dendrobium nobile Lindl (DNE) against cisplatin-induced acute kidney
      injury (AKI). Quantification of four phenolic acids (4-hydroxybenzoic, vanillic,
      syringic, and ferulic acid) in DNE was determined using the HPLC-photodiode array
      method. Possible protective effects against cisplatin-induced nephrotoxicity were
      investigated using in-vitro (porcine kidney cells; PK15) and in-vivo (Sprague
      Dawley rat) studies. Among the four phenolic acids, 4-hydroxybenzoic acid was the
      most abundant. In the in-vitro study, DNE pretreatment partially prevented
      decrement of viability after cisplatin (15 MUg/mL) treatment in the both the MTT
      and crystal violet assays. Moreover, relative to cells treated with cisplatin
      alone, the DNE (50 MUg/mL)-pretreated cells showed a ~30% increase in glutathione
      levels and a ~15% decrease in reactive oxygen species. The expression of p53 was
      also decreased in DNE-pretreated cells (p < 0.05). In the in-vivo study, the
      renal function index decreased to normal levels in groups pretreated with DNE
      (300 and 500 mg/kg); histopathological alterations and apoptotic cells were also
      attenuated. Moreover, DNE pretreatment ameliorated oxidative stress in the
      kidney, as evidenced by recovered antioxidant enzyme levels and decreased lipid
      peroxidation. DNE, by decreasing oxidative stress, was found to have a protective
      effect against cisplatin-induced nephrotoxicity. Based on these findings, DNE
      might be beneficial when treating cisplatin-induced AKI.

PMID- 29844792
TI  - Isolation of Phenolic Derivatives and Essential Oil Analysis of Prangos ferulacea
      (L.) Lindl. Aerial Parts.
AB  - Prangos ferulacea (L.) Lindl. (Apiaceae) is a medicinal plant distributed in
      Mediterranean regions, Caucasia and southwest of Asia. In the present study
      phytochemical constituents of the extract obtained from the aerial parts of P.
      ferulacea were investigated using various chromatographic and spectroscopic
      methods. Essential oil of the plant aerial parts was also analyzed using GC-MS.
      Five phenolic derivatives, isoimperatorin (1), ferudenol (2), caffeic acid
      glucosyl ester (3), isorhamnetin-3-O-beta-D-glucopyranoside (4) and quercetin-3-O
      beta-D-glucopyranoside (5) were isolated from the aerial parts of P. ferulacea
      and their structures were elucidated using 1H-NMR, 13C-NMR, EI-MS and UV spectral
      analyses. Twenty-seven compounds were also identified in the essential oil of
      plant aerial parts, of which beta-pinene (43.1%), alpha-pinene (22.1%) and 
      delta3-carene (16.9%) were characterized as main compounds. The results of this
      study introduce P. ferulacea as a source of potentially bioactive phenolic
      compounds and suggest it as an appropriate candidate for further studies.

PMID- 29844793
TI  - Evaluation of the Cytotoxic Effect of the Brittle Star (Ophiocoma Erinaceus)
      Dichloromethane Extract and Doxorubicin on EL4 Cell Line.
AB  - Leukemia is a blood disease that creates from inhibition of differentiation and
      increased proliferation rate. The nature has been known as a rich source of
      medically useful substances. High diversity of bioactive molecules, extracted
      from marine invertebrates, makes them as ideal candidates for cancer research.
      The study has been done to investigate cytotoxic effects of dichloromethane
      brittle star extract and doxorubicin on EL4 cancer cells. Blood cancer EL4 cells
      were cultured and treated at different concentrations of brittle star (Ophiocoma
      erinaceus) dichloromethane extract at 24, 48 and 72 h. Cell toxicity was studied
      using MTT assay. Cell morphology was examined using an invert microscope.
      Further, apoptosis was examined using Annexin V-FITC, propodium iodide, DAPI, and
      Acridine orange/propodium iodide staining. Eventually, the apoptosis pathways
      were analyzed using measurement of Caspase-3 and -9 activity. The statistical
      analysis was performed using SPSS, ANOVA software, and Tukey's test. P<0.05 was
      considered to be significant. MTT assay and morphological observations showed
      that dichloromethane extract can inhibit cell growth in a dose dependent. The
      results considered 32 ug/mL of the extract as IC50. Also, doxorubicin suppressed
      EL4 proliferation as IC50=32 ug/mL. All experiments related to apoptosis analysis
      confirmed that dichloromethane brittle star extract and doxorubicin have a
      cytotoxic effect on EL4 cells inIC50 concentration. The study showed that
      dichloromethane brittle star extract is as an adjunct to doxorubicin in treatment
      of leukemia cells.

PMID- 29844794
TI  - Relationship Between Temperaments of Herbal Diuretics and Their Effects Based on
      Avicenna's Teaching.

PMID- 29844796
TI  - Phase IV study of retention on fingolimod versus injectable multiple sclerosis
      therapies: a randomized clinical trial.
AB  - Objective: In relapsing-remitting multiple sclerosis (RRMS), suboptimal adherence
      to injectable disease-modifying therapies (iDMTs; interferon beta-1a/b,
      glatiramer acetate) is common, reducing their effectiveness. Patient retention on
      oral fingolimod and iDMTs was evaluated in PREFERMS, a randomized, parallel
      group, active-controlled, open-label, 48-week study. Methods: Patients were
      included if they had RRMS, were aged 18-65 years and had Expanded Disability
      Status Scale score up to 6, enrolled at 117 US study sites, were treatment naive
      or had received only one iDMT class. Patients were randomized 1:1 (fingolimod 0.5
      mg/day; preselected iDMT) by interactive voice-and-web-response system without
      blinding, followed up quarterly, and allowed one study-approved treatment switch
      after 12 weeks, or earlier for efficacy or safety reasons. The primary outcome
      was patient retention on randomized treatment over 48 weeks. Secondary endpoints
      included patient-reported outcomes, brain volume loss (BVL), and cognitive
      function. Results: Analysis of 433/436 patients receiving fingolimod and 428/439
      receiving iDMTs showed that patient retention rate was significantly higher with
      fingolimod than with iDMTs [352 (81.3%) versus 125 (29.2%); 95% confidence
      interval 46.4-57.8%; p < 0.0001]. The most common treatment switch was from iDMT
      to fingolimod for injection-related reasons. Patient satisfaction was greater and
      BVL less with fingolimod than with iDMTs, with no difference in cognitive
      function. Adverse events were consistent with established tolerability profiles
      for each treatment. Conclusions: In RRMS, fingolimod was associated with better
      treatment retention, patient satisfaction and BVL outcomes than iDMTs. Patients
      may persist with iDMTs, but many may switch treatment if permitted. Treatment
      satisfaction fosters adherence, a prerequisite for optimal outcomes.

PMID- 29844795
TI  - Management of colonic diverticular disease in the third millennium: Highlights
      from a symposium held during the United European Gastroenterology Week 2017.
AB  - Diverticulosis is a common anatomical condition, which appears to be age
      dependent. Individuals who develop chronic gastrointestinal symptoms or
      complications are referred to as having diverticular disease. Although the
      diagnosis of this condition can be relatively straightforward, randomized
      controlled trials are scarce and management often follows tradition rather than
      principles of evidence-based medicine. This report deals with the topics
      discussed during a symposium held during the United European Gastroenterology
      Week (Barcelona, October 2017). During the meeting, the role of dysbiosis in the
      pathogenesis of diverticular disease and its treatment were thoroughly discussed,
      by examining the efficacy and mechanisms of action of the currently used drugs.
      Recent studies have shown the presence of dysbiosis in patients with diverticular
      disease and suggest an imbalance in favor of bacteria with pro-inflammatory and
      pathogenetic potential. These microbiota changes correlate with mucosal immune
      activation, mirrored by a marked increase of macrophages in colonic mucosa, both
      in the diverticular region and at distant sites. The low-grade inflammation,
      driven by bacteria-induced immune activation, could be involved in the
      pathophysiology of symptoms. As a consequence, pharmacological approaches
      targeting enteric bacteria (with poorly absorbed antibiotics, like rifaximin, or
      probiotics) or intestinal inflammation (with 5-ASA derivatives or rifaximin) have
      shown capability of controlling symptoms and also preventing complications,
      albeit more research is needed to establish the optimal regimen (daily dose and
      duration) of therapy. Well-designed randomized-controlled trials (RCTs),
      including homogeneous populations of patients, are therefore needed. The future
      of management of many GI diseases, including symptomatic uncomplicated
      diverticular disease, will rely on the so-called 'microbiota-directed therapies'.

PMID- 29844797
TI  - Differential diagnostic value of 64-slice spiral computed tomography in solitary
      pulmonary nodule.
AB  - The present study aimed to evaluate the diagnostic value of 64-slice spiral
      multivariate computed tomography (CT) combined with dynamic contrast-enhanced
      scanning for benign and malignant solitary pulmonary nodules (SPNs). A total of
      93 patients with SPN as diagnosed by CT were included. All these patients were
      subjected to routine and dynamic enhancement CT scanning. After reconstruction,
      the morphological characteristics following dynamic enhancement were analyzed,
      and compared for the benign and malignant SPN cases. The incidences of
      lobulation, spicular sign, pleural indentation and vacuole sign in the malignant
      SPN group were significantly higher compared with the benign SPN group. During
      the dynamic enhancement scanning, the CT values at all the time points for the
      inflammatory and malignant SPN groups were significantly higher than the benign
      SPN group. No significant differences were observed in the dynamic enhancement CT
      values at 30, 60, 90 and 120 sec between the inflammatory, and malignant SPN
      groups. However, in the inflammatory SPN group, the dynamic enhancement CT values
      at 300 and 540 sec were significantly lower than the malignant SPN group.
      Notably, the diagnostic accordance rate for the morphological signs combined with
      dynamic enhancement diagnosis was significantly higher than the morphological
      signs alone. The 64-slice spiral CT morphological signs combined with dynamic
      enhancement detection can be more effective for the differential diagnosis of
      benign and malignant SPN, which may provide potent evidence for the early
      clinical treatment.

PMID- 29844798
TI  - Treatment of Saos-2 osteosarcoma cells with diallyl trisulfide is associated with
      an increase in calreticulin expression.
AB  - Diallyl trisulfide (DATS) is a natural organic sulfur compound that may be
      isolated from garlic and has strong anticancer activity. DATS has been
      demonstrated to upregulate the expression of calreticulin (CRT) in various types
      of human cancers, which is associated with the prognosis of cancer and its
      response to therapy. However, whether DATS has the same effect on human
      osteosarcoma cells is not known. Therefore, in the present study, Saos-2 human
      osteosarcoma cells were cultured with different concentrations of DATS (0, 25, 50
      and 100 umol/l) for 24 h, or with 50 umol/l DATS for different time periods (0,
      12, 24 and 36 h). Reverse transcription-quantitative polymerase chain reaction
      (RT-qPCR), western blotting and immunofluorescent staining were used to detect
      CRT mRNA and protein in the Saos-2 cells. Exposure to DATS changed the morphology
      and inhibited the growth of the Saos-2 cells, and its effects appeared to be
      concentration- and exposure time-dependent. The optimum concentration and
      exposure time of DATS were 50 umol/l and 24 h, respectively. The levels of CRT
      mRNA and protein in the Saos-2 cells were significantly upregulated following
      exposure to DATS. The upregulation of CRT expression by DATS may be a mechanism
      underlying the ability of DATS to inhibit the growth of human osteosarcoma Saos-2
      cells.

PMID- 29844799
TI  - APOE hypermethylation is associated with autism spectrum disorder in a Chinese
      population.
AB  - Abnormal apolipoprotein E (APOE) methylation has been demonstrated to be
      associated with Alzheimer's disease, which may have overlapping mechanisms with
      autism spectrum disorder (ASD). Thus, the purpose of the present study was to
      assess the possible link between APOE methylation and ASD. Genomic DNA was
      extracted from peripheral blood and subjected to a methylation assay. SYBR green
      based quantitative methylation-specific polymerase chain reaction analysis was
      used to measure APOE methylation in 62 pediatric patients with ASD and 73 age
      matched healthy subjects. The APOE methylation in each sample was expressed as a
      percentage of methylation of a reference (PMR). The results indicated that APOE
      methylation in pediatric patients with ASD was significantly higher than that in
      the healthy controls (median PMR, 33 vs. 11%; P=2.36*10-10). Receiver operating
      characteristic curve demonstrated that PMR of 15.4% was the optimal cut-off for
      predicting ASD (area under curve, 0.817; sensitivity, 93.5%; specificity, 72.6%;
      P=2.36*10-10). In summary, the present results indicated that APOE
      hypermethylation in peripheral blood DNA may be used as a diagnostic biomarker
      for ASD.

PMID- 29844800
TI  - Transfer of multiple loci of donor's genes to induce recipient tolerance in organ
      transplantation.
AB  - Donor organ rejection remains a significant problem. The present study aimed to
      assess whether transferring a donor's major histocompatibility complex (MHC)
      genes to the recipient could mitigate rejection in organ transplantation. Seven
      loci of MHC genes from donor mice were amplified and ligated into vectors; the
      vectors either contained one K locus, seven loci or were empty (control). The
      vectors were subsequently injected into the thymus of recipients (in
      heterotransplants, recipient rats received the vector containing one K locus),
      following which donor mouse hearts were transplanted. Following the
      transplantation of allograft and heterograft, electrocardiosignals were viable
      for a significantly longer duration in recipient mice and rats receiving the
      donor histocompatibility-2 complex (H-2)d genes compared with those in controls,
      and in mice that received seven vectors compared with those receiving one vector.
      Mixed lymphocyte cultures containing cells from these recipients proliferated
      significantly less compared with mixed lymphocyte cultures containing controls.
      Also, hearts from H-2d genes-treated recipients demonstrated less lymphocyte
      infiltration and necrosis compared with the control recipient. The present study
      concluded that allograft and heterograft rejection may be mitigated by
      introducing the donor's MHC into the recipient; transferring seven loci has been
      demonstrated to be more effective than transferring one locus.

PMID- 29844801
TI  - Chrysanthemum indicum L. ethanol extract reduces high-fat diet-induced obesity in
      mice.
AB  - The present study was undertaken to investigate the mechanism behind the anti
      obesity effect of the 50% ethanol extract of Chrysanthemum indicum L. flowers
      (CIEE) in a mouse model of high-fat diet (HFD)-induced obesity. Male C57BL/6J
      mice (six mice in each group) were administered CIEE (8, 40 and 200 mg/kg) for 6
      weeks while being fed with a HFD. Garcinia cambogia (GC) was used as the positive
      control and was administered in the same manner as CIEE. Results demonstrated
      that oral administration of CIEE significantly reduced body weight, epididymal
      white adipose tissue (EWAT), liver weight and serum levels of total cholesterol
      and triglyceride (P<0.05). In addition, CIEE reduced serum leptin and increased
      adiponectin levels. CIEE significantly downregulated peroxisome proliferator
      activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein-alpha and
      fatty acid synthase expression levels in EWAT, and upregulated the protein
      expression of PPARalpha in liver tissue of HFD-fed obese mice (P<0.05). These
      results suggested that Chrysanthemum indicum L. flowers may be a potentially
      effective therapeutic agent for obesity and its associated complications.

PMID- 29844802
TI  - Assessment of efficacy of prenatal genetic diagnosis for fragile X syndrome using
      nested PCR.
AB  - Fragile X syndrome (FXS) is the most common inherited cause of intellectual
      disability and the leading monogenic cause of autism spectrum disorder. It has
      previously been demonstrated that prenatal genetic diagnosis is efficient for the
      diagnosis of FXS. The present study investigated the diagnostic effects of nested
      polymerase chain reaction (PCR) for fragile X mental retardation 1 (FMR1) and
      expanded CGG repeats. It was demonstrated that the nested PCR assay rapidly
      measured the multi-copies of the FMR1 gene in individual samples. The nested PCR
      assay detected normal CGG repeat lengths and expanded CGG repeat lengths with a
      low occurrence of false positives. In addition, the nested PCR assay resulted in
      increased sensitivity and specificity for patients with FXS. Furthermore, the
      nested PCR assay identified the mutation and generated conclusive cases for FXS,
      indicating that this assay is beneficial for the diagnosis of FXS patients. In
      conclusion, these outcomes indicate that nested PCR assay is a reliable and
      easier method for diagnosis of FXS, which may be used for the diagnosis of FXS
      patients.

PMID- 29844803
TI  - Sphingosine kinase 1 overexpression is associated with poor prognosis and
      oxaliplatin resistance in hepatocellular carcinoma.
AB  - Sphingosine kinase 1 (SphK1) is a tumor-associated protein overexpressed in
      numerous types of cancer and is involved in the regulation of resistance to
      multiple chemotherapeutic agents. However, the role of SphK1 in the resistance of
      hepatocellular carcinoma (HCC) to oxaliplatin remains unclear. In the present
      study, the transcriptional levels of SphK1 were analyzed in 21 patients with HCC
      and the SphK1 expression levels were identified to be significantly upregulated
      in HCC tissue compared with that in adjacent normal tissue samples (P<0.001).
      High SphK1 expression correlated with shorter overall survival times in patients
      with HCC (P<0.05). Furthermore, SphK1 expression levels and activity were
      analyzed in a series of HCC cell lines and they were both demonstrated to be
      associated with resistance to oxaliplatin. Conversely, the knockdown of SphK1
      protein expression resulted in decreased oxaliplatin resistance in SK-Hep1 and
      HCCLM3 cell lines. In addition, the results of the current study demonstrated
      that the downregulation of SphK1 decreased the levels of phosphorylated AKT
      serine/threonine kinase (Akt) and glycogen synthase kinase-3beta (GSK3beta),
      suggesting that SphK1 promotes oxaliplatin resistance of HCC cells via modulation
      of the Akt/GSK3beta signaling pathway. To the best of our knowledge, the present
      study is the first to report that SphK1 is associated with poor prognosis and
      oxaliplatin resistance in HCC. Thus, the findings of the current study have
      provided a direction for the identification of novel therapeutic targets for the
      treatment of HCC.

PMID- 29844804
TI  - Recombinant adenovirus expressing a dendritic cell-targeted melanoma surface
      antigen for tumor-specific immunotherapy in melanoma mice model.
AB  - Viral vectors represent a potential strategy for the treatment of human malignant
      tumors. Currently, recombinant adenovirus vectors are commonly used as gene
      therapy vehicles, as it possesses a proven safety profile in normal human cells.
      The recombinant adenovirus system has an ability to highly express exogenous
      genes and increase the stability of the carrier, which is only transiently
      expressed in the host cell genome, without integrating. Malignant melanoma cells
      are produced by the skin, and melanocyte tumors that exhibit higher malignant
      degrees lead to earlier transfer and higher mortality. In the present study, a
      recombinant adenovirus (rAd) was generated to express Anti-programmed death-1
      (rAd-Anti-PD-1) and used to investigate the efficacy in melanoma cells and
      tumors. The results demonstrated that B16-F10 cell growth was significantly
      inhibited and the apoptosis incidence rate was markedly promoted following rAd-PD
      1 treatment. The present study demonstrated that the production of alpha and beta
      interferon was increased, which led to the induction of dendritic cell (DCs)
      maturation in rAd-anti-PD-1-treated mice. The present study indicated that rAd
      anti-PD-1 exhibited the ability to generate more cluster of differentiation
      (CD)4+CD8+ T cells and induce a PD-1-specific cytotoxic T lymphocyte through DC
      targeted surface antigens in mice. This resulted in a further enhanced
      recognition of melanoma cells due to DCs being targeted by the rAd-anti-PD-1
      encoded PD-1. Notably, mice treated with the rAd-anti-PD-1-targeted PD-1
      demonstrated an improved protection compared with tumor-bearing mice from the
      challenge group treated with a recombinant gutless adenovirus and Anti-PD-1. In
      conclusion, the present study demonstrated that targeting the melanoma surface
      antigens via the rAd-anti-PD-1-infected tumor cells enhanced the ability of
      recombinant adenovirus to induce a potent tumor-inhibitory effect and antigen
      specific immune response.

PMID- 29844805
TI  - Sparstolonin B improves neurological outcomes following intracerebral hemorrhage
      in mice.
AB  - Inflammation serves an important role in inducing secondary injury following
      intracerebral hemorrhage (ICH). It has been demonstrated that sparstolonin B
      (SsnB) is able to attenuate the lipopolysaccharide-induced inflammatory response
      in sepsis. Mouse ICH models were used to explore the efficacy of SsnB on the ICH
      induced inflammatory response. Mice underwent a working memory version of Morris
      water maze (MWM) test. They underwent 5 successive days of training consisting of
      4 trials each day. The ICH model was established on the last training day. Mice
      were injected intraperitoneally either with vehicle or SsnB once a day for 3
      consecutive days following the establishment of the ICH model. The MWM was used
      to determine the effect of SsnB on short-term memory following ICH. Neurological
      deficit scores and brain water content were measured following the MWM.
      Furthermore, the expression of inflammatory factors and signaling molecules
      downstream of TLR4 were measured. The results demonstrated that 5 mg/kg SsnB
      significantly improved the MWM path and time latency (P<0.05). Furthermore,
      neurological deficit scores were decreased in SsnB-treated mice compared with
      vehicle-treated mice (P<0.01). Brain water content, levels of inflammatory
      cytokines and the expression of inflammation-associated proteins were also
      significantly reduced in the SsnB-treated group (P<0.05). These results indicate
      that SsnB treatment stimulates short-term neurobehavioral recovery and reduces
      neurological deficits and this may inhibit the inflammatory response. Therefore,
      SsnB may attenuate the inflammatory response following ICH.

PMID- 29844806
TI  - Chronic expanding hematoma in the chest: A case report.
AB  - Chronic expanding hematoma (CEH) is a rare disease that is usually present as a
      large solitary pulmonary nodule. CEHs are slow growing, but processes underlying
      their development remain unknown. The present study herein reports the case of a
      76-year-old male patient with CEH and discusses a number of CEH cases published
      in the literature. The majority of these previously described patients were
      Asians. The CEH in the present case was not a successfully resected one, but the
      patient's clinical course provided information concerning the natural history of
      the disease. During the clinical course, the patient underwent several chest
      computed tomography scans. For the present case report, the doubling time and
      volume change of the mass was calculated, which revealed that the lesion had an
      inconstant growth rate and that its onset was between 8.2-11.0 years before the
      patient succumbed to this disease. Accumulation of knowledge about this rare
      disease will help to elucidate it further.

PMID- 29844807
TI  - Role of plasminogen activator inhibitor-1 in the diagnosis and prognosis of
      patients with Parkinson's disease.
AB  - Parkinson's disease is a neurodegenerative disease that frequently results in
      memory disorders, cognitive decline and dementia. Previous studies have reported
      that plasminogen activator inhibitor-1 (PAI-1) serves an important role in
      cardiovascular disease risk, adiposity, insulin resistance and inflammation.
      However, the role of PAI-1 in diagnosis and prognosis of patients with
      Parkinson's disease following deep brain stimulation (DBS) has not reported, to
      the best of our knowledge. Therefore, the purpose of the present study was to
      investigate the clinical significance of PAI-1 in patients with Parkinson's
      disease. Plasma PAI-1 levels were measured in 102 patients with Parkinson's
      disease who underwent DBS. It was demonstrated that plasma PAI-1 levels were
      significantly increased in patients with Parkinson's disease compared with
      healthy individuals (P<0.01). Patients with Parkinson's disease received DBS
      presented significantly improved cognitive competence compared with controls
      (P<0.01). DBS significantly decreased plasma PAI-1 levels in patients with
      Parkinson's disease compared with controls (P<0.05). It was also observed that
      plasma PAI-1 levels were significantly negatively associated with cognitive
      function for patients with Parkinson's disease (P<0.01). In conclusion, these
      findings demonstrated that the degree of Parkinson's disease severity is
      positively associated with circulating levels of plasma PAI-1 levels, which
      suggests that PAI-1 may be a potential diagnostic and prognostic marker for
      patients with Parkinson's disease.

PMID- 29844808
TI  - Assessment of anti-reflux treatment on pulmonary ventilation function and
      inflammatory cytokines in patients with stable chronic obstructive pulmonary
      disease combined with gastroesophageal reflux.
AB  - Compelling evidence has demonstrated that systemic inflammation among patients
      with stable chronic obstructive pulmonary disease (COPD) is linked with increased
      levels of inflammatory cytokines. The aim of the present study was to investigate
      the effects associated with anti-reflux treatment on pulmonary ventilation
      function and inflammatory cytokines in patients with stable COPD and
      gastroesophageal reflux (GER). One hundred and thirty-six stable COPD and GER
      patients were recruited for the study and randomly designated into the routine
      treatment and the anti GER groups. Six months prior to and after treatment,
      pulmonary ventilation function, 6-min walk distance (6MWD) and times of acute
      exacerbation of COPD (AECOPD) were recorded. The levels of inflammatory cytokines
      IL-13, IL-18, transforming growth factor-beta1 (TGF-betal) and tumor necrosis
      factor-alpha (TNF-alpha) in the sputum were detected by ELISA. BODE indexes,
      including body mass index, obstruction, dyspnea and exercise, were analyzed in
      order to evaluate patient prognoses. In comparison with the routine treatment
      group, patients in the anti-GER group displayed improved pulmonary ventilation
      function, increased 6MWD as well as decreases in AECOPD, levels of IL-13, IL-18,
      TGF-betal and TNF-alpha in the sputum and BODE index 6 months after treatment.
      The results obtained suggested a correlation between the BODE indexes after
      treatment and the course of disease as well as the frequency of exacerbation. The
      key findings of the study suggested that conventional treatment combined with
      anti-reflux treatment could effectively improve pulmonary ventilation function,
      while acting to decrease the levels of inflammatory cytokines and improve the
      prognosis of patients with stable COPD along with GER.

PMID- 29844809
TI  - LncRNA BX357664 inhibits cell proliferation and invasion and promotes cell
      apoptosis in human colorectal cancer cells.
AB  - Colorectal cancer represents a great burden for patients worldwide. Long
      noncoding RNA BX357664 is an RNA that was identified by microarray technique in
      renal cell carcinoma. The function of BX357664 in solid tumors remains largely
      unknown. The present study aimed to investigate the expression profile and
      functional role of BX357664 in human colorectal cancer progression. The
      transcription levels of BX357664 were initially examined in vivo and in vitro. An
      overexpression plasmid was constructed in order to examine the effects of
      BX357664 overexpression on cell proliferation, apoptosis, migration and invasion.
      The results demonstrated that BX357664 was significantly downregulated in
      clinical colorectal cancer tissues and cell lines. Overexpression of BX357664
      decreased cell proliferation rates and cell colony formation capacities in HCT116
      and HT-29 cells. Following BX357664 overexpression, HCT116 and HT-29 cells
      exhibited reduced migration and invasion capacities. Would closure was also
      blunted by >50% following overexpression of BX357664 in HCT-116 and HT-29 cells.
      In addition, the cell cycle regulators Cyclin B1, CDC25C and Cyclin D1 as well as
      the mesenchymal marker N-cadherin were downregulated, whereas the epithelial
      marker E-cadherin was upregulated by BX357664 overexpression. Finally, HCT116 and
      HT-29 cell apoptosis was induced and activities of caspase-3 and caspase-9
      increased significantly following BX357664 overexpression. The present data
      suggested that BX257664 negatively regulated cell proliferation and metastasis
      and promoted cell apoptosis in colorectal cancer. These observations provided
      novel evidence that BX357664 might serve as a tumor suppressor and a potential
      therapeutic target in the treatment of colorectal cancer in the clinic.

PMID- 29844810
TI  - miR-204-5p and miR-3065-5p exert antitumor effects on melanoma cells.
AB  - MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma
      compared with melanocytic nevi. This observation prompted a functional study on
      miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor
      suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted in
      a decrease or increase, respectively, in melanoma cell proliferation and colony
      formation. miR-204-5p mimics hindered invasion, whereas miR-204-5p inhibitors
      stimulated cancer cell migration. Modulation of miR-3065-5p led to a decrease in
      melanoma cell proliferation, altered cell cycle distribution and increased
      expression levels of its target genes HIPK1 and ITGA1, possibly due to functional
      modifications identified in these cells. miR-204-5p and miR-3065-5p demonstrated
      antitumor capacities that may need to be taken into account in the development of
      melanoma treatment approaches.

PMID- 29844811
TI  - Oncogene DEK is highly expressed in lung cancerous tissues and positively
      regulates cell proliferation as well as invasion.
AB  - DEK is a protein ubiquitously expressed in multicellular organisms as well as
      certain unicellular organisms. It is associated with the regulation of cell
      proliferation, differentiation, migration, apoptosis, senescence, self-renewal
      and DNA repairing. In tumor cells it is associated with the carcinogenesis
      process, however there have been few previous studies into the expression of DEK
      in lung cancer. In the present study the expression level of DEK mRNA and protein
      was detected in lung cancer tissues and non-cancerous counterparts by performing
      reverse transcription-quantitative polymerase chain reaction and
      immunohistochemical staining. It was revealed that the expression of DEK was
      increased in lung cancer tissues compared with normal tissue. Knock-down and over
      expression of DEK in A549 cells were performed to determine the role of DEK in
      tumor formation. An MTT assay, colony formation assay and Matrigel invasion assay
      demonstrated that DEK positively regulated cell proliferation and invasion. These
      results suggest that DEK is highly expressed in lung cancer tissues and
      positively regulates cell proliferation and invasion.

PMID- 29844812
TI  - Downregulation of RIP140 in triple-negative breast cancer inhibits the growth and
      proliferation of cancer cells.
AB  - The aim of the present study was to investigate the expression of receptor
      interacting protein 140 (RIP140) in triple-negative breast cancer (TNBC), and its
      association with the prognosis of patients with TNBC. A total of 179 patients
      with breast cancer were included in this study, with 41 cases of TNBC and 138
      cases of non-TNBC. Immunohistochemical staining and western blotting were used to
      detect the protein expression of RIP140 in the cancerous and paracancerous
      tissues, revealing that expression of RIP140 was increased in TNBC tissues
      compared with non-TNBC tissues. High expression of RIP140 in breast cancer tissue
      was associated with a poorer survival time than low RIP140 expression. Using
      lentiviral transfection to downregulate RIP140 expression in MDA-MB-231 cells,
      the effects of RIP140 on the growth and proliferation of breast cancer cells was
      analyzed using subcutaneous tumors in BALB/c nude mice. Immunohistochemical
      staining using a Ki-67 antibody in subcutaneous tumor tissue was used to assess
      the proliferation of MDA-MB-231 cells. The short hairpin RNA-mediated
      downregulation of RIP140 in MDA-MB-231 cells suppressed the growth and the
      proliferation of subcutaneous tumors in BALB/c nude mice. Downregulation of
      RIP140 in breast cancer cells may therefore inhibit the growth and the
      proliferation of these cells, and may provide a therapeutic target for TNBC.

PMID- 29844813
TI  - Metastatic lymph node ratio and Lauren classification are independent prognostic
      markers for survival rates of patients with gastric cancer.
AB  - The long-term prognosis for patients with gastric cancer (GC) following radical
      resection remains poor. It is important to identify prognostic markers to predict
      survival. In the present retrospective study, the association between the
      metastatic lymph node ratio (rN) and the Lauren classification on predicting
      overall survival (OS) was investigated. Furthermore, a subgroup analysis was
      performed on the Lauren classification, using rN score as an independent
      prognostic marker. In total, 261 pathologically confirmed patients with GC were
      retrospectively reviewed. Kaplan-Meier curves and Cox's proportional hazards
      modeling were applied to analyze the OS of patients, and were utilized in the
      subgroup analysis. Receiver operating characteristic (ROC) curves were used to
      compare the accuracy of prognosis between the rN score and lymph node staging (N
      stage). The chi2 test was used to analyze the association between the rN score
      and Lauren classification. Univariate survival and multivariate analysis
      demonstrated that the rN score and Lauren classification were significant
      prognostic markers for patients with GC. The ROC analysis confirmed that the rN
      score was more effective than N staging for OS prediction. Subgroup analysis
      indicated that rN was more accurate at predicting OS time in patients with
      diffuse type GC. The rN score and the Lauren classification were independent
      prognostic factors for the OS of patients with GC following radical resection,
      and the rN score was more accurate than the N stage for predicting the prognosis.
      Overall, the rN may be suitable as an independent predictor for OS in patients
      with diffuse type GC.

PMID- 29844814
TI  - Association between circadian gene CLOCK and cisplatin resistance in ovarian
      cancer cells: A preliminary study.
AB  - The present study aimed to observe the expression of circadian gene clock
      circadian regulator (CLOCK) in ovarian cancer cells and the effects of circadian
      gene CLOCK on cis-dichlorodiamine platinum (cisplatin) resistance in ovarian
      cancer cells. The expression of CLOCK mRNA and protein in cisplatin-sensitive
      A2780 and cisplatin-resistant CP70 cells were detected by quantitative polymerase
      chain reaction and western blot assay. Cisplatin-sensitive A2780 and cisplatin
      resistant CP70 cells were treated with different concentrations of cisplatin for
      48 h, and the expression of hCLOCK protein in the two types of cells was detected
      by western blot assay. RNA interference method was used to knock down the
      expression of CLOCK in cisplatin-resistant CP70 cells. Subsequently, the
      cisplatin-resistant CP70 cells were treated with cisplatin. The proliferation of
      cisplatin-resistant CP70 cells was observed following treatment with cisplatin.
      The expression of CLOCK mRNA was significantly higher in cisplatin-resistant CP70
      cells (1.58+/-0.49) compared with cisplatin-sensitive A2780 cells (0.44+/-0.13)
      (P<0.01). Western blot assay results demonstrated that the expression of CLOCK
      protein was significantly greater in the cisplatin-resistant CP70 cells (1.47+/
      0.34) compared with the cisplatin-sensitive A2780 cells (0.48+/-0.15) (P<0.01).
      Following the treatment of A2780 and CP70 cells with cisplatin, CLOCK protein
      expression increased with an increased concentration of cisplatin, in a dose
      dependent manner (P<0.01). Following the knockdown of CLOCK in cisplatin
      resistant CP70 cells by RNA interference, cisplatin treatment was able to
      significantly inhibit the proliferation of cells and induce apoptosis (P<0.01).
      The expression of circadian gene CLOCK in ovarian cancer cells was strongly
      associated with cisplatin resistance. The upregulation of circadian gene CLOCK in
      ovarian cancer cells may reduce its sensitivity to cisplatin treatment.

PMID- 29844815
TI  - Identification of crucial genes associated with esophageal squamous cell
      carcinoma by gene expression profile analysis.
AB  - To uncover the genes associated with the development of esophageal squamous cell
      carcinoma (ESCC), an ESCC microarray dataset was used to identify genes
      differentially expressed between ESCC and normal control tissues. The dataset
      GSE17351 was downloaded from the Gene Expression Omnibus, containing 5 tumor
      esophageal mucosa samples and 5 adjacent normal esophageal mucosa samples from 5
      male patients with ESCC. The differentially expressed genes (DEGs) were
      identified using the Linear Models for Microarray Data R package. Then, a co
      expression network was constructed using the Weighted Correlation Network
      Analysis (WGCNA) package, and co-expression network modules were obtained with a
      hierarchical clustering algorithm. Additionally, functional enrichment analyses
      for DEGs in the top 2 modules with the highest significance were respectively
      conducted using the WGCNA package and the cluster Profiler package. In total, 487
      upregulated and 468 downregulated DEGs were identified. A total of 24 modules
      were obtained from the co-expression network, and the top 2 modules with the
      highest significance, designated as 'blue4' and 'magenta', were further analyzed.
      In the module blue4, DEGs were significantly enriched in a number of Gene
      Ontology terms, including 'spindle organization' [e.g., ubiquitin conjugating
      enzyme E2 C (UBE2C) and SAC3 domain containing 1] and 'cell cycle process' [e.g.,
      UBE2C, minichromosome maintenance complex component 6 (MCM6) and cell division
      cycle 20 (CDC20)]. Furthermore, a number of DEGs (e.g., UBE2C, CDC20 and MCM6)
      were enriched in the 'cell cycle' and 'ubiquitin mediated proteolysis' pathways.
      In the module 'magenta', a number of DEGs [e.g., transferrin receptor (TFRC) and
      TEA domain transcription factor 4 (TEAD4)] were enriched in the primary metabolic
      process and intracellular membrane-bounded organelle. Additionally, 308
      upregulated genes and 215 downregulated genes were differentially expressed in
      the same pattern in another dataset, GSE20347, including UBE2C, CDC20, MCM6,
      TFRC, TEAD4, protein phosphatase 1 regulatory subunit 3C and MAL, T-cell
      differentiation protein. These DEGs may function in the development of ESCC.

PMID- 29844816
TI  - Bcl-2 promotes metastasis through the epithelial-to-mesenchymal transition in the
      BCap37 medullary breast cancer cell line.
AB  - Metastatic breast cancer is one of the major types of cancer in women. However,
      despite being the focus of considerable research efforts, its molecular mechanism
      remains to be fully elucidated. The B-cell lymphoma/leukemia gene-2 (Bcl-2)
      protein is well known for its role in inhibiting programmed cell death/apoptosis.
      However, little is known concerning its function in cell invasion and migration.
      In the present study, cell migration and invasion assays revealed that anti
      apoptotic Bcl-2 protein induced migration and invasion without affecting cell
      proliferation in the BCap37 breast cancer cell line. In addition, it was found
      that the overexpression of Bcl-2 in BCap37 cells increased metastasis to the lung
      in a mouse model. Using western blotting and RT q-PCR analysis, it was
      demonstrated that the overexpression of Bcl-2 inhibited the expression of E
      cadherin, an epithelial marker, whereas it increased the levels of mesenchymal
      markers N-cadherin and vimentin. Therefore, the results suggested that Bcl-2 may
      induce cellular metastasis in breast cancer via the epithelial-to-mesenchymal
      transition.

PMID- 29844817
TI  - Significance of calreticulin as a prognostic factor in endometrial cancer.
AB  - In patients with endometrial cancer, the expression and prognostic significance
      of calreticulin (CRT) remains to be fully elucidated. To investigate the role of
      CRT in endometrial cancer, the present study compared its expression status with
      clinicopathological characteristics and evaluated its prognostic significance.
      The expression of CRT, PKR-like endoplasmic reticulum kinase (PERK),
      phosphorylated eukaryotic initiation factor 2alpha (p-eIF2alpha), and Ki67 were
      assessed by immunohistochemistry and/or western blotting in endometrial cancer
      patients. The association of the expression of CRT, p-eIF2alpha and Ki67 with
      patient survival rate was assessed by Kaplan-Meier and Cox regression analyses.
      Low levels of CRT and an overexpression of Ki67 were significantly associated
      with the stage, histology, and differentiation of the primary surgery without
      doxorubicin (DOX) neoadjuvant chemotherapy (NAC) patient group and were
      significantly correlated with a short progression-free survival and the overall
      survival. A multivariate analysis revealed that CRT and Ki67 expression were
      independent prognostic indicators for endometrioid endometrial cancer. Low CRT
      expression and an overexpression of Ki67 were significantly associated with DOX
      NAC and the histology (P<0.05) pre-NAC and post-NAC in the DOX-NAC patient group.
      Upon treatment of DOX-NAC, CRT, PERK and p-eIF2alpha protein content were
      overexpressed in DOX-sensitive endometrial cancer (P<0.05), whereas there was no
      significant difference in the DOX-resistant group. Low CRT expression in
      endometrial cancer is significantly associated with aggressive progression and
      poor prognosis. CRT may therefore serve as a molecular marker for predicting the
      progression and prognosis in DOX-resistant endometrial cancer patients.

PMID- 29844818
TI  - B-cell lymphoma 2 is associated with advanced tumor grade and clinical stage, and
      reduced overall survival in young Chinese patients with colorectal carcinoma.
AB  - The development of biomarkers that accurately and reliably detect colorectal
      cancer is a promising approach for colorectal cancer screening. Therefore, the
      objective of the present study was to evaluate the protein expression of alpha
      methylacyl-CoA racemase (P504S/AMACR), tumor protein p53 (p53), B-cell lymphoma 2
      (Bcl-2) and Ki-67/mindbomb E3 ubiquitin protein ligase 1 (MIB-1) in a population
      of Chinese patients with colorectal carcinoma. Colorectal tumors with matched
      normal tissue margins were collected from 148 surgical patients, and the
      demographic and clinical characteristics were collected. Immunohistochemical
      staining and western blot analysis of P504S/AMACR, p53, Bcl-2 and Ki-67/MIB-1
      were conducted. Statistical analyses were used to compare protein expression in
      the colorectal tumors and matched normal tissue margins and to identify any
      associations between them and various clinicopathological parameters. Survival
      analyses were performed using the Kaplan-Meier method. In the present study,
      immunohistochemistry and western blot analysis revealed significantly higher
      expression of all four proteins in colorectal tumors compared with matched normal
      tissue margins (P<0.001). Spearman's rank correlation analysis revealed that Bcl
      2 expression was negatively correlated with pathological grade and Tumor-Node
      Metastasis (TNM) stage (-0.827 and -0.388, respectively; P<0.05). Bcl-2
      expression was revealed to be a significant prognostic indicator of colorectal
      carcinoma [relative risk (95% CI), 0.703 (0.552-0.895); P<0.05]. The log-rank
      test revealed a significant association between low Bcl-2 expression and reduced
      overall survival (P=0.039), as well as a significant association between older
      age (>55 years) and reduced overall survival (P<0.001) in Chinese patients with
      colorectal carcinoma. In conclusion, low expression of Bcl-2 is significantly
      correlated with advanced pathological grade and TNM stage and is a prognostic
      indicator of reduced overall survival in young Chinese patients with colorectal
      carcinoma.

PMID- 29844819
TI  - CD63 inhibits the cell migration and invasion ability of tongue squamous cell
      carcinoma.
AB  - The present study evaluated the expression and potential role of CD63 in the
      migration and invasion of tongue squamous cell carcinoma (TSCC) cells.
      Immunohistochemistry (IHC) was used to investigate the association between the
      expression level of CD63 protein and the histological differentiation of samples
      from 40 patients with TSCC and four normal tongue tissue specimens. RNA
      interference (RNAi) and gene transfection technology were used to alter the
      expression of CD63 in TCA8113 cells. The stable silencing and overexpression of
      CD63 in the TCA8113 cell line was used to assess the impact of the CD63
      expression level on the migratory and invasive abilities of TCA8113 cells in a
      wound healing assay and a Transwell invasion assay. The effect of CD63 on the
      expression of matrix metalloproteinase (MMP)-2 and -9 were evaluated by western
      blot analysis. The results of IHC revealed a positive association between the
      CD63 expression level and the histopathological differentiation of TSCC and a
      negative association between the CD63 expression level and lymph node metastasis
      in TSCC. Western blotting revealed that the expressions of MMP-2 and MMP-9 were
      clearly upregulated in CD63-silenced TCA8113 cells but reduced in CD63
      overexpressing TCA8113 cells, compared with the control. The wound-healing speed
      and the number of cells invading Matrigel-coated filters were negatively
      associated with the CD63 expression level. In summary, the results of the present
      study revealed that CD63 may be an inhibitor of TSCC malignancy and lymph node
      metastasis and may have applications in the prediction of prognosis and gene
      therapy for patients of TSCC.

PMID- 29844820
TI  - A report of amelanotic malignant melanoma of the esophagus diagnosed
      appropriately with novel markers: A case report.
AB  - The present case study reported of amelanotic malignant melanoma of the
      esophagus. A 68-year-old man underwent laparoscopic distal gastrectomy for early
      gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a
      protruded lesion lying adjacent to the melanosis area of the esophagus. Histology
      of the biopsy specimen suggested malignancy, but the diagnosis could not be made.
      The patient underwent trans-thoraco-abdominal curative subtotal esophagectomy.
      Immunohistochemical examination of the resected specimen was negative for HBM-45
      and Melan-A. However, immunohistochemical examinations of SOX10 (Sry-related HMg
      Box gene 10) and KBA.62, which are not associated with melanosome, were strongly
      positive, and tyrosinase was notably positive. A diagnosis primary of amelanotic
      malignant melanoma of the esophagus that consisted of only premelanosomes was
      made. The present findings suggest that, in the diagnosis of malignant melanoma,
      SOX10 and KBA.62 may be useful, particularly in diagnosing amelanotic malignant
      melanoma.

PMID- 29844821
TI  - Tumor-derived mesenchymal-stem-cell-secreted IL-6 enhances resistance to
      cisplatin via the STAT3 pathway in breast cancer.
AB  - Cisplatin is used for the treatment of a range of solid malignant tumors;
      however, with prolonged treatment durations, the sensitivity of tumor cells to
      the drug decreases owing to an unclear mechanism of drug resistance. The present
      study aimed to investigate whether breast-cancer-tissue-derived mesenchymal stem
      cells (BC-MSCs) are involved in mediating the effects of cisplatin on breast
      cancer cells, and which component of the BC-MSC conditioned medium (BC-MSC-CM)
      exhibited an anti-apoptotic effect. Cytokines/chemokines in BC-MSC-CM were
      quantified using a Luminex immunoassay, and reverse transcription-quantitative
      polymerase chain reaction analysis detected interleukin-6 (IL-6) levels in MCF-7
      cells following different treatments. MTT and flow cytometry analysis measured
      cell vitality and apoptosis, respectively, and activation of signal transduced
      and activator of transcription 3 (STAT3) was evaluated by western blotting. BC
      MSCs reversed the pro-apoptotic effect of cisplatin and enhanced the
      proliferation of MCF-7 cells more potently than bone-marrow-derived MSCs. Further
      study revealed that BC-MSCs secreted IL-6 to protect MCF-7 cells from apoptosis
      and promote their survival. Neutralizing IL-6 with a specific antibody partially
      inhibited the IL-6/STAT3 signaling pathway and reversed the promoter role of BC
      MSCs in MCF-7 cells. Taken together, the findings of the present study indicated
      that BC-MSCs decreased the level of cisplatin-induced apoptosis in MCF-7 cells by
      activating the IL-6/STAT3 pathway in cancer cells. BC-MSCs, as important cells in
      the tumor microenvironment, have a key role in the treatment of breast cancer.

PMID- 29844822
TI  - Correlation between prostate stem cell antigen gene expression and oral squamous
      cell carcinoma.
AB  - The aetiology of oral squamous cell carcinoma (OSCC) remains unclear. Numerous
      single nucleotide polymorphisms (SNPs) associated with cancer have been
      identified using genome-wide association studies (GWAS). The present study was
      designed to identify common SNPs associated with cancer susceptibility and to
      evaluate their involvement in OSCC. Susceptible loci were identified by analysing
      a cancer GWAS catalogue. A multicentre case-control study using an OSCC and
      control population was performed for selected SNPs. The function of the selected
      locus and its associated gene was explored using a reverse transcription
      polymerase chain reaction, enzyme linked immunosorbent assay and
      immunohistochemistry. The association between genotypes and clinical parameters
      was assessed in 76 patients with OSCC. Rs2294008 located in the prostate stem
      cell antigen gene (PSCA) was selected. It was identified that the rs2294008
      polymorphism was associated with OSCC susceptibility and PSCA may be involved in
      the development, progression and prognosis of OSCC.

PMID- 29844823
TI  - miR-371-5p suppresses the proliferative and migratory capacity of human
      nasopharyngeal carcinoma by targeting BCL2.
AB  - The aim of the present study was to investigate the expression and function of
      microRNA (miR)-371-5p in nasopharyngeal carcinoma (NPC). The levels of miR-371-5p
      were analyzed in nasopharyngeal epithelium tissues, NPC tissues, human NPC cell
      lines and NP69 cells using reverse transcription-quantitative polymerase chain
      reaction analysis. The association between the level of miR-371-5p and
      clinicopathological variables was also investigated. Cell proliferation was
      determined using an MTT assay, and the activities of cell metastasis were
      determined using wound healing and Transwell migration assays. To assess whether
      miR-371-5p can combine with the targeting sequence of B-cell lymphoma 2 (BCL2)
      mRNA or not, a luciferase activity assay was performed. An animal experiment was
      used to examine the effect of miR-371-5p on the development of NPC. The results
      revealed that the expression of miR-371-5p was reduced in NPC samples and NPC
      cells. The level of miR-371-5p was associated with clinical stage and distant
      metastasis in patients with NPC, and was inversely associated with the protein
      level of BCL-2 in NPC tissues. The upregulation of miR-371-5p reduced cell
      growth, migration and invasion, and inhibited carcinoma growth through targeting
      BCL2 mRNA. Taken together, the regulation of miR-371-5p was shown to offer
      potential as a novel treatment approach for NPC.

PMID- 29844824
TI  - Expression patterns of E2F transcription factors and their potential prognostic
      roles in breast cancer.
AB  - E2Fs, as a family of pivotal transcription factors, have been implicated in
      multiple biological functions in human cancer; however, the expression and
      prognostic significance of E2Fs in breast cancer remains unknown. In the present
      study, the mRNA expression patterns of E2Fs in breast cancer were investigated
      with Oncomine and The Cancer Genome Atlas data. Prognostic values of E2Fs for
      patients with breast cancer were determined using the Kaplan-Meier plotter
      database. The results strongly indicated that E2F1, E2F2, E2F3, E2F5, E2F7 and
      E2F8 were overexpressed in patients with breast cancer, whereas E2F4 and E2F6
      exhibited no expression difference between patients with cancer and healthy
      controls. In survival analyses, elevated E2F1, E2F3, E2F5, E2F7 and E2F8
      expression levels were significantly associated with lower overall survival,
      relapse-free survival (RFS), distant metastasis-free survival (DMFS) or post
      progression survival for patients with breast cancer. Furthermore, high
      expression of E2F4 indicated improved RFS but reduced DMFS. Subgroup analyses
      based on four clinicopathological factors further revealed that E2Fs were
      associated with the prognosis of patients with breast cancer in an estrogen
      receptor-, progesterone receptor-, human epidermal growth factor 2- and lymph
      node status-specific manner. These data indicated that E2Fs may serve as
      promising biomarkers and therapeutic targets for breast cancer.

PMID- 29844825
TI  - Bacillus Calmette-Guerin induces rapid gene expression changes in human bladder
      cancer cell lines that may modulate its survival.
AB  - Bacillus Calmette-Guerin (BCG) immunotherapy is the standard therapy for non
      muscle invasive bladder cancer. The aim of the present study was to identify
      genes that are induced in response to BCG immunotherapy, as these may be
      potential biomarkers for the response to clinical therapy. To model clinical
      therapy, human bladder cancer cell lines were incubated with BCG (live or
      lyophilized BCG Connaught) for 2 h. RNA was extracted and evaluated by
      Representational Differential Analysis (RDA) and oligo arrays. Gene expression
      was confirmed by reverse transcription polymerase chain reaction on fresh cell
      lines with differential abilities to internalize BCG. The effect of 2 major BCG
      soluble proteins, antigen 85B (Ag85B) and Mycobacterium protein tyrosine
      phosphatase A (MptpA) and BCG Tice(r) on gene expression was also determined.
      GAPDH and beta-actin, which are normally used as control genes, were upregulated
      by BCG. Therefore, the ribosomal RNA gene ribosomal protein S27a was used to
      normalize gene expression. The genes likely to be induced by BCG internalization
      and soluble factors were: GSTT2, MGST2, CCL20, TNFalpha, CCNE1 and IL10RB. Those
      induced by BCG membrane interactions and/or soluble factors were: MGST1, CXCL6,
      IL12A, CSF2, IL1beta and TOLLIP. MptpA decreased GSTT2 expression, and Ag85B
      increased TNFalpha expression. The two BCG strains significantly increased GSTT2,
      TNFalpha and TOLLIP levels in MGH cells. However, in J82 cells there was a BCG
      strain-dependent difference in TNFalpha expression. An important outcome of the
      present study was the determination that neither GAPDH nor beta-actin were
      suitable control genes for the analysis of BCG-induced gene expression. BCG
      Connaught and Tice(r) induced similar expression levels of genes in bladder
      cancer cell lines. BCG soluble proteins modulated gene expression and therefore
      may affect therapeutic outcomes. The genes identified may be novel biomarkers of
      the response to BCG therapy.

PMID- 29844826
TI  - Decreased expression of USP9X is associated with poor prognosis in Chinese
      pancreatic ductal adenocarcinoma patients.
AB  - The present study aimed to investigate the expression level of ubiquitin specific
      peptidase 9X (USP9X) and its clinical significance in Chinese patients with
      pancreatic ductal adenocarcinoma (PDAC). The mRNA expression levels of USP9X in
      30 paired PDAC tissue samples were examined by reverse transcription-quantitative
      polymerase chain reaction. The protein expression of USP9X was analyzed by
      immunohistochemistry (IHC) in a tissue microarray containing 205 PDAC specimens.
      All analyses were performed by SPSS 20.0 and GraphPad Prism 5.0 software. The
      USP9X mRNA level was significantly decreased in 18/30 (60.0%) PDAC tissue samples
      compared with matched surrounding non-tumor tissue samples. The results of IHC
      revealed that decreased expression of USP9X was inversely associated with liver
      metastasis (P=0.032). Kaplan-Meier survival curves indicated that patients with
      high expression of USP9X presented a longer clinical overall survival time
      (P<0.001). Univariate and multivariate COX regression analysis revealed that
      USP9X protein expression level was a significant, and independent prognostic
      factor for the overall survival rate of patients with PDAC. The results of the
      present study indicate that USP9X may serve as a candidate tumor suppressor and
      prognostic biomarker in PDAC.

PMID- 29844827
TI  - Signaling via the CXCR5/ERK pathway is mediated by CXCL13 in mice with breast
      cancer.
AB  - Breast cancer is the most common cause of cancer-associated mortality and the
      most frequently diagnosed type of cancer in women worldwide. It has been revealed
      that the chemokine C-X-C motif chemokine ligand 13 (CXCL13) serves a pivotal role
      in breast cancer growth and is associated with lymph node metastasis. However, to
      the best of our knowledge, the mechanism by which CXCL13 mediates breast cancer
      growth remains uncharacterized. Female BALB/c mice were used in this study. Tumor
      volume was calculated and changes of gross tumor morphology were observed by
      hematoxylin and eosin staining. The expression of CXCL13, C-X-C motif chemokine
      receptor 5 (CXCR5) and extracellular signaling-related kinase (ERK) mRNA and
      protein expression were detected by reverse transcriptase quantitative-polymerase
      chain reaction and western blot analysis. Simultaneously, the production of
      cytokines [interleukin-1beta (IL-1beta), tumor necrosis factor (TNF) and tumor
      growth factor beta1 (TGF-beta1)] was detected by an ELISA. The CXCL13 inhibitor
      reduced tumor volume and growth, and reduced the mRNA and protein expression
      levels of key members of the CXCR5/ERK signaling pathway: CXCL13, CXCR5 and ERK.
      Furthermore, the detectable concentration of the cytokines IL-1beta and TNF
      decreased following CXCL13 inhibition, whereas the concentration of TGF-beta1 was
      increased. The attenuation of tumor growth resulting from CXCL13 inhibition may
      be associated with the CXCR5/ERK signaling pathway. This study provides a
      theoretical basis for treating breast cancer through CXCL13 inhibition in
      clinical trials.

PMID- 29844828
TI  - Serum peptide expression and treatment responses in patients with advanced non
      small-cell lung cancer.
AB  - Epidermal growth factor receptor (EGFR) mutation is an important predictor for
      response to personalized treatments of patients with advanced non-small-cell lung
      cancer (NSCLC). However its usage is limited due to the difficult of obtaining
      tissue specimens. A novel prediction system using matrix assisted laser
      desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been
      reported to be a perspective tool in European countries to identify patients who
      are likely to benefit from EGFR tyrosine kinase inhibitor (TKI) treatment. In the
      present study, MALDI-TOF MS was used on pretreatment serum samples of patients
      with advanced non-small-cell lung cancer to discriminate the spectra between
      disease control and disease progression groups in one cohort of Chinese patients.
      The candidate features for classification were subsequently validated in a
      blinded fashion in another set of patients. The correlation between plasma EGFR
      mutation status and the intensities of representative spectra for classification
      was evaluated. A total of 103 patients that were treated with EGFR-TKIs were
      included. It was determined that 8 polypeptides peaks were significant different
      between the disease control and disease progression group. A total of 6
      polypeptides were established in the classification algorithm. The sensitivity of
      the algorithm to predict treatment responses was 76.2% (16/21) and the
      specificity was 81.8% (18/22). The accuracy rate of the algorithm was 79.1%
      (34/43). A total of 3 polypeptides were significantly correlated with EGFR
      mutations (P=0.04, P=0.03 and P=0.04, respectively). The present study confirmed
      that MALDI-TOF MS analysis can be used to predict responses to EGFR-TKI treatment
      of the Asian population where the EGFR mutation status differs from the European
      population. Furthermore, the expression intensities of the three polypeptides in
      the classification model were associated with EGFR mutation.

PMID- 29844829
TI  - Utility of intraoperative monitoring with motor-evoked potential during the
      surgical enucleation of peripheral nerve schwannoma.
AB  - Although it is thought that the surgical enucleation of schwannomas can be easily
      performed, certain patients present with postoperative neurological symptoms. The
      present study examined the utility of intraoperative motor-evoked potential (MEP)
      in predicting neurological deficits following the surgical enucleation of
      peripheral nerve schwannoma. The current study included 23 patients and MEP was
      performed using transcranial electrical stimulation. In three cases, the MEP
      decreased to <50% of the preoperative value; however, in two cases that involved
      the peroneal nerve and tibial nerve, results appeared to be false positives
      induced by a tourniquet during surgery. In another case, the MEP was completely
      lost following enucleation of the tumor from the sciatic nerve, which recovered
      to 61% of the original MEP within 10 min. This patient presented with common
      peroneal palsy postoperatively. By contrast, another case involving the lumbar
      nerve root and in which there was reversible postoperative motor loss, the MEP
      did not change intraoperatively. Postoperative neurological deficit occurred in
      22% of patients in the present study, which is similar to that of previous
      reports. The present study also demonstrated that even if a nerve is not
      transected or injured, traction or compression of a peripheral nerve may induce
      ischemia, which can be monitored using MEP. Although MEP alone was not able to
      predict postoperative transient sensory or motor deficits, the combination of MEP
      with other methods of neurological monitoring may improve accuracy and should be
      investigated in future studies.

PMID- 29844830
TI  - DNA damage regulated autophagy modulator 1 recovers the function of apoptosis
      stimulating of p53 protein 2 on inducing apoptotic cell death in Huh7.5 cells.
AB  - Overexpression of apoptosis-stimulating of p53 protein 2 (ASPP2) can induce
      apoptotic cell death in hepatoma cells, which contributes to a killing effect of
      ASPP2 on treating hepatocellular carcinoma (HCC). In the present study, ASPP2
      overexpression failed to induce apoptotic cell death in the HCC Huh7.5 cell line,
      but promoted autophagy development by inhibiting AKT/mTOR pathway. Inhibition of
      autophagy using 3-methyladenosine recovered the function of ASPP2 on inducing
      apoptotic cell death, indicating that ASPP2-induced autophagy has an anti
      apoptotic role in Huh7.5 cells. A previous study demonstrated that ASPP2-induced
      autophagy could induce apoptosis in a CHOP- and DRAM-dependent manner, in which
      CHOP is involved in the initiation of autophagy and DRAM allows autophagy to
      induce apoptosis. In the present study, CHOP and DRAM were not involved in ASPP2
      induced autophagy; however, the induction of DRAM overexpression recovered the
      apoptosis-inducing function of ASPP2, indicating that DRAM overexpression
      switches the role of ASPP2-induced autophagy from anti-apoptotic to pro-apoptotic
      in Huh7.5 cells. Thus, in combination with DRAM, ASPP2 may better perform its pro
      apoptotic role by preventing the occurrence of anti-apoptotic autophagy.

PMID- 29844831
TI  - Identification of key genes and pathways in uterine leiomyosarcoma through
      bioinformatics analysis.
AB  - Uterine leiomyosarcoma (uLMS) is a rare but malignant gynaecological tumour with
      a poor survival outcome. The present study was aimed at identifying the key genes
      and pathways in the development of uLMS through bioinformatics analysis. To
      minimize the frequency of false-positive results of the bioinformatics analysis,
      3 microarrays including GSE764, GSE64763 and GSE68312 were downloaded from Gene
      Expression Omnibus (GEO). Differentially expressed genes (DEGs) were screened out
      using the online tool GEO2R. Then, Gene Ontology and Kyoto Encyclopaedia of Genes
      and Genomes pathway enrichment analyses were performed using the Database for
      Annotation, Visualization and Integrated Discovery. Finally, a protein-protein
      interaction (PPI) network of the DEGs was constructed using Cytoscape, and module
      analysis was conducted using the plug-in MCODE. A total of 95 DEGs including 21
      upregulated genes and 74 downregulated genes were identified. The upregulated
      DEGs were annotated with 'DNA metabolic process', 'nucleobase-containing compound
      biosynthetic process' and 'cellular macromolecule biosynthetic process', while
      the downregulated DEGs were annotated with 'cellular response to chemical
      stimulus', 'movement of cell or subcellular component' and 'response to inorganic
      substances'. The results of the PPI network analysis demonstrated that matrix
      metallopeptidase 9, apolipoprotein E, cyclin E1 and syndecan 1 were the
      predominant upregulated genes in uLMS. Additionally, the genes in the main module
      were enriched in 'proteoglycans in cancer', 'p53 signalling pathway' and
      'extracellular matrix-receptor interaction'. The key genes and pathways
      identified in the present study may provide valuable clues for clarifying the
      molecular mechanism underlying the development of uLMS and demonstrate promise
      for use as diagnostic markers and therapeutic targets.

PMID- 29844832
TI  - Screening for susceptibility genes in hereditary non-polyposis colorectal cancer.
AB  - In the present study, hereditary non-polyposis colorectal cancer (HNPCC)
      susceptibility genes were screened for using whole exome sequencing in 3 HNPCC
      patients from 1 family and using single nucleotide polymorphism (SNP) genotyping
      assays in 96 other colorectal cancer and control samples. Peripheral blood was
      obtained from 3 HNPCC patients from 1 family; the proband and the proband's
      brother and cousin. High-throughput sequencing was performed using whole exome
      capture technology. Sequences were aligned against the HAPMAP, dbSNP130 and 1,000
      Genome Project databases. Reported common variations and synonymous mutations
      were filtered out. Non-synonymous single nucleotide variants in the 3 HNPCC
      patients were integrated and the candidate genes were identified. Finally, SNP
      genotyping was performed for the genes in 96 peripheral blood samples. In total,
      60.4 Gb of data was retrieved from the 3 HNPCC patients using whole exome capture
      technology. Subsequently, according to certain screening criteria, 15 candidate
      genes were identified. Among the 96 samples that had been SNP genotyped, 92 were
      successfully genotyped for 15 gene loci, while genotyping for HTRA1 failed in 4
      sporadic colorectal cancer patient samples. In 12 control subjects and 81
      sporadic colorectal cancer patients, genotypes at 13 loci were wild-type, namely
      DDX20, ZFYVE26, PIK3R3, SLC26A8, ZEB2, TP53INP1, SLC11A1, LRBA, CEBPZ, ETAA1,
      SEMA3G, IFRD2 and FAT1. The CEP290 genotype was mutant in 1 sporadic colorectal
      cancer patient and was wild-type in all other subjects. A total of 5 of the 12
      control subjects and 30 of the 81 sporadic colorectal cancer patients had a
      mutant HTRA1 genotype. In all 3 HNPCC patients, the same mutant genotypes were
      identified at all 15 gene loci. Overall, 13 potential susceptibility genes for
      HNPCC were identified, namely DDX20, ZFYVE26, PIK3R3, SLC26A8, ZEB2, TP53INP1,
      SLC11A1, LRBA, CEBPZ, ETAA1, SEMA3G, IFRD2 and FAT1.

PMID- 29844833
TI  - Expression levels of long non-coding RNA HOXA distal transcript antisense RNA and
      metabotropic glutamate receptor 1 in pancreatic carcinoma, and their prognostic
      values.
AB  - As a type of malignant tumor developed at the pancreas, the prognosis of
      pancreatic carcinoma is usually poor, and >90% patients will sucumb to this
      disease <5 years after diagnosis. Therefore, early detection and treatment of
      this disease are important for improving the prognosis of patients. Long non
      coding RNAs (lncRNAs) have been proven to serve pivotal functions in the
      development and progression of various tumors. The lncRNA HOXA distal transcript
      antisense RNA (HOTTIP), which serves an oncogenic role in different types of
      malignant tumors, has also been reported to be closely correlated with the
      migration and invasion of pancreatic carcinoma. In addition, the metabotropic
      glutamate receptor 1 (mGluR1) is also associated with the progression of various
      types of human cancer; however, its functionality in pancreatic carcinoma is
      largely unknown. In the present study, the expression levels of HOTTIP and mGluR1
      were compared between pancreatic carcinoma and adjacent normal healthy tissues,
      and the correlation between these expression levels was analyzed. The prognostic
      value of HOTTIP and mGluR1 in pancreatic carcinoma was also examined. It was
      observed that the expression levels of HOTTIP and mGluR1 were upregulated in
      pancreatic carcinoma tissues and pancreatic carcinoma cells, while the expression
      of HOTTIP was able to positively affect the expression of mGluR1. In addition,
      high expression levels of HOTTIP were significantly correlated with the tumor
      size and distant metastasis. These data suggested that HOTTIP and mGluR1 may
      potentially serve as biomarkers for the prognosis of pancreatic carcinoma.

PMID- 29844834
TI  - Euchromatic histone lysine methyltransferase 1 regulates cancer development in
      human gastric cancer by regulating E-cadherin.
AB  - Gastric cancer (GC) is among the most aggressive types of cancer and is the
      second leading cause of cancer-associated mortality worldwide. The specific role
      of deregulated expression/activity of histone methyltransferases (HMTs) in GC is
      poorly understood. The present study aimed to explore the possible oncogenic role
      of euchromatic histone lysine methyltransferase 1 (EHMT1) in gastric
      carcinogenesis. It was identified that EHMT1 was highly expressed in GC tissues
      compared with that in adjacent non-tumor tissues, and that EHMT1 expression
      levels were significantly associated with tumor stage and lymph node metastasis.
      Through knockdown of EHMT1 in the BGC-803 cell line, EHMT1 was demonstrated to
      promote a malignant phenotype, and to increase the wound healing, migration and
      invasion abilities of GC cells. Corresponding to these in vitro results,
      knockdown of EHMT1 also inhibited the peritoneal metastasis of GC cells in vivo.
      Furthermore, EHMT1 also regulated the expression of the epithelial-mesenchymal
      transition marker E-cadherin in vitro and in vivo. These results indicate that
      EHMT1 is upregulated in GC and serves an oncogenic role in GC development by
      regulating E-cadherin expression.

PMID- 29844835
TI  - Circulating and tumor-infiltrating myeloid-derived suppressor cells in cervical
      carcinoma patients.
AB  - Myeloid-derived suppressor cells (MDSCs) serve an immunosuppressive role in human
      tumors. Human Lin-/low human leukocyte antigen-antigen D related (HLA-DR-)
      cluster of differentiation (CD)-11b+CD33+ MDSCs are closely linked with tumor
      staging, progression, clinical therapeutic efficacy and prognosis for various
      types of tumors. The present study employed multiparametric flow cytometry to
      measure the proportion of Lin-/lowHLA-DR-CD11b+CD33+ MDSCs in the peripheral
      blood of 105 cervical cancer patients and 50 healthy subjects. The level of MDSC
      was higher in tumor patients than in the normal control group and this was
      closely associated with clinical staging. Further analysis of tumor-infiltrating
      MDSCs was performed in 22 patients. The MDSC proportions in tumor tissue were
      significantly higher than those in the corresponding adjacent tissue. The
      phenotypic characteristics of Lin-/lowHLA-DR-CD11b+CD33+ MDSCs were then
      evaluated and the results revealed that they express high CD13 and CD39, and low
      CD115, CD117, CD124 and programmed cell death ligand 1; they were also devoid of
      CD14, CD15 and CD66b. MDSCs and T-cells from peripheral blood were sorted by flow
      cytometry for co-culture experiments. Lin-/lowHLA-DR-CD11b+CD33+ MDSCs from
      patients significantly inhibited the proliferation of CD4 and CD8 T-cells.
      Furthermore, functional analysis verified that MDSCs from cervical cancer
      patients could inhibit interleukin-2 and interferon-gamma production from T
      cells. In addition, the associations between peripheral circulating MDSCs and
      tumor infiltrating MDSCs, and tumor relapse and metastasis were analyzed. The
      number of peripheral MDSCs and MDSCs in tumor tissue were observed to be
      associated with relapse-free survival. Thus, MDSCs in the peripheral blood and
      tumors of cervical cancer patients have a significant immunosuppressive effect,
      and are associated with cervical cancer staging and metastasis. These results
      suggest that targeting MDSCs may increase antitumor immunity and increase the
      efficacy of cervical cancer therapies.

PMID- 29844836
TI  - Evaluation of efficacy and safety of minimally invasive segmentectomy in the
      treatment of lung cancer.
AB  - The aim of the study was to investigate the efficacy and safety of minimally
      invasive segmentectomy in the treatment of lung cancer. A total of 86 lung cancer
      patients in early stage were selected for the treatment between May, 2010 and
      December, 2010. The patients were randomly divided into the control (n=43) and
      observation (n=43) groups. Patients in the control group received conventional
      thoracotomy as treatment, while thoracoscopic segmentectomy was performed for
      patients in the observation group. Factors including intraoperative bleeding
      amount, number of dissected lymph nodes, surgery duration, postoperative
      intubation time and length of stay (LOS) were compared between the two groups. A
      visual analogue scale was used for comparison of the postoperative incisional
      pain experienced by patients in the two groups. The incidence rate of
      postoperative complications of patients in the two groups was observed. We also
      assayed variations in the levels of serum inflammatory factors C-reaction protein
      (CRP), interleukin (IL) -6 and -10 of patients prior to operation and on the 3rd,
      5th and 7th days and after operation via ELISA, and on the 7th day after
      operation, we determined the pulmonary function of patients. During the 5-year
      follow-up, the recurrence and survival rate of patients in the two groups were
      observed. In the observation group, the intraoperative bleeding amount of
      patients was significantly lower than that in the control group, and the surgery
      duration, postoperative intubation time and LOS were all shorter than those in
      the control group (P<0.05). By contrast, no significant difference was detected
      in a comparison of the number of dissected lymph nodes of patients between the
      two groups (P>0.05). Additionally, in the observation group, patients suffered
      less pain after operation than those in the control group (P<0.05), and on the
      3rd, 5th and 7th days after operation, the levels of CRP, IL-6 and -10 in the
      observation group were significantly lower than those in the control group
      (P<0.05). After operation, the incidence rate of complications in the observation
      group was significantly lower than that in the control group (P<0.05), and the
      recovery in pulmonary function after operation was superior to that in the
      control group (P<0.05). In addition, the 5-year survival rate of patients in the
      observation group was significantly higher than that in the control group, and
      the recurrence rate was significantly lower than that in the control group
      (P<0.05). Minimally invasive segmentectomy shows better efficacy in the treatment
      of lung cancer at early stage than the conventional thoracotomy. In addition to
      the high safety during surgery, this technique can lower the incidence rate of
      postoperative complications, protect the pulmonary function, increase the
      survival rate and decrease the recurrence rate, which shows great value in
      clinical practice.

PMID- 29844837
TI  - The mechanism of miR-143 inducing apoptosis of liver carcinoma cells through
      regulation of the NF-kappaB pathway.
AB  - Primary hepatic carcinoma is a common malignant tumor with poor treatment
      efficacy. The effect and mechanism of miR-143 in apoptosis of liver carcinoma
      cells were investigated in the present study. In vitro transfection of liver
      carcinoma SMMC-7721 cells was performed using artificially synthesized miR-143
      mimics. The proliferation of liver carcinoma cells that were treated was detected
      by MTT assay. Liver carcinoma cells were then stained using the Annexin V-FITC/PI
      method, and the apoptosis of stained liver carcinoma cells was measured using a
      flow cytometer. The relative mRNA expression of NF-kappaB p65 in the intervention
      and control groups was assayed using reverse transcription-quantitative
      polymerase chain reaction, and the protein expression of NF-kappaB p65 was
      detected using western blot analysis. The results showed that, in the
      intervention group, the proliferation rate of cells transfected using miR-143
      mimics was significantly lower than that in the control group, the number of
      apoptotic SMMC-7721 cells in the intervention group increased, and the protein
      expression of NF-kappaB p65 was decreased. Thus, miR-143 may downregulate the
      protein expression of NF-kappaB p65, thereby triggering the NF-kappaB signaling
      transduction pathway inducing apoptosis of liver carcinoma cells.

PMID- 29844838
TI  - Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy
      sensitivity.
AB  - The expression of high mobility group box 1 (HMGB1), breast cancer susceptibility
      gene 1 (BRCA1) and P62 in ovarian cancer was investigated to explore its
      association with chemotherapy sensitivity in ovarian cancer patients. Tumor
      tissues and para-carcinoma normal tissues of 60 ovarian cancer patients
      hospitalized in Department of Surgery in Dongying Hospital from June, 2012 to
      June, 2015 were collected. Reverse transcription-quantitative polymerase chain
      reaction (RT-qPCR) was used to detect the mRNA expression levels of HMGB1, BRCA1
      and P62 in tumor and para-carcinoma normal tissues. Moreover,
      immunohistochemistry was used to detect the protein expression of HMGB1, BRCA1
      and P62 in tumor tissues and para-carcinoma normal tissues. The cancer tissue
      specimens were divided into the chemotherapy resistance group and sensitivity
      group through the in vitro resin droplet experiment to analyze the association of
      the expression of HMGB1, BRCA1 and P62 in epithelial ovarian cancer with
      chemotherapy resistance of patients. The RT-qPCR results showed that the
      expression of HMGB1, BRCA1 and P62 in ovarian cancer tissues at the mRNA level
      was significantly higher than that in para-carcinoma normal tissues.
      Immunohistochemical results showed that the positive expression levels of HMGB1,
      BRCA1 and P62 in ovarian carcinoma tissue were 61.67% (37/60), 76.33% (47/60) and
      71.67% (43/60), respectively, while the positive expression levels of HMGB1,
      BRCA1 and P62 in para-carcinoma normal tissues were 13.33% (8/60), 8.33% (5/60)
      and 11.67% (7/60), respectively, and the differences were statistically
      significant (P<0.05). In vitro resin droplet experiment revealed that 38 out of
      60 ovarian cancer patients were drug resistant and 22 patients were sensitive to
      the therapy. The analysis of the association with chemotherapy sensitivity
      revealed that the positive expression of HMGB1, BRCA1 and P62 was associated with
      the drug resistance of ovarian cancer patients. The positive expression of HMGB1,
      BRCA1 and P62 was associated with chemotherapy sensitivity of ovarian cancer
      patients. Therefore, HMGB1, BRCA1 and P62 may be molecular markers for the
      prediction of chemotherapy sensitivity of ovarian cancer patients.

PMID- 29844839
TI  - Evaluation of latent membrane protein 1 and microRNA-155 for the prognostic
      prediction of diffuse large B cell lymphoma.
AB  - Diffuse large B cell lymphoma (DLBCL) has previously been demonstrated to
      contribute to the mortality of lymphoma with various aggressive features. The
      prognostic role of the biomarkers latent membrane protein (LMP) 1 and microRNA
      (miR)-155 in DLBCL remain controversial. The present study primarily aimed to
      assess the effect of LMP1 and miR-155 on the survival of DLBCL patients, and
      additionally evaluate the clinical features to observe their influence on
      outcomes, compared with previous studies. Formalin-fixed and paraffin-embedded
      samples were collected from our center between May 2010 and December 2011.
      Microarray analysis, immunohistochemical analysis and reverse transcription
      quantitative polymerase chain reaction were used to evaluate the expression of
      LMP1 and miR-155. The association between biomarkers or clinical features and
      patient outcomes was assessed using the log-rank statistical test, Cox
      proportional hazard model and Kaplan-Meier method. SPSS software was used to
      statistically analyze the data. A total of 82 patients were included in the
      present study. The results demonstrated that high expression of LMP1 and miR-155
      may be associated with a poor progression-free survival rate, while a high
      International Prognostic Index score and high expression of LMP1 may be
      associated with a poor overall survival rate. These results indicated that LMP1
      and miR-155 may be novel and reliable biomarkers for the prognostic prediction of
      lymphoma, and will potentially be analyzed in the future to evaluate patient
      prognosis.

PMID- 29844840
TI  - Comprehensive identification of microRNA arm selection preference in lung cancer:
      miR-324-5p and -3p serve oncogenic functions in lung cancer.
AB  - MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the
      dysregulation of tumor suppressors and oncogenes during lung cancer progression.
      Selection of the 5p and 3p arms of miRNA is a mechanism that improves the
      modulation of miRNA biological functions and complicates the regulatory network
      in human types of cancer. However, the involvement of arm selection preference of
      miRNA in lung cancer remains unclear. In the present study, changes in miRNA arm
      selection preference were comprehensively identified in lung cancer and
      corresponding adjacent normal tissues by analyzing The Cancer Genome Atlas. Arm
      selection was revealed to be consistent in the majority of miRNAs in lung cancer.
      Only a few miRNAs had significantly altered arm selection preference in lung
      cancer. Among these, the biological functions of the individual arms of miR-324
      were investigated further. The data revealed that miR-324-5p and -3p were
      significantly overexpressed in lung cancer cells. Ectopic expression of miR-324
      5p significantly promoted cell proliferation and invasion in lung cancer cells,
      while miR-324-3p overexpression significantly increased cell proliferation but
      did not alter the invasion of lung cancer cells. In conclusion, the arm selection
      preference of miRNA may be an additional mechanism through which biological
      functions are modulated. The results of the present study provide a novel insight
      into the underlying mechanisms of lung cancer and may direct research into future
      therapies.

PMID- 29844841
TI  - Expression of serum Hsa-miR-93 in uterine cancer and its clinical significance.
AB  - The aim of the study was to investigate the differential expression of micro
      ribonucleic acid (miRNA)-93 in serum of patients with uterine cancer, and to
      explore the clinical significance. A total of 176 patients with uterine cancer
      who received surgery from May, 2009 to January, 2011 in the Department of
      Oncology of Hubei Cancer Hospital were selected. At the same time, 100 healthy
      individuals selected from the Physical Examination Center of Hubei Cancer
      Hospital comprised the control group. Mean age of patients was 55+/-11 years, and
      of the healthy individuals in the control group was 53+/-9 years. Blood was
      extracted from each participant to prepare serum samples. Change in the
      expression of serum miRNA-93 was detected by reverse transcription-polymerase
      chain reaction (RT-PCR), and the correlation between the expression of miRNA-93
      and clinicopathological features of uterine cancer was analyzed. Expression level
      of miRNA-93 in serum of patients with uterine cancer was significantly lower than
      that in the healthy controls (P<0.05). Expression level of miRNA-93 was
      significantly correlated with pathological staging and lymph node metastasis
      (P<0.05). Receiver operating characteristic curve analysis showed that the area
      under curve was 0.781 and 95% confidence interval was 0.724-0.842. Survival rate
      of the high miRNA-93 expression group was significantly higher than that in the
      low miRNA-93 expression group (P=0.036). These results indicate that change in
      the expression of miRNA-93 is related to the occurrence of uterine cancer, and
      its decreased expression level suggests tumorigenesis.

PMID- 29844842
TI  - Role of hepcidin and iron metabolism in the onset of prostate cancer.
AB  - The present study aimed to understand the roles of hepcidin and iron metabolism
      in the onset of prostate cancer. The prostate cancer LNCap, PC3 and DU145 cell
      lines were transfected with small interfering RNA (siRNA) targeting hepcidin to
      knockdown hepcidin expression in LNCap, PC3 and DU145 cells. The expression
      levels of hepcidin in prostate cancer and normal prostate RWPE-1cells were
      detected by western blot analysis. Exogenous hepcidin was added into the hepcidin
      silenced cell lines. Intracellular iron levels were detected using a fluorescence
      assay, and the proliferative and migratory capacities of cells were detected
      using the MTT and wound-healing assays, respectively. The apoptotic rate was
      measured using flow cytometry, and changes in the expression of the iron-export
      protein ferroportin on the cell membrane were detected by western blot analysis.
      Hepcidin expression in prostate cancer cells was significantly higher than that
      of normal prostate cells (P<0.05). Furthermore, the iron levels of hepcidin
      silenced cells (hepcidin-ve groups) were significantly lower than those in the
      cells treated with exogenous hepcidin (hepcidin+ve groups) (P<0.05). The
      proliferative capacity of the hepcidin+ve cells significantly exceeded those of
      the hepcidin-ve groups (P<0.05) and increased over time. In the wound-healing
      assay, the number of hepcidin+ve cells present within the scratch sites increased
      compared with hepcidin-ve cells, indicating a higher migration rate.
      Additionally, the expression of ferroportin in the hepcidin-ve groups
      significantly exceeded that in the hepcidin+ve groups (P<0.05). Hepcidin is
      involved in the onset of prostate cancer, most likely by reducing ferroportin
      expression and increasing intracellular iron levels to enhance the proliferation,
      migration and anti-apoptotic capacities of cancer cells.

PMID- 29844843
TI  - Clinical significance of androgen receptor expression in triple negative breast
      cancer-an immunohistochemistry study.
AB  - Androgen receptor (AR) is closely associated with the occurrence and progression
      of breast cancer; however, the clinical significance of it in triple negative
      breast cancer (TNBC) has been controversial. There is a limited amount of
      research regarding the effect of neoadjuvant chemotherapy on AR expression. By
      examining the expression of AR in patients with TNBC, the aim of the present
      study is to explore the clinical significance of AR and provide evidence for AR
      directed treatment in TNBC. A total of 188 patients with primary TNBC with
      complete medical records were included in this retrospective study. Tumor
      sections from 41 patients (21.8%) were positive for AR, which was more often
      detected in small tumors (P=0.042) and cases with no lymph node involvement
      (P=0.032). Among them, 102 were treated with neoadjuvant chemotherapy (NAC). A
      total of 17 patients (16.7%) exhibited pathological complete response. However,
      the patient response was irrelevant to AR expression. Matched pathological
      tissues before and after NAC were collected for 49 cases, suggesting an
      enrichment of AR-expressing tumors following chemotherapy (P=0.008). Further
      analysis indicated that AR expression had no correlation with the disease-free
      and overall survival of patients with general TNBC; rather, it predicted a poor
      survival of the patients with stage III TNBC in comparison with those at earlier
      stages (P=0.035). AR expression occurs more often in small TNBC tumors or in
      cases with no lymph node metastasis. It is associated with a poor prognosis of
      the patients with advanced stages of tumors.

PMID- 29844844
TI  - Patients' Main Concerns About Having a Sibling Stem Cell Donor - A Grounded
      Theory Study.
AB  - Background: There is limited knowledge about the perspective of patients
      undergoing allogeneic haematopoietic stem cell transplantation (HSCT) about
      having a sibling as donor. It is essential to understand the main concerns of
      stem cell recipients in order to enable nurses to provide person-centred care.
      Objectives: The study aim was to explore patients' main concerns about having a
      sibling stem cell donor and how the patients handle them, from immediately before
      until one year after transplantation. Methods: Twenty-eight interviews were
      performed prospectively during one year with ten adult sibling stem cell
      recipients with a mean age of 52 years (range 19-68 years). The interviews were
      analyzed by the Grounded Theory method. Results: The core category Recompensation
      summarises the process in the generated grounded theory including the three main
      categories; Invest, Compensate and Celebrate. Recompensation is defined as a
      lasting compensation given by the recipient to the sibling donor for the loss or
      harm suffered or effort made. The sense of having to reward, protect, appreciate,
      maintain peace and work on the relationship with the sibling donor at the same
      time as having to accept a serious illness, cope with their situation and promote
      their own recovery is strenuous for the recipients. Conclusion: The main concern
      for stem cell recipients during their first post-transplant year is to
      recompensate the sibling donor by investing, compensating and celebrating
      her/him. Although there is a positive aspect of recompensation, it can also imply
      pressure and guilt.

PMID- 29844845
TI  - Electronic Monitoring Systems to Assess Urinary Incontinence: A Health Technology
      Assessment.
AB  - Background: Urinary incontinence is involuntary leakage of urine and can affect
      people of all ages. Incidence rises as people age, often because of reduced
      mobility or conditions affecting the nervous system, such as dementia and stroke.
      Urinary incontinence can be a distressing condition and can harm a person's
      physical, financial, social, and emotional well-being. People with urinary
      incontinence are susceptible to skin irritation, pressure sores, and urinary
      tract infections. Urinary incontinence is also associated with an increased risk
      of falls in older adults.This health technology assessment examined the
      effectiveness of, budget impact of, and patient values and preferences about
      electronic monitoring systems to assess urinary incontinence for residents of
      long-term care homes or geriatric hospital inpatients with complex conditions.
      Methods: A clinical evidence review of the published clinical literature was
      conducted to June 9, 2017. Critical appraisal of the clinical evidence included
      assessment of risk of bias and the Grading of Recommendations Assessment,
      Development, and Evaluation (GRADE) Working Group criteria to reflect the
      certainty of the evidence.We calculated the funding required for an electronic
      urinary incontinence monitoring system in the first year of implementation (when
      facilities would buy the systems) and in subsequent years.We interviewed six
      people with urinary incontinence and two caregivers, who described ways urinary
      incontinence affected daily life. Results: We included one observational study in
      the clinical review. Most of the 31 participants in the observational study were
      female (78%) and required high levels of care, primarily because of cognitive
      impairment. The quality of evidence for all outcomes was very low owing to
      potential risk of bias and indirectness. We are consequently uncertain about how
      electronic monitoring systems affect management of urinary incontinence.For
      patients living in long-term care homes who are eligible for the technology, we
      estimated that an electronic monitoring system to assess urinary incontinence
      would cost $6.4 million in the first year of implementation and $1.6 million in
      subsequent years.Patients said urinary incontinence reduced their independence
      and social life and adversely affected their quality of life. Incontinence made
      them embarrassed and reduced their self-esteem. Several respondents mentioned how
      expensive supplies to manage incontinence were. Conclusions: The effectiveness of
      using the electronic monitoring system to assess urinary incontinence is
      uncertain because of the very low quality of the evidence. Introducing electronic
      monitoring systems would result in incremental costs, and there would be savings
      only if the systems substantially reduced incontinence.

PMID- 29844846
TI  - Toward Sclera-Force-Based Robotic Assistance for Safe Micromanipulation in
      Vitreoretinal Surgery.
AB  - In vitreoretinal surgery instruments are inserted through the sclera to perform
      precise surgical maneuvers inside the eyeball, which exceeds typical human
      capabilities. Robotic assistance can enhance the skills of a novice surgeon,
      provide guidance during tool manipulation based on the desired behavior defined
      by expert surgeons' maneuvers, and consequently improve the surgical outcome.
      This paper presents an experimental study characterizing the safe/desired
      magnitude of forces between the surgical instrument and the sclera insertion port
      as a function of the tool insertion depth. We explore two types of regressions, a
      polynomial and a sum of sines fit, to describe the observed user behavior during
      our one-user pilot study, based on which a variable admittance control scheme can
      be implemented to robotically guide other users towards this desired behavior for
      a safe operation.

PMID- 29844847
TI  - Sinecatechins Ointment, 15% for the Treatment of External Genital and Perianal
      Warts: Proceedings of an Expert Panel Roundtable Meeting.

PMID- 29844848
TI  - Safe Sleep Practices of Kansas Birthing Hospitals.
AB  - Background: Sleep-related death is tied with congenital anomalies as the leading
      cause of infant mortality in Kansas, and external risk factors are present in 83%
      of these deaths. Hospitals can impact caregiver intentions to follow risk
      reduction strategies. This project assessed the current practices and policies of
      Kansas hospitals with regard to safe sleep. Methods: A cross-sectional survey of
      existing safe sleep practices and policies in Kansas hospitals was performed.
      Hospitals were categorized based on reported delivery volume and data were
      compared across hospital sizes. Results: Thirty-one of 73 (42%) contacted
      hospitals responded. Individual survey respondents represented various hospital
      departments including newborn/well-baby (68%), neonatal intensive care unit (3%)
      and other non-nursery departments or administration (29%). Fifty-eight percent of
      respondents reported staff were trained on infant safe sleep; 44% of these held
      trainings annually. High volume hospitals tended to have more annual training
      than low or mid volume birth hospitals. Thirty-nine percent reported a safe sleep
      policy, though most of these (67%) reported never auditing compliance. The top
      barrier to safe sleep education, regardless of delivery volume, was conflicting
      patient and family member beliefs. Conclusions: Hospital promotion of infant safe
      sleep is being conducted in Kansas to varying degrees. High and mid volume birth
      hospitals may need to work more on formal auditing of safe sleep practices, while
      low volume hospitals may need more staff training. Low volume hospitals also may
      benefit from access to additional caregiver education materials. Finally, it is
      important to note hospitals should not be solely responsible for safe sleep
      education.

PMID- 29844849
TI  - Arcanobacterium Brain Abscesses, Subdural Empyema, and Bacteremia Complicating
      Epstein-Barr Virus Mononucleosis.

PMID- 29844850
TI  - Transgender Competent Provider: Identifying Transgender Health Needs, Health
      Disparities, and Health Coverage.

PMID- 29844851
TI  - The Increased Vulnerability of Refugee Population to Mental Health Disorders.

PMID- 29844852
TI  - qNeck Trauma and Extra-tracheal Intubation.

PMID- 29844853
TI  - Strongyloides Duodenitis in an Immunosuppressed Patient with Lupus Nephritis.

PMID- 29844854
TI  - Clinical epidemiology of chronic viral hepatitis B: A Tuscany real-word large
      scale cohort study.
AB  - AIM: To build a regional database of chronic patients to define the clinical
      epidemiology of hepatitis B virus (HBV)-infected patients in the Tuscan public
      health care system. METHODS: This study used a cross-sectional cohort design. We
      evaluated chronic viral hepatitis patients with HBV referred to the outpatient
      services of 16 hospital units. Information in the case report forms included main
      demographic data, blood chemistry data, viral hepatitis markers, instrumental
      evaluations, and eligibility for treatment or ongoing therapy and liver
      transplantation. RESULTS: Of 4015 chronic viral hepatitis patients, 1096 (27.3%)
      were HBV infected. The case report form was correctly completed for only 833
      patients (64% males, 36% females; mean age 50.1 +/- 15.4). Of these HBV-infected
      patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and
      1% American. Stratifying patients by age and nationality, we found that 21.7% of
      HBV-infected patients were aged < 34 years (only 2.8% were Italian). The most
      represented routes of transmission were nosocomial/dental procedures (23%),
      mother-to-child (17%) and sexual transmission (12%). The most represented HBV
      genotypes were D (72%) and A (14%). Of the patients, 24.7% of patients were HBeAg
      positive, and 75.3% were HBeAg negative. Of the HBV patients 7% were anti-HDV
      positive. In the whole cohort, 26.9% were cirrhotic (35.8% aged < 45 years), and
      47% were eligible for or currently undergoing treatment, of whom 41.9 % were
      cirrhotic. CONCLUSION: Only 27.3% of chronic viral hepatitis patients were HBV
      infected. Our results provide evidence of HBV infection in people aged < 34
      years, especially in the foreign population not protected by vaccination. In our
      cohort of patients, liver cirrhosis was also found in young adults.

PMID- 29844855
TI  - Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center
      experience.
AB  - AIM: To characterize isolated non-obstructive sinusoidal dilatation (SD) by
      identifying associated conditions, laboratory findings, and histological
      patterns. METHODS: Retrospectively reviewed 491 patients with SD between 1995 and
      2015. Patients with obstruction at the level of the small/large hepatic veins,
      portal veins, or right-sided heart failure were excluded along with history of
      cirrhosis, hepatic malignancy, liver transplant, or absence of
      electrocardiogram/cardiac echocardiogram. Liver histology was reviewed for extent
      of SD, fibrosis, red blood cell extravasation, nodular regenerative hyperplasia,
      hepatic peliosis, and hepatocellular plate atrophy (HPA). RESULTS: We identified
      88 patients with non-obstructive SD. Inflammatory conditions (32%) were the most
      common cause. The most common pattern of liver abnormalities was cholestatic
      (76%). Majority (78%) had localized SD to Zone III. Medication-related SD had
      higher proportion of portal hypertension (53%), ascites (58%), and median AST
      (113 U/L) and ALT (90 U/L) levels. Nineteen patients in our study died within one
      year after diagnosis of SD, majority from complications related to underlying
      diseases. CONCLUSION: Significant proportion of SD and HPA exist without impaired
      hepatic venous outflow. Isolated SD on liver biopsy, in the absence of congestive
      hepatopathy, requires further evaluation and portal hypertension should be rule
      out.

PMID- 29844856
TI  - Galphao (GNAO1) encephalopathies: plasma membrane vs. Golgi functions.

PMID- 29844857
TI  - A clinical trial on the consistency of bilateral testicular tissue histopathology
      and Johnsen score: single side or bilateral side biopsy?
AB  - To evaluate and compare left and right testicular tissue histopathology and
      Johnsen score, and to investigate the necessity for bilateral testicular biopsy.
      We recruited180 patients with non-obstructiveazoospermia (NOA) on testicular
      biopsy who had undergonetesticular sperm aspiration (TESA). Pathological sections
      of testicular tissue were diagnosed by specially-assigned doctors, who evaluated
      pathological findings, determined the Johnsen score and confirmed for the
      presence or absence of sperm. Sperm positive rates for left and right testicular
      histopathology were 55.0% and 51.7% respectively, and the proportion of Johnsen
      scores>=8 for left and right testes were 53.3% and 50.0%, respectively. Cohen
      kappa values revealed that the identification of sperm in bilateral testicular
      samples was not consistent and was related to random effects; Optimized cut-off
      value for bilateral testicular volume was 11ml (Johnsen score >=8), and optimized
      cut-off values of E2 on left and right testes were 144.5pmol/L and 133.5 pmol/L
      (Johnsen score<=7). However, age, serum prolactin (PRL), follicle stimulating
      hormone (FSH), luteinizing hormone (LH) and total testosterone (TT) levels were
      not accurate predictors for the existence of testicular sperm. There was
      nostatistical significance between left and right testicular histopathology in
      terms of sperm positive rates or Johnsen score; the Johnsen score were caused
      entirely by random effects and a score from one side could not represent the
      other side. Therefore, we recommend that both testes need to undergo surgery when
      NOA patients undergo testicular biopsy or sperm retrieval.

PMID- 29844858
TI  - Genetic polymorphism of SLC31A1 is associated with clinical outcomes of platinum
      based chemotherapy in non-small-cell lung cancer patients through modulating
      microRNA-mediated regulation.
AB  - SLC31A1 is the major transporter for platinum drug intake, its expression
      correlates with drug disposition and response. In 1004 Chinese NSCLC patients
      with platinum-based chemotherapy, we investigated the association between SLC31A1
      polymorphisms and clinical outcomes. Heterozygotes of rs10759637 at 3'UTR was
      associated with severe thrombocytopenia (odds ratio [OR]: 2.69; P = 0.012) and
      shorter overall survival (hazard ratio [HR]: 1.24; P = 0.005). Variant homozygote
      of rs2233914 was correlated with longer overall survival (hazard ratio [HR]:
      0.73; P = 0.008). Haplotype and diplotype of these linked SNPs were associated
      with hematologic toxicities. In stratification analyses, rs10759637 and rs2233914
      consistently correlated with overall survival in specific subgroups such as men,
      smoker, patients older than 58 years, or with ECOG PS 0-1, or with squamous cell
      carcinoma. rs10759637 could change the local structure of 3'UTR harboring
      putative binding sites for hsa-miR-29, whose transfection into 16HBE cells
      resulted in remarkable suppression of gene expression. The rs10759637 variant
      significantly correlated with lowered luciferase activity in reporter assays and
      decreased expression of SLC31A1 transcript in tumorous tissues. The study thereby
      identified functional polymorphism of SLC31A1 that modulates miRNA-3'UTR
      interaction and gene expression as potential pharmacogenetic biomarker for
      clinical outcomes of platinum-based chemotherapy in NSCLC patients.

PMID- 29844859
TI  - Oridonin inhibits aberrant AKT activation in breast cancer.
AB  - Aberrant activation of phosphatidylinosito-4,5-bisphosphate 3-kinase/protein
      kinase B (PI3K/AKT) signaling in cancer has led to pursuit of inhibitors for
      targeting this pathway. However, inhibitors of PI3K and AKT have failed to yield
      efficacious results without adverse effects. Here, we screened a library
      containing 441 authenticated traditional chinese medicine (TCM) plant extracts by
      examining their effect on cell viability of a human mammary epithelial cell line
      HMEC-PIK3CAH1047R, which expresses mutant PIK3CAH1047R and has constitutively
      active AKT signaling. We found that Oridonin, an extract from Rabdosia rubescens,
      reduced cell viability to the greatest extent. Oridonin binds to AKT1 and
      potentially functions as an ATP-competitive AKT inhibitor. Importantly, Oridonin
      selectively impaired tumor growth of human breast cancer cells with
      hyperactivation of PI3K/AKT signaling. Moreover, Oridonin prevented the
      initiation of mouse mammary tumors driven by PIK3CAH1047R. Our results suggest
      that Oridonin may serve as a potent and durable therapeutic agent for the
      treatment of breast cancers with hyperactivation of PI3K/AKT signaling.

PMID- 29844860
TI  - Phase I dose-escalation study of F50067, a humanized anti-CXCR4 monoclonal
      antibody alone and in combination with lenalidomide and low-dose dexamethasone,
      in relapsed or refractory multiple myeloma.
AB  - Purpose: Multiple myeloma (MM) remains an incurable disease as tumor cells
      ultimately resist to all available drugs. Homing of tumor cells to the bone
      marrow microenvironment, involving especially the CXCR4/SDF-1 axis, allows them
      to survive, proliferate and resist to therapy. F50067, a humanized anti-CXCR4
      IgG1 antibody, has promising preclinical activity in MM.We present a phase I
      multicenter escalation study in relapsed/refractory MM (RRMM) to determine the
      maximum tolerated dose (MTD) for F50067 alone and in combination with
      lenalidomide and low dose dexamethasone (Len-Dex). Experimental design: 14 end
      stage RRMM patients received F50067 single agent (n = 10) or in combination with
      Len-Dex (n = 4). Results: One dose-limiting toxicity was observed, a grade 4
      neutropenia lasting more than 7 days in combination arm. MTD could not be
      established. Thrombocytopenia was observed in 100% and neutropenia in 92.9% of
      patients with no cases of febrile neutropenia and no severe bleeding or hematoma.
      Non-hematological adverse events were of mild to moderate severity.Nine patients
      (6 in single arm and 3 in combination arm) were evaluable for response, with
      66.7% overall response rate (>=PR) in combination arm, and 33.3% of disease
      control (>=SD) in single agent arm. At the time of study termination, 55.6% had
      progressed. Conclusion: This study suggests that egression of tumor cells to the
      blood stream can represent a novel therapeutic strategy for MM. However, because
      of significant hematological toxicity, this study had to be discontinued. Further
      studies are needed to validate the feasibility of this approach in clinical
      practice.

PMID- 29844861
TI  - Pharmacologic activation of peroxisome proliferator-activating receptor-alpha
      accelerates hepatic fatty acid oxidation in neonatal pigs.
AB  - Up-regulation of peroxisome proliferator-activating receptor-alpha (PPARalpha)
      and increasing fatty acid oxidation are important for reducing pre-weaning
      mortality of pigs. We examined the time-dependent regulatory effects of PPARalpha
      activation via oral postnatal clofibrate administration (75 mg/(kg-BW.d) for up
      to 7 days) on mitochondrial and peroxisomal fatty acid oxidation in pigs, a
      species with limited hepatic fatty acid oxidative capacity due to low
      ketogenesis. Hepatic oxidation was increased by 44-147% (depending on fatty acid
      chain-length) and was attained after only 4 days of clofibrate treatment. Acyl
      CoA oxidase (ACO) and carnitine palmitoyltransferase I (CPTI) activities
      accelerated in parallel. The increase in CPTI activity was accompanied by a rapid
      reduction in the sensitivity of CPTI to malonyl-CoA inhibition. The mRNA
      abundance of CPTI and ACO, as well as peroxisomal keto-acyl-CoA thiolase
      (KetoACoA) and mitochondrial malonyl-CoA decarboxylase (MCD), also were augmented
      greatly. However, the increase in ACO activity and MCD expression were different
      from CPTI, and significant interactions were observed between postnatal age and
      clofibrate administration. Furthermore, the expression of acetyl-CoA carboxylase
      beta (ACCbeta) decreased with postnatal age and clofibrate had no effect on its
      expression. Collectively these results demonstrate that the expression of
      PPARalpha target genes and the increase in fatty acid oxidation induced by
      clofibrate are time- and age-dependent in the liver of neonatal pigs. Although
      the induction patterns of CPTI, MCD, ACO, KetoACoA, and ACCbeta are different
      during the early postnatal period, 4 days of exposure to clofibrate were
      sufficient to robustly accelerate fatty acid oxidation.

PMID- 29844862
TI  - Genetic variants in lncRNA H19 are associated with the risk of oral squamous cell
      carcinoma in a Chinese population.
AB  - To evaluate whether the genetic variants in H19 influence the risk of oral
      squamous cell carcinoma (OSCC) in a Chinese population, a case-control study was
      conducted to analyze four functional single nucleotide polymorphisms (SNPs) in
      H19. The cohort comprised of 444 OSCC cases and 984 healthy controls, and the
      study further evaluated the biological effect by bioinformatics prediction and
      functional experiments. Two SNPs, rs217727 and rs2839701, were found to be
      associated with the risk of OSCC [rs217727: odds ratio (OR) = 1.32, 95%
      confidence interval (CI) = 1.11-1.58, P = 0.002; rs2839701: OR = 1.23, 95% CI =
      1.04-1.46, P = 0.019].Bioinformatics predicted that rs2839701 C>G might alter the
      secondary structure of H19. In addition, rs2839701 C>G inhibited the
      transcription activity and was correlated with the decreased expression of
      downstream gene MRPL23-AS1 that was downregulated in OSCC. The current results
      suggested that the SNPs in H19 may play a major role in genetic susceptibility to
      OSCC.

PMID- 29844863
TI  - PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates
      DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy
      in intracranial glioblastoma.
AB  - Via extensive analyses of genetic databases, we have characterized the DNA-repair
      capacity of glioblastoma with respect to patient survival. In addition to
      elevation of O6-methylguanine DNA methyltransferase (MGMT), down-regulation of
      three DNA repair pathways; canonical mismatch repair (MMR), Non-Homologous End
      Joining (NHEJ), and Homologous Recombination (HR) are correlated with poor
      patient outcome. We have designed and tested both in vitro and in vivo, a
      monoamine oxidase B (MAOB) specific prodrug, PAM-OBG, that is converted by glioma
      MAOB into the MGMT inhibitor O6-benzylguanine (O6BG) and the DNA crosslinking
      agent acrolein. In cultured glioma cells, we show that PAM-OBG is converted to
      O6BG, inhibiting MGMT and sensitizing cells to DNA alkylating agents such as
      BCNU, CCNU, and Temozolomide (TMZ). In addition, we demonstrate that the acrolein
      generated is highly toxic in glioma treated with an inhibitor of Nucleotide
      Excision Repair (NER). In mouse intracranial models of primary human glioma, we
      show that PAM-OBG increases survival of mice treated with either BCNU or CCNU by
      a factor of six and that in a chemoradiation model utilizing six rounds of
      TMZ/2Gy radiation, pre-treatment with PAM-OBG more than doubled survival time.

PMID- 29844864
TI  - MicroRNA-146a suppresses rheumatoid arthritis fibroblast-like synoviocytes
      proliferation and inflammatory responses by inhibiting the TLR4/NF-kB signaling.
AB  - This study investigated whether microRNA-146a (miR-146a) mediating TLR4/NF-kappaB
      pathway affected proliferation and inflammatory responses of rheumatoid arthritis
      fibroblast-like synoviocytes from 12 RA patients (RA-FLSs). FLSs in the
      logarithmic growth phase were assigned into the control, miR-146a mimic miR-146a
      inhibitor, Tak-242 (treated with TLR4/NF-kappaB pathway inhibitor) and mimic +
      lipopolysaccharide (LPS) groups. Cell proliferation and apoptosis were detected
      using CCK-8 assay and flow cytometry. The expression of miR-146a, TLR4/NF-kappaB
      pathway-related proteins and cytokines were determined by RT-qPCR, western
      blotting and ELISA, and the release of NO by Greiss reaction. RA rat models were
      constructed and the primary cells were classified into the control, negative
      control (NC), miR-146a mimic, miR-146a inhibitor, Tak-242, mimic + LPS, and TLR4
      groups. Immunohistochemistry was used to detect the expression of proliferating
      cell nuclear antigen (PCNA) and intercellular adhesion molecular-1 (ICAM-1). The
      results showed that miR-146a levels were lower in RA-FLSs than control
      fibroblasts. miR-146a mimic and Tak-242 decreased RA-FLS proliferation and
      increased RA-FLS apoptosis, while miR-146a inhibitor had an opposite trend. miR
      146a mimic and Tak-242 also decreased expression of TLR4, NF-kappaB, IL-1beta, IL
      6, IL-8, IL-17, COX-2, MMP-3, Seprase, and iNOS, as well as reduced NO level in
      RA-FLSs while miR-146a inhibitor and TLR4 increased them. TLR4 and NF-kappaB
      levels and the positive rates of PCNA and ICAM-1 expressions were lower in RA
      FLSs from RA rats given miR-146a mimic from control or miR-146a inhibitor-treated
      rats. These results suggest that miR-146a inhibits the proliferation and
      inflammatory response of RA-FLSs by down-regulating TLR4/NF-kappaB pathway.

PMID- 29844865
TI  - Identification of different mutational profiles in cancers arising in specific
      colon segments by next generation sequencing.
AB  - The objective of this study was to investigate the mutational profiles of cancers
      arising in different colon segments. To this aim, we have analyzed 37 colon
      cancer samples by use of the Ion AmpliSeqTM Comprehensive Cancer Panel. Overall,
      we have found 307 mutated genes, most of which already implicated in the
      development of colon cancer. Among these, 15 genes were mutated in tumors
      originating in all six colon segments and were defined "common genes" (i.e. APC,
      PIK3CA, TP53) whereas 13 genes were preferentially mutated in tumors originating
      only in specific colon segments and were defined "site-associated genes" (i.e.
      BLNK, PTPRD). In addition, the presence of mutations in 10 of the 307 identified
      mutated genes (NBN, SMUG1, ERBB2, PTPRT, EPHB1, ALK, PTPRD, AURKB, KDR and
      GPR124) were found to be of clinical relevance. Among clinically relevant genes,
      NBN and SMUG1 were identified as independent prognostic factors that predicted
      poor survival in colon cancer patients. In conclusion, the findings reported here
      indicate that tumors arising in different colon segments present differences in
      the type and/or frequency of genetic variants, with two of them being independent
      prognostic factors that predict poor survival in colon cancer patients.

PMID- 29844866
TI  - Expression of the onconeural protein CDR1 in cerebellum and ovarian cancer.
AB  - Cerebellar degeneration related protein 1 (CDR1) is expressed in the cerebellum,
      and CDR1 antibodies have been associated with paraneoplastic cerebellar
      degeneration (PCD). In this study, we examined CDR1 expression in cerebellum and
      in ovarian and breast tumors, as well as the intracellular localization of CDR1
      in cancer cells in culture. CDR1 was strongly expressed in the cytosol and
      dendrites of Purkinje cells and in interneurons of the molecular layer in
      cerebellum. CDR1 was also present in ovarian and breast tumors, as well as in
      ovarian and breast cancer cell lines, but was not present in normal breast or
      ovarian tissue. In cells overexpressing CDR1, CDR1 localized close to the plasma
      membrane in a polarized pattern at one edge. CDR1 was strongly expressed on the
      outer surface, apparently in filopodias or lamellipodias, in cells endogenously
      expressing CDR1. Overexpression of CDR1 showed a 37 and a 45 kDa band in western
      blot. The 37-kDa isoform was present in 16 ovarian cancer lysates, while the 45
      kDa isoform was only found in three ovarian cancer patients. The presence of CDR1
      in ovarian cancer was not associated with PCD. CDR1 antibodies were only found in
      serum from one patient with PCD and ovarian tumor with metastases. Therefore,
      CDR1 is probably not a marker for PCD. However, CDR1 may be associated with cell
      migration and differentiation.

PMID- 29844867
TI  - The effect of the type of dietary protein on the development of ovarian cancer.
AB  - We evaluated whether different dietary protein qualities (isocaloric diets
      involving animal (casein) or plant protein (soy protein) could inhibit the
      ovarian cancer growth in mice and improve their prognosis and whether
      chemotherapy had different tumor reducing effects on these mice. In the mice of
      the 20% plant protein group, the ovarian cancer growth at 5 weeks after tumor
      implantation was clearly reduced in comparison to the mice in the 20% animal
      protein group (p< 0.001). The serum levels of insulin and IGF-1 levels were both
      lower in the mice of the 20% plant protein group than in the mice of the 20%
      animal protein group (p<0.001 and p<0.01, respectively). Immunohistochemistry
      revealed that the level of eukaryotic initiation factor 4E-binding protein 1 (p
      4EBP1) activity-one of the major downstream effectors of the mTOR pathway -of the
      plant protein group was significantly weaker than that of the animal protein
      group (p<0.001). The prognosis of the 20% plant protein group was better than
      that of the 20% animal protein group (log-rank test, p=0.0062). The ovarian
      cancer growth in the 20% plant protein plus cisplatin treatment group was not
      significantly reduced in comparison to the 20% animal protein plus cisplatin
      treatment group. Our findings suggest that a diet high in plant protein reduces
      the growth of human ovarian cancer cells in mice compared to a diet high in
      animal protein, -possibly through the lack of activation of the IGF/Akt/mTOR
      pathway, and leads to a better prognosis with or without cisplatin treatment.

PMID- 29844868
TI  - Clinical features of squamous cell lung cancer with anaplastic lymphoma kinase
      (ALK)-rearrangement: a retrospective analysis and review.
AB  - Anti-anaplastic lymphoma kinase (ALK)-targeted therapy dramatically improves
      therapeutic responses in patients with ALK-rearranged lung adenocarcinoma (Ad
      LC). A few cases of squamous cell lung carcinoma (Sq-LC) with ALK rearrangement
      have been reported; however, the clinicopathological features and clinical
      outcomes following treatment with ALK inhibitors are unknown. We addressed this
      in the present study by retrospectively comparing the clinical characteristics of
      five patients with ALK-rearranged Sq-LC with those of patients with ALK
      rearranged Ad-LC and by evaluating representative cases of ALK inhibitor
      responders and non-responders. The prevalence of ALK rearrangement in Sq-LCs was
      1.36%. Progression-free survival (PFS) after initial treatment with crizotinib
      was significantly shorter in Sq-LC than in Ad-LC with ALK rearrangement (p =
      0.033). Two ALK rearrangements assayed by fluorescence in situ hybridization
      (FISH)-positive/immunohistochemistry-negative cases did not respond to crizotinb,
      and PFS decreased following alectinib treatment of ALK-rearranged Sq-LC (p =
      0.045). A rebiopsy revealed that responders to ceritinib harbored the L1196M
      mutation, which causes resistance to other ALK inhibitors. However, non
      responders were resistant to all ALK inhibitors, despite the presence of ALK
      rearrangement in FISH-positive circulating tumor cells and circulating free DNA
      and absence of the ALK inhibitor resistance mutation. These results indicate that
      ALK inhibitors remain a reasonable therapeutic option for ALK-rearranged Sq-LC
      patients who have worse outcomes than ALK-rearranged Ad-LC patients and that
      resistance mechanisms are heterogeneous. Additionally, oncologists should be
      aware of the possibility of ALK-rearranged Sq-LC based on clinicopathological
      features, and plan second-line therapeutic strategies based on rebiopsy results
      in order to improve patient outcome.

PMID- 29844869
TI  - Cancer astrocytes have a more conserved molecular status in long recurrence free
      survival (RFS) IDH1 wild-type glioblastoma patients: new emerging cancer players.
AB  - Glioblastoma is a devastating disease that despite all the information gathered
      so far, its optimal management remains elusive due to the absence of validated
      targets from clinical studies. A better clarification of the molecular mechanisms
      is needed. In this study, having access to IDH1 wild-type glioblastoma of
      patients with exceptionally long recurrence free survival (RFS), we decided to
      compare their mutational and gene expression profile to groups of IDH1 wild-type
      glioblastoma of patients with shorter RFS, by using NGS technology. The exome
      analysis revealed that Long-RFS tumors have a lower mutational rate compared to
      the other groups. A total of 158 genes were found differentially expressed among
      the groups, 112 of which distinguished the two RFS extreme groups. Overall, the
      exome data suggests that shorter RFS tumors could be, chronologically, in a more
      advanced state in the muli-step tumor process of sequential accumulation of
      mutations. New players in this kind of cancer emerge from the analysis, confirmed
      at the RNA/DNA level, identifying, therefore, possible oncodrivers or tumor
      suppressor genes.

PMID- 29844871
TI  - Pericytes/vessel-associated mural cells (VAMCs) are the major source of key
      epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma.
AB  - Epithelial-to-mesenchymal transition (EMT) is supposed to be responsible for
      increased invasion and metastases in epithelial cancer cells. The activation of
      EMT genes has further been proposed to be important in the process of malignant
      transformation of primary CNS tumors. Since the cellular source and clinical
      impact of EMT factors in primary CNS tumors still remain unclear, we aimed at
      deciphering their distribution in vivo and clinico-pathological relevance in
      human gliomas. We investigated 350 glioma patients for the expression of the key
      EMT factors SLUG and TWIST by immunohistochemistry and immunofluorescence related
      to morpho-genetic alterations such as EGFR-amplification, IDH-1 (R132H) mutation
      and 1p/19q LOH. Furthermore, transcriptional cluster and survival analyses were
      performed. Our data illustrate that SLUG and TWIST are overexpressed in gliomas
      showing vascular proliferation such as pilocytic astrocytomas and glioblastomas.
      EMT factors are exclusively expressed by non-neoplastic pericytes/vessel
      associated mural cells (VAMCs). They are not associated with patient survival but
      correlate with pericytic/VAMC genes in glioblastoma cluster analysis. In summary,
      the upregulation of EMT genes in pilocytic astrocytomas and glioblastomas
      reflects the level of activation of pericytes/VAMCs in newly formed blood
      vessels. Our results underscore that the negative prognostic potential of the EMT
      signature in the group of diffuse gliomas of WHO grade II-IV does most likely not
      derive from glioma cells but rather reflects the degree of proliferating mural
      cells thereby constituting a potential target for future alternative treatment
      approaches.

PMID- 29844872
TI  - Polymorphisms in the promoter region of the CRBN gene as a predictive factor for
      the first-line CTD therapy in multiple myeloma patients.
AB  - Cereblon is a primary molecular target for immunomodulatory drugs. The aim of
      this study was to evaluate the influence of selected clinical and molecular
      factors including single nucleotide polymorphisms (SNPs) in CRBN gene on the
      efficacy of first line CTD (cyclophosphamide, thalidomide, dexamethasone)
      chemotherapy in patients with multiple myeloma. Study group consisted of 68
      patients. Analysis of CRBN gene SNPs (rs6768972, rs1672753) was performed using
      Real-Time PCR genotyping technique. Median progression free survival (PFS) was 15
      months and overall survival (OS) 79 months. Factors associated with significantly
      shorter OS included ISS 3, kidney disease, weight loss, anemia, thrombocytopenia,
      hypoalbuminemia, elevated beta2-microglobuline and CRP. The presence of t(4;14)
      was associated with significantly shorter PFS and OS. Both examined SNPs proved
      to be statistically significant, independent predictive factors of efficacy of
      the CTD chemotherapy. The presence of AA genotype (rs6768972) correlated with
      longer median PFS (18 vs 9 months; HR=0.49,95% CI: 0.26-0.91, p=0.0062).
      Conversely, in the carriers of CC genotype (rs1672753) significantly shorter
      median PFS was observed (4 vs 16 months; HR=3.93, 95% CI: 0.26-59.64, p=0.0321).
      In conclusion, SNPs of the CRBN gene may be useful in qualifying patients for
      treatment with regimens containing thalidomide.

PMID- 29844870
TI  - Dietary inflammatory index and risk of upper aerodigestive tract cancer in
      Japanese adults.
AB  - Background: The inflammatory potential of diet that has been shown to be
      associated with cancer risk. We examined the association between dietary
      inflammatory potential as measured by the dietary inflammatory index (DII(r)) and
      risk of upper aerodigestive tract cancers in a Japanese case-control study.
      Results: A positive association was observed between increasing DII scores and
      overall upper aerodigestive tract cancers, and across anatomic subsites. For
      upper aerodigestive tract cancers, the ORQ4vsQ1 = 1.73 (95% CI: 1.37-2.20); head
      and neck cancer, the ORQ4vsQ1 was 1.92 (95% CI: 1.42-2.59); and for esophageal
      cancer, the ORQ4vsQ1 was1.71 (95% CI: 1.54-1.90). Risks for hypopharyngeal and
      nasopharyngeal cancers were greatly elevated: (ORQ4vsQ1 = 4.05 (95% CI: 1.24
      13.25) for hypopharyngeal cancer and ORQ4vsQ1 = 4.99 (95% CI: 1.14-21.79) for
      nasopharyngeal cancer. Conclusion: A more pro-inflammatory diet was associated
      with an elevated risk of upper aerodigestive tract cancers after accounting for
      important confounders. All anatomic subsites, except larynx, showed the
      consistently elevated risk with increasing DII score. Those subsites with known
      etiological associations with persistent infection showed the largest elevation
      in risk. These results warrant further evaluation in future studies. Materials
      and Methods: This is a case-control study of 1,028 cases and 3,081 age- and sex
      matched non-cancer controls recruited at Aichi Cancer Center. DII scores were
      computed based on estimates of macro- and micro-nutrients from a self
      administered food frequency questionnaire. Scores were further categorized into
      quartiles (based on the distribution in controls). Conditional logistic
      regression models were fit to estimate odds ratio (OR) and 95% confidence
      intervals (CIs) adjusted for smoking, ethanol consumption, alcohol flushing,
      number of teeth, and occupation group.

PMID- 29844873
TI  - Synergistic potentiation of the anti-metastatic effect of anti EGFR mAb by its
      combination with immunotherapies targeting the ganglioside NGcGM3.
AB  - Several Anti-EGFR mAbs are register for the treatment of human cancer. However,
      their impact on patients overall survival has been limited by tumor resistance. N
      Glycolyl variant of GM3 ganglioside (NGcGM3) is specifically expressed in some
      human tumors, and it has been associated with a poor prognosis. Several reports
      have documented that GM3 physically associates to EGFR inhibiting its ligand
      depend phosphorylation, but it also facilitates an alternative/compensatory
      signaling cascade mediated by Uroquinase Plasminogen Activator Receptor (uPAR)
      and integrin alpha5beta1 interaction. However, the difference between NGc and N
      Acetylated (NAc) variants of GM3 regarding such interactions is unknown. We
      hypothesized that enrichment of NGcGM3 expression in tumors relates to advantages
      of this ganglioside, on ensuring both EGFR and uPAR pathways optimal function. We
      explored the impact of combining an anti-EGFR (7A7 mAb) with anti-NGcGM3
      therapies: NGcGM3/VSSP vaccine or 14F7 mAb. Both combinations synergistically
      increase overall survival in two models of lung metastasis: 3LL-D122 and 4T1; but
      combination with NGcGM3/VSSP vaccine is significantly more effective. In 3LL-D122
      metastasis, of mice treated with the best combination, both EGFR and
      uPAR/alpha5beta1 integrin pathways are turn off (I.e expression of
      uPAR/alpha5beta1; and phosphorylation of EGFR, Stat3, Src and FAK are reduced);
      and tumor angiogenesis is decreased. Interestingly, combination treatment
      increases tumor infiltrating CD4+T, CD8+T and NK+-cells. Furthermore, a positive
      clinical outcome is reported for a cancer patient treated with an anti-EGFR mAb
      and anti-NGcGM3 therapy. Overall, our results support the combination of anti
      EGFR antibodies with therapies targeting NGcGM3 to increase their efficacy in
      future clinical trials.

PMID- 29844874
TI  - Combined assessment of the TNM stage and BRAF mutational status at diagnosis in
      sporadic colorectal cancer patients.
AB  - The prognostic impact of KRAS mutations and other KRAS-related and non-related
      genes such as BRAF, NRAS and TP53, on sporadic colorectal cancer (sCRC) remain
      controversial and/or have not been fully established. Here we investigated the
      frequency of such mutations in primary sCRC tumors and their impact on patient
      progression-free survival (PFS) and overall survival (OS). Primary tumor tissues
      from 87 sCRC patients were analysed using a custom-built next generation
      sequencing (NGS) panel to assess the hotspot mutated regions of KRAS/NRAS (exons
      2, 3 and 4), BRAF (exon 15) and TP53 (all exons). Overall, mutations in these
      genes were detected in 46/87 sCRC tumors analyzed (53%) with the following
      frequencies per gene: TP53, 33%; KRAS, 28%; BRAF, 7%; and NRAS, 1%. A significant
      association was found between KRAS mutations and right side colon tumor location
      (p=0.05), well-differentiated tumors (p=0.04) and absence of lymphovascular
      invasion (p=0.05). In turn, BRAF-mutated tumors frequently corresponded to poorly
      or moderately-differentiated sCRC (p=0.02) and showed a higher frequency of
      peritoneal carcinomatosis (p=0.006) and microsatellite instability (p=0.007).
      From the prognostic point of view, the BRAF mutational status together with the
      TNM stage were the only variables that showed an independent adverse impact on
      patient outcome in the multivariate analyses for both PFS and OS. Based on these
      results a scoring system was built and patients were classified into three
      prognostic subgroups with different PFS rates at 2 years: 91% vs. 77% vs. 0%,
      respectively (p<0.0001). Additional prospective studies in larger series of sCRC
      patients where mutations in genes other than those investigated here are required
      to validate the utility of the proposed predictive model.

PMID- 29844875
TI  - Cofilin-1 levels and intracellular localization are associated with melanoma
      prognosis in a cohort of patients.
AB  - Melanoma is an aggressive cancer with highly metastatic ability. We propose
      cofilin-1, a key protein in the regulation of actin dynamics and migration, as a
      prognostic marker. We determined cofilin-1 levels in a retrospective cohort of
      patients with melanomas and benign lesions of melanocytes (nevi) by
      immunohistochemistry. Higher cofilin-1 levels were found in malignant melanoma
      (MM) with Breslow Index (BI)>2 vs MM with BI<2, melanoma in situ (MIS) and nevi
      and also in MM with metastasis vs MM without detected metastasis. Kaplan-Meier
      survival curves were performed, clustering patients according to either the type
      of melanocytic lesions or cofilin-1 level. Survival curves demonstrated worse
      prognosis of patients with high vs low cofilin-1 levels. TCGA database analysis
      of melanoma also showed low survival in patients with upregulated cofilin-1 mRNA
      vs patients without alteration in CFL1 mRNA expression. As cofilin-1 has a dual
      function depending on its intracellular localization, we evaluated nuclear and
      cytoplasmic levels of cofilin-1 in melanoma and nevi samples by
      immunofluorescence. MM with high Breslow index and metastatic cells not only
      presented cytoplasmic cofilin-1, but also showed this protein at the nucleus. An
      increase in nuclear/cytoplasmic cofilin-1 mean fluorescence ratio was observed in
      MM with BI>2 vs MM with BI<2, MIS and nevi. In conclusion, an association of
      cofilin-1 levels with malignant features and an inverse correlation with survival
      were demonstrated. Moreover, this study suggests that not only the higher levels
      of cofilin-1, but also its nuclear localization can be proposed as marker of
      worse outcome of patients with melanoma.

PMID- 29844876
TI  - Nickel chloride administration prevents the growth of oral squamous cell
      carcinoma.
AB  - The effect of NiCl2 on oral squamous cell carcinoma-derived cell line HSC3 was
      examined. Incubation with 1 mM NiCl2 significantly reduced the expression of MMPs
      at mRNA and protein levels. The in vivo orthotopic implantation model was
      established by injecting highly metastatic subcell line HSC3-M3 to nude mouse
      tongue. After 1 week of injection, mice were fed with or without 1 mM NiCl2
      containing water for two to three weeks. Immunohistochamical examination revealed
      that MMP9 expression was drastically reduced in NiCl2-fed mice. By CT images,
      cancer mass was observed as a translucent area in control mice. In NiCl2-fed
      mice, much highly translucent area was observed within the translucent area.
      Histologically, this area corresponded to the necrotic area in the tumor mass.
      Real-time PCR analysis revealed the reduced expression of angiogenic factors such
      as IL-8 and VEGF mRNA in NiCl2-fed mice. To further examine the effect of NiCl2
      on metastasis, human beta-globin gene expression in regional lymphnodes was
      compared. The beta-globin gene was totaly absent in NiCl2-fed mice. Moreover,
      various cancer metastasis-related genes were inhibited in NiCl2-fed mice by PCR
      array analysis. The results indicated that NiCl2 might be a promising new anti
      cancer therapeutics for the oral cancer treatment.

PMID- 29844877
TI  - Etoposide-induced DNA damage affects multiple cellular pathways in addition to
      DNA damage response.
AB  - DNA damage response (DDR) coordinates lesion repair and checkpoint activation.
      DDR is intimately connected with transcription. However, the relationship between
      DDR and transcription has not been clearly established. We report here RNA
      sequencing analyses of MCF7 cells containing double-strand breaks induced by
      etoposide. While etoposide does not apparently cause global changes in mRNA
      abundance, it altered some gene expression. At the setting of fold alteration >=
      2 and false discovery rate (FDR) <= 0.001, FDR < 0.05, or p < 0.05, etoposide
      upregulated 96, 268, or 860 genes and downregulated 41, 133, or 503 genes in MCF7
      cells. Among these differentially expressed genes (DEGs), the processes of
      biogenesis, metabolism, cell motility, signal transduction, and others were
      affected; the pathways of Ras GTPase activity, RNA binding, cytokine-mediated
      signaling, kinase regulatory activity, protein binding, and translation were
      upregulated, and those pathways related to coated vesicle, calmodulin binding,
      and microtubule-based movement were downregulated. We further identified RABL6,
      RFTN2, FAS-AS1, and TCEB3CL as new DDR-affected genes in MCF7 and T47D cells. By
      metabolic labelling using 4-thiouridine, we observed dynamic alterations in the
      transcription of these genes in etoposide-treated MCF7 and T47D cells. During 0-2
      hour etoposide treatment, RABL6 transcription was robustly increased at 0.5 and 1
      hour in MCF7 cells and at 2 hours in T47D cells, while FAS-AS1 transcription was
      dramatically and steadily elevated in both cell lines. Taken together, we
      demonstrate dynamic alterations in transcription and that these changes affect
      multiple cellular processes in etoposide-induced DDR.

PMID- 29844878
TI  - Genome-wide multi-omics profiling of the 8p11-p12 amplicon in breast carcinoma.
AB  - Genomic instability contributes to the neoplastic phenotype by deregulating key
      cancer-related genes, which in turn can have a detrimental effect on patient
      outcome. DNA amplification of the 8p11-p12 genomic region has clinical and
      biological implications in multiple malignancies, including breast carcinoma
      where the amplicon has been associated with tumor progression and poor prognosis.
      However, oncogenes driving increased cancer-related death and recurrent genetic
      features associated with the 8p11-p12 amplicon remain to be identified. In this
      study, DNA copy number and transcriptome profiling data for 229 primary invasive
      breast carcinomas (corresponding to 185 patients) were evaluated in conjunction
      with clinicopathological features to identify putative oncogenes in 8p11-p12
      amplified samples. Illumina paired-end whole transcriptome sequencing and whole
      genome SNP genotyping were subsequently performed on 23 samples showing high
      level regional 8p11-p12 amplification to characterize recurrent genetic variants
      (SNPs and indels), expressed gene fusions, gene expression profiles and allelic
      imbalances. We now show previously undescribed chromothripsis-like patterns
      spanning the 8p11-p12 genomic region and allele-specific DNA amplification
      events. In addition, recurrent amplification-specific genetic features were
      identified, including genetic variants in the HIST1H1E and UQCRHL genes and
      fusion transcripts containing MALAT1 non-coding RNA, which is known to be a
      prognostic indicator for breast cancer and stimulated by estrogen. In summary,
      these findings highlight novel candidate targets for improved treatment of 8p11
      p12 amplified breast carcinomas.

PMID- 29844879
TI  - Clinical application of angiotensin receptor blockers in patients with non
      alcoholic fatty liver disease: a systematic review and meta-analysis.
AB  - Objective: Non-alcoholic fatty liver disease (NAFLD) is one of the most common
      chronic liver diseases, ranging from simple steatosis to progressive
      steatohepatitis and cirrhosis. Because of their anti-inflammatory and anti
      fibrotic effects, angiotensin receptor blockers (ARBs) are potential therapeutic
      agents for NAFLD. The present systematic review assessed the effectiveness of
      ARBs in NAFLD management. Results: Accounting for data overlap and exclusion
      criteria, randomized controlled trial -based and single-arm meta-analyses were
      conducted for four studies with 362 patients and eight studies with 525 patients,
      respectively. Although alanine aminotransferase levels were not significantly
      affected by ARB treatment (standardized mean difference 0.20; 95% confidence
      interval (CI) [-0.04, 0.44]; P = 0.10), a fixed-effect model revealed a
      decreasing trend in alanine transaminase levels. Low-density lipoprotein levels
      were reduced by ARB treatment (MD 5.21; 95% CI [3.01, 7.40]; P < 0.00001), and
      total cholesterol also decreased in response to ARBs (MD 2.10; 95% CI [-0.37,
      4.57]; P = 0.10). However, the fibrosis score and NAFLD activity score were not
      significantly improved by ARB treatment (MD 0.10; 95% CI [-0.58, 0.78]; P = 0.77)
      (MD -0.25; 95% CI [-1.05, 0.55]; P = 0.53). Materials and Methods: Keywords were
      used to identify studies in PubMed, EMBASE, CENTRAL, Web of Science and CNKI
      published up to July 31, 2017. Single-arm and RCT-based meta-analyses of the
      available data were performed using RevMan (version 5.3). Conclusions: Although
      ARBs significantly decreased plasma low-density lipoprotein and total cholesterol
      levels, the current evidence is insufficient to support the efficacy of ARBs in
      managing fibrosis in NAFLD patients.

PMID- 29844880
TI  - Network meta-analysis of surgical treatment for unstable femoral
      intertrochanteric fractures.
AB  - In this network meta-analysis, we determined the optimal surgical method for
      treating unstable femoral intertrochanteric fractures. We searched the EMBASE,
      Cochrane Library and Medline databases for studies evaluating sliding hip screws
      (SHS), gamma nail (GN) or proximal femoral nail antirotation (PFNA) methods, and
      included nine randomized controlled trials that met the inclusion criteria. Our
      analysis showed no differences in the rates of complications between SHS and PFNA
      relative to GN (p > 0.05). However, the surface under the cumulative ranking
      curve (SUCRA) score for PFNA (77.6%) was higher than the SUCRA scores for GN
      (65%) and SHS (7.5%). This suggests PFNA is the better surgical method than GN or
      SHS for unstable femoral intertrochanteric fractures.

PMID- 29844881
TI  - Prognostic utility of global longitudinal strain in myocardial infarction.
AB  - Cardiovascular magnetic resonance (CMR) represents the reference standard for
      cardiac morphology and function assessment. Since introduction in 2009, CMR
      feature tracking (CMR-FT) has become a frequently used tool in the assessment of
      myocardial deformation and wall motion on the basis of routinely acquired b-SSFP
      cine images. Extensive validation has led to excellent intra- and inter-observer
      as well as inter-study reproducibility. CMR-FT derived myocardial deformation
      indices such as left ventricular (LV) strain have been shown to be impaired in
      cardiac diseases such as cardiomyopathies as well as myocardial infarction.
      Although LV ejection fraction (LVEF) is the routinely and frequently utilized
      parameter for systolic myocardial function assessment and major adverse clinical
      event (MACE) prediction, it fails to assess regional differences. Recently, LV
      strain has emerged as a superior measure for risk assessment and MACE prediction
      as compared to the established markers e.g., LVEF. This editorial aims to
      elucidate current discussions in the field of strain assessment in myocardial
      infarction in the light of recent data from a large prospective multicentre CMR
      study.

PMID- 29844882
TI  - Children's perspectives on life and well-being after parental intimate partner
      homicide.
AB  - Background: While there is no doubt that parental intimate partner homicide is
      associated with strong grief and post-traumatic stress reactions among the
      children who have been bereaved, there is little in-depth insight into how
      children and young people see and describe their circumstances and needs.
      Objective: Our aim was to shed light on children's and young people's
      perspectives on their life after parental intimate partner homicide. In
      particular, we were interested in how they experienced their living arrangements,
      social environment, and general well-being. Method: We conducted semi-structured
      interviews with 23 children and young people (8-24 years old; 15 females and
      eight males) who had been younger than 18 years when one of their parents killed
      the other (21 children lost their mother, two children lost their father). We
      used thematic analysis to synthesize the findings. Results: While most
      participants were fairly content with themselves and their living arrangements,
      they also expressed substantial and persistent difficulties, including distress,
      conflicts between family members, and feelings of unsafety. Most importantly,
      children's self-image, their perspectives on their biological parents, and their
      views on their broader (family) environment varied considerably from participant
      to participant, and also between siblings. Conclusions: It is unlikely that
      straightforward guidelines can be given with regard to where the children should
      live after parental homicide, or whether they should be in contact with the
      perpetrating parent. Rather, this study's findings underline the need to explore
      children's individual viewpoints carefully during decision-making processes.

PMID- 29844883
TI  - Trauma-focused cognitive behavioural therapy for young children: clinical
      considerations.
AB  - Trauma-focused Cognitive Behavioural Therapy (TF-CBT) has been utilized with
      children of a wide age range and with diverse trauma experiences. This article
      will focus on the application of TF-CBT to young children. After presenting an
      overview of the model, challenges and developmentally-sensitive and creative
      strategies for engaging young children and their caregivers in TF-CBT PRACTICE
      components will be highlighted. A brief review of the strong empirical support
      for TF-CBT will then be provided.

PMID- 29844884
TI  - Family systems approach to attachment relations, war trauma, and mental health
      among Palestinian children and parents.
AB  - Background: Trauma affects the family unit as a whole; however, most existing
      research uses individual or, at most, dyadic approaches to analyse families with
      histories of trauma. Objective: This study aims to identify potentially distinct
      family types according to attachment, parenting, and sibling relations, to
      analyse how these family types differ with respect to war trauma, and to explore
      how children's mental health and cognitive processing differ across these family
      types. Method: Participants included Palestinian mothers and fathers (N = 325)
      and their children (one per family; 49.4% girls; 10-13 years old; mean +/- SD age
      = 11.35 +/- 0.57 years) after the Gaza War of 2008-2009. Both parents reported
      their exposure to war trauma, secure attachment availability, and parenting
      practices, as well as the target child's internalizing and externalizing symptoms
      [Strengths and Difficulties Questionnaire (SDQ)]. Children reported their
      symptoms of post-traumatic stress disorder (on the Children's Revised Impact
      Event Scale), depression (Birleson), and SDQ, as well as their post-traumatic
      cognitions (Children's Post Traumatic Cognitions Inventory). Results: A cluster
      analysis identified four family types. The largest type reflected secure
      attachment and optimal relationships (security and positive family relationships,
      36.2%, n = 102), and the smallest exhibited insecurity and problematic
      relationships (insecurity and negative family relationships, 15.6%; n = 44).
      Further, families with discrepant experiences (23.0%; n = 65) and moderate
      security and neutral relationships (25.2%; n = 71) emerged. The insecurity and
      negative relationships family type showed higher levels of war trauma;
      internalizing, externalizing, and depressive symptoms among children; and
      dysfunctional post-traumatic cognitions than other family types. Conclusion: The
      family systems approach to mental health is warranted in war conditions, and
      therapeutic interventions for children should, thus, also involve parents and
      siblings. Knowledge of unique family attachment patterns is fruitful for
      tailoring therapeutic treatments and preventive interventions for war-affected
      children and families.

PMID- 29844886
TI  - Measuring stroke patients' exercise preferences using a discrete choice
      experiment.
AB  - Physical activity post stroke improves health, yet physical inactivity is highly
      prevalent. Tailored exercise programs considering physical activity preferences
      are a promising approach to promote physical activity. Therefore, this study
      seeks to measure exercise preferences of stroke survivors. Stroke survivors
      conducted a discrete choice experiment (DCE). DCE was presented in a face-to-face
      interview where patients had to choose eight times between two different exercise
      programs. Exercise programs differed by characteristics, with the six attributes
      under consideration being social situation, location, type of exercise,
      intensity, frequency, and duration. Utilities of the exercise attributes were
      estimated with a logit choice model. Stroke survivors (n=103, mean age: 67,
      SD=13.0; 60% male) show significant differences in the rated utilities of the
      exercise attributes (P<0.001). Participants had strong preferences for light and
      moderate intense physical activity and favored shorter exercise sessions. Stroke
      survivors have remarkable exercise preferences especially for intensity and
      duration of exercise. Results contribute to the tailoring of physical activity
      programs after stroke thereby facilitating maintenance of physical activity.

PMID- 29844885
TI  - Does sleep disruption mediate the effects of childhood maltreatment on brain
      structure?
AB  - Background: Childhood maltreatment is associated with alterations in morphology
      of stress susceptible brain regions. Maltreatment is also known to markedly
      increase risk for psychopathology and to have an enduring disruptive effect on
      sleep. Objective: To determine whether abnormalities in sleep continuity have
      effects on brain morphometry and to evaluate the extent to which sleep
      impairments mediate the effects of maltreatment on brain structure. Method:
      Maltreatment and Abuse Chronology of Exposure (MACE) scale ratings, actigraph
      assessed sleep and 3T MRI were obtained on N = 37 18-19-year-old participants
      recruited from the community (N = 34 with neuroimaging). Results: Fourteen
      participants had no history of maltreatment while N = 23 were exposed, on
      average, to 4.7 types of maltreatment. Multiplicity of maltreatment was strongly
      associated with reduced sleep efficiency, increased wake after sleep onset time
      and number/duration of awakenings, which were independent of effects of
      maltreatment on depression and anxiety. The most important predictors of impaired
      sleep were exposure to parental non-verbal emotional abuse at 9-10 years of age.
      Reduced sleep efficiency correlated with reduced grey matter volume in
      hippocampus including CA1 subfield, molecular layer and dentate gyrus as well as
      inferior frontal gyrus and insula. Sleep mediated 39-46% of the effects of
      maltreatment on volume of hippocampal structures and inferior frontal gyrus.
      Conclusions: Actigraph-assessed sleep is disrupted in maltreated late teens and
      mediates a significant portion of the effects of maltreatment on hippocampal
      volume. Studies are needed to assess whether efforts to enhance sleep in
      maltreated children can pre-empt or ameliorate neurobiological consequences of
      maltreatment.

PMID- 29844887
TI  - Risk stratification in laminopathies and Emery Dreifuss muscular dystrophy.
AB  - Laminopathies are genetic disorders due to gene mutation encoding for proteins of
      the nuclear envelope. Patients are at risk of conduction defect, arrhythmia,
      sudden death and heart failure. The authors summarize predictive factors for
      cardiac events reported in the literature in this group of disease.

PMID- 29844888
TI  - Migraine: incorrect self-management for a disabling disease.
AB  - Migraine is an economically and socially relevant pathology but patients'
      consciousness and consequently a proper management is often unsatisfactory. In
      this study, we aimed to evaluate the disease awareness, the general approach and
      the impact on working activity in a population of headache-affected hospital
      workers. During an 18-month period, hospital workers responded to a questionnaire
      investigating headache presence, characteristics and awareness. Specific
      attention was paid to define headache impact on working activities. 1774
      consecutive subjects were enrolled. Headache was documented in 45.7% of the
      sample, migraine in 16.6%. 40.6% of the patients with headache and 50.7% of the
      migraneous subjects had a specialist medical evaluation. Triptans use was
      significantly lower than non-steroidal anti-inflammatory drugs use. 39.5% of
      migraneous complained of attacks during working time, 60.2% acknowledged a
      negative influence on work quality. 25.5% of migraneous patients reported a loss
      of working days attributable to the disease. Migraine is disabling for workers
      with negative consequences on job capacity and quality. Efforts should be made to
      improve disease awareness to stimulate a better diagnostic and therapeutic
      approach.

PMID- 29844889
TI  - Pantothenate kinase-associated neurodegeneration: Clinical aspects, diagnosis and
      treatments.
AB  - Pantothenate Kinase-Associated Neurodegeneration (PKAN) is an autosomal recessive
      disorder characterized by a mutation in the PANK2 gene. The clinical presentation
      may range from only speech disorder to severe generalized dystonia, spasticity,
      Visual loss, dysphagia and dementia. The hallmark of this disease is eyes of the
      tiger sign in the medial aspect of bilateral globus pallidus on T2-weighted MRI
      that is a hyperintense lesion surrounded by hypointensity. Common treatments for
      PKAN disease include anticholinergics, botulinum toxin, Oral and Intrathecal
      baclofen, Iron chelation drugs and surgical procedures such as ablative
      pallidotomy or thalamotomy, Deep brain stimulation. There are many controversies
      about the pathogenesis and treatment of this disease, and in recent years
      interesting studies have been done on PKAN disease and other similar diseases.
      This review summarizes the clinical presentation, etiology, imaging modalities
      and treatment.

PMID- 29844890
TI  - Multilingual website and cyberconsultations for oromandibular dystonia.
AB  - Oromandibular dystonia is a focal dystonia that manifests as involuntary
      masticatory and/or tongue muscle contractions. This movement disorder is
      frequently misdiagnosed as a temporomandibular disorder. Hence, it would be
      useful to establish a method that makes it possible for patients with the
      condition to find appropriate medical institutions by themselves. The author
      produced a website Involuntary movements of the stomatognathic region
      (https://sites. google.com/site/oromandibulardystoniaenglish/) for patients with
      oromandibular dystonia, which is available in twenty languages. It has been
      viewed more than 1,000,000 times by individuals from all over the world. The
      visitors to the site have completed questionnaires and/or sent images or videos
      of their involuntary movements over the internet. Cyberconsultations (remote
      diagnosis) were also performed via SkypeTM. Approximately 1000 patients with
      involuntary stomatognathic movements visited our department. Only 12.5% of the
      patients had previously been diagnosed with or were suspected to have dystonia.
      The findings of this study suggest that the multilingual website has contributed
      to increasing awareness of oromandibular dystonia and that the provision of basic
      telemedicine via the internet can aid the diagnosis and treatment of
      oromandibular dystonia.

PMID- 29844891
TI  - Glioblastoma multiforme subterfuge as acute cerebral hemorrhage: A case report
      and literature review.
AB  - Hemorrhagic related Glioblastoma multiforme (GBM) are rare and characterizes with
      severe clinical scuffle. The etiology of this presentation although not well
      known is believed to be multifactorial. We present a case as well as review on
      the pathogenesis of evolution of the hematoma into ring enhancing features of GBM
      on imaging studies. We present a case of 28 years old man who suddenly went into
      coma for 9 hours preceded with seizures that latest for 10 minutes. He had no
      focal neurological signs. CT-Scans images indicated acute cerebral hemorrhage
      near the frontal horn of the left ventricle with brain edema about the
      hemorrhagic lesion and MRI done a week later revealed a cerebral ring enhancing
      lesion. The lesion was partially resected during surgery and immunohistochemical
      staining confirmed GBM (WHO, grade 4). The diagnosis of intratumoral hemorrhage
      in GBM was very challenging at the initial stages but with time the hematoma
      evolved into ring enhancing images typical of GBM. It's not every intracranial
      hematoma that is of pure vascular origin.

PMID- 29844892
TI  - Glioma research: Early detection of a downward trend in publication productivity?
AB  - Global publication productivity for brain tumors was examined on a annual basis
      and compared to other neurologic disorders including stroke, epilepsy and
      Alzheimer's disease. An early downward trend is suggested for 2016; possible
      links to fluctuations in funding is discussed.

PMID- 29844893
TI  - Stroke networks and telemedicine: An Italian national survey.
AB  - Stroke is the leading cause of disability and death. Nowadays, clinical benefits
      of stroke units and thrombolysis in ischemic stroke are evidence-based. Also the
      benefit of endovascular treatment for acute ischemic stroke has been established.
      Telemedicine has been used to improve access to care by allowing a neurologist at
      a remote location to interact with the patient and their family members. Prior
      studies have shown that the use of telemedicine for acute ischemic stroke is not
      only safe and effective, but it also increases the utilization of tPA, improving
      patient outcomes. This study aimed to investigate the diffusion of telemedicine
      in Italian stroke networks with an online questionnaire to assess: type of stroke
      care setting, Volume of thrombolysis- thrombectomy/year, access to stroke care
      between different hospitals, the presence of imaging sharing protocols within the
      network or patients dispatchment screening; type of network solutions. We have
      interviewed 24 Italian neurologists, working in large urban areas, from north
      southward, including Italian islands. In particular, these neurologists
      represented 14 different regions and 20 countries. A majority of neurologists
      replying to the survey (47.83%) worked in large general hospitals or smaller
      general hospitals (26%) and a smaller number of physicians (17.3%) were committed
      in University Hospital or (8.7%) independent foundation hospitals. The 60.87% of
      stroke networks involved in the survey had a low thrombolysis/year volume while
      the 30.43% had a thrombolysis/year volume above 100. According to the survey a
      local stroke network was established in 87.50% of cases. In the 45.83% of cases,
      the hospitals care is not homogeneous within the network. A network for the
      consultation of neuroimaging between hospitals is available in 33.33% of cases.
      Whitin those describing an active network for Teleconsult the 57.14% used
      personal devices, while only the 25 % use professional teleconference system, and
      in 25% of cases used medical devices. Our findings demonstrated a relevant
      diffusion of Teleconsult in Italian stroke networks. The systems adopted are
      mostly individual solutions not integrated in protocolled pathways. These
      findings may encourage a systematization of Telemedicine medical curricula to
      increase larger access to neurological consults.

PMID- 29844894
TI  - A giant cholesteatoma of the mastoid extending into the foramen magnum: A case
      report and review of literature.
AB  - Cholesteatomas are very rare benign, progressive lesions that have embryologic
      derivation and usually result in progressive exfoliation and confinement of
      squamous epithelium behind an intact or preciously infected tympanic membrane. To
      the best of our understanding no reports demonstrates the extension of
      cholesteatoma from the temporal bone into the foramen magnum. We therefore
      present a case of cholesteatoma extending down into the foramen magnum. We report
      a case of 67- year-old man with a giant cholesteatoma extending into the foramen
      magnum without substantial destruction of the mastoid and petrous temporal bones.
      The patient's major symptoms were recurrent tinnitus in the left ear and
      dizziness with unilateral conductive hearing loss. A working diagnosis of
      cholesteatomas was made combining the symptoms and magnetic resonance imaging
      findings. He was then successfully operated on with very minimal postoperative
      complications. Cholesteatomas originating from the mastoid bone often linger with
      the patients for many years in a subclinical state and progress into a massive
      size before causing symptoms. Patients with unilateral conductive hearing loss
      who are otherwise asymptomatic and have a normal tympanic membrane should be
      suspected with a progressive cholesteatoma. Cholesteatoma should be one of the
      working diagnosis when an elderly patient present with unilateral conductive
      hearing loss that is associated with tinnitus and dizziness.

PMID- 29844895
TI  - An unusual stereoretentive 1,3-quaternary carbon shift resulting in an
      enantioselective RhII-catalyzed formal [4+1]-cycloaddition between diazo
      compounds and vinyl ketenes.
AB  - Enantioselective quaternary carbon construction in the assembly of
      cyclopentenones employing a RhII-catalyzed, formal [4+1]-cycloaddition is
      described. A Rh2(S-TCPTTL)4-catalyzed cyclopropanation of a vinyl ketene with a
      disubstituted diazo compound initiates a stereoretentive, accelerated ring
      expansion to provide the cycloadduct in good to excellent yields and
      enantioselectivity.

PMID- 29844896
TI  - Reversible stapling of unprotected peptides via chemoselective methionine bis
      alkylation/dealkylation.
AB  - We have developed a general peptide macrocyclization strategy that involves a
      facile and chemoselective methionine bis-alkylation/dealkylation process. This
      method provides a straightforward and easy approach to generate cyclic peptides
      with tolerances of all amino acids (including Cys), variable loop sizes, and
      different linkers. The Met bis-alkylation we apply in this strategy yields two
      additional on-tether positive charges that could assist in the cellular uptake of
      the peptides. Notably, the bis-alkylated peptide could be reduced to release the
      original peptide both in vitro and within cellular environments. This strategy
      provides an intriguing and facile traceless post-peptide-synthesis modification
      with enhanced cellular uptakes. Peptides constructed with this method could be
      utilized to zero in on various protein targets or to achieve other goals, such as
      drug delivery.

PMID- 29844897
TI  - Bioresponsive and near infrared photon co-enhanced cancer theranostic based on
      upconversion nanocapsules.
AB  - Developing nanotheranostics responsive to tumor microenvironments has attracted
      tremendous attention for on-demand cancer diagnosis and treatment. Herein, a
      facile Mn-doping strategy was adopted to transform mesoporous silica coated
      upconversion nanoparticles (UCNPs) to yolk-like upconversion nanostructures which
      possess a tumor-responsive biodegradation nature. The huge internal space of the
      innovated nanocarriers is suitable for doxorubicin (DOX) storage, besides, the Mn
      doped shell is sensitive to the intratumoral acidity and reducibility, which
      enables shell biodegradation and further accelerates the breakage of Si-O-Si
      bonds within the silica framework. This tumor-responsive shell degradation is
      beneficial for realizing tumor-specific DOX release. Subsequently,
      polyoxometalate (POM) nanoclusters that can enhance photothermal conversion in
      response to the tumor reducibility and acidity were modified on the surface of
      the silica shell, thereby achieving NIR-enhanced shell degradation and also
      preventing premature DOX leakage. The as-produced thermal effect of the POM
      couples with the chemotherapy effect of the released DOX to perform a synergetic
      chemo-photothermal therapy. Additionally, the shell degradation brings size
      shrinkage to the nanocarriers, allowing faster nanoparticle diffusion and deeper
      tumor penetration, which is significant for improving theranostic outcomes. Also,
      the drastic decline of the red/green (R/G) ratio caused by the DOX release can be
      used to monitor the DOX release content through a fluorescence resonance energy
      transfer (FRET) method. The MRI effect caused by Mn release together with the
      MRI/CT/UCL imaging derived from Gd3+/Yb3+/Nd3+/Er3+ co-doped UCNPs under 808 nm
      laser excitation endow the nanosystem with multiple imaging capability, thus
      realizing imaging-guided cancer therapy.

PMID- 29844898
TI  - A highly integrated DNA nanomachine operating in living cells powered by an
      endogenous stimulus.
AB  - Synthetic molecular machines have received increasing attention because of their
      great ability to mimic natural biological motors and create novel modes of
      motion. However, very few examples have been implemented with real autonomous
      movement inside living cells, due to the challenges of the driving force and
      highly integrated system design. In this work, we report an elegant, highly
      integrated DNA nanomachine that can be powered by endogenous ATP molecules and
      autonomously operated inside living cells without any auxiliary additives. It
      assembles all components on a single gold nanoparticle (AuNP) including a hairpin
      locked swing arm encoding a start triggered by an intracellular target molecule
      and a two-stranded DNA track responding to the motion of the swing arm. When the
      intracellular target activates the nanomachine via the unlocking swing arm, the
      machine autonomously and progressively operates on the established DNA track via
      intramolecular toehold-mediated strand migration and internal ATP binding. This
      paper also demonstrates the machine's bioanalytical application for specific
      microRNA (miRNA) imaging in living cells.

PMID- 29844899
TI  - Lanthanide doping induced electrochemical enhancement of Na2Ti3O7 anodes for
      sodium-ion batteries.
AB  - Na2Ti3O7 is considered as a promising anode material for sodium ion batteries
      (SIBs) due to its excellent high-rate performance compared with hard carbons.
      However, the electrochemical performance of Na2Ti3O7 is heavily limited by its
      low electrical conductivity. In this study, we synthesized a series of lanthanide
      (Ln = La, Ce, Nd, Sm, Gd, Er, and Yb) doped microsized Na2Ti3O7 anode materials
      and systematically studied the electrochemical performance. Compared with
      pristine Na2Ti3O7, all the doped samples show superior electrochemical
      performance. Especially, the Yb3+ doped sample not only delivers a high
      reversible capacity of 89.4 mA h g-1 at 30C, but also maintains 71.6 mA h g-1 at
      5C after 1600 cycles, nearly twice that of pristine Na2Ti3O7. It is found for the
      first time that the enhancement in doped samples is attributed to the
      introduction of lanthanides which induces lattice distortion and oxygen
      vacancies.

PMID- 29844900
TI  - The role of P-wave dispersion in dystrophic and thalassemic cardiomyopathy.

PMID- 29844901
TI  - Definition of fields margins for palliative radiotherapy of pancreatic carcinoma.
AB  - The present study aimed to provide practical guidelines for palliative treatment
      of advanced carcinoma of the pancreas (CAP) with the 2D technique. Fifteen
      patients with locally advanced CAP consecutively treated with radiation therapy
      at the Radiation Oncology Center, Research and Care Foundation 'Giovanni Paolo
      II' (Campobasso, Italy) underwent computed tomography simulation in supine
      position. Definition of the clinical target volume (CTV) included the head and
      body of the pancreas, and the retropancreatic space. The planning target volume
      was defined by adding a margin of 14 mm to the CTV in the cranio-caudal direction
      and of 11 mm in radial direction. For each patient, 3 treatment plans were
      calculated using a cobalt source, 6 MV photons and 15 MV photons (box technique).
      Beams were drawn using the primary collimators without using multileaf
      collimators, and progressively optimized in order to respect the minimum dose
      (Dmin>90%) constraint. Once the final plan was achieved, distances of the fields
      edges from a set of reference points (bony or duodenal landmarks) were measured.
      Using this technique, 15 anterior-posterior and postero-anterior (AP-PA) beams
      and 15 pairs of lateral-lateral (LL) beams were defined for the different
      patients. Finally, the single minimal AP-PA and LL beams able to include the 15
      sets of AP-PA and LL beams were defined. The results of this analysis are
      reported in tabular form. Guidelines are provided for treatment based on cobalt
      unit or Linear accelerator (both 6 and 15 MV photons). This study provides
      information regarding field size and position. A dosimetric study has been
      planned to identify the dose to be administered with this technique taking into
      account current dose-volume constraints.

PMID- 29844902
TI  - Gene expression changes associated with chemotherapy resistance in Ewing sarcoma
      cells.
AB  - Ewing Sarcoma (ES) is a highly aggressive bone and soft tissue childhood cancer.
      The development of resistance to chemotherapy is common and remains the main
      cause of treatment failure. We herein evaluated the expression of genes
      associated with chemotherapy resistance in ES cell lines. A set of genes (CCAR1,
      TUBA1A, POLDIP2, SMARCA4 and SMARCB1) was data-mined for resistance against
      doxorubicin and vincristine, which are the standard drugs used in the treatment
      of patients with ES. The expression of each gene in SK-ES-1 ES cells was reported
      before and after exposure to a drug resistance-inducing protocol. There was a
      significant downregulation of CCAR1 and TUBA1A in doxorubicin-resistant cells,
      with low expression of TUBA1A in vincristine-resistant cells. By contrast,
      POLDIP2 was significantly upregulated in cells resistant to either drug, and the
      expression of the SMARCB1 and SMARCA4 genes was upregulated in doxorubicin
      resistant cells. These findings indicate that resistance to specific
      chemotherapeutic agents was accompanied by differential changes in gene
      expression in ES tumors.

PMID- 29844903
TI  - Adrenal collision tumor (parachordoma and ganglioneuroma): A case report.
AB  - Adrenal collision tumors (ACTs) are distinct tumors that occur simultaneously in
      the same adrenal gland and are very rare. We herein report the case of a 56-year
      old woman who was admitted to the hospital for medical imaging. The findings of
      the physical and laboratory examinations, including endocrine function, were
      unremarkable. Contrast-enhanced computed tomography of the abdomen revealed a
      28*20*33-mm mass in the left adrenal medial limb, for which a laparoscopic
      surgery was performed. Postoperative pathological examination revealed two
      distinct tumors, namely a parachordoma and a ganglioneuroma. To the best of our
      knowledge, and following a thorough literature search, this is the first report
      of coexisting parachordoma and ganglioneuroma in the same adrenal gland.

PMID- 29844904
TI  - Pseudomalignant myositis ossificans in the breast: A case report.
AB  - Myositis ossificans (MO) is characterized by abnormal heterotopic ossification
      formation, typically involving muscles, tendons, ligaments, fascia, and
      aponeurosis. It can be categorized into nonhereditary and hereditary types, with
      the latter being a distinct entity with a separate pathophysiology and treatment
      approach. The pathophysiology of MO formation remains to be fully elucidated. MO
      is most commonly observed in muscle tissue as a solitary lesion. The disease has
      been reported to occur in all ages, including the very young and in atypical
      locations, including hands, feet, ribs, head and neck. The present case report
      describes an unusual pseudomalignant form of MO in the breast. The authors
      discuss the clinical and morphological characteristics of the tumor and its
      treatment options.

PMID- 29844905
TI  - Primary pulmonary NK/T-cell lymphoma: A case report and literature review.
AB  - Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is an aggressive disease
      with poor prognosis. The lung is a relatively rare site of involvement. The
      current study presents a case of primary pulmonary ENKTL with fever and dyspnea,
      mimicking pneumonia and initially treated with empirical antibiotics. The patient
      demonstrated rapid deterioration and died shortly following diagnosis. To the
      best of our knowledge, large-scale investigations referring to primary pulmonary
      ENKTL are not available. As a result, the exact incidence and clinical features
      of primary pulmonary ENKTL are unknown. In the current report, a literature
      review is presented to discuss the clinical characteristics, diagnosis,
      treatment, and prognosis factors of this malignant disease.

PMID- 29844906
TI  - Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14)
      translocation: A case report.
AB  - t(11;14) translocation is one of the most common chromosomal abnormalities in
      plasma cell myeloma. The present case report presented a case of plasma cell
      myeloma with t(11;14) translocation, in which the plasma cells were small
      lymphoplasmacytoids in morphology with positive cluster of differentiation-20 and
      Cyclin D1 expression. These results led to initial diagnostic difficulties. The
      patient was refractory to bortezomib-based therapy, and responsive to
      vincristine, doxorubicin and dexamethasone. However, the prognostic value of
      t(11;14) in plasma cell myeloma remains to be determined. With recent advances in
      treatment options, physicians should be aware of the clinical and pathological
      characteristics of this translocation in plasma cell myeloma.

PMID- 29844907
TI  - Pattern of lymph node metastasis in thoracic esophageal squamous cell carcinoma
      with poor differentiation.
AB  - The aim of the present study was to explore the pattern of lymph node metastasis
      (LNM) in poorly-differentiated esophageal squamous cell carcinoma (pdESCC) and
      the implication of postoperative irradiation. A total of 690 patients with pdESCC
      were retrospectively investigated. The rates of intro-thoracic and extra-thoracic
      LNM in pdESCC were investigated and compared to previous research on ESCC en
      bloc. The comparison of the rates between pdESCC and ESCC were performed using
      the Cochran-Mantel-Haenszel test. The clinicopathological factors associated with
      LNM in pdESCC were analyzed by Chi-squared tests, and Fisher's exact test was
      used to assess the rate difference of extra-thoracic LNM. Logistic-regression
      analysis was used to explore risk factors associated with lymph node (LN)
      station. Results demonstrated that the distribution pattern of LNM in pdESCC was
      significantly different compared with that of ESCC (P<0.05). Univariate and
      multivariate analysis indicated that risk factors associated with LNM were depth
      and length (P<0.001 and P<0.001) and multivariate analysis also indicated that
      the location of the tumor (P=0.042) was a risk factor associated with LNM in
      pdESCC. Metastasis in the abdominal cavity was significantly higher than in the
      neck in the middle and lower thoracic pdESCC (both P<0.01). LN station 102 and 7
      for upper thoracic ESCC, 101 and 105 for middle thoracic ESCC, and 100 for lower
      thoracic ESCC were identified as high-risk stations for metastases in pdESCC
      compared to ESCC. Several parameters, including location and neck metastasis,
      were identified as risk factors of metastasis for the above sites, respectively.
      In conclusion, postoperative therapy should include more LN stations in pdESCC
      depending on risk factors of tumor metastasis individually.

PMID- 29844908
TI  - Diagnostic accuracy of T stage of gastric cancer from the view point of
      application of laparoscopic proximal gastrectomy.
AB  - The preoperative diagnosis of T stage is important in selecting limited
      treatments, such as laparoscopic proximal gastrectomy (LPG), which lacks the
      ability to palpate the tumor. Therefore, the present study examined the accuracy
      of preoperative diagnosis of the depth of tumor invasion in early gastric cancer
      from the view point of the indication for LPG. A total of 193 patients with cT1
      gastric cancer underwent LPG with gastrointestinal endoscopic examinations and a
      series of upper gastrointestinal radiographs. The patients with pT1 were
      classified into the correctly diagnosed group (163 patients, 84.5%), and those
      with pT2 or deeper were classified into the underestimated group (30 patients,
      15.5%). Factors that were associated with underestimation of tumor depth were
      analyzed. Tumor size in the underestimated group was significantly larger; the
      lesions were more frequently located in the upper third of the stomach and were
      more histologically diffuse, scirrhous, with infiltrative growth, and more
      frequent lymphatic and venous invasion. For upper third lesions, in univariate
      analysis, histology (diffuse type) was associated with underestimation of tumor
      depth. Multivariate analysis found that tumor size (>=20 mm) and histology
      (diffuse type) were independently associated with underestimation of tumor depth.
      gastric cancer in the upper third of the stomach with diffuse type histology and
      >20 mm needs particular attention when considering the application of LPG.

PMID- 29844909
TI  - Oncological outcomes classified according to metastatic lesions in the era of
      molecular targeted drugs for metastatic renal cancer.
AB  - Since the introduction of molecular targeted agents for the treatment of
      metastatic renal cell cancer (mRCC), several treatment outcomes, including those
      from our facilities, have been reported. However, the outcome of these drugs,
      classified by the metastatic organs, is not well known. The present study
      reported the treatment results of molecular-targeted agents as classified by the
      metastatic organ at Osaka City University Graduate School of Medicine. A total of
      180 consecutively treated patients who had received molecular targeted agents for
      metastatic renal cancer for 3 or more months were retrospectively analyzed. The
      overall survival was calculated and compared according to the Memorial Sloan
      Kettering Cancer Center (MSKCC) criteria, the number of metastatic organs, and
      metastatic lesions. The median overall survival of patients with mRCC treated by
      molecular targeted agents was 34 months. A significant difference in survival
      rate between groups was found according to the MSKCC criteria. Patients with
      single metastatic organ lived significantly longer compared with those with
      metastases in multiple organs. Patients with pancreatic metastasis had a good
      response to molecular targeted drugs. Pancreatic metastasis, the number of
      metastatic organs, and MSKCC criteria were independent risk factors for overall
      survival. Treatment of mRCC by molecularly targeted agents did not show any
      difference by metastatic organs except for the pancreas, although its efficacy
      depends on the number of metastatic organs and the MSKCC classification.

PMID- 29844910
TI  - Factors associated with late arrival of acute stroke patients to emergency
      department in Saudi Arabia.
AB  - Background: Tissue plasminogen activator within 4.5 h of onset is effective for
      acute ischemic stroke. However, only small proportion of patients is treated due
      to delayed presentation. We aimed to examine the factors associated with delays
      of stroke patients in Riyadh, Saudi Arabia. Methods: A cross-sectional survey was
      conducted at King Abdulaziz Medical City, Riyadh, Saudi Arabia, during a 6-month
      period. An interviewer administered structured questionnaire addressed to the
      acute stroke patients or their relatives was used to explore the factors
      associated with delayed arrival. Results: A total of 227 patients attending the
      emergency department were interviewed. The mean age was 60.4 +/- 15.6 years.
      Approximately 56.4% presented after 4.5 h of stroke onset. Factors associated
      with late arrival were being alone during the onset of stroke, not being
      transported in an ambulance, not knowing that they were experiencing a stroke,
      and residing outside the city of Riyadh. Conclusion: More than half of patients
      missed the golden hours for thrombolysis due to delayed presentation. Reasons
      include lack of knowledge, underuse of ambulance and difficult access to care.
      Urgent community-based interventions are needed to address these factors.

PMID- 29844911
TI  - End-of-life decision making by family caregivers of persons with advanced
      dementia: A literature review of decision aids.
AB  - Objectives: To investigate existing knowledge in the literature about end-of-life
      decision making by family caregivers of persons with dementia, focusing on
      decision aids for caregivers of persons with advanced dementia, and to identify
      gaps in the literature that can guide future research. Methods: A literature
      review through systematic searches in PubMed, CINAHL Plus with Full Text, and
      PsycINFO was conducted in February 2018; publications with full text in English
      and published in the past 10 years were selected in multiple steps. Results: The
      final sample included five decision aids with predominantly Caucasian
      participants; three of them had control groups, and three used audiovisual
      technology in presenting the intervention materials. No other technology was used
      in any intervention. Existing interventions lacked tailoring of information to
      caregivers' preferences for different types and amounts of information necessary
      to make decisions consistent with patients' values. Conclusion: Research is
      needed in exploring the use of technology in decision aids that could provide
      tailored information to facilitate caregivers' decision making. More diverse
      samples are needed.

PMID- 29844912
TI  - Adverse events of smoking cessation treatments (nicotine replacement therapy and
      non-nicotine prescription medication) and electronic cigarettes in the Food and
      Drug Administration Adverse Event Reporting System, 2004-2016.
AB  - Objectives: Several smoking cessation treatments (nicotine replacement therapy
      and non-nicotine prescription medication) and electronic cigarettes are widely
      used. We evaluated the adverse events related to smoking cessation treatments and
      electronic cigarettes in the US Food and Drug Administration Adverse Event
      Reporting System database. Methods: We analyzed reports of adverse events
      associated with smoking cessation treatment and electronic cigarettes terms dated
      between January 2004 and December 2016. We used the reporting odds ratio with 95%
      confidence intervals to detect a signal for each adverse event. Results: In
      total, 8,867,135 reports in the Food and Drug Administration Adverse Event
      Reporting System database were analyzed. The numbers of adverse events for
      nicotine replacement therapy (transdermal, buccal, oral, and respiratory
      administration) were 1673, 1016, 425, and 56, respectively. Nicotine replacement
      therapy (transdermal, buccal, and oral) demonstrated adverse events of nausea,
      nicotine dependence, and dizziness. For nicotine (transdermal) exposure, the top
      5 adverse events reported were nausea (149 cases, reporting odds ratio: 2.28 (95%
      confidence interval: 1.92-2.69)), dizziness (132 cases, reporting odds ratio:
      3.04 (95% confidence interval: 2.54-3.63)), application site erythema (108 cases,
      reporting odds ratio: 32.52 (95% confidence interval: 26.74-39.55)), headache (98
      cases, reporting odds ratio: 1.84 (95% confidence interval: 1.50-2.25)), and
      dyspnea (94 cases, reporting odds ratio: 1.93 (95% confidence interval: 1.57
      2.38)). Many cases of improper use of nicotine replacement therapies were
      reported. Nausea, depression, abnormal dreams, insomnia, and other adverse events
      were reported for varenicline. Insomnia, rash, anxiety, and dizziness were
      reported for bupropion. We observed electronic cigarettes-related adverse events
      such as dizziness, dyspnea, nausea, heart rate increased, and tremor. Conclusion:
      Our findings suggest that an association exists between nicotine-related adverse
      events and nicotine replacement therapy. Healthcare professionals should closely
      monitor smokers trying to quit nicotine use for the misuse of nicotine
      replacement therapy. These findings may be informative to healthcare
      professionals in order to improve the management of smoking cessation treatment.

PMID- 29844914
TI  - A Collet-Sicard syndrome due to internal carotid artery dissection associated
      with cerebral amyloid angiopathy-related inflammation.
AB  - Background: Cerebral amyloid angiopathy-related inflammation is a rare condition
      with approximately 100 reported cases. Its clinical manifestations are varied. We
      report here a novel presentation of this disease. Case presentation: A 61-year
      old Caucasian man presented with rapidly progressive paralysis of the IX, X, XI
      and XII right cranial nerves associated with right central facial nerve palsy.
      Brain computed tomography angiography and cerebral catheter angiography found a
      focal fusiform enlargement of the distal cervical portion of the right internal
      carotid artery, related to a pseudo-aneurysm suggesting an evolution of a
      dissection and intra-cranial vessel dysplasia. Brain magnetic resonance imaging
      showed multiple asymmetrical subcortical regions of hyperintensity on T2 fluid
      attenuated inversion recovery sequences. Punctiform cortical hyposignals on T2
      weighted gradient echo magnetic resonance imaging sequences were mostly congruent
      with the white matter hyperintensities. There was a decreased cerebral perfusion
      at the frontal hyperintense fluid-attenuated inversion recovery region.
      Spectrometry identified a lactate-lipid peak. A brain biopsy showed intravascular
      amyloid deposits. Corticosteroid therapy was initiated, leading to a dramatic
      improvement of both clinical condition and magnetic resonance imaging brain
      lesions. Conclusion: This case report suggests that extra-cranial vasculitis and
      dysplasia can exceptionally be found in patients satisfying cerebral amyloid
      angiopathy-related inflammation criteria.

PMID- 29844913
TI  - Clinical correlates and outcomes in a group of Puerto Ricans with systemic lupus
      erythematosus hospitalized due to severe infections.
AB  - Objective: Infections are a major cause of morbidity and mortality in systemic
      lupus erythematosus. Clinical outcomes of systemic lupus erythematosus patients
      hospitalized due to infections vary among different ethnic populations. Thus, we
      determined the outcomes and associated factors in a group of Hispanics from
      Puerto Rico with systemic lupus erythematosus admitted due to severe infections.
      Methods: Records of systemic lupus erythematosus patients admitted to the Adult
      University Hospital, San Juan, Puerto Rico, from January 2006 to December 2014
      were examined. Demographic parameters, lupus manifestations, comorbidities,
      pharmacologic treatments, inpatient complications, length of stay, readmissions,
      and mortality were determined. Patients with and without infections were compared
      using bivariate and multivariate analyses. Results: A total of 204 admissions
      corresponding to 129 systemic lupus erythematosus patients were studied. The mean
      (standard deviation) age was 34.7 (11.6) years; 90% were women. The main causes
      for admission were lupus flare (45.1%), infection (44.0%), and initial
      presentation of systemic lupus erythematosus (6.4%). The most common infections
      were complicated urinary tract infections (47.0%) and soft tissue infections
      (42.0%). In the multivariate analysis, patients admitted with infections were
      more likely to have diabetes mellitus (odds ratio: 4.20, 95% confidence interval:
      1.23-14.41), exposure to aspirin prior to hospitalization (odds ratio: 4.04, 95%
      confidence interval: 1.03-15.80), and higher mortality (odds ratio: 6.00, 95%
      confidence interval: 1.01-35.68) than those without infection. Conclusion: In
      this population of systemic lupus erythematosus patients, 44% of hospitalizations
      were due to severe infections. Patients with infections were more likely to have
      diabetes mellitus and higher mortality. Preventive and control measures of
      infection could be crucial to improve survival in these patients.

PMID- 29844915
TI  - Intellectual disability in patients with epilepsy with eyelid myoclonias.
AB  - We describe here the clinical outcome of four women with epilepsy with eyelid
      myoclonia (aged 21-53 years). All patients had an uneventful early history,
      normal physical growth and appearance and no comorbid sensory or motor disability
      and normal brain magnetic resonance imaging finding. Two women were moderately
      and one mildly intellectually disabled and one showed a low-average intelligence.
      The overall well-being of the patients was hampered by psychiatric or various
      somatic comorbidities and related psychosocial problems. The three women with an
      intellectual disability had been treated with narrow-spectrum antiepileptic drugs
      and one also with vigabatrin during childhood and adolescence. The patient with a
      low-average intelligence had been on broad-spectrum antiepileptic medication
      (i.e. valproate and ethosuximide) since the epilepsy diagnosis but she has had
      compliance problems. Based on these cases, the cognitive deficits in patients
      with epilepsy with eyelid myoclonia may occur more commonly than what has been
      thought hitherto. We discuss the role of narrow-spectrum antiepileptic drugs as a
      contributing factor to poor seizure control and an impaired intelligence.

PMID- 29844916
TI  - Multiple spontaneous hemorrhages after commencing warfarin therapy.
AB  - A 94 year-old Japanese woman with renal dysfunction was admitted to our hospital
      for congestive heart failure caused by atrial fibrillation with rapid ventricular
      response. Considering the risk of stroke, warfarin was commenced. However, she
      developed shock following brachial and retroperitoneal hemorrhage 4 days after
      starting warfarin despite not being over-anticoagulated. She recovered after
      receiving blood transfusion and intravenous vitamin K2. Bleeding during warfarin
      administration occurs more frequently in older individuals with lower glomerular
      filtration rates, especially within the first 30 days of warfarin treatment.
      Physicians should therefore check for unexpected bleeding after commencing
      warfarin and be prepared to reverse anticoagulation.

PMID- 29844917
TI  - Identification of a rare BMP pathway mutation in a non-syndromic human brain
      arteriovenous malformation via exome sequencing.
AB  - Brain arteriovenous malformations (AVMs) are abnormal connections between
      arteries and veins that can result in hemorrhagic stroke. A genetic basis for
      AVMs is suspected, and we investigated potential mutations in a 14-year-old girl
      who developed a recurrent brain AVM. Whole-exome sequencing (WES) of AVM lesion
      tissue and blood was performed accompanied by in silico modeling, protein
      expression observation in lesion tissue and zebrafish modeling. A stop-gain
      mutation (c.C739T:p.R247X) in the gene SMAD family member 9 (SMAD9) was
      discovered. In the human brain tissue, immunofluorescent staining demonstrated a
      vascular predominance of SMAD9 at the protein level. Vascular SMAD9 was markedly
      reduced in AVM peri-nidal blood vessels, which was accompanied by a decrease in
      phosphorylated SMAD4, a downstream effector protein of the bone morphogenic
      protein signaling pathway. Zebrafish modeling (Tg kdrl:eGFP) of the morpholino
      splice site and translation-blocking knockdown of SMAD9 resulted in abnormal
      cerebral artery-to-vein connections with morphologic similarities to human AVMs.
      Orthogonal trajectories of evidence established a relationship between the
      candidate mutation discovered in SMAD9 via WES and the clinical phenotype.
      Replication in similar rare cases of recurrent AVM, or even more broadly sporadic
      AVM, may be informative in building a more comprehensive understanding of AVM
      pathogenesis.

PMID- 29844918
TI  - Attitudes and Opinions of Canadian Nephrologists Toward Continuous Quality
      Improvement Options.
AB  - Background and objectives: A shift to holding individual physicians accountable
      for patient outcomes, rather than facilities, is intuitively attractive to policy
      makers and to the public. We were interested in nephrologists' attitudes to, and
      awareness of, quality metrics and how nephrologists would view a potential switch
      from the current model of facility-based quality measurement and reporting to
      publically available reports at the individual physician level. Design setting
      participants and measurements: The study was conducted using a web-based survey
      instrument (Online Appendix 1). The survey was initially pilot tested on a group
      of 8 nephrologists from across Canada. The survey was then finalized and e-mailed
      to 330 nephrologists through the Canadian Society of Nephrology (CSN) e-mail
      distribution list. The 127 respondents were 80% university based, and 33% were
      medical/dialysis directors. Results: The response rate was 43%. Results
      demonstrate that 89% of Canadian nephrologists are engaged in efforts to improve
      the quality of patient care. A minority of those surveyed (29%) had training in
      quality improvement. They feel accountable for this and would welcome the
      inclusion of patient-centered metrics of care quality. Support for public
      reporting as an effective strategy on an individual nephrologist level was 30%.
      Conclusions: Support for public reporting of individual nephrologist performance
      was low. The care of nephrology patients will be best served by the continued
      development of a critical mass of physicians trained in patient safety and
      quality improvement, by focusing on patient-centered metrics of care delivery,
      and by validating that all proposed new methods are shown to improve patient care
      and outcomes.

PMID- 29844919
TI  - Overview of Self-Management Resources Used by Canadian Chronic Kidney Disease
      Clinics: A National Survey.
AB  - Background: Chronic kidney disease (CKD) clinics across Canada provide tailored
      care for patients with CKD with an aim to slow progression and prevent
      complications. These clinics provide CKD self-management resources; however,
      there is limited information about what resources are being used by clinics. We
      undertook a survey of CKD clinics across Canada to identify self-management
      resources for adults aged 18 years and over with CKD categories 1 to 5 and not
      requiring dialysis or transplant. Objective: To identify and collate self
      management resources (eg, strategies, tools, educational materials) used by CKD
      clinics across Canada for adults with CKD (categories 1 to 5, not requiring
      kidney replacement therapy). Design: Self-administered, semistructured electronic
      survey. Setting participants: Canadian CKD clinics with previously identified
      contact information. Methods and measurements: We contacted 57 CKD English
      speaking clinics and invited them to complete an online survey. The survey was
      available from October 2016 to January 2017 and consisted of 17 questions
      regarding the use and attributes of self-management resources including topic,
      delivery format, provider, target population, where the intervention was
      provided, and resource languages. Results: Forty-four clinics (77%) completed the
      survey. The most common topic was modality education provided in print format, by
      nurses. The most frequently used resource was the Kidney Foundation of Canada
      (KFOC) Living With Kidney Disease manual. We also identified that the majority of
      resources were available in English, targeting both patients and caregivers in
      the outpatient setting. Limitations: Our survey included Canadian adult CKD
      clinics, which may not be generalizability to other settings, such as care of
      people with CKD in primary care. Conclusions: Adult CKD clinics across Canada
      provide some similar resources, but also provide many different self-management
      resources. Even though some of the same resources were used by multiple clinics,
      the way they were provided them (ie, provider, location, delivery format) varied
      by the individual clinics. Knowledge of self-management resources currently
      provided in CKD clinics, along with synthesis of the literature and patient
      preferred self-management strategies, will inform the design and development of a
      novel self-management intervention that is patient-centric and adheres to the
      principles of self-management.

PMID- 29844920
TI  - Aggregatibacter actinomycetemcomitans H-NS promotes biofilm formation and alters
      protein dynamics of other species within a polymicrobial oral biofilm.
AB  - Aggregatibacter actinomycetemcomitans is a Gram-negative organism, strongly
      associated with aggressive forms of periodontitis. An important virulence
      property of A. actinomycetemcomitans is its ability to form tenacious biofilms
      that can attach to abiotic as well as biotic surfaces. The histone-like (H-NS)
      family of nucleoid-structuring proteins act as transcriptional silencers in many
      Gram-negative bacteria. To evaluate the role of H-NS in A. actinomycetemcomitans,
      hns mutant derivatives of serotype a strain D7S were generated. Characteristics
      of the hns mutant phenotype included shorter and fewer pili, and substantially
      lower monospecies biofilm formation relative to the wild type. Furthermore, the
      D7S hns mutant exhibited significantly reduced growth within a seven-species oral
      biofilm model. However, no apparent difference was observed regarding the numbers
      and proportions of the remaining six species regardless of being co-cultivated
      with D7S hns or its parental strain. Proteomics analysis of the strains grown in
      monocultures confirmed the role of H-NS as a repressor of gene expression in A.
      actinomycetemcomitans. Interestingly, proteomics analysis of the multispecies
      biofilms indicated that the A. actinomycetemcomitans wild type and hns mutant
      imposed different regulatory effects on the pattern of protein expression in the
      other species, i.e., mainly Streptococcus spp., Fusobacterium nucleatum, and
      Veillonella dispar. Gene ontology analysis revealed that a large portion of the
      differentially regulated proteins was related to translational activity. Taken
      together, our data suggest that, apart from being a negative regulator of protein
      expression in A. actinomycetemcomitans, H-NS promotes biofilm formation and may
      be an important factor for survival of this species within a multispecies
      biofilm.

PMID- 29844921
TI  - Lipid analysis of Eimeria sporozoites reveals exclusive phospholipids, a
      phylogenetic mosaic of endogenous synthesis, and a host-independent lifestyle.
AB  - Successful inter-host transmission of most apicomplexan parasites requires the
      formation of infective sporozoites within the oocysts. Unlike all other infective
      stages that are strictly intracellular and depend on host resources, the
      sporozoite stage develops outside the host cells, but little is known about its
      self-governing metabolism. This study deployed Eimeria falciformis, a parasite
      infecting the mouse as its natural host, to investigate the process of
      phospholipid biogenesis in sporozoites. Lipidomic analyses demonstrated the
      occurrence of prototypical phospholipids along with abundant expression of at
      least two exclusive lipids, phosphatidylthreonine (PtdThr) and inositol
      phosphorylceramide with a phytosphingosine backbone, in sporozoites. To produce
      them de novo, the parasite harbors nearly the entire biogenesis network, which is
      an evolutionary mosaic of eukaryotic-type and prokaryotic-type enzymes. Notably,
      many have no phylogenetic counterpart or functional equivalent in the mammalian
      host. Using Toxoplasma gondii as a gene-tractable surrogate to examine Eimeria
      enzymes, we show a highly compartmentalized network of lipid synthesis spread
      primarily in the apicoplast, endoplasmic reticulum, mitochondrion, and Golgi
      complex. Likewise, trans-genera complementation of a Toxoplasma mutant with the
      PtdThr synthase from Eimeria reveals a convergent role of PtdThr in fostering the
      lytic cycle of coccidian parasites. Taken together, our work establishes a model
      of autonomous membrane biogenesis involving significant inter-organelle
      cooperation and lipid trafficking in sporozoites. Phylogenetic divergence of
      certain pathways offers attractive drug targets to block the sporulation and
      subsequent transmission. Not least, our results vindicate the possession of an
      entire de novo lipid synthesis network in a representative protist adapted to an
      obligate intracellular parasitic lifestyle.

PMID- 29844923
TI  - Foreword.

PMID- 29844922
TI  - Transcriptional timing and noise of yeast cell cycle regulators-a single cell and
      single molecule approach.
AB  - Gene expression is a stochastic process and its appropriate regulation is
      critical for cell cycle progression. Cellular stress response necessitates
      expression reprogramming and cell cycle arrest. While previous studies are mostly
      based on bulk experiments influenced by synchronization effects or lack temporal
      distribution, time-resolved methods on single cells are needed to understand
      eukaryotic cell cycle in context of noisy gene expression and external
      perturbations. Using smFISH, microscopy and morphological markers, we monitored
      mRNA abundances over cell cycle phases and calculated transcriptional noise for
      SIC1, CLN2, and CLB5, the main G1/S transition regulators in budding yeast. We
      employed mathematical modeling for in silico synchronization and for derivation
      of time-courses from single cell data. This approach disclosed detailed
      quantitative insights into transcriptional regulation with and without stress,
      not available from bulk experiments before. First, besides the main peak in G1 we
      found an upshift of CLN2 and CLB5 expression in late mitosis. Second, all three
      genes showed basal expression throughout cell cycle enlightening that
      transcription is not divided in on and off but rather in high and low phases.
      Finally, exposing cells to osmotic stress revealed different periods of
      transcriptional inhibition for CLN2 and CLB5 and the impact of stress on cell
      cycle phase duration. Combining experimental and computational approaches allowed
      us to precisely assess cell cycle progression timing, as well as gene expression
      dynamics.

PMID- 29844924
TI  - Erratum to: Impact of Exercise Training on Peak Oxygen Uptake and its
      Determinants in Heart Failure with Preserved Ejection Fraction.
AB  - [This corrects the article DOI: 10.15420/cfr.2016:16:2.].

PMID- 29844925
TI  - Decompression for botulinum toxin-exacerbated cervical myeloradiculopathy in the
      setting of congenital stenosis and Arnold-Chiari I malformation.
AB  - Introduction: We present a case describing the management of a woman with severe,
      functionally limiting cervical myeloradiculopathy in the setting of congenital
      cervical canal stenosis and Arnold-Chiari I malformation. Case presentation: The
      subject is a 57-year-old woman with prior anterior cervical discectomy and fusion
      who presented with left-sided neck pain associated with radiculopathy, migraine,
      gait incoordination, and cervical dystonia. Cervical stenosis and Chiari
      malformation were confirmed using MRI. Conservative management with botulinum
      toxin, oral muscle relaxants, and cervical brace led to gradual exacerbation of
      symptoms. Due to failure of conservative management, surgical decompression with
      C3-C6 posterior laminoplasty was performed, resulting in complete resolution of
      all symptoms and markedly improved quality of life. Discussion: This case reports
      a severe and nonspecific presentation of cervical myeloradiculopathy. Surgery for
      cervical myeloradiculopathy is controversial, and conservative therapy is
      initially preferred. However, in this case, conservative treatments likely led to
      paraspinal weakness, cervical hypermobility, and biomechanical instability,
      resulting in exacerbation of symptoms. Stretch/shear forces have been postulated
      to accelerate cervical myelopathy, and excessive cervical instability and range
      of motion are significant predictors of deterioration. In this case, surgical
      decompression with posterior cervical laminoplasty after 1 year of conservative
      management yielded significant pain relief and functional restoration, indicating
      the utility of this procedure even in the presence of Arnold-Chiari I
      malformation. This case illustrates that decompression can be effective for
      refractory cervical myeloradiculopathy associated with Chiari malformation,
      congenital stenosis, and prior anterior instrumentation, and highlights the
      potential risks of prolonged conservative management.

PMID- 29844926
TI  - Asymptomatic tachycardia and acute pulmonary embolism in a case of tuberculosis
      spondylodiscitis.
AB  - Introduction: Tachycardia, or elevated heart rate is one of the important
      clinical parameters considered when diagnosing pulmonary embolism (PE) based on
      Wells' criteria. However, tachycardia is not highly specific and commonly
      presents in many other conditions. Case presentation: A 29-year-old female with
      incomplete paraplegia secondary to tuberculosis (TB) spondylodiscitis presented
      with asymptomatic sinus tachycardia. The related medical conditions, including
      anaemia, acute coronary syndrome, hyperthyroidism and other infective causes had
      been ruled out. Deep venous thrombosis was not on the list of differentials as
      she showed improvements in neurological and mobility functions with no clinical
      signs of calf pain or swelling. She had moderate risk of acute PE based on Wells'
      criteria with positive D-dimer testing and computed tomography pulmonary
      angiography (CTPA) showing thrombus formation in the left-ascending pulmonary
      artery. Discussion: Acute PE may present solely with asymptomatic sinus
      tachycardia in TB spondylodiscitis. This caveat should provide a high index of
      suspicion to prevent delay in diagnosis and prevention of more sinister
      complications. Early stratification based on Wells' criteria for a possible
      diagnosis of acute PE is proven to be a useful approach in conjunction with
      clinical features.

PMID- 29844927
TI  - Delayed diagnosis of traumatic gunshot wound Brown-Sequard-plus syndrome due to
      associated brachial plexopathy.
AB  - Introduction: Brown-Sequard Syndrome (BSS) is one of the rarest incomplete spinal
      cord syndromes. The combination of injuries to peripheral nerves and the central
      nervous system result in an array of symptoms that can result in overlapping
      clinical presentations and delayed diagnosis. Early detection of spinal cord
      injury in patients with peripheral nerve injury has been observed to have a
      positive effect on outcomes. Case presentation: This report discusses the case of
      a 29-year-old male patient with Brown-Sequard-Plus Syndrome (BSPS) and Brachial
      Plexopathy (BP) secondary to gunshot wound in the left inferior neck. The patient
      was found initially with left hemibody weakness. A chest CT Scan demonstrated a
      fracture of the left T2 transverse process. Imaging studies of the spinal cord
      were not performed in the acute setting. Evaluation in an outpatient setting 3
      weeks later showed significant left upper extremity weakness with improvement of
      left lower extremity strength. Also present were loss of pain and temperature
      sensation on the right side below the T2 dermatome level. A cervico-thoracic MRI
      was requested and revealed a T2 level spinal cord contusion. Electrodiagnostic
      studies confirmed a lower trunk left BP. Discussion: The patient was diagnosed
      with BSPS and associated left lower trunk BP. To our knowledge, this is the first
      reported case of a concomitant BSPS and BP secondary to a gunshot wound. Delayed
      diagnosis of BSPS may occur in a trauma setting underlying the importance of a
      detailed history and physical examination for favorable outcomes.

PMID- 29844928
TI  - International Spinal Cord Society (ISCoS) database: Asian Spinal Cord Network
      (ASCoN) Pilot Project [IDAPP].
AB  - Study design: Global mapping project of ISCoS for traumatic spinal cord injury (T
      SCI) highlighted paucity of data from low and middle income countries (LMICs).
      Recognizing this gap, IDAPP study of one year duration was proposed as the first
      step to develop an International SCI database. Objectives: Primary objective was
      to assess database variables, processes involved and web platform for their
      suitability with a view to provide guidance for a large scale global project.
      Secondary objective was to capture demographic and selected injury/safety data on
      patients with T-SCI with a view to formulate prevention strategies. Setting: Nine
      centers from Asia. Methods: All patients with T-SCI admitted for first time were
      included. International SCI Core Data Set and especially compiled Minimal Safety
      Data Set were used as data elements. Questionnaire was used for feedback from
      centers. Results: Results showed relevance and appropriateness of processes, data
      variables and web platform of the study. Ease of entering and retrieval of data
      from web platform was confirmed. Cost of one year IDAPP study was USD 7780. 975
      patients were enrolled. 790 (81%) were males. High falls (n = 513, 52%) as a
      cause and complete injuries (n = 547, 56%) were more common. There was a higher
      percentage of thoracic and lumbar injuries (n = 516, 53%). Conclusions: The study
      confirms that establishing the SCI database is possible using the variables,
      processes and web platform of the pilot study. It also provides a low cost
      solution. Expansion to other centers/regions and including non-traumatic SCI
      would be the next step forward.

PMID- 29844929
TI  - Spinal cord injured women's treatment of breast carcinoma: alert to
      complications.
AB  - Introduction: Women with spinal cord injury (SCI) and who develop breast cancer
      are a vulnerable and potentially overlooked population. They experience risk
      factors owing to decreased mobility and are at risk for unique complications from
      their oncologic treatment. Case presentation: A 54-year-old woman who suffered a
      T6 AIS A traumatic SCI in 1981, who was diagnosed 32 years later with estrogen
      receptor and progesterone receptor positive and human epidermal growth factor
      receptor 2-negative invasive ductal carcinoma. During the course of her
      chemotherapy, she experienced several complications, including reflexive
      diaphoresis, urinary tract infection, leukopenia, anemia, dehydration, and
      weakness. These contributed to the development of a stage 4 ischial pressure
      sore, which required complex treatment. Discussion: There is a paucity of
      literature examining the complications of chemotherapy that may be unique to
      those with SCI. Physiatrists will be seeing more women undergoing oncologic care,
      as this population of patients ages. A multidisciplinary approach that takes into
      account the pathophysiologic changes associated with SCI is crucial to understand
      and prevent complications that could affect their outcomes and contribute to
      increased cost in a value-based health-care system.

PMID- 29844930
TI  - Macrophage inducible nitric oxide synthase circulates inflammation and promotes
      lung carcinogenesis.
AB  - Human lung squamous cell carcinoma (SCC) is highly associated with increased
      pulmonary macrophage infiltration. Previously, we showed that marked pulmonary
      infiltrating macrophages were required for spontaneous lung SCC development in a
      mouse model (L-IkkalphaKA/KA , KA/KA) that resembles human lung SCC.
      Interestingly the lung SCC-associated macrophages specifically express elevated
      inducible nitric oxide synthase (NOS2). However, the role of macrophage NOS2 in
      lung carcinogenesis has not been explored. Here, we show that NOS2 ablation
      inhibits macrophage infiltration, fibrosis, and SCC development in the lungs of
      KA/KA mice. Macrophage NOS2 was found to circulate inflammation and enhance
      macrophage migration and survival. NOS2 promotes foamy macrophage formation
      characterized with impaired lipid metabolism. NOS2 null bone marrow
      transplantation reduces foamy macrophage numbers and carcinogenesis in KA/KA
      chimaeras. This finding sheds light on a new mechanism by which macrophage NOS2
      increases pulmonary inflammatory responses and macrophage survival and impairs
      macrophage lipid metabolism, thereby promoting lung SCC formation.

PMID- 29844931
TI  - Dasatinib reduces 5-Fu-triggered apoptosis in colon carcinoma by directly
      modulating Src-dependent caspase-9 phosphorylation.
AB  - Preclinical data have revealed the inhibitory effect of dasatinib on colon
      cancer. However, a combination of dasatinib and conventional chemotherapy has
      failed to show any meaningful outcome in a series of clinical trials. We,
      therefore, wondered whether Src kinase inhibitors were suitable for treating
      colon cancer in combination with chemotherapy drugs. This study was designed to
      explore whether dasatinib disturbed 5-Fu-triggered apoptosis in colon carcinoma.
      As a result, we established that Src was able to directly phosphorylate caspase-9
      at tyrosine 251, leading to elevated caspase-9 activity. Dasatinib dramatically
      decreased 5-Fu triggered apoptosis in colon carcinoma via suppression of Src
      activation. Our findings may have partially explained why dasatinib combined with
      FOLFOX failed to show a meaningful clinical response in mCRC.

PMID- 29844932
TI  - Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5
      mediated Akt/NF-kappaB signaling pathway.
AB  - The chemokine, CCL5, is a key mediator for the recruitment of immune cells into
      tumors and tissues. Akt/NF-kappaB signaling is significantly activated by CCL5.
      However, the role of NF-kappaB inactivation in apoptosis induced by negative
      regulation of CCL5 remains unclear. Here, we analyzed the effect of cordycepin on
      NF-kappaB activity in SKOV-3 cells and found that cordycepin-mediated inhibition
      of NF-kappaB signaling induced apoptosis in SKOV-3 cells via the serial
      activation of caspases. In addition, immune-blotting analysis showed that CCL5 is
      highly expressed in SKOV-3 cells. In addition to activating caspases, we show
      that, cordycepin prevents TNF-alpha-induced increase in CCL5, Akt, NF-kappaB, and
      c-FLIPL activation and that CCL5 siRNA could inhibit Akt/NF-kappaB signaling.
      Moreover, cordycepin negatively regulated the TNF-alpha-mediated IkappaB/NF
      kappaB pathway and c-FLIPL activation to promote JNK phosphorylation, resulting
      in caspase-3 activation and apoptosis. Also, we show that c-FLIPL is rapidly lost
      in NF-kappaB activation-deficient. siRNA mediated c-FLIP inhibition increased
      JNK. SP600125, a selective JNK inhibitor, downregulated p-JNK expression in
      cordycepin-treated SKOV-3 cells, leading to suppression of cordycepin-induced
      apoptosis. Thus, these results indicate that cordycepin inhibits CCL5-mediated
      Akt/NF-kappaB signaling, which upregulates caspase-3 activation in SKOV-3 cells,
      supporting the potential of cordycepin as a therapeutic agent for ovarian cancer.

PMID- 29844934
TI  - The relationship between splenic length in healthy children from the Eastern
      Anatolia Region and sex, age, body height and weight.
AB  - Purposes: The normal limits of spleen size must be known in order for
      pathological changes to be noticed. The aim of this retrospective study is to
      determine the normal limits of spleen size in healthy children and to reveal
      their relation to sex, age, body height and weight. Patients and methods: Three
      hundred and ten children (150 girls and 160 boys) between 0-16 years of age in
      Eastern Anatolia Region who had normal spleen ultrasound appearances were
      included in this study. The greatest longitudinal distance of the spleen from the
      dome to the tip (splenic length) measured at the hilum in the coronal plane was
      obtained by ultrasonography. Results: There was no significant difference between
      the sexes in children. Also, no statistically significant differences were found
      between the two sexes in any age group for splenic length (t-test, p > 0.05).
      Therefore, all data were rearranged without being separated according to sex. The
      correlation analysis has shown a positive and significant correlation between
      splenic length and age, body height, and weight, with high correlation
      coefficients (r > 0.80). Splenic length showed the strongest correlation with
      body height. Conclusion: In children clinically suspected of organomegaly,
      splenic length can be used to assess organ size. The presented data can be
      applied to routine ultrasonography examinations.

PMID- 29844935
TI  - Cartilaginous compression of the liver - clinical and ultrasonographic aspects.
AB  - Introduction: The musculocartilaginous complex is a structure composed of
      cartilaginous, osseous and muscular elements, which is located at the
      thoracoabdominal junction, at the level of the right costal arch. Aim: To
      determine the ultrasonographic characteristics of this complex under normal
      conditions as well as to demonstrate its effects on the liver depending on the
      constitutional body built, respiratory phase and patient's body position.
      Materials and methods: All abdominal ultrasound scans were performed between 2006
      and 2015. A total of 1000 patients (566 females and 434 males aged between 35 and
      82 years, mean age 52 years), who had no significant upper abdominal pathologies
      identified based on clinical and imaging data, were enrolled for the analysis. In
      addition to standard internal organ assessment, we also attempted to identify the
      symptoms of hepatic compression by the musculocartilaginous complex. We used 3-6
      MHz convex and 7-12 MHz linear transducers. The degree of musculocartilaginous
      compression of the liver was assessed during breathing in supine and sitting
      position, as well as with trunk inclined forward. Results: The study showed that
      musculocartilaginous compression of the liver mostly affects females (96%) with
      leptosomatic body build. The complex compressing the liver shows a heterogeneous
      echostructure. Increased hepatic compression was observed during exhalation, in a
      sitting position and with trunk inclined forward. Conclusions: Cartilaginous
      compression of the liver depends on body built and patient's body position. The
      musculocartilaginous complex may cause focal or segmental compression of the
      hepatic parenchyma, causing pain in the right upper abdomen in some patients.

PMID- 29844933
TI  - miRNAs reshape immunity and inflammatory responses in bacterial infection.
AB  - Pathogenic bacteria cause various infections worldwide, especially in
      immunocompromised and other susceptible individuals, and are also associated with
      high infant mortality rates in developing countries. MicroRNAs (miRNAs), small
      non-coding RNAs with evolutionarily conserved sequences, are expressed in various
      tissues and cells that play key part in various physiological and pathologic
      processes. Increasing evidence implies roles for miRNAs in bacterial infectious
      diseases by modulating inflammatory responses, cell penetration, tissue
      remodeling, and innate and adaptive immunity. This review highlights some recent
      intriguing findings, ranging from the correlation between aberrant expression of
      miRNAs with bacterial infection progression to their profound impact on host
      immune responses. Harnessing of dysregulated miRNAs in bacterial infection may be
      an approach to improving the diagnosis, prevention and therapy of infectious
      diseases.

PMID- 29844936
TI  - The sonoanatomy of lumbar erector spinae and its iliac attachment - the potential
      substrate of the iliac crest pain syndrome, an ultrasound study in healthy
      subjects.
AB  - Background: Iliac crest pain syndrome is a regional pain syndrome that has been
      identified in many patients with low back pain. Based on anatomical studies, it
      was suggested that the potential substrate of this syndrome might be the enthesis
      of the erector spinae muscle at the posterior medial iliac crest. As there have
      been no imaging studies of this important enthesis, our aim was to assess its
      characteristics by ultrasound. Methods: Erector spinae enthesis was first studied
      in a cadaver. Then its characteristics were recorded in 25 healthy volunteers
      (median age: 28.92, SD: 5.31, mean Body Mass Index 22.61, SD: 3.38), with Esaote
      My Lab 7 machine using linear transducer (4-13 MHz). Results: The cadaver study
      confirmed the attachment of a substantial part of erector spinae to a well
      defined region on the medial posterior iliac crest. The US study in the
      volunteers consistently showed the entheses as typical hyperechoic fibrillar
      structures, slightly oblique to the skin in the longitudinal plane and attaching
      to the iliac crest. In the transverse plane, the entheses were seen as oval,
      densely dotted structures in contact with the superior edge of posterior superior
      iliac spine. Their mean thickness (4.9 +/- 0.6 and 5.2 +/- 0.7 mm longitudinally;
      4.3 +/- 0.6 and 4.4 +/- 0.7 mm transversely), maximum width (16.3 +/- 2.8 and
      15.7 +/- 2.3 mm) and depth (10.8 +/- 7.3 and 10.6 +/- 6.2 mm) on the left and
      right side, respectively, as well as their echostructure were recorded and
      described. Conclusions: The erector spinae entheses could be assessed in detail
      by ultrasound, thus their pathological transformation associated with iliac crest
      pain syndrome could be identified.

PMID- 29844937
TI  - Utility of Doppler parameters at 36-42 weeks' gestation in the prediction of
      adverse perinatal outcomes in appropriate-for-gestational-age fetuses.
AB  - Aim: To investigate the potential value of Doppler ultrasound and to assess
      cerebroplacental ratio (CPR) in the prediction of adverse perinatal outcome
      defined as Apgar score < 7 at 1 minute. Material and methods: This was a
      retrospective cross-sectional study in selected pregnant women undergoing an
      ultrasound examination between 36 and 42 weeks of gestation. We measured
      estimated fetal weight (EFW), mean umbilical artery pulsatility index (UA PI),
      mean middle cerebral artery pulsatility index (MCA PI), CPR, and Apgar score in 1
      minute. Multiples of medians (MoM) were calculated for MCA PI and UA PI. Results:
      The study group consisted of 446 women, 236 were primipara and 210 were
      multipara. The average age was 29.6 years (range 16-46 years). The average week
      of delivery is 39.5 weeks of gestation (range 36-42). Mean MCA PI and UA PI were
      1.3 (0.1-2.45) and 0.8 (0.39-1.66), respectively. The mean values were 1.03 (0.1
      1.9) for MCA PI MoM and 1.04 (0.5-2.1) for UA PI MoM. Primiparas had lower values
      of MCA PI (1.27 vs. 1.34), MCA PI MoM (1.00 vs. 1.05), CPR (1.62 vs. 1.73), EFW
      (3479.53 g vs. 3579.25 g) and birth weight (3513.50 g vs. 3617.79 g). For CPR cut
      off point of 1.08: sensitivity was (0.945), specificity 0.1, positive predictive
      values 0.979, negative predictive values 0.04 and accuracy 0.926. The ROC curves
      for CPR were: area under the curve was 0.52 at CI 95% (0.342-0.698), p = 0.8271.
      Conclusion: Screening in pregnancies with appropriate-for-gestational-age fetuses
      at 36-42 weeks of gestation using Doppler parameters is not useful in the
      prediction of adverse perinatal outcomes like an Apgar score < 7 at 1 minute.

PMID- 29844938
TI  - Diagnostic accuracy of sonoelastography in different diseases.
AB  - The objective of this study was to evaluate the diagnostic accuracy of
      sonoelastography in patients of primary and secondary health care settings.
      Google scholar, PubMed, Medline, Medscape, Wikipedia and NCBI were searched in
      October 2017 for all original studies and review articles to identify the
      relevant material. Two reviewers independently selected articles for evaluation
      of the diagnostic accuracy of sonoelastography in different diseases based on
      titles and abstracts retrieved by the literature search. The accuracy of
      sonoelastography in different diseases was used as the index text, while B-mode
      sonography, micro pure imaging, surgery and histological findings were used as
      reference texts. Superficial lymph nodes, neck nodules, malignancy in thyroid
      nodules, benign and malignant cervical lymph nodes, thyroid nodules, prostate
      carcinoma, benign and malignant breast abnormalities, liver diseases, parotid and
      salivary gland masses, pancreatic masses, musculoskeletal diseases and renal
      disorders were target conditions. The data extracted by the two reviewers
      concerning selected study characteristics and results were presented in tables
      and figures. In total, 46 studies were found for breast masses, lymph nodes,
      prostate carcinoma, liver diseases, salivary and parotid gland diseases,
      pancreatic masses, musculoskeletal diseases and renal diseases, and the overall
      sensitivity of sonoelastography in diagnosing all these diseases was 83.14% while
      specificity was 81.41%. This literature review demonstrates that sonoelastography
      is characterized by high sensitivity and specificity in diagnosing different
      disorders of the body.

PMID- 29844939
TI  - Clinical applications of spleen ultrasound elastography - a review.
AB  - In the last few years, notable technical progress has taken place in ultrasound
      elastography. Qualitative methods have been replaced by quantitative ones, such
      as: transient elastography, acoustic radiation force impulse and shear wave
      elastography. Owing to the fact that the spleen is superficially located, it is
      possible to obtain reliable measuring accuracy of its hardness using
      sonoelastography. Lately, many researchers have been investigating how spleen
      elasticity changes in patients infected with hepatitis B virus or hepatitis C
      virus and in patients suffering from liver fibrosis, portal hypertension,
      esophageal varices or myelofibrosis. In this article, we review the role and
      current status of accessible qualitative ultrasound elastography methods,
      including recent advances in the evaluation of spleen stiffness and its clinical
      utility. As study results demonstrate, spleen stiffness correlates with liver
      fibrosis and is helpful in determining the level of fibrosis in the METAVIR
      scoring system. In patients infected with hepatitis B virus or hepatitis C virus,
      spleen stiffness increases even when liver elasticity remains unaltered.
      Furthermore, it is useful in diagnosing portal hypertension or predicting
      existence of esophageal varices. Moreover, in patients suffering from biliary
      atresia after Kasai portoenterostomy, spleen sonoelastography may be helpful in
      selecting patients for liver transplantation as well as for choosing the best
      strategy for portal vein reconstruction before liver transplantation. In
      myelofibrosis, spleen stiffness correlates with bone marrow fibrosis and may be
      used to assess the response to treatment. Spleen sonoelastography is also useful
      in the monitoring of transjugular intrahepatic portosystemic shunt function.

PMID- 29844940
TI  - Diabetic foot syndrome: Charcot arthropathy or osteomyelitis? Part I: Clinical
      picture and radiography.
AB  - One of significant challenges faced by diabetologists, surgeons and orthopedists
      who care for patients with diabetic foot syndrome is early diagnosis and
      differentiation of bone structure abnormalities typical of these patients, i.e.
      osteitis and Charcot arthropathy. In addition to clinical examination, the
      patient's medical history and laboratory tests, imaging plays a significant role.
      The evaluation usually begins with conventional radiographs. In the case of
      osteomyelitis, radiography shows osteopenia, lytic lesions, cortical destruction,
      periosteal reactions as well as, in the chronic phase, osteosclerosis and
      sequestra. Neurogenic arthropathy, however, presents an image resembling rapidly
      progressing osteoarthritis combined with aseptic necrosis or inflammation. The
      image includes: bone destruction with subluxations and dislocations as well as
      pathological fractures that lead to the presence of bone debris, osteopenia and,
      in the later phase, osteosclerosis, joint space narrowing, periosteal reactions,
      grotesque osteophytes and bone ankylosis. In the case of an unfavorable course of
      the disease and improper or delayed treatment, progression of these changes may
      lead to significant foot deformity that might resemble a "bag of bones".
      Unfortunately, radiography is non-specific and frequently does not warrant an
      unambiguous diagnosis, particularly in the initial phase preceding bone
      destruction. For these reasons, alternative imaging methods, such as magnetic
      resonance tomography, scintigraphy, computed tomography and ultrasonography, are
      also indicated.

PMID- 29844941
TI  - Current knowledge on the use of ultrasound measurements of fetal soft tissues for
      the assessment of pregnancy development.
AB  - Ultrasonography, with its detailed imaging of the fetus, is very widely used in
      obstetrics. The primary aim of ultrasound scanning in pregnancy is to limit the
      risk of obstetric complications by early detection of abnormalities, such as
      intrauterine growth restriction and macrosomia. Currently, morphometric formulae
      are used for estimating fetal weight. They utilize basic biometric parameters.
      However, Hadlock formula, used for fetal weight estimation, has an error rate of
      20%. For this reason, researchers all over the world have been looking for other
      sonographic parameters correlating with fetal weight, with a higher predictive
      value. The current scientific reports indicate that new sonographic parameters,
      such as soft tissue thickness values, are useful for fetal weight assessment. The
      measurements can be conducted in various parts of the fetus's body, e.g. thigh,
      upper arm, abdomen or the subscapular area. Different types of measurements are
      characterized by different levels of correlation with other sonographic and
      anthropometric parameters as well as body mass and gestational age. Based on the
      reports, numerous studies proposing new fetal weight calculation formulae have
      been produced. Apart from soft tissue, some more advanced and detailed
      measurements are taken, such as those involving adipose and lean tissue or using
      three-dimensional ultrasound (3D), for determining fetal weight. Ultrasound
      measurement of subcutaneous tissue thickness in various parts of the body may
      prove to be a strong predictor of fetal weight, which is useful for sonographic
      assessment of pregnancy.

PMID- 29844942
TI  - Cesarean scar pregnancy - a new challenge for obstetricians.
AB  - Diagnosis and treatment of ectopic cesarean scar pregnancy has become a challenge
      for contemporary obstetrics. With an increase in the number of pregnancies
      concluded with a cesarean section and with the development of transvaginal
      ultrasonography, the frequency of cesarean scar pregnancy diagnoses has increased
      as well. The aim of the study is to evaluate various diagnostic methods
      (ultrasonography in particular) and analyze effective treatment methods for
      cesarean scar pregnancy. An ultrasound scan, Doppler examination and magnetic
      resonance imaging are all useful in early detection of asymptomatic cesarean scar
      pregnancy, thus enabling effective treatment and preservation of fertility.
      Dilatation and curettage is not recommended as it carries significant risk of
      bleeding and very high risk of hysterectomy and fertility loss. Systemic
      methotrexate treatment should not be applied on the routine basis due to its low
      efficacy, high risk of fertility loss and adverse effects. Local methotrexate
      therapy (under ultrasound or hysteroscopy guidance) should be considered a
      perfect management method as it offers fertility preservation in asymptomatic
      pregnant patients without concomitant hemodynamic disorders. Synchronous usage of
      several treatment methods is an effective way to manage cesarean scar pregnancy.
      The combination of local methotrexate with simultaneous aspiration of gestational
      tissues under ultrasound or hysteroscopy guidance seems optimal. Subsequently,
      the remaining gestational tissues can be removed hysteroscopically in combination
      with vascular coagulation at the implantation site. In more advanced cases, local
      methotrexate treatment should be considered followed by laparoscopic or
      laparotomic wedge resection with subsequent surgical correction of the cesarean
      section scar.

PMID- 29844943
TI  - Bacterial meningitis in neonates and infants - the sonographic picture.
AB  - Bacterial meningitis is a major diagnostic and therapeutic problem among children
      and neonates, with severe, rapidly progressing course and potentially life
      threatening complications. Early antibacterial treatment is essential for the
      patient's favorable prognosis. Cerebral imaging plays an important role in the
      diagnostic process alongside physical examination and laboratory tests. Magnetic
      resonance imaging is the gold standard for diagnosing bacterial meningitis.
      Because of limited availability of magnetic resonance imaging, cranial ultrasound
      is the first imaging procedure to be performed (if the anterior fontanelle is
      preserved providing an adequate acoustic window). The safety and reliability of
      ultrasound examination, possibility to perform the examination at bedside without
      the need for sedation make cranial ultrasound a useful tool both for preliminary
      diagnostic investigation and for the monitoring of both treatment and long-term
      complications. Sonographic findings in patients with bacterial meningitis and
      possible complications are diverse. Changes can be seen on the surface of the
      brain, in the extra-axial space, in the ventricular system and in brain tissue.
      In some cases they can also be visible in the lumbosacral segment of the spinal
      cord. This paper presents ultrasound characteristics of lesions associated with
      bacterial meningitis in neonates and infants, based on the authors' own material
      and data from the available literature.

PMID- 29844944
TI  - Anomalous origin of the right coronary artery from the main pulmonary artery
      treated surgically in a 6-week-old infant. A case report and review of the
      literature.
AB  - Background: In the present paper, the authors describe a case of a rare
      congenital defect - anomalous origin of the right coronary artery from the main
      pulmonary artery diagnosed in a 5-week-old infant who was deemed eligible for
      surgical treatment based solely on echocardiography. Such anatomical
      abnormalities of the coronary arteries are subtle and thus extremely difficult to
      visualize, especially in patients in whom permanent extensive damage of the
      cardiac muscle has not yet occurred. For this reason, the diagnosis is usually
      established when the disease is highly advanced, oftentimes only postmortem. In
      this paper, the authors present early echocardiographic evaluation, successful
      surgical treatment and post-operative echocardiographic examination. Case
      presentation: Fetal echocardiographic examinations demonstrated single vascular
      anomalies. The suspicion was verified after birth. Other congenital defects,
      including genetic defects, were also investigated. In the 5th week of life,
      cardiac ECHO showed abnormal origin of the right coronary artery from the trunk
      of the pulmonary artery. The child was deemed eligible for surgical treatment of
      the defect. The surgical translocation of the ostium of the right coronary artery
      to the aorta was done with success, and the child was discharged on the 14th day
      of hospitalization. Conclusion: The present case report demonstrates that careful
      examination of the child with precise echocardiographic examination makes it
      possible to establish an early diagnosis of this rare defect. This discrete
      defect can be treated early, before the symptoms, often connected with
      irreversible changes in the myocardium, appear.

PMID- 29844946
TI  - Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy.
AB  - Dysregulated Wnt signaling is associated with the pathogenesis of cancers,
      fibrosis, and vascular diseases. Inhibition of Wnt signaling has shown efficacy
      in various pre-clinical models of these disorders. One of the key challenges in
      developing targeted anti-cancer drugs is to balance efficacy with on-target
      toxicity. Given the crucial role Wnts play in the differentiation of osteoblasts
      and osteoclasts, acute inhibition of Wnt signaling is likely to affect bone
      homeostasis. In this study, we evaluated the skeletal effect of small molecule
      inhibitor of an o-acyl transferase porcupine (PORCN) that prevents Wnt signaling
      by blocking the secretion of all Wnts. Micro-computed tomography and
      histomorphometric evaluation revealed that the bones of mice treated with two
      structurally distinct PORCN inhibitors LGK974 and ETC-1922159 (ETC-159) had loss
      of-bone volume and density within 4 weeks of exposure. This decreased bone mass
      was associated with a significant increase in adipocytes within the bone marrow.
      Notably, simultaneous administration of a clinically approved anti-resorptive,
      alendronate, a member of the bisphosphonate family, mitigated loss-of-bone mass
      seen upon ETC-159 treatment by regulating activity of osteoclasts and blocking
      accumulation of bone marrow adipocytes. Our results support the addition of bone
      protective agents when treating patients with PORCN inhibitors. Mitigation of
      bone toxicity can extend the therapeutic utility of Wnt pathway inhibitors.

PMID- 29844945
TI  - Paracrine and endocrine actions of bone-the functions of secretory proteins from
      osteoblasts, osteocytes, and osteoclasts.
AB  - The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted
      from bone cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation
      on osteoblastogenesis, osteclastogenesis, and angiogenesis in a paracrine manner.
      Osteoblasts secrete a range of different molecules including RANKL/OPG, M-CSF,
      SEMA3A, WNT5A, and WNT16 that regulate osteoclastogenesis. Osteoblasts also
      produce VEGFA that stimulates osteoblastogenesis and angiogenesis. Osteocytes
      produce sclerostin (SOST) that inhibits osteoblast differentiation and promotes
      osteoclast differentiation. Osteoclasts secrete factors including BMP6, CTHRC1,
      EFNB2, S1P, WNT10B, SEMA4D, and CT-1 that act on osteoblasts and osteocytes, and
      thereby influenceaA osteogenesis. Osteoclast precursors produce the angiogenic
      factor PDGF-BB to promote the formation of Type H vessels, which then stimulate
      osteoblastogenesis. Besides, the evidences over the past decades show that at
      least three hormones or "osteokines" from bone cells have endocrine functions.
      FGF23 is produced by osteoblasts and osteocytes and can regulate phosphate
      metabolism. Osteocalcin (OCN) secreted by osteoblasts regulates systemic glucose
      and energy metabolism, reproduction, and cognition. Lipocalin-2 (LCN2) is
      secreted by osteoblasts and can influence energy metabolism by suppressing
      appetite in the brain. We review the recent progresses in the paracrine and
      endocrine functions of the secretory proteins of osteoblasts, osteocytes, and
      osteoclasts, revealing connections of the skeleton with other tissues and
      providing added insights into the pathogenesis of degenerative diseases affecting
      multiple organs and the drug discovery process.

PMID- 29844947
TI  - Surgical Technical Evidence Review of Hip Fracture Surgery Conducted for the AHRQ
      Safety Program for Improving Surgical Care and Recovery.
AB  - Background: Enhanced recovery pathways (ERPs) have been shown to improve patient
      outcomes in a variety of contexts. This review summarizes the evidence and
      defines a protocol for perioperative care of patients with hip fracture and was
      conducted for the Agency for Healthcare Research and Quality safety program for
      improving surgical care and recovery. Study Design: Perioperative care was
      divided into components or "bins." For each bin, a semisystematic review of the
      literature was conducted using MEDLINE with priority given to systematic reviews,
      meta-analyses, and randomized controlled trials. Observational studies were
      included when higher levels of evidence were not available. Existing guidelines
      for perioperative care were also incorporated. For convenience, the components of
      care that are under the auspices of anesthesia providers will be reported
      separately. Recommendations for an evidence-based protocol were synthesized based
      on review of this evidence. Results: Eleven bins were identified. Preoperative
      risk factor bins included nutrition, diabetes mellitus, tobacco use, and anemia.
      Perioperative management bins included thromboprophylaxis, timing of surgery,
      fluid management, drain placement, early mobilization, early alimentation, and
      discharge criteria/planning. Conclusions: This review provides the evidence basis
      for an ERP for perioperative care of patients with hip fracture.

PMID- 29844948
TI  - Knowledge and Acceptance of Human Papillomavirus Vaccine for Cervical Cancer
      Prevention Among Urban Professional Women in Bangladesh: A Mixed Method Study.
AB  - Prophylactic human papillomavirus (HPV) vaccination is the most effective
      preventive method against invasive cervical cancer, the second leading cause of
      cancer-related deaths among women in Bangladesh. Evidence on women's knowledge
      and perception about cervical cancer and HPV vaccination are needed for effective
      implementation of national cervical cancer prevention programs. The objective of
      this study was to assess the knowledge, attitude, and acceptance of cervical
      cancer, HPV, and HPV vaccination among urban professional women in Bangladesh. We
      recruited 160 female professionals employed at selected private banks in
      Bangladesh. Participants were selected using nonprobability-based convenience
      sampling for interviews through a self-administered questionnaire. Later, in
      depth interviews were conducted with nine of these women. Quantitative data were
      analyzed utilizing descriptive statistics, whereas qualitative data were analyzed
      using a thematic approach. Ninety-eight percent of participants reported that
      they had previously heard of cervical cancer, however, only half (51%) reported
      to have heard of HPV as a cause of the disease. Less than 1% of the 160
      participants had previously undergone a pap smear, and only 2% were vaccinated
      with at least one dose of HPV vaccination. Although knowledge was low, intention
      for acceptance of vaccination was moderate for women and high for their children.
      Although the majority of women had heard of cervical cancer, few women had in
      depth knowledge of HPV and the etiology of invasive disease. This study draws
      attention to the urgent need of educational interventions on cervical cancer and
      its prevention to improve uptake of available HPV vaccination in Bangladesh.

PMID- 29844949
TI  - Potentially inappropriate use of benzodiazepines and z-drugs in the older
      population-analysis of associations between long-term use and patient-related
      factors.
AB  - Introduction: The long-term use of benzodiazepines (BZD) and z-drugs in older
      populations is associated with a variety of sociodemographic and health-related
      factors. Recent studies reported that long-term BZD and z-drugs use is associated
      with increased age, female sex, and severe negative psychological (e.g.,
      depression) and somatic (e.g., chronic disease) factors. The current study
      explores the sociodemographic and health-related factors associated with long
      term BZD and z-drugs use in the elderly. Methods: We conducted a cross-sectional
      survey among randomly selected patients of one health insurance plan ("AOK North
      West") with BZD and z-drugs prescriptions in the past 12 months. The sample was
      stratified by appropriate German prescription guidelines (yes vs. no) and age (50
      65 vs. >65 years). To examine the association of selected sociodemographic and
      psychological variables (e.g., sex, employment status, quality of life,
      depression) with long-term use, a binary logistic regression analysis was
      conducted. Results: In total, data from 340 patients were analyzed. The mean age
      was 72.1 (SD = 14.5) years, and the most commonly used substances were zopiclon
      (38.1%), oxazepam (18.1%), and lorazepam (13.8%). The mean defined daily dose
      (DDD) was 0.73 (SD = 0.47). Insomnia was the main reason for prescribing BZD and
      z-drugs. The long-term use of BZD and z-drugs was significantly associated with
      unemployment (OR = 2.9, 95% CI [1.2-7.1]) and generally problematic medication
      use (OR = 0.5, 95% CI [0.2-1.0]). Discussion: Unemployment status and problematic
      medication use had a significant association with the patient-reported, long-term
      use of BZD and z-drugs. Divergent prescription patterns might suggest problematic
      patterns of BZD and z-drugs use. The causal connection between the identified
      factors and problematic BZD and z-drugs prescription is not discussed in this
      paper. Nevertheless, employment status and possible evidence of general
      problematic drug use may be a warning signal to the prescribers of BZD and z
      drugs.

PMID- 29844950
TI  - Living upside down: patterns of red coral settlement in a cave.
AB  - Background: Larval settlement and intra-specific interactions during the
      recruitment phase are crucial in determining the distribution and density of
      sessile marine populations. Marine caves are confined and stable habitats. As
      such, they provide a natural laboratory to study the settlement and recruitment
      processes in sessile invertebrates, including the valuable Mediterranean red
      coral Corallium rubrum. In the present study, the spatial and temporal
      variability of red coral settlers in an underwater cave was investigated by
      demographic and genetic approaches. Methods: Sixteen PVC tiles were positioned on
      the walls and ceiling of the Colombara Cave, Ligurian Sea, and recovered after
      twenty months. A total of 372 individuals of red coral belonging to two different
      reproductive events were recorded. Basal diameter, height, and number of polyps
      were measured, and seven microsatellites loci were used to evaluate the genetic
      relationships among individuals and the genetic structure. Results: Significant
      differences in the colonization rate were observed both between the two temporal
      cohorts and between ceiling and walls. No genetic structuring was observed
      between cohorts. Overall, high levels of relatedness among individuals were
      found. Conclusion: The results show that C. rubrumindividuals on tiles are highly
      related at very small spatial scales, suggesting that nearby recruits are likely
      to be sibs. Self-recruitment and the synchronous settlement of clouds of larvae
      could be possible explanations for the observed pattern.

PMID- 29844951
TI  - Giant worms chez moi! Hammerhead flatworms (Platyhelminthes, Geoplanidae,
      Bipalium spp., Diversibipalium spp.) in metropolitan France and overseas French
      territories.
AB  - Background: Species of the genera Bipalium and Diversibipalium, or bipaliines,
      are giants among land planarians (family Geoplanidae), reaching length of 1 m;
      they are also easily distinguished from other land flatworms by the
      characteristic hammer shape of their head. Bipaliines, which have their origin in
      warm parts of Asia, are invasive species, now widespread worldwide. However, the
      scientific literature is very scarce about the widespread repartition of these
      species, and their invasion in European countries has not been studied. Methods:
      In this paper, on the basis of a four year survey based on citizen science, which
      yielded observations from 1999 to 2017 and a total of 111 records, we provide
      information about the five species present in Metropolitan France and French
      overseas territories. We also investigated the molecular variability of
      cytochrome-oxidase 1 (COI) sequences of specimens. Results: Three species are
      reported from Metropolitan France: Bipalium kewense, Diversibipalium
      multilineatum, and an unnamed Diversibipalium 'black' species. We also report the
      presence of B. kewense from overseas territories, such as French Polynesia
      (Oceania), French Guiana (South America), the Caribbean French islands of
      Martinique, Guadeloupe, Saint Martin and Saint Barthelemy, and Montserrat
      (Central America), and La Reunion island (off South-East Africa). For B. vagum,
      observations include French Guiana, Guadeloupe, Martinique, Saint Barthelemy,
      Saint Martin, Montserrat, La Reunion, and Florida (USA). A probable new species,
      Diversibipalium sp. 'blue,' is reported from Mayotte Island (off South-East
      Africa). B. kewense, B. vagum and D. multilineatum each showed 0% variability in
      their COI sequences, whatever their origin, suggesting that the specimens are
      clonal, and that sexual reproduction is probably absent. COI barcoding was
      efficient in identifying species, with differences over 10% between species; this
      suggests that barcoding can be used in the future for identifying these invasive
      species. In Metropolitan south-west France, a small area located in the
      Department of Pyrenees-Atlantiques was found to be a hot-spot of bipaliine
      biodiversity and abundance for more than 20 years, probably because of the local
      mild weather. Discussion: The present findings strongly suggest that the species
      present in Metropolitan France and overseas territories should be considered
      invasive alien species. Our numerous records in the open in Metropolitan France
      raise questions: as scientists, we were amazed that these long and brightly
      coloured worms could escape the attention of scientists and authorities in a
      European developed country for such a long time; improved awareness about land
      planarians is certainly necessary.

PMID- 29844952
TI  - Planning protected areas network that are relevant today and under future climate
      change is possible: the case of Atlantic Forest endemic birds.
AB  - Background: A key strategy in biodiversity conservation is the establishment of
      protected areas. In the future, however, the redistribution of species in
      response to ongoing climate change is likely to affect species'
      representativeness in those areas. Here we quantify the effectiveness of planning
      protected areas network to represent 151 birds endemic to the Brazilian Atlantic
      Forest hotspot, under current and future climate change conditions for 2050.
      Methods: We combined environmental niche modeling and systematic conservation
      planning using both a county and a regional level planning strategy. We
      recognized the conflict between biodiversity conservation and economic
      development, including socio-economic targets (as opposed to biological only) and
      using planning units that are meaningful for policy-makers. Results: We estimated
      an average contraction of 29,500 km2 in environmentally suitable areas for birds,
      representing 52% of currently suitable areas. Still, the most cost-effective
      solution represented almost all target species, requiring only ca. 10% of the
      Atlantic Forest counties to achieve that representativeness, independent of
      strategy. More than 50% of these counties were selected both in the current and
      future planned networks, representing >83% of the species. Discussion: Our
      results indicate that: (i) planning protected areas network currently can be
      useful to represent species under climate change; (ii) the overlapped planning
      units in the best solution for both current and future conditions can be
      considered as "no regret" areas; (iii) priority counties are spread throughout
      the biome, providing specific guidance wherever the possibility of creating
      protected area arises; and (iv) decisions can occur at different administrative
      spheres (Federal, State or County) as we found quite similar numerical solutions
      using either county or regional level strategies.

PMID- 29844953
TI  - The role of gut microbiota in the regulation of standard metabolic rate in female
      Periplaneta americana.
AB  - Insect gut microbiota contribute significantly to host nutritional ecology.
      Disrupting insect gut microbial assemblages impacts nutrient provisioning
      functions, and can potentially affect host standard metabolic rate (SMR), a
      measure of host energy balance. In this study, we evaluated the effect of
      disrupting gut microbial assemblages on the SMR of female Periplaneta americana
      cockroaches fed dog food (DF, high protein/carbohydrate (p/c) ratio), and
      cellulose-amended dog food (CADF, 30% dog food, 70% cellulose, low p/c ratio)
      diets, supplemented with none, low, or high antibiotic doses. Bacterial loads
      decreased significantly between diet types (P = 0.04) and across antibiotic doses
      (P = 0.04). There was a significant diet type x antibiotic dose interaction on
      SMR of females on both diets (P = 0.05) by the end of the seven-day experimental
      period. In CADF-fed females, SMR decreased linearly with decreasing bacterial
      load. However, SMR of DF-fed females on the low dose was significantly higher
      than those in the control and high dose groups. This is interpreted as a diet
      dependent response by low dose DF-fed females to the loss of nutritional services
      provided by gut bacteria. Severe reductions in bacterial load at high doses
      reduced SMR of females on both diet types. This study provides insights into the
      potential role of gut bacteria as modulators of host energy expenditure under
      varying dietary conditions.

PMID- 29844954
TI  - The complete chloroplast genome of Colobanthus apetalus (Labill.) Druce: genome
      organization and comparison with related species.
AB  - Colobanthus apetalus is a member of the genus Colobanthus, one of the 86 genera
      of the large family Caryophyllaceae which groups annual and perennial herbs
      (rarely shrubs) that are widely distributed around the globe, mainly in the
      Holarctic. The genus Colobanthus consists of 25 species, including Colobanthus
      quitensis, an extremophile plant native to the maritime Antarctic. Complete
      chloroplast (cp) genomes are useful for phylogenetic studies and species
      identification. In this study, next-generation sequencing (NGS) was used to
      identify the cp genome of C. apetalus. The complete cp genome of C. apetalus has
      the length of 151,228 bp, 36.65% GC content, and a quadripartite structure with a
      large single copy (LSC) of 83,380 bp and a small single copy (SSC) of 17,206 bp
      separated by inverted repeats (IRs) of 25,321 bp. The cp genome contains 131
      genes, including 112 unique genes and 19 genes which are duplicated in the IRs.
      The group of 112 unique genes features 73 protein-coding genes, 30 tRNA genes,
      four rRNA genes and five conserved chloroplast open reading frames (ORFs). A
      total of 12 forward repeats, 10 palindromic repeats, five reverse repeats and
      three complementary repeats were detected. In addition, a simple sequence repeat
      (SSR) analysis revealed 41 (mono-, di-, tri-, tetra-, penta- and hexanucleotide)
      SSRs, most of which were AT-rich. A detailed comparison of C. apetalus and C.
      quitensis cp genomes revealed identical gene content and order. A phylogenetic
      tree was built based on the sequences of 76 protein-coding genes that are shared
      by the eleven sequenced representatives of Caryophyllaceae and C. apetalus, and
      it revealed that C. apetalus and C. quitensis form a clade that is closely
      related to Silene species and Agrostemma githago. Moreover, the genus Silene
      appeared as a polymorphic taxon. The results of this study expand our knowledge
      about the evolution and molecular biology of Caryophyllaceae.

PMID- 29844955
TI  - Effects of long-term fertilisation on aggregates and dynamics of soil organic
      carbon in a semi-arid agro-ecosystem in China.
AB  - Background: Long-term fertilisation has a large influence on soil physical and
      chemical properties in agro-ecosystems. The effects on the distribution of
      aggregates, however, are not fully understood. We determined the dynamic change
      of the distribution of aggregates and soil organic carbon (SOC) content over time
      in a long-term field experiment established in 1998 on the Loess Plateau of China
      and illustrated the relationship between them. Methods: We determined SOC content
      and the distribution of aggregates in nine fertiliser treatments: manure (M);
      nitrogen (N); phosphorus (P); M and N; M, N, and P; M and P; N and P; bare land;
      and an unfertilised control. These parameters were then used for a path analysis
      and to analyse the fractal dimension (Dv). Results: The organic fertiliser
      increased SOC content. The proportions of 0.1-0.25 mm microaggregates and 0.25
      0.5 mm macroaggregates were higher and the proportion of the 0.01-0.05 mm size
      class of the silt + clay fraction was lower in the treatments receiving organic
      fertiliser (M, MN, MNP, and MP) than that in the control, indicating that the
      addition of organic fertiliser promoted aggregation. The distribution of
      aggregates characterised by their fractal dimension (Dv ), however, did not
      differ among the treatments. Discussion: Dv was strongly correlated with the
      proportion of the <0.002 mm size class of the silt + clay fraction that did not
      differ significantly among the treatments. The change in the distribution of
      aggregates was strongly correlated with SOC content, which could produce organic
      polymer binding agents to increase the proportion of larger particles. Long-term
      application of organic fertiliser is thus necessary for the improvement and
      maintenance of soil quality in semi-arid agricultural land when residues are
      removed.

PMID- 29844956
TI  - Intolerance of uncertainty and conditioned place preference in opioid addiction.
AB  - Several personality factors have been implicated in vulnerability to addiction by
      impacting learning and decision making. One such factor is intolerance of
      uncertainty (IU), the tendency to perceive uncertain situations negatively and
      avoid them. Conditioned place preference (CPP), which compares preference for
      contexts paired with reward, has been used to examine the motivation for both
      drug and non-drug rewards. However, preference for locations associated with non
      drug reward, as well as the potential influence of IU, has not been thoroughly
      studied in individuals with addiction. In the current study, we examined CPP
      using a computer-based task in a sample of addicted individuals undergoing opioid
      maintenance treatment and never-addicted controls. Patients were confirmed to
      have higher IU than controls. In the CPP task, the two groups did not differ in
      overall time spent in the previously-rewarded context. However, controls were
      more likely than patients to immediately return to this context. Contrary to our
      predictions, IU was not a significant predictor of preference for the previously
      rewarded context, although higher IU in controls was associated with a higher
      number of rewards obtained in the task. No such relationship was found in
      patients.

PMID- 29844957
TI  - Multilocus phylogeny of the parasitic wasps in the tribe Euphorini (Hymenoptera:
      Braconidae) with revised generic classifications.
AB  - Background: Parasitic wasps in the family Braconidae are important regulators of
      insect pests, particularly in forest and agroecosystems. Within Braconidae, wasps
      in the tribe Euphorini (Euphorinae) attack economically damaging plant bugs
      (Miridae) that are major pests of field and vegetable crops. However, the
      evolutionary relationships of this tribe have been historically problematic. Most
      generic concepts have been based on ambiguous morphological characters which
      often leads to misidentification, complicating their use in biological control.
      Methods: Using a combination of three genes (COI, 28S, and CAD) and 80 taxa
      collected worldwide, we conducted Bayesian inference using MrBayes, and maximum
      likelihood analyses using RAxML and IQ-Tree on individual gene trees as well as
      the concatenated dataset. Results: The monophyly of the tribe Euphorini and the
      two genera Peristenus and Leiophron were confirmed using maximum likelihood and
      Bayesian inference. The subgeneric classifications of Leiophron sensu lato were
      not supported, and the monotypic genus Mama was also not supported. Discussion:
      Euphoriella, Euphoriana, Euphorus, and Mamasyn. n, have been synonymized under
      Leiophron. Mama mariaesyn. n was placed as a junior synonym of Leiophron
      reclinator. The generic concepts of Peristenus and Leiophron were refined to
      reflect the updated phylogeny. Further we discuss the need for revising Euphorini
      given the number of undescribed species within the tribe.

PMID- 29844958
TI  - Large mammal burrows in late Miocene calcic paleosols from central Argentina:
      paleoenvironment, taphonomy and producers.
AB  - Large cylindrical sediment-filled structures interpreted as mammal burrows occur
      within the loess-paleosol sequence of the late Miocene Cerro Azul Formation of
      central Argentina. A total of 115 burrow fills from three localities were
      measured. They are typically shallowly dipping, subcylindrical, unbranched
      structures with rounded ends and lacking enlargements. The horizontal diameter of
      the burrows range between 0.15 and 1.50 m, with most of the burrows in the
      interval of 0.39 to 0.98 m. Geometric morphometric analysis of transverse cross
      sections support their distinct subcircular and elliptical (horizontally
      flattened) shapes. Burrow fills are typically laminated in the lower part and
      massive in the upper part. The laminated intervals reflect pulses of flowing
      water entering the abandoned burrow during moderate rains, whereas massive
      intervals reflect mass flow input of dense sediment-water mixtures during heavy
      rains that produced sheet floods. Approximately 1% of the burrows contained
      fragmentary, disarticulated and weathered mammal bones that were introduced in
      the open burrow by currents along with other sedimentary particles. Analysis of
      the tetrapod burrow fossil record suggests that Miocene burrows, including those
      studied herein, reflect a remarkable increase in the average size of the
      fossorial fauna. We conclude that large late Miocene mammals dug burrows
      essentially as a shelter against environmental extremes and to escape predation.
      The simple architecture of the burrows suggests that the producers essentially
      foraged aboveground. Several mammal groups acquired fossorial habits in response
      to cold and seasonally dry climatic conditions that prevailed during the late
      Miocene in southern South America. The considerable range of horizontal diameters
      of the studied burrows can be attributed to a variety of producers, including
      dasypodids, the notoungulate Paedotherium minor, Glyptodontidae and Proscelidodon
      sp.

PMID- 29844959
TI  - Evaluation of the glycemic effect of Ceratonia siliqua pods (Carob) on a
      streptozotocin-nicotinamide induced diabetic rat model.
AB  - Background: Ceratonia siliqua pods (carob) have been nominated to control the
      high blood glucose of diabetics. In Yemen, however, its antihyperglycemic
      activity has not been yet assessed. Thus, this study evaluated the in vitro
      inhibitory effect of the methanolic extract of carob pods against alpha-amylase
      and alpha-glucosidase and the in vivo glycemic effect of such extract in
      streptozotocin-nicotinamide induced diabetic rats. Methods: 2,2-diphenyl-1
      picrylhydrazyl (DPPH) and Ferric reducing antioxidant power assay (FRAP) were
      applied to evaluate the antioxidant activity of carob. In vitro cytotoxicity of
      carob was conducted on human hepatocytes (WRL68) and rat pancreatic beta-cells
      (RIN-5F). Acute oral toxicity of carob was conducted on a total of 18 male and 18
      female Sprague-Dawley (SD) rats, which were subdivided into three groups (n = 6),
      namely: high and low dose carob-treated (CS5000 and CS2000, respectively) as well
      as the normal control (NC) receiving a single oral dose of 5,000 mg kg-1 carob,
      2,000 mg kg-1 carob and 5 mL kg-1 distilled water for 14 days, respectively.
      Alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, total
      bilirubin, creatinine and urea were assessed. Livers and kidneys were harvested
      for histopathology. In vitro inhibitory effect against alpha-amylase and alpha
      glucosidase was evaluated. In vivo glycemic activity was conducted on 24 male SD
      rats which were previously intraperitoneally injected with 55 mg kg-1
      streptozotocin (STZ) followed by 210 mg kg-1nicotinamide to induce type 2
      diabetes mellitus. An extra non-injected group (n = 6) was added as a normal
      control (NC). The injected-rats were divided into four groups (n = 6), namely:
      diabetic control (D0), 5 mg kg-1glibenclamide-treated diabetic (GD), 500 mg kg-1
      carob-treated diabetic (CS500) and 1,000 mg kg-1 carob-treated diabetic (CS1000).
      All groups received a single oral daily dose of their treatment for 4 weeks. Body
      weight, fasting blood glucose (FBG), oral glucose tolerance test, biochemistry,
      insulin and hemostatic model assessment were assessed. Pancreases was harvested
      for histopathology. Results: Carob demonstrated a FRAP value of 3191.67 +/- 54.34
      umoL Fe++ and IC50 of DPPH of 11.23 +/- 0.47 ug mL-1. In vitro, carob was non
      toxic on hepatocytes and pancreatic beta-cells. In acute oral toxicity, liver and
      kidney functions and their histological sections showed no abnormalities. Carob
      exerted an in vitro inhibitory effect against alpha-amylase and alpha-glucosidase
      with IC50 of 92.99 +/- 0.22 and 97.13 +/- 4.11 ug mL-1, respectively. In diabetic
      induced rats, FBG of CS1000 was significantly less than diabetic control.
      Histological pancreatic sections of CS1000 showed less destruction of beta-cells
      than CS500 and diabetic control. Conclusion: Carob pod did not cause acute
      systemic toxicity and showed in vitro antioxidant effects. On the other hand,
      inhibiting alpha-amylase and alpha-glucosidase was evident. Interestingly, a high
      dose of carob exhibits an in vivo antihyperglycemic activity and warrants further
      in-depth study to identify the potential carob extract composition.

PMID- 29844960
TI  - Understanding mitochondrial myopathies: a review.
AB  - Mitochondria are small, energy-producing structures vital to the energy needs of
      the body. Genetic mutations cause mitochondria to fail to produce the energy
      needed by cells and organs which can cause severe disease and death. These
      genetic mutations are likely to be in the mitochondrial DNA (mtDNA), or possibly
      in the nuclear DNA (nDNA). The goal of this review is to assess the current
      understanding of mitochondrial diseases. This review focuses on the pathology,
      causes, risk factors, symptoms, prevalence data, symptomatic treatments, and new
      research aimed at possible preventions and/or treatments of mitochondrial
      diseases. Mitochondrial myopathies are mitochondrial diseases that cause
      prominent muscular symptoms such as muscle weakness and usually present with a
      multitude of symptoms and can affect virtually all organ systems. There is no
      cure for these diseases as of today. Treatment is generally supportive and
      emphasizes symptom management. Mitochondrial diseases occur infrequently and
      hence research funding levels tend to be low in comparison with more common
      diseases. On the positive side, quite a few genetic defects responsible for
      mitochondrial diseases have been identified, which are in turn being used to
      investigate potential treatments. Speech therapy, physical therapy, and
      respiratory therapy have been used in mitochondrial diseases with variable
      results. These therapies are not curative and at best help with maintaining a
      patient's current abilities to move and function.

PMID- 29844961
TI  - A brief introduction to mixed effects modelling and multi-model inference in
      ecology.
AB  - The use of linear mixed effects models (LMMs) is increasingly common in the
      analysis of biological data. Whilst LMMs offer a flexible approach to modelling a
      broad range of data types, ecological data are often complex and require complex
      model structures, and the fitting and interpretation of such models is not always
      straightforward. The ability to achieve robust biological inference requires that
      practitioners know how and when to apply these tools. Here, we provide a general
      overview of current methods for the application of LMMs to biological data, and
      highlight the typical pitfalls that can be encountered in the statistical
      modelling process. We tackle several issues regarding methods of model selection,
      with particular reference to the use of information theory and multi-model
      inference in ecology. We offer practical solutions and direct the reader to key
      references that provide further technical detail for those seeking a deeper
      understanding. This overview should serve as a widely accessible code of best
      practice for applying LMMs to complex biological problems and model structures,
      and in doing so improve the robustness of conclusions drawn from studies
      investigating ecological and evolutionary questions.

PMID- 29844962
TI  - Water mites (Acari, Hydrachnidia) of riparian springs in a small lowland river
      valley: what are the key factors for species distribution?
AB  - This paper examines the impact of disturbance factors-flooding and intermittency
      on the distribution of water mites in the riparian springs situated in the valley
      of a small lowland river, the Krapiel. The landscape factors and physicochemical
      parameters of the water were analysed in order to gain an understanding of the
      pattern of water mite assemblages in the riparian springs. Three limnological
      types of springs were examined (helocrenes, limnocrenes and rheocrenes) along the
      whole course of the river and a total of 35 water mite species were found. Our
      study shows that flooding influences spring assemblages, causing a decrease in
      crenobiontic water mites in flooded springs. The impact of intermittency resulted
      in a high percentage of species typical of temporary water bodies. Surprisingly,
      the study revealed the positive impact of the anthropogenic transformation of the
      river valley: preventing the riparian springs from flooding enhances the
      diversity of crenobiontic species in non-flooded springs. In the conclusion, our
      study revealed that further conservation strategies for the protection of the
      riparian springs along large rivers would take into account ongoing climatic
      changes and possible the positive impact of the anthropogenic transformation of
      river valleys.

PMID- 29844963
TI  - Influence of aprepitant on the pharmacodynamics and pharmacokinetics of
      gliclazide in rats and rabbits.
AB  - Background: Concomitant drug administration is a general phenomenon in patients
      with chronic diseases such as diabetes mellitus. Among the currently available
      oral antidiabetic drugs, gliclazide is a commonly prescribed drug considering its
      multiple benefits in diabetic patients. Aprepitant is a commonly prescribed
      antiemetic drug which is mainly metabolized by CYP3A4, reported to have modest
      inductive and inhibitory effects on CYP2C9 and CYP3A4, respectively. Since
      gliclazide is metabolized by CYP2C9 (major) and CYP3A4 (minor), it is very
      difficult to predict the influence of aprepitant and its metabolic interaction
      with gliclazide. Considering the complexity associated with the combination of
      aprepitant and gliclazide, this study was designed to evaluate the influence of
      aprepitant on the pharmacodynamics (PD) and pharmacokinetics (PK) of gliclazide
      in animal models. Methods: The PD interaction studies were conducted in both
      rodent (normal and alloxan-induced diabetic rats) and non-rodent (rabbits) animal
      models (n = 6) while the PK interaction study was conducted in normal rabbits (n
      = 6). An extrapolated human therapeutic oral dose of gliclazide, aprepitant and
      their combination were administered to rats and rabbits with 7 days washout
      between each treatment. For the multiple-dose interaction study, the same groups
      were administered with an interacting drug (aprepitant) for 7 days and then the
      combination of aprepitant and gliclazide on the 8th day. From the collected
      animal blood samples, blood glucose (by Glucose-Oxidase/Peroxidase method),
      insulin (by ELISA method) and gliclazide concentration levels (by HPLC method)
      were determined. Non-compartmental PK analysis was conducted by Phoenix WinNonlin
      software to determine the PK parameters of gliclazide. Statistical analysis was
      performed by student's paired t-test. Results: The pharmacodynamic activity
      (blood glucose reduction and insulin levels) of gliclazide was significantly (p <
      0.05) influenced by aprepitant in normal and diabetic condition without any
      convulsions in animals. There was a significant (p < 0.05) increase in
      concentration levels and Area Under the Curve of gliclazide while significant (p
      < 0.05) decrease in clearance levels of gliclazide in rabbits. The PK interaction
      with gliclazide is relatively more with the multiple dose treatment of aprepitant
      over single dose treatment. Conclusion: In combination, aprepitant significantly
      influenced the pharmacodynamic activity of gliclazide in animal models.
      Considering this, care should be taken when this combination is prescribed for
      the clinical benefit in diabetic patients.

PMID- 29844964
TI  - The influence of temperature and photoperiod on the timing of brood onset in
      hibernating honey bee colonies.
AB  - In order to save resources, honey bee (Apis mellifera) colonies in the temperate
      zones stop brood rearing during winter. Brood rearing is resumed in late winter
      to build up a sufficient worker force that allows to exploit floral resources in
      upcoming spring. The timing of brood onset in hibernating colonies is crucial and
      a premature brood onset could lead to an early depletion of energy reservoirs.
      However, the mechanisms underlying the timing of brood onset and potential risks
      of mistiming in the course of ongoing climate change are not well understood. To
      assess the relative importance of ambient temperature and photoperiod as
      potential regulating factors for brood rearing activity in hibernating colonies,
      we overwintered 24 honey bee colonies within environmental chambers. The colonies
      were assigned to two different temperature treatments and three different
      photoperiod treatments to disentangle the individual and interacting effects of
      temperature and photoperiod. Tracking in-hive temperature as indicator for brood
      rearing activity revealed that increasing ambient temperature triggered brood
      onset. Under cold conditions, photoperiod alone did not affect brood onset, but
      the light regime altered the impact of higher ambient temperature on brood
      rearing activity. Further the number of brood rearing colonies increased with
      elapsed time which suggests the involvement of an internal clock. We conclude
      that timing of brood onset in late winter is mainly driven by temperature but
      modulated by photoperiod. Climate warming might change the interplay of these
      factors and result in mismatches of brood phenology and environmental conditions.

PMID- 29844965
TI  - Effect of Reactive Black 5 azo dye on soil processes related to C and N cycling.
AB  - Azo dyes are one of the largest classes of synthetic dyes being used in textile
      industries. It has been reported that 15-50% of these dyes find their way into
      wastewater that is often used for irrigation purpose in developing countries. The
      effect of azo dyes contamination on soil nitrogen (N) has been studied
      previously. However, how does the azo dye contamination affect soil carbon (C)
      cycling is unknown. Therefore, we assessed the effect of azo dye contamination
      (Reactive Black 5, 30 mg kg-1 dry soil), bacteria that decolorize this dye and
      dye + bacteria in the presence or absence of maize leaf litter on soil
      respiration, soil inorganic N and microbial biomass. We found that dye
      contamination did not induce any change in soil respiration, soil microbial
      biomass or soil inorganic N availability (P > 0.05). Litter evidently increased
      soil respiration. Our study concludes that the Reactive Black 5 azo dye (applied
      in low amount, i.e., 30 mg kg-1 dry soil) contamination did not modify organic
      matter decomposition, N mineralization and microbial biomass in a silty loam
      soil.

PMID- 29844966
TI  - Finding novel relationships with integrated gene-gene association network
      analysis of Synechocystis sp. PCC 6803 using species-independent text-mining.
AB  - The increasing move towards open access full-text scientific literature enhances
      our ability to utilize advanced text-mining methods to construct information-rich
      networks that no human will be able to grasp simply from 'reading the
      literature'. The utility of text-mining for well-studied species is obvious
      though the utility for less studied species, or those with no prior track-record
      at all, is not clear. Here we present a concept for how advanced text-mining can
      be used to create information-rich networks even for less well studied species
      and apply it to generate an open-access gene-gene association network resource
      for Synechocystis sp. PCC 6803, a representative model organism for cyanobacteria
      and first case-study for the methodology. By merging the text-mining network with
      networks generated from species-specific experimental data, network integration
      was used to enhance the accuracy of predicting novel interactions that are
      biologically relevant. A rule-based algorithm (filter) was constructed in order
      to automate the search for novel candidate genes with a high degree of likely
      association to known target genes by (1) ignoring established relationships from
      the existing literature, as they are already 'known', and (2) demanding multiple
      independent evidences for every novel and potentially relevant relationship.
      Using selected case studies, we demonstrate the utility of the network resource
      and filter to (i) discover novel candidate associations between different genes
      or proteins in the network, and (ii) rapidly evaluate the potential role of any
      one particular gene or protein. The full network is provided as an open-source
      resource.

PMID- 29844967
TI  - Endozoochory by mallard in New Zealand: what seeds are dispersed and how far?
AB  - In Europe and North America waterfowl are major dispersers of aquatic and
      terrestrial plants, but in New Zealand their role has yet to be investigated.
      Mallards were introduced to New Zealand in the late 1800s, and today they are the
      most abundant and widespread waterfowl in the country. To assess seed dispersal,
      we radiomarked 284 female mallards from two study sites during the pre-breeding
      (June-August) and breeding (August-December) periods in 2014-2015, and examined
      movements that occurred within 24, 48 or 72 h when seed dispersal by endozoochory
      is considered likely. During June and July 2015, we collected 29 faecal samples
      from individual female mallards during radiomarking and 24 samples from mallard
      flocks. We recovered 69 intact seeds from the faecal samples and identified 12
      plant taxa. Of the plant seeds identified and dispersed by mallards in this
      study, 40% were members of the Asteraceae family, nine plant species were alien
      to New Zealand, and the indigenous-status of three unidentified taxa could not be
      determined. Two taxa (and 9% of seeds) were germinated following gut passage: an
      unidentified Asteraceae and Solanum nigrum. During the pre-breeding and breeding
      periods, movement of females within 24 h averaged 394 m (SD = 706 m) and 222 m
      (SD = 605 m) respectively, with maximum distances of 3,970 m and 8,028 m. Maxima
      extended to 19,230 m within 48 h. Most plant species recorded are generally
      assumed to be self-dispersed or dispersed by water; mechanisms that provide a
      much lower maximum dispersal distance than mallards. The ability of mallards to
      disperse viable seeds up to 19 km within 48 h suggests they have an important and
      previously overlooked role as vectors for a variety of wetland or grassland plant
      species in New Zealand.

PMID- 29844968
TI  - High correlation between skin color based on CIELAB color space, epidermal
      melanocyte ratio, and melanocyte melanin content.
AB  - Background: To treat skin color disorders, such as vitiligo or burns, melanocytes
      are transplanted for tissue regeneration. However, melanocyte distribution in the
      human body varies with age and location, making it difficult to select the
      optimal donor skin to achieve a desired color match. Determining the correlations
      with the desired skin color measurement based on CIELAB color, epidermal
      melanocyte numbers, and melanin content of individual melanocytes is critical for
      clinical application. Method: Fifteen foreskin samples from Asian young adults
      were analyzed for skin color, melanocyte ratio (melanocyte proportion in the
      epidermis), and melanin concentration. Furthermore, an equation was developed
      based on CIELAB color with melanocyte ratio, melanin concentration, and the
      product of melanocyte ratio and melanin concentration. The equation was validated
      by seeding different ratios of keratinocytes and melanocytes in tissue-engineered
      skin substitutes, and the degree of fitness in expected skin color was confirmed.
      Results: Linear regression analysis revealed a significant strong negative
      correlation (r =  - 0.847, R2 = 0.717) between CIELAB L* value and the product of
      the epidermal melanocyte ratio and cell-based melanin concentration. Furthermore,
      the results showed that an optimal skin color match was achieved by the formula.
      Discussion: We found that L* value was correlated with the value obtained from
      multiplying the epidermal melanocyte ratio (R) and melanin content (M) and that
      this correlation was more significant than either L* vs M or L* vs R. This
      suggests that more accurate prediction of skin color can be achieved by
      considering both R and M. Therefore, precise skin color match in treating
      vitiligo or burn patients would be potentially achievable based on extensive
      collection of skin data from people of Asian descent.

PMID- 29844969
TI  - An improved primer set and amplification protocol with increased specificity and
      sensitivity targeting the Symbiodinium ITS2 region.
AB  - The Internal Transcribed Spacer 2 (ITS2) rRNA gene is a commonly targeted genetic
      marker to assess diversity of Symbiodinium, a dinoflagellate genus of algal
      endosymbionts that is pervasively associated with marine invertebrates, and
      notably reef-building corals. Here we tested three commonly used ITS2 primer
      pairs (SYM_VAR_5.8S2/SYM_VAR_REV, ITSintfor2/ITSReverse, and ITS-DINO/ITS2Rev2)
      with regard to amplification specificity and sensitivity towards Symbiodinium, as
      well as sub-genera taxonomic bias. We tested these primers over a range of sample
      types including three coral species, coral surrounding water, reef surface water,
      and open ocean water to assess their suitability for use in large-scale next
      generation sequencing projects and to develop a standardised PCR protocol. We
      found the SYM_VAR_5.8S2/SYM_VAR_REV primers to perform superior to the other
      tested ITS2 primers. We therefore used this primer pair to develop a standardised
      PCR protocol. To do this, we tested the effect of PCR-to-PCR variation, annealing
      temperature, cycle number, and different polymerase systems on the PCR efficacy.
      The Symbiodinium ITS2 PCR protocol developed here delivers improved specificity
      and sensitivity towards Symbiodinium with apparent minimal sub-genera taxonomic
      bias across all sample types. In particular, the protocol's ability to amplify
      Symbiodinium from a range of environmental sources will facilitate the study of
      Symbiodinium populations across biomes.

PMID- 29844970
TI  - Sample entropy analysis for the estimating depth of anaesthesia through human EEG
      signal at different levels of unconsciousness during surgeries.
AB  - Estimating the depth of anaesthesia (DoA) in operations has always been a
      challenging issue due to the underlying complexity of the brain mechanisms.
      Electroencephalogram (EEG) signals are undoubtedly the most widely used signals
      for measuring DoA. In this paper, a novel EEG-based index is proposed to evaluate
      DoA for 24 patients receiving general anaesthesia with different levels of
      unconsciousness. Sample Entropy (SampEn) algorithm was utilised in order to
      acquire the chaotic features of the signals. After calculating the SampEn from
      the EEG signals, Random Forest was utilised for developing learning regression
      models with Bispectral index (BIS) as the target. Correlation coefficient, mean
      absolute error, and area under the curve (AUC) were used to verify the
      perioperative performance of the proposed method. Validation comparisons with
      typical nonstationary signal analysis methods (i.e., recurrence analysis and
      permutation entropy) and regression methods (i.e., neural network and support
      vector machine) were conducted. To further verify the accuracy and validity of
      the proposed methodology, the data is divided into four unconsciousness-level
      groups on the basis of BIS levels. Subsequently, analysis of variance (ANOVA) was
      applied to the corresponding index (i.e., regression output). Results indicate
      that the correlation coefficient improved to 0.72 +/- 0.09 after filtering and to
      0.90 +/- 0.05 after regression from the initial values of 0.51 +/- 0.17.
      Similarly, the final mean absolute error dramatically declined to 5.22 +/- 2.12.
      In addition, the ultimate AUC increased to 0.98 +/- 0.02, and the ANOVA analysis
      indicates that each of the four groups of different anaesthetic levels
      demonstrated significant difference from the nearest levels. Furthermore, the
      Random Forest output was extensively linear in relation to BIS, thus with better
      DoA prediction accuracy. In conclusion, the proposed method provides a concrete
      basis for monitoring patients' anaesthetic level during surgeries.

PMID- 29844971
TI  - Feeding behavior and trophic interaction of three shark species in the Galapagos
      Marine Reserve.
AB  - There is great concern about the future of sharks in Ecuador because of the lack
      of biological knowledge of most species that inhabit the region. This paper
      analyzes the feeding behavior of the pelagic thresher shark (Alopias pelagicus),
      the blue shark (Prionace glauca) and the silky shark (Carcharhinus falciformis)
      through the use of stable isotopes of carbon and nitrogen (delta13C and
      delta15N), with the aim of determining the degree of interaction between these
      species in the Galapagos Marine Reserve. No interspecific differences were found
      in use of oceanic vs. inshore feeding areas (delta13C: Kruskal-Wallis test, p =
      0.09). The position in the hierarchy of the food web where A. pelagicus feeds
      differed from that of the other species (delta15N: Kruskal-Wallis test, p =
      0.01). There were no significant differences in delta13C and delta15N values
      between males and females of the three species (Student's t-test, p > 0.05),
      which suggests that both sexes have a similar feeding behavior. A specialist
      strategy was observed in P. glauca (trophic niche breadth TNB = 0.69), while the
      other species were found to be generalist (A. pelagicus TNB = 1.50 and C.
      falciformis TNB = 1.09). The estimated trophic level (TL) varied between the
      three species. C. falciformis occupied the highest trophic level (TL = 4.4),
      making it a quaternary predator in the region. The results of this study coincide
      with the identified behavior in these predators in other areas of the tropical
      Pacific (Colombia and Mexico), and suggest a pelagic foraging strategy with
      differential consumption of prey between the three species. These ecological
      aspects can provide timely information when implementing in conservation measures
      for these shark species in the Tropical Pacific and Galapagos Marine Reserve.

PMID- 29844972
TI  - Fingerprinting snakes: paleontological and paleoecological implications of
      zygantral growth rings in Serpentes.
AB  - We introduce a new non-destructive source of skeletochronological data with
      applications to species identification, associating disarticulated remains,
      assessing minimum number of individuals (MNI), and collection management of
      fossil snakes, but with potential implications for all bony vertebrates, extinct
      or extant. Study of a diverse sample of Recent henophidian snakes confirms that
      annual growth cycles (AGCs) visible on the surface of the vertebral zygantrum
      correspond to lines of arrested growth in osteohistological thin sections and
      accordingly reflect chronological age. None of the specimens considered here
      showed signs of remodelling of the zygantrum, suggesting that a complete,
      unaltered age record is preserved. We tested potential influences on AGCs with a
      single experimental organism, a male Bogertophis subocularis, that was raised at
      a controlled temperature and with constant access to mice and water. The
      conditions in which this individual was maintained, including that it had yet to
      live through a full reproductive cycle, enabled us to determine that its AGCs
      reflect only the annual solar cycle, and neither temperature, nor resource
      availability, nor energy diversion to gametogenesis could explain that it still
      exhibited lines of arrested growth. Moreover, growth lines in this specimen are
      deposited toward the end of the growth season in the fall, and not in the winter,
      during which this individual continued to feed and grow, even though this mid
      latitude species would normally be hibernating and not growing. This suggests
      that growth lines are not caused by hibernation, but reflect the onset of a
      physiological cycle preparing Bogertophis subocularis for winter rest. That being
      said, hibernation and reproductive cycle could still influence the amount of time
      represented by an individual growth line. Growth-line number and AGC spacing
      pattern, plus centrum length, are used to estimate MNI of the Early Eocene fossil
      snake Boavus occidentalis collected from the Willwood Formation over two field
      seasons during the late 19th century. We identified eight or nine individuals
      among specimens previously parcelled among two specimen lots collected during
      those expeditions.

PMID- 29844973
TI  - Identifying potentially marker symptoms of attention-deficit/hyperactivity
      disorder.
AB  - Background: For the diagnosis of attention-deficit/hyperactivity disorder (ADHD),
      the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) proposes that
      adherence to six symptoms in either group (inattention and
      hyperactivity/impulsivity) will lead to the diagnosis of one of three
      presentations of the disorder. Underlying this diagnostic algorithm is the
      assumption that the 18 symptoms have equal relevance for the diagnosis of ADHD,
      all are equally severe, and all have the same power to detect the presence of the
      disorder in all its degrees of severity, without considering the possibility of
      using marker symptoms. However, several studies have suggested that ADHD symptoms
      differ in both their power to discriminate the presence of the disorder and the
      degree of severity they represent. The aim of the present study was to replicate
      the results of previous research by evaluating the discriminative capacity and
      relative severity of ADHD symptoms, as well as to extend the investigation of
      this topic to Spanish-speaking Latin American samples. Methods: The properties of
      ADHD symptoms rated by the parents of 474 Chilean children were analyzed. Symptom
      parameters were estimated using the graded response model. Results: The results
      suggest that symptoms of ADHD differ substantially in both the accuracy with
      which they reflect the presence of the disorder, and their relative severity.
      Symptoms "easily distracted by extraneous stimuli" and "have difficulty
      sustaining attention in tasks" (inattention) and "is on the go, acting as if
      driven by motor" (hyperactivity/impulsivity) were the most informative, and those
      with relatively lower severity thresholds. Discussion: The fact that symptoms
      differ substantially in the probability of being observed conditionally to the
      trait level suggests the need to refine the diagnostic process by weighting the
      severity of the symptom, and even to assess the possibility of defining ADHD
      marker symptoms, as has been done in other disorders.

PMID- 29844974
TI  - Molecular response of canola to salt stress: insights on tolerance mechanisms.
AB  - Canola (Brassica napus L.) is widely cultivated around the world for the
      production of edible oils and biodiesel fuel. Despite many canola varieties being
      described as 'salt-tolerant', plant yield and growth decline drastically with
      increasing salinity. Although many studies have resulted in better understanding
      of the many important salt-response mechanisms that control salt signaling in
      plants, detoxification of ions, and synthesis of protective metabolites, the
      engineering of salt-tolerant crops has only progressed slowly. Genetic
      engineering has been considered as an efficient method for improving the salt
      tolerance of canola but there are many unknown or little-known aspects regarding
      canola response to salinity stress at the cellular and molecular level. In order
      to develop highly salt-tolerant canola, it is essential to improve knowledge of
      the salt-tolerance mechanisms, especially the key components of the plant salt
      response network. In this review, we focus on studies of the molecular response
      of canola to salinity to unravel the different pieces of the salt response
      puzzle. The paper includes a comprehensive review of the latest studies,
      particularly of proteomic and transcriptomic analysis, including the most
      recently identified canola tolerance components under salt stress, and suggests
      what researchers should focus on in future studies.

PMID- 29844975
TI  - Immunogenicity evaluation of MS2 phage-mediated chimeric nanoparticle displaying
      an immunodominant B cell epitope of foot-and-mouth disease virus.
AB  - Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed
      animals that has caused tremendous economic losses worldwide. In this study, we
      designed a chimeric nanoparticles (CNPs) vaccine that displays the predominant
      epitope of the serotype O foot-and-mouth disease virus (FMDV) VP1 131-160 on the
      surface of MS2 phage. The recombinant protein was expressed in Escherichia Coli
      and can self-assemble into CNPs with diameter at 25-30 nm in vitro. A tandem
      repeat peptide epitopes (TRE) was prepared as control. Mice were immunized with
      CNPs, TRE and commercialized synthetic peptide vaccines (PepVac), respectively.
      The ELISA results showed that CNPs stimulated a little higher specific antibody
      levels to PepVac, but was significantly higher than the TRE groups. Moreover, the
      results from specific IFN-gamma responses and lymphocyte proliferation test
      indicated that CNP immunized mice exhibited significantly enhanced cellular
      immune response compared to TRE. These results suggested that the CNPs
      constructed in current study could be a potential alternative vaccine in future
      FMDV control.

PMID- 29844976
TI  - Evidence-based economic analysis demonstrates that ecosystem service benefits of
      water hyacinth management greatly exceed research and control costs.
AB  - Invasive species management can be a victim of its own success when decades of
      effective control cause memories of past harm to fade and raise questions of
      whether programs should continue. Economic analysis can be used to assess the
      efficiency of investing in invasive species control by comparing ecosystem
      service benefits to program costs, but only if appropriate data exist. We used a
      case study of water hyacinth (Eichhornia crassipes (Mart.) Solms), a nuisance
      floating aquatic plant, in Louisiana to demonstrate how comprehensive record
      keeping supports economic analysis. Using long-term data sets, we developed
      empirical and spatio-temporal simulation models of intermediate complexity to
      project invasive species growth for control and no-control scenarios. For
      Louisiana, we estimated that peak plant cover would be 76% higher without the
      substantial growth rate suppression (84% reduction) that appeared due primarily
      to biological control agents. Our economic analysis revealed that combined
      biological and herbicide control programs, monitored over an unusually long time
      period (1975-2013), generated a benefit-cost ratio of about 34:1 derived from the
      relatively modest costs of $124 million ($2013) compared to the $4.2 billion
      ($2013) in benefits to anglers, waterfowl hunters, boating-dependent businesses,
      and water treatment facilities over the 38-year analysis period. This work adds
      to the literature by: (1) providing evidence of the effectiveness of water
      hyacinth biological control; (2) demonstrating use of parsimonious spatio
      temporal models to estimate benefits of invasive species control; and (3)
      incorporating activity substitution into economic benefit transfer to avoid
      overstating benefits. Our study suggests that robust and cost-effective economic
      analysis is enabled by good record keeping and generalizable models that can
      demonstrate management effectiveness and promote social efficiency of invasive
      species control.

PMID- 29844977
TI  - On the efficiency of the genetic code after frameshift mutations.
AB  - Statistical and biochemical studies of the standard genetic code (SGC) have found
      evidence that the impact of mistranslations is minimized in a way that erroneous
      codes are either synonymous or code for an amino acid with similar polarity as
      the originally coded amino acid. It could be quantified that the SGC is optimized
      to protect this specific chemical property as good as possible. In recent work,
      it has been speculated that the multilevel optimization of the genetic code
      stands in the wider context of overlapping codes. This work tries to follow the
      systematic approach on mistranslations and to extend those analyses to the
      general effect of frameshift mutations on the polarity conservation of amino
      acids. We generated one million random codes and compared their average polarity
      change over all triplets and the whole set of possible frameshift mutations.
      While the natural code-just as for the point mutations-appears to be
      competitively robust against frameshift mutations as well, we found that both
      optimizations appear to be independent of each other. For both, better codes can
      be found, but it becomes significantly more difficult to find candidates that
      optimize all of these features-just like the SGC does. We conclude that the SGC
      is not only very efficient in minimizing the consequences of mistranslations, but
      rather optimized in amino acid polarity conservation for all three effects of
      code alteration, namely translational errors, point and frameshift mutations. In
      other words, our result demonstrates that the SGC appears to be much more than
      just "one in a million".

PMID- 29844978
TI  - Effects of preservation method on canine (Canis lupus familiaris) fecal
      microbiota.
AB  - Studies involving gut microbiome analysis play an increasing role in the
      evaluation of health and disease in humans and animals alike. Fecal sampling
      methods for DNA preservation in laboratory, clinical, and field settings can
      greatly influence inferences of microbial composition and diversity, but are
      often inconsistent and under-investigated between studies. Many laboratories have
      utilized either temperature control or preservation buffers for optimization of
      DNA preservation, but few studies have evaluated the effects of combining both
      methods to preserve fecal microbiota. To determine the optimal method for fecal
      DNA preservation, we collected fecal samples from one canine donor and stored
      aliquots in RNAlater, 70% ethanol, 50:50 glycerol:PBS, or without buffer at 25 
      degrees C, 4  degrees C, and -80  degrees C. Fecal DNA was extracted, quantified,
      and 16S rRNA gene analysis performed on Days 0, 7, 14, and 56 to evaluate changes
      in DNA concentration, purity, and bacterial diversity and composition over time.
      We detected overall effects on bacterial community of storage buffer (F-value =
      6.87, DF = 3, P < 0.001), storage temperature (F-value=1.77, DF = 3, P = 0.037),
      and duration of sample storage (F-value = 3.68, DF = 3, P < 0.001). Changes in
      bacterial composition were observed in samples stored in -80  degrees C without
      buffer, a commonly used method for fecal DNA storage, suggesting that simply
      freezing samples may be suboptimal for bacterial analysis. Fecal preservation
      with 70% ethanol and RNAlater closely resembled that of fresh samples, though
      RNAlater yielded significantly lower DNA concentrations (DF = 8.57, P < 0.001).
      Although bacterial composition varied with temperature and buffer storage, 70%
      ethanol was the best method for preserving bacterial DNA in canine feces,
      yielding the highest DNA concentration and minimal changes in bacterial diversity
      and composition. The differences observed between samples highlight the need to
      consider optimized post-collection methods in microbiome research.

PMID- 29844979
TI  - Taxonomic monograph of Oxygyne (Thismiaceae), rare achlorophyllous
      mycoheterotrophs with strongly disjunct distribution.
AB  - Oxygyne Schltr. (Thismiaceae) is a rare and little-known genus of achlorophyllous
      mycoheterotrophic perennial herbs with one of the most remarkable distributions
      of all angiosperm plant genera globally, being disjunct between Japan and West
      Central Africa. Each species is known only from a single location, and in most
      cases from a single specimen. This monographic study names, describes and maps
      two new species, Oxygyne duncanii Cheek from cloud forest in SW Region Cameroon
      and O. frankei Cheek from gallery forest in the Central African Republic,
      representing the first new Oxygyne species described from Africa in 112 years,
      and raising the number of described Oxygyne species from four to six. Oxygyne
      duncanii is remarkable for sharing more morphological characters with two of the
      three Japanese species (O. hyodoi C.Abe & Akasawa, O. shinzatoi (H. Ohashi)
      Tsukaya) than with the geographically much closer type species of the genus, O.
      triandra from Mt Cameroon. Based mainly on herbarium specimens and field
      observations made in Cameroon and Japan during a series of botanical surveys, we
      provide descriptions, synonymy, mapping and extinction risk assessments for each
      species of Oxygyne, together with keys to the genera of Thismiaceae and the
      species of Oxygyne. The subterranean structures of African Oxygyne are described
      for the first time, and found to be consistent with those of the Japanese
      species. We review and reject an earlier proposal that the Japanese species
      should be segregated from the African species as a separate genus, Saionia Hatus.
      The only character that separates the two disjunct species groups is now flower
      colour: blue or partly-blue in the Japanese species compared with orange-brown in
      the African species. Studies of the pollination biology and mycorrhizal partners
      of Oxygyne are still lacking. Two of the six species, O. triandra Schltr. and O.
      hyodoi, appear to be extinct, and the remaining four are assessed as Critically
      Endangered using the IUCN 2012 criteria. To avoid further extinction, an urgent
      requirement is for conservation management of the surviving species in the wild.
      Since few achlorophyllous mycoheterotrophs have been successfully cultivated from
      seed to maturity, ex situ conservation will not be viable for these species and
      protection in the wild is the only viable option. While natural habitat survives,
      further botanical surveys could yet reveal additional new species between Central
      Africa and Japan.

PMID- 29844980
TI  - The variable monoaminergic outcomes of cleaner fish brains when facing different
      social and mutualistic contexts.
AB  - The monoamines serotonin and dopamine are important neuromodulators present in
      the central nervous system, known to be active regulators of social behaviour in
      fish as in other vertebrates. Our aim was to investigate the region-specific
      brain monoaminergic differences arising when individual cleaners face a client
      (mutualistic context) compared to when they are introduced to another conspecific
      (conspecific context), and to understand the relevance of visual assessment
      compared to the impact of physical contact with any partner. We demonstrated that
      serotoninergic activity at the diencephalon responds mostly to the absence of
      physical contact with clients whereas cerebellar dopaminergic activity responds
      to actual cleaning engagement. We provide first insights on the brain's
      monoaminergic (region-specific) response variations, involved in the expression
      of cleaner fishes' mutualistic and conspecific behaviour. These results
      contribute to a better understanding of the monoaminergic activity in accordance
      to different socio-behavioural contexts.

PMID- 29844981
TI  - Predicting the potential distributions of the invasive cycad scale Aulacaspis
      yasumatsui (Hemiptera: Diaspididae) under different climate change scenarios and
      the implications for management.
AB  - Cycads are an ancient group of gymnosperms that are popular as landscaping
      plants, though nearly all of them are threatened or endangered in the wild. The
      cycad aulacaspis scale (CAS), Aulacaspis yasumatsui Takagi (Hemiptera:
      Diaspididae), has become one of the most serious pests of cycads in recent years;
      however, the potential distribution range and the management approach for this
      pest are unclear. A potential risk map of cycad aulacaspis scale was created
      based on occurrence data under different climatic conditions and topology factors
      in this study. Furthermore, the future potential distributions of CAS were
      projected for the periods 2050s and 2070s under three different climate change
      scenarios (GFDL-CM3, HADGEM2-AO and MIROC5) described in the Special Report on
      Emissions Scenarios of the IPCC (Intergovernmental Panel on Climate Change). The
      model suggested high environmental suitability for the continents of Asia and
      North America, where the species has already been recorded. The potential
      distribution expansions or reductions were also predicted under different climate
      change conditions. Temperature of Driest Quarter (Bio9) was the most important
      factor, explaining 48.1% of the distribution of the species. The results also
      suggested that highly suitable habitat for CAS would exist in the study area if
      the mean temperature of 15-20  degrees C in the driest quarter and a mean
      temperature of 25-28  degrees C the wettest quarter. This research provides a
      theoretical reference framework for developing policy to manage and control this
      invasive pest.

PMID- 29844982
TI  - Impact of input data (in)accuracy on overestimation of visible area in digital
      viewshed models.
AB  - Viewshed analysis is a GIS tool in standard use for more than two decades to
      perform numerous scientific and practical tasks. The reliability of the resulting
      viewshed model depends on the computational algorithm and the quality of the
      input digital surface model (DSM). Although many studies have dealt with
      improving viewshed algorithms, only a few studies have focused on the effect of
      the spatial accuracy of input data. Here, we compare simple binary viewshed
      models based on DSMs having varying levels of detail with viewshed models created
      using LiDAR DSM. The compared DSMs were calculated as the sums of digital terrain
      models (DTMs) and layers of forests and buildings with expertly assigned heights.
      Both elevation data and the visibility obstacle layers were prepared using
      digital vector maps differing in scale (1:5,000, 1:25,000, and 1:500,000) as well
      as using a combination of a LiDAR DTM with objects vectorized on an
      orthophotomap. All analyses were performed for 104 sample locations of 5 km2,
      covering areas from lowlands to mountains and including farmlands as well as
      afforested landscapes. We worked with two observer point heights, the first (1.8
      m) simulating observation by a person standing on the ground and the second (80
      m) as observation from high structures such as wind turbines, and with five
      estimates of forest heights (15, 20, 25, 30, and 35 m). At all height
      estimations, all of the vector-based DSMs used resulted in overestimations of
      visible areas considerably greater than those from the LiDAR DSM. In comparison
      to the effect from input data scale, the effect from object height estimation was
      shown to be secondary.

PMID- 29844983
TI  - Impact of crop residue management on crop production and soil chemistry after
      seven years of crop rotation in temperate climate, loamy soils.
AB  - Society is increasingly demanding a more sustainable management of agro
      ecosystems in a context of climate change and an ever growing global population.
      The fate of crop residues is one of the important management aspects under
      debate, since it represents an unneglectable quantity of organic matter which can
      be kept in or removed from the agro-ecosystem. The topic of residue management is
      not new, but the need for global conclusion on the impact of crop residue
      management on the agro-ecosystem linked to local pedo-climatic conditions has
      become apparent with an increasing amount of studies showing a diversity of
      conclusions. This study specifically focusses on temperate climate and loamy soil
      using a seven-year data set. Between 2008 and 2016, we compared four contrasting
      residue management strategies differing in the amount of crop residues returned
      to the soil (incorporation vs. exportation of residues) and in the type of
      tillage (reduced tillage (10 cm depth) vs. conventional tillage (ploughing at 25
      cm depth)) in a field experiment. We assessed the impact of the crop residue
      management on crop production (three crops-winter wheat, faba bean and maize
      cultivated over six cropping seasons), soil organic carbon content, nitrate
      ([Formula: see text]), phosphorus (P) and potassium (K) soil content and uptake
      by the crops. The main differences came primarily from the tillage practice and
      less from the restitution or removal of residues. All years and crops combined,
      conventional tillage resulted in a yield advantage of 3.4% as compared to reduced
      tillage, which can be partly explained by a lower germination rate observed under
      reduced tillage, especially during drier years. On average, only small
      differences were observed for total organic carbon (TOC) content of the soil, but
      reduced tillage resulted in a very clear stratification of TOC and also of P and
      K content as compared to conventional tillage. We observed no effect of residue
      management on the [Formula: see text] content, since the effect of fertilization
      dominated the effect of residue management. To confirm the results and enhance
      early tendencies, we believe that the experiment should be followed up in the
      future to observe whether more consistent changes in the whole agro-ecosystem
      functioning are present on the long term when managing residues with contrasted
      strategies.

PMID- 29844984
TI  - Shelters can negatively affect growth and welfare in lumpfish if feed is
      delivered continuously.
AB  - Due to the socioeconomic importance of salmon farming in the North Atlantic and
      the economic impact of sea lice in this industry, there is high demand for novel
      pest control methods. One such method is the use of cleaner fish to remove the
      lice from the salmon. A cleaner fish that has recently gained in popularity due
      to its ability to work in cold water, is the lumpfish (Cyclopterus lumpus). This
      fish varies in efficiency, but when mortality is low and cleaning optimal, the
      fish are successful in keeping parasite burdens low. However, there is some
      concern for the welfare of lumpfish in the industry, because mortality is often
      high. This is sometimes attributed to inadequate feeding and shelter. Here we
      compare growth, body condition, and fin health of fish reared for four weeks in a
      crossed treatment design crossing shelter availability (shelter vs none) and feed
      delivery method (manual meal time feeds and continuous automated feeding). In
      terms of weight gain, shelter availability interacted with feeding method, with
      fish that had access to shelters and were fed using automated feeders gaining
      less weight than other fish. Fin health was not affected, but body condition was
      lowered both by access to shelter and being fed continuously. The results
      indicate a need to carefully consider how feeding method and shelter use is
      combined, both in cages and during rearing on land.

PMID- 29844985
TI  - Divergent and convergent evolution of housekeeping genes in human-pig lineage.
AB  - Housekeeping genes are ubiquitously expressed and maintain basic cellular
      functions across tissue/cell type conditions. The present study aimed to develop
      a set of pig housekeeping genes and compare the structure, evolution and function
      of housekeeping genes in the human-pig lineage. By using RNA sequencing data, we
      identified 3,136 pig housekeeping genes. Compared with human housekeeping genes,
      we found that pig housekeeping genes were longer and subjected to slightly weaker
      purifying selection pressure and faster neutral evolution. Common housekeeping
      genes, shared by the two species, achieve stronger purifying selection than
      species-specific genes. However, pig- and human-specific housekeeping genes have
      similar functions. Some species-specific housekeeping genes have evolved
      independently to form similar protein active sites or structure, such as the
      classical catalytic serine-histidine-aspartate triad, implying that they have
      converged for maintaining the basic cellular function, which allows them to adapt
      to the environment. Human and pig housekeeping genes have varied structures and
      gene lists, but they have converged to maintain basic cellular functions
      essential for the existence of a cell, regardless of its specific role in the
      species. The results of our study shed light on the evolutionary dynamics of
      housekeeping genes.

PMID- 29844986
TI  - Selective constraint acting on TLR2 and TLR4 genes of Japanese Rana frogs.
AB  - Toll-like receptors (TLRs) are an important component of innate immunity, the
      first line of pathogen defence. One of the major roles of TLRs includes
      recognition of pathogen-associated molecular patterns. Amphibians are currently
      facing population declines and even extinction due to chytridiomycosis caused by
      the Batrachochytrium dendrobatidis (Bd) fungus. Evidence from other vertebrates
      shows that TLR2 and TLR4 are involved in innate immunity against various fungi.
      Such genes therefore may play a functional role in amphibian-chytridiomycosis
      dynamics. Frogs from East Asia appear to be tolerant to Bd, so we examined the
      genetic diversity that underlies TLR2 and TLR4 from three Japanese Ranidae frog
      species, Rana japonica, R. ornativentris and R. tagoi tagoi (n = 5 per species).
      We isolated 27 TLR2 and 20 TLR4 alleles and found that these genes are
      evolutionarily conserved, with overall evidence supporting purifying selection.
      In contrast, site-by-site analysis of selection identified several specific codon
      sites under positive selection, some of which were located in the variable
      leucine rich repeat domains. In addition, preliminary expression levels of TLR2
      and TLR4 from transcriptome data showed overall low expression. Although it
      remains unclear whether infectious pathogens are a selective force acting on TLRs
      of Japanese frogs, our results support that certain sites in TLRs of these
      species may have experienced pathogen-mediated selection.

PMID- 29844987
TI  - Rapid evolution of the Helicobacter pylori AlpA adhesin in a high gastric cancer
      risk region from Colombia.
AB  - To be able to survive, Helicobacter pylori must adhere to the gastric epithelial
      cells of its human host. For this purpose, the bacterium employs an array of
      adhesins, for example, AlpA. The adhesin AlpA has been proposed as a major
      adhesin because of its critical role in human stomach colonization. Therefore,
      understanding how AlpA evolved could be important for the development of new
      diagnostic strategies. However, the genetic variation and microevolutionary
      patterns of alpA have not been described in Colombia. The study aim was to
      describe the variation patterns and microevolutionary process of alpA in
      Colombian clinical isolates of H. pylori. The existing polymorphisms, which are
      deviations from the neutral model of molecular evolution, and the genetic
      differentiation of the alpA gene from Colombian clinical isolates of H. pylori
      were determined. The analysis shows that gene conversion and purifying selection
      have shaped the evolution of three different variants of alpA in Colombia.

PMID- 29844988
TI  - Primate occurrence across a human-impacted landscape in Guinea-Bissau and
      neighbouring regions in West Africa: using a systematic literature review to
      highlight the next conservation steps.
AB  - Background: West African landscapes are largely characterised by complex
      agroforest mosaics. Although the West African forests are considered a nonhuman
      primate hotspot, knowledge on the distribution of many species is often lacking
      and out-of-date. Considering the fast-changing nature of the landscapes in this
      region, up-to-date information on primate occurrence is urgently needed,
      particularly of taxa such as colobines, which may be more sensitive to habitat
      modification than others. Understanding wildlife occurrence and mechanisms of
      persistence in these human-dominated landscapes is fundamental for developing
      effective conservation strategies. Methods: In this paper, we aim to review
      current knowledge on the distribution of three threatened primates in Guinea
      Bissau and neighbouring regions, highlighting research gaps and identifying
      priority research and conservation action. We conducted a systematic literature
      review of primate studies from 1976 to 2016 in Guinea-Bissau, southern Senegal
      and western Guinea (Boke Region). We mapped historical observation records of
      chimpanzee (Pan troglodytes verus), Temminck's red colobus (Pilicolobus badius
      temminckii) and king colobus (Colobus polykomos), including our preliminary
      survey data from Dulombi, a newly established National Park (NP) in Guinea
      Bissau. Results: We found 151 documents, including 87 journal articles, that
      contained field data on primates in this region. In Guinea-Bissau, nearly all
      studies focussed south of the Corubal River, including mainly Cantanhez, Cufada,
      and Boe NP's. In Senegal, most of the data came from Fongoli and Niokolo-Koba NP.
      In Boke (Guinea) studies are few, with the most recent data coming from
      Sangaredi. In Dulombi NP we recorded eight primate species, including
      chimpanzees, red colobus and king colobus. Across the selected region,
      chimpanzees, red colobus and king colobus were reported in eleven, twelve and
      seven protected areas, respectively. Discussion: Our study demonstrates large
      geographical research gaps particularly for the two colobines. For the first time
      after more than two decades, we confirm the presence of red colobus and king
      colobus north of the Corubal River in Guinea-Bissau. The little information
      available from large parts of the red colobus range raises questions regarding
      levels of population fragmentation in this species, particularly in Casamance and
      across northern Guinea-Bissau. There are still no records demonstrating the
      occurrence of king colobus in Senegal, and the presence of a viable population in
      north-eastern Guinea-Bissau remains uncertain. While the occurrence of
      chimpanzees in Guinea-Bissau and Senegal is well documented, data from Boke
      (Guinea) are sparse and out-of-date. Our approach-the mapping of data gathered
      from a systematic literature review-allows us to provide recommendations for
      selecting future geographical survey locations and planning further research and
      conservation strategies in this region.

PMID- 29844989
TI  - The global burden of HIV-1 drug resistance in the past 20 years.
AB  - Genotypic drug resistance testing has been an integral part of the clinical
      management of HIV patients for almost 20 years, not only assisting treatment
      choices but also informing drug development. Accurate estimations on the
      worldwide circulation of drug resistance are difficult to obtain, particularly in
      low/middle-income countries. In this work, we queried two of the largest public
      HIV sequence repositories in the world-Los Alamos and Stanford HIVdb-to derive
      global prevalence, time trends and geodemographic predictors of HIV drug
      resistance. Different genotypic interpretation systems were used to ascertain
      resistance to reverse transcriptase and protease inhibitors. Continental, subtype
      specific (including circulating recombinant forms) stratification as well as
      analysis on drug-naive isolates were performed. Geographic information system
      analysis correlated country-specific drug resistance to sociodemographic and
      health indicators obtained from the World Bank. By looking at over 33,000
      sequences worldwide between 1996 and 2016, increasing drug resistance trends with
      non-B subtypes and recombinants were found; transmitted drug resistance appeared
      to remain stable in the last decade. While an increase in drug resistance is
      expected with antiretroviral therapy rollout in resource-constrained areas, the
      plateau effect in areas covered by the most modern drug regimens warns against
      the downgrading of the resistance issue.

PMID- 29844990
TI  - A survey on sleep assessment methods.
AB  - Purpose: A literature review is presented that aims to summarize and compare
      current methods to evaluate sleep. Methods: Current sleep assessment methods have
      been classified according to different criteria; e.g., objective
      (polysomnography, actigraphy...) vs. subjective (sleep questionnaires,
      diaries...), contact vs. contactless devices, and need for medical assistance vs.
      self-assessment. A comparison of validation studies is carried out for each
      method, identifying their sensitivity and specificity reported in the literature.
      Finally, the state of the market has also been reviewed with respect to
      customers' opinions about current sleep apps. Results: A taxonomy that classifies
      the sleep detection methods. A description of each method that includes the
      tendencies of their underlying technologies analyzed in accordance with the
      literature. A comparison in terms of precision of existing validation studies and
      reports. Discussion: In order of accuracy, sleep detection methods may be
      arranged as follows: Questionnaire < Sleep diary < Contactless devices < Contact
      devices < PolysomnographyA literature review suggests that current subjective
      methods present a sensitivity between 73% and 97.7%, while their specificity
      ranges in the interval 50%-96%. Objective methods such as actigraphy present a
      sensibility higher than 90%. However, their specificity is low compared to their
      sensitivity, being one of the limitations of such technology. Moreover, there are
      other factors, such as the patient's perception of her or his sleep, that can be
      provided only by subjective methods. Therefore, sleep detection methods should be
      combined to produce a synergy between objective and subjective methods. The
      review of the market indicates the most valued sleep apps, but it also identifies
      problems and gaps, e.g., many hardware devices have not been validated and
      (especially software apps) should be studied before their clinical use.

PMID- 29844991
TI  - Physical fitness predicts technical-tactical and time-motion profile in simulated
      Judo and Brazilian Jiu-Jitsu matches.
AB  - Background: Among combat sports, Judo and Brazilian Jiu-Jitsu (BJJ) present
      elevated physical fitness demands from the high-intensity intermittent efforts.
      However, information regarding how metabolic and neuromuscular physical fitness
      is associated with technical-tactical performance in Judo and BJJ fights is not
      available. This study aimed to relate indicators of physical fitness with combat
      performance variables in Judo and BJJ. Methods: The sample consisted of Judo (n =
      16) and BJJ (n = 24) male athletes. At the first meeting, the physical tests were
      applied and, in the second, simulated fights were performed for later notational
      analysis. Results: The main findings indicate: (i) high reproducibility of the
      proposed instrument and protocol used for notational analysis in a mobile device;
      (ii) differences in the technical-tactical and time-motion patterns between
      modalities; (iii) performance-related variables are different in Judo and BJJ;
      and (iv) regression models based on metabolic fitness variables may account for
      up to 53% of the variances in technical-tactical and/or time-motion variables in
      Judo and up to 31% in BJJ, whereas neuromuscular fitness models can reach values
      up to 44 and 73% of prediction in Judo and BJJ, respectively. When all components
      are combined, they can explain up to 90% of high intensity actions in Judo.
      Discussion: In conclusion, performance prediction models in simulated combat
      indicate that anaerobic, aerobic and neuromuscular fitness variables contribute
      to explain time-motion variables associated with high intensity and technical
      tactical variables in Judo and BJJ fights.

PMID- 29844992
TI  - Effect of Sofosbuvir plus Ribavirin therapy on hepatitis C patients in Pakistan:
      a retrospective study.
AB  - Background: The annual global deaths from viral hepatitis is 1.4 million.
      Pakistan has the second highest burden of hepatitis C in the world. There is dire
      need to evaluate the response of new direct acting antivirals for the treatment
      of hepatitis C patients in Pakistan. World Health Organization has developed a
      strategy to treat 80% of HCV patients by 2030. In Pakistan, HCV treatment rate is
      1%. The aim of the study was to analyze the effect of Sofosbuvir plus Ribavirin
      therapy on HCV patients in Pakistan. Methods: An observational study was
      conducted at Fauji Foundation Hospital Rawalpindi from November-2016 to July
      2017. All the drugs were administered according to the guidelines of Asia Pacific
      Association for the Study of Liver (APASL) for the treatment of HCV patients. A
      total 327 chronic HCV patients were enrolled in the study and 304 completed the
      treatment. Patients belonged to three different groups including treatment: Naive
      patients (n = 107), Non-Responder patients (n = 126) and patients who relapsed to
      Interferon therapy (n = 71). All the patients were given Sofosbuvir plus
      Ribavirin therapy for 24 weeks and the early virological response (EVR) and end
      treatment response (ETR) was calculated. Different parameters including patient
      age, viral load, viral genotype, blood picture, ultrasound findings and liver
      function tests were also studied. Results: Out of 304 patients, 301 (99%)
      achieved EVR and 300 achieved ETR (98.7%). End treatment response was 95.6% in
      HCV genotype 1 and 98.9% in HCV genotype 3 patients. ETR was 99.06% in treatment
      Naive, 99.20% in non-responders and 97.18% in previously relapsed patients. We
      did not find the association of any host and viral factor in the determination of
      EVR and ETR. Conclusion: The Sofosbuvir plus Ribavirin treatment is highly
      effective, safe and cost-effective for the treatment of hepatitis C patients in
      Pakistan.

PMID- 29844993
TI  - Altitudinal patterns in breeding bird species richness and density in relation to
      climate, habitat heterogeneity, and migration influence in a temperate montane
      forest (South Korea).
AB  - Altitudinal patterns in the population ecology of mountain bird species are
      useful for predicting species occurrence and behavior. Numerous hypotheses about
      the complex interactions among environmental factors have been proposed; however,
      these still remain controversial. This study aimed to identify the altitudinal
      patterns in breeding bird species richness or density and to test the hypotheses
      that climate, habitat heterogeneity (horizontal and vertical), and heterospecific
      attraction in a temperate forest, South Korea. We conducted a field survey of 142
      plots at altitudes between 200 and 1,400 m a.s.l in the breeding season. A total
      of 2,771 individuals from 53 breeding bird species were recorded. Altitudinal
      patterns of species richness and density showed a hump-shaped pattern, indicating
      that the highest richness and density could be observed at moderate altitudes.
      Models constructed with 13 combinations of six variables demonstrated that
      species richness was positively correlated with vertical and horizontal habitat
      heterogeneity. Density was positively correlated with vertical, but not
      horizontal habitat heterogeneity, and negatively correlated with migratory bird
      ratio. No significant relationships were found between spring temperature and
      species richness or density. Therefore, the observed patterns in species richness
      support the hypothesis that habitat heterogeneity, rather than climate, is the
      main driver of species richness. Also, neither habitat heterogeneity nor climate
      hypotheses fully explains the observed patterns in density. However, vertical
      habitat heterogeneity does likely help explain observed patterns in density. The
      heterospecific attraction hypothesis did not apply to the distribution of birds
      along the altitudinal gradient. Appropriate management of vertical habitat
      heterogeneity, such as vegetation cover, should be maintained for the
      conservation of bird diversity in this area.

PMID- 29844994
TI  - Allocation pattern and accumulation potential of carbon stock in natural spruce
      forests in northwest China.
AB  - Background: The spruce forests are dominant communities in northwest China, and
      play a key role in national carbon budgets. However, the patterns of carbon stock
      distribution and accumulation potential across stand ages are poorly documented.
      Methods: We investigated the carbon stocks in biomass and soil in the natural
      spruce forests in the region by surveys on 39 plots. Biomass of tree components
      were estimated using allometric equations previously established based on tree
      height and diameter at breast height, while biomass in understory (shrub and
      herb) and forest floor were determined by total harvesting method. Fine root
      biomass was estimated by soil coring technique. Carbon stocks in various biomass
      components and soil (0-100 cm) were estimated by analyzing the carbon content of
      each component. Results: The results showed that carbon stock in these forest
      ecosystems can be as high as 510.1 t ha-1, with an average of 449.4 t ha-1.
      Carbon stock ranged from 28.1 to 93.9 t ha-1 and from 0.6 to 8.7 t ha-1 with
      stand ages in trees and deadwoods, respectively. The proportion of shrubs, herbs,
      fine roots, litter and deadwoods ranged from 0.1% to 1% of the total ecosystem
      carbon, and was age-independent. Fine roots and deadwood which contribute to
      about 2% of the biomass carbon should be attached considerable weight in the
      investigation of natural forests. Soil carbon stock did not show a changing trend
      with stand age, ranging from 254.2 to 420.0 t ha-1 with an average of 358.7 t ha
      1. The average value of carbon sequestration potential for these forests was
      estimated as 29.4 t ha-1, with the lower aged ones being the dominant
      contributor. The maximum carbon sequestration rate was 2.47 t ha-1 year-1
      appearing in the growth stage of 37-56 years. Conclusion: The carbon stock in
      biomass was the major contributor to the increment of carbon stock in ecosystems.
      Stand age is not a good predictor of soil carbon stocks and accurate evaluation
      of the soil carbon dynamics thus requires long-term monitoring in situ. The
      results not only revealed carbon stock status and dynamics in these natural
      forests but were helpful to understand the role of Natural Forest Protection
      project in forest carbon sequestration as well.

PMID- 29844995
TI  - On the taxonomic status and distribution of African species of Otomops
      (Chiroptera: Molossidae).
AB  - Background: Free-tailed bats of the genus Otomops are poorly known, and most
      species are documented from a handful of widely scattered localities. Recently,
      two allopatric species of Otomops were recognized in continental Africa: Otomops
      martiensseni (Matschie, 1897) in southern, central and western Africa, and the
      new species O. harrisoni Ralph et al., 2015 in the northeast and in Yemen.
      Methods: We collected additional samples of Otomops in Kenya and Rwanda where the
      ranges of these taxa approach one another to clarify their geographic ranges and
      taxonomic status. Mitochondrial and nuclear intron sequences served to identify
      and delimit species; we also documented their echolocation call variation and
      ectoparasite complements. Results: Otomops martiensseni, the southern African
      species, was documented in northern Kenya in Marsabit National Park. O.
      harrisoni, the northeastern African-Arabian species, was documented in southern
      Kenya and in a cave in Musanze District, Rwanda. Moreover, individuals of both
      species were found together at the Musanze cave, establishing them in precise
      spatial and temporal sympatry. Analyses of mitochondrial and nuclear loci
      identify no evidence of admixture between these forms, although available samples
      limit the power of this analysis. Echolocation call differences are also apparent
      among the three localities we analyzed. Three orders of insects and two families
      of mites are newly reported as ectoparasites of O. harrisoni. Discussion: Our
      results corroborate species rank for O. harrisoni and establish a zone of
      potential geographic overlap with O. martiensseni spanning at least 800 km of
      latitude. The new records establish the species in sympatry in northern Rwanda
      and add an additional species to the bat faunas of both Kenya and Rwanda. Future
      studies are needed to understand Otomops roosting requirements and movements,
      thereby explaining the paucity of known colonies and yielding better estimates of
      their conservation status. The discovery of mixed roosting associations in Rwanda
      invites further investigation.

PMID- 29844996
TI  - Why is nonword reading so variable in adult skilled readers?
AB  - When the task is reading nonwords aloud, skilled adult readers are very variable
      in the responses they produce: a nonword can evoke as many as 24 different
      responses in a group of such readers. Why is nonword reading so variable? We
      analysed a large database of reading responses to nonwords, which documented that
      two factors contribute to this variability. The first factor is variability in
      graphemic parsing (the parsing of a letter string into its constituent
      graphemes): the same nonword can be graphemically parsed in different ways by
      different readers. The second factor is phoneme assignment: even when all
      subjects produce the same graphemic parsing of a nonword, they vary in what
      phonemes they assign to the resulting set of graphemes. We consider the
      implications of these results for the computational modelling of reading, for the
      assessment of impairments of nonword reading, and for the study of reading aloud
      in other alphabetically written languages and in nonalphabetic writing systems.

PMID- 29844997
TI  - Identification of stem rust resistance genes in wheat cultivars in China using
      molecular markers.
AB  - Wheat stem rust caused by Puccinia graminis f. sp. tritici Eriks. & E. Henn.
      (Pgt), is a major disease that has been effectively controlled using resistance
      genes. The appearance and spread of Pgt races such as Ug99, TKTTF, and TTTTF,
      which are virulent to most stem rust-resistant genes currently deployed in wheat
      breeding programs, renewed the interest in breeding cultivars resistant to wheat
      stem rust. It is therefore important to investigate the levels of resistance or
      vulnerability of wheat cultivars to Pgt races. Resistance to Pgt races 21C3CTHQM,
      34MKGQM, and 34C3RTGQM was evaluated in 136 Chinese wheat cultivars at the
      seedling stage. A total of 124 cultivars (91.2%) were resistant to the three
      races. Resistance genes Sr2, Sr24, Sr25, Sr26, Sr31, and Sr38 were analyzed using
      molecular markers closely linked to them, and 63 of the 136 wheat cultivars
      carried at least one of these genes: 21, 25, and 28 wheat cultivars likely
      carried Sr2, Sr31, and Sr38, respectively. Cultivars "Kehan 3" and "Jimai 22"
      likely carried Sr25. None of the cultivars carried Sr24 or Sr26. These cultivars
      with known stem rust resistance genes provide valuable genetic material for
      breeding resistant wheat cultivars.

PMID- 29844998
TI  - Reef fish communities are spooked by scuba surveys and may take hours to recover.
AB  - Ecological monitoring programs typically aim to detect changes in the abundance
      of species of conservation concern or which reflect system status. Coral reef
      fish assemblages are functionally important for reef health and these are most
      commonly monitored using underwater visual surveys (UVS) by divers. In addition
      to estimating numbers, most programs also collect estimates of fish lengths to
      allow calculation of biomass, an important determinant of a fish's functional
      impact. However, diver surveys may be biased because fishes may either avoid or
      are attracted to divers and the process of estimating fish length could result in
      fish counts that differ from those made without length estimations. Here we
      investigated whether (1) general diver disturbance and (2) the additional task of
      estimating fish lengths affected estimates of reef fish abundance and species
      richness during UVS, and for how long. Initial estimates of abundance and species
      richness were significantly higher than those made on the same section of reef
      after diver disturbance. However, there was no evidence that estimating fish
      lengths at the same time as abundance resulted in counts different from those
      made when estimating abundance alone. Similarly, there was little consistent bias
      among observers. Estimates of the time for fish taxa that avoided divers after
      initial contact to return to initial levels of abundance varied from three to 17
      h, with one group of exploited fishes showing initial attraction to divers that
      declined over the study period. Our finding that many reef fishes may disperse
      for such long periods after initial contact with divers suggests that monitoring
      programs should take great care to minimise diver disturbance prior to surveys.

PMID- 29844999
TI  - Do latitudinal gradients exist in New Zealand stream invertebrate
      metacommunities?
AB  - That biodiversity declines with latitude is well known, but whether a
      metacommunity process is behind this gradient has received limited attention. We
      tested the hypothesis that dispersal limitation is progressively replaced by mass
      effects with increasing latitude, along with a series of related hypotheses. We
      explored these hypotheses by examining metacommunity structure in stream
      invertebrate metacommunities spanning the length of New Zealand's two largest
      islands (~1,300 km), further disentangling the role of dispersal by
      deconstructing assemblages into strong and weak dispersers. Given the highly
      dynamic nature of New Zealand streams, our alternative hypothesis was that these
      systems are so unpredictable (at different stages of post-flood succession) that
      metacommunity structure is highly context dependent from region to region. We
      rejected our primary hypotheses, pinning this lack of fit on the strong
      unpredictability of New Zealand's dynamic stream ecosystems and fauna that has
      evolved to cope with these conditions. While local community structure turned
      over along this latitudinal gradient, metacommunity structure was highly context
      dependent and dispersal traits did not elucidate patterns. Moreover, the emergent
      metacommunity types exhibited no trends, nor did the important environmental
      variables. These results provide a cautionary tale for examining singular
      metacommunities. The considerable level of unexplained contingency suggests that
      any inferences drawn from one-off snapshot sampling may be misleading and further
      points to the need for more studies on temporal dynamics of metacommunity
      processes.

PMID- 29845000
TI  - Pituitary Abscess: A Rare Clinical Entity in the Presence of Acute
      Rhinosinusitis: A Case Report.
AB  - A pituitary abscess is an often-overlooked diagnosis in the clinical presentation
      of a sellar mass. Due to its rare incidence and nonspecific presentation,
      diagnosis and treatment is often delayed. The authors describe a 56-year-old male
      patient presenting with acute onset of severe headache, visual field deficit, and
      radiologic findings of an expansile sellar lesion. The presenting symptoms were
      unremarkable for the diagnosis of meningitis, cavernous sinus thrombosis, and
      septicemia. Recent medical history included symptoms of rhinosinusitis on the
      days preceding his acute presentation. The initial clinical presentation was
      suggestive of a possible pituitary apoplexy. Intraoperative findings revealed
      purulent output upon surgical entry of the sella. Histopathology confirmed the
      diagnosis of a pituitary abscess. Review of the clinical and radiologic data
      revealed evidence of multiple opacifications within the paranasal sinuses, along
      with dehiscence overlying the sellar bone, supporting a diagnosis of secondary
      pituitary abscess. This case, along with a review of the available literature,
      will serve to expand our knowledge of this rare disease process that is often
      overlooked. Clinicians should be mindful of this condition, and include a primary
      versus secondary pituitary abscess in the differential workup on such cases.

PMID- 29845001
TI  - Giant Cell Tumor of the Lateral Skull Base: Diagnostic and Management Options.
AB  - Giant cell tumor of bone (GCTB) is a rare, benign, osteolytic neoplasm that most
      commonly occurs in early adulthood and often involves the long bones of the body.
      Although GCTB largely affects the epiphyses of long bones, several reports of
      GCTB involvement of the cranial and facial bones exist in the literature. In
      addition to reviewing other reported cases of GCTBs of the lateral skull base in
      the literature, the authors report here on the clinical presentation,
      radiographic findings, and neurosurgical management of a patient found to have a
      GCTB of the middle and infratemporal fossae, which was treated by aggressive en
      bloc resection of the lateral skull base.

PMID- 29845002
TI  - Rituximab for retroperitoneal fibrosis due to IgG4-related disease: A case report
      and literature review.
AB  - Retroperitoneal fibrosis (RPF) is a progressive fibroinflammatory disease that
      can be complicated by urinary obstruction. RPF can be the only manifestation of
      IgG4-related disease (IgG4-RD). Treatment of IgG4-related RPF is challenging and
      mostly consists of long-term glucocorticoids leading to significant side effects
      and treatment intolerance. Recent exploration of the role of rituximab as a B
      cell depleting therapy in the treatment of IgG4-RD provides therapeutic potential
      as a well-tolerated alternative to glucocorticoids. We present a case of IgG4
      related RPF for which rituximab was instituted as a steroid-sparing treatment
      strategy. Following 4 doses, kidney function partially recovered, and the disease
      went into remission. We discuss the potential merit of rituximab for the
      treatment of patients with IgG4-related RPF.

PMID- 29845003
TI  - Early bilateral and massive compromise of the frontal lobes.
AB  - The frontal lobes are one of the most complex brain structures involved in both
      domain-general and specific functions. The goal of this work was to assess the
      anatomical and cognitive affectations from a unique case with massive bilateral
      frontal affectation. We report the case of GC, an eight-year old child with
      nearly complete affectation of bilateral frontal structures and spared temporal,
      parietal, occipital, and cerebellar regions. We performed behavioral,
      neuropsychological, and imaging (MRI, DTI, fMRI) evaluations. Neurological and
      neuropsychological examinations revealed a mixed pattern of affected (executive
      control/abstraction capacity) and considerably preserved (consciousness,
      language, memory, spatial orientation, and socio-emotional) functions. Both
      structural (DTI) and functional (fMRI) connectivity evidenced abnormal anterior
      connections of the amygdala and parietal networks. In addition, brain structural
      connectivity analysis revealed almost complete loss of frontal connections, with
      atypical temporo-posterior pathways. Similarly, functional connectivity showed an
      aberrant frontoparietal network and relative preservation of the posterior part
      of the default mode network and the visual network. We discuss this multilevel
      pattern of behavioral, structural, and functional connectivity results. With its
      unique pattern of compromised and preserved structures and functions, this
      exceptional case offers new constraints and challenges for neurocognitive
      theories.

PMID- 29845004
TI  - Abnormal language-related oscillatory responses in primary progressive aphasia.
AB  - Patients with Primary Progressive Aphasia (PPA) may react to linguistic stimuli
      differently than healthy controls, reflecting degeneration of language networks
      and engagement of compensatory mechanisms. We used magnetoencephalography (MEG)
      to evaluate oscillatory neural responses in sentence comprehension, in patients
      with PPA and age-matched controls. Participants viewed sentences containing
      semantically and syntactically anomalous words that evoke distinct oscillatory
      responses. For age-matched controls, semantic anomalies elicited left-lateralized
      8-30 Hz power decreases distributed along ventral brain regions, whereas
      syntactic anomalies elicited bilateral power decreases in both ventral and dorsal
      regions. In comparison to controls, patients with PPA showed altered patterns of
      induced oscillations, characterized by delayed latencies and attenuated
      amplitude, which were correlated with linguistic impairment measured offline. The
      recruitment of right hemisphere temporo-parietal areas (also found in controls)
      was correlated with preserved semantic processing abilities, indicating that
      preserved neural activity in these regions was able to support successful
      semantic processing. In contrast, syntactic processing was more consistently
      impaired in PPA, regardless of neural activity patterns, suggesting that this
      domain of language is particularly vulnerable to the neuronal loss. In addition,
      we found that delayed peak latencies of oscillatory responses were associated
      with lower accuracy for detecting semantic anomalies, suggesting that language
      deficits observed in PPA may be linked to delayed or slowed information
      processing.

PMID- 29845005
TI  - Psychopathic traits linked to alterations in neural activity during personality
      judgments of self and others.
AB  - Psychopathic individuals are notorious for their grandiose sense of self-worth
      and disregard for the welfare of others. One potential psychological mechanism
      underlying these traits is the relative consideration of "self" versus "others".
      Here we used task-based functional magnetic resonance imaging (fMRI) to identify
      neural responses during personality trait judgments about oneself and a familiar
      other in a sample of adult male incarcerated offenders (n = 57). Neural activity
      was regressed on two clusters of psychopathic traits: Factor 1 (e.g.,
      egocentricity and lack of empathy) and Factor 2 (e.g., impulsivity and
      irresponsibility). Contrary to our hypotheses, Factor 1 scores were not
      significantly related to neural activity during self- or other-judgments.
      However, Factor 2 traits were associated with diminished activation to self
      judgments, in relation to other-judgments, in bilateral posterior cingulate
      cortex and right temporoparietal junction. These findings highlight cortical
      regions associated with a dimension of social-affective cognition that may
      underlie psychopathic individuals' impulsive traits.

PMID- 29845006
TI  - Decreased functional connectivity in the fronto-parietal network in children with
      mood disorders compared to children with dyslexia during rest: An fMRI study.
AB  - Background: The DSM-5 separates the diagnostic criteria for mood and behavioral
      disorders. Both types of disorders share neurocognitive deficits of executive
      function and reading difficulties in childhood. Children with dyslexia also have
      executive function deficits, revealing a role of executive function circuitry in
      reading. The aim of the current study is to determine whether there is a
      significant relationship of functional connectivity within the fronto-parietal
      and cingulo-opercular cognitive control networks to reading measures for children
      with mood disorders, behavioral disorders, dyslexia, and healthy controls (HC).
      Method: Behavioral reading measures of phonological awareness, decoding, and
      orthography were collected. Resting state fMRI data were collected, preprocessed,
      and then analyzed for functional connectivity. Differences in the reading
      measures were tested for significance among the groups. Global efficiency (GE)
      measures were also tested for correlation with reading measures in 40 children
      with various disorders and 17 HCs. Results: Significant differences were found
      between the four groups on all reading measures. Relative to HCs and children
      with mood disorders or behavior disorders, children with dyslexia as a primary
      diagnosis scored significantly lower on all three reading measures. Children with
      mood disorders scored significantly lower than controls on a test of phonological
      awareness. Phonological awareness deficits correlated with reduced resting state
      functional connectivity MRI (rsfcMRI) in the cingulo-opercular network for
      children with dyslexia. A significant difference was also found in fronto
      parietal global efficiency in children with mood disorders relative to the other
      three groups. We also found a significant difference in cingulo-opercular global
      efficiency in children with mood disorders relative to the Dyslexia and Control
      groups. However, none of these differences correlate significantly with reading
      measures. Conclusions/significance: Reading difficulties involve abnormalities in
      different cognitive control networks in children with dyslexia compared to
      children with mood disorders. Findings of the current study suggest increased
      functional connectivity of one cognitive control network may compensate for
      reduced functional connectivity in the other network in children with mood
      disorders. These findings provide guidance to clinical professionals for design
      of interventions tailored for children suffering from reading difficulties
      originating from different pathologies.

PMID- 29845007
TI  - Gray matter changes in asymptomatic C9orf72 and GRN mutation carriers.
AB  - Frontotemporal dementia (FTD) is a neurodegenerative disease with a strong
      genetic basis. Understanding the structural brain changes during pre-symptomatic
      stages may allow for earlier diagnosis of patients suffering from FTD; therefore,
      we investigated asymptomatic members of FTD families with mutations in C9orf72
      and granulin (GRN) genes. Clinically asymptomatic subjects from families with
      C9orf72 mutation (15 mutation carriers, C9orf72+; and 23 non-carriers, C9orf72-)
      and GRN mutations (9 mutation carriers, GRN+; and 15 non-carriers, GRN-)
      underwent structural neuroimaging (MRI). Cortical thickness and subcortical gray
      matter volumes were calculated using FreeSurfer. Group differences were
      evaluated, correcting for age, sex and years to mean age of disease onset within
      the subject's family. Mean age of C9orf72+ and C9orf72- were 42.6 +/- 11.3 and
      49.7 +/- 15.5 years, respectively; while GRN+ and GRN- groups were 50.1 +/- 8.7
      and 53.2 +/- 11.2 years respectively. The C9orf72+ group exhibited cortical
      thinning in the temporal, parietal and frontal regions, as well as reduced
      volumes of bilateral thalamus and left caudate compared to the entire group of
      mutation non-carriers (NC: C9orf72- and GRN- combined). In contrast, the GRN+
      group did not show any significant differences compared to NC. C9orf72 mutation
      carriers demonstrate a pattern of reduced gray matter on MRI prior to symptom
      onset compared to GRN mutation carriers. These findings suggest that the
      preclinical course of FTD differs depending on the genetic basis and that the
      choice of neuroimaging biomarkers for FTD may need to take into account the
      specific genes involved in causing the disease.

PMID- 29845008
TI  - Locally stable brain states predict suppression of epileptic activity by enhanced
      cognitive effort.
AB  - Cognitive effort is known to play a role in healthy brain state organization, but
      little is known about its effects on pathological brain dynamics. When cortical
      stimulation is used to map functional brain areas prior to surgery, a common
      unwanted side effect is the appearance of afterdischarges (ADs), epileptiform and
      potentially epileptogenic discharges that can progress to a clinical seizure. It
      is therefore desirable to suppress this activity. Here, we analyze
      electrocorticography recordings from 15 patients with epilepsy. We show that a
      cognitive intervention in the form of asking an arithmetic question can be
      effective in suppressing ADs, but that its effectiveness is dependent upon the
      brain state at the time of intervention. By applying novel techniques from
      network analysis to quantify brain states, we find that the spatial organization
      of ADs with respect to coherent brain regions relates to the success of the
      cognitive intervention: if ADs are mainly localized within a single stable brain
      region, a cognitive intervention is likely to suppress the ADs. These findings
      show that cognitive effort is a useful tactic to modify unstable pathological
      activity associated with epilepsy, and suggest that the success of therapeutic
      interventions to alter activity may depend on an individual's brain state at the
      time of intervention.

PMID- 29845009
TI  - Connectivity-enhanced diffusion analysis reveals white matter density disruptions
      in first episode and chronic schizophrenia.
AB  - Reduced fractional anisotropy (FA) is a well-established correlate of
      schizophrenia, but it remains unclear whether these tensor-based differences are
      the result of axon damage and/or organizational changes and whether the changes
      are progressive in the adult course of illness. Diffusion MRI data were collected
      in 81 schizophrenia patients (54 first episode and 27 chronic) and 64 controls.
      Analysis of FA was combined with "fixel-based" analysis, the latter of which
      leverages connectivity and crossing-fiber information to assess both fiber bundle
      density and organizational complexity (i.e., presence and magnitude of off-axis
      diffusion signal). Compared with controls, patients with schizophrenia displayed
      clusters of significantly lower FA in the bilateral frontal lobes, right dorsal
      centrum semiovale, and the left anterior limb of the internal capsule. All FA
      based group differences overlapped substantially with regions containing complex
      fiber architecture. FA within these clusters was positively correlated with
      principal axis fiber density, but inversely correlated with both
      secondary/tertiary axis fiber density and voxel-wise fiber complexity. Crossing
      fiber complexity had the strongest (inverse) association with FA (r = -0.82).
      When crossing fiber structure was modeled in the MRtrix fixel-based analysis
      pipeline, patients exhibited significantly lower fiber density compared to
      controls in the dorsal and posterior corpus callosum (central, postcentral, and
      forceps major). Findings of lower FA in patients with schizophrenia likely
      reflect two inversely related signals: reduced density of principal axis fiber
      tracts and increased off-axis diffusion sources. Whereas the former confirms at
      least some regions where myelin and or/axon count are lower in schizophrenia, the
      latter indicates that the FA signal from principal axis fiber coherence is
      broadly contaminated by macrostructural complexity, and therefore does not
      necessarily reflect microstructural group differences. These results underline
      the need to move beyond tensor-based models in favor of acquisition and analysis
      techniques that can help disambiguate different sources of white matter
      disruptions associated with schizophrenia.

PMID- 29845010
TI  - Disrupted functional connectivity in primary progressive apraxia of speech.
AB  - Apraxia of speech is a motor speech disorder thought to result from impaired
      planning or programming of articulatory movements. It can be the initial or only
      manifestation of a degenerative disease, termed primary progressive apraxia of
      speech (PPAOS). The aim of this study was to use task-free functional magnetic
      resonance imaging (fMRI) to assess large-scale brain network pathophysiology in
      PPAOS. Twenty-two PPAOS participants were identified from a prospective cohort of
      degenerative speech and language disorders patients. All participants had a
      comprehensive, standardized evaluation including an evaluation by a speech
      language pathologist, examination by a behavioral neurologist and a multimodal
      imaging protocol which included a task-free fMRI sequence. PPAOS participants
      were age and sex matched to amyloid-negative, cognitively normal participants
      with a 1:2 ratio. We chose a set of hypothesis driven, predefined intrinsic
      connectivity networks (ICNs) from a large, out of sample independent component
      analysis and then used them to initialize a spatiotemporal dual regression to
      estimate participant level connectivity within these ICNs. Specifically, we
      evaluated connectivity within the speech and language, face and hand
      sensorimotor, left working memory, salience, superior parietal, supramarginal,
      insular and deep gray ICNs in a multivariate manner. The spatial maps for each
      ICN were then compared between PPAOS and control participants. We used clinical
      measures of apraxia of speech severity to assess for clinical-connectivity
      correlations for regions found to differ between PPAOS and control participants.
      Compared to controls, PPAOS participants had reduced connectivity of the right
      supplementary motor area and left posterior temporal gyrus to the rest of the
      speech and language ICN. The connectivity of the right supplementary motor area
      correlated negatively with an articulatory error score. PPAOS participants also
      had reduced connectivity of the left supplementary motor area to the face
      sensorimotor ICN, between the left lateral prefrontal cortex and the salience ICN
      and between the left temporal-occipital junction and the left working memory ICN.
      The latter connectivity correlated with the apraxia of speech severity rating
      scale, although the finding did not survive correction for multiple comparisons.
      Increased connectivity was noted in PPAOS participants between the dorsal
      posterior cingulate and the left working memory ICN. Our results support the
      importance of the supplementary motor area in the pathophysiology of PPAOS, which
      appears to be disconnected from speech and language regions. Supplementary motor
      area connectivity may serve as a biomarker of degenerative apraxia of speech
      severity.

PMID- 29845011
TI  - Serotonergic dysregulation is linked to sleep problems in Parkinson's disease.
AB  - Introduction: Sleep disturbances are common non-motor symptoms in Parkinson's
      disease (PD). Experimental studies suggest involvement of the serotonergic system
      in the regulation of sleep and arousal. Using [11C]DASB positron emission
      tomography, a marker of serotonin transporter availability, we investigated
      whether sleep dysfunction is associated with serotonergic dysfunction in PD.
      Methods: We studied 14 PD patients with sleep dysfunction, 14 PD without sleep
      dysfunction, and 12 healthy controls. Groups were matched for age, disease
      duration, severity of motor symptoms, daily intake of levodopa equivalent units,
      body-mass-index, depression and fatigue. [11C]DASB non-displaceable binding
      potential (BPND) was calculated for regions with a role in the regulation of
      sleep and arousal. Results: [11C]DASB BPND was reduced by 32-49% in PD patients
      with sleep dysfunction, and 14-25% in PD without sleep dysfunction, compared to
      healthy controls. PD patients with sleep dysfunction had lower [11C]DASB BPND in
      caudate (P < 0.01), putamen (P < 0.001), ventral striatum (P < 0.001), thalamus
      (P < 0.05), hypothalamus (P < 0.001) and raphe nuclei (P < 0.01), compared to PD
      without sleep dysfunction. Higher severity of sleep symptoms (assessed with
      Parkinson Disease Sleep Scale) correlated with lower [11C]DASB binding in caudate
      (r = 0.77; P < 0.001), putamen (r = 0.84; P < 0.001), ventral striatum (r = 0.86;
      P < 0.001), thalamus (r = 0.79; P < 0.001), hypothalamus (r = 0.90; P < 0.001)
      and raphe nuclei (r = 0.83; P < 0.001). Conclusions: Our findings demonstrate
      that sleep dysfunction in PD is associated with reduced serotonergic function in
      the midbrain raphe, basal ganglia and hypothalamus. Strategies to increase
      serotonin levels in the brain could be a promising approach to treat sleep
      dysfunction in PD, and may also have relevance in other neurodegenerative
      disorders.

PMID- 29845012
TI  - DEWS (DEep White matter hyperintensity Segmentation framework): A fully automated
      pipeline for detecting small deep white matter hyperintensities in migraineurs.
AB  - Migraineurs show an increased load of white matter hyperintensities (WMHs) and
      more rapid deep WMH progression. Previous methods for WMH segmentation have
      limited efficacy to detect small deep WMHs. We developed a new fully automated
      detection pipeline, DEWS (DEep White matter hyperintensity Segmentation
      framework), for small and superficially-located deep WMHs. A total of 148 non
      elderly subjects with migraine were included in this study. The pipeline consists
      of three components: 1) white matter (WM) extraction, 2) WMH detection, and 3)
      false positive reduction. In WM extraction, we adjusted the WM mask to re-assign
      misclassified WMHs back to WM using many sequential low-level image processing
      steps. In WMH detection, the potential WMH clusters were detected using an
      intensity based threshold and region growing approach. For false positive
      reduction, the detected WMH clusters were classified into final WMHs and non-WMHs
      using the random forest (RF) classifier. Size, texture, and multi-scale deep
      features were used to train the RF classifier. DEWS successfully detected small
      deep WMHs with a high positive predictive value (PPV) of 0.98 and true positive
      rate (TPR) of 0.70 in the training and test sets. Similar performance of PPV
      (0.96) and TPR (0.68) was attained in the validation set. DEWS showed a superior
      performance in comparison with other methods. Our proposed pipeline is freely
      available online to help the research community in quantifying deep WMHs in non
      elderly adults.

PMID- 29845014
TI  - Close relationship of Plasmodium sequences detected from South American pampas
      deer (Ozotoceros bezoarticus) to Plasmodium spp. in North American white-tailed
      deer.
AB  - We report, for the first time, the presence of ungulate malaria parasites in
      South America. We conducted PCR-based surveys of blood samples of multiple deer
      species and water buffalo from Brazil and detected Plasmodium sequences from
      pampas deer (Ozotoceros bezoarticus) samples. Phylogenic analysis revealed that
      the obtained sequences are closely related to the Plasmodium odocoilei clade 2
      sequence from North American white-tailed deer (Odocoileus virginianus).
      Nucleotide differences suggest that malaria parasites in South American pampas
      deer and North American P. odocoilei clade 2 branched more recently than the
      Great American Interchange.

PMID- 29845013
TI  - The anatomy of the human medial forebrain bundle: Ventral tegmental area
      connections to reward-associated subcortical and frontal lobe regions.
AB  - Introduction: Despite their importance in reward, motivation, and learning there
      is only sparse anatomical knowledge about the human medial forebrain bundle (MFB)
      and the connectivity of the ventral tegmental area (VTA). A thorough anatomical
      and microstructural description of the reward related PFC/OFC regions and their
      connection to the VTA - the superolateral branch of the MFB (slMFB) - is however
      mandatory to enable an interpretation of distinct therapeutic effects from
      different interventional treatment modalities in neuropsychiatric disorders (DBS,
      TMS etc.). This work aims at a normative description of the human MFB (and more
      detailed the slMFB) anatomy with respect to distant prefrontal connections and
      microstructural features. Methods and material: Healthy subjects (n = 55; mean
      age +/- SD, 40 +/- 10 years; 32 females) underwent high resolution anatomical
      magnetic resonance imaging including diffusion tensor imaging. Connectivity of
      the VTA and the resulting slMFB were investigated on the group level using a
      global tractography approach. The Desikan/Killiany parceling (8 segments) of the
      prefrontal cortex was used to describe sub-segments of the MFB. A qualitative
      overlap with Brodmann areas was additionally described. Additionally, a pure
      visual analysis was performed comparing local and global tracking approaches for
      their ability to fully visualize the slMFB. Results: The MFB could be robustly
      described both in the present sample as well as in additional control analyses in
      data from the human connectome project. Most VTA- connections reached the
      superior frontal gyrus, the middel frontal gyrus and the lateral orbitofrontal
      region corresponding to Brodmann areas 10, 9, 8, 11, and 11m. The projections to
      these regions comprised 97% (right) and 98% (left) of the total relative fiber
      counts of the slMFB. Discussion: The anatomical description of the human MFB
      shows far reaching connectivity of VTA to reward-related subcortical and cortical
      prefrontal regions - but not to emotion-related regions on the medial cortical
      surface - realized via the superolateral branch of the MFB. Local tractography
      approaches appear to be inferior in showing these far-reaching projections. Since
      these local approaches are typically used for surgical targeting of DBS
      procedures, the here established detailed map might - as a normative template -
      guide future efforts to target deep brain stimulation of the slMFB in depression
      and other disorders related to dysfunction of reward and reward-associated
      learning.

PMID- 29845015
TI  - Risks of long-term port use in enzyme replacement therapy for lysosomal storage
      disorders.
AB  - Totally implantable vascular access devices (TIVADs) are commonly used in
      conjunction with enzyme replacement therapy (ERT) for lysosomal storage disorders
      (LSDs). This case series describes potential complications associated with long
      term TIVAD use, such as compromise of skin integrity, infection, or port
      failures. Best practices and skilled specialists are essential for minimizing
      complications from long-term TIVAD use for ERT.

PMID- 29845016
TI  - Spinal Anesthesia in an Infant with Osteogenesis Imperfecta.

PMID- 29845017
TI  - Incidence and Mortality of Various Cancers in Iran and Compare to Other
      Countries: A Review Article.
AB  - Background: Iran in recent years had the rapid development of industrialization
      and modernity, and changes in the people's lifestyles and environment, these
      changes may affect epidemiological patterns of various types of cancers. In this
      review, incidence and mortality of various cancers (skin, gastric, esophageal,
      breast, and prostate) in Iran have been reported. Methods: The related data about
      Iran and other countries were collected from databases such as Google Scholar,
      Scopus, PubMed, EMBASE, and Web of Science. All included studies were published
      before Jun 2017. Results: There is an increment trend of incidence and mortality
      rate for most cancers in Iran. Conclusion: The plan for control and prevention of
      cancers must be a high priority for health policy in Iran as well as it is
      suggested that earlier screening is need for high-risk population.

PMID- 29845018
TI  - Prevalence of Drug-resistant Klebsiella pneumoniae in Iran: A Review Article.
AB  - Background: The infections caused by drug resistant strains of Klebsiella
      pneumoniae are becoming an important health problem worldwide. There are several
      reports on antimicrobial resistant status of K. pneumoniae in Iran. However, a
      comprehensive analysis on drug-resistant K. pneumoniae from different parts of
      Iran has not yet been performed. Methods: The searches were done according to
      several English and Persian databases including PubMed, Scopus, Iranmedex, and
      SID to identify studies addressing antibiotic resistant K. pneumoniae in Iran
      from Jan 1998 to Nov 2014. Comprehensive Meta-Analysis (V2.2, Biostat) software
      was used to analyze the data. Results: The incidence rate of imipenem and
      ceftazidime resistance in K. pneumoniae isolates was 3.2% (95% confidence
      interval [CI], 1.5-6.5) and 55.7% (95% CI, 46.9-64.1), respectively. The highest
      rate of resistance in isolates of K. pneumoniae was seen against ampicillin
      (82.2%), aztreonam (55.4%) and nitrofurantoin (54.5%). Conclusion: There is a
      relatively high prevalence of drug resistant K. pneumoniae isolates in Iran.
      Thus, a high degree of awareness among physicians and microbiologists, active
      infection control committee, appropriate antimicrobial therapy, improvement of
      hygiene condition and monitoring of drug resistant isolates are urgently needed
      in order to better control the emergence and spread of drug-resistant K.
      pneumoniae isolates in hospital settings.

PMID- 29845019
TI  - Sarcopenia Is Associated with Cognitive Impairment and Depression in Elderly
      Korean Women.
AB  - Background: Sarcopenia has been implicated in the increased risk for cognitive
      impairment and depression associated with aging. In this cross-sectional study,
      we investigated the relationship of sarcopenia with cognitive impairment (MCI)
      and depression in a sample of 201 community-dwelling Korean women (mean age of
      74.0+/-6.8 yr) between 2014 and 2015. Methods: The Korean version of mini-mental
      state examination and the center for epidemiologic studies depression scale was
      used to assess cognitive performance and depression, respectively. Grp strength
      was measured with a dynamometer. Demographics, body composition, education,
      alcohol consumption, and history of cardiovascular diseases were assessed as
      covariates. Results: Odds ratio (OR) and 95% confidence interval (95% CI) of MCI
      and depression were calculated according to sarcopenia status. Compared to non
      sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 2.160 (95% CI of
      0.840 - 5.554, P=0.030) and of 5.493 (95% CI of 1.854 - 16.270, P=0.002) for MCI.
      The OR of pre-sarcopenia for MCI remained significant (P=0.030) even after
      adjustments for age, body mass index (BMI), lean body mass, and education, while
      the OR of sarcopenia for MCI was no longer significant (P=0.084) when adjusted
      for the covariates. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic
      women had the ORs of 3.750 (95% CI of 1.137 - 12.370, P=0.030) and of 4.687 (95%
      CI of 1.127-19.505, P=0.034) for depression. The ORs of pre-sarcopenia and
      sarcopenia for depression remained statistically significant (P=0.020 and
      P=0.042, respectively) even after adjusted for the covariates. Conclusion:
      Sarcopenia was significantly associated with MCI and depression in otherwise
      healthy community dwelling elderly Korean women.

PMID- 29845020
TI  - Investigation of the Effects of Antibiotic Application on the Intestinal Flora in
      Elderly Hypertension Patients with Infectious Diseases.
AB  - Background: This study aimed to investigate the effects of antibiotic application
      on the intestinal flora in elderly hypertension patients with infectious
      diseases. Methods: A total of 2350 infected patients treated in Ordos Central
      Hospital (Inner Mongolia, China) from January 2010 to August 2016 were
      retrospectively analyzed and 790 healthy hypertension patients were selected as
      the control group. The 2350 patients were assigned into group A and B based on
      the administration with narrow-spectrum antibiotic or broad-spectrum antibiotic.
      The feces specimens of patients at the 1st, 5th, 9th and 14th day after
      antibiotic treatment were collected to analyze the bacteriological data and the
      cases of intestinal flora imbalance after applying the narrow-spectrum and broad
      spectrum antibiotic were compared and the differences in the bacterial colony
      compositions of intestinal floras from those of the healthy hypertension patients
      at the same period were analyzed. Results: The ratio of intestinal flora
      imbalance was 50.4% after applying antibiotic in patients from group A and 78.3%
      in group B. grade I and II imbalance were predominant in group A and grade III
      imbalance was the most severe one in group B (P<0.05). Compared with the
      intestinal flora in healthy elderly hypertension patients, the ratio of the
      primary composition flora of patients with imbalanced intestinal flora was
      changed obviously. Conclusion: The application of narrow-spectrum antibiotic and
      shortening the application time of antibiotic can more effectively protect the
      normal intestinal flora of elderly hypertension patients.

PMID- 29845021
TI  - Smartphone Addiction and Interpersonal Competence of Nursing Students.
AB  - Background: Interpersonal competence is an important capacity for nurses.
      Recently, the advent of smartphones has instigated considerable changes in daily
      life. Because smartphone has multiple functions, people tend to use them for
      numerous activities, often leading to addictive behavior. Methods: This cross
      sectional study performed a detailed analysis of smartphone addiction subscales
      and social support related to interpersonal competence of nursing students.
      Overall, 324 college students were recruited at Catholic University in Seoul,
      Korea from Feb 2013 to Mar 2013. Participants completed a self-reported
      questionnaire, which included scales that measured smartphone addiction, social
      support, interpersonal competence, and general characteristics. Path analysis was
      used to evaluate structural relations between subscales of smartphone addictions,
      social support, and interpersonal competence. Results: The effect of cyberspace
      oriented relationships and social support on interpersonal competence were 1.360
      (P=.004) and 0.555 (P<.001), respectively. Conclusion: Cyberspace-oriented
      relationship, which is a smartphone addiction subscale, and social support were
      positively correlated with interpersonal competence of nursing students, while
      other smartphone addiction subscales were not related to nursing student
      interpersonal competence. Therefore, effective smartphone teaching methods be
      developed to enhance nursing student motivation.

PMID- 29845022
TI  - Hypermethylation of DcR1 Gene-based Biomarker in Non-invasive Cancer Screening of
      Vietnamese Cervical Cancer Patients.
AB  - Background: The infection of human papillomavirus (HPV) has been considered as
      the common cause of cervical cancer, which is the leading cause of cancer death
      in women, in Vietnam. Recently, hypermethylation at tumor suppressor genes (TSGs)
      has been also demonstrated to be an early epigenetic event and cofactor in human
      cancer, including cancer of cervix. This study evaluated the frequency of DcR1
      gene promoter hyper-methylation status as well as whether did or not an
      association between patterns of DNA hypermethylation and high-risk HPV infection,
      led to risk of cervical cancer. Methods: Methylation-Specific-PCR (MSP) was
      performed to analyze hypermethylation status from 109 liquid-based Papanicolaou
      test samples, archived and admitted from the Medic Medical Center and Au Lac
      Clinic Laboratory, Vietnam, from 2011-2014, a kind of non-invasive samples
      identified whether HPV/or non-HPV, high-risk/low-risk HPV infection. Results:
      DcR1 promoter was differentially methylated in 50% cases of high-risk HPV
      genotype 16 and 18 infected samples. In contrast, a low frequency of
      hypermethylated DcR1 promoter was found in low risk HPV genotype infected sample
      (16.0%), and non-HPV infected sample (14.6%). A trend toward positive association
      was found between hypermethylation of DcR1 gene and HPV exposure was observed
      (P=0.0005). Moreover, the odds ratio (OR) and relative risk (RR) were found in
      statistical significant value (OR=5.63 (95%CI = 2.25 - 14.07, P<0.01), RR=3.31
      (95%CI = 1.75 - 6.26, P<0.01)). Conclusion: The hypermethylation of DcR1 gene
      promoter is a significant characteristic of high-risk HPV infected samples in
      Vietnamese cervical patients. The OR and RR values showed that the strong
      correlation between DcR1 hypermethylation and high-risk HPV infection, in which
      increased the risk of cervical cancer. The combination of DcR1 hypermethylation
      and HPV detection based biomarker could be used in noninvasive samples obtained
      from high-risk cancer patients, offer significant practical advantages.

PMID- 29845023
TI  - Victimization of the Substance Abuse and Sexual Behaviors among Junior High
      School Students in Cambodia.
AB  - Background: We examined the current prevalence of substance abuse and sexual
      behaviors among junior high school students and the relationships between
      substance abuse, sexual behaviors, and victimization using multiple mediations.
      Methods: Overall, 1703 junior high school students from the 2013 Cambodia Global
      School-based Health Survey were selected for the study. The descriptive
      statistics were performed in IBM SPSS to determine the prevalence of substance
      abuse, sexual behaviors, and victimization. The Process Macro was installed in
      Regression of the SPSS to test the hypotheses and mediations. Results: The
      majority of students who used alcohol (15.4%), drugs (3.05%), and had sexual
      intercourse (12.45%), were male aged 14-15, and in grade 7. These students were
      very vulnerable to many risky behaviors, including bullying (22.20%), physical
      attacks (20.96%) and fights (14.50%), unintentional accidents (21.32%), and
      suicidal attempts (5.05%). All three hypotheses were significantly supported. Of
      the potential mediators examined, drug use is the most important mediator.
      Conclusion: The substance abuse and reproductive health are national problems,
      but abusive behaviors among students are of particular concern. Explicit policies
      and awareness programs of such problems at the high school level need to be made
      and called for public participation, particularly the school authorities and
      parents.

PMID- 29845024
TI  - Diagnostic Value of Urinary Microalbumin Level in Postpartum Acute Kidney Injury.
AB  - Background: We aimed to explore the diagnostic value of urinary microalbumin
      (mALB) level in postpartum acute kidney injury. Methods: A total of 127 maternity
      patients were selected from December 2013 to January in 2016 in Binzhou Central
      Hospital, Binzhou, Shandong, China and divided into two groups: the kidney injury
      and normal kidney group. The dynamic changes and diagnostic value of urine
      microprotein in postpartum acute kidney injury were analyzed. Results: The
      postpartum mean arterial pressure of maternity patients in the kidney injury
      group was 104.3 +/- 11.6 mmHg, which was significantly higher than that of the
      normal kidney group (P<0.05). The mean age of the kidney injury group was 32.3 +/
      11.6 years, which was significantly higher than that of the normal kidney group
      (P=0.006). In the kidney injury group, the postpartum glomerular filtration rate
      (GFR) was 78.4 +/- 11.5 mL/min, which was significantly lower than the normal
      group (P=0.001), and urinary microalbumin was 2.87 +/- 1.24 mg/mmol.Cr. The
      difference was statistically significant (P=0.002). mALB/GFR, Cr, urinary mALB,
      and GFR were the independent risk factors of postpartum acute kidney injury. The
      area under the ROC curve for mALB/GFR was 0.759, whereas the area under the ROC
      curve for Cr was 0.681, which was smaller (P = 0.042). The area under the ROC
      curve of mALB was 0.785 (P=0.027), which was close to the area under the ROC
      curve of mALB/GFR. Conclusion: Urinary mALB test is noninvasive and has high
      diagnostic value for postpartum kidney injury.

PMID- 29845025
TI  - Effects of Different Spectral Energy Distributions on Physiological Behavior and
      Hormone Levels in Depression.
AB  - Background: The increasing worldwide incidence of depression causes massive
      economic losses to the country and society. Insufficient sun exposure aggravates
      depressive symptoms in patients with depression. Preventive light replenishment
      is provided to patients with depression and the potential population. In
      addition, we studied the applicable spectrum, which is crucial in the prevention
      of depression. Methods: Forty depressed male rats were randomly divided into five
      groups of 8 rats each: depressive model, microwave sulfur lamp, halogen lamp,
      fluorescent lamp, and LED lamp groups. Rats in the illuminated groups were
      exposed to light for 45 days for 2 h daily. Eight healthy rats were selected for
      the control group. The body weight and general behaviors of rats were recorded.
      After the experiment, peripheral blood was collected from the tail vein, and the
      concentrations of MT, 5-HT, NA, and BDNF in serum were detected by ELISA.
      Results: After the model was established, the body weight of rats in the
      depressive model group increased slowly. Compared with those of the control
      group, the results of the three behavioral tests were significantly different
      (P<0.05); the contents of MT, 5-HT, NA, and BDNF were relatively low (P<0.05). In
      addition, depression characteristics were significant. Rats regained their
      pleasant sensation after microwave sulfur lamp intervention. Compared with the
      rats in the depressive model group, the levels of MT, 5-HT, NA, and BDNF
      increased sharply. Conclusion: The spectral energy distribution of microwave
      sulfur lamp is similar to the solar spectrum, which can alleviate depressive
      symptoms in depressed rats.

PMID- 29845027
TI  - Iran's Health Reform Plan: Measuring Changes in Equity Indices.
AB  - Background: Two years after the implementation of the Health Sector Evolution
      Plan (HSEP), this study evaluated the effects of the plan on health equity
      indices. Methods: The main indices assessed by the study were the Out-of-Pocket
      (OOP) health expenditures, the Fairness in Financial Contribution (FFC) to the
      health system index, the index of households' Catastrophic Health Expenditure
      (CHE) and the headcount ratio of Impoverishing Health Expenditure (IHE). Results:
      The per capita share of costs for total health services has been decreased. The
      lowered costs have been more felt in rural areas, generally due to sharp decrease
      in inpatient costs. Per capita pay for outpatient services is almost constant or
      has slightly increased. The reform plan has managed to improve households'
      Catastrophic Health Expenditure (CHE) index from an average of 2.9% before the
      implementation of the plan to 2.3% after the plan. The Fairness in Financial
      Contribution (FFC) to the health system index has worsened from 0.79 to 0.76, and
      the headcount ratio of Impoverishing Health Expenditure (IHE) index deteriorated
      after the implementation of plan from 0.34 to 0.50. Conclusion: Considerable
      improvement, in decreasing the burden of catastrophic hospital costs in low
      income strata which is about 26% relative to the time before the implementation
      of the plan can be regarded as the main achievement of the plan, whereas the
      worsening in the headcount ratio of IHE and FFC are the equity bottlenecks of the
      plan.

PMID- 29845026
TI  - Effect of Soy Isoflavone on Hot Flushes, Endometrial Thickness, and Breast
      Clinical as well as Sonographic Features.
AB  - Background: Phytoestrogens treatment to relieve hot flushes in menopausal women
      was considered recently. However, the actual effectiveness and safety are not
      clear. Methods: Randomized clinical trial (IRCT#20100706004329N5) was performed
      in 204 patients who complained of hot flushes in Arash Women's Hospital, Tehran,
      Iran from 2013-2015. The first group received 50 mg isoflavone (group A) once
      daily and the second group received placebo (group B) in the same regimen.
      Patients were evaluated for breast examination (BE) and breast sonography (BS) as
      well as vaginal sonography at initial presentation and at 6th and 12th week
      follow-ups. Patients were educated to record frequency and severity of hot
      flushes. Results: Group A experienced less hot flushes attack (6 vs 9 patients
      with 5< attacks in 6 wk (P= 0.05), 7 Vs 13 patients with 5< in 12 wk (P=0.01))
      which was also less severe (8 vs 12 patients with severe symptoms in 6 wk (0.04)
      and 3 Vs 10 patients with severe symptoms in 12 wk (0.001). Isoflavone had no
      effect on neither breast density nor nodularity (in 6 wk, P=0.50 and 0.80,
      respectively and in 12 wk, P=0.32 and 0.43) and neither breast tenderness nor
      nipple discharge (in 6 wk, P=0.40 and 0.34 respectively and in 12 wk, P= 0.31 and
      0.26). There were no significant differences in endometrial thickness in 6 and
      12wk. Conclusion: Effects of isoflavone on frequency and severity of hot flushes
      in perimenopausal women is observed. Some clinical and ultrasonographic benign
      non-significant changes of the breast and endometrium are noted after isoflavone
      intake.

PMID- 29845029
TI  - Cost-utility of Protocols of BFM-ALL and UK-ALL for Treatment of Children with
      Acute Lymphoblastic Leukemia in Iran.
AB  - Background: There is a requirement to assess the effectiveness and resources used
      in two protocols United Kingdom (UK-ALL) and Berlin-Frankfurt-Munster (BFM-ALL)
      that are most commonly used to treatment of ALL patients by oncologists in Iran.
      Accordingly, we analyzed the cost of treatment and utility of children treated
      with two protocols in Iran. Methods: The entire medical direct costs of patients
      in "BFM ALL" protocol and "UK ALL" protocol in multi-centers calculated from Apr
      2010 to Jun 2015. For calculating utility and Quality Adjusted Life Year (QALY)
      of the patients, we used standard questionnaire Health Utilities Index 3 (HUI3).
      The patients and their parents were interviewed. Data were analyzed using
      software SPSS18 and EXCEL. Results: The average direct medical cost for each
      patient for BFM-ALL was 15026 USD and UK-ALL was 8282 USD which showed a
      significant difference in the total cost of the treatment in the two protocols
      (P<=0.02). Finally, there was a significant difference in the utility score of
      the maintenance phase of these two methods (P<=0.003). Conclusion: UK-ALL is
      dominant and BFM protocol is dominated by both sides total costs and utility and
      QALY. Mainly, more hospital stay in "BFM ALL" protocol is the cause of raised
      costs in this protocol. Consequently, by considering different QALYs in the
      methods and low costs in "UK ALL" protocol, "UK ALL" protocol is more preferred.

PMID- 29845028
TI  - NF-kappaB1 Rs28362491 Mutant Allele Frequencies along the Silk Road and Beyond.
AB  - Background: In the human evolutionary history, Single Nucleotide Polymorphism
      (SNP) frequencies are valuable in terms of finding connections between different
      populations. Due to the pronounced role of the immune system in combating
      pathogens and environmental stressors, polymorphisms in the immune genes are
      subject to selection pressure of the diseases as well. The functional
      polymorphisms in NF-kappaB1 promoter (-94 ins/del) are associated with different
      diseases; therefore, we aimed to establish the frequencies of NF-kappaB1
      rs28362491 alleles in a population of Southwestern Iranians in comparison with
      the world populations. Methods: We assessed the polymorphism of -94 ATTG ins/del
      (rs28362491) in 201 Iranian healthy blood donors from Fars Province, central Iran
      in a one year period between 2015 and 2016 by PCR-RFLP method using DNA extracted
      from peripheral blood mononuclear cells. Results: The frequency of ins/ins
      homozygote genotype was found to be 46.97%. The frequency of heterozygote
      individuals was 42.42% and the percentage of del/del homozygote genotype was
      10.61%. We observed a genetic similarity based on the genotype frequencies of NF
      kappaB1 -94 ins/del ATTG polymorphism between our sample of Iranians with
      American Jewish, Turkish, American non-Jewish, Chinese-Uyghurs and Germans.
      Conclusion: The results confirmed genetic interrelation of Iranians with some
      ancient neighbors and their admixture with countries along the Silk Road. We
      suggest that mapping the distribution of NF-kappaB1-94 ATTG ins/del along with
      HLA genes may help to better define the relations between human populations and
      design population-specific vaccines for pathogens with a high rate of variation.

PMID- 29845030
TI  - Birth Defects in Northern Iran (2008-2013).
AB  - Background: Congenital anomalies are important medical and public health
      conditions. The pattern and prevalence of birth defects may vary over time or
      with geographical location. We investigated the live birth prevalence and
      occurrence pattern of birth defects in Golestan Province, northern Iran. Methods:
      This cross-sectional descriptive study was carried out on 144920 live newborns in
      13 hospitals in Golestan Province, northern Iran, from 21 Jan 2008 to 19 Mar
      2013. The newborns were examined for the presence of birth defects and mothers
      were interviewed for variables such as maternal age and ethnicity. In addition,
      data for each newborn was filed in a questionnaire and the coding of birth
      defects was translated to the International Classification of Diseases 10th
      revision-clinical modification (ICD-10-CM). Results: Overall, 1690 infants were
      diagnosed as having birth defects among 144920 live newborns. The prevalence rate
      of birth defects was 11.66 per 1000 live births, the prevalence of birth defects
      per 1000 was11.62 in males and 11.42 in females. The prevalence of congenital
      anomalies among native Fars, Turkmen and Sistani were 13.03, 11.16 and 13.07,
      respectively, per 1000 live births. Anomalies of the cardiovascular system were
      the most common defects; the prevalence rate of cardiovascular system was 8.34
      per 1000 live birth. Conclusion: The prevalence rate of birth defects in this
      area was lower than in the other regions in Iran (20.3 per 1000 live births) but
      higher than in some parts of Asia (7.33 per 1000 live births).

PMID- 29845031
TI  - Effective Factors on the Rate of Growth Failure in Children below Two Years of
      Age: A Recurrent Events Model.
AB  - Background: Growth failure, constituting one the health problems in children
      below 2 yr of age, can lead to major complications such as death or mental,
      emotional and physical disabilities. The present study aimed to investigate
      effective factors on growth failure in the height and weight of less than 2 yr
      old children of Khorramabad, Iran in 2013. Methods: This present longitudinal
      retrospective study used stratified and clustered sampling. Based on growth
      curves in family records, the incidence times of growth failure in height and
      weight of each child were recorded. In the next stage, using recurrent events
      model (proportional rate model), along with SAS software (version 9.2), the data
      were modeled. Results: According to proportional rate model, the effect of
      mothers' educational level on the rate of growth failure in the height and weight
      of children was significant (P=0.046, P=0.049) and the effect of fathers' job was
      significant only on growth failure in children's weight (P<0.001). However, the
      effect of other variables, including gender, birth order and exclusive
      breastfeeding status on children's growth failure rate was not significant.
      Conclusion: Enhancing mother's awareness in low-income families, in tandem with
      changing educated mothers' attitude towards the required skills and guiding
      principles for feeding children below 2 yr of age, can be conceived of as the
      most important approach in dealing with growth failure of children.

PMID- 29845032
TI  - Socioeconomic Inequalities in Different Types of Disabilities in Iran.
AB  - Background: This study measured socioeconomic inequalities in different types of
      disabilities in Iran. We also examined the prevalence of disabilities across
      different socio-demographic groups in Iran in 2011. Methods: This was cross
      sectional study using secondary data analysis on all Iranian. Data related to
      disability prevalence and socioeconomic status (SES) of each province was
      extracted from the 2011 National Census of Population and Housing (NCPH) and the
      2011 Households Income and Expenditure Survey (HIES), conducted by Statistical
      Center of Iran (SCI). The concentration index and concentration curve were used
      to measure and illustrate socioeconomic inequalities in different types of
      disabilities. Chi-squared test was also used to examine the relationship between
      the socio-demographic variables (age-groups, sex, education level, employment
      status) and disability. Results: The results suggested the existence of
      socioeconomic inequalities in blindness, deafness, vocal disorders and hand
      disorders in Iran. The concentration index for these four disabilities were 
      0.0527 (95% confidence interval [CI]: -0.0881, -0.0173), -0.0451 (CI: -0.0747, 
      0.0156), -0.0663 (CI: -0.1043, -0.0282) and -0.0545 (CI: -0.0940, -0.0151),
      respectively. There were also significant associations between the demographic
      variables such as age-groups, sex, education level, employment status and
      disability (P<0.05). Conclusion: There were significant socioeconomic
      inequalities in different types of disabilities in Iran with poorer provinces
      having higher prevalence of disabilities in blindness, deafness, vocal disorders
      and hand disorders. Strategies to address the higher prevalence of different
      types of disabilities among poorer provinces should be considered a priority in
      Iran.

PMID- 29845033
TI  - Y-chromosomal Status of Six Indo-European-speaking Arab Subpopulations in
      Chaharmahal and Bakhtiari Province, Iran.
AB  - Background: We analyzed the Y-chromosome haplogroups of six documented Arab
      subpopulations that accommodated separately in different counties of Chaharmahal
      and Bakhtiari Province but nowadays speak Indo-European language (Luri and
      Farsi). Methods: This was an outcome study conducted in 2015 to test whether
      there was any genetic relatedness among some Indo-European-speaking Arab
      subpopulation accommodated in a geographically similar region, Chaharmahal and
      Bakhtiari Province, Iran. Seven main Y-chromosome bi-allelic markers were
      genotyped in six documented Arab subpopulations. Therefore, after DNA extraction
      from blood samples, PCR reaction carried out by designed primers for J1-M267, J2
      M172, and J-M304, I-M170, IJ-M429, F-M89 and K-M9 markers. Then PCR products
      after quality control on agarose gel were sequenced. Results: Most subjects
      (83.3%) belonged to F-M89 haplogroup. These subjects belonged to K-M9 (40%), J2
      M172 (40%) and I-M170 (20%). Generally, there were at least three genetically
      distinct ancestors with a divergence date of about 22200 yr for I, 429000 for J
      and 47400 before present for K haplogroup and may show separate historical
      migrations of studied populations. As the most recent common ancestor (MRCA) of
      most of these populations, haplogroup F, lived about 40000-50000 yr ago, the data
      do not support a nearly close genetic relationship among all of these
      populations. However, there were populations with same haplogroups J2 (n=2), K
      (n=2), or with a closer MRCA, IJ haplogroups, among I and J2 haplogroups. Finding
      haplogroup I, a specific European haplogroup, among Arab populations was not
      expected. Conclusion: Identification of various haplogroups in Arab
      subpopulations despite its small area and geographically conserved region of this
      part of Iranian plateau was unexpected.

PMID- 29845034
TI  - A Population-based Prospective Study to Identify Contributors to Mother and Child
      Health in Suburban Communities: The Cohort Profile.
AB  - Background: Following community health assessment Project (CHAP) in suburbs of
      Bandar Abbas city, health problems in women and children such as pregnancy
      complications and infant/child impaired growth are highly prevalent. Therefore,
      the present population-based prospective cohort study investigated the effects of
      a wide range of modifiable exposures during pregnancy and postpartum on mother
      and child health. Methods: The sample comprised of 1000 pregnant women in their
      first gestational trimester, who live in the three most socially and economically
      vulnerable neighborhoods of Bandar Abbas, are under recruitment during Feb 2016
      18. Four structured questionnaires are being carried out from pregnancy to 30 d,
      6 months, and 12 months postpartum. Biologic and ultrasound results are also
      gathered through hospital and health center records. The study is currently close
      to the end of the recruitment phase. Conclusion: The results of the interim and
      final analyses are being translated into applicable preventive action plans
      aiming to reduce and control modifiable risk factors for ill-health in mothers
      and children in suburb communities in South of Iran.

PMID- 29845035
TI  - Influence of Stress, Fatigue, Sleep and Delayed Onset Muscle Soreness on
      Perceived Physical Enjoyment Exertion during Small Sided Games.

PMID- 29845036
TI  - Training-induced Changes in Development and Relaxation Electromechanical Delay
      (EMD).

PMID- 29845037
TI  - Rational Drug Prescribing a Way to Reduce Patients Out of Pocket Payment.

PMID- 29845038
TI  - rs12480307 and rs6050307 Polymorphisms of VSX1 Gene in Patient with Keratoconusin
      Southwest Iran Using PCR-RFLP.

PMID- 29845039
TI  - Applying Agent-based Technologies in Complex Healthcare Environment.

PMID- 29845040
TI  - Applying Theory of Planned Behavior to Develop Family-centered Care, 2015-2016.

PMID- 29845041
TI  - Utilization of Mammography, Sonography and Radiology Services before and after
      Health Sector Evolution Plan in Iran.

PMID- 29845042
TI  - Women's Empowerment in Reproductive Decision-making Needs Attention among Iranian
      Women.

PMID- 29845043
TI  - Effects of Local Use of Insulin on Wound Healing in Non-diabetic Patients.
AB  - Background: Clinical trials have shown the positive effects of local insulin
      therapy in the formation of new vessels and fibrosis in acute and chronic
      diabetic wounds without major adverse effects. Objective: The aim of this study
      was to investigate the effects of local insulin use on wound healing in non
      diabetic patients. Methods: A randomized, split-plot, double-blind, placebo
      controlled trial was conducted. Ten non-diabetic patients with full-thickness
      acute wounds were recruited (5 due to trauma, 3 to burns, and 2 to pressure). All
      wounds received standard bedside treatment. Each wound was divided into 2 zones.
      One side received a standard care plus insulin, while the other received standard
      care plus injection of saline solution. A biopsy specimen was taken from both
      sites on days 0 and 14. The amount of blood vessel growth and the percentage of
      fibrosis were evaluated. Results: A significant difference in the number of new
      vessels was observed on the insulin-treated site (70.6 [29.21]) compared to
      saline only (26.5 [34.3]; P < .04). The percentage of fibrosis (insulin 34.7
      [28.02] vs saline 27.8 [29.9]) showed no significant difference. No adverse
      events related to the study occurred. The clinical implications of this study are
      considerable in terms of the formation of blood vessels but not fibrosis.
      Conclusion: We suggest that local insulin administration is a safe therapeutic
      option for angiogenesis in wounds of non-diabetic patients.

PMID- 29845044
TI  - Immediate Nerve Transfer for Treatment of Peroneal Nerve Palsy Secondary to an
      Intraneural Ganglion: Case Report and Review.
AB  - Intraneural ganglion cysts, which occur within the common peroneal nerve, are a
      rare cause of foot drop. The current standard of treatment for intraneural
      ganglion cysts involving the common peroneal nerve involves (1) cyst
      decompression and (2) ligation of the articular nerve branch to prevent
      recurrence. Nerve transfers are a time-dependent strategy for recovering ankle
      dorsiflexion in cases of high peroneal nerve palsy; however, this modality has
      not been performed for intraneural ganglion cysts involving the common peroneal
      nerve. We present a case of common peroneal nerve palsy secondary to an
      intraneural ganglion cyst occurring in a 74-year-old female. The patient
      presented with a 5-month history of pain in the right common peroneal nerve
      distribution and foot drop. The patient underwent simultaneous cyst
      decompression, articular nerve branch ligation, and nerve transfer of the motor
      branch to flexor hallucis longus to a motor branch of anterior tibialis muscle.
      At final follow-up, the patient demonstrated complete (M4+) return of ankle
      dorsiflexion, no pain, no evidence of recurrence and was able to bear weight
      without the need for orthotic support. Given the minimal donor site morbidity and
      recovery of ankle dorsiflexion, this report underscores the importance of
      considering early nerve transfers in cases of high peroneal neuropathy due to an
      intraneural ganglion cyst.

PMID- 29845045
TI  - Multidisciplinary Cleft Palate Program at BC Children's Hospital: Are We Meeting
      the Standards of Care?
AB  - Objective: To characterize current Cleft Palate Program (CPP) practices and
      evaluate the timeliness of appointments with respect to patient age and diagnosis
      based on American Cleft Palate-Craniofacial Association (ACPA) population
      guidelines and CPP patient-specific recommendations. Design: A retrospective
      review of CPP patient appointments from November 6, 2012, to March 31, 2015, was
      done. Data were analyzed using descriptive and inferential statistics. Setting:
      The study was conducted using data from the CPP at BC Children's Hospital.
      Patients: A total of 1214 appointments were considered in the analysis, including
      syndromic and nonsyndromic patients of 0 to 27 years of age. Main Outcome
      Measures: Percentage of patients meeting follow-up targets by ACPA standards and
      CPP team recommendations. Results: Our results showed patients 5 years and
      younger or nonsyndromic were more likely to be seen on time (P < .001). No
      relationship between the timeliness of an appointment and specific patient
      diagnoses or distance to clinic was found. With the exception of nursing (97% of
      appointments were on time), all disciplines had less than 45% of appointments on
      time with 51% of appointments meeting ACPA guidelines for timeliness and 32% of
      all appointments meeting CPP recommendations. Conclusion: Timely care for the
      cleft/craniofacial patient populations represents a challenge for the CPP.
      Although half of patients may meet the general ACPA guidelines, only 32% of
      patients are meeting the CPP patient-specific recommendations. To provide better
      patient care, future adjustments are needed, which may include improved resource
      allotment and program support.

PMID- 29845046
TI  - One Versus 2 Venous Anastomoses in Free Flap Surgery: A Systematic Review and
      Meta-Analysis.
AB  - Background: The necessity of a second venous anastomosis in free flap surgery is
      controversial. The purpose of this systematic review is to determine whether
      venous flap failure and reoperation rates are lower when 2 venous anastomoses are
      performed. The secondary objective is to determine whether venous flap failure
      and reoperation rates are lower when the 2 veins are from 2 different drainage
      systems. Methods: A comprehensive search of the literature identified relevant
      studies. Investigators independently extracted data on rates of flap failure and
      reoperation secondary to venous congestion. A meta-analysis was performed; odds
      ratios (ORs) were pooled using a random-effects model and 95% confidence
      intervals (CIs). Results: Of 18 190 studies identified, 15 were included for
      analysis. The mean sample size was 287 patients (minimum = 102, maximum = 564).
      No statistically significant difference in venous flap failure was found when
      comparing 1 versus 2 venous anastomoses (OR: 1.35; 95% CI: 0.46-3.93). A
      significant decrease in reoperation rate due to venous congestion was shown (OR:
      3.03; 95% CI: 1.64-5.58). The results favor using 2 veins from 2 different
      systems over veins from the same system (OR: 0.16; 95% CI: 0.02-1.27).
      Conclusions: There is low-quality evidence suggesting that the use of 2 venous
      anastomoses will lower the rate of reoperation due to venous congestion. There
      are insufficient data published to meaningfully compare outcomes of flaps with 2
      venous anastomoses from different systems to flaps with anastomoses from the same
      system.

PMID- 29845047
TI  - The Radiographic Quality of Distal Radius Fracture Reduction Using Sedation
      Versus Hematoma Block.
AB  - Introduction: Distal radius fractures (DRFs) are treated in the emergency
      department (ED) with a closed reduction in order to decrease neurovascular and
      soft tissue injury and as a first definitive step in conservative treatment. The
      type of anesthesia used may affect the ability to reduce the fracture and remains
      controversial. Objective: The purpose of this study was to compare the quality of
      radiographic reduction achieved in the ED of DRF reduced using sedation
      anesthesia to those reduced with hematoma block anesthesia. Methods: A
      retrospective case-control study of 240 DRF reductions, 30 treated with sedation
      and 210 with a hematoma block, was performed. Complications and time spent in the
      ED were documented. Pre- and postreduction radiographs were reviewed for volar
      tilt, radial angulation, radial height, and ulnar variance. Results: Both groups
      were similar in gender, background illnesses, concomitant injuries, surgeon
      experience, and fracture radiographic classification. Postreduction values of
      volar tilt were better in the sedation group (P = .03). Volar tilt and ulnar
      variance improved more in the sedation group (P = .001). The sedation group spent
      more time in the ED (P = .001). Discussion: Sedation seemed to be more efficient
      than hematoma block in supporting closed reduction of distal radius fractures in
      the ED. However, this method requires specialized personnel and more time spent
      in the ED. Conclusion: We suggest using this method when the patient is planned
      to continue with conservative treatment.

PMID- 29845048
TI  - Undergraduate Plastic Surgery Education: A National Survey of Clerkship
      Directors.
AB  - Background: The delivery of medical education has received increased attention in
      recent years due to ongoing time and financial constraints faced by medical
      educators. Given the recent calls to action by the Carnegie Foundation and Health
      Canada, an evaluation of the specialty education sector is warranted. To our
      knowledge, this is the first assessment of the Canadian plastic surgery
      undergraduate clerkship curriculum. Method: An anonymous electronic survey was
      distributed to the plastic surgery clerkship directors of all Canadian medical
      schools (N = 17). The survey consisted of Likert scales and open-ended short
      answer questions. Themes included general clerkship information, exposure
      characteristics, teaching characteristics, resource characteristics, and
      challenges and barriers faced by clerkship directors. Results: Survey response
      rate was 88%. All responding schools offered a clerkship rotation of varying
      length in time (1-4 weeks). Students had the most exposure to breast surgery
      (100%) and general plastic surgery (100%) and the least exposure to aesthetic
      surgery (40%). Sixty percent of schools indicated the use of modern educational
      methods. Resources available for teaching students varied. Rotations received
      excellent feedback from medical students (67%). More than half of respondents
      would like to see a universal, nationally formulated plastic surgery clerkship
      curriculum. Conclusion: There is significant heterogeneity in the delivery of
      plastic surgery clerkship in Canada. A number of areas for improvement have been
      identified. We hope to establish a national plastic surgery clerkship task force
      to address the concerns raised here and improve the delivery of undergraduate
      medical education. Assessment of students based on a national curriculum may help
      in decision-making regarding plastic surgery program admissions by introducing an
      element of standardization to clerkship exposure.

PMID- 29845049
TI  - Antibiotic Irrigation of Pocket for Implant-Based Breast Augmentation to Prevent
      Capsular Contracture: A Systematic Review.
AB  - Background: In vitro and in vivo studies have described a number of different
      antibiotic solutions for irrigation of the pocket in implant-based breast
      augmentation in an attempt to prevent the formation of capsular contracture (CC).
      Our objective was to evaluate the evidence that antibiotic irrigation reduced the
      rate of CC. Methods: A systematic search of MEDLINE, EMBASE, and CENTRAL was
      conducted from inception to January 2016. We included studies which examined the
      use of intraoperative antibiotic irrigation in women undergoing primary breast
      augmentation. Our primary outcome was the rate of CC. Included studies were
      assessed for methodological quality using validated tools. Results: Seven studies
      were included in the final analysis: 1 randomized controlled trial (RCT) and 6
      non-randomized studies. The mean follow-up ranged from 14 to 72 months. The rate
      of CC was less than 2% in 8 studies, between 3% and 6% in 4 studies, and 13.9% in
      1 study. Included studies demonstrated significant clinical and methodological
      heterogeneity. The solitary low-quality RCT concluded that antibiotic irrigation
      was superior to saline irrigation. Three non-randomized studies demonstrated no
      significant difference in the rate of CC with the use of antibiotics. One non
      randomized controlled study showed that the use of mixture of antibiotic and
      povidone-iodine significantly lowered the rate of CC. Conclusions: The available
      evidence on the use of antibiotic irrigation to prevent CC is weak and it is
      based on studies with high risk of bias. Methodologically robust studies are
      necessary to answer the question whether antibiotic breast pocket irrigation
      prevents CC.

PMID- 29845050
TI  - Innervation of the Flexor Digitorum Profundus: A Systematic Review.
AB  - Purpose: The aim of this study was to review the innervation of the flexor
      digitorum profundus (FDP). Methods: In PubMed and Scopus, terms (Flexor digitorum
      profundus OR FDP) AND (innervation OR nerve) were used, resulting in 233 and 281
      papers, respectively. After excluding 142 duplicates, 73 abstracts were reviewed.
      Forty-seven abstracts were excluded, 26 full papers were reviewed, and 17 papers
      were analyzed. Results: In most cases (97.6%), the index FDP was innervated by
      the anterior interosseous nerve (AIN). Dual innervation from the AIN and ulnar
      nerve (UN) was observed in 2.4% of papers. In majority (76.8%), the middle FDP
      received dual innervation from the AIN and the UN. The rest was innervated by the
      AIN only (22.0%) or the UN only (1.2%). In most cases (85.4%), the ring FDP was
      innervated by the UN only. The rest (14.6%) received dual innervation from the
      AIN and the UN. In majority of cases (64.6%), the little FDP was innervated by
      the UN only. The rest (35.4%) received dual innervation from the AIN and the UN.
      The AIN entered the FDP at 107.63 (8.80) mm from the elbow, corresponding to
      26.75% (2.17%) of the forearm length, measured proximally. The average number of
      AIN branches to the FDP was 2.27 (1.33). The average number of UN branches to the
      FDP was 1.37 (0.94). In 8.8% of limbs, a communicating branch supplied the FDP.
      Among the limbs with a communicating branch, 32.3% had branches supplying the
      FDP. Conclusion: The results of this study may be useful in managing nerve injury
      patients.

PMID- 29845052
TI  - Oral Exam.

PMID- 29845051
TI  - Laparoscopic Harvesting of Omental Flaps for Breast Reconstruction-A Review of
      the Literature and Outcome Analysis.
AB  - Background: Evidence on the use of omental flaps for breast reconstruction in
      patients with breast cancer is lacking, and no published reviews report an
      outcome-based assessment of such flap. This review explores available data and
      evidence for change in complication rates following the shift toward laparoscopic
      harvesting. Methods: We searched the databases Excerpta Medica database, MEDLINE,
      and PubMed from inception until December 2015 using search terms "omental flaps"
      and "breast reconstruction." Data extracted were patient characteristics,
      technique used, and outcome measures reported and were then analyzed based on the
      technique of harvesting. Results: Twenty-two articles reporting 651 patients who
      underwent mastectomies and breast-conserving surgeries were included in this
      review. Most flaps, 537 (82.5%), were harvested by laparoscopy, and 626 (96.2%)
      of the flaps were pedicle flaps. The mean age was 47.7 years (standard deviation:
      4.29), and mean follow-up was 38.1 months. There were 88 reported complications
      among 562 patients in 16 reports. The rate of any complication was calculated to
      be 15.0%, with a higher rate (29.1%) occurring with the open technique in
      comparison to laparoscopy (12.6%). The commonest complications were postoperative
      infection and breast firmness each reported in 2.22%. Most authors reported
      advantages of malleability and excellent aesthetic outcomes and disadvantages in
      terms of inability to estimate the volume of the flap and variability in size.
      Conclusion: Omentum use is safe and has advantages in breast reconstruction where
      other options are limited including a natural feeling and minimal donor site
      morbidity if harvested laparoscopically.

PMID- 29845053
TI  - Digital Gold: A Primer on Cryptocurrency.

PMID- 29845054
TI  - Targeting Colorectal Cancer Cell Lines Using Nanobodies; AgSK1as a Potential
      Target.
AB  - Background: Colorectal cancer is the third most common type of aggressive
      cancers. Chemotherapy, surgery, and radiotherapy are the common therapeutic
      options for treating this cancer. Due to the adverse side-effects of these
      methods, immunotherapy is considered as an appropriate alternative therapeutic
      option. Treatment through the application of monoclonal antibodies is considered
      as a novel alternative therapeutic method for cancers. The variable fragments of
      the antibodies' heavy chain or VHHs have a wide application in molecular biology
      and biotechnology. VHHs are compatible with the phage display technology which
      allows rapid and high throughput screening for antibodies isolation. Objectives:
      We aimed to use naive VHH phage library to isolate a specific nanobody against
      colorectal tumor associated antigen; the AgSK1. Materials and Methods: In this
      research, naive VHH phage library was panned against two colorectal cell lines;
      Ls174T and HT29 expressing different levels of AgSK1 tumor associated marker. The
      high affinity binders were selected and subcloned for higher expression levels of
      the VHH. The affinity and specificity of the isolated VHH were tested using
      ELISA. The reactivity of the VHH toward cancer cells was analyzed by competitive
      ELISA applying sera isolated from colorectal cancer patients. Results: Results
      show that the isolated VHH recognizes and binds to the colorectal cancer cells
      with a high affinity. Moreover, the isolated nanobody is able to compete with the
      antibodies in the patient sera for the binding to the cancer cells. Conclusions:
      Results suggest that this nanobody has a specific reaction toward colorectal
      cells and can be used for further investigation on the tumor associated antigens
      or production of mimotopes useful for immunotherapy.

PMID- 29845055
TI  - TiO2 Nanoparticles as Potential Promoting Agents of Fibrillation of alpha
      Synuclein, a Parkinson's Disease-Related Protein.
AB  - Background: In recent years, nanomaterials have been widely used in large
      quantities which make people be more frequently exposed to the chemically
      synthesized nanoparticles (NPs). When NPs are introduced into an organism, they
      may interact with a variety of cellular components with yet largely unknown
      pathological consequences. Objective: It was found that NPs enhance the rate of
      protein fibrillation in the brain by decreasing the lag time for nucleation.
      Protein fibrillation is implicated in the pathogenesis of the several
      neurodegenerative diseases such as Parkinson's disease (PD). alpha-Synuclein
      (alphaS) is natively an unfolded protein which is involved in the pathogenesis of
      PD. In the present study, we have analyzed the effects of three different NPs on
      alphaS fibrillation. Materials and Methods: alphaS protein expression and purifi
      cation was done and fibrils formation was induced in the absence or presence of
      the three types of NPs (i. e., TiO2, SiO2, and SnO2). The enhancement of the
      fluorescence emission of Thiofl avin T (ThT) and transmission electron microscopy
      (TEM) were used to monitor the appearance and growth of the fibrils. The
      adsorption of alphaS monomers on the surface of NPs was investigated by tyrosine
      fluorescence emission measurements. Results: We found that TiO2-NPs enhances
      alphaS fibril formation even at a concentration of 5 MUg.mL-1, while the two
      other NPs show no significant effect on the kinetics of the fibrillation.
      Intrinsic tyrosine emission measurement has confirmed that the TiO2-NPs interact
      with alphaS fibrillation products. It is suggested that TiO2- NPs may enhance the
      nucleation of alphaS protein that leads to protein fibril formation. Conclusion:
      The fibrillization process of alphaS protein is profoundly affected by the
      presence of TiO2-NPs. This finding unveils the neurotoxicity potential of the
      TiO2-NPs, which may be considered as a probable risk for PD.

PMID- 29845056
TI  - Biosynthesis of Silver Nanoparticles Using Pine Pollen and Evaluation of the
      Antifungal Efficiency.
AB  - Background: Nanoparticles have been applied to medicine, hygiene, pharmacy and
      dentistry, and will bring significant advances in the prevention, diagnosis, drug
      delivery and treatment of disease. Green synthesis of metal nanoparticles has a
      very important role in nanobiotechnology, allowing production of non-toxic and
      eco-friendly particles. Objectives: Green synthesis of silver nanoparticles
      (AgNPs) was studied using pine pollen as a novel, cost-effective, simple and non
      hazardous bioresource. The antifungal activity of the synthesized AgNPs was
      investigated in vitro. Materials and Methods: Biosynthesis of AgNPs was conducted
      using pollen of pine (as a novel bioresource) acting as both reducing and capping
      agents. AgNPs were characterized using UV-visible spectroscopy, X-ray diffraction
      and transmission electron microscopy. In evaluation for antifungal properties,
      the synthesized AgNPs represented significant in vitro inhibitory effects on
      Neofusicoccum parvum cultures. Results: Pine pollen can mediate biosynthesis of
      colloidal AgNPs with an average size of 12 nm. AgNPs were formed at 22  degrees C
      and observed to be highly stable up to three months without precipitation or
      decreased antifungal property. AgNPs showed significant inhibitory effects
      against Neofusicoccum parvum. Conclusion: The first report for a low-cost,
      simple, well feasible and eco-friendly procedure for biosynthesis of AgNPs was
      presented. The synthesized AgNPs by pine pollen were nontoxic and eco-friendly,
      and can be employed for large-scale production. The nanoparticles showed strong
      effect on quantitative inhibition and disruption of antifungal growth.

PMID- 29845057
TI  - Production of Marker-free Transgenic Rice (Oryza sativa L.) with Improved
      Nutritive Quality Expressing AmA1.
AB  - Background: Rice seed proteins are lacking essential amino acids (EAAs). Genetic
      engineering offers a fast and sustainable method to solve this problem as it
      allows the specific expression of heterologous EAA-rich proteins. The use of
      selectable marker gene is essential for generation of transgenic crops, but might
      also lead to potential environmental and food safety problems. Therefore, the
      production of marker-free transgenic crops is becoming an extremely attractive
      alternative and could contribute to the public acceptance of transgenic crops.
      Objectives: The present study was conducted to examine whether AmA1 can be
      expressed specifically in rice seeds, and generate marker-free transgenic rice
      with improved nutritive value. Materials and Methods:AmA1 was transferred into
      rice using Agrobacterium-mediated co-transformation system with a twin T-DNA
      binary vector and its integration in rice genome was confirmed by southern blot.
      Transcription of AmA1 was analyzed by Real-Time PCR and its expression was
      verified by western analysis. Protein and amino acid content were measured by the
      Kjeldahl method and the high-speed amino acid analyzer, respectively. Results:
      Five selectable marker-free homozygous transgenic lines were obtained from the
      progeny. The expression of recombinant AmA1 was confirmed by the observation of a
      35 kDa band in SDS-PAGE and western blot. Compared to the wild-type control, the
      total protein contents in the seeds of five homozygous lines were increased by
      1.06~12.87%. In addition, the content of several EAAs, including lysine,
      threonine, and valine was increased significantly in the best expressing line.
      Conclusions: The results indicated that the amino acid composition of rice grain
      could be improved by seed-specific expression of AmA1.

PMID- 29845058
TI  - Antimicrobial Activity of Chitosan Film Forming Solution Enriched with Essential
      Oils; an in Vitro Assay.
AB  - Background: The resistance of the bacteria and fungi to the innumerous
      antimicrobial agents is a major challenge in the treatment of the infections
      demands to the necessity for searching and finding new sources of substances with
      antimicrobial properties. The incorporation of the essential oils (EOs) in
      chitosan film forming solution may enhance antimicrobial properties. However, its
      use as the feeding additive in the poultry nutrition needs to clarify the
      product's activity against both pathogen and the useful microbes in the
      gastrointestinal tract. Objectives: In the present study, we carried out an in
      vitro investigation and evaluated the antimicrobial activity of chitosan film
      forming solution incorporated with essential oils (CFs+EOs) against microbial
      strains including Staphylococcus aureus, Escherichia coli, Enterococcus faecium,
      Lactobacillus rahmnosus, Aspergillus niger and Alternaria alternate. Material and
      Methods: In three replicates, the minimum inhibitory concentration (MIC) and the
      minimum bactericidal concentration (MBC) of different treatments including: 1-
      essential oils (EOs), 2- chitosan film solution (CFs), and 3-chitosan film
      solution enriched with EOs (CFs+EOs) were determined against above mentioned
      microbes. Results: The results indicated that the chitosan solution enriched with
      essential oils (CFs+EOs) is capable of inhibiting the bacterial and fungal growth
      even at the lowest concentrations. The MIC and MBC for all the antimicrobial
      agents against Escherichia coli and Staphylococcus aureus were very low compared
      to the concentrations needed to inhibit the growth of useful bacteria,
      Lactobacillus rahmnosu and Enterococcus faecium. The antifungal activity of
      chitosan was enhanced as the concentration of EOs increased in the film solution.
      Conclusion: Chitosan-EOs complexes are the promising candidate for novel contact
      antimicrobial agents that can be used in animal feeds.

PMID- 29845059
TI  - Production of Xanthanases by Paenibacillus spp.: Complete Xanthan Degradation and
      Possible Applications.
AB  - Background: A number of microorganisms and their enzymes have been reported as
      xanthan depolymerizers. Paenibacillus species are well-known polysaccharide
      hydrolyzing bacteria. However, Paenibacillus alginolyticus and Paenibacillus sp.
      XD are the only species in the genus which are now known to degrade xanthan.
      Objectives: Complete biodegradation of the xanthan exopolysaccharide is a rarely
      found capability among microorganisms. The aim of this study is to survey
      xanthanase producing bacteria with an appropriate bioactivity for the biopolymer
      degradation under different environmental conditions. Materials and Methods: The
      bacteria were isolated based on viscosity reduction of the xanthan solution.
      Bacterial isolates were identified using rep-PCR (repetitive element-based
      genomic fingerprinting) and 16S rDNA sequencing. Xanthanases were identified
      using rep-PCR (repetitive element-based genomic fingerprinting) and 16S rDNA
      sequencing. Xanthanases were characterized by measuring their activity at
      different temperatures, pH values, and NaCl concentrations. Degradation of other
      polysaccharides and xanthan degradation products were investigated based on the
      screening plate method and TLC (thin-layer chromatography), respectively.
      Results:Six isolates from different Paenibacillus species with a complete xanthan
      degrading capability were isolated from Urmia Lake. Phylogenetic analysis placed
      these strains within the genus Paenibacillus with the closest relatives that were
      found to be P. nanensis, P. phyllosphaerae, P. agaridevorans, P. agarexedens, and
      P. taohuashanense. These isolates displayed different levels of the xanthan
      biodegradation activity in temperatures ranging from 15 to 55 degrees C and pH
      values from 4 to 11. Xanthanolytic activity was generally prevented in presence
      of NaCl (> 0.1 mol.L-1). Furthermore, the isolated Paenibacillus spp. could
      degrade several other polysaccharides including xylan, CMC (carboxymethyl
      cellulose), starch, alginate, and pectin. Conclusion: Novel strains of the six
      different Paenibacillus species that were introduced in the present study are
      able to produce xanthanases with interesting characteristics. In light of the
      results from this study, special applications, particularly in healthcare,
      medicine, and the environment is hereby proposed for these enzymes.

PMID- 29845060
TI  - The Increase in Protein and Plasmid Yields of E. coli with Optimized
      Concentration of Ampicillin as Selection Marker.
AB  - Background:Escherichia coli is still the common host for ing and heterologous
      protein expression. Various strategies have been employed to increase protein
      expression in E. coli, but, it seems that external factors such as selection
      marker concentration can drastically affect the yield of protein and plasmid.
      Objectives: Alterations of protein expression and plasmid yields of E. coli in
      different concentrations of ampicillin, as selection marker, will be determined.
      In order to improve heterologous expression, the system will be redesigned and
      optimized. Materials and Methods: The expression cassette of codon optimized EGFP
      for E. coli was synthesized in pUC57. The pUC57-GFP was transformed into E. coli
      Top10F'. The expression of GFP was verified by SDS-PAGE and flow cytometry after
      induction by IPTG (0.5 mM) and incubation with 0, 100, 200 and 300 MUg.mL-1
      ampicillin. Plasmid copy numbers of samples were determined by Real-Time PCR on
      AMP gene using regression line of diluted standard curve. Results: GFP expressing
      clones formed fair green colonies on LB agar supplemented with 0.5 mM IPTG and
      showed fluorescence in FL1 filter of flow cytometry and an extra protein band on
      SDS-PAGE gel. The fluorescent intensity of GFP in 0, 100, 200 and 300 MUg.mL-1
      ampicillin in medium were 549.83, 549.78, 1443.52, 684.87, and plasmid copy
      numbers were 6.07*109 , 3.21*109 , 2.32*1010 , 8.11*108 , respectively. The
      plasmid yields were 55 ng.MUL-1, 69 ng.MUL-1, 164 ng.MUL-1 and 41 ng.MUL-1,
      respectively. Conclusion: Protein and plasmid yields of E. coli are variable in
      different concentrations of ampicillin and need to be optimized in newly designed
      expression systems. Protein and plasmid yield in the optimized concentration (200
      MUg.mL-1) was significantly (p < 0.01) higher than other doses.

PMID- 29845061
TI  - Biological Removal of the Mixed Pharmaceuticals: Diclofenac, Ibuprofen, and
      Sulfamethoxazole Using a Bacterial Consortium.
AB  - Background: The presence of pharmaceuticals at low concentrations (ng to MUg) in
      the environment has become a hot spot for researchers in the past decades due to
      the unknown environmental impact and the possible damages they might have to the
      plantae and fauna present in the aquatic systems, as well as to the other living
      organisms. Objectives: The aim of the present investigation was to develop a
      bacterial consortium isolated from different origins to evaluate the ability of
      such a consortium to remove a mixture of pharmaceuticals in the batch system at
      lab scale, as well as assessment of its resistance to the other micropollutants
      present in the environment. Material and Methods: Using a closed bottle test,
      biodegradation of the mixed pharmaceuticals including Diclofenac (DCF), Ibuprofen
      (IBU), and Sulfamethoxazole (SMX) (at a concentration of 3 mg.L-1 of each drug)
      by the bacterial consortium was investigated. The test was carried out under
      metabolic (pharmaceutical was used as the sole source of carbon) and co-metabolic
      condition (in the presence of glucose). Finally, the ability of the bacterial
      consortium to resist other micropollutants like antibiotics and heavy metals was
      investigated. Results: Under the metabolic condition, the mixed bacteria (i.e.,
      consortium) were able to metabolize 23.08% and 9.12% of IBU, and DCF at a
      concentration of 3 mg.L-1 of each drug, respectively. Whereas, in co-metabolic
      conditions, IBU was eliminated totally, in addition, 56% of the total
      concentration of DCF was removed, as well. In both metabolic and cometabolic
      conditions, removal of SMX was not observed. The selected bacteria were able to
      resist to most of the applied antibiotics and the used heavy metals, except
      mercury, where only one strain (S4) was resistant to the later heavy metal.
      Conclusion: Results suggest that the developed consortium might be an excellent
      candidate for the application in the bioremediation process for treating
      ecosystems contaminated with the pharmaceutical.

PMID- 29845062
TI  - Real-Time PCR: an Appropriate Approach to Confirm ssDNA Generation from PCR
      Product in SELEX Process.
AB  - Background: Aptamers are single stranded DNA (ssDNA) or RNA molecules. The
      potential of aptamers for binding to the different targets has made them be
      widely used as the preferred diagnostic and therapeutic tools. DNA aptamers
      present several advantages over the RNA oligonucleotides due to their higher
      stability, easier selection, and production. Selection of DNA aptamers which is
      facilitated through a systematic evolution of ligand by exponential enrichment
      (SELEX) method is much dependent on the successful conversion of double stranded
      DNA (dsDNA) to ssDNA. Objective: There are different methods available for ssDNA
      generation. While visualization of ssDNA is limited to the gelbased method, the
      method is not applicable in the initial rounds of SELEX due to more than 1015
      different sequences. This study was designed to evaluate the effi ciency of
      another technique for confi rming the ssDNA generation in comparison to the
      polyacrylamide electrophoresis (PAGE) analysis. Materials and Methods: Real-time
      PCR was employed in the present study for PCR amplifi cation of the initial
      library that was followed by enzymatic digestion of the dsDNA. Subsequently
      melting curve analysis was carried out to evaluate ssDNA generation from dsDNA.
      Moreover, PAGE analysis was performed and the results were compared with the melt
      curve analysis. Results: The melt curves, revealed dsDNA conversion to the ssDNA
      based on a significant reduction of Tm from 73.8 to 41.5  degrees C. Applying
      PAGE analysis, it was not effectively feasible to show ssDNA generation from the
      corresponding initial dsDNA library, while, it was effi cient enough to confirm
      ssDNA generation in accordance with the increasing the number of SELEX rounds.
      Conclusion: The present study has proven the applicability of the real-time PCR
      as a suitable confirmatory technique for validating ssDNA generation in the DNA
      aptamer selection process for the initial library preparation.

PMID- 29845063
TI  - Bone Marrow Stromal Cells Associated with Poly L-Lactic-Co-Glycolic Acid (PLGA)
      Nanofiber Scaffold Improve Transected Sciatic Nerve Regeneration.
AB  - Background: Although peripheral nerves show capacity for regeneration after
      injury to a certain extent, the extent of regeneration is not remarkable.
      Previous studies have suggested that through the production of growth factors or
      extracellular matrix components, mesenchymal stem cells may enhance nerve
      regeneration. Objectives: In the present study, the therapeutic potency of the
      Bone Marrow Stromal Cells (BMSCs) associated with Poly L-lactic-co-glycolic acid
      (PLGA) nanofiber Scaffolds on rat sciatic nerve repair was evaluated. Material
      and Methods: Thirty adult male Wistar rats (220-250 g) were divided randomly into
      six groups, including control 1 (transected sciatic nerve), control 2 (transected
      sciatic nerve and stitched), Sham, PLGA, BMSCs, and PLGA+BMSCs. Functional
      recovery was evaluated at the end of 2nd, 4th, 6th, and 8th weeks after surgery
      using sciatic functional index (SFI) and hot water test. After killing all rats
      at the end of 8th week, their sciatic nerves were removed, fixed, and processed
      for the histological examination and analysis by the Motic software. Results: A
      significant recovery of the sciatic nerve function was observed in the PLGA+BMSCs
      transplanted group at the 8th week after surgery as demonstrated by SFI and hot
      water findings. Histological examinations also showed a significant improvement
      in the PLGA+BMSCs group compared to the control 1, 2, Sham, PLGA and BMSCs
      groups. Conclusion: BMSCs associated with PLGA nanofiber scaffold might be useful
      for improving the functional peripheral nerve repair having some clinical
      outcome.

PMID- 29845064
TI  - Induction of Apoptosis in Human Breast Cancer MCF-7 Cells by a Semi-Synthetic
      Derivative of Artemisinin: A Caspase-Related Mechanism.
AB  - Background: Artesunate has recently been used in some pharmacological preparation
      to induce tumor cell apoptosis. The drug is a semi-synthetic derivative of
      artemisinin, traditionally used for its antimalarial. However, up to now, its
      anticancer mechanism against different types of tumors is not known. Objectives:
      The most important purposes of the present research was firstly investigating
      induction of apoptosis on human breast cancer MCF-7 cells by the drug and, in the
      second place, introducing its possible mechanism of action. Materials and
      Methods: The MTT assay was used to investigate the inhibitory effect of
      artesunate on growth of breast cancer MCF-7 cells. For this aim, different
      concentrations of artesunate were used to treat the cells and flow cytometry
      assay was done followed by annexin V-FITC/PI staining. The activities of caspase
      3, -8 and -9 were then determined by relative assay kits. Results: Based on the
      results from MTT assay, it was found that artesunate could significantly inhibit
      the growth of MCF-7 cells in a dose- and time-dependent manner. On the other
      hand, the flow cytometry findings showed that the anti-proliferative activity of
      artesunate on MCF-7 cells is due to apoptosis. Besides, caspase colorimetric
      assays revealed a significant rise in cellular levels of the initiators (caspase
      8 and -9) and effector (caspase-3) in the cells treated by artesunate.
      Conclusions: According to our results, it could be concluded that artesunate
      could inhibit the growth of MCF-7 breast cancer cells through induction of
      apoptosis by intrinsic and extrinsic caspase-dependent pathways. Therefore, we
      claim that artesunate could be introduced as a suitable candidate for the
      treatment of the breast cancer.

PMID- 29845065
TI  - Stimulation of Camel Polyclonal Antibody against Human T cell Immunoglobulin and
      Mucin 3.
AB  - Background: T cell Immunoglobulin, Mucin (TIM)-3, is a type I transmembrane
      glycoprotein belonging to TIM family. This receptor expresses on T helper type 1
      (Th1) cells that binds to galectin-9 (Gal9); inducing an inhibitory signal. As a
      result, apoptosis of Th1 cells occurs and cytotoxicity of CD8 T cells becomes
      evident in vitro. Therefore, this immunomodulatory molecule may be used as a
      novel target for clinical purposes. The production of camel polyclonal antibodies
      against TIM-3-expressing cell line was the purpose of this study. Objectives: In
      this study, we aimed to use HEK 293 cells expressing human TIM-3 to obtain camel
      polyclonal antibody against TIM-3 by immunization. Materials and Methods: A pre
      synthesized human TIM-3cDNA was inserted into pcDNA3.1 plasmid and the new
      construct was transfected in HEK cell. TIM-3 expression was confirmed by qRT-PCR
      and flow cytometry. A camel (6 months old) was immunized with the lysate prepared
      from rTIM-3 expressing HEK cells 4 times. The anti-TIM-3 antibody level was
      evaluated using ELISA method. Results: TIM-3 was successfully cloned in HEK cells
      with 88% success rate. High level of anti-TIM-3 antibody was detected in the
      serum of the camel immunized with the recombinant cell lysate, after final
      injection. Conclusions: Our rhTIM-3 cell display system can be useful for future
      diagnostic or therapeutic approaches.

PMID- 29845066
TI  - Designing Two Individual AcMNPV Polyhedrin-Plus Bac-to-Bac Expression System in
      order to Express GFP and CPV-VP2 in Insect Cells.
AB  - Background: The importance of viral protein-2 (VP2) of canine parvovirus (CPV) in
      binding to human cancer cells, production of veterinary vaccines and diagnostic
      kits has motivated several researches on producing this protein. Objectives: Our
      purpose was to construct recombinant bacmid shuttle vectors expressing VP2 of CPV
      using Bac-to-Bac baculoviral expression system. Materials and Methods: Mini-Tn7
      transposones engineered in pFastBac1 donor vectors were used to construct
      expression cassettes of GFP and CPV-VP2. The plasmids were transferred into E.
      coli DH10Bac competent cells. Site-specific transposition of the genes into
      bacmid was accomplished using helper plasmid. Occurrence of Transposition was
      confirmed via PCR using specific primers and PUC/M13 universal primers. The
      recombinant bacmid DNAs were transfected into Sf9 cells using cationic lipids to
      generate new recombinant baculoviruses expressing GFP and CPV-VP2. GFP and VP2
      expressions were evaluated by fluorescence microscopy and western analysis,
      respectively. Results: Cloning, subcloning and recombination processes of both
      GFP and VP2 were accomplished and verified. Accuracy of transfection process was
      confirmed by GFP fluorescence microscopy.VP2 expression was verified by SDS-PAGE
      and western analysis. Conclusions: Two Bac-to-Bac expression systems were
      designed to produce recombinant VP2 and GFP in insect cells.

PMID- 29845067
TI  - Anti-Vasculogenic Activity of a Polysaccharide Derived from Brittle Star via
      Inhibition of VEGF, Paxillin and MMP-9.
AB  - Background: Bioactive compounds such as terpenoids, chondroitin sulfate, and
      polysaccharides with added value can be found in prestine marine creatures. These
      compounds often do have highly valuable therapeutic applications such as being
      antioxidant, antitumorogenic, anti-inflammatory and anti-angiogenic. For the
      latter, varieties of angiogenesis factors can suppress this issue within the
      bodily tissues. Objectives: The anti-angiogenic and anti-metastatic capacity of a
      polysaccharide derived from brittle star was investigated. Material and Methods:
      The anti-proliferative effect of derived polysaccharide on umbilical vein
      endothelial cells (HUVEC) was measured using MTT (dimethyl thiazol-2-yl]-2,5
      diphenyl tetrazolium bromide) assay. The anti-angiogenic effect of the isolated
      polysaccharide was examined by Chorioallantoic membrane (CAM) assay. The
      transcriptional expression of VEGF (Vascular Endothelial Growth Factor) was
      evaluated by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). The anti
      metastatic activity was investigated via scratch-wound healing assay. The levels
      of Paxillin and Matrix Metalloproteinase-9 (MMP-9) expression were analyzed by RT
      PCR. Statistical analysis and mean comparisons (p< 0.05) were carried out by SPSS
      16. Results: Our results elucidated that the brittle star isolated polysaccharide
      exerted a dose dependent cytotoxic effect on the HUVEC endothelial cells. The CAM
      assay exhibited potent anti-angiogenic activity in vivo. The RT-PCR analysis
      showed that the extracted polysaccharide (40, 60 ug.mL-1) down-regulated the VEGF
      expression. Further, the diminished attachment of endothelial cells demonstrated
      that the anti-invasiveness of the derived polysaccharide (25, 50 ug.mL-1) was
      administrated via down-regulation of paxillin and MMP-9 mRNA expression.
      Conclusions: Taken together, these results indicated that the polysaccharide
      extracted from brittle star was able to decrease the viability of the HUVEC
      cells, to suppress angiogenesis, and possibly act as a natural anti-angiogenic
      and anti-metastatic marine organic compound against angiogenesis related
      pathologies.

PMID- 29845069
TI  - Construction of New Genetic Tools as Alternatives for Protein Overexpression in
      Escherichia coli and Pseudomonas aeruginosa.
AB  - Background:Pseudomonas protein expression in E. coli is known to be a setback due
      to significant genetic variation and absence of several genetic elements in E.
      coli for regulation and activation of Pseudomonas proteins. Modifications in
      promoter/repressor system and shuttle plasmid maintenance have made the
      expression of stable and active Pseudomonas protein possible in both Pseudomonas
      sp. and E. coli. Objectives: Construction of shuttle expression vectors for
      regulation and overexpression of Pseudomonas proteins in Pseudomonas sp. and E.
      coli. Materials and Methods:Pseudomonas-Escherichia shuttle expression vectors,
      pCon2(3), pCon2(3)-Kan and pCon2(3)-Zeo as well as E. coli expression vectors of
      pCon4 and pCon5 were constructed from pUCP19-, pSS213-, pSTBlue-1- and
      pPICZalphaA-based vectors. Protein overexpression was measured using elastase
      strain K as passenger enzyme in elastinolytic activity assay. Results: The
      integration of two series of IPTG inducible expression cassettes in pCon2(3),
      pCon2(3)-Kan and pCon2(3)-Zeo, each carrying an E. coli lac-operon based
      promoter, Plac, and a tightly regulated T7(A1/O4/O3) promoter/repressor system
      was performed to facilitate overexpression study of the organic solvent-tolerant
      elastase strain K. These constructs have demonstrated an elastinolytic fold of as
      high as 1464.4 % in comparison to other published constructs. pCon4 and pCon5, on
      the other hand, are series of pCon2(3)-derived vectors harboring expression
      cassettes controlled by PT7(A1/O4/O3) promoter, which conferred tight regulation
      and repression of basal expression due to existence of respective double operator
      sites, O3 and O4, and lacIq. Conclusions: The constructs offered remarkable
      assistance for overexpression of heterogeneous genes in Pseudomonas sp. and E.
      coli for downstream applications such as in industries and structural biology
      study.

PMID- 29845068
TI  - Expression Profiling of Hspb1 and Tp53 Genes through RT-qPCR in Different Cancer
      Types of Canis familiaris.
AB  - Background: Diagnostic molecular marker studies are in vogue to have insight of
      most prevalent animal diseases including cancer. Objectives: Gene expression
      profiling of pro and anti-apoptotic genes was conducted in dog Lymphoma, CTVT,
      SCC, granuloma, perianal adenocarcinoma and mammary tumors. Materials and
      Methods: Cancerous tissues of 21 affected animals were obtained. Total RNA was
      extracted followed by cDNA synthesis. Comparative Ct method via Taqman assay (RT
      qPCR) was used to quantify corresponding mRNA molecules, Tp53 and Hspb1, as
      normalized by GAPDH as the reference gene . Results:Hspb1 showed ectopic
      expression in lymphoma, CTVT and mammary tumors; its down-regulation was observed
      in granuloma and oral SCC with fold difference (FD) of +/-35. Similarly, Tp53 as
      the tumor suppressor gene with pro-apoptotic properties, showed up-regulation in
      all tumor types, notably 80% of mammary tumors and 60% of CTVT. The FD values
      were 33.31 and 2.27, respectively. Conclusion: Altered transcriptomic response of
      Hspb1 and Tp53 was observed in all cancer types of Canis familiaris. The
      resulting profile depicts the involvement of the genes in cancer pathways. Thus,
      the data might be helpful for diagnosis, prognosis, identification and
      classification of these widespread neoplasms in this species.

PMID- 29845070
TI  - Agrobacterium-Mediated Transformation of the Oryza sativa Thaumatin-Like Protein
      to Canola (R Line Hyola308) for Enhancing Resistance to Sclerotinia sclerotiorum.
AB  - Background: Canola is an agro-economically oilseed crop. Yield loss due to fungal
      disease of stem rot caused by Sclerotinia sclerotiorum is a serious problem in
      canola cultivation. Thaumatin-like proteins are large groups of the pathogenesis
      related proteins which provide resistance to the fungal infection in response to
      invading pathogens and play a key role in plant defense system. Objectives:
      Transformation of the rice tlp into canola via Agrobacterium-mediated
      transformation and evaluation of the antifungal activity of the expressed TLP in
      the transgenic events on the S. sclerotiorum growth was subject to investigation.
      Materials and methods: The canola (R line Hyola308) was used for transformation
      experiment. The vector, pBITLPRA1, was used for the stable transformation. The
      PCR and southern blotting techniques were used to confirm transgene's presence in
      the transgenic canola events. Antifungal activity of transgenic plants was
      evaluated by the radial diffusion and spore germination assays. T2 transgenic
      plants were evaluated by the intact leaf inoculation method in greenhouse assay.
      Results: In this study, pBITLPRA1 construct containing tlp gene was introduced
      into canola and the transformed plants were verified by PCR. The glucanase
      activity of tlp gene in T0 generation was measured and transgenic plants with
      high activity were assessed by Southern blot analysis to confirm the copy number
      of the gene. Also, antifungal activity of the single copy T0 transgenic plants
      against Sclerotinia sclerotiorum was evaluated by radial diffusion and spore
      germination assays. In greenhouse assay, evaluation of T2 transgenic plants by
      the intact leaf inoculation method demonstrated that following the infection with
      S. sclerotiorum, there was a significant reduction in the lesion's diameter in
      transgenic lines compared to the non-transgenic ones. Conclusions: These results
      revealed that expression of TLP has an inhibitory effect against fungus compared
      to non-transgenic plants both in vitro and in vivo (i.e., greenhouse condition).
      These transgenic lines could be used as the additional sources of disease
      resistance for canola breeding program.

PMID- 29845071
TI  - Designing and Validation of One-Step T-ARMS-PCR for Genotyping the eNOS rs1799983
      SNP.
AB  - Background: The transversion of G to T (G894T) in human endothelial nitric oxide
      synthase (eNOS) gene has profound effects such as male infertility, recurrent
      miscarriage, multiple sclerosis and cardiovascular diseases. Objectives:
      Development of a new Multiplex Tetra-Primer Amplification Refractory Mutation
      System - Polymerase Chain Reaction (T-ARMS-PCR) for detection of rs1799983
      (G894T) in the human eNOS was sought. Materials and Methods: A T-ARMS-PCR for
      rs1799983 polymorphism in a single-step PCR was carried out, and the results were
      confirmed by PCR-RFLP technique in 82 infertile men with varicocele. Results: The
      results showed that GG (varicocele infertile men), GT and TT genotypes appear to
      be 53.65%, 34.14%, and 12.19%, respectively. Full accordance between PCR-RFLP and
      T-ARMS-PCR methods for genotyping of rs1799983 polymorphism was found.
      Conclusions: This is the first work that describes a rapid, relatively cheap,
      high throughput detection of G894T polymorphism in eNOS that can be used in large
      scale clinical studies.

PMID- 29845072
TI  - From a Chemical Matrix to Biologically/Biomechanically-Defined Matrices
      Optimizing/Correlating Growth Rate and Differentiation Potential of Human Adipose
      Derived Mesenchymal Stem Cells.

PMID- 29845073
TI  - Characterization of the Electric Current Generation Potential of the Pseudomonas
      aeruginosa Using Glucose, Fructose, and Sucrose in Double Chamber Microbial Fuel
      Cell.
AB  - Background: Different concentrations of the simple carbon substrates i.e.
      glucose, fructose, and sucrose were tested to enhance the performance of the
      mediator-less double chamber microbial fuel cell (MFC). Objectives: The power
      generation potential of the different electron donors was studied using a
      mesophilic Fe (III) reducer and non-fermentative bacteria Pseudomonas aeruginosa
      isolated from municipal wastewater. Materials and Methods: A double chamber MFC
      was operated with three different electron donors including glucose, sucrose, and
      fructose. Substrate utilization pattern was determined through chemical oxygen
      demand (COD) removal rate and voltage generation. In addition, electrochemical,
      physicochemical, and microscopic analysis of the anodic biofilm was conducted.
      Results:P. aeruginosa was proven to effectively utilize hexose and pentose sugars
      through anode respiration. Higher power density was generated from glucose (136
      +/- 87 mWm2) lead by fructose (3.6 +/- 1.6 mWm2) and sucrose (8.606 +/- mWm2).
      Furthermore, a direct relation was demonstrated between current generation rate
      and COD removal efficiency. COD removal rates were, 88.5% +/- 4.3%, 67.5% +/-
      2.6%, and 54.2% +/- 1.9% with the three respective sugars in MFC. Scanning
      electron microscopy (SEM) demonstrated that the bacterial attachment was
      considerably abundant in glucose fed MFC than in the fructose and sucrose
      operated MFC. Conclusion: This study has revealed that electron donor type in the
      anodic compartment controls the growth of anodic biofilm or anode-respiring
      bacteria (ARB).

PMID- 29845074
TI  - Enhancement of Alpha 1-antitrypsin Production in Pichia pastoris by Designing and
      Optimizing Medium Using Elemental Analysis.
AB  - Background: Human alpha 1-antitrypsin (AAT) is a monomeric glycosylated protein;
      it is the potent inhibitor of a whole range of serine proteases and protects
      tissues against their destructive effects. The human plasma-derived AAT, which is
      currently used to augment the AAT level in patients, is limited due to high cost
      and source limitation. Recombinant production of AAT can be considered as a
      potential alternative. Objectives: This study aims to develop and optimize a new
      chemically defi ned medium based on an elemental analysis of the yeast Pichia
      pastoris for an effi cient culture of the recombinant yeast-producing secretory
      AAT. Materials and Methods: An elemental analysis of Carbon (C), Hydrogen (H),
      Nitrogen (N), Sulfur (S); CHNS in its abbreviated form, and metallic elements was
      performed to determine the exact molecular constituent of the P. pastoris. The
      medium components were selected according to the obtained formula; they were
      optimized by the response surface methodology (RSM). The grown yeast cell was
      measured at the end of 18 h glycerol batch culture. The amounts of AAT production
      and elastase inhibitory capacity (EIC) were measured at the end of three days'
      methanol feeding. Results: The optimized medium compositions consist of glycerol
      (40 g.L-1), KH2PO4 (24.78 g.L-1), NaCl, (0.88 g.L-1), MgSO4 .7H2 O (1.95 g.L-1),
      (NH4 )2 SO4 (22.76 g.L-1), and trace elements (20 mL.L-1). The presented
      quadratic models show that KH2 PO4 and (NH4)2 SO4, are the most abundant ones in
      the P. pastoris biomass and have the greatest effect on the cell growth, EIC, and
      AAT protein production responses. Conclusions: According to the results of this
      study, it can be concluded that the characterizing cell composition formula could
      be considered as an appropriate method to design culture media in order to
      improve cell growth and productivity. Compared to the common P. pastoris
      chemically defi ned media, FM22 and BSM, production of AAT protein increased by
      1.5 and 1.4 times, respectively, in this new medium.

PMID- 29845075
TI  - Purification of Endoxylanase from Bacillus pumilus B20 for Production of
      Prebiotic Xylooligosaccharide Syrup; An In vitro Study.
AB  - Background: The need for more cost-effective compounds is imperative because the
      demand for prebiotic compounds is ever on the rise. Objective: The focus of this
      study is the purification of the endoxylanase from Bacillus pumilus B20 and its
      application in a cost-effective production of the prebiotic xylooligosaccharide
      (XOS) syrup having a high concentration of oligosaccharides. Materials and
      Methods: The extracellular endoxylanase was purified using ammonium sulphate
      fractionation, DEAE anion exchange, and Sephacryl gel filtration chromatography.
      The enzymatically produced XOS was used in the preparation of XOS syrup adopting
      the method of ultrafiltration with 10 and 3 kDa molecular weight cut-off (MWCO)
      membranes. Culture-dependent technique for the bacterial enumeration using
      selective probiotic microorganisms in an in vitro analysis was employed to
      confirm the prebiotic nature of XOS syrup. Results: The molecular mass of the
      purified xylanase (XylB) was found to be approximately 85 kDa with the optimum pH
      and temperature of 6.5 and 60  degrees C, respectively. XylB hydrolyzed the xylan
      and produced short-chain xylooligosaccharides (XOS). At the end of the two-step
      ultrafiltration process, the hydrolysate was refi ned to form XOS syrup (44.4%)
      consisting of XOS with a degree of polymerization (DP) between 2 and 5, and >5.
      Among all the tested probiotic strains, Lactobacillus brevis exhibited maximum
      growth in the presence of 0.5% XOS syrup with a specific growth rate of 1.2 h-1.
      Conclusion: Through this study, we have identified a method to produce XOS syrup
      that can be used as an effective prebiotic supplement for the growth of several
      probiotic strains. Human gut probiotics was used as a model system for in vitro
      analysis of prebiotic oligosaccharide XOS, but for further confirmation of the
      prebiotic activity, in vivo feeding studies using animal models are needed to be
      carried out.

PMID- 29845076
TI  - Effect of Simulated Microgravity Conditions on Differentiation of Adipose Derived
      Stem Cells towards Fibroblasts Using Connective Tissue Growth Factor.
AB  - Background: Mesenchymal stem cells (MSCs) are multipotent cells able to
      differentiating into a variety of mesenchymal tissues including osteoblasts,
      adipocytes and several other tissues. Objectives: Differentiation of MSCs into
      fibroblast cells in vitro is an attractive strategy to achieve fibroblast cell
      and use them for purposes such as regeneration medicine. The goal of this study
      was investigate the simulated microgravity effect on differentiation of Adipose
      Derived Stem Cells (ADSCs) to fibroblasts. Materials and Methods: To fibroblast
      differentiation 100 ng.mL-1 of connective tissue growth factor (CTGF), and for
      simulation microgravity, 2D clinostat was used. After isolation the human ADSCs
      from adipose, cells were passaged, and at passages 3 they were used for
      characterization and subsequent steps. After 7 days of CTGF and simulated
      microgravity treatment, proliferation, and differentiation were analyzed
      collectively by MTT assay, quantitative PCR analyses, and Immunocytochemistry
      staining. Results: MTT assay revealed that CTGF stimulate the proliferation but
      simulated microgravity didn't have statistically significant effect on cell
      proliferation. In RNA level the expression of these genes are investigated:
      collagen type I (COLI), elastin (ELA), collagen type III (ColIII), Matrix
      Metalloproteinases I(MMP1), Fibronectin 1 (FN1), CD44, Fibroblast Specific
      protein (FSP-1), Integrin Subunit Beta 1 (ITGB1), Vimentin (VIM) and Fibrillin
      (FBN). We found that expression of ELN, FN1, FSP1, COL1A1, ITGB1, MMP1 and COL3A1
      in both condition, and VIM and FBN1 just in differentiation medium in normal
      gravity increased. In protein level the expression of COL III and ELN in
      simulated microgravity increased. Conclusions: These findings collectively
      demonstrate that the simulated microgravity condition alters the marker
      fibroblast gene expression in fibroblast differentiation process.

PMID- 29845077
TI  - Ginsenoside Rg5: Rk1 Exerts an Anti-obesity Effect on 3T3-L1 Cell Line by the
      Downregulation of PPARgamma and CEBPalpha.
AB  - Background: Obesity, a global health problem and a chronic disease, is associated
      with increased risk of developing type 2 diabetes and coronary heart diseases. A
      wide variety of natural remedies have been explored for their obesity treatment
      potential. Objective: The anti-adipogenic effect of ginsenoside Rg5:Rk1 (Rg5:Rk1)
      on 3T3-L1 mature adipocytes was investigated. Materials and Methods: To elucidate
      the anti-obesity effect of Rg5:Rk1, a mixture of protopanaxadiol type
      ginsenosides isolated from Panax ginseng Meyer in a 3T3-L1 adipocytes. In order
      to determine the anti-obesity effect of Rg5:Rk1, based on oil Red O Staining,
      triglyceride (TG) content in adipose cells was assessed. Furthermore, to
      elucidate the possible mechanism of Rg5:RK1 effect on lipid accumulation, mRNA
      and protein expression analyses of adipocyte markers such as STAT3, PPARgamma,
      CBEPalpha and ap2 were carried out. Results: Rg5:Rk1 treatment showed an
      inhibition of lipid droplet accumulation and decrease of TG content. In addition,
      expression of STAT3, PPARgamma, CEBPalpha and ap2 were decreased in a dose
      dependent manner. Similarly, the Rg5:Rk1 treatment reduced PPARgamma and
      CEBPalpha protein expression. Conclusion: Rg5:Rk1 treatment exhibits anti
      adipogenic activity by down-regulation of the STAT3/ PPARg/CEBPa signaling
      pathway in 3T3-L1 adipocyte cell line.

PMID- 29845078
TI  - Sugarcane Mosaic Virus-Based Gene Silencing in Nicotiana benthamiana.
AB  - Background: Potyvirus-based virus-induced gene silencing (VIGS) is used for
      knocking down the expression of a target gene in numerous plant species.
      Sugarcane mosaic virus (SCMV) is a monopartite, positive single strand RNA virus.
      Objectives: pBINTRA6 vector was modifi ed by inserting a gene segment of SCMV in
      place of Tobacco rattle virus (TRV) genome part 1 (TRV1 or RNA1) and the two
      nonstructural proteins of TRV2(RNA2). Materials and Methods: SCMV construct was
      inoculated into 3-4 weeks Nicotiana benthamiana plant leaves either by using a
      needleless syringe or applying pricking with a toothpick. Results: The construct
      (SCMV-RNA2) successfully induced post-transcriptional gene silencing (PTGS) of
      the target genes GFP and ChlI through agroinoculation proving that SCMV is a
      substitute of the RNA1, which plays a pivotal role in the systemic gene
      silencing. 2-3-weeks of post inoculation, target genes' silencing was observed in
      the newly developed noninoculated leaves. Conclusions: The newly developed
      construct expresses the knocked down of the endogenous as well as exogenous genes
      and only four weeks are required for the transient expression of the gene
      silencing based on SCMV-VIGS system.

PMID- 29845079
TI  - Antimicrobial and Antioxidant Activity of the Biologically Synthesized Tellurium
      Nanorods; A Preliminary In vitro Study.
AB  - Background: Recent theranostic (therapeutic or diagnostic) applications of
      tellurium nanoparticles have attracted a great interest for development of
      different methods for synthesis of this valuable nanostructure, especially via
      biological resources. Objectives: In the present study, the antimicrobial and
      antioxidant effects of the tellurium nanorods (Te NRs) biosynthesized by a
      bacterial strain Pseudomonas pseudoalcaligenes strain Te were evaluated.
      Materials and Methods: The antimicrobial effect of Te NRs and potassium tellurite
      against different bacterial and fungal pathogens was assessed by microdilution
      method. Furthermore, the disk diffusion method was used to evaluate the
      antibacterial effect of the biogenic Te NRs and potassium tellurite against
      methicillin-resistant Staphylococcus aureus, alone or in combination with various
      antibiotics. Also, the biogenic Te NRs were investigated for antioxidant activity
      using 2, 2-diphenyl- 1-picrylhydrazyl (DPPH) scavenging activity and reducing
      power assay. Results: Transmission electron micrograph (TEM) of the purified Te
      NRs showed individual and rod-shaped nanostructure (~22 nm diameter by 185 nm in
      length). Based on the data obtained from both microdilution and disk diffusion
      method the K2 TeO3 exhibited a higher antibacterial and antifungal activity
      compared to the Te NRs. The measured IC50 for the biogenic Te NRs (i.e. DPPH
      radical scavenging activity) was found to be 24.9 MUg.mL-1, while, K 2 TeO3 has
      represented only 17.6 +/- 0.8 % DPPH radical scavenging effect at the
      concentration of 160 MUg.mL-1. The reducing power assay revealed a higher
      electron-donating activity for Te NRs compared to K2TeO3. Conclusions: Based on
      the data obtained from both microdilution and disk diffusion method the K2TeO3
      exhibited a higher antimicrobial and antifungal activity than Te NRs. Te NRs
      didn't show the antibacterial effect against the tested bacterial strain: MRSA
      and showed an inhibitory effect and antibacterial activity of the effective
      antibiotics. However, more studies should be performed to explore the action
      mechanism of the produced biogenic Te NRs.

PMID- 29845080
TI  - Sustained Release of Green Tea Polyphenols from Liposomal Nanoparticles; Release
      Kinetics and Mathematical Modelling.
AB  - Background: Green tea polyphenols (GTP) are known to have several health
      benefits. In spite of these benefits, its application as a therapeutic agent is
      limited due to some of its limitations such as stability, bioavailability, and
      biotransformation. To overcome these limitations, liposomal nanoparticles have
      been used as a carrier of the GTP. Objective: Encapsulation of GTP to the
      liposomal nanoparticles in order to achieve a sustained release of the GTP and to
      determine the drug release kinetics and the mechanism of the release. Materials
      and Methods: GTP encapsulated liposomal nanoparticles were prepared using
      phosphatidyl choline and cholesterol. The synthesized particles were
      characterized for their particle size and morphology. In vitro release studies
      were carried out, followed by drug release kinetics, and determining the
      mechanism of release. In vitro, antioxidant assay was determined following 2,2
      diphenyl-1-picrylhydrazyl (DPPH) method. Results: Atomic force microscope (AFM)
      and high resolution scanning electron microscope (HR SEM) images showed spherical
      particles of the size of 64.5 and 252 nm. An encapsulation efficiency as high as
      77.7% was observed with GTP concentration of 5 mg.mL-1. In vitro release studies
      showed that the loading concentrations of GTP were independent to the cumulative
      percentage of the drug release. GTP release by varying the pH and temperature
      showed a direct correlation between the release parameter and the percentage of
      drug release. The higher the pH and temperature, the higher was the percentage of
      the drug release. The release data showed a good correlation with Zero order
      kinetics and the mechanism of the release being anomalous mode. Radical
      scavenging activity of the released GTP showed a potent scavenging activity.
      Conclusion: GTP encapsulated liposomal nanoparticles could be used as a delivery
      vehicle for achieving a sustained release.

PMID- 29845081
TI  - Differential Expression of Mitochondrial Manganese Superoxide Dismutase (SOD) in
      Triticum aestivum Exposed to Silver Nitrate and Silver Nanoparticles.
AB  - Background: The increasing use of nanoparticles (NPs) may have negative impacts
      on both organisms and the environment. Objectives: The differential expression of
      mitochondrial manganese superoxide dismutase (MnSOD) gene in wheat in response to
      silver nitrate nanoparticles (AgNPs) and AgNO3 was investigated. Materials and
      Methods: A quantitative Real-Time RT-PCR experiment was carried out with MnSOD
      gene using RNAs isolated from wheat shoots treated for 0, 2, 6, 12, and 24 h with
      100 mg.L-1 of either AgNO 3 or AgNPs. Results: The results of this study showed
      that both treatments cause changes in the expression pattern of the MnSOD gene.
      While 2 and 6 h following the beginning of the stress, MnSOD expression was up
      regulated significantly, in response to AgNO 3 (1.4 and 2.8 fold, respectively),
      in response to AgNPs, it was up-regulated significant only after 6 h (1.6 fold),
      compared with the control. The gene expression, after 12 h in response to AgNO3
      and AgNPs were downregulated significantly (0.7 and 0.8 fold, respectively), and
      in the next 12 h , the expression appeared to be similar to the control.
      Conclusion: Exposure to both AgNPs and Ag ions led to a significant increase in
      MnSOD expression, but AgNO 3 changed the MnSOD expression faster than AgNPs.
      Therefore, it is suggested that AgNO3 has greater penetrability and
      effectiveness.

PMID- 29845082
TI  - Presence of Recombinant Strain of Cucurbit Aphid Borne Yellows Virus in Iran.
AB  - Background:Cucurbit aphid-borne yellows virus (CABYV) is among the most important
      yellowing viruses on cucurbits in Iran. The presence of CABYV has been previously
      reported from the major cucurbit growing areas in Iran, however, there are few
      studies concerning the detection of the different strains of this virus in the
      grower's fields, and especially, there is no report of the weed host plants near
      crop fields. Objectives: This study was done in order to detect the new strains
      of the CABYV polerovirus in cucurbits and the weed plants in the Lorestan
      province, Iran, as an introductory investigation for initiating a program of the
      breeding for resistance. Material and Methods: During a survey carried out in
      2013-2014 in Lorestan province; Iran, 189 cucurbit and 261 weed samples were
      investigated for the presence of CABYV using RT-PCR. In addition, the phylogeny
      and nucleotide similarities were discussed on the basis of the partial nucleotide
      sequence of RNA dependent RNA polymerase (RdRP) gene. Results: The RT-PCR carried
      out on leaf samples revealed the infection with the CABYV in 43 cucumber and 12
      weed samples. RT-PCR using strain specific primers detected the presence of the
      both common (C) and recombinant (R) strains of CABYV in the tested samples. On
      the basis of the phylogenetic analyses, the CABYV-C isolates from Iran were
      clustered into two distinct sub-populations (CI and CII), such that all the weed
      samples with two sequenced cucumber isolates were clustered in the CI sub
      population. Meanwhile, a distinct sub-population of the isolates was clustered in
      the CABYV-R group showed a shared sequence identity of 97% to a Taiwanese isolate
      (JQ700306). Conclusions: This study has indicated the incidence of CABYV-R in the
      Southwest Asia; Iran for the first time. We were also able to show CABYV
      occurrence in Sysimbrium irio and Citrullus colocynthis from this area of the
      world. Identification of cucurbit infecting viruses and studying their
      distribution and potential reservoir hosts are important for developing
      successful control programs for virus disease management.

PMID- 29845083
TI  - Glenohumeral Internal Rotation Deficit and Injuries: A Systematic Review and Meta
      analysis.
AB  - Background: There is an association between throwing activity and glenohumeral
      internal rotation deficit (GIRD). An 18 degrees  to 20 degrees  deficit has been
      adopted as the standard definition of pathological GIRD, but specific findings as
      to how GIRD relates to an injury are inconsistent. Purpose: To systematically
      review the literature to clarify the definition of GIRD diagnosis for adolescent
      and adult overhead athletes and to examine the association between GIRD and an
      increased risk of injuries in these athletes. Study Design: Systematic review;
      Level of evidence, 4. Methods: A systematic review of the literature was
      performed. Observational studies comparing glenohumeral internal rotation range
      of motion (ROM) in injured and uninjured overhead athletes were included for the
      meta-analysis. Studies of adolescent and adult athletes were analyzed separately.
      ROM was compared for the injured and uninjured groups, and a weighted mean GIRD
      was estimated. To account for potential heterogeneity across studies, both fixed-
      and random-effects models were used to calculate a standardized mean difference
      (SMD). Results: Nine studies of level 3 or 4 evidence were included. From these,
      12 study groups (4 adolescent, 8 adult) comprising 819 overhead athletes (226
      injured, 593 uninjured) were included in the meta-analysis. The estimated SMD in
      GIRD between the injured and uninjured groups was 0.46 (95% CI, 0.15-0.77; P <
      .01) for the overall sample. The between-group effect was larger for adults (SMD,
      0.60 [95% CI, 0.18 to 1.02]; P < .01) than adolescents (SMD, 0.20 [95% CI, -0.24
      to 0.63]; P = .13). The weighted mean GIRD for the injured and uninjured groups
      was 13.8 degrees  +/- 5.6 degrees  and 9.6 degrees  +/- 3.0 degrees ,
      respectively, which also differed by age group. Moderate study heterogeneity was
      observed (I2 = 69.0%). Conclusion: Based on this systematic review, the current
      definition of pathological GIRD may be too conservative, and a distinct
      definition may be required for adolescent and adult athletes. While the results
      indicate a link between internal rotation deficits and upper extremity injuries
      in the overhead athlete, higher quality prospective research is needed to clarify
      the role that GIRD plays in future injuries to overhead athletes of various ages.

PMID- 29845084
TI  - Knotless Fixation Is Stronger and Less Variable Than Knotted Constructs in
      Securing a Suture Loop.
AB  - Background: Historically, tendon-to-bone fixation has relied on knot tying.
      However, considerable variability exists in knot-tying strength among surgeons.
      Purpose/Hypothesis: The purpose of this study was to compare the biomechanical
      properties of knotted and knotless fixation and to evaluate variability among
      surgeons. The hypothesis was that knotless constructs would be stronger and have
      less variability as compared with knotted constructs. Study Design: Controlled
      laboratory study. Methods: A total of 34 orthopaedic surgeons participated in a
      laboratory study to compare knotted and knotless constructs, where 104 knotted
      constructs were performed with No. 2 suture, 21 knotless constructs with No. 2
      suture (K2 group), and 79 knotless constructs with suture tape (KT group).
      Mechanical testing was performed to compare load at 3 mm of displacement, load to
      failure, and stiffness of each construct. Results: The mean load at 3 mm of
      displacement was greatest in the KT group, with significant differences among all
      3 groups (P < .001). Load to failure was significantly greater in the KT group as
      compared with the K2 group and the knotted group (P < .001), but there was no
      difference between the K2 and knotted groups (P >= .999). Stiffness and
      displacement were also greatest in the KT group. Based on the F test, the
      variance in load to failure was significantly different between the knotted and
      knotless constructs, with the knotted group demonstrating greater variability
      (SD, 94 N) than the KT (SD, 38 N) and K2 (SD, 17 N) groups (P < .001).
      Conclusion: Knotless fixation with suture tape had improved biomechanical
      performance as compared with knots or knotless fixation with No. 2 suture. In
      addition, knotless fixation had less variability in biomechanical properties
      among multiple surgeons. Clinical Relevance: This study may be relevant for
      surgeons choosing between knotted and knotless constructs as well as for
      considerations in the design of rotator cuff repair constructs.

PMID- 29845085
TI  - Can Weakness in End-Range Plantar Flexion After Achilles Tendon Repair Be
      Prevented?
AB  - Background: Disproportionate end-range plantar flexion weakness, decreased
      passive stiffness, and inability to perform a heel rise on a decline after
      Achilles tendon repair are thought to reflect increased tendon compliance or
      tendon lengthening. Since this was first noted, we have performed stronger
      repairs and avoided stretching into dorsiflexion for the first 12 weeks after
      surgery. Hypothesis: Using stronger repairs and avoiding stretching into
      dorsiflexion would eliminate end-range plantar flexion weakness and normalize
      passive stiffness. Study Design: Case series; Level of evidence, 4. Methods:
      Achilles repairs with epitendinous augmentation were performed on 18 patients.
      Plantar flexion torque, dorsiflexion range of motion (ROM), passive joint
      stiffness, and standing single-legged heel rise on a decline were assessed at 43
      +/- 24 months after surgery (range, 9 months to 8 years). Maximum isometric
      plantar flexion torque was measured at 20 degrees  and 10 degrees  of
      dorsiflexion, neutral position, and 10 degrees  and 20 degrees  of plantar
      flexion. Passive dorsiflexion ROM was measured with a goniometer. Passive joint
      stiffness was computed from the increase in passive torque from 10 degrees  to 20
      degrees  of dorsiflexion. Tendon thickness was measured by use of digital
      calipers. Plantar flexion electromyographic (EMG) data were recorded during
      strength and functional tests. Analysis of variance and chi-square tests were
      used to assess weakness and function. Results: Marked weakness was evident on the
      involved side at 20 degrees  of plantar flexion (deficit, 26% +/- 18%; P < .001),
      with no weakness at 20 degrees  of dorsiflexion (deficit, 6% +/- 17%; P = .390).
      Dorsiflexion ROM was decreased 5.5 degrees  +/- 8 degrees  (P = .015), and tendon
      width was 8 +/- 3 mm greater on the involved side (P < .001). Passive joint
      stiffness was similar between the involved and noninvolved sides. Only 2 of 18
      patients could perform a decline heel rise on the involved side compared with 18
      of 18 on the noninvolved side (P = .01). No difference in EMG amplitude was found
      between the involved and noninvolved sides during the strength or heel rise
      tests. Conclusion: The use of stronger repair techniques and attempts to limit
      tendon elongation by avoiding dorsiflexion stretching did not eliminate weakness
      in end-range plantar flexion. EMG data confirmed that end-range weakness was not
      due to neural inhibition. Physiological changes that alter the force transmission
      capability of the healing tendon may be responsible for this continued
      impairment. This weakness has implications for high-demand jumping and sprinting
      after Achilles tendon repair.

PMID- 29845086
TI  - Vitamin D Insufficiency Among Professional Basketball Players: A Relationship to
      Fracture Risk and Athletic Performance.
AB  - Background: Vitamin D is believed to play a role in influencing fracture risk and
      athletic performance. Insufficiency of vitamin D affects an estimated three
      quarters of the United States population. Hypovitaminosis D has also been
      demonstrated to be quite common among professional basketball players in the
      National Basketball Association (NBA). Purpose: To determine whether a
      relationship exists between vitamin D levels and fracture risk and athletic
      performance (as measured by NBA draft status) among elite basketball players.
      Study Design: Descriptive epidemiology study. Methods: Data were obtained from
      the NBA regarding combine participants from 2009 through 2013. This information
      included vitamin D level, demographic information, fracture history, and NBA
      draft status. The data were analyzed to determine associations between vitamin D
      level and fracture risk and NBA draft status. Results: Vitamin D levels were
      measured for 279 players at the NBA Combine from 2009 through 2013. Vitamin D
      deficiency (<20 ng/mL) was seen in 32.3% of athletes, vitamin D insufficiency (20
      30 ng/mL) was seen in 41.2%, and sufficient levels of vitamin D (>30 ng/mL) were
      present in only 26.5%. A total of 118 players had a history of at least 1
      fracture. Vitamin D level was not predictive of fracture risk. Contrary to our
      hypothesis, players with a history of stress fracture had a significantly greater
      mean vitamin D level than those without such history (30.7 vs 25.1 ng/mL; P =
      .04). A majority (79.6%) of participants were selected in the NBA draft. Players
      with deficient vitamin D levels had a significantly lower rate of being drafted
      into the NBA (P = .027). The NBA draft rate was found to increase with increasing
      levels of vitamin D (P = .007). Conclusion: Hypovitaminosis D is quite common
      among NBA Combine participants, affecting 73.5%. While no significant
      relationship was found between vitamin D level and fracture history, patients
      with a history of stress fracture had significantly greater mean vitamin D
      levels. Additionally, participants with greater vitamin D levels were more likely
      to be drafted into the NBA. This information supports the potential role of
      vitamin D in influencing athletic performance.

PMID- 29845087
TI  - Evaluating motion processing algorithms for use with functional near-infrared
      spectroscopy data from young children.
AB  - Motion artifacts are often a significant component of the measured signal in
      functional near-infrared spectroscopy (fNIRS) experiments. A variety of methods
      have been proposed to address this issue, including principal components analysis
      (PCA), correlation-based signal improvement (CBSI), wavelet filtering, and spline
      interpolation. The efficacy of these techniques has been compared using simulated
      data; however, our understanding of how these techniques fare when dealing with
      task-based cognitive data is limited. Brigadoi et al. compared motion correction
      techniques in a sample of adult data measured during a simple cognitive task.
      Wavelet filtering showed the most promise as an optimal technique for motion
      correction. Given that fNIRS is often used with infants and young children, it is
      critical to evaluate the effectiveness of motion correction techniques directly
      with data from these age groups. This study addresses that problem by evaluating
      motion correction algorithms implemented in HomER2. The efficacy of each
      technique was compared quantitatively using objective metrics related to the
      physiological properties of the hemodynamic response. Results showed that
      targeted PCA (tPCA), spline, and CBSI retained a higher number of trials. These
      techniques also performed well in direct head-to-head comparisons with the other
      approaches using quantitative metrics. The CBSI method corrected many of the
      artifacts present in our data; however, this approach produced sometimes unstable
      HRFs. The targeted PCA and spline methods proved to be the most robust,
      performing well across all comparison metrics. When compared head to head, tPCA
      consistently outperformed spline. We conclude, therefore, that tPCA is an
      effective technique for correcting motion artifacts in fNIRS data from young
      children.

PMID- 29845088
TI  - Theoretical analysis of low-power fast optogenetic control of firing of Chronos
      expressing neurons.
AB  - A detailed theoretical analysis of low-power, fast optogenetic control of firing
      of Chronos-expressing neurons has been presented. A three-state model for the
      Chronos photocycle has been formulated and incorporated in a fast-spiking
      interneuron circuit model. The effect of excitation wavelength, pulse irradiance,
      pulse width, and pulse frequency has been studied in detail and compared with
      ChR2. Theoretical simulations are in excellent agreement with recently reported
      experimental results and bring out additional interesting features. At very low
      irradiances ([Formula: see text]), the plateau current in Chronos exhibits a
      maximum. At [Formula: see text], the plateau current is 2 orders of magnitude
      smaller and saturates at longer pulse widths ([Formula: see text]) compared to
      ChR2 ([Formula: see text]). [Formula: see text] in Chronos saturates at much
      shorter pulse widths (1775 pA at 1.5 ms and [Formula: see text]) than in ChR2.
      Spiking fidelity is also higher at lower irradiances and longer pulse widths
      compared to ChR2. Chronos exhibits an average maximal driven rate of over
      [Formula: see text] in response to [Formula: see text] stimuli, each of 1-ms
      pulse-width, in the intensity range 0 to [Formula: see text]. The analysis is
      important to not only understand the photodynamics of Chronos and Chronos
      expressing neurons but also to design opsins with optimized properties and
      perform precision experiments with required spatiotemporal resolution.

PMID- 29845089
TI  - Special Section Guest Editorial: Technology Platforms for Treatment and Discovery
      in Human Systems: Novel Work in Image-Guided Procedures, Robotic Interventions,
      and Modeling.
AB  - This guest editorial introduces the Special Section on Image-Guided Procedures,
      Robotic Interventions, and Modeling in JMI Vol. 5 Issue 2.

PMID- 29845090
TI  - Detection of small traumatic hemorrhages using a computer-generated average human
      brain CT.
AB  - Computed tomography is a standard diagnostic imaging technique for patients with
      traumatic brain injury (TBI). A limitation is the poor-to-moderate sensitivity
      for small traumatic hemorrhages. A pilot study using an automatic method to
      detect hemorrhages [Formula: see text] in diameter in patients with TBI is
      presented. We have created an average image from 30 normal noncontrast CT scans
      that were automatically aligned using deformable image registration as
      implemented in Elastix software. Subsequently, the average image was aligned to
      the scans of TBI patients, and the hemorrhages were detected by a voxelwise
      subtraction of the average image from the CT scans of nine TBI patients. An
      experienced neuroradiologist and a radiologist in training assessed the presence
      of hemorrhages in the final images and determined the false positives and false
      negatives. The 9 CT scans contained 67 small haemorrhages, of which 97% was
      correctly detected by our system. The neuroradiologist detected three false
      positives, and the radiologist in training found two false positives. For one
      patient, our method showed a hemorrhagic contusion that was originally missed.
      Comparing individual CT scans with a computed average may assist the physicians
      in detecting small traumatic hemorrhages in patients with TBI.

PMID- 29845091
TI  - Positron emission tomography-based assessment of metabolic gradient and other
      prognostic features in sarcoma.
AB  - Intratumoral heterogeneity biomarkers derived from positron emission tomography
      (PET) imaging with fluorodeoxyglucose (FDG) are of interest for a number of
      cancers, including sarcoma. A range of radiomic texture variables, adapted from
      general methodologies for image analysis, has shown promise in the setting. In
      the context of sarcoma, our group introduced an alternative model-based approach
      to the measurement of heterogeneity. In this approach, the heterogeneity of a
      tumor is characterized by the extent to which the 3-D FDG uptake pattern deviates
      from a simple elliptically contoured structure. By using a nonparametric analysis
      of the uptake profile obtained from this spatial model, a variable assessing the
      metabolic gradient of the tumor is developed. The work explores the prognostic
      potential of this new variable in the context of FDG-PET imaging of sarcoma. A
      mature clinical series involving 197 patients, 88 of whom have complete time-to
      death information, is used. Texture variables based on the imaging data are also
      evaluated in this series and a range of appropriate machine learning
      methodologies are then used to explore the complementary prognostic roles for
      structure and texture variables. We conclude that both texture-based and model
      based variables can be combined to achieve enhanced prognostic assessments of
      outcome for patients with sarcoma based on FDG-PET imaging information.

PMID- 29845092
TI  - Symptomatic muscular sarcoidosis: Lessons from a nationwide multicenter study.
AB  - Objectives: To describe clinicopathologic features of muscular sarcoidosis and
      the associated sarcoidosis phenotype through a nationwide multicenter study.
      Methods: Patients were included if they had histologically proven sarcoidosis and
      symptomatic muscular involvement confirmed by biological, imaging, or histologic
      examinations. Results: Forty-eight patients (20 males) were studied, with a
      median age at muscular symptoms onset of 45 years (range 18-71). Four patterns
      were identified: a nodular pattern (27%); smoldering phenotype (29%); acute,
      subacute, or progressive myopathic type (35%); and combined myopathic and
      neurogenic pattern (10%). In all patterns, sarcoidosis was multivisceral with a
      median of 3 extramuscular organs involved (mostly lungs, lymph nodes, eyes, and
      skin) and a prolonged course with long-term use of corticosteroids and
      immunosuppressive drugs. Muscular patterns differed according to clinical
      presentation (myalgia, nodules, or weakness), electromyographic findings,
      muscular MRI, and response to sarcoidosis treatment. The myopathic and
      neuromuscular patterns were more severe. Conclusion: This nationwide study of
      muscular sarcoidosis allowed the identification of 4 patterns of granulomatous
      myositis, which differed by phenotypes and the clinical course.

PMID- 29845093
TI  - Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in
      human study.
AB  - Objective: To determine whether autologous infusions of expanded regulatory T
      lymphoctyes (Tregs) into patients with amyotrophic lateral sclerosis (ALS) are
      safe and tolerable during early and later stages of disease. Methods: Three
      patients with ALS, with no family history of ALS, were selected based on their
      differing sites of disease onset and rates of progression. Patients underwent
      leukapheresis, and Tregs were subsequently isolated and expanded ex vivo. Tregs
      (1 * 106 cells/kg) were administered IV at early stages (4 doses over 2 months)
      and later stages (4 doses over 4 months) of disease. Concomitant interleukin-2 (2
      * 105 IU/m2/injection) was administered subcutaneously 3 times weekly over the
      entire study period. Patients were closely monitored for adverse effects and
      changes in disease progression rates. Treg numbers and suppressive function were
      assayed during and following each round of Treg infusions. Results: Infusions of
      Tregs were safe and well tolerated in all patients. Treg numbers and suppressive
      function increased after each infusion. The infusions slowed progression rates
      during early and later stages of disease. Spearman correlation analyses showed
      that increased Treg suppressive function correlated with slowing of disease
      progression per the Appel ALS scale for each patient: patient 1: rho (rho) = 
      0.60, p = 0.003; patient 2: rho = -0.71, p = 0.0026; and patient 3: rho = -0.54,
      p = 0.016. Measures of maximal inspiratory pressure also stabilized, particularly
      in 2 patients, during Treg infusions. Conclusions: These results demonstrate the
      safety and potential benefit of expanded autologous Treg infusions, warranting
      further clinical trials in patients with ALS. The correlation between Treg
      suppressive function and disease progression underscores the significance of
      using Treg suppressive function as an indicator of clinical status.
      Classification of evidence: This study provides Class IV evidence. This is a
      phase I trial with no controls.

PMID- 29845094
TI  - Long-read transcriptome data for improved gene prediction in Lentinula edodes.
AB  - Lentinula edodes is one of the most popular edible mushrooms in the world and
      contains useful medicinal components such as lentinan. The whole-genome sequence
      of L. edodes has been determined with the objective of discovering candidate
      genes associated with agronomic traits, but experimental verification of gene
      models with correction of gene prediction errors is lacking. To improve the
      accuracy of gene prediction, we produced 12.6 Gb of long-read transcriptome data
      of variable lengths using PacBio single-molecule real-time (SMRT) sequencing and
      generated 36,946 transcript clusters with an average length of 2.2 kb. Evidence
      driven gene prediction on the basis of long- and short-read RNA sequencing data
      was performed; a total of 16,610 protein-coding genes were predicted with error
      correction. Of the predicted genes, 42.2% were verified to be covered by full
      length transcript clusters. The raw reads have been deposited in the NCBI SRA
      database under accession number PRJNA396788.

PMID- 29845095
TI  - A data-based study in support of Blackbuck related cases from Haryana.
AB  - Haryana State (located in the northern part of India), is lacking in natural
      forest, but it has rich biodiversity of some wild animals, especially the
      Blackbuck antelopes. The maximum population of Blackbucks in the state is living
      in open cultivated fields. Blackbucks were once found abundantly throughout
      Haryana, but now they are limited to the south-west part of the state, driven
      almost to extinction in the rest of Haryana, mainly because of habitat
      destruction and wildlife crime. This data report is an outcome of six years
      (January 2012-September 2017), based on assessment of records in terms of
      location, year and month wise frequency of death and rescued cases related to
      Blackbuck reported, as registered by the State Wildlife Department. It is
      envisioned that this data report will provide appropriate information for the
      conservationist to plan future conservation strategy for Blackbucks in Haryana.

PMID- 29845096
TI  - Nano-cellulose biopolymer based nano-biofilm biomaterial using plant biomass: An
      innovative plant biomaterial dataset.
AB  - The nano-cellulose derived nano-biofilm keeps a magnificent role in medical,
      biomedical, bioengineering and pharmaceutical industries. Plant biomaterial is
      naturally organic and biodegradable. This study has been highlighted as one of
      the strategy introducing biomass based nano-bioplastic (nanobiofilm) to solve
      dependency on petroleum and environment pollution because of non-degradable
      plastic. The data study was carried out to investigate the nano-biopolymer
      (nanocellulose) based nano-biofilm data from corn leaf biomass coming after
      bioprocess technology without chemicals. Corn leaf biomass was used to produce
      biodegradable nano-bioplastic for medical and biomedical and other industrial
      uses. Data on water absorption, odor, pH, cellulose content, shape and firmness,
      color coating and tensile strength test have been exhibited under standardization
      of ASTM (American standard for testing and materials). Moreover, the chemical
      elements of nanobiofilm like K+, CO3--, Cl-, Na+ showed standard data using the
      EN (166).

PMID- 29845097
TI  - Data on functional characterization of LECT2 from Lampetra japonica.
AB  - The data presented in this article are related to the research article entitled
      "Characterization of the LECT2 gene and its protective effects against microbial
      infection via large lymphocytes in Lampetra japonica" (Wang et al., 2017) [1].
      Here, we presented new original data about the effect of rL-LECT2 on cancer cells
      migration and macrophages phagocytosis. Wound healing assay and transwell
      chemotaxis assays were used to measure rL-LECT2 inhibition rates on cancer cell
      migration. Additionally, fluospheres beads and Escherichia coli-FITC were used to
      measure whether the rL-LECT2 can affect the phagocytosis of RAW264.7 cells.

PMID- 29845098
TI  - Data of optimization of laccase production by Marasmiellus palmivorus LA1 under
      solid state fermentation using one factor at a time method.
AB  - This article contains data regarding optimization of laccase production under
      solid state fermentation by the basidiomycetes fungi Marasmiellus palmivorus
      LA1.The data was collected by varying one factor at a time and keeping other
      factors of the system constant. Influence of environmental factors (substrate
      type, temperature, inoculums size, substrate weight, substrate length, pH),
      nutritional factors (organic and inorganic nitrogen sources, carbon sources,
      surfactants) and elicitors added to media was examined through the laccase
      activity of the extract. Specific activity at every stage was also measured. The
      data presents an opportunity to compare the relative influential role of each of
      the contributing factors on laccase production and directly relates to our
      research article "Optimization of laccase production from M. palmivorus LA1 by
      Taguchi method of design of experiments" (Chenthamarakshan et al., 2017 [1]).

PMID- 29845099
TI  - Structural changes of Chlamydomonas reinhardtii cells during lipid enrichment and
      after solvent exposure.
AB  - Data are related to Confocal Laser Scanning Microscopy (CLSM) observations of
      lipid-enriched Chlamydomonas reinhardtii cells under different conditions.
      Firstly, the impact of stress conditions (nitrogen starvation) on the cell wall
      structure is assessed. Secondly is described the effect of solvents, in the
      context of lipid extraction, on the microalga's cell, particularly its lipid
      droplets, in the perspective of understanding the mechanisms behind solvent
      extraction of lipids. Furthermore, the role of the cell wall as a barrier to the
      solvent extraction action is highlighted.

PMID- 29845100
TI  - Data on a new sensitivity-improved miniaturized label-free electrochemical
      biosensor.
AB  - This article presents a new sensitivity-improved electrochemical measurement
      architecture for cardiovascular disease (CVD) diagnosis by detecting CVD
      biomarkers, S100 beta protein and C-reactive protein (CRP). The new architecture
      includes a design for a new electrochemical measurement set-up, which improves
      the reaction conditions of chemical and biological molecules and incorporates a
      newly biochip design. With the new architecture, electrochemical measurement
      experiments were undertaken. The results obtained are related to the research
      article entitled "Improving sensitivity of a miniaturized label-free
      electrochemical biosensor using zigzag electrodes" [1].

PMID- 29845101
TI  - Mapping Anopheles stephensi midgut proteome using high-resolution mass
      spectrometry.
AB  - Anopheles stephensi Liston is one of the major vectors of malaria in urban areas
      of India. Midgut plays a central role in the vector life cycle and transmission
      of malaria. Because gene expression of An. stephensi midgut has not been
      investigated at protein level, an unbiased mass spectrometry-based proteomic
      analysis of midgut tissue was carried out. Midgut tissue proteins from female An.
      stephensi mosquitoes were extracted using 0.5% SDS and digested with trypsin
      using two complementary approaches, in-gel and in-solution digestion. Fractions
      were analysed on high-resolution mass spectrometer, which resulted in acquisition
      of 494,960 MS/MS spectra. The MS/MS spectra were searched against protein
      database comprising of known and predicted proteins reported in An. stephensi
      using Sequest and Mascot software. In all, 47,438 peptides were identified
      corresponding to 5,709 An. stephensi proteins. The identified proteins were
      functionally categorized based on their cellular localization, biological
      processes and molecular functions using Gene Ontology (GO) annotation. Several
      proteins identified in this data are known to mediate the interaction of the
      Plasmodium with vector midgut and also regulate parasite maturation inside the
      vector host. This study provides information about the protein composition in
      midgut tissue of female An. stephensi, which would be useful in understanding
      vector parasite interaction at molecular level and besides being useful in
      devising malaria transmission blocking strategies. The data of this study is
      related to the research article "Integrating transcriptomics and proteomics data
      for accurate assembly and annotation of genomes".

PMID- 29845102
TI  - Tumor lysis syndrome associated with docetaxel and carboplatin in a case with
      recurrent endometrial cancer.
AB  - Tumor lysis syndrome (TLS) is an oncological life-threatening complication
      characterized by hyperuricemia, hyperphosphatemia, and hyperkalemia, which can
      lead to acute renal failure, cardiac arrhythmias, cardiac arrest and seizures.
      Although TLS is a rare complication in patients with non-hematological
      malignancy, the mortality rate of TLS in solid tumors is higher than that in
      hematological malignancies. Acute renal injury is the most common cause of
      mortality associated with TLS in solid tumors. We report a case of TLS following
      chemotherapy for a recurrent uterine serous carcinoma. In this case, we
      speculated that the cause of death might be a pulmonary tumor embolism caused by
      TLS.

PMID- 29845103
TI  - Using gene expression in patients with endometrial intraepithelial neoplasia to
      assess the risk of cancer.
AB  - Patients diagnosed with an endometrial cancer precursor lesion on biopsy may be
      found to have endometrial cancer at the time of subsequent surgery. The current
      study seeks to identify patients with endometrial intraepithelial neoplasia (EIN)
      on biopsy that may be harboring an occult carcinoma. Immunohistochemical stains
      for gene loss of expression (LOE) for 6 genes, PTEN, ARID1A, MSH6, MSH2, MLH1,
      and PMS2, were performed on 113 biopsy specimens with EIN. For the 95 patients
      with follow-up histology, 40 patients had cancer, 41 had EIN, and 14 had normal
      endometrium. PTEN LOE was found frequently in both EIN and endometrial cancer,
      and therefore had low positive predictive value. All specimens with ARID1A, MSH6,
      MSH2, MLH1, or PMS2 LOE on biopsy were subsequently found to have cancer. LOE of
      any gene was associated with modest sensitivity (0.78) in identifying patients
      with endometrial cancer who had EIN on biopsy. Further investigation is warranted
      to determine if gene LOE is a useful clinical tool when evaluating patients with
      EIN on biopsy.

PMID- 29845104
TI  - Oncofertility in the setting of advanced cervical cancer - A case report.
AB  - Objective: To consider fertility options in women with advanced cervical cancer.
      Design: Case report. Setting: Large tertiary care center. Patient: A 30-year-old
      nulligravida woman diagnosed with FIGO Stage IBI squamous cell carcinoma of the
      cervix that had metastasized to a pelvic lymph node. Interventions: Robotic
      radical trachelectomy with pelvic lymphadenectomy and cerclage placement,
      followed by ovarian stimulation with oocyte retrieval and in vitro fertilization.
      Subsequent therapy included adjuvant chemoradiation and embryo transfer to a
      surrogate mother. Main outcome measures: Cervical cancer remission, live birth
      from surrogate pregnancy. Results: 33-year-old woman in her third year of
      remission from advanced cervical cancer with healthy twin girls. Conclusions:
      Fertility options may exist for patients even in the setting of metastatic
      cervical cancer. Early involvement of a reproductive endocrinologist is
      imperative. This case emphasizes the importance of cross-specialty communication.

PMID- 29845105
TI  - Serotonin Selectively Increases Detectability of Motion Stimuli in the
      Electrosensory System.
AB  - Serotonergic innervation of sensory areas is found ubiquitously across the
      central nervous system of vertebrates. Here, we used a system's level approach to
      investigate the role of serotonin on processing motion stimuli in the
      electrosensory system of the weakly electric fish Apteronotus albifrons. We found
      that exogenous serotonin application increased the firing activity of pyramidal
      neural responses to both looming and receding motion. Separating spikes belonging
      to bursts from those that were isolated revealed that this effect was primarily
      due to increased burst firing. Moreover, when investigating whether firing
      activity during stimulation could be discriminated from baseline (i.e., in the
      absence of stimulation), we found that serotonin increased stimulus
      discriminability only for some stimuli. This is because increased burst firing
      was most prominent for these. Further, the effects of serotonin were highly
      heterogeneous, with some neurons displaying large while others instead displaying
      minimal changes in responsiveness following serotonin application. Further
      analysis revealed that serotonin application had the greatest effect on neurons
      with low baseline firing rates and little to no effect on neurons with high
      baseline firing rates. Finally, the effects of serotonin on sensory neuron
      responses were largely independent of object velocity. Our results therefore
      reveal a novel function for the serotonergic system in selectively enhancing
      discriminability for motion stimuli.

PMID- 29845106
TI  - Perceptual Oscillation of Audiovisual Time Simultaneity.
AB  - Action and perception are tightly coupled systems requiring coordination and
      synchronization over time. How the brain achieves synchronization is still a
      matter of debate, but recent experiments suggest that brain oscillations may play
      an important role in this process. Brain oscillations have been also proposed to
      be fundamental in determining time perception. Here, we had subjects perform an
      audiovisual temporal order judgment task to investigate the fine dynamics of
      temporal bias and sensitivity before and after the execution of voluntary hand
      movement (button-press). The reported order of the audiovisual sequence was
      rhythmically biased as a function of delay from hand action execution.
      Importantly, we found that it oscillated at a theta range frequency, starting
      ~500 ms before and persisting ~250 ms after the button-press, with consistent
      phase-locking across participants. Our results show that the perception of cross
      sensory simultaneity oscillates rhythmically in synchrony with the programming
      phase of a voluntary action, demonstrating a link between action preparation and
      bias in temporal perceptual judgments.

PMID- 29845107
TI  - Dbx1 Pre-Botzinger Complex Interneurons Comprise the Core Inspiratory Oscillator
      for Breathing in Unanesthetized Adult Mice.
AB  - The brainstem pre-Botzinger complex (preBotC) generates inspiratory breathing
      rhythms, but which neurons comprise its rhythmogenic core? Dbx1-derived neurons
      may play the preeminent role in rhythm generation, an idea well founded at
      perinatal stages of development but incompletely evaluated in adulthood. We
      expressed archaerhodopsin or channelrhodopsin in Dbx1 preBotC neurons in intact
      adult mice to interrogate their function. Prolonged photoinhibition slowed down
      or stopped breathing, whereas prolonged photostimulation sped up breathing. Brief
      inspiratory-phase photoinhibition evoked the next breath earlier than expected,
      whereas brief expiratory-phase photoinhibition delayed the subsequent breath.
      Conversely, brief inspiratory-phase photostimulation increased inspiratory
      duration and delayed the subsequent breath, whereas brief expiratory-phase
      photostimulation evoked the next breath earlier than expected. Because they
      govern the frequency and precise timing of breaths in awake adult mice with
      sensorimotor feedback intact, Dbx1 preBotC neurons constitute an essential core
      component of the inspiratory oscillator, knowledge directly relevant to human
      health and physiology.

PMID- 29845108
TI  - Changes in Parkinson's disease sleep symptoms and daytime somnolence after
      bilateral subthalamic deep brain stimulation in Parkinson's disease.
AB  - INTRODUCTION: Deep brain stimulation (DBS) markedly improves motor function in
      advanced Parkinson's disease (PD), but its effect on sleep is less clear.
      PATIENTS AND METHODS: Forty PD patients who had subthalamic DBS (STN-DBS) were
      identified from an on-going non-motor naturalistic longitudinal study (NILS). All
      patients were followed up for at least 6 months, 26 patients had a 1 year follow
      up. A total PDSS score of 100 or less, a score in any PDSS-item of 6 or less, and
      a Epworth score of 10 or more were classified as being significant. RESULTS:
      Forty-five percent of patients reported significant improvement in the total PDSS
      score at 6 months, and 35% at 12 months. In terms of magnitude, the total PDSS
      score at 6 months was significantly improved from baseline while the improvement
      at 12 months was not statistically significant. The most frequently reported
      improvements were overall sleep quality and maintenance of sleep. Some patients
      reported worsening of the total PDSS score. More than half of the patients
      reporting daytime sleepiness at baseline had persistent sleepiness at 6 and 12
      months. The mean Epworth Score did not improve because a significant number of
      patients without sleepiness at baseline reported new-onset sleepiness at 6 and 12
      months. Neither medication changes nor motor improvement were consistently
      related to sleep changes after DBS. CONCLUSION: Subthalamic DBS is associated
      with a statistically and clinically significant, but variable, improvement in
      sleep as measured by the PDSS. The most frequent improvements were better overall
      sleep quality and better sleep maintenance.

PMID- 29845109
TI  - Simulated microgravity attenuates myogenic differentiation via epigenetic
      regulations.
AB  - The molecular mechanisms involved in myogenic differentiation are relatively well
      known. Myogenic differentiation is regulated by the sequential activation of the
      basic helix-loop-helix myogenic regulatory transcription factors (MRFs), and
      biomechanical signals play an important role in the regulation of myogenesis. In
      this study, we sought to determine whether simulated microgravity culture using
      Gravite(r) may affect myoblast differentiation and expression of MRF genes.
      Although rat myoblasts, L6 cells were differentiated to myotubes in an incubation
      period-dependent manner, myogenesis of L6 cells was significantly attenuated
      under simulated microgravity (10-3G) conditions. Real-time Reverse transcription
      polymerase chain reaction (RT-PCR) showed that expressions of Myog, Myf6, Mef2c,
      Des, and Ckm under 1 G conditions increase in an incubation period-dependent
      manner, and that Myod1 expression was specifically observed to increase
      transiently in the early phase. However, expressions of Myod1 and Myog were
      significantly inhibited under simulated microgravity conditions. To clarify the
      molecular mechanisms, L6 cells were treated with 5-AzaC, and further incubated
      with differentiation medium under 1 G or 10-3 G conditions. The results showed
      differences in expression levels of Myod1, Myog, and, as well as those of myotube
      thickness between 1 G and 10-3 G conditions, completely disappeared in this
      experimental condition. Modified HpaII tiny fragment enrichment by ligation
      mediated PCR (HELP)-assay showed that kinetic changes of DNA methylation status
      were attenuated in simulated microgravity conditions. These results indicate that
      microgravity regulates myogenesis and Myod1 expression by controlling DNA
      methylation.

PMID- 29845110
TI  - Prognostic gene expression assays in breast cancer: are two better than one?

PMID- 29845111
TI  - The PROMISe to increase precision in adjuvant therapy for early breast cancer: To
      "Type" or to "Print"?

PMID- 29845112
TI  - ANXA11 mutations prevail in Chinese ALS patients with and without cognitive
      dementia.
AB  - Objective: To investigate the genetic contribution of ANXA11, a gene associated
      with amyotrophic lateral sclerosis (ALS), in Chinese ALS patients with and
      without cognitive dementia. Methods: Sequencing all the coding exons of ANXA11
      and intron-exon boundaries in 18 familial amyotrophic lateral sclerosis (FALS),
      353 unrelated sporadic amyotrophic lateral sclerosis (SALS), and 12 Chinese
      patients with ALS-frontotemporal lobar dementia (ALS-FTD). The transcripts in
      peripheral blood generated from a splicing mutation were examined by reverse
      transcriptase PCR. Results: We identified 6 nonsynonymous heterozygous mutations
      (5 novel and 1 recurrent), 1 splice site mutation, and 1 deletion of 10 amino
      acids (not accounted in the mutant frequency) in 11 unrelated patients,
      accounting for a mutant frequency of 5.6% (1/18) in FALS, 2.3% (8/353) in SALS,
      and 8.3% (1/12) in ALS-FTD. The deletion of 10 amino acids was detected in 1
      clinically undetermined male with an ALS family history who had atrophy in hand
      muscles and myotonic discharges revealed by EMG. The novel p. P36R mutation was
      identified in 1 FALS index, 1 patient with SALS, and 1 ALS-FTD. The splicing
      mutation (c.174-2A>G) caused in-frame skipping of the entire exon 6. The rest
      missense mutations including p.D40G, p.V128M, p.S229R, p.R302C and p.G491R were
      found in 6 unrelated patients with SALS. Conclusions: The ANXA11 gene is one of
      the most frequently mutated genes in Chinese patients with SALS. A canonical
      splice site mutation leading to skipping of the entire exon 6 further supports
      the loss-of-function mechanism. In addition, the study findings further expand
      the ANXA11 phenotype, first highlighting its pathogenic role in ALS-FTD.

PMID- 29845114
TI  - Chorea-acanthocytosis: Homozygous 1-kb deletion in VPS13A detected by whole
      genome sequencing.
AB  - Objective: To determine a molecular diagnosis for a large multigenerational
      family of South Asian ancestry with seizures, hyperactivity, and episodes of
      tongue biting. Methods: Two affected individuals from the family were analyzed by
      whole-genome sequencing on the Illumina HiSeq X platform, and rare variants were
      prioritized for interpretation with respect to the phenotype. Results: A
      previously undescribed, 1-kb homozygous deletion was identified in both
      individuals sequenced, which spanned 2 exons of the VPS13A gene, and was found to
      segregate in other family members. Conclusions: VPS13A is associated with
      autosomal recessive chorea-acanthocytosis, a diagnosis consistent with the
      phenotype observed in this family. Whole-genome sequencing presents a
      comprehensive and agnostic approach for detecting diagnostic mutations in
      families with rare neurologic disorders.

PMID- 29845113
TI  - Determining the incidence of familiality in ALS: A study of temporal trends in
      Ireland from 1994 to 2016.
AB  - Objective: To assess temporal trends in familial amyotrophic lateral sclerosis
      (FALS) incidence rates in an Irish population and to determine factors
      influencing FALS ascertainment. Methods: Population-based data collected over 23
      years, using the Irish amyotrophic lateral sclerosis (ALS) register and DNA
      biobank, were analyzed and age-standardized rates of FALS and associated familial
      neuropsychiatric endophenotypes were identified. Results: Between 1994 and 2016,
      269 patients with a family history of ALS from 197 unique families were included
      on the register. Using stringent diagnostic criteria for FALS, the mean age
      standardized FALS incidence rate for the study period was 11.1% (95% confidence
      interval [CI], 8.8-13.4). The FALS incidence rate increased steadily from 5.2% in
      1994 to 19.1% in 2016, an annual increase of 0.7% (95% CI, 0.5-0.9, p < 0.0001).
      Inclusion of the presence of neuropsychiatric endophenotypes within kindreds
      increased the FALS incidence rate to 30%. The incidence of FALS in newly
      diagnosed individuals from known families increased significantly with time,
      accounting for 50% of all FALS diagnoses by 2016. The mean annual rate of
      recategorization from "sporadic ALS" to "FALS" was 3% (95% CI, 2.6-3.8).
      Conclusions: The true population-based rate of FALS is at least 20%. Inclusion of
      extended endophenotypes within kindreds increases the rate of FALS to 30%. Cross
      sectional analysis of clinic-based cohorts and stringent definitions of FALS
      underestimate the true rate of familial disease. This has implications for
      genetic counseling and in the recognition of presymptomatic stages of ALS.

PMID- 29845115
TI  - Brain copper storage after genetic long-term correction in a mouse model of
      Wilson disease.

PMID- 29845116
TI  - Case Report: Laparoscopic Approach for Orchiopexy in a 26-Year-Old Man with
      Accidentally Discovered Persistent Mullerian Duct Syndrome and Bilateral
      Undescended Testis.
AB  - Background: Persistent Mullerian duct syndrome (PMDS) is not a common form of
      disorder of sex development in which Mullerian duct derivatives (fallopian tubes,
      uterus, and the proximal vagina) are present in an otherwise normally
      differentiated 46 XY male. In most of cases, the challenge comes in the procedure
      of orchiopexy. Case Presentation: We report a case of a 26-year-old man with
      PMDS. It was accidentally discovered when the patient presented to our outpatient
      clinic concerning about his empty scrotum as a premarital check. Diagnostic
      laparoscopy discovered Mullerian remnants in the form of uterus, cervix, and
      fallopian tubes with two attached testes to the fallopian tubes. Staged
      laparoscopic orchiopexy was done. We discuss the presentation, the management of
      this case in the literature, and our intervention. Conclusion: PMDS is not a
      common condition. Several concerns present in the management of these cases.
      Malignant transformation of the testis is the main risk facing those patients.
      Few literature studies discussed the risk of changing of these remnants into
      malignant tissue. Thus discussion with the patient, tissue histopathology, expert
      opinions, and literature review are the main clues in management of such cases.

PMID- 29845117
TI  - Ureteral Obstruction Secondary to an Appendiceal Mucocele: A Case Report and
      Literature Review.
AB  - Background: Ureteral obstruction is rarely caused by extrinsic compression from
      the appendix. In addition, mucinous neoplasms of the appendix are rare, found
      incidentally in 0.2%-0.7% of appendectomy specimens. Case Presentation: We
      present an unusual case of ureteral obstruction caused by a large appendiceal
      mucocele. An asymptomatic 53-year-old caucasian male patient, known for recurrent
      nephrolithiasis, was referred for management of bilateral nephrolithiasis. A
      noncontrast CT scan found an atrophic kidney with an obstructive 1.8 cm right
      midureteral stone above a 9 * 4.3 cm appendiceal mucocele compressing the right
      midureter. Although the impacted ureteral stone was extracted with retrograde
      ureteroscopy and holmium laser lithotripsy, the appendiceal mucocele was resected
      by laparoscopic appendectomy. Final pathology analysis revealed an unperforated
      low-grade appendiceal mucinous neoplasm of 13 cm without lymphovascular invasion.
      Since the whole mucocele was completely excised, it did not require any further
      follow-up. Postoperative CT scan demonstrated stone-free status on the right side
      with residual mild right hydroureteronephrosis. A diuretic renal scintigraphy
      showed a nonobstructed right kidney with a chronically dilated pelvicaliceal
      system and a 34% differential function in the right kidney. Follow-up for up to 2
      years postoperatively demonstrated that his diuretic renal scan did not show
      deterioration of the differential renal function, indicating that there was no
      significant obstruction. Conclusion: This is the fourth reported case of
      appendiceal mucocele causing extrinsic ureteral obstruction, and the secondary
      urinary stasis contributed to formation of a large midureteral stone and cortical
      renal atrophy. This case demonstrates the importance of the work-up and
      management of obstructive ureteral stones before definitive management of
      appendiceal mucoceles.

PMID- 29845118
TI  - Resident and Program Director's Perceptions of Milestone-Based Feedback in
      Obstetrics and Gynecology.
AB  - Introduction: In July 2014, US residency programs fully implemented the Next
      Accreditation System including the use of milestone evaluation and reporting.
      Currently, there has been little investigation into the result of implementation
      of this new system. Therefore, this study sought to evaluate perceptions of
      Obstetrics and Gynecology residents and program directors regarding the use of
      milestone-based feedback and identify areas of deficiency. Methods: A Web-based
      survey was sent to US-based Obstetrics and Gynecology residents and program
      directors regarding milestone-based assessment implementation. Results: Out of
      245 program directors, 84 responded to our survey (34.3% response rate). Of
      responding program directors, most reported that milestone-based feedback was
      useful (74.7%), fair (83.0%), and accurate (76.5%); however, they found it
      administratively burdensome (78.1%). Residents felt that milestone-based feedback
      was useful (62.7%) and fair (70.0%). About 64.3% of residents and 74.7% of
      program directors stated that milestone-based feedback is an effective tool to
      track resident progression; however, a sizable minority of both groups believe
      that it does not capture surgical aptitude. Qualitative analysis of free response
      comments was largely negative and highlighted the administrative burden and lack
      of accuracy of milestone-based feedback. Conclution: Overall, both Obstetrics and
      Gynecology program directors and residents report that milestone-based feedback
      is useful and fair. Issues of administrative burden, timeliness, evaluation of
      surgical aptitude, and ability to act on assigned milestone levels were
      identified. Although this study is limited to one specialty, such issues are
      likely important to all residents, faculty, and program directors who have
      implemented the Next Accreditation System requirements.

PMID- 29845119
TI  - Applying Metacognition Through Patient Encounters and Illness Scripts to Create a
      Conceptual Framework for Basic Science Integration, Storage, and Retrieval.
AB  - Problem: Medical school curriculum continues to search for methods to develop a
      conceptual educational framework that promotes the storage, retrieval, transfer,
      and application of basic science to the human experience. To achieve this goal,
      we propose a metacognitive approach that integrates basic science with the
      humanistic and health system aspects of medical education. Intervention: During
      the week, via problem-based learning and lectures, first-year medical students
      were taught the basic science underlying a disease. Each Friday, a patient with
      the disease spoke to the class. Students then wrote illness scripts, which
      required them to metacognitively reflect not only on disease pathophysiology,
      complications, and treatments but also on the humanistic and health system issues
      revealed during the patient encounter. Evaluation of the intervention was
      conducted by measuring results on course exams and national board exams and
      analyzing free responses on the illness scripts and student course feedback. The
      course exams and National Board of Medical Examiners questions were divided into
      3 categories: content covered in lecture, problem-based learning, or patient +
      illness script. Comparisons were made using Student t-test. Free responses were
      inductively analyzed using grounded theory methodology. Context: This curricular
      intervention was implemented during the first 13-week basic science course of
      medical school. The main objective of the course, Scientific Principles of
      Medicine, is to lay the scientific foundation for subsequent organ system
      courses. A total of 150 students were enrolled each year. We evaluated this
      intervention over 2 years, totaling 300 students. Outcome: Students scored
      significantly higher on illness script content compared to lecture content on the
      course exams (mean difference = 11.1, P = .006) and national board exams given in
      December (mean difference = 21.8, P = .0002) and June (mean difference = 12.7, P
      = .016). Themes extracted from students' free responses included the following:
      relevance of basic science, humanistic themes of empathy, resilience, and the
      doctor-patient relationship, and systems themes of cost, barriers to care, and
      support systems. Lessons learned: A metacognitive approach to learning through
      the use of patient encounters and illness script reflections creates stronger
      conceptual frameworks for students to integrate, store, retain, and retrieve
      knowledge.

PMID- 29845120
TI  - Successful Endovascular Therapy in an Elderly Patient with Severe Hemorrhage
      Caused by Traumatic Injury.
AB  - An 85-year-old female suffered pelvic fracture, multiple rib fractures, right
      hemopneumothorax, and blunt abdominal aortic injury in a traffic accident. After
      transfer to our hospital, transcatheter arterial embolization (TAE) was performed
      immediately for hemorrhage from the bilateral internal iliac arteries. Enhanced
      computed tomography (CT) after TAE showed an increase of hematoma and
      extravasation at the bifurcation of the abdominal aorta. Therefore, emergency
      abdominal endovascular aortic repair was performed on the same day. On the 3rd
      day after transfer, metabolic acidosis worsened suddenly, and enhanced CT
      revealed intestinal necrosis. Emergency surgery for the intestinal necrosis was
      performed. The patient was transferred to the previous hospital on the 31st day
      after transfer. Endovascular treatment is useful for elderly patients with severe
      trauma. However, the preservation and/or reconstruction of the blood flow to
      important organs should be monitored.

PMID- 29845121
TI  - Inflammatory Biomarkers and Risk of Atherosclerotic Cardiovascular Disease.
AB  - Background: Non-alcoholic fatty liver disease is an increasing health issue that
      associates with the development of atherosclerotic cardiovascular disease. This
      study correlates the association between fatty liver and inflammatory biomarkers
      with cardiovascular risk scores. Methodology: This cross-sectional study enrolled
      10,181 health examination participants from Northern Taiwan and administered a
      standardized questionnaire with important biochemical tests and abdominal
      sonography. To assess concentrations of inflammatory markers high sensitivity C
      reactive protein (hs-CRP) and fibrinogen were used. Results: Inflammatory marker
      levels were significantly increased with increasing fatty liver. In multivariate
      logistic regression analysis adjusted for major confounding factors, the odds
      ratios of elevated hs-CRP and fibrinogen were significantly higher in
      participants with mild or moderate-to-severe fatty liver compared to healthy
      individuals. The cardiovascular risk scores, above cut-off level 10%, were
      associated with higher levels of inflammatory biomarkers and fatty liver; odds
      ratio, 3.52 (2.60-4.77) for non-alcoholic fatty liver disease with hs-CRP, and
      2.92 (2.12-4.00) for non-alcoholic fatty liver disease with fibrinogen.
      Conclusion: Inflammatory biomarkers (hs-CRP and fibrinogen) are significantly
      associated with augmentation of fatty liver. Non-alcoholic fatty liver disease
      may be a predictor of future atherosclerotic cardiovascular disease, and the
      prediction value increases on adding inflammatory biomarkers levels.

PMID- 29845122
TI  - Growth Suppression of Glioma Cells Using HDAC6 Inhibitor, Tubacin.
AB  - In cancer research, autophagy has been revealed as one of the major ways to
      maintain the metabolism of cancer cells, including glioma cells, through protein
      degradation. Meanwhile, autophagy is also regarded as a kind of mechanism to
      protect glioma cells from a harmful stimulus, such as chemical and radiation
      treatment. So, the inhibition of autophagy may be very helpful in curing glioma.
      This study aimed to determine the effect of autophagic inhibition on glioma cells
      using tubacin, a specific inhibitor of histone deacetylase 6(HDAC6). According to
      the results, tubacin inhibited the growth of both U251 and LN229 cells, which was
      accompanied by lower HDAC6 activity and accumulated autophagosome. The inhibition
      of HDCA6 also led to accumulation of autophagosome and death of glioma cells.
      Moreover, the combined treatment of tubacin and temozolomide, an alkylating agent
      used to treat glioblastoma, induced more severe glioma cell death. Thus, it can
      be concluded that inhibition of HDAC6 suppressed growth and drug resistance of
      glioma cells in-vitro through autophagic suppression and blocking of fusion of
      autophagosome and lysosome.

PMID- 29845123
TI  - Highly-efficient and low-temperature perovskite solar cells by employing a Bi
      hole transport layer consisting of vanadium oxide and copper phthalocyanine.
AB  - In this article, an inorganic-organic bilayer hole transport layer (B-HTL) is
      designed and utilized in planar perovskite solar cells. Here the B-HTL consists
      of an inorganic VOx matrix and a copper phthalocyanine (CuPc) buffer layer,
      providing excellent resistance to moisture as well as the alignment of the
      interfacial energy level. Benefiting from this typical HTL, an enlarged built-in
      potential and charge extraction can be achieved in PSCs simultaneously.
      Correspondingly, a champion device with a B-HTL shows a 16.85% efficiency with
      negligible hysteresis, which is superior to that of a PSC based on a PEDOT:PSS
      HTL. Meanwhile, significantly prolonged stability of the PSC with the B-HTL can
      be observed, exhibiting only a 10% efficiency loss after 350 hours in ambient
      air. Moreover, such an entirely low-temperature (<=60  degrees C) fabrication
      process of this typical PSC exhibits its successful application in flexible
      devices.

PMID- 29845124
TI  - Catalytic enantioselective aldol reactions.
AB  - Recent developments in catalytic asymmetric aldol reactions have been summarized.
      Enantioselective aldol reactions are important methods to synthesize beta-hydroxy
      carbonyl compounds in optical pure form, and as such, numerous successful chiral
      catalysts were designed and applied for asymmetric aldol reactions. This review
      article is organized under the categories of: (1) catalytic enantioselective
      aldol reactions of preformed enolates, (2) catalytic enantioselective direct-type
      aldol reactions using chiral metal catalysts, (3) catalytic enantioselective
      direct-type aldol reactions using organocatalysts, (4) catalytic enantioselective
      aldol reactions in aqueous media. Examples of the aldol reactions that employ
      simple carbonyl compounds will be also the focus of this review.

PMID- 29845125
TI  - Time-dependent yield of the hydrated electron and the hydroxyl radical in D2O: a
      picosecond pulse radiolysis study.
AB  - Picosecond pulse radiolysis measurements were performed in neat D2O and H2O in
      order to study the isotopic effect on the time-resolved yield of the hydrated
      electron and hydroxyl radical. First, the absorption band of the hydrated
      electron in D2O, eD2O-, is measured between 250 and 1500 nm. The molar absorption
      coefficient of the solvated electron spectrum in D2O was determined using the
      isosbestic point method by scavenging the solvated electron using methyl
      viologen. The amplitude and shape of the absorption spectrum of the hydrated
      electron in D2O are different from those previously reported in the literature.
      The maximum of the hydrated electron in the D2O absorption band is ca. 704 nm
      with a molar absorption coefficient of (22 900 +/- 500) L mol-1 cm-1. Based on
      this extinction coefficient, the radiolytic yield of eD2O- just after the 7 ps
      electron pulse was determined to be (4.4 +/- 0.2) * 10-7 mol J-1, which coincides
      with the one for eH2O- in H2O. The time-dependent radiolytic yield of eD2O- was
      determined from a few ps to 8 ns. To determine the OD radical yield, the
      contribution of the solvated electron and of the transient species produced by
      the electron pulse in the windows of the fused silica optical cell was taken into
      account for the analysis of the transient absorption measurements at 260 nm.
      Therefore, an appropriate experimental methodology is used for measuring low
      absorbance at two different wavelengths in ps pulse radiolysis. The yield of the
      OD radical just after the 7 ps electron pulse was found to be (5.0 +/- 0.2) * 10
      7 mol J-1. In the spurs of ionization, the decay rate of eD2O- is slower than
      eH2O-, whereas the decay rate of OD is similar to the one of OH. Here, the
      established time-dependent yield of the solvated electron and the hydroxyl
      radical provide the foundation for improving the models used for spur reaction
      simulations in heavy water mainly for the chemistry of CANDU reactors.

PMID- 29845126
TI  - Insight into the electronic and mechanical properties of novel TMCrSi ternary
      silicides from first-principles calculations.
AB  - Transition metal silicides (TMSis) are attractive advanced functional materials
      due to their low electronic resistivity, high melting-point, excellent mechanical
      properties and thermal stability. However, the overall performances of binary
      silicides are not satisfactory enough to meet the requirements of many commercial
      applications. To overcome this problem, utilizing ternary silicide is a good path
      to adjust the balance between the overall performances because metallic bond
      plays a key role in electronic properties. The TM-Si bond enhances the strength,
      while the alloying element (Cr) can effectively improve the oxidation and
      corrosion resistances. Therefore, we report the results of electronic, mechanical
      and thermodynamic properties of stable TMCrSi ternary silicides by using first
      principles calculations. First, we found that TMCrSi ternary silicides are
      dynamically stable based on the phonon dispersion curves. Second, the constructed
      ternary silicides exhibit better electronic properties because of the formation
      of TM-Cr metallic bond. Importantly, these ternary silicides not only show high
      strength, but also have better ductility. Additionally, the Debye temperature and
      heat capacity of TMCrSi ternary silicides are discussed. Finally, through our
      study, we propose that TMCrSi ternary silicides are promising functional
      materials with potential applications in aerospace, microelectronic and energy
      storage systems.

PMID- 29845127
TI  - Gd-DTPA-coupled Ag2Se quantum dots for dual-modality magnetic resonance imaging
      and fluorescence imaging in the second near-infrared window.
AB  - Near-infrared (NIR) fluorescent quantum dots (QDs) are ideal platforms to
      fabricate multifunctional contrast agents for multimodal imaging. Herein, second
      near-infrared window fluorescent (NIR-II) Ag2Se QDs were coupled with
      gadopentetate dimeglumine injection (Gd-DTPA) for dual-modality T1-weighted
      magnetic resonance (MR) imaging and fluorescence imaging. In vitro experiments
      suggested that the prepared Ag2Se-Gd QDs exhibit low cytotoxicity, remarkable T1
      weighted MR imaging, and fluorescence imaging contrast properties. In vivo
      experiment results showed that Ag2Se-Gd QDs were the preferred contrast agents
      for dual-modality T1-weighted MR imaging and fluorescence imaging with high
      spatial resolution. Moreover, excellent temporal resolution and high tissue
      penetration depth were also achieved by fluorescence imaging. These results
      indicate the potential of Ag2Se-Gd QDs as multifunctional contrast agents for
      multimodal imaging in clinical diagnosis and research.

PMID- 29845128
TI  - Active fluids at circular boundaries: swim pressure and anomalous droplet
      ripening.
AB  - We investigate the swim pressure exerted by non-chiral and chiral active
      particles on convex or concave circular boundaries. Active particles are modeled
      as non-interacting and non-aligning self-propelled Brownian particles. The convex
      and concave circular boundaries are used to model a fixed inclusion immersed in
      an active bath and a cavity (or container) enclosing the active particles,
      respectively. We first present a detailed analysis of the role of convex versus
      concave boundary curvature and of the chirality of active particles in their
      spatial distribution, chirality-induced currents, and the swim pressure they
      exert on the bounding surfaces. The results will then be used to predict the
      mechanical equilibria of suspended fluid enclosures (generically referred to as
      'droplets') in a bulk with active particles being present either inside the bulk
      fluid or within the suspended droplets. We show that, while droplets containing
      active particles behave in accordance with standard capillary paradigms when
      suspended in a normal bulk, those containing a normal fluid exhibit anomalous
      behaviors when suspended in an active bulk. In the latter case, the excess swim
      pressure results in non-monotonic dependence of the inside droplet pressure on
      the droplet radius; hence, revealing an anomalous regime of behavior beyond a
      threshold radius, in which the inside droplet pressure increases upon increasing
      the droplet size. Furthermore, for two interconnected droplets, mechanical
      equilibrium can occur also when the droplets have different sizes. We thus
      identify a regime of anomalous droplet ripening, where two unequal-sized droplets
      can reach a final state of equal size upon interconnection, in stark contrast
      with the standard Ostwald ripening phenomenon, implying shrinkage of the smaller
      droplet in favor of the larger one.

PMID- 29845129
TI  - Selective CO2 adsorption by a new metal-organic framework: synergy between open
      metal sites and a charged imidazolinium backbone.
AB  - Metal-organic frameworks (MOFs) are porous, tunable crystalline materials that
      are attracting widespread scientific attention for their potential use in post
      combustion CO2 capture. In this work, we report the synthesis of a new ligand,
      1,3-bis(4-carboxyphenyl)-4,5-dihydro-1H-imidazol-3-ium tetrafluoroborate, H2Sp5
      BF4, that is subsequently used for the construction of a novel MOF, Cu-Sp5-EtOH.
      This highly crystalline material has a charged framework that is expected to give
      rise to high CO2/N2 selectivity. However, the pores of the parent structure could
      not be accessed due to the presence of strongly coordinated ethanol molecules.
      After solvent exchange with methanol and subsequently heating Cu-Sp5-MeOH under
      vacuum, we are able to liberate the solvent providing other small molecules like
      CO2 access to the inside of the now porous structure, Cu-Sp5. The combination of
      open metal sites and framework charge leads to an exceptionally high CO2/N2
      selectivity, as determined by Ideal Adsorbed Solution Theory (IAST) calculations
      performed on single-component adsorption isotherms. The CO2/N2 selectivity of Cu
      Sp5 reaches a value of over 200 at pressures typically found in post-combustion
      flue gas (0.15 bar CO2/0.85 bar N2), a value that is among the highest reported
      to date.

PMID- 29845130
TI  - Membrane potential and dynamics in a ternary lipid mixture: insights from
      molecular dynamics simulations.
AB  - Transmembrane potential (Vm) plays critical roles in cell signaling and other
      functions. However, the impact of Vm on the structure and dynamics of membrane
      lipids and proteins, which are critical for the regulation of signaling, is still
      an open question. All-atom molecular dynamics (MD) simulation is emerging as a
      useful technique to address this issue. Previous atomistic MD simulations of pure
      or binary model membranes indicated that both ion imbalance and electric field
      can be used to generate Vm, but both approaches failed to yield structural
      changes in lipids with statistical significance. We hypothesized that a possible
      reason for this could be oversimplified membrane composition or limited sampling.
      In this work, we tested if and how Vm modulates the structure and dynamics of
      lipids in a physiologically relevant model membrane. Using a detailed side-by
      side comparison, we first show that while both ion imbalance and electric field
      generate Vm in our complex membranes, only the latter could produce
      physiologically relevant Vm. We further show that double bonds in lipid acyl
      chains have a relatively large sensitivity to Vm. A single-bilayer model with an
      electric field showed the highest sensitivity in simulations under the isothermal
      isobaric (NPT) ensemble, reproducing expected responses of head-group dipoles to
      Vm and suggesting that this approach may be more suitable for studying the
      structural effects of Vm. Our findings also shed light on the relationship
      between the macroscopic Vm and its atomic-level underpinnings.

PMID- 29845131
TI  - Probing the structural, electronic and magnetic properties of AgnSc (n = 1-16)
      clusters.
AB  - The structural, electronic and magnetic properties of AgnSc (n = 1-16) clusters
      have been studied on the basis of density functional theory and the CALYPSO
      structure prediction method. The optimized geometry exhibits that the growth
      process of Sc-doped silver clusters have a periodic structural change. The Ag
      atom grows around a basically invariant cluster core in each growth cycle. The Sc
      atom has a tendency to occupy the most highly coordinated position in the ground
      state. The infrared spectra, Raman spectra and photoelectron spectra of AgnSc
      clusters are forecasted and can be used to identify the structures of these
      clusters from experiments. The global maxima of the dissociation energy, the
      averaged binding energy and the gap of the energy level occur at n = 15 for the
      most stable AgnSc clusters, implying that the Ag15Sc can be perceived as a
      superatom. The magnetism analysis indicates that the magnetic moment of the Sc
      atom in AgnSc clusters decreases with the increase of the cluster. The change of
      the magnetic moment is proportional to the charge transfer between the Sc and Ag
      atoms.

PMID- 29845132
TI  - 808 nm-light-excited upconversion nanoprobe based on LRET for the ratiometric
      detection of nitric oxide in living cancer cells.
AB  - NO (nitric oxide) has dual functions in cancer, promoting carcinogenesis in low
      concentrations and inducing tumor cell apoptosis at high concentrations. The dual
      edged-sword functions of NO make it particularly appealing to develop a sensitive
      and specific chemical probe for its detection. However, most NO sensors suffer
      from poor Stokes shifts and are limited by ultraviolet (UV) or visible light
      excitation, which render it difficult to avoid the intrinsic background signal.
      In this study, an 808 nm laser-excited Nd3+-sensitized upconversion nanoprobe
      based on LRET (luminescence resonance energy-transfer) for NO detection was
      constructed for the first time. This probe was composed of Nd3+-sensitized core
      shell upconversion nanoparticles (540 nm and 660 nm emission) as the energy donor
      and RhBs as the acceptor. In the presence of NO, RhBs was converted into
      Rhodamine B and its strong absorption subsequently quenched the 540 nm
      fluorescence of UCNPs, while the emission at 660 nm remained constant. The
      ratiometric detection of the fluorescence at 540 nm, as compared to 660 nm, can
      precisely respond to the difference in NO levels with a detection limit of 0.21
      MUM. Importantly, compared with conventional UCNPs excited at 980 nm, the 808 nm
      light excitation led to lower water absorption and deeper tissue penetration,
      thus avoiding overheating and allowing for long-term biological imaging. This
      strategy has been perfectly applied to detecting the NO levels in living cells to
      differentiate the tumor cells from normal cells based on varied intracellular NO
      concentration. Further, the nanosystem realized the real-time monitoring of NO
      during treatment with NO donor drugs, which could inspire the future application
      of this probe to guide NO therapy.

PMID- 29845133
TI  - Chemical Leslie effect in Langmuir monolayers: a complete experimental
      characterization.
AB  - We propose a complete characterization of the chemical Leslie effect in a
      Langmuir monolayer of a chiral liquid crystal. To reach this goal, we developed
      new experimental techniques using an electric field and a humidifier to prepare
      large monodomains in which the molecules can freely rotate. We also designed six
      independent experiments to precisely measure the four material constants involved
      in the dynamics of the monolayer, namely the Leslie coefficient, the rotational
      viscosity, the curvature elasticity constant and the surface polarization. The
      relevance of the inverse Leslie effect is also discussed.

PMID- 29845134
TI  - A general strategy for the functionalization of two-dimensional metal
      chalcogenides.
AB  - Two-dimensional (2D) metal chalcogenides (MC) such as MoS2 have been recognized
      as promising materials for near future applications. However, general strategies
      to functionalize them are still scarce, while the nature of functionalization
      still remains unclear. Herein, we demonstrate a simple and universal
      functionalization route through complexation reaction between the amino
      containing organic agents and MCs. Degrees of functionalization are tunable by
      adjusting the organic group types and ratios. No further defects are introduced
      and the functionalized 2D MCs are dispersible in corresponding typical solvents.
      Both experimental results and geometry optimization calculations indicate that
      the grafting of functional groups through the coordination effect truly exist,
      while the surface properties and resulting photoelectric properties of 2D MCs are
      greatly altered. More intriguingly, our proposed functionalization process is
      demonstrated to be universal and can be applied to different MCs, thus opening
      new avenues for the application of 2D MCs.

PMID- 29845135
TI  - Spin crossover dynamics studies on the thermally activated molecular oxygen
      binding mechanism on a model copper complex.
AB  - The theoretical description of the primary dioxygen (O2) binding and activation
      step in many copper or iron enzymes, suffers from the intrinsically electronic
      non-adiabaticity of the spin flip events of the triplet dioxygen molecule (3O2),
      mediated by spin-orbit couplings. In this work, we presented the early-stage
      ultrafast spin flip dynamics of O2 binding for a simplified monocopper complex,
      involving the coupled singlet and triplet electronic states. The on-the-fly
      trajectory surface hopping (TSH) simulations have identified the dynamical
      effects that may influence the mode of O2 coordination (end-on vs. side-on), and
      the electronic structures can be viewed as complexes of molecular O2 with Cu(i)
      or as Cu(ii)-superoxide compounds. In addition, significant spin flip events are
      obversed within the sub-picosecond regime. We hope this work may provide
      complimentary insights on the traditional interpretation of O2 binding on copper
      complexes and subsequent catalytic reaction mechanisms.

PMID- 29845136
TI  - Dissipative assemblies that inhibit their deactivation.
AB  - Dissipative self-assembly is a process in which energy-consuming chemical
      reaction networks drive the assembly of molecules. Prominent examples from
      biology include the GTP-fueled microtubule and ATP-driven actin assembly. Pattern
      formation and oscillatory behavior are some of the unique properties of the
      emerging assemblies. While artificial counterparts exist, researchers have not
      observed such complex responses. One reason for the missing complexity is the
      lack of feedback mechanisms of the assemblies on their chemical reaction network.
      In this work, we describe the dissipative self-assembly of colloids that protect
      the hydrolysis of their building blocks. The mechanism of inhibition is
      generalized and explored for other building blocks. We show that we can tune the
      level of inhibition by the assemblies. Finally, we show that the robustness of
      the assemblies towards starvation is affected by the degree of inhibition.

PMID- 29845138
TI  - Defect mediated magnetic transitions in Fe and Mn doped MoS2.
AB  - We report single-phase syntheses of undoped 2H-MoS2 as well as Mn and Fe doped
      MoS2 by a facile hydrothermal route. The formation of the 2H-MoS2 phase was
      confirmed by XRD and was corroborated with Raman spectra. The morphology of the
      doped and undoped MoS2 nanostructures comprised sheets, as revealed by TEM and
      STEM images. The fine granular structure was observed by high resolution TEM
      micrographs. The STEM-EDS results show dopant concentrations of ~1 atom%
      corresponding to Mn and Fe in doped MoS2. The undoped MoS2 revealed diamagnetic
      behavior at room temperature and paramagnetic behavior in the range (100 to 300
      K). The Mn-MoS2 sample displayed ferromagnetism below 20 K with a coercive field
      of ~50 Oe. Such a sample may be utilized for magnetic switching purposes at low
      temperatures. The onset of the antiferromagnetic interaction was observed below
      145 K in Fe-MoS2 samples. They have been understood in terms of long-range
      magnetic interactions amongst the dipole moments mediated via surface defects as
      well as the interaction between the dipoles and the surface charges. The findings
      are corroborated with the help of EPR studies.

PMID- 29845137
TI  - Cetuximab and Taxol co-modified collagen scaffolds show combination effects for
      the repair of acute spinal cord injury.
AB  - Injury-activated endogenous neural stem cells (NSCs) in the spinal cord have
      promising therapeutic applications for rebuilding the neuronal relays after
      spinal cord injury (SCI) because of their lack of immune-rejection following
      exogenous cell transplantation. However, these NSCs rarely differentiate into
      neurons and the damaged axonal regenerative ability is drastically reduced due to
      the adverse SCI microenvironment. Cetuximab, an EGFR signaling antagonist, has
      demonstrated the ability of promoting NSC differentiation into neurons. Taxol, in
      addition to stabilizing microtubules, has shown potential for enhancing axonal
      regeneration and reducing scar formation after SCI. In this study, we further
      verified the combined therapeutic effects of Cetuximab and Taxol on inhibition of
      scar deposition and promotion of neuronal differentiation, axonal outgrowth and
      functional recovery in a rat severe SCI model. A linear orderly collagen scaffold
      modified with Cetuximab and Taxol was grafted into the SCI site after the
      complete removal of 4 mm of spinal tissue. The results showed that the combined
      functional scaffold implantation significantly increased neural regeneration to
      reconnect the neural network. Moreover, scaffold transplantation decreases the
      deposition of varied scar-related inhibitors within the lesion center, further
      reflecting the need for a combination dedicated to increasing motor function
      following SCI. Collagen scaffold based-combined therapy provides a potential
      strategy for improving functional restoration of the injured spinal cord.

PMID- 29845139
TI  - Field dependence of the ferromagnetic/superconducting proximity effect in a
      YBCO/STO/LCMO multilayer.
AB  - The interaction between superconductivity and magnetism in spatially confined
      heterostructures of thin film multilayers is investigated in the ferromagnetic
      manganite La2/3Ca1/3MnO3 (LCMO) and the high-temperature superconductor YBa2Cu3O7
      delta (YBCO) mediated by an intermediate insulating SrTiO3 (STO) layer. The STO
      layer is used to mediate and tune the range of interactions between the
      ferromagnet and superconductor. A magnetically depleted layer with zero
      magnetisation within the LCMO layer is shown by polarised neutron reflectometry
      measurements. This zero-magnetisation layer is caused by the onset of
      superconductivity in YBCO despite being separated by an insulating layer with a
      thickness much larger than the superconducting coherence length. The magnetic
      field dependence of this interaction is also explored. We show that the magnetism
      of the depleted layer can be restored by applying a magnetic field that partially
      destroys the superconductivity in YBCO, restricting the electronic interaction
      between the materials.

PMID- 29845140
TI  - Controllable oligomerization: defying step-growth kinetics in the polymerization
      of gold nanoparticles.
AB  - Random aggregation of nanoparticles typically leads to step-growth kinetics and
      thus a low concentration of dimers. Here, we report a one-step method to produce
      gold nanoparticle dimers by exploiting a polystyrene-block-poly (acrylic acid)
      shell. Methods to fine-tune the surface charge repulsion and swelling allow us to
      control the extent of aggregation, stopping selectively at dimers.

PMID- 29845141
TI  - Competition between salt bridge and non-zwitterionic structures in deprotonated
      amino acid dimers.
AB  - Structures of deprotonated Cys, Asp, Glu, Phe, Pro, His homo dimers as well as
      [2Cys - 3H]-, [Asp + Glu - H]- and [2Glu - 2H + Na]- are investigated with
      infrared multiple-photon dissociation (IRMPD) spectroscopy between 650 and 1850
      cm-1 and theory. The IRMPD spectra of all investigated complexes but [2His - H]-,
      [2Phe - H]- and [2Pro - H]- indicate that the structures consist of a neutral non
      zwitterionic (NZ) and a deprotonated form of the amino acids. In contrast, the
      spectrum of [2His - H]- is complex and indicates the presence of multiple isomers
      and/or interactions between His and [His - H]-, so that its structure differs
      from that of the other deprotonated amino acid dimers. For [2Phe - H]- and
      especially for [2Pro - H]-, some IRMPD bands can only be explained by the
      presence of salt bridge (SB) structures in the dimer in which a deprotonated
      amino acid interacts with a zwitterionic neutral amino acid. Computational
      results indicate that SB structures are lower in energy at 298 K than
      corresponding NZ structures for neutral-anion complexes in which SB formation is
      not disrupted by amino acid side chains or conformational constraints, such as in
      [2Glu - H]- and [2Cys - 3H]- for which NZ structures are most consistent with
      experimental results. For deprotonated amino acid dimers in which these
      interfering interactions are absent, such as in [2Phe - H]- and [2Pro - H]-, the
      higher number of hydrogen bonds in SB compared to NZ structures stabilize the
      formation of zwitterionic neutral amino acids and consequently SB structures in
      agreement with results from IRMPD spectroscopy. These results suggest that SB
      structures likely occur in deprotonated peptide or protein ions at hydrophobic
      sites, such as protein-protein interfaces or in the interior of proteins, where
      interfering functional groups will not disrupt SB formation.

PMID- 29845142
TI  - Uniquely integrated Fe-doped Ni(OH)2 nanosheets for highly efficient oxygen and
      hydrogen evolution reactions.
AB  - Developing high-efficiency electrocatalysts for both oxygen evolution reaction
      (OER) and hydrogen evolution reaction (HER) is vital for the production of
      hydrogen on a large scale by electrocatalytic splitting of water. Herein, Fe
      doped Ni(OH)2 nanosheets directly grown on commercial Ni foam (FeNiOH/NF) were
      fabricated through a facile hydrothermal method in (NH4)2S2O8 aqueous solution
      containing iron salts. The integrated architecture with hierarchical pores is
      beneficial for exposing sufficient catalytically active sites and providing
      evaluated structural and electrical properties. In particular, the Fe-induced
      partial-charge-transfer greatly modifies the electronic structure of Ni(OH)2,
      which evidently promotes the electrocatalytic activity of the as-fabricated
      FeNiOH/NF for OER and HER. Thus, as an electrocatalyst for OER, FeNiOH/NF
      exhibits excellent activity with overpotentials of 271 and 318 mV to deliver
      current densities of 20 and 100 mA cm-2, respectively, with a small Tafel slope
      of 72 mV dec-1 in 1.0 M KOH, demonstrating the very high level of novelty and
      sufficient improvement over the current state-of-the-art IrO2 electrocatalyst.
      Most importantly, there is an increase in overpotential by only 23 mV during
      continuous reaction for over 20 h at an applied potential of 1.62 V to deliver
      current density of 500 mA cm-2. The as-fabricated electrocatalyst also enables
      high HER activity with robust stability. Finally, an overall water splitting
      current density of 10 mA cm-2 can be obtained at a cell voltage of 1.67 V in a
      two-electrode alkaline electrolyzer using FeNiOH/NF as both anode and cathode,
      along with impressive operation stability. This development with significant over
      the state-of-the-art IrO2 electrocatalyst can be widely extended to large-scale
      fabrication of versatile electrocatalysts for efficient water splitting
      technology.

PMID- 29845143
TI  - Two-dimensional GeAsSe with high and unidirectional conductivity.
AB  - Prompted by the recent passion for researching two-dimensional materials, we
      investigate again the long-forgotten layered semiconductor material GeAsSe. A
      small cleavage energy (0.18 J m-2) and high thermal stability (1300 K) in
      monolayer structures were proved by employing density functional theory
      calculations. Additionally, the unusual electronic transport behaviors in GeAsSe
      make it more valuable for research. Our investigation proves unidirectional
      electronic transportation in GeAsSe. At room temperature (300 K), the transport
      ability of monolayer GeAsSe in the y direction is about 44 times larger than that
      in the x direction. Furthermore, through layer stacking, the conductivity of
      bilayer GeAsSe is improved to 192 cm2 V-1 s-1 in the y direction which is 200
      times larger than that in the x direction (0.96 cm2 V-1 s-1), implying
      unidirectional conductivity. This work suggests that two-dimensional GeAsSe is a
      promising material for nano-electronic devices.

PMID- 29845144
TI  - Continuous tuneable droplet ejection via pulsed surface acoustic wave jetting.
AB  - We report a miniaturised platform for continuous production of single or multiple
      liquid droplets with diameters between 60 and 500 MUm by interfacing a capillary
      driven self-replenishing liquid feed with pulsed excitation of focussed surface
      acoustic waves (SAWs). The orifice-free operation circumvents the disadvantages
      of conventional jetting systems, which are often prone to clogging that
      eventuates in rapid degradation of the operational performance. Additionally, we
      show the possibility for flexibly tuning the ejected droplet size through the
      pulse width duration, thus avoiding the need for a separate device for every
      different droplet size required, as is the case for systems in which the droplet
      size is set by nozzles and orifices, as well as preceding ultrasonic jetting
      platforms where the droplet size is controlled by the operating frequency.
      Further, we demonstrate that cells can be jetted and hence printed onto
      substrates with control over the cell density within the droplets down to single
      cells. Given that the jetting does not lead to significant loss to the cell's
      viability or ability to proliferate, we envisage that this versatile jetting
      method can potentially be exploited with further development for cell
      encapsulation, dispensing and 3D bioprinting applications.

PMID- 29845146
TI  - Exceptional photoconductivity of poly(3-hexylthiophene) fibers through in situ
      encapsulation of molybdenum disulfide quantum dots.
AB  - Photo-responsive, electrically conductive nanostructures are highly desirable for
      wide-ranging applications in energy harvesting, nanophotonic and optoelectronic
      devices. To this end, we realize self-assembled, photoconductive hybrids of
      poly(3-hexylthiophene) (P3HT) micro- and nano-fibers integrated with MoS2 quantum
      dots (QDs). We present an innovative strategy to impregnate QDs within the walls
      of the P3HT fibers resulting in the emergence of the controllable
      photoconductivity of the QD-P3HT hybrid. The maximum photoconductivity (>80%
      higher than pristine P3HT) is observed at 360 nm and originates from a
      synergistic combination of (a) defect healing and quenching of surface trap
      states in QDs by P3HT and (b) efficient generation and transfer of photo-excited
      charges from P3HT to QDs. This mechanism is substantiated by a concomitant
      decrease in the excited-state lifetime of the QD-P3HT hybrid. Furthermore, a
      linear correlation between the enhancement in the emission of QDs and the
      emission quenching of P3HT supports the proposed mechanism of excited-state
      charge transfer. Finally, the hybrid of MoS2 nanosheets (NS) with P3HT fibers (NS
      P3HT) does not exhibit any photo-conductivity and instead exhibits ground state
      charge transfer, underlying the critical role of quantum confinement effects
      operating in the QD-P3HT hybrid. Thus, we demonstrate a synergistic, self
      assembled QD-P3HT hybrid exhibiting optically controllable electrical
      conductivity in the solid state as novel functional materials for optoelectronic
      applications.

PMID- 29845145
TI  - Use of porous membranes in tissue barrier and co-culture models.
AB  - Porous membranes enable the partitioning of cellular microenvironments in vitro,
      while still allowing physical and biochemical crosstalk between cells, a feature
      that is often necessary for recapitulating physiological functions. This article
      provides an overview of the different membranes used in tissue barrier and
      cellular co-culture models with a focus on experimental design and control of
      these systems. Specifically, we discuss how the structural, mechanical, chemical,
      and even the optical and transport properties of different membranes bestow
      specific advantages and disadvantages through the context of physiological
      relevance. This review also explores how membrane pore properties affect
      perfusion and solute permeability by developing an analytical framework to guide
      the design and use of tissue barrier or co-culture models. Ultimately, this
      review offers insight into the important aspects one must consider when using
      porous membranes in tissue barrier and lab-on-a-chip applications.

PMID- 29845147
TI  - Dietary fatty acid composition impacts plasma fatty acid ethanolamide levels and
      body composition in golden Syrian hamsters.
AB  - Fatty acid ethanolamides (FAEs) are a class of lipid amides that regulate
      numerous pathophysiological functions. To date, pharmacological research in this
      area has focused on the endocannabinoid system, metabolic pathways, and
      biological significance of FAEs; however, limited nutritional studies have been
      conducted to understand the actions of FAEs on food intake and their role on
      overall body composition. Therefore, the present study was designed with the
      hypothesis that high C18:1n9 will attenuate food consumption in golden Syrian
      male hamsters (n = 105). Moreover, the long-term (two months) effects of feeding
      hamsters various dietary oil blends, namely, C+S, 25:75 corn oil:n9 safflower
      oil; F+S, 25:75 flaxseed oil:n6 safflower oil; H+DHA, 85:15 high oleic canola
      oil:docosahexaenoic acid; H+EPA, 85:15 high oleic canola oil:eicosapentaenoic
      acid; HOCO, high oleic canola oil; OO, olive oil; and RC, regular canola oil, on
      the plasma levels of seven different FAEs and fatty acids (FAs) composition were
      investigated. A further objective was to characterize the actions of these diets
      on energy expenditure and overall body composition to determine if dietary fatty
      acid (DFA) composition affects diet-induced obesity (DIO). The results show that
      DFA directly influenced plasma FA and FAE levels, with marked increases (p <
      0.05) observed in plasma C18:1n9 levels after HOCO and OO treatments.
      Correspondingly, the most elevated plasma oleoylethanolamide (OEA) levels were
      observed with HOCO and OO treatments, which also decreased (p < 0.05) food intake
      by ~8% when compared with H+EPA dietary treatment when measured at the endpoint.
      Diminished food intake subsequent to HOCO and OO feeding may have resulted from
      increased OEA concentrations, demonstrating the anorexic properties of the high
      C18:1n9 dietary components. No differences were observed across OO, HOCO, and
      HOCO diets with omega-3 FA blends in terms of body composition, energy
      expenditure, plasma C18:1n9 levels, or OEA concentrations. Based on these
      findings, we conclude that the addition of HOCO to diets aids in the reduction of
      food intake, which may contribute to the maintenance of healthy body weight.

PMID- 29845148
TI  - Syntheses, crystal structures, adsorption properties and visible photocatalytic
      activities of highly stable Pb-based coordination polymers constructed by 2-(2
      carboxyphenyl)imidazo(4,5-f)-(1,10)phenanthroline and bridging linkers.
AB  - Five highly stable coordination polymers assembled by 2-(2
      carboxyphenyl)imidazo(4,5-f)-(1,10)phenanthroline (2-HNCP) and different aromatic
      carboxylic acid ligands, namely, [Pb(2-NCP)(L1)]n (1), [Pb2(2-NCP)2(L2)]n.2nH2O
      (2), [Pb2(2-NCP)2(L2)]n (3), [Pb(2-NCP)(L3)0.5]n (4) and [Pb2(2-NCP)2(L4)]n (5),
      where HL1 = pyridine-4-carboxylic acid, H2L2 = 2-amino-1,4-benzenedicarboxylic
      acid, H2L3 = 1,4-benzenedicarboxylic acid and H2L4 = 2-hydroxy-1,4
      benzenedicarboxylic acid, have been synthesized under hydrothermal conditions.
      Their structures have been determined by single crystal X-ray diffraction
      analyses and further characterized by elemental analyses and infrared
      spectroscopy. In 1, adjacent ladder-like chains are extended into a three
      dimensional (3D) supramolecular architecture by pi-pi interactions. In 2, the
      neighboring layers are interconnected by pi-pi interactions to afford a 3D
      supramolecular architecture. 3-5 exhibit similar 3D frameworks with a Schlafli
      symbol of 412.63 topologies. The different auxiliary ligands and the pH value of
      the reaction system were discussed in regard to the formation of different
      structures. In addition, these five complexes present high thermal stabilities,
      the preferential adsorption of CO2 over N2 and excellent photocatalytic
      activities for dye degradation under visible light irradiation.

PMID- 29845149
TI  - Insight into the effect of intercalated alkaline cations of layered manganese
      oxides on the oxygen reduction reaction and oxygen evolution reaction.
AB  - The effect of the intercalated alkaline cations between the adjacent layers of
      multilayered manganese oxide (MnOx) towards the oxygen reduction reaction (ORR)
      and oxygen evolution reaction (OER) was investigated. Li-MnOx, Na-MnOx, K-MnOx,
      Rb-MnOx, and Cs-MnOx provide OER overpotentials of 1.64, 1.70, 1.79, 1.83, and
      1.84 V vs. RHE, respectively as well as ORR overpotentials of 0.71, 1.06, 1.13,
      1.15, and 1.14 V vs. RHE, respectively. Li-MnOx shows the highest bifunctional
      catalytic activity towards both the ORR and OER. In addition, the Gibbs free
      energy change of *OH adsorption is found to be the largest throughout the
      reaction pathways determining the rate of the whole ORR and OER.

PMID- 29845150
TI  - A hierarchical flower-like hollow alumina supported bimetallic AuPd nanoparticle
      catalyst for enhanced solvent-free ethylbenzene oxidation.
AB  - Currently, oxidation of alkylaromatics is considered as one of the most crucial
      chemical technologies to produce high added-value alcohols, ketones and
      carboxylic acids, due to its significant importance both in fine synthetic
      chemistry and in the academic field. In this work, a novel hierarchical marigold
      like hollow alumina supported bimetallic AuPd nanoparticle catalyst was
      successfully fabricated and employed for highly efficient solvent-free
      ethylbenzene oxidation to produce acetophenone with the coexistence of both
      molecular oxygen and tert-butyl hydroperoxide as the oxidant and the initiator.
      The as-fabricated bimetallic AuPd nanocatalyst conferred a superior catalytic
      performance to the corresponding monometallic counterparts and commercial Al2O3
      or solid Al2O3 microsphere supported AuPd ones, along with a high acetophenone
      selectivity of 88.2% at a conversion of 50.9% under mild reaction conditions (120
      degrees C and oxygen pressure of 1.0 MPa), as well as an unprecedentedly high
      turnover frequency value of 46 768 h-1. Such exceptional efficiency of the
      catalyst was related to both the significant synergy between the Au-Pd atoms and
      strong metal-support interactions, and the unique hierarchical
      micro/nanostructure of the support being beneficial to the close contact of
      reactants with surface adsorption and reaction sites and easy product diffusion.
      Moreover, the present bimetallic AuPd catalyst was recyclable and stable. The
      developed approach is expected to offer exciting opportunities for designing
      other supported monometallic or bimetallic catalysts with various active
      components applied in heterogeneous catalysis.

PMID- 29845151
TI  - The influence of acceptor and donor doping on the protonic surface conduction of
      TiO2.
AB  - The transport of protonic charge carriers along and within the pore surfaces of
      porous oxide matrices is of significant importance for many catalytic and
      electrochemical applications, with porous TiO2 being a candidate material both
      for photocatalytic applications and as an electronically conducting support for
      polymer-based electrochemical cells. This work investigates the effect of
      acceptor (Cr and Fe) and donor (Nb) doping on protonic surface conduction in
      porous TiO2 over a wide range of relative humidity, temperature and oxygen
      activity. Generally, we find that acceptor dopants on the surface counteract
      dissociation and reduce the mobility of protons, while donor dopants give rise to
      enhanced dissociation making protonic surface conduction the highest for donor
      doped samples, contrary to conventional bulk proton conductors. Moreover,
      protonic surface conduction in Cr-doped TiO2 is significantly higher under
      oxidising conditions compared to reducing conditions, which we relate to the
      presence of a higher valent species such as Cr6+ on the surface under oxidising
      conditions, again emphasising that protonic surface conduction increases with
      higher-valent (donor) and more acidic cations present on the surface.

PMID- 29845152
TI  - Polyoxometalate LUMO engineering: a strategy for visible-light-responsive aerobic
      oxygenation photocatalysts.
AB  - We report the efficient visible-light-responsive photocatalysis of
      polyoxometalates (POMs) by engineering the lowest unoccupied molecular orbitals
      (LUMOs). By the introduction of vanadium atoms into the gamma-Keggin-type
      phosphotungstate, a new V3d/W5d mixed LUMO appeared to afford a visible-light
      responsive catalyst (I), which showed high photocatalytic activity for aerobic
      oxygenation of sulfides to sulfoxides.

PMID- 29845153
TI  - Combining a pyclen framework with conjugated antenna for the design of europium
      and samarium luminescent bioprobes.
AB  - The first pyclen based ligand bearing two picolinate intra-ligand charge transfer
      transition antennae and one acetate arm organized in a dissymmetric manner was
      synthesized for Eu(iii) and Sm(iii) complexation. The europium complex presents
      an excellent brightness and biphotonic imaging of T24-cells has been performed
      using Eu(iii) and the less common Sm(iii) bioprobes.

PMID- 29845154
TI  - Reconstitution of full-length P450BM3 with an artificial metal complex by
      utilising the transpeptidase Sortase A.
AB  - Haem substitution is an effective approach to tweak the function of
      haemoproteins. Herein, we report a facile haem substitution method for self
      sufficient cytochrome P450BM3 (CYP102A1) from Bacillus megaterium utilising the
      transpeptidase Sortase A from Staphylococcus aureus. We successfully constructed
      Mn-substituted BM3 and investigated its catalytic activity.

PMID- 29845155
TI  - Formation and origin of multicenter photoluminescence in zeolite-based carbogenic
      nanodots.
AB  - Carbogenic nanodots (CNDs) are inspiring intensive research efforts owing to
      their excellent optical properties; however, their chemical structures and
      photoluminescent origins are still under study. Herein, CNDs with interesting
      multicenter photoluminescence (PL) have been successfully prepared by pyrolysis
      of organo-templated zeolites. The simultaneously observed excitation-dependent
      blue and excitation-independent green PL emissions as well as an uncommon
      ultraviolet-excited cyan emission are quite different from those of the known
      multicenter emissive CNDs. To get a thorough understanding of the formation of
      these CNDs and their PL origins, structural characterizations coupled with
      femtosecond transient absorption and fluorescence lifetime spectra analyses have
      been employed to study such PL behavior. The results show that the as-prepared
      CNDs consist of three main batches with different polarities, and they are
      composed of a combination of six small fluorophores with diverse ratios. The
      multicenter PL is obtained due to competition between the conjugated domain
      fluorophores and the surface-occupied functional group fluorophores. This study
      provides a comprehensive insight into the origin of multicenter photoluminescence
      in zeolite-based CNDs.

PMID- 29845156
TI  - Electronic structure manipulation of graphene dots for effective hydrogen
      evolution from photocatalytic water decomposition.
AB  - This paper presents a heteroatom doping strategy to manipulate the structure of
      graphene-based photocatalysts for effective hydrogen production from aqueous
      solution. Oxygenation of graphene creates a bandgap to produce semiconducting
      graphene oxide, nitrogen doping extends the resonant pi-conjugation to prolong
      the charge lifetime, and sulfur doping breaks the electron neutrality to
      facilitate charge transfer. Accordingly, ammonia-treated sulfur-nitrogen-co-doped
      graphene oxide dots (A-SNGODs) are synthesized by annealing graphene oxide sheets
      in sulfur-ammonia, oxidizing the sheets into dots, and then hydrothermally
      treating the dots in ammonia. The A-SNGODs exhibit a high nitrogen content in
      terms of quaternary and amide groups that are formed through sulfur-mediated
      reactions. The peripheral amide facilitates orbital conjugations to enhance the
      photocatalytic activity, whereas the quaternary nitrogen patches vacancy defects
      to improve stability. The simultaneous presence of electron-withdrawing S and
      electron-donating N atoms in the A-SNGODs facilitates charge separation and
      results in reactive electrons. When suspended in an aqueous triethanolamine
      solution, Pt-deposited A-SNGODs demonstrate a hydrogen-evolution quantum yield of
      29% under monochromatic 420 nm irradiation. The A-SNGODs exhibit little activity
      decay under 6-day visible-light irradiation. This study demonstrates the
      excellence of the heteroatom-doping strategy in producing stable and active
      graphene-based materials for photoenergy conversion.

PMID- 29845157
TI  - Selective counting and sizing of single virus particles using fluorescent aptamer
      based nanoparticle tracking analysis.
AB  - Detection and counting of single virus particles in liquid samples are largely
      limited to narrow size distribution of viruses and purified formulations. To
      address these limitations, here we propose a calibration-free method that enables
      concurrently the selective recognition, counting and sizing of virus particles as
      demonstrated through the detection of human respiratory syncytial virus (RSV), an
      enveloped virus with a broad size distribution, in throat swab samples. RSV
      viruses were selectively labeled through their attachment glycoproteins (G) with
      fluorescent aptamers, which further enabled their identification, sizing and
      counting at the single particle level by fluorescent nanoparticle tracking
      analysis. The proposed approach seems to be generally applicable to virus
      detection and quantification. Moreover, it could be successfully applied to
      detect single RSV particles in swab samples of diagnostic relevance. Since the
      selective recognition is associated with the sizing of each detected particle,
      this method enables to discriminate viral elements linked to the virus as well as
      various virus forms and associations.

PMID- 29845158
TI  - Carbon coated core-shell multifunctional fluorescent SPIONs.
AB  - Due to their unique magnetic properties, multiple surface functionality and
      biocompatibility, superparamagnetic iron oxide nanoparticles (SPIONs) show very
      promising characteristics as magnetic resonance (MR) contrast agents in
      biomedical applications. However, a lack of fluorescence makes SPIONs
      inappropriate for multimodal bioimaging. SPIONs surface functionalized by either
      organic fluorescent molecules or semiconductor quantum dots (QDs) have been
      reported as bioimaging probes but subsequent deterioration of the fluorescent
      dyes due to low photostability and quick photobleaching limits their long term
      practical application. In addition, QDs are found to be toxic in nature. Here, we
      present a novel one step method to synthesize non-toxic carbon coated highly
      photostable core-shell magnetic and fluorescent SPIONs with long-lasting
      fluorescence alongside a superior magnetic resonance (MR) imaging ability. Apart
      from the highly comparable superparamagnetic properties of the SPIONs, the
      optical response of the material is much better than commonly used Rhodamine or
      cyanine dyes.

PMID- 29845159
TI  - Flexible hemispheric microarrays of highly pressure-sensitive sensors based on
      breath figure method.
AB  - Recently, flexible pressure sensors featuring high sensitivity, broad sensing
      range and real-time detection have aroused great attention owing to their crucial
      role in the development of artificial intelligent devices and healthcare systems.
      Herein, highly sensitive pressure sensors based on hemisphere-microarray flexible
      substrates are fabricated via inversely templating honeycomb structures deriving
      from a facile and static breath figure process. The interlocked and subtle
      microstructures greatly improve the sensing characteristics and compressibility
      of the as-prepared pressure sensor, endowing it a sensitivity as high as 196 kPa
      1 and a wide pressure sensing range (0-100 kPa), as well as other superior
      performance, including a lower detection limit of 0.5 Pa, fast response time (<26
      ms) and high reversibility (>10 000 cycles). Based on the outstanding sensing
      performance, the potential capability of our pressure sensor in capturing
      physiological information and recognizing speech signals has been demonstrated,
      indicating promising application in wearable and intelligent electronics.

PMID- 29845160
TI  - Cluster structures influenced by interaction with a surface.
AB  - Clusters on surfaces are vitally important for nanotechnological applications.
      Clearly, cluster-surface interactions heavily influence the preferred cluster
      structures, compared to clusters in vacuum. Nevertheless, systematic explorations
      and an in-depth understanding of these interactions and how they determine the
      cluster structures are still lacking. Here we present an extension of our well
      established non-deterministic global optimization package OGOLEM from isolated
      clusters to clusters on surfaces. Applying this approach to intentionally simple
      Lennard-Jones test systems, we produce a first systematic exploration that
      relates changes in cluster-surface interactions to resulting changes in adsorbed
      cluster structures.

PMID- 29845161
TI  - Network-like arrangement of mixed-valence uranium oxide nanoparticles after
      glutathione-induced reduction of uranium(vi).
AB  - Glutathione (GSH), a ubiquitous intracellular reducing tripeptide, is able to
      reduce hexavalent uranium, U(vi), to its tetravalent form, U(iv), in aqueous
      media in vitro, inducing the formation of nanocrystalline mixed-valence uranium
      oxide particles. After the initial reduction to U(v) and subsequent dismutation,
      the yielded U(iv) rapidly hydrolyses under near-neutral conditions forming 2-5 nm
      sized nanoparticles. The latter further aggregate to 20-40 nm chain-like building
      blocks that finally arrange as network-like structures.

PMID- 29845162
TI  - A critical assessment of force field accuracy against NMR data for cyclic
      peptides containing beta-amino acids.
AB  - Hybrid cyclic alpha/beta-peptides, in which one or more beta-amino acids are
      incorporated into the backbone, are gaining increasing interest as potential
      therapeutics, thanks to their ability to achieve enhanced binding affinities for
      a biological target through pre-organization in solution. The in silico
      prediction of their three dimensional structure through strategies such as MD
      simulations would substantially advance the rational design process. However,
      whether the molecular mechanics force fields are accurate in sampling highly
      constrained cyclopeptides containing beta-amino acids remains to be verified.
      Here, we present a systematic assessment of the ability of 8 widely used force
      fields to reproduce 79 NMR observables (including chemical shifts and 3J scalar
      couplings) on five cyclic alpha/beta-peptides that contain the integrin
      recognition motif isoDGR. Most of the investigated force fields, which include
      force fields from AMBER, OPLS, CHARMM and GROMOS families, display very good
      agreement with experimental 3J(HN,Halpha), suggesting that MD simulations could
      be an appropriate tool in the rational design of therapeutic cyclic alpha
      peptides. However, for NMR observables directly related to beta-amino acids, we
      observed a poor agreement with experiments and a remarkable dependence of our
      evaluation on the choice of Karplus parameters. The force field weaknesses herein
      unveiled might constitute a source of inspiration for further force field
      optimization.

PMID- 29845163
TI  - Heterojunctions of silver-iron oxide on graphene for laser-coupled oxygen
      reduction reactions.
AB  - We report a two-step hybridization of N-doped graphene and Ag-decorated Fe2O3
      hematite to realize a balanced oxygen adsorption/desorption equilibrium and a
      laser-coupled ORR (LORR). The stable plateau currents with n values of 3.9 in a
      wide potential range (0.2-0.7 V) and 7.5% peroxide inhibition of the LORR are
      found to be directly associated with the Ag/Fe2O3 heterojunction, where
      interactions of semiconductor band gap excitation and plasmonic resonance-induced
      hot electrons are proposed to occur.

PMID- 29845164
TI  - Gold-catalyzed [5+2] cycloaddition of quinolinium zwitterions and allenamides as
      an efficient route to fused 1,4-diazepines.
AB  - Herein, we demonstrate a new catalytic cycloaddition of quinolinium zwitterions
      involving a gold-bound allylic cation intermediate. This ligand-free higher-order
      cycloaddition efficiently affords a variety of fused 1,4-diazepine derivatives in
      a stereospecific manner at room temperature.

PMID- 29845166
TI  - Enhancement of the spin polarization of an Fe3O4(100) surface by nitric oxide
      adsorption.
AB  - The geometric, electronic and magnetic properties of a nitric oxide (NO) adsorbed
      Fe3O4(100) surface have been investigated using density functional theory (DFT)
      calculations. NO molecules preferentially bond with surface Fe(B) atoms via their
      N atoms. The generalized gradient approximation (GGA) is not recommended to be
      used in such a strongly correlated system since it provides not only an
      overestimation of the adsorption energy and an underestimation of the Fe(B)-N
      bond length, but also magnetic quenching of the adsorbate and the bonded Fe(B)
      atoms. In contrast, a tilted geometry and magnetization of the adsorbate and the
      bonded Fe(B) atom are obtained after including the strong on-site Coulomb
      interactions through a Hubbard term (GGA+U). The spin-down 2pi* states of the NO
      molecule are filled and broadened due to the adsorbate-substrate interaction and
      the molecule-molecule interaction. The surface spin polarization close to the
      Fermi level is expected to be greatly enhanced by the NO adsorption which has
      significance for interface design in spintronic devices.

PMID- 29845165
TI  - An acid-compatible co-polymer for the solubilization of membranes and proteins
      into lipid bilayer-containing nanoparticles.
AB  - The fundamental importance of membrane proteins in drug discovery has meant that
      membrane mimetic systems for studying membrane proteins are of increasing
      interest. One such system has been the amphipathic, negatively charged
      poly(styrene-co-maleic acid) (SMA) polymer to form "SMA Lipid Particles" (SMALPs)
      which have been widely adopted to solubilize membrane proteins directly from the
      cell membrane. However, SMALPs are only soluble under basic conditions and
      precipitate in the presence of divalent cations required for many downstream
      applications. Here, we show that the positively charged poly(styrene-co
      maleimide) (SMI) forms similar nanoparticles with comparable efficiency to SMA,
      whilst remaining functional at acidic pH and compatible with high concentrations
      of divalent cations. We have performed a detailed characterization of the
      performance of SMI that enables a direct comparison with similar data published
      for SMA. We also demonstrate that SMI is capable of extracting proteins directly
      from the cell membrane and can solubilize functional human G-protein coupled
      receptors (GPCRs) expressed in cultured HEK 293T cells. "SMILPs" thus provide an
      alternative membrane solubilization method that successfully overcomes some of
      the limitations of the SMALP method.

PMID- 29845167
TI  - Crystallographic and spectroscopic evidence for intrinsic distortion in the
      disordered crystal beta-NaGdF4.
AB  - beta-NaREF4 (RE: rare earth metals) is a peculiar crystal due to its intriguing
      disordered structure. This crystal is usually considered to have an average
      structure with a space group of P-6 (174). However, a long-term contradiction
      existing in this system is that the luminescence characteristics do not match the
      corresponding theoretical predictions based on the average structure. To resolve
      this contradiction, we proposed a reasonable local structure model clearly
      showing the local symmetry of the cations based on the measurement of the
      extended X-ray absorption fine structure of beta-NaGdF4. We also observed an
      intrinsic distortion in the disordered structure that resulted from the
      disordered arrangement of the Na+ and Gd3+ cations. Furthermore, using Eu3+ as a
      photoluminescence probe, we concluded that the breakdown in the crystallographic
      site symmetry originated from the intrinsic distortion of these crystals. This
      work provides a comprehensive explanation for the contradiction observed in this
      system and a foundation for further investigations to understand such disordered
      structures.

PMID- 29845168
TI  - Flexible, transparent and highly sensitive SERS substrates with cross-nanoporous
      structures for fast on-site detection.
AB  - A flexible and transparent film assembled from the cross-nanoporous structures of
      Au on PET (CNS of Au@PET) is developed as a versatile and effective SERS
      substrate for rapid, on-site trace analysis with high sensitivity. The
      fabrication of the CNS of Au can be achieved on a large scale at low cost by
      employing an etching process with super-aligned carbon nanotubes as a mask,
      followed by metal deposition. A strongly enhanced Raman signal with good
      uniformity can be obtained, which is attributed to the excitation of "hot spots"
      around the metal nanogaps and sharp edges. Using the CNS of Au@PET film as a SERS
      platform, real-time and on-site SERS detection of the food contaminant crystal
      violet (CV) is achieved, with a detection limit of CV solution on a tomato skin
      of 10-7 M. Owing to its ability to efficiently extract trace analytes, the
      resulting substrate also achieves detection of 4-ATP contaminants and thiram
      pesticides by swabbing the skin of an apple. A SERS detection signal for 4-ATP
      has a relative standard deviation of less than 10%, revealing the excellent
      reproducibility of the substrate. The flexible, transparent and highly sensitive
      substrates fabricated using this simple and cost-effective strategy are promising
      for practical application in rapid, on-site SERS-based detection.

PMID- 29845169
TI  - Size-tunable CsPbBr3 perovskite ring arrays for lasing.
AB  - Morphology engineering is a decisive factor for the optoelectronic properties of
      nanocrystals. Differing from morphologies with a solid interior, ring-like
      structures have a unique internal space which is not only available for loading
      chemicals, but also useful for controlling the field distribution. Herein, the
      perovskite array family welcomes a new member - CsPbBr3 ring arrays. This work
      solves several fundamental problems for fabricating CsPbBr3 ring arrays: (i)
      developing a simple method using 2D colloidal crystal templates to achieve ring
      arrays of CsPbBr3, (ii) finding two ways, say changing the template size or
      annealing of the template, to accurately tune the ring size of the array in a
      wide range from 2.6 MUm to 16.9 MUm, and (iii) investigating the dynamics of
      perovskite rings, which indicates a shrinking process towards the template
      spheres before the crystallization of the perovskites. Finally, the application
      of CsPbBr3 perovskite ring arrays to the field of lasers is shown.

PMID- 29845170
TI  - Local symmetry breaking in SnO2 nanocrystals with cobalt doping and its effect on
      optical properties.
AB  - X-ray photoemission spectroscopy (XPS), X-ray diffraction (XRD) and transmission
      electron microscopy (TEM) have been used to study the structural and
      morphological characteristics of cobalt doped tin(iv) oxide (Sn1-xCoxO2; 0 <= x
      <= 0.04) nanocrystals synthesized by a chemical co-precipitation technique.
      Electronic structure analysis using X-ray photoemission spectroscopy (XPS) shows
      the formation of tin interstitials (Sni) and reduction of oxygen vacancies (VO)
      in the host lattice on Co doping and that the doped Co exists in mixed valence
      states of +2 and +3. Using XRD, the preferential position of the Sni and doped Co
      in the unit cell of the nanocrystals have been estimated. Rietveld refinement of
      XRD data shows that samples are of single phase and variation of lattice
      constants follows Vegard's law. XRD and TEM measurements show that the
      crystallite size of the nanocrystals decrease with increase in Co doping
      concentration. SAED patterns confirm the monocrystalline nature of the samples.
      The study of the lattice dynamics using Raman spectroscopy and Fourier transform
      infrared (FTIR) spectroscopy shows the existence of many disorder activated
      forbidden optical phonon modes, along with the corresponding classical modes,
      signifying Co induced local symmetry breaking in the nanocrystals. UV-Vis
      spectroscopy shows that the optical band gap has red shifted with increase in
      doping concentration. The study of Urbach energy confirms the increase in
      disorder in the nanocrystals with Co doping. Local symmetry breaking induced UV
      emission along with violet, blue and green luminescence has been observed from
      the PL study. The spectral contribution of UV emission decreases and green
      luminescence increases with increase in doping. Using PL, in conjunction with
      Raman spectroscopy, the type of oxygen vacancy induced in the nanocrystals on Co
      doping has been confirmed and the position of the defect levels in the forbidden
      zone (w.r.t. the optical band gap) has been studied.

PMID- 29845171
TI  - Graphite felts modified by vertical two-dimensional WO3 nanowall arrays: high
      performance electrode materials for cerium-based redox flow batteries.
AB  - Cerium-based redox flow batteries (RFBs) are very attractive for highly efficient
      energy storage applications with industrial-scale storage capacity. However, the
      development of active, stable, and earth-abundant catalysts for cerium redox
      reactions with sluggish kinetics remains a major challenge. Herein, for the first
      time, two-dimensional (2D) nanostructured architectures were used to design and
      fabricate efficient and stable electrocatalysts from earth-abundant components
      toward the Ce(iv)/Ce(iii) redox reaction. A novel WO3/GF hybrid architecture
      (WGF) built from WO3 nanowall arrays (NWAs) anchored on graphite felt (GF)
      surfaces was prepared for cerium-based RFBs. This unique hybrid exhibits superior
      electrocatalytic performance since the vertical nanowall arrays display open and
      ordered structures that ensure full exposure of the active sites toward
      electrolytes, which allows direct and full contact of every nanowall with the
      electrolyte. As an electrode for cerium redox reactions, this WGF electrode
      exhibits a 42.1% and 32.0% increase in energy efficiency as compared with that of
      pristine GF and acid-treated GF at a high charge/discharge rate of 30 mA cm-2.
      Moreover, the long-term cycling performance confirms the superior durability of
      the as-prepared WGF. This study suggests that the use of 2D nanostructures
      combined with vertical array microstructures is a promising strategy for
      efficient electrocatalysts toward cerium redox reactions with scale-up potential.

PMID- 29845172
TI  - Synthesis and biochemical evaluation of two novel N-hydroxyalkylated cyclosporin
      A analogs.
AB  - The cyclic undecapeptide cyclosporin A (CsA) is a widely used immunosuppressive
      agent. Its immunosuppressive properties arise from strong binding to cyclophilins
      (Cyp) followed by inhibition of the protein calcineurin (CaN) by the binary
      CsA/Cyp complex and subsequent negative regulation of T-cell activation. In the
      present study we show a novel way to modify the CsA ring by selective N
      hydroxyalkylation of the residues Val5 and d-Ala8. Moreover, the influence of
      these structural CsA modifications on the ability of the CsA analogs to bind Cyp,
      to inhibit CaN and to penetrate membranes of living cells was investigated. Our
      results show that the Val5 N-substitution significantly improved compound cell
      permeability and markedly diminished CaN inhibition by the binary CsA analog/CypA
      complex but to a lesser extent Cyp inhibition. In contrast, the N-alkylation of d
      Ala8 gave a product with significantly reduced affinity for Cyp but its
      immunosuppressive effects remained similar to CsA. Possible explanations of the
      observed experimental data are provided by computational studies.

PMID- 29845173
TI  - Design and preparation of sandwich-like polydimethylsiloxane (PDMS) sponges with
      super-low ice adhesion.
AB  - The mitigation of ice on exposed surfaces is of great importance to many aspects
      of life. Ice accretion, however, is unavoidable as time elapses and temperature
      lowers sufficiently. One practical solution is to reduce the ice adhesion
      strength on a surface to as low as possible, by either decreasing the substrate
      elastic modulus, lowering surface energy or increasing the length of cracks at
      the ice-solid interface. Herein, we present a facile preparation of
      polydimethylsiloxane (PDMS) based sandwich-like sponges with super-low ice
      adhesion. The weight ratio of the PDMS prepolymer to the curing agent is tuned to
      a lower surface energy and elastic modulus. The introduction of PDMS sponge
      structures combined the advantages of both a reduced apparent elastic modulus and
      most importantly, the macroscopic crack initiators at the ice-solid interface,
      resulting in dramatic reduction of the ice adhesion strength. Our design of
      sandwich-like sponges achieved a low ice adhesion strength as low as 0.9 kPa for
      pure PDMS materials without any additives. The super-low ice adhesion strength
      remains constant after 25 icing and deicing cycles. We thus provide a new and low
      cost approach to realize durable super-low ice adhesion surfaces.

PMID- 29845174
TI  - Nonlinear optical potassium niobate nanocrystals as harmonic markers: the role of
      precursors and stoichiometry in hydrothermal synthesis.
AB  - Nanocrystals of alkaline niobates are currently being discussed for various
      applications because of their diverse and remarkable properties. Although the
      growth of bulk niobate crystals is well established, little is known about
      respective nanocrystals and the optical properties of niobates below 100 nm. A
      systematic view of the hydrothermal synthesis of potassium niobate with respect
      to the precursor species reveals the sensitive dependence of the resulting
      crystalline phases and sizes on the educt modifications. With a variation of
      stoichiometry of the procedure, the product modification and crystallite size can
      be changed. By means of second harmonic generation, nanocrystalline potassium
      niobate offers the possibility for use as an optical marker in high resolution
      nonlinear microscopy. Redispersed particles show a significant second harmonic
      generation signal throughout the visible spectral range.

PMID- 29845175
TI  - Optical bandgap modelling from the structural arrangement of carbon nanotubes.
AB  - The optical bandgap properties of vertically-aligned carbon nanotube (VACNT)
      arrays were probed through their interaction with white light, with the light
      reflected from the rotating arrays measured with a spectrometer. The precise
      deterministic control over the structure of vertically-aligned carbon nanotube
      arrays through electron beam lithography and well-controlled growth conditions
      brings with it the ability to produce exotic photonic crystals over a relatively
      large area. The characterisation of the behaviour of these materials in the
      presence of light is a necessary first step toward application. Relatively large
      area array structures of high-quality VACNTs were fabricated in square,
      hexagonal, circular and pseudorandom patterned arrays with length scales on the
      order of those of visible light for the purpose of investigating how they may be
      used to manipulate an impinging light beam. In order to investigate the optical
      properties of these arrays a set of measurement apparatus was designed which
      allowed the accurate measurement of their optical bandgap characteristics. The
      patterned samples were rotated under the illuminating white light beam, revealing
      interesting optical bandgap results caused by the changing patterns and relative
      positions of the scattering elements (VACNTs).

PMID- 29845181
TI  - Novel protein-lipid composite nanoparticles with an inner aqueous compartment as
      delivery systems of hydrophilic nutraceutical compounds.
AB  - Food protein and lipid based nanoparticles have attracted recent interest as a
      means of delivering nutraceuticals. Nanoparticle encapsulation of nutraceuticals
      faces challenges to overcome for it to be readily applied in the food industry,
      such as low encapsulation efficiency for hydrophilic compounds and poor stability
      once in the gastrointestinal tract. This research introduces a new protein-lipid
      composite nanoparticle with a three-layered structure (a barley protein layer,
      alpha-tocopherol layer and phospholipid layer) and an inner aqueous compartment
      to load hydrophilic nutraceuticals. This delivery system showed efficient
      encapsulation of vitamin B12 (69%) and controlled release behavior in simulated
      gastrointestinal media. An in vitro cell evaluation demonstrated that
      nanoparticles could internalize into Caco-2 cells via energy-dependent
      endocytosis and significantly increase the uptake and transport efficiency of
      vitamin B12 in this model. In vivo, the developed vitamin B12 loaded nanoparticle
      showed increased serum vitamin B12 levels upon oral administration and reduced
      the methylmalonic acid level more efficiently than the free form in rats. A 14
      day in vivo toxicity study showed no evidence of toxicity in rats implying the
      safety of the developed nanoparticles in long term use. Overall, the results of
      this study show the great potential of the developed nanoparticles in increasing
      the absorption of vitamin B12 upon oral administration.

PMID- 29845182
TI  - A protocol for quantifying hydrogen evolution by dye-sensitized molecular
      photocathodes and its implementation for evaluating a new covalent architecture
      based on an optimized dye-catalyst dyad.
AB  - A protocol that combines gas chromatography and a high-sensitivity micro Clark
      type electrode is described to quantify hydrogen production across gas and
      solution phases for systems operating at very low currents such as dye-sensitized
      H2-evolving photocathodes. Data indicate that a significant fraction of H2
      remains in aqueous solution even after several hours of experiments. Using this
      protocol, re-evaluation of a dye-sensitized H2-evolving photocathode based on a
      dye-catalyst dyad showed a reproducible 66% increase of the faradaic efficiency
      compared with previously reported headspace GC measurements [Kaeffer et al., J.
      Am. Chem. Soc., 2016, 138, 12308-12311]. This dyad was based on an organic push
      pull dye where donor and acceptor are separated by one thiophene group. Insertion
      of a second thiophene group between the donor and acceptor led to a more
      efficient system with 30% improved faradaic efficiency for H2 evolution.

PMID- 29845183
TI  - The deposition of metal nanoparticles on carbon surfaces: the role of specific
      functional groups.
AB  - The enormous complexity of a typical heterogeneous catalyst makes understanding
      the development and properties of any active nanoparticles present extremely
      challenging. In the case of carbon based catalysts that difficulty is compounded
      by the variability of the carbon powders used. We have previously developed a
      strategy that addresses these problems by mimicking the catalyst preparation
      conditions very closely but using highly ordered pyrolytic graphite crystals
      (HOPG) as a model surface. This enables us to examine the effects of specific
      functional groups on nanoparticle formation. We report here an extension of our
      work characterising functional groups on the HOPG surface, using XPS and AFM to
      explore the deposition of gold from aqueous solution onto HOPG surfaces treated
      in a variety of ways to alter the surface functionality. The structure and
      oxidation state of the resulting nanoparticles depend critically on the nature of
      the functional groups present and offers some insight into the development of
      catalysts based on these materials. Hydroxyls are identified as key functional
      species, reducing gold ions to their metallic state whilst being oxidised
      themselves to carbonyls. Carbonyls meanwhile promote the nucleation of Au3+,
      creating a network of islands at the HOPG surface. The results have relevance not
      only to catalysts using activated carbons but also the new generation of
      materials based on graphene and carbon nanotubes.

PMID- 29845184
TI  - 31P and 195Pt solid-state NMR and DFT studies on platinum(i) and platinum(ii)
      complexes.
AB  - 31P and 195Pt solid state NMR spectra of anti-[(PHCy)ClPt(MU-PCy2)2Pt(PHCy)Cl]
      (3) and [(PHCy2)Pt(MU-PCy2)(kappa2P,O-MU-POCy2)Pt(PHCy2)] (Pt-Pt) (4) were
      recorded under cross polarization/magic-angle spinning conditions (31P) or with
      the cross polarization/Carr-Purcell-Meiboom-Gill pulse sequence (195Pt) and
      compared to the data obtained by relativistic DFT calculations of 31P and 195Pt
      CS tensors and isotropic shielding at the ZORA spin-orbit level. A good agreement
      with the experimental results was found and it was possible to rationalize the
      chemical shift differences of 195Pt and 31P nuclei between compounds 3 and 4 as
      mostly due to a change (in opposite directions for 195Pt and 31P) of the
      principal component of the shielding tensor perpendicular to the molecular plane
      defined by the Pt and P atoms. Paramagnetic and spin-orbit terms were found to be
      the most important contributions to 195Pt and 31P shielding.

PMID- 29845185
TI  - Single entity electrocatalysis: oxygen reduction mediated via methyl viologen
      doped Nafion nanoparticles.
AB  - Nafion particles doped with methyl viologen are shown to be electrocatalytic
      towards oxygen reduction in aqueous solution when immobilised on a carbon
      electrode surface, with the formation of hydrogen peroxide. In this way an
      efficient homogeneous electron transfer mediator, methyl viologen, can be
      confined to act heterogeneously with the benefits of that type of process without
      losing effectiveness. Kinetic and mechanistic parameters are deduced from cyclic
      voltammetry and from single entity nano-impact experiments, and the process is
      shown to occur via electron transfer to dioxygen at the Nafion particle-solution
      interface with the initial formation of superoxide.

PMID- 29845186
TI  - Understanding the surface properties and rheology of a silica suspension mediated
      by a comb-type poly(acrylic acid)/poly(ethylene oxide) (PAA/PEO) copolymer:
      effect of salinity.
AB  - Understanding the surface properties and rheology of colloidal suspensions in the
      presence of polymer additives with high salinity are of great importance in
      formulating construction materials and optimizing process conditions in the
      mining and petroleum industry. In this work, the surface properties and rheology
      of a model spherical silica aqueous suspension mediated by a comb-type
      poly(acrylic acid)/poly(ethylene oxide) (PAA/PEO) copolymer at various salt
      concentrations have been investigated. Adsorption measurements using a Quartz
      Crystal Microbalance with Dissipation monitoring (QCM-D) align well with zeta
      potential tests and show that polymer adsorption on silica surfaces is enhanced
      at high salinity (i.e., 3 M NaCl) than at low salinity (i.e., 1 mM NaCl) due to
      the suppression of the electrical double layer. Surface Forces Apparatus (SFA)
      measurements reveal that for interactions between two mica surfaces (the basal
      plane of which has a similar structure as silica) at a high polymer concentration
      (e.g., 2 wt%), steric repulsion dominates in 1 mM NaCl while bridging attraction
      is observed in 3 M NaCl. Surface force measurements agree with rheological
      results on silica suspensions with 0.5 to 2 wt% of PAA/PEO addition, which shows
      a significant decrease in yield stress in 1 mM NaCl due to steric repulsion but
      an insignificant variation in yield stress in 3 M NaCl due to attractive bridging
      interactions. This work provides useful information regarding the surface
      properties and rheological properties of comb-type polymer-mediated silica
      suspensions under different salinity conditions, with implications on designing
      and processing complex colloidal suspensions with polymer additives for various
      applications.

PMID- 29845187
TI  - A Matrixed Speech-in-Noise Test to Discriminate Favorable Listening Conditions by
      Means of Intelligibility and Response Time Results.
AB  - Purpose: The primary aim of this study was to develop and examine the potentials
      of a new speech-in-noise test in discriminating the favorable listening
      conditions targeted in the acoustical design of communication spaces. The test is
      based on the recognition and recall of disyllabic word sequences. A secondary aim
      was to compare the test with current speech-in-noise tests, assessing its
      benefits and limitations. Method: Young adults (19-40 years old), self-reporting
      normal hearing, were presented with the newly developed Words Sequence Test (WST;
      16 participants, Experiment 1) and with a consonant confusion test and a sentence
      recognition test (Experiment 2, 36 participants randomly assigned to the 2
      tests). Participants performing the WST were presented with word sequences of
      different lengths (from 2 up to 6 words). Two listening conditions were selected:
      (a) no noise and no reverberation, and (b) reverberant, steady-state noise
      (Speech Transmission Index: 0.47). The tests were presented in a closed-set
      format; data on the number of words correctly recognized (speech intelligibility,
      IS) and the response times (RTs) were collected (onset RT, single words' RT).
      Results: It was found that a sequence composed of 4 disyllabic words ensured both
      the full recognition score in quiet conditions and a significant decrease in IS
      results when noise and reverberation degraded the speech signal. RTs increased
      with the worsening of the listening conditions and the number of words of the
      sequence. The greatest onset RT variation was found when using a sequence of 4
      words. In the comparison with current speech-in-noise tests, it was found that
      the WST maximized the IS difference between the selected listening conditions as
      well as the RT increase. Conclusions: Overall, the results suggest that the new
      speech-in-noise test has good potentials in discriminating conditions with near
      ceiling accuracy. As compared with current speech-in-noise tests, it appears that
      the WST with a 4-word sequence allows for a finer mapping of the acoustical
      design target conditions of public spaces through accuracy and onset RT data.

PMID- 29845188
TI  - lncRNA Ftx promotes aerobic glycolysis and tumor progression through the
      PPARgamma pathway in hepatocellular carcinoma.
AB  - Aerobic glycolysis is a phenomenon by which malignant cells preferentially
      metabolize glucose through the glycolytic pathway, rather than oxidative
      phosphorylation to proliferate efficiently. The present study aimed to
      investigate the expression and functional implications of long non-coding
      (lnc)RNA Ftx in the aerobic glycolysis and tumorigenesis of hepatocellular
      carcinoma (HCC). It was identified that lncRNA Ftx was upregulated in human HCC
      tissues and cell lines and, notably, was associated with aggressive
      clinicopathological features. lncRNA Ftx overexpression promoted the
      proliferation, invasion and migration of HCC cells, whereas lncRNA Ftx knockdown
      resulted in the opposite effects. Furthermore, lncRNA Ftx affected the activity
      and expression of key enzymes in carbohydrate metabolism, suggesting that lncRNA
      Ftx may be involved in aerobic glycolysis in HCC. The measurement of glucose
      consumption, lactate production and glucose transporter expression further
      supported this assumption. Mechanistically, peroxisome proliferator-activated
      receptor gamma (PPARgamma) expression in human HCC tissues and cell lines was
      positively correlated with lncRNA Ftx. Inhibiting PPARgamma in Huh7 cells
      partially abrogated the alterations in glucose uptake, lactate production and
      relative glycolytic enzyme expression induced by lncRNA Ftx; similarly, PPARgamma
      activation in Bel-7402 cells partially rescued the lncRNA Ftx-mediated
      alterations. In conclusion, lncRNA Ftx is a promoter of the Warburg effect and
      tumor progression, partly via the PPARgamma pathway, and may serve as a promising
      therapeutic target for HCC treatment.

PMID- 29845189
TI  - Matrine inhibits the invasive and migratory properties of human hepatocellular
      carcinoma by regulating epithelial-mesenchymal transition.
AB  - Matrine has been reported to be an effective anti-tumor therapy; however, the
      anti-metastatic effects of matrine on hepatocellular carcinoma (HCC) and the
      molecular mechanism(s) involved remain unclear. Therefore, the aims of the
      present study were to evaluate the effects of matrine on hepatoma and to
      determine the associated mechanism(s) involved. In the present study, matrine was
      confirmed to prevent the proliferation of HCC cells and it was observed that
      matrine also inhibited the migratory, and invasive capabilities of HCC at non
      toxic concentrations. Additionally, matrine increased epithelial-cadherin
      expression and decreased the expression levels of vimentin, matrix
      metalloproteinase (MMP)2, MMP9, zinc finger protein SNAI1 and zinc finger protein
      SNAI2. These results indicate that the anti-metastatic effect of matrine may be
      associated with epithelial-mesenchymal transition (EMT). Furthermore, matrine can
      increase phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual
      specificity protein phosphatase PTEN (PTEN) expression and reduce phosphorylated
      protein kinase B (Akt) levels. In conclusion, these results suggested that
      matrine is a potential therapeutic agent that can suppress cancer-associated
      invasion and migration via PTEN/Akt-dependent inhibition of EMT.

PMID- 29845190
TI  - Dysregulation of microRNA-23b-3p contributes to the development of intracranial
      aneurysms by targeting phosphatase and tensin homolog.
AB  - MicroRNA-23b-3p (miR-23b-3p) has been reported to be involved in the pathogenesis
      of a number of diseases, including non-small cell lung cancer and gastric cancer,
      by acting on different signaling pathways. The present study aimed to understand
      the association between the miR-23b-3p level of intracranial aneurysms (IAs) and
      the mechanism involved. Computational analysis was used to search for the target
      of miR-23b-3p, and luciferase assay was used to validate the miRNA/target
      association. Western blot analysis and reverse transcription-quantitative
      polymerase chain reaction (RT-qPCR) were used to determine the expression of miR
      23b-3p and phosphatase and tensin homolog (PTEN), and their expression in smooth
      muscle cells (SMCs) treated with miRNA mimic or inhibitor. Firstly, an online
      miRNA database (www.mirdb.org) was searched using the 'seed sequence' located
      within the 3'-untranslated region of the target gene, and then PTEN was validated
      as the direct target gene via a luciferase reporter assay system. The negative
      regulatory association between miR-23b-3p and PTEN was determined through the
      analysis of the relative luciferase activity. Additionally, RT-qPCR and western
      blot analysis was performed in order to assess the mRNA and protein expression
      levels of PTEN among IA (n=32) and control (n=17) groups or cells treated with
      scramble control, miR-23b-3p mimics, PTEN siRNA and miR-23b-3p inhibitors to
      verify the negative regulatory association between miR-23b-3p and PTEN.
      Experiments were then performed to investigate the effect of miR-23b-3p and PTEN
      on the viability and apoptosis of pulmonary artery SMCs (PASMCs). The results
      showed that cells transfected with miR-23b-3p inhibitors suppressed the viability
      of SMCs by promoting the apoptosis of the cells compared with that of the
      scramble controls, while cells transfected with miR-23b-3p mimics and PTEN siRNA
      enhanced the viability of VSMCs by inducing apoptosis. This indicated that miR
      23b-3p negatively interfered with the viability of the cells, while PTEN
      positively interfered with the viability of the cells. In conclusion, PTEN was
      found to be a virtual target of miR-23b-3p, and a negative regulatory association
      existed between miR-23b-3p and PTEN. miR-23b-3p and PTEN interfered with the
      viability and apoptosis of SMCs.

PMID- 29845191
TI  - Inhibitory effects of silybin on the efflux pump of methicillin-resistant
      Staphylococcus aureus.
AB  - Bacterial multidrug resistance efflux systems serve an important role in
      antimicrobial resistance. Thus, identifying novel and effective efflux pump
      inhibitors that are safe with no adverse side effects is urgently required.
      Silybin is a flavonolignan component of the extract from the milk thistle seed.
      To order to investigate the mechanism by which silybin inhibits the efflux system
      of methicillin-resistant Staphylococcus aureus (MRSA), antimicrobial
      susceptibility testing and the double-plate method were used to evaluate the
      effect of silybin on MRSA41577. The ability of silybin to inhibit the efflux of
      ciprofloxacin from MRSA was evaluated by performing a fluorescence assay. Reverse
      transcription-quantitative polymerase chain reaction analysis revealed that
      silybin reduced the expression of the quinolone resistance protein NorA (norA)
      and quaternary ammonium resistance proteins A/B (qacA/B) efflux genes in MRSA.
      This suggested that silybin may effectively inhibit the efflux system of
      MRSA41577. Compared with the control, MRSA41577 treated with silybin for 16 h
      exhibited a 36 and 49% reduction in the expression of norA and qacA/B,
      respectively. Inhibition of the expression of these genes by silybin restored the
      sensitivity of MRSA41577 to antibiotics, indicating that efflux pump inhibitors,
      which act by inhibiting the efflux system of MRSA, may disrupt the MRSA
      resistance to antibiotics, rendering the bacteria sensitive to these drugs.

PMID- 29845192
TI  - Capturing antibacterial natural products with in silico techniques.
AB  - The aim of the present study was to index natural products in order to facilitate
      the discovery of less expensive antibacterial therapeutic drugs. Thus, for
      modeling purposes, the present study utilized a set of 628 antibacterial drugs,
      representing the active domain, and 2,892 natural products, representing the
      inactive domain. In addition, using the iterative stochastic elimination
      algorithm, 36 unique filters were identified, which were then used to construct a
      highly discriminative and robust model tailored to index natural products for
      their antibacterial bioactivity. The area attained under the curve was 0.957,
      indicating a highly discriminative and robust prediction model. Utilizing the
      proposed model to virtually screen a mixed set of active and inactive substances
      enabled the present study to capture 72% of the antibacterial drugs in the top 1%
      of the sample, yielding an enrichment factor of 72. In total, 10 natural products
      that scored highly as antibacterial drug candidates with the proposed indexing
      model were reported. PubMed searches revealed that 2 molecules out of the 10
      (caffeine and ricinine) have been tested and identified as showing antibacterial
      activity. The other 8 phytochemicals await experimental evaluation. Due to the
      efficiency and rapidity of the proposed prediction model, it could be applied to
      the virtual screening of large chemical databases to facilitate the drug
      discovery and development processes for antibacterial drug candidates.

PMID- 29845193
TI  - Endothelial cells and endothelin-1 promote the odontogenic differentiation of
      dental pulp stem cells.
AB  - It has been established that dental pulp stem cells (DPSCs) serve an important
      role in the restoration and regeneration of dental tissues. DPSCs are present in
      blood vessels and also exist in the vessel microenvironment in vivo and have a
      close association with endothelial cells (ECs). The present study aimed to
      evaluate the influence of ECs and their secretory product endothelin-1 (ET-1) on
      the differentiation of DPSCs. In the present study, cells were divided into four
      groups: i) a DPSC-only control group; ii) a DPSC with ET-1 administration group;
      iii) a DPSC and human umbilical vein endothelial cell (HUVEC) direct co-culture
      group; and iv) a DPSC and HUVEC indirect co-culture group using a Transwell
      system. Reverse transcription-quantitative polymerase chain reaction was used to
      detect the expression of the odontoblastic differentiation-associated genes,
      including dentin sialoprotein (DSP) and dentin matrix acidic phosphoprotein 1
      (DMP-1) at days 4, 7, 14 and 21. Alizarin Red S staining, immunofluorescence and
      western blot analyses were also conducted to assess the differentiation of the
      DPSCs in each group. The highest expression levels of odontoblastic
      differentiation-associated genes were observed on day 7 and in the two co-culture
      groups were increased compared with the DPSC-only and DPSC + ET-1 culture groups
      at all four time points. However, expression levels in the DPSC + ET-1 group were
      not downregulated as notably as in the co-culture groups on days 14 and 21. The
      Transwell group exhibited the greatest ability for odontoblastic differentiation
      compared with the other groups according to staining with Alizarin Red S,
      immunofluorescence and western blot analysis results. According to the results of
      the present study, the culture solution with HUVECs affected the differentiation
      of DPSCs. In addition, ET-1 may promote the odontoblastic differentiation of
      DPSCs.

PMID- 29845194
TI  - Atorvastatin protects BV-2 mouse microglia and hippocampal neurons against oxygen
      glucose deprivation-induced neuronal inflammatory injury by suppressing the
      TLR4/TRAF6/NF-kappaB pathway.
AB  - Atorvastatin is a member of the statin class of drugs, which competitively
      inhibit the activity of 5-hydroxy-3-methylglutaryl-coenzyme A reductase. The aim
      of the present study was to assess whether atorvastatin may protect BV-2
      microglia and hippocampal neurons against oxygen-glucose deprivation (OGD)
      induced neuronal inflammatory injury and to determine the underlying mechanisms
      by which its effects are produced. Cell viability and apoptotic ability were
      assessed using an MTT assay and annexin V-fluorescein isothiocyanate/propidium
      iodide double staining followed by flow cytometry, respectively. The expression
      of inflammation and apoptosis-associated mRNAs and proteins were assessed using
      reverse transcription-quantitative polymerase chain reaction and western
      blotting, and the expression of inflammatory factors was determined using ELISA.
      The results of the current study revealed that atorvastatin treatment suppressed
      the viability of OGD BV-2 microglia and hippocampal neurons. Furthermore,
      atorvastatin treatment reduced the expression of proinflammatory factors in OGD
      BV-2 microglia. Additionally, it was demonstrated to downregulate the toll-like
      receptor 4 (TLR4)/tumor necrosis factor receptor-associated factor 6
      (TRAF6)/nuclear factor-kappaB (NF-kappaB) pathway in OGD BV-2 microglia.
      Atorvastatin also inhibited the apoptosis of OGD hippocampal neurons by
      regulating the expression of apoptosis-associated proteins. It was concluded that
      atorvastatin treatment may protect BV-2 microglia and hippocampal neurons from
      OGD-induced neuronal inflammatory injury by suppressing the TLR4/TRAF6/NF-kappaB
      pathway. This may provide a potential strategy for the treatment of neuronal
      injury.

PMID- 29845195
TI  - Lysine-specific demethylase 2 contributes to the proliferation of small cell lung
      cancer by regulating the expression of TFPI-2.
AB  - The present study aimed to investigate the effect of lysine-specific demethylase
      2 (LSD2) in small cell lung cancer (SCLC) and explore its underlying regulatory
      mechanism. Cell growth was tested by MTT assay and mRNA and protein expression
      was determined by quantitative polymerase chain reaction (q-PCR) and western blot
      analysis, respectively. Chromatin immunoprecipitation (ChIP) was used to
      investigate the degree of H3K4me2 enrichment in the promoter region of tissue
      factor pathway inhibitor-2 (TFPI-2). SCLC tissues and cell lines presented
      significantly higher expression of LSD2 and DNA methyltransferase 3B (DNMT3B) and
      lower expression of TFPI-2 compared with the controls. In H1417 cells LSD2
      overexpression increased the mRNA and protein expression of DNMT3B, while
      inhibiting the mRNA and protein expression of TFPI-2. Following transfection with
      short interfering (si) RNA-DNMT3B, the expression of TFPI-2 increased in H1417
      cells. The results of ChIP demonstrated that compared with the controls, H3K4me1
      enrichment in the TFPI-2 promoter region was to a lower degree in the H1417 cells
      with LSD2 overexpression and a higher degree in the H1417 cells with LSD2
      silencing. MTT assays revealed that LSD2 overexpression significantly promoted
      the growth of H69, DMS-114 and H1417 cells, which was contradictory to the effect
      on LSD2 silencing. Compared with the LSD2 overexpression cells, SCLC cells with
      simultaneous overexpression of LSD2 and TFPI-2 demonstrated a decreased
      proliferation. These results suggest that LSD2 achieves a promoting effect on
      SCLC by indirectly regulating TFPI-2 expression through the mediation of DNMT3B
      expression or through the regulation of the demethylation of H3K4me1 in the
      promoter region of the TFPI-2 gene.

PMID- 29845196
TI  - Cyclin-dependent kinase 10 prevents glioma metastasis via modulation of Snail
      expression.
AB  - Cyclin-dependent kinase 10 (CDK10) has been indicated to be a candidate tumor
      suppressor in multiple cancer types. However, to the best of the authors'
      knowledge, its biological and regulatory functions in glioma have not been
      previously reported. In the present study, it was demonstrated that
      overexpression of CDK10 inhibited glioma cell proliferation and metastasis. By
      contrast, knockdown of CDK10 expression promoted these malignant phenotypes. It
      was additionally indicated that dysregulated CDK10 expression was associated with
      epithelial-mesenchymal transition (EMT) and that it regulated the expression of
      zinc finger protein SNAI1 (Snail). Furthermore, silencing Snail expression
      rescued EMT phenotypes induced by CDK10 knockdown, suggesting that Snail may be
      involved in the mechanistic association between CDK10 and EMT. The present study
      illustrated that downregulation of CDK10 expression activated Snail-driven EMT
      and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a
      potential molecular target for glioma therapy.

PMID- 29845197
TI  - Tanshinone IIA regulates colorectal cancer apoptosis via attenuation of Parkin
      mediated mitophagy by suppressing AMPK/Skp2 pathways.
AB  - Mitophagy is important for cancer development. Notably, the role of Parkin
      mediated mitophagy in colorectal cancer (CRC) mortality has not been fully
      determined. Therefore, the present study aimed to investigate the effect of
      Parkin-mediated mitophagy on CRC apoptosis. In addition, the present study
      investigated the therapeutic effects of Tanshinone IIA (Tan IIA) on the
      regulation of CRC cell death via mitophagy. Cellular apoptosis was measured
      following Tan IIA treatment. In addition, mitophagy activity was evaluated by
      immunofluorescence and western blotting. The results of the present study
      revealed that Tan IIA may enhance CRC cell death. In addition, the results
      demonstrated that Tan IIA enhanced mitochondrial apoptosis, as demonstrated by
      reduced mitochondrial membrane potential, elevated mitochondrial permeability
      transition pore opening, and increased oxidative stress, mitochondrial energy
      disorder and proapoptotic factor expression. Furthermore, the results of the
      present study demonstrated that Tan IIA induced mitochondrial apoptosis via
      inhibition of mitophagy. In addition, it was revealed that mitophagy could
      suppress mitochondrial apoptosis. Functional assays revealed that Tan IIA
      suppressed the adenosine monophosphate-activated protein kinase (AMPK) pathway,
      resulting in the inactivation of S-phase kinase associated protein 2 (Skp2).
      Furthermore, reduced levels of Skp2 failed to activate Parkin, thus resulting in
      inhibition of mitophagy. Conversely, reactivation of AMPK and overexpression of
      Skp2 rescued mitophagy activity and thus attenuated the Tan IIA-induced apoptosis
      of CRC cells. In conclusion, the results of the present study demonstrated the
      beneficial role of mitophagy in CRC cell survival and suggested that Tan IIA may
      be an effective therapeutic agent, which suppresses mitophagy activity and
      enhances CRC apoptosis.

PMID- 29845198
TI  - Hypoxia induces lactate secretion and glycolytic efflux by downregulating
      mitochondrial pyruvate carrier levels in human umbilical vein endothelial cells.
AB  - The mitochondrial pyruvate carrier (MPC) complex, located on the inner
      mitochondrial membrane, transports pyruvate to the mitochondrial matrix for
      oxidative phosphorylation. Previous studies have shown that the MPC complex is a
      key regulator of glycolysis in tumor cells. The present study evaluated the role
      of the MPC under hypoxic conditions in human umbilical vein endothelial cells,
      which rely on glycolysis for energy generation. It was indicated that hypoxia led
      to an increase in lactate secretion and a decrease in MPC1 and MPC2 levels, which
      were upregulated following re-oxygenation. In addition, the knockdown of MPC1 or
      treatment with the MPC inhibitor UK5099 increased the levels of glycolytic
      enzymes, HK2, PFKFB3, and LDHA, promoting glycolysis and lactate secretion. Taken
      together, the present data revealed that hypoxia can induce lactate secretion and
      glycolytic efflux by downregulating MPC levels.

PMID- 29845199
TI  - Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat
      livers donated after cardiac death by activating the Keap1/Nrf2-ARE signaling
      pathway.
AB  - Hypothermic machine perfusion (HMP) has been demonstrated to be a more effective
      method for preserving livers donated after circulatory death (DCD) than cold
      storage (CS); however, the underlying mechanisms remain unclear. The aim of the
      present study was to investigate the protective effects of HMP on rat DCD livers
      and the possible role of the nuclear factor erythroid 2-related factor 2
      (Nrf2)/antioxidant response element (ARE) signaling pathway. A total of 18 adult
      male rats were randomly divided into three groups: Control, HMP and CS (n=6 per
      group). To simulate the conditions of DCD liver transplantation, rat livers in
      the CS and HMP groups were subjected to 30 min warm ischemia following cardiac
      arrest and were then preserved by CS or HMP for 3 h. Subsequently, after 1 h of
      isolated reperfusion, the extent of ischemia/reperfusion injury (IRI) and
      cellular functions were assessed. During reperfusion, intrahepatic resistance and
      bile production were measured, and the perfusion fluid was collected for liver
      enzyme analysis. The liver tissues were then harvested for the assessment of
      malondialdehyde (MDA) production, superoxide dismutase (SOD) activity, ATP
      levels, as well as for histological analysis, immunohistochemistry and a terminal
      deoxynucleotidyl transferase dUTP nick end labeling assay. Finally, the
      expression levels of the components associated with the Nrf2-ARE signaling
      pathway were analyzed via western blotting and reverse transcription-quantitative
      polymerase chain reaction. The results of the present study revealed that,
      compared with in the CS group, the HMP group exhibited higher levels of ATP, bile
      production and SOD activity, and improved histological results; however, lower
      levels of liver enzymes, apoptosis and MDA were detected. Additionally, the
      findings of the present study also suggested that the Nrf2-ARE signaling pathway
      may be activated by the steady laminar flow of HMP. In conclusion, HMP may
      attenuate ischemia-reperfusion injury to rat DCD livers via activation of the
      Nrf2-ARE signaling pathway.

PMID- 29845200
TI  - Epithelial-mesenchymal transition was identified as a potential marker for breast
      cancer aggressiveness using reverse transcription-quantitative polymerase chain
      reaction.
AB  - The primary cause of breast cancer-associated mortality is the formation of
      distant metastasis. During the metastatic process, single tumor cells dissolve
      from the primary tumor site and undergo various changes in cell adhesion and
      motility properties. The tumor cells invade the blood stream and travel to
      different sites of the body, where they may initiate outgrowth. These cells are
      referred to as circulating tumor cells (CTCs). The process of changing cellular
      properties is known as epithelial to mesenchymal transition (EMT). As a different
      set of genes is upregulated during EMT, such genes may serve as marker genes for
      the detection of CTCs based on reverse transcription-quantitative polymerase
      chain reaction (RT-qPCR). Therefore, EMT- and breast cancer-related genes were
      selected as RT-qPCR markers. These genes were tested for performance in a model
      system of blood samples from healthy donors, to which a number of various breast
      cancer cell lines were added. The genes with optimal performance were
      subsequently used in RT-qPCR with 35 breast cancer patient samples. The genes
      which showed the highest and most consistent increase in gene expression with the
      increase in the number of cancer cell line cells added were CK19, Snail, FoxC2
      and Twist. Following RT-qPCR for all patient samples, two subgroups were
      arranged: One group in which all genes were downregulated and the second group
      with at least one gene indicated an upregulation of gene expression. Comparisons
      were made between the tumour characteristics from these two groups. Results
      suggested that carcinomas of the first group exhibited a less aggressive tumor
      biology compared with those in the second group. The present study indicated a
      novel RT-qPCR based test for tumor malignancy.

PMID- 29845201
TI  - Long non-coding RNA PVT1 promotes epithelial-mesenchymal transition via the TGF
      beta/Smad pathway in pancreatic cancer cells.
AB  - Recent studies have revealed that overexpression of long non-coding RNA (lncRNA)
      PVT1 is correlated with several types of cancer. However, its role in pancreatic
      cancer development remains to be clarified. In the present study, we found that
      PVT1 promoted the growth and the epithelial-mesenchymal transition (EMT) of
      pancreatic cancer cells. We first determined that PVT1 was upregulated in
      pancreatic cancer tissues compared with adjacent normal tissues. Knockdown of
      PVT1 inhibited viability, adhesion, migration and invasion. Furthermore, PVT1
      knockdown reduced the expression of mesenchymal markers including Snail, Slug,
      beta-catenin, N-cadherin and vimentin, while it increased epithelial marker
      expression of E-cadherin. Finally, knockdown of PVT1 inhibited the TGF-beta/Smad
      signaling, including p-Smad2/3 and TGF-beta1 but enhanced the expression of
      Smad4. In contrast, overexpression of PVT1 reversed the process. These findings
      revealed that PVT1 acts as an oncogene in pancreatic cancer, possibly through the
      regulation of EMT via the TGF-beta/Smad pathway and PVT1 may serve as a potential
      target for diagnostics and therapeutics in pancreatic cancer.

PMID- 29845202
TI  - Regulatory effects of miRNA-181a on FasL expression in bone marrow mesenchymal
      stem cells and its effect on CD4+T lymphocyte apoptosis in estrogen deficiency
      induced osteoporosis.
AB  - Post-menopausal osteoporosis is a bone formation disorder induced by estrogen
      deficiency. Estrogen deficiency facilitates the differentiation and maturation of
      osteoclasts by activating T lymphocytes. In our previous study, it was
      demonstrated that estrogen promotes bone marrow mesenchymal stem cell (BMMSC)
      induced osteoclast apoptosis through downregulation of microRNA (miR)-181a and
      subsequent Fas ligand (FasL) protein accumulation. In the present study, the
      regulatory effects of miR-181a on FasL expression in BMMSCs and the apoptotic
      effects of BMMSCs on cluster of differentiation (CD)4+T lymphocytes were
      investigated. An ovariectomized mouse model of osteoporosis (OVX) was established
      and CD4+T lymphocytes were isolated from the bones of these mice. The results
      demonstrated that the number of CD4+T lymphocytes was increased in the OVX group
      compared within the control group, thus suggesting that estrogen deficiency may
      increase CD4+T lymphocyte number. CD4+T lymphocytes were subsequently co-cultured
      with estrogen-treated BMMSCs, after which it was demonstrated that estrogen
      significantly promoted the apoptosis of CD4+T lymphocytes. Western blot analysis
      indicated that estrogen promoted the apoptosis of CD4+T lymphocytes through
      regulation of FasL expression in BMMSCs in a concentration-dependent manner.
      Finally, miR-181a was transfected into BMMSCs, which were co-cultured with CD4+T
      lymphocytes in vitro and in vivo. The results revealed that miR-181a exerted a
      negative regulatory effect on BMMSC-induced CD4+T lymphocyte apoptosis by
      regulating FasL protein expression in BMMSCs; this maybe a key mechanism
      underlying the development of estrogen deficiency-induced osteoporosis.

PMID- 29845203
TI  - Fibrinogen-like-protein 1 promotes the invasion and metastasis of gastric cancer
      and is associated with poor prognosis.
AB  - The protective role of fibrinogen-like-protein 1 (FGL1) in liver injury has been
      reported previously. However, there are few studies on FGL1 expression in gastric
      cancer (GC) tissues, and the role of FGL1 in GC remains unclear. The aim of the
      present study was to investigate the correlation between FGL1 expression and
      prognosis in GC patients. Data was downloaded from The Cancer Genome Atlas
      database, and 50 pairs of GC tissues and the corresponding non-tumor tissues were
      collected between 2008 to 2011. Furthermore, FGL1 expression was silenced in
      order to explore its role in SGC-7901 cell proliferation, invasion and migration
      using Cell Counting Kit-8, wound healing, Transwell invasion and migration
      assays, respectively. Finally, whether FGL1 is involved in epithelial-mesenchymal
      transition (EMT) regulation in SGC-7901 cells was determined by western blotting.
      The results revealed that FGL1 expression was upregulated in GC tissues, and the
      overall survival time of GC patients with high FGL1 expression levels was
      markedly shorter than that of GC patients with low FGL1 expression levels
      (P=0.005). In addition, silencing FGL1 significantly inhibited SGC-7901 cell
      proliferation, invasion and migration in vitro. Finally, western blot analyses
      indicated that knockdown of FGL1 markedly increased E-cadherin expression levels
      (P<0.01), and significantly decreased N-cadherin (P<0.01) and vimentin expression
      levels (P<0.01), thereby suggesting that FGL1 may promote EMT. These results
      indicated that FGL1 has the potential to be a predictor in GC patients as well as
      a target for the treatment of GC.

PMID- 29845204
TI  - LncRNA WWOX-AS1 inhibits the proliferation, migration and invasion of
      osteosarcoma cells.
AB  - Recently, numerous long non-coding (lnc)RNAs have been revealed as serving
      important roles in human gene regulation. Previous studies have suggested that
      aberrant expression of lncRNAs is associated with cancer progression and
      metastasis. Previous studies have also demonstrated that decreased expression of
      WW domain-containing oxidoreductase (WWOX) is associated with poor prognosis in
      numerous cancer types. However, the effect of WWOX antisense RNA 1 (WWOX-AS1) in
      the development of cancer remains unknown. The aim of the present study was to
      investigate the role of WWOX-AS1 in osteosarcoma. The expression levels of WWOX
      AS1 in human osteosarcoma cell lines and a normal osteoblastic cell line were
      investigated using reverse transcription-quantitative polymerase chain reaction
      (RT-qPCR). The results revealed that WWOX-AS1 expression was downregulated in
      osteosarcoma tissues. Furthermore, the association between WWOX-AS1 and the
      prognosis of patients with osteosarcoma was investigated using Kaplan-Meier and
      log-rank tests. The results suggested that patients exhibiting high WWOX-AS1
      expression demonstrated a greater overall survival compared with patients
      exhibiting low WWOX-AS1 expression. In addition, overexpression and knockdown of
      WWOX-AS1 was performed using transfection experiments and confirmed by RT-qPCR in
      MG63 and SAOS2 cells, respectively. The results demonstrated that WWOX-AS1 and
      WWOX expression were positively correlated. Furthermore, the results of the
      knockdown and overexpression functional experiments suggested that WWOX-AS1
      overexpression inhibited the proliferation, migration and invasion of MG63 cells,
      and knockdown of WWOX-AS1 enhanced the proliferation, migration and invasion of
      MG63 cells in SAOS2 cells. In conclusion, the results of the present study
      suggested that WWOX-AS1 may represent a potential biomarker and therapeutic
      target for the treatment of osteosarcoma.

PMID- 29845205
TI  - Effect of co-culture with amniotic epithelial cells on the biological
      characteristics of amniotic mesenchymal stem cells.
AB  - The aim of the present study was to investigate the effect of co-culture with
      amniotic epithelial cells (AECs) on the biological characteristics of amniotic
      mesenchymal stem cells (AMSCs), to compare the expression of C-X-C motif
      chemokine receptor 4 (CXCR4) in co-cultured AMSCs and to investigate the roles of
      the stromal cell-derived factor-1 (SDF-1)/CXCR4 axis in the homing and migration
      of AMSCs. AMSCs were isolated from human amniotic membranes, purified and then
      differentiated into osteoblasts and adipocytes in vitro, which was verified by
      von Kossa Staining and Oil Red O staining. Cell viability was measured by Cell
      Counting kit-8 and trypan blue assays at 24, 48 and 72 h, the expression of CXCR4
      was analyzed by immunofluorescence-based flow cytometry and reverse transcription
      quantitative polymerase chain reaction, and the migration ability of AMSCs in
      vitro was observed by a migration assay. The results demonstrated that cell
      viability (at 48 and 72 h) and survival (at 24, 48 and 72 h) in the co-culture
      and serum groups were higher compared with the serum-free group. Furthermore,
      CXCR4 mRNA and protein expression, and migration along the SDF-1 gradient, in the
      co-culture and serum-free groups were higher compared with the serum group.
      Overall, the results indicated that AMSCs co-cultured with AECs exhibited
      enhanced proliferation activity and survival rate. In conclusion, the present
      study demonstrated that co-culture of AMSCs with AECs upregulated CXCR4 on the
      surface of AMSCs and enhanced the migration ability of AMSCs in vitro. This
      result may improve the directional migration and homing ability of AMSCs, as well
      as provide a theoretical basis for the application of AMSCs in clinical practice
      as a novel strategy to increase the success of hematopoietic stem cell
      transplantation.

PMID- 29845206
TI  - MicroRNA-655 inhibits cell proliferation and invasion in epithelial ovarian
      cancer by directly targeting vascular endothelial growth factor.
AB  - In recent years, microRNAs (miRNAs/miRs) have been shown to be deregulated in
      epithelial ovarian cancer (EOC). Their deregulation has been suggested to be
      involved in EOC formation and progression through the regulation of the
      expression of numerous cancer-related genes. Hence, it is of great importance to
      further determine the detailed roles and underlying mechanisms of miRNAs involved
      in EOC and to identify novel targets for diagnosis, prognosis and treatment of
      patients with EOC. In this study, the expression of miR-655-3p (miR-655) was
      significantly downregulated in EOC tissues and four EOC cell lines. After miR-655
      was restored, functional assays revealed that cellular proliferation and invasion
      were considerably reduced in EOC. Additionally, vascular endothelial growth
      factor (VEGF) A was identified as a direct target gene of miR-655 in EOC cells.
      Furthermore, VEGF knockdown could mimic the tumour-suppressive roles of miR-655
      overexpression in EOC cells. Moreover, the introduction of VEGF abrogated the
      effects of miR-655-induced proliferation and invasion inhibition in EOC cells.
      Altogether, these findings indicated that miR-655 may inhibit EOC cell
      proliferation and invasion by repressing VEGF. Thus, the miR-655/VEGF pathway
      could serve as a novel therapeutic target for patients with EOC.

PMID- 29845207
TI  - miRNA expression profiling regulates necroptotic cell death in hepatocellular
      carcinoma.
AB  - Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer and
      is among the leading causes of cancer-related mortality worldwide. Although the
      dysregulation of microRNAs (miRNAs or miRs) has often been reported in HCC, the
      precise molecular mechanisms by which miRNAs modulate the process of
      tumorigenesis and the behavior of cancer cells are not yet clearly understood. In
      this study, we identified a novel three-miRNA signature, including miR-371-5p,
      miR-373 and miR-543, that appears to orchestrate programmed cell necrosis in HCC
      by directly targeting the caspase-8 gene (Casp-8). Our results demonstrated that
      miR-371-5p, miR-373 and miR-543 were overexpressed in HCC tissues compared with
      paired adjacent normal tissues. The upregulation of these miRNAs specifically and
      markedly downregulated the expression of Casp-8, as well as significantly
      enhanced the Z-VAD/TNF-alpha-induced necroptosis of HCC cells. By contrast, the
      selective knockdown of miRNA expression led to a significant increase in Casp-8
      levels and a marked reduction in programmed cell necrosis. Intriguingly, the
      sustained overexpression of Casp-8 reversed the pro-necroptotic effects exerted
      by miRNA mimics. Finally, a strong inverse association between the level of miR
      223 and the expression levels of nucleotide-binding oligomerization domain-like
      receptor family, pyrin domain-containing-3 inflammasome was observed in our HCC
      specimens. On the whole, the present study revealed a molecular link between the
      three-miRNA signature, comprising miR-371-5p, miR-373 and miR-543, and the
      negative necroptotic regulator Casp-8, and presents evidence for its employment
      as a novel potential diagnostic, prognostic and therapeutic target in HCC.

PMID- 29845208
TI  - Glucagon-like peptide-1 protects mouse podocytes against high glucose-induced
      apoptosis, and suppresses reactive oxygen species production and proinflammatory
      cytokine secretion, through sirtuin 1 activation in vitro.
AB  - Glucagon-like peptide-1 (GLP-1) is a gut incretin hormone that is considered to
      be a promising target for the treatment of patients with type 2 diabetes.
      However, the mechanisms underlying the protective effects of GLP-1 on diabetic
      nephropathy are yet to be fully elucidated. Sirtuin (SIRT)1 encodes a member of
      the SIRT family of proteins that serves an important role in mitochondrial
      function and is reported to be associated with the pathogenesis of chronic kidney
      disease. The present study treated mouse podocytes with various concentrations of
      D-glucose to establish a high glucose (HG)-induced model of renal injury. The
      results of a 2',7'-dichlorodihydrofluorescein diacetate assay, Annexin
      V/propidium iodide staining and ELISA demonstrated that treatment of podocytes
      with HG significantly enhanced the production of reactive oxygen species (ROS),
      promoted cell apoptosis and increased the secretion of proinflammatory cytokines,
      respectively. The cytokines increased following HG treatment included tumor
      necrosis factor-alpha, interleukin (IL)-1beta and IL-6. Notably, treatment with
      GLP-1 attenuated HG-induced increases in ROS production and podocyte apoptosis,
      which may occur via downregulation of the expression of caspase-3 and caspase-9,
      and increased expression of nephrin, podocin and SIRT1, as determined by reverse
      transcription-quantitative polymerase chain reaction and western blot analysis.
      Treatment with GLP-1 led to protective effects in podocytes that were similar to
      those of resveratrol. Furthermore, SIRT1 knockdown using short hairpin RNA
      significantly enhanced the expression of caspase-3 and caspase-9 in mouse
      podocytes, compared with normal mouse podocytes. SIRT1 knockdown with or without
      GLP-1 administration significantly decreased the expression of caspase-3 and
      caspase-9 in mouse podocytes, compared with SIRT1 knockdown mouse podocytes. In
      conclusion, the results of the present study indicated that GLP-1 may be a
      promising target for the development of novel therapeutic strategies for HG
      induced nephropathy, and may function through the activation of SIRT1.

PMID- 29845209
TI  - G protein-coupled estrogen receptor/miR-148a/human leukocyte antigen-G signaling
      pathway mediates cell apoptosis of ovarian endometriosis.
AB  - The focus of the current study was a G protein-coupled estrogen receptor
      (GPER)/microRNA (miR)-148a/human leukocyte antigen-G (HLA-G) signaling pathway in
      ovarian endometriosis. Reverse transcription-quantitative polymerase chain
      reaction was performed to analyze the changes in miR-148a expression. A MTT
      assay, flow cytometry and caspase-3/9 activity assays were performed to analyze
      cell proliferation, apoptosis and caspase-3/9 activity levels, respectively.
      Protein expression was measured using western blot analysis. In tissue samples
      from healthy controls, and patients with endometriosis and endometriosis
      associated ovarian cancer, the expression of miR-148a was lower in in
      endometriosis and EAOC samples compared with healthy controls. Overexpression of
      miR-148a using miR mimics significantly decreased proliferation, promoted
      apoptosis, increased the Bcl-2 associated X apoptosis regulator (Bax)/Bcl-2
      apoptosis regulator (Bcl-2) ratio and caspase3/9 activity, and suppressed HLA-G
      protein expression in Hs 832(C).T cells. miR-148a downregulation using miR
      inhibitor significantly increased cell viability, inhibited apoptosis, and
      reduced the Bax/Bcl-2 ratio and caspase3/9 activity, and induced HLA-G protein
      expression in Hs 832(C).T cells. The GPER inhibitor, G15, suppressed GPER protein
      expression, upregulated miR-148a expression, decreased cell proliferation,
      promoted apoptosis, increased the Bax/Bcl-2 ratio and caspase3 activity, and
      suppressed HLA-G protein expression in Hs 832(C).T cells. The findings indicate
      that GPER/miR-148a/HLA-G signaling pathway may mediates the development of
      ovarian endometriosis and may become a potential therapeutic target for the
      treatment of endometriosis.

PMID- 29845211
TI  - HSV-TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy
      inhibition by activating MAPK/ERK.
AB  - Retinoblastoma is an severe ophthalmic disease and the most common type
      intraocular malignant tumor, particularly in infants. Currently, few drugs and
      therapies are available. Gene therapy has been considered to be a potential
      treatment to cure cancer effectively and Herpes simplex virus type 1 thymidine
      kinase/ganciclovir (HSV-TK/GCV) is one type of suicide gene therapy that has been
      extensively studied. Numerous in vitro and in vivo studied have shown that this
      system can kill tumor cells, including liver and lung cancer cells. GCV is used
      as an antiviral drug, and the thymidine kinase, HSV-TK can phosphorylate GCV to
      GCV-TP, a competitive inhibitor of DNA synthesis, instead of guanine-5'
      triphosphate in the process of DNA synthesis. This process prevents DNA chain
      elongation causing cell death via apoptosis. However, the toxic effects of HSV
      TK/GCV on retinoblastoma cells remain unknown, and the molecular mechanisms of
      its therapeutic effects have not been fully elucidated. Our results suggest that
      HSV-TK/GCV can significantly cause the death of retinoblastoma cell lines, HXO
      RB44 and Y79. Further studies have reported that this cell death is induced by
      the inhibition of autophagy by activating the MAPK/ERK (mitogen-activated protein
      kinase/ERK) signaling pathway. The mTOR inhibitor Torin1 can partially block the
      toxic effects of HSV-TK/GCV on HXO-RB44 cells. The above results demonstrate that
      the mechanism undertaken by HSV-TK/GCV to exhibit therapeutic effects mechanism
      may inhibit autophagy by activating MAPK/ERK. The findings of the present study
      may provide novel insight for the exploration of HSV-TK/GCV in the treatment of
      retinoblastoma.

PMID- 29845212
TI  - Andrographolide induces degradation of mutant p53 via activation of Hsp70.
AB  - The tumor suppressor gene p53 encodes a transcription factor that regulates
      various cellular functions, including DNA repair, apoptosis and cell cycle
      progression. Approximately half of all human cancers carry mutations in p53 that
      lead to loss of tumor suppressor function or gain of functions that promote the
      cancer phenotype. Thus, targeting mutant p53 as an anticancer therapy has
      attracted considerable attention. In the current study, a small-molecule screen
      identified andrographlide (ANDRO) as a mutant p53 suppressor. The effects of
      ANDRO, a small molecule isolated from the Chinese herb Andrographis paniculata,
      on tumor cells carrying wild-type or mutant p53 were examined. ANDRO suppressed
      expression of mutant p53, induced expression of the cyclin-dependent kinase
      inhibitor p21 and pro-apoptotic proteins genes, and inhibited the growth of
      cancer cells harboring mutant p53. ANDRO also induced expression of the heat
      shock protein (Hsp70) and increased binding between Hsp70 and mutant p53 protein,
      thus promoting proteasomal degradation of p53. These results provide novel
      insights into the mechanisms regulating the function of mutant p53 and suggest
      that activation of Hsp70 may be a new strategy for the treatment of cancers
      harboring mutant p53.

PMID- 29845210
TI  - Research progress on human genes involved in the pathogenesis of glaucoma
      (Review).
AB  - Glaucoma is the leading cause of irreversible blindness globally. It is known
      that the incidence of glaucoma is closely associated with inheritance. A large
      number of studies have suggested that genetic factors are involved in the
      occurrence and development of glaucoma, and even affect the drug sensitivity and
      prognosis of glaucoma. In the present review, 22 loci of glaucoma are presented,
      including the relevant genes (myocilin, interleukin 20 receptor subunit B,
      optineurin, ankyrin repeat- and SOCS box-containing protein 10, WD repeat
      containing protein 36, EGF-containing fibulin-like extracellular matrix protein
      1, neurotrophin 4, TANK-binding kinase 1, cytochrome P450 subfamily I polypeptide
      1, latent transforming growth factor beta binding protein 2 and TEK tyrosine
      kinase endothelial) and 74 other genes (including toll-like receptor 4, sine
      oculis homeobox Drosophila homolog of 1, doublecortin-like kinase 1, RE repeats
      encoding gene, retinitis pigmentosa GTPase regulator-interacting protein, lysyl
      oxidase-like protein 1, heat-shock 70-kDa protein 1A, baculoviral IAP repeat
      containing protein 6, 5,10-methylenetetrahydrofolate reductase and nitric oxide
      synthase 3 and nanophthalmos 1) that are more closely associated with glaucoma.
      The pathogenesis of these glaucoma-associated genes, glaucomatous genetics and
      genetic approaches, as well as glaucomatous risk factors, including increasing
      age, glaucoma family history, high myopia, diabetes, ocular trauma, smoking,
      intraocular pressure increase and/or fluctuation were also discussed.

PMID- 29845214
TI  - Effect of hesperetin derivatives on the development of selenite-induced cataracts
      in rats.
AB  - Cataracts are a major cause of blindness worldwide. As anti-cataract
      pharmaceutical therapies require long-term treatment, identifying anti-cataract
      compounds that are ubiquitous in the human diet, have no adverse effects and are
      affordable, is of paramount importance. The present study focused on hesperetin
      and its derived compounds, hesperetin stearic acid ester (Hes-S) and hesperetin
      oleic acid ester (Hes-O), in order to investigate their therapeutic potential to
      treat cataracts in a selenite animal model. Thirteen-day-old Sprague Dawley rats
      were divided into 12 groups. Animals in groups 1 and 7 were subcutaneously
      injected with vehicle, those in groups 2 and 8 were administered hesperetin,
      those in groups 3 and 9 received stearic acid, those in groups 4 and 10 were
      injected with oleic acid, those in groups 5 and 11 were administered Hes-S, and
      those in groups 6 and 12 received Hes-O (10 nmol/kg body weight on days 0, 1 and
      2). Animals in groups 7 to 12 were treated with sodium selenite (20 umol/kg body
      weight given 4 h following the test compound treatment on day 0) to induce
      cataract. On day 6, rats had less severe central opacities and lower stage
      cataracts than rats in the selenite treatment-only control groups. The levels of
      glutathione (GSH) and ascorbic acid (AsA) in lenses with selenite-induced
      cataracts declined to one-third of that of controls, and the reduction in GSH and
      AsA levels was rescued following hesperetin, Hes-S or Hes-O treatment, with
      concentrations remaining to 70-80% of that of controls. However, there were no
      changes in the plasma levels of GSH and AsA following treatments. Administration
      of either hesperetin or hesperetin-derived compounds prevented the reduction of
      chaperone activity in the lens, and rats treated with Hes-S or Hes-O treatment
      had significantly greater chaperone activity than hesperetin-treated rats.
      Collectively, these results suggested that hesperetin and hesperetin-derived
      compounds may be novel drug compounds that have the potential to prevent or delay
      the onset of cataracts.

PMID- 29845213
TI  - Involvement of TIMP-1 in PECAM-1-mediated tumor dissemination.
AB  - Platelet endothelial cell adhesion molecule-1 (PECAM-1) is expressed on the
      vascular endothelium and has been implicated in the late progression of
      metastatic tumors. The activity of PECAM-1 appears to be mediated by modulation
      of the tumor microenvironment (TME) and promotion of tumor cell proliferation,
      rather than through the stimulation of tumor angiogenesis. The present study
      aimed to extend those initial findings by indicating that the presence of
      functional PECAM-1 on the endothelium promotes a proliferative tumor cell
      phenotype in vivo, as well as in tumor cell (B16-F10 melanoma and 4T1 breast
      cancer cell lines) co-culture assays with mouse endothelial cells (ECs) or a
      surrogate EC line (REN-MP). The pro-proliferative effects were mediated by
      soluble endothelial-derived factors that were dependent on PECAM-1 homophilic
      ligand interactions, but which were independent of PECAM-1-dependent signaling.
      Further analysis of the conditioned media obtained from tumor/EC and tumor/REN-MP
      co-cultures identified TIMP metallopeptidase inhibitor-1 (TIMP-1) as a PECAM-1
      regulated factor, the targeting of which in the tumor cell/REN-MP system
      inhibited tumor cell proliferation. In addition, TIMP-1 expression was decreased
      in metastatic tumors from the lungs of PECAM-1-null mice, thus providing evidence
      of the in vivo significance of co-culture studies. Taken together, these studies
      indicated that endothelial PECAM-1, through PECAM-1-dependent homophilic binding
      interactions, may induce release of TIMP-1 from the endothelium into the TME,
      thus leading to increased tumor cell proliferation.

PMID- 29845215
TI  - Pien Tze Huang ameliorates DSS-induced colonic inflammation in a mouse colitis
      model through inhibition of the IL-6/STAT3 pathway.
AB  - Interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3)
      pathway plays essential roles in the development of inflammatory diseases
      including ulcerative colitis (UC). Therefore, suppression of IL-6/STAT3 signaling
      provides a promising therapeutic strategy in UC. Pien Tze Huang (PZH), a well
      known traditional Chinese formula, has been used in China and Southeast Asia for
      centuries as a folk remedy for various inflammatory diseases. However, the
      molecular mechanisms of its anti-inflammatory effects remain to be elucidated. In
      the present study, we generated a mouse colitis model by using dextran sulfate
      sodium (DSS) and evaluated the therapeutic efficacy of PZH against UC by
      observing the clinical manifestations. We found that PZH obviously alleviated DSS
      induced colitis symptoms, including body weight loss, rectal bleeding and stool
      consistency. In addition, administration of PZH profoundly prevented DSS-induced
      colon shortening, and ameliorated colonic histopathological changes such as
      mucosal ulceration, infiltration of inflammatory cells, crypt distortion and
      hyperplastic epithelium. Moreover, PZH markedly inhibited the serum level of the
      inflammatory biomarker serum amylase A (SAA) in UC mice. Furthermore, PZH
      treatment significantly inhibited DSS-induced expression of IL-6 in colon
      tissues. Finally, the increased phosphorylation level of STAT3, induced either by
      DSS in experimental mice or by IL-6 in the differentiated human colorectal
      carcinoma cells, was significantly suppressed by PZH. These results suggest that
      the inhibition of IL-6/STAT3 signaling is a potential mechanism by which PZH is
      used in the treatment of UC.

PMID- 29845216
TI  - TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT
      signaling.
AB  - Human trophoblast cell surface antigen 2 (TROP2) has been noted to serve an
      important role in the proliferation and migration of various types of human
      cancers. However, the potential role and the molecular mechanisms of TROP2 in
      osteosarcoma (OS) remain largely unclear. In the present study, high expression
      of TROP2 in human OS tissues and cell lines was observed. Overexpression of TROP2
      promoted the proliferation and migration of OS cell lines, while TROP2 knockdown
      markedly decreased cell growth and migration. Furthermore, it was revealed that
      TROP2 overexpression significantly activated the phosphoinositide 3
      kinase/protein kinase B (PI3K/AKT) signaling pathway. Collectively, these results
      suggested that TROP2 may promote OS cell proliferation and migration via PI3K/AKT
      signaling and may serve as a novel treatment target for OS.

PMID- 29845218
TI  - Elevated TFAP4 regulates lncRNA TRERNA1 to promote cell migration and invasion in
      gastric cancer.
AB  - Cancer cell invasion and metastasis are the leading causes of the high mortality
      rates in patients with malignant tumors. There is accumulating evidence to
      indicate that dysregulated long non-coding RNAs (lncRNAs) may be involved in the
      progression of tumor invasion and metastasis. However, the regulatory mechanisms
      of the aberrant expression of lncRNAs remain largely unknown, although the roles
      of lncRNAs as drivers of tumor suppressive and oncogenic functions have appeared
      in prevalent cancer types in recent years. In the present study, we identified
      that the transcription factor, activating enhancer-binding protein 4 (TFAP4),
      acts as a key modulator of translation regulatory long non-coding RNA 1(TRERNA1),
      which has been proven to promote the invasion and metastasis of gastric cancer
      (GC) cells. We revealed that TRERNA1 was upregulated in gastric carcinogenesis
      and promoted cell migration and invasion in GC. Using bioinformatics analysis, we
      observed that there were several potential binding sites of TFAP4 in the promoter
      region of TRERNA1. The knockdown of TFAP4 significantly reduced the expression
      level of TRERNA1, whereas the ectopic expression of TFAP4 significantly increased
      the expression level of TRERNA1 in GC cell lines. Dual luciferase reporter assay
      combined with chromatin immunoprecipitation (ChIP) revealed that TFAP4
      specifically regulated the transcriptional activity of TRERNA1 by binding to the
      E-box motifs in the TRERNA1 promoter. In addition, there was a positive
      correlation between the TFAP4 and TRERNA1 expression level in clinical GC cases,
      which also indicated that TFAP4 can directly modulate the expression of TRERNA1.
      In the present study, we provide a novel potential therapeutic target and
      strategy for GC.

PMID- 29845217
TI  - Genes associated with inflammation and the cell cycle may serve as biomarkers for
      the diagnosis and prognosis of acute myocardial infarction in a Chinese
      population.
AB  - The present study aimed to identify biomarkers for the clinical diagnosis of
      acute myocardial infarction (AMI) in a Chinese population using microarray data
      collected from the Gene Expression Omnibus database under accession number
      GSE97320. This included the peripheral blood samples of three patients with AMI
      and three controls. Differentially expressed genes (DEGs) were identified using
      the limma package and protein-protein interaction networks were constructed using
      data from the Search Tool for the Retrieval of Interacting Genes database,
      followed by module analysis to screen for hub genes. Functional enrichment
      analyses were performed using the Database for Annotation, Visualization and
      Integrated Discovery. The identified genes were verified by overlapping with the
      target genes of microRNAs (miRs) known to be associated with AMI, as well as the
      DEGs identified in other AMI datasets, including GSE24519, GSE34198 and GSE48060.
      As a result, 752 DEGs (449 upregulated and 303 downregulated) were identified in
      the GSE97320 dataset. The upregulated DEGs were predicted to participate in
      inflammatory pathways, including the toll-like receptor (TLR) signaling pathway,
      including ras-related C3 botulinum toxin substrate 1 (RAC1), TLR4, C-C motif
      chemokine receptor (CCR)1; cytokine-cytokine receptor interaction, including
      signal transducer and activator of transcription (STAT)3; chemokine signaling
      pathway, including CCR10; pathways associated with cancer, including colony
      stimulating factor 3 receptor (CSF3R); and leukocyte transendothelial migration,
      including matrix metallopeptidase 9 (MMP9). The downregulated DEGs were
      associated with the cell cycle, including alstrom syndrome protein 1 (ALMS1).
      These conclusions were made following functional analysis of the genes in the
      three identified modules. MMP9, TLR4, STAT3, CCR1 and ALMS1 were regulated by miR
      21-5p, whereas RAC1 was regulated by miR-30c-5p. A comparison among the four
      datasets confirmed the roles of CSF3R and CCR10. HtrA serine peptidase 1 (HTRA1)
      was the only gene associated with both mortality and recurrence. In conclusion,
      inflammation-associated genes, including STAT3, CCR1, RAC1, MMP9, CCR10, CSF3R
      and HTRA1, as well as cell cycle-associated genes such as ALMS1, may be
      biomarkers for the diagnosis and prognosis of AMI in Chinese people.

PMID- 29845219
TI  - miR-218 promotes apoptosis of SW1417 human colon cancer cells by targeting c
      FLIP.
AB  - MicroRNAs (miRNAs) are suggested to act as either tumor oncogenes or tumor
      suppressors in different types of cancer. miRNA-218 (miR-218) is a type of short,
      non-coding RNA which is involved in gastric cancer development. In the present
      study, we evaluated the functions of miR-218 in SW1417 human colon cancer cells
      and its potential mechanisms. Following overexpression of miR-218 in human colon
      cancer cells, cell viability was determined by CKK-8 assay, cell apoptosis was
      observed using a TUNEL Kit, the expression of caspase-8, and its inhibitor
      cellular Fas-associated death domain-like interleukin-1beta-converting enzyme
      inhibitory protein (c-FLIP) was assessed by RT-PCR, western blot analysis and
      immunohistochemistry. The results indicated that miR-218 and caspase-8 expression
      was decreased while c-FLIP expression was elevated in human colon cancer tissues.
      In cultured SW1417 human colon cancer cells, miR-218 overexpression potently
      inhibited cell viability and promoted cell apoptosis. Furthermore, downregulation
      of c-FLIP expression and upregulation of caspase-8 expression were detected in
      miR-218-stimulated SW1417 cells. In addition, following the knockdown of c-FLIP
      using c-FLIP siRNA, the apoptotic effects of miR-218 on SW1417 cells were
      significantly reduced. Collectively, the present study demonstrated that miR-218
      induced the apoptosis of SW1417 cells by targeting c-FLIP. Therefore, miR-218 may
      represent a potential therapeutic method for screening and treating colon cancer.

PMID- 29845220
TI  - [Corrigendum] Heat shock protein 90/Akt pathway participates in the
      cardioprotective effect of exogenous hydrogen sulfide against high glucose
      induced injury to H9c2 cells.
AB  - Subsequently to the publication of this article, the authors have realized that
      the address affiliation for the corresponding author, Chengheng Hu, and the
      authors Longyun Peng and Xinxue Liao appeared incorrectly. These authors'
      affiliation information should have appeared as follows (the corrected address
      affiliation is featured in bold): XIAO KE1,2*, JINGFU CHEN3*, LONGYUN PENG4, WEI
      ZHANG5, YIYING YANG5, XINXUE LIAO4, LIQIU MO6, RUIXIAN GUO7, JIANQIANG FENG6,
      CHENGHENG HU4 and RUQIONG NIE2 1Department of Cardiology, Shenzhen Sun Yat-sen
      Cardiovascular Hospital, Shenzhen; 2Department of Cardiology, Sun Yat-sen
      Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong; 3Department of
      Cardiovascular Medicine and Dongguan Cardiovascular Institute, The Third People's
      Hospital of Dongguan City, Dongguan; 4Department of Cardiology and Key Laboratory
      on Assisted Circulation, Ministry of Health, The First Affiliated Hospital, Sun
      Yat-sen University; 5Department of Cardiovasology and Cardiac Care Unit (CCU),
      Huangpu Division of The First Affiliated Hospital, Sun Yat-sen University;
      6Department of Anesthesiology, Huangpu Division of The First Affiliated Hospital,
      Sun Yat-sen University; 7Department of Physiology, Zhongshan School of Medicine,
      Sun Yat-sen University, Guangzhou, Guangdong, P.R. China *Contributed equally In
      addition, the address for correspondence in the correspondence box should have
      appeared as follows: Correspondence to: Professor Chengheng Hu, Department of
      Cardiology and Key Laboratory on Assisted Circulation, Ministry of Health, The
      First Affiliated Hospital, Sun Yat-sen University, Guangdong, 58 Zhongshan 2rd
      Road, Guangzhou 510080, P.R. China E-mail: huchengheng138@163.com The authors
      regret this error in the affiliations, and apologize for any inconvenience
      caused. [the original article was published in the International Journal of
      Molecular Medicine 39: 1001-1010, 2017; DOI: 10.3892/ijmm.2017.2891].

PMID- 29845221
TI  - miR-215 promotes epithelial to mesenchymal transition and proliferation by
      regulating LEFTY2 in endometrial cancer.
AB  - Endometrial cancer (EC) is the most common gynecological tumor in developed
      countries with an increasing incidence. Left-right determination factor 2
      (LEFTY2), a suppressor of cell proliferation and tumor growth, is a negative
      regulator of EC progression. The roles of LEFTY2 are emerging; however, the
      regulatory mechanisms of its expression have not been well understood. MicroRNA
      (miR)-215 as an oncogene serves an important role in tumorigenesis by regulating
      target genes. In the present study, it was demonstrated that overexpression of
      miR-215 promoted epithelial to mesenchymal transition (EMT), colony formation and
      DNA synthesis in EC HEC-1A cells and its expression was upregulated in EC
      tissues. Using online miR target prediction software, it was revealed that LEFTY2
      is predicted as a target of miR-215. Using western blot analysis and
      immunofluorescence assays, it was demonstrated that overexpression of miR-215
      markedly downregulated LEFTY2 protein expression levels in HEC-1A cells and
      LEFTY2 protein expression was downregulated in EC tissues, which was inversely
      correlated with miR-215 expression. Furthermore, the present study indicated that
      overexpression of LEFTY2 protein promoted mesenchymal to epithelial transition
      and sensitized HEC-1A cells to cisplatin treatment. In addition, it was revealed
      that the overexpression of LEFTY2 inhibited colony formation and DNA synthesis in
      HEC-1A cells. Thus, miR-215 may promote EMT and proliferation by regulating
      LEFTY2 in EC.

PMID- 29845222
TI  - Paeonol induces the apoptosis of the SGC-7901 gastric cancer cell line by
      downregulating ERBB2 and inhibiting the NF-kappaB signaling pathway.
AB  - The purpose of the present study was to analyze the association between paeonol
      and the known genes related to gastric cancer (GC) using bioinformatics methods,
      and to investigate the role of paeonol in the potential impact on the nuclear
      factor-kappaB (NF-kappaB) signaling pathway, in order to provide a theoretical
      basis for further elucidating the effect of paeonol on cancer cells. Cell
      viability, morphology and apoptosis were detected using an MTT assay, an inverted
      microscope, and flow cytometry, respectively. The correlation between drugs and
      genes was analyzed using the Search Tool for Interactions of Chemicals (STITCH)
      gene-drug interaction network. The expression levels of related mRNA and proteins
      were determined using reverse transcription-quantitative polymerase chain
      reaction analysis and enzyme-linked immunosorbent assay. The changes in protein
      expression were examined using western blot analysis. The correlation network
      between target genes directly affected by paeonol and known GC genes was
      determined by analyzing the association between the compounds and genes recorded
      in the STITCH database. The GC-related epidermal growth factor receptor 2 (ERBB2)
      gene was at the core position of the paeonol interaction network and may be an
      important potential target gene for the effect of paeonol on cancer cells. The
      effect of paeonol on the viability of the SGC-7901 GC cell line was detected
      using an MTT assay, which showed that the inhibitory effect occurred in a time-
      and dose-dependent manner. The observations of cell morphology demonstrated that
      the cells were floating, abnormal in shape, had unclear boundaries and were
      sparse in arrangement following paeonol treatment. Flow cytometry indicated that
      paeonol significantly accelerated the apoptotic rate of the SGC-7901 GC cells.
      The examination of clinical samples suggested that ERBB2 was expressed at a high
      level in GC samples, and was significantly downregulated following the addition
      of paeonol. The western blot analysis revealed that downregulating ERBB2 affected
      the activation of the NF-kappaB signaling pathway, thereby upregulating the pro
      apoptotic factor B-cell lymphoma-associated X protein. Taken together, paeonol
      significantly downregulated ERBB2 and inhibited the activation of the NF-kappaB
      signaling pathway, thereby inhibiting the proliferation of SGC-7901 cells and
      inducing apoptosis.

PMID- 29845223
TI  - Apoptosis induced by 9,11-dehydroergosterol peroxide from Ganoderma Lucidum
      mycelium in human malignant melanoma cells is Mcl-1 dependent.
AB  - 9,11-Dehydroergosterol peroxide [9(11)-DHEP] is an important steroid from
      medicinal mushroom, which has been reported to exert antitumor activity in
      several tumor types. However, the role of 9(11)-DHEP toward the malignant
      melanoma cells has not been investigated. In the present study, the steroid from
      Ganoderma lucidum was purified on a submerged culture, and its antitumor
      mechanisms on A375 human malignant melanoma cells was investigated by MTT, flow
      cytometry and western blotting. The studies demonstrated that apoptotic
      mechanisms of the steroid were caspase-dependent and mediated via the
      mitochondrial pathway. The steroid did not cause significant changes in the
      expression levels of B-cell lymphoma 2 (Bcl-2) family proteins, Bcl-2-like
      protein 11, p53 upregulated modulator of apoptosis, Bcl-2-associated X protein,
      BH3 interacting-domain death agonist, Bcl-2-associated death promoter and Bcl-2,
      but it significantly downregulated induced myeloid leukemia cell differentiation
      protein Mcl-1 (Mcl-1) in melanoma cells, suggesting the key role of Mcl-1 in
      regulating apoptosis of melanoma cells induced by the steroid. These properties
      of 9(11)-DHEP advocate its usage as supplements in human malignant melanoma
      chemoprevention. The present study also suggests that mycelium of G. lucidum has
      a potential for producing bioactive substances and extracts with applications in
      medicine.

PMID- 29845224
TI  - Let-7d inhibits colorectal cancer cell proliferation through the CST1/p65
      pathway.
AB  - Cystatin SN (cystatin 1, CST1) is a member of the cystatin superfamily which
      inhibits the proteolytic activity of cysteine proteases. CST1 is a tumor
      biomarker that provides useful information for the diagnosis of esophageal,
      gastric and colorectal carcinomas. MicroRNAs (miRNAs or miRs) play an important
      role in tumor cell proliferation. However, the exact role of let-7d and CST1 in
      colon cancer remains unknown. The aim of this study was to assess whether let-7d
      inhibits colorectal carcinogenesis through the CST1/p65 pathway, and determine
      whether it may be used as a potential target for clinical therapy. Microarray
      analysis of mRNAs extracted from colon cancer and normal tissues was performed.
      The results of gene expression microanalysis revealed that CST1 expression was
      upregulated in colon cancer compared with normal tissues. In addition, the
      upregulation of CST1 expression and the downregulation of let-7d expression in
      patients with colon cancer and in several colorectal cancer cell lines were
      confirmed by reverse transcription-quantitative PCR (RT-qPCR),
      immunohistochemistry and western blot analysis. In addition, siRNA targeting CST1
      (CST1-siRNA) and let-7d-mimics were used in the HCT116 cells, and the results
      revealed that CST1 and let-7d played a role in colorectal cancer cell
      proliferation. Let-7d inhibited colorectal carcinogenesis through the CST1/p65
      pathway. Thus, the findings of the present study indicate that CST1 may be a
      potential target for the future clinical therapy of colorectal cancer.

PMID- 29845225
TI  - WAVE3 promotes proliferation, migration and invasion via the AKT pathway in
      pancreatic cancer.
AB  - Alterations in Wiskott-Aldrich syndrome protein family verprolin-homologous
      protein 3 (WAVE3) expression play various roles in certain types of cancer.
      However, the roles of WAVE3 expression in pancreatic cancer remain unknown. The
      present retrospective study demonstrated that WAVE3 expression was higher in
      cancerous pancreatic tissues than in non-neoplastic tissues. Moreover, WAVE3
      overexpression was related to lymphatic metastasis, a poor differentiation and
      high pre-operative CA19-9 levels and was an adverse prognostic factor for
      patients with pancreatic cancer. In vitro, the knockdown of WAVE3 inhibited the
      proliferative, migratory and invasive potential of pancreatic cancer cells and
      promoted cell apoptosis. Western blot analysis demonstrated that WAVE3 influenced
      the protein kinase B (PBK/AKT) pathway by suppressing the expression of pyruvate
      dehydrogenase kinase isoform 2 (PDK2) and then negatively inhibiting the
      phosphorylation of Ser473 on AKT. Furthermore, the expression of AKT pathway
      downstream proteins [certain epithelial-mesenchymal transition (EMT)-related
      proteins, p53, Bcl-2 and cyclin D1] was accordingly altered. Taken together, our
      findings suggest that WAVE3 influences cell proliferation, migration and invasion
      via the AKT pathway, and targeting WAVE3 and/or the AKT pathway may potentially
      serve as a treatment strategy for pancreatic cancer.

PMID- 29845226
TI  - Downregulation of microRNA-449a-5p promotes esophageal squamous cell carcinoma
      cell proliferation via cyclin D1 regulation.
AB  - Aberrant microRNA-449a (miR-449a-5p) expression has been demonstrated to be
      associated with the development of various cancer types. However, the effect of
      miR-449a-5p on esophageal squamous cell carcinoma (ESCC) cell proliferation
      remains unknown. The present study aimed to determine whether miR-449a-5p may
      regulate ESCC cell proliferation via negative regulation of cyclin D1. Reverse
      transcription quantitative-polymerase chain reaction was used to measure the
      expression of miR-449a-5p in ESCC tissues and cells. Western blot was performed
      to analyze the protein level of cyclin D1. The proliferation of ESCC cells was
      determined by MTT and clone formation assay. Paired ESCC and adjacent normal
      esophageal squamous tissues were collected from patients with ESCC. It was
      demonstrated that miR-449a-5p expression was reduced, whereas cyclin D1
      expression was increased in ESCC tissues compared with adjacent normal tissues.
      Proliferation was investigated in vivo using the ESCC cell line Eca-190. miR-449a
      5p inhibitor transfection facilitated the proliferation of Eca-109 cells. By
      contrast, transfection with miR-449a-5p mimics inhibited Eca-109 cell
      proliferation. Furthermore, it was confirmed that miR-449a-5p directly bound to
      the 3'-untranslated region of cyclin D1. Transfection with cyclin D1 small
      interfering RNA reversed the effects of the miR-449a-5p inhibitor on Eca-109 cell
      proliferation. In conclusion, miR-449a-5p may control ESCC proliferation through
      the negative regulation of cyclin D1 expression.

PMID- 29845227
TI  - Application of an improved targeted next generation sequencing method to diagnose
      non-syndromic mental retardation in one step: A case report.
AB  - The genetic basis of congenital mental retardation includes chromosomal anomalies
      and single gene mutations. In addition to chromosome microarray analysis, next
      generation sequencing (NGS) and Sanger sequencing have additionally been applied
      to identify single gene mutations. However, no methods exist to identify the
      cause of an anomaly in one step. The present study applied an improved targeted
      NGS method to diagnose an 8-year-old Chinese Han female with mental retardation
      in one step. The microdeletion 17p11.2 was successfully detected by the improved
      targeted NGS and no single gene mutations were identified. The same microdeletion
      was verified using low coverage whole-genome sequencing. Fertility guidance was
      also given to the patient's parents. In the present study, an improved targeted
      NGS method was applied to diagnose non-syndromic mental retardation of unknown
      cause in one step. This improved method has the potential to be developed into a
      screening panel for the effective diagnosis of genetic abnormalities in non
      syndromic mental retardation and other congenital anomalies.

PMID- 29845228
TI  - Cancer stem cells and hypoxia-inducible factors (Review).
AB  - Cancer stem cells (CSCs), also known as tumor-initiating cells, are a
      subpopulation of tumor cells that exhibit properties similar to those of normal
      stem cells. Oxygen is an important regulator of cellular metabolism; hypoxia
      inducible factors (HIFs) mediate metabolic switches in cells in hypoxic
      environments. Hypoxia clearly has the potential to exert a significant effect on
      the maintenance and evolution of CSCs. Both HIF-1alpha and HIF-2alpha may
      contribute to the regulation of cellular adaptation to hypoxia and resistance to
      cancer therapies. This review provides an overview of the roles of HIFs in CSCs.
      HIF-1alpha and HIF-2alpha have significant prognostic and predictive value in the
      clinic and the concept of personalized medicine should be applied in designing
      clinical trials for HIF inhibitors.

PMID- 29845229
TI  - Knockdown of GA-binding protein subunit beta1 inhibits cell proliferation via p21
      induction in renal cell carcinoma.
AB  - Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancer.
      In the present study, bioinformatics tools were systematically used to
      investigate the potential upstream effector involved in the progression of ccRCC.
      Using the Gene Expression Omnibus database and Library of Integrated Network
      based Cellular Signatures L1000 platform, it was identified that GA-binding
      protein subunit beta1 (GABPB1) was a potential effector gene. GABPB1 is a
      transcription factor subunit and its function in ccRCC is unclear. Elevated
      expression of GABPB1 mRNA in ccRCC was also observed in other clinical datasets
      from the Oncomine database. Following reverse transcription-quantitative
      polymerase chain reaction and western blot analysis, the ccRCC 786-O and A498
      cell lines showed higher expression levels of GABPB1 than HK-2, a normal kidney
      cell line. Knockdown of GABPB1 in the 786-O and A498 cells significantly
      decreased the ability to form colonies by inducing the expression of p21Waf/Cip1.
      SurvExpress database analysis indicated that a higher expression of GABPB1 was
      associated with poor survival outcome in patients with renal cancer. These
      findings imply that GABPB1 serves an important role in the progression of ccRCC.

PMID- 29845230
TI  - Pulsed electromagnetic fields alleviate streptozotocin-induced diabetic muscle
      atrophy.
AB  - Diabetic muscle atrophy causes a reduction of skeletal muscle size and strength,
      which affects normal daily activities. However, pulsed electromagnetic fields
      (PEMFs) can retard the atrophy of type II fibers (ActRIIB) in denervated muscles.
      Therefore, the purpose of the present study was to determine whether PEMFs can
      alleviate streptozotocin (STZ)-induced diabetic muscle atrophy. To do this, 40
      Sprague-Dawley (SD) rats were randomly divided into four groups (n=10 per group):
      The normal control group (NC; nondiabetic rats without treatment); the diabetic
      mellitus group (DM; STZ-induced rats without treatment); the diabetic insulin
      treated group (DT; diabetic rats on insulin treatment, 6-8 U/d twice a day for 6
      weeks) as a positive control; and the diabetic PEMFs therapy group (DP; diabetic
      rats with PEMFs exposure treatment, 15 Hz, 1.46 mT, 30 min/day for 6 weeks). Body
      weight, muscle strength, muscle mass and serum insulin level were significantly
      increased in the DP group compared with the DM group. PEMFs also decreased the
      blood glucose level and altered the activity of metabolic enzymes. PEMFs
      significantly increased the cross-sectional area of muscle fiber. In addition,
      PEMFs significantly activated protein kinase B (Akt) and mammalian target of
      rapamycin (mTOR), and inhibited the activity of myostatin (MSTN), ActRIIB and
      forkhead box protein O1 (FoxO1) compared with the DM group. Thus indicating that
      the Akt/mTOR and Akt/FoxO1 signaling pathways may be involved in the promotion of
      STZ-induced diabetic muscle atrophy by PEMFs. The results of the present study
      suggested that PEMFs stimulation may alleviate diabetic muscle atrophy in the STZ
      model, and that this is associated with alterations in multiple signaling
      pathways in which MSTN may be an integral factor. MSTN-associated signaling
      pathways may provide therapeutic targets to attenuate severe diabetic muscle
      wasting.

PMID- 29845231
TI  - Identification of key gene networks associated with fracture healing using
      alphaSMA-labeled progenitor cells.
AB  - The aim of the present study was to investigate the key gene network in fracture
      healing. The dataset GSE45156 was downloaded from the Gene Expression Omnibus.
      Differentially expressed genes (DEGs) were identified using the linear models for
      microarray data package of Bioconductor. Subsequently, Gene Ontology (GO)
      functional and Kyoto Encyclopedia of Genes and Genomes pathway enrichment
      analyses were conducted for DEGs in day 2 and 6 fractured samples via the
      Database for Annotation, Visualization and Integrated Discovery. Furthermore,
      protein-protein interactions (PPIs) of DEGs were analyzed and a PPI network was
      constructed. A total of 774 and 1,172 DEGs were identified in day 2 and 6
      fractured samples, respectively, compared with unfractured controls. Of the DEGs
      in day 2 and 6 fractured samples, various upregulated DEGs, including protein
      kinase C alpha (Prkca) and B-cell lymphoma antagonist/killer 1 were significantly
      enriched in GO terms associated with cell death, and certain downregulated DEGs,
      including fms-related tyrosine kinase 1 (Flt1), nitric oxide synthase 3 (Nos3),
      bone morphogenetic protein 4 (Bmp4) and Notch1 were enriched in GO terms
      associated with angiogenesis. Furthermore, a series of downregulated DEGs were
      enriched in the Notch signaling pathway, including hes family bHLH transcription
      factor 1 and Notch1. Certain DEGs had a high degree and interacted with each
      other, including Flt1, Nos3, Bmp4 and Notch1, and Prkca and ras-related C3
      botulinum toxin substrate 3. The up and downregulated DEGs may exert critical
      functions by interactively regulating angiogenesis or apoptosis.

PMID- 29845232
TI  - Upregulation of microRNA-24 causes vasospasm following subarachnoid hemorrhage by
      suppressing the expression of endothelial nitric oxide synthase.
AB  - MicroRNA (miR)-24 has been reported to associate with various diseases by acting
      on different signaling pathways. The present study aimed to elucidate the
      association between miR-24 expression levels and vasospasm following subarachnoid
      hemorrhage (SAH), and its underlying mechanism. An miR online database was
      searched, identifying endothelial nitric oxide synthase (NOS3) as a potential
      target gene of miR-24. A luciferase reporter assay performed to investigate the
      regulatory association between miR-24 and NOS3 revealed that miR-24 bound to the
      NOS3 3' untranslated region and inhibited NOS3 expression. Reverse transcription
      quantitative polymerase chain reaction and western blot analysis were performed
      to investigate the miR-24 and NOS3 expression levels in samples from patients
      with SAH, and demonstrated a negative correlation between the two. In addition,
      miR-24 expression levels were increased in SAH patients with vasospasm compared
      with those without, whereas the opposite results were observed for NOS3. Vascular
      smooth muscle cells (VSMCs) transfected with an miR-24 inhibitor exhibited
      increased expression levels of NOS3, whereas those transfected with an miR-24
      mimic or NOS3 small interfering RNA exhibited reduced expression levels of NOS3,
      compared with the control. These results indicated a negative regulatory
      association between miR-24 and NOS3. Downregulation of NOS3 may induce vasospasm
      following SAH, which may be due to the upregualtion of miR-24 in VSMCs.

PMID- 29845233
TI  - Matrine exerts inhibitory effects in melanoma through the regulation of miR-19b
      3p/PTEN.
AB  - Matrine, one of the main alkaloid components extracted from the traditional
      Chinese herb, Sophora flavescens Ait, has various pharmacological effects, and
      has been reported to exert antitumor activity in melanoma. In the current study,
      the molecular mechanisms underlying the inhibitory effects of matrine were
      investigated in melanoma cell line. It was initially confirmed that matrine
      inhibited proliferation, invasion and induced apoptosis in human A375 and SK-MEL
      2 melanoma cell lines in vitro. Subsequently, reverse transcription-quantitative
      polymerase chain reaction (RT-qPCR) analysis demonstrated that the expression of
      microRNA (miR)-19b-3p was significantly increased in melanoma cells and was
      downregulated by treatment with matrine. Furthermore, downregulated miR-19b-3p
      exerted effects similar to 500 ug/ml matrine on cell proliferation, invasion and
      apoptosis. Phosphatase and tensin homolog (PTEN) mRNA was identified as a direct
      target of miR-19b-3p through bioinformatics analysis and a dual-luciferase
      reporter assay. Additionally, western blotting and RT-qPCR analysis demonstrated
      that the expression of PTEN protein and mRNA were increased by the treatment with
      matrine. Furthermore, silencing of PTEN expression reversed the effects of
      matrine and miR-19b-3p downregulation in A375 and SK-MEL-2 cells. Taken together,
      the results indicated that matrine may suppress cell proliferation and invasion
      and induce cell apoptosis partially via miR-19b-3p targeting of PTEN.

PMID- 29845234
TI  - Quercetin protects against ox-LDL-induced injury via regulation of ABCAl, LXR
      alpha and PCSK9 in RAW264.7 macrophages.
AB  - Quercetin is a flavonoid that has anti-inflammatory, anti-oxidant and lipid
      metabolic effects. It has also been reported to reduce the risk of cardiovascular
      disease. The present study measured the effects of quercetin on the expression of
      ATP-binding cassette transporter 1 (ABCAl), ATP-binding cassette sub-family G
      member 1 (ABCG1), liver X receptor-alpha (LXR-alpha), proprotein convertase
      subtilisin/kexin type 9 (PCSK9), p53, p21 and p16 induced by oxidized low density
      lipoprotein (ox-LDL). RAW264.7 macrophages were exposed to ox-LDL with or without
      20 umol/l quercetin and cell proliferation and senescence were quantified using
      beta-gal staining. Superoxide dismutase (SOD), malondialdehyde (MDA) and lipid
      droplets were measured in the cytoplasm using oil red staining, while
      intracellular and total cholesterol (TC) were measured using filipin staining and
      a TC kit. Immunofluorescent studies and western blot analysis were performed to
      quantify the expression of ABCAl, ABCG1, LXR-alpha, PCSK9, p53, p21 and p16.
      Quercetin increased RAW264.7 cell viability and reduced lipid accumulation,
      senescence, lipid droplets, intracellular cholesterol and TC. It was concluded
      that quercetin inhibits ox-LDL-induced lipid droplets in RAW264.7 cells by
      upregulation of ABCAl, ABCG1, LXR-alpha and downregulation of PCSK9, p53, p21 and
      p16.

PMID- 29845235
TI  - Rosuvastatin relieves myocardial ischemia/reperfusion injury by upregulating PPAR
      gamma and UCP2.
AB  - The present study aimed to investigate whether pretreatment with rosuvastatin
      (RS) can provide cardioprotection in a myocardial ischemia/reperfusion (MI/R)
      model. The protective effect of RS on myocardial oxygen-glucose
      deprivation/reperfusion (OGD/R) injury was also evaluated by upregulating
      peroxisome proliferator-activated receptor-gamma (PPAR-gamma). In the present
      study, MI/R model was established and activities of superoxide dismutase (SOD),
      lactate dehydrogenase (LDH), creatine kinase-muscle/brain (CK-MB),
      malondialdehyde (MDA), and troponin I/T were measured. The infarct size was
      measured using Evans blue staining and cell viability was measured by MTT assay.
      Reactive oxygen species (ROS) levels were assessed by flow cytometry. Caspase-9,
      cytochrome c (cyt c), mitochondrial uncoupling protein 2 (UCP2) and PPAR-gamma
      expression levels were detected by reverse transcription-quantitative polymerase
      chain reaction and western blotting. The results indicated that RS increased SOD
      activity, and decreased LDH, CK-MB, MDA and troponin I/T activities. The effect
      of RS was reversed by atractyloside (ATR). RS inhibited myocardial infarct size,
      downregulated expression of caspase-9 and cyt c and upregulated expression of
      UCP2 and PPAR-gamma by inhibiting ATR. Furthermore, the results indicated that RS
      promoted cardiomyocyte viability, inhibited LDH release, reduced ROS production,
      decreased expression of caspase-9 and cyt c, and increased expression of UCP2 and
      PPAR-gamma following OGD/R damage. Therefore, the present study demonstrated that
      RS protects primary myocardial cells against OGD/R injury by regulating PPAR
      gamma and UCP2. RS may be a promising therapeutic agent for treatment of MI/R
      injury.

PMID- 29845236
TI  - Expression of microRNA-377 and microRNA-192 and their potential as blood-based
      biomarkers for early detection of type 2 diabetic nephropathy.
AB  - The increased incidence of diabetic nephropathy (DN) in type 2 diabetes (T2D)
      requires novel markers for the early detection of DN. Previously, microRNAs
      (miRs) have been demonstrated to be promising disease biomarkers. The present
      study evaluated the biomarker potential of DN-associated miR-377 and miR-192 in
      the early stages of DN. The study included 85 participants: 55 patients with T2D
      (30 without DN and 25 with DN) and 30 healthy controls. The patients with T2D
      were classified according to albumin-to-creatinine ratio and were split into
      three groups: Normoalbuminuric group (n=30), microalbuminuric group (n=15) and
      macroalbuminuric group (n=10). Reverse transcription-quantitative polymerase
      chain reaction analysis was used to evaluate blood miR expression. It was
      observed that there was higher miR-377 expression and lower miR-192 expression in
      T2D patients with and without DN compared with healthy controls (P<0.05). miR-377
      was higher in the normoalbuminuric group and gradually increased in the
      microalbuminuric and macroalbuminuric groups (P<0.05), whereas miR-192 was lower
      in the macroalbuminuric group compared with the normoalbuminuric group (P<0.05).
      Regression analysis revealed direct associations between the two miRs and
      albuminuria (P<0.05). miR-377 was independently associated with DN risk, even
      following multivariable adjustment, and albuminuria was the only predictor of miR
      377 (P<0.001). In discriminating overall patients from healthy subjects, ROC
      analysis revealed areas under the curve (AUCs) of 0.851 for miR377 and 0.774 for
      miR-192 (P<0.001). In discriminating the normoalbuminuric group from the
      microalbuminuric/macroalbuminuric groups, the AUCs were 0.711 (P=0.008) and 0.70
      (P=0.049) for miR-377 and miR-192, respectively. In patients with
      microalbuminuria and macroalbuminuria, miR-377 correlated positively with
      albuminuria and negatively with renal function, whereas miR-192 correlated
      negatively with albuminuria and positively with renal function (P=0.001), and the
      two miRs were correlated with known risk factors of DN (P<0.05). The results
      suggested that blood-based miR-377 and miR-192 may serve as potential biomarkers
      for early detection of DN. Further validation studies are required with larger
      sample sizes.

PMID- 29845237
TI  - Downregulation of miR-637 promotes proliferation and metastasis by targeting
      Smad3 in keloids.
AB  - Keloids are a type of abnormal scar tissue. MicroRNAs (miRNAs) exhibit a pivotal
      role in the regulation of cell proliferation and metastasis of keloids. miRNA
      microarray revealed that miR-637 was one of the most frequently altered miRNAs in
      keloids. Furthermore, up-regulation of miR-637 inhibited cell proliferation and
      metastasis by targeting mothers against decapentaplegic homolog (Smad)3, one of
      the important proteins that affects the formation of keloids. Further studies
      demonstrated that miR-637 regulated the proliferation and metastasis of human
      keloid fibroblast (HKF) cells by mediating the Smad3 signaling pathway. Overall,
      the present findings suggest that miR-637 may be a promising therapeutic target
      in keloids.

PMID- 29845238
TI  - Matrine inhibits prostate cancer via activation of the unfolded protein
      response/endoplasmic reticulum stress signaling and reversal of epithelial to
      mesenchymal transition.
AB  - Prostate cancer is the second most commonly diagnosed malignancy and the sixth
      global primary cause of malignancy-associated fatality. Increased invasiveness
      and motility in prostate cancer cells are associated with ubiquitin proteasome
      system-regulated epithelial to mesenchymal transition (EMT). Impairment of the
      endoplasmic reticulum (ER) causes ER stress due to the accumulation of unfolded
      proteins and altered cell survival. In the current study, the effect and
      mechanism of matrine on cell apoptosis, viability, migration and invasion of
      human prostate cancer cells in vivo and in vitro through the unfolded protein
      response (UPR)/ER stress pathway were investigated. Matrine inhibited proteasomal
      chymotrypsin-like (CT-like) activity in the prostate carcinoma cellular
      proteasome. Upregulated vimentin and N-cadherin and downregulated E-cadherin were
      also observed in vitro and in vivo. In vitro analyses showed that matrine
      repressed cell motility, viability and invasion, arrested the cell cycle at the
      G0/G1 phase and induced prostate cancer cell apoptosis. Furthermore, matrine
      activated the UPR/ER stress signaling cascade in prostate cancer cells and tumor
      tissues of xenograft-bearing nude mice. Results also demonstrated that the anti
      apoptotic protein Bcl-2 was downregulated, the pro-apoptotic protein Bak was
      upregulated and the cell growth and cell cycle-related proteins c-Myc, Cyclin B1,
      Cyclin D1 and CDK1 were downregulated. Moreover, matrine inhibited tumor growth
      and Ki-67 expression in xenograft-bearing nude mice. To the best of our
      knowledge, the present study indicated for the first time that matrine exerted
      marked anticancer functions in human prostate carcinoma in vivo and in vitro
      through activation of the proteasomal CT-like activity inhibition mediated by the
      UPR/ER stress signaling pathway.

PMID- 29845239
TI  - Identification of a mutL-homolog 1 mutation via whole-exome sequencing in a
      Chinese family with Gardner syndrome.
AB  - Gardner syndrome (GS), a variant of familial adenomatous polyposis, is a rare
      genetic disorder with autosomal dominant inheritance, characterized by the
      presence of multiple intestinal polyps, multiple osteomas, dental abnormalities
      and soft tissue tumors. To date, only a few gene mutations have been demonstrated
      to be responsible for GS. To explore potential unknown mutations responsible for
      GS, the present study used whole-exome sequencing of two affected individuals
      from a family with GS to identify a candidate mutation in mutL-homolog (MLH)1.
      The two patients with GS were diagnosed based on a combination of clinical
      features, family history, physical examinations and cone-beam computed
      tomographic imaging. Through whole-genome sequencing, the present study
      subsequently identified a missense mutation in MLH1
      (NM_000249.3:p.Tyr379Ser/c.1136A>C), which was further confirmed by Sanger
      sequencing. Furthermore, the amino acid residue p.Tyr379 was identified to be
      highly conserved among different species through sequence alignment with
      ClustalW2. In conclusion, the results identified for the first time a MLH1
      missense mutation (NM_000249.3:p.Tyr379Ser/c.1136A>C) in a Chinese family with
      GS, thus broadening the range of mutated genes associated with GS. This
      highlights the value of whole-exome sequencing in identifying disease mutations
      in a family.

PMID- 29845240
TI  - Caspase-9 was involved in cell apoptosis in human dental pulp stem cells from
      deciduous teeth.
AB  - As one type of adult stem cells (ASCs), human dental pulp stem cells (HDPSCs)
      have several properties, including high proliferation rate, self-renewal
      capability, and multi-lineage differentiation. However, the apoptotic mechanism
      underlying the development of dental pulp cells remains unclear. In the present
      study, a significant increase of apoptosis was observed in HDPSCs from the
      deciduous teeth compared with that from adult permanent teeth. In addition, the
      occurrence of cytochrome c expression and mitochondrial-mediated apoptosis
      pathway activity in HDPSCs were confirmed by quantitative polymerase chain
      reaction, and western blotting. Although caspase-8 and caspase-9 showed higher
      expression in deciduous teeth than in adult permanent teeth, only the knockdown
      of caspase-9 via RNA interference in HDPSC cells exhibited a significant
      reduction in apoptosis, and caspase-3 expression and activity. All these results
      revealed that caspase-9 and activated caspase-3 predominantly regulates cell
      apoptosis in HDPSCs from deciduous teeth.

PMID- 29845241
TI  - Water-soluble nano-pearl powder promotes MC3T3-E1 cell differentiation by
      enhancing autophagy via the MEK/ERK signaling pathway.
AB  - Nacre (mother of pearl) is a bioactive material capable of facilitating
      osteoblast proliferation and differentiation; however, further investigation into
      the mechanism underlying the effects of nacre on the stimulation of bone
      differentiation is required. The present study aimed to elucidate the effects of
      water-soluble nano-pearl powder (WSNNP) on osteoblast differentiation and to
      examine the underlying mechanisms. A MTT assay revealed that WSNNP (10, 25 and 50
      ug/ml) may stimulate the viability of preosteoblastic MC3T3-E1 cells and 50 ug/ml
      WSNNP exhibited the maximum stimulatory effect. Furthermore, WSNNP significantly
      enhanced the protein expression levels of differentiation markers, including
      collagen I, runt-related transcription factor 2 (RUNX2), secreted phosphoprotein1
      (SPP1) and alkaline phosphatase (ALP) in a dose-dependent manner, which indicated
      that WSNNP may promote osteoblast differentiation. Subsequently, whether
      autophagy serves a role in WSNNP-mediated differentiation of osteoblasts was
      investigated via western blotting and immunofluorescence. The results of the
      present study demonstrated that WSNNP treatment significantly evoked the
      expression of autophagy markers, including microtubule-associated light chain 3
      (LC3)II/I, Beclin1 and autophagy-related 7 (ATG7), whereas the autophagy
      inhibitor 3-methyladenine significantly inhibited WSNNP-induced osteoblast
      differentiation. Furthermore, the role of WSNNP on the potential signaling
      pathways that activate autophagy was investigated. The present study reported
      that WSNNP may significantly upregulate the mitogen-activated protein kinase
      kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway.
      Treatment with the MEK inhibitor U0126 significantly inhibited the protein
      expression levels of WSNNP-induced differentiation markers, including collagen I,
      RUNX2, SPP1 and ALP, and autophagy markers, including LC3II/I, Beclin1 and ATG7.
      Therefore, the findings of the present study suggested that WSNNP may contribute
      to osteoblast differentiation by enhancing autophagy via the MEK/ERK signaling
      pathway, thus suggesting a novel direction for optimizing the biological
      materials in bone implants.

PMID- 29845242
TI  - Diagnosis of polyglutamine spinocerebellar ataxias by polymerase chain reaction
      amplification and Sanger sequencing.
AB  - Spinocerebellar ataxia (SCA) is a group of genetic diseases of the nervous system
      with genetic and clinical heterogeneity. SCA is often caused by an expanded CAG
      repeat sequence in the encoding protein. Genetic testing is necessary to diagnose
      and classify the types of SCA. Next-generation DNA sequencing usually generates a
      high error rate for insertion or deletion mutations, so it is unhelpful for
      classifying the types of SCA. In the present study, a Chinese SCA pedigree was
      preliminarily diagnosed with SCA1 using polymerase chain reaction (PCR)
      amplification. The propositus and his three younger siblings were diagnosed with
      SCA1 as a result of the identification of the length of the expanded CAG repeat
      sequence in the ATXN1 gene performed using Sanger sequencing. The current study
      presents a convenient and efficient method to identify causative mutations for
      polyglutamine SCA using PCR amplification followed by Sanger sequencing.

PMID- 29845243
TI  - Reduction in activating transcription factor 4 promotes carbon tetrachloride and
      lipopolysaccharide/D-galactosamine-mediated liver injury in mice.
AB  - Although activating transcription factor 4 (ATF4) is involved in the regulation
      of numerous biological functions, whether ATF4 has a direct role in liver injury
      is unknown. The aim of the present study was to investigate the role of ATF4 in
      liver injury using mouse models. The results revealed that ATF4 protein is
      expressed markedly higher in the mouse liver when in comparison with other
      tissues. Notably, tunicamycin treatment, an endoplasmic reticulum (ER) stress
      inducer, induced the phosphorylation of eukaryotic translation initiation factor
      2alpha (eIF2alpha), but decreased ATF4 protein levels in the mouse liver. This
      suggested an unconventional regulation pattern of ATF4 protein not associated
      with ER stress or eIF2alpha. In addition, it was also observed that the liver
      levels of ATF4 protein were significantly reduced upon chronic liver injury
      induced by carbon tetrachloride (CCl4). ATF4 protein was also decreased in acute
      liver injury induced by lipopolysaccharide (LPS) plus D-galactosamine (D-GalN).
      Furthermore, the results revealed that knockdown of ATF4 by injecting ATF4
      targeting Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)
      CRISPR associated protein 9 plasmids exacerbated CCl4 and LPS/D-GalN-induced
      liver injury as demonstrated by elevated serum aspartate transaminase and alanine
      aminotransferase levels. ATF4 suppression also enhanced CCl4 and LPS/D-GalN
      mediated c-Jun N-terminal kinase activation. By contrast, ATF4 overexpression
      alleviated CCl4 and LPS/D-GalN-induced liver injury. Taken together, these
      observations suggested that ATF4 may serve a protective role in the mouse liver.

PMID- 29845244
TI  - Bushen recipe and its disassembled prescriptions inhibit inflammation of liver
      injury associated with Concanavalin A through Toll-like receptor 3/9 signaling
      pathway.
AB  - The aim of the present study was to explore the effect of Bushen recipe and its
      disassembled prescriptions on liver injury and chronic hepatitis B. Liver injury
      was induced in normal and hepatitis B virus (HBV)-transgenic mice through
      injection of Concanavalin A, followed by treatment with Bushen recipe and its
      disassembled prescriptions including the Bushen-yang, the Bushen-yin and the
      QingHua groups as well as the GanYanLing group (positive control). Subsequently,
      their liver function indexes were investigated by a microplate method and liver
      sections were blindly evaluated using an optical microscope by a pathologist.
      Subsequently, the activation state of Toll-like receptor (TLR)3/9 signaling
      pathway in liver tissues was analyzed by western blotting. Additionally, the
      inflammatory factors produced following liver injury in peripheral blood were
      detected via ELISA. Following intervention with the Bushen recipe and its
      disassembled prescriptions, the liver function indexe alanine aminotransferase
      had declined, whereas cholinesterase increased. The pathological alterations of
      liver tissue in HBV transgenic mice were reversed by Bushen recipe and its
      disassembled prescriptions. In addition, the TLR3/9 signaling pathway in liver
      tissues of HBV transgenic mice was inhibited and inflammatory factors such as
      interleukin (IL)-6, IL-1, tumor necrosis factor-alpha and interferon-gamma were
      reduced significantly. In conclusion, the present study demonstrated that Bushen
      recipe and its disassembled prescriptions repaired liver injury induced by
      Concanavalin A through inhibition of TLR3/9 signaling pathway.

PMID- 29845245
TI  - Downregulation of CUEDC2 prevents doxorubicin-induced cardiotoxicity in H9c2
      cells.
AB  - Treatment with doxorubicin (DOX), which is an effective anticancer agent, is
      limited by cardiotoxicity. CUE domain-containing 2 (CUEDC2) serves a role in
      numerous cellular processes. The present study aimed to elucidate the potential
      function of CUEDC2 in DOX-induced cardiotoxicity. Cell Counting kit-8 assay
      demonstrated that DOX induced cytotoxicity of H9c2 cells in a dose-dependent
      manner. Flow cytometry demonstrated that downregulation of CUEDC2 reduced the
      levels of DOX-induced reactive oxygen species. Furthermore, compared with in the
      DOX-treated group, the activity of superoxide dismutase was increased in the DOX
      + small interfering RNA (si)CUEDC2 group; whereas, the malondialdehyde content
      was reduced in the DOX + siCUEDC2 group. In addition, flow cytometric analysis
      indicated that mitochondrial membrane potential was maintained following the
      depletion of CUEDC2. Furthermore, CUEDC2 downregulation significantly inhibited
      DOX-induced apoptosis. The expression levels of proapoptotic genes, including B
      cell lymphoma 2 (Bcl-2)-associated X protein, cleaved caspase-3 and cytochrome c
      were inhibited by the depletion of CUEDC2. Conversely, the expression levels of
      the anti-apoptotic gene Bcl-2 were elevated in the CUEDC2 knockdown group.
      Downregulation of CUEDC2 also increased phosphorylation of protein kinase B and
      forkhead box O3a, and decreased the expression of Bcl-2-like protein 11 according
      to western blot analysis. Taken together, the present study demonstrated that
      CUEDC2 downregulation prevented DOX-induced cardiotoxicity in H9c2 cells.
      Therefore, CUEDC2 may be a promising target for the prevention of DOX-induced
      cardiotoxicity.

PMID- 29845246
TI  - Exosome-mediated transfer of lncRNA RP11-838N2.4 promotes erlotinib resistance in
      non-small cell lung cancer.
AB  - Currently, resistance to tyrosine kinase inhibitors, such as erlotinib, has
      become a major obstacle for improving the clinical outcome of patients with
      metastatic and advanced-stage non-small cell lung cancer (NSCLC). While cell
      behavior can be modulated by long non-coding RNAs (lncRNAs), the roles of lncRNAs
      within extracellular vesicles (exosomes) are largely unknown. To this end, in
      this study, the involvement and regulatory functions of potential lncRNAs wrapped
      by exosomes during the development of chemoresistance in human NSCLC were
      investigated. Erlotinib-resistant cell lines were established by grafting HCC827
      and HCC4006 cells into mice and which were treated with erlotinib. After one
      treatment course, xenografted NSCLC cells were isolated and transplanted into
      nude mice again followed by erlotinib treatment. This process was repeated until
      4th generation xenografts were isolated and confirmed to be erlotinib-resistant
      NSCLC cells. lncRNA microarray assays followed by RT-qPCR were then performed
      which identified that lncRNA RP11-838N2.4 was upregulated in erlotinib-resistant
      cells when compared to normal NSCLC cells. Furthermore, bioinformatics analysis
      and chromatin immunoprecipitation revealed that forkhead box protein O1 (FOXO1)
      could bind to the promoter region of lncRNA RP11-838N2.4, resulting in its
      silencing through the recruitment of histone deacetylase. Functional experiments
      demonstrated that the knockdown of lncRNA RP11-838N2.4 potently promoted
      erlotinib-induced cytotoxicity. Furthermore, extracellular lncRNA RP11-838N2.4
      could be incorporated into exosomes and transmitted to sensitive cells, thus
      disseminating erlotinib resistance. Treatment-sensitive cells with exosomes
      containing lncRNA RP11-838N2.4 induced erlotinib resistance, while the knockdown
      of lncRNA RP11-838N2.4 abrogated this effect. In addition, the serum expression
      levels of exosomal lncRNA RP11-838N2.4 were upregulated in patients exhibiting
      resistance to erlotinib treatment. On the whole, exosomal lncRNA RP11-838N2.4 may
      serve as a therapeutic target for patients with NSCLC.

PMID- 29845247
TI  - Long non-coding RNA SENCR alleviates the inhibitory effects of rapamycin on human
      umbilical vein endothelial cells.
AB  - Rapamycin (RPM) is frequently used as the drug coating in drug-eluting stents
      (DESs) as it can inhibit the growth of smooth muscle cells. However, RPM also
      inhibits the proliferation and migration of vascular endothelial cells, and
      impairs reendothelialization in DES implantation. Therefore, the development of a
      strategy to protect vascular endothelial cells after DES implantation is of great
      importance. Long non-coding RNAs (lncRNAs) metastasis-associated lung
      adenocarcinoma transcript 1 (MALAT1) and smooth muscle and endothelial cell
      enriched migration/differentiation-associated lncRNA (SENCR) are able to enhance
      the proliferation, migration and angiogenesis of endothelial cells, which
      suggests that they may have potential as antagonists of the adverse effects of
      RPM in DES. However, the relationship between RPM and lncRNAs in endothelial
      cells during the intervention is not fully understood at present. The current
      study investigated the role and potential mechanism of the lncRNA SENCR on the
      activity of human umbilical vein endothelial cells (HUVECs) after RPM treatment.
      The proliferation, migration, angiogenic capacity and cell cycle progression of
      lncRNA SENCR-overexpressing HUVECs following RPM treatment was examined. The
      proliferation-related proteins of lncRNA SENCR-modified HUVECs were evaluated to
      understand the mechanism of action. LncRNA SENCR significantly alleviated the
      inhibition of proliferation, migration, angiogenesis and cell cycle progression
      of HUVECs caused by RPM by activating extracellular signal-regulated kinase 1/2
      and mammalian target of RPM. The lncRNA SENCR could alleviate the inhibitory
      effects of RPM on HUVECs and may be useful as a new combinative agent to avoid
      the disadvantages of RPM in DES implantation.

PMID- 29845248
TI  - Protective effect of Letinous edodes foot peptides against ethanol-induced liver
      injury in L02 cells.
AB  - The aim of the present study was to evaluate the protective effect and mechanism
      of Letinous edodes foot peptides on ethanol-induced L02 cells. A cell model of
      ethanol-induced damage was established in vitro to study the effects of the
      Letinous edodes foot peptides on human L02 hepatocytes. The expression and
      activity of superoxide dismutase (SOD), malondialdehyde (MDA), aspartate
      aminotransferase (AST), alanine aminotransferase (ALT), alcohol dehydrogenase
      (ADH) and acetaldehyde dehydrogenase (ALDH), following treatment were examined to
      determine the anti-alcoholism and hepatoprotective functions of Letinous edodes
      foot peptides. Taking Letinous edodes foot peptides prior to ethanol exposure was
      more beneficial, which significantly increased SOD activity and the mRNA
      expression of ADH and ALDH suppressed by ethanol. In addition, the intracellular
      MDA content, and AST and ALT activity decreased in ethanol-induced L02 cells
      pretreated with the peptides, when compared with the control. Furthermore,
      Letinous edodes foot peptides inhibited the ethanol-induced activation of the
      proinflammatory cytokines, interleukin-6 and tumor necrosis factor-alpha, and
      promoted the metabolic regulation factors, AMP-activated protein kinase-alpha2
      and peroxisome proliferator-activated receptor-alpha.

PMID- 29845249
TI  - Nicotine inhibits CD24 expression in Lewis lung carcinoma cells by upregulation
      of RAS expression.
AB  - Cluster of ddifferentiation 24 (CD24) is a widely used cancer stem cell (CSC)
      marker in numerous cancer types. However, a number of studies have shown that
      CD24 is a prognostic marker, but not a CSC marker for lung adenocarcinoma. In the
      present study, firstly, bioinformatic analyses were used to identify the CD24
      mRNA levels in the subtypes of lung cancer. Secondly, CD24high and CD24low cells
      were isolated from the side population of Lewis lung carcinoma (LLC) cells using
      flow cytometry. Furthermore, the stemness of CD24high and CD24low cells were
      determined in vivo and in vitro. Lastly, the mechanism(s) of nicotine-inhibited
      CD24 expression in LLC cells were assessed. The main findings of this study are
      that: i) CD24 could be used as a prognostic marker for human lung adenocarcinoma;
      ii) the in vitro and in vivo experiments did not determine a significant
      influence of CD24 on the tumorgenicity of LLC cells; and iii) nicotine inhibited
      CD24 expression in LLC cells by upregulation of RAS. However, the detailed
      mechanism(s) of these results require further analysis.

PMID- 29845250
TI  - Identification of candidate biomarkers and pathways associated with SCLC by
      bioinformatics analysis.
AB  - Small cell lung cancer (SCLC) is one of the highly malignant tumors and a serious
      threat to human health. The aim of the present study was to explore the
      underlying molecular mechanisms of SCLC. mRNA microarray datasets GSE6044 and
      GSE11969 were downloaded from Gene Expression Omnibus database, and the
      differentially expressed genes (DEGs) between normal lung and SCLC samples were
      screened using GEO2R tool. Functional and pathway enrichment analyses were
      performed for common DEGs using the DAVID database, and the protein-protein
      interaction (PPI) network of common DEGs was constructed by the STRING database
      and visualized with Cytoscape software. In addition, the hub genes in the network
      and module analysis of the PPI network were performed using CentiScaPe and plugin
      Molecular Complex Detection. Finally, the mRNA expression levels of hub genes
      were validated in the Oncomine database. A total of 150 common DEGs with absolute
      fold-change >0.5, including 66 significantly downregulated DEGs and 84
      upregulated DEGs were obtained. The Gene Ontology term enrichment analysis
      suggested that common upregulated DEGs were primarily enriched in biological
      processes (BPs), including 'cell cycle', 'cell cycle phase', 'M phase', 'cell
      cycle process' and 'DNA metabolic process'. The common downregulated genes were
      significantly enriched in BPs, including 'response to wounding', 'positive
      regulation of immune system process', 'immune response', 'acute inflammatory
      response' and 'inflammatory response'. Kyoto Encyclopedia of Genes and Genomes
      pathway analysis identified that the common downregulated DEGs were primarily
      enriched in the 'complement and coagulation cascades' signaling pathway; the
      common upregulated DEGs were mainly enriched in 'cell cycle', 'DNA replication',
      'oocyte meiosis' and the 'mismatch repair' signaling pathways. From the PPI
      network, the top 10 hub genes in SCLC were selected, including topoisomerase
      IIalpha, proliferating cell nuclear antigen, replication factor C subunit 4,
      checkpoint kinase 1, thymidylate synthase, minichromosome maintenance protein
      (MCM) 2, cell division cycle (CDC) 20, cyclin dependent kinase inhibitor 3, MCM3
      and CDC6, the mRNA levels of which are upregulated in Oncomine SCLC datasets with
      the exception of MCM2. Furthermore, the genes in the significant module were
      enriched in 'cell cycle', 'DNA replication' and 'oocyte meiosis' signaling
      pathways. Therefore, the present study can shed new light on the understanding of
      molecular mechanisms of SCLC and may provide molecular targets and diagnostic
      biomarkers for the treatment and early diagnosis of SCLC.

PMID- 29845251
TI  - Obovatol inhibits the growth and aggressiveness of tongue squamous cell carcinoma
      through regulation of the EGF-mediated JAK-STAT signaling pathway.
AB  - Migration and invasion are the most important characteristics of human
      malignancies which limit cancer drug therapies in the clinic. Tongue squamous
      cell carcinoma (TSCC) is one of the rarest types of cancer, although it is
      characterized by a higher incidence, rapid growth and greater potential for
      metastasis compared with other oral neoplasms worldwide. Studies have
      demonstrated that the phenolic compound obovatol exhibits anti-tumor effects.
      However, the potential mechanisms underlying obovatol-mediated signaling pathways
      have not been completely elucidated in TSCC. The present study investigated the
      anti-tumor effects and potential molecular mechanisms mediated by obovatol in
      TSCC cells and tissues. The results of the present study demonstrated that
      obovatol exerted cytotoxicity in SCC9 TSCC cells, and inhibited their migration
      and invasion. In addition, obovatol induced apoptosis in SCC9 TSCC cells by
      increasing caspase 9/3 and apoptotic protease enhancing factor 1 expression
      levels. Western blot analysis demonstrated that obovatol inhibited the expression
      of pro-epidermal growth factor (EGF), Janus kinase (JAK), and signal transducer
      and activator of transcription (STAT) in SCC9 TSCC cells. A study of the
      molecular mechanisms demonstrated that depletion of EGF reversed the obovatol
      mediated inhibition of SCC9 TSCC cell growth and aggressiveness. Animal
      experiments indicated that obovatol significantly inhibited TSCC tumor growth and
      increased the number of apoptotic cells in tumor tissues. In conclusion, the
      results of the present study provided scientific evidence that obovatol inhibited
      TSCC cell growth and aggressiveness through the EGF-mediated JAK-STAT signaling
      pathway, suggesting that obovatol may be a potential anti-TSCC agent.

PMID- 29845252
TI  - Leonurine protects cardiac function following acute myocardial infarction through
      anti-apoptosis by the PI3K/AKT/GSK3beta signaling pathway.
AB  - Leonurine is a compound derived from Herba leonuri, which has been reported to
      protect cardiac tissue against ischemic injury via antioxidant and anti-apoptosis
      effects. The present study investigated whether these effects may be applied to
      acute myocardial infarction (MI) and examined the underlying mechanisms of
      leonurine treatment. A rat model of MI was induced by coronary artery ligation.
      Leonurine was administered at 15 mg/kg/day by oral gavage following the onset of
      MI. Rats in the sham group and the saline group were administered with an equal
      volume of saline. Echocardiography, Masson's trichrome staining, and terminal
      deoxynucleotidyl transferase-mediated dUTP nick end labeling assays were
      performed 28 days post MI. The expression of B-cell lymphoma-2 and Bax were
      assessed by western blot analysis and reverse transcription-quantitative
      polymerase chain reaction. Phosphoinositide 3-kinase (PI3K), protein kinase B and
      glycogen synthase kinase-3beta (GSK3beta) protein expression were investigated by
      western blot analysis. Leonurine significantly alleviated collagen deposition and
      MI size, inhibited cell apoptosis and improved myocardial function. This was
      accompanied by significantly increased levels of phosphorylated (p)-PI3K, p-AKT,
      p-GSK3beta and Bcl-2, as well as significantly decreased levels of caspase3,
      cleaved-caspase3 and Bax following MI. The results demonstrated that leonurine
      exerts potent cardio-protective effects in a rat model of MI by inducing anti
      apoptotic effects by activating the PI3K/AKT/GSK3beta signaling pathway.

PMID- 29845253
TI  - VHL loss predicts response to Aurora kinase A inhibitor in renal cell carcinoma
      cells.
AB  - The majority of molecular targets of anticancer agents are limited to a subset of
      patients, and therefore identification of more specific biomarkers that can be
      used to improve clinical outcomes is of increasing interest. The present study
      showed that von Hippel-Lindau tumor suppressor (VHL) tumor-suppressor activity
      may influence the therapeutic response to Aurora kinase A (AURKA) inhibitors in
      human renal cell carcinoma (RCC). VHL protein (pVHL) expression was evaluated by
      immunoblotting in the human RCC cell lines CAKI, ACHN, 786-O, 769-P and A498. The
      anti-tumor activities of alisertib, an AURKA-specific chemical inhibitor, were
      detected by Cell Counting Kit-8 assay in vitro and mouse xenograft model in vivo.
      Additionally, the VHL-mediated anti-tumor activity was assessed in 769-P and CAKI
      cells via the loss or gain of VHL. The results revealed that VHL-deficient 786-O,
      769-P and A498 cells were sensitive to alisertib. By contrast, alisertib
      resistant CAKI and ACHN cells expressed the wild type VHL gene. In addition,
      rescue or knockdown of VHL was observed to increase or decrease alisertib anti
      proliferation activity, respectively, in RCC cells. The inverse correlation
      between the VHL gene expression profile and alisertib sensitivity was further
      confirmed in human cancer xenografts models. Taken together, these results
      suggested that VHL loss could potentially serve as a biomarker for predicting the
      efficacy of AURKA inhibitors.

PMID- 29845254
TI  - High mobility group box 1 promotes the epithelial-to-mesenchymal transition in
      prostate cancer PC3 cells via the RAGE/NF-kappaB signaling pathway.
AB  - High mobility group box 1 (HMGB1), a critical damage-associated molecular pattern
      molecule, has been implicated in several inflammatory diseases and cancer types.
      The overexpression of HMGB1 protein occurs in prostate cancer, and is closely
      associated with the proliferation and aggressiveness of tumor cells. However, the
      underlying mechanisms of HMGB1-induced tumor metastasis in prostate cancer remain
      unclear. In the present study, it was demonstrated that the expression of HMGB1
      was high in prostate cancer samples, particularly in the metastatic tissues.
      Furthermore, recombinant HMGB1 (rHMGB1) enhanced the invasive and metastatic
      capabilities of the prostate cancer cells. Molecular phenotype alterations of
      epithelial-to-mesenchymal transition (EMT) and elevated expression levels of
      matrix metalloproteinase (MMP)-1, -3 and -10 were observed. In addition, advanced
      glycosylation end-product specific receptor (RAGE) and its downstream molecule
      nuclear factor (NF)-kappaB pathway were activated during rHMGB1-induced
      metastasis. Silencing RAGE or NF-kappaB reversed the upregulation of MMP and EMT
      marker expression levels, thus reducing the migration and invasiveness of tumor
      cells. Taken together, these results suggest that highly expressed HMGB1 drives
      EMT and the overexpression of MMP-1, -3, -10 via the RAGE/NF-kappaB signaling
      pathways, which facilitates the metastasis of prostate cancer and may be a
      potential therapeutic target for metastatic prostate cancer.

PMID- 29845255
TI  - miR-1 inhibits the progression of colon cancer by regulating the expression of
      vascular endothelial growth factor.
AB  - MicroRNA (miR)-1 is associated with various human malignancies through repressing
      tumor growth, migration and angiogenesis. Recently, high-throughput
      transcriptional profiling confirmed that miR-1 is markedly downregulated in
      metastatic colorectal cancer; however, its biological functions and the specific
      underlying mechanisms in colorectal cancer (CRC) require further investigation.
      In this study, the expression of miR-1 in 111 CRC and paired normal tissue
      samples was measured using quantitative polymerase chain reaction analysis, and
      the association between miR-1 expression and clinical characteristics was
      evaluated. miR-1 was found to be significantly downregulated in CRC tissues
      compared with paired normal tissues, and in CRC cell lines compared with non
      cancer cells (P<0.001), and was negatively associated with tumor size (P=0.001),
      differentiation (P=0.011), lymph node metastasis (P=0.001) and TNM stage
      (P=0.001). Further experiments revealed that miR-1 inhibited the migration and
      invasion of HCT116 and ClonA1 cells, and inhibited cell proliferation by
      affecting the cell cycle. Vascular endothelial growth factor (VEGF) was found to
      be a potential target of miR-1 by biological prediction, and further
      investigation confirmed that miR-1 significantly inhibited the expression and
      paracrine function of VEGF. In CRC tissues, the expression of VEGF was negatively
      correlated with miR-1. The low expression of miR-1 in CRC may be one of the
      reasons for the abnormally high expression of VEGF; the upregulation of miR-1
      expression may inhibit cancer progression by downregulating VEGF. These findings
      indicate that treatment with miR-1 may be a novel method of tumor suppression,
      and provide a theoretical and experimental basis for the further targeted
      treatment of CRC through the regulation of miR-1 and VEGF expression.

PMID- 29845256
TI  - Cold PSM, but not TRAIL, triggers autophagic cell death: A therapeutic advantage
      of PSM over TRAIL.
AB  - Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and cold plasma
      stimulated medium (PSM) are promising novel anticancer tools due to their strong
      anticancer activities and high tumor-selectivity. The present study demonstrated
      that PSM and TRAIL may trigger autophagy in human malignant melanoma and
      osteosarcoma cells. Live-cell imaging revealed that even under nutritional and
      stress-free conditions, these cells possessed a substantial level of
      autophagosomes, which were localized in the cytoplasm separately from tubular
      mitochondria. In response to cytotoxic levels of PSM, the mitochondria became
      highly fragmented, and aggregated and colocalized with the autophagosomes. The
      cytotoxic effects of PSM were suppressed in response to various pharmacological
      autophagy inhibitors, including 3-methyladenine (3-MA) and bafilomycin A1, thus
      indicating the induction of autophagic cell death (ACD). Lethal levels of PSM
      also resulted in non-apoptotic, non-autophagic cell death in a reactive oxygen
      species-dependent manner under certain circumstances. Furthermore, TRAIL
      exhibited only a modest cytotoxicity toward these tumor cells, and did not induce
      ACD and mitochondrial aberration. The combined use of TRAIL and subtoxic
      concentrations of 3-MA resulted in decreased basal autophagy, increased
      mitochondrial aberration, colocalization with autophagosomes and apoptosis. These
      results indicated that PSM may induce ACD, whereas TRAIL may trigger
      cytoprotective autophagy that compromises apoptosis. To the best of our
      knowledge, the present study is the first to demonstrate that PSM can induce ACD
      in human cancer cells. These findings provide a rationale for the advantage of
      PSM over TRAIL in the destruction of apoptosis-resistant melanoma and
      osteosarcoma cells.

PMID- 29845257
TI  - Montelukast, a cysteinyl leukotriene receptor antagonist, inhibits the growth of
      chronic myeloid leukemia cells through apoptosis.
AB  - The clinical outcome for patients with chronic myeloid leukemia (CML) has
      improved significantly with the introduction of tyrosine kinase inhibitors
      (TKIs). However, their curative potential appears limited, probably as a
      consequence of TKI-resistant leukemic stem cells (LSCs) that persist as a result
      of aberrant pathways independent of the well-established oncoprotein Bcr-Abl. One
      such pathway involves signaling through leukotrienes (LTs), bioactive compounds
      that have been suggested to play a role in several other malignancies. Cysteinyl
      LT1 receptor (CysLT1R) has been reported to be overexpressed in a number of solid
      cancers, and blocking of this receptor with the antagonist montelukast (treatment
      approved for bronchial asthma) has resulted in the killing of cancer cells. We
      recently demonstrated that montelukast, alone or in combination with imatinib,
      can effectively reduce the growth of CML cells, while normal bone marrow cells
      were left unaffected. Herein, we further investigated the importance of CysLT1R
      for the survival of CML cells and the mechanisms by which montelukast induces
      cell death. Knockdown of the CysLT1R of K562 cells with siRNA reduced their
      growth by 25%. Montelukast had no effect on these cells, while it killed more
      than 50% of CysLT1R-expressing cells. Growth inhibition exerted by imatinib was
      unaffected by CysLT1R status. Montelukast-induced killing of K562/JURL-MK1 CML
      cells was paralleled by Bax overexpression, cytochrome c release, PARP-1
      cleavage, and caspase-3 activation, an event further increased in a setting where
      montelukast was added to imatinib. Wnt/beta-catenin signaling was activated by
      CysLT1R and we observed that montelukast could induce proteins in this pathway, a
      finding of relevance for LSC survival. Thus, montelukast, employed at in vivo
      like concentrations, induces the killing of CML cells through apoptotic pathways
      and may provide an additional, novel therapeutic possibility in CML.

PMID- 29845258
TI  - Napsin A is negatively associated with EMT-mediated EGFR-TKI resistance in lung
      cancer cells.
AB  - Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have been
      used as a standard therapy for patients with lung cancer with EGFR-activating
      mutations. Epithelial-mesenchymal transition (EMT) has been reported to be
      associated with the development of EGFR-TKI resistance, which limits the clinical
      efficacy of EGFR-TKI. Therefore, investigating the resistance-associated
      mechanism is required in order to elucidate an effective therapeutic approach to
      enhance the sensitivity of lung cancer to EGFR-TKI. In the present study, EGFR
      TKI erlotinib-sensitive H358, H322 and H441 lung cancer cells, erlotinib
      moderately sensitive A549 cells, and erlotinib-insensitive HCC827 cells with EGFR
      mutation (exon 19 deletion) were used to detect the mRNA and protein expression
      of the EMT-associated proteins E-cadherin and vimentin, and napsin A, by reverse
      transcription-quantitative polymerase chain reaction analysis and western
      blotting. It was observed that the E-cadherin expression level in erlotinib
      sensitive cells was increased compared with the moderately sensitive A549 cells
      and HCC827 cells; however, vimentin exhibited opposite expression, suggesting a
      correlation between EMT and erlotinib sensitivity in lung cancer cells. The
      napsin A expression level was observed to be positively associated with erlotinib
      sensitivity. In addition, napsin A highly-expressingH322 cells were used and
      napsin A-silenced cells were constructed using small interfering RNA (siRNA)
      technology, and were induced by transforming growth factor (TGF)-betal. It was
      observed that TGF-betal partially induced the alterations in E-cadherin and
      vimentin expression and the occurrence of EMT in napsin A highly-expressing
      cells, while TGF-betal significantly induced EMT via downregulation of E-cadherin
      and upregulation of vimentin in napsin A-silenced cells; cell proliferation and
      apoptosis assays demonstrated that TGF-betal induced marked resistance to
      erlotinib in napsin A-silenced cells compared with napsin A-expression cells.
      These data indicated that napsin A expression may inhibit TGF-betal-induced EMT
      and was negatively associated with EMT-mediated erlotinib resistance, suggesting
      that napsin A expression may improve the sensitivity of lung cancer cells to EGFR
      TKI through the inhibition of EMT.

PMID- 29845259
TI  - shRNA-induced knockdown of the SPERT gene inhibits proliferation and promotes
      apoptosis of human colorectal cancer RKO cells.
AB  - Colorectal cancer is the third most common type of cancer and the fourth leading
      cause of cancer-related deaths worldwide. Although several genes have been
      identified to contribute to the pathogenesis of colorectal cancer, there are
      still many genes with unidentified functions in colorectal cancer. This study
      aimed to investigate the effect of shRNA-induced knockdown of the SPERT gene on
      the proliferation and apoptosis of human colorectal cancer RKO cells. SPERT was
      screened based on the TCGA dataset, and SPERT expression, cell growth,
      proliferation and apoptosis were detected in shSPERT- and shCtrl-transfected RKO
      cells. In addition, the SPERT-related biological pathways were detected using a
      PathScan(r) Signaling Antibody Array Kit. We detected lower SPERT expression in
      shSPERT-transfected RKO cells than in shCtrl-transfected cells at both the
      translational and transcriptional levels (P<0.05), and an MTT assay revealed a
      clear-cut decrease in the proliferation of shSPERT-transfected RKO cells relative
      to shCtrl-transfected RKO cells (P<0.01). A Caspase-Glo(r) 3/7 assay detected an
      increase in the caspase-3/7 activity and the number of apoptotic cells in the
      shSPERT-transfected RKO cells than in the shCtrl-transfected cells (P<0.01), and
      flow cytometry detected a higher apoptotic rate in the shSPERT-transfected RKO
      cells than in the shCtrl-transfected cells (20.65+/-0.26 vs. 5.93+/-0.06%,
      respectively, P<0.01). Elevated levels of phosphorylated p44/42 MAPK (ERK1/2),
      Akt, Bad, HSP27, p38 MARK and Chk2, and elevated PARP and caspase-3 expression
      levels were detected in shSPERT-transfected RKO cells compared with the shCtrl
      transfected cells (P<0.05). The results of the current study demonstrated that
      knockdown of SPERT suppresses colorectal cancer cell growth and promotes
      apoptosis. SPERT may serve as an oncogene and may be a potential target for the
      treatment of colorectal cancer.

PMID- 29845260
TI  - Two rare missense mutations in the fibrillin-1 gene associated with atypical
      cardiovascular manifestations in a Chinese patient affected by Marfan syndrome.
AB  - The present report aimed to evaluate the results of screen mutations of the
      fibrillin (FBN) 1 gene and analyze the symptoms in one Chinese patient clinically
      diagnosed with Marfan syndrome (MFS). Clinical data were collected and FBN1 gene
      sequencing was performed. Genomic DNA was extracted from the blood sample of the
      patient. All 65 exons were screened using a polymerase chain reaction assay. The
      diagnosis of MFS was confirmed via identification of symptoms presenting in the
      skeletal system (arachnodactyly, walker wrist and thumb signs) and the ocular
      system (ectopia lentis), in addition to a positive family history. The patient's
      cardiovascular manifestations (dilatation of the four cardiac chambers, severe
      mitral valve regurgitation and a large saccular aneurysm of the non-coronary
      sinus of Valsalva) were atypical to those that most frequently occur in cases of
      MFS. Following gene sequencing, two novel heterozygous mutations of the FBN-1
      gene were identified: c.3442C>G in exon 27, proline replaced with alanine (p.
      Pro1148Ala) and c.6388G>A in exon 52, glutamic acid replaced with lysine (p.
      Glu2130Lys). The clinical symptoms and family history were important in the
      diagnosis of MFS, however the atypical signs that presented in the cardiovascular
      system may be associated with the disease, and may be noted for further cases in
      the future. Gene sequencing further verified the correct diagnosis of MFS.

PMID- 29845261
TI  - Candesartan targeting of angiotensin II type 1 receptor demonstrates benefits for
      hypertension in pregnancy via the NF-kappaB signaling pathway.
AB  - Hypertensive disorders may be a complication of pregnancy and are characterized
      by the high blood pressure. Evidence suggests that alterations in the renin
      angiotensin-aldosterone system and the sympathetic nervous system are associated
      with gestational hypertension. Angiotensin II type 1 receptor (Ang-IITR) is a
      potential target in the progression of gestational hypertension. Candesartan is
      selective Ang-IITR antagonist that may act against vasoconstriction and reduces
      peripheral vascular resistance. The aim of the present study was to evaluate the
      efficacy of Candesartan and the underlying molecular mechanism of the nuclear
      factor-kappaB (NF-kappaB) signaling pathway in the progression of gestational
      hypertension in a mouse model. Expression and activity of Ang-IITR was evaluated
      in a mouse model of gestational hypertension prior to and post-treatment of
      Candesartan both in vitro and in vivo. It was determined whether Candesartan
      treatment reduces higher blood pressure activated the renal renin-angiotensin
      system and a prognostic marker, soluble endoglin, and its associated gene in mice
      with gestational hypertension. Angiotensin-converting enzyme plasma levels and
      activity were also evaluated in the present study. Cytoplasmic and nuclear
      immunostaining of NF-kappaB and associated proteins transforming growth factor
      beta (TGF-beta) and endoglin was enhanced in vascular endothelial cells and mice
      with gestational hypertension. Soluble fms-like tyrosine kinase 1 (sFlt-1),
      insulin resistance homeostasis model assessment score and associated
      cardiovascular risk factors also were measured. Results demonstrated that
      angiotensin and Ang-IITR expression levels were upregulated in mice with
      gestational hypertension and were downregulated by Candesartan treatment. Renal
      renin-angiotensin and soluble endoglin were also improved in mice in the
      Candesartan-treated group. In addition, Candesartan treatment enhanced NF-kappaB
      activity, as well as TGF-beta and vascular endothelial growth factor expression
      which led to improved levels of sFlt-1, insulin resistance homeostasis and
      associated cardiovascular risk factors. Gestational hypertension was markedly
      improved by treatment of Candesartan compared with the control. In conclusion,
      the findings of the present study suggested that the NF-kappaB signaling pathway
      may be involved in with Candesartan-mediated Ang-IITR for the treatment of
      gestational hypertension.

PMID- 29845263
TI  - Novel triple-positive markers identified in human non-small cell lung cancer cell
      line with chemotherapy-resistant and putative cancer stem cell characteristics.
AB  - Through the specific identification and direct targeting of cancer stem cells
      (CSCs), it is believed that a better treatment efficacy of cancer may be
      achieved. Hence, the present study aimed to identify a CSC subpopulation from
      adenocarcinoma cells (A549) as a model of non-small cell lung cancer (NSCLC).
      Iotanitially, we sorted two subpopulations known as the triple-positive
      (EpCAM+/CD166+/CD44+) and triple-negative (EpCAM-/CD166-/CD44-) subpopulation
      using fluorescence-activated cell sorting (FACS). Sorted cells were subsequently
      evaluated for proliferation and chemotherapy-resistance using a viability assay
      and were further characterized for their clonal heterogeneity, self-renewal
      characteristics, cellular migration, alkaline dehydrogenase (ALDH) activity and
      the expression of stemness-related genes. According to our findings the triple
      positive subpopulation revealed significantly higher (P<0.01) proliferation
      activity, exhibited better clonogenicity, was mostly comprised of holoclones and
      had markedly bigger (P<0.001) spheroid formation indicating a better self-renewal
      capacity. A relatively higher resistance to both 5-fluouracil and cisplatin with
      80% expression of ALDH was observed in the triple-positive subpopulation,
      compared to only 67% detected in the triple-negative subpopulation indicated that
      high ALDH activity contributed to greater chemotherapy-resistance
      characteristics. Higher percentage of migrated cells was observed in the triple
      positive subpopulation with 56% cellular migration being detected, compared to
      only 19% in the triple-negative subpopulation on day 2. This was similarly
      observed on day 3 in the triple-positive subpopulation with 36% higher cellular
      migration compared to the triple-negative subpopulation. Consistently, elevated
      levels of the stem cell genes such as REX1 and SSEA4 were also found in the
      triple-positive subpopulation indicating that the subpopulation displayed a
      strong characteristic of pluripotency. In conclusion, our study revealed that the
      triple-positive subpopulation demonstrated similar characteristics to CSCs
      compared to the triple-negative subpopulation. It also confirmed the feasibility
      of using the triple-positive (EpCAM+/CD166+/CD44+) marker as a novel candidate
      marker that may lead to the development of novel therapies targeting CSCs of
      NSCLC.

PMID- 29845264
TI  - Novel CTCF mutations in Chinese patients with ovarian endometriosis.
AB  - Endometriosis is a common gynecological disease characterized by the outgrowth of
      the endometrium, however, the detailed molecular etiology remains largely
      uncharacterized. Recent studies have implicated that endometriosis is potentially
      a precancerous lesion, and that CCCTC-binding factor (CTCF) mutations may be
      involved in the pathogenesis of this disorder. However, the detailed CTCF
      mutation spectrum in Chinese patients with ovarian endometriosis remains largely
      unknown. In the present study, a cohort of 92 patients with ovarian endometriosis
      were analyzed for the presence of CTCF mutations by sequencing the entire coding
      regions. In addition, 67 healthy eutopic endometrial tissues and 46 healthy
      ovarian tissues from control samples (without endometriosis) were also analyzed.
      In total, two CTCF missense mutations, p.K206E (c.616A>G) and p.H373L
      (c.1118A>T), were identified in 2/92 (2.2%) endometriotic lesions. The patient
      with the p.K206E mutation was 26 years old and diagnosed with primary
      infertility, whereas the patient with the p.H373L mutation was 37 years old and
      concurrently diagnosed with uterine leiomyoma. The p.H373L mutation was
      previously identified in endometrial cancer samples with low frequency, while the
      p.K206E mutation was novel. In addition, no CTCF mutations were detected in the
      67 healthy eutopic endometrial and 46 healthy ovarian tissue samples. In silico
      prediction and evolutionary conservation analysis suggested that these CTCF
      mutations may be pathogenic. In summary, the present study identified 2 potential
      pathogenic CTCF mutations in endometriotic lesions from 2/92 patients with
      ovarian endometriosis. These results, together with a prior exome-sequencing
      based study, suggest that CTCF mutations may be involved in the development of
      ovarian endometriosis.

PMID- 29845262
TI  - Computational modeling and biomarker studies of pharmacological treatment of
      Alzheimer's disease (Review).
AB  - Alzheimer's disease (AD) is a complex and multifactorial disease. In order to
      understand the genetic influence in the progression of AD, and to identify novel
      pharmaceutical agents and their associated targets, the present study discusses
      computational modeling and biomarker evaluation approaches. Based on mechanistic
      signaling pathway approaches, various computational models, including biochemical
      and morphological models, are discussed to explore the strategies that may be
      used to target AD treatment. Different biomarkers are interpreted on the basis of
      morphological and functional features of amyloid beta plaques and unstable
      microtubule-associated tau protein, which is involved in neurodegeneration.
      Furthermore, imaging and cerebrospinal fluids are also considered to be key
      methods in the identification of novel markers for AD. In conclusion, the present
      study reviews various biochemical and morphological computational models and
      biomarkers to interpret novel targets and agonists for the treatment of AD. This
      review also highlights several therapeutic targets and their associated signaling
      pathways in AD, which may have potential to be used in the development of novel
      pharmacological agents for the treatment of patients with AD. Computational
      modeling approaches may aid the quest for the development of AD treatments with
      enhanced therapeutic efficacy and reduced toxicity.

PMID- 29845265
TI  - PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines.
AB  - Osteosarcoma is the most common malignant bone carcinoma that primarily occurs
      between childhood to adolescence. It was suggested by recent research that the
      Brain type glycogen phosphorylase (PYGB) gene may serve an important role in
      various types of cancer. In the present study, the PYGB gene was knocked down in
      order to evaluate the cell viability, invasion and migration of the human
      osteosarcoma cell lines MG63 and HOS. The expression levels of PYGB in
      osteosarcoma and bone cyst tissue samples, as well as in the osteosarcoma cell
      lines were identified using reverse transcription-quantitative polymerase chain
      reaction and western blot assay. Subsequently, a Cell Counting kit 8 assay was
      employed to evaluate cell proliferation. Cell apoptosis rate and cell cycle
      distribution were measured by flow cytometry. In addition, cell invasion and
      migration were evaluated through a Transwell assay. The expression levels of the
      cell apoptosis and tumor metastasis associated proteins B-cell lymphoma 2 (Bcl
      2), Bcl-2-associated X protein, E-cadherin, Twist, matrix metalloproteinase (MMP)
      9 and MMP2 were measured via western blotting. PYGB exhibited a higher expression
      level in the osteosarcoma tissue samples, particularly in the human osteosarcoma
      cell lines MG63 and HOS. Knockdown of PYGB resulted in a decline in cell
      proliferation, invasion and migration, which was coupled with induced cell
      apoptosis and cell cycle arrest in MG63 and HOS cells. Furthermore, alterations
      in the expression of apoptosis and metastasis associated proteins indicated that
      small interfering (si)PYGB may have regulated cell viability by targeting the
      Bcl/Caspase and cyclin dependent kinase (CDK)-1 signaling pathway. In conclusion,
      PYGB siRNA exerted an inhibitory effect on the cell viability of the human
      osteosarcoma cells MG63 and HOS by blocking the Caspase/Bcl and CDK1 signaling
      pathway, highlighting novel potential therapeutic methods for treating
      osteosarcoma.

PMID- 29845266
TI  - TLR4/PKCalpha/occludin signaling pathway may be related to blood-brain barrier
      damage.
AB  - Abnormal blood-brain barrier (BBB) is a common pathological feature in brain
      damage. In the present study, a brain microvascular endothelial cell (BMEC) model
      was established to determine the role of the toll-like receptor 4 (TLR4)/protein
      kinase Calpha (PKCalpha)/occludin signaling pathway in BBB dysfunction. Three
      small interfering (si)RNAs directed against PKCalpha were designed to investigate
      the molecular mechanisms of PKCalpha underlying BBB damage. BMECs were divided
      into 4 groups: Control group, TAK-242 (a TLR4 inhibitor) group, PKCalpha-siRNA
      group and TAK-242+PKCalpha-siRNA group. The results indicated that siRNA-3 was
      the most effective at silencing PKCalpha gene expression. Reverse transcription
      quantitative polymerase chain reaction (RT-qPCR) analysis indicated no
      significant difference of TLR4 mRNA expression levels between three different
      treated groups and the Control group. However, PKCalpha mRNA expression in the
      PKCalpha-siRNA and TAK-242+PKCalpha-siRNA groups were significantly decreased
      compared with that in Control and TAK-242 groups. In addition, occludin mRNA
      expression in PKCalpha-siRNA and TAK-242+PKCalpha-siRNA groups were significantly
      higher compared with the Control group. Meanwhile, occluding expressions in three
      treated groups were also significantly higher compared with the Control group.
      Furthermore, TAK-242 treatment, PKCalpha-siRNA treatment, and TAK-242+PKCalpha
      siRNA treatment could promote occludin junctional labeling compared with the
      Control group. The permeability of PKCalpha-siRNA and TAK-242+PKCalpha-siRNA
      groups was significantly promoted compared with the control group. The
      TLR4/PKCalpha/occludin signaling pathway was closely related to BBB damage. The
      present study will lead to an improved molecular understanding of BBB damage in
      the future.

PMID- 29845267
TI  - MicroRNA-92a-3p inhibits the cell proliferation, migration and invasion of Wilms
      tumor by targeting NOTCH1.
AB  - Dysregulation of miR-92a-3p has been shown to contribute to many tumorigenic
      processes, and is correlated with tumor progression and prognosis. However, the
      association between miR-92a-3p and the clinicopathological features of Wilms
      tumorand its regulatory mechanism remain unknown. In the present study, we
      demonstrated that miR-92a-3p was downregulated in Wilms tumor tissues and was
      significantly correlated with the lung metastasis of patients with Wilms tumor.
      Furthermore, miR-92a-3p mimics suppressed Wilms tumor cell proliferation,
      migration and invasion by in vitro assays. In addition, miR-92a-3p knockdown
      promoted tumor progression. Moreover, miR-92a-3p was shown to target directly the
      3'-UTR of NOTCH1 mRNA by Dual-Luciferase reporter assays in Wilm's tumor cells.
      miR-92a-3p mimics decreased the expression of mRNA and protein of NOTCH1. miR-92a
      3p inhibitor enhanced NOTCH1 expression by using western blotting and qPCR. In
      Wilms tumor tissues, NOTCH1 was highly expressed when compared with that in
      adjacent non-tumor tissues. NOTCH1 expression was found to be negatively
      correlated with miR-92a-3p in tumor tissues. Knockdown of NOTCH1 expression
      reversed the promotive effect of miR-92a-3p inhibitor on the cell proliferation,
      migration and invasion in Wilms tumor. In conclusion, miR-92a-3p blocks the
      progression of Wilms tumor by targeting NOTCH1.

PMID- 29845268
TI  - Construction and analysis of a ceRNA-ceRNA network reveals two potential
      prognostic modules regulated by hsa-miR-335-5p in osteosarcoma.
AB  - Osteosarcoma is an aggressive cancer of the skeletal system, which is associated
      with a poor prognosis due to the high recurrence rate. Although previous studies
      have revealed that competitive endogenous RNAs (ceRNAs) are involved in various
      biological processes in the physiology and development of osteosarcoma, the roles
      of ceRNAs in osteosarcoma recurrence remain largely unexplored. The present study
      constructed a ceRNA-ceRNA network for osteosarcoma by systematically integrating
      matched expression profiles for microRNAs (miRNAs/miRs) and mRNAs, and identified
      two ceRNA-mediated modules that were associated with recurrence in patients with
      osteosarcoma. A multivariate Cox regression analysis demonstrated that the
      recurrence-free prognosis associated with the expression of the two modules was
      independent of other clinical factors. In addition, hsa-miR-335-3p was identified
      as an upstream regulating factor for both modules. In conclusion, the results of
      the present study suggested that ceRNAs may act as potential therapeutic
      biomarkers for predicting the recurrence of osteosarcoma, and may help to
      identify patients with osteosarcoma at a high risk of recurrence, who may benefit
      from adjuvant therapy.

PMID- 29845269
TI  - Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury
      (Review).
AB  - Autophagy is a maintenance process for recycling long-lived proteins and
      cytoplasmic organelles. The level of this process is enhanced during
      ischemia/reperfusion (I/R) injury. Autophagy can trigger survival signaling in
      myocardial ischemia, whereas defective autophagy during reperfusion is
      detrimental. Autophagy can be regulated through multiple signaling pathways in
      I/R, including Beclin-1/class III phosphatidylinositol-3 kinase (PI-3K),
      adenosine monophosphate activated protein kinase/mammalian target of rapamycin
      (mTOR), and PI-3K/protein kinase B/mTOR pathways, which consequently lead to
      different functions. Thus, autophagy has both protective and detrimental
      functions, which are determined by different signaling pathways and conditions.
      Targeting the activation of autophagy can be a promising new therapeutic strategy
      for treating cardiovascular disease.

PMID- 29845270
TI  - Luteolin reduces cancer-induced skeletal and cardiac muscle atrophy in a Lewis
      lung cancer mouse model.
AB  - Luteolin was recently demonstrated to suppress tumor growth by interfering with
      nuclear factor (NF)-kappaB activation. As the NF-kappaB pathway plays a critical
      role in muscular atrophy associated with cancer cachexia, we aimed to investigate
      the potential of luteolin to alleviate cancer-associated cachexia in a Lewis lung
      cancer mouse model. C57BL/6 mice were divided into three groups: A control group,
      a model group and a luteolin group. Mice in the model and luteolin groups
      received a subcutaneous injection of Lewis lung cancer cells, while the control
      group received PBS. Subsequently, the tumor mass, serum, gastrocnemius muscle and
      heart were collected on day 21. The serum, gastrocnemius muscle and heart were
      weighed and prepared for use in enzyme-linked immunosorbent assay (ELISA),
      western blotting (WB) and quantitative reverse transcription polymerase chain
      reaction (qRT-PCR) analyses. The results revealed that the tumor-free body mass
      was significantly reduced in tumor-bearing mice compared with that of mice in the
      other groups. The gastrocnemius muscle mass and heart mass were greater in the
      luteolin treatment group than in the control group. Tumor necrosis factor (TNF)
      alpha and interleukin (IL)-6 levels were lower in the luteolin treatment group
      than in the model group. In addition, according to the results of the WB and qRT
      PCR analyses, the expression of the E3 ubiquitin ligase muscle RING finger
      containing protein 1 (MuRF1) was downregulated in skeletal muscle and cardiac
      muscle, whereas atrogin-1 was downregulated only in skeletal muscle in the
      luteolin treatment group vs. the model group. Furthermore, IkappaB kinase beta
      (IKKbeta) and phospho-p65 were significantly downregulated in skeletal muscle and
      cardiac tissue, whereas the expression of p-p38 was downregulated only in
      skeletal muscle in the luteolin treatment group when compared with their
      expression levels in the model group, as determined by the WB analysis. In
      conclusion, from the current results, we conclude that luteolin is able to reduce
      inflammatory burden, downregulate the expression of genes associated with muscle
      protein breakdown, and protect skeletal and heart muscle from cancer-induced
      wasting and loss in vivo. Therefore, luteolin has the potential to be developed
      into a novel anti-cachetic agent.

PMID- 29845271
TI  - Cryptotanshinone inhibits IgE-mediated degranulation through inhibition of spleen
      tyrosine kinase and tyrosine-protein kinase phosphorylation in mast cells.
AB  - Atopic dermatitis (AD) is a type of chronic skin inflammation and one of the most
      common relapsing allergic diseases, which presents with a severe rash and itchy
      skin lesions. The pathogenesis of AD is primarily associated with hyper-activated
      mast cells, which makes them an effective treatment target. After cross-linking
      the antigen/immunoglobulin (Ig) E complex binds to its high affinity receptor
      FcepsilonRl on the surface of mast cells. The cells subsequently secrete
      excessive pro-inflammatory mediators, including histamine and cytokines, which
      lead to pruritus and immune cell infiltration in the skin lesions. The present
      study screened natural compounds that have an inhibitory effect on IgE/antigen
      mediated secretory activity. It was revealed that cryptotanshinone (CRT), a
      natural compound extracted from Salvia miltiorrhiza Bunge, had inhibitory effects
      on the IgE/antigen complex. The underlying mechanism by which CRT exerted an anti
      allergy/inflammatory function was investigated using rat basophilic leukaemia
      (RBL) cells for degranulation assays and a 1-chloro-2,4-dinitrobenzene (DNCB)
      induced AD Balb/c mouse model for in vivo study. CRT effectively mitigated the
      secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha
      and interleukin 1beta, as well as immune cell infiltration into skin lesions in a
      mouse model of AD-like skin disease induced by dinitrochlorobenzene. The
      inhibitory effect of CRT on IgE-mediated mast cell degranulation was mediated by
      the inhibition of tyrosine kinase-dependent degranulation signalling pathways
      involving spleen tyrosine kinase and Lyn. The present study revealed CRT as an
      inhibitor of mast cell degranulation. Therefore, CRT may be considered for
      development as a therapeutic drug to treat IgE-mediated skin diseases.

PMID- 29845272
TI  - Therapeutic effect of the natural compounds baicalein and baicalin on autoimmune
      diseases.
AB  - A series of natural compounds have been implicated to be useful in regulating the
      pathogenesis of various autoimmune diseases. The present study demonstrated that
      the Scutellariae radix compounds baicalein and baicalin may serve as drugs for
      the treatment of autoimmune diseases, including rheumatoid arthritis and
      inflammatory bowel disease. Following the administration of baicalein and
      baicalin in vivo, T cell-mediated autoimmune diseases in the mouse model were
      profoundly ameliorated: In the collagen-induced arthritis model (CIA), the
      severity of the disease was reduced by baicalein and, consistently, baicalein was
      demonstrated to suppress T cell proliferation in CIA mice. In the dextran sodium
      sulfate (DSS)-induced colitis model, the disease was attenuated by baicalin, and
      baicalin promoted colon epithelial cell (CEC) proliferation in vitro. The present
      study further revealed that the mRNA expression of signal transducer and
      activator of transcription (STAT)3 and STAT4 in the tyrosine-protein kinase JAK
      STAT signaling pathway in T cells was downregulated by baicalein, contributing to
      its regulation of T cell proliferation. However, in the DSS model, the STAT4
      transcription in CECs, which are the target cells of activated T cells in the
      gut, was downregulated by baicalin, suggesting that baicalein and baicalin
      mediated similar STAT expression in different cell types in autoimmune diseases.
      In conclusion, the similarly structured compounds baicalein and baicalin
      selectively exhibited therapeutic effects on autoimmune diseases by regulating
      cell proliferation and STAT gene expression, albeit in different cell types.

PMID- 29845273
TI  - Spinal glucocorticoid receptor-regulated chronic morphine tolerance may be
      through extracellular signal-regulated kinase 1/2.
AB  - Opioid use has been limited in the treatment of chronic pain due to their side
      effects, including analgesic tolerance. Previous studies demonstrated that
      glucocorticoid receptors (GRs) may be involved in the development of chronic
      morphine tolerance; however, the mechanism remains unknown. It was hypothesized
      that the expression of spinal phosphorylated mitogen-activated protein kinase
      [MAPK; phosphorylated extracellular signal-regulated kinase (ERK)] is regulated
      through the spinal GRs, following chronic treatment with morphine. In the first
      experiment, the experimental rats were randomly divided into four groups:
      Control, morphine, morphine+GR antagonist mifepristone (RU38486) and morphine+GR
      agonist dexamethasone (Dex). Each group was treated with continuous intrathecal
      (IT) injection of the drugs for 6 days. The expression of GRs and MAPK 3/1 (p-ERK
      1/2) in the spinal dorsal horn was detected by western blot analysis and
      immunofluorescence staining. In the second experiment, the MAPK inhibitor PD98059
      was added and the rats were randomly divided into four groups: Control, morphine,
      PD98059+morphine and PD98059+morphine+Dex. The continuous IT injection lasted for
      7 days in each group. For all experiments, the tail flick test was conducted 30
      min following administration every day to assess the thermal hyperalgesia of the
      rats. The experimental results demonstrated that there was a co-existence of GRs
      and p-ERK 1/2 in the spinal cord dorsal horn by double immunofluorescence
      staining. The GR antagonist RU38486 attenuated the morphine analgesia tolerance
      by inhibiting the expression of GR and increasing the expression of p-ERK. The
      MAPK inhibitor PD98059 increased the effect of morphine tolerance and prolonged
      the duration of morphine tolerance. The present results suggest that spinal GRs
      may serve an important role in the development of morphine tolerance through the
      ERK signaling pathway.

PMID- 29845274
TI  - Increased B cell activating factor is associated with B cell class switching in
      patients with tuberculous pleural effusion.
AB  - B cell activating factor (BAFF), a member of the tumor necrosis factor family, is
      a key cytokine for B cell survival, a function that is essential for B cell
      maturation and memory. The expression levels of BAFF and its potential
      contribution to B cell maturation remain elusive in patients with tuberculous
      pleural effusion (TPE). The present study enrolled 40 healthy controls (HC) and
      45 TPE patients, and investigated the levels of BAFF in the plasma and pleural
      effusion. Concomitantly, B cell subsets including naive B cell (CD19+IgD+CD27-),
      unswitched B cell (CD19+IgD+CD27+), switched B cell (CD19+IgD-CD27+), total
      memory B cell (CD19+CD27+), plasma B cell (CD19+IgD-CD38+CD27+) and transitional
      B cell (CD19+IgDdim CD38+) in peripheral blood mononuclear cells (PBMCs) and
      pleural fluid mononuclear cells (PFMCs) were assessed using multicolor flow
      cytometry. Finally, the associations between BAFF and each sub-group of B cells
      in TPE patients were analyzed. Compared with HC cases, an increased BAFF level
      and elevated frequency of switched B cell were observed in the blood and pleural
      effusion from patients with TPE. The proportions of naive B cell, plasma B cell
      and transitional B cell were lower in the PFMCs of TPE patients. Furthermore, a
      significant correlation was observed between the level of BAFF, and the
      proportion of switched B cell in the peripheral blood and pleural effusion of TPE
      patients. These findings indicated that the B cell profile may be different in
      the pleural effusion, and BAFF may activate switched B cells to enhance the
      humoral immune responses in patients with TPE. Further studies are required to
      elucidate the underlying mechanisms and determine the potential immunotherapy of
      the BAFF-switched B cell axis.

PMID- 29845275
TI  - miR-23a downregulation modulates the inflammatory response by targeting ATG12
      mediated autophagy.
AB  - Autophagy, part of the innate immune defense mechanisms, is activated during the
      initial phase of septic insult. Previous studies indicated that micro (mi)RNAs
      are additionally involved in the host response to sepsis; however, the
      association between miRNAs and autophagy during this process is not fully
      understood. To study the role of miRNA (miR)-23a in autophagy initiated by
      sepsis, macrophages treated with lipopolysaccharides, in addition to blood
      samples from patients, were evaluated for miR-23a expression levels. Cell
      viability, inflammatory mediators and autophagic markers were investigated
      following overexpression or inhibition of miR-23a. The results suggested that miR
      23a was suppressed subsequent to septic insult, promoting autophagy and
      suppressing a hyper inflammatory response, leading to enhanced cell viability. A
      luciferase assay and western blot analysis confirmed ubiquitin-like protein ATG12
      to be the target of miR-23a. The present study revealed that the downregulation
      of miR-23a regulates an inflammatory response during septic insult via autophagy
      promotion.

PMID- 29845276
TI  - Response of hPDLSCs on 3D printed PCL/PLGA composite scaffolds in vitro.
AB  - Three-dimensional printed (3DP) scaffolds have become an excellent resource in
      alveolar bone regeneration. However, selecting suitable printable materials
      remains a challenge. In the present study, 3DP scaffolds were fabricated using
      three different ratios of poly (epsilon-caprolactone) (PCL) and poly-lactic-co
      glycolic acid (PLGA), which were 0.1PCL/0.9PLGA, 0.5PCL/0.5PLGA and
      0.9PCL/0.1PLGA. The surface characteristics and degradative properties of the
      scaffolds, and the response of human periodontal ligament stem cells (hPDLSCs) on
      the scaffolds, were assessed to examine the preferable ratio of PCL and PLGA for
      alveolar bone regeneration. The results demonstrated that the increased
      proportion of PLGA markedly accelerated the degradation, smoothed the surface and
      increased the wettability of the hybrid scaffold. Furthermore, the flow cytometry
      and Cell Counting Kit-8 assay revealed that the adhesion and proliferation of
      hPDLSCs were markedlyincreased on the 0.5PCL/0.5PLGA and 0.1PCL/0.9PLGA
      scaffolds. Additionally, the alkaline phosphatase activity detection and reverse
      transcription quantitative polymerase chain reaction demonstrated that the
      hPDLSCs on the 0.5PCL/0.5PLGA scaffold exhibited the best osteogenic capacity.
      Consequently, PCL/PLGA composite scaffolds may represent a candidate focus for
      future bone regeneration studies, and the 0.5PCL/0.5PLGA scaffold demonstrated
      the best bio-response from the hPDLSCs.

PMID- 29845277
TI  - Acid fibroblast growth factor facilitates the progression of atherosclerotic
      plaques regardless of alterations in serum lipid expression levels in HFD-fed
      ApoE-/- mice.
AB  - Atherosclerosis is recognized at present as a chronic metabolic disease of the
      arteries that leads to multifocal plaque development. Previous studies have
      reported that acid fibroblast growth factor (aFGF) is a critical therapeutic
      regulator in numerous chronic metabolic disorders. However, there is currently no
      direct evidence indicating whether aFGF serves a therapeutic role in
      atherosclerosis. In the present study, the role of aFGF in atherosclerotic lesion
      development was investigated by examining high-fat diet (HFD)-fed apolipoprotein
      E (ApoE)-/- mice and parenteral administration of aFGF. Increased expression of
      aFGF and peroxisome proliferator-activated receptor alpha (PPARalpha) was
      observed during atherosclerotic lesion development. The parenteral delivery of
      aFGF facilitated the progression of atherosclerosis without altering serum lipid
      expression levels in HFD-fed ApoE-/- mice. Furthermore, it was demonstrated that
      aFGF increased the expression of PPARalpha and inflammatory cytokines. The
      present results provided evidence that aFGF accelerates the progression of
      atherosclerosis and suggested that aFGF may be a potential therapeutic target for
      the prevention of atherosclerosis development.

PMID- 29845278
TI  - Baicalein inhibits osteosarcoma cell proliferation and invasion through the miR
      183/Ezrin pathway.
AB  - Osteosarcoma (OS), a common and primary malignant bone tumor, is characterized by
      highly aggressive potency. Baicalein, a bioactive flavone isolated from
      Scutellaria baicalensis Georgi, has been shown to inhibit the progression of
      numerous tumors, including OS. However, the mechanisms by which baicalein
      protects against OS are still largely unknown. The results of the present study
      showed that administration of baicalein significantly inhibited the
      proliferation, migration and invasion and promoted apoptosis in MG-63 and Saos-2
      cells. Ezrin was identified as a target gene of microRNA (miR)-183. MG-63 and
      Saos-2 cells treated with baicalein exhibited increased miR-183 levels and
      decreased Ezrin expression. Importantly, miR-183 inhibition and Ezrin
      overexpression abolished the effects of baicalein on MG-63 and Saos-2 cell
      proliferation, migration, invasion and apoptosis. Taken together, these findings
      suggest that baicalein inhibits the proliferation, migration and invasion and
      induces apoptosis in OS cells by activating the miR-183/Ezrin pathway, revealing
      a novel mechanism underlying anti-OS effects of baicalein.

PMID- 29845279
TI  - Salvianolic acid B reverses multidrug resistance in nude mice bearing human colon
      cancer stem cells.
AB  - Salvianolic acid B (SalB) is a water-soluble phenolic compound, extractable from
      Salvia miltiorrhiza, and has previously been demonstrated to reverse tumor
      multidrug resistance (MDR) in colon cancer cells. Cancer stem cells (CSCs) are
      closely associated with drug resistance. Therefore, establishing a nude mouse
      model bearing human colon CSCs is important for the study of the mechanisms
      underlying colon cancer drug resistance as well as the reversal of drug
      resistance. The present study aimed to establish a nude mouse model bearing human
      colon CSCs and to investigate the effects of SalB on the drug resistance
      exhibited by the nude mouse model as well as determine its underlying mechanism.
      Cells from two colon cancer cell lines (LoVo and HCT-116) were cultured in serum
      free medium to obtain CSCs-enriched spheroid cells. Following this, nude mice
      were transplanted with LoVo and HCT-116 colon CSCs to establish the CSC nude
      mouse model, which was subsequently demonstrated to exhibit MDR. The results of
      the present study revealed that following treatment with SalB, the
      chemotherapeutic drug resistance of xenografts was reversed to a certain extent.
      Western blot analysis was performed to investigate the expression levels of
      cluster of differentiation (CD)44, CD133, transcription factor sox-2 (SOX2) and
      ATP-binding cassette sub-family G member 2 (ABCG2) proteins, and the results
      demonstrated that treatment with SalB downregulated the expression of CD44, SOX2
      and ABCG2 proteins in both LoVo and HCT-116 colon CSCs xenografts. In conclusion,
      the results of the present study revealed that a serum-free suspension method can
      be performed to successfully isolate colon CSCs. In addition, a nude mice bearing
      colon CSCs animal model was successfully established, and associated tumors were
      confirmed to exhibit MDR. Furthermore, SalB was demonstrated to successfully
      reverse MDR in nude mice bearing LoVo and HCT-116 colon CSCs, as well as suppress
      the expression of CD44, SOX2 and ABCG2 proteins.

PMID- 29845280
TI  - Oxidative stress modulates the expression of toll-like receptor 3 during
      respiratory syncytial virus infection in human lung epithelial A549 cells.
AB  - Toll-like receptor 3 (TLR3) can react with double stranded RNA and is involved in
      the inflammatory response to respiratory syncytial virus (RSV) infection. Also,
      oxidative stress has been reported to be involved in RSV infection. However, the
      correlation between oxidative stress and TLR3 activation during RSV infection is
      unclear. Therefore, the present study investigated the association between TLR3
      expression and oxidative stress modulation during RSV infection in A549 cells.
      For comparison, seven treatment groups were established, including RSV-treated
      cells, N-acetyl-L-cysteine (NAC)+RSV-treated cells, oxidant hydrogen peroxide
      (H2O2)+RSV-treated cells, normal cell control, inactivated RSV control, NAC
      control and H2O2 control. The mRNA expression changes of TLR3, interferon
      regulatory factor-3 (IRF3), nuclear factor-kappaB (NF-kappaB) and superoxide
      dismutase 1 (SOD1) were measured using semi-quantitative reverse transcription
      polymerase chain reaction, and the protein changes of TLR3 and phospho-NF-kappaB
      p65 were determined using western blot in A549 cells from the different treatment
      groups. The present study also evaluated the differences in hydroxyl free radical
      (.OH), nitric oxide (NO) and total SOD activity in the different treatment
      groups. The results demonstrated that RSV infection of A549 cells increased the
      levels of .OH and NO, while decreasing the activity of total SOD. Pretreatment of
      A549 cells with H2O2 prior to RSV infection upregulated the mRNA and protein
      expression of TLR3 and NF-kappaB, and downregulated the mRNA expression of IRF3
      and SOD1, as well as the total SOD activity. When the infected cells were
      pretreated with NAC, the mRNA and protein expression of these genes were
      reversed. These variations in the TLR3-mediated signaling pathway molecules
      suggested that oxidative stress may be a key regulator for TLR3 activation during
      RSV infection. RSV-induced oxidative stress may potentially activate TLR3 and
      enhance TLR3-mediated inflammation. These results may provide better
      understanding of the RSV-induced inflammatory and immune pathways, and may also
      contribute to the drug development and prevention of human RSV diseases.

PMID- 29845281
TI  - miR-205 targets YAP1 and inhibits proliferation and invasion in thyroid cancer
      cells.
AB  - MicroRNA-205 (miR-205) has been reported to be downregulated, and serves critical
      roles in the pathogenesis and progression of several types of cancer, including
      breast, prostate and lung cancer. However, the underlying mechanism of miR-205 in
      thyroid cancer remains unclear. In the present study, it was demonstrated that
      the expression of miR-205 was reduced in thyroid cancer tissues compared with non
      cancer tissues. In addition, miR-205-knockdown models in the BHT-101 cell line
      and ectopic expression models in the 8505-C cell line were used to measure the
      biological functions of miR-205. The results indicated that miR-205 inhibited
      certain aspects of thyroid cancer, including cell proliferation, migration and
      invasion. Furthermore, Yes-associated protein 1 (YAP1) was identified as a target
      gene of miR-205 and its expression was negatively correlated with that of miR-205
      in thyroid cancer tissues. Depletion of YAP1 partially reduced the anti-miR-205
      induced cell growth and invasion. The results of the present study suggested that
      the tumor suppressive functions of miR-205 via targeting YAP1 could be a novel
      target for the treatment of thyroid cancer.

PMID- 29845282
TI  - MicroRNA-152 inhibits cell proliferation of osteosarcoma by directly targeting
      Wnt/beta-catenin signaling pathway in a DKK1-dependent manner.
AB  - The function of microRNA-152 for a cohort of patients with osteosarcoma and the
      influence on cell growth of osteosarcoma were studied. The expression of microRNA
      152 was downregulated in patients with osteosarcoma. The downregulation of
      microRNA-152 promotes cell proliferation, decreases apoptosis, and suppresses LDH
      activity, caspase-3/9 activities and Bax/Bcl-2 and p53 protein expression levels
      of osteosarcoma through activation of the Wnt/beta-catenin signaling pathway by
      targeting DKK1. Whereas, overexpression of microRNA-152 targets DKK1 to inhibit
      cell proliferation, induce apoptosis, and promote LDH activity, caspase-3/9
      activities and Bax/Bcl-2 and p53 protein expression levels of osteosarcoma
      through inactivation of the Wnt/beta-catenin signaling pathway. The promotion of
      DKK1 reversed the anticancer function of microRNA-152 over-expression through
      Wnt/beta-catenin signaling pathway. We demonstrated that microRNA-152 inhibits
      cell proliferation of osteosarcoma through DKK1 by directly targeting Wnt/beta
      catenin signaling pathway.

PMID- 29845283
TI  - E-cadherin regulates proliferation of colorectal cancer stem cells through NANOG.
AB  - Cancer stem cells (CSCs) possess a self-renewal ability and display tumorigenic
      potential in immunodeficient mice. Colorectal CSCs are thought to be a uniform
      population and no functionally distinct subpopulations have been identified.
      Because E-cadherin is an essential molecule for self-renewal of embryonic stem
      cells, we examined E-cadherin expression, which may play a role in maintaining
      the properties of CSCs, in EpCAMhigh/CD44+ colorectal CSCs from human primary
      colorectal cancers. We obtained 18 surgical specimens of human primary colorectal
      cancer. CD44, EpCAM, and E-cadherin expression were analyzed by fluorescence
      activated cell sorting. Sorted EpCAMhigh/CD44+ colorectal CSCs were injected into
      immunodeficient mice to estimate the tumorigenic potential. Genetic profiles were
      analyzed by cDNA microarray. Notably, colorectal CSCs could be divided into two
      populations based on the E-cadherin expression status, and they exhibited
      different pathological characteristics. Compared to E-cadherin-negative
      colorectal CSCs, E-cadherin-positive (EC+) colorectal CSCs demonstrated higher
      tumor growth potential in vivo. EC+ colorectal CSCs revealed a higher expression
      of the pluripotency factor NANOG, which contributed to the higher tumor growth
      potential of EC+ colorectal CSCs through control of cyclin D1 expression. These
      findings are the first demonstration of functionally distinct subpopulations of
      colorectal CSCs in human clinical samples.

PMID- 29845284
TI  - Linarin prevents LPS-induced acute lung injury by suppressing oxidative stress
      and inflammation via inhibition of TXNIP/NLRP3 and NF-kappaB pathways.
AB  - Acute lung injury (ALI) is an important cause of morbidity and mortality for
      critically ill patients, and linarin (LR) may be a potential treatment for ALI as
      it reportedly has antioxidant, anti-inflammatory and apoptotic-regulating
      activity. In the present study, the authors report that saline and LR (12.5, 25
      and 50 mg/kg) were applied to male C57BL/6 mice via gavage. Then, mice were
      intratracheally injected with either saline or lipopolysaccharide (LPS). LR
      pretreatment attenuated LPS-induced ALI and platelet activation and reduced CD41
      expression levels and neutrophil platelet aggregates. Additionally, LPS-triggered
      pulmonary myeloperoxidase activity and neutrophil infiltration in lung tissues,
      and this was eliminated by LR dose-dependently. Furthermore, LPS-induced
      oxidative stress and pro-inflammatory cytokine release were downregulated by LR
      by inhibiting thioredoxin-interacting protein and nuclear factor-kappaB signaling
      pathways, including their downstream and upstream signals, such as xanthine
      oxidase, NLR family WHAT, pyrin domain-containing 3 (NLRP3), apoptosis-associated
      speck-like protein containing a C-terminal caspase recruitment domain (ASC),
      caspase-1, IkappaB kinase-alpha (IKK-alpha) and IkappaBalpha. Moreover, in LPS
      induced mice, the mitogen-activated protein kinase pathway was inactivated by LR.
      In vitro, LR reduced LPS-induced inflammation and oxidative stress, which was
      linked to reduction of ROS. In conclusion, LR pretreatment may be protective
      against LPS-induced ALI.

PMID- 29845285
TI  - RAD52 motif-containing protein 1 promotes non-small cell lung cancer cell
      proliferation and survival via cell cycle regulation.
AB  - DNA repair proteins such as RAD52 have been implicated in tumor progression and
      response to chemotherapy. RAD52 motif-containing protein 1 (RDM1) has been
      implicated in the response to chemotherapeutic agent cisplatin; however, its
      function in lung cancer progression remains unclear. This study aimed to
      investigate the role of RDM1 in the progression of non-small cell lung cancer
      (NSCLC). We found elevated RDM1 mRNA and protein expression in NSCLC tissues and
      cell lines compared to levels in normal lung cells. RDM1 protein expression in
      lung cancer tissues was found to correlate with tumor size, histological
      differentiation, lymph node metastasis and tumor-node-metastasis (TNM) stage.
      Knockdown of the RDM1 gene with siRNA significantly reduced the cellular
      proliferation rate and increased apoptosis in the human NSCLC cell line, NCI
      H1299. Compared to wild-type NCI-H1299 cells, RDM1 knockdown enhanced the
      activity of caspase-3 and caspase-7, and decreased the proportion of cells in the
      S-phase of the cell cycle. Taken together, these data imply that RDM1 promotes
      the survival and proliferation of NSCLC cells. Due to its similarity to RAD52, we
      hypothesized that RDM1 potentially repairs DNA double-strand breaks arising
      through DNA replication, thereby preventing G2/M cell cycle arrest. Accordingly,
      specific targeting of RDM1 may be a novel therapeutic strategy in the treatment
      of NSCLC.

PMID- 29845287
TI  - Antitumor effect of lapatinib and cytotoxic agents by suppression of E2F1 in HER2
      positive breast cancer.
AB  - The human epidermal growth factor receptor 2 (HER2)-targeting agent, lapatinib,
      combined with oral fluoropyrimidine capecitabine, has been previously
      demonstrated to be an effective treatment option for patients with trastuzumab
      resistant HER2-positive metastatic breast cancer. To investigate the molecular
      mechanisms associated with the interactions between lapatinib and capecitabine,
      the effect of treatment with lapatinib and phosphatidylinositol-4,5-bisphosphate
      3-kinase (PI3K) inhibitors on the expression of E2F transcription factor 1 (E2F1)
      and thymidylate synthase (TS), which is associated with an increased response to
      5-fluorouracil (5-FU)-based chemotherapy, was determined in HER2-positive breast
      cancer cells. The results of reverse transcription-quantitative polymerase chain
      reaction demonstrated that administration of lapatinib and PI3K inhibitors
      decreased the mRNA expression of TS and E2F1, a transcription factor that
      promotes TS gene expression, in SKBR3 and T47D cell lines. Furthermore, treatment
      with lapatinib and PI3K inhibitors also suppressed the mRNA expression of
      ribonucleotide reductase M1 subunit (RRM1), an important determinant of
      gemcitabine resistance, and DNA topoisomerase II-alpha (TOP2A), a molecular
      target of anthracyclines, in SKBR3 and T47D cell lines. Western blot analysis
      further demonstrated that the phosphorylation of Akt was inhibited by lapatinib,
      and the results of the MTT assay revealed that the combination of lapatinib with
      either 5-FU or gemcitabine demonstrated synergistic antitumor effects, whereas a
      combinatory treatment of lapatinib with epirubicin, a typical anthracycline drug,
      exhibited antagonistic antitumor effects in HER2-positive breast cancer cells.
      These results indicate that the synergistic antitumor effects exhibited by
      combinatory treatment of lapatinib with capecitabine may be induced via the
      suppression of E2F1-mediated TS expression.

PMID- 29845286
TI  - Computational approaches for predicting key transcription factors in targeted
      cell reprogramming (Review).
AB  - There is a need for specific cell types in regenerative medicine and biological
      research. Frequently, specific cell types may not be easily obtained or the
      quantity obtained is insufficient for study. Therefore, reprogramming by the
      direct conversion (transdifferentiation) or re-induction of induced pluripotent
      stem cells has been used to obtain cells expressing similar profiles to those of
      the desired types. Therefore, a specific cocktail of transcription factors (TFs)
      is required for induction. Nevertheless, identifying the correct combination of
      TFs is difficult. Although certain computational approaches have been proposed
      for this task, their methods are complex, and corresponding implementations are
      difficult to use and generalize for specific source or target cell types. In the
      present review four computational approaches that have been proposed to obtain
      likely TFs were compared and discussed. A simplified view of the computational
      complexity of these methods is provided that consists of three basic ideas: i)
      The definition of target and non-target cell types; ii) the estimation of
      candidate TFs; and iii) filtering candidates. This simplified view was validated
      by analyzing a well-documented cardiomyocyte differentiation. Subsequently, these
      reviewed methods were compared when applied to an unknown differentiation of
      corneal endothelial cells. The generated results may provide important insights
      for laboratory assays. Data and computer scripts that may assist with direct
      conversions in other cell types are also provided.

PMID- 29845288
TI  - FGF21 attenuates hypoxia-induced dysfunction and apoptosis in HPAECs through
      alleviating endoplasmic reticulum stress.
AB  - Vascular endothelial apoptosis and dysfunction have a crucial role in triggering
      pathological vascular remodeling of hypoxia-induced pulmonary arterial
      hypertension (PAH). Fibroblast growth factor (FGF)21, an endocrine regulator, has
      recently been reported to protect cardiac endothelial cells from damage and
      suppress inflammatory responses. In addition, FGF21 is reported to be involved in
      endoplasmic reticulum stress (ERS). Previous studies have suggested that ERS
      participates in the development of PAH, and attenuation of ERS could be an
      effective therapeutic strategy for the protection of pulmonary arteries. However,
      whether FGF21 has a protective function via suppression of ERS in pulmonary
      arterial endothelial cells in hypoxia remains unclear. The present study aimed to
      explore whether FGF21 could reduce the hypoxia-induced apoptosis of human
      pulmonary arterial endothelial cells (HPAECs) and prevent endothelial dysfunction
      via the inhibition of ERS. HPAECs were divided into six groups: Normoxia,
      hypoxia, hypoxia plus FGF21, hypoxia plus salubrinal (an ERS inhibitor), hypoxia
      plus tunicamycin (an ERS agonist), and hypoxia plus tunicamycin plus FGF21. The
      endoplasmic reticulum ultrastructure in HPAECs was assessed by transmission
      electron microscopy, and proliferation and apoptosis were examined by cell
      counting kit-8 and terminal deoxyribonucleotide transferase-mediated dUTP nick
      end-labelling assays, respectively. The expression levels of ERS-related
      proteins, including binding immunoglobulin protein (BiP), protein kinase R-like
      endoplasmic reticulum kinase (PERK), phosphorylated (p-) PERK, transcription
      factor C/EBP homologous protein (CHOP), B-cell lymphoma-2 (Bcl-2) and caspase-4
      were detected by western blotting. Transwell migration chamber assays were
      performed, and the concentration of nitric oxide (NO)/endothelin-1 (ET-1) in the
      culture medium was determined to examine endothelial function. The results
      revealed that hypoxia increased the % of apoptotic cells and diminished the
      viability of HPAECs, accompanied by an upregulation of ERS-dependent apoptosis by
      increasing the expression of the proapoptotic caspase-4 and decreasing the
      antiapoptotic Bcl-2. Additionally, hypoxia upregulated the expression of
      representative proteins in the PERK branch of ERS, including BiP, p-PERK and
      CHOP, while it downregulated the expression of PERK. Furthermore, the secretion
      of NO/ET-1 and the migration rate of HPAECs were downregulated under conditions
      of hypoxia. FGF21 significantly attenuated the hypoxia-induced apoptosis and
      dysfunction of HPAECs through alleviating the aforementioned changes in ERS
      dependent signaling pathways. In conclusion, ERS may be a crucial mechanism in
      the hypoxia-induced apoptosis and endothelial dysfunction of HPAECs. FGF21 may
      attenuate the hypoxia-induced apoptosis and dysfunction of HPAECs through
      alleviating ERS, via the PERK/CHOP signaling pathway and inhibition of caspase-4
      expression.

PMID- 29845289
TI  - Dual mTOR/PI3K inhibitor NVP-BEZ235 arrests colorectal cancer cell growth and
      displays differential inhibition of 4E-BP1.
AB  - The mammalian target of rapamycin (mTOR), a downstream effector of the PI3K/Akt
      signalling pathway, is a critical regulator of cell metabolism, growth and
      survival in response to oncogenic factors. Activation of mTOR frequently occurs
      in human tumours making it a crucial and validated target in the treatment of
      cancer. mTOR inhibitors such as rapamycin and its analogues decrease cancer
      progression in experimental models including colorectal cancer (CRC). Recently,
      the second generation ATP-competitive mTOR kinase (such as PP242) and dual
      mTOR/PI3K (such as NVP-BEZ235) inhibitors have entered clinical trials as
      anticancer agents. However, in CRC, the efficacy of these novel drugs needs to be
      fully investigated. In the present study, we examined five human CRC cell lines,
      HT29, HCT116, SW480, SW620 and CSC480 to evaluate their sensitivity to three mTOR
      inhibitors, RAD001, PP242 and NVP-BEZ235. We observed that compared to RAD001 and
      PP242, NVP-BEZ235 markedly reduced cell proliferation of CRC cells. Furthermore,
      we found that the reduced cell proliferation caused by NVP-BEZ235 was not
      achieved through the disruption of mitochondrial potential. Using an mTOR
      specific signalling pathway phospho array we revealed that NVP-BEZ235
      significantly decreased phosphorylation of 4E-BP1 (Thr70), the downstream target
      of mTORC1. In addition, NVP-BEZ235 decreased phosphorylation of AKT (Ser473), the
      downstream target of mTORC2. Immunoblotting analysis revealed that NVP-BEZ235
      effectively inhibited 4E-BP1 phosphorylation, while PP242 had a weak inhibitory
      effect. However, PP242 and NVP-BEZ235 decreased AKT levels in all cell lines.
      RAD001 demonstrated no effect on 4E-BP1. Based on the above-mentioned results,
      the dual PI3K/mTOR and ATP-competitive mTOR inhibitors have demonstrated high
      potential for targeting the mTOR pathway in CRC.

PMID- 29845290
TI  - Rapamycin and ZSTK474 can have differential effects at different post-infection
      time-points regarding CVB3 replication and CVB3-induced autophagy.
AB  - Coxsackievirus B3 (CVB3) infection has been shown to stimulate autophagy. We have
      demonstrated that the inhibition of phosphoinositide 3-kinase (PI3K)/protein
      kinase B/mammalian target of rapamycin complex (mTORC) signaling pathway could
      affect the autophagic reaction induced by CVB3 infection in our previous study.
      However, the processes associating autophagy and CVB3 replication remain to be
      determined. In the present study, CVB3-induced autophagy and its impact on viral
      replication were investigated. Rapamycin (inhibitor of mTOR) and ZSTK474
      (inhibitor of PI3K) were used to change the autophagic reaction caused by CVB3 in
      Hela cells at different post-infection (p.i.) time points (6, 9, 12 and 24 h
      p.i.), meanwhile, we detected the CVB3 mRNA replication and CVB3 capsid protein
      VP1 expression following the change of autophagy. Here, it was showed that
      ZSTK474 and Rapamycin promoted CVB3-induced autophagy, as well as decreasing CVB3
      mRNA replication and CVB3 capsid protein VP1 expression at 6 and 9 h p.i. ZSTK474
      also alleviated CVB3-induced autophagy, and decreased CVB3 mRNA replication and
      VP1 expression at 12 and 24 h p.i. However, Rapamycin continued to promote CVB3
      induced autophagy and increase CVB3 mRNA replication at 12 and 24 h p.i, as well
      as increase VP1 expression at 12 h, but not at 24 h, p.i. In the present study,
      we found Rapamycin and ZSTK474 have differential effects at different p.i. time
      points regarding CVB3 replication and CVB3-induced autophagy. This indicates that
      the association between CVB3-induced autophagy and viral replication depends on
      the infection time. During the early course of infection, autophagy may help host
      cells clear the virus, thereby providing protection, whereas when the infection
      time increases, autophagy may be exploited for viral replication.

PMID- 29845291
TI  - Concomitant presence of JAK2V617F mutation and BCR-ABL translocation in two
      patients: A new entity or a variant of myeloproliferative neoplasms (Case
      report).
AB  - Myeloproliferative neoplasms (MPNs) are classically divided into BCR RhoGEF and
      GTPase activating protein (BCR)-ABL proto-oncogene 1 non-receptor tyrosine kinase
      (ABL) positive chronic myeloid leukemia (CML) and BCR-ABL negative MPNs,
      including essential thrombocythemia (ET). One of the major diagnostic criteria
      for ET is the absence of the philadelphia chromosome, thus when present it is
      almost indicative of CML. ET and CML are considered to be mutually exclusive;
      however, there are rare situations in which patients with ET present positive BCR
      ABL without the features of CML. Although from the literature review, the
      frequency of JAK2V617F mutation and BCR-ABL translocation coexistence in MPNs is
      low, it may be higher than expected. The current study reported cases of two
      patients with an initial diagnosis of ET in the presence of JAK2V617F mutation
      and BCR-ABL translocation by fluorescent in situ hybridization. Both patients
      presented with a heterozygous BCR-ABL translocation, and absence of p190 and p210
      transcripts, seemingly a der(9) in the background of an ET JAK2V617F mutation.

PMID- 29845292
TI  - Regulation of TLR4 expression mediates the attenuating effect of erythropoietin
      on inflammation and myocardial fibrosis in rat heart.
AB  - The mechanism underlying the anti-inflammatory or antifibrotic activity of
      erythropoietin (EPO) in myocardial fibrosis (MF) remains elusive. In the current
      study, abdominal aortic constriction (AAC) was performed on rats and EPO and/or
      Toll-like receptor (TLR)4 were overexpressed in rat hearts through
      intramyocardial administration of lentivirus expressing the EPO and TLR4 genes.
      Hematoxylin and eosin staining and Masson's trichrome staining were performed on
      tissue sections from rat hearts for histopathological examination. ELISA was used
      to determine the levels of inflammatory mediators in serum. Gene expression
      levels were determined by quantitative polymerase chain reaction analysis and
      protein expression levels were determined by western blot analysis and
      immunofluorescence staining. The results indicated that EPO overexpression
      improved MF in rat hearts, by inhibiting the release of transforming growth
      factor (TGF)-beta1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL
      1beta, IL-17A, matrix metalloproteinase (MMP)-9 and MMP-2. Moreover, EPO
      overexpression suppressed the expression of TLR4, while promoting
      phosphoinositide 3-kinase (PI3K) and phosphorylated AKT serine/threonine kinase 1
      (Akt) expression levels. However, the beneficial effects of EPO were attenuated
      by overexpression of TLR4. In addition, inhibition of PI3K/Akt signaling activity
      by treatment with LY294002 markedly reversed the protective effect of EPO on the
      AAC-induced MF. Taken together, the present study demonstrated that EPO may have
      a critical role against MF by activating PI3K/Akt signaling and by downregulating
      TLR4 expression, thereby inhibiting the release of TGF-beta1, TNF-alpha, IL-6, IL
      1beta, IL-17A, MMP-9 and MMP-2. These findings suggest that the PI3K/Akt/TLR4
      signaling pathway is associated with the anti-inflammatory effects of EPO and may
      play a role in attenuating AAC-induced MF.

PMID- 29845293
TI  - MicroRNA-874 inhibits proliferation and invasion of pancreatic ductal
      adenocarcinoma cells by directly targeting paired box 6.
AB  - Studies have demonstrated that a number of microRNAs (miRNAs) are dysregulated in
      pancreatic ductal adenocarcinoma (PDAC), and alterations in their expression may
      affect the onset and progression of PDAC. Therefore, the expression patterns,
      biological functions and associated molecular mechanisms of miRNAs in PDAC should
      be elucidated for the development of novel therapeutic methods. Previous studies
      reported significant miRNA-874 (miR-874) dysregulation in multiple types of human
      cancer. However, the expression pattern, possible roles and underlying mechanisms
      of miR-874 in PDAC remain to be elucidated. This study evaluated miR-874
      expression in PDAC and examined its biological functions and underlying mechanism
      of action in PDAC progression. miR-874 expression was downregulated in PDAC
      tissues and cell lines. Functional experiments demonstrated that upregulation of
      miR-874 inhibited cell proliferation and invasion in PDAC. Additionally, paired
      box 6 (PAX6) was predicted as a putative target of miR-874 using bioinformatics
      analysis. Further experiments demonstrated that PAX6 may be the direct target
      gene of miR-874 in PDAC. PAX6 knockdown exhibited similar inhibitory effects to
      miR-874 overexpression in PDAC cells. In addition, restored PAX6 expression may
      reverse the suppressive roles of miR-874 overexpression in PDAC cells. The
      results demonstrated that miR-874 may serve tumor suppressive roles in PDAC by
      directly targeting PAX6. Therefore, miR-874 may exhibit potential applications
      for treatment of patients with PDAC.

PMID- 29845294
TI  - RNA-sequencing analysis of aberrantly expressed long non-coding RNAs and mRNAs in
      a mouse model of ventilator-induced lung injury.
AB  - Long non-coding RNAs (lncRNAs) are closely associated with the regulation of
      various biological processes and are involved in the pathogenesis of numerous
      diseases. However, to the best of our knowledge, the role of lncRNAs in
      ventilator-induced lung injury (VILI) has yet to be evaluated. In the present
      study, high-throughput sequencing was applied to investigate differentially
      expressed lncRNAs and mRNAs (fold change >2; false discovery rate <0.05).
      Bioinformatics analysis was employed to predict the functions of differentially
      expressed lncRNAs. A total of 104 lncRNAs (74 upregulated and 30 downregulated)
      and 809 mRNAs (521 upregulated and 288 downregulated) were differentially
      expressed in lung tissues from the VILI group. Gene ontology analysis
      demonstrated that the differentially expressed lncRNAs and mRNAs were mainly
      associated with biological functions, including apoptosis, angiogenesis,
      neutrophil chemotaxis and skeletal muscle cell differentiation. The top four
      enriched pathways were the tumor necrosis factor (TNF) signaling pathway, P53
      signaling pathway, neuroactive ligand-receptor interaction and the forkhead box O
      signaling pathway. Several lncRNAs were predicted to serve a vital role in VILI.
      Subsequently, three lncRNAs [mitogen-activated protein kinase kinase 3, opposite
      strand (Map2k3os), dynamin 3, opposite strand and abhydrolase domain containing
      11, opposite strand] and three mRNAs (growth arrest and DNA damage-inducible
      alpha, claudin 4 and thromboxane A2 receptor) were measured by reverse
      transcription-quantitative polymerase chain reaction, in order to confirm the
      veracity of RNA-sequencing analysis. In addition, Map2k3os small interfering RNA
      transfection inhibited the expression of stretch-induced cytokines [TNF-alpha,
      interleukin (IL)-1beta and IL-6] in MLE12 cells. In conclusion, the results of
      the present study provided a profile of differentially expressed lncRNAs in VILI.
      Several important lncRNAs may be involved in the pathological process of VILI,
      which may be useful to guide further investigation into the pathogenesis for this
      disease.

PMID- 29845295
TI  - MicroRNA-663b mediates TAM resistance in breast cancer by modulating TP73
      expression.
AB  - Breast cancer is the second leading cause of cancer-associated mortalities in
      women. Tamoxifen (TAM) is an endocrine therapy commonly used in the treatment of
      patients with breast cancer expressing estrogen receptor alpha. However,
      treatment often ends in failure due to the emergence of drug resistance.
      MicroRNAs (miRNAs), a family of small non-coding RNAs, serve critical roles in
      the regulation of gene expression and cell events. To date, whether miRNA-663b
      could mediate TAM resistance in breast cancer remains unknown. Therefore, the aim
      of the present study was to investigate the role of miRNA-663b in TAM resistance
      in breast cancer. The results demonstrated that miRNA-663b was upregulated in
      breast cancer with TAM resistance. Tumor protein 73 (TP73) was a direct target of
      miRNA-663b, and was negatively regulated by miRNA-663b in MCF-7 cells.
      Furthermore, it was identified that downregulation of miRNA-663b inhibited cell
      proliferation ability and promoted cell apoptosis, resulting in enhanced TAM
      sensitivity. In addition, these findings suggested that TP73 silencing may have
      eliminated the effects of miRNA-663b inhibitor on breast cancer cells. In
      conclusion, the present study verified a novel molecular link between miRNA-663b
      and TP73, and indicated that miRNA-663b may be a critical therapeutic target in
      breast cancer.

PMID- 29845296
TI  - Lysyl oxidase-like 2 is highly expressed in colorectal cancer cells and promotes
      the development of colorectal cancer.
AB  - Colorectal cancer (CRC) is the third most common type of cancer. In the present
      study, the expression and intracellular localization of lysyl oxidase-like 2
      (LOXL2) protein in CRC were examined. Quantitative polymerase chain reaction and
      western blot analysis of LOXL2 mRNA and protein expression was performed for 40
      pairs of CRC tumor and normal mucosa tissue samples. The immunohistochemical
      staining of tissue microarrays was performed to detect LOXL2 protein expression.
      LOXL2 was highly expressed in the extracellular matrix and CRC cells. The
      positive expression of LOXL2 in CRC cells was significantly associated with the
      tumor tumor-node metastasis stage and distant metastasis, while elevated LOXL2
      expression within the CRC cells was an independent prognostic factor in patients
      with CRC. The knockdown of LOXL2 impaired the proliferative and migratory
      abilities of CRC cells in vitro and in vivo, and induced cell cycle arrest and
      apoptosis. These findings indicated that LOXL2 might have an important role in
      CRC.

PMID- 29845298
TI  - MicroRNA-199b promotes cell proliferation and invasion in Wilms' tumour by
      directly targeting Runt-related transcription factor 3.
AB  - Emerging evidence has demonstrated that the deregulation of microRNAs (miRNAs)
      contributes to Wilms' tumour (WT) malignant progression. Therefore, identifying
      the essential miRNAs for WT onset and progression may be a promising therapeutic
      method for patients with this disease. Dysregulation of miRNA-199b (miR-199b)
      serves significant roles in various types of human cancer. However, its
      expression patterns, possible functions and associated mechanisms in WT are
      largely unknown. In the present study, the expression of miR-199b in WT tissues
      was detected by reverse transcription-quantitative polymerase chain reaction (RT
      qPCR) analysis. The biological functions of miR-199b overexpression in WT cells
      were determined using Cell counting kit-8 and Transwell invasion assays. The
      mechanisms underlying the action of miR-199b in WT cells were also investigated
      using bioinformatics analysis, a luciferase reporter assay, RT-qPCR and western
      blot analysis. It was revealed that miR-199b expression was upregulated in WT
      tissues. In addition, the downregulation of miR-199b attenuated the proliferation
      and invasion of WT cells. Runt-related transcription factor 3 (RUNX3) was
      mechanistically predicted as a potential target of miR-199b. Subsequent
      experiments demonstrated that RUNX3 was a direct target gene of miR-199b in WT.
      In addition, the downregulation of RUNX3 in the WT tissues was inversely
      correlated with the miR-199b expression level. The recovered RUNX3 expression
      counteracted the oncogenic roles of miR-199b in WT cells. Therefore miR-199b may
      serve as an oncogene in WT progression by directly targeting RUNX3, thereby
      suggesting that the miR-199b/RUNX3 axis may be a promising therapeutic target for
      patients with WT.

PMID- 29845297
TI  - Downregulation of miR-135a predicts poor prognosis in acute myeloid leukemia and
      regulates leukemia progression via modulating HOXA10 expression.
AB  - MicroRNA-135a (miR-135a) has been shown to exert important roles in various human
      cancer types, such as glioblastoma, thyroid carcinoma and renal carcinoma.
      However, the function of miR-135a in acute myeloid leukemia (AML) remains largely
      unknown. In the present study, it was demonstrated that miR-135a expression was
      significantly downregulated in AML cells compared with normal control cells.
      Furthermore, the downregulation of miR-135a in patients with AML predicted poor
      prognosis. Through functional experiments, overexpression of miR-135a was
      demonstrated to significantly inhibit the proliferation and cell cycle of AML
      cells, while it promoted cellular apoptosis. miR-135a directly targeted HOXA10 in
      AML cells. miR-135a overexpression significantly suppressed the mRNA and protein
      levels of HOXA10 in AML cells. Moreover, there was an inverse association between
      miR-135a expression and HOXA10 level in AML samples. Additionally, by ectopic
      expression of HOXA10, restoration of HOXA10 significantly abolished the effects
      of miR-135a overexpression on AML cell proliferation, cell cycle and apoptosis.
      In conclusion, the present study demonstrated that miR-135a serves as a tumor
      suppressor in AML by targeting HOXA10, and miR-135a may be a promising prognostic
      biomarker for AML patients.

PMID- 29845299
TI  - Dioscin protects against coronary heart disease by reducing oxidative stress and
      inflammation via Sirt1/Nrf2 and p38 MAPK pathways.
AB  - Cardiovascular diseases are common diseases in Sweden as in most countries. In
      2016, 25,700 persons suffered from coronary heart disease (CHD) and 25% of these
      died within 28 days. The present study investigated whether dioscin may exert
      protective effects against CHD-induced heart apoptosis, oxidative stress and
      inflammation in a pig model and the potential underlying mechanisms. Adult pigs
      were used to establish a CHD model group and 80 mg/kg dioscin was administered
      for 4 weeks. Histological analysis and measurement of serum levels of heart
      injury markers demonstrated that 80 mg/kg dioscin markedly alleviated CHD, while
      left ventricular ejection fraction and left ventricular systolic internal
      diameter measurements indicated that 80 mg/kg dioscin also increased heart
      function in the CHD pig model. Furthermore, western blotting demonstrated that 80
      mg/kg dioscin significantly reduced protein levels of apoptosis markers in the
      heart of CHD model pigs, including Bcl-2-associated X and caspase-3, potentially
      via the suppression of poly (ADP-ribose) polymerase 1 (PARP)/p53 expression.
      Additionally, the results of ELISA and western blotting demonstrated that 80
      mg/kg dioscin may reduce oxidative stress and inflammation in CHD model pigs
      through the promotion of sirtuin 1 (Sirt1)/nuclear factor erythroid 2-related
      factor 2 (Nrf2) protein expression and the suppression of PARP/p53 and p38
      mitogen-activated protein kinase (MAPK) expression. The results of the current
      study indicate that dioscin may protect against CHD by regulating oxidative
      stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways.

PMID- 29845300
TI  - miRNA-195 suppresses cell proliferation of ovarian cancer cell by regulating
      VEGFR2 and AKT signaling pathways.
AB  - The present study aimed to investigate the functional effects of microRNA-195 on
      ovarian cancer cells and the underling mechanism involved. Reverse transcription
      quantitative polymerase chain reaction was used to measure the expression of
      microRNA-195 in patients with ovarian cancer. Cell proliferation and apoptosis
      were measured with MTT assay and flow cytometry, respectively. Caspase-3/9
      activity, vascular endothelial growth factor receptor (VEGFR)2 and phosphorylated
      protein kinase B (p-AKT) protein expression were analyzed using caspase-3/9
      activity kits and western blot analysis. The expression of microRNA-195 was
      downregulated in ovarian cancer, compared with the normal control group.
      Furthermore, microRNA-195 suppresses cell proliferation and induced apoptosis of
      ovarian cancer cells. In addition, microRNA-195 suppressed VEGFR2 and p-AKT
      protein expression in ovarian cancer cells. The inhibition of VEGFR2 and p-AKT
      increased the functional effects of microRNA-195 on apoptosis of ovarian cancer
      cells. The results demonstrated that microRNA-195 suppresses cell proliferation
      of ovarian cancer cells through regulation of VEGFR2 and AKT signaling pathways.

PMID- 29845301
TI  - Resveratrol inhibits angiotensin II-induced proliferation of A7r5 cells and
      decreases neointimal hyperplasia by inhibiting the CaMKII-HDAC4 signaling
      pathway.
AB  - Resveratrol has been reported to inhibit vascular smooth muscle cell
      proliferation and neointimal hyperplasia following arterial injury; however, the
      underlying mechanisms remain unclear. The present study was designed to
      investigate the effects of resveratrol on angiotensin II (AngII)-induced
      proliferation of A7r5 cells and explore the molecular mechanisms responsible for
      the observed effects. Resveratrol inhibited cell proliferation and migration, and
      decreased the AngII-induced protein expression of alpha-smooth muscle actin
      (alpha-SMA), proliferating cell nuclear antigen (PCNA) and cyclin-dependent
      kinase 4 (CDK4). Resveratrol inhibited AngII-induced activation of intracellular
      Ca2+/calmodulin-dependent protein kinase II (CaMKII) and histone deacetylases 4
      (HDAC4), as well as blocking AngII-induced cell cycle progression from the G0/G1
      to S-phase. In vivo, 4-weeks of resveratrol treatment decreased the neointima
      area and the neointima/media area ratio in rats following carotid balloon injury.
      Resveratrol also inhibited the protein expression of total and phosphorylated
      CaMKII and HDAC4 in the injured arteries. In conclusion, the present study
      demonstrated that resveratrol attenuated AngII-induced cell proliferation and
      neointimal hyperplasia by inhibiting the CaMKII-HDAC4 signaling pathway. These
      findings suggest that resveratrol may potentially prevent arterial restenosis.

PMID- 29845303
TI  - [Field tests for the beta version of the ICD-11-MMS in Germany: background and
      methods].
AB  - BACKGROUND: The World Health Organization (WHO) has been developing the 11th
      revision of the International Classification of Diseases (ICD) since 2007. ICD-11
      is different from the ICD-10 in volume and structure. Therefore, the WHO planned
      field tests with a coding of diagnoses and cases. OBJECTIVES: To describe the
      background of the field tests and their implementation in Germany. MATERIALS AND
      METHODS: Interested parties were invited to submit proposals through a call to
      the Association of the Scientific Medical Societies (AWMF). The Technology,
      Methods, and Infrastructure for Networked Medical Research (TMF) was responsible
      for the coordination, supported by the German Institute for Medical Documentation
      and Information (DIMDI). The target was a beta version of the ICD-11 for
      Mortality and Morbidity Statistics (ICD-11-MMS), denoted as "draft for quality
      assurance". RESULTS: Eleven field tests were maintained between March and
      September 2017. With the exception of one field test analyzing diagnoses terms
      from the thesaurus of the ICD-10-GM, all field tests focused on a specific
      medical field. Eight different quality criteria were investigated over the 11
      field tests, and 22 of the 27 chapters of the ICD-11-MMS were at least partially
      covered. CONCLUSIONS: Despite the strict time frame, the field tests were
      successfully implemented and concluded in Germany. Mostly, the ICD-11 tools from
      the WHO were used. A high percentage of the ICD chapters were partially covered.
      In summary, it has been demonstrated for the first time that field tests are a
      valuable approach to evaluate the ICD in parallel to its development. However, a
      methodological framework integrating the field tests should be developed, taking
      into account all relevant requirements.

PMID- 29845302
TI  - SIRT1 upregulation protects against liver injury induced by a HFD through
      inhibiting CD36 and the NF-kappaB pathway in mouse kupffer cells.
AB  - Sirtuin 1 (SIRT1) is an NAD(+)-dependent deacetylase, and a critical regulator in
      various metabolic processes, such as non-alcoholic fatty liver disease (NAFLD).
      The present study aimed to investigate whether activating SIRT1 could modulate
      the CD36 and nuclear factor (NF)-kappaB pathways to protect against liver injury
      induced by a high-fat diet (HFD) in mice. A mouse NAFLD model was established by
      administration of a HFD for 8 weeks. During the last 4 weeks, SRT1720, a specific
      SIRT1 activator, was added daily to the HFD feed. The hepatic morphological
      structure was observed using hematoxylin and eosin staining, and the
      ultrastructures in the liver tissue were observed using transmission electron
      microscopy. Protein expression of SIRT1, CD36 and P65 in liver tissues was
      detected by immunohistochemistry. Kupffer cells (KCs) from the livers of the
      mouse models were isolated to determine the mRNA and protein expression of SIRT1,
      CD36 and P65. SIRT1 activation attenuated the HFD-induced liver injury and
      significantly reduced the body weight and the levels of alanine transaminase,
      aspartate aminotransferase, triglyceride, tumor necrosis factor-alpha and
      interleukin-6. We observed an increased expression of SIRT1 in the liver tissues
      from the HFD+SRT1720 group compared with the HFD group. Simultaneously, the
      expression of CD36 and P65 in the liver tissues was downregulated in the
      HFD+SRT1720 group. The mRNA and protein expression of SIRT1 was elevated in the
      HFD+SRT1720 group, whereas the mRNA and protein expression of CD36 and P65 in KCs
      was significantly decreased in the HFD+SRT1720 group. The present study
      demonstrated that SIRT1 activation attenuated HFD-induced liver steatosis and
      inflammation by inhibiting CD36 expression and the NF-kappaB signaling pathway.

PMID- 29845304
TI  - Counseling in urogynecology: A difficult task, or simply good surgeon-patient
      communication?
AB  - Surgical treatments for pelvic organ prolapse (POP) and urinary incontinence (UI)
      have greatly changed in recent years. Prompted by increases in reports of adverse
      outcomes in relation to such treatments, several scientific societies and
      researchers have emphasized providing patients with thorough counseling before
      treating them. Patient-centered communication has become the gold standard for
      excellence in clinical care. This challenges clinicians to be cognizant of their
      patients' perspectives, motivations, expectations, fears, concerns, and social
      contexts to enable them to reach a shared understanding with patients.
      Considering this, urogynecology counseling represents a crucial process through
      which women can gain a clear understanding of their clinical condition and the
      risks and benefits of potential treatment options. However, many urogynecologists
      believe that proposing a treatment and providing only enough detail to secure
      informed consent constitutes counseling. This article is intended to describe
      good counseling for women undergoing urogynecological surgery and to suggest
      optimal methodologies for implementation.

PMID- 29845305
TI  - A prospective study investigating the diagnostic agreement between urodynamics
      and dynamic cystoscopy in women presenting with mixed urinary incontinence.
AB  - INTRODUCTION AND HYPOTHESIS: Patient history is often insufficient to identify
      type of urinary incontinence (UI). Multichannel urodynamic testing (UDS) is often
      used to clarify the diagnosis. Dynamic cystoscopy (DC) is a novel approach for
      testing bladder function. The primary objective of this study was to investigate
      the diagnostic agreement of UDS and DC in evaluating women with mixed urinary
      incontinence (MUI). METHODS: Women presenting with MUI were approached for
      enrollment if UDS and DC were planned for further investigation. Investigators
      were blinded to history and comparative test results. McNemar's test and kappa
      coefficient were calculated to assess agreement between UDS and DC. Receiver
      operating characteristic (ROC) analysis was used to explore the best possible
      filling sensation cutoffs for DC that would best predict the filling sensation
      cutoffs from UDS. RESULTS: Sixty participants were included, of whom, four were
      excluded for protocol violation. For the primary outcome measure of agreement,
      UDS and DC were concordant in 44/56 of stress urinary incontinence (SUI) cases
      (79%) with a kappa= 0.54 and in 43/56 of urinary urge incontinence (UUI) cases
      (77%) with a kappa= 0.54, indicating moderate, nearly substantial agreement. ROC
      analysis identified the best prediction of DC first urge to void as 148 cm3,
      strong urge 215 cm3, and maximum capacity at 246 cm3. These parameters were used
      to compare UDS UUI to DC UUI and resulted in a kappa = 0.61 (p = 0.37),
      indicating substantial agreement. CONCLUSIONS: When compared with UDS, DC shows
      moderate agreement for detection of SUI and substantial agreement for detection
      of UUI.

PMID- 29845306
TI  - [Management of developmental speech-language disorders in children : Part 2:
      Intervention and remediation].
AB  - In the first part of this seminar paper, speech-language development tests were
      presented and the importance of the differential diagnosis of the underlying
      causes of the diagnosed language development disorder was discussed. The second
      part focuses on counseling and training of the parents, as well as the different
      treatment methods used for speech-language therapy for affected children in out-
      and inpatient settings. These procedures should be applied according to the
      individual developmental age. The official guidelines are to be respected,
      especially for medical speech-language therapy. Generally underestimated issues
      are risks and side effects of language and speech therapy, which obviously do
      exist, e. g., as induction of consciousness of the disorder in the treated child.

PMID- 29845307
TI  - [Medical examination: Preparation for ENT specialisation : Part 36].

PMID- 29845311
TI  - The diagnostic performance and interrater agreement of seven CT findings in the
      diagnosis of internal hernia after gastric bypass operation.
AB  - PURPOSE: A reliable and immediate diagnosis of internal hernia is important for
      optimal and timely management of patients with a history of gastric bypass
      surgery. The aims of this study were to evaluate the interrater agreement and
      diagnostic performance characteristics of seven predefined CT findings of
      internal herniation in patients admitted on clinical suspicion of internal
      herniation after laparoscopic Roux-en-Y gastric bypass (LRYGB). METHODS:
      Abdominal CT scans of 117 patients performed on clinical suspicion of internal
      hernia after LRYGB surgery were evaluated by three radiologists (two experts and
      one resident) for the following: (1) Swirl sign, (2) strangulation of superior
      mesenteric vein (SMV), (3) engorged mesenteric vessels and edema, (4) engorged
      lymph nodes, (5) ascites, (6) mushroom sign, (7) hurricane eye sign, and finally
      the overall conclusion. The CT findings were compared to the laparoscopic
      explorative findings. RESULTS: The highest interrater agreements were seen for
      the swirl sign, SMV strangulation, ascites, and overall conclusion (all Kappa
      0.82-0.83). The presence of internal hernia was significantly and independently
      associated with SMV strangulation (OR 18.3; 95% CI 4.3-78.1; p < 0.001) and
      mesenteric edema (OR 5.2; 95% CI 1.4-19.6; p < 0.001) on multivariate analysis,
      while the other CT findings were not independently associated with herniation.
      The highest sensitivity was observed for mesenteric edema (85.0%), while SMV
      strangulation had the highest specificity (94.8%). CONCLUSION: CT is an accurate
      diagnostic tool for detection of internal hernia after LRYGB. SMV strangulation
      and mesenteric edema are highly predictive and easily identified features of
      internal herniation.

PMID- 29845312
TI  - Peritumoral tissue on preoperative imaging reveals microvascular invasion in
      hepatocellular carcinoma: a systematic review and meta-analysis.
AB  - BACKGROUND: Histologic microvascular invasion (MVI) substantially worsens the
      prognosis of patients with hepatocellular carcinoma, and can only be diagnosed
      postoperatively. Preoperative assessment of MVI by imaging has been focused on
      tumor-related features, while peritumoral imaging features have been indicated
      elsewhere to be more accurate. The aim of the present study is to evaluate the
      association between peritumoral imaging features and MVI. METHODS: Literature
      search was performed using the PubMed, Embase, and Cochrane Library databases.
      Summary results of the association between peritumoral imaging features and MVI
      were presented as the odds ratio (OR) and the 95% confidence interval. Meta
      regression and subgroup analyses were performed when heterogeneity was detected.
      Diagnostic accuracy analysis was also conducted for identified features. RESULTS:
      Ten studies were included in the analysis. Moderate and low heterogeneities were
      found among the seven studies on peritumoral enhancement and four studies on
      peritumoral hypointensity on HBP, respectively. Summary results revealed a
      significant association between MVI and peritumoral enhancement (OR 4.04 [2.23,
      7.32], p < 0.05), and peritumoral hypointensity on HBP (OR 10.62 [5.31, 21.26], p
      < 0.05). Diagnostic accuracy analysis revealed high specificity (0.90-0.94) but
      low sensitivity (0.29-0.40) for both features to assess MVI. CONCLUSION: The two
      peritumoral imaging features are significantly associated with MVI. The two
      features highly suggest MVI only when present with a high false negative rate.
      Promotion of their diagnostic efficiency can be a worthwhile task for future
      research.

PMID- 29845314
TI  - Outcomes of circumcision in children with single ventricle physiology.
AB  - PURPOSE: Children with single ventricle physiology (SVP) have been shown to have
      a high morbidity and mortality after non-cardiac surgical procedures. Elective
      circumcision is one of the most common pediatric operations with low morbidity
      and mortality. The purpose of our study was to review our institutional
      experience with SVP children undergoing circumcisions to determine peri-operative
      course and outcomes. METHODS: We performed a retrospective review of children
      with SVP who underwent an elective circumcision from 2000 to 2017. Children with
      non-single ventricle physiology or children undergoing circumcision in
      combination with another case were excluded. Demographics, surgical
      characteristics, and outcomes were analyzed. Descriptive statistics were
      performed, all medians were reported with interquartile range. RESULTS: 15 males
      underwent elective circumcision with a median age at the time of surgery of 1.13
      (1.03, 1.38) years. Eighty-four percent underwent their circumcision after their
      2nd stage cardiac operation. Most common operative indication was uncomplicated
      phimosis. Median operative time was 20 (16, 27) mins. Median total length of stay
      was 229 (185, 242) mins with no admissions. Post-operative complications included
      two (16%) hematomas with one requiring surgical intervention. There were no
      deaths. CONCLUSION: Children with SVP who undergo elective circumcision may have
      a higher risk of bleeding.

PMID- 29845313
TI  - Medial prefrontal cortex TRPV1 and CB1 receptors modulate cardiac baroreflex
      activity by regulating the NMDA receptor/nitric oxide pathway.
AB  - The ventral medial prefrontal cortex (vMPFC) facilitates the cardiac baroreflex
      response through N-methyl-D-aspartate (NMDA) receptor activation and nitric oxide
      (NO) formation by neuronal NO synthase (nNOS) and soluble guanylate cyclase (sGC)
      triggering. Glutamatergic transmission is modulated by the cannabinoid receptor
      type 1 (CB1) and transient receptor potential vanilloid type 1 (TRPV1) receptors,
      which may inhibit or stimulate glutamate release in the brain, respectively.
      Interestingly, vMPFC CB1 receptors decrease cardiac baroreflex responses, while
      TRPV1 channels facilitate them. Therefore, the hypothesis of the present study is
      that the vMPFC NMDA/NO pathway is regulated by both CB1 and TRPV1 receptors in
      the modulation of cardiac baroreflex activity. In order to test this assumption,
      we used male Wistar rats that had stainless steel guide cannulae bilaterally
      implanted in the vMPFC. Subsequently, a catheter was inserted into the femoral
      artery, for cardiovascular recordings, and into the femoral vein for assessing
      baroreflex activation. The increase in tachycardic and bradycardic responses
      observed after the microinjection of a CB1 receptors antagonist into the vMPFC
      was prevented by an NMDA antagonist as well as by the nNOS and sGC inhibition. NO
      extracellular scavenging also abolished these responses. These same
      pharmacological manipulations inhibited cardiac reflex enhancement induced by
      TRPV1 agonist injection into the area. Based on these results, we conclude that
      vMPFC CB1 and TRPV1 receptors inhibit or facilitate the cardiac baroreflex
      activity by stimulating or blocking the NMDA activation and NO synthesis.

PMID- 29845315
TI  - Does muscle biopsy change the treatment of pediatric muscular disease?
AB  - BACKGROUND: Muscle biopsy is performed to confirm the diagnosis of neuromuscular
      disease and guide therapy. The purpose of our study was to determine if muscle
      biopsy changed patient diagnosis or treatment, which patients were most likely to
      benefit from muscle biopsy, and complications resulting from muscle biopsy.
      MATERIALS AND METHODS: An IRB-approved retrospective chart review of all patients
      less than 18 years old undergoing muscle biopsy between January 2010 and August
      2016 was performed. Demographics, patient presentation, diagnosis, treatment,
      hospital course, and follow-up were evaluated. Descriptive and comparative
      (student's t test, Mann-Whitney U, and Fisher's exact test) statistical analysis
      was performed. Medians were reported with interquartile range (IQR). RESULTS: 90
      patients underwent a muscle biopsy. The median age at biopsy was 5 years (2, 10).
      37% (n = 34) had a definitive diagnosis. 39% (n = 35) had a change in their
      diagnosis. 37% (n = 34) had a change in their treatment course. In the 34
      patients who had a change in their treatment, the most common diagnosis was
      inflammatory disease at 44% (n = 15). In the 56 patients who did not have a
      change in treatment, the most common diagnosis was hypotonia at 30% (n = 17).
      There was no difference in patients who had a change in treatment based on
      pathology versus those that did not. The median length of follow-up was 3 years
      (1, 5). CONCLUSIONS: Muscle biopsy should be considered to diagnose patients with
      symptoms consistent with inflammatory or dystrophic muscular disease. The
      likelihood of this altering the patient's treatment course is around 40%.

PMID- 29845316
TI  - Adenosine hypersensitivity and atrioventricular block.
AB  - Adenosine is a ubiquitous substance that is released under several physiological
      and pathological conditions and has cardiovascular effects including
      cardioinhibition and vasodilation. It has been shown to be an important modulator
      implicated in several forms of syncope. In patients with chronic low plasma
      levels of adenosine, a transient release of endogenous adenosine can be
      sufficient to block conduction in the atrioventricular node and induce prolonged
      asystole; conversely, when plasma adenosine levels are chronically high,
      adenosine release is responsible for vasodepression. Distinct purinergic profiles
      in patients presenting with syncope have recently been correlated with the
      clinical presentation: "low-adenosine patients," prone to asystole, may present
      with idiopathic atrioventricular block, carotid sinus syndrome, or syncope with
      no or very brief prodromes and normal heart; "high-adenosine patients," prone to
      vasodilation, experience vasovagal syncope. This pathophysiological
      classification may have therapeutic implications.

PMID- 29845317
TI  - Metaphyseal sleeves in total knee arthroplasty revision: complications, clinical
      and radiological results. A systematic review of the literature.
AB  - INTRODUCTION: Total knee arthroplasty revision (TKAr) is increasing of relevance
      in orthopaedic surgeon daily practice and will become more and more relevant in
      the future. The aim of this study is to summarize indications, complications,
      clinical and radiological mid-term results of metaphyseal sleeves in management
      of bone defects in TKAr. METHODS: A systematic review of English literature was
      performed on Medline. Retrospective or prospective studies with 2 years of follow
      up (FU) were included. The PRISMA 2009 flowchart and checklist were considered to
      edit the review. Rates of intraoperative fractures, aseptic loosening,
      periprosthetic joint infection (PJI), reoperations and re-revisions were
      extrapolated by the papers. RESULTS: 13 articles with a level of evidence of IV
      were included in the systematic review. 1079 TKAr (1554 sleeves) with a mean FU
      of 4.0 +/- 1.1 years were analysed. The studies showed good clinical and
      functional outcomes. Sleeves allowed a stable metaphyseal fixation and
      osseointegration with an implant and sleeves aseptic survival rate of 97.7 and
      99.2%, respectively. The incidence of PJI was 2.7 +/- 2.4%. The estimated rate of
      reoperations and re-revisions were 14.2 +/- 9.2 and 7.1 +/- 4.8%, respectively.
      CONCLUSION: Metaphyseal sleeves represent a viable option in management of types
      IIb and III AORI bone defects in TKAr. Further high-quality log-term studies
      would better clarify complications, clinical and radiological results of this
      promising technique in total knee arthroplasty revision.

PMID- 29845318
TI  - egl-4 modulates electroconvulsive seizure duration in C. elegans.
AB  - Increased neuronal excitability causes seizures with debilitating symptoms.
      Effective and noninvasive treatments are limited for easing symptoms, partially
      due to the complexity of the disorder and lack of knowledge of specific molecular
      faults. An unexplored, novel target for seizure therapeutics is the cGMP/protein
      kinase G (PKG) pathway, which targets downstream K+ channels, a mechanism similar
      to Retigabine, a recently FDA-approved antiepileptic drug. Our results
      demonstrate that increased PKG activity decreased seizure duration in C. elegans
      utilizing a recently developed electroconvulsive seizure assay. While the fly is
      a well-established seizure model, C. elegans are an ideal yet unexploited model
      which easily uptakes drugs and can be utilized for high-throughput screens. In
      this study, we show that treating the worms with either a potassium channel
      opener, Retigabine or published pharmaceuticals that increase PKG activity,
      significantly reduces seizure recovery times. Our results suggest that PKG
      signaling modulates downstream K+ channel conductance to control seizure recovery
      time in C. elegans. Hence, we provide powerful evidence, suggesting that
      pharmacological manipulation of the PKG signaling cascade may control seizure
      duration across phyla.

PMID- 29845319
TI  - Advanced non-contrasted computed tomography post-processing by CT-Calculometry
      (CT-CM) outperforms established predictors for the outcome of shock wave
      lithotripsy.
AB  - OBJECTIVES: To evaluate the predictive value of advanced non-contrasted computed
      tomography (NCCT) post-processing using novel CT-calculometry (CT-CM) parameters
      compared to established predictors of success of shock wave lithotripsy (SWL) for
      urinary calculi. MATERIALS AND METHODS: NCCT post-processing was retrospectively
      performed in 312 patients suffering from upper tract urinary calculi who were
      treated by SWL. Established predictors such as skin to stone distance, body mass
      index, stone diameter or mean stone attenuation values were assessed. Precise
      stone size and shape metrics, 3-D greyscale measurements and homogeneity
      parameters such as skewness and kurtosis, were analysed using CT-CM. Predictive
      values for SWL outcome were analysed using logistic regression and receiver
      operating characteristics (ROC) statistics. RESULTS: Overall success rate (stone
      disintegration and no re-intervention needed) of SWL was 59% (184 patients). CT
      CM metrics mainly outperformed established predictors. According to ROC analyses,
      stone volume and surface area performed better than established stone diameter,
      mean 3D attenuation value was a stronger predictor than established mean
      attenuation value, and parameters skewness and kurtosis performed better than
      recently emerged variation coefficient of stone density. Moreover, prediction of
      SWL outcome with 80% probability to be correct would be possible in a clearly
      higher number of patients (up to fivefold) using CT-CM-derived parameters.
      CONCLUSIONS: Advanced NCCT post-processing by CT-CM provides novel parameters
      that seem to outperform established predictors of SWL response. Implementation of
      these parameters into clinical routine might reduce SWL failure rates.

PMID- 29845320
TI  - Surveillance and management of urologic complications after spinal cord injury.
AB  - PURPOSE: Neurogenic bladder due to spinal cord injury has significant
      consequences for patients' health and quality of life. Regular surveillance is
      required to assess the status of the upper and lower urinary lower urinary tracts
      and prevent their deterioration. In this review, we examine surveillance
      techniques in neurogenic bladder, describe common complications of this disease,
      and address strategies for their management. METHODS: This work represents the
      efforts of SIU-ICUD joint consultation on Urologic Management of the Spinal Cord
      injury. For this specific topic, a workgroup was formed and comprehensive
      literature search of English language manuscripts regarding neurogenic bladder
      management was performed using key words of neurogenic bladder. Articles were
      compiled, and recommendations in the chapter are based on group discussion and
      follow the Oxford Centre for Evidence-based Medicine system for Levels of
      Evidence (LOEs) and Grades of Recommendation (GORs). RESULTS: At a minimum,
      patients should undergo an annual history and physical examination, renal
      functional testing (e.g., serum creatinine), and upper tract imaging (e.g., renal
      ultrasonography). The existing evidence does not support the use of other
      modalities, such as cystoscopy or urodynamics, for routine surveillance. Urologic
      complications in neurogenic bladder patients are common and often more complex
      than in the general population. CONCLUSIONS: There is a shortage of high-quality
      evidence to support any particular neurogenic bladder surveillance protocol.
      However, there is consensus regarding certain aspects of regular genitourinary
      system evaluation in these patients. Proper surveillance allows the clinician to
      avoid or address common urological complications, and to guide, alter, or
      maintain appropriate therapeutic regimens for individual patients.

PMID- 29845323
TI  - Separation of hydrophobically modified hyaluronic acid according to the degree of
      substitution by gradient elution high performance liquid chromatography.
AB  - Amphiphilic hyaluronic acid (HA), synthesised by modifying HA to varying extents
      with acrylate groups, was successfully separated according to degree of
      substitution (DS) using solvent gradient high performance liquid chromatography
      (HPLC). Two HPLC methods based on the amphiphilic structure of the HA were
      developed. In the first approach, normal phase gradient HPLC was explored, and
      separation was based on the interactions of HA's polar hydroxyl groups with a
      polar cyano stationary phase. In the second approach, separation was based on the
      interaction of the hydrophobic acrylate moieties with a non-polar C8 stationary
      phase (reversed phase gradient HPLC). The separation was optimised by using an
      electrolyte in the sample solvent to suppress non-covalent interactions and
      improve the selectivity of the developed method. The photolytic stability of the
      modified and unmodified HA was also investigated in order to optimise the sample
      preparation procedure. Furthermore, an alternative method to NMR spectroscopy was
      developed for determining the DS of HA. Graphical abstract ?.

PMID- 29845321
TI  - Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical
      Management.
AB  - PURPOSE OF REVIEW: Pediatric chronic rhinosinusitis (CRS) is a common disorder
      that carries significant morbidity. The diagnosis requires sinus symptoms that
      persist despite standard medical therapy greater than 3 months. Viral infections,
      allergies, and anatomic differences in children lead to chronic obstruction of
      the osteomeatal complex. RECENT FINDINGS: Chronic rhinosinusitis as a diagnosis
      is a conglomeration of multiple phenotypes and endotypes. As such, the diagnosis
      and management are complex. New survey studies provide some consensus on
      prevalence and management of this disease in children. In this review, we
      highlight the differential diagnosis of pediatric CRS, including non
      eosinophilic/infectious variants, eosinophilic variants with and without nasal
      polyps, allergic fungal sinusitis, aspirin-exacerbated respiratory disease,
      primary immunodeficiency, and disorders of mucociliary clearance. Further, we
      detail treatment options that should be considered. Finally, we feature emerging
      potential treatment options of CRS, including anti-immunoglobulin E, interleukin
      5, and interleukin-4 receptor alpha subunit.

PMID- 29845325
TI  - Vitamin D deficiency and depressive symptoms in the perinatal period.
AB  - Depression affects 1 in 7 women during the perinatal period. Women with vitamin D
      deficiency may be at an increased risk for depression. This study investigated
      the relationship between maternal and cord blood 25-hydroxyvitamin D (25OHD) and
      maternal depressive symptoms over the perinatal period. Study objectives were to
      examine variations and relationships between maternal and cord blood vitamin D
      levels and maternal depressive symptoms over the perinatal period. At a large
      medical center in southern California, pregnant women (N = 126) were recruited
      for this longitudinal cohort study. Depressive symptoms (Edinburgh Postnatal
      Depression Screen, EPDS) and vitamin D status (25OHD) were measured at three time
      points in the perinatal period: time 1 (T1; N = 125) EPDS and 25OHD were
      collected in early pregnancy; time 2 (T2; N = 96) EPDS was conducted in the third
      trimester with blood collected at time of delivery; and time 3 (T3; N = 88) was
      collected postpartum. A significant inverse relationship between vitamin D status
      and depressive symptoms was observed between 25OHD and EPDS scores at all time
      points in this sample (T1 = - 0.18, P = 0.024; T2 = - 0.27, P = 0.009; T3 = -
      0.22, P = 0.019). This association remained after controlling for confounders.
      Low cord blood 25OHD levels were inversely associated with higher EPDS scores in
      the third trimester (r = - 0.22, P = 0.02). Clinicians may want to consider
      screening women diagnosed with vitamin D deficiency for depression and vice
      versa. Vitamin D may represent an important biomarker for pregnant and postpartum
      women diagnosed with depression. Further studies examining underlying mechanisms
      and supplementation are needed.

PMID- 29845324
TI  - Analysis of lipid adsorption on nanoparticles by nanoflow liquid chromatography
      tandem mass spectrometry.
AB  - Nanoparticles (NPs) tend to adsorb matrix molecules like proteins and lipids
      incubated with biological fluids, forming a biological corona. While the
      formation and functions of protein corona have been studied extensively, little
      attention has been paid to lipid adsorption on NPs. However, lipids are also
      abundantly present in biological fluids and play important roles in processes
      like cell signaling and angiogenesis. Therefore, in this study, we established
      the analytical procedure for study of lipid adsorption on three different types
      of NPs in two matrices: human serum and heavy cream, using nanoflow liquid
      chromatography-mass spectrometry (nanoflowLC-MS). Serum was chosen to represent
      the common environment the NPs would be present once entering human body, and
      heavy cream was the representative food matrix NPs may be added to improve the
      color or taste. Steps of liquid-liquid extraction were established and optimized
      to achieve maximum recovery of the adsorbed, standard lipids from the NPs. Then,
      the LC-MS/MS method was developed to attain base-line separation of the standard
      lipids that represent the major lipid classes. At last, the lipid adsorption
      profiles of the three NPs were compared. We found that the lipid adsorption
      profile on the same type of NP was significantly different between the two
      matrices. The established method will help us investigate lipid adsorption on
      additional NPs and reveal how it could be affected by the physiochemical
      properties of NPs and the presence of proteins and other components in the
      biological matrix.

PMID- 29845326
TI  - Functional outcome of acute primary total hip replacement after complex
      acetabular fractures.
AB  - PURPOSE: To assess the functional outcome of acute primary total hip replacement
      in the management of complex acetabular fractures. MATERIALS AND METHODS: This
      prospective observational study was conducted in orthopedic department of Liaquat
      National Hospital and Medical College, Karachi. The study was approved by the
      Ethics review committee of hospital (0190-2016). Patients who encountered between
      January 2010 to January 2016 were entered. Fifty-four patients with acetabular
      fractures with certain indications (marginal impaction or significant comminution
      (> 3 fragments) of the articular surface of the acetabulum, full-thickness
      articular injury to the femoral head, an associated femur neck fracture, or
      preexisting symptomatic osteoarthritis) were treated with primary total hip
      replacement. Patients were followed in outpatient clinic at regular intervals
      after discharge to assess the radiological union of fractures and complications.
      Functional outcome was evaluated after 2 years by applying Harris Hip Score. All
      statistical analysis was done by using SPSS version 20. RESULTS: All patients
      achieved radiological union of fractures at an average duration of 21 weeks.
      During the follow-up, seven complications were observed. Two patients developed
      superficial surgical site infection which was treated conservatively. One patient
      had dislocation which was reduced closely, while two patients had acetabular cup
      loosening which was revised. We also observed two cases of Brooker I heterotopic
      ossification and one case of Brooker II. At 2-year follow-up, 78% of patients had
      an excellent and good functional outcome according to Harris Hip score.
      CONCLUSION: Primary total hip replacement is a valid and reasonable one stage
      surgical treatment of complex acetabular fractures and in aged individuals.
      However, the complications are not uncommon.

PMID- 29845327
TI  - Comparative outcomes of epidural steroids versus placebo after lumbar discectomy
      in lumbar disc herniation: a systematic review and meta-analysis of randomized
      controlled trials.
AB  - Treatment for lumbar disc herniation after failed conservative treatment is
      discectomy. Discectomy can significantly relieve back pain as well as radicular
      symptoms. However, many patients with lumbar discectomy experience moderate-to
      severe back pain and radicular leg pain. The results of application of epidural
      steroids (ES) for pain management after lumbar discectomy have previously been
      inconclusive. We have conducted a systematic review and meta-analysis aims to
      compare outcomes (efficacy and complications) of epidural steroid application and
      placebo after discectomy in lumbar disc herniation. This systematic review was
      conducted according to the Preferred Reporting Items for Systematic Reviews and
      Meta-Analyses guidelines. Relevant studies that reported visual analog scale of
      back and leg pain, morphine consumption, hospital stay and post-operative
      complications of either group were identified from Medline and Scopus from the
      date of inception to 28 October 2017. A total of 12 studies were pooled and
      analysed, with nine studies having undergone conventional discectomy and three
      studies having undergone minimally invasive surgery (MIS) discectomy. Overall,
      there were 1006 patients (502 in the ES group and 504 in the placebo group)
      included. The unstandardized mean difference of VAS of back pain at 1 week and 1
      month, leg pain at 1 week and 1 month, morphine consumption and hospital stay was
      - 0.53 (95% CI - 1.42, 0.36) score, - 0.89 (95% CI - 1.36, - 0.42) score, - 0.63
      (95% CI - 0.75, - 0.50) score, - 0.47 (95% CI - 0.78, - 0.15) score, - 8.47 (95%
      CI - 16.16, - 0.78) mg and - 0.89 (95% CI - 1.49, - 0.30) days lower when
      compared to placebo after lumbar discectomy in patients with lumbar disc
      herniation. A total of ten studies compared the ratio of complication between the
      ES and placebo groups. No significant differences were noted for complications
      within the two groups (0.92; 95% CI 0.47, 1.83). This meta-analysis analysed
      lower back and leg pain, morphine consumption and hospital stay, with no
      significant difference in complications for ES application after lumbar
      discectomy in lumbar disc herniation. In terms of surgical approaches with MIS
      compared to conventional approach, this review demonstrates that ES can reduce
      post-operative morphine consumption when the surgical approach is conventional,
      but not for MIS.Level of evidence I.

PMID- 29845328
TI  - Comparison of Duke Activity Status Index with cardiopulmonary exercise testing in
      cancer patients.
AB  - PURPOSE: The Duke Activity Status Index (DASI), a patient-administered
      questionnaire, is used to quantify functional capacity in patients undergoing
      cancer surgery. METHODS: This retrospective cohort study assessed whether the
      DASI was accurate in predicting peak oxygen consumption (pVO2) that was
      objectively measured using cardiopulmonary exercise testing (CPET) in 43
      consecutive patients scheduled for elective major cancer surgery at a tertiary
      cancer centre. The primary outcome measured the limits of agreement between DASI
      predicted pVO2 and actual measured pVO2. RESULTS: The study population was
      elderly (median 63 years, interquartile range 18), 58% were male, with the
      majority having intraabdominal cancer surgery. Although the DASI scores were
      statistically related to the measured pVO2 (N = 43, adjusted R2 = 0.20, p =
      0.002), both the bias (8 ml kg- 1 min- 1) and 95% limits of agreement (19.5 to -
      3.4 ml kg- 1 min- 1) between the predicted and measured pVO2 were large. Using
      some of the individual components, recalibrating the intercept and regression
      coefficient of the total DASI score did not substantially improve its ability to
      predict the measured pVO2. CONCLUSION: In summary, both the limits of agreement
      and bias between the measured and DASI-predicted pVO2 were substantial. The DASI
      predicted pVO2 based on patient's assessment of their functional status could not
      be considered a reliable surrogate of measured pVO2 during CPET for the
      population of patients pending major cancer surgery and cannot, therefore, be
      used as a triage tool for referral to CPET centres for objective risk assessment.

PMID- 29845329
TI  - A Prediction Model of Tumor Progression and Survival in HER2-Positive Metastatic
      Gastric Cancer Patients Treated with Trastuzumab and Chemotherapy.
AB  - The effects of different patient factors and dose levels of chemotherapeutic
      agents on clinical outcomes in advanced gastric cancer are not as yet fully
      characterized. We aimed at developing an integrative model that incorporates dose
      and covariate information to predict tumor growth and patient survival in
      advanced gastric cancer patients treated with trastuzumab (T), 5
      FU(F)/capecitabine (X) (F or X), and cisplatin (P). Sixty-nine patients (training
      dataset) were used for model building and a separate 86 patients (test dataset)
      for model validation. A fraction of tumor cells sensitive to each drug was
      incorporated as a model parameter, and T was assumed as cytostatic and X/F and P
      as cytotoxic. Cox proportional hazards analyses were performed on model
      parameters and patient covariates. The model well described the time course of
      observed tumor size changes, and revealed that the pretreatment tumor growth rate
      constant k g , which was formulated as a function of pretreatment disease
      duration and baseline tumor size, was positively correlated with baseline tumor
      size (p = 0.0084) and histologic grade (p = 0.034), and the efficacy of 5-FU with
      body weight (p < 2e-16) and that of cisplatin with histologic grade (p =
      0.00013). Prior gastrectomy and Eastern Cooperative Oncology Group scores were
      significant prognostic factors for progression-free survival (PFS). For hazards
      analysis, a unit increase of k g was associated with a relative risk of 3.19 for
      PFS (p = 0.00055) and 4.45 for OS (p = 2e-04) in the test dataset, with a similar
      trend observed in the training dataset. Dose-response simulations showed that,
      for small baseline tumor size or low histologic grade, a maximum cytotoxic effect
      was attainable with a dose smaller than the current recommended dose.

PMID- 29845330
TI  - Changes in arterial pressure hemodynamics in response to renal nerve stimulation
      both before and after renal denervation.
AB  - BACKGROUND: Renal nerve denervation (RDN) is developed as a potential treatment
      for hypertension. Recently, we reported the use of renal nerve stimulation (RNS)
      to localize sympathetic nerve tissue for subsequent selective RDN. The effects of
      RNS on arterial pressure dynamics remain unknown. The current study aimed to
      describe the acute changes in arterial pressure dynamics response to RNS before
      and after RDN. METHODS AND RESULTS: Twenty six patients with drug-resistant
      hypertension referred for RDN were included. RNS was performed under general
      anesthesia before and after RDN. We continuously monitored heart rate (HR) and
      invasive femoral blood pressure (BP). Augmentation pressure (AP) and index (Aix),
      pulse pressure (PP), time to reflected wave, maximum systolic BP and dicrotic
      notch were calculated. Systolic and diastolic BP at site of maximum response
      significantly increased in response to RNS (120 +/- 16/62 +/- 9 to 150 +/- 22/75
      +/- 15 mmHg) (p < 0.001/< 0.001), whereas after RDN no RNS-induced BP change was
      observed (p > 0.10). RNS increased Aix (29 +/- 11 to 32 +/- 13%, p = 0.005), PP
      (59 +/- 14 to 75 +/- 17 mmHg, p < 0.001), time to reflected wave (63 +/- 18 to 71
      +/- 25 ms, p = 0.004) and time to maximum systolic pressure (167 +/- 36 to 181 +/
      46 ms, p = 0.004) before RDN, whereas no changes were observed after RDN (p >
      0.18). All changes were BP dependent. RNS had no influence on HR or the time to
      dicrotic notch (p > 0.12).   CONCLUSION: RNS induces temporary rises in Aix, PP,
      time to maximum systolic pressure and time to reflected wave. These changes are
      BP dependent and were completely blunted after RDN.

PMID- 29845331
TI  - Sleep-disordered breathing in patients with cardiovascular diseases cannot be
      detected by ESS, STOP-BANG, and Berlin questionnaires.
AB  - Sleep-disordered breathing (SDB) is highly prevalent in patients with
      cardiovascular diseases (CVD) and associated with poor outcome. At least 50% of
      heart failure (HF) patients present with SDB, equally divided in obstructive
      sleep apnea (OSA) and central sleep apnea (CSA). CVD patients with SDB do not
      always present with typical SDB symptoms. Therefore, we asked whether established
      questionnaires allow for the reliable detection of SDB. In this prospective
      cohort study, 89 CVD patients (54 male, 59 +/- 15 years, BMI 30 +/- 6 kg/m2) in
      stable clinical state underwent an ambulatory polygraphy. SDB was defined as an
      apnea-hypopnea index (AHI) >= 15/h. We evaluated the Epworth Sleepiness Scale
      (ESS), STOP-BANG and Berlin questionnaires as well as anthropometric data and
      comorbidities regarding their ability to predict SDB. The ESS showed no
      correlation with SDB. The sensitivity of the Berlin Questionnaire to detect SDB
      was 73%, specificity was 42%. The STOP-BANG questionnaire showed a sensitivity of
      97% while specificity was 13%. Coronary heart disease and/or history of
      myocardial infarction, hyperuricemia and age significantly contributed to a
      logistic regression model predicting presence of SDB. However, our regression
      model explains only 36% of the variance regarding the presence or absence of SDB.
      The approach to find variables, which would allow an early and reliable
      differentiation between patients with CVD and coexistence or absence of SDB,
      failed. Thus, as CVD patients show a high SDB prevalence and poor outcome, only a
      systematic screening based on measures of respiration-related parameters (i.e.,
      respiratory flow, blood oxygen saturation, etc.) allows for a reliable SDB
      assessment.

PMID- 29845332
TI  - [Chiari malformation].
AB  - Chiari malformation is one of the most common congenital anomalies involving both
      skeletal and neuronal structures. Magnetic Resonance Imaging(MRI) is nowadays
      considered the imaging technique of choice for the diagnosis of Chiari
      malformations. Computed Tomography (CT) scans may provide additional information
      about skeletal anomalies.

PMID- 29845333
TI  - A selective CD28 antagonist and rapamycin synergise to protect against
      spontaneous autoimmune diabetes in NOD mice.
AB  - AIMS/HYPOTHESIS: The CD28/B7 interaction is critical for both effector T cell
      activation and forkhead box P3 (FOXP3)+ regulatory T cell (Treg) generation and
      homeostasis, which complicates the therapeutic use of cytotoxic T lymphocyte
      associated antigen 4 (CTLA-4)-immunoglobulin fusion protein (CTLA-4Ig) in
      autoimmunity. Here, we evaluated the impact of a simultaneous and selective
      blockade of the CD28 and mammalian target of rapamycin (mTOR) pathways in the NOD
      mouse model of type 1 diabetes. METHODS: NOD mice were treated with PEGylated
      anti-CD28 Fab' antibody fragments (PV1-polyethylene glycol [PEG], 10 mg/kg i.p.,
      twice weekly), rapamycin (1 mg/kg i.p., twice weekly) or a combination of both
      drugs. Diabetes incidence, pancreatic islet infiltration and autoreactive T cell
      responses were analysed. RESULTS: We report that 4 week administration of PV1-PEG
      combined with rapamycin effectively controlled the progression of autoimmune
      diabetes in NOD mice at 10 weeks of age by reducing T cell activation and
      migration into the pancreas. Treatment with rapamycin alone was without effect,
      as was PV1-PEG monotherapy initiated at 4, 6 or 10 weeks of age. Prolonged PV1
      PEG administration (for 10 weeks) accelerated diabetes development associated
      with impaired peripheral Treg homeostasis. This effect was not observed with the
      combined treatment. CONCLUSIONS/INTERPRETATION: CD28 antagonist and rapamycin
      treatment act in a complementary manner to limit T cell activation and
      infiltration of pancreatic islets and diabetes development. These data provide
      new perspectives for the treatment of autoimmune diabetes and support the
      therapeutic potential of protocols combining antagonists of CD28 (presently in
      clinical development) and the mTOR pathway.

PMID- 29845334
TI  - Enhancement of a-IGZO TFT Device Performance Using a Clean Interface Process via
      Etch-Stopper Nano-layers.
AB  - To overcome the technological and economic obstacles of amorphous indium-gallium
      zinc-oxide (a-IGZO)-based display backplane for industrial production, a clean
      etch-stopper (CL-ES) process is developed to fabricate a-IGZO-based thin film
      transistor (TFT) with improved uniformity and reproducibility on 8.5th generation
      glass substrates (2200 mm * 2500 mm). Compared with a-IGZO-based TFT with back
      channel-etched (BCE) structure, a newly formed ES nano-layer (~ 100 nm) and a
      simultaneous etching of a-IGZO nano-layer (30 nm) and source-drain electrode
      layer are firstly introduced to a-IGZO-based TFT device with CL-ES structure to
      improve the uniformity and stability of device for large-area display. The
      saturation electron mobility of 8.05 cm2/V s and the Vth uniformity of 0.72 V are
      realized on the a-IGZO-based TFT device with CL-ES structure. In the negative
      bias temperature illumination stress and positive bias thermal stress reliability
      testing under a +/- 30 V bias for 3600 s, the measured Vth shift of CL-ES
      structured device significantly decreased to - 0.51 and + 1.94 V, which are much
      lower than that of BCE-structured device (- 3.88 V, + 5.58 V). The electrical
      performance of the a-IGZO-based TFT device with CL-ES structure implies that the
      economic transfer from a silicon-based TFT process to the metal oxide
      semiconductor-based process for LCD fabrication is highly feasible.

PMID- 29845335
TI  - "I am spiritual, but not religious": Does one without the other protect against
      adolescent health-risk behaviour?
AB  - OBJECTIVES: Spirituality and religious attendance (RA) have been suggested to
      protect against adolescent health-risk behaviour (HRB). The aim of this study was
      to explore the interrelatedness of these two concepts in a secular environment.
      METHODS: A nationally representative sample (n = 4566, 14.4 +/- 1.1 years, 48.8%
      boys) of adolescents participated in the 2014 Health Behaviour in School-aged
      Children cross-sectional study. RA, spirituality (modified version of the
      Spiritual Well-Being Scale), tobacco, alcohol, cannabis and drug use and the
      prevalence of sexual intercourse were measured. RESULTS: RA and spirituality were
      associated with a lower chance of weekly smoking, with odds ratios (OR) 0.57 [95%
      confidence interval (CI) 0.36-0.88] for RA and 0.88 (0.80-0.97) for spirituality.
      Higher spirituality was also associated with a lower risk of weekly drinking [OR
      (95% CI) 0.91 (0.83-0.995)]. The multiplicative interaction of RA and
      spirituality was associated with less risky behaviour for four of five explored
      HRB. RA was not a significant mediator for the association of spirituality with
      HRB. CONCLUSIONS: Our findings suggest that high spirituality only protects
      adolescents from HRB if combined with RA.

PMID- 29845336
TI  - Association Between the Methicillin Resistance of Staphylococcus aureus Isolated
      from Slaughter Poultry, Their Toxin Gene Profiles and Prophage Patterns.
AB  - In this work, 85 strains of Staphylococcus aureus were isolated from samples
      taken from slaughter poultry in Poland. Attempts were made to determine the
      prophage profile of the strains and to investigate the presence in their genome
      of genes responsible for the production of five classical enterotoxins (A-E),
      toxic shock syndrome toxin (TSST-1), exfoliative toxins (ETA and ETB) and
      staphylokinase (SAK). For this purpose, multiplex PCR was performed using primer
      specific pairs for targeted genes. The presence of the mecA gene was found in 26
      strains (30.6%). The genomes of one of the methicillin-resistant S. aureus (MRSA)
      strains and two methicillin-sensitive S. aureus (MSSA) strains contained the gene
      responsible for the production of enterotoxin A. Only one MRSA strain and two
      MSSA strains showed the presence of the toxic shock syndrome toxin (tst) gene.
      Only one of the MSSA strains had the gene (eta) responsible for the production of
      exfoliative toxins A. The presence of the staphylokinase gene (sak) was confirmed
      in 13 MRSA strains and in 5 MSSA strains. The study results indicated a high
      prevalence of prophages among the test isolates of Staphylococcus aureus. In all,
      15 prophage patterns were observed among the isolates. The presence of 77-like
      prophages incorporated into bacterial genome was especially often demonstrated.
      Various authors emphasize the special role of these prophages in the spread of
      virulence factors (staphylokinase, enterotoxin A) not only within strains of the
      same species but also between species and even types of bacteria.

PMID- 29845337
TI  - Subjective and objective comparisons of image quality between ultra-high
      resolution CT and conventional area detector CT in phantoms and cadaveric human
      lungs.
AB  - OBJECTIVES: To compare the image quality of the lungs between ultra-high
      resolution CT (U-HRCT) and conventional area detector CT (AD-CT) images. METHODS:
      Image data of slit phantoms (0.35, 0.30, and 0.15 mm) and 11 cadaveric human
      lungs were acquired by both U-HRCT and AD-CT devices. U-HRCT images were obtained
      with three acquisition modes: normal mode (U-HRCTN: 896 channels, 0.5 mm * 80
      rows; 512 matrix), super-high-resolution mode (U-HRCTSHR: 1792 channels, 0.25 mm
      * 160 rows; 1024 matrix), and volume mode (U-HRCTSHR-VOL: non-helical acquisition
      with U-HRCTSHR). AD-CT images were obtained with the same conditions as U-HRCTN.
      Three independent observers scored normal anatomical structures (vessels and
      bronchi), abnormal CT findings (faint nodules, solid nodules, ground-glass
      opacity, consolidation, emphysema, interlobular septal thickening, intralobular
      reticular opacities, bronchovascular bundle thickening, bronchiectasis, and
      honeycombing), noise, artifacts, and overall image quality on a 3-point scale (1
      = worst, 2 = equal, 3 = best) compared with U-HRCTN. Noise values were calculated
      quantitatively. RESULTS: U-HRCT could depict a 0.15-mm slit. Both U-HRCTSHR and U
      HRCTSHR-VOL significantly improved visualization of normal anatomical structures
      and abnormal CT findings, except for intralobular reticular opacities and reduced
      artifacts, compared with AD-CT (p < 0.014). Visually, U-HRCTSHR-VOL has less
      noise than U-HRCTSHR and AD-CT (p < 0.00001). Quantitative noise values were
      significantly higher in the following order: U-HRCTSHR (mean, 30.41), U-HRCTSHR
      VOL (26.84), AD-CT (16.03), and U-HRCTN (15.14) (p < 0.0001). U-HRCTSHR and U
      HRCTSHR-VOL resulted in significantly higher overall image quality than AD-CT and
      were almost equal to U-HRCTN (p < 0.0001). CONCLUSIONS: Both U-HRCTSHR and U
      HRCTSHR-VOL can provide higher image quality than AD-CT, while U-HRCTSHR-VOL was
      less noisy than U-HRCTSHR. KEY POINTS: * Ultra-high-resolution CT (U-HRCT) can
      improve spatial resolution. * U-HRCT can reduce streak and dark band artifacts. *
      U-HRCT can provide higher image quality than conventional area detector CT. * In
      U-HRCT, the volume mode is less noisy than the super-high-resolution mode. * U
      HRCT may provide more detailed information about the lung anatomy and pathology.

PMID- 29845338
TI  - Establishment of adoptive cell therapy with tumor infiltrating lymphocytes for
      non-small cell lung cancer patients.
AB  - Adoptive cell therapy (ACT) of tumor infiltration lymphocytes (TIL) yields
      promising clinical results in metastatic melanoma patients, who failed standard
      treatments. Due to the fact that metastatic lung cancer has proven to be
      susceptible to immunotherapy and possesses a high mutation burden, which makes it
      responsive to T cell attack, we explored the feasibility of TIL ACT in non-small
      cell lung cancer (NSCLC) patients. Multiple TIL cultures were isolated from tumor
      specimens of five NSCLC patients undergoing thoracic surgery. We were able to
      successfully establish TIL cultures by various methods from all patients within
      an average of 14 days. Fifteen lung TIL cultures were further expanded to
      treatment levels under good manufacturing practice conditions and functionally
      and phenotypically characterized. Lung TIL expanded equally well as 103 melanoma
      TIL obtained from melanoma patients previously treated at our center, and had a
      similar phenotype regarding PD1, CD28, and 4-1BB expressions, but contained a
      higher percent of CD4 T cells. Lung carcinoma cell lines were established from
      three patients of which two possessed TIL cultures with specific in vitro anti
      tumor reactivity. Here, we report the successful pre-clinical production of TIL
      for immunotherapy in the lung cancer setting, which may provide a new treatment
      modality for patients with metastatic NSCLC. The initiation of a clinical trial
      is planned for the near future.

PMID- 29845339
TI  - Hybrid 99mTc-magnetite tracer for dual modality sentinel lymph node mapping.
AB  - Accuracy of sentinel lymph node identification using radioactive tracers in non
      superficial cancers can be limited by radiation shine through and low spatial
      resolution of detection systems such as intraoperative gamma probes. By utilising
      a dual radioactive/magnetic tracer, sensitive lymphoscintigraphy can be paired
      with high spatial resolution intraoperative magnetometer probes to improve the
      accuracy of sentinel node detection in cancers with complex multidirectional
      lymphatic drainage. Dextran-coated magnetite nanoparticles (33 nm mean
      hydrodynamic diameter) were labelled with 99mTc and applied as a lymphotropic
      tracer in small and large animal models. The dual tracer could be radiolabelled
      with 98 +/- 2% efficiency after 10 min of incubation at room temperature.
      Biodistribution studies of the tracer were conducted in normal rats (subdermal
      and intravenous tail delivery, n = 3) and swine (subdermal hind limb delivery, n
      = 5). In rats the dual tracer migrated through four tiers of lymph node, 20 min
      after subdermal injection. Results from intravenous biodistribution test for
      radiocolloids demonstrated no aggregation in vivo, however indicated the presence
      of some lower-molecular weight radioactive impurities (99mTc-dextran). In swine,
      the dual tracer could be effectively used to map lymphatic drainage from hind
      hoof to popliteal and inguinal basins using intraoperative gamma and magnetometer
      probes. Of the eight primary nodes excised, eight were positively identified by
      gamma probe and seven by magnetometer probe. The high-purity dual tracer shows
      early promise for sentinel node identification in complex lymphatic environments
      by combining sensitive preoperative lymphoscintigraphy with a high-resolution
      intraoperative magnetometer probe.

PMID- 29845341
TI  - EBUS-TBNA is Sufficient for Successful Diagnosis of Silicosis with Mediastinal
      Lymphadenopathy.
AB  - BACKGROUND: Silicosis is an occupational lung disease resulting from inhalation
      of respirable crystalline silica. Recently, an international silicosis epidemic
      has been noted among artificial stone workers. OBJECTIVE: Endobronchial
      ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is currently used
      for patients with unexplained lymphadenopathy. Since silicosis may present with
      prominent lymphadenopathy, the diagnostic yield of EBUS-TBNA in diagnosing
      silicosis was evaluated. METHODS: Twenty-eight patients with suspected silicosis
      referred for outpatient evaluation in three large tertiary hospitals were
      evaluated. Patients with mediastinal lymphadenopathy underwent EBUS-TBNA, while
      others underwent TBB and/or video-assisted thoracoscopic surgery (VATS). RESULTS:
      Eleven patients with mediastinal lymphadenopathy (39%) were evaluated using EBUS
      TBNA. The diagnosis was accurate in all cases, demonstrating silica particles
      under polarized light, with no complications. Among the remaining patients, TBB
      was only 76% diagnostic, therefore requiring VATS. CONCLUSIONS: EBUS-TBNA is a
      useful and sufficient tool to diagnose silicosis in patients with mediastinal
      lymphadenopathy along compatible exposure histories.

PMID- 29845342
TI  - Triple Issues Underlying Lung Injury for Adolescent Idiopathic Scoliosis Surgery.

PMID- 29845340
TI  - Childhood aggression and the co-occurrence of behavioural and emotional problems:
      results across ages 3-16 years from multiple raters in six cohorts in the EU
      ACTION project.
AB  - Childhood aggression and its resulting consequences inflict a huge burden on
      affected children, their relatives, teachers, peers and society as a whole.
      Aggression during childhood rarely occurs in isolation and is correlated with
      other symptoms of childhood psychopathology. In this paper, we aim to describe
      and improve the understanding of the co-occurrence of aggression with other forms
      of childhood psychopathology. We focus on the co-occurrence of aggression and
      other childhood behavioural and emotional problems, including other externalising
      problems, attention problems and anxiety-depression. The data were brought
      together within the EU-ACTION (Aggression in Children: unravelling gene
      environment interplay to inform Treatment and InterventiON strategies) project.
      We analysed the co-occurrence of aggression and other childhood behavioural and
      emotional problems as a function of the child's age (ages 3 through 16 years),
      gender, the person rating the behaviour (father, mother or self) and assessment
      instrument. The data came from six large population-based European cohort studies
      from the Netherlands (2x), the UK, Finland and Sweden (2x). Multiple assessment
      instruments, including the Child Behaviour Checklist (CBCL), the Strengths and
      Difficulties Questionnaire (SDQ) and Multidimensional Peer Nomination Inventory
      (MPNI), were used. There was a good representation of boys and girls in each age
      category, with data for 30,523 3- to 4-year-olds (49.5% boys), 20,958 5- to 6
      year-olds (49.6% boys), 18,291 7- to 8-year-olds (49.0% boys), 27,218 9- to 10
      year-olds (49.4% boys), 18,543 12- to 13-year-olds (48.9% boys) and 10,088 15- to
      16-year-olds (46.6% boys). We replicated the well-established gender differences
      in average aggression scores at most ages for parental ratings. The gender
      differences decreased with age and were not present for self-reports. Aggression
      co-occurred with the majority of other behavioural and social problems, from both
      externalising and internalising domains. At each age, the co-occurrence was
      particularly prevalent for aggression and oppositional and ADHD-related problems,
      with correlations of around 0.5 in general. Aggression also showed substantial
      associations with anxiety-depression and other internalizing symptoms
      (correlations around 0.4). Co-occurrence for self-reported problems was somewhat
      higher than for parental reports, but we found neither rater differences, nor
      differences across assessment instruments in co-occurrence patterns. There were
      large similarities in co-occurrence patterns across the different European
      countries. Finally, co-occurrence was generally stable across age and sex, and if
      any change was observed, it indicated stronger correlations when children grew
      older. We present an online tool to visualise these associations as a function of
      rater, gender, instrument and cohort. In addition, we present a description of
      the full EU-ACTION projects, its first results and the future perspectives.

PMID- 29845343
TI  - The effects of extra PCR cycles when amplifying skeletal samples with the
      GlobalFiler(r) PCR Amplification Kit.
AB  - When samples with low amounts of DNA are amplified using short tandem repeats
      (STRs), stochastic effects such as allele and locus dropout or drop-in, allele
      imbalance, and increased stutter often occur making data interpretation more
      difficult. The most common approach to improving STR results from low template
      samples is to increase the number of PCR cycles. Although more alleles may be
      recovered, stochastic effects may be exaggerated resulting in more complicated
      STR profiles. This work reports the effect of additional PCR cycles (29 vs. 30,
      31, and 32) on STR success from environmentally challenged bone and tooth samples
      using the GlobalFiler(r) DNA Amplification Kit (Thermo Fisher Scientific). In
      addition, we compared the efficiency of two DNA extraction kits for skeletal
      samples: QIAamp(r) DNA Investigator (QIAGEN) and PrepFiler(r) BTATM Forensic DNA
      Extraction (Thermo Fisher Scientific) kits. Results showed that more DNA was
      recovered from samples using the PrepFiler(r) BTATM kit; but regardless of the
      extraction method, the number of alleles detected and the peak heights both
      increased with an increase in PCR cycle number. Although more alleles were
      reported in almost all samples, the most notable improvement was observed in
      samples with the DNA template < 120 pg. A general increase in the number of PCR
      artifacts was detected in STR profiles generated using 30-32 cycles. Overall,
      this study provides supporting evidence that STR profile completeness and quality
      may be improved when low template skeletal samples are amplified with extra PCR
      cycles (up to 32 cycles) using the GlobalFiler(r) DNA Amplification Kit.

PMID- 29845344
TI  - [Hyperopic Laser-in-situ-Keratomileusis after trifocal intraocular lens
      implantation : Aberration-free femto-Laser-in-situ-Keratomileusis treatment after
      implantation of a diffractive, multifocal, toric intraocular lens-case analysis].
AB  - A 52-year-old highly myopic female patient was implanted with a multifocal,
      diffractive, toric intraocular lens because of the wish to be independent of
      eyeglasses. Despite high-quality, extensive preoperative examinations, a
      hyperopic refractive error remained postoperatively, which led to the patient's
      dissatisfaction. This error was treated with Laser-in-situ-Keratomileusis
      (LASIK). After corneal LASIK treatment and implantation of a diffractive toric
      multifocal intraocular lens the patient showed a good postoperative visual result
      without optical phenomena.

PMID- 29845345
TI  - The role of sex hormone-binding globulin (SHBG), testosterone, and other sex
      steroids, on the development of type 2 diabetes in a cohort of community-dwelling
      middle-aged to elderly men.
AB  - AIMS: Contrasting findings exist regarding the association between circulating
      sex hormone-binding globulin (SHBG) and testosterone levels and type 2 diabetes
      (T2D) in men. We examined prospective associations of SHBG and sex steroids with
      incident T2D in a cohort of community-dwelling men. METHODS: Participants were
      from a cohort study of community-dwelling (n = 2563), middle-aged to elderly men
      (35-80 years) from Adelaide, Australia (the Men Androgen Inflammation Lifestyle
      Environment and Stress (MAILES) study). The current study included men who were
      followed for 5 years and with complete SHBG and sex steroid levels (total
      testosterone (TT), dihydrotestosterone (DHT) and oestradiol (E2)), but without
      T2D at baseline (n = 1597). T2D was identified by either self-report, fasting
      glucose (>= 7.0 mmol/L), HbA1c (>= 6.5%/48.0 mmol/mol), and/or prescriptions for
      diabetes medications. Logistic binomial regression was used to assess
      associations between SHBG, sex steroids and incident T2D, adjusting for
      confounders including age, smoking status, physical activity, adiposity, glucose,
      triglycerides, symptomatic depression, SHBG and sex steroid levels. RESULTS:
      During an average follow-up of 4.95 years, 14.5% (n = 232) of men developed new
      T2D. Multi-adjusted models revealed an inverse association between baseline SHBG,
      TT, and DHT levels, and incident T2D (odds ratio (OR) = 0.77, 95% CI [0.62,
      0.95], p = 0.02; OR 0.70 [0.57, 0.85], p < 0.001 and OR 0.78 [0.63, 0.96], p =
      0.02), respectively. However, SHBG was no longer associated with incident T2D
      after additional adjustment for TT (OR 0.92 [0.71, 1.17], p = 0.48; TT in
      incident T2D: OR 0.73 [0.57, 0.92], p = 0.01) and after separate adjustment for
      DHT (OR 0.83 [0.64, 1.08], p = 0.16; DHT in incident T2D: OR 0.83 [0.65, 1.05], p
      = 0.13). There was no observed effect of E2 in all models of incident T2D.
      CONCLUSIONS: In men, low TT, but not SHBG and other sex steroids, best predicts
      the development of T2D after adjustment for confounders.

PMID- 29845346
TI  - Correlates of DSM-5 Autism Spectrum Disorder Levels of Support Ratings in a
      Clinical Sample.
AB  - The DSM-5 features level of support ratings for social communication (SC) and
      restrictive and repetitive behaviors (RRB) for individuals with autism spectrum
      disorder (ASD). We contrasted cognitive, adaptive, and autism severity scores
      across SC and RRB groups for 158 individuals with ASD diagnosed in a
      developmental disabilities clinic. Roughly 46% of individuals were identified by
      licensed psychologists' clinical judgement as needing Level 2 SC support and 49%
      were identified as needing Level 2 RRB support. No individuals were rated as
      needing a combination of Level 1/Level 3 supports across domains. MANOVA and
      direct discriminant analysis revealed that both SC and RRB groups showed a graded
      pattern of higher adaptation/lower autism severity to lower adaptation/higher
      autism severity from Level 1 to Level 3.

PMID- 29845347
TI  - Y-90 Radioembolization Combined with a PD-1 Inhibitor for Advanced Hepatocellular
      Carcinoma.
AB  - Nivolumab has recently received approval by the Food and Drug Administration for
      treatment of advanced hepatocellular carcinoma (HCC) in patients previously
      treated with sorafenib. Nivolumabs' overall response rate of 20% (El-Khoueiry et
      al. in Lancet 389:2492-2502, 2017) is a step forward for these patients, but
      there is significant room for improvement. We describe a case of combining Y-90
      radioembolization with nivolumab for treatment of angioinvasive HCC, which
      successfully bridged patient to partial hepatectomy. Surgical pathology showed
      negative margins with complete pathological response. With the introduction of
      immunotherapy for HCC, combining Y-90 radioembolization with immunotherapy may
      enhance the anti-tumoral immune response of checkpoint inhibitors.

PMID- 29845348
TI  - Microwave Ablation in the Management of Colorectal Cancer Pulmonary Metastases.
AB  - PURPOSE: To review outcomes following microwave ablation (MWA) of colorectal
      cancer pulmonary metastases and assess predictors of oncologic outcomes. METHODS:
      Technical success, primary and secondary technique efficacy rates were evaluated
      for 50 patients with 90 colorectal cancer pulmonary metastases at immediate, 4-8
      weeks post-MWA and subsequent follow-up CT and/or 18F-FDG PET/CT. Local tumor
      progression (LTP) rate, LTP-free survival (LTPFS), cancer-specific and overall
      survivals were assessed. Complications were recorded according to SIR
      classification. RESULTS: Median follow-up was 25.6 months. Median tumor size was
      1 cm (0.3-3.2 cm). Technical success, primary and secondary technique efficacy
      rates were 99, 90 and 92%, respectively. LTP rate was 10%. One-, 2- and 3-year
      LTPFS were: 93, 86 and 86%, respectively, with median LTPFS not reached. Median
      overall survival was 58.6 months, and median cancer-specific survival (CSS) was
      not reached. One-, 2- and 3-year overall and CSS were 94% and 98, 82 and 90%, 61
      and 70%, respectively. On univariate analysis, minimal ablation margin (p <
      0.001) and tumor size (p = 0.001) predicted LTPFS, with no LTP for minimal margin
      >= 5 mm and/or tumor size < 1 cm. Pleural-based metastases were associated with
      increased LTP risk (p = 0.002, SHR = 7.7). Pre-MWA CEA level > 10 ng/ml (p =
      0.046) and >= 3 prior chemotherapy lines predicted decreased CSS (p = 0.02).
      There was no 90-day death. Major complications rate was 13%. CONCLUSIONS: MWA
      with minimal ablation margin >= 5 mm is essential for local control of colorectal
      cancer pulmonary metastases. Pleural-based metastases and larger tumor size were
      associated with higher risk of LTP. CEA level and pre-MWA chemotherapy impacted
      CSS.

PMID- 29845350
TI  - Phylogenetic analysis of porcine reproductive and respiratory syndrome virus
      isolates from Northern Ireland.
AB  - To investigate the genetic diversity of porcine reproductive and respiratory
      syndrome virus (PRRSV) in Northern Ireland, the ORF5 gene from nine field
      isolates was sequenced and phylogenetically analysed. The results revealed
      relatively high diversity amongst isolates, with 87.6-92.2% identity between
      farms at the nucleotide level and 84.1-93.5% identity at the protein level.
      Phylogenetic analysis confirmed that all nine isolates belonged to the European
      (type 1) genotype and formed a cluster within the subtype 1 subgroup. This study
      provides the first report on PRRSV isolate diversity in Northern Ireland.

PMID- 29845349
TI  - Alternative splicing and cancer metastasis: prognostic and therapeutic
      applications.
AB  - Metastatic cells exhibit an extraordinary phenotypic plasticity, not only in
      adapting to unfamiliar microenvironments but also in surviving aggressive
      treatments and immune responses. A major source of phenotypic variability is
      alternative splicing (AS) of the pre-messenger RNA. This process is catalyzed by
      one of the most complex pieces of cellular molecular regulatory events, the
      spliceosome, which is composed of ribonucleoproteins and polypeptides termed
      spliceosome factors. With strong evidence indicating that AS affects nearly all
      genes encoded by the human genome, aberrant AS programs have a significant impact
      on cancer cell development and progression. In this review, we present insights
      about the genomic and epigenomic factors affecting AS, summarize the most recent
      findings linking aberrant AS to metastatic progression, and highlight potential
      prognostic and therapeutic applications.

PMID- 29845351
TI  - Antiviral prophylaxis during chemotherapy or immunosuppressive drug therapy to
      prevent HBV reactivation in patients with resolved HBV infection: a systematic
      review and meta-analysis.
AB  - BACKGROUND: Until recently, the role of antiviral prophylaxis in preventing
      hepatitis B virus (HBV) reactivation during immunosuppressive therapy or
      chemotherapy in patients with resolved HBV infection was unclear. The aim of the
      study reported here was to compare the efficacy of antiviral prophylaxis versus
      that of non-prophylaxis in resolved HBV-infected patients undergoing chemotherapy
      or immunosuppressive therapy. METHODS: PubMed, the Cochrane library, and the
      ClinicalTrials.gov website were searched from inception until December 2017.
      Studies comparing reactivation in prophylaxis versus non-prophylaxis in patients
      undergoing immunosuppressive therapy or chemotherapy were included. The meta
      analysis was performed to calculate the relative risk (RR) and the pooled
      estimates. RESULTS: A meta-analysis was conducted of 13 studies (2 randomized
      controlled trials [RCTs] and 11 cohort studies). The summary RR for HBV
      reactivation was 0.47 (95% confidence interval [CI] 0.13-1.69) for antiviral
      prophylaxis versus non-prophylaxis. Both of the RCTs included in the meta
      analysis enrolled patients treated with rituximab. Subgroup analyses showed that
      the two RCTs +/- high-quality cohort studies showed a decreased risk of HBV
      reactivation among the antiviral prophylaxis groups (RCT 1: RR 0.13, 95% CI 0.02
      0.70; P = 0.02; RCT 2: 0.28, 95% CI 0.08-0.98; P = 0.05). Subgroup analyses
      further showed that the cohort studies did not support an association between the
      antiviral prophylaxis groups and HBV reactivation (RR 0.62, 95% CI 0.14-2.83; P =
      0.54); adjusting for confounding factors, such as detectable anti-HBs antibodies,
      failed to produce a significant association (RR,0.29, 95% CI 0.07-1.28; P =
      0.10). CONCLUSION: Our meta-analyses did not show an association between
      antiviral prophylaxis use and risk of HBV reactivation. As using only the RCTs +/
      high-quality cohort studies data rendered this association significant,
      clinicians can consider providing antiviral prophylaxis to patients with resolved
      HBV infection who are undergoing rituximab-based therapy.

PMID- 29845352
TI  - Effect of cross-linking on the physicochemical and in vitro properties of
      pullulan/dextran microbeads.
AB  - Hydrogels are very promising for tissue engineering as they provide scaffolds and
      a suitable microenvironment to control cell behavior and tissue regeneration. We
      used a patented method to obtain beads of pullulan/dextran cross-linked with
      sodium trimetaphosphate (STMP), that were already described for in vivo bone
      repair. The aim of this study was to provide a comparative analysis of microbeads
      made of polysaccharides prepared using three different STMP feeding ratio of 1.5,
      2.25 or 3 % w/w. The morphology, swelling and biodegradability of these
      structures were assessed. Mesenchymal stem cells were also seeded to evaluate the
      cell organization onto the beads. We found that the amount of phosphorus
      resulting from the cross-linking was proportional to the introduced STMP
      concentration. An increase of cross-linking decreased the in vitro enzymatic
      degradability, and also decreased the swelling in PBS or water. The
      microstructures observed by SEM and confocal microscopy indicated that
      homogeneous spherical microbeads were obtained, except for the lower cross
      linking ratio where the shapes were altered. Beads hydrated in PBS exhibited a
      mean diameter ranging from 400 to 550 um with the decrease of STMP ratio. Cells
      adhered to the surface of microbeads even in the absence of protein coating. Cell
      viability studies revealed an increase in cell numbers over two weeks for the
      highest cross-linked beads, whereas the two lowest STMP concentrations induced a
      decrease of cell viability. Overall, this study demonstrated that
      pullulan/dextran hydrogels can be designed as microbeads with adjustable
      physicochemical and biological properties to fulfill requirements for tissue
      engineering approaches.

PMID- 29845353
TI  - Molecular level responses to chronic versus pulse nutrient loading in the
      seagrass Posidonia oceanica undergoing herbivore pressure.
AB  - Seagrasses are key marine foundation species, currently declining due to the
      compounded action of global and regional anthropogenic stressors. Eutrophication
      has been associated with seagrass decline, while grazing has been traditionally
      considered to be a natural disturbance with a relatively low impact on
      seagrasses. In the recent years, this assumption has been revisited. Here, by
      means of a 16-month field-experiment, we investigated the molecular mechanisms
      driving the long-term response of Posidonia oceanica to the combination of
      nutrient enrichment, either as a chronic (press) or pulse disturbance, and
      herbivory. Changes in expression levels of 19 target genes involved in key steps
      of photosynthesis, nutrient assimilation, chlorophyll metabolism, oxidative
      stress response and plant defense were evaluated through reverse transcription
      quantitative polymerase chain reaction (RT-qPCR). High herbivore pressure
      affected the molecular response of P. oceanica more dramatically than did
      enhanced nutrient levels, altering the expression of genes involved in plant
      tolerance and resistance traits, such as photosynthesis and defense mechanisms.
      Genes involved in carbon fixation and N assimilation modulated the response of
      plants to high nutrient levels. Availability of resources seems to modify P.
      oceanica response to herbivory, where the upregulation of a nitrate transporter
      gene was accompanied by the decline in the expression of nitrate reductase in the
      leaves, suggesting a change in plant-nutrient allocation strategy. Finally, press
      and pulse fertilizations altered nitrate uptake and reduction-related genes in
      opposite ways, suggesting that taking into account the temporal regime of
      nutrient loading is important to assess the physiological response of seagrasses
      to eutrophication.

PMID- 29845354
TI  - Correction to: Roles and maturation of iron-sulfur proteins in plastids.
AB  - With the author(s)' decision to opt for Open Choice the copyright of the article
      changed.

PMID- 29845355
TI  - Correction to: Fe-S cluster assembly in the supergroup Excavata.
AB  - The article "Fe-S cluster assembly in the supergroup Excavata", written by
      Priscila Pena-Diaz, Julius Lukes was originally published electronically on the
      publisher's internet portal (currently SpringerLink) without open access.

PMID- 29845356
TI  - Correction to: Maturation of the [Ni-4Fe-4S] active site of carbon monoxide
      dehydrogenases.
AB  - Correction to: JBIC Journal of Biological Inorganic Chemistry.

PMID- 29845357
TI  - Serological diagnosis of Mycoplasma pneumoniae infection by using the mimic
      epitopes.
AB  - Nowadays, there is lack of effective serological detection method for Mycoplasma
      pneumoniae (M. pneumoniae) infection in clinic. In this study, the mimic epitopes
      of M. pneumoniae were screened to evaluate the role in the serodiagnosis of M.
      pneumoniae infection. The M. pneumoniae-positive serum was used as the target for
      biopanning to phage display random 7-peptide library. The positive phage clones
      were selected and the DNA were sequenced and analyzed by BLAST. The
      representative phages were identified using dot immunoblotting and ELISA. The
      exogenous heptapeptides were synthesized and their reactions with M. pneumonia
      positive serum were tested by indirect ELISA. Two heptapeptides, namely
      heptapeptide 1: TVNFKLY and heptapeptide 2: LPQRLRT, were screened out from the
      randomly selected 40 phages after the four bio-panning rounds. They had high
      homologies to some M. pneumoniae antigens. Besides, the representative
      bacteriophage containing heptapeptide 1 or 2 could react with the M. pneumonia-
      positive serum. The sensitivities of heptapeptide 1 and heptapeptide 2 for the
      diagnosis of M. pneumoniae infection were 90.1 and 80.0%, respectively, and the
      specificities were 94.3 and 97.1%, respectively. Therefore the two heptapeptides
      were the mimic epitopes of M. pneumoniae and might have potential serological
      diagnosis value for M. pneumoniae infection.

PMID- 29845358
TI  - Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging
      features.
AB  - Pleomorphic adenoma (PA) is the most common salivary gland tumor and is
      characterized by cytomorphological and architectural diversity. On CT and MR
      images, PAs are shown as well-defined lesions occasionally accompanied by
      characteristic lobulated contours. On T2-weighted images, typical PAs show marked
      hyperintensity, which reflects the abundant myxochondroid stroma, with a
      hypointense rim indicating the fibrous capsule. However, intratumoral signal
      intensity varies according to the cellular density, proportion of epithelial and
      stromal components, and type of stromal components. In addition, a variety of
      secondary histological changes, including fibrosis, lipometaplasia, ossification,
      cystic degeneration, and infarction, occur rarely in PAs; therefore, they are
      associated with difficulty in differential diagnosis from other salivary gland
      tumors. This review article describes the common and uncommon CT and MR imaging
      features of PA of the salivary glands.

PMID- 29845359
TI  - Self-efficacy for self-regulation and fear of failure as mediators between self
      esteem and academic procrastination among undergraduates in health professions.
AB  - Academic procrastination has been a widespread problem behavior among
      undergraduates. This study aimed to examine the prevalence of academic
      procrastination among undergraduates in health professions, and explore the
      mediation effects of self-efficacy for self-regulation and fear of failure in the
      relationship between self-esteem and academic procrastination. A cross-sectional
      design was used to study 1184 undergraduates in health professions from China.
      Participants completed measures of academic procrastination, self-esteem, self
      efficacy for self-regulation and fear of failure. We used Pearson product-moment
      correlation to examine the bivariate correlations between study variables, and
      path analysis to examine mediation. Among the 1184 undergraduates, 877 (74.1%)
      procrastinated on at least one type of academic task. The total score for
      academic procrastination was negatively correlated with scores for self-esteem
      and self-efficacy for self-regulation, and positively correlated with the score
      for fear of failure. Moreover, the relationship between self-esteem and academic
      procrastination was fully mediated by self-efficacy for self-regulation (indirect
      effect: beta = - .15, 95% bootstrap CI - .19 to - .11) and fear of failure
      (indirect effect: beta = - .06, 95% bootstrap CI - .09 to - .04). These findings
      suggest that interventions targeting the enhancement of self-efficacy for self
      regulation and the conquest of fear of failure may prevent or reduce academic
      procrastination among undergraduates in health professions, especially for those
      with lower self-esteem.

PMID- 29845360
TI  - HLA-G expression in gastric carcinoma: clinicopathological correlations and
      prognostic impact.
AB  - To analyze expression of human leukocyte antigen-G (HLA-G) in gastric
      adenocarcinoma and correlate its expression with histological and clinical
      variables. A continuous series of 94 unselected patients with gastric
      adenocarcinoma (stage I to III) were selected. All histological and clinical
      variables were collected including the intensity of intra- and peri-tumor
      lymphocytic infiltration. HLA-G expression was investigated using
      immunohistochemistry. All histological samples analyzed for HLA-G expression were
      taken from the primary gastric lesion and included non-neoplastic mucosa.
      Evaluation of HLA-G expression was performed on the transition zone between tumor
      and non-neoplastic mucosa, and the invasive front of the tumor and assessment was
      performed as follows: percentage of positive (strong expression vs weak) cells. A
      variable amount of HLA-G-positive tumor cells was found in 24 out of 94 cases
      (25.5%). No significant correlation was found between HLA-G expression and other
      clinicopathological variables (sex, age, stage, grade, histotype). The overall
      median survival was worse in patients with HLA-G-positive adenocarcinoma (24.3
      months, CI95% 7.7-41.0) compared to those with HLA-G-negative tumors (66.3
      months, CI95% 53.0-79.7; p < 0.0001). Two- and 5-year survival rates of HLA-G
      negative patients were 88 and 44%, respectively, while were 42 and 11% in those
      HLA-G-positive. This trend was observed in all stages but was more marked in
      stage III. HLA-G expression is associated with poor survival in stage III gastric
      cancer patients and represents a possible immunoescape mechanism of cancer cells.

PMID- 29845362
TI  - Increased intermediate monocyte fraction in peripheral blood is associated with
      nonalcoholic fatty liver disease.
AB  - Nonalcoholic fatty liver disease (NAFLD) currently represents the most common
      hepatic disease worldwide and is closely linked to cardiovascular disease,
      obesity and diabetes mellitus. This study aimed to investigate NAFLD and its
      influence on different monocyte subpopulations to determine the presence of
      significant associations. A total of 3 monocyte subpopulations were investigated,
      i.e. classical (CD14++CD16-), intermediate (CD14++CD16+) and non-classical
      (CD14+CD16++). Of the participants 261 were included in this study (n = 53 with
      NAFLD, n = 208 controls). Ultrasonography was used to diagnose NAFLD and exclude
      other morphologic causes of liver diseases and other tests (including medical
      history inquiries and detection of hepatitis virus) were performed to exclude
      other causes of parenchymal liver disease. Classical inflammatory and metabolic
      related NAFLD biomarkers were also determined. In contrast to the healthy control
      group, the intermediate monocyte fraction was increased in NAFLD patients (p =
      0.032), while the classical monocyte fraction was decreased (p = 0.025).
      Intermediate monocyte fraction, body mass index (BMI) and tumor necrosis factor
      alpha (TNF-alpha) were independent risk factors for NAFLD. Classical, non
      classical and intermediate monocytes fraction were strongly associated with age,
      triglyceride, and waist circumference. This study suggests that the intermediate
      monocyte fraction in peripheral blood is likely related to the aggravation of
      NAFLD.

PMID- 29845361
TI  - Gastric gland mucin-specific O-glycan expression decreases as tumor cells
      progress from lobular endocervical gland hyperplasia to cervical mucinous
      carcinoma, gastric type.
AB  - Gastric gland mucin-specific O-glycans are unique in having alpha1,4-linked N
      acetylglucosamine (alphaGlcNAc) attached to MUC6. We previously reported
      decreased expression of alphaGlcNAc relative to MUC6 in gastric and pancreatic
      neoplasms, but its significance in cervical glandular lesions remained unclear.
      Here, we analyzed MUC5AC, MUC6, alphaGlcNAc, and p16 expression in 9 lesions of
      mucinous carcinoma, gastric type with minimal deviation adenocarcinoma (GAS-MDA),
      5 of GAS with nonMDA (GAS-nonMDA), 14 of typical lobular endocervical gland
      hyperplasia (LEGH), and 5 of atypical LEGH (33 total lesions). All 33 were MUC5AC
      positive. Moreover, all 14 typical LEGH, 5 atypical LEGH, 8 of 9 GAS-MDA, and 3
      of 5 GAS-nonMDA were MUC6-positive. All 14 typical LEGH, 2 of 5 atypical LEGH, 3
      of 9 GAS-MDA, and 1 of 5 GAS-nonMDA were alphaGlcNAc-positive. The proportion of
      alphaGlcNAc-positive atypical LEGH or GAS-MDA or GAS-nonMDA lesions was
      significantly smaller than that seen in typical LEGH lesions (P < 0.001 and P <
      0.01, respectively). Of 33 lesions, 32 were p16-negative. Furthermore, when we
      evaluated MUC6 and alphaGlcNAc immunoreactivity semi-quantitatively in all 33
      lesions, in typical LEGH and GAS-MDA, the immunohistochemical score for
      alphaGlcNAc was significantly lower than that for MUC6 (P < 0.01). We did not
      observe significantly decreased alphaGlcNAc expression relative to MUC6 in
      typical LEGH lesions. These studies suggest that alphaGlcNAc expression decreases
      as typical LEGH progresses to GAS. Given the difficulty in distinguishing MDA and
      atypical LEGH from typical LEGH in H.E. staining, we propose that
      immunohistochemical analysis of alphaGlcNAc and MUC6 could be useful.

PMID- 29845363
TI  - [Insufficient tetanus vaccination protection in psoriasis and systemic
      immunosuppression : Results of a retrospective investigation of 101 patients].
AB  - BACKGROUND: With a prevalence of approximately 3 % worldwide, psoriasis is one of
      the most frequent chronic inflammatory skin diseases. Patients with moderate to
      severe psoriasis are treated guideline-conform with immunomodulatory or
      immunosuppressive agents. According to current guidelines physicians should be
      vigilant about the vaccination status of immunosuppressed patients. OBJECTIVE:
      The aim of the study was to serologically objectify the tetanus vaccination
      status in systemically treated patients with moderate to severe psoriasis in
      Germany. MATERIAL AND METHODS: Within the context of this retrospective study the
      concentration of immunoglobulin G antibodies against Clostridium tetani was
      determined in 101 patients with systemic immunosuppression suffering from
      psoriasis. RESULTS: In a total of 27.7% (n = 28; 11 male, 17 female) of the
      patients, insufficient immunoglobulin G antibody concentrations were detected,
      corresponding to a higher risk of an infection with C. tetani. Group subanalyses
      indicated an insufficient tetanus protection especially in patients >=65 years
      old (50%). CONCLUSION: The tetanus immune status of psoriasis patients was shown
      to be comparable with the general population. The results of our investigation
      underline that people suffering from psoriasis have to be tested for tetanus
      protection and if necessary, vaccinations have to be renewed.

PMID- 29845364
TI  - [Image-based computer diagnosis of melanoma].
AB  - The use of automated diagnostic systems for the diagnosis of melanomas is
      becoming increasingly more established. These are based on the following four
      steps: 1) preprocessing, to ensure that disturbing factors are eliminated, 2)
      segmentation, the separation of the image and the background, 3) extraction and
      selection of features that provide the highest measure of accuracy for the
      diagnosis and 4) classification, in which the lesion is assigned to a diagnostic
      class. Recently, the computer-assisted diagnosis of melanoma has focused on
      algorithms based on transfer learning, which can make steps 2 and 3 obsolete and
      provides better results. In this article we also review smartphone applications
      in the field of melanoma screening and recognition. These applications should be
      considered with caution as they are available to lay persons although the
      diagnostic accuracy of these applications has not usually been tested in clinical
      trials.

PMID- 29845365
TI  - Association of TNF-alpha-308 Polymorphism with Susceptibility to Autoimmune
      Hepatitis in Tunisians.
AB  - Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiology and several
      proinflammatory cytokines are implicated in its pathogenesis. The association of
      TNF-alpha gene polymorphism with AIH onset is not fully elucidated especially in
      the Tunisian population. The aim of this study was to determine the association
      of TNF-alpha (-308 G > A) polymorphism with AIH susceptibility and with TNF-alpha
      expression or clinical manifestations of AIH. A total of 50 AIH patients and 150
      controls were included. Evaluation of TNF-alpha polymorphism was performed by
      ARMS PCR method. A significantly higher frequence of the AA genotype was found in
      AIH patients compared to controls (34 vs. 8%, p = 0.00002, OR 5.88). The
      frequency of the A-allele was significantly higher in patients with AIH compared
      to controls (55 vs. 37.3%, p = 0.002, OR 2.05). The G-allele was significantly
      more frequent in healthy controls compared to AIH patients [43 vs. 61.3%, p =
      0.001, OR 0.47 (0.3-0.75)]. There was a positive correlation between the A/A
      genotype and a higher serum expression of TNF-alpha. The TNF*A allele confer
      susceptibility to AIH in the Tunisian patients and is associated with increased
      production of TNF-alpha. Anti-TNF antibodies could be an alternative to the use
      of corticotherapy and may avoid the exacerbated immune response in AIH.

PMID- 29845366
TI  - Postnatal development of the subarcuate fossa and subarcuate canaliculus-a
      computed tomographic study.
AB  - PURPOSE: The subarcuate fossa (SF) is an anatomical structure situated on
      posterior wall of the petrous part of the temporal bone. In older children and
      adults, SF is a shallow depression and the subarcuate canaliculus starts within
      it. Awareness of postnatal changing morphology of this region is important
      especially for otosurgeon. The aim of this paper is to characterize both SF and
      SC by means of anatomical and radiological methods. METHODS: The study was
      carried out on CT scans of 101 children, aged 1-60 months. Length of the pyramid
      (PL), the distance between the anterior semicircular canal (ASC) and the
      pyramidal apex (PLM), the outer diameter of ASC (ASCD), width under ASC (SFWM),
      the distance between the fundus of SF and ASC (SFLL), the maximal width of SF
      lateral to ASC (SFWL), the distance between the fundus of SF and posterior
      surface of the pyramid (SFL) were measured. RESULTS: Average value of all
      measured distances: PL 52.14 +/- 6.32 mm and PLM 25.73 +/- 3.47 mm (raised with
      age); ASCD 8.63 +/- 0.67 mm; SFWM 0.95 +/- 1.24 mm; SFLL 1.07 +/- 1.63 mm; SFWL
      0.76 +/- 1.19 mm; SFL 3.60 +/- 2.50 mm. CONCLUSIONS: Petrous part of the temporal
      bone grows with age up to 5 years old, whereas ASC does not. SF diminishes with
      age: lateral to ASC is well developed in newborns and infants (up to first year),
      rapidly diminishes in children aged 1-2 years and is totally absent in children >
      2 years. SF medial to ASC is constant and diminishes with age. In children older
      than 3 years morphology of SF is similar to adult.

PMID- 29845367
TI  - Intracranial Stenting after Failure of Thrombectomy with the emboTrap(r) Device.
AB  - BACKGROUND: Approved alternatives in the guidelines for acute ischemic stroke
      patients who have failed intracranial thrombectomy are lacking. Primary permanent
      intracranial stenting was initially used in the era before thrombectomy and might
      still be a useful rescue treatment in acute stroke patients suffering from
      ongoing large vessel occlusion refractory to thrombectomy. METHODS: The
      prospectively collected registry of patients with acute stroke caused by large
      vessel occlusions and treated with the emboTrap(r) device in Karolinska Hospital
      from October 2013 through March 2017 were retrospectively reviewed. Clinical
      outcome of non-recanalized patients with a thrombolysis in cerebral infarction
      (TICI) score of 0-1 after failed thrombectomy were compared with those who were
      treated with permanent intracranial stenting as rescue therapy. Favorable outcome
      was defined as modified Rankin scale 0-2. RESULTS: The emboTrap(r) device was
      used in 201 patients. Persistent re-occlusions on withdrawal of the thrombectomy
      device were seen in 26 patients (13%) and of those, 12 individuals (46%) were
      treated with intracranial stenting. Baseline National Institutes of Health stroke
      scale (NIHSS), occlusion site, and onset-to-puncture time did not differ between
      the stenting group and the non-recanalized group. During the procedure half dose
      (5/12 patients) or full dose abciximab (6/12 patients), or aspirin (1/12 patient)
      was given intravenously immediately after stent placement. In 2 patients (17%)
      multiple stents were implanted. The stenting group had better functional outcomes
      at 3 months compared to the non-stenting group with 8/12 (66%) vs. 3/14 (21.4%, p
      < 0.05). Of the patients 5 (36%) in the non-stented group had died at 3 months
      follow-up, whereas mortality in the stenting cohort was 0% (p < 0.05) and no
      symptomatic intracranial hemorrhage (ICH) occurred in either group. CONCLUSION:
      Intracranial stenting after failure of recanalization with thrombectomy led to a
      better rate of clinical outcome than leaving the patient non-recanalized. The
      required antiplatelet therapy, predominantly abciximab, did not lead to
      additional ICH.

PMID- 29845368
TI  - Specific spinal pathologies in adult patients with an acute or subacute
      atraumatic low back pain in the emergency department.
AB  - PURPOSE: The primary aim in the evaluation of patients presenting with acute or
      subacute low back pain (LBP) is to exclude a possible specific spinal pathology.
      Literature on the population-based incidences of these pathologies is scarce. The
      aim of our study was to investigate the population-based incidence of specific
      spinal pathologies as a cause of atraumatic acute or subacute LBP. METHODS: From
      our institutional database, we identified all patients with a relevant LBP
      related ICD-10 code during a visit to our emergency department (ED) in a level
      II/III teaching hospital between January 2012 and December 2014. Patients with a
      possible specific spinal pathology (cauda equina syndrome, spondylodiscitis,
      vertebral fracture, and cancer) were assessed in detail. RESULTS: A total of 900
      visits were due to atraumatic low back pain. Of these 284 (31.6%) were due to
      nonspecific LBP, and 583 (64.8%) due to radicular pain suggesting nerve root
      compression. In 33 (3.7%) cases, the LBP was caused by a specific spinal
      pathology. The annual incidences per 100,000 were 0.60 for CES, 2.1 for
      spondylodiscitis, 0.76 for cancer and 1.2 for compression fracture. CONCLUSIONS:
      The incidences of specific spinal pathologies were low. Given that LBP is a very
      common symptom, it is not surprising that the accuracy of red flag symptoms is
      poor. Each patient should be considered individually, and we advocate a low
      threshold for referral and advanced imaging in cases where a specific spinal
      pathology is suspected.

PMID- 29845369
TI  - Effectiveness of transcutaneous electrical nerve stimulation for the treatment of
      migraine: a meta-analysis of randomized controlled trials.
AB  - BACKGROUND: Migraine is now ranked as the second most disabling disorder
      worldwide reported by the Global Burden of Disease Study 2016. As a noninvasive
      neurostimulation technique, transcutaneous electrical nerve stimulation(TENS) has
      been applied as an abortive and prophylactic treatment for migraine recently. We
      conduct this meta-analysis to analyze the effectiveness and safety of TENS on
      migraineurs. METHODS: We searched Medline (via PubMed), Embase, the Cochrane
      Library and the Cochrane Central Register of Controlled Trials to identify
      randomized controlled trials, which compared the effect of TENS with sham TENS on
      migraineurs. Data were extracted and methodological quality assessed
      independently by two reviewers. Change in the number of monthly headache days,
      responder rate, painkiller intake, adverse events and satisfaction were extracted
      as outcome. RESULTS: Four studies were included in the quantitative analysis with
      161 migraine patients in real TENS group and 115 in sham TENS group. We found
      significant reduction of monthly headache days (SMD: -0.48; 95% CI: -0.73 to -
      0.23; P < 0.001) and painkiller intake (SMD: -0.78; 95% CI: -1.14 to - 0.42; P <
      0.001). Responder rate (RR: 4.05; 95% CI: 2.06 to 7.97; P < 0.001) and
      satisfaction (RR: 1.85; 95% CI: 1.31 to 2,61; P < 0.001) were significantly
      increased compared with sham TENS. CONCLUSION: This meta-analysis suggests that
      TENS may serve as an effective and well-tolerated alternative for migraineurs.
      However, low quality of evidence prevents us from reaching definitive
      conclusions. Future well-designed RCTs are necessary to confirm and update the
      findings of this analysis. SYSTEMATIC REVIEW REGISTRATION: Our PROSPERO protocol
      registration number: CRD42018085984 . Registered 30 January 2018.

PMID- 29845370
TI  - [Fractures of the anterior process of the calcaneus-frequently overlooked
      injuries following ankle sprains].
AB  - Fractures to the anterior process of the calcaneus (PAC) have long been
      considered rare injuries and have received little attention in clinical research.
      On the contrary, recent studies have reported a distinct higher incidence,
      especially following ankle sprains. Decisive reasons are that fractures of the
      PAC are regularly missed on plain radiographs and that a clinical differentiation
      from injuries to the lateral ankle ligaments is difficult. With the broad
      availability of cross-sectional imaging modalities fractures of the PAC are
      diagnosed more frequently and more reliably. The purpose of this review is to
      give an overview on the diagnostics, classification and treatment recommendations
      to this topic and discuss the studies available. To date no evidence-based
      recommendations are available for the treatment of fractures of the PAC. The few
      case reports and case series published, predominantly recommend conservative
      treatment; however, the treatment regimens vary considerably, ranging from
      immobilization in a lower leg cast (2-10 weeks) to early functional treatment
      with full weight-bearing. The surgical treatment by open reduction and internal
      fixation has been described primarily for large dislocated fractures. Surgical
      excision is considered mainly in cases of persistent pain or symptomatic non
      union following non-operative treatment. For both, non-operative and operative
      treatment, the case reports and case series report satisfactory outcomes for the
      majority of patients. Nevertheless, comparative studies and patient-rated outcome
      measures are missing. Therefore, evidence-based recommendations cannot be given.

PMID- 29845371
TI  - [Syndesmosis injuries at the ankle].
AB  - BACKGROUND: Injuries to the distal tibiofibular syndesmosis are frequent and
      continue to generate controversy due to an extensive range of diagnostic
      techniques and therapeutic options. OBJECTIVE: The aim of this review is to
      summarize the current knowledge on syndesmotic instability and to present some
      recommendations for the clinical practice for acute an chronic injuries. MATERIAL
      AND METHODS: Analysis of the current literature concerning the anatomy, etiology,
      diagnostics and treatment of syndesmosis injuries. RESULTS: Purely ligamentous
      injuries (high ankle sprains) are not associated with a latent or frank
      tibiofibular diastasis and can be treated with an extended protocol of
      physiotherapy. Relevant instability of the syndesmosis with diastasis results
      from rupture of two or more ligaments and requires surgical stabilization.
      Syndesmotic disruptions are commonly associated with bony avulsions or malleolar
      fractures. Treatment consists of anatomic reduction of the distal fibula into the
      corresponding incisura of the distal tibia and stable fixation. The proposed
      means of fixation are one or more tibiofibular screws or suture button implants.
      There is no consensus on how long to maintain fixation. Both syndesmotic screws
      and suture buttons need to be removed if symptomatic. The most frequent
      complication is syndesmotic malreduction and can be minimized with direct
      visualization and intraoperative 3D scanning. Other complications include
      hardware failure, adhesions, heterotopic ossification, tibiofibular synostosis,
      chronic instability and posttraumatic arthritis. CONCLUSION: The single most
      important prognostic factor after unstable injury of the distal tibiofibular
      syndesmosis with or without fracture is the anatomic reduction of the distal
      fibula and fitting into the tibial incisura.

PMID- 29845372
TI  - Biosynthesis of riccionidins and marchantins is regulated by R2R3-MYB
      transcription factors in Marchantia polymorpha.
AB  - R2R3-MYB transcription factors constitute the largest gene family among plant
      transcription factor families. They became largely divergent during the evolution
      of land plants and regulate various biological processes. The functions of R2R3
      MYBs are mostly characterized in seed plants but are poorly understood in non
      seed plants. Here, we examined the function of two R2R3-MYB genes of Marchantia
      polymorpha (Mapoly0073s0038 and Mapoly0006s0226) that are closely related to
      subgroup 4 of the R2R3-MYB family. We performed LC/MS/MS metabolomics, RNA-seq
      analysis and expression analysis in overexpressors and knockout mutants of
      MpMYB14 and MpMYB02. Overexpression of MpMYB14 remarkably increased the amount of
      riccionidins, which are specific anthocyanins in liverworts and a few flowering
      plants. In contrast, overexpression of MpMYB02 increased the amount of several
      marchantins, which are characteristic cyclic bis (bibenzyl ether) compounds in M.
      polymorpha and related liverworts. Knockouts of MpMYB14 and MpMYB02 abolished the
      accumulation of riccionidins and marchantins, respectively. The expression of
      MpMYB14 was up-regulated by UV-B irradiation, N deficiency, and NaCl treatment,
      whereas the expression of MpMYB02 was down-regulated by NaCl treatment. Our
      results suggest that the regulatory framework of phenolic metabolism by R2R3-MYB
      was already established in early land plants.

PMID- 29845373
TI  - The occurrence of seizures after ischemic stroke does not influence long-term
      mortality; a 26-year follow-up study.
AB  - OBJECTIVE: Epileptic seizures are a common complication after stroke. The
      relation between occurrence of seizures after stroke and long-term mortality
      remains elusive. We aimed to assess whether seizures in an early or late phase
      after ischemic stroke are an independent determinant of long-term mortality.
      METHODS: We prospectively included and followed 444 ischemic stroke patients with
      a first-ever supratentorial brain infarct for at least 2 years after their stroke
      regarding the occurrence of seizures. The final follow-up for mortality is from
      April 2015 (follow-up duration 24.5-27.8 years, mean 26.0 years, SD 0.9 years).
      We compared patients with early-onset seizures with all seizure-free patients,
      whereas the patients with late-onset seizures were compared with the 1-week
      survivors without any seizures. We used Cox-regression analyses to correct for
      possible confounding factors. RESULTS: Kaplan-Meier analysis showed significantly
      higher mortality for the patients with early-onset seizures (p = 0.002) but after
      correction for known risk factors for (long term) mortality early-onset seizures
      had no independent influence on long-term mortality (HR 1.09; 95% CI 0.64-1.85).
      In patients with late-onset seizures, no significant influence from late-onset
      seizures on long-term mortality was found (univariate p = 0.717; multivariate HR
      0.81; 95% CI 0.54-1.20). CONCLUSION: Both early-onset and late-onset seizures do
      not influence long-term mortality after ischemic stroke.

PMID- 29845374
TI  - The motor and cognitive features of Parkinson's disease in patients with
      concurrent Gaucher disease over 2 years: a case series.
AB  - We report the cognitive features and progression of Parkinson's disease (PD) in
      five patients with concurrent Gaucher disease. The patients presented at an
      earlier age than patients with sporadic PD, as previously noted by others; but in
      contrast to many previous reports, our patients followed a variable clinical
      course. While two patients developed early cognitive deficits and dementia, three
      others remained cognitively intact over the follow-up period. Thus, in this small
      case series, PD in the context of GD more closely resembles idiopathic PD in
      terms of its clinical heterogeneity in contrast to PD associated with GBA
      heterozygote mutations.

PMID- 29845375
TI  - Cognitive impairments that everybody has.

PMID- 29845376
TI  - Autoimmune hepatitis induced by a single injection of interferon-beta 1a in a
      patient with multiple sclerosis.

PMID- 29845377
TI  - Infectious agents and amyotrophic lateral sclerosis: another piece of the puzzle
      of motor neuron degeneration.
AB  - Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease
      affecting motor neurons (MN). This fatal disease is characterized by progressive
      muscle wasting and lacks an effective treatment. ALS pathogenesis has not been
      elucidated yet. In a small proportion of ALS patients, the disease has a familial
      origin, related to mutations in specific genes, which directly result in MN
      degeneration. By contrast, the vast majority of cases are though to be sporadic,
      in which genes and environment interact leading to disease in genetically
      predisposed individuals. Lately, the role of the environment has gained relevance
      in this field and an extensive list of environmental conditions have been
      postulated to be involved in ALS. Among them, infectious agents, particularly
      viruses, have been suggested to play an important role in the pathogenesis of the
      disease. These agents could act by interacting with some crucial pathways in MN
      degeneration, such as gene processing, oxidative stress or neuroinflammation. In
      this article, we will review the main studies about the involvement of
      microorganisms in ALS, subsequently discussing their potential pathogenic effect
      and integrating them as another piece in the puzzle of ALS pathogenesis.

PMID- 29845379
TI  - Assessment of mechanical stability of rapidly separating microneedles for
      transdermal drug delivery.
AB  - The rapidly separating microneedles (RS-PP-MNs), composed of PVA (separable arrow
      head) MNs and a poly(L-lactide-co-D, L-lactide) (PLA) supporting array, are used
      for transdermal delivery system at high humidity. The fabricated RS-PP-MNs should
      have sufficient mechanical strength at different humidity. In general, the water
      adsorption rate was increased with increasing humidity; by contrast, storage time
      was decreased with increasing humidity. The higher water adsorption rate
      indicated the lower mechanical strength, thereby lowering drug delivery
      efficiency. The prepared RS-PP-MNs could be successfully inserted within the skin
      at high humid atmosphere due to PLA supporting array. The bright field and
      fluorescence microscopic images suggested the probable real-time applicability of
      RS-PP-MNs. The in vitro and in vivo assay suggested that RS-PP-MNs potentially
      were able to deliver the drugs at high humidity condition. The significant
      improvement in the drug delivery efficiency and skin penetration ability was
      observed compared with the traditional MNs. In addition, the fabrication of RS-PP
      MNs is facile and scalable. Therefore, the prepared RS-PP-MNs with supporting
      solid PLA array might be advantageous in real-time applications. This study is of
      great importance for the MN field as it offers more theoretical support for
      clinical applications.

PMID- 29845378
TI  - Neuronal network-based mathematical modeling of perceived verticality in acute
      unilateral vestibular lesions: from nerve to thalamus and cortex.
AB  - Acute unilateral lesions of vestibular graviceptive pathways from the otolith
      organs and semicircular canals via vestibular nuclei and the thalamus to the
      parieto-insular vestibular cortex regularly cause deviations of perceived
      verticality in the frontal roll plane. These tilts are ipsilateral in peripheral
      and in ponto-medullary lesions and contralateral in ponto-mesencephalic lesions.
      Unilateral lesions of the vestibular thalamus or cortex cause smaller tilts of
      the perceived vertical, which may be either ipsilateral or contralateral. Using a
      neural network model, we previously explained why unilateral vestibular midbrain
      lesions rarely manifest with rotational vertigo. We here extend this approach,
      focussing on the direction-specific deviations of perceived verticality in the
      roll plane caused by acute unilateral vestibular lesions from the labyrinth to
      the cortex. Traditionally, the effect of unilateral peripheral lesions on
      perceived verticality has been attributed to a lesion-based bias of the otolith
      system. We here suggest, on the basis of a comparison of model simulations with
      patient data, that perceived visual tilt after peripheral lesions is caused by
      the effect of a torsional semicircular canal bias on the central gravity
      estimator. We further argue that the change of gravity coding from a
      peripheral/brainstem vectorial representation in otolith coordinates to a
      distributed population coding at thalamic and cortical levels can explain why
      unilateral thalamic and cortical lesions have a variable effect on perceived
      verticality. Finally, we propose how the population-coding network for gravity
      direction might implement the elements required for the well-known perceptual
      underestimation of the subjective visual vertical in tilted body positions.

PMID- 29845380
TI  - Curcumin-loaded self-nanomicellizing solid dispersion system: part I:
      development, optimization, characterization, and oral bioavailability.
AB  - Curcumin (CUR) is considered as one of the most bioactive molecules ever
      discovered from nature due to its proven anti-inflammatory and antioxidant in
      both preclinical and clinical studies. Despite its proven safety and efficacy,
      the clinical translation of CUR into a useful therapeutic agent is still limited
      due to its poor oral bioavailability. To overcome its limitation and enhance oral
      bioavailability by improving its aqueous solubility, stability, and intestinal
      permeability, a novel CUR formulation (NCF) was developed using the self
      nanomicellizing solid dispersion strategy. From the initial screening of polymers
      for their potential to improve the solubility and stability, Soluplus (SOL) was
      selected. The optimized NCF demonstrated over 20,000-fold improvement in aqueous
      solubility as a result of amorphization, hydrogen bonding interaction, and
      micellization determined using differential scanning calorimetry, X-ray
      diffraction, scanning electron microscopy, Fourier transform infrared
      spectroscopy, nuclear magnetic resonance, dynamic light scattering, and
      transmission electron microscopy. Moreover, the greater stabilizing effect in
      alkaline pH and light was observed. Furthermore, significant enhancement of
      dissolution and permeability of CUR across everted sacs of rat small intestine
      were noticed. Pharmacokinetic studies demonstrated that the oral bioavailability
      of CUR was increased 117 and 17-fold in case of NCF and physical mixture of CUR
      and SOL compared to CUR suspension. These results suggest NCF identified as a
      promising new approach for repositioning of CUR for pharmaceutical application by
      enhancing the oral bioavailability of CUR. The findings herein stimulate further
      in vivo evaluations and clinical tests of NCF.

PMID- 29845381
TI  - Effects of Flow Disruptions on Mental Workload and Surgical Performance in
      Robotic-Assisted Surgery.
AB  - BACKGROUND: Robotic systems introduced new surgical and technical demands.
      Surgical flow disruptions are critical for maintaining operating room (OR)
      teamwork and patient safety. Specifically for robotic surgery, effects of intra
      operative disruptive events for OR professionals' workload, stress, and
      performance have not been investigated yet. This study aimed to identify flow
      disruptions and assess their association with mental workload and performance
      during robotic-assisted surgery. METHODS: Structured expert-observations to
      identify different disruption types during 40 robotic-assisted radical
      prostatectomies were conducted. Additionally, 216 postoperative reports on mental
      workload (mental demands, situational stress, and distractions) and performance
      of all OR professionals were collected. RESULTS: On average 15.8 flow disruptions
      per hour were observed with the highest rate after abdominal insufflation and
      before console time. People entering the OR caused most flow disruptions.
      Disruptions due to equipment showed the highest severity of interruption.
      Workload significantly correlated with severity of disruptions due to
      coordination and communication. CONCLUSIONS: Flow disruptions occur frequently
      and are associated with increased workload. Therefore, strategies are needed to
      manage disruptions to maintain OR teamwork and safety during robotic-assisted
      surgery.

PMID- 29845382
TI  - Comparative analysis of strategies to prepare electron sinks in aquatic
      photoautotrophs.
AB  - While subject to illumination, photosystem I (PSI) has the potential to produce
      reactive oxygen species (ROS) that can cause photo-oxidative damage in oxygenic
      photoautotrophs. The reaction center chlorophyll in PSI (P700) is kept oxidized
      in excess light conditions to limit over-excitation of PSI and alleviate the
      production of ROS. Oxidation of P700 requires a sufficient electron sink for PSI,
      which is responsible for flavodiiron proteins (FLV) safely dissipating electrons
      to O2 in cyanobacteria, green algae, and land plants except for angiosperms
      during short-pulse light (SP) illumination under which photosynthesis and
      photorespiration do not occur. This fact implies that O2 usage is essential for
      P700 oxidation but also raises the question why angiosperms lost FLV. Here, we
      first found that aquatic photoautotrophs in red plastid lineage, in which no gene
      for FLV has been found, could keep P700 oxidized during SP illumination
      alleviating the photo-oxidative damage in PSI even without O2 usage. We
      comprehensively assessed P700 oxidation during SP illumination in the presence
      and absence of O2 in cyanobacteria (Cyanophyta), green algae (Chlorophyta),
      angiosperms (Streptophyta), red algae (Rhodophyta), and secondary algae
      (Cryptophyta, Haptophyta, and Heterokontophyta). A variety of dependencies of
      P700 oxidation on O2 among these photoautotrophs clearly suggest that O2 usage
      and FLV are not universally required to oxidize P700 for protecting PSI against
      ROS damage. Our results expand the understanding of the diverse strategies taken
      by oxygenic photoautotrophs to oxidize P700 and mitigate the risks of ROS.

PMID- 29845383
TI  - Effect of Neuromodulation of Short-term Plasticity on Information Processing in
      Hippocampal Interneuron Synapses.
AB  - Neurons in a micro-circuit connected by chemical synapses can have their
      connectivity affected by the prior activity of the cells. The number of synapses
      available for releasing neurotransmitter can be decreased by repetitive
      activation through depletion of readily releasable neurotransmitter (NT), or
      increased through facilitation, where the probability of release of NT is
      increased by prior activation. These competing effects can create a complicated
      and subtle range of time-dependent connectivity. Here we investigate the
      probabilistic properties of facilitation and depression (FD) for a presynaptic
      neuron that is receiving a Poisson spike train of input. We use a model of FD
      that is parameterized with experimental data from a hippocampal basket cell and
      pyramidal cell connection, for fixed frequency input spikes at frequencies in the
      range of theta (3-8 Hz) and gamma (20-100 Hz) oscillations. Hence our results
      will apply to micro-circuits in the hippocampus that are responsible for the
      interaction of theta and gamma rhythms associated with learning and memory. A
      control situation is compared with one in which a pharmaceutical neuromodulator
      (muscarine) is employed. We apply standard information-theoretic measures such as
      entropy and mutual information, and find a closed form approximate expression for
      the probability distribution of release probability. We also use techniques that
      measure the dependence of the response on the exact history of stimulation the
      synapse has received, which uncovers some unexpected differences between control
      and muscarine-added cases.

PMID- 29845384
TI  - Delineating managed land for reporting national greenhouse gas emissions and
      removals to the United Nations framework convention on climate change.
AB  - Land use and management activities have a substantial impact on carbon stocks and
      associated greenhouse gas emissions and removals. However, it is challenging to
      discriminate between anthropogenic and non-anthropogenic sources and sinks from
      land. To address this problem, the Intergovernmental Panel on Climate Change
      developed a managed land proxy to determine which lands are contributing
      anthropogenic greenhouse gas emissions and removals. Governments report all
      emissions and removals from managed land to the United Nations Framework
      Convention on Climate Change based on this proxy, and policy interventions to
      reduce emissions from land use are expected to focus on managed lands. Our
      objective was to review the use of the managed land proxy, and summarize the
      criteria that governments have applied to classify land as managed and unmanaged.
      We found that the large majority of governments are not reporting on their
      application of the managed land proxy. Among the governments that do provide
      information, most have assigned all area in specific land uses as managed, while
      designating all remaining lands as unmanaged. This designation as managed land is
      intuitive for croplands and settlements, which would not exist without management
      interventions, but a portion of forest land, grassland, and wetlands may not be
      managed in a country. Consequently, Brazil, Canada and the United States have
      taken the concept further and delineated managed and unmanaged forest land,
      grassland and wetlands, using additional criteria such as functional use of the
      land and accessibility of the land to anthropogenic activity. The managed land
      proxy is imperfect because reported emissions from any area can include non
      anthropogenic sources, such as natural disturbances. However, the managed land
      proxy does make reporting of GHG emissions and removals from land use more
      tractable and comparable by excluding fluxes from areas that are not directly
      influenced by anthropogenic activity. Moreover, application of the managed land
      proxy can be improved by incorporating additional criteria that allow for further
      discrimination between managed and unmanaged land.

PMID- 29845385
TI  - Modulation of hepatic inflammation and energy-sensing pathways in the rat liver
      by high-fructose diet and chronic stress.
AB  - PURPOSE: High-fructose consumption and chronic stress are both associated with
      metabolic inflammation and insulin resistance. Recently, disturbed activity of
      energy sensor AMP-activated protein kinase (AMPK) was recognized as mediator
      between nutrient-induced stress and inflammation. Thus, we analyzed the effects
      of high-fructose diet, alone or in combination with chronic stress, on glucose
      homeostasis, inflammation and expression of energy sensing proteins in the rat
      liver. METHODS: In male Wistar rats exposed to 9-week 20% fructose diet and/or 4
      week chronic unpredictable stress we measured plasma and hepatic corticosterone
      level, indicators of glucose homeostasis and lipid metabolism, hepatic
      inflammation (pro- and anti-inflammatory cytokine levels, Toll-like receptor 4,
      NLRP3, activation of NFkappaB, JNK and ERK pathways) and levels of energy-sensing
      proteins AMPK, SIRT1 and peroxisome proliferator-activated receptor gamma
      coactivator-1 alpha (PGC-1alpha). RESULTS: High-fructose diet led to glucose
      intolerance, activation of NFkappaB and JNK pathways and increased intrahepatic
      IL-1beta, TNFalpha and inhibitory phosphorylation of insulin receptor substrate 1
      on Ser307. It also decreased phospho-AMPK/AMPK ratio and increased SIRT1
      expression. Stress alone increased plasma and hepatic corticosterone but did not
      influence glucose tolerance, nor hepatic inflammatory or energy-sensing proteins.
      After the combined treatment, hepatic corticosterone was increased, glucose
      tolerance remained preserved, while hepatic inflammation was partially prevented
      despite decreased AMPK activity. CONCLUSION: High-fructose diet resulted in
      glucose intolerance, hepatic inflammation, decreased AMPK activity and reduced
      insulin sensitivity. Chronic stress alone did not exert such effects, but when
      applied together with high-fructose diet it could partially prevent fructose
      induced inflammation, presumably due to increased hepatic glucocorticoids.

PMID- 29845386
TI  - Production of caffeoylmalic acid from glucose in engineered Escherichia coli.
AB  - OBJECTIVES: To achieve biosynthesis of caffeoylmalic acid from glucose in
      engineered Escherichia coli. RESULTS: We constructed the biosynthetic pathway of
      caffeoylmalic acid in E. coli by co-expression of heterologous genes RgTAL,
      HpaBC, At4CL2 and HCT2. To enhance the production of caffeoylmalic acid, we
      optimized the tyrosine metabolic pathway of E. coli to increase the supply of the
      substrate caffeic acid. Consequently, an E. coli-E. coli co-culture system was
      used for the efficient production of caffeoylmalic acid. The final titer of
      caffeoylmalic acid reached 570.1 mg/L. CONCLUSIONS: Microbial production of
      caffeoylmalic acid using glucose has application potential. In addition,
      microbial co-culture is an efficient tool for producing caffeic acid esters.

PMID- 29845387
TI  - Propensity score analysis of postoperative and oncological outcomes after
      surgical treatment for splenic flexure colon cancer.
AB  - PURPOSE: The surgical treatment of splenic flexure colon cancer (SFCC) is somehow
      not yet well standardized. Postoperative and oncological results of the three
      surgical techniques most commonly used to treat SFCC: extended right colectomy
      (ERC), egmental left colectomy (SLC), and left colectomy (LC) were evaluated.
      METHODS: The study included all patients with stage I-III SFCC treated by ERC,
      SLC, or LC between 2005 and 2016. Postoperative and long-term outcomes after the
      different surgical techniques were analyzed: Propensity score matching (PSM) was
      performed to compare the outcomes between these surgical techniques and survival
      analyses were performed using the Kaplan-Meier method and log-rank tests.
      RESULTS: A total of 170 SFCC patients were operated; ERC was performed in 71
      (41.76%), SLC in 36 (21.18%), and LC in 63 (37.06%). There were no significant
      differences in the short and long-term postoperative outcomes. Three comparison
      groups were developed so that PSM could be performed between the surgical
      technique cases: ERC (n = 59) vs. LC (n = 50); ERC (n = 50) vs. SLC (n = 33); and
      SLC (n = 32) vs. LC (n = 44). No differences in the short or long-term outcomes
      of these techniques were observed. CONCLUSION: The short and long-term outcomes
      between ERC, SLC, and LC are similar. SLC should be considered oncologically as
      appropiate as the other more extensive resections.

PMID- 29845388
TI  - Management of retrorectal supralevator abscess-results of a large cohort.
AB  - PURPOSE: Proximal intersphincteric fistulas with proximal extension causing
      supralevatoric, retrorectal abscesses are a rare disease. There is only very
      limited experience, with small groups, and the limited published literature
      confirms the complexity of diagnostics and treatment. The aim of this study was
      to evaluate transrectal internal abscess drainage as planned definitive
      treatment. METHODS: We retrospectively studied medical records of all patients
      with the diagnosis of retrorectal abscesses that underwent transrectal internal
      abscess drainage in the Department of Colo-proctology of the University Medical
      Centre Mannheim (2003-2012). RESULTS: One hundred nine patients were operated on
      retrorectal abscesses, 70 (64.2%) men and 39 (35.8%) women. Mean age was 45.3
      years (18-81). In 96 cases (88.1%), only a transrectal internal abscess drainage
      was performed as planned definitive treatment. Primary healing occurred in 60
      patients (62.5%). A second transrectal internal drainage procedure was necessary
      in 27 cases (28.1%) to assure complete internal drainage. All secondary
      procedures led to subsequent healing. A combined surgical treatment due to
      coexisting fistula tracts to the perianal skin or additional ischioanal abscesses
      was required in 13 patients (11.9%), and an additional seton placement was
      performed. Nine patients (9.4%) underwent one or more reoperations due to
      previously unidentified complex coexisting fistulas. Most of these patients were
      immunosuppressed due to Crohn's disease. Internal drainage alone was successful
      in 90.6% with an overall healing rate of 94.5% for the entire population of
      complex fistulas. CONCLUSIONS: Transrectal internal abscess drainage is a safe
      and highly successful procedure for treatment of retrorectal abscess, with very
      low risk of postoperative fecal incontinence. Inflammatory bowel disease and
      immunosuppressives have a negative impact on the healing process.

PMID- 29845389
TI  - Factors Associated with Maternal-Child Transmission of HIV-1 in Southeastern
      Brazil: A Retrospective Study.
AB  - Mother-to-child transmission (MTCT) is the main mode of HIV-1 acquisition among
      young children worldwide. The goals of this study were to estimate the proportion
      of HIV MTCT and to identify factors associated with transmission. We reviewed
      data for HIV-infected pregnant women that had been reported to the National
      Information on Reportable Diseases System (SINAN) in Espirito Santo state,
      Brazil, between January 2007 and December 2012. HIV cases in children were
      followed until age 18 months. The proportion of women who transmitted HIV to
      their babies was 14% (95% CI 11-17%). In a multivariate logistic regression
      model, pregnant women who had lower than primary school education (OR 2.74; 95%
      CI 1.31-5.71), had 2 or more pregnancies during the study period (OR 2.28; 95% CI
      1.07-4.84), had emergency cesarean delivery (OR 4.32; 95% CI 1.57-11.9), and did
      not receive antiretroviral therapy during prenatal care (OR 2.41; 95% CI 1.09
      5.31) had higher odds of HIV MTCT. Effort should be made to encourage health care
      workers and pregnant women to use services for the prevention of MTCT.

PMID- 29845390
TI  - Characterization of mixing and yield stress of pretreated wheat straw slurries
      used for the production of biofuels through tomography technique.
AB  - Wheat straw is a low-cost feedstock for the production of biofuel. Pretreatment
      process is an important stage in producing biofuels since it makes the fibers
      more accessible to enzymatic hydrolysis which is the final step of producing
      biofuels. Pretreated wheat straw (PWS) slurries are non-Newtonian fluids with
      yield stress. Mixing of fluids exhibiting yield stress such as the pretreated
      wheat straw slurry results in the generation of cavern, which is a fully-mixed
      zone, around the impeller and the stationary regions elsewhere, which causes
      difficulties in the production of biofuels. In this study, the non-invasive
      electrical resistance tomography technique was utilized to determine the cavern
      dimensions as a function of the impeller type and impeller speed. The cavern
      sizes were then used to measure the yield stress of PWS slurries as a function of
      fiber size (<= 2 and <= 6 mm) and fiber concentration (6, 8, and 10 wt%).

PMID- 29845391
TI  - A Phosphomimetic Study Implicates Ser557 in Regulation of FOXP2 DNA Binding.
AB  - FOXP2 is a transcription factor expressed in multiple tissues during embryonic
      development. FOXP2 regulates transcription by binding to DNA at its DNA binding
      domain, the forkhead domain (FHD) through the recognition helix. Ser557 is a
      residue located within the recognition helix that has the potential to become
      phosphorylated posttranslationally. In this study we investigated whether
      phosphorylation of Ser557 can influence the structure and DNA binding of the
      FOXP2 FHD. We did this by constructing S557E, a phosphomimetic mutant, and
      comparing its behaviour to the wild type. The mutation did not affect the
      secondary or tertiary structure of the protein although it did decrease the
      propensity of the FOXP2 FHD to form dimers. Most notably, the mutation showed
      significantly reduced DNA binding compared to the wild type as detected using
      electrophoretic mobility shift assays. Molecular docking was also performed in
      which the wild type, phosphomimetic mutant and phosphorylated wild-type were
      docked to DNA and their interactions with DNA were compared. These results
      indicated that the wild type forms more interactions with the DNA and that the
      phosphomimetic mutant as well as the phosphorylated wild type did not associate
      as favourably with the DNA. This indicates that phosphorylation of Ser557 could
      disrupt DNA binding likely due to electrostatic and steric hindrance. This
      suggests that phosphorylation of Ser557 in the FOXP2 FHD could act as a control
      mechanism for FOXP2 and ultimately could be involved in regulation of
      transcription.

PMID- 29845392
TI  - Clinical pharmacokinetics and safety profile of single agent arsenic trioxide by
      continuous slow-rate infusion in patients with newly diagnosed acute
      promyelocytic leukemia.
AB  - PURPOSE: This study evaluated pharmacokinetics (PK) and safety profiles of single
      agent arsenic trioxide (ATO, As2O3) administrated as continuous slow-rate
      infusion in patients with newly diagnosed acute promyelocytic leukemia. PATIENTS
      AND METHODS: Patients received 0.16 mg/kg ATO per day. ATO was given for 40 min
      infusion on the first day followed by 18-20 h daily at a very slow rate with
      infusion speed of 8 drips/min. During the first week, plasma samples were
      collected immediately before next administration on each day, and 0.5, 1, 2, 4,
      8, 12 h after administration, at the end of infusion (18 h) on day 7. Total
      arsenic was determined by ICPMS. Arsenic species, arsenious acid (AsIII) and its
      metabolites, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV), were
      quantified by UHPLC-ICPMS. Safety assessment and PK analysis was conducted.
      RESULTS: Hyperleukocytosis occurred in two patients and no severe toxicity was
      observed. Total arsenic gradually accumulated from 15.84 to 34.12 ng/mL during
      the first week of therapy. MMAV/iAs increased and remained stable at value about
      0.6 after day 4, while DMAV/MMAV declined under 2 after day 4. Compared with 2 h
      infusion, clearance (CL) of AsIII was significantly lower (0.8 +/- 0.2 vs. 2.7 +/
      1.7 L/kg/h, P = 0.002) while AUC0-t of AsIII was significantly increased (213.9
      +/- 38.6 vs. 82.6 +/- 55.7 L/kg/h, P = 0.028). CONCLUSION: Continuous slow-rate
      ATO infusion provided an alternative administration for ATO therapy with few
      toxic effects. Degree of methylation from MMA to DMA is inconsistent with that
      from iAs to MMA. PK of arsenic species is considered important for clinical use
      of ATO.

PMID- 29845393
TI  - The association of polymorphisms in folate-metabolizing genes with response to
      adjuvant chemotherapy of colorectal cancer.
AB  - BACKGROUND: Colorectal cancer (CRC) is one of the major health issues worldwide.
      5-Fluorouracil (5-FU) is a cornerstone of chemotherapy for CRC and the major
      targets of 5-FU are folate-metabolizing enzymes. METHODS: A total of 103 CRC
      patients with complete clinical data were included in this prospective cohort
      study. Genotyping was performed using polymerase chain reaction (PCR) followed by
      sequencing. Using Kaplan-Meier curves, log-rank tests, and Cox proportional
      hazard models, we evaluated associations between functional polymorphisms in four
      genes MTHFR (1298A>C and 677C>T), DPYD (496A>G and 85T>C), DHFR 19 bp del, and
      MTR (2756 A>G) with disease-free survival (DFS). RESULTS: The minor allele
      frequencies of MTHFR 1298A>C, MTHFR 677C>T, DPYD 496A>G, DPYD 85T>C, DHFR 19 bp
      del, and MTR 2756 A>G were 0.364, 0.214, 0.116, 0.209, 0.383, and 0.097,
      respectively. CRC patients carrying the homozygous GG genotype in DPYD 496A>G had
      4.36 times shorter DFS than wild-type AA carriers, (DFSGG vs AA: 8.0 +/- 4 vs
      69.0 +/- 10 months; HR 4.36, 95% CI 1.04-18; p = 0.04). Moreover, female carriers
      of homozygous CC genotype of DPYD 85T>C had shorter DFS compared to either
      heterozygous or wild-type genotypes, and were 12.7 times shorter than wild-type
      TT carriers (DFSCC vs TT: 5.0 +/- 1.5 vs 42.0 +/- 7.6 months; HR 12.7, 95% CI 2.2
      71.4; p = 0.004). However, there were no significant associations with the other
      studied polymorphisms. CONCLUSION: Genetic polymorphism in DPYD seems to be
      associated with DFS in CRC patients receiving an adjuvant regimen of 5
      FU/capecitabine-based chemotherapy. Further studies are needed to verify these
      findings.

PMID- 29845394
TI  - Role of toll-like receptor 4 (TLR4)-mediated interleukin-6 (IL-6) production in
      chemotherapy-induced mucositis.
AB  - Despite significant advances in our ability to treat cancer, cytotoxic
      chemotherapy continues to be the mainstay treatment for many solid tumours.
      Chemotherapy is commonly associated with a raft of largely manageable adverse
      events; however, gastrointestinal (GI) toxicity (also termed mucositis) remains a
      significant challenge with little in the way of preventative and therapeutic
      options. The inability to manage GI complications likely reflects our incomplete
      understanding of its aetiology and the idiosyncrasies of each chemotherapeutic
      agent. This review highlights aims to provide a narrative for the involvement of
      Toll-like receptor (TLR4) in the development of chemotherapy-induced GI
      mucositis, an already emerging theme within this field. Particular focus will be
      placed upon the signalling interaction between TLR4 and interleukin (IL)-6. This
      parallels recent preclinical findings showing that TLR4 knockout mice, which are
      protected from developing severe GI mucositis, completely lack an IL-6 response.
      As such, we suggest that this signalling pathway presents as a novel mechanism
      with potential for therapeutic intervention.

PMID- 29845395
TI  - Assessment of trace element contamination of urban surface soil at informal
      industrial sites in a low-income country.
AB  - Trace elements released by human activity are ubiquitously detected in surface
      soil. The trace element contamination statuses of 20 sampling stations at two
      busy informal industrial sites of Harare city, Zimbabwe, were evaluated using
      geochemical indices. Spectrophotometric determinations of concentrations of trace
      elements in surface soil indicated generally higher values than the reference
      site and the average upper earth's crust. High contamination factors were
      observed for trace elements across sampling stations at Gazaland and Siyaso
      informal industrial sites. Concentrations exhibited heterogeneous distribution of
      trace elements in surface soil varying with the nature of activity at a sampling
      station. The pollution load index and degree of contamination suggested highly
      contaminated surface soil with Cd, Cu and Pb particularly where the following
      activities were done: (1) welding, (2) automobile maintenance and (3) waste
      dumping. These results may be very important to reduce soil contamination. Paving
      surfaces may help to reduce dispersal of trace elements deposited on surface soil
      to other stations and minimise human exposure via inhalation and contact.

PMID- 29845396
TI  - A predictive model for patients with median arcuate ligament syndrome.
AB  - BACKGROUND: Due to the rarity of median arcuate ligament (MAL) syndrome, patient
      selection for surgery remains difficult. This study provides a predictive model
      to optimize patient selection and predict outcomes following a MAL release.
      METHODS: Prospective data from patients undergoing a MAL release included
      demographics, radiologic studies, and SF-36 questionnaires. Successful
      postoperative changes in SF-36 was defined as an improvement > 10% in the total
      SF-36 score. A logistic regression model was used to develop a clinically
      applicable table to predict surgical outcomes. Celiac artery (CA) blood flow
      velocities were compared pre- and postoperatively and Pearson correlations were
      examined between velocities and SF-36 score changes. RESULTS: 42 patients
      underwent a laparoscopic MAL release with a mean follow-up of 28.5 +/- 18.8
      months. Postoperatively, all eight SF-36 scales improved significantly. The
      logistic regression model for predicting surgical benefit was significant (p =
      0.0244) with a strong association between predictors and outcome (R2 = 0.36). Age
      and baseline CA expiratory velocity were significant predictors of improvement
      and predicted clinical improvement. There were significant differences between
      pre- and postoperative CA velocities. Postoperatively, the bodily pain scale
      showed the most significant increase (64%, p < 0.0001). A table was developed
      using age and preoperative CA expiratory velocities to predict clinical outcomes.
      CONCLUSIONS: Laparoscopic MAL produces significant symptom improvement,
      particularly in bodily pain. This is one of the first studies that uses
      preoperative data to predict symptom improvement following a MAL release. Age and
      baseline CA expiratory velocity can be used to guide postoperative expectations
      in patients with MAL syndrome.

PMID- 29845397
TI  - SAGES review of endoscopic and minimally invasive bariatric interventions: a
      review of endoscopic and non-surgical bariatric interventions.
AB  - BACKGROUND: With obesity continuing as a global epidemic and therapeutic
      technologies advancing, several novel endoscopic and minimally invasive
      interventions will likely become available as treatment options. With improved
      technologies and different treatment strategies, as well as different patient
      populations being targeted, there will be greater application in the treatment
      armamentarium of specialists dedicated to treating obesity. We sought to review
      the existing technology and provide a review. METHODS: Literature review was
      carried out for endoscopic and minimally invasive devices. Some of these products
      are not FDA approved, so limited data are available in their review. RESULTS: A
      summary of the device and data currently available on weight loss and safety
      profile is provided. Several products are in clinical trials or will be soon.
      Some of the technology has limited data and companies will be submitting their
      results for FDA evaluation. CONCLUSIONS: The obesity epidemic and associated
      weight-related diseases represent a tremendous burden to health care
      practitioners. As such, a multi-modal and progressive approach, with data and
      outcomes examined, is likely the best and most comprehensive method to care for
      these patients. SAGES endorses the benefits of minimally invasive and endoscopic
      approaches in the treatment of obesity and its related co-morbidities.

PMID- 29845398
TI  - Clinicopathological significance of cancer stem cell markers CD44 and ALDH1
      expression in breast cancer.
AB  - BACKGROUND: CD44 and aldehyde dehydrogenase 1 (ALDH1) has been reputed to be
      cancer stem cell (CSC) markers in breast cancer. Yet, the clinicopathologic and
      prognostic significance of these markers remain unclear. In this study, we have
      investigated the expression of these markers and their relation with conventional
      clinicopathologic tumor characteristic including molecular subtype. METHODS: CD44
      and ALDH1 expression were investigated by immunohistochemistry in a series of 157
      formalin-fixed paraffin-embedded breast cancer tissues. RESULTS: Overall, CD44
      and ALDH1 are, respectively, detected in 33% (52 of 157) and 7% (10 of 157) of
      breast cancer cases. We also observed that CD44 expression was associated with
      histological grade (p = 0.005). For ALDH1, we found that its expression is more
      frequent with elderly women (> 50 years, p = 0.03). The investigation of
      relationship between the stem cell phenotype and breast cancer molecular subtype,
      revealed that CD44 and ALDH1 expression was more frequent in basal-like tumors (p
      = 0.005). Among the two cancer stem cell markers tested, ALDH1 showed a strong
      association with the basal marker EGFR (p = 0.05). CONCLUSIONS: These findings
      suggest that CD44 and ALDH1 play a role in the clinical behavior in breast cancer
      and might be interesting biomarkers and therapeutic targets.

PMID- 29845399
TI  - Patient-centric design of long-term care networks.
AB  - Long-term care networks may soon buckle under the weight of overwhelming demand.
      We present two dynamic, large-scale mixed-integer programs for long-term care
      network design that execute jointly strategic and tactical facility location,
      modular capacity acquisition, and patient-assignment decisions. The first model
      is an adaptive network-design model whose focus is more strategic in nature,
      whereas the second model focuses exclusively on the expansion of an existing long
      term care network and incorporates additional tactical decisions such as patient
      backlogs. Working directly with the president of the Order of Quebec Nurses-the
      provincial organization representing over 75,000 nurses-we incorporate facets
      such as assignment permanence, as well as develop and measure patient-centric
      quality-of-life proxies such as geographic mis-assignment and un-assigned
      patients, the latter of which is quantified via parametric optimization. Various
      network-design and patient-assignment policies are explored. We conclude that the
      use of home care as an alternative to long-term care facilities is cost
      prohibitive under specific conditions. Employing a bisection algorithm, we
      identify the implicit cost placed on keeping medically stable elderly patients in
      a hospital ward, concluding no cost savings are generated from such a policy. The
      model is analyzed and validated using empirical data from the long-term care
      network in Montreal, Canada.

PMID- 29845400
TI  - Exploring Factors Affecting Voluntary Adoption of Electronic Medical Records
      Among Physicians and Clinical Assistants of Small or Solo Private General
      Practice Clinics.
AB  - The health care reform initiative led by the Hong Kong government's Food and
      Health Bureau has started the implementation of an electronic sharing platform to
      provide an information infrastructure that enables public hospitals and private
      clinics to share their electronic medical records (EMRs) for improved access to
      patients' health care information. However, previous attempts to convince the
      private clinics to adopt EMRs to document health information have faced
      challenges, as the EMR adoption has been voluntary. The lack of electronic data
      shared by private clinics carries direct impacts to the efficacy of electronic
      record sharing between public and private healthcare providers. To increase the
      likelihood of buy-in, it is essential to proactively identify the users' and
      organizations' needs and capabilities before large-scale implementation. As part
      of the reform initiative, this study examined factors affecting the adoption of
      EMRs in small or solo private general practice clinics, by analyzing the
      experiences and opinions of the physicians and clinical assistants during the
      pilot implementation of the technology, with the purpose to learn from it before
      full-scale rollout. In-depth, semistructured interviews were conducted with 23
      physicians and clinical assistants from seven small or solo private general
      practice clinics to evaluate their experiences, expectations, and opinions
      regarding the deployment of EMRs. Interview transcripts were content analyzed to
      identify key factors. Factors affecting the adoption of EMRs to record and manage
      health care information were identified as follows: system interface design;
      system functions; stability and reliability of hardware, software, and computing
      networks; financial and time costs; task and outcome performance, work practice,
      and clinical workflow; physical space in clinics; trust in technology; users'
      information technology literacy; training and technical support; and social and
      organizational influences. The factors are interrelated with the others. The
      adoption factors identified are multifaceted, ranging from technological
      characteristics, clinician-technology interactions, skills and knowledge, and the
      user-workflow-technology fit. Other findings, which have been relatively
      underrepresented in previous studies, contribute unique insights about the
      influence of work and social environment on the adoption of EMRs, including
      limited clinic space and the effects of physicians' decision to use the
      technology on clinical staffs' adoption decisions. Potential strategies to
      address the concerns, overcome adoption barriers, and define relevant policies
      are discussed.

PMID- 29845401
TI  - The Impact of the Urban Neighborhood Environment on Marijuana Trajectories During
      Emerging Adulthood.
AB  - Although there is little difference in rates of marijuana use between White and
      Black youth, Blacks have significantly higher rates of marijuana use and disorder
      in young adulthood. Theory suggests that factors tied to social disadvantage may
      explain this disparity, and neighborhood setting may be a key exposure. This
      study sought to identify trajectories of marijuana use in an urban sample during
      emerging adulthood, neighborhood contexts that predict these trajectories and
      social role transitions or "turning points" that may redirect them. Data are from
      a longitudinal cohort study of 378 primarily Black emerging adults who were first
      sampled in childhood based on their residence in low-income neighborhoods in
      Baltimore City and followed up annually. Group-based trajectory modeling
      identified three groups: No Use (68.8%), Declining Use (19.6%), and Chronic Use
      (11.7%). Living in close proximity to an alcohol outlet, and living in a
      neighborhood with more female-headed households and higher rates of violent crime
      increased the odds of membership in the Chronic Use group relative to No Use.
      Living in a neighborhood with more positive social activity increased the odds of
      membership in the Declining Use group relative to No Use. Not receiving a high
      school diploma or GED, pregnancy, and parenting also increased the odds of
      membership in the Declining Use group relative to No Use. These findings provide
      support that minority youth living in socially toxic and disordered neighborhoods
      are at increased risk of continuing on a trajectory of marijuana use during
      emerging adulthood while positive social activity in neighborhoods has the
      potential to redirect these negative trajectories. Besides taking on the
      responsibilities of parenting, emerging adults in the marijuana user groups had
      similar educational and family outcomes, suggesting that early marijuana use may
      have long-term implications.

PMID- 29845402
TI  - Clinical study on natural gingival color.
AB  - The aims of the study were: to describe the gingival color surrounding the upper
      incisors in three sites in the keratinized gingiva, analyzing the effect of
      possible factors which modulate (socio-demographic and behavioral) intersubject
      variability; to study whether the gingiva color is the same in all three
      locations and to describe intrasubject color differences in the keratinized
      gingiva band. Using the CIELAB color system, three reference areas (free gingival
      margin, keratinized gingival body, and birth or upper part of the keratinized
      gingiva) were studied in 259 individuals, as well as the related socio
      demographic factors, oral habits and the chronic intake of medication.
      ShadepilotTM spectrophotometer was used. Descriptive and inferential statistical
      analysis was performed. There are statistically significant differences between
      males and females for coordinates L* and a* in the middle and free gingival
      margin. For the b* coordinate, there are differences between males and females in
      the three locations studied (p < 0.05). The minimum and maximum coordinates in
      which the CIELAB natural gingival space is delimited are L* minima 28.3, L*
      maximum 65.4, a* minimum 11.1, a* maximum 37.2, b* minimum 6.9, and b* maximum
      25.2*. Age, smoking, and the chronic intake of medication had no significant
      effect on gum color. There are perceptible color differences within the
      keratinized gingiva band. These chromatic differences must be taken into account
      if the prosthetic characterization of gingival tissue is to be considered
      acceptable. There are significant differences between the color coordinates of
      the three sites studied in the keratinized gingiva of men and women.

PMID- 29845403
TI  - Applications of Advanced Breast Imaging Modalities.
AB  - PURPOSE OF REVIEW: Advanced mammographic imaging modalities have been implemented
      in clinical practices throughout the USA. The most notable and widely used has
      been the three-dimensional derivative of digital mammography, known as digital
      breast tomosynthesis (DBT). In this article, we review the screening and
      diagnostic applications of DBT, along with its limitations. We also briefly
      address several supplemental breast imaging modalities. RECENT FINDINGS: The
      accumulating evidence from both small and large-scale trials has shown a
      significant reduction in recall rates and slight increase in cancer detection
      rates when using DBT. However, the incremental increase in cancers detected
      remains less than that achieved with several supplemental imaging modalities,
      including whole-breast ultrasound, MRI, and MBI (molecular breast imaging). Other
      modalities, such as CEM (contrast-enhanced mammography) and CET (contrast
      enhanced tomography), are also being investigated. Numerous studies have
      confirmed the added value of DBT and its increased cancer detection rate in both
      the screening and diagnostic settings. However, the superior sensitivity of
      supplemental imaging modalities renders them essential, especially in high-risk
      patients, and potentially those with dense breasts.

PMID- 29845404
TI  - Asthma, Environment and Pollution: Where the Rubber Hits the Road.
AB  - The detrimental effects of environmental pollution on one's health are undeniable
      and have been demonstrated time and time again. Breathing in pollutants in
      ambient air often has consequences throughout the body, including cardiovascular
      disease, effects on the reproductive system, and oncologic implications. In the
      respiratory system, chronic exposure yields a number of outcomes, including
      chronic obstructive pulmonary disease (COPD) and asthma exacerbations, increased
      rates of hospitalizations, and increased severity of acute illnesses. On a macro
      level, this morbidity and mortality then leads to vast and far-reaching public
      health consequences the world over, including the loss of billions of dollars'
      worth of labor. This is especially applicable in developing countries, which
      often undergo rapid growth, industrialization and urbanization with a resultant
      increase in vehicular traffic, coal combustion, and fuel emissions as a whole.
      For this reason, environmental pollutants have been studied extensively, and
      countries around the globe have established laws that regulate ambient air levels
      of so-called criteria pollutants. This article will explore several of these
      criteria pollutants, including particulate matter, nitrogen dioxide, sulfur
      dioxide, and ozone, and their individual relationships to asthma pathophysiology.
      However, it is also emphasized that though each one of these toxins yields its
      own effects, the group of them often works together to have cumulative
      consequences. For these reasons and many more, it is important to remain aware
      and educated about these omnipresent environmental pollutants.

PMID- 29845405
TI  - Future Treatment Strategy for Esophageal Cancer Based on Prediction of Systemic
      Recurrence: Significance of Pathologic Nodal Status After Neoadjuvant
      Chemotherapy.

PMID- 29845406
TI  - Central Lymph Node Status has Significant Prognostic Value in the Clinically Node
      Negative Tall-Cell Variant of Papillary Thyroid Cancer Regardless of T-Staging
      and Radioactive Iodine Administration: First Evidence From a Population-Based
      Study.
AB  - BACKGROUND: The prognostic value of central lymph node (CLN) status in papillary
      thyroid cancer (PTC) remains controversial. This study aimed to provide the first
      evidence on this issue for the aggressive tall-cell variant (TCV) subtype.
      METHODS: The study identified TCV patients from the Surveillance, Epidemiology,
      and End Results database. The Kaplan-Meier method, log-rank test, and
      multivariate Cox regression models were used for analysis. RESULTS: Of the 744
      patients included, 404 were recorded as N0, which were pathologically or only
      clinically confirmed. Overall survival (OS) and cancer-specific survival (CSS)
      did not differ significantly between the N0 and pN1a patients (p > 0.05). To
      investigate the reason, the N0 patients were subdivided according to the number
      of examined lymph nodes (ELN). The patients with a N0 diagnosis confirmed by two
      or more ELNs (N0-e2+) showed significantly better outcomes than the pN1a patients
      and their N0 counterparts without ELN (N0-e0) (p < 0.05), whereas the N0-e0 and
      pN1a groups demonstrated comparable outcomes in both the log-rank and
      multivariate analyses (p > 0.05). Moreover, the subgroup analyses showed that
      even among the patients with early T-staging (T1-T2) or receipt of radioactive
      iodine (RAI) therapy, the N0-e0 patients still demonstrated compromised OS
      compared with the N0-e2+ group (p < 0.05). CONCLUSION: The cN0 patients without
      ELN (N0-e0) had outcomes similar to those of the pN1a patients, but showed a
      poorer OS than the N0-e2+ group regardless of T-staging and RAI administration,
      suggesting that occult CLN metastases might act as a negative prognosticator in
      cN0 TCV. Therefore, prophylactic central neck dissection might be considered for
      biopsy-proven cN0 TCV patients. Prospective studies are expected to further
      validate our conclusions.

PMID- 29845407
TI  - Fractures of hamate: a clinical overview.
AB  - Hamate fractures are exceedingly rare clinical entities. However, the diagnosis
      and treatment of these injuries are often delayed and can severely handicap the
      performance of affected laborers or athletes. This review focuses on fractures of
      the hamate and provides an update on the current consensus as to mechanism,
      diagnosis, management, and complications after such injuries.

PMID- 29845409
TI  - C-X-C Motif Chemokine 12 Enhances Lipopolysaccharide-Induced Osteoclastogenesis
      and Bone Resorption In Vivo.
AB  - C-X-C motif chemokine 12 (CXCL12) belongs to the family of CXC chemokines.
      Lipopolysaccharide (LPS) induces inflammation-induced osteoclastogenesis and bone
      resorption, and in recent years, stimulatory effects of CXCL12 on bone resorption
      have also been reported. In the present study, we investigated the effects of
      CXCL12 on LPS-induced osteoclastogenesis and bone resorption. LPS was
      administered with or without CXCL12 onto mouse calvariae by daily subcutaneous
      injection. Numbers of osteoclasts and bone resorption were significantly elevated
      in mice co-administered LPS and CXCL12 compared with mice administered LPS alone.
      Moreover, receptor activator of NF-kB ligand (RANKL) and tumor necrosis factor
      alpha (TNF-alpha) mRNA levels were higher in mice co-administered LPS and CXCL12
      compared with mice administered LPS alone. These in vitro results confirmed a
      direct stimulatory effect of CXCL12 on RANKL- and TNF-alpha-induced
      osteoclastogenesis. Furthermore, TNF-alpha and RANKL mRNA levels were elevated in
      macrophages and osteoblasts, respectively, co-treated in vitro with CXCL12 and
      LPS, in comparison with cells treated with LPS alone. Our results suggest that
      CXCL12 enhances LPS-induced osteoclastogenesis and bone resorption in vivo
      through a combination of increasing LPS-induced TNF-alpha production by
      macrophages, increasing RANKL production by osteoblasts, and direct enhancement
      of osteoclastogenesis.

PMID- 29845408
TI  - Is there a role for immunotherapy in malignant pleural mesothelioma?
AB  - Malignant pleural mesothelioma (MPM) is a very aggressive malignancy, mainly
      caused by asbestos exposure. Patients with MPM have a poor prognosis that
      remained substantially unchanged in the last few years and limited effective
      therapeutic options with no recognized second or further-line therapy. In this
      context, also in view of the positive results observed in other tumor types,
      immunotherapy could play a relevant role. This review focuses on the most
      promising immunotherapies being investigated in MPM.

PMID- 29845410
TI  - Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone
      Volume.
AB  - Dickkopf-1 (DKK1) and sclerostin are antagonists of the Wnt/beta-catenin pathway
      and decreased expression of either results in increased bone formation and mass.
      As both affect the same signaling pathway, we aimed to elucidate the redundancy
      and/or compensation of sclerostin and DKK1. Weekly sclerostin antibody (Scl-Ab)
      was used to treat 9-week-old female Dkk1 KO (Dkk1-/-:Wnt3+/-) mice and compared
      to Scl-Ab-treated wild-type mice as well as vehicle-treated Dkk1 KO and wild-type
      animals. While Wnt3 heterozygote (Wnt3+/-) mice show no bone phenotype, Scl-Ab
      and vehicle-treated control groups of this genotype were included. Specimens were
      harvested after 3 weeks for microCT, bone histomorphometry, anti-sclerostin
      immunohistochemistry, and biomechanical testing. Scl-Ab enhanced bone anabolism
      in all treatment groups, but with synergistic enhancement seen in the cancellous
      compartment of Dkk1 KO mice (bone volume + 55% Dkk1 KO p < 0.01; + 22% wild type
      p < 0.05). Scl-Ab treatment produced less marked increases in cortical bone of
      the tibiae, with anabolic effects similar across genotypes. Mechanical testing
      confirmed that Scl-Ab improved strength across all genotypes; however, no
      enhancement was seen within Dkk1 KO mice. Dynamic bone labeling showed that Scl
      Ab treatment was associated with increased bone formation, regardless of
      genotype. Immunohistochemical staining for sclerostin protein indicated no
      differences in the Dkk1 KO mice, indicating that the increased Wnt signaling
      associated with DKK1 deficiency was not compensated by upregulation of sclerostin
      protein. These data suggest complex interactions between Wnt signaling factors in
      bone, but critically illustrate synergy between DKK1 deficiency and Scl-Ab
      treatment. These data support the application of dual-targeted therapeutics in
      the modulation of bone anabolism.

PMID- 29845411
TI  - Eye Movements Evoked by Pulsed Infrared Radiation of the Rat Vestibular System.
AB  - Light at infrared wavelengths has been demonstrated to modulate the pattern of
      neural signals transmitted from the angular motion sensing semicircular canals of
      the vestibular system to the brain. In the present study, we have characterized
      physiological eye movements evoked by focused, pulsed infrared radiation (IR)
      stimuli directed at an individual semicircular canal in a mammalian model. Pulsed
      IR (1863 nm) trains were directed at the posterior semicircular canal in a rat
      using 200-400 um optical fibers. Evoked bilateral eye movements were measured
      using a custom-modified video-oculography system. The activation of vestibulo
      ocular motor pathways by frequency modulated pulsed IR directed at single
      posterior semicircular canals evoked significant, characteristic bilateral eye
      movements. In this case, the resulting eye movements were disconjugate with
      ipsilateral eye moving upwards with a rotation towards the stimulated ear and the
      contralateral eye moving downwards. The eye movements were stable through several
      hours of repeated stimulation and could be maintained with 30 + minutes of
      continuous, frequency-modulated IR stimulation. Following the measurements, the
      distance of the fiber from target structures and orientation of the beam relative
      to vestibular structures were determined using micro-computed tomography. Results
      highlight the spatial selectivity of optical stimulation. Our results demonstrate
      a novel strategy for direct optical stimulation of the vestibular pathway in
      rodents and lays the groundwork for future applications of optical neural
      stimulation in inner ear research and therapeutic applications.

PMID- 29845412
TI  - Triple-Layer Vascular Grafts Fabricated by Combined E-Jet 3D Printing and
      Electrospinning.
AB  - Small-diameter tissue-engineered vascular grafts are urgently needed for clinic
      arterial substitute. To simulate the structures and functions of natural blood
      vessels, we designed a novel triple-layer poly(epsilon-caprolactone) (PCL)
      fibrous vascular graft by combining E-jet 3D printing and electrospinning
      techniques. The resultant vascular graft consisted of an interior layer
      comprising 3D-printed highly aligned strong fibers, a middle layer made by
      electrospun densely fibers, and an exterior structure composed of mixed fibers
      fabricated by co-electrospraying. The biocompatible triple-layer graft was used
      for in vivo implantation, and results demonstrated that the longitudinally
      aligned fibers within the lumen of the graft could enhance the proliferation and
      migration of endothelial cells, while maintained good mechanical properties. The
      exterior layer provided a pathway that encouraged cells to migrate into the
      scaffold after implantation. This experimental graft overcame the limitations of
      conventionally electrospun vascular grafts of inadequate porosity and lowly cell
      penetration. The unique structure of the triple-layer vascular graft promoted
      cell growth and infiltration in vivo, thus provided an encouraging substitute for
      in situ tissue engineering.

PMID- 29845413
TI  - Automatic Robotic Steering of Flexible Needles from 3D Ultrasound Images in
      Phantoms and Ex Vivo Biological Tissue.
AB  - Robotic control of needle bending aims at increasing the precision of
      percutaneous procedures. Ultrasound feedback is preferable for its clinical ease
      of use, cost and compactness but raises needle detection issues. In this paper,
      we propose a complete system dedicated to robotized guidance of a flexible needle
      under 3D ultrasound imaging. This system includes a medical robot dedicated to
      transperineal needle positioning and insertion, a rapid path planning for needle
      steering using bevel-tip needle natural curvature in tissue, and an ultrasound
      based automatic needle detection algorithm. Since ultrasound-based automatic
      needle steering is often made difficult by the needle localization in biological
      tissue, we quantify the benefit of using flexible echogenic needles for robotized
      guidance under 3D ultrasound. The "echogenic" term refers to the etching of
      microstructures on the needle shaft. We prove that these structures improve
      needle visibility and detection robustness in ultrasound images. We finally
      present promising results when reaching targets using needle steering. The
      experiments were conducted with various needles in different media (synthetic
      phantoms and ex vivo biological tissue). For instance, with nitinol needles the
      mean accuracy is 1.2 mm (respectively 3.8 mm) in phantoms (resp. biological
      tissue).

PMID- 29845414
TI  - Avian malaria co-infections confound infectivity and vector competence assays of
      Plasmodium homopolare.
AB  - Currently, there are very few studies of avian malaria that investigate
      relationships among the host-vector-parasite triad concomitantly. In the current
      study, we experimentally measured the vector competence of several Culex
      mosquitoes for a newly described avian malaria parasite, Plasmodium homopolare.
      Song sparrow (Melospiza melodia) blood infected with a low P. homopolare
      parasitemia was inoculated into a naive domestic canary (Serinus canaria forma
      domestica). Within 5 to 10 days post infection (dpi), the canary unexpectedly
      developed a simultaneous high parasitemic infection of Plasmodium cathemerium
      (Pcat6) and a low parasitemic infection of P. homopolare, both of which were
      detected in blood smears. During this infection period, PCR detected Pcat6, but
      not P. homopolare in the canary. Between 10 and 60 dpi, Pcat6 blood stages were
      no longer visible and PCR no longer amplified Pcat6 parasite DNA from canary
      blood. However, P. homopolare blood stages remained visible, albeit still at very
      low parasitemias, and PCR was able to amplify P. homopolare DNA. This pattern of
      mixed Pcat6 and P. homopolare infection was repeated in three secondary infected
      canaries that were injected with blood from the first infected canary. Mosquitoes
      that blood-fed on the secondary infected canaries developed infections with Pcat6
      as well as another P. cathemerium lineage (Pcat8); none developed PCR detectable
      P. homopolare infections. These observations suggest that the original P.
      homopolare-infected songbird also had two un-detectable P. cathemerium
      lineages/strains. The vector and host infectivity trials in this study
      demonstrated that current molecular assays may significantly underreport the
      extent of mixed avian malaria infections in vectors and hosts.

PMID- 29845416
TI  - Brief communication: use of the minimal important difference for a meta-analysis
      on exercise and anxiety in adults with arthritis.
AB  - A recent meta-analysis reported statistically significant improvements in anxiety
      as a result of exercise in adults with arthritis and other rheumatic diseases
      (AORD) using the traditional standardized mean difference (SMD) effect size (ES).
      The objective of this study was to use the more recently developed and clinically
      relevant minimal important difference (MID) approach to examine this association.
      Data from a previous meta-analysis of 14 randomized controlled trials
      representing 926 initially enrolled adults >= 18 years of age (539 exercise, 387
      control) was used to calculate the ES using the MID approach. Minimal important
      difference data were derived from previously reported anchor-based values that
      represented the different instruments used to assess anxiety. Effect sizes were
      pooled using the inverse heterogeneity (IVhet) model. Overall, exercise resulted
      in a mean ES reduction in anxiety of - 0.80 (95% CI, - 1.60 to 0.001, p = 0.05; Q
      = 92.1, p < 0.001, I 2  = 83.7%, 95% CI, 74.9%, 89.5%), suggesting that overall,
      exercise may benefit an appreciable number of patients. Nonetheless, this effect
      spanned the range from many patients gaining important benefits to no patients
      improving. The clinically relevant effects of exercise on anxiety in adults with
      AORD are varied. However, these results should be interpreted with caution given
      the absence of anchor-based MID data specific to the instruments and questions
      used to assess anxiety in adults with AORD. A need exists for future research to
      establish instrument-specific, anchor-based MID values for questions assessing
      anxiety in adults with AORD.

PMID- 29845415
TI  - A lentiviral vaccine expressing KMP11-HASPB fusion protein increases immune
      response to Leishmania major in BALB/C.
AB  - Hydrophilic acylated surface protein B (HASPB) is an immunogenic Leishmania
      specific protein that antibodies are produced against it in the sera of
      Leishmania-infected individuals. Kinetoplastid membrane protein 11 (KMP11) is
      another Leishmania antigen and considered as the suitable candidate for vaccine
      development Leishmaniasis. It is a highly conserved surface protein expressed in
      both promastigotes and amastigotes. In this study, KMP11 and HASPB coding
      sequences were cloned into a pCDH-cGFP lentiviral vector as a fusion protein to
      be used as a DNA vaccine against L. major. The KMP11-HASPB fusion protein was
      successfully expressed as evidenced by RT-PCR and Western blot assays. The effect
      of the vaccine was determined by evaluating the level of IFN-gamma, IL-10, IgG1,
      and IgG2a performed using ELISA as well as determining the parasite load after
      challenge with L. major in vaccinated mice. The results revealed that IFN-gamma,
      IL-10, IgG1, and IgG2a significantly increased after vaccination using KMP11
      HASPB-expressing lentiviruses in BALB/c mice. It is noteworthy that the level of
      IFN-gamma and IgG2a was higher than that of IL-10 and IgG1, respectively, which
      indicates the activation Th1 cells, macrophages, and cellular immunity. Moreover,
      the parasite load in the spleen and lymph node of vaccinated mice after challenge
      was significantly lower than that of controls.

PMID- 29845417
TI  - Carotid and femoral Doppler do not allow the assessment of passive leg raising
      effects.
AB  - BACKGROUND: The hemodynamic effects of the passive leg raising (PLR) test must be
      assessed through a direct measurement of cardiac index (CI). We tested whether
      changes in Doppler common carotid blood flow (CBF) and common femoral artery
      blood flow (FBF) could detect a positive PLR test (increase in CI >= 10%). We
      also tested whether CBF and FBF changes could track simultaneous changes in CI
      during PLR and volume expansion. In 51 cases, we measured CI (PiCCO2), CBF and
      FBF before and during a PLR test (one performed for CBF and another for FBF
      measurements) and before and after volume expansion, which was performed if PLR
      was positive. RESULTS: Due to poor echogenicity or insufficient Doppler signal
      quality, CBF could be measured in 39 cases and FBF in only 14 cases. A positive
      PLR response could not be detected by changes in CBF, FBF, carotid nor by femoral
      peak systolic velocities (areas under the receiver operating characteristic
      curves: 0.58 +/- 0.10, 0.57 +/- 0.16, 0.56 +/- 0.09 and 0.64 +/- 10,
      respectively, all not different from 0.50). The correlations between simultaneous
      changes in CI and CBF and in CI and FBF during PLR and volume expansion were not
      significant (p = 0.41 and p = 0.27, respectively). CONCLUSION: Doppler
      measurements of CBF and of FBF, as well as measurements of their peak velocities,
      are not reliable to assess cardiac output and its changes.

PMID- 29845418
TI  - End-of-life chemotherapy is associated with poor survival and aggressive care in
      patients with small cell lung cancer.
AB  - BACKGROUND: Concerns regarding end-of-life (EOL) chemotherapy are being
      increasingly raised. Tumor chemosensitivity may influence the decision for
      aggressive chemotherapy near the EOL. Data on EOL chemotherapy in highly
      chemosensitive tumors, such as small cell lung cancer (SCLC), are scarce. METHOD:
      A total of 143 SCLC decedents were consecutively included. Data about clinical
      factors and treatment modalities were obtained from the electronic medical
      records. The relationships among EOL chemotherapy, clinical features, overall
      survival (OS), and aggressive care were investigated. RESULTS: About 64% of
      patients had chemosensitive disease. In total, 30.8 and 16.1% of patients
      received EOL chemotherapy within the last 1 and 2 months of life, respectively.
      Younger age was associated with a higher rate of EOL chemotherapy. We determined
      that EOL chemotherapy was related to inferior OS not only in the entire group,
      but also in the chemosensitive subgroup. Furthermore, more intensive care was
      observed among patients who underwent EOL chemotherapy compared with those who
      did not. CONCLUSIONS: EOL chemotherapy was correlated with shorter survival and
      more aggressive care in patients with SCLC. More research is needed to develop
      indications for terminating palliative chemotherapy, to help physicians and
      patients with their difficult choices.

PMID- 29845419
TI  - What deserves our respect? Reexamination of respect for autonomy in the context
      of the management of chronic conditions.
AB  - The global increase in patients with chronic conditions has led to increased
      interest in ethical issues regarding such conditions. A basic biomedical
      principle-respect for autonomy-is being reexamined more critically in its
      clinical implications. New accounts of this basic principle are being proposed.
      While new accounts of respect for autonomy do underpin the design of many public
      programs and policies worldwide, addressing both chronic disease management and
      health promotion, the risk of applying such new accounts to clinical setting
      remain understudied. However, the application of new accounts of respect for
      autonomy to clinical settings could support disrespectful attitudes toward or
      undue interference with patients with chronic conditions. Reconsidering autonomy
      and respect using Kantian accounts, this paper proposes respect for persons as an
      alternative basic bioethical principle to respect for autonomy. Unlike the
      principle of respect for persons in the Belmont Report, our principle involves
      respecting any patient's decisions, behaviors, emotions, or life-style regardless
      of his or her "autonomous" capabilities. Thus, attitudes toward patients should
      be no different irrespective of the assessment of their decisional or executive
      capabilities.

PMID- 29845420
TI  - Ongoing ostomy self-care challenges of long-term rectal cancer survivors.
AB  - PURPOSE: Surgical treatment for rectal cancer (RC) can result in an intestinal
      ostomy that requires lifelong adaptation and investment of physical, cognitive,
      and financial resources. However, little is known about the extent of ongoing
      challenges related to ostomy self-care among long-term RC survivors. We analyzed
      the prevalence of self-reported ostomy self-care challenges and the physical and
      environmental factors that can support or undermine ostomy self-care. METHODS: We
      mailed surveys to long-term (>= 5 years post-diagnosis) RC survivors, including
      177 adults with ostomies who were members of integrated health systems in
      northern California, Oregon, and Washington State. Potential participants were
      identified through tumor registries. Data were also extracted from electronic
      health records. RESULTS: The response rate was 65%. The majority of respondents
      were male (67%), and the mean age was 75 years. Sixty-three percent of
      respondents reported at least one ostomy self-care challenge. The most common
      challenges were leakage or skin problems around the ostomy and needing to change
      the pouching system too frequently. Twenty-two percent reported difficulty caring
      for their ostomy. Younger age and higher BMI were consistently related to ostomy
      self-care challenges. CONCLUSIONS: The majority of RC survivors reported ostomy
      related self-care challenges, and 31% experienced problems across multiple
      domains of ostomy self-care. In addition, most survivors reported significant
      physical challenges that could lead to ostomy-related disability. Although the
      participants surveyed had access to ostomy care nurses, the care gaps we found
      suggest that additional work is needed to understand barriers to ostomy care,
      reduce unmet needs, and improve well-being among this group.

PMID- 29845421
TI  - Return to work in European Cancer survivors: a systematic review.
AB  - PURPOSE: Return to work (RTW) of cancer survivors (CSs) fluctuates in different
      contexts. This systematic review searched for recent data on the RTW rate of CSs
      in Europe, investigating associated factors. METHODS: Bibliographic search
      covered the period from January 2010 to February 2018, with no language
      restrictions. European population-based studies assessing RTW rate after cancer
      diagnosis were included. We excluded studies focusing on a specific cancer
      diagnosis. RESULTS: Twelve observational studies were selected. The cohorts
      investigated included 280 to 46,720 individuals from Northwestern and Central
      Europe diagnosed with cancer from 1987 to 2010. The median interval between
      diagnosis and documented RTW was 2 years (0.2-23.4 years). RTW rates of CSs
      ranged from 39 to 77%. RTW of individuals employed at the time of diagnosis
      ranged from 60 to 92%, the latter registered in a sample with good prognosis.
      Personal factors, work-related factors, and cancer-related factors were all
      associated with RTW. Healthcare team interventions facilitated reintegration to
      work. CONCLUSIONS: Data from Mediterranean and Central European countries are
      urgently needed to understand whether RTW is an issue for CSs there as well and
      whether socio-rehabilitative interventions are required to mitigate the potential
      negative impact of cancer on individuals and society.

PMID- 29845422
TI  - Do drugs offering only PFS maintain quality of life sufficiently from a patient's
      perspective? Results from AVALPROFS (Assessing the 'VALue' to patients of
      PROgression Free Survival) study.
AB  - PURPOSE: Trials of novel drugs used in advanced disease often show only
      progression-free survival or modest overall survival benefits. Hypothetical
      studies suggest that stabilisation of metastatic disease and/or symptom burden
      are worth treatment-related side effects. We examined this premise
      contemporaneously using qualitative and quantitative methods. METHODS: Patients
      with metastatic cancers expected to live > 6 months and prescribed drugs aimed at
      cancer control were interviewed: at baseline, at 6 weeks, at progression, and if
      treatment was stopped for toxicity. They also completed Functional Assessment of
      Cancer Therapy (FACT-G) plus Anti-Angiogenesis (AA) subscale questionnaires at
      baseline then monthly for 6 months. RESULTS: Ninety out of 120 (75%) eligible
      patients participated: 41 (45%) remained on study for 6 months, 36 progressed or
      died, 4 had treatment breaks, and 9 withdrew due to toxicity. By 6 weeks, 66/69
      (96%) patients were experiencing side effects which impacted their activities.
      Low QoL scores at baseline did not predict a higher risk of death or dropout. At
      6-week interviews, as the side effect severity increased, patients were
      significantly less inclined to view the benefit of cancer control as worthwhile
      (X2 = 50.7, P < 0.001). Emotional well-being initially improved from baseline by
      10 weeks, then gradually returned to baseline levels. CONCLUSION: Maintaining QoL
      is vital to most patients with advanced cancer so minimising treatment-related
      side effects is essential. As side effect severity increased, drugs that
      controlled cancer for short periods were not viewed as worthwhile. Patients need
      to have the therapeutic aims of further anti-cancer treatment explained honestly
      and sensitively.

PMID- 29845423
TI  - G6PD as a predictive marker for glioma risk, prognosis and chemosensitivity.
AB  - PURPOSE: Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme preventing
      cells from oxidative damage and has been reported to have tumor-promoting roles.
      This study aims to comprehensively evaluate the predictive values of G6PD on
      brain tumor risk, prognosis and chemo-resistance. METHODS: A retrospective 13
      year cohort study analyzing cancer risk using the Taiwan National Health
      Insurance Research Database (4066 G6PD deficiency patients and 16,264 controls)
      was conducted. Furthermore, RNAseq and clinical data of grade II-III glioma (LGG,
      n = 515) and glioblastoma (GBM, n = 155) were downloaded from The Cancer Genome
      Atlas (TCGA) and analyzed. Bioinformatics methods were applied to build a glioma
      prognostication model and to predict response to chemotherapy based on tumor G6PD
      related gene expressions. The predicted results were validated in another glioma
      cohort GSE 16011 and in KALS1 cell line. RESULTS: G6PD-dificient patients were
      found to have an increased risk for cancers, especially for brain tumor (adjusted
      hazard ratio (HR) 10.5, 95% CI 1.03-7.60). Furthermore, higher tumor G6PD
      expression was associated with poor patient survival in LGG, but not in GBM. A
      prognostication model using expression levels of G6PD and 9 related genes (PSMA2,
      PSMB8, SHFM1, GSS, GSTK1, MGST2, POLD3, MSH2, MSH6) could independently predict
      LGG patient survival. Boosted decision tree analysis on 213 cancer cell line
      database revealed predictive values of G6PD expression on response to gemcitabine
      and bortezomib. Knockdown of G6PD in KALS1 cell line enhanced its sensitivity to
      both chemotherapeutic agents. CONCLUSIONS: Our study suggests that G6PD could be
      a marker predicting glioma risk, prognosis and chemo-sensitivity.

PMID- 29845424
TI  - The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival
      of renal carcinoma cells.
AB  - Novel therapies are required for the treatment of metastatic renal cell carcinoma
      (RCC), which is associated with inoperable disease and patient death. Histone
      deacetylases (HDACs) are epigenetic modifiers and potential drug targets.
      Additional information on molecular pathways that are altered by histone
      deacetylase inhibitors (HDACi) in RCC cells is warranted. It should equally be
      delineated further which individual members of the 18 mammalian HDACs determine
      the survival and tumor-associated gene expression programs of such cells. Most
      importantly, an ongoing dispute whether HDACi promote or suppress metastasis
      associated epithelial-to-mesenchymal transition (EMT) has to be resolved before
      HDACi are considered further as clinically relevant drugs. Here we show how HDACi
      affect murine and primary human RCC cells. We find that these agents induce
      morphological alterations resembling the metastasis-associated EMT. However,
      individual and proteomics-based analyses of epithelial and mesenchymal marker
      proteins and of EMT-associated transcription factors (EMT-TFs) reveal that HDACi
      do not trigger EMT. Pathway deconvolution analysis identifies reduced
      proliferation and apoptosis induction as key effects of HDACi. Furthermore, these
      drugs lead to a reduction of the cell adhesion molecule E-cadherin and of the
      platelet-derived growth factor receptor-beta (PDGFRbeta), which is a key driver
      of RCC metastasis formation. Accordingly, HDACi reduce the pulmonary spread of
      syngeneic transplanted renal carcinoma cells in mice. Specific genetic
      elimination of the histone deacetylases HDAC1/HDAC2 reflects the effects of
      pharmacological HDAC inhibition regarding growth suppression, apoptosis, and the
      downregulation of E-cadherin and PDGFRbeta. Thus, these epigenetic modifiers are
      non-redundant gatekeepers of cell fate and precise pharmacological targets.

PMID- 29845425
TI  - A Novel PET Probe "[18F]DiFA" Accumulates in Hypoxic Region via Glutathione
      Conjugation Following Reductive Metabolism.
AB  - PURPOSE: Hypoxia in tumor has close relationship with angiogenesis and tumor
      progression. Previously, we developed 2,2-dihydroxymethyl-3-[18F]fluoropropyl-2
      nitroimidazole ([18F]DiFA) as a novel positron emission tomography (PET) probe
      for diagnosis of hypoxia. In this study, we elucidated whether the accumulation
      of [18F]DiFA in cells is dependent on the hypoxic state and revealed how
      [18F]DiFA accumulates in hypoxic cells in combination with imaging mass
      spectrometry (IMS). PROCEDURES: FaDu human head and neck cancer cells were
      treated with [18F]DiFA and then incubated under normoxia (21% O2) or hypoxia (1%
      O2) for 2 h. The cells were extracted using methanol, and the radioactivities of
      the precipitates (macromolecule fraction) and supernatants (low-molecular-weight
      fraction) were measured. FaDu-bearing mice were injected intravenously with
      [18F]DiFA and with pimonidazole 1 h later. The tumors were excised 2 h after the
      injection of [18F]DiFA. Autoradiography, IMS, and immunohistochemical (IHC)
      staining for pimonidazole were performed with serial tumor sections. RESULTS: In
      the in vitro study, the radioactivity of FaDu cells was significantly higher
      under hypoxia than that under normoxia (0.53 +/- 0.02 vs. 0.27 +/- 0.02 %dose/mg
      protein, p < 0.05). The radioactivity of the low-molecular-weight fraction was
      66.3 +/- 0.6% in the hypoxic cell. In the in vivo study, [18F]DiFA accumulated in
      the tumor tissues existed mainly as low-molecular-weight compounds (90.4 +/-
      0.9%). In addition, the glutathione conjugate of reductive DiFA metabolite (amino
      DiFA-GS) existed in tumor tissues revealed by the IMS study, and the distribution
      pattern of amino-DiFA-GS was very similar to that of the radioactivity and the
      positive staining area of pimonidazole. CONCLUSIONS: Our results suggest that
      [18F]DiFA undergoes the glutathione conjugation reaction following reductive
      metabolism in hypoxic cells, which leads hypoxia-specific PET imaging with
      [18F]DiFA.

PMID- 29845426
TI  - Influence of Dexamethasone on O-(2-[18F]-Fluoroethyl)-L-Tyrosine Uptake in the
      Human Brain and Quantification of Tumor Uptake.
AB  - PURPOSE: O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) is an established positron
      emission tomography (PET) tracer for brain tumor imaging. This study explores the
      influence of dexamethasone therapy on [18F]FET uptake in the normal brain and its
      influence on the maximum and mean tumor-to-brain ratio (TBR). PROCEDURES:
      [18F]FET PET scans of 160 brain tumor patients were evaluated (80 dexamethasone
      treated, 80 untreated; each group with 40 men/40 women). The standardized uptake
      value of [18F]FET uptake in the normal brain (SUVbrain) in the different groups
      was compared. Nine patients were examined repeatedly with and without
      dexamethasone therapy. RESULTS: SUVbrain of [18F]FET uptake was significantly
      higher in dexamethasone-treated patients than in untreated patients (SUVbrain
      1.33 +/- 0.1 versus 1.06 +/- 0.16 in male and 1.45 +/- 0.25 versus 1.31 +/- 0.28
      in female patients). Similar results were observed in patients with serial PET
      scans. Furthermore, compared to men, a significantly higher SUVbrain was found in
      women, both with and without dexamethasone treatment. There were no significant
      differences between the different groups for TBRmax and TBRmean, which could have
      been masked by the high standard deviation. In a patient with a stable brain
      metastasis investigated twice with and without dexamethasone, the TBRmax and the
      biological tumor volume (BTV) decreased considerably after dexamethasone due to
      an increased SUVbrain. CONCLUSION: Dexamethasone treatment appears to increase
      the [18F]FET uptake in the normal brain. An effect on TBRmax, TBRmean, and BTV
      cannot be excluded which should be considered especially for treatment monitoring
      and the estimation of BTV using [18F]FET PET.

PMID- 29845427
TI  - Setting Standards for Reporting and Quantification in Fluorescence-Guided
      Surgery.
AB  - PURPOSE: Intraoperative fluorescence imaging (FI) is a promising technique that
      could potentially guide oncologic surgeons toward more radical resections and
      thus improve clinical outcome. Despite the increase in the number of clinical
      trials, fluorescent agents and imaging systems for intraoperative FI, a
      standardized approach for imaging system performance assessment and post
      acquisition image analysis is currently unavailable. PROCEDURES: We conducted a
      systematic, controlled comparison between two commercially available imaging
      systems using a novel calibration device for FI systems and various fluorescent
      agents. In addition, we analyzed fluorescence images from previous studies to
      evaluate signal-to-background ratio (SBR) and determinants of SBR. RESULTS: Using
      the calibration device, imaging system performance could be quantified and
      compared, exposing relevant differences in sensitivity. Image analysis
      demonstrated a profound influence of background noise and the selection of the
      background on SBR. CONCLUSIONS: In this article, we suggest clear approaches for
      the quantification of imaging system performance assessment and post-acquisition
      image analysis, attempting to set new standards in the field of FI.

PMID- 29845428
TI  - Computed Tomography-Based Biomarker for Longitudinal Assessment of Disease Burden
      in Pulmonary Tuberculosis.
AB  - PURPOSE: Computed tomography (CT) images enable capturing specific manifestations
      of tuberculosis (TB) that are undetectable using common diagnostic tests, which
      suffer from limited specificity. In this study, we aimed to automatically
      quantify the burden of Mycobacterium tuberculosis (Mtb) using biomarkers
      extracted from x-ray CT images. PROCEDURES: Nine macaques were aerosol-infected
      with Mtb and treated with various antibiotic cocktails. Chest CT scans were
      acquired in all animals at specific times independently of disease progression.
      First, a fully automatic segmentation of the healthy lungs from the acquired
      chest CT volumes was performed and air-like structures were extracted. Next,
      unsegmented pulmonary regions corresponding to damaged parenchymal tissue and TB
      lesions were included. CT biomarkers were extracted by classification of the
      probability distribution of the intensity of the segmented images into three
      tissue types: (1) Healthy tissue, parenchyma free from infection; (2) soft
      diseased tissue, and (3) hard diseased tissue. The probability distribution of
      tissue intensities was assumed to follow a Gaussian mixture model. The thresholds
      identifying each region were automatically computed using an expectation
      maximization algorithm. RESULTS: The estimated longitudinal course of TB
      infection shows that subjects that have followed the same antibiotic treatment
      present a similar response (relative change in the diseased volume) with respect
      to baseline. More interestingly, the correlation between the diseased volume
      (soft tissue + hard tissue), which was manually delineated by an expert, and the
      automatically extracted volume with the proposed method was very strong (R2 ~
      0.8). CONCLUSIONS: We present a methodology that is suitable for automatic
      extraction of a radiological biomarker from CT images for TB disease burden. The
      method could be used to describe the longitudinal evolution of Mtb infection in a
      clinical trial devoted to the design of new drugs.

PMID- 29845429
TI  - Juvenile idiopathic arthritis in the biologic era: predictors of the disease
      progression and need for early introduction of biologic treatment.
AB  - To assess longitudinally the course and outcome of juvenile idiopathic arthritis
      (JIA) in patients diagnosed and followed-up exclusively in the biologic era;
      also, to define possible predictors of the disease progression and need for early
      implementation of biologicals. Prospective and retrospective, monocentric cohort
      study of 120 JIA patients, diagnosed between 2001 and 2010, and followed-up for
      >= 4 years (median 8.04). Disease activity, cumulative articular/extra-articular
      damage and quality of life were evaluated by the assessment tools Juvenile
      Arthritis Disease Activity Score (JADAS71), Juvenile Arthritis Damage Index
      (JADI) and Childhood Health Assessment Questionnaire (CHAQ), respectively.
      Moreover, potential predictors of the disease progression and their relation to
      biologic therapy were investigated. High JADAS71 score (> 9) at diagnosis was
      indicative of progression to polyarticular course and the need for early
      introduction of biologic treatment. Other independent predictors of progression
      to polyarthritis, were: involvement of upper limb, hip and ankle within 6 months
      following JIA diagnosis and percentage of cumulative time with active disease >
      35% within the first year. At the end of the study, both the median JADAS71 score
      and the Disability Index were significantly lower than the initial (p < 0.001)
      and remission off medication was achieved in 25% of the patients. Articular and
      extra-articular (only ocular) cumulative damage was demonstrated only in 5 and
      7.5% of patients, respectively. Physical functional ability was found
      normal/mildly restricted in 93.3% and moderately restricted in 6.7% of the
      patients. We believe that these findings, fit in with a picture of JIA course and
      outcome under current conditions of objective "disease status" evaluation and of
      tightly controlled follow-up. Predictors emerged from our study could contribute
      to the identification of patients who will need early implementation of biologic
      treatment.

PMID- 29845430
TI  - Lack of association between mean platelet volume and disease activity in systemic
      lupus erythematosus patients: a systematic review and meta-analysis.
AB  - Currently, many studies have focused on the possibility of using mean platelet
      volume (MPV) as a biomarker for disease activity in patients with systemic lupus
      erythematosus (SLE). To derive a more accurate estimation, a meta-analysis was
      conducted. Embase, PubMed, The Cochrane Library database and several Chinese
      databases (up to Nov 1 2017) were used to acquire published literatures on
      association of MPV levels with disease activity in SLE patients. Fixed-effects or
      random-effect model analysis was performed to calculate pooled standard mean
      difference (SMD) with 95% confidence interval (CI). Heterogeneity test was tested
      by the Q statistic and quantified using I2. A funnel plot and Egger's linear
      regression test were used to evaluate the potential publication bias. A total of
      618 articles were identified, nine studies with 376 active SLE patients and 270
      inactive SLE patients were finally included. No significant difference in MPV
      level was found between active SLE patients and inactive SLE patients (SMD = -
      0.05, 95% CI: - 0.83, 0.73). Subgroup analyses stratified by age or region also
      demonstrated consistent results. No significant publication bias was observed (P
      > 0.05). The sensitivity analysis showed no significant change when any one study
      was excluded. In summary, our meta-analysis does not support the use of MPV as an
      indicator for monitoring disease activity in SLE patients. Further longitudinal
      studies with larger sample size are warranted to unveil the possibility of using
      MPV as a biomarker of disease activity.

PMID- 29845431
TI  - Carpal tunnel syndrome treatment with palmitoylethanolamide: neurophysiology and
      ultrasound show small changes in the median nerve.

PMID- 29845432
TI  - MicroRNA values in children with rheumatic carditis: a preliminary study.
AB  - MicroRNAs (miRNAs) are fine regulators of gene expression which participate in
      the regulation of almost every phase of cell physiology, including development of
      immune cells and adjustment of immune response. In the studies with in vitro/in
      vivo model systems, specific miRNAs are revealed to have various roles in
      cardiovascular development and physiological functions. Furthermore, some studies
      have been done to understand the role of miRNAs about myocarditis, heart failure
      and coronary artery diseases. miRNAs crucial role in the pathogenesis of other
      rheumatic diseases have been investigated, however rheumatic carditis was not
      studied. The aim of this study is to assess values of miRNAs in children with
      rheumatic carditis and compare them with healthy children. This study included 36
      children with rheumatic carditis (mean aged 12.1 +/- 2.1 years) and age-gender
      matched 35 healthy controls (mean aged 11.1 +/- 2.3 years). Conventional
      echocardiography was performed to all subjects. Using real-time polymerase chain
      reaction, the expression of some miRNAs (hsamiR-16-5p, hsa-miR-221-3p, hsa-miR
      223-3p, hsa-miR-10a-5p, hsa-miR-24-3p, hsamiR-92a-3p, hsa-iR-320a, hsa-miR-21-5p,
      hsa-miR-155-5p, hsa-miR-132-3p, hsamiR-146a-5p, hsa-miR-499a-5p, hsa-miR-1, hsa
      miR-125, hsa-miR-196a-5p, hsa-miR-130b-3p, hsa-miR-133b, hsa-miR150-5p,hsa-miR
      204-5p, hsa-miR-203a) were analyzed. hsa-miR-16-5p(-1.46 fold, p < 0.01), hsa-miR
      223-3p(-1.46 fold, p < 0.01), and hsa-miR-92a-3p(-1.27 fold, p < 0.05)
      expressions in the patients were lower than those of controls, whereas other
      examined miRNAs did not differently express between the groups. Results of the
      study demonstrated that significant downregulation of hsa-miR-16-5p, hsa-miR-223
      3p and hsa-miR-92a-3p in children with rheumatic carditis. Since, this is the
      first study in children with rheumatic carditis, further studies are needed for
      lightening whether these miRNAs might be helpful as biomarkers.

PMID- 29845433
TI  - Some task demands induce collapsing bounds: Evidence from a behavioral analysis.
AB  - Traditional models of choice-response time assume that sensory evidence
      accumulates for choice alternatives until a threshold amount of evidence has been
      obtained. Although some researchers have characterized the threshold as varying
      randomly from trial to trial, these investigations have all assumed that the
      threshold remains fixed across time within a trial. Despite decades of successful
      applications of these models to a variety of experimental manipulations, the time
      invariance assumption has recently been called into question, and a time-variant
      alternative implementing collapsing decision thresholds has been proposed
      instead. Here, we investigated the fidelity of the collapsing threshold
      assumption by assessing relative model fit to data from a highly constrained
      experimental design that coupled a within-subject mixture of two classic response
      time paradigms-interrogation and free response-within a random dot motion (RDM)
      task. Overall, we identified strong evidence in favor of collapsing decision
      thresholds, suggesting that subjects may adopt a dynamic decision policy due to
      task characteristics, specifically to account for the mixture of response time
      paradigms and motion strengths across trials in the mixed response signal task.
      We conclude that time-variant mechanisms may serve as a viable explanation for
      the strategy used by human subjects in our task.

PMID- 29845434
TI  - Optimized partial-coverage functional analysis pipeline (OPFAP): a semi-automated
      pipeline for skull stripping and co-registration of partial-coverage, ultra-high
      field functional images.
AB  - OBJECTIVE: Ultra-high-field functional MRI (UHF-fMRI) allows for higher
      spatiotemporal resolution imaging. However, higher-resolution imaging entails
      coverage limitations. Processing partial-coverage images using standard pipelines
      leads to sub-optimal results. We aimed to develop a simple, semi-automated
      pipeline for processing partial-coverage UHF-fMRI data using widely used image
      processing algorithms. MATERIALS AND METHODS: We developed automated pipelines
      for optimized skull stripping and co-registration of partial-coverage UHF
      functional images, using built-in functions of the Centre for Functional Magnetic
      Resonance Imaging of the Brain's (FMRIB's) Software library (FSL) and advanced
      normalization tools. We incorporated the pipelines into the FSL's functional
      analysis pipeline and provide a semi-automated optimized partial-coverage
      functional analysis pipeline (OPFAP). RESULTS: Compared to the standard pipeline,
      the OPFAP yielded images with 15 and 30% greater volume of non-zero voxels after
      skull stripping the functional and anatomical images, respectively (all p =
      0.0004), which reflected the conservation of cortical voxels lost when the
      standard pipeline was used. The OPFAP yielded the greatest Dice and Jaccard
      coefficients (87 and 80%, respectively; all p < 0.0001) between the co-registered
      participant gyri maps and the template gyri maps, demonstrating the goodness of
      the co-registration results. Furthermore, the greatest volume of group-level
      activation in the most number of functionally relevant regions was observed when
      the OPFAP was used. Importantly, group-level activations were not observed when
      using the standard pipeline. CONCLUSION: These results suggest that the OPFAP
      should be used for processing partial-coverage UHF-fMRI data for detecting high
      resolution macroscopic blood oxygenation level-dependent activations.

PMID- 29845435
TI  - Molecular insight on the non-covalent interactions between carbapenems and L,D
      transpeptidase 2 from Mycobacterium tuberculosis: ONIOM study.
AB  - Tuberculosis remains a dreadful disease that has claimed many human lives
      worldwide and elimination of the causative agent Mycobacterium tuberculosis also
      remains elusive. Multidrug-resistant TB is rapidly increasing worldwide;
      therefore, there is an urgent need for improving the current antibiotics and
      novel drug targets to successfully curb the TB burden. L,D-Transpeptidase 2 is an
      essential protein in Mtb that is responsible for virulence and growth during the
      chronic stage of the disease. Both D,D- and L,D-transpeptidases are inhibited
      concurrently to eradicate the bacterium. It was recently discovered that classic
      penicillins only inhibit D,D-transpeptidases, while L,D-transpeptidases are
      blocked by carbapenems. This has contributed to drug resistance and persistence
      of tuberculosis. Herein, a hybrid two-layered ONIOM (B3LYP/6-31G+(d): AMBER)
      model was used to extensively investigate the binding interactions of LdtMt2
      complexed with four carbapenems (biapenem, imipenem, meropenem, and tebipenem) to
      ascertain molecular insight of the drug-enzyme complexation event. In the studied
      complexes, the carbapenems together with catalytic triad active site residues of
      LdtMt2 (His187, Ser188 and Cys205) were treated at with QM [B3LYP/6-31+G(d)],
      while the remaining part of the complexes were treated at MM level (AMBER force
      field). The resulting Gibbs free energy (DeltaG), enthalpy (DeltaH) and entropy
      (DeltaS) for all complexes showed that the carbapenems exhibit reasonable binding
      interactions towards LdtMt2. Increasing the number of amino acid residues that
      form hydrogen bond interactions in the QM layer showed significant impact in
      binding interaction energy differences and the stabilities of the carbapenems
      inside the active pocket of LdtMt2. The theoretical binding free energies
      obtained in this study reflect the same trend of the experimental  observations.
      The electrostatic, hydrogen bonding and Van der Waals interactions between the
      carbapenems and LdtMt2 were also assessed. To further examine the nature of
      intermolecular interactions for carbapenem-LdtMt2 complexes, AIM and NBO analysis
      were performed for the QM region (carbapenems and the active residues of LdtMt2)
      of the complexes. These analyses revealed that the hydrogen bond interactions and
      charge transfer from the bonding to anti-bonding orbitals between catalytic
      residues of the enzyme and selected ligands enhances the binding and stability of
      carbapenem-LdtMt2 complexes. The two-layered ONIOM (B3LYP/6-31+G(d): Amber) model
      was used to evaluate the efficacy of FDA approved carbapenems antibiotics towards
      LdtMt2.

PMID- 29845436
TI  - Macula halo syndrome.
AB  - INTRODUCTION: Niemann-Pick disease (NPD) is a hereditary lysosomal storage
      disorder in which mutations in the sphingomyelin phosphodiesterase gene leads to
      partial or complete deficiency of the sphingomyelinase enzyme. Niemann-Pick Type
      B is the intermediate form associated with hepatosplenomegaly, foam cells in the
      bone marrow, hyperlipidemia and diffuse pulmonary infiltrates, which is generally
      diagnosed in late adolescence. Central nervous system is not affected, and some
      cases may display macular halo. CASE: A 45-year-old female seen in ophthalmology
      clinic for the examination of the eyes. Extraocular motility was normal
      bilaterally, and the visual acuity was 20/25 for both eyes. Biomicroscopic
      examination revealed faint corneal haze bilaterally, Circular pale granular
      depositions were detected in the parafoveal retina on both eyes. Optical
      coherence tomography (OCT) revealed thin hyperreflective band corresponding to
      depositions located in the parafoveolar inner retina. Microperimeter showed
      slight depression in retinal sensitivity, which was more pronounced particularly
      on perifovea rather than parafovea. CONCLUSIONS: Challenge to identify the NPD
      subtype of this case is associated with phenotypic characteristics on a wider
      spectrum that overlap the currently described subtypes.

PMID- 29845437
TI  - Gestalt grouping cues can improve filtering performance in visual working memory.
AB  - As part of filtering irrelevant information from entering visual working memory
      (VWM) and selecting only the relevant information for further processing the
      system should first tag the pieces of information as relevant or irrelevant. We
      manipulated difficulty of tagging items as relevant or irrelevant by applying
      perceptual grouping cues to investigate if it can improve filtering performance
      in VWM. Participants performed a change-detection task with three targets, six
      targets, or three targets and three distractors (filtering condition) in the
      memory display, and were asked to remember the colors (Experiments 1-2) or the
      orientations (Experiments 3-5) of the targets and ignore the distractors. In the
      filtering conditions, either the targets (Experiments 1, 3, and 4) or the
      distractors (Experiments 2 and 5) formed an illusory object (a Kanizsa triangle),
      appeared in a triangle-like configuration (grouping by proximity), or appeared at
      random positions (non-grouping). Grouping the targets improved filtering
      performance relative to non-grouping. Moreover, the illusory object cue further
      improved filtering performance beyond a proximity cue, but only when the cue was
      compatible with the task. When the distractors were grouped, the proximity cue
      improved filtering performance, and the illusory object cue, despite being a
      potent grouping cue, failed to improve filtering performance when it was
      compatible with the task. We suggest that the grouping cues advanced tagging of
      the grouped items. Yet, when the grouping cue strongly enhanced processing of the
      distractors, the tagging failed, such that the preliminary process of estimating
      incoming items led to full processing of the grouped items.

PMID- 29845438
TI  - Levodopa-responsive breathing discomfort in Parkinson's disease patients.
AB  - In Parkinson's disease (PD), respiratory disturbances have been reported and the
      effect of levodopa on respiratory function remains controversial. The objective
      of this study was to evaluate pulmonary function utilizing spirometric and
      subjective evaluations in mild to moderated PD. Thirty-four consecutive sporadic
      PD patients (Hoehn and Yahr scale: 1-3) were prospectively evaluated using
      clinimetric scales, spirometry and modified Borg scale, all in off- and on
      conditions. To check the respiratory function, a follow-up was performed at 4
      years in a subgroup of these patients. Spirometric results were normal for all
      patients in both the on- and off-conditions at baseline. After levodopa
      administration, in addition to a significant improvement in subjective state of
      breathing discomfort, the mean forced expiratory volume in 1 s (FEV1), vital
      capacity (VC), forced vital capacity (FVC) values and their mean percentages
      predicted values (FEV1%, VC%, FVC%) were significantly increased (p < 0.05).
      Moreover, residual volume, total lung capacity, and the FEV1/FVC ratio were not
      significantly different for the ON and OFF conditions. At 4-year follow-up no
      resulting variations in the baseline values for FEV1%, FVC% or VC% were revealed.
      The results from this prospective study suggest that PD patients report
      frequently pulmonary discomfort. Levodopa improves respiratory symptoms.
      Pulmonary restrictive and obstructive dysfunctions, when not present at baseline,
      might not be present at 4-year follow-up.

PMID- 29845439
TI  - The Application of Induced Pluripotent Stem Cells in Cardiac Disease Modeling and
      Drug Testing.
AB  - In recent decades, cardiovascular diseases have become the greatest health threat
      to human beings, and thus it is particularly important to explore the subtle
      underlying pathogenesis of cardiovascular diseases. Although many molecular
      pathways have been explored to be essential in the development of cardiovascular
      diseases, their clinical significances are still uncertain. With the emergence of
      induced pluripotent stem cells (iPSCs), a unique platform for cardiovascular
      diseases has been established to model cardiovascular diseases on specific
      genetic background in vitro. This review summarizes current progresses of iPSCs
      in cardiovascular disease modeling and drug testing. This review highlighted iPSC
      based cardiovascular disease modeling and drug testing. The technical advances in
      iPSC-based researches and various clinically relevant applications are discussed.
      With further intensive research, iPSC technology will shape the future of
      clinical translational research in cardiovascular diseases.

PMID- 29845440
TI  - Speckle-Tracking Echocardiographic Strain Analysis Reliably Estimates Degree of
      Acute LV Unloading During Mechanical LV Support by Impella.
AB  - Non-invasive means of evaluating appropriate cardiac unloading remain to be
      established. We hypothesized that myocardial deformation assessed by
      echocardiographic speckle-tracking strain analysis can reliably estimate the
      degree of left ventricular (LV) unloading under mechanical circulatory support. A
      total of 24 Yorkshire pigs underwent Impella-mediated acute LV unloading 1-2
      weeks after myocardial infarction (MI). Echocardiographic and invasive pressure
      volume measurements were used to evaluate the degree of LV unloading. Pressure
      volume analysis before and after LV unloading exhibited a significant decrease in
      stroke work (3399 +/- 1440 to 1244 +/- 659 mmHg ml, p < 0.001), suggesting
      reduced external cardiac work. Both longitudinal strain (- 14.6 +/- 4.1% to -
      10.6 +/- 2.3%, p < 0.001) and circumferential strain (- 18.7 +/- 6.1% to - 9.3 +/
      3.5%, p < 0.001) decreased after LV unloading, and there were linear
      relationships between stroke work and echocardiographic longitudinal (r = - 0.61,
      p < 0.001) as well as circumferential strains (r = - 0.75, p < 0.001).
      Echocardiographic LV strain analysis offers a non-invasive assessment of LV
      unloading in subacute MI.

PMID- 29845441
TI  - Fear of Negative Evaluation and Weight/Shape Concerns among Adolescents: The
      Moderating Effects of Gender and Weight Status.
AB  - Fear of negative evaluation has been linked with weight/shape concerns among
      adults, however, similar research among adolescents is lacking. We investigated
      the relationship between fear of negative evaluation and weight/shape concerns,
      including the moderating roles of gender and body mass index (BMI) in
      adolescents. Participant were 4045 Australian adolescents (53.7% girls) aged 11
      19 years (Mage = 14 years 11 months), who completed a self-report questionnaire
      about weight/shape concerns, fear of negative evaluation, and weight and height.
      Results showed a positive association between fear of negative evaluation and
      weight/shape concerns, with the association being stronger among girls.
      Furthermore, the association between fear of negative evaluation and weight/shape
      concerns was stronger among adolescents with higher BMIs, especially so for boys.
      These results highlight the role of fear of negative evaluation in weight/shape
      concerns and suggest potential avenues for prevention programs.

PMID- 29845442
TI  - Defending Victims of Bullying in Early Adolescence: A Multilevel Analysis.
AB  - Adolescents' defending behaviors in school bullying situations is likely
      determined by individual characteristics, social status variables, and
      classroom/school contextual factors operating simultaneously in the peer ecology.
      However, there is little research on defending behavior that utilizes this
      multilevel approach. This study investigated how students' willingness to defend
      victims of bullying was affected by feelings of empathy, perceived popularity,
      and classroom-level perceived prosocial norms. Participants were 1373 adolescents
      (40% girls, Mage: 14 yrs) from 54 classrooms in six middle schools in South
      Korea. These youth reported on their feelings of empathy and how prosocial they
      perceived their classmates to be. Peer-ratings and peer nominations were used to
      estimate defending behaviors and which students were perceived as popular.
      Multilevel analyses showed that participants were more likely to defend victims
      when they had greater empathy and perceived popularity and when classroom-level
      prosocial norms were higher. The findings have implications for interventions to
      reduce school bullying and for studying defending behavior in multiple cultural
      contexts.

PMID- 29845443
TI  - Identification of Nonconsensual Sexual Experiences and the Sexual Self-Schemas of
      Women: Implications for Sexual Functioning.
AB  - Many individuals who experience nonconsensual sexual experiences (NSEs) do not
      identify their experiences with common sexual violence labels (e.g., sexual
      assault, rape, or abuse), and cognitive mechanisms of identification have yet to
      be examined. Identification may involve the integration of the experience into
      sexual self-schemas, which would have implications for sexual well-being. Women
      were recruited through Amazon's Mechanical Turk (N = 818) to take part in an
      anonymous online study of sexual experiences. The current study assessed the
      relationship between textually derived sexual self-schemas and sexual function
      (measured by the Female Sexual Function Index) in women (M = 35.37 years, SD =
      11.27) with NSEs who both did (identifiers, n = 305) and did not (non
      identifiers, n = 176) identify with common sexual violence labels, in comparison
      with those with no NSEs (n = 337). Text analyses revealed nine sexual self-schema
      themes in participants' essays: Virginity, Openness, Erotophilia, NSEs, Romantic,
      Sexual Activity, Warmth, Relationships, and Reflection. Analyses demonstrated
      that identifiers reported significantly poorer sexual functioning and less use of
      both the Warmth and Openness themes than those with no NSEs. Identifiers also
      invoked the NSE theme more frequently than both those with no NSE histories and
      non-identifiers. While greater prominence of the Warmth theme was predictive of
      greater sexual functioning for both non-identifiers and those with no NSEs, this
      was not true for identifiers. Instead, the NSE theme was significantly predictive
      of lower sexual functioning in identifiers. The results suggest that NSE
      identification may result in greater internalization of the NSE into one's sexual
      self-schema and, in turn, predict decrements in sexual functioning. The results
      are discussed in relation to identification interpretation and clinical
      intervention.

PMID- 29845444
TI  - Average Associations Between Sexual Desire, Testosterone, and Stress in Women and
      Men Over Time.
AB  - Sexual desire and testosterone are widely assumed to be directly and positively
      linked to each other despite the lack of supporting empirical evidence. The
      literature that does exist is mixed, which may result from a conflation of
      solitary and dyadic desire, and the exclusion of contextual variables, like
      stress, known to be relevant. Here, we use the Steroid/Peptide Theory of Social
      Bonds as a framework for examining how testosterone, solitary and partnered
      desire, and stress are linked over time. To do so, we collected saliva samples
      (for testosterone and cortisol) and measured desire as well as other variables
      via questionnaires over nine monthly sessions in 78 women and 79 men. Linear
      mixed models showed that testosterone negatively predicted partnered desire in
      women but not men. Stress moderated associations between testosterone and
      solitary desire in both women and men, but differently: At lower levels of
      stress, higher average testosterone corresponded to higher average solitary
      desire for men, but lower solitary desire on average for women. Similarly, for
      partnered desire, higher perceived stress predicted lower desire for women, but
      higher desire for men. We conclude by discussing the ways that these results both
      counter presumptions about testosterone and desire but fit with the existing
      literature and theory, and highlight the empirical importance of stress and
      gender norms.

PMID- 29845445
TI  - Multidimensional Patterns of Sexual Risk Behavior and Psychiatric Disorders in
      Men with Substance Use Disorders.
AB  - Previous evidence links substance use disorders (SUD) to STI/HIV risk and
      suggests that comorbid psychiatric disorders increase the probability to engage
      in sexual risk behaviors. This study had two aims: (1) to identify subgroups
      based on sexual risk behavior using a person-centered approach in a sample of
      substance users and (2) to measure the association of psychiatric and SUD with
      subgroup membership. We assessed 402 male adults with SUD, reporting sexual
      intercourse in the previous 12 months using the HIV-Risk Behavior Scale and the
      Mini International Neuropsychiatric Interview. Latent class analysis was
      performed to determine multidimensional patterns of sexual risk behaviors and
      multinomial logistic regression was utilized to associate classes with disorders.
      The three-class model showed the best fit, and the classes were labeled:
      Relationship-Based (31.34% of the sample), Condom-Based (39.55%), and Multiple
      Risks (29.10%). Controlling for age and marital status, major depressive
      disorders, antisocial personality disorder, and any psychiatric disorder were
      associated with the Multiple Risks class. Results stress the importance of
      developing a personalized assessment and counseling for sexual risk behaviors in
      individuals with SUD, particularly when they endorse criteria for comorbid
      psychiatric disorders. Future studies should focus on evaluating differential
      response to preventive interventions.

PMID- 29845446
TI  - Protein levels of ADAM10, BACE1, and PSEN1 in platelets and leukocytes of
      Alzheimer's disease patients.
AB  - The clinical diagnosis of Alzheimer's disease (AD) is a probabilistic formulation
      that may lack accuracy particularly at early stages of the dementing process.
      Abnormalities in amyloid-beta precursor protein (APP) metabolism and in the level
      of APP secretases have been demonstrated in platelets, and to a lesser extent in
      leukocytes, of AD patients, with conflicting results. The aim of the present
      study was to compare the protein level of the APP secretases A-disintegrin and
      metalloprotease 10 (ADAM10), Beta-site APP-cleaving enzyme 1 (BACE1), and
      presenilin-1 (PSEN1) in platelets and leukocytes from 20 non-medicated older
      adults with AD and 20 healthy elders, and to determine the potential use of these
      biomarkers to discriminate cases of AD from controls. The protein levels of all
      APP secretases were significantly higher in platelets compared to leukocytes. We
      found statistically a significant decrease in ADAM10 (52.5%, p < 0.0001) and
      PSEN1 (32%, p = 0.02) in platelets from AD patients compared to controls, but not
      in leukocytes. Combining all three secretases to generate receiver-operating
      characteristic (ROC) curves, we found a good discriminatory effect (AD vs.
      controls) when using platelets (the area under the curve-AUC-0.90, sensitivity
      88.9%, specificity 66.7%, p = 0.003), but not in leukocytes (AUC 0.65,
      sensitivity 77.8%, specificity 50.0%, p = 0.2). Our findings indicate that
      platelets represent a better biological matrix than leukocytes to address the
      peripheral level of APP secretases. In addition, combining the protein level of
      ADAM10, BACE1, and PSEN1 in platelets, yielded a good accuracy to discriminate AD
      from controls.

PMID- 29845447
TI  - Longitudinal association between motor and obsessive compulsive symptoms in
      patients with psychosis and their unaffected siblings.
AB  - Little is known about the co-prevalence of obsessive compulsive symptoms (OCS)
      and motor symptoms in patients with psychotic disorders. Cross-sectional
      associations between OCS and motor symptoms were assessed at baseline and at 3
      years follow-up in patients (n = 726) with psychotic disorders and in their
      unaffected siblings (n = 761) from the Dutch Genetic Risk and Outcome of
      Psychosis (GROUP) study. Furthermore, longitudinal associations between changes
      in OCS and motor symptoms were evaluated. At baseline, OCS was not associated
      with any motor symptom (akathisia, dyskinesia, parkinsonism or dystonia) in
      patients. At follow-up, patients with OCS reported significantly more akathisia.
      Dividing the patients into four groups-no OCS, OCS remission with OCS only at
      baseline, OCS de novo with OCS only at follow-up and a persistent OCS group
      revealed that the OCS de novo group already reported more akathisia at baseline
      compared to the no-OCS group. At follow-up, both the OCS de novo and the
      persistent OCS group reported more akathisia. These results remained significant
      after correcting for relevant confounders clozapine, GAF score, PANSS-negative
      score and IQ. Motor symptoms at baseline were significantly associated with OCS
      at follow-up, but not the other way around. In siblings, OCS at baseline was
      associated with akathisia, but this association was lost at follow-up. Results
      suggest that motor symptoms might precede co-occurring OCS in patients with
      psychotic disorders. However, no inference can be made about causality, and
      further prospective research is needed to investigate this assumption.

PMID- 29845448
TI  - Ghrelin-containing neurons in the olfactory bulb send collateralized projections
      into medial amygdaloid and arcuate hypothalamic nuclei: neuroanatomical study.
AB  - Ghrelin, a gastrointestinal hormone, is a modulator of the sense of smell. The
      main source of ghrelin in the central nervous system has been mainly observed in
      specific populations of hypothalamic neurons. An increasing number of studies
      have reported ghrelin synthesis and its effect on neurons outside the
      hypothalamus. Ghrelin and its receptors are expressed in the olfactory bulbs and
      in other centres of the brain, such as the amygdala, for processing olfactory
      signals, pyramidal neurons of the cerebral cortex and the dorsal vagal complex of
      the medulla oblongata. It is known that ghrelin is involved in cognitive
      mechanisms and eating behaviours, in fact, its expression increases in
      anticipation of food intake. In order to identify the existence of centrifugal
      direct afferents from the main olfactory bulb to the medial amygdala and the
      hypothalamus arcuate nucleus, in this work we used two retrograde tracers, Dil
      and Fluoro Gold, and immunohistochemical procedure to visualize positive ghrelin
      neurons. Our paper provides neuroanatomic support for the ghrelin modulation of
      smell. Our results show that ghrelin neuron projections from mitral cells of
      bulbs can transmit olfactory information via branching connections to the
      amygdala and the hypothalamus. This pathway could play an important role in
      regulating feeding behaviour in response to odours.

PMID- 29845450
TI  - Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse
      Events Assessed in the Halothane-Anesthetized Dogs.
AB  - Lithium is one of the classical drugs that have been widely used for treating
      bipolar disorder. However, several cardiac side effects including sick sinus
      syndrome, bundle branch block, ventricular tachycardia/fibrillation, non-specific
      T-wave abnormalities in addition to Brugada-type electrocardiographic changes
      have been noticed in patients who were given antidepressant, anticonvulsant,
      and/or antipsychotic drugs besides lithium. In this study, we assessed
      cardiohemodynamic and electrophysiological effects of lithium carbonate by itself
      to begin to analyze onset mechanisms of its cardiovascular side effects. Lithium
      carbonate in intravenous doses of 0.1, 1, and 10 mg/kg over 10 min was
      cumulatively administered with an interval of 20 min to the halothane
      anesthetized beagle dogs (n = 4), which provided peak plasma Li+ concentrations
      of 0.02, 0.18, and 1.79 mEq/L, respectively, reflecting sub-therapeutic to toxic
      concentrations. The low and middle doses prolonged the ventricular effective
      refractory period at 30 min and for 5-30 min, respectively. The high dose
      decreased the heart rate for 45-60 min, delayed the intraventricular conduction
      for 15-20 min and the ventricular repolarization at 45 min, and prolonged the
      effective refractory period for 5-60 min. No significant change was detected in
      the other cardiovascular variables. Thus, lithium alone may have a wide safety
      margin against hemodynamic adverse events; however, it would directly and/or
      indirectly inhibit Na+ and K+ channels, which may synergistically increase the
      ventricular refractoriness from the sub-therapeutic concentration and decrease
      the heart rate at the supra-therapeutic one. These findings may partly explain
      its clinically observed various types of arrhythmias as well as
      electrocardiographic changes.

PMID- 29845449
TI  - The time course of brief and prolonged topical 8% capsaicin-induced
      desensitization in healthy volunteers evaluated by quantitative sensory testing
      and vasomotor imaging.
AB  - Topically applied high-concentration capsaicin induces reversible dermo-epidermal
      denervation and depletion of capsaicin-sensitive nociceptors. This causes
      desensitization of distinct sensory modalities and is used to treat peripheral
      neuropathic pain and itch. For high-concentration capsaicin, the selectivity of
      loss of function and functional recovery rates of various afferent fibers
      subpopulations are unknown. This study used comprehensive quantitative sensory
      testing and vasomotor imaging to assess effectiveness, duration and sensory
      selectivity of high-concentration 8% capsaicin-ablation. Skin areas in 14 healthy
      volunteers were randomized to treatment with 8% capsaicin/vehicle patches for 1
      and 24 h and underwent comprehensive sensory and vasomotor testing at 1, 7 and 21
      days postpatch removal. Tests consisted of thermal detection and pain thresholds,
      tactile and vibration detection thresholds, mechanical pain threshold and
      mechanical pain sensitivity as well as micro-vascular and itch reactivity to
      histamine provocations. The 24 h capsaicin drastically inhibited warmth detection
      (P < 0.001), heat pain (P < 0.001) as well as histamine-induced itch (P < 0.05)
      and neurogenic flare (P < 0.001), but had no impact on tactile sensitivity, cold
      detection and cold pain. A marginal decrease in mechanical pain sensitivity was
      observed (P < 0.05). Capsaicin for 1 h had limited and transient sensory effects
      only affecting warmth and heat sensations. Time-dependent functional recovery was
      almost complete 21 days after the 24 h capsaicin exposure, while recovery of
      neurogenic inflammatory responsiveness remained partial. The psychophysically
      assessed sensory deficiencies induced by the used 8% capsaicin-ablation
      correspond well with a predominant effect on TRPV1+-cutaneous fibers. The method
      is easy to apply, well tolerated, and utilizable for studies on, e.g.,
      interactions between skin barrier, inflammation and capsaicin-sensitive
      afferents.

PMID- 29845451
TI  - Resveratrol promotes the embryonic development of vitrified mouse oocytes after
      in vitro fertilization.
AB  - Vitrification of oocytes is closely associated with the lower embryonic
      developmental potential, which involves the cryopreservation injury occurred
      during vitrification. It indicates that vitrification may need to be further
      optimized. Therefore, we studied the effects of resveratrol, an antioxidant, on
      the developmental potential of vitrified mouse oocytes after in vitro
      fertilization. After adding a series of concentrations of resveratrol (0, 1, 10,
      25, and 50 MUM) into vitrification, warming, and post-warming mediums, we found
      that 25 and 50 MUM resveratrol increased the blastocyst formation rate of
      vitrified oocytes. We further showed that 25 MUM resveratrol increased the mean
      cell numbers of blastocyst from vitrified oocytes. 25 MUM resveratrol reduced
      oxidative stress of vitrified oocytes through decreasing the levels of reactive
      oxygen species (ROS) and increasing the levels of glutathione (GSH), and 25 MUM
      resveratrol alleviated the abnormal mitochondrial distribution pattern of oocytes
      after vitrification. In conclusion, our study implied that resveratrol could
      diminish the cryopreservation injuries during the vitrification of mouse oocytes
      and further confirmed that resveratrol may be an effective antioxidant to
      optimize vitrification.

PMID- 29845452
TI  - Establishment and characterization of patient-derived xenograft and its cell line
      of primary leiomyosarcoma of bone.
AB  - Primary leiomyosarcoma (LMS) of bone is a rare and aggressive mesenchymal
      malignancy that differentiates toward smooth muscle. Complete resection is the
      only curable treatment, and novel therapeutic approaches for primary LMS of bone
      have long been desired. Patient-derived xenografts (PDXs) and cell lines are
      invaluable tools for preclinical studies. Here, we established PDXs from a
      patient with primary LMS of bone and a cell line from an established PDX. Bone
      primary LMS tissue was subcutaneously implanted into highly immune-deficient
      mice. After two passages, a piece of the tumor was subjected to tissue culturing,
      and a morphological evaluation and proteomic analysis were performed on the PDX
      and the established cell line. Moreover, the responses of the established cell
      line to anti-cancer drugs were examined. Microscopic observations revealed that
      the PDX tumors retained their original histology. The cell line was established
      from the third-generation PDX and named NCC-LMS1-X3-C1. The cells were maintained
      for over 18 mo and 40 passages. The cells exhibited a spindle shape and
      aggressive growth. Mass spectrometric protein identification revealed that the
      original tumor tissue, PDX tumor tissue, and NCC-LMS1-X3-C1 cells had similar but
      distinct protein expression profiles. We previously established the cell line,
      NCC-LMS1-C1, from the tumor tissue of same patient. We found that the response to
      drug treatments was different between NCC-LMS1-X3-C1 and NCC-LMS1-C1, suggesting
      the heterogeneous traits of tumor cells in the identical tumor tissue. This set
      of PDXs and stable cell line will be a useful resource for bone LMS research.

PMID- 29845453
TI  - Evolutionary image simplification for lung nodule classification with
      convolutional neural networks.
AB  - PURPOSE: Understanding decisions of deep learning techniques is important.
      Especially in the medical field, the reasons for a decision in a classification
      task are as crucial as the pure classification results. In this article, we
      propose a new approach to compute relevant parts of a medical image. Knowing the
      relevant parts makes it easier to understand decisions. METHODS: In our approach,
      a convolutional neural network is employed to learn structures of images of lung
      nodules. Then, an evolutionary algorithm is applied to compute a simplified
      version of an unknown image based on the learned structures by the convolutional
      neural network. In the simplified version, irrelevant parts are removed from the
      original image. RESULTS: In the results, we show simplified images which allow
      the observer to focus on the relevant parts. In these images, more than 50% of
      the pixels are simplified. The simplified pixels do not change the meaning of the
      images based on the learned structures by the convolutional neural network. An
      experimental analysis shows the potential of the approach. Besides the examples
      of simplified images, we analyze the run time development. CONCLUSIONS:
      Simplified images make it easier to focus on relevant parts and to find reasons
      for a decision. The combination of an evolutionary algorithm employing a learned
      convolutional neural network is well suited for the simplification task. From a
      research perspective, it is interesting which areas of the images are simplified
      and which parts are taken as relevant.